CD3G, Official Symbol CD3Gprovided by HGNC Official Full Name CD3 gamma subunit of T-cell receptor complexprovided by HGNC Primary source HGNC:HGNC:1675 See related Ensembl:ENSG00000160654 MIM:186740; AllianceGenome:HGNC:1675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3G; IMD17; CD3GAMMA; CD3-GAMMA Summary The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues See more Orthologs mouse all