TFF2, Official Symbol TFF2provided by HGNC Official Full Name trefoil factor 2provided by HGNC Primary source HGNC:HGNC:11756 See related Ensembl:ENSG00000160181 MIM:182590; AllianceGenome:HGNC:11756 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SP; SML1 Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward stomach (RPKM 2591.2) See more Orthologs mouse all