SPRY4, Official Symbol SPRY4provided by HGNC Official Full Name sprouty RTK signaling antagonist 4provided by HGNC Primary source HGNC:HGNC:15533 See related Ensembl:ENSG00000187678 MIM:607984; AllianceGenome:HGNC:15533 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HH17 Summary This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Broad expression in lung (RPKM 7.4), adrenal (RPKM 7.0) and 24 other tissues See more Orthologs mouse all