OTUB1, Official Symbol OTUB1provided by HGNC Official Full Name OTU deubiquitinase, ubiquitin aldehyde binding 1provided by HGNC Primary source HGNC:HGNC:23077 See related Ensembl:ENSG00000167770 MIM:608337; AllianceGenome:HGNC:23077 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTB1; OTU1; HSPC263 Summary The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues See more Orthologs mouse all