GAPDHS, Official Symbol GAPDHSprovided by HGNC Official Full Name glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by HGNC Primary source HGNC:HGNC:24864 See related Ensembl:ENSG00000105679 MIM:609169; AllianceGenome:HGNC:24864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278 Summary This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9) See more Orthologs mouse all