TGM3, Official Symbol TGM3provided by HGNC Official Full Name transglutaminase 3provided by HGNC Primary source HGNC:HGNC:11779 See related Ensembl:ENSG00000125780 MIM:600238; AllianceGenome:HGNC:11779 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TGE; UHS2 Summary Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008] Expression Restricted expression toward esophagus (RPKM 758.5) See more Orthologs mouse all