Virtually all current synthesizers and their sound libraries are designed to be played primarily with a keyboard controller, whereby the player often reserves one hand to manipulate the many real-time controls to determine how the instrument sounds, and perhaps using a foot to manipulate an expression pedal.
A few of the many hardware (Yamaha, Roland, Akai, Kurzweill) and software (Native Instruments, Garritan, SampleModeling, Sample Logic, LinPlug) synthesizers provide specific support for wind controllers, and they vary widely with respect to how well they emulate acoustic wind, brass, and string instruments.