BNIP3, Official Symbol BNIP3provided by HGNC Official Full Name BCL2 interacting protein 3provided by HGNC Primary source HGNC:HGNC:1084 See related Ensembl:ENSG00000176171 MIM:603293; AllianceGenome:HGNC:1084 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIP3; HABON Summary This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues See more Orthologs mouse all