AGAP2, Official Symbol AGAP2provided by HGNC Official Full Name ArfGAP with GTPase domain, ankyrin repeat and PH domain 2provided by HGNC Primary source HGNC:HGNC:16921 See related Ensembl:ENSG00000135439 MIM:605476; AllianceGenome:HGNC:16921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIKE; GGAP2; CENTG1 Summary The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Expression Biased expression in brain (RPKM 36.4), lymph node (RPKM 4.9) and 4 other tissues See more Orthologs mouse all