ENTPD7, Official Symbol ENTPD7provided by HGNC Official Full Name ectonucleoside triphosphate diphosphohydrolase 7provided by HGNC Primary source HGNC:HGNC:19745 See related Ensembl:ENSG00000198018 MIM:616753; AllianceGenome:HGNC:19745 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LALP1 Summary This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in small intestine (RPKM 8.2), duodenum (RPKM 8.0) and 25 other tissues See more Orthologs mouse all