CHGA, Official Symbol CHGAprovided by HGNC Official Full Name chromogranin Aprovided by HGNC Primary source HGNC:HGNC:1929 See related Ensembl:ENSG00000100604 MIM:118910; AllianceGenome:HGNC:1929 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGA; PHE5; PHES Summary The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] Expression Biased expression in adrenal (RPKM 574.1), stomach (RPKM 148.9) and 5 other tissues See more Orthologs mouse all