CHMP4A, Official Symbol CHMP4Aprovided by HGNC Official Full Name charged multivesicular body protein 4Aprovided by HGNC Primary source HGNC:HGNC:20274 See related Ensembl:ENSG00000254505 MIM:610051; AllianceGenome:HGNC:20274 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNF7; CHMP4; SHAX2; CHMP4B; SNF7-1; VPS32A; HSPC134; VPS32-1; hSnf7-1; C14orf123 Summary CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in fat (RPKM 27.3), lymph node (RPKM 25.9) and 25 other tissues See more Orthologs all