PGR, Official Symbol PGRprovided by HGNC Official Full Name progesterone receptorprovided by HGNC Primary source HGNC:HGNC:8910 See related Ensembl:ENSG00000082175 MIM:607311; AllianceGenome:HGNC:8910 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PR; NR3C3 Summary This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015] Expression Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5) See more Orthologs mouse all