FAT1, Official Symbol FAT1provided by HGNC Official Full Name FAT atypical cadherin 1provided by HGNC Primary source HGNC:HGNC:3595 See related Ensembl:ENSG00000083857 MIM:600976; AllianceGenome:HGNC:3595 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAT; ME5; CDHF7; CDHR8; hFat1 Summary This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 17.7), kidney (RPKM 13.3) and 21 other tissues See more Orthologs mouse all