AFF3, Official Symbol AFF3provided by HGNC Official Full Name ALF transcription elongation factor 3provided by HGNC Primary source HGNC:HGNC:6473 See related Ensembl:ENSG00000144218 MIM:601464; AllianceGenome:HGNC:6473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KINS; LAF4; MLLT2-like Summary This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 4.8), lymph node (RPKM 3.7) and 23 other tissues See more Orthologs mouse all