RAE1, Official Symbol RAE1provided by HGNC Official Full Name ribonucleic acid export 1provided by HGNC Primary source HGNC:HGNC:9828 See related Ensembl:ENSG00000101146 MIM:603343; AllianceGenome:HGNC:9828 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1 Summary Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 35.7), bone marrow (RPKM 13.2) and 24 other tissues See more Orthologs mouse all