COMMD1, Official Symbol COMMD1provided by HGNC Official Full Name copper metabolism domain containing 1provided by HGNC Primary source HGNC:HGNC:23024 See related Ensembl:ENSG00000173163 MIM:607238; AllianceGenome:HGNC:23024 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MURR1; C2orf5 Summary Enables several functions, including phosphatidylinositol-3,4-bisphosphate binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including Golgi to plasma membrane transport; negative regulation of protein localization to cell surface; and regulation of cellular protein metabolic process. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity. Located in cytosol; endosome; and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 5.7), testis (RPKM 5.6) and 25 other tissues See more Orthologs mouse all