EPHB3, Official Symbol EPHB3provided by HGNC Official Full Name EPH receptor B3provided by HGNC Primary source HGNC:HGNC:3394 See related Ensembl:ENSG00000182580 MIM:601839; AllianceGenome:HGNC:3394 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EK2; ETK2; HEK2; TYRO6 Summary Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010] Expression Broad expression in skin (RPKM 18.6), stomach (RPKM 10.2) and 15 other tissues See more Orthologs mouse all