THBD, Official Symbol THBDprovided by HGNC Official Full Name thrombomodulinprovided by HGNC Primary source HGNC:HGNC:11784 See related Ensembl:ENSG00000178726 MIM:188040; AllianceGenome:HGNC:11784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TM; THRM; AHUS6; BDCA3; CD141; BDCA-3; THPH12 Summary The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] Orthologs mouse all