SPARC, Official Symbol SPARCprovided by HGNC Official Full Name secreted protein acidic and cysteine richprovided by HGNC Primary source HGNC:HGNC:11219 See related Ensembl:ENSG00000113140 MIM:182120; AllianceGenome:HGNC:11219 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ON; ONT; OI17; BM-40 Summary This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015] Expression Broad expression in fat (RPKM 883.5), placenta (RPKM 823.4) and 20 other tissues See more Orthologs mouse all