KDR, Official Symbol KDRprovided by HGNC Official Full Name kinase insert domain receptorprovided by HGNC Primary source HGNC:HGNC:6307 See related Ensembl:ENSG00000128052 MIM:191306; AllianceGenome:HGNC:6307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLK1; CD309; VEGFR; VEGFR2 Summary Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009] Expression Broad expression in placenta (RPKM 44.3), thyroid (RPKM 24.9) and 19 other tissues See more Orthologs mouse all