EBI3, Official Symbol EBI3provided by HGNC Official Full Name Epstein-Barr virus induced 3provided by HGNC Primary source HGNC:HGNC:3129 See related Ensembl:ENSG00000105246 MIM:605816; AllianceGenome:HGNC:3129 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL27B; IL35B; IL-27B Summary This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008] Expression Biased expression in placenta (RPKM 82.3), spleen (RPKM 9.3) and 2 other tissues See more Orthologs mouse all