FASN, Official Symbol FASNprovided by HGNC Official Full Name fatty acid synthaseprovided by HGNC Primary source HGNC:HGNC:3594 See related Ensembl:ENSG00000169710 MIM:600212; AllianceGenome:HGNC:3594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAS; OA-519; SDR27X1 Summary The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008] Annotation information Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355). [01 Jun 2018] Expression Biased expression in fat (RPKM 227.7), prostate (RPKM 28.4) and 3 other tissues See more Orthologs mouse all