LRRK2, Official Symbol LRRK2provided by HGNC Official Full Name leucine rich repeat kinase 2provided by HGNC Primary source HGNC:HGNC:18618 See related Ensembl:ENSG00000188906 MIM:609007; AllianceGenome:HGNC:18618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARK8; RIPK7; ROCO2; AURA17; DARDARIN Summary This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 31.3), appendix (RPKM 7.6) and 15 other tissues See more Orthologs mouse all