SPTBN1, Official Symbol SPTBN1provided by HGNC Official Full Name spectrin beta, non-erythrocytic 1provided by HGNC Primary source HGNC:HGNC:11275 See related Ensembl:ENSG00000115306 MIM:182790; AllianceGenome:HGNC:11275 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ELF; SPTB2; DDISBA; HEL102; betaSpII Summary Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 102.5), lung (RPKM 72.2) and 24 other tissues See more Orthologs mouse all