ALPI, Official Symbol ALPIprovided by HGNC Official Full Name alkaline phosphatase, intestinalprovided by HGNC Primary source HGNC:HGNC:437 See related Ensembl:ENSG00000163295 MIM:171740; AllianceGenome:HGNC:437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IAP Summary There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014] Expression Biased expression in duodenum (RPKM 85.5), small intestine (RPKM 83.4) and 1 other tissue See more Orthologs mouse all