TLX1, Official Symbol TLX1provided by HGNC Official Full Name T cell leukemia homeobox 1provided by HGNC Primary source HGNC:HGNC:5056 See related Ensembl:ENSG00000107807 MIM:186770; AllianceGenome:HGNC:5056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCL3; HOX11 Summary This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] Expression Biased expression in spleen (RPKM 14.4) and salivary gland (RPKM 3.2) See more Orthologs mouse all