TFEC, Official Symbol TFECprovided by HGNC Official Full Name transcription factor ECprovided by HGNC Primary source HGNC:HGNC:11754 See related Ensembl:ENSG00000105967 MIM:604732; AllianceGenome:HGNC:11754 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-L Summary This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] Expression Broad expression in kidney (RPKM 6.5), appendix (RPKM 6.1) and 17 other tissues See more Orthologs mouse all