SP140, Official Symbol SP140provided by HGNC Official Full Name SP140 nuclear body proteinprovided by HGNC Primary source HGNC:HGNC:17133 See related Ensembl:ENSG00000079263 MIM:608602; AllianceGenome:HGNC:17133 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYSP100; LYSP100-A; LYSP100-B Summary This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016] Expression Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues See more Orthologs all