The Japanese anime television series The Super Dimension Fortress Macross (1982) featured an ancient, long extinct and very advanced humanoid alien civilization called The Protoculture, who dominated the Milky Way Galaxy by founding a Stellar Republic and who also created the human race on Earth.
The film Prometheus (2012) is themed around a group of scientists who set out to discover the origins of human life, which was seeded on Earth and influenced by an ancient race of aliens.