ITGA2, Official Symbol ITGA2provided by HGNC Official Full Name integrin subunit alpha 2provided by HGNC Primary source HGNC:HGNC:6137 See related Ensembl:ENSG00000164171 MIM:192974; AllianceGenome:HGNC:6137 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2 Summary This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Broad expression in skin (RPKM 8.4), adrenal (RPKM 7.9) and 21 other tissues See more Orthologs mouse all