TCL1A, Official Symbol TCL1Aprovided by HGNC Official Full Name TCL1 family AKT coactivator Aprovided by HGNC Primary source HGNC:HGNC:11648 See related Ensembl:ENSG00000100721 MIM:186960; AllianceGenome:HGNC:11648 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCL1 Summary Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] Expression Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues See more Orthologs mouse all