FCHO1, Official Symbol FCHO1provided by HGNC Official Full Name FCH and mu domain containing endocytic adaptor 1provided by HGNC Primary source HGNC:HGNC:29002 See related Ensembl:ENSG00000130475 MIM:613437; AllianceGenome:HGNC:29002 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD76 Summary Enables AP-2 adaptor complex binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in cytosol; nucleoplasm; and plasma membrane. Is active in clathrin-coated pit. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 7.7), spleen (RPKM 6.3) and 14 other tissues See more Orthologs mouse all