SMC3, Official Symbol SMC3provided by HGNC Official Full Name structural maintenance of chromosomes 3provided by HGNC Primary source HGNC:HGNC:2468 See related Ensembl:ENSG00000108055 MIM:606062; AllianceGenome:HGNC:2468 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1 Summary This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 37.2), bone marrow (RPKM 22.4) and 25 other tissues See more Orthologs mouse all