VPREB1, Official Symbol VPREB1provided by HGNC Official Full Name V-set pre-B cell surrogate light chain 1provided by HGNC Primary source HGNC:HGNC:12709 See related Ensembl:ENSG00000169575 IMGT/GENE-DB:VPREB1; MIM:605141; AllianceGenome:HGNC:12709 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGI; IGVPB; VPREB; CD179a Summary The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Orthologs mouse all