TMC6, Official Symbol TMC6provided by HGNC Official Full Name transmembrane channel like 6provided by HGNC Primary source HGNC:HGNC:18021 See related Ensembl:ENSG00000141524 MIM:605828; AllianceGenome:HGNC:18021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EV1; lnc; EVER1; EVIN1; LAK-4P; TNRC6C-AS1 Summary Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 21.6), lymph node (RPKM 18.5) and 20 other tissues See more Orthologs mouse all