SLC4A10, Official Symbol SLC4A10provided by HGNC Official Full Name solute carrier family 4 member 10provided by HGNC Primary source HGNC:HGNC:13811 See related Ensembl:ENSG00000144290 MIM:605556; AllianceGenome:HGNC:13811 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCBE; NBCn2 Summary This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] Expression Biased expression in brain (RPKM 21.0) and adrenal (RPKM 1.0) See more Orthologs mouse all