ADAMTS14, Official Symbol ADAMTS14provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 14provided by HGNC Primary source HGNC:HGNC:14899 See related Ensembl:ENSG00000138316 MIM:607506; AllianceGenome:HGNC:14899 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016] Expression Biased expression in gall bladder (RPKM 3.7), placenta (RPKM 3.6) and 13 other tissues See more Orthologs mouse all