ACAN, Official Symbol ACANprovided by HGNC Official Full Name aggrecanprovided by HGNC Primary source HGNC:HGNC:319 See related Ensembl:ENSG00000157766 MIM:155760; AllianceGenome:HGNC:319 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; SSOAOD Summary This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 1.8), urinary bladder (RPKM 1.4) and 17 other tissues See more Orthologs mouse all