PARD6A, Official Symbol PARD6Aprovided by HGNC Official Full Name par-6 family cell polarity regulator alphaprovided by HGNC Primary source HGNC:HGNC:15943 See related Ensembl:ENSG00000102981 MIM:607484; AllianceGenome:HGNC:15943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha Summary This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 9.8), brain (RPKM 5.0) and 23 other tissues See more Orthologs mouse all