The April 1957 OAG showed 21 daily non-stop departures on Braniff International Airways, 15 on American Airlines, 5 on Central Airlines, 4 on Continental Airlines and 3 on TWA.
Great Plains Airlines, a regional airline based in Tulsa, made Will Rogers World Airport a hub in 2001, with non-stop flights to Tulsa, Albuquerque, New Mexico, and Colorado Springs, Colorado and direct or connecting flights to Nashville, Tennessee, Saint Louis, Chicago, and Washington.