PLA2G1B, Official Symbol PLA2G1Bprovided by HGNC Official Full Name phospholipase A2 group IBprovided by HGNC Primary source HGNC:HGNC:9030 See related Ensembl:ENSG00000170890 MIM:172410; AllianceGenome:HGNC:9030 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLA2; PLA2A; PPLA2 Summary This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013] Expression Restricted expression toward pancreas (RPKM 9662.9) See more Orthologs mouse all