SEC61B, Official Symbol SEC61Bprovided by HGNC Official Full Name SEC61 translocon subunit betaprovided by HGNC Primary source HGNC:HGNC:16993 See related Ensembl:ENSG00000106803 MIM:609214; AllianceGenome:HGNC:16993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 68.2), appendix (RPKM 66.5) and 25 other tissues See more Orthologs mouse all