FNIP2, Official Symbol FNIP2provided by HGNC Official Full Name folliculin interacting protein 2provided by HGNC Primary source HGNC:HGNC:29280 See related Ensembl:ENSG00000052795 MIM:612768; AllianceGenome:HGNC:29280 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FNIPL; MAPO1 Summary This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues See more Orthologs mouse all