RUNX3, Official Symbol RUNX3provided by HGNC Official Full Name RUNX family transcription factor 3provided by HGNC Primary source HGNC:HGNC:10473 See related Ensembl:ENSG00000020633 MIM:600210; AllianceGenome:HGNC:10473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AML2; CBFA3; PEBP2aC Summary This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Biased expression in bone marrow (RPKM 19.5), spleen (RPKM 16.7) and 12 other tissues See more Orthologs mouse all