CAV1, Official Symbol CAV1provided by HGNC Official Full Name caveolin 1provided by HGNC Primary source HGNC:HGNC:1527 See related Ensembl:ENSG00000105974 MIM:601047; AllianceGenome:HGNC:1527 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085 Summary The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010] Expression Biased expression in fat (RPKM 322.1), lung (RPKM 308.8) and 13 other tissues See more Orthologs mouse all