TUSC3, Official Symbol TUSC3provided by HGNC Official Full Name tumor suppressor candidate 3provided by HGNC Primary source HGNC:HGNC:30242 See related Ensembl:ENSG00000104723 MIM:601385; AllianceGenome:HGNC:30242 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M33; N33; MRT7; MRT22; MagT2; OST3A; D8S1992; SLC58A2 Summary This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017] Expression Broad expression in placenta (RPKM 11.3), adrenal (RPKM 9.7) and 23 other tissues See more Orthologs mouse all