IRS4, Official Symbol IRS4provided by HGNC Official Full Name insulin receptor substrate 4provided by HGNC Primary source HGNC:HGNC:6128 See related Ensembl:ENSG00000133124 MIM:300904; AllianceGenome:HGNC:6128 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHNG9; IRS-4; PY160 Summary IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008] Expression Biased expression in ovary (RPKM 3.0), thyroid (RPKM 1.0) and 3 other tissues See more Orthologs mouse all