GRB10, Official Symbol GRB10provided by HGNC Official Full Name growth factor receptor bound protein 10provided by HGNC Primary source HGNC:HGNC:4564 See related Ensembl:ENSG00000106070 MIM:601523; AllianceGenome:HGNC:4564 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSS; IRBP; MEG1; GRB-IR; Grb-10 Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues See more Orthologs mouse all