TNFRSF14, Official Symbol TNFRSF14provided by HGNC Official Full Name TNF receptor superfamily member 14provided by HGNC Primary source HGNC:HGNC:11912 See related Ensembl:ENSG00000157873 MIM:602746; AllianceGenome:HGNC:11912 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TR2; ATAR; HVEA; HVEM; CD270; LIGHTR Summary This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues See more Orthologs mouse all