DSG2, Official Symbol DSG2provided by HGNC Official Full Name desmoglein 2provided by HGNC Primary source HGNC:HGNC:3049 See related Ensembl:ENSG00000046604 MIM:125671; AllianceGenome:HGNC:3049 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HDGC; CDHF5 Summary This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016] Expression Broad expression in colon (RPKM 71.0), small intestine (RPKM 46.2) and 18 other tissues See more Orthologs mouse all