Even while still attending university, Spyros Kokotos worked as a junior architect on the Athens Hilton project, so since graduation he has been mainly involved with tourism projects, having built more than 40 hotels throughout Greece.
Having established a reputation as one of the country's finest architects for hotels, Spyros Kokotos also designed in the late 1960s the Club Med hotel on the island of Kos, the Poseidon Hotel in Loutraki, and the Minos Palace hotel in Aghios Nikolaos, Crete.