Mysore district is located between latitude 11°45' to 12°40' N and longitude 75°57' to 77°15' E. It is bounded by Mandya district to the northeast, Chamrajanagar district to the southeast, Kerala state to the south, Kodagu district to the west, and Hassan district to the north.
The district lies on the undulating table land of the southern Deccan plateau, within the watershed of the Kaveri River, which flows through the northwestern and eastern parts of the district.