PRG4, Official Symbol PRG4provided by HGNC Official Full Name proteoglycan 4provided by HGNC Primary source HGNC:HGNC:9364 See related Ensembl:ENSG00000116690 MIM:604283; AllianceGenome:HGNC:9364 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSF; SZP; CACP; HAPO; JCAP Summary The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Biased expression in liver (RPKM 61.2), fat (RPKM 6.6) and 1 other tissue See more Orthologs mouse all