LCT, Official Symbol LCTprovided by HGNC Official Full Name lactaseprovided by HGNC Primary source HGNC:HGNC:6530 See related Ensembl:ENSG00000115850 MIM:603202; AllianceGenome:HGNC:6530 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAC; LPH; LPH1 Summary The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood. [provided by RefSeq, Jan 2016] Expression Biased expression in duodenum (RPKM 121.7) and small intestine (RPKM 73.8) See more Orthologs mouse all