ADCY5, Official Symbol ADCY5provided by HGNC Official Full Name adenylate cyclase 5provided by HGNC Primary source HGNC:HGNC:236 See related Ensembl:ENSG00000173175 MIM:600293; AllianceGenome:HGNC:236 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC5; FDFM; DSKOD Summary This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Broad expression in heart (RPKM 22.9), brain (RPKM 7.3) and 17 other tissues See more Orthologs mouse all