CBFA2T3, Official Symbol CBFA2T3provided by HGNC Official Full Name CBFA2/RUNX1 partner transcriptional co-repressor 3provided by HGNC Primary source HGNC:HGNC:1537 See related Ensembl:ENSG00000129993 MIM:603870; AllianceGenome:HGNC:1537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3 Summary This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] Expression Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.7) and 24 other tissues See more Orthologs mouse all