PROC, Official Symbol PROCprovided by HGNC Official Full Name protein C, inactivator of coagulation factors Va and VIIIaprovided by HGNC Primary source HGNC:HGNC:9451 See related Ensembl:ENSG00000115718 MIM:612283; AllianceGenome:HGNC:9451 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PC; APC; PROC1; THPH3; THPH4 Summary This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009] Annotation information Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019] Expression Biased expression in liver (RPKM 55.9) and kidney (RPKM 6.8) See more Orthologs mouse all