FUCA2, Official Symbol FUCA2provided by HGNC Official Full Name alpha-L-fucosidase 2provided by HGNC Primary source HGNC:HGNC:4008 See related Ensembl:ENSG00000001036 MIM:136820; AllianceGenome:HGNC:4008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ20N2.5 Summary This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in placenta (RPKM 24.8), colon (RPKM 24.3) and 25 other tissues See more Orthologs mouse all