NLRP6, Official Symbol NLRP6provided by HGNC Official Full Name NLR family pyrin domain containing 6provided by HGNC Primary source HGNC:HGNC:22944 See related Ensembl:ENSG00000174885 MIM:609650; AllianceGenome:HGNC:22944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR Summary The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] Expression Biased expression in duodenum (RPKM 17.8), small intestine (RPKM 17.7) and 3 other tissues See more Orthologs mouse all