CTNNA1, Official Symbol CTNNA1provided by HGNC Official Full Name catenin alpha 1provided by HGNC Primary source HGNC:HGNC:2509 See related Ensembl:ENSG00000044115 MIM:116805; AllianceGenome:HGNC:2509 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDBS2; MDPT2; CAP102 Summary This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016] Expression Ubiquitous expression in esophagus (RPKM 69.8), lung (RPKM 58.9) and 25 other tissues See more Orthologs mouse all