TMEM127, Official Symbol TMEM127provided by HGNC Official Full Name transmembrane protein 127provided by HGNC Primary source HGNC:HGNC:26038 See related Ensembl:ENSG00000135956 MIM:613403; AllianceGenome:HGNC:26038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a transmembrane protein with four predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2022] Expression Ubiquitous expression in heart (RPKM 15.7), esophagus (RPKM 13.6) and 25 other tissues See more Orthologs mouse all