KNDC1, Official Symbol KNDC1provided by HGNC Official Full Name kinase non-catalytic C-lobe domain containing 1provided by HGNC Primary source HGNC:HGNC:29374 See related Ensembl:ENSG00000171798 MIM:616237; AllianceGenome:HGNC:29374 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as v-KIND; RASGEF2; C10orf23; Very-KIND; bB439H18.3 Summary The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016] Expression Biased expression in brain (RPKM 6.5), ovary (RPKM 2.2) and 6 other tissues See more Orthologs mouse all