TMPRSS4, Official Symbol TMPRSS4provided by HGNC Official Full Name transmembrane serine protease 4provided by HGNC Primary source HGNC:HGNC:11878 See related Ensembl:ENSG00000137648 MIM:606565; AllianceGenome:HGNC:11878 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAP2; CAPH2; MT-SP2; TMPRSS3 Summary This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Biased expression in colon (RPKM 31.0), urinary bladder (RPKM 28.2) and 8 other tissues See more Orthologs mouse all