CKAP2L, Official Symbol CKAP2Lprovided by HGNC Official Full Name cytoskeleton associated protein 2 likeprovided by HGNC Primary source HGNC:HGNC:26877 See related Ensembl:ENSG00000169607 MIM:616174; AllianceGenome:HGNC:26877 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Biased expression in bone marrow (RPKM 6.1), testis (RPKM 4.2) and 12 other tissues See more Orthologs mouse all