NECTIN4, Official Symbol NECTIN4provided by HGNC Official Full Name nectin cell adhesion molecule 4provided by HGNC Primary source HGNC:HGNC:19688 See related Ensembl:ENSG00000143217 MIM:609607; AllianceGenome:HGNC:19688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LNIR; PRR4; EDSS1; PVRL4; nectin-4 Summary This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] Expression Biased expression in skin (RPKM 30.6), esophagus (RPKM 23.7) and 7 other tissues See more Orthologs mouse all