PHACTR1, Official Symbol PHACTR1provided by HGNC Official Full Name phosphatase and actin regulator 1provided by HGNC Primary source HGNC:HGNC:20990 See related Ensembl:ENSG00000112137 MIM:608723; AllianceGenome:HGNC:20990 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPEL; DEE70; RPEL1; EIEE70; dJ257A7.2 Summary The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] Expression Biased expression in brain (RPKM 12.6), bone marrow (RPKM 5.8) and 12 other tissues See more Orthologs mouse all