PDPR, Official Symbol PDPRprovided by HGNC Official Full Name pyruvate dehydrogenase phosphatase regulatory subunitprovided by HGNC Primary source HGNC:HGNC:30264 See related Ensembl:ENSG00000090857 MIM:617835; AllianceGenome:HGNC:30264 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDP3 Summary Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in testis (RPKM 9.0), brain (RPKM 8.9) and 25 other tissues See more Orthologs mouse all