PDE4D, Official Symbol PDE4Dprovided by HGNC Official Full Name phosphodiesterase 4Dprovided by HGNC Primary source HGNC:HGNC:8783 See related Ensembl:ENSG00000113448 MIM:600129; AllianceGenome:HGNC:8783 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2 Summary This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009] Expression Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues See more Orthologs mouse all