UNC45B, Official Symbol UNC45Bprovided by HGNC Official Full Name unc-45 myosin chaperone Bprovided by HGNC Primary source HGNC:HGNC:14304 See related Ensembl:ENSG00000141161 MIM:611220; AllianceGenome:HGNC:14304 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMYA4; MFM11; UNC45; CTRCT43; SMUNC45; UNC-45B Summary This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Restricted expression toward heart (RPKM 36.4) See more Orthologs mouse all