LRR1, Official Symbol LRR1provided by HGNC Official Full Name leucine rich repeat protein 1provided by HGNC Primary source HGNC:HGNC:19742 See related Ensembl:ENSG00000165501 MIM:609193; AllianceGenome:HGNC:19742 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRR-1; PPIL5; 4-1BBLRR Summary The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] Expression Broad expression in testis (RPKM 19.8), bone marrow (RPKM 6.1) and 21 other tissues See more Orthologs mouse all