SUPT16H, Official Symbol SUPT16Hprovided by HGNC Official Full Name SPT16 homolog, facilitates chromatin remodeling subunitprovided by HGNC Primary source HGNC:HGNC:11465 See related Ensembl:ENSG00000092201 MIM:605012; AllianceGenome:HGNC:11465 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC68; SPT16; NEDDFAC; FACTP140; SPT16/CDC68 Summary Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009] Expression Ubiquitous expression in testis (RPKM 30.8), lymph node (RPKM 27.6) and 25 other tissues See more Orthologs mouse all