ELF5, Official Symbol ELF5provided by HGNC Official Full Name E74 like ETS transcription factor 5provided by HGNC Primary source HGNC:HGNC:3320 See related Ensembl:ENSG00000135374 MIM:605169; AllianceGenome:HGNC:3320 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESE2 Summary This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast cancer. [provided by RefSeq, May 2022] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Biased expression in salivary gland (RPKM 27.3), kidney (RPKM 9.7) and 2 other tissues See more Orthologs mouse all