DPM2, Official Symbol DPM2provided by HGNC Official Full Name dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by HGNC Primary source HGNC:HGNC:3006 See related Ensembl:ENSG00000136908 MIM:603564; AllianceGenome:HGNC:3006 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDG1U Summary Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in stomach (RPKM 13.1), thyroid (RPKM 12.2) and 25 other tissues See more Orthologs mouse all