SEMA3E, Official Symbol SEMA3Eprovided by HGNC Official Full Name semaphorin 3Eprovided by HGNC Primary source HGNC:HGNC:10727 See related Ensembl:ENSG00000170381 MIM:608166; AllianceGenome:HGNC:10727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEMAH; coll-5; M-SEMAH; M-SemaK Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] Expression Biased expression in brain (RPKM 3.1), gall bladder (RPKM 2.2) and 13 other tissues See more Orthologs mouse all