PIN1, Official Symbol PIN1provided by HGNC Official Full Name peptidylprolyl cis/trans isomerase, NIMA-interacting 1provided by HGNC Primary source HGNC:HGNC:8988 See related Ensembl:ENSG00000127445 MIM:601052; AllianceGenome:HGNC:8988 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOD; UBL5 Summary Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] Expression Ubiquitous expression in brain (RPKM 30.9), testis (RPKM 25.2) and 25 other tissues See more Orthologs mouse all