OXGR1, Official Symbol OXGR1provided by HGNC Official Full Name oxoglutarate receptor 1provided by HGNC Primary source HGNC:HGNC:4531 See related Ensembl:ENSG00000165621 MIM:606922; AllianceGenome:HGNC:4531 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as aKGR; CAON2; GPR80; GPR99; P2Y15; P2RY15 Summary This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Broad expression in kidney (RPKM 1.0), colon (RPKM 0.6) and 14 other tissues See more Orthologs mouse all