PROS1, Official Symbol PROS1provided by HGNC Official Full Name protein Sprovided by HGNC Primary source HGNC:HGNC:9456 See related Ensembl:ENSG00000184500 MIM:176880; AllianceGenome:HGNC:9456 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6 Summary This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015] Expression Broad expression in liver (RPKM 79.4), heart (RPKM 44.6) and 21 other tissues See more Orthologs mouse all