ARPC1B, Official Symbol ARPC1Bprovided by HGNC Official Full Name actin related protein 2/3 complex subunit 1Bprovided by HGNC Primary source HGNC:HGNC:704 See related Ensembl:ENSG00000130429 MIM:604223; AllianceGenome:HGNC:704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC41; IMD71; PLTEID; p40-ARC; p41-ARC Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011] Expression Broad expression in spleen (RPKM 111.2), appendix (RPKM 92.6) and 24 other tissues See more Orthologs mouse all