Ptolemy declared war on Laodice's newly crowned son, Seleucus II, in 246 BC, and campaigned with great success (his forces possibly being commanded by Xanthippus of Sparta, aka Xanthippus of Carthage, the mercenary general responsible for defeating a Roman army at Tunis/Bagrades in 255).
In exchange for a peace in 241 BC, Ptolemy was awarded new territories on the northern coast of Syria, including Seleucia Pieria, the port of Antioch.