MSRB3, Official Symbol MSRB3provided by HGNC Official Full Name methionine sulfoxide reductase B3provided by HGNC Primary source HGNC:HGNC:27375 See related Ensembl:ENSG00000174099 MIM:613719; AllianceGenome:HGNC:27375 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB74 Summary The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010] Expression Broad expression in endometrium (RPKM 66.2), esophagus (RPKM 57.7) and 22 other tissues See more Orthologs mouse all