COL8A2, Official Symbol COL8A2provided by HGNC Official Full Name collagen type VIII alpha 2 chainprovided by HGNC Primary source HGNC:HGNC:2216 See related Ensembl:ENSG00000171812 MIM:120252; AllianceGenome:HGNC:2216 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FECD; PPCD; FECD1; PPCD2 Summary This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Broad expression in placenta (RPKM 6.6), spleen (RPKM 3.6) and 22 other tissues See more Orthologs mouse all