ACADSB, Official Symbol ACADSBprovided by HGNC Official Full Name acyl-CoA dehydrogenase short/branched chainprovided by HGNC Primary source HGNC:HGNC:91 See related Ensembl:ENSG00000196177 MIM:600301; AllianceGenome:HGNC:91 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACAD7; SBCAD; 2-MEBCAD Summary Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 72.3), kidney (RPKM 32.5) and 16 other tissues See more Orthologs mouse all