NFYA, Official Symbol NFYAprovided by HGNC Official Full Name nuclear transcription factor Y subunit alphaprovided by HGNC Primary source HGNC:HGNC:7804 See related Ensembl:ENSG00000001167 MIM:189903; AllianceGenome:HGNC:7804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAP2; CBF-A; CBF-B; NF-YA Summary The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 5.4), brain (RPKM 3.2) and 25 other tissues See more Orthologs mouse all