PRICKLE1, Official Symbol PRICKLE1provided by HGNC Official Full Name prickle planar cell polarity protein 1provided by HGNC Primary source HGNC:HGNC:17019 See related Ensembl:ENSG00000139174 MIM:608500; AllianceGenome:HGNC:17019 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RILP; EPM1B Summary This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009] Expression Broad expression in spleen (RPKM 7.7), endometrium (RPKM 6.7) and 23 other tissues See more Orthologs mouse all