AGXT2, Official Symbol AGXT2provided by HGNC Official Full Name alanine--glyoxylate aminotransferase 2provided by HGNC Primary source HGNC:HGNC:14412 See related Ensembl:ENSG00000113492 MIM:612471; AllianceGenome:HGNC:14412 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGT2; BAIBA; DAIBAT Summary The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Biased expression in kidney (RPKM 69.3) and liver (RPKM 24.9) See more Orthologs mouse all