BACE1, Official Symbol BACE1provided by HGNC Official Full Name beta-secretase 1provided by HGNC Primary source HGNC:HGNC:933 See related Ensembl:ENSG00000186318 MIM:604252; AllianceGenome:HGNC:933 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASP2; BACE; HSPC104 Summary This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in pancreas (RPKM 33.5), brain (RPKM 30.2) and 24 other tissues See more Orthologs mouse all