EIF2AK1, Official Symbol EIF2AK1provided by HGNC Official Full Name eukaryotic translation initiation factor 2 alpha kinase 1provided by HGNC Primary source HGNC:HGNC:24921 See related Ensembl:ENSG00000086232 MIM:613635; AllianceGenome:HGNC:24921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCR; HRI; hHRI; LEMSPAD Summary The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in bone marrow (RPKM 37.9), placenta (RPKM 32.2) and 25 other tissues See more Orthologs mouse all