DEF6, Official Symbol DEF6provided by HGNC Official Full Name DEF6 guanine nucleotide exchange factorprovided by HGNC Primary source HGNC:HGNC:2760 See related Ensembl:ENSG00000023892 MIM:610094; AllianceGenome:HGNC:2760 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IBP; SLAT; IMD87; SWAP70L Summary DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008] Expression Broad expression in lymph node (RPKM 23.3), bone marrow (RPKM 22.5) and 21 other tissues See more Orthologs mouse all