Drugs that act as allosteric modulators of GABA receptors (known as GABA analogues or GABAergic drugs) or increase the available amount of GABA typically have relaxing, anti-anxiety, and anti-convulsive effects [REF].
In general, GABA does not cross the blood-brain barrier,[REF] although certain areas of the brain that have no effective blood-brain barrier, such as the periventricular nucleus, can be reached by drugs such as systemically injected GABA [REF].