EIF2S2, Official Symbol EIF2S2provided by HGNC Official Full Name eukaryotic translation initiation factor 2 subunit betaprovided by HGNC Primary source HGNC:HGNC:3266 See related Ensembl:ENSG00000125977 MIM:603908; AllianceGenome:HGNC:3266 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta Summary Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in placenta (RPKM 24.2), thyroid (RPKM 22.6) and 25 other tissues See more Orthologs mouse all