ARHGEF10, Official Symbol ARHGEF10provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 10provided by HGNC Primary source HGNC:HGNC:14103 See related Ensembl:ENSG00000104728 MIM:608136; AllianceGenome:HGNC:14103 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNCV; GEF10 Summary This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Broad expression in testis (RPKM 15.4), lung (RPKM 12.1) and 22 other tissues See more Orthologs mouse all