ARHGAP35, Official Symbol ARHGAP35provided by HGNC Official Full Name Rho GTPase activating protein 35provided by HGNC Primary source HGNC:HGNC:4591 See related Ensembl:ENSG00000160007 MIM:605277; AllianceGenome:HGNC:4591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP Summary The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues See more Orthologs mouse all