C1orf56, Official Symbol C1orf56provided by HGNC Official Full Name chromosome 1 open reading frame 56provided by HGNC Primary source HGNC:HGNC:26045 See related Ensembl:ENSG00000143443 AllianceGenome:HGNC:26045 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MENT Summary This gene is a proto-oncogene whose promoter is methylated by DNA methyltransferase 3B (DNMT3B), which represses the proto-oncogene. However, a catalytically inactive isoform of DNMT3B is overexpressed in lymphomas, leading to hypomethylation of the proto-oncogene's promoter and derepression of the proto-oncogene. [provided by RefSeq, Sep 2016] Expression Broad expression in testis (RPKM 26.8), spleen (RPKM 8.3) and 24 other tissues See more Orthologs mouse all