PDE4C, Official Symbol PDE4Cprovided by HGNC Official Full Name phosphodiesterase 4Cprovided by HGNC Primary source HGNC:HGNC:8782 See related Ensembl:ENSG00000105650 MIM:600128; AllianceGenome:HGNC:8782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPDE1; PDE21 Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Expression Broad expression in placenta (RPKM 1.5), endometrium (RPKM 1.5) and 20 other tissues See more Orthologs mouse all