Once in Otsego County, it traverses an s-curve before veering to the east to follow the southern bank of the Susquehanna River through the town of Oneonta.
Back in the town of Oneonta, the overlap between NY 28 and I-88 continues along the northern bank of the Susquehanna toward the hamlet of Emmons, where the expressway meets County Route 47 (CR 47) at exit 16.