HEXIM2, Official Symbol HEXIM2provided by HGNC Official Full Name HEXIM P-TEFb complex subunit 2provided by HGNC Primary source HGNC:HGNC:28591 See related Ensembl:ENSG00000168517 MIM:615695; AllianceGenome:HGNC:28591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L3 Summary This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Broad expression in testis (RPKM 8.0), kidney (RPKM 3.7) and 25 other tissues See more Orthologs mouse all