DCN, Official Symbol DCNprovided by HGNC Official Full Name decorinprovided by HGNC Primary source HGNC:HGNC:2705 See related Ensembl:ENSG00000011465 MIM:125255; AllianceGenome:HGNC:2705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B Summary This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015] Expression Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more Orthologs mouse all