NF2, Official Symbol NF2provided by HGNC Official Full Name NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressorprovided by HGNC Primary source HGNC:HGNC:7773 See related Ensembl:ENSG00000186575 MIM:607379; AllianceGenome:HGNC:7773 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACN; SCH; BANF; SWNV; merlin-1 Summary This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022] Expression Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 5.2) and 25 other tissues See more Orthologs mouse all