IFT74, Official Symbol IFT74provided by HGNC Official Full Name intraflagellar transport 74provided by HGNC Primary source HGNC:HGNC:21424 See related Ensembl:ENSG00000096872 MIM:608040; AllianceGenome:HGNC:21424 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMG1; BBS22; CCDC2; CMG-1; JBTS40; SPGF58 Summary This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017] Expression Broad expression in testis (RPKM 6.8), thyroid (RPKM 3.2) and 24 other tissues See more Orthologs mouse all