Dedisimedi was born into the princely family of Mukhrani, the Mukhranbatoni, a collateral branch of the royal house of Kartli.
As Egnatashvili claims, on her marriage into the Jaqeli family she was given the name Dedisimedi-literally, "a mother's hope"-already known in the family earlier: so was named a consort of Kvarkvare IV Jaqeli, who died in 1489.