DENND1C, Official Symbol DENND1Cprovided by HGNC Official Full Name DENN domain containing 1Cprovided by HGNC Primary source HGNC:HGNC:26225 See related Ensembl:ENSG00000205744 MIM:613634; AllianceGenome:HGNC:26225 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM31C Summary The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017] Expression Broad expression in lymph node (RPKM 22.3), spleen (RPKM 19.6) and 19 other tissues See more Orthologs mouse all