FHL2, Official Symbol FHL2provided by HGNC Official Full Name four and a half LIM domains 2provided by HGNC Primary source HGNC:HGNC:3703 See related Ensembl:ENSG00000115641 MIM:602633; AllianceGenome:HGNC:3703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRAL; AAG11; FHL-2; SLIM3; SLIM-3 Summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016] Expression Biased expression in heart (RPKM 149.2), ovary (RPKM 139.8) and 13 other tissues See more Orthologs mouse all