EDN2, Official Symbol EDN2provided by HGNC Official Full Name endothelin 2provided by HGNC Primary source HGNC:HGNC:3177 See related Ensembl:ENSG00000127129 MIM:131241; AllianceGenome:HGNC:3177 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ET2; ET-2; PPET2 Summary This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] Expression Biased expression in small intestine (RPKM 7.3), esophagus (RPKM 3.9) and 5 other tissues See more Orthologs mouse all