SYK, Official Symbol SYKprovided by HGNC Official Full Name spleen associated tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:11491 See related Ensembl:ENSG00000165025 MIM:600085; AllianceGenome:HGNC:11491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD82; p72-Syk Summary This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Broad expression in lymph node (RPKM 32.4), appendix (RPKM 24.8) and 20 other tissues See more Orthologs mouse all