ANAPC10, Official Symbol ANAPC10provided by HGNC Official Full Name anaphase promoting complex subunit 10provided by HGNC Primary source HGNC:HGNC:24077 See related Ensembl:ENSG00000164162 MIM:613745; AllianceGenome:HGNC:24077 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOC1; APC10 Summary ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011] Expression Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues See more Orthologs mouse all