UBE2H, Official Symbol UBE2Hprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Hprovided by HGNC Primary source HGNC:HGNC:12484 See related Ensembl:ENSG00000186591 MIM:601082; AllianceGenome:HGNC:12484 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GID3; UBC8; UBCH; UBCH2; E2-20K Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in heart (RPKM 38.0), adrenal (RPKM 36.4) and 25 other tissues See more Orthologs mouse all