FZD6, Official Symbol FZD6provided by HGNC Official Full Name frizzled class receptor 6provided by HGNC Primary source HGNC:HGNC:4044 See related Ensembl:ENSG00000164930 MIM:603409; AllianceGenome:HGNC:4044 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FZ6; FZ-6; HFZ6; NDNC1; NDNC10 Summary This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011] Expression Ubiquitous expression in thyroid (RPKM 15.4), lung (RPKM 14.1) and 25 other tissues See more Orthologs mouse all