HSD17B3, Official Symbol HSD17B3provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 3provided by HGNC Primary source HGNC:HGNC:5212 See related Ensembl:ENSG00000130948 MIM:605573; AllianceGenome:HGNC:5212 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDH17B3; SDR12C2 Summary This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 7.7), small intestine (RPKM 0.7) and 4 other tissues See more Orthologs mouse all