RNF2, Official Symbol RNF2provided by HGNC Official Full Name ring finger protein 2provided by HGNC Primary source HGNC:HGNC:10061 See related Ensembl:ENSG00000121481 MIM:608985; AllianceGenome:HGNC:10061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAP1; DING; BAP-1; HIPI3; RING2; LUSYAM; RING1B Summary Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 7.8), placenta (RPKM 6.0) and 25 other tissues See more Orthologs mouse all