CCR7, Official Symbol CCR7provided by HGNC Official Full Name C-C motif chemokine receptor 7provided by HGNC Primary source HGNC:HGNC:1608 See related Ensembl:ENSG00000126353 MIM:600242; AllianceGenome:HGNC:1608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7 Summary The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues See more Orthologs mouse all