CBY1, Official Symbol CBY1provided by HGNC Official Full Name chibby 1, beta catenin antagonistprovided by HGNC Primary source HGNC:HGNC:1307 See related Ensembl:ENSG00000100211 MIM:607757; AllianceGenome:HGNC:1307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A Summary Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues See more Orthologs mouse all