RAF1, Official Symbol RAF1provided by HGNC Official Full Name Raf-1 proto-oncogene, serine/threonine kinaseprovided by HGNC Primary source HGNC:HGNC:9829 See related Ensembl:ENSG00000132155 MIM:164760; AllianceGenome:HGNC:9829 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NS5; CRAF; Raf-1; c-Raf; CMD1NN Summary This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 34.4), heart (RPKM 32.5) and 25 other tissues See more Orthologs mouse all