LIN28B, Official Symbol LIN28Bprovided by HGNC Official Full Name lin-28 homolog Bprovided by HGNC Primary source HGNC:HGNC:32207 See related Ensembl:ENSG00000187772 MIM:611044; AllianceGenome:HGNC:32207 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSDD2 Summary The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012] Expression Restricted expression toward placenta (RPKM 24.7) See more Orthologs mouse all