CD3D, Official Symbol CD3Dprovided by HGNC Official Full Name CD3 delta subunit of T-cell receptor complexprovided by HGNC Primary source HGNC:HGNC:1673 See related Ensembl:ENSG00000167286 MIM:186790; AllianceGenome:HGNC:1673 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3D; IMD19; CD3DELTA; CD3-DELTA Summary The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] Expression Biased expression in lymph node (RPKM 30.2), appendix (RPKM 14.7) and 9 other tissues See more Orthologs mouse all