LMO2, Official Symbol LMO2provided by HGNC Official Full Name LIM domain only 2provided by HGNC Primary source HGNC:HGNC:6642 See related Ensembl:ENSG00000135363 MIM:180385; AllianceGenome:HGNC:6642 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTG2; LMO-2; RBTN2; RHOM2; RBTNL1 Summary LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008] Expression Broad expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.4) and 24 other tissues See more Orthologs mouse all