PKP3, Official Symbol PKP3provided by HGNC Official Full Name plakophilin 3provided by HGNC Primary source HGNC:HGNC:9025 See related Ensembl:ENSG00000184363 MIM:605561; AllianceGenome:HGNC:9025 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] Expression Biased expression in skin (RPKM 51.4), esophagus (RPKM 46.7) and 11 other tissues See more Orthologs mouse all