SPI1, Official Symbol SPI1provided by HGNC Official Full Name Spi-1 proto-oncogeneprovided by HGNC Primary source HGNC:HGNC:11241 See related Ensembl:ENSG00000066336 MIM:165170; AllianceGenome:HGNC:11241 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OF; PU.1; AGM10; SFPI1; SPI-1; SPI-A Summary This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 36.5), appendix (RPKM 27.0) and 18 other tissues See more Orthologs mouse all