BTC, Official Symbol BTCprovided by HGNC Official Full Name betacellulinprovided by HGNC Primary source HGNC:HGNC:1121 See related Ensembl:ENSG00000174808 MIM:600345; AllianceGenome:HGNC:1121 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015] Expression Broad expression in skin (RPKM 3.9), esophagus (RPKM 3.5) and 18 other tissues See more Orthologs mouse all