CD1D, Official Symbol CD1Dprovided by HGNC Official Full Name CD1d moleculeprovided by HGNC Primary source HGNC:HGNC:1637 See related Ensembl:ENSG00000158473 IMGT/GENE-DB:CD1D; MIM:188410; AllianceGenome:HGNC:1637 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R3; CD1A; R3G1 Summary This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Broad expression in appendix (RPKM 5.0), spleen (RPKM 5.0) and 17 other tissues See more Orthologs mouse all