FOLR1, Official Symbol FOLR1provided by HGNC Official Full Name folate receptor alphaprovided by HGNC Primary source HGNC:HGNC:3791 See related Ensembl:ENSG00000110195 MIM:136430; AllianceGenome:HGNC:3791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP; FOLR; NCFTD; FRalpha Summary The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] Expression Biased expression in lung (RPKM 83.5), kidney (RPKM 59.8) and 4 other tissues See more Orthologs mouse all