HAND2, Official Symbol HAND2provided by HGNC Official Full Name heart and neural crest derivatives expressed 2provided by HGNC Primary source HGNC:HGNC:4808 See related Ensembl:ENSG00000164107 MIM:602407; AllianceGenome:HGNC:4808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hed; dHand; DHAND2; Thing2; bHLHa26 Summary The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 25.0), adrenal (RPKM 21.4) and 12 other tissues See more Orthologs mouse all