ORC3, Official Symbol ORC3provided by HGNC Official Full Name origin recognition complex subunit 3provided by HGNC Primary source HGNC:HGNC:8489 See related Ensembl:ENSG00000135336 MIM:604972; AllianceGenome:HGNC:8489 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAT; ORC3L; LATHEO Summary The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 9.4), adrenal (RPKM 6.1) and 25 other tissues See more Orthologs mouse all