GFI1B, Official Symbol GFI1Bprovided by HGNC Official Full Name growth factor independent 1B transcriptional repressorprovided by HGNC Primary source HGNC:HGNC:4238 See related Ensembl:ENSG00000165702 MIM:604383; AllianceGenome:HGNC:4238 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDPLT17; ZNF163B Summary This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] Expression Biased expression in bone marrow (RPKM 8.3) and testis (RPKM 0.5) See more Orthologs mouse all