CCT5, Official Symbol CCT5provided by HGNC Official Full Name chaperonin containing TCP1 subunit 5provided by HGNC Primary source HGNC:HGNC:1618 See related Ensembl:ENSG00000150753 MIM:610150; AllianceGenome:HGNC:1618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCTE; HEL-S-69; PNAS-102; CCT-epsilon; TCP-1-epsilon Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015] Expression Ubiquitous expression in testis (RPKM 38.0), appendix (RPKM 31.8) and 25 other tissues See more Orthologs mouse all