PDGFA, Official Symbol PDGFAprovided by HGNC Official Full Name platelet derived growth factor subunit Aprovided by HGNC Primary source HGNC:HGNC:8799 See related Ensembl:ENSG00000197461 MIM:173430; AllianceGenome:HGNC:8799 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDGF1; PDGF-A Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in lung (RPKM 8.8), placenta (RPKM 8.7) and 24 other tissues See more Orthologs mouse all