ALDH1A2, Official Symbol ALDH1A2provided by HGNC Official Full Name aldehyde dehydrogenase 1 family member A2provided by HGNC Primary source HGNC:HGNC:15472 See related Ensembl:ENSG00000128918 MIM:603687; AllianceGenome:HGNC:15472 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIH4; RALDH2; RALDH2-T; RALDH(II) Summary This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011] Expression Biased expression in endometrium (RPKM 50.6), testis (RPKM 38.7) and 8 other tissues See more Orthologs mouse all