STING1, Official Symbol STING1provided by HGNC Official Full Name stimulator of interferon response cGAMP interactor 1provided by HGNC Primary source HGNC:HGNC:27962 See related Ensembl:ENSG00000184584 MIM:612374; AllianceGenome:HGNC:27962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta Summary This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues See more Orthologs mouse all