SST, Official Symbol SSTprovided by HGNC Official Full Name somatostatinprovided by HGNC Primary source HGNC:HGNC:11329 See related Ensembl:ENSG00000157005 MIM:182450; AllianceGenome:HGNC:11329 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMST; SST1 Summary The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008] Expression Biased expression in stomach (RPKM 141.6), duodenum (RPKM 136.3) and 5 other tissues See more Orthologs mouse all