HLA-G, Official Symbol HLA-Gprovided by HGNC Official Full Name major histocompatibility complex, class I, Gprovided by HGNC Primary source HGNC:HGNC:4964 See related Ensembl:ENSG00000204632 MIM:142871; AllianceGenome:HGNC:4964 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MHC-G Summary HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 29.5), colon (RPKM 14.0) and 15 other tissues See more Orthologs all