SIRPA, Official Symbol SIRPAprovided by HGNC Official Full Name signal regulatory protein alphaprovided by HGNC Primary source HGNC:HGNC:9662 See related Ensembl:ENSG00000198053 MIM:602461; AllianceGenome:HGNC:9662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1 Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues See more Orthologs mouse all