RHEB, Official Symbol RHEBprovided by HGNC Official Full Name Ras homolog, mTORC1 bindingprovided by HGNC Primary source HGNC:HGNC:10011 See related Ensembl:ENSG00000106615 MIM:601293; AllianceGenome:HGNC:10011 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHEB2 Summary This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 38.1), brain (RPKM 36.3) and 25 other tissues See more Orthologs mouse all