Mechanically, the second generation NSX represents a significant departure from the first generation since it features a twin-turbocharged 75-degree DOHC 3.5L V6 engine producing , mated to a three electric motor Sport Hybrid SH-AWD system and a 9-speed dual-clutch transmission (DCT).
Production of the second generation NSX commenced in 2015 at the Honda Performance Manufacturing Center in Marysville, Ohio, which is housed inside Honda's former North American Logistics facility and located in the midst of Honda's existing R&D and production engineering operations.