DGCR8, Official Symbol DGCR8provided by HGNC Official Full Name DGCR8 microprocessor complex subunitprovided by HGNC Primary source HGNC:HGNC:2847 See related Ensembl:ENSG00000128191 MIM:609030; AllianceGenome:HGNC:2847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gy1; pasha; DGCRK6; C22orf12 Summary This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in testis (RPKM 13.8), placenta (RPKM 10.2) and 25 other tissues See more Orthologs mouse all