PDCD6IP, Official Symbol PDCD6IPprovided by HGNC Official Full Name programmed cell death 6 interacting proteinprovided by HGNC Primary source HGNC:HGNC:8766 See related Ensembl:ENSG00000170248 MIM:608074; AllianceGenome:HGNC:8766 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP1; ALIX; HP95; DRIP4; MCPH29 Summary This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in colon (RPKM 28.2), esophagus (RPKM 23.0) and 25 other tissues See more Orthologs mouse all