FUS, Official Symbol FUSprovided by HGNC Official Full Name FUS RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:4010 See related Ensembl:ENSG00000089280 MIM:137070; AllianceGenome:HGNC:4010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLS; ALS6; ETM4; FUS1; POMP75; altFUS; HNRNPP2 Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in appendix (RPKM 32.4), lymph node (RPKM 29.5) and 25 other tissues See more Orthologs mouse all