FAT2, Official Symbol FAT2provided by HGNC Official Full Name FAT atypical cadherin 2provided by HGNC Primary source HGNC:HGNC:3596 See related Ensembl:ENSG00000086570 MIM:604269; AllianceGenome:HGNC:3596 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDHF8; CDHR9; HFAT2; MEGF1; SCA45 Summary This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 15.3), esophagus (RPKM 6.4) and 3 other tissues See more Orthologs mouse all