PREX1, Official Symbol PREX1provided by HGNC Official Full Name phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1provided by HGNC Primary source HGNC:HGNC:32594 See related Ensembl:ENSG00000124126 MIM:606905; AllianceGenome:HGNC:32594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P-REX1 Summary The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 30.0), brain (RPKM 23.2) and 23 other tissues See more Orthologs mouse all