In 1973, David Nelson produced a short-lived, syndicated spin-off entitled Ozzie's Girls, in which Ozzie and Harriet rented the boys' old room to two college students, portrayed by Susan Sennett and Brenda Sykes.
Ozzie's Girls premiered on local stations, including New York's WABC-TV, in September 1973, but was cancelled in September 1974 after one season.