GGT1, Official Symbol GGT1provided by HGNC Official Full Name gamma-glutamyltransferase 1provided by HGNC Primary source HGNC:HGNC:4250 See related Ensembl:ENSG00000100031 MIM:612346; AllianceGenome:HGNC:4250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GGT; GTG; GGTD; CD224; GGT 1; D22S672; D22S732 Summary The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014] Expression Biased expression in kidney (RPKM 54.5), duodenum (RPKM 22.2) and 11 other tissues See more Orthologs mouse all