ATF2, Official Symbol ATF2provided by HGNC Official Full Name activating transcription factor 2provided by HGNC Primary source HGNC:HGNC:784 See related Ensembl:ENSG00000115966 MIM:123811; AllianceGenome:HGNC:784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HB16; CREB2; TREB7; CREB-2; CRE-BP1 Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues See more Orthologs mouse all