PPP2R3C, Official Symbol PPP2R3Cprovided by HGNC Official Full Name protein phosphatase 2 regulatory subunit B''gammaprovided by HGNC Primary source HGNC:HGNC:17485 See related Ensembl:ENSG00000092020 MIM:615902; AllianceGenome:HGNC:17485 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G4-1; G5pr; GDRM; MEGD; SPGF36; C14orf10 Summary This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Expression Broad expression in testis (RPKM 18.2), bone marrow (RPKM 7.6) and 24 other tissues See more Orthologs all