HTR2B, Official Symbol HTR2Bprovided by HGNC Official Full Name 5-hydroxytryptamine receptor 2Bprovided by HGNC Primary source HGNC:HGNC:5294 See related Ensembl:ENSG00000135914 MIM:601122; AllianceGenome:HGNC:5294 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 5-HT2B; 5-HT-2B; 5-HT(2B) Summary This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016] Expression Biased expression in endometrium (RPKM 10.3), adrenal (RPKM 7.1) and 8 other tissues See more Orthologs mouse all