On 30 June 1932 the first stone was laid of the city of Littoria, subsequently renamed Latina, intended as an additional comune between the existing ones of Cisterna and Terracina.
The parish was instituted on 23 November 1933 by Cardinal Enrico Gasparri, bishop of Velletri; the Salesians of Don Bosco were invited by Pope Pius XI to be responsible for San Marco on the insistence of the population and of Benito Mussolini.