GPBAR1, Official Symbol GPBAR1provided by HGNC Official Full Name G protein-coupled bile acid receptor 1provided by HGNC Primary source HGNC:HGNC:19680 See related Ensembl:ENSG00000179921 MIM:610147; AllianceGenome:HGNC:19680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BG37; TGR5; M-BAR; GPCR19; GPR131 Summary This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Biased expression in gall bladder (RPKM 4.9), fat (RPKM 2.9) and 11 other tissues See more Orthologs mouse all