Avgerinopoulou has served as Member of the Hellenic Parliament and represents the Prefecture of Elis (Ilia), while from 2009 to 2011 she was a Member of the Hellenic Parliament "at large" (Constituency: State, in Greek: "βουλευτής Επικρατείας".)
In 2014, she was elected as the Chairperson of the United Nations Affairs Committee of the Inter-Parliamentary Union (IPU), due to her extensive knowledge of the UN System, acquired throughout her doctoral studies and her previous parliamentary and professional engagements.