FMN2, Official Symbol FMN2provided by HGNC Official Full Name formin 2provided by HGNC Primary source HGNC:HGNC:14074 See related Ensembl:ENSG00000155816 MIM:606373; AllianceGenome:HGNC:14074 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017] Expression Biased expression in brain (RPKM 8.0), adrenal (RPKM 0.9) and 3 other tissues See more Orthologs mouse all