CCL22, Official Symbol CCL22provided by HGNC Official Full Name C-C motif chemokine ligand 22provided by HGNC Primary source HGNC:HGNC:10621 See related Ensembl:ENSG00000102962 MIM:602957; AllianceGenome:HGNC:10621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1 Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014] Expression Biased expression in appendix (RPKM 7.9), lymph node (RPKM 2.9) and 10 other tissues See more Orthologs mouse all