IYD, Official Symbol IYDprovided by HGNC Official Full Name iodotyrosine deiodinaseprovided by HGNC Primary source HGNC:HGNC:21071 See related Ensembl:ENSG00000009765 MIM:612025; AllianceGenome:HGNC:21071 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TDH4; IYD-1; DEHAL1; C6orf71 Summary This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Expression Restricted expression toward thyroid (RPKM 256.4) See more Orthologs mouse all