TMX2, Official Symbol TMX2provided by HGNC Official Full Name thioredoxin related transmembrane protein 2provided by HGNC Primary source HGNC:HGNC:30739 See related Ensembl:ENSG00000213593 MIM:616715; AllianceGenome:HGNC:30739 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIG26; CGI-31; PDIA12; NEDMCMS; TXNDC14 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in brain (RPKM 42.0), thyroid (RPKM 36.4) and 25 other tissues See more Orthologs mouse all