PARP3, Official Symbol PARP3provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 3provided by HGNC Primary source HGNC:HGNC:273 See related Ensembl:ENSG00000041880 MIM:607726; AllianceGenome:HGNC:273 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3 Summary The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues See more Orthologs mouse all