PPHLN1, Official Symbol PPHLN1provided by HGNC Official Full Name periphilin 1provided by HGNC Primary source HGNC:HGNC:19369 See related Ensembl:ENSG00000134283 MIM:608150; AllianceGenome:HGNC:19369 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR; HSPC206; HSPC232 Summary The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 7.4), testis (RPKM 6.2) and 25 other tissues See more Orthologs mouse all