FGD2, Official Symbol FGD2provided by HGNC Official Full Name FYVE, RhoGEF and PH domain containing 2provided by HGNC Primary source HGNC:HGNC:3664 See related Ensembl:ENSG00000146192 MIM:605091; AllianceGenome:HGNC:3664 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFYVE4 Summary The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016] Expression Biased expression in spleen (RPKM 19.9), lymph node (RPKM 9.1) and 13 other tissues See more Orthologs mouse all