OLR1, Official Symbol OLR1provided by HGNC Official Full Name oxidized low density lipoprotein receptor 1provided by HGNC Primary source HGNC:HGNC:8133 See related Ensembl:ENSG00000173391 MIM:602601; AllianceGenome:HGNC:8133 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOX1; LOXIN; SLOX1; CLEC8A; SCARE1 Summary This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] Expression Biased expression in placenta (RPKM 50.3), lung (RPKM 32.5) and 5 other tissues See more Orthologs mouse all