CRADD, Official Symbol CRADDprovided by HGNC Official Full Name CASP2 and RIPK1 domain containing adaptor with death domainprovided by HGNC Primary source HGNC:HGNC:2340 See related Ensembl:ENSG00000169372 MIM:603454; AllianceGenome:HGNC:2340 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT34; RAIDD Summary This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in heart (RPKM 3.8), liver (RPKM 2.6) and 25 other tissues See more Orthologs mouse all