MGLL, Official Symbol MGLLprovided by HGNC Official Full Name monoglyceride lipaseprovided by HGNC Primary source HGNC:HGNC:17038 See related Ensembl:ENSG00000074416 MIM:609699; AllianceGenome:HGNC:17038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGL; HUK5; MAGL; HU-K5 Summary This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] Expression Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues See more Orthologs mouse all