NKX1-1, Official Symbol NKX1-1provided by HGNC Official Full Name NK1 homeobox 1provided by HGNC Primary source HGNC:HGNC:24975 See related Ensembl:ENSG00000235608 MIM:617869; AllianceGenome:HGNC:24975 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAX2; HSPX153; NKX-1.1 Summary This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all