TES, Official Symbol TESprovided by HGNC Official Full Name testin LIM domain proteinprovided by HGNC Primary source HGNC:HGNC:14620 See related Ensembl:ENSG00000135269 MIM:606085; AllianceGenome:HGNC:14620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TESS; TESS-2 Summary Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023] Expression Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more Orthologs mouse all