KANK2, Official Symbol KANK2provided by HGNC Official Full Name KN motif and ankyrin repeat domains 2provided by HGNC Primary source HGNC:HGNC:29300 See related Ensembl:ENSG00000197256 MIM:614610; AllianceGenome:HGNC:29300 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIP; MXRA3; PPKWH; NPHS16; ANKRD25 Summary This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in endometrium (RPKM 77.8), ovary (RPKM 51.9) and 21 other tissues See more Orthologs mouse all