DENND1A, Official Symbol DENND1Aprovided by HGNC Official Full Name DENN domain containing 1Aprovided by HGNC Primary source HGNC:HGNC:29324 See related Ensembl:ENSG00000119522 MIM:613633; AllianceGenome:HGNC:29324 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM31A; KIAA1608 Summary Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in spleen (RPKM 4.6), kidney (RPKM 4.6) and 25 other tissues See more Orthologs mouse all