ILK, Official Symbol ILKprovided by HGNC Official Full Name integrin linked kinaseprovided by HGNC Primary source HGNC:HGNC:6040 See related Ensembl:ENSG00000166333 MIM:602366; AllianceGenome:HGNC:6040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P59; ILK-1; ILK-2; p59ILK; HEL-S-28 Summary This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more Orthologs mouse all