RUFY3, Official Symbol RUFY3provided by HGNC Official Full Name RUN and FYVE domain containing 3provided by HGNC Primary source HGNC:HGNC:30285 See related Ensembl:ENSG00000018189 MIM:611194; AllianceGenome:HGNC:30285 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIPX; SINGAR1; ZFYVE30 Summary This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 10.8) and 24 other tissues See more Orthologs mouse all