EGLN3, Official Symbol EGLN3provided by HGNC Official Full Name egl-9 family hypoxia inducible factor 3provided by HGNC Primary source HGNC:HGNC:14661 See related Ensembl:ENSG00000129521 MIM:606426; AllianceGenome:HGNC:14661 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PHD3; HIFPH3; HIFP4H3 Summary Enables peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Located in cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 31.3), heart (RPKM 27.7) and 16 other tissues See more Orthologs mouse all