ITGA5, Official Symbol ITGA5provided by HGNC Official Full Name integrin subunit alpha 5provided by HGNC Primary source HGNC:HGNC:6141 See related Ensembl:ENSG00000161638 MIM:135620; AllianceGenome:HGNC:6141 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FNRA; CD49e; VLA-5; VLA5A Summary The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] Expression Broad expression in appendix (RPKM 85.6), urinary bladder (RPKM 54.1) and 19 other tissues See more Orthologs mouse all