RPTOR, Official Symbol RPTORprovided by HGNC Official Full Name regulatory associated protein of MTOR complex 1provided by HGNC Primary source HGNC:HGNC:30287 See related Ensembl:ENSG00000141564 MIM:607130; AllianceGenome:HGNC:30287 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KOG1; Mip1 Summary This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 4.5) and 25 other tissues See more Orthologs mouse all