HCRT, Official Symbol HCRTprovided by HGNC Official Full Name hypocretin neuropeptide precursorprovided by HGNC Primary source HGNC:HGNC:4847 See related Ensembl:ENSG00000161610 MIM:602358; AllianceGenome:HGNC:4847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX; PPOX; NRCLP1 Summary This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all