SCN4A, Official Symbol SCN4Aprovided by HGNC Official Full Name sodium voltage-gated channel alpha subunit 4provided by HGNC Primary source HGNC:HGNC:10591 See related Ensembl:ENSG00000007314 MIM:603967; AllianceGenome:HGNC:10591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYPP; SkM1; CMS16; HYKPP; NAC1A; HOKPP2; Nav1.4; CMYP22A; Na(V)1.4 Summary Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 9.2), thyroid (RPKM 1.5) and 3 other tissues See more Orthologs mouse all