ACKR2, Official Symbol ACKR2provided by HGNC Official Full Name atypical chemokine receptor 2provided by HGNC Primary source HGNC:HGNC:1565 See related Ensembl:ENSG00000144648 MIM:602648; AllianceGenome:HGNC:1565 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D6; hD6; CCR9; CCBP2; CCR10; CMKBR9 Summary This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 6.7), liver (RPKM 1.2) and 9 other tissues See more Orthologs mouse all