HRH3, Official Symbol HRH3provided by HGNC Official Full Name histamine receptor H3provided by HGNC Primary source HGNC:HGNC:5184 See related Ensembl:ENSG00000101180 MIM:604525; AllianceGenome:HGNC:5184 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HH3R; GPCR97 Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 2.9), testis (RPKM 0.2) and 2 other tissues See more Orthologs mouse all