From the ashes of the once proud mutant haven Genosha, the supervillain Red Skull manages to harness the abilities of the world's most powerful telepath Professor Charles Xavier and the being Onslaught, to enslave thousands, amass an army and broadcasts his message of hate across the world.
Preceding the event in September are the "March to AXIS" tie-ins involving the titles of Captain America, Loki: Agent of Asgard, Magneto and Uncanny Avengers.