Half a mile from the start of the bypass and a short distance before the arterial makes a turn eastward to traverse Canandaigua Lake to the southeast, US 20 and NY 5 meet NY 21 at a four-way intersection.
From NY 96A east to the village of Waterloo, a distance of roughly four miles, US 20 and NY 5 become a two lane road and run parallel to the Cayuga-Seneca Canal.