KLF5, Official Symbol KLF5provided by HGNC Official Full Name KLF transcription factor 5provided by HGNC Primary source HGNC:HGNC:6349 See related Ensembl:ENSG00000102554 MIM:602903; AllianceGenome:HGNC:6349 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKLF; IKLF; BTEB2 Summary This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] Expression Broad expression in skin (RPKM 92.1), esophagus (RPKM 91.6) and 14 other tissues See more Orthologs mouse all