KCNN2, Official Symbol KCNN2provided by HGNC Official Full Name potassium calcium-activated channel subfamily N member 2provided by HGNC Primary source HGNC:HGNC:6291 See related Ensembl:ENSG00000080709 MIM:605879; AllianceGenome:HGNC:6291 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK2; hSK2; DYT34; SKCA2; KCa2.2; NEDMAB; SKCa 2 Summary Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] Expression Biased expression in adrenal (RPKM 4.9), liver (RPKM 3.5) and 8 other tissues See more Orthologs mouse all