ARHGEF4, Official Symbol ARHGEF4provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 4provided by HGNC Primary source HGNC:HGNC:684 See related Ensembl:ENSG00000136002 MIM:605216; AllianceGenome:HGNC:684 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASEF; GEF4; STM6; ASEF1; SMIM39 Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013] Expression Biased expression in brain (RPKM 13.8), skin (RPKM 13.1) and 11 other tissues See more Orthologs mouse all