CAMK2A, Official Symbol CAMK2Aprovided by HGNC Official Full Name calcium/calmodulin dependent protein kinase II alphaprovided by HGNC Primary source HGNC:HGNC:1460 See related Ensembl:ENSG00000070808 MIM:114078; AllianceGenome:HGNC:1460 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha Summary The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018] Expression Restricted expression toward brain (RPKM 112.2) See more Orthologs mouse all