TFR2, Official Symbol TFR2provided by HGNC Official Full Name transferrin receptor 2provided by HGNC Primary source HGNC:HGNC:11762 See related Ensembl:ENSG00000106327 MIM:604720; AllianceGenome:HGNC:11762 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HFE3; TFRC2 Summary This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] Expression Restricted expression toward liver (RPKM 143.5) See more Orthologs mouse all