APBA2, Official Symbol APBA2provided by HGNC Official Full Name amyloid beta precursor protein binding family A member 2provided by HGNC Primary source HGNC:HGNC:579 See related Ensembl:ENSG00000034053 MIM:602712; AllianceGenome:HGNC:579 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091 Summary The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017] Expression Biased expression in brain (RPKM 16.8), spleen (RPKM 2.5) and 4 other tissues See more Orthologs mouse all