VDAC3, Official Symbol VDAC3provided by HGNC Official Full Name voltage dependent anion channel 3provided by HGNC Primary source HGNC:HGNC:12674 See related Ensembl:ENSG00000078668 MIM:610029; AllianceGenome:HGNC:12674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VDAC-3; HD-VDAC3 Summary This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in heart (RPKM 97.4), testis (RPKM 53.6) and 25 other tissues See more Orthologs mouse all