CFP, Official Symbol CFPprovided by HGNC Official Full Name complement factor properdinprovided by HGNC Primary source HGNC:HGNC:8864 See related Ensembl:ENSG00000126759 MIM:300383; AllianceGenome:HGNC:8864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BFD; PFC; PFD; PROPERDIN Summary This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] Expression Biased expression in spleen (RPKM 27.2), bone marrow (RPKM 22.4) and 5 other tissues See more Orthologs mouse all