BUB1, Official Symbol BUB1provided by HGNC Official Full Name BUB1 mitotic checkpoint serine/threonine kinaseprovided by HGNC Primary source HGNC:HGNC:1148 See related Ensembl:ENSG00000169679 MIM:602452; AllianceGenome:HGNC:1148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BUB1A; BUB1L; hBUB1; MCPH30 Summary This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Biased expression in testis (RPKM 25.2), lymph node (RPKM 11.3) and 10 other tissues See more Orthologs mouse all