SERPINE1, Official Symbol SERPINE1provided by HGNC Official Full Name serpin family E member 1provided by HGNC Primary source HGNC:HGNC:8583 See related Ensembl:ENSG00000106366 MIM:173360; AllianceGenome:HGNC:8583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAI; PAI1; PAI-1; PLANH1 Summary This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Biased expression in gall bladder (RPKM 208.8), placenta (RPKM 164.7) and 7 other tissues See more Orthologs mouse all