TTL, Official Symbol TTLprovided by HGNC Official Full Name tubulin tyrosine ligaseprovided by HGNC Primary source HGNC:HGNC:21586 See related Ensembl:ENSG00000114999 MIM:608291; AllianceGenome:HGNC:21586 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in brain (RPKM 13.3), lung (RPKM 7.4) and 24 other tissues See more Orthologs mouse all