NEDD9, Official Symbol NEDD9provided by HGNC Official Full Name neural precursor cell expressed, developmentally down-regulated 9provided by HGNC Primary source HGNC:HGNC:7733 See related Ensembl:ENSG00000111859 MIM:602265; AllianceGenome:HGNC:7733 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAS2; CASL; HEF1; CAS-L; CASS2 Summary The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Broad expression in lung (RPKM 35.3), placenta (RPKM 25.4) and 22 other tissues See more Orthologs mouse all