His other work in this field includes elucidation of the mechanism of action of corticotropin (ACTH) in regulating steroid hormone synthesis in the adrenal cortex,[REF][REF] regulation of adrenal steroidogenic capacity in disease states,[REF] and the cloning and elucidation of the structure of ACTH receptor [REF].
By their collaborative work that also included additional labs, the Hanukoglu brothers discovered that the severe forms of pseudohypoaldosteronism type I result from mutations in three genes (SCNN1A, SCNN1B, and SCNN1B) that encode for protein subunits of the Epithelial sodium (Na+) channel (ENaC) [REF].