NFE2L2, Official Symbol NFE2L2provided by HGNC Official Full Name NFE2 like bZIP transcription factor 2provided by HGNC Primary source HGNC:HGNC:7782 See related Ensembl:ENSG00000116044 MIM:600492; AllianceGenome:HGNC:7782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRF2; HEBP1; Nrf-2; IMDDHH Summary This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in esophagus (RPKM 93.8), thyroid (RPKM 52.1) and 24 other tissues See more Orthologs mouse all