COTL1, Official Symbol COTL1provided by HGNC Official Full Name coactosin like F-actin binding protein 1provided by HGNC Primary source HGNC:HGNC:18304 See related Ensembl:ENSG00000103187 MIM:606748; AllianceGenome:HGNC:18304 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLP Summary This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues See more Orthologs mouse all