NFKBIA, Official Symbol NFKBIAprovided by HGNC Official Full Name NFKB inhibitor alphaprovided by HGNC Primary source HGNC:HGNC:7797 See related Ensembl:ENSG00000100906 MIM:164008; AllianceGenome:HGNC:7797 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKBA; MAD-3; NFKBI; EDAID2 Summary This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] Expression Broad expression in bone marrow (RPKM 430.4), ovary (RPKM 112.0) and 21 other tissues See more Orthologs mouse all