ATG4D, Official Symbol ATG4Dprovided by HGNC Official Full Name autophagy related 4D cysteine peptidaseprovided by HGNC Primary source HGNC:HGNC:20789 See related Ensembl:ENSG00000130734 MIM:611340; AllianceGenome:HGNC:20789 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APG4D; AUTL4; APG4-D; HsAPG4D Summary Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Broad expression in testis (RPKM 21.1), duodenum (RPKM 13.4) and 25 other tissues See more Orthologs mouse all