CYP51A1, Official Symbol CYP51A1provided by HGNC Official Full Name cytochrome P450 family 51 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2649 See related Ensembl:ENSG00000001630 MIM:601637; AllianceGenome:HGNC:2649 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Broad expression in liver (RPKM 53.6), testis (RPKM 45.9) and 25 other tissues See more Orthologs mouse all