HCST, Official Symbol HCSTprovided by HGNC Official Full Name hematopoietic cell signal transducerprovided by HGNC Primary source HGNC:HGNC:16977 See related Ensembl:ENSG00000126264 MIM:604089; AllianceGenome:HGNC:16977 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAP10; KAP10; PIK3AP Summary This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 39.5), spleen (RPKM 20.3) and 12 other tissues See more Orthologs mouse all