UBR4, Official Symbol UBR4provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 4provided by HGNC Primary source HGNC:HGNC:30313 See related Ensembl:ENSG00000127481 MIM:609890; AllianceGenome:HGNC:30313 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p600; ZUBR1; RBAF600 Summary The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 21.2), bone marrow (RPKM 14.0) and 25 other tissues See more Orthologs mouse all