PLPP3, Official Symbol PLPP3provided by HGNC Official Full Name phospholipid phosphatase 3provided by HGNC Primary source HGNC:HGNC:9229 See related Ensembl:ENSG00000162407 MIM:607125; AllianceGenome:HGNC:9229 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPP3; VCIP; Dri42; PAP2B; PPAP2B Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010] Expression Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues See more Orthologs mouse all