KCNMB4, Official Symbol KCNMB4provided by HGNC Official Full Name potassium calcium-activated channel subfamily M regulatory beta subunit 4provided by HGNC Primary source HGNC:HGNC:6289 See related Ensembl:ENSG00000135643 MIM:605223; AllianceGenome:HGNC:6289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 7.6), adrenal (RPKM 4.7) and 15 other tissues See more Orthologs mouse all