IL24, Official Symbol IL24provided by HGNC Official Full Name interleukin 24provided by HGNC Primary source HGNC:HGNC:11346 See related Ensembl:ENSG00000162892 MIM:604136; AllianceGenome:HGNC:11346 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C49A; FISP; MDA7; MOB5; ST16; IL10B Summary This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 12.3), spleen (RPKM 9.6) and 6 other tissues See more Orthologs mouse all