DPP3, Official Symbol DPP3provided by HGNC Official Full Name dipeptidyl peptidase 3provided by HGNC Primary source HGNC:HGNC:3008 See related Ensembl:ENSG00000254986 MIM:606818; AllianceGenome:HGNC:3008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPPIII Summary This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues See more Orthologs mouse all