FBLIM1, Official Symbol FBLIM1provided by HGNC Official Full Name filamin binding LIM protein 1provided by HGNC Primary source HGNC:HGNC:24686 See related Ensembl:ENSG00000162458 MIM:607747; AllianceGenome:HGNC:24686 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAL; FBLP1; FBLP-1 Summary This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 17.5), colon (RPKM 14.6) and 22 other tissues See more Orthologs mouse all