IRF8, Official Symbol IRF8provided by HGNC Official Full Name interferon regulatory factor 8provided by HGNC Primary source HGNC:HGNC:5358 See related Ensembl:ENSG00000140968 MIM:601565; AllianceGenome:HGNC:5358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP Summary Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 108.4), spleen (RPKM 67.5) and 11 other tissues See more Orthologs mouse all