PDE6G, Official Symbol PDE6Gprovided by HGNC Official Full Name phosphodiesterase 6Gprovided by HGNC Primary source HGNC:HGNC:8789 See related Ensembl:ENSG00000185527 MIM:180073; AllianceGenome:HGNC:8789 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDEG; RP57 Summary This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009] Expression Biased expression in spleen (RPKM 3.3), lymph node (RPKM 1.9) and 12 other tissues See more Orthologs mouse all