CPN1, Official Symbol CPN1provided by HGNC Official Full Name carboxypeptidase N subunit 1provided by HGNC Primary source HGNC:HGNC:2312 See related Ensembl:ENSG00000120054 MIM:603103; AllianceGenome:HGNC:2312 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPN; SCPN Summary Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 18.6) See more Orthologs mouse all