For nucleoside (nucleobase + ribose sugar) synthesis, Orgel suggested an almost opposite approach, heating a mixture of ribose and the purine nucleobases hypoxanthine, adenine, and guanine to dryness in the presence of magnesium ions [REF].
However, the synthesis was later criticized because it only worked most with hypoxanthine, a nucleobase that is not relevant to current life on Earth, and because it was not specific for the ribose sugar and could instead be applied to other sugars.