Oscar Wilde was baptised within the current parish, at the former St. Mark's Church; St. Ann's now possesses the relevant records after the two parishes were merged.
The church contains memorials to the Irish theologian Alexander Knox; English poet Felicia Hemans, who lived on Dawson Street from 1831; Richard Whately, the "eccentric" Anglican Archbishop of Dublin appointed 1831; and art collector and benefactor Hugh Lane, who created major collections of modern art in Dublin.