AKT2, Official Symbol AKT2provided by HGNC Official Full Name AKT serine/threonine kinase 2provided by HGNC Primary source HGNC:HGNC:392 See related Ensembl:ENSG00000105221 MIM:164731; AllianceGenome:HGNC:392 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA Summary This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019] Expression Ubiquitous expression in thyroid (RPKM 30.9), fat (RPKM 28.8) and 25 other tissues See more Orthologs mouse all