APH1B, Official Symbol APH1Bprovided by HGNC Official Full Name aph-1 homolog B, gamma-secretase subunitprovided by HGNC Primary source HGNC:HGNC:24080 See related Ensembl:ENSG00000138613 MIM:607630; AllianceGenome:HGNC:24080 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSFL; APH-1B; PRO1328; TAAV688; aph-1beta Summary This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011] Expression Broad expression in testis (RPKM 23.1), thyroid (RPKM 13.1) and 22 other tissues See more Orthologs mouse all