NQO1, Official Symbol NQO1provided by HGNC Official Full Name NAD(P)H quinone dehydrogenase 1provided by HGNC Primary source HGNC:HGNC:2874 See related Ensembl:ENSG00000181019 MIM:125860; AllianceGenome:HGNC:2874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DTD; QR1; DHQU; DIA4; NMOR1; NMORI Summary This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in stomach (RPKM 136.7), gall bladder (RPKM 67.3) and 11 other tissues See more Orthologs mouse all