During World War II he went into exile first to the United States where he spoke on the radio through the Voice of America and then, beginning in 1941, to Mexico where he participated with other French refugees in founding the Institut Français d'Amérique Latine (IFAL).
A writer on many varied topics, Jules Romain was elected to the Académie française on 4 April 1946, occupying chair 12 (of 40).