PROK1, Official Symbol PROK1provided by HGNC Official Full Name prokineticin 1provided by HGNC Primary source HGNC:HGNC:18454 See related Ensembl:ENSG00000143125 MIM:606233; AllianceGenome:HGNC:18454 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PK1; PRK1; EGVEGF Summary The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011] Expression Biased expression in ovary (RPKM 72.8), testis (RPKM 51.2) and 2 other tissues See more Orthologs mouse all