CHRNB1, Official Symbol CHRNB1provided by HGNC Official Full Name cholinergic receptor nicotinic beta 1 subunitprovided by HGNC Primary source HGNC:HGNC:1961 See related Ensembl:ENSG00000170175 MIM:100710; AllianceGenome:HGNC:1961 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACHRB; CHRNB; CMS1D; CMS2A; CMS2C; SCCMS Summary The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 6.4), placenta (RPKM 6.0) and 25 other tissues See more Orthologs mouse all