GEMIN4, Official Symbol GEMIN4provided by HGNC Official Full Name gem nuclear organelle associated protein 4provided by HGNC Primary source HGNC:HGNC:15717 See related Ensembl:ENSG00000179409 MIM:606969; AllianceGenome:HGNC:15717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p97; HC56; HCAP1; HHRF-1; NEDMCR Summary The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 20.3), skin (RPKM 9.4) and 23 other tissues See more Orthologs mouse all