SPRR2E, Official Symbol SPRR2Eprovided by HGNC Official Full Name small proline rich protein 2Eprovided by HGNC Primary source HGNC:HGNC:11265 See related Ensembl:ENSG00000203785 MIM:617588; AllianceGenome:HGNC:11265 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014] Expression Restricted expression toward esophagus (RPKM 706.9) See more Orthologs all