RAC2, Official Symbol RAC2provided by HGNC Official Full Name Rac family small GTPase 2provided by HGNC Primary source HGNC:HGNC:9802 See related Ensembl:ENSG00000128340 MIM:602049; AllianceGenome:HGNC:9802 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gx; EN-7; IMD73A; IMD73B; IMD73C; HSPC022; p21-Rac2 Summary This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013] Expression Biased expression in lymph node (RPKM 157.7), bone marrow (RPKM 130.6) and 9 other tissues See more Orthologs mouse all