SERPINF2, Official Symbol SERPINF2provided by HGNC Official Full Name serpin family F member 2provided by HGNC Primary source HGNC:HGNC:9075 See related Ensembl:ENSG00000167711 MIM:613168; AllianceGenome:HGNC:9075 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAP; API; PLI; A2AP; alpha2AP; ALPHA-2-PI Summary This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Biased expression in liver (RPKM 275.1) and kidney (RPKM 42.8) See more Orthologs mouse all