RPS27, Official Symbol RPS27provided by HGNC Official Full Name ribosomal protein S27provided by HGNC Primary source HGNC:HGNC:10416 See related Ensembl:ENSG00000177954 MIM:603702; AllianceGenome:HGNC:10416 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S27; MPS1; eS27; DBA17; MPS-1 Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018] Expression Ubiquitous expression in ovary (RPKM 2236.6), lymph node (RPKM 1431.7) and 25 other tissues See more Orthologs mouse all