WDFY3, Official Symbol WDFY3provided by HGNC Official Full Name WD repeat and FYVE domain containing 3provided by HGNC Primary source HGNC:HGNC:20751 See related Ensembl:ENSG00000163625 MIM:617485; AllianceGenome:HGNC:20751 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALFY; BCHS; MCPH18; ZFYVE25 Summary This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010] Expression Ubiquitous expression in kidney (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues See more Orthologs mouse all