TLE3, Official Symbol TLE3provided by HGNC Official Full Name TLE family member 3, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11839 See related Ensembl:ENSG00000140332 MIM:600190; AllianceGenome:HGNC:11839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; ESG3; GRG3; HsT18976 Summary This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more Orthologs mouse all