STAU1, Official Symbol STAU1provided by HGNC Official Full Name staufen double-stranded RNA binding protein 1provided by HGNC Primary source HGNC:HGNC:11370 See related Ensembl:ENSG00000124214 MIM:601716; AllianceGenome:HGNC:11370 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STAU; PPP1R150 Summary Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020] Expression Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues See more Orthologs mouse all