RASGRF2, Official Symbol RASGRF2provided by HGNC Official Full Name Ras protein specific guanine nucleotide releasing factor 2provided by HGNC Primary source HGNC:HGNC:9876 See related Ensembl:ENSG00000113319 MIM:606614; AllianceGenome:HGNC:9876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRF2; RAS-GRF2 Summary RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011] Expression Broad expression in brain (RPKM 9.6), ovary (RPKM 7.2) and 18 other tissues See more Orthologs mouse all