CACNA1D, Official Symbol CACNA1Dprovided by HGNC Official Full Name calcium voltage-gated channel subunit alpha1 Dprovided by HGNC Primary source HGNC:HGNC:1391 See related Ensembl:ENSG00000157388 MIM:114206; AllianceGenome:HGNC:1391 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2 Summary Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Broad expression in adrenal (RPKM 4.1), lung (RPKM 2.3) and 16 other tissues See more Orthologs mouse all