ATG10, Official Symbol ATG10provided by HGNC Official Full Name autophagy related 10provided by HGNC Primary source HGNC:HGNC:20315 See related Ensembl:ENSG00000152348 MIM:610800; AllianceGenome:HGNC:20315 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APG10; APG10L; pp12616 Summary Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 1.1), thyroid (RPKM 0.8) and 25 other tissues See more Orthologs mouse all