Yūsuf Nehmé was born on 8 March 1889 in Lehfed in Lebanon as the last of seven children to Estephanos Bou Haykal Nehmé and Christina Badawi Hanna Khaled.
Nehmé died of a severe fever that led to a stroke at 7:00 p.m. on 30 August 1938 at the convent in Kfifan.