HOOK1, Official Symbol HOOK1provided by HGNC Official Full Name hook microtubule tethering protein 1provided by HGNC Primary source HGNC:HGNC:19884 See related Ensembl:ENSG00000134709 MIM:607820; AllianceGenome:HGNC:19884 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HK1 Summary This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 15.7), colon (RPKM 10.0) and 21 other tissues See more Orthologs mouse all