SOCS3, Official Symbol SOCS3provided by HGNC Official Full Name suppressor of cytokine signaling 3provided by HGNC Primary source HGNC:HGNC:19391 See related Ensembl:ENSG00000184557 MIM:604176; AllianceGenome:HGNC:19391 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3 Summary This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 130.8), urinary bladder (RPKM 79.6) and 21 other tissues See more Orthologs mouse all