Anne was born on 1 June 1455, the eldest daughter and one of the 10 children of Amadeus IX of Savoy and Yolande of France, daughter of King Charles VII of France and Marie of Anjou.
On 11 September 1478 in Milan, she married Frederick of Aragon, Prince of Squillace, Altamura and Tarento (1452-1504), the future King Frederick IV of Naples.