IL17RB, Official Symbol IL17RBprovided by HGNC Official Full Name interleukin 17 receptor Bprovided by HGNC Primary source HGNC:HGNC:18015 See related Ensembl:ENSG00000056736 MIM:605458; AllianceGenome:HGNC:18015 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRL4; EVI27; IL17BR; IL17RH1 Summary The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues See more Orthologs mouse all