BACE2, Official Symbol BACE2provided by HGNC Official Full Name beta-secretase 2provided by HGNC Primary source HGNC:HGNC:934 See related Ensembl:ENSG00000182240 MIM:605668; AllianceGenome:HGNC:934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1 Summary This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in stomach (RPKM 12.5), gall bladder (RPKM 11.8) and 23 other tissues See more Orthologs mouse all