LTBP4, Official Symbol LTBP4provided by HGNC Official Full Name latent transforming growth factor beta binding protein 4provided by HGNC Primary source HGNC:HGNC:6717 See related Ensembl:ENSG00000090006 MIM:604710; AllianceGenome:HGNC:6717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARCL1C; LTBP-4; LTBP4L; LTBP4S Summary The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] Expression Broad expression in prostate (RPKM 61.4), endometrium (RPKM 53.8) and 22 other tissues See more Orthologs mouse all