PPP1R12B, Official Symbol PPP1R12Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 12Bprovided by HGNC Primary source HGNC:HGNC:7619 See related Ensembl:ENSG00000077157 MIM:603768; AllianceGenome:HGNC:7619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYPT2; PP1bp55 Summary Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011] Expression Broad expression in heart (RPKM 45.5), endometrium (RPKM 24.6) and 17 other tissues See more Orthologs mouse all