CLEC7A, Official Symbol CLEC7Aprovided by HGNC Official Full Name C-type lectin domain containing 7Aprovided by HGNC Primary source HGNC:HGNC:14558 See related Ensembl:ENSG00000172243 MIM:606264; AllianceGenome:HGNC:14558 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 22.1), bone marrow (RPKM 11.8) and 17 other tissues See more Orthologs mouse all