GPA33, Official Symbol GPA33provided by HGNC Official Full Name glycoprotein A33provided by HGNC Primary source HGNC:HGNC:4445 See related Ensembl:ENSG00000143167 MIM:602171; AllianceGenome:HGNC:4445 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A33 Summary The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 108.1), duodenum (RPKM 69.2) and 2 other tissues See more Orthologs mouse all