MSH4, Official Symbol MSH4provided by HGNC Official Full Name mutS homolog 4provided by HGNC Primary source HGNC:HGNC:7327 See related Ensembl:ENSG00000057468 MIM:602105; AllianceGenome:HGNC:7327 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASG; POF20; SPGF2 Summary This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011] Expression Biased expression in testis (RPKM 2.6) and small intestine (RPKM 0.1) See more Orthologs mouse all