HOXB4, Official Symbol HOXB4provided by HGNC Official Full Name homeobox B4provided by HGNC Primary source HGNC:HGNC:5115 See related Ensembl:ENSG00000182742 MIM:142965; AllianceGenome:HGNC:5115 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX2; HOX2F; HOX-2.6 Summary This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 4.1), lung (RPKM 2.6) and 19 other tissues See more Orthologs mouse all