RELB, Official Symbol RELBprovided by HGNC Official Full Name RELB proto-oncogene, NF-kB subunitprovided by HGNC Primary source HGNC:HGNC:9956 See related Ensembl:ENSG00000104856 MIM:604758; AllianceGenome:HGNC:9956 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IREL; I-REL; IMD53; REL-B Summary Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 14.1), appendix (RPKM 10.1) and 25 other tissues See more Orthologs mouse all