RHBDL2, Official Symbol RHBDL2provided by HGNC Official Full Name rhomboid like 2provided by HGNC Primary source HGNC:HGNC:16083 See related Ensembl:ENSG00000158315 MIM:608962; AllianceGenome:HGNC:16083 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRP2 Summary The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] Expression Biased expression in colon (RPKM 9.9), skin (RPKM 6.4) and 10 other tissues See more Orthologs mouse all