After Dimitrije Ljubavić and his apprentices Opar and Petar completed printing "Apostol" in Targoviste in 1547, Dimitrije left for Constantinople, where he printed books for the Ecumenical Patriarchate of Constantinople for the next three years.
On his return to Transylvania in 1552, Dimitrije Ljubavić not only took up responsibility for running a school in Brasov but also worked as a writer, printer, publisher, and illustrator of books.