PLA2G4A, Official Symbol PLA2G4Aprovided by HGNC Official Full Name phospholipase A2 group IVAprovided by HGNC Primary source HGNC:HGNC:9035 See related Ensembl:ENSG00000116711 MIM:600522; AllianceGenome:HGNC:9035 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GURDP; cPLA2; PLA2G4; cPLA2-alpha Summary This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in urinary bladder (RPKM 6.0), adrenal (RPKM 5.6) and 24 other tissues See more Orthologs mouse all