PARVB, Official Symbol PARVBprovided by HGNC Official Full Name parvin betaprovided by HGNC Primary source HGNC:HGNC:14653 See related Ensembl:ENSG00000188677 MIM:608121; AllianceGenome:HGNC:14653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-56 Summary This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in fat (RPKM 14.3), heart (RPKM 12.4) and 24 other tissues See more Orthologs mouse all