PYCR1, Official Symbol PYCR1provided by HGNC Official Full Name pyrroline-5-carboxylate reductase 1provided by HGNC Primary source HGNC:HGNC:9721 See related Ensembl:ENSG00000183010 MIM:179035; AllianceGenome:HGNC:9721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P5C; P5CR; PRO3; PYCR; PIG45; PP222; ARCL2B; ARCL3B Summary This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Broad expression in salivary gland (RPKM 19.9), stomach (RPKM 16.0) and 19 other tissues See more Orthologs mouse all