Following the rise to power of the NSDAP in the 1930s the Jewish population fell victim to acts of repression that in the pre-war era culminated in the vandalisation of the local synagoge in November 1938.
In World War II, owing to the geographical proximity to the French border, Offenburg was either exposed to temporary evacuations during the Battle of France in 1940 or artillery fire towards the final stages of World War II.