GH1, Official Symbol GH1provided by HGNC Official Full Name growth hormone 1provided by HGNC Primary source HGNC:HGNC:4261 See related Ensembl:ENSG00000259384 MIM:139250; AllianceGenome:HGNC:4261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GH; GHN; GH-N; GHB5; IGHD2; hGH-N; IGHD1A; IGHD1B Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008] Expression Restricted expression toward placenta (RPKM 13.6) See more Orthologs mouse all