BMP5, Official Symbol BMP5provided by HGNC Official Full Name bone morphogenetic protein 5provided by HGNC Primary source HGNC:HGNC:1072 See related Ensembl:ENSG00000112175 MIM:112265; AllianceGenome:HGNC:1072 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016] Expression Biased expression in placenta (RPKM 11.7), lung (RPKM 3.1) and 7 other tissues See more Orthologs mouse all