C8A, Official Symbol C8Aprovided by HGNC Official Full Name complement C8 alpha chainprovided by HGNC Primary source HGNC:HGNC:1352 See related Ensembl:ENSG00000157131 MIM:120950; AllianceGenome:HGNC:1352 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008] Expression Restricted expression toward liver (RPKM 74.5) See more Orthologs mouse all