CEMIP2, Official Symbol CEMIP2provided by HGNC Official Full Name cell migration inducing hyaluronidase 2provided by HGNC Primary source HGNC:HGNC:11869 See related Ensembl:ENSG00000135048 MIM:605835; AllianceGenome:HGNC:11869 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMEM2 Summary This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017] Expression Broad expression in placenta (RPKM 42.4), gall bladder (RPKM 25.8) and 23 other tissues See more Orthologs mouse all