MYH11, Official Symbol MYH11provided by HGNC Official Full Name myosin heavy chain 11provided by HGNC Primary source HGNC:HGNC:7569 See related Ensembl:ENSG00000133392 MIM:160745; AllianceGenome:HGNC:7569 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAT4; FAA4; SMHC; SMMHC; VSCM2; SMMS-1 Summary The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022] Expression Biased expression in esophagus (RPKM 836.6), prostate (RPKM 661.4) and 12 other tissues See more Orthologs mouse all