PLA2G12B, Official Symbol PLA2G12Bprovided by HGNC Official Full Name phospholipase A2 group XIIBprovided by HGNC Primary source HGNC:HGNC:18555 See related Ensembl:ENSG00000138308 MIM:611653; AllianceGenome:HGNC:18555 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GXIIB; FKSG71; PLA2G13; GXIIIsPLA2; sPLA2-GXIIB Summary The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in liver (RPKM 15.3), small intestine (RPKM 14.6) and 5 other tissues See more Orthologs mouse all