MGAT4A, Official Symbol MGAT4Aprovided by HGNC Official Full Name alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Aprovided by HGNC Primary source HGNC:HGNC:7047 See related Ensembl:ENSG00000071073 MIM:604623; AllianceGenome:HGNC:7047 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNT-IV; GnT-4a; GNT-IVA Summary This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008] Expression Broad expression in small intestine (RPKM 18.3), colon (RPKM 13.7) and 24 other tissues See more Orthologs mouse all