S65
S65, S.65, or S-65 may refer to:
 S95, a postcode district in the S postcode area
 BMW S65, a 2007 naturally aspirated DOHC 32-valve V8 automobile engine
 Greek submarine Triaina (S-65), a Balao-class submarine in commission in the Hellenic Navy from 1965 to 1980
 Savoia-Marchetti S.65, an Italian racing seaplane of 1929
 Siemens S65, a mobile phone
 Sikorsky S-65, a family of heavy-lift transport helicopters
 INS Sindhushastra (S65), an Indian Navy Sindhughosh class submarine commissioned in 2000
 Mercedes-Benz S65 AMG, a sedan built by Mercedes-Benz AMG