EXOC6, Official Symbol EXOC6provided by HGNC Official Full Name exocyst complex component 6provided by HGNC Primary source HGNC:HGNC:23196 See related Ensembl:ENSG00000138190 MIM:609672; AllianceGenome:HGNC:23196 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEC15; EXOC6A; SEC15L; Sec15p; SEC15L1; SEC15L3 Summary The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in thyroid (RPKM 11.4), placenta (RPKM 9.4) and 25 other tissues See more Orthologs mouse all