CCNDBP1, Official Symbol CCNDBP1provided by HGNC Official Full Name cyclin D1 binding protein 1provided by HGNC Primary source HGNC:HGNC:1587 See related Ensembl:ENSG00000166946 MIM:607089; AllianceGenome:HGNC:1587 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHM; DIP1; GCIP Summary This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009] Expression Ubiquitous expression in bone marrow (RPKM 23.1), placenta (RPKM 18.5) and 25 other tissues See more Orthologs mouse all