ARHGEF25, Official Symbol ARHGEF25provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 25provided by HGNC Primary source HGNC:HGNC:30275 See related Ensembl:ENSG00000240771 MIM:610215; AllianceGenome:HGNC:30275 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GEFT; p63RhoGEF Summary Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in endometrium (RPKM 29.1), prostate (RPKM 19.9) and 22 other tissues See more Orthologs mouse all