HOTAIR, Official Symbol HOTAIRprovided by HGNC Official Full Name HOX transcript antisense RNAprovided by HGNC Primary source HGNC:HGNC:33510 See related Ensembl:ENSG00000228630 MIM:611400; AllianceGenome:HGNC:33510 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 Summary This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019] Expression Biased expression in testis (RPKM 1.6), skin (RPKM 1.2) and 6 other tissues See more Orthologs mouse all