H2BC12, Official Symbol H2BC12provided by HGNC Official Full Name H2B clustered histone 12provided by HGNC Primary source HGNC:HGNC:13954 See related Ensembl:ENSG00000197903 MIM:615045; AllianceGenome:HGNC:13954 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H2BK; H2B/S; H2BFT; H2BFAiii; HIST1H2BK Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in prostate (RPKM 42.3), testis (RPKM 29.8) and 25 other tissues See more Orthologs all