OGT, Official Symbol OGTprovided by HGNC Official Full Name O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by HGNC Primary source HGNC:HGNC:8127 See related Ensembl:ENSG00000147162 MIM:300255; AllianceGenome:HGNC:8127 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC Summary This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues See more Orthologs mouse all