AKR1B1, Official Symbol AKR1B1provided by HGNC Official Full Name aldo-keto reductase family 1 member Bprovided by HGNC Primary source HGNC:HGNC:381 See related Ensembl:ENSG00000085662 MIM:103880; AllianceGenome:HGNC:381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AR; ADR; ALR2; ALDR1 Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009] Expression Biased expression in adrenal (RPKM 1087.3), placenta (RPKM 120.6) and 2 other tissues See more Orthologs mouse all