COL15A1, Official Symbol COL15A1provided by HGNC Official Full Name collagen type XV alpha 1 chainprovided by HGNC Primary source HGNC:HGNC:2192 See related Ensembl:ENSG00000204291 MIM:120325; AllianceGenome:HGNC:2192 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013] Expression Broad expression in placenta (RPKM 113.8), fat (RPKM 52.0) and 17 other tissues See more Orthologs mouse all