MAPK7, Official Symbol MAPK7provided by HGNC Official Full Name mitogen-activated protein kinase 7provided by HGNC Primary source HGNC:HGNC:6880 See related Ensembl:ENSG00000166484 MIM:602521; AllianceGenome:HGNC:6880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMK1; ERK4; ERK5; PRKM7 Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues See more Orthologs mouse all