Primary role of EpoR is to promote proliferation of erythroid progenitor cells and rescue erythroid progenitors from cell death [REF].
It is thought that erythroid differentiation is primarily dependent on the presence and induction of erythroid transcriptional factors such as GATA-1, FOG-1 and EKLF, as well as the suppression of myeloid/lymphoid transcriptional factors such as PU.1 [REF].