MUC2, Official Symbol MUC2provided by HGNC Official Full Name mucin 2, oligomeric mucus/gel-formingprovided by HGNC Primary source HGNC:HGNC:7512 See related Ensembl:ENSG00000198788 MIM:158370; AllianceGenome:HGNC:7512 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLP; SMUC; MUC-2 Summary This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016] Annotation information Annotation category: suggests misassembly Expression Biased expression in colon (RPKM 65.6), small intestine (RPKM 19.0) and 2 other tissues See more Orthologs mouse all