RAPGEF4, Official Symbol RAPGEF4provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 4provided by HGNC Primary source HGNC:HGNC:16626 See related Ensembl:ENSG00000091428 MIM:606058; AllianceGenome:HGNC:16626 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII Summary Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 37.0), adrenal (RPKM 17.3) and 12 other tissues See more Orthologs mouse all