CXCL12, Official Symbol CXCL12provided by HGNC Official Full Name C-X-C motif chemokine ligand 12provided by HGNC Primary source HGNC:HGNC:10672 See related Ensembl:ENSG00000107562 MIM:600835; AllianceGenome:HGNC:10672 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12 Summary This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] Expression Broad expression in endometrium (RPKM 50.4), spleen (RPKM 44.2) and 23 other tissues See more Orthologs mouse all