GPR78, Official Symbol GPR78provided by HGNC Official Full Name G protein-coupled receptor 78provided by HGNC Primary source HGNC:HGNC:4528 See related Ensembl:ENSG00000155269 MIM:606921; AllianceGenome:HGNC:4528 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011] Expression Biased expression in placenta (RPKM 2.0), esophagus (RPKM 0.8) and 1 other tissue See more Orthologs all