DAND5, Official Symbol DAND5provided by HGNC Official Full Name DAN domain BMP antagonist family member 5provided by HGNC Primary source HGNC:HGNC:26780 See related Ensembl:ENSG00000179284 MIM:609068; AllianceGenome:HGNC:26780 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3 Summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 2.6), brain (RPKM 0.4) and 1 other tissue See more Orthologs mouse all