SIX3, Official Symbol SIX3provided by HGNC Official Full Name SIX homeobox 3provided by HGNC Primary source HGNC:HGNC:10889 See related Ensembl:ENSG00000138083 MIM:603714; AllianceGenome:HGNC:10889 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPE2 Summary This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all