The Dan Slott series took a different approach to the metafiction angle, making use of a concept dating back to Lee and Kirby's early Fantastic Four - that the heroes of the Marvel Universe permit licensed comic-book adaptations of their adventures to be published.
If She-Hulk defeats Deadpool as the final opponent in Marvel vs Capcom 3: Fate of Two Worlds, she will say "You know, if this game were made in 1991, I'd be the one whacking YOU with a health bar."