ITPR3, Official Symbol ITPR3provided by HGNC Official Full Name inositol 1,4,5-trisphosphate receptor type 3provided by HGNC Primary source HGNC:HGNC:6182 See related Ensembl:ENSG00000096433 MIM:147267; AllianceGenome:HGNC:6182 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IP3R; CMT1J; IP3R3 Summary This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010] Expression Broad expression in thyroid (RPKM 29.7), skin (RPKM 28.2) and 22 other tissues See more Orthologs mouse all