KPNA4, Official Symbol KPNA4provided by HGNC Official Full Name karyopherin subunit alpha 4provided by HGNC Primary source HGNC:HGNC:6397 See related Ensembl:ENSG00000186432 MIM:602970; AllianceGenome:HGNC:6397 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as QIP1; SRP3; IPOA3 Summary The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 11.7), esophagus (RPKM 9.8) and 25 other tissues See more Orthologs mouse all