RING1, Official Symbol RING1provided by HGNC Official Full Name ring finger protein 1provided by HGNC Primary source HGNC:HGNC:10018 See related Ensembl:ENSG00000204227 MIM:602045; AllianceGenome:HGNC:10018 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF1; RING1A Summary This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 22.9), ovary (RPKM 22.0) and 25 other tissues See more Orthologs mouse all