ECT2, Official Symbol ECT2provided by HGNC Official Full Name epithelial cell transforming 2provided by HGNC Primary source HGNC:HGNC:3155 See related Ensembl:ENSG00000114346 MIM:600586; AllianceGenome:HGNC:3155 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHGEF31 Summary The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017] Expression Broad expression in testis (RPKM 6.4), colon (RPKM 5.0) and 24 other tissues See more Orthologs mouse all