TIGAR, Official Symbol TIGARprovided by HGNC Official Full Name TP53 induced glycolysis regulatory phosphataseprovided by HGNC Primary source HGNC:HGNC:1185 See related Ensembl:ENSG00000078237 MIM:610775; AllianceGenome:HGNC:1185 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FR2BP; C12orf5 Summary This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in urinary bladder (RPKM 2.3), colon (RPKM 2.2) and 24 other tissues See more Orthologs mouse all