BMP4, Official Symbol BMP4provided by HGNC Official Full Name bone morphogenetic protein 4provided by HGNC Primary source HGNC:HGNC:1071 See related Ensembl:ENSG00000125378 MIM:112262; AllianceGenome:HGNC:1071 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016] Expression Broad expression in placenta (RPKM 12.6), urinary bladder (RPKM 7.5) and 20 other tissues See more Orthologs mouse all