BCHE, Official Symbol BCHEprovided by HGNC Official Full Name butyrylcholinesteraseprovided by HGNC Primary source HGNC:HGNC:983 See related Ensembl:ENSG00000114200 MIM:177400; AllianceGenome:HGNC:983 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E1; CHE1; CHE2; BCHED Summary This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016] Expression Biased expression in liver (RPKM 60.4), brain (RPKM 16.9) and 12 other tissues See more Orthologs mouse all