TLR8, Official Symbol TLR8provided by HGNC Official Full Name toll like receptor 8provided by HGNC Primary source HGNC:HGNC:15632 See related Ensembl:ENSG00000101916 MIM:300366; AllianceGenome:HGNC:15632 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD288; IMD98; TLR-8; hTLR8 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 9 other tissues See more Orthologs mouse all