C3, Official Symbol C3provided by HGNC Official Full Name complement C3provided by HGNC Primary source HGNC:HGNC:1318 See related Ensembl:ENSG00000125730 MIM:120700; AllianceGenome:HGNC:1318 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p Summary Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015] Expression Biased expression in liver (RPKM 1676.7), gall bladder (RPKM 250.0) and 5 other tissues See more Orthologs mouse all