MICB, Official Symbol MICBprovided by HGNC Official Full Name MHC class I polypeptide-related sequence Bprovided by HGNC Primary source HGNC:HGNC:7091 See related Ensembl:ENSG00000204516 IMGT/GENE-DB:MICB; MIM:602436; AllianceGenome:HGNC:7091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PERB11.2 Summary This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Broad expression in lymph node (RPKM 4.7), bone marrow (RPKM 4.2) and 20 other tissues See more Orthologs all