NCF2, Official Symbol NCF2provided by HGNC Official Full Name neutrophil cytosolic factor 2provided by HGNC Primary source HGNC:HGNC:7661 See related Ensembl:ENSG00000116701 MIM:608515; AllianceGenome:HGNC:7661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCF-2; NOXA2; P67PHOX; P67-PHOX Summary This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] Expression Broad expression in bone marrow (RPKM 41.9), appendix (RPKM 36.2) and 15 other tissues See more Orthologs mouse all