At Mansfield US 60 meets Missouri Route 5, which runs south to Ava and has a short concurrency with Route 5 north of Mansfield, after which Route 5 continues north towards Hartville.
William Jefferson Blythe, Jr., father of former president Bill Clinton, died on Route 60 (now Route 114) outside of Sikeston, Missouri after being thrown from his car and drowning in a drainage ditch.