PLCD1, Official Symbol PLCD1provided by HGNC Official Full Name phospholipase C delta 1provided by HGNC Primary source HGNC:HGNC:9060 See related Ensembl:ENSG00000187091 MIM:602142; AllianceGenome:HGNC:9060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDNC3; PLC-III Summary This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Broad expression in testis (RPKM 17.3), esophagus (RPKM 7.7) and 24 other tissues See more Orthologs mouse all