The story focuses on an orphan named Seiya who was forced to go to the Sanctuary in Greece to obtain the Bronze Cloth of the Pegasus constellation, a protective armor worn by the Greek goddess Athena's 88 warriors known as Saints.
The third and last arc follows how Hades, the Underworld god, is freed from his seal and revives the deceased Gold Saints and the Pope Aries Shion, and alongside some of his 108 Specters, sends them to the Sanctuary to kill Athena.