PDPK1, Official Symbol PDPK1provided by HGNC Official Full Name 3-phosphoinositide dependent protein kinase 1provided by HGNC Primary source HGNC:HGNC:8816 See related Ensembl:ENSG00000140992 MIM:605213; AllianceGenome:HGNC:8816 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDK1; PDPK2; PDPK2P; PRO0461 Summary Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018] Expression Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues See more Orthologs mouse all