PRKG2, Official Symbol PRKG2provided by HGNC Official Full Name protein kinase cGMP-dependent 2provided by HGNC Primary source HGNC:HGNC:9416 See related Ensembl:ENSG00000138669 MIM:601591; AllianceGenome:HGNC:9416 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMD4; PKG2; SMDP; cGK2; cGKII; PRKGR2 Summary This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018] Expression Biased expression in prostate (RPKM 4.2), small intestine (RPKM 4.1) and 11 other tissues See more Orthologs mouse all