SEC61A1, Official Symbol SEC61A1provided by HGNC Official Full Name SEC61 translocon subunit alpha 1provided by HGNC Primary source HGNC:HGNC:18276 See related Ensembl:ENSG00000058262 MIM:609213; AllianceGenome:HGNC:18276 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNFJ4; SEC61; ADTKD5; HSEC61; SEC61A Summary The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 81.0), placenta (RPKM 70.7) and 25 other tissues See more Orthologs mouse all