CA12, Official Symbol CA12provided by HGNC Official Full Name carbonic anhydrase 12provided by HGNC Primary source HGNC:HGNC:1371 See related Ensembl:ENSG00000074410 MIM:603263; AllianceGenome:HGNC:1371 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAXII; CA-XII; T18816; HsT18816 Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014] Expression Biased expression in kidney (RPKM 105.5), skin (RPKM 54.4) and 6 other tissues See more Orthologs mouse all