TBX21, Official Symbol TBX21provided by HGNC Official Full Name T-box transcription factor 21provided by HGNC Primary source HGNC:HGNC:11599 See related Ensembl:ENSG00000073861 MIM:604895; AllianceGenome:HGNC:11599 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TBET; IMD88; T-PET; T-bet; TBLYM Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 4.5), bone marrow (RPKM 4.1) and 12 other tissues See more Orthologs mouse all