LTBP1, Official Symbol LTBP1provided by HGNC Official Full Name latent transforming growth factor beta binding protein 1provided by HGNC Primary source HGNC:HGNC:6714 See related Ensembl:ENSG00000049323 MIM:150390; AllianceGenome:HGNC:6714 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARCL2E Summary The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 40.6), placenta (RPKM 32.5) and 24 other tissues See more Orthologs mouse all