YARS1, Official Symbol YARS1provided by HGNC Official Full Name tyrosyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:12840 See related Ensembl:ENSG00000134684 MIM:603623; AllianceGenome:HGNC:12840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YRS; YTS; YARS; TYRRS; CMTDIC; IMNEPD2 Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 25.7), brain (RPKM 24.4) and 25 other tissues See more Orthologs mouse all