KRT2, Official Symbol KRT2provided by HGNC Official Full Name keratin 2provided by HGNC Primary source HGNC:HGNC:6439 See related Ensembl:ENSG00000172867 MIM:600194; AllianceGenome:HGNC:6439 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as K2e; KRTE; CK-2e; KRT2A; KRT2E Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] Expression Restricted expression toward skin (RPKM 1015.4) See more Orthologs mouse all