SHISA3, Official Symbol SHISA3provided by HGNC Official Full Name shisa family member 3provided by HGNC Primary source HGNC:HGNC:25159 See related Ensembl:ENSG00000178343 MIM:617325; AllianceGenome:HGNC:25159 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hShisa3 Summary This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017] Expression Biased expression in kidney (RPKM 14.3), lymph node (RPKM 4.2) and 12 other tissues See more Orthologs mouse all