Balk and colleagues conducted a literature search in two databases, for English language clinical trials spanning from the years, 1994 to 2006.
Literature review by Broadhurst and Domenico, made earlier than Balk's and Kleefstra's work, is much more optimistic for Cr efficacy, in the form of chromium picolinate, [Cr(Pic)3], for the treatment of type 2 diabetes.