DUS2, Official Symbol DUS2provided by HGNC Official Full Name dihydrouridine synthase 2provided by HGNC Primary source HGNC:HGNC:26014 See related Ensembl:ENSG00000167264 MIM:609707; AllianceGenome:HGNC:26014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMM1; DUS2L; URLC8 Summary This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012] Expression Broad expression in testis (RPKM 12.7), lymph node (RPKM 5.7) and 24 other tissues See more Orthologs mouse all