PLK3, Official Symbol PLK3provided by HGNC Official Full Name polo like kinase 3provided by HGNC Primary source HGNC:HGNC:2154 See related Ensembl:ENSG00000173846 MIM:602913; AllianceGenome:HGNC:2154 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNK; FNK; PRK; PLK-3 Summary The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in bone marrow (RPKM 16.1), gall bladder (RPKM 12.7) and 25 other tissues See more Orthologs mouse all