Melvin H. Knisely was an American physiologist who first observed the pathological clumping of red blood cells which are also called what?
Melvin H. Knisely Melvin Henry Knisely (17 June 1904 - 30 March 1975), was an American physiologist who first observed the pathological clumping of red and white cells, in vivo, at the capillary level. One of the most cited Knisely works was his research which documented the fact that even one alcoholic drink kills brain cells, which are irreplaceable.
Waldenström's macroglobulinemia Waldenström's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of cancer affecting two types of B cells, lymphoplasmacytoid cells and plasma cells. Both cell types are white blood cells. WM is characterized by having high levels of a circulating antibody, immunoglobulin M (IgM), which is made and secreted by the cells involved in the disease. WM is an "indolent lymphoma" (i.e., one that tends to grow and spread slowly) and a type of lymphoproliferative disease which shares clinical characteristics with the indolent non-Hodgkin lymphomas. WM is commonly classified as a form of plasma cell dyscrasia. Similar to other plasma cell dyscrasias that, for example, lead to  multiple myeloma, WM is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance (i.e. IgM MGUS) and smoldering Waldenström's macroglobulinemia. The WM spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphpplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms.