The SAV001-H vaccine is considered as the first genetically modified version of the killed whole HIV-1 vaccine.
Finally, this genetically modified version of HIV-1, (i.e., HIV-1 virus with nef negative, vpu negative and signal peptide gene replaced with honey bee's) grown in human T-lymphocytes (A3.01 cell line) are collected and purified before inactivating them by AT-2 (aldrithiol-2 or 2,2'-Dipyridyldisulfide) chemical treatment and gamma irradiation.