SLC12A5, Official Symbol SLC12A5provided by HGNC Official Full Name solute carrier family 12 member 5provided by HGNC Primary source HGNC:HGNC:13818 See related Ensembl:ENSG00000124140 MIM:606726; AllianceGenome:HGNC:13818 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KCC2; DEE34; EIG14; hKCC2; EIEE34 Summary K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008] Expression Restricted expression toward brain (RPKM 26.0) See more Orthologs mouse all