HOXB6, Official Symbol HOXB6provided by HGNC Official Full Name homeobox B6provided by HGNC Primary source HGNC:HGNC:5117 See related Ensembl:ENSG00000108511 MIM:142961; AllianceGenome:HGNC:5117 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX2; HU-2; HOX2B; Hox-2.2 Summary This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 11.8), colon (RPKM 5.2) and 9 other tissues See more Orthologs mouse all