UHRF1, Official Symbol UHRF1provided by HGNC Official Full Name ubiquitin like with PHD and ring finger domains 1provided by HGNC Primary source HGNC:HGNC:12556 See related Ensembl:ENSG00000276043 MIM:607990; AllianceGenome:HGNC:12556 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95 Summary This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] Expression Broad expression in bone marrow (RPKM 7.7), lymph node (RPKM 6.3) and 14 other tissues See more Orthologs mouse all