CYP3A43, Official Symbol CYP3A43provided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 43provided by HGNC Primary source HGNC:HGNC:17450 See related Ensembl:ENSG00000021461 MIM:606534; AllianceGenome:HGNC:17450 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Expression Biased expression in liver (RPKM 2.4), testis (RPKM 0.3) and 1 other tissue See more Orthologs all