BAG1, Official Symbol BAG1provided by HGNC Official Full Name BAG cochaperone 1provided by HGNC Primary source HGNC:HGNC:937 See related Ensembl:ENSG00000107262 MIM:601497; AllianceGenome:HGNC:937 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAP; BAG-1; RAP46 Summary The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010] Expression Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues See more Orthologs mouse all