The Caribbean Region covers adjacent to the Caribbean Sea, stretching from the Gulf of Urabá in the west to the Guajira Peninsula in the east and including some or all of the departments of Guajira, Bolívar, Atlántico, Cesar, Magdalena, Sucre, Córdoba, Santander and Antioquia.
The region is traversed by a number of rivers heading from the Andean highlands to the sea, including Colombia's principal river, the Magdalena, which disgorges at the main port of Barranquilla.