SIAH2, Official Symbol SIAH2provided by HGNC Official Full Name siah E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:10858 See related Ensembl:ENSG00000181788 MIM:602213; AllianceGenome:HGNC:10858 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hSiah2 Summary This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 42.6), placenta (RPKM 22.5) and 24 other tissues See more Orthologs mouse all