UBQLN4, Official Symbol UBQLN4provided by HGNC Official Full Name ubiquilin 4provided by HGNC Primary source HGNC:HGNC:1237 See related Ensembl:ENSG00000160803 MIM:605440; AllianceGenome:HGNC:1237 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1U; A1Up; UBIN; CIP75; C1orf6 Summary Enables K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in cellular response to DNA damage stimulus; negative regulation of double-strand break repair via homologous recombination; and regulation of cellular catabolic process. Located in several cellular components, including autophagosome; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with cytosolic proteasome complex and nuclear proteasome complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 15.5), endometrium (RPKM 13.7) and 25 other tissues See more Orthologs mouse all