GLRX, Official Symbol GLRXprovided by HGNC Official Full Name glutaredoxinprovided by HGNC Primary source HGNC:HGNC:4330 See related Ensembl:ENSG00000173221 MIM:600443; AllianceGenome:HGNC:4330 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRX; GRX1 Summary This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] Expression Broad expression in kidney (RPKM 54.1), small intestine (RPKM 45.6) and 22 other tissues See more Orthologs mouse all