CDT1, Official Symbol CDT1provided by HGNC Official Full Name chromatin licensing and DNA replication factor 1provided by HGNC Primary source HGNC:HGNC:24576 See related Ensembl:ENSG00000167513 MIM:605525; AllianceGenome:HGNC:24576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUP; RIS2 Summary The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011] Expression Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues See more Orthologs mouse all