SLC7A11, Official Symbol SLC7A11provided by HGNC Official Full Name solute carrier family 7 member 11provided by HGNC Primary source HGNC:HGNC:11059 See related Ensembl:ENSG00000151012 MIM:607933; AllianceGenome:HGNC:11059 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as xCT; CCBR1 Summary This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011] Expression Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues See more Orthologs mouse all