NFKBIE, Official Symbol NFKBIEprovided by HGNC Official Full Name NFKB inhibitor epsilonprovided by HGNC Primary source HGNC:HGNC:7799 See related Ensembl:ENSG00000146232 MIM:604548; AllianceGenome:HGNC:7799 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKBE Summary The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011] Expression Broad expression in bone marrow (RPKM 9.4), spleen (RPKM 9.3) and 25 other tissues See more Orthologs mouse all