EPHA3, Official Symbol EPHA3provided by HGNC Official Full Name EPH receptor A3provided by HGNC Primary source HGNC:HGNC:3387 See related Ensembl:ENSG00000044524 MIM:179611; AllianceGenome:HGNC:3387 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EK4; ETK; HEK; ETK1; HEK4; TYRO4 Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 12.7), gall bladder (RPKM 11.9) and 18 other tissues See more Orthologs mouse all