PSMA2, Official Symbol PSMA2provided by HGNC Official Full Name proteasome 20S subunit alpha 2provided by HGNC Primary source HGNC:HGNC:9531 See related Ensembl:ENSG00000106588 MIM:176842; AllianceGenome:HGNC:9531 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MU; HC3; PSC2; PMSA2 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 64.0), fat (RPKM 48.4) and 25 other tissues See more Orthologs mouse all