EIF4G3, Official Symbol EIF4G3provided by HGNC Official Full Name eukaryotic translation initiation factor 4 gamma 3provided by HGNC Primary source HGNC:HGNC:3298 See related Ensembl:ENSG00000075151 MIM:603929; AllianceGenome:HGNC:3298 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eIF4G 3; eIF4GII; eIF-4G 3 Summary The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016] Expression Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues See more Orthologs mouse all