DLX4, Official Symbol DLX4provided by HGNC Official Full Name distal-less homeobox 4provided by HGNC Primary source HGNC:HGNC:2917 See related Ensembl:ENSG00000108813 MIM:601911; AllianceGenome:HGNC:2917 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BP1; DLX7; DLX8; DLX9; OFC15 Summary Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 1.9), skin (RPKM 0.3) and 3 other tissues See more Orthologs mouse all