TCAP, Official Symbol TCAPprovided by HGNC Official Full Name titin-capprovided by HGNC Primary source HGNC:HGNC:11610 See related Ensembl:ENSG00000173991 MIM:604488; AllianceGenome:HGNC:11610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TELE; CMD1N; CMH25; T-cap; LGMD2G; LGMDR7; telethonin Summary Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008] Expression Restricted expression toward heart (RPKM 1072.6) See more Orthologs mouse all