Tupelo is located in northeast Mississippi, north of Columbus, on Interstate 22/U.S. Route 78, U.S. Route 45, and U.S. Route 278, approximately midway between Memphis, Tennessee (northwest) and Birmingham, Alabama (southeast).
Tupelo has an average annual precipitation of over per year - virtually the highest found anywhere in the eastern U.S. outside isolated highland areas and the immediate Gulf Coast (i.e.