CYP3A7-CYP3A51P, Official Symbol CYP3A7-CYP3A51Pprovided by HGNC Official Full Name CYP3A7-CYP3A51P readthroughprovided by HGNC Primary source HGNC:HGNC:51504 See related Ensembl:ENSG00000282301 AllianceGenome:HGNC:51504 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP3A7; CYPIIIA7; CYP3A7.1L; CYP3A7-3AP1; CYP3A7-CYP3AP1 Summary This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015] Expression Biased expression in liver (RPKM 21.3), gall bladder (RPKM 4.5) and 4 other tissues See more