DNM1L, Official Symbol DNM1Lprovided by HGNC Official Full Name dynamin 1 likeprovided by HGNC Primary source HGNC:HGNC:2973 See related Ensembl:ENSG00000087470 MIM:603850; AllianceGenome:HGNC:2973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DLP1; DRP1; DVLP; EMPF; OPA5; EMPF1; DYMPLE; HDYNIV Summary This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 22.9) and 25 other tissues See more Orthologs mouse all