Willetton is situated between two major east-west routes - Leach Highway (west to the Bull Creek railway station, Kwinana Freeway to Perth's CBD and Fremantle; east to Cannington and Perth Airport) and South Street (west to Murdoch railway station, Murdoch University and Fremantle; east to Canning Vale and Armadale).
Willetton contains the Southlands bus station, where the CircleRoute takes passengers to Murdoch Train Station, Murdoch University and Curtin University, while other bus routes go to Cannington.