P2RY2, Official Symbol P2RY2provided by HGNC Official Full Name purinergic receptor P2Y2provided by HGNC Primary source HGNC:HGNC:8541 See related Ensembl:ENSG00000175591 MIM:600041; AllianceGenome:HGNC:8541 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R Summary The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013] Expression Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more Orthologs mouse all