GSTA1, Official Symbol GSTA1provided by HGNC Official Full Name glutathione S-transferase alpha 1provided by HGNC Primary source HGNC:HGNC:4626 See related Ensembl:ENSG00000243955 MIM:138359; AllianceGenome:HGNC:4626 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GST2; GTH1; GSTA1-1; GST-epsilon Summary This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 342.4), kidney (RPKM 288.3) and 6 other tissues See more Orthologs all