IL16, Official Symbol IL16provided by HGNC Official Full Name interleukin 16provided by HGNC Primary source HGNC:HGNC:5980 See related Ensembl:ENSG00000172349 MIM:603035; AllianceGenome:HGNC:5980 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCF; NIL16; PRIL16; prIL-16 Summary The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] Expression Broad expression in lymph node (RPKM 15.8), spleen (RPKM 12.1) and 20 other tissues See more Orthologs mouse all