MYL12A, Official Symbol MYL12Aprovided by HGNC Official Full Name myosin light chain 12Aprovided by HGNC Primary source HGNC:HGNC:16701 See related Ensembl:ENSG00000101608 AllianceGenome:HGNC:16701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24 Summary This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014] Expression Broad expression in heart (RPKM 774.2), lung (RPKM 179.0) and 22 other tissues See more Orthologs all