LGI1, Official Symbol LGI1provided by HGNC Official Full Name leucine rich glioma inactivated 1provided by HGNC Primary source HGNC:HGNC:6572 See related Ensembl:ENSG00000108231 MIM:604619; AllianceGenome:HGNC:6572 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN Summary This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Biased expression in brain (RPKM 13.8), esophagus (RPKM 1.7) and 3 other tissues See more Orthologs mouse all