In a murine model of a self-limiting pulmonary allergic reaction, MaR1 reduced lung inflammation.
13(S),14(S)-epoxy-maresin inhibits the production of the arachidonic acid metabolite, Leukotriene B4 (LTB4), by directly inactivating the enzyme, Leukotriene-A4 hydrolase, which converts the LTB4 precursor, Leukotriene A4, to LTB4; this effect may contribute to the resolution of inflammatory responses by reducing the production of the proinflammatory mediator, LTB4 [REF].