PRRG2, Official Symbol PRRG2provided by HGNC Official Full Name proline rich and Gla domain 2provided by HGNC Primary source HGNC:HGNC:9470 See related Ensembl:ENSG00000126460 MIM:604429; AllianceGenome:HGNC:9470 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRGP2 Summary The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Broad expression in duodenum (RPKM 5.0), thyroid (RPKM 4.3) and 18 other tissues See more Orthologs mouse all