RGS1, Official Symbol RGS1provided by HGNC Official Full Name regulator of G protein signaling 1provided by HGNC Primary source HGNC:HGNC:9991 See related Ensembl:ENSG00000090104 MIM:600323; AllianceGenome:HGNC:9991 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1R20; BL34; IER1; IR20; HEL-S-87 Summary This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 110.9), lymph node (RPKM 72.3) and 17 other tissues See more Orthologs mouse all