IFNLR1, Official Symbol IFNLR1provided by HGNC Official Full Name interferon lambda receptor 1provided by HGNC Primary source HGNC:HGNC:18584 See related Ensembl:ENSG00000185436 MIM:607404; AllianceGenome:HGNC:18584 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1 Summary The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in small intestine (RPKM 5.6), lymph node (RPKM 4.0) and 22 other tissues See more Orthologs mouse all