ABCC1, Official Symbol ABCC1provided by HGNC Official Full Name ATP binding cassette subfamily C member 1provided by HGNC Primary source HGNC:HGNC:51 See related Ensembl:ENSG00000103222 MIM:158343; AllianceGenome:HGNC:51 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRP; ABCC; GS-X; MRP1; ABC29; DFNA77 Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in testis (RPKM 13.5), esophagus (RPKM 9.9) and 25 other tissues See more Orthologs mouse all