INPPL1, Official Symbol INPPL1provided by HGNC Official Full Name inositol polyphosphate phosphatase like 1provided by HGNC Primary source HGNC:HGNC:6080 See related Ensembl:ENSG00000165458 MIM:600829; AllianceGenome:HGNC:6080 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPSMD; SHIP2 Summary The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] Expression Ubiquitous expression in placenta (RPKM 19.8), thyroid (RPKM 19.6) and 25 other tissues See more Orthologs mouse all