TNFRSF9, Official Symbol TNFRSF9provided by HGNC Official Full Name TNF receptor superfamily member 9provided by HGNC Primary source HGNC:HGNC:11924 See related Ensembl:ENSG00000049249 MIM:602250; AllianceGenome:HGNC:11924 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILA; 4-1BB; CD137; CDw137; IMD109 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 2.6), appendix (RPKM 1.1) and 6 other tissues See more Orthologs mouse all