SDR16C5, Official Symbol SDR16C5provided by HGNC Official Full Name short chain dehydrogenase/reductase family 16C member 5provided by HGNC Primary source HGNC:HGNC:30311 See related Ensembl:ENSG00000170786 MIM:608989; AllianceGenome:HGNC:30311 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDH#2; RDHE2; EPHD-2; RDH-E2; retSDR2 Summary This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in skin (RPKM 15.8), esophagus (RPKM 9.7) and 7 other tissues See more Orthologs all