ASCL2, Official Symbol ASCL2provided by HGNC Official Full Name achaete-scute family bHLH transcription factor 2provided by HGNC Primary source HGNC:HGNC:739 See related Ensembl:ENSG00000183734 MIM:601886; AllianceGenome:HGNC:739 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASH2; HASH2; MASH2; bHLHa45 Summary This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 4.3), placenta (RPKM 2.5) and 14 other tissues See more Orthologs mouse all