SERPINA1, Official Symbol SERPINA1provided by HGNC Official Full Name serpin family A member 1provided by HGNC Primary source HGNC:HGNC:8941 See related Ensembl:ENSG00000197249 MIM:107400; AllianceGenome:HGNC:8941 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PI; A1A; AAT; PI1; A1AT; nNIF; PRO2275; alpha1AT Summary The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020] Expression Biased expression in liver (RPKM 3603.5) and small intestine (RPKM 158.3) See more Orthologs all