A combination of metformin and rosiglitazone was released in 2002 and sold as Avandamet by GlaxoSmithKline [REF].
DPP-4 inhibitors combined with metformin include a sitagliptin/metformin combination (Janumet) and a saxagliptin combination (Komboglyze/Kombiglyze), and with alogliptin as Kazano.