CLDN1, Official Symbol CLDN1provided by HGNC Official Full Name claudin 1provided by HGNC Primary source HGNC:HGNC:2032 See related Ensembl:ENSG00000163347 MIM:603718; AllianceGenome:HGNC:2032 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLD1; SEMP1; ILVASC Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 138.8), liver (RPKM 107.2) and 6 other tissues See more Orthologs mouse all