FGA, Official Symbol FGAprovided by HGNC Official Full Name fibrinogen alpha chainprovided by HGNC Primary source HGNC:HGNC:3661 See related Ensembl:ENSG00000171560 MIM:134820; AllianceGenome:HGNC:3661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Fib2 Summary This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016] Expression Restricted expression toward liver (RPKM 2863.0) See more Orthologs mouse all