PPP1R16A, Official Symbol PPP1R16Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 16Aprovided by HGNC Primary source HGNC:HGNC:14941 See related Ensembl:ENSG00000160972 MIM:609172; AllianceGenome:HGNC:14941 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYPT3 Summary Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020] Expression Broad expression in duodenum (RPKM 18.4), small intestine (RPKM 14.8) and 25 other tissues See more Orthologs mouse all