MVP, Official Symbol MVPprovided by HGNC Official Full Name major vault proteinprovided by HGNC Primary source HGNC:HGNC:7531 See related Ensembl:ENSG00000013364 MIM:605088; AllianceGenome:HGNC:7531 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRP; VAULT1 Summary This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] Expression Ubiquitous expression in colon (RPKM 85.5), small intestine (RPKM 74.9) and 25 other tissues See more Orthologs mouse all