ENPEP, Official Symbol ENPEPprovided by HGNC Official Full Name glutamyl aminopeptidaseprovided by HGNC Primary source HGNC:HGNC:3355 See related Ensembl:ENSG00000138792 MIM:138297; AllianceGenome:HGNC:3355 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APA; CD249; gp160 Summary The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020] Expression Biased expression in small intestine (RPKM 132.9), kidney (RPKM 71.6) and 5 other tissues See more Orthologs mouse all