RAPGEF3, Official Symbol RAPGEF3provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 3provided by HGNC Primary source HGNC:HGNC:16629 See related Ensembl:ENSG00000079337 MIM:606057; AllianceGenome:HGNC:16629 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI Summary Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including positive regulation of protein modification process; regulation of actin cytoskeleton organization; and regulation of syncytium formation by plasma membrane fusion. Located in filopodium; lamellipodium; and microvillus. Colocalizes with cortical actin cytoskeleton and plasma membrane. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 15.0), thyroid (RPKM 13.2) and 22 other tissues See more Orthologs mouse all