CYP11A1, Official Symbol CYP11A1provided by HGNC Official Full Name cytochrome P450 family 11 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2590 See related Ensembl:ENSG00000140459 MIM:118485; AllianceGenome:HGNC:2590 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP11A; CYPXIA1; P450SCC Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 261.9), placenta (RPKM 29.0) and 1 other tissue See more Orthologs mouse all