MAD1L1, Official Symbol MAD1L1provided by HGNC Official Full Name mitotic arrest deficient 1 like 1provided by HGNC Primary source HGNC:HGNC:6762 See related Ensembl:ENSG00000002822 MIM:602686; AllianceGenome:HGNC:6762 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAD1; MVA7; PIG9; TP53I9; TXBP181 Summary MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in testis (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues See more Orthologs mouse all