KCNN1, Official Symbol KCNN1provided by HGNC Official Full Name potassium calcium-activated channel subfamily N member 1provided by HGNC Primary source HGNC:HGNC:6290 See related Ensembl:ENSG00000105642 MIM:602982; AllianceGenome:HGNC:6290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK1; hSK1; SKCA1; KCa2.1 Summary Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 5.8), testis (RPKM 0.7) and 1 other tissue See more Orthologs mouse all