GZMH, Official Symbol GZMHprovided by HGNC Official Full Name granzyme Hprovided by HGNC Primary source HGNC:HGNC:4710 See related Ensembl:ENSG00000100450 MIM:116831; AllianceGenome:HGNC:4710 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2 Summary This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015] Expression Broad expression in spleen (RPKM 9.5), bone marrow (RPKM 8.3) and 21 other tissues See more Orthologs mouse all