Natural GnRH was previously prescribed as gonadorelin hydrochloride (Factrel)[REF] and gonadorelin diacetate tetrahydrate (Cystorelin)[REF] for use in treating human diseases.
Its analogue Leuprolide is used for continuous infusion, to treat Breast carcinoma, endometriosis, prostate carcinoma, and following research in the 1980s by researchers, including Dr. Florence Comite of Yale University, it was used to treat precocious puberty [REF].