FES, Official Symbol FESprovided by HGNC Official Full Name FES proto-oncogene, tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:3657 See related Ensembl:ENSG00000182511 MIM:190030; AllianceGenome:HGNC:3657 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPS Summary This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009] Expression Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues See more Orthologs mouse all