SDCBP2, Official Symbol SDCBP2provided by HGNC Official Full Name syndecan binding protein 2provided by HGNC Primary source HGNC:HGNC:15756 See related Ensembl:ENSG00000125775 MIM:617358; AllianceGenome:HGNC:15756 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ST2; ST-2; SITAC; SITAC18 Summary The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011] Expression Biased expression in duodenum (RPKM 54.3), small intestine (RPKM 53.5) and 8 other tissues See more Orthologs mouse all