CD70, Official Symbol CD70provided by HGNC Official Full Name CD70 moleculeprovided by HGNC Primary source HGNC:HGNC:11937 See related Ensembl:ENSG00000125726 MIM:602840; AllianceGenome:HGNC:11937 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all