PTK2, Official Symbol PTK2provided by HGNC Official Full Name protein tyrosine kinase 2provided by HGNC Primary source HGNC:HGNC:9611 See related Ensembl:ENSG00000169398 MIM:600758; AllianceGenome:HGNC:9611 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK Summary This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017] Expression Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues See more Orthologs mouse all