PDE3A, Official Symbol PDE3Aprovided by HGNC Official Full Name phosphodiesterase 3Aprovided by HGNC Primary source HGNC:HGNC:8778 See related Ensembl:ENSG00000172572 MIM:123805; AllianceGenome:HGNC:8778 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A Summary This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] Expression Broad expression in heart (RPKM 15.7), placenta (RPKM 7.2) and 17 other tissues See more Orthologs mouse all