PAK2, Official Symbol PAK2provided by HGNC Official Full Name p21 (RAC1) activated kinase 2provided by HGNC Primary source HGNC:HGNC:8591 See related Ensembl:ENSG00000180370 MIM:605022; AllianceGenome:HGNC:8591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KNO2; PAK65; PAKgamma Summary The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 22.2), appendix (RPKM 21.0) and 25 other tissues See more Orthologs mouse all