CPAMD8, Official Symbol CPAMD8provided by HGNC Official Full Name C3 and PZP like alpha-2-macroglobulin domain containing 8provided by HGNC Primary source HGNC:HGNC:23228 See related Ensembl:ENSG00000160111 MIM:608841; AllianceGenome:HGNC:23228 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VIP; ASGD8; K-CAP Summary This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017] Expression Biased expression in lung (RPKM 10.3), prostate (RPKM 7.9) and 12 other tissues See more Orthologs all