HES1, Official Symbol HES1provided by HGNC Official Full Name hes family bHLH transcription factor 1provided by HGNC Primary source HGNC:HGNC:5192 See related Ensembl:ENSG00000114315 MIM:139605; AllianceGenome:HGNC:5192 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHL; HRY; HES-1; bHLHb39 Summary This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 46.7), thyroid (RPKM 44.9) and 24 other tissues See more Orthologs mouse all