CALCA, Official Symbol CALCAprovided by HGNC Official Full Name calcitonin related polypeptide alphaprovided by HGNC Primary source HGNC:HGNC:1437 See related Ensembl:ENSG00000110680 MIM:114130; AllianceGenome:HGNC:1437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I; CGRP-alpha Summary This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014] Expression Restricted expression toward thyroid (RPKM 13.7) See more Orthologs mouse all