PLB1, Official Symbol PLB1provided by HGNC Official Full Name phospholipase B1provided by HGNC Primary source HGNC:HGNC:30041 See related Ensembl:ENSG00000163803 MIM:610179; AllianceGenome:HGNC:30041 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLB; PLB/LIP Summary This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016] Expression Biased expression in small intestine (RPKM 8.9), bone marrow (RPKM 1.8) and 8 other tissues See more Orthologs mouse all