NHERF2, Official Symbol NHERF2provided by HGNC Official Full Name NHERF family PDZ scaffold protein 2provided by HGNC Primary source HGNC:HGNC:11076 See related Ensembl:ENSG00000065054 MIM:606553; AllianceGenome:HGNC:11076 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIP1; OCTS2; SIP-1; TKA-1; E3KARP; NHE3RF2; NHERF-2; SLC9A3R2 Summary This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Expression Broad expression in fat (RPKM 26.8), lung (RPKM 19.5) and 22 other tissues See more Orthologs mouse all