NLRP4, Official Symbol NLRP4provided by HGNC Official Full Name NLR family pyrin domain containing 4provided by HGNC Primary source HGNC:HGNC:22943 See related Ensembl:ENSG00000160505 MIM:609645; AllianceGenome:HGNC:22943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5 Summary The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016] Expression Biased expression in testis (RPKM 3.5), lymph node (RPKM 0.8) and 1 other tissue See more Orthologs all