NCOR2, Official Symbol NCOR2provided by HGNC Official Full Name nuclear receptor corepressor 2provided by HGNC Primary source HGNC:HGNC:7673 See related Ensembl:ENSG00000196498 MIM:600848; AllianceGenome:HGNC:7673 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau Summary This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011] Expression Ubiquitous expression in fat (RPKM 14.9), lung (RPKM 14.3) and 25 other tissues See more Orthologs mouse all