ABCB11, Official Symbol ABCB11provided by HGNC Official Full Name ATP binding cassette subfamily B member 11provided by HGNC Primary source HGNC:HGNC:42 See related Ensembl:ENSG00000073734 MIM:603201; AllianceGenome:HGNC:42 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2 Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 10.4), testis (RPKM 2.0) and 1 other tissue See more Orthologs mouse all