CHRNB4, Official Symbol CHRNB4provided by HGNC Official Full Name cholinergic receptor nicotinic beta 4 subunitprovided by HGNC Primary source HGNC:HGNC:1964 See related Ensembl:ENSG00000117971 MIM:118509; AllianceGenome:HGNC:1964 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017] Expression Biased expression in testis (RPKM 1.1), adrenal (RPKM 0.6) and 7 other tissues See more Orthologs mouse all