NAGPA, Official Symbol NAGPAprovided by HGNC Official Full Name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidaseprovided by HGNC Primary source HGNC:HGNC:17378 See related Ensembl:ENSG00000103174 MIM:607985; AllianceGenome:HGNC:17378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UCE; APAA Summary Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in spleen (RPKM 5.3), stomach (RPKM 4.9) and 25 other tissues See more Orthologs mouse all