DKK1, Official Symbol DKK1provided by HGNC Official Full Name dickkopf WNT signaling pathway inhibitor 1provided by HGNC Primary source HGNC:HGNC:2891 See related Ensembl:ENSG00000107984 MIM:605189; AllianceGenome:HGNC:2891 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK; DKK-1 Summary This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017] Expression Biased expression in placenta (RPKM 39.1), urinary bladder (RPKM 8.2) and 3 other tissues See more Orthologs mouse all