HOXA5, Official Symbol HOXA5provided by HGNC Official Full Name homeobox A5provided by HGNC Primary source HGNC:HGNC:5106 See related Ensembl:ENSG00000106004 MIM:142952; AllianceGenome:HGNC:5106 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX1; HOX1C; HOX1.3 Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 48.1), lung (RPKM 14.3) and 8 other tissues See more Orthologs mouse all