NOP10, Official Symbol NOP10provided by HGNC Official Full Name NOP10 ribonucleoproteinprovided by HGNC Primary source HGNC:HGNC:14378 See related Ensembl:ENSG00000182117 MIM:606471; AllianceGenome:HGNC:14378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKCB1; NOLA3; CHINE2; NOP10P; PFBMFT9 Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 45.9), spleen (RPKM 43.6) and 25 other tissues See more Orthologs mouse all