MTHFD1L, Official Symbol MTHFD1Lprovided by HGNC Official Full Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by HGNC Primary source HGNC:HGNC:21055 See related Ensembl:ENSG00000120254 MIM:611427; AllianceGenome:HGNC:21055 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTHFSDC1; MTC1THFS; dJ292B18.2 Summary The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] Expression Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.0) and 25 other tissues See more Orthologs mouse all