DCAF6, Official Symbol DCAF6provided by HGNC Official Full Name DDB1 and CUL4 associated factor 6provided by HGNC Primary source HGNC:HGNC:30002 See related Ensembl:ENSG00000143164 MIM:610494; AllianceGenome:HGNC:30002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik Summary The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017] Expression Broad expression in testis (RPKM 48.7), heart (RPKM 45.3) and 24 other tissues See more Orthologs mouse all