In the mid 2000s, Ruffalo appeared as a romantic lead in View From the Top (2002), 13 Going on 30 (2004), Just Like Heaven (2005) and Rumor Has It (2005) [REF].
In 2008, Ruffalo starred as a con man in The Brothers Bloom with Adrien Brody and Rachel Weisz and co-starred with Julianne Moore in Blindness.