TFAP2B, Official Symbol TFAP2Bprovided by HGNC Official Full Name transcription factor AP-2 betaprovided by HGNC Primary source HGNC:HGNC:11743 See related Ensembl:ENSG00000008196 MIM:601601; AllianceGenome:HGNC:11743 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDA2; AP-2B; AP2-B; AP-2beta Summary This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 3.0), skin (RPKM 2.7) and 4 other tissues See more Orthologs mouse all