MAP3K8, Official Symbol MAP3K8provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 8provided by HGNC Primary source HGNC:HGNC:6860 See related Ensembl:ENSG00000107968 MIM:191195; AllianceGenome:HGNC:6860 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT Summary This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Expression Broad expression in bone marrow (RPKM 18.4), appendix (RPKM 6.8) and 17 other tissues See more Orthologs mouse all