LPXN, Official Symbol LPXNprovided by HGNC Official Full Name leupaxinprovided by HGNC Primary source HGNC:HGNC:14061 See related Ensembl:ENSG00000110031 MIM:605390; AllianceGenome:HGNC:14061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LDPL Summary The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] Expression Broad expression in lymph node (RPKM 15.3), appendix (RPKM 9.9) and 22 other tissues See more Orthologs mouse all