TMC8, Official Symbol TMC8provided by HGNC Official Full Name transmembrane channel like 8provided by HGNC Primary source HGNC:HGNC:20474 See related Ensembl:ENSG00000167895 MIM:605829; AllianceGenome:HGNC:20474 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EV2; EVER2; EVIN2 Summary Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 30.6), spleen (RPKM 30.0) and 9 other tissues See more Orthologs mouse all