MST1R, Official Symbol MST1Rprovided by HGNC Official Full Name macrophage stimulating 1 receptorprovided by HGNC Primary source HGNC:HGNC:7381 See related Ensembl:ENSG00000164078 MIM:600168; AllianceGenome:HGNC:7381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron Summary This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016] Expression Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues See more Orthologs mouse all