DOCK6, Official Symbol DOCK6provided by HGNC Official Full Name dedicator of cytokinesis 6provided by HGNC Primary source HGNC:HGNC:19189 See related Ensembl:ENSG00000130158 MIM:614194; AllianceGenome:HGNC:19189 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AOS2; ZIR1 Summary This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in fat (RPKM 16.5), lung (RPKM 12.6) and 24 other tissues See more Orthologs mouse all