PCLO, Official Symbol PCLOprovided by HGNC Official Full Name piccolo presynaptic cytomatrix proteinprovided by HGNC Primary source HGNC:HGNC:13406 See related Ensembl:ENSG00000186472 MIM:604918; AllianceGenome:HGNC:13406 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACZ; PCH3 Summary The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Biased expression in brain (RPKM 4.9), adrenal (RPKM 1.4) and 9 other tissues See more Orthologs mouse all