ULBP1, Official Symbol ULBP1provided by HGNC Official Full Name UL16 binding protein 1provided by HGNC Primary source HGNC:HGNC:14893 See related Ensembl:ENSG00000111981 MIM:605697; AllianceGenome:HGNC:14893 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2DL-1; RAET1I; NKG2DL1 Summary The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Biased expression in testis (RPKM 1.6), lung (RPKM 0.5) and 3 other tissues See more Orthologs mouse all