TM4SF5, Official Symbol TM4SF5provided by HGNC Official Full Name transmembrane 4 L six family member 5provided by HGNC Primary source HGNC:HGNC:11857 See related Ensembl:ENSG00000142484 MIM:604657; AllianceGenome:HGNC:11857 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008] Expression Biased expression in duodenum (RPKM 71.1), small intestine (RPKM 65.8) and 4 other tissues See more Orthologs mouse all