The catalytic subunits of protein kinases are highly conserved, and several structures have been solved,[REF] leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [REF].
Eukaryotic protein kinases[REF][REF][REF][REF] are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases.