TRIM27, Official Symbol TRIM27provided by HGNC Official Full Name tripartite motif containing 27provided by HGNC Primary source HGNC:HGNC:9975 See related Ensembl:ENSG00000204713 MIM:602165; AllianceGenome:HGNC:9975 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RFP; RNF76 Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 14.7), spleen (RPKM 14.3) and 25 other tissues See more Orthologs mouse all