The origin of the university goes back to Friar Antonio González de Acuña (1620-1682), a Peruvian Bishop who studied theology at the Universidad de San Marcos and founded in 1673 the Seminary Saint Rose of Lima in Caracas named after the first Catholic Saint born in the Americas.
On December 1908, Juan Vicente Gómez came into power with a coup d'état against the government of Cipriano Castro.