CPSF3, Official Symbol CPSF3provided by HGNC Official Full Name cleavage and polyadenylation specific factor 3provided by HGNC Primary source HGNC:HGNC:2326 See related Ensembl:ENSG00000119203 MIM:606029; AllianceGenome:HGNC:2326 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPSF73; NEDMHS; CPSF-73; NEDMHSN Summary This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012] Expression Broad expression in testis (RPKM 20.7), lymph node (RPKM 8.6) and 24 other tissues See more Orthologs mouse all