KLRD1, Official Symbol KLRD1provided by HGNC Official Full Name killer cell lectin like receptor D1provided by HGNC Primary source HGNC:HGNC:6378 See related Ensembl:ENSG00000134539 MIM:602894; AllianceGenome:HGNC:6378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD94 Summary Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017] Expression Broad expression in spleen (RPKM 3.3), lung (RPKM 0.9) and 15 other tissues See more Orthologs all