HLA-DPB1, Official Symbol HLA-DPB1provided by HGNC Official Full Name major histocompatibility complex, class II, DP beta 1provided by HGNC Primary source HGNC:HGNC:4940 See related Ensembl:ENSG00000223865 MIM:142858; AllianceGenome:HGNC:4940 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPB1; HLA-DP; HLA-DPB; HLA-DP1B Summary HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 88.0), lymph node (RPKM 85.6) and 22 other tissues See more Orthologs all