CISH, Official Symbol CISHprovided by HGNC Official Full Name cytokine inducible SH2 containing proteinprovided by HGNC Primary source HGNC:HGNC:1984 See related Ensembl:ENSG00000114737 MIM:602441; AllianceGenome:HGNC:1984 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIS; G18; SOCS; CIS-1; BACTS2 Summary The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Broad expression in thyroid (RPKM 9.8), kidney (RPKM 7.3) and 24 other tissues See more Orthologs mouse all