ALDH8A1, Official Symbol ALDH8A1provided by HGNC Official Full Name aldehyde dehydrogenase 8 family member A1provided by HGNC Primary source HGNC:HGNC:15471 See related Ensembl:ENSG00000118514 MIM:606467; AllianceGenome:HGNC:15471 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALDH12; DJ352A20.2 Summary This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018] Expression Biased expression in liver (RPKM 60.7) and kidney (RPKM 37.6) See more Orthologs mouse all