TRIOBP, Official Symbol TRIOBPprovided by HGNC Official Full Name TRIO and F-actin binding proteinprovided by HGNC Primary source HGNC:HGNC:17009 See related Ensembl:ENSG00000100106 MIM:609761; AllianceGenome:HGNC:17009 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TARA; TAP68; DFNB28; dJ37E16.4; HRIHFB2122 Summary This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in spleen (RPKM 8.0), placenta (RPKM 7.0) and 25 other tissues See more Orthologs mouse all