UCHL5, Official Symbol UCHL5provided by HGNC Official Full Name ubiquitin C-terminal hydrolase L5provided by HGNC Primary source HGNC:HGNC:19678 See related Ensembl:ENSG00000116750 MIM:610667; AllianceGenome:HGNC:19678 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UCH37; CGI-70; INO80R; UCH-L5 Summary Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues See more Orthologs mouse all