EXOSC1, Official Symbol EXOSC1provided by HGNC Official Full Name exosome component 1provided by HGNC Primary source HGNC:HGNC:17286 See related Ensembl:ENSG00000171311 MIM:606493; AllianceGenome:HGNC:17286 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p13; CSL4; SKI4; Csl4p; PCH1F; Ski4p; CGI-108 Summary This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in lymph node (RPKM 9.3), urinary bladder (RPKM 7.6) and 25 other tissues See more Orthologs mouse all