GADD45B, Official Symbol GADD45Bprovided by HGNC Official Full Name growth arrest and DNA damage inducible betaprovided by HGNC Primary source HGNC:HGNC:4096 See related Ensembl:ENSG00000099860 MIM:604948; AllianceGenome:HGNC:4096 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYD118; GADD45BETA Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 112.2), bone marrow (RPKM 99.7) and 23 other tissues See more Orthologs mouse all