CYP2C19, Official Symbol CYP2C19provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 19provided by HGNC Primary source HGNC:HGNC:2621 See related Ensembl:ENSG00000165841 MIM:124020; AllianceGenome:HGNC:2621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 80.1), duodenum (RPKM 37.5) and 3 other tissues See more Orthologs all