RGS2, Official Symbol RGS2provided by HGNC Official Full Name regulator of G protein signaling 2provided by HGNC Primary source HGNC:HGNC:9998 See related Ensembl:ENSG00000116741 MIM:600861; AllianceGenome:HGNC:9998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G0S8 Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] Expression Broad expression in bone marrow (RPKM 211.2), adrenal (RPKM 208.4) and 20 other tissues See more Orthologs mouse all