SELP, Official Symbol SELPprovided by HGNC Official Full Name selectin Pprovided by HGNC Primary source HGNC:HGNC:10721 See related Ensembl:ENSG00000174175 MIM:173610; AllianceGenome:HGNC:10721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM Summary This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] Expression Broad expression in urinary bladder (RPKM 9.3), appendix (RPKM 7.3) and 20 other tissues See more Orthologs mouse all