LOXL4, Official Symbol LOXL4provided by HGNC Official Full Name lysyl oxidase like 4provided by HGNC Primary source HGNC:HGNC:17171 See related Ensembl:ENSG00000138131 MIM:607318; AllianceGenome:HGNC:17171 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOXC Summary This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 4.0), testis (RPKM 3.7) and 22 other tissues See more Orthologs mouse all