CD1A, Official Symbol CD1Aprovided by HGNC Official Full Name CD1a moleculeprovided by HGNC Primary source HGNC:HGNC:1634 See related Ensembl:ENSG00000158477 MIM:188370; AllianceGenome:HGNC:1634 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R4; T6; CD1; FCB6; HTA1 Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Biased expression in skin (RPKM 10.0), esophagus (RPKM 4.8) and 4 other tissues See more Orthologs all