PLCG2, Official Symbol PLCG2provided by HGNC Official Full Name phospholipase C gamma 2provided by HGNC Primary source HGNC:HGNC:9066 See related Ensembl:ENSG00000197943 MIM:600220; AllianceGenome:HGNC:9066 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCAS3; APLAID; PLC-IV; PLC-gamma-2 Summary The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014] Expression Broad expression in lymph node (RPKM 20.0), spleen (RPKM 12.3) and 21 other tissues See more Orthologs mouse all