OPA1, Official Symbol OPA1provided by HGNC Official Full Name OPA1 mitochondrial dynamin like GTPaseprovided by HGNC Primary source HGNC:HGNC:8140 See related Ensembl:ENSG00000198836 MIM:605290; AllianceGenome:HGNC:8140 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPG; NTG; MGM1; BERHS; largeG; MTDPS14 Summary The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in brain (RPKM 20.5), heart (RPKM 17.2) and 25 other tissues See more Orthologs mouse all