MAPK10, Official Symbol MAPK10provided by HGNC Official Full Name mitogen-activated protein kinase 10provided by HGNC Primary source HGNC:HGNC:6872 See related Ensembl:ENSG00000109339 MIM:602897; AllianceGenome:HGNC:6872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] Expression Biased expression in brain (RPKM 15.3), fat (RPKM 4.4) and 11 other tissues See more Orthologs mouse all