PFKFB1, Official Symbol PFKFB1provided by HGNC Official Full Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1provided by HGNC Primary source HGNC:HGNC:8872 See related Ensembl:ENSG00000158571 MIM:311790; AllianceGenome:HGNC:8872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as F6PK; HL2K; PFRX Summary This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] Expression Biased expression in fat (RPKM 14.1) and liver (RPKM 5.1) See more Orthologs mouse all