RELA, Official Symbol RELAprovided by HGNC Official Full Name RELA proto-oncogene, NF-kB subunitprovided by HGNC Primary source HGNC:HGNC:9955 See related Ensembl:ENSG00000173039 MIM:164014; AllianceGenome:HGNC:9955 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p65; CMCU; NFKB3; AIF3BL3 Summary NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in bone marrow (RPKM 28.6), spleen (RPKM 25.4) and 25 other tissues See more Orthologs mouse all