CBLL1, Official Symbol CBLL1provided by HGNC Official Full Name Cbl proto-oncogene like 1provided by HGNC Primary source HGNC:HGNC:21225 See related Ensembl:ENSG00000105879 MIM:606872; AllianceGenome:HGNC:21225 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAKAI; RNF188 Summary This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in colon (RPKM 9.2), testis (RPKM 4.9) and 25 other tissues See more Orthologs mouse all