UNC93B1, Official Symbol UNC93B1provided by HGNC Official Full Name unc-93 homolog B1, TLR signaling regulatorprovided by HGNC Primary source HGNC:HGNC:13481 See related Ensembl:ENSG00000110057 MIM:608204; AllianceGenome:HGNC:13481 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IIAE1; UNC93; UNC93B; Unc-93B1 Summary This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014] Expression Broad expression in spleen (RPKM 27.3), lung (RPKM 14.0) and 24 other tissues See more Orthologs mouse all