PIDD1, Official Symbol PIDD1provided by HGNC Official Full Name p53-induced death domain protein 1provided by HGNC Primary source HGNC:HGNC:16491 See related Ensembl:ENSG00000177595 MIM:605247; AllianceGenome:HGNC:16491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRDD; PIDD; MRT75 Summary The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 3.7), spleen (RPKM 3.6) and 25 other tissues See more Orthologs mouse all