UCHL1, Official Symbol UCHL1provided by HGNC Official Full Name ubiquitin C-terminal hydrolase L1provided by HGNC Primary source HGNC:HGNC:12513 See related Ensembl:ENSG00000154277 MIM:191342; AllianceGenome:HGNC:12513 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDGOA; PARK5; PGP95; SPG79; PGP9.5; SPG79A; UCHL-1; Uch-L1; HEL-117; PGP 9.5; HEL-S-53 Summary The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] Expression Biased expression in brain (RPKM 389.7), adrenal (RPKM 70.8) and 2 other tissues See more Orthologs mouse all