The unmarked normal route to the Großes Mühlsturzhorn runs from the northwest via the Mayrbergscharte gap and the Stadelhorn (grade II).
Well known climbing tours are the Alte Südkante (grade VII-, first climbed in 1930 by Huber and Mitterer) and the Direkte Südkante (VI/A1 or VIII-, first achieved in 1936 by Anderl Hinterstoißer and Toni Kurz shortly before Kurz's death on the north face of the Eiger).