MAP4K4, Official Symbol MAP4K4provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC Primary source HGNC:HGNC:6866 See related Ensembl:ENSG00000071054 MIM:604666; AllianceGenome:HGNC:6866 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HGK; NIK; MEKKK4; FLH21957; HEL-S-31 Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more Orthologs mouse all