PIAS2, Official Symbol PIAS2provided by HGNC Official Full Name protein inhibitor of activated STAT 2provided by HGNC Primary source HGNC:HGNC:17311 See related Ensembl:ENSG00000078043 MIM:603567; AllianceGenome:HGNC:17311 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4 Summary This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017] Expression Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more Orthologs mouse all