PVT1, Official Symbol PVT1provided by HGNC Official Full Name Pvt1 oncogeneprovided by HGNC Primary source HGNC:HGNC:9709 See related Ensembl:ENSG00000249859 MIM:165140; AllianceGenome:HGNC:9709 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP53LC09; LINC00079; MIR1204HG; NCRNA00079; onco-lncRNA-100 Summary This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015] Expression Broad expression in ovary (RPKM 3.9), bone marrow (RPKM 3.4) and 21 other tissues See more Orthologs mouse all