TERF2, Official Symbol TERF2provided by HGNC Official Full Name telomeric repeat binding factor 2provided by HGNC Primary source HGNC:HGNC:11729 See related Ensembl:ENSG00000132604 MIM:602027; AllianceGenome:HGNC:11729 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRF2; TRBF2 Summary This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 13.1), lymph node (RPKM 12.7) and 25 other tissues See more Orthologs mouse all