DEDD2, Official Symbol DEDD2provided by HGNC Official Full Name death effector domain containing 2provided by HGNC Primary source HGNC:HGNC:24450 See related Ensembl:ENSG00000160570 MIM:617078; AllianceGenome:HGNC:24450 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLAME3; FLAME-3 Summary This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in bone marrow (RPKM 24.8), spleen (RPKM 9.9) and 25 other tissues See more Orthologs mouse all