TMPO, Official Symbol TMPOprovided by HGNC Official Full Name thymopoietinprovided by HGNC Primary source HGNC:HGNC:11875 See related Ensembl:ENSG00000120802 MIM:188380; AllianceGenome:HGNC:11875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP; LAP2; CMD1T; LEMD4; PRO0868 Summary Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019] Expression Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues See more Orthologs mouse all