GRK3, Official Symbol GRK3provided by HGNC Official Full Name G protein-coupled receptor kinase 3provided by HGNC Primary source HGNC:HGNC:290 See related Ensembl:ENSG00000100077 MIM:109636; AllianceGenome:HGNC:290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BARK2; ADRBK2 Summary The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues See more Orthologs mouse all