Mackenzie Richmond Hill Hospital was founded in 1963 in Vaughan Township as York Central Hospital, close to the suburb of Richmond Hill, and incorporated into Richmond Hill following the amalgamation of the town in 1973.
In 2003, a patient at the hospital contracted Severe acute respiratory syndrome (SARS) from a transferred patient from another hospital in Toronto, which prompted the closing of both the hospital and the adjacent Alexander Mackenzie High School.