TNFRSF13C, Official Symbol TNFRSF13Cprovided by HGNC Official Full Name TNF receptor superfamily member 13Cprovided by HGNC Primary source HGNC:HGNC:17755 See related Ensembl:ENSG00000159958 MIM:606269; AllianceGenome:HGNC:17755 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin Summary B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 19.7), lymph node (RPKM 17.1) and 5 other tissues See more Orthologs mouse all