IFI30, Official Symbol IFI30provided by HGNC Official Full Name IFI30 lysosomal thiol reductaseprovided by HGNC Primary source HGNC:HGNC:5398 See related Ensembl:ENSG00000216490 MIM:604664; AllianceGenome:HGNC:5398 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GILT; IP30; IP-30; IFI-30 Summary The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 362.8), lung (RPKM 227.6) and 16 other tissues See more Orthologs mouse all