MFGE8, Official Symbol MFGE8provided by HGNC Official Full Name milk fat globule EGF and factor V/VIII domain containingprovided by HGNC Primary source HGNC:HGNC:7036 See related Ensembl:ENSG00000140545 MIM:602281; AllianceGenome:HGNC:7036 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888 Summary This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Broad expression in heart (RPKM 68.1), endometrium (RPKM 47.7) and 22 other tissues See more Orthologs mouse all