The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors.
Angptl3 plays a major role in promoting uptake of circulating triglycerides into white adipose tissue in the fed state,[REF] likely through activation by Angptl8, a feeding-induced hepatokine,[REF][REF] to inhibit postprandial LPL activity in cardiac and skeletal muscles,[REF] as suggested by the ANGPTL3-4-8 model [REF].