NHEJ1, Official Symbol NHEJ1provided by HGNC Official Full Name non-homologous end joining factor 1provided by HGNC Primary source HGNC:HGNC:25737 See related Ensembl:ENSG00000187736 MIM:611290; AllianceGenome:HGNC:25737 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XLF Summary Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 11.1), colon (RPKM 7.7) and 25 other tissues See more Orthologs mouse all