TIFA, Official Symbol TIFAprovided by HGNC Official Full Name TRAF interacting protein with forkhead associated domainprovided by HGNC Primary source HGNC:HGNC:19075 See related Ensembl:ENSG00000145365 MIM:609028; AllianceGenome:HGNC:19075 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2BP; T6BP; TIFAA Summary This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018] Expression Ubiquitous expression in lymph node (RPKM 11.2), thyroid (RPKM 11.0) and 25 other tissues See more Orthologs mouse all