SYT8, Official Symbol SYT8provided by HGNC Official Full Name synaptotagmin 8provided by HGNC Primary source HGNC:HGNC:19264 See related Ensembl:ENSG00000149043 MIM:607719; AllianceGenome:HGNC:19264 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014] Expression Biased expression in skin (RPKM 28.8), urinary bladder (RPKM 7.9) and 5 other tissues See more Orthologs mouse all