Prior to the release of The Avengers in 2012, Marvel ran a series of canon tie in comics entitled "Avengers Prelude: Fury's Big Week", which take place within the Marvel Cinematic Universe.
In Ultimate Mystery an elderly Dr. Samuel Sterns (who is seen in a wheelchair) is amongst a group of younger versions of Earth-616 villains and heroes including Doctor Octopus, Arnim Zola III, Misty Knight, Nathaniel Essex, and Dr. Layla Miller.