FRMPD2, Official Symbol FRMPD2provided by HGNC Official Full Name FERM and PDZ domain containing 2provided by HGNC Primary source HGNC:HGNC:28572 See related Ensembl:ENSG00000170324 MIM:613323; AllianceGenome:HGNC:28572 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDZK4; PDZD5C; PDZK5C Summary This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009] Expression Biased expression in brain (RPKM 2.2), testis (RPKM 1.3) and 4 other tissues See more Orthologs mouse all