RBFOX3, Official Symbol RBFOX3provided by HGNC Official Full Name RNA binding fox-1 homolog 3provided by HGNC Primary source HGNC:HGNC:27097 See related Ensembl:ENSG00000167281 MIM:616999; AllianceGenome:HGNC:27097 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOX3; NEUN; FOX-3; HRNBP3 Summary This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017] Expression Biased expression in brain (RPKM 11.3), prostate (RPKM 4.9) and 4 other tissues See more Orthologs mouse all