RAG1, Official Symbol RAG1provided by HGNC Official Full Name recombination activating 1provided by HGNC Primary source HGNC:HGNC:9831 See related Ensembl:ENSG00000166349 MIM:179615; AllianceGenome:HGNC:9831 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAG-1; RNF74 Summary The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 2.3), bone marrow (RPKM 1.9) and 20 other tissues See more Orthologs mouse all