TSG101, Official Symbol TSG101provided by HGNC Official Full Name tumor susceptibility 101provided by HGNC Primary source HGNC:HGNC:15971 See related Ensembl:ENSG00000074319 MIM:601387; AllianceGenome:HGNC:15971 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSG10; VPS23 Summary The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 34.7), adrenal (RPKM 31.6) and 25 other tissues See more Orthologs mouse all