SREBF2, Official Symbol SREBF2provided by HGNC Official Full Name sterol regulatory element binding transcription factor 2provided by HGNC Primary source HGNC:HGNC:11290 See related Ensembl:ENSG00000198911 MIM:600481; AllianceGenome:HGNC:11290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SREBP2; bHLHd2; SREBP-2 Summary This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in brain (RPKM 36.5), esophagus (RPKM 27.8) and 25 other tissues See more Orthologs mouse all