PTPRC, Official Symbol PTPRCprovided by HGNC Official Full Name protein tyrosine phosphatase receptor type Cprovided by HGNC Primary source HGNC:HGNC:9666 See related Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105 Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] Expression Biased expression in lymph node (RPKM 119.6), appendix (RPKM 101.8) and 10 other tissues See more Orthologs mouse all