ADAM22, Official Symbol ADAM22provided by HGNC Official Full Name ADAM metallopeptidase domain 22provided by HGNC Primary source HGNC:HGNC:201 See related Ensembl:ENSG00000008277 MIM:603709; AllianceGenome:HGNC:201 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDC2; DEE61; EIEE61; ADAM 22 Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010] Expression Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues See more Orthologs mouse all