CBX2, Official Symbol CBX2provided by HGNC Official Full Name chromobox 2provided by HGNC Primary source HGNC:HGNC:1552 See related Ensembl:ENSG00000173894 MIM:602770; AllianceGenome:HGNC:1552 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M33; CDCA6; SRXY5 Summary This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010] Expression Biased expression in testis (RPKM 5.1), placenta (RPKM 1.0) and 13 other tissues See more Orthologs mouse all