GNRH1, Official Symbol GNRH1provided by HGNC Official Full Name gonadotropin releasing hormone 1provided by HGNC Primary source HGNC:HGNC:4419 See related Ensembl:ENSG00000147437 MIM:152760; AllianceGenome:HGNC:4419 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRH; GNRH; LHRH; LNRH Summary This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in skin (RPKM 3.5), lymph node (RPKM 1.1) and 23 other tissues See more Orthologs mouse all