LPL, Official Symbol LPLprovided by HGNC Official Full Name lipoprotein lipaseprovided by HGNC Primary source HGNC:HGNC:6677 See related Ensembl:ENSG00000175445 MIM:609708; AllianceGenome:HGNC:6677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIPD; HDLCQ11 Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 753.5) and heart (RPKM 154.2) See more Orthologs mouse all