Born at Schloss Bronnbach in Bronnbach, Wertheim am Main, Kingdom of Württemberg, Infanta Marie Anne (or Maria Ana) was the fifth child and second-youngest daughter of deposed usurper Miguel of Portugal and his wife Princess Adelaide of Löwenstein-Wertheim-Rosenberg.
In spite of their straitened circumstances, the daughters of Miguel I made good marriages, some to reigning monarchs and deposed heads of Roman Catholic European dynasties.