PDE4B, Official Symbol PDE4Bprovided by HGNC Official Full Name phosphodiesterase 4Bprovided by HGNC Primary source HGNC:HGNC:8781 See related Ensembl:ENSG00000184588 MIM:600127; AllianceGenome:HGNC:8781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPDE4; PDEIVB Summary This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] Expression Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues See more Orthologs mouse all