The surname "Sclafani" is derived from the Greek "Aesculapii fanum," meaning "Sacred to the god Aesculapius," the Roman god of medicine, implying the Sclafani family has been gifted in the field of medicine and healing since the name's origin.
Giovanni Sclifano was given a castle, Castello Megerio, and its territory by King William I of Sicily to show his gratitude for having Giovanni's support in the conspiracy of Matthew Bonello.