CHRM1, Official Symbol CHRM1provided by HGNC Official Full Name cholinergic receptor muscarinic 1provided by HGNC Primary source HGNC:HGNC:1950 See related Ensembl:ENSG00000168539 MIM:118510; AllianceGenome:HGNC:1950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M1; HM1; M1R Summary The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 24.3), brain (RPKM 18.2) and 4 other tissues See more Orthologs mouse all