SUV39H1, Official Symbol SUV39H1provided by HGNC Official Full Name SUV39H1 histone lysine methyltransferaseprovided by HGNC Primary source HGNC:HGNC:11479 See related Ensembl:ENSG00000101945 MIM:300254; AllianceGenome:HGNC:11479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MG44; KMT1A; SUV39H; H3-K9-HMTase 1 Summary This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in bone marrow (RPKM 4.9), lymph node (RPKM 3.6) and 24 other tissues See more Orthologs mouse all