Tofo-Sant'Eleuterio lies about 10 km from Teramo, at an elevation of 250 m.
About one mile from the village is the provincial road "Fonte a collina" (from the spring to the hill) which from Fiumicino (a village near San Nicolò a Tordino in the commune of Teramo leads to Sant'Onofrio in the commune of Campli.