PHLPP1, Official Symbol PHLPP1provided by HGNC Official Full Name PH domain and leucine rich repeat protein phosphatase 1provided by HGNC Primary source HGNC:HGNC:20610 See related Ensembl:ENSG00000081913 MIM:609396; AllianceGenome:HGNC:20610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCOP; PHLPP; PPM3A; PLEKHE1 Summary This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011] Expression Broad expression in brain (RPKM 17.2), testis (RPKM 8.3) and 25 other tissues See more Orthologs mouse all