GRM5, Official Symbol GRM5provided by HGNC Official Full Name glutamate metabotropic receptor 5provided by HGNC Primary source HGNC:HGNC:4597 See related Ensembl:ENSG00000168959 MIM:604102; AllianceGenome:HGNC:4597 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as mGlu5; GPRC1E; MGLUR5; PPP1R86 Summary This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Restricted expression toward brain (RPKM 10.2) See more Orthologs mouse all