EDAR, Official Symbol EDARprovided by HGNC Official Full Name ectodysplasin A receptorprovided by HGNC Primary source HGNC:HGNC:2895 See related Ensembl:ENSG00000135960 MIM:604095; AllianceGenome:HGNC:2895 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R Summary This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 1.4), lymph node (RPKM 0.8) and 18 other tissues See more Orthologs mouse all