IGFBP4, Official Symbol IGFBP4provided by HGNC Official Full Name insulin like growth factor binding protein 4provided by HGNC Primary source HGNC:HGNC:5473 See related Ensembl:ENSG00000141753 MIM:146733; AllianceGenome:HGNC:5473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BP-4; IBP4; IGFBP-4; HT29-IGFBP Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 316.3), ovary (RPKM 298.9) and 21 other tissues See more Orthologs mouse all