IRS1, Official Symbol IRS1provided by HGNC Official Full Name insulin receptor substrate 1provided by HGNC Primary source HGNC:HGNC:6125 See related Ensembl:ENSG00000169047 MIM:147545; AllianceGenome:HGNC:6125 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HIRS-1 Summary This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] Expression Broad expression in thyroid (RPKM 15.0), endometrium (RPKM 12.3) and 22 other tissues See more Orthologs mouse all