EFNB2, Official Symbol EFNB2provided by HGNC Official Full Name ephrin B2provided by HGNC Primary source HGNC:HGNC:3227 See related Ensembl:ENSG00000125266 MIM:600527; AllianceGenome:HGNC:3227 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTKL; EPLG5; Htk-L; LERK5; ephrin-B2 Summary This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 8.5), colon (RPKM 7.4) and 23 other tissues See more Orthologs mouse all