DIS3, Official Symbol DIS3provided by HGNC Official Full Name DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by HGNC Primary source HGNC:HGNC:20604 See related Ensembl:ENSG00000083520 MIM:607533; AllianceGenome:HGNC:20604 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik Summary Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues See more Orthologs mouse all