DTNA, Official Symbol DTNAprovided by HGNC Official Full Name dystrobrevin alphaprovided by HGNC Primary source HGNC:HGNC:3057 See related Ensembl:ENSG00000134769 MIM:601239; AllianceGenome:HGNC:3057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DTN; DRP3; DTN-A; LVNC1; D18S892E Summary The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 27.5), heart (RPKM 10.7) and 10 other tissues See more Orthologs mouse all