PLEKHG2, Official Symbol PLEKHG2provided by HGNC Official Full Name pleckstrin homology and RhoGEF domain containing G2provided by HGNC Primary source HGNC:HGNC:29515 See related Ensembl:ENSG00000090924 MIM:611893; AllianceGenome:HGNC:29515 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLG; LDAMD; ARHGEF42; CTB-60E11.4 Summary The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects in this gene have been associated with leukodystrophy and acquired microcephaly with or without dystonia. [provided by RefSeq, May 2017] Expression Ubiquitous expression in endometrium (RPKM 7.0), appendix (RPKM 6.7) and 25 other tissues See more Orthologs mouse all