PRSS12, Official Symbol PRSS12provided by HGNC Official Full Name serine protease 12provided by HGNC Primary source HGNC:HGNC:9477 See related Ensembl:ENSG00000164099 MIM:606709; AllianceGenome:HGNC:9477 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT1; BSSP3; BSSP-3 Summary This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017] Expression Broad expression in testis (RPKM 7.3), gall bladder (RPKM 6.2) and 18 other tissues See more Orthologs mouse all