NTRK1, Official Symbol NTRK1provided by HGNC Official Full Name neurotrophic receptor tyrosine kinase 1provided by HGNC Primary source HGNC:HGNC:8031 See related Ensembl:ENSG00000198400 MIM:191315; AllianceGenome:HGNC:8031 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA Summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 3.7), testis (RPKM 1.0) and 10 other tissues See more Orthologs mouse all