CREB3, Official Symbol CREB3provided by HGNC Official Full Name cAMP responsive element binding protein 3provided by HGNC Primary source HGNC:HGNC:2347 See related Ensembl:ENSG00000107175 MIM:606443; AllianceGenome:HGNC:2347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LZIP; LUMAN; sLZIP Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009] Expression Ubiquitous expression in prostate (RPKM 27.8), testis (RPKM 25.9) and 25 other tissues See more Orthologs mouse all