LMNB2, Official Symbol LMNB2provided by HGNC Official Full Name lamin B2provided by HGNC Primary source HGNC:HGNC:6638 See related Ensembl:ENSG00000176619 MIM:150341; AllianceGenome:HGNC:6638 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPM9; LMN2; LAMB2; MCPH27 Summary This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012] Expression Ubiquitous expression in placenta (RPKM 13.1), colon (RPKM 11.1) and 25 other tissues See more Orthologs mouse all