TSHZ3, Official Symbol TSHZ3provided by HGNC Official Full Name teashirt zinc finger homeobox 3provided by HGNC Primary source HGNC:HGNC:30700 See related Ensembl:ENSG00000121297 MIM:614119; AllianceGenome:HGNC:30700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSH3; ZNF537 Summary This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016] Expression Broad expression in ovary (RPKM 16.6), endometrium (RPKM 15.6) and 19 other tissues See more Orthologs mouse all