RASAL3, Official Symbol RASAL3provided by HGNC Official Full Name RAS protein activator like 3provided by HGNC Primary source HGNC:HGNC:26129 See related Ensembl:ENSG00000105122 MIM:616561; AllianceGenome:HGNC:26129 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017] Expression Broad expression in lymph node (RPKM 18.0), spleen (RPKM 15.7) and 14 other tissues See more Orthologs mouse all