HTR3A, Official Symbol HTR3Aprovided by HGNC Official Full Name 5-hydroxytryptamine receptor 3Aprovided by HGNC Primary source HGNC:HGNC:5297 See related Ensembl:ENSG00000166736 MIM:182139; AllianceGenome:HGNC:5297 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R Summary The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 3.0), appendix (RPKM 1.1) and 6 other tissues See more Orthologs mouse all