AFG3L2, Official Symbol AFG3L2provided by HGNC Official Full Name AFG3 like matrix AAA peptidase subunit 2provided by HGNC Primary source HGNC:HGNC:315 See related Ensembl:ENSG00000141385 MIM:604581; AllianceGenome:HGNC:315 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPA12; SCA28; SPAX5 Summary This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 38.9), heart (RPKM 35.3) and 25 other tissues See more Orthologs mouse all