RIPK3, Official Symbol RIPK3provided by HGNC Official Full Name receptor interacting serine/threonine kinase 3provided by HGNC Primary source HGNC:HGNC:10021 See related Ensembl:ENSG00000129465 MIM:605817; AllianceGenome:HGNC:10021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIP3 Summary The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008] Expression Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues See more Orthologs mouse all