SERPIND1, Official Symbol SERPIND1provided by HGNC Official Full Name serpin family D member 1provided by HGNC Primary source HGNC:HGNC:4838 See related Ensembl:ENSG00000099937 MIM:142360; AllianceGenome:HGNC:4838 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673 Summary This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015] Expression Restricted expression toward liver (RPKM 330.2) See more Orthologs mouse all