During the early part of his career, Sackville resided and held office in Essex, where he was Justice of the Peace from 1513 to 1524, and a Commissioner for the Subsidy in 1523 and 1524, but after his father's death in 1524 his career was confined to Sussex and Surrey.
Sackville resided for the latter part of his life at Chiddingly, Sussex, where on 1 July 1556 he made his last will, requesting a requiem Mass at his funeral, and bequeathing money to the poor in five villages in Sussex and Mount Bures in Essex.