ATG7, Official Symbol ATG7provided by HGNC Official Full Name autophagy related 7provided by HGNC Primary source HGNC:HGNC:16935 See related Ensembl:ENSG00000197548 MIM:608760; AllianceGenome:HGNC:16935 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GSA7; APG7L; SCAR31; APG7-LIKE Summary This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in ovary (RPKM 10.0), thyroid (RPKM 8.3) and 25 other tissues See more Orthologs mouse all