EFR3A, Official Symbol EFR3Aprovided by HGNC Official Full Name EFR3 homolog Aprovided by HGNC Primary source HGNC:HGNC:28970 See related Ensembl:ENSG00000132294 MIM:611798; AllianceGenome:HGNC:28970 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is part of a complex that plays a role in maintaining an active pool of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane. This protein is thought to be a peripheral membrane protein that associates with the plasma membrane through palmitoylation. Studies indicate that this gene product plays a role in controlling G protein-coupled receptor (GPCR) activity by affecting receptor phosphorylation. Whole exome sequencing studies have implicated mutations in this gene with autism spectrum disorders. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in thyroid (RPKM 20.9), brain (RPKM 19.1) and 25 other tissues See more Orthologs mouse all