POLG2, Official Symbol POLG2provided by HGNC Official Full Name DNA polymerase gamma 2, accessory subunitprovided by HGNC Primary source HGNC:HGNC:9180 See related Ensembl:ENSG00000256525 MIM:604983; AllianceGenome:HGNC:9180 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HP55; POLB; PEOA4; POLGB; MTPOLB; MTDPS16; MTDPS16A; MTDPS16B; POLG-BETA Summary This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009] Expression Broad expression in testis (RPKM 7.8), lymph node (RPKM 4.4) and 25 other tissues See more Orthologs mouse all