TASP1, Official Symbol TASP1provided by HGNC Official Full Name taspase 1provided by HGNC Primary source HGNC:HGNC:15859 See related Ensembl:ENSG00000089123 MIM:608270; AllianceGenome:HGNC:15859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SULEHS; C20orf13; dJ585I14.2 Summary This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 2.9), testis (RPKM 2.2) and 25 other tissues See more Orthologs mouse all