APBB1, Official Symbol APBB1provided by HGNC Official Full Name amyloid beta precursor protein binding family B member 1provided by HGNC Primary source HGNC:HGNC:581 See related Ensembl:ENSG00000166313 MIM:602709; AllianceGenome:HGNC:581 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIR; FE65; MGC:9072 Summary The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in brain (RPKM 44.0), ovary (RPKM 11.7) and 17 other tissues See more Orthologs mouse all