CHD3, Official Symbol CHD3provided by HGNC Official Full Name chromodomain helicase DNA binding protein 3provided by HGNC Primary source HGNC:HGNC:1918 See related Ensembl:ENSG00000170004 MIM:602120; AllianceGenome:HGNC:1918 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFH; Mi-2a; SNIBCPS; Mi2-ALPHA Summary This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 26.5), brain (RPKM 24.4) and 24 other tissues See more Orthologs mouse all