GTF3A, Official Symbol GTF3Aprovided by HGNC Official Full Name general transcription factor IIIAprovided by HGNC Primary source HGNC:HGNC:4662 See related Ensembl:ENSG00000122034 MIM:600860; AllianceGenome:HGNC:4662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AP2; TFIIIA Summary The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 54.8), heart (RPKM 50.8) and 25 other tissues See more Orthologs mouse all