RFX1, Official Symbol RFX1provided by HGNC Official Full Name regulatory factor X1provided by HGNC Primary source HGNC:HGNC:9982 See related Ensembl:ENSG00000132005 MIM:600006; AllianceGenome:HGNC:9982 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFC; RFX Summary This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016] Expression Broad expression in testis (RPKM 5.4), spleen (RPKM 2.7) and 25 other tissues See more Orthologs mouse all