NFKBIB, Official Symbol NFKBIBprovided by HGNC Official Full Name NFKB inhibitor betaprovided by HGNC Primary source HGNC:HGNC:7798 See related Ensembl:ENSG00000104825 MIM:604495; AllianceGenome:HGNC:7798 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKBB; TRIP9 Summary The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011] Expression Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues See more Orthologs mouse all