CAND1, Official Symbol CAND1provided by HGNC Official Full Name cullin associated and neddylation dissociated 1provided by HGNC Primary source HGNC:HGNC:30688 See related Ensembl:ENSG00000111530 MIM:607727; AllianceGenome:HGNC:30688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIP120; TIP120A Summary This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in brain (RPKM 22.8), testis (RPKM 22.7) and 25 other tissues See more Orthologs mouse all