SP1, Official Symbol SP1provided by HGNC Official Full Name Sp1 transcription factorprovided by HGNC Primary source HGNC:HGNC:11205 See related Ensembl:ENSG00000185591 MIM:189906; AllianceGenome:HGNC:11205 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] Expression Ubiquitous expression in skin (RPKM 18.2), endometrium (RPKM 16.6) and 25 other tissues See more Orthologs mouse all