TIAM2, Official Symbol TIAM2provided by HGNC Official Full Name TIAM Rac1 associated GEF 2provided by HGNC Primary source HGNC:HGNC:11806 See related Ensembl:ENSG00000146426 MIM:604709; AllianceGenome:HGNC:11806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STEF; TIAM-2 Summary This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 5.7), brain (RPKM 4.1) and 18 other tissues See more Orthologs mouse all