IGFBP2, Official Symbol IGFBP2provided by HGNC Official Full Name insulin like growth factor binding protein 2provided by HGNC Primary source HGNC:HGNC:5471 See related Ensembl:ENSG00000115457 MIM:146731; AllianceGenome:HGNC:5471 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IBP2; IGF-BP53 Summary The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015] Expression Broad expression in liver (RPKM 67.6), stomach (RPKM 67.2) and 20 other tissues See more Orthologs mouse all