ARHGEF1, Official Symbol ARHGEF1provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:681 See related Ensembl:ENSG00000076928 MIM:601855; AllianceGenome:HGNC:681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSC; GEF1; IMD62; LBCL2; SUB1.5; P115-RHOGEF Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 68.4), lymph node (RPKM 64.2) and 24 other tissues See more Orthologs mouse all