GTPBP4, Official Symbol GTPBP4provided by HGNC Official Full Name GTP binding protein 4provided by HGNC Primary source HGNC:HGNC:21535 See related Ensembl:ENSG00000107937 MIM:619169; AllianceGenome:HGNC:21535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NGB; CRFG; NOG1 Summary GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 19.5), testis (RPKM 18.5) and 25 other tissues See more Orthologs mouse all