MICA, Official Symbol MICAprovided by HGNC Official Full Name MHC class I polypeptide-related sequence Aprovided by HGNC Primary source HGNC:HGNC:7090 See related Ensembl:ENSG00000204520 IMGT/GENE-DB:MICA; MIM:600169; AllianceGenome:HGNC:7090 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIC-A; PERB11.1 Summary This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in lung (RPKM 8.7), endometrium (RPKM 7.4) and 25 other tissues See more Orthologs all