PADI3, Official Symbol PADI3provided by HGNC Official Full Name peptidyl arginine deiminase 3provided by HGNC Primary source HGNC:HGNC:18337 See related Ensembl:ENSG00000142619 MIM:606755; AllianceGenome:HGNC:18337 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAD3; PDI3; UHS1 Summary This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008] Expression Biased expression in urinary bladder (RPKM 6.9) and esophagus (RPKM 2.4) See more Orthologs mouse all