POSTN, Official Symbol POSTNprovided by HGNC Official Full Name periostinprovided by HGNC Primary source HGNC:HGNC:16953 See related Ensembl:ENSG00000133110 MIM:608777; AllianceGenome:HGNC:16953 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PN; OSF2; OSF-2; PDLPOSTN Summary This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] Expression Broad expression in skin (RPKM 83.7), urinary bladder (RPKM 52.8) and 14 other tissues See more Orthologs mouse all