GUCY2C, Official Symbol GUCY2Cprovided by HGNC Official Full Name guanylate cyclase 2Cprovided by HGNC Primary source HGNC:HGNC:4688 See related Ensembl:ENSG00000070019 MIM:601330; AllianceGenome:HGNC:4688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCC; GC-C; HSER; STAR; DIAR6; GUC2C; MECIL; MUCIL Summary This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016] Expression Biased expression in duodenum (RPKM 36.3), small intestine (RPKM 36.1) and 2 other tissues See more Orthologs mouse all