ANKS1B, Official Symbol ANKS1Bprovided by HGNC Official Full Name ankyrin repeat and sterile alpha motif domain containing 1Bprovided by HGNC Primary source HGNC:HGNC:24600 See related Ensembl:ENSG00000185046 MIM:607815; AllianceGenome:HGNC:24600 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2 Summary This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in brain (RPKM 8.0), thyroid (RPKM 1.1) and 21 other tissues See more Orthologs mouse all