SLC5A5, Official Symbol SLC5A5provided by HGNC Official Full Name solute carrier family 5 member 5provided by HGNC Primary source HGNC:HGNC:11040 See related Ensembl:ENSG00000105641 MIM:601843; AllianceGenome:HGNC:11040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIS; TDH1 Summary This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009] Expression Biased expression in stomach (RPKM 21.5), salivary gland (RPKM 11.5) and 1 other tissue See more Orthologs mouse all