XRCC1, Official Symbol XRCC1provided by HGNC Official Full Name X-ray repair cross complementing 1provided by HGNC Primary source HGNC:HGNC:12828 See related Ensembl:ENSG00000073050 MIM:194360; AllianceGenome:HGNC:12828 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCC; SCAR26 Summary The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 16.0), testis (RPKM 12.7) and 25 other tissues See more Orthologs mouse all