MDM1, Official Symbol MDM1provided by HGNC Official Full Name Mdm1 nuclear proteinprovided by HGNC Primary source HGNC:HGNC:29917 See related Ensembl:ENSG00000111554 MIM:613813; AllianceGenome:HGNC:29917 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019] Expression Broad expression in testis (RPKM 7.9), endometrium (RPKM 4.1) and 24 other tissues See more Orthologs mouse all