ITPKB, Official Symbol ITPKBprovided by HGNC Official Full Name inositol-trisphosphate 3-kinase Bprovided by HGNC Primary source HGNC:HGNC:6179 See related Ensembl:ENSG00000143772 MIM:147522; AllianceGenome:HGNC:6179 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB Summary The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues See more Orthologs mouse all