ARAF, Official Symbol ARAFprovided by HGNC Official Full Name A-Raf proto-oncogene, serine/threonine kinaseprovided by HGNC Primary source HGNC:HGNC:646 See related Ensembl:ENSG00000078061 MIM:311010; AllianceGenome:HGNC:646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKS2; A-RAF; ARAF1; RAFA1 Summary Enables protein serine/threonine kinase activity. Involved in negative regulation of apoptotic process; regulation of TOR signaling; and regulation of cellular protein metabolic process. Predicted to be active in cytosol and mitochondrion. Biomarker of high grade glioma. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 16.5), spleen (RPKM 14.0) and 25 other tissues See more Orthologs mouse all