SEM1, Official Symbol SEM1provided by HGNC Official Full Name SEM1 26S proteasome subunitprovided by HGNC Primary source HGNC:HGNC:10845 See related Ensembl:ENSG00000127922 MIM:601285; AllianceGenome:HGNC:10845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ECD; DSS1; SHFD1; SHFM1; SHSF1; PSMD15; Shfdg1; C7orf76 Summary The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 89.9), colon (RPKM 83.9) and 25 other tissues See more Orthologs mouse all