HSD17B8, Official Symbol HSD17B8provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 8provided by HGNC Primary source HGNC:HGNC:3554 See related Ensembl:ENSG00000204228 MIM:601417; AllianceGenome:HGNC:3554 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9 Summary In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 17.4), kidney (RPKM 16.9) and 25 other tissues See more Orthologs mouse all