CASP6, Official Symbol CASP6provided by HGNC Official Full Name caspase 6provided by HGNC Primary source HGNC:HGNC:1507 See related Ensembl:ENSG00000138794 MIM:601532; AllianceGenome:HGNC:1507 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCH2; CSP-6; caspase-6 Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015] Expression Broad expression in duodenum (RPKM 18.7), colon (RPKM 18.7) and 25 other tissues See more Orthologs mouse all