NPL, Official Symbol NPLprovided by HGNC Official Full Name N-acetylneuraminate pyruvate lyaseprovided by HGNC Primary source HGNC:HGNC:16781 See related Ensembl:ENSG00000135838 MIM:611412; AllianceGenome:HGNC:16781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAL; C112; NPL1; C1orf13 Summary This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Broad expression in placenta (RPKM 18.1), kidney (RPKM 16.5) and 20 other tissues See more Orthologs mouse all