DKK2, Official Symbol DKK2provided by HGNC Official Full Name dickkopf WNT signaling pathway inhibitor 2provided by HGNC Primary source HGNC:HGNC:2892 See related Ensembl:ENSG00000155011 MIM:605415; AllianceGenome:HGNC:2892 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKK-2 Summary This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 4.8), ovary (RPKM 3.0) and 14 other tissues See more Orthologs mouse all