CDKN1C, Official Symbol CDKN1Cprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 1Cprovided by HGNC Primary source HGNC:HGNC:1786 See related Ensembl:ENSG00000129757 MIM:600856; AllianceGenome:HGNC:1786 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BWS; WBS; p57; BWCR; KIP2; p57Kip2 Summary This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] Expression Biased expression in placenta (RPKM 87.0), fat (RPKM 42.6) and 9 other tissues See more Orthologs mouse all