ARAP2, Official Symbol ARAP2provided by HGNC Official Full Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2provided by HGNC Primary source HGNC:HGNC:16924 See related Ensembl:ENSG00000047365 MIM:606645; AllianceGenome:HGNC:16924 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARX; CENTD1 Summary The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008] Expression Broad expression in thyroid (RPKM 5.9), brain (RPKM 5.8) and 22 other tissues See more Orthologs mouse all