PURA, Official Symbol PURAprovided by HGNC Official Full Name purine rich element binding protein Aprovided by HGNC Primary source HGNC:HGNC:9701 See related Ensembl:ENSG00000185129 MIM:600473; AllianceGenome:HGNC:9701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PUR1; MRD31; NEDRIHF; PURALPHA; PUR-ALPHA Summary This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] Orthologs mouse all