STAT4, Official Symbol STAT4provided by HGNC Official Full Name signal transducer and activator of transcription 4provided by HGNC Primary source HGNC:HGNC:11365 See related Ensembl:ENSG00000138378 MIM:600558; AllianceGenome:HGNC:11365 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPMC; SLEB11 Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 9.8), lymph node (RPKM 6.0) and 17 other tissues See more Orthologs mouse all