PTK6, Official Symbol PTK6provided by HGNC Official Full Name protein tyrosine kinase 6provided by HGNC Primary source HGNC:HGNC:9617 See related Ensembl:ENSG00000101213 MIM:602004; AllianceGenome:HGNC:9617 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRK Summary The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Biased expression in esophagus (RPKM 27.3), skin (RPKM 21.0) and 9 other tissues See more Orthologs mouse all