TLN1, Official Symbol TLN1provided by HGNC Official Full Name talin 1provided by HGNC Primary source HGNC:HGNC:11845 See related Ensembl:ENSG00000137076 MIM:186745; AllianceGenome:HGNC:11845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLN; ILWEQ; talin-1 Summary This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009] Expression Ubiquitous expression in fat (RPKM 74.7), spleen (RPKM 60.6) and 25 other tissues See more Orthologs mouse all