ANKRD27, Official Symbol ANKRD27provided by HGNC Official Full Name ankyrin repeat domain 27provided by HGNC Primary source HGNC:HGNC:25310 See related Ensembl:ENSG00000105186 MIM:618957; AllianceGenome:HGNC:25310 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VARP; PP12899 Summary Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endocytic recycling and negative regulation of SNARE complex assembly. Acts upstream of or within early endosome to late endosome transport. Located in endosome; lysosome; and plasma membrane. Implicated in eosinophilic esophagitis. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 13.4), thyroid (RPKM 8.9) and 25 other tissues See more Orthologs mouse all