KALRN, Official Symbol KALRNprovided by HGNC Official Full Name kalirin RhoGEF kinaseprovided by HGNC Primary source HGNC:HGNC:4814 See related Ensembl:ENSG00000160145 MIM:604605; AllianceGenome:HGNC:4814 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; KALNC2; ARHGEF24 Summary Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016] Expression Broad expression in brain (RPKM 3.5), small intestine (RPKM 1.5) and 20 other tissues See more Orthologs mouse all