ADAMTS1, Official Symbol ADAMTS1provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 1provided by HGNC Primary source HGNC:HGNC:217 See related Ensembl:ENSG00000154734 MIM:605174; AllianceGenome:HGNC:217 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3-C5; METH1 Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 126.2), placenta (RPKM 77.2) and 17 other tissues See more Orthologs mouse all