GIPR, Official Symbol GIPRprovided by HGNC Official Full Name gastric inhibitory polypeptide receptorprovided by HGNC Primary source HGNC:HGNC:4271 See related Ensembl:ENSG00000010310 MIM:137241; AllianceGenome:HGNC:4271 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGQTL2 Summary This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] Expression Broad expression in stomach (RPKM 5.3), fat (RPKM 1.5) and 16 other tissues See more Orthologs mouse all