MECOM, Official Symbol MECOMprovided by HGNC Official Full Name MDS1 and EVI1 complex locusprovided by HGNC Primary source HGNC:HGNC:3498 See related Ensembl:ENSG00000085276 MIM:165215; AllianceGenome:HGNC:3498 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EVI1; MDS1; KMT8E; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1 Summary The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Expression Broad expression in stomach (RPKM 15.9), kidney (RPKM 12.6) and 18 other tissues See more Orthologs mouse all