LARS1, Official Symbol LARS1provided by HGNC Official Full Name leucyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:6512 See related Ensembl:ENSG00000133706 MIM:151350; AllianceGenome:HGNC:6512 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRS; LARS; LEUS; LFIS; ILFS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl Summary This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in thyroid (RPKM 24.0), brain (RPKM 19.6) and 25 other tissues See more Orthologs mouse all