ZAP70, Official Symbol ZAP70provided by HGNC Official Full Name zeta chain of T cell receptor associated protein kinase 70provided by HGNC Primary source HGNC:HGNC:12858 See related Ensembl:ENSG00000115085 MIM:176947; AllianceGenome:HGNC:12858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70 Summary This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 11.2), spleen (RPKM 7.9) and 11 other tissues See more Orthologs mouse all