A2ML1, Official Symbol A2ML1provided by HGNC Official Full Name alpha-2-macroglobulin like 1provided by HGNC Primary source HGNC:HGNC:23336 See related Ensembl:ENSG00000166535 MIM:610627; AllianceGenome:HGNC:23336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OMS; p170; CPAMD9 Summary This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] Expression Restricted expression toward esophagus (RPKM 190.0) See more Orthologs all Based on that information, is the claim: "A2ML1 is a gene that has been associated with some cases of Noonan syndrome." true, false, or inconclusive?