PIK3R1, Official Symbol PIK3R1provided by HGNC Official Full Name phosphoinositide-3-kinase regulatory subunit 1provided by HGNC Primary source HGNC:HGNC:8979 See related Ensembl:ENSG00000145675 MIM:171833; AllianceGenome:HGNC:8979 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p85; AGM7; GRB1; IMD36; p85alpha; p85-ALPHA Summary Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] Expression Ubiquitous expression in fat (RPKM 16.6), brain (RPKM 16.6) and 24 other tissues See more Orthologs mouse all