CRK, Official Symbol CRKprovided by HGNC Official Full Name CRK proto-oncogene, adaptor proteinprovided by HGNC Primary source HGNC:HGNC:2362 See related Ensembl:ENSG00000167193 MIM:164762; AllianceGenome:HGNC:2362 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p38; CRKII Summary This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues See more Orthologs mouse all