EIF2B3, Official Symbol EIF2B3provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit gammaprovided by HGNC Primary source HGNC:HGNC:3259 See related Ensembl:ENSG00000070785 MIM:606273; AllianceGenome:HGNC:3259 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM3; EIF-2B; EIF2Bgamma Summary The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in fat (RPKM 9.9), testis (RPKM 8.8) and 25 other tissues See more Orthologs mouse all