STEAP4, Official Symbol STEAP4provided by HGNC Official Full Name STEAP4 metalloreductaseprovided by HGNC Primary source HGNC:HGNC:21923 See related Ensembl:ENSG00000127954 MIM:611098; AllianceGenome:HGNC:21923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIARP; STAMP2; SchLAH; TNFAIP9 Summary The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] Expression Broad expression in fat (RPKM 50.0), prostate (RPKM 32.8) and 17 other tissues See more Orthologs mouse all