EDEM3, Official Symbol EDEM3provided by HGNC Official Full Name ER degradation enhancing alpha-mannosidase like protein 3provided by HGNC Primary source HGNC:HGNC:16787 See related Ensembl:ENSG00000116406 MIM:610214; AllianceGenome:HGNC:16787 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDG2V; C1orf22 Summary Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in stomach (RPKM 15.9), colon (RPKM 13.5) and 25 other tissues See more Orthologs mouse all