Discounts are available for Anthraquinone-C2-dT!
Anthraquinone-modified oligonucleotides have proven to be versatile tools in stabilization of duplex DNA by intercalation (1),electrochemical detection of single-base mismatches (SNPs)(2),and as photoexcitable probes for the study of DNA hole transport(3). Charge-transfer phenomena in DNA either through oxidativeor reductive pathways have received considerable attention in recent years due to their importance in biological environments such protein-DNA complexes, DNA damage, mutations and cancer (4). Anthraquinones can be incorporated into oligonucleotides by using Anthraquinone-C2-dT during oligo synthesis.The anthraquinone moiety is useful for applications such as intercalation, duplex and triplex stabilization, photochemical immobilization, quenching of fluorescence, electrochemical detection, and charge transport through nucleic acids.
Anthraquinone-C2-dT CEP features an electronically insulating tether that places the anthraquinone at a significant distance from the oligonucleotide. Dialkoxy derivatives of anthraquinone (AQ), dicyano-anthraquinone (DCAQ) and tetracyanoanthraquinone (TCAQ). displayed quasireversible, two sequential one-electron transfer redox reactions. DFT calculations of DCAQ and TCAQ demonstrate structural changes upon reduction, which is supported by spectroelectrochemical experiments.
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Review: H.-A. Wagenknecht,Nat. Prod. Rep., 2006,23, 973-1006 and references therein. Charge-transfer in DNA: From mechanism to Application, ed. H.-A.Wagenknecht, Wiley-VCH, Weinheim, 2005.5 E. Mayer-Enthart and H.-A. Wagenknecht,Ange.
Murschell, A.E., Kan, W.H., Thangaduraia, V. and Sutherland, T.C. Phys. Chem. Chem. Phys., 2012,14, 4626-4634.
