ADRA1A, Official Symbol ADRA1Aprovided by HGNC Official Full Name adrenoceptor alpha 1Aprovided by HGNC Primary source HGNC:HGNC:277 See related Ensembl:ENSG00000120907 MIM:104221; AllianceGenome:HGNC:277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADRA1C; ADRA1L1; ALPHA1AAR Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues See more Orthologs mouse all