STAU2, Official Symbol STAU2provided by HGNC Official Full Name staufen double-stranded RNA binding protein 2provided by HGNC Primary source HGNC:HGNC:11371 See related Ensembl:ENSG00000040341 MIM:605920; AllianceGenome:HGNC:11371 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 39K2; 39K3 Summary Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] Expression Ubiquitous expression in brain (RPKM 12.9), heart (RPKM 8.7) and 25 other tissues See more Orthologs mouse all