HUWE1, Official Symbol HUWE1provided by HGNC Official Full Name HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:30892 See related Ensembl:ENSG00000086758 MIM:300697; AllianceGenome:HGNC:30892 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MULE; Ib772; LASU1; MRXST; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272 Summary This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in ovary (RPKM 14.5), testis (RPKM 13.8) and 25 other tissues See more Orthologs mouse all