Isidore was beatified in Rome on 2 May 1619, by Pope Paul V. He was canonized nearly three years later by Pope Gregory XV, along with Saints Ignatius of Loyola, Francis Xavier, Teresa of Ávila and Philip Neri, on 12 March 1622 [REF].
In 1696, his relics were moved to the Royal Alcazar of Madrid to intervene on behalf of the health of Charles II of Spain.