PAPPA2, Official Symbol PAPPA2provided by HGNC Official Full Name pappalysin 2provided by HGNC Primary source HGNC:HGNC:14615 See related Ensembl:ENSG00000116183 MIM:619485; AllianceGenome:HGNC:14615 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSDA; PAPPE; PLAC3; PAPP-E; PAPP-A2 Summary This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] Expression Biased expression in placenta (RPKM 23.7), kidney (RPKM 2.2) and 1 other tissue See more Orthologs mouse all