CRTC2, Official Symbol CRTC2provided by HGNC Official Full Name CREB regulated transcription coactivator 2provided by HGNC Primary source HGNC:HGNC:27301 See related Ensembl:ENSG00000160741 MIM:608972; AllianceGenome:HGNC:27301 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TORC2; TORC-2 Summary This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in spleen (RPKM 17.9), bone marrow (RPKM 17.3) and 25 other tissues See more Orthologs mouse all