PREP, Official Symbol PREPprovided by HGNC Official Full Name prolyl endopeptidaseprovided by HGNC Primary source HGNC:HGNC:9358 See related Ensembl:ENSG00000085377 MIM:600400; AllianceGenome:HGNC:9358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PE; PEP Summary The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008] Annotation information Note: The official gene symbol PREP (prolyl endopeptidase) on GeneID: 5550 can be confused with the alias for presequence protease (PREP) on GeneID: 10531 whose official symbol is PITRM1 (pitrilysin metallopeptidase 1). [20 Jun 2018] Expression Ubiquitous expression in colon (RPKM 8.2), testis (RPKM 5.6) and 25 other tissues See more Orthologs mouse all