TSN, Official Symbol TSNprovided by HGNC Official Full Name translinprovided by HGNC Primary source HGNC:HGNC:12379 See related Ensembl:ENSG00000211460 MIM:600575; AllianceGenome:HGNC:12379 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1 Summary This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] Expression Ubiquitous expression in testis (RPKM 26.5), brain (RPKM 20.8) and 25 other tissues See more Orthologs mouse all