KLF12, Official Symbol KLF12provided by HGNC Official Full Name KLF transcription factor 12provided by HGNC Primary source HGNC:HGNC:6346 See related Ensembl:ENSG00000118922 MIM:607531; AllianceGenome:HGNC:6346 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AP2REP; AP-2rep; HSPC122 Summary Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 6.4), spleen (RPKM 4.4) and 24 other tissues See more Orthologs mouse all