UBR5, Official Symbol UBR5provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 5provided by HGNC Primary source HGNC:HGNC:16806 See related Ensembl:ENSG00000104517 MIM:608413; AllianceGenome:HGNC:16806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DD5; EDD; HYD; EDD1 Summary This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.7), lymph node (RPKM 11.2) and 25 other tissues See more Orthologs mouse all