CFD, Official Symbol CFDprovided by HGNC Official Full Name complement factor Dprovided by HGNC Primary source HGNC:HGNC:2771 See related Ensembl:ENSG00000197766 MIM:134350; AllianceGenome:HGNC:2771 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DF; ADN; PFD; ADIPSIN Summary This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015] Expression Biased expression in fat (RPKM 584.9), colon (RPKM 88.4) and 1 other tissue See more Orthologs mouse all