MXD4, Official Symbol MXD4provided by HGNC Official Full Name MAX dimerization protein 4provided by HGNC Primary source HGNC:HGNC:13906 See related Ensembl:ENSG00000123933 MIM:620016; AllianceGenome:HGNC:13906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAD4; MST149; MSTP149; bHLHc12 Summary This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 22.9), spleen (RPKM 18.5) and 25 other tissues See more Orthologs mouse all