AP2M1, Official Symbol AP2M1provided by HGNC Official Full Name adaptor related protein complex 2 subunit mu 1provided by HGNC Primary source HGNC:HGNC:564 See related Ensembl:ENSG00000161203 MIM:601024; AllianceGenome:HGNC:564 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as mu2; AP50; MRD60; CLAPM1 Summary This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in brain (RPKM 196.0), adrenal (RPKM 156.4) and 25 other tissues See more Orthologs mouse all