CA11, Official Symbol CA11provided by HGNC Official Full Name carbonic anhydrase 11provided by HGNC Primary source HGNC:HGNC:1370 See related Ensembl:ENSG00000063180 MIM:604644; AllianceGenome:HGNC:1370 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CA-RP; CA-XI; CARP-2; CARPX1; CA-RP II Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 69.9), ovary (RPKM 14.7) and 2 other tissues See more Orthologs mouse all