GADD45A, Official Symbol GADD45Aprovided by HGNC Official Full Name growth arrest and DNA damage inducible alphaprovided by HGNC Primary source HGNC:HGNC:4095 See related Ensembl:ENSG00000116717 MIM:126335; AllianceGenome:HGNC:4095 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDIT1; GADD45 Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] Expression Broad expression in liver (RPKM 72.1), kidney (RPKM 57.9) and 23 other tissues See more Orthologs mouse all