PDE1A, Official Symbol PDE1Aprovided by HGNC Official Full Name phosphodiesterase 1Aprovided by HGNC Primary source HGNC:HGNC:8774 See related Ensembl:ENSG00000115252 MIM:171890; AllianceGenome:HGNC:8774 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A Summary Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] Expression Broad expression in thyroid (RPKM 7.4), brain (RPKM 6.5) and 18 other tissues See more Orthologs mouse all