PIGP, Official Symbol PIGPprovided by HGNC Official Full Name phosphatidylinositol glycan anchor biosynthesis class Pprovided by HGNC Primary source HGNC:HGNC:3046 See related Ensembl:ENSG00000185808 MIM:605938; AllianceGenome:HGNC:3046 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCRC; DSRC; DEE55; DSCR5; PIG-P; DCRC-S; EIEE55 Summary This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in fat (RPKM 11.1), adrenal (RPKM 10.6) and 25 other tissues See more Orthologs mouse all