SMG9, Official Symbol SMG9provided by HGNC Official Full Name SMG9 nonsense mediated mRNA decay factorprovided by HGNC Primary source HGNC:HGNC:25763 See related Ensembl:ENSG00000105771 MIM:613176; AllianceGenome:HGNC:25763 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBMS; NEDITPO; C19orf61; F17127_1 Summary This gene encodes a regulatory subunit of the SMG1 complex, which plays a critical role in nonsense-mediated mRNA decay (NMD). Binding of the encoded protein to the SMG1 complex kinase scaffold protein results in the inhibition of its kinase activity. Mutations in this gene cause a multiple congenital anomaly syndrome in human patients, characterized by brain malformation, congenital heart disease and other features. [provided by RefSeq, Jul 2016] Expression Broad expression in testis (RPKM 13.7), lymph node (RPKM 6.7) and 24 other tissues See more Orthologs mouse all