COA8, Official Symbol COA8provided by HGNC Official Full Name cytochrome c oxidase assembly factor 8provided by HGNC Primary source HGNC:HGNC:20492 See related Ensembl:ENSG00000256053 MIM:616003; AllianceGenome:HGNC:20492 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APOP; APOP1; APOPT1; MC4DN17; C14orf153 Summary This gene encodes a protein that localizes to the mitochondria, where it stimulates the release of cytochrome c, thereby promoting programmed cell death. Mutations in this gene have been found in individuals with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Expression Ubiquitous expression in testis (RPKM 10.4), fat (RPKM 5.7) and 25 other tissues See more Orthologs mouse all