AGO1, Official Symbol AGO1provided by HGNC Official Full Name argonaute RISC component 1provided by HGNC Primary source HGNC:HGNC:3262 See related Ensembl:ENSG00000092847 MIM:606228; AllianceGenome:HGNC:3262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Q99; EIF2C; hAgo1; EIF2C1; GERP95; NEDLBAS Summary This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in skin (RPKM 4.5), brain (RPKM 3.9) and 25 other tissues See more Orthologs mouse all