ZEB2, Official Symbol ZEB2provided by HGNC Official Full Name zinc finger E-box binding homeobox 2provided by HGNC Primary source HGNC:HGNC:14881 See related Ensembl:ENSG00000169554 MIM:605802; AllianceGenome:HGNC:14881 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1 Summary The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] Expression Ubiquitous expression in brain (RPKM 13.4), appendix (RPKM 10.2) and 23 other tissues See more Orthologs mouse all