TNFSF15, Official Symbol TNFSF15provided by HGNC Official Full Name TNF superfamily member 15provided by HGNC Primary source HGNC:HGNC:11931 See related Ensembl:ENSG00000181634 MIM:604052; AllianceGenome:HGNC:11931 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TL1; TL1A; VEGI; TNLG1B; VEGI192A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues See more Orthologs mouse all