XRCC3, Official Symbol XRCC3provided by HGNC Official Full Name X-ray repair cross complementing 3provided by HGNC Primary source HGNC:HGNC:12830 See related Ensembl:ENSG00000126215 MIM:600675; AllianceGenome:HGNC:12830 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMM6 Summary This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 5.7), skin (RPKM 5.6) and 25 other tissues See more Orthologs mouse all