SLC6A2, Official Symbol SLC6A2provided by HGNC Official Full Name solute carrier family 6 member 2provided by HGNC Primary source HGNC:HGNC:11048 See related Ensembl:ENSG00000103546 MIM:163970; AllianceGenome:HGNC:11048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NET; NAT1; NET1; SLC6A5 Summary This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] Annotation information Note: NET is an alias on both SLC6A2 (Gene ID: 6530, "norepinephrine transporter") and ELK3 (Gene ID: 2004). [01 Jun 2018] Expression Biased expression in adrenal (RPKM 4.7), placenta (RPKM 2.3) and 3 other tissues See more Orthologs mouse all