C8G, Official Symbol C8Gprovided by HGNC Official Full Name complement C8 gamma chainprovided by HGNC Primary source HGNC:HGNC:1354 See related Ensembl:ENSG00000176919 MIM:120930; AllianceGenome:HGNC:1354 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C8C Summary The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011] Expression Biased expression in liver (RPKM 36.1), duodenum (RPKM 11.1) and 1 other tissue See more Orthologs mouse all