METTL1, Official Symbol METTL1provided by HGNC Official Full Name methyltransferase 1, tRNA methylguanosineprovided by HGNC Primary source HGNC:HGNC:7030 See related Ensembl:ENSG00000037897 MIM:604466; AllianceGenome:HGNC:7030 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM8; TRMT8; C12orf1; YDL201w Summary This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 7.6), thyroid (RPKM 7.3) and 25 other tissues See more Orthologs mouse all