CLDN5, Official Symbol CLDN5provided by HGNC Official Full Name claudin 5provided by HGNC Primary source HGNC:HGNC:2047 See related Ensembl:ENSG00000184113 MIM:602101; AllianceGenome:HGNC:2047 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AWAL; BEC1; TMVCF; TMDVCF; CPETRL1 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018] Expression Biased expression in fat (RPKM 51.6), lung (RPKM 14.0) and 6 other tissues See more Orthologs mouse all