SDC2, Official Symbol SDC2provided by HGNC Official Full Name syndecan 2provided by HGNC Primary source HGNC:HGNC:10659 See related Ensembl:ENSG00000169439 MIM:142460; AllianceGenome:HGNC:10659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSPG; CD362; HSPG1; SYND2 Summary The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 143.2), liver (RPKM 70.5) and 19 other tissues See more Orthologs mouse all