Budućnost Podgorica, Napredak Kruševac, Radnički Niš, and Milicionar, were relegated to the Second League of FR Yugoslavia.
The relegated teams were replaced by 2000-01 Second League of FR Yugoslavia champions, Mladost Apatin (North), Zvezdara (East), Mladost Lučani (West) and Rudar Pljevlja (South).