WFDC6, Official Symbol WFDC6provided by HGNC Official Full Name WAP four-disulfide core domain 6provided by HGNC Primary source HGNC:HGNC:16164 See related Ensembl:ENSG00000243543 AllianceGenome:HGNC:16164 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP6; C20orf171; HEL-S-295; dJ461P17.11 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010] Expression Restricted expression toward testis (RPKM 26.2) See more Orthologs all