SYCE1, Official Symbol SYCE1provided by HGNC Official Full Name synaptonemal complex central element protein 1provided by HGNC Primary source HGNC:HGNC:28852 See related Ensembl:ENSG00000171772 MIM:611486; AllianceGenome:HGNC:28852 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT76; POF12; SPGF15; C10orf94 Summary This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] Expression Biased expression in testis (RPKM 31.6), placenta (RPKM 4.3) and 1 other tissue See more Orthologs mouse all