NUDT5, Official Symbol NUDT5provided by HGNC Official Full Name nudix hydrolase 5provided by HGNC Primary source HGNC:HGNC:8052 See related Ensembl:ENSG00000165609 MIM:609230; AllianceGenome:HGNC:8052 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YSA1; YSA1H; YSAH1; hNUDT5 Summary This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in liver (RPKM 12.0), skin (RPKM 11.4) and 25 other tissues See more Orthologs mouse all