PJA1, Official Symbol PJA1provided by HGNC Official Full Name praja ring finger ubiquitin ligase 1provided by HGNC Primary source HGNC:HGNC:16648 See related Ensembl:ENSG00000181191 MIM:300420; AllianceGenome:HGNC:16648 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF70; PRAJA1 Summary This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Broad expression in brain (RPKM 23.0), testis (RPKM 16.5) and 24 other tissues See more Orthologs mouse all