MRC1, Official Symbol MRC1provided by HGNC Official Full Name mannose receptor C-type 1provided by HGNC Primary source HGNC:HGNC:7228 See related Ensembl:ENSG00000260314 MIM:153618; AllianceGenome:HGNC:7228 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1 Summary The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015] Annotation information Note: In the NCBI Build 37.2 reference assembly, MRC1 and MRC1L1 are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. Two of the clones on which MRC1L1 was based (AL928580, BX255924) will be removed from the reference assembly and only MRC1 will be present in the assembly. [13 Feb 2013] Expression Broad expression in lung (RPKM 50.7), spleen (RPKM 28.0) and 19 other tissues See more Orthologs mouse all