SERPINA3, Official Symbol SERPINA3provided by HGNC Official Full Name serpin family A member 3provided by HGNC Primary source HGNC:HGNC:16 See related Ensembl:ENSG00000196136 MIM:107280; AllianceGenome:HGNC:16 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACT; AACT; GIG24; GIG25 Summary The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jun 2020] Expression Biased expression in liver (RPKM 989.5), gall bladder (RPKM 89.2) and 4 other tissues See more Orthologs all