ADGRL1, Official Symbol ADGRL1provided by HGNC Official Full Name adhesion G protein-coupled receptor L1provided by HGNC Primary source HGNC:HGNC:20973 See related Ensembl:ENSG00000072071 MIM:616416; AllianceGenome:HGNC:20973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL1; LEC2; CIRL1; LPHN1; DEDBANP Summary This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] Expression Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues See more Orthologs mouse all