ORC6, Official Symbol ORC6provided by HGNC Official Full Name origin recognition complex subunit 6provided by HGNC Primary source HGNC:HGNC:17151 See related Ensembl:ENSG00000091651 MIM:607213; AllianceGenome:HGNC:17151 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORC6L Summary The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010] Expression Broad expression in testis (RPKM 6.8), bone marrow (RPKM 5.0) and 16 other tissues See more Orthologs mouse all