APPBP2, Official Symbol APPBP2provided by HGNC Official Full Name amyloid beta precursor protein binding protein 2provided by HGNC Primary source HGNC:HGNC:622 See related Ensembl:ENSG00000062725 MIM:605324; AllianceGenome:HGNC:622 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAT1; APP-BP2; HS.84084 Summary The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in testis (RPKM 16.4), brain (RPKM 11.4) and 25 other tissues See more Orthologs mouse all