UBA1, Official Symbol UBA1provided by HGNC Official Full Name ubiquitin like modifier activating enzyme 1provided by HGNC Primary source HGNC:HGNC:12469 See related Ensembl:ENSG00000130985 MIM:314370; AllianceGenome:HGNC:12469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; VEXAS; CFAP124 Summary The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 27.6), brain (RPKM 26.8) and 25 other tissues See more Orthologs mouse all