PKD1L2, Official Symbol PKD1L2provided by HGNC Official Full Name polycystin 1 like 2 (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:21715 See related Ensembl:ENSG00000166473 MIM:607894; AllianceGenome:HGNC:21715 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PC1L2 Summary This gene encodes a member of the polycystin protein family. This protein may function as a G-protein-coupled component or regulator of cation channel pores. The long isoform of this protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene is a polymorphic pseudogene in humans. [provided by RefSeq, May 2022] Annotation information Annotation category: suggests misassembly Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Biased expression in fat (RPKM 3.7), heart (RPKM 1.2) and 7 other tissues See more Orthologs all