RAB7A, Official Symbol RAB7Aprovided by HGNC Official Full Name RAB7A, member RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:9788 See related Ensembl:ENSG00000075785 MIM:602298; AllianceGenome:HGNC:9788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAB7; CMT2B; PRO2706 Summary RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 104.7), fat (RPKM 97.2) and 25 other tissues See more Orthologs mouse all