Darzi joined Imperial College London in 1994, obtained his Professorship in 1996 and became the Chair of Surgery and Head of Department in 1998.
Darzi was educated in Ireland, awarded an MD from Trinity College Dublin and the Fellowships of essentially all the Royal Colleges of Surgeons in the British Isles (Ireland FRCSI, England FRCS, and both Scottish Colleges FRCSEd, FRCPSG).