ACMSD, Official Symbol ACMSDprovided by HGNC Official Full Name aminocarboxymuconate semialdehyde decarboxylaseprovided by HGNC Primary source HGNC:HGNC:19288 See related Ensembl:ENSG00000153086 MIM:608889; AllianceGenome:HGNC:19288 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004] Expression Biased expression in kidney (RPKM 17.3), liver (RPKM 10.7) and 1 other tissue See more Orthologs mouse all