LDHB, Official Symbol LDHBprovided by HGNC Official Full Name lactate dehydrogenase Bprovided by HGNC Primary source HGNC:HGNC:6541 See related Ensembl:ENSG00000111716 MIM:150100; AllianceGenome:HGNC:6541 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281 Summary This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016] Expression Broad expression in kidney (RPKM 475.5), heart (RPKM 454.7) and 21 other tissues See more Orthologs mouse all