GPX5, Official Symbol GPX5provided by HGNC Official Full Name glutathione peroxidase 5provided by HGNC Primary source HGNC:HGNC:4557 See related Ensembl:ENSG00000224586 MIM:603435; AllianceGenome:HGNC:4557 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGLP; GPx-5; GSHPx-5; HEL-S-75p Summary This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016] Expression Restricted expression toward testis (RPKM 1.2) See more Orthologs mouse all