PNLIP, Official Symbol PNLIPprovided by HGNC Official Full Name pancreatic lipaseprovided by HGNC Primary source HGNC:HGNC:9155 See related Ensembl:ENSG00000175535 MIM:246600; AllianceGenome:HGNC:9155 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PL; PTL; PNLIPD Summary This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016] Expression Restricted expression toward pancreas (RPKM 53831.3) See more Orthologs mouse all