PPARD, Official Symbol PPARDprovided by HGNC Official Full Name peroxisome proliferator activated receptor deltaprovided by HGNC Primary source HGNC:HGNC:9235 See related Ensembl:ENSG00000112033 MIM:600409; AllianceGenome:HGNC:9235 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB Summary This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in placenta (RPKM 13.1), thyroid (RPKM 10.8) and 25 other tissues See more Orthologs mouse all