GRIK2, Official Symbol GRIK2provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 2provided by HGNC Primary source HGNC:HGNC:4580 See related Ensembl:ENSG00000164418 MIM:138244; AllianceGenome:HGNC:4580 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2; NEDLAS Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 2.7), heart (RPKM 0.6) and 5 other tissues See more Orthologs mouse all