On 5 November 1992, Pope John Paul II appointed him Titular Bishop of Zama Minor and Secretary of the Pontifical Council for the Family, where he served until his resignation in April 1996.
In February 2014 Sgreggia named and shamed for Radio Vaticana the new Belgian rules in regard to euthanasia as being monstrous and cruel; Belgium did no longer formally exclude minors the access to this 'last option'.