Though the oncolytic effect of NDV was documented already in the 1950s, the main advances of viruses in cancer therapy came with the advent of reverse genetics technologies [REF][REF] With these new possibilities, studies of modified NDV strains with enhanced cancer treatment properties have been put on the agenda.
The precise way in which the presence of NDV induces tumor cell death remains to be clarified and may show variation regarding the strains of NDV used and which type of cancer is targeted.