LDOC1, Official Symbol LDOC1provided by HGNC Official Full Name LDOC1 regulator of NFKB signalingprovided by HGNC Primary source HGNC:HGNC:6548 See related Ensembl:ENSG00000182195 MIM:300402; AllianceGenome:HGNC:6548 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mar7; RTL7; BCUR1; Mart7; SIRH7 Summary The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008] Orthologs mouse all