DROSHA, Official Symbol DROSHAprovided by HGNC Official Full Name drosha ribonuclease IIIprovided by HGNC Primary source HGNC:HGNC:17904 See related Ensembl:ENSG00000113360 MIM:608828; AllianceGenome:HGNC:17904 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976 Summary This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 9.5), ovary (RPKM 7.6) and 25 other tissues See more Orthologs mouse all