GUF1, Official Symbol GUF1provided by HGNC Official Full Name GTP binding elongation factor GUF1provided by HGNC Primary source HGNC:HGNC:25799 See related Ensembl:ENSG00000151806 MIM:617064; AllianceGenome:HGNC:25799 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EF4; EF-4; DEE40; EIEE40 Summary This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 5.7), testis (RPKM 4.4) and 25 other tissues See more Orthologs mouse all