In 1962, Prine landed a lead role with Earl Holliman in the 28-episode NBC series, The Wide Country, a drama about two brothers who are rodeo performers.
Most recently, Prine has worked with director Quentin Tarantino on an Emmy-winning episode of CSI: Crime Scene Investigation and in Saving Grace with Holly Hunter, Boston Legal, and Six Feet Under, in addition to feature films with Johnny Knoxville.