BMPR2, Official Symbol BMPR2provided by HGNC Official Full Name bone morphogenetic protein receptor type 2provided by HGNC Primary source HGNC:HGNC:1078 See related Ensembl:ENSG00000204217 MIM:600799; AllianceGenome:HGNC:1078 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II Summary This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020] Expression Ubiquitous expression in lung (RPKM 16.2), brain (RPKM 15.1) and 24 other tissues See more Orthologs mouse all