SCN1B, Official Symbol SCN1Bprovided by HGNC Official Full Name sodium voltage-gated channel beta subunit 1provided by HGNC Primary source HGNC:HGNC:10586 See related Ensembl:ENSG00000105711 MIM:600235; AllianceGenome:HGNC:10586 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE52; ATFB13; BRGDA5; EIEE52; GEFSP1 Summary Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Expression Broad expression in heart (RPKM 5.3), brain (RPKM 5.1) and 21 other tissues See more Orthologs mouse all