ECSCR, Official Symbol ECSCRprovided by HGNC Official Full Name endothelial cell surface expressed chemotaxis and apoptosis regulatorprovided by HGNC Primary source HGNC:HGNC:35454 See related Ensembl:ENSG00000249751 MIM:615736; AllianceGenome:HGNC:35454 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARIA; ECSM2 Summary The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Annotation information Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_029289.12 and the 3' end was annotated on NT_034772.7 in NCBI's Homo sapiens Annotation Release 106. [17 Jun 2014] Annotation category: suggests misassembly Expression Broad expression in placenta (RPKM 24.9), lung (RPKM 23.6) and 22 other tissues See more Orthologs mouse all