PEPD, Official Symbol PEPDprovided by HGNC Official Full Name peptidase Dprovided by HGNC Primary source HGNC:HGNC:8840 See related Ensembl:ENSG00000124299 MIM:613230; AllianceGenome:HGNC:8840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PROLIDASE Summary This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Expression Broad expression in kidney (RPKM 221.6), small intestine (RPKM 95.0) and 19 other tissues See more Orthologs mouse all