PPM1F, Official Symbol PPM1Fprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Fprovided by HGNC Primary source HGNC:HGNC:19388 See related Ensembl:ENSG00000100034 MIM:619309; AllianceGenome:HGNC:19388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 16.9), spleen (RPKM 14.5) and 24 other tissues See more Orthologs mouse all