PTPRG, Official Symbol PTPRGprovided by HGNC Official Full Name protein tyrosine phosphatase receptor type Gprovided by HGNC Primary source HGNC:HGNC:9671 See related Ensembl:ENSG00000144724 MIM:176886; AllianceGenome:HGNC:9671 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTPG; HPTPG; RPTPG; R-PTP-GAMMA Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 11.5), kidney (RPKM 9.0) and 23 other tissues See more Orthologs mouse all