In contrast to tyramine, hordenine did not produce contraction of isolated rat vas deferens, but a 25 μM concentration of the drug did potentiate its response to submaximal doses of norepinephrine (NE), and inhibited its response to tyramine.
Hordenine has been found to be a potent stimulant of gastrin release in the rat, being essentially equipotent with N-methyltyramine: 83 nM/kg of hordenine (corresponding to ~14 mg/kg of the free base) enhancing gastrin release by ~ 60% [REF].