PDE12, Official Symbol PDE12provided by HGNC Official Full Name phosphodiesterase 12provided by HGNC Primary source HGNC:HGNC:25386 See related Ensembl:ENSG00000174840 MIM:616519; AllianceGenome:HGNC:25386 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 2-PDE; 2'-PDE Summary Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 3.9), thyroid (RPKM 3.9) and 25 other tissues See more Orthologs mouse all