The outcomes of men with moderately differentiated (Gleason scores 5-7) and poorly differentiated (Gleason scores 8-10) cancers managed without treatment (watchful waiting), was compared in the PSA era (1992-2002) and pre PSA era (prior to 1992) [REF].
The Prostate Cancer Intervention versus Observation Trial (PIVOT) randomized 731 men diagnosed with localized prostate cancer to radical prostatectomy or observation (mean age 67 years; median PSA 7.8 ng/ml) [REF].