LMX1A, Official Symbol LMX1Aprovided by HGNC Official Full Name LIM homeobox transcription factor 1 alphaprovided by HGNC Primary source HGNC:HGNC:6653 See related Ensembl:ENSG00000162761 MIM:600298; AllianceGenome:HGNC:6653 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LMX1; DFNA7; LMX1.1 Summary This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] Expression Low expression observed in reference dataset See more Orthologs mouse all