INSIG2, Official Symbol INSIG2provided by HGNC Official Full Name insulin induced gene 2provided by HGNC Primary source HGNC:HGNC:20452 See related Ensembl:ENSG00000125629 MIM:608660; AllianceGenome:HGNC:20452 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INSIG-2 Summary The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 12.3), lung (RPKM 10.5) and 25 other tissues See more Orthologs mouse all