OSTM1, Official Symbol OSTM1provided by HGNC Official Full Name osteoclastogenesis associated transmembrane protein 1provided by HGNC Primary source HGNC:HGNC:21652 See related Ensembl:ENSG00000081087 MIM:607649; AllianceGenome:HGNC:21652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GL; GIPN; OPTB5; HSPC019 Summary This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 17.8), adrenal (RPKM 13.8) and 24 other tissues See more Orthologs mouse all