PTPN7, Official Symbol PTPN7provided by HGNC Official Full Name protein tyrosine phosphatase non-receptor type 7provided by HGNC Primary source HGNC:HGNC:9659 See related Ensembl:ENSG00000143851 MIM:176889; AllianceGenome:HGNC:9659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010] Expression Biased expression in bone marrow (RPKM 19.6), lymph node (RPKM 18.1) and 11 other tissues See more Orthologs mouse all