The name "Pokemouche" comes from the Mi'kmaq language word "Pokomújpetúák" in the Francis-Smith orthography, pronounced , (Pogomu'jpetu'a'g in the Listuguj orthography, Pokomu:jpetu:a:k in the orthography of the Lexicon, Pogomotjpetoag in the Pacific orthography and Pokŭmooch'-petooāāk in the Rand orthography.
The name Pokemouche can apply to all of the lower valley of the river.