FLT3, Official Symbol FLT3provided by HGNC Official Full Name fms related receptor tyrosine kinase 3provided by HGNC Primary source HGNC:HGNC:3765 See related Ensembl:ENSG00000122025 MIM:136351; AllianceGenome:HGNC:3765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLK2; STK1; CD135; FLK-2 Summary This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] Expression Broad expression in spleen (RPKM 4.2), lymph node (RPKM 3.7) and 16 other tissues See more Orthologs mouse all