The road begins in the centre of the Thanet town of Margate, at a roundabout with the A28, B2051 and the B2055 along the seafront, where it heads south-eastwards along Eaton Road, passing the Dreamland Amusement Park.
The A254 passes the crossroads with the B2052 and shortly after the Queen Elizabeth The Queen Mother Hospital on the eastern side of the road.