TWIST2, Official Symbol TWIST2provided by HGNC Official Full Name twist family bHLH transcription factor 2provided by HGNC Primary source HGNC:HGNC:20670 See related Ensembl:ENSG00000233608 MIM:607556; AllianceGenome:HGNC:20670 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMS; FFDD3; BBRSAY; DERMO1; SETLSS; bHLHa39 Summary The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014] Expression Biased expression in fat (RPKM 11.9), endometrium (RPKM 7.9) and 10 other tissues See more Orthologs mouse all