ARHGAP8, Official Symbol ARHGAP8provided by HGNC Official Full Name Rho GTPase activating protein 8provided by HGNC Primary source HGNC:HGNC:677 See related Ensembl:ENSG00000241484 MIM:609405; AllianceGenome:HGNC:677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP610; BPGAP1 Summary This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010] Expression Broad expression in kidney (RPKM 6.0), thyroid (RPKM 5.9) and 18 other tissues See more Orthologs mouse all