NEO1, Official Symbol NEO1provided by HGNC Official Full Name neogenin 1provided by HGNC Primary source HGNC:HGNC:7754 See related Ensembl:ENSG00000067141 MIM:601907; AllianceGenome:HGNC:7754 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NGN; IGDCC2; NTN1R2 Summary This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] Expression Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues See more Orthologs mouse all