ADH4, Official Symbol ADH4provided by HGNC Official Full Name alcohol dehydrogenase 4 (class II), pi polypeptideprovided by HGNC Primary source HGNC:HGNC:252 See related Ensembl:ENSG00000198099 MIM:103740; AllianceGenome:HGNC:252 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH-2; HEL-S-4 Summary This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 940.8) See more Orthologs mouse all