CABLES1, Official Symbol CABLES1provided by HGNC Official Full Name Cdk5 and Abl enzyme substrate 1provided by HGNC Primary source HGNC:HGNC:25097 See related Ensembl:ENSG00000134508 MIM:609194; AllianceGenome:HGNC:25097 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CABL1; IK3-1; CABLES; HsT2563 Summary This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in lung (RPKM 9.3), fat (RPKM 7.7) and 24 other tissues See more Orthologs mouse all