ADH1B, Official Symbol ADH1Bprovided by HGNC Official Full Name alcohol dehydrogenase 1B (class I), beta polypeptideprovided by HGNC Primary source HGNC:HGNC:250 See related Ensembl:ENSG00000196616 MIM:103720; AllianceGenome:HGNC:250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH2; HEL-S-117 Summary The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Biased expression in liver (RPKM 1714.7), fat (RPKM 1144.5) and 3 other tissues See more Orthologs all