KDM4A, Official Symbol KDM4Aprovided by HGNC Official Full Name lysine demethylase 4Aprovided by HGNC Primary source HGNC:HGNC:22978 See related Ensembl:ENSG00000066135 MIM:609764; AllianceGenome:HGNC:22978 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JMJD2; JHDM3A; JMJD2A; TDRD14A Summary This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] Expression Ubiquitous expression in duodenum (RPKM 11.5), thyroid (RPKM 10.1) and 25 other tissues See more Orthologs mouse all