NR1I2, Official Symbol NR1I2provided by HGNC Official Full Name nuclear receptor subfamily 1 group I member 2provided by HGNC Primary source HGNC:HGNC:7968 See related Ensembl:ENSG00000144852 MIM:603065; AllianceGenome:HGNC:7968 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq Summary This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in small intestine (RPKM 14.5), duodenum (RPKM 13.0) and 4 other tissues See more Orthologs mouse all