PAPOLG, Official Symbol PAPOLGprovided by HGNC Official Full Name poly(A) polymerase gammaprovided by HGNC Primary source HGNC:HGNC:14982 See related Ensembl:ENSG00000115421 MIM:616865; AllianceGenome:HGNC:14982 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 5.8), testis (RPKM 3.7) and 25 other tissues See more Orthologs mouse all