MMS22L, Official Symbol MMS22Lprovided by HGNC Official Full Name MMS22 like, DNA repair proteinprovided by HGNC Primary source HGNC:HGNC:21475 See related Ensembl:ENSG00000146263 MIM:615614; AllianceGenome:HGNC:21475 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf167; dJ39B17.2 Summary The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017] Expression Broad expression in testis (RPKM 2.1), bone marrow (RPKM 1.2) and 24 other tissues See more Orthologs mouse all