WIF1, Official Symbol WIF1provided by HGNC Official Full Name WNT inhibitory factor 1provided by HGNC Primary source HGNC:HGNC:18081 See related Ensembl:ENSG00000156076 MIM:605186; AllianceGenome:HGNC:18081 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WIF-1 Summary The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] Expression Biased expression in lung (RPKM 69.2), brain (RPKM 9.8) and 3 other tissues See more Orthologs mouse all