RELN, Official Symbol RELNprovided by HGNC Official Full Name reelinprovided by HGNC Primary source HGNC:HGNC:9957 See related Ensembl:ENSG00000189056 MIM:600514; AllianceGenome:HGNC:9957 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RL; ETL7; LIS2; PRO1598 Summary This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 8.4), adrenal (RPKM 1.9) and 11 other tissues See more Orthologs mouse all