Milas and the surrounding region (the Byzantine theme of Mylasa and Melanoudion) was taken over by the Turks under the command of Menteşe Bey in the late thirteenth century, who gave his name to the beylik (Menteşe) that established its capital in the city.
Milas, together with the entire Beylik of Menteşe was taken over by the Ottoman Empire in 1390.