EPHA1, Official Symbol EPHA1provided by HGNC Official Full Name EPH receptor A1provided by HGNC Primary source HGNC:HGNC:3385 See related Ensembl:ENSG00000146904 MIM:179610; AllianceGenome:HGNC:3385 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPH; EPHT; EPHT1 Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 21.6), skin (RPKM 11.4) and 25 other tissues See more Orthologs mouse all