Some scholars claim that the earliest example of the Filioque clause in the East is contained in the West Syriac recension of the profession of faith of the Church of the East formulated at the Council of Seleucia-Ctesiphon in Persia in 410.
As early as the 4th century, a distinction was made, in connection with the Trinity, between the two Greek verbs (the verb used in the original Greek text of the 381 Nicene Creed) and .