PDCD1, Official Symbol PDCD1provided by HGNC Official Full Name programmed cell death 1provided by HGNC Primary source HGNC:HGNC:8760 See related Ensembl:ENSG00000188389 MIM:600244; AllianceGenome:HGNC:8760 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1 Summary Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] Expression Biased expression in lymph node (RPKM 8.8), spleen (RPKM 2.6) and 7 other tissues See more Orthologs mouse all