In the United States the meridian 100° west of Greenwich forms the eastern border of the Texas panhandle with Oklahoma (which traces its origin to the Adams-Onís Treaty in 1819 which settled the border between New Spain and the United States between the Red River and Arkansas River).
A sign across U.S. Highway 30 in Cozad, Nebraska, marks the place where the 100th meridian intersects with the routes of the Oregon Trail, Pony Express, transcontinental railroad, and the Lincoln Highway.