CMA1, Official Symbol CMA1provided by HGNC Official Full Name chymase 1provided by HGNC Primary source HGNC:HGNC:2097 See related Ensembl:ENSG00000092009 MIM:118938; AllianceGenome:HGNC:2097 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYH; MCT1; chymase Summary This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015] Expression Biased expression in colon (RPKM 6.3), esophagus (RPKM 4.1) and 11 other tissues See more Orthologs mouse all