PIK3R3, Official Symbol PIK3R3provided by HGNC Official Full Name phosphoinositide-3-kinase regulatory subunit 3provided by HGNC Primary source HGNC:HGNC:8981 See related Ensembl:ENSG00000117461 MIM:606076; AllianceGenome:HGNC:8981 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p55; p55PIK; p55-GAMMA Summary Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016] Expression Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues See more Orthologs mouse all