HTR2A, Official Symbol HTR2Aprovided by HGNC Official Full Name 5-hydroxytryptamine receptor 2Aprovided by HGNC Primary source HGNC:HGNC:5293 See related Ensembl:ENSG00000102468 MIM:182135; AllianceGenome:HGNC:5293 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTR2; 5-HT2A Summary This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Biased expression in brain (RPKM 11.8) and gall bladder (RPKM 0.8) See more Orthologs mouse all