IL11, Official Symbol IL11provided by HGNC Official Full Name interleukin 11provided by HGNC Primary source HGNC:HGNC:5966 See related Ensembl:ENSG00000095752 MIM:147681; AllianceGenome:HGNC:5966 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGIF; IL-11 Summary The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] Expression Biased expression in endometrium (RPKM 2.0), appendix (RPKM 1.5) and 8 other tissues See more Orthologs mouse all