RB1, Official Symbol RB1provided by HGNC Official Full Name RB transcriptional corepressor 1provided by HGNC Primary source HGNC:HGNC:9884 See related Ensembl:ENSG00000139687 MIM:614041; AllianceGenome:HGNC:9884 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1 Summary The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 18.0), thyroid (RPKM 16.4) and 25 other tissues See more Orthologs mouse all