GGCT, Official Symbol GGCTprovided by HGNC Official Full Name gamma-glutamylcyclotransferaseprovided by HGNC Primary source HGNC:HGNC:21705 See related Ensembl:ENSG00000006625 MIM:137170; AllianceGenome:HGNC:21705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GGC; GCTG; CRF21; C7orf24 Summary The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in skin (RPKM 24.5), colon (RPKM 21.5) and 25 other tissues See more Orthologs mouse all