TIMP1, Official Symbol TIMP1provided by HGNC Official Full Name TIMP metallopeptidase inhibitor 1provided by HGNC Primary source HGNC:HGNC:11820 See related Ensembl:ENSG00000102265 MIM:305370; AllianceGenome:HGNC:11820 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPA; EPO; HCI; CLGI; TIMP; TIMP-1 Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 344.6), gall bladder (RPKM 211.2) and 15 other tissues See more Orthologs mouse all