ARHGEF15, Official Symbol ARHGEF15provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 15provided by HGNC Primary source HGNC:HGNC:15590 See related Ensembl:ENSG00000198844 MIM:608504; AllianceGenome:HGNC:15590 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E5; ARGEF15; Ephexin5; Vsm-RhoGEF Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010] Expression Broad expression in fat (RPKM 15.9), lung (RPKM 13.8) and 19 other tissues See more Orthologs mouse all