HLA-E, Official Symbol HLA-Eprovided by HGNC Official Full Name major histocompatibility complex, class I, Eprovided by HGNC Primary source HGNC:HGNC:4962 See related Ensembl:ENSG00000204592 MIM:143010; AllianceGenome:HGNC:4962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as QA1; HLA-6.2 Summary HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 452.2), lung (RPKM 398.4) and 24 other tissues See more Orthologs all