PFAS, Official Symbol PFASprovided by HGNC Official Full Name phosphoribosylformylglycinamidine synthaseprovided by HGNC Primary source HGNC:HGNC:8863 See related Ensembl:ENSG00000178921 MIM:602133; AllianceGenome:HGNC:8863 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PURL; FGAMS; GATD8; FGARAT; FGAR-AT Summary Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 4.9), appendix (RPKM 4.3) and 25 other tissues See more Orthologs mouse all