ACSS2, Official Symbol ACSS2provided by HGNC Official Full Name acyl-CoA synthetase short chain family member 2provided by HGNC Primary source HGNC:HGNC:15814 See related Ensembl:ENSG00000131069 MIM:605832; AllianceGenome:HGNC:15814 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS; ACSA; ACAS2; ACECS; AceCS1; dJ1161H23.1 Summary This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] Expression Broad expression in fat (RPKM 49.2), duodenum (RPKM 47.1) and 24 other tissues See more Orthologs mouse all