APC, Official Symbol APCprovided by HGNC Official Full Name APC regulator of WNT signaling pathwayprovided by HGNC Primary source HGNC:HGNC:583 See related Ensembl:ENSG00000134982 MIM:611731; AllianceGenome:HGNC:583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46 Summary This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022] Annotation information Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019] Expression Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues See more Orthologs mouse all