NR1H4, Official Symbol NR1H4provided by HGNC Official Full Name nuclear receptor subfamily 1 group H member 4provided by HGNC Primary source HGNC:HGNC:7967 See related Ensembl:ENSG00000012504 MIM:603826; AllianceGenome:HGNC:7967 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAR; FXR; HRR1; HRR-1; PFIC5; RIP14 Summary This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016] Expression Biased expression in liver (RPKM 14.7), small intestine (RPKM 8.3) and 6 other tissues See more Orthologs mouse all