PER3, Official Symbol PER3provided by HGNC Official Full Name period circadian regulator 3provided by HGNC Primary source HGNC:HGNC:8847 See related Ensembl:ENSG00000049246 MIM:603427; AllianceGenome:HGNC:8847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIG13; FASPS3 Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in thyroid (RPKM 14.6), fat (RPKM 11.2) and 24 other tissues See more Orthologs mouse all