HRK, Official Symbol HRKprovided by HGNC Official Full Name harakiri, BCL2 interacting proteinprovided by HGNC Primary source HGNC:HGNC:5185 See related Ensembl:ENSG00000135116 MIM:603447; AllianceGenome:HGNC:5185 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DP5; HARAKIRI Summary This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] Expression Biased expression in brain (RPKM 5.1), thyroid (RPKM 2.9) and 3 other tissues See more Orthologs mouse all