BMPR1B, Official Symbol BMPR1Bprovided by HGNC Official Full Name bone morphogenetic protein receptor type 1Bprovided by HGNC Primary source HGNC:HGNC:1077 See related Ensembl:ENSG00000138696 MIM:603248; AllianceGenome:HGNC:1077 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALK6; AMD3; AMDD; BDA2; ALK-6; BDA1D; CDw293 Summary This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] Expression Biased expression in prostate (RPKM 14.5), brain (RPKM 5.7) and 7 other tissues See more Orthologs mouse all