TIMP2, Official Symbol TIMP2provided by HGNC Official Full Name TIMP metallopeptidase inhibitor 2provided by HGNC Primary source HGNC:HGNC:11821 See related Ensembl:ENSG00000035862 MIM:188825; AllianceGenome:HGNC:11821 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDC8; CSC-21K Summary This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 542.4), endometrium (RPKM 302.2) and 21 other tissues See more Orthologs mouse all