Alias Smith and Jones was made in the same spirit as many other American TV series of the time, from Huggins' own The Fugitive to Renegade, about fugitives on the run across America who get involved in the personal lives of the people they meet.
The TV series also featured a group of robbers called the Devil's Hole Gang, loosely based on the Hole in the Wall Gang from which Cassidy recruited most of his outlaws.