ENPP1, Official Symbol ENPP1provided by HGNC Official Full Name ectonucleotide pyrophosphatase/phosphodiesterase 1provided by HGNC Primary source HGNC:HGNC:3356 See related Ensembl:ENSG00000197594 MIM:173335; AllianceGenome:HGNC:3356 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1 Summary This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 22.6), thyroid (RPKM 14.0) and 13 other tissues See more Orthologs mouse all