PTGS1, Official Symbol PTGS1provided by HGNC Official Full Name prostaglandin-endoperoxide synthase 1provided by HGNC Primary source HGNC:HGNC:9604 See related Ensembl:ENSG00000095303 MIM:176805; AllianceGenome:HGNC:9604 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1 Summary This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021] Expression Biased expression in skin (RPKM 36.8), esophagus (RPKM 21.4) and 12 other tissues See more Orthologs mouse all