ARFGEF2, Official Symbol ARFGEF2provided by HGNC Official Full Name ADP ribosylation factor guanine nucleotide exchange factor 2provided by HGNC Primary source HGNC:HGNC:15853 See related Ensembl:ENSG00000124198 MIM:605371; AllianceGenome:HGNC:15853 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIG2; PVNH2; dJ1164I10.1 Summary ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 19.9), adrenal (RPKM 14.6) and 25 other tissues See more Orthologs mouse all