GUCY1A2, Official Symbol GUCY1A2provided by HGNC Official Full Name guanylate cyclase 1 soluble subunit alpha 2provided by HGNC Primary source HGNC:HGNC:4684 See related Ensembl:ENSG00000152402 MIM:601244; AllianceGenome:HGNC:4684 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GC-SA2; GUC1A2 Summary Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in endometrium (RPKM 8.8), placenta (RPKM 7.4) and 15 other tissues See more Orthologs mouse all