SAE1, Official Symbol SAE1provided by HGNC Official Full Name SUMO1 activating enzyme subunit 1provided by HGNC Primary source HGNC:HGNC:30660 See related Ensembl:ENSG00000142230 MIM:613294; AllianceGenome:HGNC:30660 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AOS1; SUA1; UBLE1A; HSPC140 Summary Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in testis (RPKM 24.6), thyroid (RPKM 21.1) and 25 other tissues See more Orthologs mouse all