MAP3K15, Official Symbol MAP3K15provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 15provided by HGNC Primary source HGNC:HGNC:31689 See related Ensembl:ENSG00000180815 MIM:300820; AllianceGenome:HGNC:31689 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASK3; bA723P2.3 Summary The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in adrenal (RPKM 7.5), heart (RPKM 3.2) and 24 other tissues See more Orthologs mouse all