On September 26, starting pitcher Ed Reulbach became the only pitcher in Major League Baseball history to pitch two shutouts on the same day.
On Wednesday, September 23, 1908, while playing for the New York Giants in a game against the Cubs, 19-year-old Fred Merkle committed a base-running error that later became known as "Merkle's Boner" and earned him the nickname of "Bonehead." .