APBB2, Official Symbol APBB2provided by HGNC Official Full Name amyloid beta precursor protein binding family B member 2provided by HGNC Primary source HGNC:HGNC:582 See related Ensembl:ENSG00000163697 MIM:602710; AllianceGenome:HGNC:582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FE65L; FE65L1 Summary The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in fat (RPKM 13.0), thyroid (RPKM 11.7) and 24 other tissues See more Orthologs mouse all