Based on data from the 2010 United States Census, the population of Lower East Side was 72,957, an increase of 699 (1.0%) from the 72,258 counted in 2000.
The racial makeup of the neighborhood was 22.6% (16,453) White, 10.9% (7,931) African American, 0.2% (142) Native American, 24.9% (18,166) Asian, 0.0% (13) Pacific Islander, 0.3% (191) from other races, and 1.6% (1,191) from two or more races.