ARHGDIA, Official Symbol ARHGDIAprovided by HGNC Official Full Name Rho GDP dissociation inhibitor alphaprovided by HGNC Primary source HGNC:HGNC:678 See related Ensembl:ENSG00000141522 MIM:601925; AllianceGenome:HGNC:678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e Summary This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in colon (RPKM 69.2), fat (RPKM 67.4) and 25 other tissues See more Orthologs mouse all