TTC19, Official Symbol TTC19provided by HGNC Official Full Name tetratricopeptide repeat domain 19provided by HGNC Primary source HGNC:HGNC:26006 See related Ensembl:ENSG00000011295 MIM:613814; AllianceGenome:HGNC:26006 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MC3DN2; 2010204O13Rik Summary This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2012] Expression Ubiquitous expression in thyroid (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues See more Orthologs mouse all