DNAJC2, Official Symbol DNAJC2provided by HGNC Official Full Name DnaJ heat shock protein family (Hsp40) member C2provided by HGNC Primary source HGNC:HGNC:13192 See related Ensembl:ENSG00000105821 MIM:605502; AllianceGenome:HGNC:13192 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZRF1; ZUO1; MPP11; MPHOSPH11 Summary This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 19.0), testis (RPKM 17.8) and 25 other tissues See more Orthologs mouse all