DPH7, Official Symbol DPH7provided by HGNC Official Full Name diphthamide biosynthesis 7provided by HGNC Primary source HGNC:HGNC:25199 See related Ensembl:ENSG00000148399 MIM:613210; AllianceGenome:HGNC:25199 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRT2; WDR85; C9orf112 Summary Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016] Expression Ubiquitous expression in testis (RPKM 4.1), spleen (RPKM 3.9) and 25 other tissues See more Orthologs mouse all