TAB3, Official Symbol TAB3provided by HGNC Official Full Name TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC Primary source HGNC:HGNC:30681 See related Ensembl:ENSG00000157625 MIM:300480; AllianceGenome:HGNC:30681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAP1; MAP3K7IP3 Summary The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues See more Orthologs mouse all