The city's name was historically written as 那古野 or 名護屋 (both read as "Nagoya"). One possible origin is the adjective , meaning 'peaceful'. 

The name Chūkyō (中京, consisting of "chū" (middle) + "kyō" (capital)) is also used to refer to Nagoya. Notable examples of the use of the name Chūkyō include the Chūkyō Industrial Area, Chūkyō Metropolitan Area, Chūkyō Television Broadcasting, Chukyo University and the Chukyo Racecourse. 

Oda Nobunaga and his protégés Toyotomi Hideyoshi and Tokugawa Ieyasu were powerful warlords based in the Nagoya area who gradually succeeded in unifying Japan. In 1610, Tokugawa Ieyasu moved the capital of Owari Province from Kiyosu, about seven kilometers () away, to a more strategic location in present-day Nagoya. 

During this period Nagoya Castle was constructed, built partly from materials taken from Kiyosu Castle. During the construction, the entire town around Kiyosu Castle, consisting of around 60,000 people, moved from Kiyosu to the newly planned town around Nagoya Castle. Around the same time, the nearby ancient Atsuta Shrine was designated as a , called Miya (the Shrine), on the important Tōkaidō road, which linked the two capitals of Kyoto and Edo (now Tokyo). A town developed around the temple to support travelers. The castle and shrine towns formed the city.
What happened to it?
moved from Kiyosu to the newly planned town around Nagoya Castle