TCP1, Official Symbol TCP1provided by HGNC Official Full Name t-complex 1provided by HGNC Primary source HGNC:HGNC:11655 See related Ensembl:ENSG00000120438 MIM:186980; AllianceGenome:HGNC:11655 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in testis (RPKM 91.3), brain (RPKM 50.5) and 25 other tissues See more Orthologs mouse all