IGSF8, Official Symbol IGSF8provided by HGNC Official Full Name immunoglobulin superfamily member 8provided by HGNC Primary source HGNC:HGNC:17813 See related Ensembl:ENSG00000162729 MIM:606644; AllianceGenome:HGNC:17813 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1 Summary This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in brain (RPKM 17.6), skin (RPKM 9.6) and 24 other tissues See more Orthologs mouse all