DNAJB5, Official Symbol DNAJB5provided by HGNC Official Full Name DnaJ heat shock protein family (Hsp40) member B5provided by HGNC Primary source HGNC:HGNC:14887 See related Ensembl:ENSG00000137094 MIM:611328; AllianceGenome:HGNC:14887 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hsc40 Summary This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017] Expression Broad expression in heart (RPKM 17.5), brain (RPKM 13.1) and 21 other tissues See more Orthologs mouse all