LLGL2, Official Symbol LLGL2provided by HGNC Official Full Name LLGL scribble cell polarity complex component 2provided by HGNC Primary source HGNC:HGNC:6629 See related Ensembl:ENSG00000073350 MIM:618483; AllianceGenome:HGNC:6629 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HGL; LGL2; Hugl-2 Summary The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in stomach (RPKM 24.5), colon (RPKM 24.0) and 22 other tissues See more Orthologs mouse all