HCN2, Official Symbol HCN2provided by HGNC Official Full Name hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2provided by HGNC Primary source HGNC:HGNC:4846 See related Ensembl:ENSG00000099822 MIM:602781; AllianceGenome:HGNC:4846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11 Summary The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017] Expression Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues See more Orthologs mouse all