In other words, even if the bit of the universe observed is the result of a statistical process, the observer can only view one realization of that process, so our observation is statistically insignificant for saying much about the model, unless the observer is careful to include the variance.
In physical cosmology, the common way of dealing with this on the horizon scale and on slightly sub-horizon scales (where the number of occurrences is greater than one but still quite small), is to explicitly include the variance of very small statistical samples (Poisson distribution) when calculating uncertainties [REF].