QPRT, Official Symbol QPRTprovided by HGNC Official Full Name quinolinate phosphoribosyltransferaseprovided by HGNC Primary source HGNC:HGNC:9755 See related Ensembl:ENSG00000103485 MIM:606248; AllianceGenome:HGNC:9755 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as QPRTase; HEL-S-90n Summary This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Broad expression in kidney (RPKM 60.9), liver (RPKM 33.8) and 14 other tissues See more Orthologs mouse all