PGAP1, Official Symbol PGAP1provided by HGNC Official Full Name post-GPI attachment to proteins inositol deacylase 1provided by HGNC Primary source HGNC:HGNC:25712 See related Ensembl:ENSG00000197121 MIM:611655; AllianceGenome:HGNC:25712 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Bst1; MRT42; SPG67; NEDDSBA; ISPD3024 Summary The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause an autosomal recessive form of cognitive impairment. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in adrenal (RPKM 6.0), brain (RPKM 5.4) and 24 other tissues See more Orthologs mouse all