ADAMTS6, Official Symbol ADAMTS6provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 6provided by HGNC Primary source HGNC:HGNC:222 See related Ensembl:ENSG00000049192 MIM:605008; AllianceGenome:HGNC:222 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADAM-TS6; ADAMTS-6; ADAM-TS 6 Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016] Expression Broad expression in placenta (RPKM 1.3), gall bladder (RPKM 1.1) and 19 other tissues See more Orthologs mouse all