YWHAQ, Official Symbol YWHAQprovided by HGNC Official Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaprovided by HGNC Primary source HGNC:HGNC:12854 See related Ensembl:ENSG00000134308 MIM:609009; AllianceGenome:HGNC:12854 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1C5; HS1; 14-3-3 Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 160.3), endometrium (RPKM 117.5) and 25 other tissues See more Orthologs mouse all