RNASEL, Official Symbol RNASELprovided by HGNC Official Full Name ribonuclease Lprovided by HGNC Primary source HGNC:HGNC:10050 See related Ensembl:ENSG00000135828 MIM:180435; AllianceGenome:HGNC:10050 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNS4; PRCA1 Summary This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in thyroid (RPKM 5.0), ovary (RPKM 4.7) and 25 other tissues See more Orthologs mouse all