KLF8, Official Symbol KLF8provided by HGNC Official Full Name KLF transcription factor 8provided by HGNC Primary source HGNC:HGNC:6351 See related Ensembl:ENSG00000102349 MIM:300286; AllianceGenome:HGNC:6351 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BKLF3; ZNF741 Summary This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] Expression Broad expression in skin (RPKM 8.2), fat (RPKM 3.4) and 20 other tissues See more Orthologs mouse all