The bishopric was established on 1910.08.06 as Diocese of Alexandria / Alexandrin(us), named after its new see Alexandria, Louisiana, on the territory of the suppressed Diocese of Natchitoches (Natchitochensis) (founded in 1853) and the first Bishop of was Augustus Marie Martin.
On 18 October 1976, it was renamed as the Diocese of Alexandria-Shreveport (Alexandrinus-Shreveportuensis).