PFKFB3, Official Symbol PFKFB3provided by HGNC Official Full Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by HGNC Primary source HGNC:HGNC:8874 See related Ensembl:ENSG00000170525 MIM:605319; AllianceGenome:HGNC:8874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFK2; IPFK2; iPFK-2 Summary The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] Expression Biased expression in fat (RPKM 188.2), bone marrow (RPKM 67.0) and 9 other tissues See more Orthologs mouse all