PDE1B, Official Symbol PDE1Bprovided by HGNC Official Full Name phosphodiesterase 1Bprovided by HGNC Primary source HGNC:HGNC:8775 See related Ensembl:ENSG00000123360 MIM:171891; AllianceGenome:HGNC:8775 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDE1B1; PDES1B; HEL-S-79p Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Expression Broad expression in brain (RPKM 8.5), fat (RPKM 6.8) and 19 other tissues See more Orthologs mouse all