LIN28A, Official Symbol LIN28Aprovided by HGNC Official Full Name lin-28 homolog Aprovided by HGNC Primary source HGNC:HGNC:15986 See related Ensembl:ENSG00000131914 MIM:611043; AllianceGenome:HGNC:15986 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A Summary This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015] Expression Restricted expression toward testis (RPKM 1.6) See more Orthologs mouse all