NPY1R, Official Symbol NPY1Rprovided by HGNC Official Full Name neuropeptide Y receptor Y1provided by HGNC Primary source HGNC:HGNC:7956 See related Ensembl:ENSG00000164128 MIM:162641; AllianceGenome:HGNC:7956 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPYR; NPY1-R Summary This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013] Expression Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more Orthologs mouse all