BMP7, Official Symbol BMP7provided by HGNC Official Full Name bone morphogenetic protein 7provided by HGNC Primary source HGNC:HGNC:1074 See related Ensembl:ENSG00000101144 MIM:112267; AllianceGenome:HGNC:1074 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OP-1 Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016] Expression Biased expression in thyroid (RPKM 30.0), placenta (RPKM 15.8) and 9 other tissues See more Orthologs mouse all