On 25 October 1441, Bianca Maria was married, in a magnificent ceremony at the Abbey of San Sigismondo in Cremona, to Francesco Sforza, a renowned Condottiero and member of the Condottieri Sforza family.
Agnese's many descendants included Caterina Sforza, Bianca Maria Sforza, Empress of the Holy Roman Empire, Gian Galeazzo Sforza, Duke of Milan, Isabella of Naples, and Bona Sforza, Queen consort of Poland.