DOT1L, Official Symbol DOT1Lprovided by HGNC Official Full Name DOT1 like histone lysine methyltransferaseprovided by HGNC Primary source HGNC:HGNC:24948 See related Ensembl:ENSG00000104885 MIM:607375; AllianceGenome:HGNC:24948 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOT1; KMT4 Summary The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 18.3), bone marrow (RPKM 5.1) and 22 other tissues See more Orthologs mouse all