DUSP10, Official Symbol DUSP10provided by HGNC Official Full Name dual specificity phosphatase 10provided by HGNC Primary source HGNC:HGNC:3065 See related Ensembl:ENSG00000143507 MIM:608867; AllianceGenome:HGNC:3065 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MKP5; MKP-5 Summary Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues See more Orthologs mouse all