On 20 October 1545 he was elected alderman for Vintry ward, and on 3 March 1549 was elected Sheriff, and knighted by the young Edward VI.
Lok died 24 August 1550 at his house in Bow Lane, and was buried on 27 August near his parents and his first wife, Alice Spenser, in the Mercers' Church at St Thomas of Acre in London, where his coat of arms was depicted in a window.