ASPM, Official Symbol ASPMprovided by HGNC Official Full Name assembly factor for spindle microtubulesprovided by HGNC Primary source HGNC:HGNC:19048 See related Ensembl:ENSG00000066279 MIM:605481; AllianceGenome:HGNC:19048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASP; MCPH5; Calmbp1 Summary This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] Expression Broad expression in bone marrow (RPKM 4.7), lymph node (RPKM 3.5) and 14 other tissues See more Orthologs mouse all