ALKBH3, Official Symbol ALKBH3provided by HGNC Official Full Name alkB homolog 3, alpha-ketoglutarate dependent dioxygenaseprovided by HGNC Primary source HGNC:HGNC:30141 See related Ensembl:ENSG00000166199 MIM:610603; AllianceGenome:HGNC:30141 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ABH3; PCA1; DEPC1; hABH3; DEPC-1 Summary The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 6.9), prostate (RPKM 6.8) and 25 other tissues See more Orthologs mouse all