OLIG2, Official Symbol OLIG2provided by HGNC Official Full Name oligodendrocyte transcription factor 2provided by HGNC Primary source HGNC:HGNC:9398 See related Ensembl:ENSG00000205927 MIM:606386; AllianceGenome:HGNC:9398 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19 Summary This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] Expression Restricted expression toward brain (RPKM 29.0) See more Orthologs mouse all