The much longer Siberian route started in Moscow as the Vladimir Highway and passed through Murom, Kozmodemyansk, Kazan, Perm, Kungur, Yekaterinburg, Tyumen, Tobolsk, Tara, Kainsk, Tomsk, Yeniseysk and Irkutsk.
In the early 19th century, the route was moved to the south.