CRYL1, Official Symbol CRYL1provided by HGNC Official Full Name crystallin lambda 1provided by HGNC Primary source HGNC:HGNC:18246 See related Ensembl:ENSG00000165475 MIM:609877; AllianceGenome:HGNC:18246 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDH; HEL30; gul3DH; lambda-CRY Summary The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 110.5), duodenum (RPKM 59.6) and 21 other tissues See more Orthologs mouse all