TGM1, Official Symbol TGM1provided by HGNC Official Full Name transglutaminase 1provided by HGNC Primary source HGNC:HGNC:11777 See related Ensembl:ENSG00000092295 MIM:190195; AllianceGenome:HGNC:11777 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LI; KTG; LI1; TGK; ICR2; ARCI1; TGASE Summary The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008] Expression Restricted expression toward esophagus (RPKM 291.1) See more Orthologs mouse all