STK3, Official Symbol STK3provided by HGNC Official Full Name serine/threonine kinase 3provided by HGNC Primary source HGNC:HGNC:11406 See related Ensembl:ENSG00000104375 MIM:605030; AllianceGenome:HGNC:11406 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRS1; MST2 Summary This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues See more Orthologs mouse all