CNR1, Official Symbol CNR1provided by HGNC Official Full Name cannabinoid receptor 1provided by HGNC Primary source HGNC:HGNC:2159 See related Ensembl:ENSG00000118432 MIM:114610; AllianceGenome:HGNC:2159 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5 Summary This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009] Expression Biased expression in brain (RPKM 6.2), fat (RPKM 2.7) and 12 other tissues See more Orthologs mouse all