TRIM3, Official Symbol TRIM3provided by HGNC Official Full Name tripartite motif containing 3provided by HGNC Primary source HGNC:HGNC:10064 See related Ensembl:ENSG00000110171 MIM:605493; AllianceGenome:HGNC:10064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BERP; HAC1; RNF22; RNF97 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more Orthologs mouse all