EPSTI1, Official Symbol EPSTI1provided by HGNC Official Full Name epithelial stromal interaction 1provided by HGNC Primary source HGNC:HGNC:16465 See related Ensembl:ENSG00000133106 MIM:607441; AllianceGenome:HGNC:16465 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRESI1 Summary The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016] Expression Broad expression in lymph node (RPKM 5.8), spleen (RPKM 5.8) and 23 other tissues See more Orthologs mouse all