PPP3CB, Official Symbol PPP3CBprovided by HGNC Official Full Name protein phosphatase 3 catalytic subunit betaprovided by HGNC Primary source HGNC:HGNC:9315 See related Ensembl:ENSG00000107758 MIM:114106; AllianceGenome:HGNC:9315 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNA2; CALNB; CALNA2; PP2Bbeta Summary Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 40.2), fat (RPKM 17.4) and 24 other tissues See more Orthologs mouse all