HLA-F, Official Symbol HLA-Fprovided by HGNC Official Full Name major histocompatibility complex, class I, Fprovided by HGNC Primary source HGNC:HGNC:4963 See related Ensembl:ENSG00000204642 MIM:143110; AllianceGenome:HGNC:4963 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLAF; CDA12; HLA-5.4; HLA-CDA12 Summary This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 31.0), lymph node (RPKM 20.6) and 24 other tissues See more Orthologs all