HOXB3, Official Symbol HOXB3provided by HGNC Official Full Name homeobox B3provided by HGNC Primary source HGNC:HGNC:5114 See related Ensembl:ENSG00000120093 MIM:142966; AllianceGenome:HGNC:5114 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX2; HOX2G; Hox-2.7 Summary This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 1.6), fat (RPKM 1.3) and 21 other tissues See more Orthologs mouse all