DOCK1, Official Symbol DOCK1provided by HGNC Official Full Name dedicator of cytokinesis 1provided by HGNC Primary source HGNC:HGNC:2987 See related Ensembl:ENSG00000150760 MIM:601403; AllianceGenome:HGNC:2987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ced5; DOCK180 Summary This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues See more Orthologs mouse all