PYHIN1, Official Symbol PYHIN1provided by HGNC Official Full Name pyrin and HIN domain family member 1provided by HGNC Primary source HGNC:HGNC:28894 See related Ensembl:ENSG00000163564 MIM:612677; AllianceGenome:HGNC:28894 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFIX Summary The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in lymph node (RPKM 3.0), spleen (RPKM 2.1) and 19 other tissues See more Orthologs all