PENK, Official Symbol PENKprovided by HGNC Official Full Name proenkephalinprovided by HGNC Primary source HGNC:HGNC:8831 See related Ensembl:ENSG00000181195 MIM:131330; AllianceGenome:HGNC:8831 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PE; PENK-A Summary This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015] Expression Biased expression in adrenal (RPKM 200.5), testis (RPKM 60.4) and 1 other tissue See more Orthologs mouse all