PPME1, Official Symbol PPME1provided by HGNC Official Full Name protein phosphatase methylesterase 1provided by HGNC Primary source HGNC:HGNC:30178 See related Ensembl:ENSG00000214517 MIM:611117; AllianceGenome:HGNC:30178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PME-1; ABDH19 Summary This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 17.5) and 25 other tissues See more Orthologs mouse all