HIF1AN, Official Symbol HIF1ANprovided by HGNC Official Full Name hypoxia inducible factor 1 subunit alpha inhibitorprovided by HGNC Primary source HGNC:HGNC:17113 See related Ensembl:ENSG00000166135 MIM:606615; AllianceGenome:HGNC:17113 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIH1 Summary Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 12.2), skin (RPKM 8.6) and 25 other tissues See more Orthologs mouse all