LuPone was born on April 21, 1949, in Northport, New York, on Long Island, the daughter of Angela Louise (née Patti), a college library administrator, and Orlando Joseph LuPone, a school administrator [REF].
LuPone was part of the first graduating class of Juilliard's Drama Division (1968-1972: Group 1),[REF] which also included actors Kevin Kline and David Ogden Stiers [REF].