CCHCR1, Official Symbol CCHCR1provided by HGNC Official Full Name coiled-coil alpha-helical rod protein 1provided by HGNC Primary source HGNC:HGNC:13930 See related Ensembl:ENSG00000204536 MIM:605310; AllianceGenome:HGNC:13930 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCR; SBP; pg8; C6orf18 Summary This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Broad expression in testis (RPKM 37.2), prostate (RPKM 4.5) and 18 other tissues See more Orthologs mouse all