DNA2, Official Symbol DNA2provided by HGNC Official Full Name DNA replication helicase/nuclease 2provided by HGNC Primary source HGNC:HGNC:2939 See related Ensembl:ENSG00000138346 MIM:601810; AllianceGenome:HGNC:2939 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DNA2L; hDNA2 Summary This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] Expression Broad expression in lymph node (RPKM 2.7), testis (RPKM 1.9) and 24 other tissues See more Orthologs mouse all