RACGAP1, Official Symbol RACGAP1provided by HGNC Official Full Name Rac GTPase activating protein 1provided by HGNC Primary source HGNC:HGNC:9804 See related Ensembl:ENSG00000161800 MIM:604980; AllianceGenome:HGNC:9804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYK4; CDAN3B; ID-GAP; HsCYK-4; MgcRacGAP Summary This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016] Expression Broad expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 20 other tissues See more Orthologs mouse all