CLCNKB, Official Symbol CLCNKBprovided by HGNC Official Full Name chloride voltage-gated channel Kbprovided by HGNC Primary source HGNC:HGNC:2027 See related Ensembl:ENSG00000184908 MIM:602023; AllianceGenome:HGNC:2027 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLCKB; ClC-K2; ClC-Kb Summary The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Biased expression in kidney (RPKM 65.3), salivary gland (RPKM 9.9) and 1 other tissue See more Orthologs all