In his sixteenth year he was sent by his father, the logothete Constantine Akropolites the elder, to the court of John III Doukas Vatatzes, emperor of Nicaea, where Akropolites continued his studies under Theodore Hexapterygos and Nicephorus Blemmydes.
In the meantime, Michael, afraid of a new Latin invasion, proposed to Pope Clement IV to reunite the Greek and the Latin Churches; and negotiations ensued which were carried on during the reign of five popes, Clement IV, Gregory X, John XXI, Nicolaus III, and Martin IV.