BUB1B, Official Symbol BUB1Bprovided by HGNC Official Full Name BUB1 mitotic checkpoint serine/threonine kinase Bprovided by HGNC Primary source HGNC:HGNC:1149 See related Ensembl:ENSG00000156970 MIM:602860; AllianceGenome:HGNC:1149 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MVA1; SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta Summary This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 16.5), bone marrow (RPKM 7.5) and 12 other tissues See more Orthologs mouse all