3 21 Pigs will be divided into 3 groups, under 3 different BAL system conditions: Clinical-grade (GMP) BAL Systems will be utilized; - Standard ICU/ Clinical treatment (n=7); - BAL System treatment - WITHOUT HepaRG cells (n=7) - BAL System treatment - WITH HepaRG cells (n=7); *A preliminary phase of 5-7 animals to establish the ALF model will start as soon as feasible.