TLK2, Official Symbol TLK2provided by HGNC Official Full Name tousled like kinase 2provided by HGNC Primary source HGNC:HGNC:11842 See related Ensembl:ENSG00000146872 MIM:608439; AllianceGenome:HGNC:11842 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HsHPK; MRD57; PKU-ALPHA Summary This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more Orthologs mouse all