MYZAP, Official Symbol MYZAPprovided by HGNC Official Full Name myocardial zonula adherens proteinprovided by HGNC Primary source HGNC:HGNC:43444 See related Ensembl:ENSG00000263155 MIM:614071; AllianceGenome:HGNC:43444 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gup; GCOM1; MYOZAP Summary This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014] Expression Biased expression in heart (RPKM 228.1), fat (RPKM 55.5) and 5 other tissues See more Orthologs mouse all