PLCB4, Official Symbol PLCB4provided by HGNC Official Full Name phospholipase C beta 4provided by HGNC Primary source HGNC:HGNC:9059 See related Ensembl:ENSG00000101333 MIM:600810; AllianceGenome:HGNC:9059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARCND2; PI-PLC; ARCND2A; ARCND2B Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010] Expression Broad expression in thyroid (RPKM 7.9), salivary gland (RPKM 5.4) and 19 other tissues See more Orthologs mouse all