PDE8B, Official Symbol PDE8Bprovided by HGNC Official Full Name phosphodiesterase 8Bprovided by HGNC Primary source HGNC:HGNC:8794 See related Ensembl:ENSG00000113231 MIM:603390; AllianceGenome:HGNC:8794 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADSD; PPNAD3 Summary The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] Expression Biased expression in thyroid (RPKM 82.4), brain (RPKM 15.1) and 5 other tissues See more Orthologs mouse all