LCK, Official Symbol LCKprovided by HGNC Official Full Name LCK proto-oncogene, Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:6524 See related Ensembl:ENSG00000182866 MIM:153390; AllianceGenome:HGNC:6524 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSK; YT16; IMD22; p56lck; pp58lck Summary This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016] Expression Biased expression in lymph node (RPKM 46.5), appendix (RPKM 22.7) and 9 other tissues See more Orthologs mouse all