When St Agnes' College (as it was originally called) was established in 1962 by the Franciscan Missionaries of Mary, the school had 29 female students and three staff members, including founding Principal Sister Marcionelle (Burtille Hayes).
The original building (now the administrations block) has a long history, having been granted by Governor Evans to a Rooty Hill station master, Captain Minchin, in the 1880s.