PPM1B, Official Symbol PPM1Bprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Bprovided by HGNC Primary source HGNC:HGNC:9276 See related Ensembl:ENSG00000138032 MIM:603770; AllianceGenome:HGNC:9276 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 9.6), brain (RPKM 8.7) and 25 other tissues See more Orthologs mouse all