MAP3K11, Official Symbol MAP3K11provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 11provided by HGNC Primary source HGNC:HGNC:6850 See related Ensembl:ENSG00000173327 MIM:600050; AllianceGenome:HGNC:6850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLK3; PTK1; SPRK; MLK-3; MEKK11 Summary The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 25.3), fat (RPKM 22.6) and 25 other tissues See more Orthologs mouse all