NGEF, Official Symbol NGEFprovided by HGNC Official Full Name neuronal guanine nucleotide exchange factorprovided by HGNC Primary source HGNC:HGNC:7807 See related Ensembl:ENSG00000066248 MIM:605991; AllianceGenome:HGNC:7807 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPHEXIN; ARHGEF27 Summary Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 32.1), duodenum (RPKM 14.9) and 8 other tissues See more Orthologs mouse all