MEPE, Official Symbol MEPEprovided by HGNC Official Full Name matrix extracellular phosphoglycoproteinprovided by HGNC Primary source HGNC:HGNC:13361 See related Ensembl:ENSG00000152595 MIM:605912; AllianceGenome:HGNC:13361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OF45 Summary This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Restricted expression toward brain (RPKM 2.2) See more Orthologs mouse all