NTF3, Official Symbol NTF3provided by HGNC Official Full Name neurotrophin 3provided by HGNC Primary source HGNC:HGNC:8023 See related Ensembl:ENSG00000185652 MIM:162660; AllianceGenome:HGNC:8023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NT3; HDNF; NGF2; NT-3; NGF-2 Summary The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 4.8), spleen (RPKM 2.1) and 19 other tissues See more Orthologs mouse all