CYP2C9, Official Symbol CYP2C9provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 9provided by HGNC Primary source HGNC:HGNC:2623 See related Ensembl:ENSG00000138109 MIM:601130; AllianceGenome:HGNC:2623 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9; P450IIC9 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 331.8), duodenum (RPKM 60.3) and 1 other tissue See more Orthologs all