harmful substances can cause disease in human
toxic_substance is biochemically_harmful_substance. substance_abuse is not human_activity. psychoactive_drug is not toxic_substance. biochemically_harmful_substance is dangerous_thing. psychoactive_drug is toxic_substance. toxic_substance is not human_pathogen. human_papillomavirus is disease. substance_abuse is human_activity. human_papillomavirus is not disease. toxic_substance is human_pathogen.