KATNA1, Official Symbol KATNA1provided by HGNC Official Full Name katanin catalytic subunit A1provided by HGNC Primary source HGNC:HGNC:6216 See related Ensembl:ENSG00000186625 MIM:606696; AllianceGenome:HGNC:6216 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011] Expression Broad expression in testis (RPKM 18.8), ovary (RPKM 7.2) and 24 other tissues See more Orthologs mouse all