TUB, Official Symbol TUBprovided by HGNC Official Full Name TUB bipartite transcription factorprovided by HGNC Primary source HGNC:HGNC:12406 See related Ensembl:ENSG00000166402 MIM:601197; AllianceGenome:HGNC:12406 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as rd5; RDOB Summary This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 18.8), endometrium (RPKM 10.0) and 21 other tissues See more Orthologs mouse all