CHRNE, Official Symbol CHRNEprovided by HGNC Official Full Name cholinergic receptor nicotinic epsilon subunitprovided by HGNC Primary source HGNC:HGNC:1966 See related Ensembl:ENSG00000108556 MIM:100725; AllianceGenome:HGNC:1966 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGI; FIM1; FIMG; ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; FIMG1; SCCMS; CMS1A1 Summary Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009] Expression Broad expression in heart (RPKM 15.8), skin (RPKM 3.3) and 20 other tissues See more Orthologs mouse all