The A583 runs from the A59 Ring Way in Preston city centre to Blackpool, terminating near the town's North Pier.
Major junctions on the road are the A5085 Blackpool Road at Lea, the A584 at Clifton, the A585 west of Kirkham, the western terminus of the M55 motorway just outside Blackpool where the A5230 also terminates, the A5073/A587 in Marton, and the A584/A586 in Blackpool town centre.