ARHGAP4, Official Symbol ARHGAP4provided by HGNC Official Full Name Rho GTPase activating protein 4provided by HGNC Primary source HGNC:HGNC:674 See related Ensembl:ENSG00000089820 MIM:300023; AllianceGenome:HGNC:674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1; RGC1; p115; SrGAP4; RhoGAP4 Summary This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Broad expression in spleen (RPKM 47.8), bone marrow (RPKM 45.7) and 16 other tissues See more Orthologs mouse all