STK11, Official Symbol STK11provided by HGNC Official Full Name serine/threonine kinase 11provided by HGNC Primary source HGNC:HGNC:11389 See related Ensembl:ENSG00000118046 MIM:602216; AllianceGenome:HGNC:11389 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PJS; LKB1; hLKB1 Summary The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022] Expression Broad expression in testis (RPKM 28.3), spleen (RPKM 10.4) and 25 other tissues See more Orthologs mouse all