IQGAP2, Official Symbol IQGAP2provided by HGNC Official Full Name IQ motif containing GTPase activating protein 2provided by HGNC Primary source HGNC:HGNC:6111 See related Ensembl:ENSG00000145703 MIM:605401; AllianceGenome:HGNC:6111 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017] Expression Broad expression in liver (RPKM 36.3), duodenum (RPKM 28.2) and 21 other tissues See more Orthologs mouse all