RFX2, Official Symbol RFX2provided by HGNC Official Full Name regulatory factor X2provided by HGNC Primary source HGNC:HGNC:9983 See related Ensembl:ENSG00000087903 MIM:142765; AllianceGenome:HGNC:9983 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 41.1), lung (RPKM 6.6) and 4 other tissues See more Orthologs mouse all