POLD2, Official Symbol POLD2provided by HGNC Official Full Name DNA polymerase delta 2, accessory subunitprovided by HGNC Primary source HGNC:HGNC:9176 See related Ensembl:ENSG00000106628 MIM:600815; AllianceGenome:HGNC:9176 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in heart (RPKM 20.0), ovary (RPKM 19.1) and 25 other tissues See more Orthologs mouse all