APOL3, Official Symbol APOL3provided by HGNC Official Full Name apolipoprotein L3provided by HGNC Primary source HGNC:HGNC:14868 See related Ensembl:ENSG00000128284 MIM:607253; AllianceGenome:HGNC:14868 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CG121; CG12_1; APOLIII; apoL-III Summary This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] Expression Broad expression in spleen (RPKM 16.1), fat (RPKM 13.1) and 24 other tissues See more Orthologs all