SFRP5, Official Symbol SFRP5provided by HGNC Official Full Name secreted frizzled related protein 5provided by HGNC Primary source HGNC:HGNC:10779 See related Ensembl:ENSG00000120057 MIM:604158; AllianceGenome:HGNC:10779 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SARP3 Summary Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008] Expression Biased expression in pancreas (RPKM 17.7), duodenum (RPKM 13.1) and 9 other tissues See more Orthologs mouse all