PFKFB2, Official Symbol PFKFB2provided by HGNC Official Full Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by HGNC Primary source HGNC:HGNC:8873 See related Ensembl:ENSG00000123836 MIM:171835; AllianceGenome:HGNC:8873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFK-2/FBPase-2 Summary The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 25.6), duodenum (RPKM 11.7) and 19 other tissues See more Orthologs mouse all