JPH2, Official Symbol JPH2provided by HGNC Official Full Name junctophilin 2provided by HGNC Primary source HGNC:HGNC:14202 See related Ensembl:ENSG00000149596 MIM:605267; AllianceGenome:HGNC:14202 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JP2; JP-2; CMD2E; CMH17 Summary Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 14.9), prostate (RPKM 9.1) and 11 other tissues See more Orthologs mouse all