EIF2B5, Official Symbol EIF2B5provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit epsilonprovided by HGNC Primary source HGNC:HGNC:3261 See related Ensembl:ENSG00000145191 MIM:603945; AllianceGenome:HGNC:3261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLE; CACH; LVWM; VWM5; EIF-2B; EIF2Bepsilon Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] Expression Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 11.5) and 25 other tissues See more Orthologs mouse all