SGK1, Official Symbol SGK1provided by HGNC Official Full Name serum/glucocorticoid regulated kinase 1provided by HGNC Primary source HGNC:HGNC:10810 See related Ensembl:ENSG00000118515 MIM:602958; AllianceGenome:HGNC:10810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SGK Summary This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] Expression Broad expression in small intestine (RPKM 111.9), gall bladder (RPKM 85.9) and 24 other tissues See more Orthologs mouse all