PRDX4, Official Symbol PRDX4provided by HGNC Official Full Name peroxiredoxin 4provided by HGNC Primary source HGNC:HGNC:17169 See related Ensembl:ENSG00000123131 MIM:300927; AllianceGenome:HGNC:17169 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRX-4; AOE372; AOE37-2; HEL-S-97n Summary The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in pancreas (RPKM 49.0), liver (RPKM 22.7) and 25 other tissues See more Orthologs mouse all