AP3B2, Official Symbol AP3B2provided by HGNC Official Full Name adaptor related protein complex 3 subunit beta 2provided by HGNC Primary source HGNC:HGNC:567 See related Ensembl:ENSG00000103723 MIM:602166; AllianceGenome:HGNC:567 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE48; NAPTB; EIEE48 Summary Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017] Expression Biased expression in brain (RPKM 16.0), testis (RPKM 3.0) and 1 other tissue See more Orthologs mouse all