HMOX2, Official Symbol HMOX2provided by HGNC Official Full Name heme oxygenase 2provided by HGNC Primary source HGNC:HGNC:5014 See related Ensembl:ENSG00000103415 MIM:141251; AllianceGenome:HGNC:5014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HO-2 Summary Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] Expression Ubiquitous expression in testis (RPKM 23.0), brain (RPKM 16.1) and 25 other tissues See more Orthologs mouse all