LMTK2, Official Symbol LMTK2provided by HGNC Official Full Name lemur tyrosine kinase 2provided by HGNC Primary source HGNC:HGNC:17880 See related Ensembl:ENSG00000164715 MIM:610989; AllianceGenome:HGNC:17880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100 Summary The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in brain (RPKM 11.9), colon (RPKM 7.7) and 25 other tissues See more Orthologs mouse all