WFDC3, Official Symbol WFDC3provided by HGNC Official Full Name WAP four-disulfide core domain 3provided by HGNC Primary source HGNC:HGNC:15957 See related Ensembl:ENSG00000124116 AllianceGenome:HGNC:15957 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP14; dJ447F3.3 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 19.8) See more Orthologs mouse all