NGLY1, Official Symbol NGLY1provided by HGNC Official Full Name N-glycanase 1provided by HGNC Primary source HGNC:HGNC:17646 See related Ensembl:ENSG00000151092 MIM:610661; AllianceGenome:HGNC:17646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDDG; PNG1; CDG1V; PNG-1; PNGase Summary This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009] Expression Broad expression in testis (RPKM 28.0), lymph node (RPKM 11.3) and 25 other tissues See more Orthologs mouse all