CD27, Official Symbol CD27provided by HGNC Official Full Name CD27 moleculeprovided by HGNC Primary source HGNC:HGNC:11922 See related Ensembl:ENSG00000139193 MIM:186711; AllianceGenome:HGNC:11922 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T14; S152; Tp55; TNFRSF7; S152. LPFS2 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 38.5), spleen (RPKM 21.6) and 14 other tissues See more Orthologs mouse all