MIB1, Official Symbol MIB1provided by HGNC Official Full Name MIB E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:21086 See related Ensembl:ENSG00000101752 MIM:608677; AllianceGenome:HGNC:21086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2 Summary This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in thyroid (RPKM 7.2), endometrium (RPKM 6.4) and 25 other tissues See more Orthologs mouse all