ITIH2, Official Symbol ITIH2provided by HGNC Official Full Name inter-alpha-trypsin inhibitor heavy chain 2provided by HGNC Primary source HGNC:HGNC:6167 See related Ensembl:ENSG00000151655 MIM:146640; AllianceGenome:HGNC:6167 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H2P; SHAP; ITI-HC2 Summary The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009] Expression Restricted expression toward liver (RPKM 486.6) See more Orthologs mouse all