TIE1, Official Symbol TIE1provided by HGNC Official Full Name tyrosine kinase with immunoglobulin like and EGF like domains 1provided by HGNC Primary source HGNC:HGNC:11809 See related Ensembl:ENSG00000066056 MIM:600222; AllianceGenome:HGNC:11809 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIE; JTK14; LMPHM11 Summary This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Expression Broad expression in placenta (RPKM 23.3), fat (RPKM 19.2) and 21 other tissues See more Orthologs mouse all