CRY1, Official Symbol CRY1provided by HGNC Official Full Name cryptochrome circadian regulator 1provided by HGNC Primary source HGNC:HGNC:2384 See related Ensembl:ENSG00000008405 MIM:601933; AllianceGenome:HGNC:2384 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSPD; PHLL1 Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014] Expression Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues See more Orthologs mouse all