RLN2, Official Symbol RLN2provided by HGNC Official Full Name relaxin 2provided by HGNC Primary source HGNC:HGNC:10027 See related Ensembl:ENSG00000107014 MIM:179740; AllianceGenome:HGNC:10027 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2 Summary This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016] Expression Biased expression in prostate (RPKM 1.9), testis (RPKM 0.8) and 12 other tissues See more Orthologs all