SGPL1, Official Symbol SGPL1provided by HGNC Official Full Name sphingosine-1-phosphate lyase 1provided by HGNC Primary source HGNC:HGNC:10817 See related Ensembl:ENSG00000166224 MIM:603729; AllianceGenome:HGNC:10817 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPL; RENI; S1PL; NPHS14 Summary Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in urinary bladder (RPKM 14.9), skin (RPKM 13.8) and 25 other tissues See more Orthologs mouse all