PRKD3, Official Symbol PRKD3provided by HGNC Official Full Name protein kinase D3provided by HGNC Primary source HGNC:HGNC:9408 See related Ensembl:ENSG00000115825 MIM:607077; AllianceGenome:HGNC:9408 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU Summary This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in lymph node (RPKM 16.0), testis (RPKM 14.3) and 25 other tissues See more Orthologs mouse all