Nizamuddín was elected to the throne of the Kingdom by joint councils of men of Thatta, as well as of the military on the 25th of Rabi' al-awwal, 866 (1461 CE), after the death of his father Jam Sanjar.
In the last part of Nizamuddín's reign, after 1490 CE, a Mughul army under Shah Beg Arghun came from Kandahar and attacked many villages of Chundooha and Sideejuh, invading the towns of Ágrí, Ohándukah, Sibi Sindichah and Kót Máchián.