P4HTM, Official Symbol P4HTMprovided by HGNC Official Full Name prolyl 4-hydroxylase, transmembraneprovided by HGNC Primary source HGNC:HGNC:28858 See related Ensembl:ENSG00000178467 MIM:614584; AllianceGenome:HGNC:28858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM Summary The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 16.9), adrenal (RPKM 14.4) and 25 other tissues See more Orthologs mouse all