IRAK4, Official Symbol IRAK4provided by HGNC Official Full Name interleukin 1 receptor associated kinase 4provided by HGNC Primary source HGNC:HGNC:17967 See related Ensembl:ENSG00000198001 MIM:606883; AllianceGenome:HGNC:17967 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPD1; IMD67; REN64; IRAK-4; NY-REN-64 Summary This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in lymph node (RPKM 7.4), appendix (RPKM 6.9) and 25 other tissues See more Orthologs mouse all