LNX1, Official Symbol LNX1provided by HGNC Official Full Name ligand of numb-protein X 1provided by HGNC Primary source HGNC:HGNC:6657 See related Ensembl:ENSG00000072201 MIM:609732; AllianceGenome:HGNC:6657 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LNX; MPDZ; PDZRN2 Summary This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 10.1), esophagus (RPKM 8.0) and 25 other tissues See more Orthologs mouse all