DDX27, Official Symbol DDX27provided by HGNC Official Full Name DEAD-box helicase 27provided by HGNC Primary source HGNC:HGNC:15837 See related Ensembl:ENSG00000124228 MIM:616621; AllianceGenome:HGNC:15837 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRS1; RHLP; Drs1p; PP3241; HSPC259; dJ686N3.1 Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in testis (RPKM 18.7), lymph node (RPKM 16.9) and 25 other tissues See more Orthologs mouse all