After her husband's death, she became first regent to Seti's heir Siptah jointly with Chancellor Bay, whom some have identified as the Irsu mentioned in the Harris Papyrus.
While it was commonly believed that she ruled Egypt with the aid of Chancellor Bay, a recently published document by Pierre Grandet in a BIFAO 100 (2000) paper shows that Bay was executed on Siptah's orders during Year 5 of this king's reign.