ORAI1, Official Symbol ORAI1provided by HGNC Official Full Name ORAI calcium release-activated calcium modulator 1provided by HGNC Primary source HGNC:HGNC:25896 See related MIM:610277; AllianceGenome:HGNC:25896 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD9; TAM2; ORAT1; CRACM1; TMEM142A Summary The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in skin (RPKM 16.4), duodenum (RPKM 14.8) and 25 other tissues See more Orthologs mouse all