DISC1, Official Symbol DISC1provided by HGNC Official Full Name DISC1 scaffold proteinprovided by HGNC Primary source HGNC:HGNC:2888 See related Ensembl:ENSG00000162946 MIM:605210; AllianceGenome:HGNC:2888 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCZD9; C1orf136 Summary This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 2.1), ovary (RPKM 1.4) and 24 other tissues See more Orthologs mouse all