GSTZ1, Official Symbol GSTZ1provided by HGNC Official Full Name glutathione S-transferase zeta 1provided by HGNC Primary source HGNC:HGNC:4643 See related Ensembl:ENSG00000100577 MIM:603758; AllianceGenome:HGNC:4643 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAI; MAAI; MAAID; GSTZ1-1 Summary This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015] Expression Broad expression in liver (RPKM 23.8), testis (RPKM 10.9) and 24 other tissues See more Orthologs mouse all