Bluffton High School sports participate in the Northwest Conference, an athletic body sanctioned by the Ohio High School Athletic Association (OHSAA) which includes the Ada Bulldogs, Allen East Mustangs, Bluffton Pirates, Columbus Grove Bulldogs, Convoy Crestview Knights, Delphos Jefferson Wildcats, Lincolnview Lancers, Paulding Panthers, and Spencerville Bearcats.
On March 2, 2007, five Bluffton University baseball players, as well as their bus driver and his wife, were killed in a chartered motorcoach crash on Interstate 75 near downtown Atlanta, Georgia while en route to a tournament in Sarasota, Florida.