KRT8, Official Symbol KRT8provided by HGNC Official Full Name keratin 8provided by HGNC Primary source HGNC:HGNC:6446 See related Ensembl:ENSG00000170421 MIM:148060; AllianceGenome:HGNC:6446 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as K8; KO; CK8; CK-8; CYK8; K2C8; CARD2 Summary This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] Expression Biased expression in colon (RPKM 581.2), small intestine (RPKM 486.1) and 13 other tissues See more Orthologs mouse all