HRH2, Official Symbol HRH2provided by HGNC Official Full Name histamine receptor H2provided by HGNC Primary source HGNC:HGNC:5183 See related Ensembl:ENSG00000113749 MIM:142703; AllianceGenome:HGNC:5183 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H2R; HH2R Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues See more Orthologs mouse all