ORMDL3, Official Symbol ORMDL3provided by HGNC Official Full Name ORMDL sphingolipid biosynthesis regulator 3provided by HGNC Primary source HGNC:HGNC:16038 See related Ensembl:ENSG00000172057 MIM:610075; AllianceGenome:HGNC:16038 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in ceramide metabolic process. Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and positive regulation of protein localization to nucleus. Located in endoplasmic reticulum. Part of SPOTS complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 53.9), liver (RPKM 33.4) and 25 other tissues See more Orthologs mouse all