SETD6, Official Symbol SETD6provided by HGNC Official Full Name SET domain containing 6, protein lysine methyltransferaseprovided by HGNC Primary source HGNC:HGNC:26116 See related Ensembl:ENSG00000103037 MIM:616424; AllianceGenome:HGNC:26116 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in testis (RPKM 13.6), skin (RPKM 9.3) and 25 other tissues See more Orthologs mouse all