TFF3, Official Symbol TFF3provided by HGNC Official Full Name trefoil factor 3provided by HGNC Primary source HGNC:HGNC:11757 See related Ensembl:ENSG00000160180 MIM:600633; AllianceGenome:HGNC:11757 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ITF; P1B; TFI Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 367.8), thyroid (RPKM 187.9) and 4 other tissues See more Orthologs mouse all