TTK, Official Symbol TTKprovided by HGNC Official Full Name TTK protein kinaseprovided by HGNC Primary source HGNC:HGNC:12401 See related Ensembl:ENSG00000112742 MIM:604092; AllianceGenome:HGNC:12401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESK; PYT; CT96; MPH1; MPS1; MPS1L1 Summary This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] Expression Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues See more Orthologs mouse all