SPINT2, Official Symbol SPINT2provided by HGNC Official Full Name serine peptidase inhibitor, Kunitz type 2provided by HGNC Primary source HGNC:HGNC:11247 See related Ensembl:ENSG00000167642 MIM:605124; AllianceGenome:HGNC:11247 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PB; Kop; HAI2; DIAR3; HAI-2 Summary This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Broad expression in colon (RPKM 172.2), thyroid (RPKM 135.2) and 22 other tissues See more Orthologs mouse all