DHH, Official Symbol DHHprovided by HGNC Official Full Name desert hedgehog signaling moleculeprovided by HGNC Primary source HGNC:HGNC:2865 See related Ensembl:ENSG00000139549 MIM:605423; AllianceGenome:HGNC:2865 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDMN; GDXYM; HHG-3; SRXY7 Summary This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010] Expression Biased expression in testis (RPKM 5.9) and appendix (RPKM 0.3) See more Orthologs mouse all