UNC5C, Official Symbol UNC5Cprovided by HGNC Official Full Name unc-5 netrin receptor Cprovided by HGNC Primary source HGNC:HGNC:12569 See related Ensembl:ENSG00000182168 MIM:603610; AllianceGenome:HGNC:12569 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC5H3 Summary This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues See more Orthologs mouse all