COBL, Official Symbol COBLprovided by HGNC Official Full Name cordon-bleu WH2 repeat proteinprovided by HGNC Primary source HGNC:HGNC:22199 See related Ensembl:ENSG00000106078 MIM:610317; AllianceGenome:HGNC:22199 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016] Expression Broad expression in brain (RPKM 13.9), heart (RPKM 7.3) and 18 other tissues See more Orthologs mouse all