It is bounded on the north and east by the Central China Plain, on the west by the Kashmir Region of India and on the south by Nepal, India and Bhutan.
High mountain peaks include Changtse, Lhotse, Makalu, Gauri Sankar, Gurla Mandhata, Cho Oyu, Jomolhari, Gyachung Kang, Gyala Peri, Mount Kailash, Kawagebo, Khumbutse, Melungtse, Mount Nyainqentanglha, Namcha Barwa, Shishapangma and Yangra.