DACT1, Official Symbol DACT1provided by HGNC Official Full Name dishevelled binding antagonist of beta catenin 1provided by HGNC Primary source HGNC:HGNC:17748 See related Ensembl:ENSG00000165617 MIM:607861; AllianceGenome:HGNC:17748 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPR1; TBS2; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1 Summary The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in gall bladder (RPKM 10.6), ovary (RPKM 9.1) and 22 other tissues See more Orthologs mouse all