ARFGEF1, Official Symbol ARFGEF1provided by HGNC Official Full Name ADP ribosylation factor guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:15772 See related Ensembl:ENSG00000066777 MIM:604141; AllianceGenome:HGNC:15772 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIG1; P200; DEDISB; ARFGEP1 Summary ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in testis (RPKM 17.7), thyroid (RPKM 13.6) and 25 other tissues See more Orthologs mouse all