OGFR, Official Symbol OGFRprovided by HGNC Official Full Name opioid growth factor receptorprovided by HGNC Primary source HGNC:HGNC:15768 See related Ensembl:ENSG00000060491 MIM:606459; AllianceGenome:HGNC:15768 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 22.4), lung (RPKM 12.6) and 25 other tissues See more Orthologs mouse all