USP49, Official Symbol USP49provided by HGNC Official Full Name ubiquitin specific peptidase 49provided by HGNC Primary source HGNC:HGNC:20078 See related Ensembl:ENSG00000164663 AllianceGenome:HGNC:20078 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent deubiquitinase. Involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.1), thyroid (RPKM 1.8) and 25 other tissues See more Orthologs mouse all