HERC3, Official Symbol HERC3provided by HGNC Official Full Name HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by HGNC Primary source HGNC:HGNC:4876 See related Ensembl:ENSG00000138641 MIM:605200; AllianceGenome:HGNC:4876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in prostate (RPKM 6.4), thyroid (RPKM 5.6) and 25 other tissues See more Orthologs mouse all