APLNR, Official Symbol APLNRprovided by HGNC Official Full Name apelin receptorprovided by HGNC Primary source HGNC:HGNC:339 See related Ensembl:ENSG00000134817 MIM:600052; AllianceGenome:HGNC:339 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APJ; APJR; HG11; AGTRL1 Summary This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009] Expression Biased expression in spleen (RPKM 57.2), placenta (RPKM 39.1) and 11 other tissues See more Orthologs mouse all