TYW1, Official Symbol TYW1provided by HGNC Official Full Name tRNA-yW synthesizing protein 1 homologprovided by HGNC Primary source HGNC:HGNC:25598 See related Ensembl:ENSG00000198874 MIM:611243; AllianceGenome:HGNC:25598 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TYW1A; RSAFD1; YPL207W Summary Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in thyroid (RPKM 5.7), ovary (RPKM 5.0) and 25 other tissues See more Orthologs all