SAT1, Official Symbol SAT1provided by HGNC Official Full Name spermidine/spermine N1-acetyltransferase 1provided by HGNC Primary source HGNC:HGNC:10540 See related Ensembl:ENSG00000130066 MIM:313020; AllianceGenome:HGNC:10540 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1 Summary The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009] Expression Ubiquitous expression in bone marrow (RPKM 336.5), thyroid (RPKM 226.9) and 24 other tissues See more Orthologs mouse all