ITGAX, Official Symbol ITGAXprovided by HGNC Official Full Name integrin subunit alpha Xprovided by HGNC Primary source HGNC:HGNC:6152 See related Ensembl:ENSG00000140678 MIM:151510; AllianceGenome:HGNC:6152 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD11C; SLEB6 Summary This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Biased expression in spleen (RPKM 34.3), appendix (RPKM 32.4) and 12 other tissues See more Orthologs mouse all