U.S. Highway 98 Business was the original segment of US 98 in Panama City, Florida until U.S. Bypass Route 98 was decommissioned in 1979.
While SR 50 takes its sharp left turn toward Weeki Wachee, and SR 50A begins eastbound into downtown Brooksville, Truck Route US 98 continues north along County Road 485, also known as Cobb Road.