CACNA1B, Official Symbol CACNA1Bprovided by HGNC Official Full Name calcium voltage-gated channel subunit alpha1 Bprovided by HGNC Primary source HGNC:HGNC:1389 See related Ensembl:ENSG00000148408 MIM:601012; AllianceGenome:HGNC:1389 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIII; CACNN; DYT23; Cav2.2; NEDNEH; CACNL1A5 Summary The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Biased expression in brain (RPKM 4.9), testis (RPKM 2.2) and 1 other tissue See more Orthologs mouse all