OVOL2, Official Symbol OVOL2provided by HGNC Official Full Name ovo like zinc finger 2provided by HGNC Primary source HGNC:HGNC:15804 See related Ensembl:ENSG00000125850 MIM:616441; AllianceGenome:HGNC:15804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHED; CHED1; CHED2; PPCD1; ZNF339; EUROIMAGE566589 Summary This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016] Expression Broad expression in stomach (RPKM 6.1), colon (RPKM 3.5) and 15 other tissues See more Orthologs mouse all