STK39, Official Symbol STK39provided by HGNC Official Full Name serine/threonine kinase 39provided by HGNC Primary source HGNC:HGNC:17717 See related Ensembl:ENSG00000198648 MIM:607648; AllianceGenome:HGNC:17717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCHT; PASK; SPAK Summary This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 10.6), esophagus (RPKM 7.1) and 23 other tissues See more Orthologs mouse all