PTPN14, Official Symbol PTPN14provided by HGNC Official Full Name protein tyrosine phosphatase non-receptor type 14provided by HGNC Primary source HGNC:HGNC:9647 See related Ensembl:ENSG00000152104 MIM:603155; AllianceGenome:HGNC:9647 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEZ; PTP36; PTPD2; CATLPH Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in skin (RPKM 9.0), kidney (RPKM 5.5) and 23 other tissues See more Orthologs mouse all