CXCR3, Official Symbol CXCR3provided by HGNC Official Full Name C-X-C motif chemokine receptor 3provided by HGNC Primary source HGNC:HGNC:4540 See related Ensembl:ENSG00000186810 MIM:300574; AllianceGenome:HGNC:4540 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R Summary This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011] Expression Biased expression in lymph node (RPKM 6.3), spleen (RPKM 3.4) and 13 other tissues See more Orthologs mouse all