KDM5B, Official Symbol KDM5Bprovided by HGNC Official Full Name lysine demethylase 5Bprovided by HGNC Primary source HGNC:HGNC:18039 See related Ensembl:ENSG00000117139 MIM:605393; AllianceGenome:HGNC:18039 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT31; PLU1; PUT1; MRT65; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A Summary This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] Expression Broad expression in testis (RPKM 55.0), skin (RPKM 8.8) and 18 other tissues See more Orthologs mouse all