EHD2, Official Symbol EHD2provided by HGNC Official Full Name EH domain containing 2provided by HGNC Primary source HGNC:HGNC:3243 See related Ensembl:ENSG00000024422 MIM:605890; AllianceGenome:HGNC:3243 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAST2 Summary This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 140.8), lung (RPKM 41.0) and 18 other tissues See more Orthologs mouse all