KCNK2, Official Symbol KCNK2provided by HGNC Official Full Name potassium two pore domain channel subfamily K member 2provided by HGNC Primary source HGNC:HGNC:6277 See related Ensembl:ENSG00000082482 MIM:603219; AllianceGenome:HGNC:6277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e Summary This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue See more Orthologs mouse all