ADAMTS8, Official Symbol ADAMTS8provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 8provided by HGNC Primary source HGNC:HGNC:224 See related Ensembl:ENSG00000134917 MIM:605175; AllianceGenome:HGNC:224 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as METH2; ADAM-TS8 Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016] Expression Biased expression in lung (RPKM 12.6), appendix (RPKM 7.0) and 8 other tissues See more Orthologs mouse all