HPSE2, Official Symbol HPSE2provided by HGNC Official Full Name heparanase 2 (inactive)provided by HGNC Primary source HGNC:HGNC:18374 See related Ensembl:ENSG00000172987 MIM:613469; AllianceGenome:HGNC:18374 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UFS; HPA2; HPR2; UFS1 Summary This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Biased expression in esophagus (RPKM 5.3), prostate (RPKM 4.1) and 13 other tissues See more Orthologs mouse all