CLCNKA, Official Symbol CLCNKAprovided by HGNC Official Full Name chloride voltage-gated channel Kaprovided by HGNC Primary source HGNC:HGNC:2026 See related Ensembl:ENSG00000186510 MIM:602024; AllianceGenome:HGNC:2026 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLCK1; ClC-K1; hClC-Ka Summary This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 55.9), salivary gland (RPKM 4.5) and 1 other tissue See more Orthologs all