GAB3, Official Symbol GAB3provided by HGNC Official Full Name GRB2 associated binding protein 3provided by HGNC Primary source HGNC:HGNC:17515 See related Ensembl:ENSG00000160219 MIM:300482; AllianceGenome:HGNC:17515 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Broad expression in spleen (RPKM 7.6), bone marrow (RPKM 4.4) and 22 other tissues See more Orthologs mouse all