PRTC operates over 100 buses in various Inter-state and Intra-City routes.
It operates various inter-state routes, connecting important cities of Tamil Nadu like Chennai, Coimbatore, Tirunelveli, Nagercoil, Kumily, Velankanni, Nagapattinam, Mayiladuthurai, Neyveli, Chidambaram, Viluppuram, Cuddalore from its towns of Puducherry and Karaikal.