NRG2, Official Symbol NRG2provided by HGNC Official Full Name neuregulin 2provided by HGNC Primary source HGNC:HGNC:7998 See related Ensembl:ENSG00000158458 MIM:603818; AllianceGenome:HGNC:7998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DON1; HRG2; NTAK Summary This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010] Expression Broad expression in ovary (RPKM 1.6), fat (RPKM 0.8) and 16 other tissues See more Orthologs mouse all