EBF3, Official Symbol EBF3provided by HGNC Official Full Name EBF transcription factor 3provided by HGNC Primary source HGNC:HGNC:19087 See related Ensembl:ENSG00000108001 MIM:607407; AllianceGenome:HGNC:19087 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COE3; OE-2; EBF-3; HADDS; O/E-2 Summary This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011] Expression Biased expression in fat (RPKM 8.2), lymph node (RPKM 3.7) and 12 other tissues See more Orthologs mouse all