During their career, Pyx lax have collaborated with many Greek singers and musicians such as George Dalaras, Haris Alexiou, Vasilis Papakonstantinou, Katsimihas Brothers, Lavrentis Machairitsas, Miltiadis Paschalidis, Vasilis Karras, Makis Christodoulopoulos, Sotiria Leonardou, Melina Tanagri, Psarantonis, Lakis Papadopoulos, Domenica, ONAR, Theodosia Tsatsou, Mihalis Tzouganakis, Ilias Makridis and many more.
The biggest number of the band's international collaborations were included in their last studio album Charoumeni Stin Poli Ton Trelon (2003), with most notable songs: Someone Wrote 'Save Me' On a Wall (with Eric Burdon singing lead) and All My Angels Falling (with Marc Almond).