AARS1, Official Symbol AARS1provided by HGNC Official Full Name alanyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:20 See related Ensembl:ENSG00000090861 MIM:601065; AllianceGenome:HGNC:20 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AARS; TTD8; CMT2N; DEE29; HDLS2; EIEE29 Summary The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 59.4), thyroid (RPKM 56.4) and 25 other tissues See more Orthologs mouse all