TBXAS1, Official Symbol TBXAS1provided by HGNC Official Full Name thromboxane A synthase 1provided by HGNC Primary source HGNC:HGNC:11609 See related Ensembl:ENSG00000059377 MIM:274180; AllianceGenome:HGNC:11609 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Broad expression in spleen (RPKM 5.9), appendix (RPKM 4.4) and 23 other tissues See more Orthologs mouse all