CYP2C18, Official Symbol CYP2C18provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 18provided by HGNC Primary source HGNC:HGNC:2620 See related Ensembl:ENSG00000108242 MIM:601131; AllianceGenome:HGNC:2620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 50.3), duodenum (RPKM 49.6) and 5 other tissues See more Orthologs all