HINT1, Official Symbol HINT1provided by HGNC Official Full Name histidine triad nucleotide binding protein 1provided by HGNC Primary source HGNC:HGNC:4912 See related Ensembl:ENSG00000169567 MIM:601314; AllianceGenome:HGNC:4912 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HINT; NMAN; PKCI-1; PRKCNH1 Summary This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in colon (RPKM 85.2), liver (RPKM 83.5) and 25 other tissues See more Orthologs mouse all