Corporate Airlines Flight 1566 crashed short of the runway on approach to Kirksville Regional Airport in 2004 after its fatigued pilots had been on their sixth consecutive day of flight and on duty for 14 hours that day.
Captain and first officer on Northwest Airlines Flight 188 in October 2009, fell asleep and remained unresponsive for ninety minutes causing them to overfly their destination by 150 nautical miles [REF].