HR, Official Symbol HRprovided by HGNC Official Full Name HR lysine demethylase and nuclear receptor corepressorprovided by HGNC Primary source HGNC:HGNC:5172 See related Ensembl:ENSG00000168453 MIM:602302; AllianceGenome:HGNC:5172 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165 Summary This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] Expression Biased expression in skin (RPKM 28.2), esophagus (RPKM 5.5) and 8 other tissues See more Orthologs mouse all