SPTLC2, Official Symbol SPTLC2provided by HGNC Official Full Name serine palmitoyltransferase long chain base subunit 2provided by HGNC Primary source HGNC:HGNC:11278 See related Ensembl:ENSG00000100596 MIM:605713; AllianceGenome:HGNC:11278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a Summary This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in esophagus (RPKM 11.7), colon (RPKM 11.4) and 25 other tissues See more Orthologs mouse all