PADI1, Official Symbol PADI1provided by HGNC Official Full Name peptidyl arginine deiminase 1provided by HGNC Primary source HGNC:HGNC:18367 See related Ensembl:ENSG00000142623 MIM:607934; AllianceGenome:HGNC:18367 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDI; PAD1; PDI1; HPAD10 Summary This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 30.8) and skin (RPKM 4.2) See more Orthologs mouse all