NELFB, Official Symbol NELFBprovided by HGNC Official Full Name negative elongation factor complex member Bprovided by HGNC Primary source HGNC:HGNC:24324 See related Ensembl:ENSG00000188986 MIM:611180; AllianceGenome:HGNC:24324 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COBRA1; NELF-B Summary NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 16.5), fat (RPKM 16.5) and 25 other tissues See more Orthologs mouse all