UBE2B, Official Symbol UBE2Bprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Bprovided by HGNC Primary source HGNC:HGNC:12473 See related Ensembl:ENSG00000119048 MIM:179095; AllianceGenome:HGNC:12473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HR6B; UBC2; HHR6B; RAD6B; E2-17kDa Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 31.0), heart (RPKM 26.8) and 25 other tissues See more Orthologs mouse all