HOXD10, Official Symbol HOXD10provided by HGNC Official Full Name homeobox D10provided by HGNC Primary source HGNC:HGNC:5133 See related Ensembl:ENSG00000128710 MIM:142984; AllianceGenome:HGNC:5133 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX4; HOX4D; HOX4E; Hox-4.4 Summary This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 21.4), kidney (RPKM 9.2) and 4 other tissues See more Orthologs mouse all