DUSP1, Official Symbol DUSP1provided by HGNC Official Full Name dual specificity phosphatase 1provided by HGNC Primary source HGNC:HGNC:3064 See related Ensembl:ENSG00000120129 MIM:600714; AllianceGenome:HGNC:3064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HVH1; MKP1; CL100; MKP-1; PTPN10 Summary The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in gall bladder (RPKM 359.2), prostate (RPKM 315.6) and 24 other tissues See more Orthologs mouse all