In 1623, Qin Liangyu assisted Ming forces in suppressing the She-An Rebellion in Sichuan and Guizhou led by She Chongming (奢崇明) and An Bangyan (安邦彥).
In 1630, when Later Jin forces besieged the Ming capital, Beijing, Qin Liangyu led forces from Sichuan to reinforce the capital.