EDNRA, Official Symbol EDNRAprovided by HGNC Official Full Name endothelin receptor type Aprovided by HGNC Primary source HGNC:HGNC:3179 See related Ensembl:ENSG00000151617 MIM:131243; AllianceGenome:HGNC:3179 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ETA; ET-A; ETAR; ETRA; MFDA; ETA-R; hET-AR Summary This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Expression Broad expression in endometrium (RPKM 36.3), ovary (RPKM 19.3) and 18 other tissues See more Orthologs mouse all