TNFAIP6, Official Symbol TNFAIP6provided by HGNC Official Full Name TNF alpha induced protein 6provided by HGNC Primary source HGNC:HGNC:11898 See related Ensembl:ENSG00000123610 MIM:600410; AllianceGenome:HGNC:11898 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSG6; TSG-6 Summary The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010] Expression Biased expression in appendix (RPKM 17.8), gall bladder (RPKM 12.0) and 11 other tissues See more Orthologs mouse all