The first Garndiffaith Rugby side was formed in 1922 and their fixtures then consisted of sides like Caerleon College, Llanhilleth All Blacks and Pontypool Quins (who later became Pontypool United RFC) .
Garndiffaith's top players include Billy Werret, who for five years was reserve inside half to Wick Powell of London Welsh and who went on to Captain Pontypool and Arthur Fynn went on to play at Pontypool and gain a Monmouthshire cap.