AICDA, Official Symbol AICDAprovided by HGNC Official Full Name activation induced cytidine deaminaseprovided by HGNC Primary source HGNC:HGNC:13203 See related Ensembl:ENSG00000111732 MIM:605257; AllianceGenome:HGNC:13203 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AID; ARP2; CDA2; HIGM2; HEL-S-284 Summary This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020] Expression Biased expression in lymph node (RPKM 7.1) and appendix (RPKM 1.7) See more Orthologs mouse all