CCL21, Official Symbol CCL21provided by HGNC Official Full Name C-C motif chemokine ligand 21provided by HGNC Primary source HGNC:HGNC:10620 See related Ensembl:ENSG00000137077 MIM:602737; AllianceGenome:HGNC:10620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21 Summary This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014] Expression Biased expression in lymph node (RPKM 1020.3), spleen (RPKM 170.8) and 2 other tissues See more Orthologs mouse all