ADGRE2, Official Symbol ADGRE2provided by HGNC Official Full Name adhesion G protein-coupled receptor E2provided by HGNC Primary source HGNC:HGNC:3337 See related Ensembl:ENSG00000127507 MIM:606100; AllianceGenome:HGNC:3337 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VBU; CD97; EMR2; CD312 Summary This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] Expression Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more Orthologs all