BAP1, Official Symbol BAP1provided by HGNC Official Full Name BRCA1 associated protein 1provided by HGNC Primary source HGNC:HGNC:950 See related Ensembl:ENSG00000163930 MIM:603089; AllianceGenome:HGNC:950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBM2; UVM2; KURIS; TPDS1; UCHL2; hucep-6; HUCEP-13 Summary This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013] Expression Ubiquitous expression in testis (RPKM 47.8), skin (RPKM 26.6) and 25 other tissues See more Orthologs mouse all