Book three features the four protagonists chasing down three of the villains from the first volume, who escaped captivity in volume 2. At the same time, the masterminds of all the evil deeds thus far complete their plans and brainwash all the other students as well as their divine parents.
It is mentioned in the preview for second book that despite the fact that only children of Egyptian, Norse, Japanese, and Greek gods go to Pantheon High, children of Aztec, Indian, Hawaiian and Mesopotamian deities go to rival school Gilgamesh High.