KIRREL3, Official Symbol KIRREL3provided by HGNC Official Full Name kirre like nephrin family adhesion molecule 3provided by HGNC Primary source HGNC:HGNC:23204 See related Ensembl:ENSG00000149571 MIM:607761; AllianceGenome:HGNC:23204 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRD4; KIRRE; NEPH2; PRO4502 Summary The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017] Expression Biased expression in brain (RPKM 6.0), adrenal (RPKM 0.5) and 1 other tissue See more Orthologs mouse all