RNF43, Official Symbol RNF43provided by HGNC Official Full Name ring finger protein 43provided by HGNC Primary source HGNC:HGNC:18505 See related Ensembl:ENSG00000108375 MIM:612482; AllianceGenome:HGNC:18505 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as URCC; SSPCS; RNF124 Summary The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] Expression Broad expression in duodenum (RPKM 7.1), colon (RPKM 6.1) and 24 other tissues See more Orthologs mouse all