IL27, Official Symbol IL27provided by HGNC Official Full Name interleukin 27provided by HGNC Primary source HGNC:HGNC:19157 See related Ensembl:ENSG00000197272 MIM:608273; AllianceGenome:HGNC:19157 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p28; IL30; IL-27; IL27A; IL-27A; IL27p28 Summary The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 1.5), appendix (RPKM 0.4) and 6 other tissues See more Orthologs mouse all