MAP2K6, Official Symbol MAP2K6provided by HGNC Official Full Name mitogen-activated protein kinase kinase 6provided by HGNC Primary source HGNC:HGNC:6846 See related Ensembl:ENSG00000108984 MIM:601254; AllianceGenome:HGNC:6846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3 Summary This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues See more Orthologs mouse all