PLCZ1, Official Symbol PLCZ1provided by HGNC Official Full Name phospholipase C zeta 1provided by HGNC Primary source HGNC:HGNC:19218 See related Ensembl:ENSG00000139151 MIM:608075; AllianceGenome:HGNC:19218 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPGF17; PLCzeta; NYD-SP27; PLC-zeta-1 Summary The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Restricted expression toward testis (RPKM 5.9) See more Orthologs mouse all