IL23A, Official Symbol IL23Aprovided by HGNC Official Full Name interleukin 23 subunit alphaprovided by HGNC Primary source HGNC:HGNC:15488 See related Ensembl:ENSG00000110944 MIM:605580; AllianceGenome:HGNC:15488 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P19; SGRF; IL-23; IL-23A; IL23P19 Summary This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues See more Orthologs mouse all