SERPINB4, Official Symbol SERPINB4provided by HGNC Official Full Name serpin family B member 4provided by HGNC Primary source HGNC:HGNC:10570 See related Ensembl:ENSG00000206073 MIM:600518; AllianceGenome:HGNC:10570 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PI11; SCCA1; SCCA2; LEUPIN; SCCA-2 Summary The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017] Expression Biased expression in esophagus (RPKM 63.1), urinary bladder (RPKM 11.6) and 1 other tissue See more Orthologs all