Meanwhile, Dr. Cristina Yang (Sandra Oh) and Dr. Owen Hunt (Kevin McKidd)'s relationship is still strained after Hunt's posttraumatic stress disorder (PTSD) caused him to strangle Yang while they were sleeping.
When Dr. Bailey (Chandra Wilson) and Derek cannot find any tumor in Izzie's brain from the MRI, they decide to map her brain while she hallucinates and they discover an inoperable tumor.