Actors Ho Sung Pak (Liu Kang), Philip Ahn (Shang Tsung), Elizabeth Malecki (Sonya Blade), Katalin Zamiar (Kitana/Mileena/Jade) and Dan Pesina (Johnny Cage and Scorpion/Sub-Zero/Reptile/Smoke) all left Midway prior to the production of the game due to royalty disputes, and so their respective roles were played by new actors.
Most of the background music tracks from MKII and MK3 remained intact, especially for the CD-ROM versions of the game.