NSL1, Official Symbol NSL1provided by HGNC Official Full Name NSL1 component of MIS12 kinetochore complexprovided by HGNC Primary source HGNC:HGNC:24548 See related Ensembl:ENSG00000117697 MIM:609174; AllianceGenome:HGNC:24548 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DC8; MIS14; C1orf48 Summary This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in brain (RPKM 2.0), lymph node (RPKM 1.8) and 25 other tissues See more Orthologs mouse all