TNFRSF10B, Official Symbol TNFRSF10Bprovided by HGNC Official Full Name TNF receptor superfamily member 10bprovided by HGNC Primary source HGNC:HGNC:11905 See related Ensembl:ENSG00000120889 MIM:603612; AllianceGenome:HGNC:11905 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in gall bladder (RPKM 17.8), urinary bladder (RPKM 14.8) and 25 other tissues See more Orthologs mouse all