FXYD3, Official Symbol FXYD3provided by HGNC Official Full Name FXYD domain containing ion transport regulator 3provided by HGNC Primary source HGNC:HGNC:4027 See related Ensembl:ENSG00000089356 MIM:604996; AllianceGenome:HGNC:4027 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAT8; PLML Summary This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] Expression Biased expression in colon (RPKM 158.8), stomach (RPKM 51.0) and 10 other tissues See more Orthologs mouse all