HMGB3, Official Symbol HMGB3provided by HGNC Official Full Name high mobility group box 3provided by HGNC Primary source HGNC:HGNC:5004 See related Ensembl:ENSG00000029993 MIM:300193; AllianceGenome:HGNC:5004 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HMG4; HMG-4; HMG2A; HMG-2a Summary This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Broad expression in placenta (RPKM 24.9), bone marrow (RPKM 7.8) and 21 other tissues See more Orthologs mouse all