TRPC6, Official Symbol TRPC6provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 6provided by HGNC Primary source HGNC:HGNC:12338 See related Ensembl:ENSG00000137672 MIM:603652; AllianceGenome:HGNC:12338 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP6; FSGS2 Summary The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] Expression Broad expression in placenta (RPKM 7.7), lung (RPKM 7.3) and 18 other tissues See more Orthologs mouse all