CRAT, Official Symbol CRATprovided by HGNC Official Full Name carnitine O-acetyltransferaseprovided by HGNC Primary source HGNC:HGNC:2342 See related Ensembl:ENSG00000095321 MIM:600184; AllianceGenome:HGNC:2342 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAT; CAT1; NBIA8 Summary This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016] Expression Broad expression in testis (RPKM 76.6), duodenum (RPKM 25.0) and 23 other tissues See more Orthologs mouse all