p53 becomes activated in response to myriad stressors, including but not limited to DNA damage (induced by either UV, IR, or chemical agents such as hydrogen peroxide), oxidative stress,[REF] osmotic shock, ribonucleotide depletion, and deregulated oncogene expression.
The novel molecule MI-63 binds to MDM2 making the action of p53 again possible in situations were p53's function has become inhibited [REF].