TFB1M, Official Symbol TFB1Mprovided by HGNC Official Full Name transcription factor B1, mitochondrialprovided by HGNC Primary source HGNC:HGNC:17037 See related Ensembl:ENSG00000029639 MIM:607033; AllianceGenome:HGNC:17037 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI75; mtTFB; CGI-75; mtTFB1 Summary The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 2.2), adrenal (RPKM 1.8) and 25 other tissues See more Orthologs mouse all