MRPL46, Official Symbol MRPL46provided by HGNC Official Full Name mitochondrial ribosomal protein L46provided by HGNC Primary source HGNC:HGNC:1192 See related Ensembl:ENSG00000259494 MIM:611851; AllianceGenome:HGNC:1192 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as mL46; LIECG2; P2ECSL; C15orf4 Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 23.2), adrenal (RPKM 19.9) and 25 other tissues See more Orthologs mouse all