FADS1, Official Symbol FADS1provided by HGNC Official Full Name fatty acid desaturase 1provided by HGNC Primary source HGNC:HGNC:3574 See related Ensembl:ENSG00000149485 MIM:606148; AllianceGenome:HGNC:3574 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D5D; TU12; FADS6; FADSD5; LLCDL1 Summary The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 31.8), brain (RPKM 28.7) and 20 other tissues See more Orthologs mouse all