ICAM5, Official Symbol ICAM5provided by HGNC Official Full Name intercellular adhesion molecule 5provided by HGNC Primary source HGNC:HGNC:5348 See related Ensembl:ENSG00000105376 MIM:601852; AllianceGenome:HGNC:5348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLN; TLCN Summary The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue See more Orthologs mouse all