SART1, Official Symbol SART1provided by HGNC Official Full Name spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNPprovided by HGNC Primary source HGNC:HGNC:10538 See related Ensembl:ENSG00000175467 MIM:605941; AllianceGenome:HGNC:10538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAF; Ara1; HOMS1; Snu66; SART1259; SNRNP110 Summary This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 16.1), spleen (RPKM 14.5) and 25 other tissues See more Orthologs mouse all