The main road through Lobpuri is Route 1 (Phahonyothin Road), which starts in Bangkok, and continues through Lopburi, Chai Nat, Nakhon Sawan, Kamphaeng Phet, Tak, Lampang, Chiang Rai, and the border with Burma at Mae Sai.
Lopburi is served by the Khok Kathiam airport, 9km north of the town.