Being an anthology series with no recurring characters, The Twilight Zone features a wide array of guest stars for each episode, some of whom appeared in multiple episodes.
Character actors who appeared (some more than once) include John Anderson, John Dehner, Betty Garde, Sandra Gould, Nancy Kulp, Celia Lovsky, Eve McVeagh, Nehemiah Persoff, Albert Salmi, Vito Scotti, Olan Soule, Harold J. Stone, and Estelle Winwood.