IL27RA, Official Symbol IL27RAprovided by HGNC Official Full Name interleukin 27 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:17290 See related Ensembl:ENSG00000104998 MIM:605350; AllianceGenome:HGNC:17290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1 Summary In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 12.2), appendix (RPKM 9.7) and 22 other tissues See more Orthologs mouse all