Usually the image, whether in sculpture or painting, stands by itself, but in the most famous example, the Madonna della Misericordia altarpiece in Sansepolcro by Piero della Francesca, of 1445-62, the subject is the central panel of a large altarpiece, with a smaller Crucifixion above it, and many other panels.
In Germany an almost identical image was used featuring Saint Ursula, usually holding her attribute of an arrow to avoid confusion [REF].