ALDH1L1, Official Symbol ALDH1L1provided by HGNC Official Full Name aldehyde dehydrogenase 1 family member L1provided by HGNC Primary source HGNC:HGNC:3978 See related Ensembl:ENSG00000144908 MIM:600249; AllianceGenome:HGNC:3978 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FDH; FTHFD; 10-fTHF; 10-FTHFDH Summary The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Expression Biased expression in liver (RPKM 99.3), kidney (RPKM 65.2) and 8 other tissues See more Orthologs mouse all