JUP, Official Symbol JUPprovided by HGNC Official Full Name junction plakoglobinprovided by HGNC Primary source HGNC:HGNC:6207 See related Ensembl:ENSG00000173801 MIM:173325; AllianceGenome:HGNC:6207 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PG; DP3; PDGB; PKGB; CTNNG; DPIII Summary This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 236.9), esophagus (RPKM 189.1) and 16 other tissues See more Orthologs mouse all