RAPGEF5, Official Symbol RAPGEF5provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 5provided by HGNC Primary source HGNC:HGNC:16862 See related Ensembl:ENSG00000136237 MIM:609527; AllianceGenome:HGNC:16862 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GFR; MRGEF; REPAC; MR-GEF Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] Expression Broad expression in brain (RPKM 18.5), spleen (RPKM 13.5) and 23 other tissues See more Orthologs mouse all