GLDC, Official Symbol GLDCprovided by HGNC Official Full Name glycine decarboxylaseprovided by HGNC Primary source HGNC:HGNC:4313 See related Ensembl:ENSG00000178445 MIM:238300; AllianceGenome:HGNC:4313 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCE; GCE1; GCSP; HYGN1 Summary Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010] Expression Biased expression in kidney (RPKM 25.8), placenta (RPKM 17.4) and 4 other tissues See more Orthologs mouse all