UBR7, Official Symbol UBR7provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 7provided by HGNC Primary source HGNC:HGNC:20344 See related Ensembl:ENSG00000012963 MIM:613816; AllianceGenome:HGNC:20344 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LICAS; C14orf130 Summary This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in brain (RPKM 15.7), testis (RPKM 15.4) and 25 other tissues See more Orthologs mouse all