CDK5R1, Official Symbol CDK5R1provided by HGNC Official Full Name cyclin dependent kinase 5 regulatory subunit 1provided by HGNC Primary source HGNC:HGNC:1775 See related Ensembl:ENSG00000176749 MIM:603460; AllianceGenome:HGNC:1775 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a Summary The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 36.6), lymph node (RPKM 6.6) and 5 other tissues See more Orthologs mouse all