APLN, Official Symbol APLNprovided by HGNC Official Full Name apelinprovided by HGNC Primary source HGNC:HGNC:16665 See related Ensembl:ENSG00000171388 MIM:300297; AllianceGenome:HGNC:16665 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APEL; XNPEP2 Summary This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016] Expression Biased expression in placenta (RPKM 42.1), lung (RPKM 12.5) and 5 other tissues See more Orthologs mouse all