PRSS21, Official Symbol PRSS21provided by HGNC Official Full Name serine protease 21provided by HGNC Primary source HGNC:HGNC:9485 See related Ensembl:ENSG00000007038 MIM:608159; AllianceGenome:HGNC:9485 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESP1; ESP-1; TEST1; TESTISIN Summary This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Biased expression in testis (RPKM 26.0), bone marrow (RPKM 4.4) and 4 other tissues See more Orthologs all