CHN2, Official Symbol CHN2provided by HGNC Official Full Name chimerin 2provided by HGNC Primary source HGNC:HGNC:1944 See related MIM:602857; AllianceGenome:HGNC:1944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCH; CHN2-3; ARHGAP3; RHOGAP3 Summary This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Broad expression in duodenum (RPKM 21.4), small intestine (RPKM 16.7) and 20 other tissues See more Orthologs mouse all