RNF6, Official Symbol RNF6provided by HGNC Official Full Name ring finger protein 6provided by HGNC Primary source HGNC:HGNC:10069 See related Ensembl:ENSG00000127870 MIM:604242; AllianceGenome:HGNC:10069 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.5), brain (RPKM 11.7) and 25 other tissues See more Orthologs mouse all