G6PC2, Official Symbol G6PC2provided by HGNC Official Full Name glucose-6-phosphatase catalytic subunit 2provided by HGNC Primary source HGNC:HGNC:28906 See related Ensembl:ENSG00000152254 MIM:608058; AllianceGenome:HGNC:28906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGRP Summary This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in pancreas (RPKM 3.9), testis (RPKM 0.4) and 1 other tissue See more Orthologs mouse all