DHFR, Official Symbol DHFRprovided by HGNC Official Full Name dihydrofolate reductaseprovided by HGNC Primary source HGNC:HGNC:2861 See related Ensembl:ENSG00000228716 MIM:126060; AllianceGenome:HGNC:2861 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DYR; DHFR1; DHFRP1 Summary Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in fat (RPKM 21.2), lymph node (RPKM 18.2) and 24 other tissues See more Orthologs mouse all