TLR5, Official Symbol TLR5provided by HGNC Official Full Name toll like receptor 5provided by HGNC Primary source HGNC:HGNC:11851 See related Ensembl:ENSG00000187554 MIM:603031; AllianceGenome:HGNC:11851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLE1; TIL3; SLEB1; MELIOS Summary This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] Expression Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more Orthologs mouse all