ALOX5AP, Official Symbol ALOX5APprovided by HGNC Official Full Name arachidonate 5-lipoxygenase activating proteinprovided by HGNC Primary source HGNC:HGNC:436 See related Ensembl:ENSG00000132965 MIM:603700; AllianceGenome:HGNC:436 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLAP Summary This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in bone marrow (RPKM 94.5), lung (RPKM 39.9) and 14 other tissues See more Orthologs mouse all