ASCC1, Official Symbol ASCC1provided by HGNC Official Full Name activating signal cointegrator 1 complex subunit 1provided by HGNC Primary source HGNC:HGNC:24268 See related Ensembl:ENSG00000138303 MIM:614215; AllianceGenome:HGNC:24268 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p50; CGI-18; SMABF2; ASC1p50 Summary This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in testis (RPKM 7.6), brain (RPKM 6.4) and 25 other tissues See more Orthologs mouse all