CENPI, Official Symbol CENPIprovided by HGNC Official Full Name centromere protein Iprovided by HGNC Primary source HGNC:HGNC:3968 See related Ensembl:ENSG00000102384 MIM:300065; AllianceGenome:HGNC:3968 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRPR1; CENP-I; FSHPRH1 Summary This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016] Expression Broad expression in lymph node (RPKM 1.1), appendix (RPKM 0.7) and 22 other tissues See more Orthologs mouse all