P2RX7, Official Symbol P2RX7provided by HGNC Official Full Name purinergic receptor P2X 7provided by HGNC Primary source HGNC:HGNC:8537 See related Ensembl:ENSG00000089041 MIM:602566; AllianceGenome:HGNC:8537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X7 Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] Expression Broad expression in brain (RPKM 6.8), skin (RPKM 4.9) and 23 other tissues See more Orthologs mouse all