NOS1AP, Official Symbol NOS1APprovided by HGNC Official Full Name nitric oxide synthase 1 adaptor proteinprovided by HGNC Primary source HGNC:HGNC:16859 See related Ensembl:ENSG00000198929 MIM:605551; AllianceGenome:HGNC:16859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAPON; NPHS22; 6330408P19Rik Summary This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009] Expression Biased expression in brain (RPKM 5.4), adrenal (RPKM 1.1) and 11 other tissues See more Orthologs mouse all