PTGES, Official Symbol PTGESprovided by HGNC Official Full Name prostaglandin E synthaseprovided by HGNC Primary source HGNC:HGNC:9599 See related Ensembl:ENSG00000148344 MIM:605172; AllianceGenome:HGNC:9599 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1 Summary The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 28.7), urinary bladder (RPKM 13.8) and 12 other tissues See more Orthologs mouse all