BAG2, Official Symbol BAG2provided by HGNC Official Full Name BAG cochaperone 2provided by HGNC Primary source HGNC:HGNC:938 See related Ensembl:ENSG00000112208 MIM:603882; AllianceGenome:HGNC:938 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAG-2; dJ417I1.2 Summary BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues See more Orthologs mouse all