KCNIP3, Official Symbol KCNIP3provided by HGNC Official Full Name potassium voltage-gated channel interacting protein 3provided by HGNC Primary source HGNC:HGNC:15523 See related Ensembl:ENSG00000115041 MIM:604662; AllianceGenome:HGNC:15523 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSEN; DREAM; KCHIP3 Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 13.6), thyroid (RPKM 9.3) and 14 other tissues See more Orthologs mouse all