PDIA2, Official Symbol PDIA2provided by HGNC Official Full Name protein disulfide isomerase family A member 2provided by HGNC Primary source HGNC:HGNC:14180 See related Ensembl:ENSG00000185615 MIM:608012; AllianceGenome:HGNC:14180 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDI; PDA2; PDIP; PDIR Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017] Expression Biased expression in pancreas (RPKM 284.3) and stomach (RPKM 33.5) See more Orthologs mouse all