HEYL, Official Symbol HEYLprovided by HGNC Official Full Name hes related family bHLH transcription factor with YRPW motif likeprovided by HGNC Primary source HGNC:HGNC:4882 See related Ensembl:ENSG00000163909 MIM:609034; AllianceGenome:HGNC:4882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEY3; HRT3; HESR3; bHLHb33 Summary This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 14.5), placenta (RPKM 14.3) and 23 other tissues See more Orthologs mouse all