TAC3, Official Symbol TAC3provided by HGNC Official Full Name tachykinin precursor 3provided by HGNC Primary source HGNC:HGNC:11521 See related Ensembl:ENSG00000166863 MIM:162330; AllianceGenome:HGNC:11521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NK3; NKB; HH10; NKNB; PRO1155; ZNEUROK1; LncZBTB39 Summary This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] Expression Restricted expression toward placenta (RPKM 93.9) See more Orthologs mouse all