The Deutsche Bank Twin Towers are prominently located at the borders of the city districts of Westend-Süd, the Bahnhofsviertel and the Innenstadt, near a series of parks (Wallanlagen) and the Opernplatz.
The twin towers are part of a chain of high-rise buildings at Mainzer Landstraße which stretches from the Opernplatz in the east to the Platz der Republik in the west.