GUCA2B, Official Symbol GUCA2Bprovided by HGNC Official Full Name guanylate cyclase activator 2Bprovided by HGNC Primary source HGNC:HGNC:4683 See related Ensembl:ENSG00000044012 MIM:601271; AllianceGenome:HGNC:4683 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UGN; GCAP-II Summary This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015] Expression Biased expression in small intestine (RPKM 47.4), colon (RPKM 37.0) and 1 other tissue See more Orthologs mouse all