SI, Official Symbol SIprovided by HGNC Official Full Name sucrase-isomaltaseprovided by HGNC Primary source HGNC:HGNC:10856 See related Ensembl:ENSG00000090402 MIM:609845; AllianceGenome:HGNC:10856 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010] Expression Biased expression in duodenum (RPKM 299.9), small intestine (RPKM 254.2) and 1 other tissue See more Orthologs mouse all