USP16, Official Symbol USP16provided by HGNC Official Full Name ubiquitin specific peptidase 16provided by HGNC Primary source HGNC:HGNC:12614 See related Ensembl:ENSG00000156256 MIM:604735; AllianceGenome:HGNC:12614 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBPM; UBP-M Summary This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 20.1), testis (RPKM 16.3) and 25 other tissues See more Orthologs mouse all