ALOX12, Official Symbol ALOX12provided by HGNC Official Full Name arachidonate 12-lipoxygenase, 12S typeprovided by HGNC Primary source HGNC:HGNC:429 See related Ensembl:ENSG00000108839 MIM:152391; AllianceGenome:HGNC:429 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOG12; 12-LOX; 12S-LOX Summary This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017] Expression Broad expression in esophagus (RPKM 11.1), skin (RPKM 5.2) and 15 other tissues See more Orthologs mouse all