RHOC, Official Symbol RHOCprovided by HGNC Official Full Name ras homolog family member Cprovided by HGNC Primary source HGNC:HGNC:669 See related Ensembl:ENSG00000155366 MIM:165380; AllianceGenome:HGNC:669 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H9; ARH9; ARHC; RHOH9 Summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 99.1), small intestine (RPKM 91.0) and 24 other tissues See more Orthologs mouse all