CREB3L3, Official Symbol CREB3L3provided by HGNC Official Full Name cAMP responsive element binding protein 3 like 3provided by HGNC Primary source HGNC:HGNC:18855 See related Ensembl:ENSG00000060566 MIM:611998; AllianceGenome:HGNC:18855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CREBH; HYTG2; CREB-H; HYST1481 Summary This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] Expression Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue See more Orthologs mouse all