Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis
Balwinder Singh, Ajay K. Parsaik, Michelle M. Mielke, Patricia J. Erwin, David S. Knopman, Ronald C. Petersen, Rosebud O. Roberts
Background/Objective: To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment. Methods: We conducted a comprehensive search of the major databases and hand-searched proceedings of major neurology, psychiatry, and dementia conferences through November 2012. Prospective cohort studies examining the MeDi with longitudinal follow-up of at least 1 year and reporting cognitive outcomes (mild cognitive impairment [MCI] or Alzheimer's disease [AD]) were included. The effect size was estimated as hazard-ratio (HR) with 95% confidence intervals (CIs) using the random-effects model. Heterogeneity was assessed using Cochran's Q-test and I2-statistic. Results: Out of the 664 studies screened, five studies met eligibility criteria. Higher adherence to the MeDi was associated with reduced risk of MCI and AD. The subjects in the highest MeDi tertile had 33% less risk (adjusted HR = 0.67; 95% CI, 0.55-0.81; p <0.0001) of cognitive impairment (MCI or AD) as compared to the lowest MeDi score tertile. Among cognitively normal individuals, higher adherence to the MeDi was associated with a reduced risk of MCI (HR = 0.73; 95% CI, 0.56-0.96; p = 0.02) and AD (HR = 0.64; 95% CI, 0.46-0.89; p = 0.007). There was no significant heterogeneity in the analyses. Conclusions: While the overall number of studies is small, pooled results suggest that a higher adherence to the MeDi is associated with a reduced risk of developing MCI and AD, and a reduced risk of progressing from MCI to AD. Further prospective-cohort studies with longer follow-up and randomized controlled trials are warranted to consolidate the evidence. Systematic review registration number: PROSPERO 2013: CRD42013003868.
Journal of Alzheimer's Disease
https://doi.org/10.3233/JAD-130830
10.3233/JAD-130830
Dive into the research topics of 'Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis'. Together they form a unique fingerprint.
Mediterranean Diet Medicine & Life Sciences 100%
cognitive impairment Social Sciences 93%
dementia Social Sciences 76%
Cognitive Dysfunction Medicine & Life Sciences 62%
Alzheimer Disease Medicine & Life Sciences 59%
Meta-Analysis Medicine & Life Sciences 56%
Systematic Reviews Medicine & Life Sciences 56%
confidence Social Sciences 28%
Singh, B., Parsaik, A. K., Mielke, M. M., Erwin, P. J., Knopman, D. S., Petersen, R. C., & Roberts, R. O. (2014). Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. Journal of Alzheimer's Disease, 39(2), 271-282. https://doi.org/10.3233/JAD-130830
Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease : A systematic review and meta-analysis. / Singh, Balwinder; Parsaik, Ajay K.; Mielke, Michelle M. et al.
In: Journal of Alzheimer's Disease, Vol. 39, No. 2, 2014, p. 271-282.
Singh, B, Parsaik, AK, Mielke, MM, Erwin, PJ, Knopman, DS, Petersen, RC & Roberts, RO 2014, 'Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis', Journal of Alzheimer's Disease, vol. 39, no. 2, pp. 271-282. https://doi.org/10.3233/JAD-130830
Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC et al. Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. Journal of Alzheimer's Disease. 2014;39(2):271-282. doi: 10.3233/JAD-130830
Singh, Balwinder ; Parsaik, Ajay K. ; Mielke, Michelle M. et al. / Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease : A systematic review and meta-analysis. In: Journal of Alzheimer's Disease. 2014 ; Vol. 39, No. 2. pp. 271-282.
@article{b609c62242864a5eae52a592c4ad390c,
title = "Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis",
abstract = "Background/Objective: To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment. Methods: We conducted a comprehensive search of the major databases and hand-searched proceedings of major neurology, psychiatry, and dementia conferences through November 2012. Prospective cohort studies examining the MeDi with longitudinal follow-up of at least 1 year and reporting cognitive outcomes (mild cognitive impairment [MCI] or Alzheimer's disease [AD]) were included. The effect size was estimated as hazard-ratio (HR) with 95% confidence intervals (CIs) using the random-effects model. Heterogeneity was assessed using Cochran's Q-test and I2-statistic. Results: Out of the 664 studies screened, five studies met eligibility criteria. Higher adherence to the MeDi was associated with reduced risk of MCI and AD. The subjects in the highest MeDi tertile had 33% less risk (adjusted HR = 0.67; 95% CI, 0.55-0.81; p <0.0001) of cognitive impairment (MCI or AD) as compared to the lowest MeDi score tertile. Among cognitively normal individuals, higher adherence to the MeDi was associated with a reduced risk of MCI (HR = 0.73; 95% CI, 0.56-0.96; p = 0.02) and AD (HR = 0.64; 95% CI, 0.46-0.89; p = 0.007). There was no significant heterogeneity in the analyses. Conclusions: While the overall number of studies is small, pooled results suggest that a higher adherence to the MeDi is associated with a reduced risk of developing MCI and AD, and a reduced risk of progressing from MCI to AD. Further prospective-cohort studies with longer follow-up and randomized controlled trials are warranted to consolidate the evidence. Systematic review registration number: PROSPERO 2013: CRD42013003868.",
keywords = "Alzheimer's disease, Mediterranean diet, meta-analysis, mild cognitive impairment, systematic review",
author = "Balwinder Singh and Parsaik, {Ajay K.} and Mielke, {Michelle M.} and Erwin, {Patricia J.} and Knopman, {David S.} and Petersen, {Ronald C.} and Roberts, {Rosebud O.}",
doi = "10.3233/JAD-130830",
journal = "Journal of Alzheimer's Disease",
publisher = "IOS Press",
T1 - Association of Mediterranean diet with mild cognitive impairment and Alzheimer's disease
T2 - A systematic review and meta-analysis
AU - Singh, Balwinder
AU - Parsaik, Ajay K.
