FBXW10, Official Symbol FBXW10provided by HGNC Official Full Name F-box and WD repeat domain containing 10provided by HGNC Primary source HGNC:HGNC:1211 See related Ensembl:ENSG00000171931 MIM:611679; AllianceGenome:HGNC:1211 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HREP; Fbw10; SM25H2; SM2SH2 Summary Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] Expression Biased expression in testis (RPKM 6.8) and esophagus (RPKM 0.4) See more Orthologs mouse all