In 2011, Santo Domingo launched, in partnership with Dana Alikhani, the fashion venture Muzungu Sisters, which focuses on ethical business practices that allow them support local artisans, buy handmade garments at a fair price and then sell them.
Santo Domingo supports several charity organizations, most notably the Motrice Foundation,[REF] which funds research into cerebral palsy and which her husband Andrea Casiraghi also supports [REF].