In 1249, Ottokar II of Bohemia granted the land of Mikulov (then called Nikolsburg) and the surrounding area to the Austrian noble Henry I of Liechtenstein.
The vine pest Phylloxera arrived in Šatov in 1890, Mikulov and Dolní Dunajovice in 1900, struck Perná in 1901, and hit Horní Věstonice and Bavory in 1902, devastating the vineyards throughout Moravia.