CD226, Official Symbol CD226provided by HGNC Official Full Name CD226 moleculeprovided by HGNC Primary source HGNC:HGNC:16961 See related Ensembl:ENSG00000150637 MIM:605397; AllianceGenome:HGNC:16961 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTA1; DNAM1; DNAM-1; TLiSA1 Summary This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues See more Orthologs mouse all