KCNE3, Official Symbol KCNE3provided by HGNC Official Full Name potassium voltage-gated channel subfamily E regulatory subunit 3provided by HGNC Primary source HGNC:HGNC:6243 See related Ensembl:ENSG00000175538 MIM:604433; AllianceGenome:HGNC:6243 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYPP; HOKPP; MiRP2; BRGDA6 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008] Expression Broad expression in duodenum (RPKM 10.8), stomach (RPKM 10.5) and 18 other tissues See more Orthologs mouse all