SARDH, Official Symbol SARDHprovided by HGNC Official Full Name sarcosine dehydrogenaseprovided by HGNC Primary source HGNC:HGNC:10536 See related Ensembl:ENSG00000123453 MIM:604455; AllianceGenome:HGNC:10536 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAR; SDH; SARD; BPR-2; DMGDHL1 Summary This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008] Expression Biased expression in liver (RPKM 15.5), kidney (RPKM 6.4) and 6 other tissues See more Orthologs mouse all