KCTD17, Official Symbol KCTD17provided by HGNC Official Full Name potassium channel tetramerization domain containing 17provided by HGNC Primary source HGNC:HGNC:25705 See related Ensembl:ENSG00000100379 MIM:616386; AllianceGenome:HGNC:25705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016] Expression Broad expression in brain (RPKM 11.5), testis (RPKM 10.6) and 22 other tissues See more Orthologs mouse all