PARS2, Official Symbol PARS2provided by HGNC Official Full Name prolyl-tRNA synthetase 2, mitochondrialprovided by HGNC Primary source HGNC:HGNC:30563 See related Ensembl:ENSG00000162396 MIM:612036; AllianceGenome:HGNC:30563 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE75; proRS; EIEE75; MT-PRORS Summary This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015] Expression Ubiquitous expression in testis (RPKM 3.4), ovary (RPKM 2.8) and 24 other tissues See more Orthologs mouse all