In 2007, Venkat Prabhu ventured into film directing with the sports comedy film Chennai 600028, produced by S. P. B. Charan that revolved around a street cricket team from a suburban area in Chennai, with its players being portrayed by 11 newcomers, including his brother Premgi.
His next project, Biriyani (2013), featured Karthi and Hansika Motwani in the lead roles.