IL1A, Official Symbol IL1Aprovided by HGNC Official Full Name interleukin 1 alphaprovided by HGNC Primary source HGNC:HGNC:5991 See related Ensembl:ENSG00000115008 MIM:147760; AllianceGenome:HGNC:5991 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Biased expression in testis (RPKM 5.2), esophagus (RPKM 4.6) and 7 other tissues See more Orthologs mouse all