MCM10, Official Symbol MCM10provided by HGNC Official Full Name minichromosome maintenance 10 replication initiation factorprovided by HGNC Primary source HGNC:HGNC:18043 See related Ensembl:ENSG00000065328 MIM:609357; AllianceGenome:HGNC:18043 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNA43; DNA43; IMD80; PRO2249 Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues See more Orthologs mouse all