CHRDL2, Official Symbol CHRDL2provided by HGNC Official Full Name chordin like 2provided by HGNC Primary source HGNC:HGNC:24168 See related Ensembl:ENSG00000054938 MIM:613127; AllianceGenome:HGNC:24168 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BNF1; CHL2 Summary This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015] Expression Biased expression in gall bladder (RPKM 39.8), appendix (RPKM 39.3) and 4 other tissues See more Orthologs mouse all