PARL, Official Symbol PARLprovided by HGNC Official Full Name presenilin associated rhomboid likeprovided by HGNC Primary source HGNC:HGNC:18253 See related Ensembl:ENSG00000175193 MIM:607858; AllianceGenome:HGNC:18253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2 Summary This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016] Expression Ubiquitous expression in fat (RPKM 16.5), colon (RPKM 14.6) and 25 other tissues See more Orthologs mouse all