SPINK9, Official Symbol SPINK9provided by HGNC Official Full Name serine peptidase inhibitor Kazal type 9provided by HGNC Primary source HGNC:HGNC:32951 See related Ensembl:ENSG00000204909 MIM:613511; AllianceGenome:HGNC:32951 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEKTI2 Summary The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015] Expression Low expression observed in reference dataset See more Orthologs all