Bianca had five younger brothers from her mother's marriage to her father, a half-brother, Bernardino from her mother's second marriage to Giacomo Feo, and another half-brother from her mother's third and final marriage to Giovanni de' Medici il Popolano.
Bianca's early years were turbulent, marked by the violence, treachery, family rivalry amongst the city-states, and continuous warfare which were salient features of life in Renaissance Italy.