"Cheer Down" was used over the closing credits of Lethal Weapon 2. It was then issued as the opening track on the accompanying soundtrack album, released on 10 August 1989 in the United States, and as a single to promote the film there, on 22 August.
In October 1989, "Cheer Down" was included on Harrison's Dark Horse Records compilation album Best of Dark Horse 1976-1989, as the final track.