HPN, Official Symbol HPNprovided by HGNC Official Full Name hepsinprovided by HGNC Primary source HGNC:HGNC:5155 See related Ensembl:ENSG00000105707 MIM:142440; AllianceGenome:HGNC:5155 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMPRSS1 Summary This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Biased expression in liver (RPKM 53.7), kidney (RPKM 49.5) and 5 other tissues See more Orthologs mouse all