Among his masterpieces are the frescoes, completed in 1526, in the chapel of St. Catherine of Siena painted for the church of San Domenico (Siena), depicting the saint in ecstasy, fainting as she receives the Eucharist from an angel.
Some of his works, including the Holy Family now in the Pinacoteca, Siena have been mistaken for works of Leonardo da Vinci.