RGS11, Official Symbol RGS11provided by HGNC Official Full Name regulator of G protein signaling 11provided by HGNC Primary source HGNC:HGNC:9993 See related Ensembl:ENSG00000076344 MIM:603895; AllianceGenome:HGNC:9993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RS11 Summary The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013] Expression Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues See more Orthologs mouse all