SRGAP2B, Official Symbol SRGAP2Bprovided by HGNC Official Full Name SLIT-ROBO Rho GTPase activating protein 2Bprovided by HGNC Primary source HGNC:HGNC:35237 See related Ensembl:ENSG00000196369 MIM:614703; AllianceGenome:HGNC:35237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRGAP2L; SRGAP2P2 Summary This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in skin (RPKM 9.5), spleen (RPKM 7.9) and 23 other tissues See more