CILP, Official Symbol CILPprovided by HGNC Official Full Name cartilage intermediate layer proteinprovided by HGNC Primary source HGNC:HGNC:1980 See related Ensembl:ENSG00000138615 MIM:603489; AllianceGenome:HGNC:1980 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CILP1; CILP-1; HsT18872 Summary Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010] Expression Biased expression in gall bladder (RPKM 29.3), fat (RPKM 19.1) and 12 other tissues See more Orthologs mouse all