HOXB8, Official Symbol HOXB8provided by HGNC Official Full Name homeobox B8provided by HGNC Primary source HGNC:HGNC:5119 See related Ensembl:ENSG00000120068 MIM:142963; AllianceGenome:HGNC:5119 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX2; HOX2D; Hox-2.4 Summary This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 4.3), colon (RPKM 4.2) and 7 other tissues See more Orthologs mouse all