TNFRSF18, Official Symbol TNFRSF18provided by HGNC Official Full Name TNF receptor superfamily member 18provided by HGNC Primary source HGNC:HGNC:11914 See related Ensembl:ENSG00000186891 MIM:603905; AllianceGenome:HGNC:11914 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AITR; GITR; CD357; GITR-D; ENERGEN Summary This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] Expression Biased expression in skin (RPKM 4.0), appendix (RPKM 1.0) and 12 other tissues See more Orthologs mouse all