SIPA1, Official Symbol SIPA1provided by HGNC Official Full Name signal-induced proliferation-associated 1provided by HGNC Primary source HGNC:HGNC:10885 See related Ensembl:ENSG00000213445 MIM:602180; AllianceGenome:HGNC:10885 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPA1 Summary The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues See more Orthologs mouse all