TLE5, Official Symbol TLE5provided by HGNC Official Full Name TLE family member 5, transcriptional modulatorprovided by HGNC Primary source HGNC:HGNC:307 See related Ensembl:ENSG00000104964 MIM:600188; AllianceGenome:HGNC:307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AES; GRG; ESP1; GRG5; AES-1; AES-2; Grg-5 Summary The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 135.6), spleen (RPKM 116.8) and 25 other tissues See more Orthologs mouse all