ACVR1C, Official Symbol ACVR1Cprovided by HGNC Official Full Name activin A receptor type 1Cprovided by HGNC Primary source HGNC:HGNC:18123 See related Ensembl:ENSG00000123612 MIM:608981; AllianceGenome:HGNC:18123 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALK7; ACVRLK7 Summary ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] Expression Biased expression in fat (RPKM 19.0), colon (RPKM 1.8) and 6 other tissues See more Orthologs mouse all