OGG1, Official Symbol OGG1provided by HGNC Official Full Name 8-oxoguanine DNA glycosylaseprovided by HGNC Primary source HGNC:HGNC:8125 See related Ensembl:ENSG00000114026 MIM:601982; AllianceGenome:HGNC:8125 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HMMH; MUTM; OGH1; HOGG1 Summary This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in kidney (RPKM 5.9), lymph node (RPKM 5.1) and 25 other tissues See more Orthologs mouse all