HLA-DOA, Official Symbol HLA-DOAprovided by HGNC Official Full Name major histocompatibility complex, class II, DO alphaprovided by HGNC Primary source HGNC:HGNC:4936 See related Ensembl:ENSG00000204252 MIM:142930; AllianceGenome:HGNC:4936 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLADZ; HLA-DNA; HLA-DZA Summary HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 26.6), spleen (RPKM 26.2) and 20 other tissues See more Orthologs mouse all