STK10, Official Symbol STK10provided by HGNC Official Full Name serine/threonine kinase 10provided by HGNC Primary source HGNC:HGNC:11388 See related Ensembl:ENSG00000072786 MIM:603919; AllianceGenome:HGNC:11388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOK; PRO2729 Summary This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 23.3), bone marrow (RPKM 21.8) and 23 other tissues See more Orthologs mouse all