PARP4, Official Symbol PARP4provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 4provided by HGNC Primary source HGNC:HGNC:271 See related Ensembl:ENSG00000102699 MIM:607519; AllianceGenome:HGNC:271 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1 Summary This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 22.5), small intestine (RPKM 20.2) and 25 other tissues See more Orthologs mouse all