HSD17B6, Official Symbol HSD17B6provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 6provided by HGNC Primary source HGNC:HGNC:23316 See related Ensembl:ENSG00000025423 MIM:606623; AllianceGenome:HGNC:23316 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSE; RODH; SDR9C6 Summary The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013] Expression Biased expression in liver (RPKM 415.0), lung (RPKM 33.0) and 2 other tissues See more Orthologs mouse all