DISP1, Official Symbol DISP1provided by HGNC Official Full Name dispatched RND transporter family member 1provided by HGNC Primary source HGNC:HGNC:19711 See related Ensembl:ENSG00000154309 MIM:607502; AllianceGenome:HGNC:19711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DISPA Summary The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 5.0), testis (RPKM 4.5) and 25 other tissues See more Orthologs mouse all