CDC6, Official Symbol CDC6provided by HGNC Official Full Name cell division cycle 6provided by HGNC Primary source HGNC:HGNC:1744 See related Ensembl:ENSG00000094804 MIM:602627; AllianceGenome:HGNC:1744 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC18L; HsCDC6; MGORS5; HsCDC18 Summary The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues See more Orthologs mouse all