According to the jūminhyō (registry) in 2008, 149,139 people were living in Minami-ku.
Sapporo's five wards: Chūō-ku, Toyohira-ku, Kiyota-ku, Nishi-ku, Teine-ku, have boundaries with Minami-ku, and four cities (Chitose, Otaru, Date, Eniwa), two towns (Kimobetsu, Kyōgoku), and a village (Akaigawa) also have boundaries.