ATP4B, Official Symbol ATP4Bprovided by HGNC Official Full Name ATPase H+/K+ transporting subunit betaprovided by HGNC Primary source HGNC:HGNC:820 See related Ensembl:ENSG00000186009 MIM:137217; AllianceGenome:HGNC:820 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATP6B Summary The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008] Expression Restricted expression toward stomach (RPKM 286.6) See more Orthologs mouse all