AGR3, Official Symbol AGR3provided by HGNC Official Full Name anterior gradient 3, protein disulphide isomerase family memberprovided by HGNC Primary source HGNC:HGNC:24167 See related Ensembl:ENSG00000173467 MIM:609482; AllianceGenome:HGNC:24167 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AG3; AG-3; HAG3; hAG-3; BCMP11; PDIA18 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016] Expression Biased expression in small intestine (RPKM 65.6), colon (RPKM 63.5) and 4 other tissues See more Orthologs mouse all