FBXL18, Official Symbol FBXL18provided by HGNC Official Full Name F-box and leucine rich repeat protein 18provided by HGNC Primary source HGNC:HGNC:21874 See related Ensembl:ENSG00000155034 MIM:609084; AllianceGenome:HGNC:21874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Fbl18 Summary The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in brain (RPKM 2.3), fat (RPKM 1.2) and 24 other tissues See more Orthologs mouse all