Quickly becoming full and continually operating at full capacity, the Society agreed in March 1800 to permit Dr William Haliday to try the first trials of inoculation and vaccination in Ireland.
A small sub-group of the Society's committee went to England in order to establish high-value trades which the poor should be trained in, and having studied the Lancashire cotton trade, came back to Belfast with the plan of training all inmates in the skills of the same industry.