MOGS, Official Symbol MOGSprovided by HGNC Official Full Name mannosyl-oligosaccharide glucosidaseprovided by HGNC Primary source HGNC:HGNC:24862 See related Ensembl:ENSG00000115275 MIM:601336; AllianceGenome:HGNC:24862 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DER7; GCS1; CDG2B; CWH41 Summary This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in duodenum (RPKM 32.8), placenta (RPKM 24.5) and 25 other tissues See more Orthologs mouse all