ACSL5, Official Symbol ACSL5provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 5provided by HGNC Primary source HGNC:HGNC:16526 See related Ensembl:ENSG00000197142 MIM:605677; AllianceGenome:HGNC:16526 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS2; ACS5; FACL5; DIAR13 Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues See more Orthologs mouse all