CHMP4C, Official Symbol CHMP4Cprovided by HGNC Official Full Name charged multivesicular body protein 4Cprovided by HGNC Primary source HGNC:HGNC:30599 See related Ensembl:ENSG00000164695 MIM:610899; AllianceGenome:HGNC:30599 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Shax3; SNF7-3; VPS32C Summary CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] Expression Broad expression in duodenum (RPKM 19.0), small intestine (RPKM 14.8) and 19 other tissues See more Orthologs mouse all