RNF123, Official Symbol RNF123provided by HGNC Official Full Name ring finger protein 123provided by HGNC Primary source HGNC:HGNC:21148 See related Ensembl:ENSG00000164068 MIM:614472; AllianceGenome:HGNC:21148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KPC1; FP1477 Summary The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in bone marrow (RPKM 13.6), testis (RPKM 10.9) and 25 other tissues See more Orthologs mouse all