TMED10, Official Symbol TMED10provided by HGNC Official Full Name transmembrane p24 trafficking protein 10provided by HGNC Primary source HGNC:HGNC:16998 See related Ensembl:ENSG00000170348 MIM:605406; AllianceGenome:HGNC:16998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA) Summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 111.9), endometrium (RPKM 61.7) and 25 other tissues See more Orthologs mouse all