Black-brown pigment was observed by Johann Heinrich Meckel[REF] in 1847, in the blood and spleen of a person suffering from insanity [REF].
Later, in 1891, T. Carbone and W.H. Brown (1911) published papers linking the degradation of hemoglobin with the production of pigment, describing the malaria pigment as a form of hematin and disproving the widely held idea that it is related to melanin.