PLCB2, Official Symbol PLCB2provided by HGNC Official Full Name phospholipase C beta 2provided by HGNC Primary source HGNC:HGNC:9055 See related Ensembl:ENSG00000137841 MIM:604114; AllianceGenome:HGNC:9055 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLC-beta-2 Summary The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017] Expression Broad expression in spleen (RPKM 26.9), bone marrow (RPKM 19.8) and 17 other tissues See more Orthologs mouse all