NEIL3, Official Symbol NEIL3provided by HGNC Official Full Name nei like DNA glycosylase 3provided by HGNC Primary source HGNC:HGNC:24573 See related Ensembl:ENSG00000109674 MIM:608934; AllianceGenome:HGNC:24573 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3 Summary NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008] Expression Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.9) and 13 other tissues See more Orthologs mouse all