AU - Mielke, Michelle M.
AU - Erwin, Patricia J.
AU - Knopman, David S.
AU - Petersen, Ronald C.
AU - Roberts, Rosebud O.
N2 - Background/Objective: To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment. Methods: We conducted a comprehensive search of the major databases and hand-searched proceedings of major neurology, psychiatry, and dementia conferences through November 2012. Prospective cohort studies examining the MeDi with longitudinal follow-up of at least 1 year and reporting cognitive outcomes (mild cognitive impairment [MCI] or Alzheimer's disease [AD]) were included. The effect size was estimated as hazard-ratio (HR) with 95% confidence intervals (CIs) using the random-effects model. Heterogeneity was assessed using Cochran's Q-test and I2-statistic. Results: Out of the 664 studies screened, five studies met eligibility criteria. Higher adherence to the MeDi was associated with reduced risk of MCI and AD. The subjects in the highest MeDi tertile had 33% less risk (adjusted HR = 0.67; 95% CI, 0.55-0.81; p <0.0001) of cognitive impairment (MCI or AD) as compared to the lowest MeDi score tertile. Among cognitively normal individuals, higher adherence to the MeDi was associated with a reduced risk of MCI (HR = 0.73; 95% CI, 0.56-0.96; p = 0.02) and AD (HR = 0.64; 95% CI, 0.46-0.89; p = 0.007). There was no significant heterogeneity in the analyses. Conclusions: While the overall number of studies is small, pooled results suggest that a higher adherence to the MeDi is associated with a reduced risk of developing MCI and AD, and a reduced risk of progressing from MCI to AD. Further prospective-cohort studies with longer follow-up and randomized controlled trials are warranted to consolidate the evidence. Systematic review registration number: PROSPERO 2013: CRD42013003868.
AB - Background/Objective: To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment. Methods: We conducted a comprehensive search of the major databases and hand-searched proceedings of major neurology, psychiatry, and dementia conferences through November 2012. Prospective cohort studies examining the MeDi with longitudinal follow-up of at least 1 year and reporting cognitive outcomes (mild cognitive impairment [MCI] or Alzheimer's disease [AD]) were included. The effect size was estimated as hazard-ratio (HR) with 95% confidence intervals (CIs) using the random-effects model. Heterogeneity was assessed using Cochran's Q-test and I2-statistic. Results: Out of the 664 studies screened, five studies met eligibility criteria. Higher adherence to the MeDi was associated with reduced risk of MCI and AD. The subjects in the highest MeDi tertile had 33% less risk (adjusted HR = 0.67; 95% CI, 0.55-0.81; p <0.0001) of cognitive impairment (MCI or AD) as compared to the lowest MeDi score tertile. Among cognitively normal individuals, higher adherence to the MeDi was associated with a reduced risk of MCI (HR = 0.73; 95% CI, 0.56-0.96; p = 0.02) and AD (HR = 0.64; 95% CI, 0.46-0.89; p = 0.007). There was no significant heterogeneity in the analyses. Conclusions: While the overall number of studies is small, pooled results suggest that a higher adherence to the MeDi is associated with a reduced risk of developing MCI and AD, and a reduced risk of progressing from MCI to AD. Further prospective-cohort studies with longer follow-up and randomized controlled trials are warranted to consolidate the evidence. Systematic review registration number: PROSPERO 2013: CRD42013003868.
KW - Alzheimer's disease
KW - Mediterranean diet
KW - meta-analysis
KW - mild cognitive impairment
KW - systematic review
U2 - 10.3233/JAD-130830
DO - 10.3233/JAD-130830
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease