ANKLE1, Official Symbol ANKLE1provided by HGNC Official Full Name ankyrin repeat and LEM domain containing 1provided by HGNC Primary source HGNC:HGNC:26812 See related Ensembl:ENSG00000160117 MIM:619348; AllianceGenome:HGNC:26812 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEM3; LEMD6; ANKRD41 Summary Enables endonuclease activity. Involved in positive regulation of response to DNA damage stimulus and protein export from nucleus. Located in cytosol and nucleoplasm. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 8.2), lymph node (RPKM 1.3) and 2 other tissues See more Orthologs mouse all