The region was settled around 1829, although the part currently within the city of Binghamton was settled around 1802 and called "Chenango Point".
The town of Binghamton was formed in 1855 from a part of the town of Chenango, but part of the new town was lost when the village of Binghamton was first incorporated in 1834, leading in 1867, to the city of Binghamton.