SELPLG, Official Symbol SELPLGprovided by HGNC Official Full Name selectin P ligandprovided by HGNC Primary source HGNC:HGNC:10722 See related Ensembl:ENSG00000110876 MIM:600738; AllianceGenome:HGNC:10722 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLA; CD162; PSGL1; PSGL-1 Summary This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] Expression Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues See more Orthologs mouse all