GMPS, Official Symbol GMPSprovided by HGNC Official Full Name guanine monophosphate synthaseprovided by HGNC Primary source HGNC:HGNC:4378 See related Ensembl:ENSG00000163655 MIM:600358; AllianceGenome:HGNC:4378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GATD7 Summary In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 20.3), thyroid (RPKM 6.3) and 25 other tissues See more Orthologs mouse all