P2RX6, Official Symbol P2RX6provided by HGNC Official Full Name purinergic receptor P2X 6provided by HGNC Primary source HGNC:HGNC:8538 See related Ensembl:ENSG00000099957 MIM:608077; AllianceGenome:HGNC:8538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X6; P2XM; P2RXL1 Summary The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009] Expression Broad expression in spleen (RPKM 2.6), brain (RPKM 2.0) and 17 other tissues See more Orthologs mouse all