SLAMF6, Official Symbol SLAMF6provided by HGNC Official Full Name SLAM family member 6provided by HGNC Primary source HGNC:HGNC:21392 See related Ensembl:ENSG00000162739 MIM:606446; AllianceGenome:HGNC:21392 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000 Summary The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] Expression Biased expression in lymph node (RPKM 29.2), spleen (RPKM 15.5) and 7 other tissues See more Orthologs mouse all