FLI1, Official Symbol FLI1provided by HGNC Official Full Name Fli-1 proto-oncogene, ETS transcription factorprovided by HGNC Primary source HGNC:HGNC:3749 See related Ensembl:ENSG00000151702 MIM:193067; AllianceGenome:HGNC:3749 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EWSR2; FLI-1; SIC-1; BDPLT21 Summary This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Annotation information Note: FLI1 (Gene ID: 2313) and FLII (Gene ID: 2314) share the FLI1 symbol/alias in common. FLI1 is a widely used alternative name for FLII, actin remodeling protein (FLII), which can be confused with the official symbol for FLI1 (Fli-1 proto-oncogene, ETS transcription factor, GeneID 2313). [01 Jun 2018] Expression Broad expression in spleen (RPKM 33.9), lymph node (RPKM 17.6) and 20 other tissues See more Orthologs mouse all