WFDC5, Official Symbol WFDC5provided by HGNC Official Full Name WAP four-disulfide core domain 5provided by HGNC Primary source HGNC:HGNC:20477 See related Ensembl:ENSG00000175121 MIM:605161; AllianceGenome:HGNC:20477 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRG5; WAP1; dJ211D12.5 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008] Expression Restricted expression toward skin (RPKM 102.0) See more Orthologs all