EFNA1, Official Symbol EFNA1provided by HGNC Official Full Name ephrin A1provided by HGNC Primary source HGNC:HGNC:3221 See related Ensembl:ENSG00000169242 MIM:191164; AllianceGenome:HGNC:3221 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B61; EFL1; GMAN; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4 Summary This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 65.2), lung (RPKM 54.9) and 22 other tissues See more Orthologs mouse all