USP27X, Official Symbol USP27Xprovided by HGNC Official Full Name ubiquitin specific peptidase 27 X-linkedprovided by HGNC Primary source HGNC:HGNC:13486 See related Ensembl:ENSG00000273820 MIM:300975; AllianceGenome:HGNC:13486 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP27; MRX105; USP22L; XLID105 Summary This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016] Orthologs mouse all