CHRM2, Official Symbol CHRM2provided by HGNC Official Full Name cholinergic receptor muscarinic 2provided by HGNC Primary source HGNC:HGNC:1951 See related Ensembl:ENSG00000181072 MIM:118493; AllianceGenome:HGNC:1951 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HM2 Summary The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 10.8), gall bladder (RPKM 5.9) and 3 other tissues See more Orthologs mouse all