PPM1D, Official Symbol PPM1Dprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Dprovided by HGNC Primary source HGNC:HGNC:9277 See related Ensembl:ENSG00000170836 MIM:605100; AllianceGenome:HGNC:9277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JDVS; WIP1; IDDGIP; PP2C-DELTA Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 7.0), ovary (RPKM 5.5) and 25 other tissues See more Orthologs mouse all