AP1S3, Official Symbol AP1S3provided by HGNC Official Full Name adaptor related protein complex 1 subunit sigma 3provided by HGNC Primary source HGNC:HGNC:18971 See related Ensembl:ENSG00000152056 MIM:615781; AllianceGenome:HGNC:18971 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSORS15; sigma1C Summary This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Broad expression in thyroid (RPKM 6.9), stomach (RPKM 3.1) and 16 other tissues See more Orthologs mouse all