RUNX1T1, Official Symbol RUNX1T1provided by HGNC Official Full Name RUNX1 partner transcriptional co-repressor 1provided by HGNC Primary source HGNC:HGNC:1535 See related Ensembl:ENSG00000079102 MIM:133435; AllianceGenome:HGNC:1535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8 Summary This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in endometrium (RPKM 1.9), brain (RPKM 1.3) and 22 other tissues See more Orthologs mouse all