CMTM8, Official Symbol CMTM8provided by HGNC Official Full Name CKLF like MARVEL transmembrane domain containing 8provided by HGNC Primary source HGNC:HGNC:19179 See related Ensembl:ENSG00000170293 MIM:607891; AllianceGenome:HGNC:19179 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKLFSF8; CKLFSF8-V2 Summary This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] Expression Broad expression in liver (RPKM 5.0), lung (RPKM 5.0) and 23 other tissues See more Orthologs mouse all