TMEM158, Official Symbol TMEM158provided by HGNC Official Full Name transmembrane protein 158provided by HGNC Primary source HGNC:HGNC:30293 See related Ensembl:ENSG00000249992 MIM:620257; AllianceGenome:HGNC:30293 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BBP; RIS1; p40BBP Summary Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Orthologs mouse all