While assisting Col. Edward Hill in removing Rickohockans from their new settlement at the falls of the James River in 1656, Totopotomoi was killed in what was sometimes later called the Battle of Bloody Run (not to be confused with the 1763 Battle of Bloody Run in Michigan) [REF].
When Bacon's Rebellion erupted, Governor Berkeley's faction sought help from the Pamunkey against the hostile tribes, particularly their erstwhile enemies the Susquehannock.