HABP2, Official Symbol HABP2provided by HGNC Official Full Name hyaluronan binding protein 2provided by HGNC Primary source HGNC:HGNC:4798 See related Ensembl:ENSG00000148702 MIM:603924; AllianceGenome:HGNC:4798 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FSAP; HABP; PHBP; HGFAL; NMTC5 Summary This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 158.0), gall bladder (RPKM 23.3) and 1 other tissue See more Orthologs mouse all