CYB5A, Official Symbol CYB5Aprovided by HGNC Official Full Name cytochrome b5 type Aprovided by HGNC Primary source HGNC:HGNC:2570 See related Ensembl:ENSG00000166347 MIM:613218; AllianceGenome:HGNC:2570 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYB5; MCB5; METAG Summary The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Expression Broad expression in liver (RPKM 226.1), kidney (RPKM 141.0) and 16 other tissues See more Orthologs mouse all