SOST, Official Symbol SOSTprovided by HGNC Official Full Name sclerostinprovided by HGNC Primary source HGNC:HGNC:13771 See related Ensembl:ENSG00000167941 MIM:605740; AllianceGenome:HGNC:13771 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDD; VBCH; DAND6; SOST1 Summary Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008] Expression Restricted expression toward kidney (RPKM 7.5) See more Orthologs mouse all