Interstate 280 passes through the southern portion of East Newark, but the entrances to interchange 16 lie in adjacent Harrison, and those for interchange 15B lie in Newark across the William A. Stickel Memorial Bridge over the Passaic River, which is crossed by the Clay Street Bridge.
Newark Broad Street Station is the rail station closest to East Newark, with connections to New Jersey Transit's Montclair-Boonton Line and both branches of the Morris & Essex Lines.