TAX1BP1, Official Symbol TAX1BP1provided by HGNC Official Full Name Tax1 binding protein 1provided by HGNC Primary source HGNC:HGNC:11575 See related Ensembl:ENSG00000106052 MIM:605326; AllianceGenome:HGNC:11575 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T6BP; TXBP151; CALCOCO3 Summary This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] Expression Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues See more Orthologs mouse all