XPO1, Official Symbol XPO1provided by HGNC Official Full Name exportin 1provided by HGNC Primary source HGNC:HGNC:12825 See related Ensembl:ENSG00000082898 MIM:602559; AllianceGenome:HGNC:12825 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as emb; CRM1; exp1; CRM-1 Summary This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in testis (RPKM 38.6), lymph node (RPKM 33.8) and 25 other tissues See more Orthologs mouse all