ZC3HC1, Official Symbol ZC3HC1provided by HGNC Official Full Name zinc finger C3HC-type containing 1provided by HGNC Primary source HGNC:HGNC:29913 See related Ensembl:ENSG00000091732 MIM:619746; AllianceGenome:HGNC:29913 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIPA; HSPC216 Summary This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 2.0) and 25 other tissues See more Orthologs mouse all