PON3, Official Symbol PON3provided by HGNC Official Full Name paraoxonase 3provided by HGNC Primary source HGNC:HGNC:9206 See related Ensembl:ENSG00000105852 MIM:602720; AllianceGenome:HGNC:9206 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 130.3) and ovary (RPKM 7.4) See more Orthologs mouse all