BCL2L2, Official Symbol BCL2L2provided by HGNC Official Full Name BCL2 like 2provided by HGNC Primary source HGNC:HGNC:995 See related Ensembl:ENSG00000129473 MIM:601931; AllianceGenome:HGNC:995 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCLW; BCL-W; PPP1R51; BCL2-L-2 Summary This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in brain (RPKM 35.0), fat (RPKM 31.5) and 25 other tissues See more Orthologs all