BDKRB1, Official Symbol BDKRB1provided by HGNC Official Full Name bradykinin receptor B1provided by HGNC Primary source HGNC:HGNC:1029 See related Ensembl:ENSG00000100739 MIM:600337; AllianceGenome:HGNC:1029 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B1R; BKR1; B1BKR; BKB1R; BRADYB1 Summary Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues See more Orthologs mouse all