BCR, Official Symbol BCRprovided by HGNC Official Full Name BCR activator of RhoGEF and GTPaseprovided by HGNC Primary source HGNC:HGNC:1014 See related Ensembl:ENSG00000186716 MIM:151410; AllianceGenome:HGNC:1014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALL; CML; PHL; BCR1; D22S11; D22S662 Summary A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020] Expression Ubiquitous expression in testis (RPKM 14.9), brain (RPKM 14.5) and 25 other tissues See more Orthologs mouse all