MXD3, Official Symbol MXD3provided by HGNC Official Full Name MAX dimerization protein 3provided by HGNC Primary source HGNC:HGNC:14008 See related Ensembl:ENSG00000213347 MIM:609450; AllianceGenome:HGNC:14008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYX; MAD3; BHLHC13 Summary This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008] Expression Ubiquitous expression in small intestine (RPKM 15.2), colon (RPKM 14.3) and 25 other tissues See more Orthologs mouse all