APOBEC3A, Official Symbol APOBEC3Aprovided by HGNC Official Full Name apolipoprotein B mRNA editing enzyme catalytic subunit 3Aprovided by HGNC Primary source HGNC:HGNC:17343 See related Ensembl:ENSG00000128383 MIM:607109; AllianceGenome:HGNC:17343 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A3A; ARP3; PHRBN; bK150C2.1 Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] Expression Biased expression in bone marrow (RPKM 38.8), appendix (RPKM 13.8) and 5 other tissues See more Orthologs all