BCAM, Official Symbol BCAMprovided by HGNC Official Full Name basal cell adhesion molecule (Lutheran blood group)provided by HGNC Primary source HGNC:HGNC:6722 See related Ensembl:ENSG00000187244 MIM:612773; AllianceGenome:HGNC:6722 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AU; LU; B-CAM; CD239; MSK19; F8/G253 Summary This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] Expression Broad expression in kidney (RPKM 99.8), prostate (RPKM 62.6) and 19 other tissues See more Orthologs mouse all