ISG20, Official Symbol ISG20provided by HGNC Official Full Name interferon stimulated exonuclease gene 20provided by HGNC Primary source HGNC:HGNC:6130 See related Ensembl:ENSG00000172183 MIM:604533; AllianceGenome:HGNC:6130 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD25; HEM45 Summary Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 12.2), spleen (RPKM 8.7) and 13 other tissues See more Orthologs mouse all