SCRIB, Official Symbol SCRIBprovided by HGNC Official Full Name scribble planar cell polarity proteinprovided by HGNC Primary source HGNC:HGNC:30377 See related Ensembl:ENSG00000180900 MIM:607733; AllianceGenome:HGNC:30377 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRIB1; SCRB1; SCRIB1; Vartul; oSCRIB Summary This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in colon (RPKM 9.3), skin (RPKM 9.0) and 25 other tissues See more Orthologs mouse all