MME, Official Symbol MMEprovided by HGNC Official Full Name membrane metalloendopeptidaseprovided by HGNC Primary source HGNC:HGNC:7154 See related Ensembl:ENSG00000196549 MIM:120520; AllianceGenome:HGNC:7154 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEP; SFE; CD10; CALLA; CMT2T; SCA43 Summary The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017] Expression Biased expression in duodenum (RPKM 88.5), kidney (RPKM 83.7) and 8 other tissues See more Orthologs mouse all