RNF103, Official Symbol RNF103provided by HGNC Official Full Name ring finger protein 103provided by HGNC Primary source HGNC:HGNC:12859 See related Ensembl:ENSG00000239305 MIM:602507; AllianceGenome:HGNC:12859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KF1; KF-1; HKF-1; ZFP103; ZFP-103 Summary The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in bone marrow (RPKM 15.1), small intestine (RPKM 12.4) and 25 other tissues See more Orthologs mouse all