SIRT2, Official Symbol SIRT2provided by HGNC Official Full Name sirtuin 2provided by HGNC Primary source HGNC:HGNC:10886 See related Ensembl:ENSG00000068903 MIM:604480; AllianceGenome:HGNC:10886 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2; SIR2L; SIR2L2 Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues See more Orthologs mouse all