The various non-allergic NSAID hypersensitivity syndromes affect 0.5-1.9% of the general population, with AERD affecting about 7% of all asthmatics and about 14% of patients with severe asthma [REF].
The respiratory reactions to aspirin vary in severity, ranging from mild nasal congestion and eye watering to lower respiratory symptoms including wheezing, coughing, an asthma attack, and in rare cases, anaphylaxis.