BMP8B, Official Symbol BMP8Bprovided by HGNC Official Full Name bone morphogenetic protein 8bprovided by HGNC Primary source HGNC:HGNC:1075 See related Ensembl:ENSG00000116985 MIM:602284; AllianceGenome:HGNC:1075 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OP2; BMP8 Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016] Expression Broad expression in thyroid (RPKM 7.4), adrenal (RPKM 2.8) and 20 other tissues See more Orthologs mouse all