MTHFS, Official Symbol MTHFSprovided by HGNC Official Full Name methenyltetrahydrofolate synthetaseprovided by HGNC Primary source HGNC:HGNC:7437 See related Ensembl:ENSG00000136371 MIM:604197; AllianceGenome:HGNC:7437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEDMEHM; HsT19268 Summary The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] Expression Broad expression in liver (RPKM 20.2), kidney (RPKM 14.0) and 23 other tissues See more Orthologs mouse all