BMAL2, Official Symbol BMAL2provided by HGNC Official Full Name basic helix-loop-helix ARNT like 2provided by HGNC Primary source HGNC:HGNC:18984 See related Ensembl:ENSG00000029153 MIM:614517; AllianceGenome:HGNC:18984 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLIF; MOP9; PASD9; ARNTL2; bHLHe6 Summary This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] Expression Broad expression in esophagus (RPKM 6.4), appendix (RPKM 3.2) and 17 other tissues See more Orthologs mouse all