PTPN4, Official Symbol PTPN4provided by HGNC Official Full Name protein tyrosine phosphatase non-receptor type 4provided by HGNC Primary source HGNC:HGNC:9656 See related Ensembl:ENSG00000088179 MIM:176878; AllianceGenome:HGNC:9656 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEG; PTPMEG; PTPMEG1 Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 7.2), brain (RPKM 5.8) and 24 other tissues See more Orthologs mouse all