At the age of fifteen, with his uncle's help, Biroc began his career in film as a film lab technician with Paragon Labs in Fort Lee, New Jersey in 1918.
In 1952, Biroc began his association with producer-director Robert Aldrich, starting with shooting an episode of The Doctor and moving onto films such as Attack (1956), World for Ransom (1954), The Flight of the Phoenix (1965), and The Longest Yard (1974).