SIM2, Official Symbol SIM2provided by HGNC Official Full Name SIM bHLH transcription factor 2provided by HGNC Primary source HGNC:HGNC:10883 See related Ensembl:ENSG00000159263 MIM:600892; AllianceGenome:HGNC:10883 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIM; bHLHe15; HMC13F06; HMC29C01 Summary This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Biased expression in kidney (RPKM 5.4), esophagus (RPKM 4.7) and 4 other tissues See more Orthologs mouse all