TPM1, Official Symbol TPM1provided by HGNC Official Full Name tropomyosin 1provided by HGNC Primary source HGNC:HGNC:12010 See related Ensembl:ENSG00000140416 MIM:191010; AllianceGenome:HGNC:12010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha Summary This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022] Expression Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues See more Orthologs mouse all