CNTNAP1, Official Symbol CNTNAP1provided by HGNC Official Full Name contactin associated protein 1provided by HGNC Primary source HGNC:HGNC:8011 See related Ensembl:ENSG00000108797 MIM:602346; AllianceGenome:HGNC:8011 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHN3; P190; CASPR; NRXN4; CNTNAP Summary The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009] Expression Broad expression in brain (RPKM 18.9), endometrium (RPKM 5.5) and 17 other tissues See more Orthologs mouse all