On February 10, 2007, LuPone starred with Audra McDonald in the Los Angeles Opera production of Kurt Weill's opera Rise and Fall of the City of Mahagonny directed by John Doyle [REF].
In 2010, LuPone created the role of Lucia in the original Broadway production of Women on the Verge of a Nervous Breakdown, which opened at the Belasco Theater on November 4, 2010 and closed on January 2, 2011 after 23 preview and 69 regular performances.