Madame Sul-Te-Wan transitioned into the talkie era with relative ease and continued to appear in high-profile films alongside such prominent film actors as Conrad Nagel, Barbara Stanwyck, Fay Wray, Richard Barthelmess, Jane Wyman, Luise Rainer, Melvyn Douglas, Lucille Ball, Veronica Lake and Claudette Colbert.
In 1937, Sul-Te-Wan was cast in the memorable role of Tituba in the film Maid of Salem, a dramatic retelling of the events surrounding of the Salem Witch Trials of 1692.