MED26, Official Symbol MED26provided by HGNC Official Full Name mediator complex subunit 26provided by HGNC Primary source HGNC:HGNC:2376 See related Ensembl:ENSG00000105085 MIM:605043; AllianceGenome:HGNC:2376 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRSP7; CRSP70 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 18.2), bone marrow (RPKM 6.2) and 23 other tissues See more Orthologs mouse all