RSPO4, Official Symbol RSPO4provided by HGNC Official Full Name R-spondin 4provided by HGNC Primary source HGNC:HGNC:16175 See related Ensembl:ENSG00000101282 MIM:610573; AllianceGenome:HGNC:16175 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRISTIN4; C20orf182 Summary This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009] Expression Biased expression in lung (RPKM 1.4), testis (RPKM 0.6) and 7 other tissues See more Orthologs mouse all