SASH1, Official Symbol SASH1provided by HGNC Official Full Name SAM and SH3 domain containing 1provided by HGNC Primary source HGNC:HGNC:19182 See related Ensembl:ENSG00000111961 MIM:607955; AllianceGenome:HGNC:19182 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUH; DUH1; CAPOK; SH3D6A; dJ323M4.1 Summary This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016] Expression Broad expression in esophagus (RPKM 20.2), fat (RPKM 19.4) and 23 other tissues See more Orthologs mouse all