TREM2, Official Symbol TREM2provided by HGNC Official Full Name triggering receptor expressed on myeloid cells 2provided by HGNC Primary source HGNC:HGNC:17761 See related Ensembl:ENSG00000095970 MIM:605086; AllianceGenome:HGNC:17761 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c Summary This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] Expression Broad expression in brain (RPKM 11.5), lung (RPKM 7.7) and 14 other tissues See more Orthologs mouse all