PLAGL1, Official Symbol PLAGL1provided by HGNC Official Full Name PLAG1 like zinc finger 1provided by HGNC Primary source HGNC:HGNC:9046 See related Ensembl:ENSG00000118495 MIM:603044; AllianceGenome:HGNC:9046 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZAC; LOT1; ZAC1 Summary This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015] Expression Broad expression in placenta (RPKM 68.4), skin (RPKM 15.8) and 16 other tissues See more Orthologs mouse all