GPLD1, Official Symbol GPLD1provided by HGNC Official Full Name glycosylphosphatidylinositol specific phospholipase D1provided by HGNC Primary source HGNC:HGNC:4459 See related Ensembl:ENSG00000112293 MIM:602515; AllianceGenome:HGNC:4459 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1 Summary Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 12.6), skin (RPKM 4.0) and 8 other tissues See more Orthologs mouse all