MAP3K12, Official Symbol MAP3K12provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 12provided by HGNC Primary source HGNC:HGNC:6851 See related Ensembl:ENSG00000139625 MIM:600447; AllianceGenome:HGNC:6851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DLK; MUK; ZPK; ZPKP1; MEKK12; HP09298 Summary This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] Expression Ubiquitous expression in urinary bladder (RPKM 14.0), brain (RPKM 12.1) and 25 other tissues See more Orthologs mouse all