The Siege of Genoa (May 20, 1522 - May 30, 1522) was conducted by an army of the Holy Roman Empire under the command of Spanish General Fernando d'Avalos and Italian condottiero Prospero Colonna against the French forces defending the Italian city.
The Siege of Marseille (August-September 1524) was conducted by an Imperial army under Charles de Bourbon (who had recently betrayed Francis I) and Fernando de Avalos against the French defenders of Marseille.