Prucalopride, a first in class dihydro-benzofuran-carboxamide, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities [REF].
The observed effects are exerted via highly selective action on 5-HT4 receptors:[REF] prucalopride has >150-fold higher affinity for 5-HT4 receptors than for other receptors [REF].