FLG, Official Symbol FLGprovided by HGNC Official Full Name filaggrinprovided by HGNC Primary source HGNC:HGNC:3748 See related Ensembl:ENSG00000143631 MIM:135940; AllianceGenome:HGNC:3748 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLG1; ATOD2; FLG-1 Summary The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009] Expression Restricted expression toward skin (RPKM 454.2) See more Orthologs mouse all