HLA-DQA2, Official Symbol HLA-DQA2provided by HGNC Official Full Name major histocompatibility complex, class II, DQ alpha 2provided by HGNC Primary source HGNC:HGNC:4943 See related Ensembl:ENSG00000237541 MIM:613503; AllianceGenome:HGNC:4943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DQA1; HLA-DCA; HLA-DXA; HLADQA2; DC-alpha; DX-ALPHA Summary This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010] Expression Broad expression in lymph node (RPKM 32.9), spleen (RPKM 26.8) and 20 other tissues See more Orthologs all