PLA2G2A, Official Symbol PLA2G2Aprovided by HGNC Official Full Name phospholipase A2 group IIAprovided by HGNC Primary source HGNC:HGNC:9031 See related Ensembl:ENSG00000188257 MIM:172411; AllianceGenome:HGNC:9031 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2 Summary The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009] Expression Biased expression in colon (RPKM 828.3), small intestine (RPKM 526.6) and 7 other tissues See more Orthologs mouse all