KRT16, Official Symbol KRT16provided by HGNC Official Full Name keratin 16provided by HGNC Primary source HGNC:HGNC:6423 See related Ensembl:ENSG00000186832 MIM:148067; AllianceGenome:HGNC:6423 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A Summary The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 209.9) and esophagus (RPKM 198.8) See more Orthologs mouse all