F11R, Official Symbol F11Rprovided by HGNC Official Full Name F11 receptorprovided by HGNC Primary source HGNC:HGNC:14685 See related Ensembl:ENSG00000158769 MIM:605721; AllianceGenome:HGNC:14685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1 Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues See more Orthologs mouse all