TGM2, Official Symbol TGM2provided by HGNC Official Full Name transglutaminase 2provided by HGNC Primary source HGNC:HGNC:11778 See related Ensembl:ENSG00000198959 MIM:190196; AllianceGenome:HGNC:11778 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TGC; tTG; G(h); hTG2; TG(C) Summary Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 177.0), endometrium (RPKM 107.6) and 16 other tissues See more Orthologs mouse all