IL10RA, Official Symbol IL10RAprovided by HGNC Official Full Name interleukin 10 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:5964 See related Ensembl:ENSG00000110324 MIM:146933; AllianceGenome:HGNC:5964 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1 Summary The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] Expression Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more Orthologs mouse all