PAFAH2, Official Symbol PAFAH2provided by HGNC Official Full Name platelet activating factor acetylhydrolase 2provided by HGNC Primary source HGNC:HGNC:8579 See related Ensembl:ENSG00000158006 MIM:602344; AllianceGenome:HGNC:8579 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSD-PLA2 Summary This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 8.5), colon (RPKM 7.9) and 25 other tissues See more Orthologs mouse all