PANK1, Official Symbol PANK1provided by HGNC Official Full Name pantothenate kinase 1provided by HGNC Primary source HGNC:HGNC:8598 See related Ensembl:ENSG00000152782 MIM:606160; AllianceGenome:HGNC:8598 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PANK Summary This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011] Expression Broad expression in liver (RPKM 8.6), kidney (RPKM 7.3) and 16 other tissues See more Orthologs mouse all