IL21, Official Symbol IL21provided by HGNC Official Full Name interleukin 21provided by HGNC Primary source HGNC:HGNC:6005 See related Ensembl:ENSG00000138684 MIM:605384; AllianceGenome:HGNC:6005 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Za11; IL-21; CVID11 Summary This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in lymph node (RPKM 3.2), testis (RPKM 0.8) and 2 other tissues See more Orthologs mouse all