TLR1, Official Symbol TLR1provided by HGNC Official Full Name toll like receptor 1provided by HGNC Primary source HGNC:HGNC:11847 See related Ensembl:ENSG00000174125 MIM:601194; AllianceGenome:HGNC:11847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIL; CD281; rsc786; TIL. LPRS5 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 7.0), spleen (RPKM 4.9) and 24 other tissues See more Orthologs mouse all