CYP4F3, Official Symbol CYP4F3provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 3provided by HGNC Primary source HGNC:HGNC:2646 See related Ensembl:ENSG00000186529 MIM:601270; AllianceGenome:HGNC:2646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPF3; CYP4F; LTB4H; CYPIVF3 Summary This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019] Expression Biased expression in liver (RPKM 51.6), bone marrow (RPKM 29.9) and 6 other tissues See more Orthologs all