ASPN, Official Symbol ASPNprovided by HGNC Official Full Name asporinprovided by HGNC Primary source HGNC:HGNC:14872 See related Ensembl:ENSG00000106819 MIM:608135; AllianceGenome:HGNC:14872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OS3; PLAP1; PLAP-1; SLRR1C Summary This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014] Annotation information Annotation category: suggests misassembly Expression Broad expression in gall bladder (RPKM 43.4), endometrium (RPKM 40.7) and 17 other tissues See more Orthologs mouse all