NTRK3, Official Symbol NTRK3provided by HGNC Official Full Name neurotrophic receptor tyrosine kinase 3provided by HGNC Primary source HGNC:HGNC:8033 See related Ensembl:ENSG00000140538 MIM:191316; AllianceGenome:HGNC:8033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRKC; GP145-TrkC; gp145(trkC) Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] Expression Biased expression in brain (RPKM 2.8), fat (RPKM 1.2) and 13 other tissues See more Orthologs mouse all