SFRP1, Official Symbol SFRP1provided by HGNC Official Full Name secreted frizzled related protein 1provided by HGNC Primary source HGNC:HGNC:10776 See related Ensembl:ENSG00000104332 MIM:604156; AllianceGenome:HGNC:10776 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRP; FRP1; FrzA; FRP-1; SARP2 Summary This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] Expression Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues See more Orthologs mouse all