TSSC4, Official Symbol TSSC4provided by HGNC Official Full Name tumor suppressing subtransferable candidate 4provided by HGNC Primary source HGNC:HGNC:12386 See related Ensembl:ENSG00000184281 MIM:603852; AllianceGenome:HGNC:12386 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in testis (RPKM 10.6), bone marrow (RPKM 6.3) and 25 other tissues See more Orthologs mouse all