LRRC8D, Official Symbol LRRC8Dprovided by HGNC Official Full Name leucine rich repeat containing 8 VRAC subunit Dprovided by HGNC Primary source HGNC:HGNC:16992 See related Ensembl:ENSG00000171492 MIM:612890; AllianceGenome:HGNC:16992 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC5; HsLRRC8D Summary Enables volume-sensitive anion channel activity. Involved in cellular response to osmotic stress; organic acid transport; and protein hexamerization. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. Part of ion channel complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 8.5), brain (RPKM 8.2) and 25 other tissues See more Orthologs mouse all