ODF2, Official Symbol ODF2provided by HGNC Official Full Name outer dense fiber of sperm tails 2provided by HGNC Primary source HGNC:HGNC:8114 See related Ensembl:ENSG00000136811 MIM:602015; AllianceGenome:HGNC:8114 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT134; ODF84; ODF2/1; ODF2/2 Summary The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010] Expression Biased expression in testis (RPKM 95.4), lymph node (RPKM 8.1) and 9 other tissues See more Orthologs mouse all