PTPRN2, Official Symbol PTPRN2provided by HGNC Official Full Name protein tyrosine phosphatase receptor type N2provided by HGNC Primary source HGNC:HGNC:9677 See related Ensembl:ENSG00000155093 MIM:601698; AllianceGenome:HGNC:9677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2 Summary This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Expression Broad expression in brain (RPKM 7.2), stomach (RPKM 4.9) and 18 other tissues See more Orthologs mouse all