MAP2K1, Official Symbol MAP2K1provided by HGNC Official Full Name mitogen-activated protein kinase kinase 1provided by HGNC Primary source HGNC:HGNC:6840 See related Ensembl:ENSG00000169032 MIM:176872; AllianceGenome:HGNC:6840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEL; CFC3; MEK1; MKK1; MAPKK1; PRKMK1 Summary The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 34.3), fat (RPKM 20.3) and 25 other tissues See more Orthologs mouse all