SUN2, Official Symbol SUN2provided by HGNC Official Full Name Sad1 and UNC84 domain containing 2provided by HGNC Primary source HGNC:HGNC:14210 See related Ensembl:ENSG00000100242 MIM:613569; AllianceGenome:HGNC:14210 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC84B; rab5IP Summary SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in fat (RPKM 47.2), bone marrow (RPKM 33.2) and 25 other tissues See more Orthologs mouse all