USP21, Official Symbol USP21provided by HGNC Official Full Name ubiquitin specific peptidase 21provided by HGNC Primary source HGNC:HGNC:12620 See related Ensembl:ENSG00000143258 MIM:604729; AllianceGenome:HGNC:12620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP16; USP23 Summary This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in ovary (RPKM 11.4), testis (RPKM 9.2) and 25 other tissues See more Orthologs mouse all