IGF2BP3, Official Symbol IGF2BP3provided by HGNC Official Full Name insulin like growth factor 2 mRNA binding protein 3provided by HGNC Primary source HGNC:HGNC:28868 See related Ensembl:ENSG00000136231 MIM:608259; AllianceGenome:HGNC:28868 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3 Summary The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008] Annotation information Note: IMP3 (Gene ID: 55272) and IGF2BP3 (Gene ID: 10643) share the IMP3 symbol/alias in common. IMP3 is a widely used alternative name for insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), which can be confused with the official symbol for IMP3, U3 small nucleolar ribonucleoprotein (IMP3). [17 May 2018] Expression Biased expression in placenta (RPKM 12.9), testis (RPKM 2.5) and 2 other tissues See more Orthologs mouse all