PTGIS, Official Symbol PTGISprovided by HGNC Official Full Name prostaglandin I2 synthaseprovided by HGNC Primary source HGNC:HGNC:9603 See related Ensembl:ENSG00000124212 MIM:601699; AllianceGenome:HGNC:9603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP8; PGIS; PTGI; CYP8A1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] Expression Broad expression in urinary bladder (RPKM 26.9), gall bladder (RPKM 23.0) and 16 other tissues See more Orthologs mouse all