Eduard Topchjan made his debut with the Armenian Philharmonic Orchestra in 2000, when an orchestra composed of the Serenade Chamber Orchestra musicians and a group of leading APO musicians had an appearance at Bad Fussing Festival, Germany.
In autumn 2006 the APO led by Eduard Topchjan participated in the 41st International Music Festival Moravian Autumn held in Brno, Czech Republic and continued the tour visiting also Prague, Bratislava and Nuremberg (Germany).