TRPM2, Official Symbol TRPM2provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 2provided by HGNC Primary source HGNC:HGNC:12339 See related Ensembl:ENSG00000142185 MIM:603749; AllianceGenome:HGNC:12339 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1 Summary The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016] Expression Broad expression in bone marrow (RPKM 4.5), brain (RPKM 2.6) and 21 other tissues See more Orthologs mouse all