ASXL2, Official Symbol ASXL2provided by HGNC Official Full Name ASXL transcriptional regulator 2provided by HGNC Primary source HGNC:HGNC:23805 See related Ensembl:ENSG00000143970 MIM:612991; AllianceGenome:HGNC:23805 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASXH2; SHAPNS Summary This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017] Expression Ubiquitous expression in testis (RPKM 5.8), thyroid (RPKM 4.6) and 25 other tissues See more Orthologs mouse all