SOSTDC1, Official Symbol SOSTDC1provided by HGNC Official Full Name sclerostin domain containing 1provided by HGNC Primary source HGNC:HGNC:21748 See related Ensembl:ENSG00000171243 MIM:609675; AllianceGenome:HGNC:21748 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAND7; USAG1; CDA019; ECTODIN Summary This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 31.5), stomach (RPKM 24.1) and 9 other tissues See more Orthologs mouse all