Pomponia married Aulus Plautius (d. by 65 AD), the senator and general who led the Roman conquest of Britain in 43 AD, for which he later received a military ovation, and who governed Roman Britain until 47 AD.
In 43 AD Pomponia's relative Julia, daughter of her uncle Julius Caesar Drusus, was executed on the orders of her maternal uncle, the emperor Claudius at the instigation of the empress Valeria Messalina.