Amélie's paternal grandparents were Prince Ferdinand Philippe, Duke of Orléans, and Duchess Helena of Mecklenburg-Schwerin. Her maternal grandparents were Prince Antoine, Duke of Montpensier, and the Infanta Luisa Fernanda of Spain.
The Dukes of Orléans and Montpensier were siblings, both sons of Louis-Philippe I, King of the French, and Maria Amalia of the Two Sicilies.