CD86, Official Symbol CD86provided by HGNC Official Full Name CD86 moleculeprovided by HGNC Primary source HGNC:HGNC:1705 See related Ensembl:ENSG00000114013 MIM:601020; AllianceGenome:HGNC:1705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B70; B7-2; B7.2; LAB72; CD28LG2 Summary This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011] Expression Broad expression in appendix (RPKM 16.6), lymph node (RPKM 11.0) and 16 other tissues See more Orthologs mouse all