TLE4, Official Symbol TLE4provided by HGNC Official Full Name TLE family member 4, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11840 See related Ensembl:ENSG00000106829 MIM:605132; AllianceGenome:HGNC:11840 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl) Summary Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more Orthologs mouse all