MAP3K1, Official Symbol MAP3K1provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 1provided by HGNC Primary source HGNC:HGNC:6848 See related Ensembl:ENSG00000095015 MIM:600982; AllianceGenome:HGNC:6848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1 Summary The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in spleen (RPKM 8.6), skin (RPKM 8.4) and 25 other tissues See more Orthologs mouse all