JCHAIN, Official Symbol JCHAINprovided by HGNC Official Full Name joining chain of multimeric IgA and IgMprovided by HGNC Primary source HGNC:HGNC:5713 See related Ensembl:ENSG00000132465 MIM:147790; AllianceGenome:HGNC:5713 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGJ; JCH; IGCJ Summary Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to other organism; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues See more Orthologs mouse all