DR1, Official Symbol DR1provided by HGNC Official Full Name down-regulator of transcription 1provided by HGNC Primary source HGNC:HGNC:3017 See related Ensembl:ENSG00000117505 MIM:601482; AllianceGenome:HGNC:3017 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NC2; NC2B; NCB2; NC2-BETA Summary This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 31.0), lymph node (RPKM 21.9) and 25 other tissues See more Orthologs mouse all