ACSL6, Official Symbol ACSL6provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 6provided by HGNC Primary source HGNC:HGNC:16496 See related Ensembl:ENSG00000164398 MIM:604443; AllianceGenome:HGNC:16496 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS2; FACL6; LACS2; LACS5; LACS 6 Summary The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Biased expression in brain (RPKM 19.2), testis (RPKM 8.4) and 5 other tissues See more Orthologs mouse all