KLKB1, Official Symbol KLKB1provided by HGNC Official Full Name kallikrein B1provided by HGNC Primary source HGNC:HGNC:6371 See related Ensembl:ENSG00000164344 MIM:229000; AllianceGenome:HGNC:6371 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKK; PPK; KLK3; PKKD Summary This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 44.5) and kidney (RPKM 1.2) See more Orthologs mouse all