PPIE, Official Symbol PPIEprovided by HGNC Official Full Name peptidylprolyl isomerase Eprovided by HGNC Primary source HGNC:HGNC:9258 See related Ensembl:ENSG00000084072 MIM:602435; AllianceGenome:HGNC:9258 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP33; CYP-33 Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues See more Orthologs mouse all