VAV3, Official Symbol VAV3provided by HGNC Official Full Name vav guanine nucleotide exchange factor 3provided by HGNC Primary source HGNC:HGNC:12659 See related Ensembl:ENSG00000134215 MIM:605541; AllianceGenome:HGNC:12659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 10.0), skin (RPKM 8.3) and 17 other tissues See more Orthologs mouse all