LHX3, Official Symbol LHX3provided by HGNC Official Full Name LIM homeobox 3provided by HGNC Primary source HGNC:HGNC:6595 See related Ensembl:ENSG00000107187 MIM:600577; AllianceGenome:HGNC:6595 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIM3; CPHD3; M2-LHX3 Summary This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all