Historically, the Mattaponi River has been known by a variety of names and alternate spellings, including Mat-ta-pa-ment, Matapanient River, Matapany River, Matapeneugh River, Mattapanient River, Mattaponie River, Mattapony River, and Riviere de Mattapony.
Residents of the counties surrounding Mattaponi River have debated a proposed reservoir on the Mattaponi River, with environmental groups such as the Sierra Club, members of the Mattaponi Indian tribe, and residents of King William County opposing Newport News Waterworks in their efforts to build the King William Reservoir.