DERL3, Official Symbol DERL3provided by HGNC Official Full Name derlin 3provided by HGNC Primary source HGNC:HGNC:14236 See related Ensembl:ENSG00000099958 MIM:610305; AllianceGenome:HGNC:14236 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IZP6; LLN2; C22orf14; derlin-3 Summary The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] Expression Broad expression in stomach (RPKM 12.2), duodenum (RPKM 11.1) and 22 other tissues See more Orthologs mouse all