CAMLG, Official Symbol CAMLGprovided by HGNC Official Full Name calcium modulating ligandprovided by HGNC Primary source HGNC:HGNC:1471 See related Ensembl:ENSG00000164615 MIM:601118; AllianceGenome:HGNC:1471 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAML; GET2; CDG2Z Summary The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 22.3), ovary (RPKM 21.6) and 25 other tissues See more Orthologs mouse all