STAB1, Official Symbol STAB1provided by HGNC Official Full Name stabilin 1provided by HGNC Primary source HGNC:HGNC:18628 See related Ensembl:ENSG00000010327 MIM:608560; AllianceGenome:HGNC:18628 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEX1; FEEL1; FEEL-1; FELE-1; SCARH2; STAB-1; CLEVER-1 Summary This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 55.7), placenta (RPKM 32.7) and 21 other tissues See more Orthologs mouse all