APOE, Official Symbol APOEprovided by HGNC Official Full Name apolipoprotein Eprovided by HGNC Primary source HGNC:HGNC:613 See related Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD2; LPG; APO-E; ApoE4; LDLCQ5 Summary The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016] Expression Biased expression in liver (RPKM 1021.7), kidney (RPKM 648.1) and 7 other tissues See more Orthologs mouse all