SLC4A4, Official Symbol SLC4A4provided by HGNC Official Full Name solute carrier family 4 member 4provided by HGNC Primary source HGNC:HGNC:11030 See related Ensembl:ENSG00000080493 MIM:603345; AllianceGenome:HGNC:11030 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KNBC; NBC1; NBC2; pNBC; HNBC1; NBCe1; hhNMC; kNBC1; SLC4A5; NBCe1-A Summary This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] Expression Biased expression in kidney (RPKM 56.0), pancreas (RPKM 31.5) and 12 other tissues See more Orthologs mouse all