ARL1, Official Symbol ARL1provided by HGNC Official Full Name ADP ribosylation factor like GTPase 1provided by HGNC Primary source HGNC:HGNC:692 See related Ensembl:ENSG00000120805 MIM:603425; AllianceGenome:HGNC:692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARFL1 Summary The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in thyroid (RPKM 47.8), prostate (RPKM 38.2) and 25 other tissues See more Orthologs mouse all