MRAP2, Official Symbol MRAP2provided by HGNC Official Full Name melanocortin 2 receptor accessory protein 2provided by HGNC Primary source HGNC:HGNC:21232 See related Ensembl:ENSG00000135324 MIM:615410; AllianceGenome:HGNC:21232 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf117; bA51G5.2 Summary This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016] Expression Broad expression in brain (RPKM 4.0), adrenal (RPKM 2.1) and 20 other tissues See more Orthologs mouse all