RBBP6, Official Symbol RBBP6provided by HGNC Official Full Name RB binding protein 6, ubiquitin ligaseprovided by HGNC Primary source HGNC:HGNC:9889 See related Ensembl:ENSG00000122257 MIM:600938; AllianceGenome:HGNC:9889 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PACT; MY038; P2P-R; RBQ-1; SNAMA Summary The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 15.6), testis (RPKM 14.0) and 25 other tissues See more Orthologs mouse all