PHLDA3, Official Symbol PHLDA3provided by HGNC Official Full Name pleckstrin homology like domain family A member 3provided by HGNC Primary source HGNC:HGNC:8934 See related Ensembl:ENSG00000174307 MIM:607054; AllianceGenome:HGNC:8934 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIH1 Summary Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues See more Orthologs mouse all