UCN3, Official Symbol UCN3provided by HGNC Official Full Name urocortin 3provided by HGNC Primary source HGNC:HGNC:17781 See related Ensembl:ENSG00000178473 MIM:605901; AllianceGenome:HGNC:17781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCP; SPC; UCNIII Summary This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016] Expression Biased expression in duodenum (RPKM 4.8), small intestine (RPKM 3.4) and 8 other tissues See more Orthologs mouse all