VWF, Official Symbol VWFprovided by HGNC Official Full Name von Willebrand factorprovided by HGNC Primary source HGNC:HGNC:12726 See related Ensembl:ENSG00000110799 MIM:613160; AllianceGenome:HGNC:12726 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWD; F8VWF Summary This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015] Expression Broad expression in fat (RPKM 93.4), lung (RPKM 58.7) and 16 other tissues See more Orthologs mouse all