PDIA6, Official Symbol PDIA6provided by HGNC Official Full Name protein disulfide isomerase family A member 6provided by HGNC Primary source HGNC:HGNC:30168 See related Ensembl:ENSG00000143870 MIM:611099; AllianceGenome:HGNC:30168 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P5; ERP5; TXNDC7 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in thyroid (RPKM 159.7), placenta (RPKM 70.6) and 25 other tissues See more Orthologs mouse all