CNGA1, Official Symbol CNGA1provided by HGNC Official Full Name cyclic nucleotide gated channel subunit alpha 1provided by HGNC Primary source HGNC:HGNC:2148 See related Ensembl:ENSG00000198515 MIM:123825; AllianceGenome:HGNC:2148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha Summary The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Multiple transcript variants have been found for this gene. [provided by RefSeq, Oct 2019] Expression Broad expression in liver (RPKM 2.5), small intestine (RPKM 1.6) and 17 other tissues See more Orthologs mouse all