PELI3, Official Symbol PELI3provided by HGNC Official Full Name pellino E3 ubiquitin protein ligase family member 3provided by HGNC Primary source HGNC:HGNC:30010 See related Ensembl:ENSG00000174516 MIM:609827; AllianceGenome:HGNC:30010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] Expression Ubiquitous expression in brain (RPKM 6.1), ovary (RPKM 4.8) and 24 other tissues See more Orthologs mouse all