DSPP, Official Symbol DSPPprovided by HGNC Official Full Name dentin sialophosphoproteinprovided by HGNC Primary source HGNC:HGNC:3054 See related Ensembl:ENSG00000152591 MIM:125485; AllianceGenome:HGNC:3054 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPP; DSP; DGI1; DMP3; DFNA39 Summary This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Low expression observed in reference dataset See more Orthologs mouse all