LRRK1, Official Symbol LRRK1provided by HGNC Official Full Name leucine rich repeat kinase 1provided by HGNC Primary source HGNC:HGNC:18608 See related Ensembl:ENSG00000154237 MIM:610986; AllianceGenome:HGNC:18608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSMD; RIPK6; Roco1 Summary This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in lymph node (RPKM 6.0), spleen (RPKM 4.4) and 24 other tissues See more Orthologs mouse all