ITGA2B, Official Symbol ITGA2Bprovided by HGNC Official Full Name integrin subunit alpha 2bprovided by HGNC Primary source HGNC:HGNC:6138 See related Ensembl:ENSG00000005961 MIM:607759; AllianceGenome:HGNC:6138 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GT; GT1; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93 Summary This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016] Expression Biased expression in bone marrow (RPKM 6.2), testis (RPKM 1.4) and 8 other tissues See more Orthologs mouse all