GNAI1, Official Symbol GNAI1provided by HGNC Official Full Name G protein subunit alpha i1provided by HGNC Primary source HGNC:HGNC:4384 See related Ensembl:ENSG00000127955 MIM:139310; AllianceGenome:HGNC:4384 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gi; HG1B; NEDHISB Summary Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues See more Orthologs mouse all