ASH2L, Official Symbol ASH2Lprovided by HGNC Official Full Name ASH2 like, histone lysine methyltransferase complex subunitprovided by HGNC Primary source HGNC:HGNC:744 See related Ensembl:ENSG00000129691 MIM:604782; AllianceGenome:HGNC:744 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASH2; Bre2; ASH2L1; ASH2L2 Summary Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation; positive regulation of cell population proliferation; and response to estrogen. Acts upstream of or within cellular response to DNA damage stimulus. Located in nucleus. Part of MLL3/4 complex and Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 20.9), fat (RPKM 13.3) and 25 other tissues See more Orthologs mouse all