EPHA4, Official Symbol EPHA4provided by HGNC Official Full Name EPH receptor A4provided by HGNC Primary source HGNC:HGNC:3388 See related Ensembl:ENSG00000116106 MIM:602188; AllianceGenome:HGNC:3388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EK8; SEK; HEK8; TYRO1 Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] Expression Broad expression in brain (RPKM 16.1), testis (RPKM 9.3) and 17 other tissues See more Orthologs mouse all