RCAN1, Official Symbol RCAN1provided by HGNC Official Full Name regulator of calcineurin 1provided by HGNC Primary source HGNC:HGNC:3040 See related Ensembl:ENSG00000159200 MIM:602917; AllianceGenome:HGNC:3040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78 Summary The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] Expression Broad expression in liver (RPKM 56.9), placenta (RPKM 30.5) and 22 other tissues See more Orthologs mouse all