SEMA3F, Official Symbol SEMA3Fprovided by HGNC Official Full Name semaphorin 3Fprovided by HGNC Primary source HGNC:HGNC:10728 See related Ensembl:ENSG00000001617 MIM:601124; AllianceGenome:HGNC:10728 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEMA4; SEMAK; SEMA-IV Summary This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Broad expression in skin (RPKM 21.7), esophagus (RPKM 16.4) and 19 other tissues See more Orthologs mouse all