BDKRB2, Official Symbol BDKRB2provided by HGNC Official Full Name bradykinin receptor B2provided by HGNC Primary source HGNC:HGNC:1030 See related Ensembl:ENSG00000168398 MIM:113503; AllianceGenome:HGNC:1030 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B2R; BK2; BK-2; BKR2; BRB2 Summary This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020] Expression Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues See more Orthologs mouse all