EYA3, Official Symbol EYA3provided by HGNC Official Full Name EYA transcriptional coactivator and phosphatase 3provided by HGNC Primary source HGNC:HGNC:3521 See related Ensembl:ENSG00000158161 MIM:601655; AllianceGenome:HGNC:3521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in testis (RPKM 6.3), kidney (RPKM 5.2) and 25 other tissues See more Orthologs mouse all