IRX5, Official Symbol IRX5provided by HGNC Official Full Name iroquois homeobox 5provided by HGNC Primary source HGNC:HGNC:14361 See related Ensembl:ENSG00000176842 MIM:606195; AllianceGenome:HGNC:14361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HMMS; IRXB2; IRX-2a Summary This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Biased expression in lung (RPKM 4.8), skin (RPKM 3.3) and 10 other tissues See more Orthologs mouse all