ITIH3, Official Symbol ITIH3provided by HGNC Official Full Name inter-alpha-trypsin inhibitor heavy chain 3provided by HGNC Primary source HGNC:HGNC:6168 See related Ensembl:ENSG00000162267 MIM:146650; AllianceGenome:HGNC:6168 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H3P; SHAP; ITI-HC3 Summary This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015] Expression Restricted expression toward liver (RPKM 228.8) See more Orthologs mouse all