USF1, Official Symbol USF1provided by HGNC Official Full Name upstream transcription factor 1provided by HGNC Primary source HGNC:HGNC:12593 See related Ensembl:ENSG00000158773 MIM:191523; AllianceGenome:HGNC:12593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11 Summary This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] Expression Ubiquitous expression in spleen (RPKM 29.9), lymph node (RPKM 25.8) and 25 other tissues See more Orthologs mouse all