The spirulina group had significantly higher mRNA expression of GRAβ3 gene than the tinnitus group in the cochlea (1.07 ± 0.22, post-hoc Bonferroni analysis, p=0.003) (Figure 2), in the brainstem and IC (0.96 ± 0.08, posthoc Bonferroni analysis, p<0.001) (Figure 3), in the temporal lobes (0.77±0.08, post-hoc Bonferroni analysis, p=0.050) (Figure 5), in the frontal lobes (1.15 ± 0.10, post-hoc Bonferroni analysis, p<0.001) (Figure 6), and in the hippocampus and para-hippocampus (1.12 ± 0.14, post-hoc Bonferroni analysis, p=0.001) (Figure 4).