CSGALNACT1, Official Symbol CSGALNACT1provided by HGNC Official Full Name chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by HGNC Primary source HGNC:HGNC:24290 See related Ensembl:ENSG00000147408 MIM:616615; AllianceGenome:HGNC:24290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ChGn; ChGn-1; SDJLABA; CSGalNAcT-1; beta4GalNAcT Summary This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017] Expression Broad expression in thyroid (RPKM 21.6), prostate (RPKM 12.2) and 17 other tissues See more Orthologs mouse all