CNP, Official Symbol CNPprovided by HGNC Official Full Name 2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by HGNC Primary source HGNC:HGNC:2158 See related Ensembl:ENSG00000173786 MIM:123830; AllianceGenome:HGNC:2158 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNP1; HLD20 Summary Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in several cellular components, including extracellular space; microtubule; and plasma membrane. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018] Expression Broad expression in brain (RPKM 130.3), kidney (RPKM 16.0) and 18 other tissues See more Orthologs mouse all