TLL1, Official Symbol TLL1provided by HGNC Official Full Name tolloid like 1provided by HGNC Primary source HGNC:HGNC:11843 See related Ensembl:ENSG00000038295 MIM:606742; AllianceGenome:HGNC:11843 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLL; ASD6 Summary This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Expression Broad expression in placenta (RPKM 2.3), gall bladder (RPKM 1.2) and 21 other tissues See more Orthologs mouse all