TERF1, Official Symbol TERF1provided by HGNC Official Full Name telomeric repeat binding factor 1provided by HGNC Primary source HGNC:HGNC:11728 See related Ensembl:ENSG00000147601 MIM:600951; AllianceGenome:HGNC:11728 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS Summary This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products. [provided by RefSeq, Aug 2022] Expression Ubiquitous expression in brain (RPKM 11.2), ovary (RPKM 9.8) and 25 other tissues See more Orthologs mouse all