PROX1, Official Symbol PROX1provided by HGNC Official Full Name prospero homeobox 1provided by HGNC Primary source HGNC:HGNC:9459 See related Ensembl:ENSG00000117707 MIM:601546; AllianceGenome:HGNC:9459 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Expression Biased expression in liver (RPKM 20.2), adrenal (RPKM 5.1) and 13 other tissues See more Orthologs mouse all