ZC3HAV1, Official Symbol ZC3HAV1provided by HGNC Official Full Name zinc finger CCCH-type containing, antiviral 1provided by HGNC Primary source HGNC:HGNC:23721 See related Ensembl:ENSG00000105939 MIM:607312; AllianceGenome:HGNC:23721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2 Summary This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues See more Orthologs mouse all