DMRT1, Official Symbol DMRT1provided by HGNC Official Full Name doublesex and mab-3 related transcription factor 1provided by HGNC Primary source HGNC:HGNC:2934 See related Ensembl:ENSG00000137090 MIM:602424; AllianceGenome:HGNC:2934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DMT1; CT154 Summary This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 15.0) See more Orthologs mouse all