WWP2, Official Symbol WWP2provided by HGNC Official Full Name WW domain containing E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:16804 See related Ensembl:ENSG00000198373 MIM:602308; AllianceGenome:HGNC:16804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP2; WWp2-like Summary This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in lung (RPKM 8.8), spleen (RPKM 8.4) and 25 other tissues See more Orthologs mouse all