TRAF5, Official Symbol TRAF5provided by HGNC Official Full Name TNF receptor associated factor 5provided by HGNC Primary source HGNC:HGNC:12035 See related Ensembl:ENSG00000082512 MIM:602356; AllianceGenome:HGNC:12035 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF84; MGC:39780 Summary The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Broad expression in lymph node (RPKM 13.9), appendix (RPKM 8.7) and 24 other tissues See more Orthologs mouse all