RTN3, Official Symbol RTN3provided by HGNC Official Full Name reticulon 3provided by HGNC Primary source HGNC:HGNC:10469 See related Ensembl:ENSG00000133318 MIM:604249; AllianceGenome:HGNC:10469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAP; ASYIP; NSPL2; NSPLII; RTN3-A1 Summary This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012] Expression Broad expression in brain (RPKM 157.4), fat (RPKM 54.4) and 23 other tissues See more Orthologs mouse all