Meadows' most famous movies include: Undercurrent (with Katharine Hepburn), Song of the Thin Man (with William Powell and Myrna Loy), David and Bathsheba (with Gregory Peck, Susan Hayward and Raymond Massey), Lady in the Lake (with Robert Montgomery and Audrey Totter), Enchantment (with David Niven and Teresa Wright).
Among her earliest television appearances, Meadows played reporter Helen Brady in a 1953 episode of Suspense opposite Walter Matthau titled, "F.O.B.