FENDRR, Official Symbol FENDRRprovided by HGNC Official Full Name FOXF1 adjacent non-coding developmental regulatory RNAprovided by HGNC Primary source HGNC:HGNC:43894 See related Ensembl:ENSG00000268388 MIM:614975; AllianceGenome:HGNC:43894 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXF1AS1; FOXF1-AS1; lincFOXF1; TCONS_00024240; onco-lncRNA-21 Summary This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015] Expression Biased expression in lung (RPKM 13.0), urinary bladder (RPKM 9.3) and 9 other tissues See more Orthologs mouse all