ERLIN1, Official Symbol ERLIN1provided by HGNC Official Full Name ER lipid raft associated 1provided by HGNC Primary source HGNC:HGNC:16947 See related Ensembl:ENSG00000107566 MIM:611604; AllianceGenome:HGNC:16947 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69 Summary The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in bone marrow (RPKM 24.9), liver (RPKM 24.8) and 25 other tissues See more Orthologs mouse all