SPTLC3, Official Symbol SPTLC3provided by HGNC Official Full Name serine palmitoyltransferase long chain base subunit 3provided by HGNC Primary source HGNC:HGNC:16253 See related Ensembl:ENSG00000172296 MIM:611120; AllianceGenome:HGNC:16253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCB3; SPT3; LCB 3; LCB2B; SPT 3; hLCB2b; SPTLC2L; C20orf38; dJ718P11; dJ718P11.1 Summary This gene encodes a subunit of the serine palmitoyltransferase complex which catalyzes the rate-limiting step in sphingolipid biosynthesis. This subunit metabolizes lauroyl- and myristoyl-CoA and generates C14 and C16-sphingoid bases. [provided by RefSeq, Mar 2017] Expression Broad expression in placenta (RPKM 7.5), thyroid (RPKM 7.0) and 22 other tissues See more Orthologs mouse all