GCG, Official Symbol GCGprovided by HGNC Official Full Name glucagonprovided by HGNC Primary source HGNC:HGNC:4191 See related Ensembl:ENSG00000115263 MIM:138030; AllianceGenome:HGNC:4191 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLP1; GLP2; GRPP; GLP-1 Summary The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008] Expression Biased expression in pancreas (RPKM 204.8), small intestine (RPKM 57.7) and 2 other tissues See more Orthologs mouse all