POU5F1, Official Symbol POU5F1provided by HGNC Official Full Name POU class 5 homeobox 1provided by HGNC Primary source HGNC:HGNC:9221 See related Ensembl:ENSG00000204531 MIM:164177; AllianceGenome:HGNC:9221 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; Oct3/4 Summary This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013] Expression Broad expression in lung (RPKM 1.3), small intestine (RPKM 1.2) and 21 other tissues See more Orthologs mouse all