CD180, Official Symbol CD180provided by HGNC Official Full Name CD180 moleculeprovided by HGNC Primary source HGNC:HGNC:6726 See related Ensembl:ENSG00000134061 MIM:602226; AllianceGenome:HGNC:6726 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LY64; Ly78; RP105 Summary CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 23.1), spleen (RPKM 12.8) and 10 other tissues See more Orthologs mouse all