TPH1, Official Symbol TPH1provided by HGNC Official Full Name tryptophan hydroxylase 1provided by HGNC Primary source HGNC:HGNC:12008 See related Ensembl:ENSG00000129167 MIM:191060; AllianceGenome:HGNC:12008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRH; TRPH Summary This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009] Expression Biased expression in stomach (RPKM 7.1), colon (RPKM 5.4) and 7 other tissues See more Orthologs mouse all