MRPL10, Official Symbol MRPL10provided by HGNC Official Full Name mitochondrial ribosomal protein L10provided by HGNC Primary source HGNC:HGNC:14055 See related Ensembl:ENSG00000159111 MIM:611825; AllianceGenome:HGNC:14055 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L10MT; MRPL8; RPML8; uL10m; MRP-L8; MRP-L10 Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in ovary (RPKM 25.7), heart (RPKM 18.3) and 25 other tissues See more Orthologs mouse all