TNS1, Official Symbol TNS1provided by HGNC Official Full Name tensin 1provided by HGNC Primary source HGNC:HGNC:11973 See related Ensembl:ENSG00000079308 MIM:600076; AllianceGenome:HGNC:11973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155 Summary The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Expression Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more Orthologs mouse all