NDUFS4, Official Symbol NDUFS4provided by HGNC Official Full Name NADH:ubiquinone oxidoreductase subunit S4provided by HGNC Primary source HGNC:HGNC:7711 See related Ensembl:ENSG00000164258 MIM:602694; AllianceGenome:HGNC:7711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AQDQ; CI-18; MC1DN1; CI-AQDQ; CI-18 kDa Summary This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in heart (RPKM 25.7), fat (RPKM 23.7) and 25 other tissues See more Orthologs mouse all