NFE4, Official Symbol NFE4provided by HGNC Official Full Name nuclear factor, erythroid 4provided by HGNC Primary source HGNC:HGNC:29902 See related Ensembl:ENSG00000230257 MIM:612133; AllianceGenome:HGNC:29902 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NF-E4 Summary The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 1.2), appendix (RPKM 0.3) and 3 other tissues See more Orthologs all