USP5, Official Symbol USP5provided by HGNC Official Full Name ubiquitin specific peptidase 5provided by HGNC Primary source HGNC:HGNC:12628 See related Ensembl:ENSG00000111667 MIM:601447; AllianceGenome:HGNC:12628 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ISOT Summary Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in testis (RPKM 36.2), brain (RPKM 33.4) and 25 other tissues See more Orthologs mouse all