CTSH, Official Symbol CTSHprovided by HGNC Official Full Name cathepsin Hprovided by HGNC Primary source HGNC:HGNC:2535 See related Ensembl:ENSG00000103811 MIM:116820; AllianceGenome:HGNC:2535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACC4; ACC5; CPSB; ACC-4; ACC-5 Summary The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Broad expression in lung (RPKM 144.1), kidney (RPKM 97.7) and 24 other tissues See more Orthologs mouse all