This article lists aircraft accidents and incidents which resulted in at least 50 fatalities in a single occurrence involving commercial passenger and cargo flights, military passenger and cargo flights, or general aviation flights that have been involved in a ground or mid-air collision with either a commercial or military passenger or cargo flight. 

There have been 539 such accidents, including terrorist or other attacks. Of these, 198 have involved at least 100 fatalities, 33 have had at least 200 fatalities, 8 have had at least 300 fatalities, and 4 accidents have had at least 500 fatalities. Between 1923 (the first year an aircraft accident or incident exceeded 50 fatalities) and the present, these accidents have involved 571 aircraft across all seven continents and the three largest oceans, and have accounted for 56,669 fatalities. 

Five years after the pioneering flight of the Wright brothers on 17 December 1903, Thomas Selfridge became the first fatality of powered flight while flying as a passenger with Orville Wright during a demonstration of the Wright Model A at Fort Myer, Virginia, on 17 September 1908. Eugène Lefebvre was the first pilot killed in a power airplane in 1909, while the first fatal mid-air collision occurred on 19 June 1912, near Douai, France, killing the pilot of each aircraft. Since the deaths of these early aviation pioneers, the scale of fatal aircraft accidents has increased in proportion to the size and capacity of airplanes.
Was both pilots killed?
killing the pilot of each aircraft. 