IRF1, Official Symbol IRF1provided by HGNC Official Full Name interferon regulatory factor 1provided by HGNC Primary source HGNC:HGNC:6116 See related Ensembl:ENSG00000125347 MIM:147575; AllianceGenome:HGNC:6116 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAR; IRF-1 Summary The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017] Expression Broad expression in bone marrow (RPKM 34.6), appendix (RPKM 32.5) and 24 other tissues See more Orthologs mouse all