NLRP7, Official Symbol NLRP7provided by HGNC Official Full Name NLR family pyrin domain containing 7provided by HGNC Primary source HGNC:HGNC:22947 See related Ensembl:ENSG00000167634 MIM:609661; AllianceGenome:HGNC:22947 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4 Summary This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 2.5), lung (RPKM 0.4) and 7 other tissues See more Orthologs all