DDR2, Official Symbol DDR2provided by HGNC Official Full Name discoidin domain receptor tyrosine kinase 2provided by HGNC Primary source HGNC:HGNC:2731 See related Ensembl:ENSG00000162733 MIM:191311; AllianceGenome:HGNC:2731 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TKT; WRCN; MIG20a; NTRKR3; TYRO10 Summary This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017] Expression Broad expression in fat (RPKM 30.2), adrenal (RPKM 24.5) and 20 other tissues See more Orthologs mouse all