ITGB8, Official Symbol ITGB8provided by HGNC Official Full Name integrin subunit beta 8provided by HGNC Primary source HGNC:HGNC:6163 See related Ensembl:ENSG00000105855 MIM:604160; AllianceGenome:HGNC:6163 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 12.1), brain (RPKM 11.6) and 19 other tissues See more Orthologs mouse all