CRB3, Official Symbol CRB3provided by HGNC Official Full Name crumbs cell polarity complex component 3provided by HGNC Primary source HGNC:HGNC:20237 See related Ensembl:ENSG00000130545 MIM:609737; AllianceGenome:HGNC:20237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Expression Broad expression in colon (RPKM 9.7), duodenum (RPKM 9.6) and 16 other tissues See more Orthologs mouse all