NKX2-8, Official Symbol NKX2-8provided by HGNC Official Full Name NK2 homeobox 8provided by HGNC Primary source HGNC:HGNC:16364 See related Ensembl:ENSG00000136327 MIM:603245; AllianceGenome:HGNC:16364 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKX2H; NKX2.8; Nkx2-9 Summary The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all