PRMT5, Official Symbol PRMT5provided by HGNC Official Full Name protein arginine methyltransferase 5provided by HGNC Primary source HGNC:HGNC:10894 See related Ensembl:ENSG00000100462 MIM:604045; AllianceGenome:HGNC:10894 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSL7; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5 Summary This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in thyroid (RPKM 21.2), ovary (RPKM 18.5) and 25 other tissues See more Orthologs mouse all