GRK2, Official Symbol GRK2provided by HGNC Official Full Name G protein-coupled receptor kinase 2provided by HGNC Primary source HGNC:HGNC:289 See related Ensembl:ENSG00000173020 MIM:109635; AllianceGenome:HGNC:289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BARK1; ADRBK1; BETA-ARK1 Summary This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] Expression Broad expression in bone marrow (RPKM 91.8), spleen (RPKM 61.9) and 24 other tissues See more Orthologs mouse all