FOXN1, Official Symbol FOXN1provided by HGNC Official Full Name forkhead box N1provided by HGNC Primary source HGNC:HGNC:12765 See related Ensembl:ENSG00000109101 MIM:600838; AllianceGenome:HGNC:12765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WHN; RONU; TLIND; FKHL20; TIDAND Summary Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 9.7) and esophagus (RPKM 2.5) See more Orthologs mouse all