Toxicity studies conducted in dogs and rodents administered oleander extracts by intramuscular injection indicated that, on an equivalent weight basis, doses of an oleander extract with glycosides 10 times those likely to be administered therapeutically to humans are still safe and without any "severe toxicity observed" [REF].
Poisoning and reactions to oleander plants are evident quickly, requiring immediate medical care in suspected or known poisonings of both humans and animals [REF].