FKBP3, Official Symbol FKBP3provided by HGNC Official Full Name FKBP prolyl isomerase 3provided by HGNC Primary source HGNC:HGNC:3719 See related Ensembl:ENSG00000100442 MIM:186947; AllianceGenome:HGNC:3719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP-3; FKBP25; PPIase; FKBP-25 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues See more Orthologs mouse all