DKK3, Official Symbol DKK3provided by HGNC Official Full Name dickkopf WNT signaling pathway inhibitor 3provided by HGNC Primary source HGNC:HGNC:2893 See related Ensembl:ENSG00000050165 MIM:605416; AllianceGenome:HGNC:2893 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIG; CRRL; REIC Summary This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues See more Orthologs mouse all