Forming a parallel street to Vasagatan and Sveavägen, Drottninggatan is intersected by (south to north) Fredsgatan, Jakobsgatan, Herkulesgatan, Vattugatan, Klarabergsgatan, Mäster Samuelsgatan, Bryggargatan, Gamla Brogatan, Kungsgatan, Apelbergsgatan, Olof Palmes Gata, Barnhusgatan, Adolf Fredriks Kyrkogata, Wallingatan, Kammakargatan, Tegnérgatan, Rådmansgatan, Kungstensgatan and Observatoriegatan.
The major part of the street is car-free and lined with numerous stores and shops, one of the largest being the Åhléns City department store.