RCHY1, Official Symbol RCHY1provided by HGNC Official Full Name ring finger and CHY zinc finger domain containing 1provided by HGNC Primary source HGNC:HGNC:17479 See related Ensembl:ENSG00000163743 MIM:607680; AllianceGenome:HGNC:17479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996 Summary The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in thyroid (RPKM 7.9), bone marrow (RPKM 6.3) and 25 other tissues See more Orthologs mouse all