LZTS2, Official Symbol LZTS2provided by HGNC Official Full Name leucine zipper tumor suppressor 2provided by HGNC Primary source HGNC:HGNC:29381 See related Ensembl:ENSG00000107816 MIM:610454; AllianceGenome:HGNC:29381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAPSER1 Summary The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in endometrium (RPKM 12.4), fat (RPKM 11.4) and 25 other tissues See more Orthologs mouse all