WWP1, Official Symbol WWP1provided by HGNC Official Full Name WW domain containing E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:17004 See related Ensembl:ENSG00000123124 MIM:602307; AllianceGenome:HGNC:17004 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP5; Tiul1; hSDRP1 Summary WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more Orthologs mouse all