SORD, Official Symbol SORDprovided by HGNC Official Full Name sorbitol dehydrogenaseprovided by HGNC Primary source HGNC:HGNC:11184 See related Ensembl:ENSG00000140263 MIM:182500; AllianceGenome:HGNC:11184 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDH; SDH; XDH; SORD1; SORDD; HEL-S-95n Summary Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] Expression Biased expression in thyroid (RPKM 163.1), liver (RPKM 161.4) and 11 other tissues See more Orthologs mouse all