PEMT, Official Symbol PEMTprovided by HGNC Official Full Name phosphatidylethanolamine N-methyltransferaseprovided by HGNC Primary source HGNC:HGNC:8830 See related Ensembl:ENSG00000133027 MIM:602391; AllianceGenome:HGNC:8830 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLMT; PNMT; PEAMT; PEMPT; PEMT2 Summary Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012] Expression Broad expression in liver (RPKM 29.5), fat (RPKM 10.2) and 25 other tissues See more Orthologs mouse all