GMDS, Official Symbol GMDSprovided by HGNC Official Full Name GDP-mannose 4,6-dehydrataseprovided by HGNC Primary source HGNC:HGNC:4369 See related Ensembl:ENSG00000112699 MIM:602884; AllianceGenome:HGNC:4369 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GMD; SDR3E1 Summary GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009] Expression Broad expression in colon (RPKM 6.8), stomach (RPKM 6.6) and 23 other tissues See more Orthologs mouse all