CYP3A5, Official Symbol CYP3A5provided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 5provided by HGNC Primary source HGNC:HGNC:2638 See related Ensembl:ENSG00000106258 MIM:605325; AllianceGenome:HGNC:2638 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP35; PCN3; CYPIIIA5; P450PCN3 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Biased expression in small intestine (RPKM 67.4), duodenum (RPKM 57.9) and 7 other tissues See more Orthologs all