LOXL2, Official Symbol LOXL2provided by HGNC Official Full Name lysyl oxidase like 2provided by HGNC Primary source HGNC:HGNC:6666 See related Ensembl:ENSG00000134013 MIM:606663; AllianceGenome:HGNC:6666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOR; LOR2; WS9-14 Summary This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 21.2), fat (RPKM 16.1) and 20 other tissues See more Orthologs all