HAMP, Official Symbol HAMPprovided by HGNC Official Full Name hepcidin antimicrobial peptideprovided by HGNC Primary source HGNC:HGNC:15598 See related Ensembl:ENSG00000105697 MIM:606464; AllianceGenome:HGNC:15598 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEPC; PLTR; HFE2B; LEAP1 Summary The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014] Expression Biased expression in liver (RPKM 88.9) and heart (RPKM 10.6) See more Orthologs mouse all