CEL, Official Symbol CELprovided by HGNC Official Full Name carboxyl ester lipaseprovided by HGNC Primary source HGNC:HGNC:1848 See related Ensembl:ENSG00000170835 MIM:114840; AllianceGenome:HGNC:1848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8 Summary The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008] Expression Restricted expression toward pancreas (RPKM 14647.9) See more Orthologs mouse all