ARAP3, Official Symbol ARAP3provided by HGNC Official Full Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by HGNC Primary source HGNC:HGNC:24097 See related Ensembl:ENSG00000120318 MIM:606647; AllianceGenome:HGNC:24097 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRAG1; CENTD3 Summary This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015] Expression Broad expression in lung (RPKM 9.2), fat (RPKM 7.9) and 24 other tissues See more Orthologs mouse all