ZBTB7B, Official Symbol ZBTB7Bprovided by HGNC Official Full Name zinc finger and BTB domain containing 7Bprovided by HGNC Primary source HGNC:HGNC:18668 See related Ensembl:ENSG00000160685 MIM:607646; AllianceGenome:HGNC:18668 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as vGAF; CKROX; THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857B Summary This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in skin (RPKM 39.5), duodenum (RPKM 31.2) and 25 other tissues See more Orthologs mouse all