MAF1, Official Symbol MAF1provided by HGNC Official Full Name MAF1 homolog, negative regulator of RNA polymerase IIIprovided by HGNC Primary source HGNC:HGNC:24966 See related Ensembl:ENSG00000179632 MIM:610210; AllianceGenome:HGNC:24966 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 39.1), ovary (RPKM 34.7) and 25 other tissues See more Orthologs mouse all