BAG6, Official Symbol BAG6provided by HGNC Official Full Name BAG cochaperone 6provided by HGNC Primary source HGNC:HGNC:13919 See related Ensembl:ENSG00000204463 MIM:142590; AllianceGenome:HGNC:13919 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G3; BAT3; BAG-6; D6S52E Summary This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 77.2), spleen (RPKM 25.1) and 25 other tissues See more Orthologs mouse all