Syndicated programming seen on KEYE includes Who Wants to Be a Millionaire, Dr. Phil, The 700 Club, The Queen Latifah Show, Two and a Half Men and CSI: Miami among others.
From 2002 to 2008, KEYE held local broadcast rights to Houston Texans pre-season games, in addition to airing CBS' coverage of NFL games from the Texans' home conference, the American Football Conference.