PPP1R8, Official Symbol PPP1R8provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 8provided by HGNC Primary source HGNC:HGNC:9296 See related Ensembl:ENSG00000117751 MIM:602636; AllianceGenome:HGNC:9296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARD1; ARD-1; NIPP1; NIPP-1; PRO2047 Summary This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 13.4), lymph node (RPKM 13.2) and 25 other tissues See more Orthologs mouse all