CYSLTR1, Official Symbol CYSLTR1provided by HGNC Official Full Name cysteinyl leukotriene receptor 1provided by HGNC Primary source HGNC:HGNC:17451 See related Ensembl:ENSG00000173198 MIM:300201; AllianceGenome:HGNC:17451 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYSLT1; CYSLTR; CYSLT1R; HMTMF81 Summary This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues See more Orthologs mouse all