Improperly folded metal proteins, for example, CCS or [[SOD1|Cu/Zn-superoxide dismutase]] (SOD1) present in [[brain]], [[blood]] or other clinical samples, are indicative of [[neurodegenerative diseases]] like Alzheimer's disease or [[Amyotrophic Lateral Sclerosis]] (ALS) [REF].
[[Selenium]] is another important trace element associated with [[glutathione peroxidase]] which is involved in processes of redox-regulation and oxidative stress response [REF].