CIDEA, Official Symbol CIDEAprovided by HGNC Official Full Name cell death inducing DFFA like effector aprovided by HGNC Primary source HGNC:HGNC:1976 See related Ensembl:ENSG00000176194 MIM:604440; AllianceGenome:HGNC:1976 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIDE-A Summary This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010] Expression Restricted expression toward fat (RPKM 78.2) See more Orthologs mouse all