PRAM1, Official Symbol PRAM1provided by HGNC Official Full Name PML-RARA regulated adaptor molecule 1provided by HGNC Primary source HGNC:HGNC:30091 See related Ensembl:ENSG00000133246 MIM:606466; AllianceGenome:HGNC:30091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAM-1; PML-RAR Summary The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues See more Orthologs mouse all