TOPORS, Official Symbol TOPORSprovided by HGNC Official Full Name TOP1 binding arginine/serine rich protein, E3 ubiquitin ligaseprovided by HGNC Primary source HGNC:HGNC:21653 See related Ensembl:ENSG00000197579 MIM:609507; AllianceGenome:HGNC:21653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LUN; RP31; P53BP3; TP53BPL Summary This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in testis (RPKM 10.5), bone marrow (RPKM 10.0) and 25 other tissues See more Orthologs mouse all