PRAME, Official Symbol PRAMEprovided by HGNC Official Full Name PRAME nuclear receptor transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:9336 See related Ensembl:ENSG00000185686 MIM:606021; AllianceGenome:HGNC:9336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAPE; OIP4; CT130; OIP-4 Summary This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Restricted expression toward testis (RPKM 47.0) See more Orthologs all