ZFR, Official Symbol ZFRprovided by HGNC Official Full Name zinc finger RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:17277 See related Ensembl:ENSG00000056097 MIM:615635; AllianceGenome:HGNC:17277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFR1; SPG71 Summary This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 34.3), testis (RPKM 25.1) and 25 other tissues See more Orthologs mouse all