DOHH, Official Symbol DOHHprovided by HGNC Official Full Name deoxyhypusine hydroxylaseprovided by HGNC Primary source HGNC:HGNC:28662 See related Ensembl:ENSG00000129932 MIM:611262; AllianceGenome:HGNC:28662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLRC1; hDOHH; NEDMVIC Summary This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] Expression Ubiquitous expression in kidney (RPKM 3.6), brain (RPKM 3.1) and 25 other tissues See more Orthologs mouse all