SALL3, Official Symbol SALL3provided by HGNC Official Full Name spalt like transcription factor 3provided by HGNC Primary source HGNC:HGNC:10527 See related Ensembl:ENSG00000256463 MIM:605079; AllianceGenome:HGNC:10527 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF796 Summary This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011] Expression Biased expression in brain (RPKM 1.5), prostate (RPKM 0.7) and 2 other tissues See more Orthologs mouse all