RHBDF2, Official Symbol RHBDF2provided by HGNC Official Full Name rhomboid 5 homolog 2provided by HGNC Primary source HGNC:HGNC:20788 See related Ensembl:ENSG00000129667 MIM:614404; AllianceGenome:HGNC:20788 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOC; TOCG; RHBDL5; RHBDL6; iRhom2 Summary Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 8.7), appendix (RPKM 7.3) and 25 other tissues See more Orthologs mouse all