UPK1A, Official Symbol UPK1Aprovided by HGNC Official Full Name uroplakin 1Aprovided by HGNC Primary source HGNC:HGNC:12577 See related Ensembl:ENSG00000105668 MIM:611557; AllianceGenome:HGNC:12577 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UP1A; UPIA; UPKA; TSPAN21 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] Expression Biased expression in urinary bladder (RPKM 34.0), esophagus (RPKM 7.5) and 2 other tissues See more Orthologs mouse all