MMP12, Official Symbol MMP12provided by HGNC Official Full Name matrix metallopeptidase 12provided by HGNC Primary source HGNC:HGNC:7158 See related Ensembl:ENSG00000262406 MIM:601046; AllianceGenome:HGNC:7158 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ME; HME; MME; MMP-12 Summary This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016] Expression Biased expression in appendix (RPKM 25.3), urinary bladder (RPKM 15.0) and 7 other tissues See more Orthologs mouse all