COIL, Official Symbol COILprovided by HGNC Official Full Name coilinprovided by HGNC Primary source HGNC:HGNC:2184 See related Ensembl:ENSG00000121058 MIM:600272; AllianceGenome:HGNC:2184 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLN80; p80-coilin Summary The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues See more Orthologs mouse all