KDM4E, Official Symbol KDM4Eprovided by HGNC Official Full Name lysine demethylase 4Eprovided by HGNC Primary source HGNC:HGNC:37098 See related Ensembl:ENSG00000235268 MIM:616581; AllianceGenome:HGNC:37098 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KDM5E; JMJD2E; KDM4DL Summary The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016] Orthologs all