EIF2B1, Official Symbol EIF2B1provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit alphaprovided by HGNC Primary source HGNC:HGNC:3257 See related Ensembl:ENSG00000111361 MIM:606686; AllianceGenome:HGNC:3257 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM1; EIF2B; EIF2BA; EIF2Balpha Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in lymph node (RPKM 22.1), skin (RPKM 20.5) and 25 other tissues See more Orthologs mouse all