APBA1, Official Symbol APBA1provided by HGNC Official Full Name amyloid beta precursor protein binding family A member 1provided by HGNC Primary source HGNC:HGNC:578 See related Ensembl:ENSG00000107282 MIM:602414; AllianceGenome:HGNC:578 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA Summary The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 13.2), spleen (RPKM 2.4) and 17 other tissues See more Orthologs mouse all