RNF20, Official Symbol RNF20provided by HGNC Official Full Name ring finger protein 20provided by HGNC Primary source HGNC:HGNC:10062 See related Ensembl:ENSG00000155827 MIM:607699; AllianceGenome:HGNC:10062 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRE1; BRE1A; hBRE1 Summary The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in testis (RPKM 16.7), brain (RPKM 13.7) and 25 other tissues See more Orthologs mouse all