PRKAG2, Official Symbol PRKAG2provided by HGNC Official Full Name protein kinase AMP-activated non-catalytic subunit gamma 2provided by HGNC Primary source HGNC:HGNC:9386 See related Ensembl:ENSG00000106617 MIM:602743; AllianceGenome:HGNC:9386 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAKG; CMH6; WPWS; AAKG2; H91620p Summary AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in heart (RPKM 15.2), prostate (RPKM 4.8) and 24 other tissues See more Orthologs mouse all