EPS15, Official Symbol EPS15provided by HGNC Official Full Name epidermal growth factor receptor pathway substrate 15provided by HGNC Primary source HGNC:HGNC:3419 See related Ensembl:ENSG00000085832 MIM:600051; AllianceGenome:HGNC:3419 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AF1P; AF-1P; MLLT5 Summary This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009] Expression Ubiquitous expression in brain (RPKM 29.8), testis (RPKM 29.2) and 25 other tissues See more Orthologs mouse all