SIRPB1, Official Symbol SIRPB1provided by HGNC Official Full Name signal regulatory protein beta 1provided by HGNC Primary source HGNC:HGNC:15928 See related Ensembl:ENSG00000101307 MIM:603889; AllianceGenome:HGNC:15928 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD172b; SIRP-BETA-1 Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] Expression Broad expression in appendix (RPKM 6.6), bone marrow (RPKM 6.0) and 22 other tissues See more Orthologs all