SLC11A1, Official Symbol SLC11A1provided by HGNC Official Full Name solute carrier family 11 member 1provided by HGNC Primary source HGNC:HGNC:10907 See related Ensembl:ENSG00000018280 MIM:600266; AllianceGenome:HGNC:10907 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSH; NRAMP; NRAMP1 Summary This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 10.4), appendix (RPKM 8.8) and 7 other tissues See more Orthologs mouse all