ACTR1B, Official Symbol ACTR1Bprovided by HGNC Official Full Name actin related protein 1Bprovided by HGNC Primary source HGNC:HGNC:168 See related Ensembl:ENSG00000115073 MIM:605144; AllianceGenome:HGNC:168 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PC3; ARP1B; CTRN2 Summary This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in spleen (RPKM 24.2), brain (RPKM 24.1) and 25 other tissues See more Orthologs mouse all