LILRB2, Official Symbol LILRB2provided by HGNC Official Full Name leukocyte immunoglobulin like receptor B2provided by HGNC Primary source HGNC:HGNC:6606 See related Ensembl:ENSG00000131042 MIM:604815; AllianceGenome:HGNC:6606 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10 Summary This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 54.6), bone marrow (RPKM 26.2) and 5 other tissues See more Orthologs all