PDE8A, Official Symbol PDE8Aprovided by HGNC Official Full Name phosphodiesterase 8Aprovided by HGNC Primary source HGNC:HGNC:8793 See related Ensembl:ENSG00000073417 MIM:602972; AllianceGenome:HGNC:8793 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HsT19550 Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] Expression Ubiquitous expression in colon (RPKM 9.5), kidney (RPKM 8.2) and 25 other tissues See more Orthologs mouse all