CDC42EP5, Official Symbol CDC42EP5provided by HGNC Official Full Name CDC42 effector protein 5provided by HGNC Primary source HGNC:HGNC:17408 See related Ensembl:ENSG00000167617 MIM:609171; AllianceGenome:HGNC:17408 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEP5; Borg3 Summary Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013] Expression Biased expression in colon (RPKM 54.5), prostate (RPKM 21.2) and 11 other tissues See more Orthologs mouse all