SCD5, Official Symbol SCD5provided by HGNC Official Full Name stearoyl-CoA desaturase 5provided by HGNC Primary source HGNC:HGNC:21088 See related Ensembl:ENSG00000145284 MIM:608370; AllianceGenome:HGNC:21088 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCD2; SCD4; ACOD4; FADS4; HSCD5; DFNA79 Summary Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008] Expression Biased expression in brain (RPKM 129.6), adrenal (RPKM 62.7) and 5 other tissues See more Orthologs mouse all