BRF1, Official Symbol BRF1provided by HGNC Official Full Name BRF1 RNA polymerase III transcription initiation factor subunitprovided by HGNC Primary source HGNC:HGNC:11551 See related Ensembl:ENSG00000185024 MIM:604902; AllianceGenome:HGNC:11551 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRF; CFDS; hBRF; BRF-1; GTF3B; TAF3C; TAF3B2; TF3B90; TAFIII90; TFIIIB90; HEL-S-76p Summary This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011] Expression Ubiquitous expression in fat (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues See more Orthologs mouse all