BCL3, Official Symbol BCL3provided by HGNC Official Full Name BCL3 transcription coactivatorprovided by HGNC Primary source HGNC:HGNC:998 See related Ensembl:ENSG00000069399 MIM:109560; AllianceGenome:HGNC:998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCL4; D19S37 Summary This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 8.4), small intestine (RPKM 7.7) and 24 other tissues See more Orthologs mouse all