Expressways passing through Muntinlupa includes South Luzon Expressway, a part of the Pan-Philippine Highway(AH26) Luzon route, Metro Manila Skyway, an elevated expressway running above the South Luzon Expressway from Makati to Muntinlupa, and the Muntinlupa-Cavite Expressway, long access-controlled toll expressway opened on August 2015.
Arterial roads serve as the main route from the national roads to the barangays and its residential and commercial areas.