DHCR24, Official Symbol DHCR24provided by HGNC Official Full Name 24-dehydrocholesterol reductaseprovided by HGNC Primary source HGNC:HGNC:2859 See related Ensembl:ENSG00000116133 MIM:606418; AllianceGenome:HGNC:2859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCE; SELADIN1; Nbla03646; seladin-1 Summary This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 515.3), liver (RPKM 200.4) and 12 other tissues See more Orthologs mouse all