CAMK2B, Official Symbol CAMK2Bprovided by HGNC Official Full Name calcium/calmodulin dependent protein kinase II betaprovided by HGNC Primary source HGNC:HGNC:1461 See related Ensembl:ENSG00000058404 MIM:607707; AllianceGenome:HGNC:1461 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta Summary The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues See more Orthologs mouse all