ADAMTS7, Official Symbol ADAMTS7provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 7provided by HGNC Primary source HGNC:HGNC:223 See related Ensembl:ENSG00000136378 MIM:605009; AllianceGenome:HGNC:223 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADAM-TS7; ADAMTS-7; ADAM-TS 7 Summary The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016] Expression Broad expression in endometrium (RPKM 4.6), heart (RPKM 3.1) and 20 other tissues See more Orthologs mouse all