TRMT12, Official Symbol TRMT12provided by HGNC Official Full Name tRNA methyltransferase 12 homologprovided by HGNC Primary source HGNC:HGNC:26091 See related Ensembl:ENSG00000183665 MIM:611244; AllianceGenome:HGNC:26091 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TYW2; TRM12 Summary Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008] Orthologs mouse all