Ghiraldini began his career with Petrarca Rugby in his home town of Padua before moving to Rugby Calvisano in 2005 where, as captain, he won the Super 10 (now National Championship of Excellence) in 2008 and was a runner-up with them in 2006.
On 21 May 2014, Ghiraldini moved to England to join Leicester Tigers in the Aviva Premiership from the 2014-15 season [REF].