RSPO2, Official Symbol RSPO2provided by HGNC Official Full Name R-spondin 2provided by HGNC Primary source HGNC:HGNC:28583 See related Ensembl:ENSG00000147655 MIM:610575; AllianceGenome:HGNC:28583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHRRD; TETAMS2; CRISTIN2 Summary This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in brain (RPKM 3.8), placenta (RPKM 3.6) and 11 other tissues See more Orthologs mouse all