From east of Sunbury, the Kororoit Creek makes its way down through many suburbs towards its mouth, including the towns and suburbs of Rockbank, Caroline Springs, , , , , Cairnlea, , , , and Altona North.
The creek is traversed by the Melton Highway, east of Melton; the Western Highway and the Western Ring Road, at Ardeer; and the West Gate Freeway and Federation Trail at Brooklyn.