ICAM3, Official Symbol ICAM3provided by HGNC Official Full Name intercellular adhesion molecule 3provided by HGNC Primary source HGNC:HGNC:5346 See related Ensembl:ENSG00000076662 MIM:146631; AllianceGenome:HGNC:5346 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD50; CDW50; ICAM-R Summary The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] Expression Biased expression in bone marrow (RPKM 55.9), spleen (RPKM 28.5) and 12 other tissues See more Orthologs all