PAM, Official Symbol PAMprovided by HGNC Official Full Name peptidylglycine alpha-amidating monooxygenaseprovided by HGNC Primary source HGNC:HGNC:8596 See related Ensembl:ENSG00000145730 MIM:170270; AllianceGenome:HGNC:8596 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAL; PHM; PAM-1 Summary This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Broad expression in heart (RPKM 269.6), adrenal (RPKM 54.3) and 15 other tissues See more Orthologs mouse all