NLRP11, Official Symbol NLRP11provided by HGNC Official Full Name NLR family pyrin domain containing 11provided by HGNC Primary source HGNC:HGNC:22945 See related Ensembl:ENSG00000179873 MIM:609664; AllianceGenome:HGNC:22945 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6 Summary This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017] Expression Low expression observed in reference dataset See more Orthologs all