ATP1B4, Official Symbol ATP1B4provided by HGNC Official Full Name ATPase Na+/K+ transporting family member beta 4provided by HGNC Primary source HGNC:HGNC:808 See related Ensembl:ENSG00000101892 MIM:301073; AllianceGenome:HGNC:808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Biased expression in prostate (RPKM 1.2), esophagus (RPKM 0.3) and 1 other tissue See more Orthologs mouse all