HES6, Official Symbol HES6provided by HGNC Official Full Name hes family bHLH transcription factor 6provided by HGNC Primary source HGNC:HGNC:18254 See related Ensembl:ENSG00000144485 MIM:610331; AllianceGenome:HGNC:18254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HES-6; bHLHb41; bHLHc23; C-HAIRY1 Summary This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008] Expression Biased expression in brain (RPKM 23.5), colon (RPKM 8.2) and 12 other tissues See more Orthologs mouse all