ARG1, Official Symbol ARG1provided by HGNC Official Full Name arginase 1provided by HGNC Primary source HGNC:HGNC:663 See related Ensembl:ENSG00000118520 MIM:608313; AllianceGenome:HGNC:663 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Biased expression in liver (RPKM 237.4), bone marrow (RPKM 81.9) and 1 other tissue See more Orthologs mouse all