NEK4, Official Symbol NEK4provided by HGNC Official Full Name NIMA related kinase 4provided by HGNC Primary source HGNC:HGNC:11399 See related Ensembl:ENSG00000114904 MIM:601959; AllianceGenome:HGNC:11399 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRK2; STK2; pp12301 Summary The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017] Expression Broad expression in testis (RPKM 13.9), thyroid (RPKM 5.5) and 25 other tissues See more Orthologs mouse all