RASSF8, Official Symbol RASSF8provided by HGNC Official Full Name Ras association domain family member 8provided by HGNC Primary source HGNC:HGNC:13232 See related Ensembl:ENSG00000123094 MIM:608231; AllianceGenome:HGNC:13232 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOJ1; C12orf2 Summary This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] Expression Broad expression in testis (RPKM 13.9), endometrium (RPKM 13.0) and 23 other tissues See more Orthologs mouse all