EIF3D, Official Symbol EIF3Dprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Dprovided by HGNC Primary source HGNC:HGNC:3278 See related Ensembl:ENSG00000100353 MIM:603915; AllianceGenome:HGNC:3278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3S7; eIF3-p66; eIF3-zeta Summary Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 83.0), lymph node (RPKM 75.1) and 25 other tissues See more Orthologs mouse all