UNC80, Official Symbol UNC80provided by HGNC Official Full Name unc-80 homolog, NALCN channel complex subunitprovided by HGNC Primary source HGNC:HGNC:26582 See related Ensembl:ENSG00000144406 MIM:612636; AllianceGenome:HGNC:26582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC-80; C2orf21 Summary The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016] Expression Biased expression in brain (RPKM 5.6), adrenal (RPKM 2.1) and 3 other tissues See more Orthologs mouse all