RPS6KA4, Official Symbol RPS6KA4provided by HGNC Official Full Name ribosomal protein S6 kinase A4provided by HGNC Primary source HGNC:HGNC:10433 See related Ensembl:ENSG00000162302 MIM:603606; AllianceGenome:HGNC:10433 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSK2; RSK-B; S6K-alpha-4 Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in spleen (RPKM 12.2), colon (RPKM 9.2) and 25 other tissues See more Orthologs mouse all