HDGFL2, Official Symbol HDGFL2provided by HGNC Official Full Name HDGF like 2provided by HGNC Primary source HGNC:HGNC:14680 See related Ensembl:ENSG00000167674 MIM:617884; AllianceGenome:HGNC:14680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRP2; HDGF2; HRP-2; HDGF-2; HDGFRP2 Summary This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in testis (RPKM 20.4), brain (RPKM 10.1) and 25 other tissues See more Orthologs mouse all