Phenibut acts as an agonist of the GABAB receptor (specifically, a full agonist),[REF] similarly to baclofen and γ-hydroxybutyric acid (GHB),[REF] and at higher doses also of the GABAA receptor [REF].
Subsequent research has found that phenibut also binds to and potently blocks α2δ subunit-containing voltage-gated calcium channels (VGCCs), similarly to gabapentin and pregabalin [REF].