ITGAM, Official Symbol ITGAMprovided by HGNC Official Full Name integrin subunit alpha Mprovided by HGNC Primary source HGNC:HGNC:6149 See related Ensembl:ENSG00000169896 MIM:120980; AllianceGenome:HGNC:6149 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6 Summary This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Biased expression in bone marrow (RPKM 72.3), appendix (RPKM 14.6) and 6 other tissues See more Orthologs mouse all