NRAS, Official Symbol NRASprovided by HGNC Official Full Name NRAS proto-oncogene, GTPaseprovided by HGNC Primary source HGNC:HGNC:7989 See related Ensembl:ENSG00000213281 MIM:164790; AllianceGenome:HGNC:7989 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NS6; CMNS; KRAS; NCMS; ALPS4; N-ras; NRAS1 Summary This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] Expression Ubiquitous expression in bone marrow (RPKM 23.0), colon (RPKM 17.3) and 25 other tissues See more Orthologs mouse all