WDR5, Official Symbol WDR5provided by HGNC Official Full Name WD repeat domain 5provided by HGNC Primary source HGNC:HGNC:12757 See related Ensembl:ENSG00000196363 MIM:609012; AllianceGenome:HGNC:12757 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIG3; SWD3; BIG-3; CFAP89 Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 24.2), skin (RPKM 8.5) and 25 other tissues See more Orthologs mouse all