DOK5, Official Symbol DOK5provided by HGNC Official Full Name docking protein 5provided by HGNC Primary source HGNC:HGNC:16173 See related Ensembl:ENSG00000101134 MIM:608334; AllianceGenome:HGNC:16173 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRS6; IRS-6; C20orf180 Summary The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Biased expression in brain (RPKM 5.9), heart (RPKM 5.0) and 12 other tissues See more Orthologs mouse all