FUT3, Official Symbol FUT3provided by HGNC Official Full Name fucosyltransferase 3 (Lewis blood group)provided by HGNC Primary source HGNC:HGNC:4014 See related Ensembl:ENSG00000171124 MIM:111100; AllianceGenome:HGNC:4014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LE; Les; FT3B; CD174; FucT-III Summary The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020] Annotation information Annotation category: suggests misassembly Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process. Expression Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more Orthologs all