As with most Venetian palaces, the Cà Grande (Great House) of Saint Samuel is built as two main superposed floors, but unlike other palaces, each floor is accessed by its own independent entrance hall, stairway and porta d'acqua (water door).
The architectural development of the "Cà Grande di San Samuele" is similar to the traditional evolution of many Venetian palaces, the freedom and the harmony of structures underpinning the vivid rhythms and original fascination of the city.