PTGDS, Official Symbol PTGDSprovided by HGNC Official Full Name prostaglandin D2 synthaseprovided by HGNC Primary source HGNC:HGNC:9592 See related Ensembl:ENSG00000107317 MIM:176803; AllianceGenome:HGNC:9592 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS Summary The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues See more Orthologs mouse all