ROBO2, Official Symbol ROBO2provided by HGNC Official Full Name roundabout guidance receptor 2provided by HGNC Primary source HGNC:HGNC:10250 See related Ensembl:ENSG00000185008 MIM:602431; AllianceGenome:HGNC:10250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAX3 Summary The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues See more Orthologs mouse all