Anna was born in Trebizond on 6 April 1357, the day before Good Friday,[REF] the eldest daughter and child of Emperor Alexios III of Trebizond and Theodora Kantakouzene [REF].
In April 1362, a delegation that included megas logothetes George, the Scholaris, the Sebastos and the historian Michael Panaretos went to Constantinople, to negotiate her betrothal to Andronikos Palaiologos who would later rule as Byzantine Emperor Andronikos IV [REF].