CDKN2B-AS1, Official Symbol CDKN2B-AS1provided by HGNC Official Full Name CDKN2B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:34341 See related Ensembl:ENSG00000240498 MIM:613149; AllianceGenome:HGNC:34341 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANRIL; p15AS; PCAT12; CDKN2BAS; CDKN2B-AS; NCRNA00089 Summary This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] Expression Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.7) and 1 other tissue See more