Though T-cadherin can mediate weak homophilic adhesion in aggregation assays in vitro, the lack of intracellular domain suggests that Т-cadherin is not involved in stable сеll-сеll adhesion.
Studying signaling effects of low density lipoproteins (LDL) in vascular smooth muscles (VSMCs), T-cadherin was isolated and identified as new LDL receptor using human aortic media and the ligand-blotting method.