P2RY6, Official Symbol P2RY6provided by HGNC Official Full Name pyrimidinergic receptor P2Y6provided by HGNC Primary source HGNC:HGNC:8543 See related Ensembl:ENSG00000171631 MIM:602451; AllianceGenome:HGNC:8543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2Y6 Summary The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013] Expression Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues See more Orthologs mouse all