DLG1, Official Symbol DLG1provided by HGNC Official Full Name discs large MAGUK scaffold protein 1provided by HGNC Primary source HGNC:HGNC:2900 See related Ensembl:ENSG00000075711 MIM:601014; AllianceGenome:HGNC:2900 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hdlg; DLGH1; SAP97; SAP-97 Summary This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018] Expression Ubiquitous expression in thyroid (RPKM 13.8), brain (RPKM 11.7) and 25 other tissues See more Orthologs mouse all