Carol Pewterschmidt-West (voiced by Carol Kane in the first appearance, Julie Hagerty in later appearances) - Lois' younger sister and the aunt of Meg, Chris, and Stewie.
Patrick Pewterschmidt (voiced by Robert Downey, Jr. in the first appearance, Oliver Vaquer in the second appearance) - The older brother of Lois and Carol and the uncle of Meg, Chris, and Stewie.