KAZN, Official Symbol KAZNprovided by HGNC Official Full Name kazrin, periplakin interacting proteinprovided by HGNC Primary source HGNC:HGNC:29173 See related Ensembl:ENSG00000189337 MIM:618301; AllianceGenome:HGNC:29173 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAZ; C1orf196 Summary This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011] Expression Broad expression in spleen (RPKM 16.3), brain (RPKM 5.1) and 17 other tissues See more Orthologs mouse all