IRAK3, Official Symbol IRAK3provided by HGNC Official Full Name interleukin 1 receptor associated kinase 3provided by HGNC Primary source HGNC:HGNC:17020 See related Ensembl:ENSG00000090376 MIM:604459; AllianceGenome:HGNC:17020 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASRT5; IRAKM Summary This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Broad expression in bone marrow (RPKM 10.8), spleen (RPKM 8.1) and 21 other tissues See more Orthologs mouse all