THOP1, Official Symbol THOP1provided by HGNC Official Full Name thimet oligopeptidase 1provided by HGNC Primary source HGNC:HGNC:11793 See related Ensembl:ENSG00000172009 MIM:601117; AllianceGenome:HGNC:11793 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOP; MP78; EP24.15; MEPD_HUMAN Summary The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015] Expression Broad expression in testis (RPKM 14.1), brain (RPKM 6.4) and 24 other tissues See more Orthologs mouse all