The large collection of paintings, furniture and statuary has been assembled since the 16th century by the Doria, Pamphilj, Landi and Aldobrandini families now united through marriage and descent under the simplified surname Doria Pamphilj.
The palace was renovated for the marriage of Andrea IV Doria Pamphilj Landi to Princess Leopoldina Maria of Savoy, daughter of Louis Victor, Prince of Carignan and Christine of Hesse-Rotenburg in 1767.