PRRX1, Official Symbol PRRX1provided by HGNC Official Full Name paired related homeobox 1provided by HGNC Primary source HGNC:HGNC:9142 See related Ensembl:ENSG00000116132 MIM:167420; AllianceGenome:HGNC:9142 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PMX1; PRX1; AGOTC; PHOX1; PRX-1 Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 34.6), fat (RPKM 27.9) and 17 other tissues See more Orthologs mouse all