IGFALS, Official Symbol IGFALSprovided by HGNC Official Full Name insulin like growth factor binding protein acid labile subunitprovided by HGNC Primary source HGNC:HGNC:5468 See related Ensembl:ENSG00000099769 MIM:601489; AllianceGenome:HGNC:5468 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALS; ACLSD Summary The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Biased expression in liver (RPKM 19.9) and stomach (RPKM 3.6) See more Orthologs mouse all