HLF, Official Symbol HLFprovided by HGNC Official Full Name HLF transcription factor, PAR bZIP family memberprovided by HGNC Primary source HGNC:HGNC:4977 See related Ensembl:ENSG00000108924 MIM:142385; AllianceGenome:HGNC:4977 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 22.6), brain (RPKM 22.4) and 18 other tissues See more Orthologs mouse all