SERPINI1, Official Symbol SERPINI1provided by HGNC Official Full Name serpin family I member 1provided by HGNC Primary source HGNC:HGNC:8943 See related Ensembl:ENSG00000163536 MIM:602445; AllianceGenome:HGNC:8943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PI12; HNS-S1; HNS-S2; neuroserpin Summary This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 83.3), testis (RPKM 7.2) and 3 other tissues See more Orthologs mouse all