First field trials were performed on Grand Cayman, the largest island of the Cayman Islands, supported by the Bill and Melinda Gates Foundation, starting in 2009.
In 2011 another field test took place in Brazil in cooperation with the company Moscamed and the University of São Paulo, in which again transgenic Aedes aegypti mosquitoes were released in large numbers and the mosquitoes were reduced by 80-95% [REF].