EOMES, Official Symbol EOMESprovided by HGNC Official Full Name eomesoderminprovided by HGNC Primary source HGNC:HGNC:3372 See related Ensembl:ENSG00000163508 MIM:604615; AllianceGenome:HGNC:3372 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TBR2 Summary This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] Expression Biased expression in lymph node (RPKM 5.9), spleen (RPKM 5.3) and 10 other tissues See more Orthologs mouse all