PMAIP1, Official Symbol PMAIP1provided by HGNC Official Full Name phorbol-12-myristate-13-acetate-induced protein 1provided by HGNC Primary source HGNC:HGNC:9108 See related Ensembl:ENSG00000141682 MIM:604959; AllianceGenome:HGNC:9108 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APR; NOXA Summary This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020] Expression Biased expression in bone marrow (RPKM 33.1), placenta (RPKM 8.9) and 12 other tissues See more Orthologs mouse all