DUOX2, Official Symbol DUOX2provided by HGNC Official Full Name dual oxidase 2provided by HGNC Primary source HGNC:HGNC:13273 See related Ensembl:ENSG00000140279 MIM:606759; AllianceGenome:HGNC:13273 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TDH6; LNOX2; THOX2; NOXEF2; P138-TOX Summary The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008] Expression Biased expression in gall bladder (RPKM 216.4), thyroid (RPKM 55.7) and 3 other tissues See more Orthologs mouse all