SRD5A2, Official Symbol SRD5A2provided by HGNC Official Full Name steroid 5 alpha-reductase 2provided by HGNC Primary source HGNC:HGNC:11285 See related Ensembl:ENSG00000277893 MIM:607306; AllianceGenome:HGNC:11285 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 13.3), prostate (RPKM 8.5) and 2 other tissues See more Orthologs mouse all