PIM1, Official Symbol PIM1provided by HGNC Official Full Name Pim-1 proto-oncogene, serine/threonine kinaseprovided by HGNC Primary source HGNC:HGNC:8986 See related Ensembl:ENSG00000137193 MIM:164960; AllianceGenome:HGNC:8986 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIM Summary The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011] Expression Broad expression in bone marrow (RPKM 89.3), esophagus (RPKM 60.8) and 21 other tissues See more Orthologs mouse all