SEC62, Official Symbol SEC62provided by HGNC Official Full Name SEC62 homolog, preprotein translocation factorprovided by HGNC Primary source HGNC:HGNC:11846 See related Ensembl:ENSG00000008952 MIM:602173; AllianceGenome:HGNC:11846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTP1; TP-1; Dtrp1; TLOC1 Summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 46.4), brain (RPKM 36.2) and 25 other tissues See more Orthologs mouse all