Durham School, in common with most other schools, offers a varied curriculum at GCSE where students study mathematics, English Language and Literature and science (either the individual physics, chemistry and biology or a double award science course).
Durham School offers a range of subjects to students in Years 7 to 9 that lead into the GCSE programme starting, generally, in Year 10, with the exception of those in set 1 maths, who do their maths GCSE a year early.