While Dr. Charlie Eppes (David Krumholtz), a CalSci math professor/FBI math consultant, rehearses a lecture on entropy and his brother, FBI Special Agent Don Eppes (Rob Morrow), is at temple, federal prisoner Buck Winters (David Gallagher) escapes from prison along with two other prisoners.
David, Colby, Nikki, and Liz find one of the escaped prisoners dead at a hotel.