The basic premise is that Mickey Mouse and his friends run a dinner theater club called the "House of Mouse" in downtown Toontown, which shows Disney cartoons as part of its floor shows.
Each episode explores the comical mishaps of Mickey and his associates running the club, which are used as wraparounds for Disney cartoons (some of which are classic theatrical cartoons from the 1930s, 1940s and 1950s, but most of which are reruns from Mickey Mouse Works).