MYOC, Official Symbol MYOCprovided by HGNC Official Full Name myocilinprovided by HGNC Primary source HGNC:HGNC:7610 See related Ensembl:ENSG00000034971 MIM:601652; AllianceGenome:HGNC:7610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPOA; JOAG; TIGR; GLC1A; JOAG1 Summary MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 41.3), stomach (RPKM 12.2) and 8 other tissues See more Orthologs mouse all