EEF1E1, Official Symbol EEF1E1provided by HGNC Official Full Name eukaryotic translation elongation factor 1 epsilon 1provided by HGNC Primary source HGNC:HGNC:3212 See related Ensembl:ENSG00000124802 MIM:609206; AllianceGenome:HGNC:3212 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P18; AIMP3 Summary This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in testis (RPKM 14.5), kidney (RPKM 11.4) and 25 other tissues See more Orthologs mouse all