TRPC4, Official Symbol TRPC4provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 4provided by HGNC Primary source HGNC:HGNC:12336 See related Ensembl:ENSG00000133107 MIM:603651; AllianceGenome:HGNC:12336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP4; HTRP4; HTRP-4 Summary This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] Expression Biased expression in endometrium (RPKM 6.2), prostate (RPKM 2.5) and 8 other tissues See more Orthologs mouse all