TIMP3, Official Symbol TIMP3provided by HGNC Official Full Name TIMP metallopeptidase inhibitor 3provided by HGNC Primary source HGNC:HGNC:11822 See related Ensembl:ENSG00000100234 MIM:188826; AllianceGenome:HGNC:11822 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFD; K222; K222TA2; HSMRK222 Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 485.4), fat (RPKM 420.5) and 18 other tissues See more Orthologs mouse all