TLR9, Official Symbol TLR9provided by HGNC Official Full Name toll like receptor 9provided by HGNC Primary source HGNC:HGNC:15633 See related Ensembl:ENSG00000239732 MIM:605474; AllianceGenome:HGNC:15633 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD289 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017] Expression Broad expression in lymph node (RPKM 2.9), spleen (RPKM 1.9) and 16 other tissues See more Orthologs mouse all