YAP1, Official Symbol YAP1provided by HGNC Official Full Name Yes1 associated transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:16262 See related Ensembl:ENSG00000137693 MIM:606608; AllianceGenome:HGNC:16262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YAP; YKI; COB1; YAP2; YAP-1; YAP65 Summary This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in thyroid (RPKM 45.0), endometrium (RPKM 38.7) and 23 other tissues See more Orthologs mouse all