IL12RB1, Official Symbol IL12RB1provided by HGNC Official Full Name interleukin 12 receptor subunit beta 1provided by HGNC Primary source HGNC:HGNC:5971 See related Ensembl:ENSG00000096996 MIM:601604; AllianceGenome:HGNC:5971 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD212; IMD30; IL12RB; IL-12R-BETA1 Summary The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Biased expression in lymph node (RPKM 5.0), spleen (RPKM 4.1) and 13 other tissues See more Orthologs mouse all