An adolescent Vietnamese girl with Laron syndrome who was treated with a high dosage of IGF-1 and a gonadotropin-releasing hormone analogue for 3-4 years paradoxically experienced isolated progression of breast development without any other pubertal changes in spite of estrogen levels in the low prepubertal range [REF].
Certain long-acting growth hormone secretagogues, such as CJC-1295[REF] and ibutamoren (MK-677),[REF] are capable of reliably and effectively increasing serum GH and IGF-1 concentrations in humans [REF].