Out of the sixteen high schools ESUHSD operates, Independence services the largest student population, with 3,054 students as of the 2013-2014 school year.
As of the 2008-2009 school year, the pupil-teacher ratio was 21.8 to 1, with 94.4% of teachers being fully credentialed; as of the same time, the full-time equivalent of Independence's teachers is 157.4.