CYTH4, Official Symbol CYTH4provided by HGNC Official Full Name cytohesin 4provided by HGNC Primary source HGNC:HGNC:9505 See related Ensembl:ENSG00000100055 MIM:606514; AllianceGenome:HGNC:9505 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYT4; PSCD4; DJ63G5.1; cytohesin-4 Summary This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] Expression Broad expression in appendix (RPKM 28.0), spleen (RPKM 22.5) and 20 other tissues See more Orthologs mouse all