CTH, Official Symbol CTHprovided by HGNC Official Full Name cystathionine gamma-lyaseprovided by HGNC Primary source HGNC:HGNC:2501 See related Ensembl:ENSG00000116761 MIM:607657; AllianceGenome:HGNC:2501 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGL; CSE Summary This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] Expression Biased expression in liver (RPKM 17.3), adrenal (RPKM 4.0) and 12 other tissues See more Orthologs mouse all