PRC1, Official Symbol PRC1provided by HGNC Official Full Name protein regulator of cytokinesis 1provided by HGNC Primary source HGNC:HGNC:9341 See related Ensembl:ENSG00000198901 MIM:603484; AllianceGenome:HGNC:9341 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASE1 Summary This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Expression Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more Orthologs mouse all