PCNT, Official Symbol PCNTprovided by HGNC Official Full Name pericentrinprovided by HGNC Primary source HGNC:HGNC:16068 See related Ensembl:ENSG00000160299 MIM:605925; AllianceGenome:HGNC:16068 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KEN; PCN; MOPD2; PCNT2; PCNTB; PCTN2; SCKL4 Summary The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Broad expression in testis (RPKM 8.6), bone marrow (RPKM 5.3) and 24 other tissues See more Orthologs mouse all