SORL1, Official Symbol SORL1provided by HGNC Official Full Name sortilin related receptor 1provided by HGNC Primary source HGNC:HGNC:11185 See related Ensembl:ENSG00000137642 MIM:602005; AllianceGenome:HGNC:11185 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32 Summary This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016] Annotation information Note: In some of the published literature, this gene has been incorrectly associated with the LRP9 alias, but the LRP9 alias more correctly refers to Gene ID 26020, LRP10. [05 May 2010] Expression Ubiquitous expression in brain (RPKM 22.4), liver (RPKM 16.3) and 21 other tissues See more Orthologs mouse all