TMBIM6, Official Symbol TMBIM6provided by HGNC Official Full Name transmembrane BAX inhibitor motif containing 6provided by HGNC Primary source HGNC:HGNC:11723 See related Ensembl:ENSG00000139644 MIM:600748; AllianceGenome:HGNC:11723 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BI-1; TEGT; BAXI1 Summary Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process; negative regulation of intrinsic apoptotic signaling pathway; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 392.9), liver (RPKM 352.7) and 25 other tissues See more Orthologs mouse all