PTPN3, Official Symbol PTPN3provided by HGNC Official Full Name protein tyrosine phosphatase non-receptor type 3provided by HGNC Primary source HGNC:HGNC:9655 See related Ensembl:ENSG00000070159 MIM:176877; AllianceGenome:HGNC:9655 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTPH1; PTP-H1 Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] Expression Broad expression in skin (RPKM 9.4), kidney (RPKM 7.8) and 21 other tissues See more Orthologs mouse all