NEDD4, Official Symbol NEDD4provided by HGNC Official Full Name NEDD4 E3 ubiquitin protein ligaseprovided by HGNC Primary source HGNC:HGNC:7727 See related Ensembl:ENSG00000069869 MIM:602278; AllianceGenome:HGNC:7727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPF1; NEDD4-1 Summary This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues See more Orthologs mouse all