CREM, Official Symbol CREMprovided by HGNC Official Full Name cAMP responsive element modulatorprovided by HGNC Primary source HGNC:HGNC:2352 See related Ensembl:ENSG00000095794 MIM:123812; AllianceGenome:HGNC:2352 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ICER; CREM-2; hCREM-2 Summary This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues See more Orthologs mouse all