Born in Florida, Buenos Aires, Lizio came through the youth ranks at Argentine Primera División club River Plate, making his official debut on 10 November 2007 against Huracán in a 2-1 away loss, playing the full 90 minutes of the game.
After an entire season without play, he returned to the action with the coach Néstor Gorosito, who made him add minutes in a 2-0 away victory over Independiente at the Estadio Monumental Antonio Vespucio Liberti.