GTF2B, Official Symbol GTF2Bprovided by HGNC Official Full Name general transcription factor IIBprovided by HGNC Primary source HGNC:HGNC:4648 See related Ensembl:ENSG00000137947 MIM:189963; AllianceGenome:HGNC:4648 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TF2B; TFIIB Summary This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 18.5), gall bladder (RPKM 11.2) and 25 other tissues See more Orthologs mouse all