STAM, Official Symbol STAMprovided by HGNC Official Full Name signal transducing adaptor moleculeprovided by HGNC Primary source HGNC:HGNC:11357 See related Ensembl:ENSG00000136738 MIM:601899; AllianceGenome:HGNC:11357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STAM1; STAM-1 Summary This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues See more Orthologs mouse all