The Kafue Flats stretch for approximately 240 km east to west along the Kafue River from below the Itezhi-Tezhi gap, site of the Itezhi-Tezhi Dam, to Kafue town and the start of the Kafue Gorge.
The Kafue Flats fall within parts of the Itezhi-Tezhi and Mumbwa Districts in Central Province, Kafue District in Lusaka Province and Monze, Namwala and Mazabuka districts in Southern Province.