Mayfield first won the Vacant NABO Jr. Welterweight on October 1, 2011 in Tunica, Mississippi, via a 10 round unanimous decision against lefthanded former two-time Venezuelan Olympian Patrick Lopez (20-4).
On June 20, 2015 Floyd Mayweather Jr told ESPN Boxing reporter Dan Rafael[REF] that he was going to fight either Karim Mayfield or Andre Berto next.