MYOZ2, Official Symbol MYOZ2provided by HGNC Official Full Name myozenin 2provided by HGNC Primary source HGNC:HGNC:1330 See related Ensembl:ENSG00000172399 MIM:605602; AllianceGenome:HGNC:1330 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CS-1; CMH16; C4orf5; FATZ-2 Summary The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011] Expression Restricted expression toward heart (RPKM 236.3) See more Orthologs mouse all