S100A1, Official Symbol S100A1provided by HGNC Official Full Name S100 calcium binding protein A1provided by HGNC Primary source HGNC:HGNC:10486 See related Ensembl:ENSG00000160678 MIM:176940; AllianceGenome:HGNC:10486 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S100; S100A; S100-alpha Summary The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 773.3), salivary gland (RPKM 114.1) and 3 other tissues See more Orthologs mouse all