DMAP1, Official Symbol DMAP1provided by HGNC Official Full Name DNA methyltransferase 1 associated protein 1provided by HGNC Primary source HGNC:HGNC:18291 See related Ensembl:ENSG00000178028 MIM:605077; AllianceGenome:HGNC:18291 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1 Summary This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 14.7), ovary (RPKM 11.2) and 25 other tissues See more Orthologs mouse all