HSPH1, Official Symbol HSPH1provided by HGNC Official Full Name heat shock protein family H (Hsp110) member 1provided by HGNC Primary source HGNC:HGNC:16969 See related Ensembl:ENSG00000120694 MIM:610703; AllianceGenome:HGNC:16969 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSP105; HSP105A; HSP105B; NY-CO-25 Summary This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017] Expression Broad expression in brain (RPKM 32.5), testis (RPKM 30.3) and 25 other tissues See more Orthologs mouse all