DCPS, Official Symbol DCPSprovided by HGNC Official Full Name decapping enzyme, scavengerprovided by HGNC Primary source HGNC:HGNC:29812 See related Ensembl:ENSG00000110063 MIM:610534; AllianceGenome:HGNC:29812 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015 Summary This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5&#8242; mRNA cap structure, which appear in the 3&#8242; &#8594; 5&#8242; mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues See more Orthologs mouse all