TGFBRAP1, Official Symbol TGFBRAP1provided by HGNC Official Full Name transforming growth factor beta receptor associated protein 1provided by HGNC Primary source HGNC:HGNC:16836 See related Ensembl:ENSG00000135966 MIM:606237; AllianceGenome:HGNC:16836 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VPS3; TRAP1; TRAP-1 Summary This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016] Expression Ubiquitous expression in bone marrow (RPKM 7.3), thyroid (RPKM 6.4) and 25 other tissues See more Orthologs mouse all