RBBP8, Official Symbol RBBP8provided by HGNC Official Full Name RB binding protein 8, endonucleaseprovided by HGNC Primary source HGNC:HGNC:9891 See related Ensembl:ENSG00000101773 MIM:604124; AllianceGenome:HGNC:9891 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIM; COM1; CTIP; JWDS; SAE2; JAWAD; SCKL2 Summary The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 11.3), kidney (RPKM 6.6) and 25 other tissues See more Orthologs mouse all