BMP3, Official Symbol BMP3provided by HGNC Official Full Name bone morphogenetic protein 3provided by HGNC Primary source HGNC:HGNC:1070 See related Ensembl:ENSG00000152785 MIM:112263; AllianceGenome:HGNC:1070 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMP-3A Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016] Expression Biased expression in urinary bladder (RPKM 12.1), colon (RPKM 5.2) and 5 other tissues See more Orthologs mouse all