SCN7A, Official Symbol SCN7Aprovided by HGNC Official Full Name sodium voltage-gated channel alpha subunit 7provided by HGNC Primary source HGNC:HGNC:10594 See related Ensembl:ENSG00000136546 MIM:182392; AllianceGenome:HGNC:10594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NaG; SCN6A; Nav2.1; Nav2.2 Summary This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011] Expression Broad expression in ovary (RPKM 21.8), lung (RPKM 14.7) and 15 other tissues See more Orthologs mouse all