FGF2, Official Symbol FGF2provided by HGNC Official Full Name fibroblast growth factor 2provided by HGNC Primary source HGNC:HGNC:3676 See related Ensembl:ENSG00000138685 MIM:134920; AllianceGenome:HGNC:3676 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BFGF; FGFB; FGF-2; HBGF-2 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 17.2), endometrium (RPKM 8.8) and 21 other tissues See more Orthologs mouse all