FEM1A, Official Symbol FEM1Aprovided by HGNC Official Full Name fem-1 homolog Aprovided by HGNC Primary source HGNC:HGNC:16934 See related Ensembl:ENSG00000141965 MIM:613538; AllianceGenome:HGNC:16934 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPRAP Summary Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all