CLCN4, Official Symbol CLCN4provided by HGNC Official Full Name chloride voltage-gated channel 4provided by HGNC Primary source HGNC:HGNC:2022 See related Ensembl:ENSG00000073464 MIM:302910; AllianceGenome:HGNC:2022 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLC4; ClC-4; MRX15; MRX49; ClC-4A; MRXSRC Summary The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012] Expression Biased expression in brain (RPKM 20.8), heart (RPKM 5.1) and 10 other tissues See more Orthologs mouse all