MTNR1A, Official Symbol MTNR1Aprovided by HGNC Official Full Name melatonin receptor 1Aprovided by HGNC Primary source HGNC:HGNC:7463 See related Ensembl:ENSG00000168412 MIM:600665; AllianceGenome:HGNC:7463 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MEL-1A-R Summary This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 1.1), testis (RPKM 0.6) and 8 other tissues See more Orthologs mouse all