GIP, Official Symbol GIPprovided by HGNC Official Full Name gastric inhibitory polypeptideprovided by HGNC Primary source HGNC:HGNC:4270 See related Ensembl:ENSG00000159224 MIM:137240; AllianceGenome:HGNC:4270 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008] Expression Biased expression in duodenum (RPKM 96.0) and small intestine (RPKM 33.9) See more Orthologs mouse all