PLA2G3, Official Symbol PLA2G3provided by HGNC Official Full Name phospholipase A2 group IIIprovided by HGNC Primary source HGNC:HGNC:17934 See related Ensembl:ENSG00000100078 MIM:611651; AllianceGenome:HGNC:17934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPLA2III; sPLA2-III; GIII-SPLA2 Summary This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014] Expression Biased expression in skin (RPKM 3.5), esophagus (RPKM 1.9) and 4 other tissues See more Orthologs mouse all