RASGRP1, Official Symbol RASGRP1provided by HGNC Official Full Name RAS guanyl releasing protein 1provided by HGNC Primary source HGNC:HGNC:9878 See related Ensembl:ENSG00000172575 MIM:603962; AllianceGenome:HGNC:9878 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD64; RASGRP; CALDAG-GEFI; CALDAG-GEFII Summary This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 12.0), brain (RPKM 10.5) and 15 other tissues See more Orthologs mouse all