FLG2, Official Symbol FLG2provided by HGNC Official Full Name filaggrin 2provided by HGNC Primary source HGNC:HGNC:33276 See related Ensembl:ENSG00000143520 MIM:616284; AllianceGenome:HGNC:33276 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFPS; PSS6 Summary The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli. [provided by RefSeq, Jul 2020] Expression Restricted expression toward skin (RPKM 248.2) See more Orthologs all