MDFI, Official Symbol MDFIprovided by HGNC Official Full Name MyoD family inhibitorprovided by HGNC Primary source HGNC:HGNC:6967 See related Ensembl:ENSG00000112559 MIM:604971; AllianceGenome:HGNC:6967 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as I-MF; I-mfa Summary This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 11.0), placenta (RPKM 3.0) and 12 other tissues See more Orthologs mouse all