CALR3, Official Symbol CALR3provided by HGNC Official Full Name calreticulin 3provided by HGNC Primary source HGNC:HGNC:20407 See related Ensembl:ENSG00000269058 MIM:611414; AllianceGenome:HGNC:20407 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRT2; CT93; CMH19 Summary The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011] Expression Restricted expression toward testis (RPKM 33.9) See more Orthologs mouse all