BIRC5, Official Symbol BIRC5provided by HGNC Official Full Name baculoviral IAP repeat containing 5provided by HGNC Primary source HGNC:HGNC:593 See related Ensembl:ENSG00000089685 MIM:603352; AllianceGenome:HGNC:593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as API4; EPR-1 Summary This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] Expression Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues See more Orthologs mouse all