Isaac Luria reinterpreted the whole scheme of Kabbalah in the 16th century, essentially making the second of two different versions of theoretical Kabbalah: the Medieval/Classic/Zoharic (later systemised by Moshe Cordovero directly prior to Luria in Safed), and the Lurianic.
In the Lurianic scheme, Creation is initiated by a primordial radical Divine "self-withdrawal" (Tzimtzum), forming a figurative "empty space/vacuum" (Khalal) in which only an "imprint" (Reshimu) remains of the withdrawn Ein Sof.