COP1, Official Symbol COP1provided by HGNC Official Full Name COP1 E3 ubiquitin ligaseprovided by HGNC Primary source HGNC:HGNC:17440 See related Ensembl:ENSG00000143207 MIM:608067; AllianceGenome:HGNC:17440 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAP78; RFWD2; CFAP78; RNF200 Summary Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 5.8), colon (RPKM 4.2) and 25 other tissues See more Orthologs mouse all