S1PR1, Official Symbol S1PR1provided by HGNC Official Full Name sphingosine-1-phosphate receptor 1provided by HGNC Primary source HGNC:HGNC:3165 See related Ensembl:ENSG00000170989 MIM:601974; AllianceGenome:HGNC:3165 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362 Summary The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues See more Orthologs mouse all