MX2, Official Symbol MX2provided by HGNC Official Full Name MX dynamin like GTPase 2provided by HGNC Primary source HGNC:HGNC:7533 See related Ensembl:ENSG00000183486 MIM:147890; AllianceGenome:HGNC:7533 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MXB Summary The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 16.5), appendix (RPKM 13.6) and 23 other tissues See more Orthologs all