WRAP53, Official Symbol WRAP53provided by HGNC Official Full Name WD repeat containing antisense to TP53provided by HGNC Primary source HGNC:HGNC:25522 See related Ensembl:ENSG00000141499 MIM:612661; AllianceGenome:HGNC:25522 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKCB3; TCAB1; WDR79 Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues See more Orthologs mouse all