TBX4, Official Symbol TBX4provided by HGNC Official Full Name T-box transcription factor 4provided by HGNC Primary source HGNC:HGNC:11603 See related Ensembl:ENSG00000121075 MIM:601719; AllianceGenome:HGNC:11603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPS; ICPPS; PAPPAS Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 16.7), placenta (RPKM 12.0) and 2 other tissues See more Orthologs mouse all