PRSS1, Official Symbol PRSS1provided by HGNC Official Full Name serine protease 1provided by HGNC Primary source HGNC:HGNC:9475 See related Ensembl:ENSG00000204983 MIM:276000; AllianceGenome:HGNC:9475 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP1; TRY1; TRY4; TRYP1 Summary This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008] Expression Restricted expression toward pancreas (RPKM 45120.4) See more Orthologs all