FAP, Official Symbol FAPprovided by HGNC Official Full Name fibroblast activation protein alphaprovided by HGNC Primary source HGNC:HGNC:3590 See related Ensembl:ENSG00000078098 MIM:600403; AllianceGenome:HGNC:3590 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAPA; SIMP; DPPIV; FAPalpha Summary The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] Expression Biased expression in endometrium (RPKM 7.5), gall bladder (RPKM 5.1) and 11 other tissues See more Orthologs mouse all