GALNT8, Official Symbol GALNT8provided by HGNC Official Full Name polypeptide N-acetylgalactosaminyltransferase 8provided by HGNC Primary source HGNC:HGNC:4130 See related Ensembl:ENSG00000130035 MIM:606250; AllianceGenome:HGNC:4130 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GALNAC-T8 Summary This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 8.3), small intestine (RPKM 6.0) and 3 other tissues See more Orthologs mouse all