The county of Santa Cruz and the city of Nogales have 200 properties listed in the National Register of Historic Sites, including Tumacacori National Monument first visited by Father Eusebio Kino in 1691 and Tubac Presidio, established by the Spanish in 1752 on an Indian village site.
The architecturally rich downtown area of Nogales near the Mexican-American border offers a unique opportunity for visitors to experience the downtown border-style shopping setting similar to those from the mid-20th century.