AOC2, Official Symbol AOC2provided by HGNC Official Full Name amine oxidase copper containing 2provided by HGNC Primary source HGNC:HGNC:549 See related Ensembl:ENSG00000131480 MIM:602268; AllianceGenome:HGNC:549 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAO; DAO2; SSAO Summary Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 4.0), testis (RPKM 2.5) and 14 other tissues See more Orthologs mouse all