PIAS4, Official Symbol PIAS4provided by HGNC Official Full Name protein inhibitor of activated STAT 4provided by HGNC Primary source HGNC:HGNC:17002 See related Ensembl:ENSG00000105229 MIM:605989; AllianceGenome:HGNC:17002 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIASY; Piasg; ZMIZ6; PIAS-gamma Summary Enables SUMO ligase activity and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of protein sumoylation; and protein sumoylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues See more Orthologs mouse all