The main Toronto Transit Commission bus route on Brimley Road is the 21 Brimley, which runs from Steeles Avenue to Eglinton Avenue, stopping on the way through the Scarborough Centre RT station.
From September 1989 to September 1993 Brimley Rd North of Steeles was served by 128A Brimley North from Scarborough Centre to 14th Avenue by the TTC.