CDK2AP1, Official Symbol CDK2AP1provided by HGNC Official Full Name cyclin dependent kinase 2 associated protein 1provided by HGNC Primary source HGNC:HGNC:14002 See related Ensembl:ENSG00000111328 MIM:602198; AllianceGenome:HGNC:14002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOC1; ST19; DORC1; doc-1; p12DOC-1 Summary The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in brain (RPKM 57.9), endometrium (RPKM 35.8) and 25 other tissues See more Orthologs mouse all