RIPK2, Official Symbol RIPK2provided by HGNC Official Full Name receptor interacting serine/threonine kinase 2provided by HGNC Primary source HGNC:HGNC:10020 See related Ensembl:ENSG00000104312 MIM:603455; AllianceGenome:HGNC:10020 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCK; RICK; RIP2; CARD3; GIG30; CARDIAK Summary This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 26.8), gall bladder (RPKM 8.2) and 24 other tissues See more Orthologs mouse all