ACTR1A, Official Symbol ACTR1Aprovided by HGNC Official Full Name actin related protein 1Aprovided by HGNC Primary source HGNC:HGNC:167 See related Ensembl:ENSG00000138107 MIM:605143; AllianceGenome:HGNC:167 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARP1; Arp1A; CTRN1 Summary This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 46.1), heart (RPKM 30.0) and 25 other tissues See more Orthologs mouse all