SIGIRR, Official Symbol SIGIRRprovided by HGNC Official Full Name single Ig and TIR domain containingprovided by HGNC Primary source HGNC:HGNC:30575 See related Ensembl:ENSG00000185187 MIM:605478; AllianceGenome:HGNC:30575 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIR8; IL-1R8 Summary Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues See more Orthologs mouse all