UBE2R2, Official Symbol UBE2R2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 R2provided by HGNC Primary source HGNC:HGNC:19907 See related Ensembl:ENSG00000107341 MIM:612506; AllianceGenome:HGNC:19907 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC3B; CDC34B; E2-CDC34B Summary Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 25.6), endometrium (RPKM 16.9) and 25 other tissues See more Orthologs mouse all