MED25, Official Symbol MED25provided by HGNC Official Full Name mediator complex subunit 25provided by HGNC Primary source HGNC:HGNC:28845 See related Ensembl:ENSG00000104973 MIM:610197; AllianceGenome:HGNC:28845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758 Summary This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010] Expression Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues See more Orthologs mouse all