CHIT1, Official Symbol CHIT1provided by HGNC Official Full Name chitinase 1provided by HGNC Primary source HGNC:HGNC:1936 See related Ensembl:ENSG00000133063 MIM:600031; AllianceGenome:HGNC:1936 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHI3; CHIT; CHITD Summary Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012] Expression Biased expression in bone marrow (RPKM 24.2), lung (RPKM 14.0) and 1 other tissue See more Orthologs mouse all