GTF2A1L, Official Symbol GTF2A1Lprovided by HGNC Official Full Name general transcription factor IIA subunit 1 likeprovided by HGNC Primary source HGNC:HGNC:30727 See related Ensembl:ENSG00000242441 MIM:605358; AllianceGenome:HGNC:30727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALF Summary The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014] Expression Biased expression in testis (RPKM 30.5), endometrium (RPKM 1.9) and 1 other tissue See more Orthologs mouse all