AADAT, Official Symbol AADATprovided by HGNC Official Full Name aminoadipate aminotransferaseprovided by HGNC Primary source HGNC:HGNC:17929 See related Ensembl:ENSG00000109576 MIM:611754; AllianceGenome:HGNC:17929 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAT2; KATII; KYAT2 Summary This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Broad expression in liver (RPKM 11.4), prostate (RPKM 6.3) and 19 other tissues See more Orthologs mouse all