The acquisition of the images is very sensitive to the rhythm of the heart and scans of patients with atrial fibrillation, bigeminy or trigeminy will sometimes be of low quality and may not be interpretable.
In patients who have had a previous myocardial infarction or previous coronary artery bypass surgery, the images may be very difficult to interpret and in such cases, the analysis of the scans is performed with the complement of an other imaging modality (such as coronary angiography).