ARF6, Official Symbol ARF6provided by HGNC Official Full Name ADP ribosylation factor 6provided by HGNC Primary source HGNC:HGNC:659 See related Ensembl:ENSG00000165527 MIM:600464; AllianceGenome:HGNC:659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 54.5), colon (RPKM 38.8) and 25 other tissues See more Orthologs mouse all