PF4, Official Symbol PF4provided by HGNC Official Full Name platelet factor 4provided by HGNC Primary source HGNC:HGNC:8861 See related Ensembl:ENSG00000163737 MIM:173460; AllianceGenome:HGNC:8861 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PF-4; CXCL4; SCYB4 Summary This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014] Expression Biased expression in bone marrow (RPKM 14.3), spleen (RPKM 2.7) and 1 other tissue See more Orthologs mouse all