HEY2, Official Symbol HEY2provided by HGNC Official Full Name hes related family bHLH transcription factor with YRPW motif 2provided by HGNC Primary source HGNC:HGNC:4881 See related Ensembl:ENSG00000135547 MIM:604674; AllianceGenome:HGNC:4881 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRL; CHF1; HRT2; HERP1; HESR2; bHLHb32; GRIDLOCK Summary This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 2.9), brain (RPKM 2.7) and 22 other tissues See more Orthologs mouse all