RELT, Official Symbol RELTprovided by HGNC Official Full Name RELT TNF receptorprovided by HGNC Primary source HGNC:HGNC:13764 See related Ensembl:ENSG00000054967 MIM:611211; AllianceGenome:HGNC:13764 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AI3C; TRLT; TNFRSF19L Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 25.4), spleen (RPKM 6.1) and 8 other tissues See more Orthologs mouse all