COL25A1, Official Symbol COL25A1provided by HGNC Official Full Name collagen type XXV alpha 1 chainprovided by HGNC Primary source HGNC:HGNC:18603 See related Ensembl:ENSG00000188517 MIM:610004; AllianceGenome:HGNC:18603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMY; CLAC; CLACP; CFEOM5; CLAC-P Summary This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in testis (RPKM 1.9), fat (RPKM 1.8) and 13 other tissues See more Orthologs mouse all