LSM1, Official Symbol LSM1provided by HGNC Official Full Name LSM1 homolog, mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:20472 See related Ensembl:ENSG00000175324 MIM:607281; AllianceGenome:HGNC:20472 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CASM; YJL124C Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in heart (RPKM 16.1), placenta (RPKM 14.6) and 25 other tissues See more Orthologs mouse all