EXO5, Official Symbol EXO5provided by HGNC Official Full Name exonuclease 5provided by HGNC Primary source HGNC:HGNC:26115 See related Ensembl:ENSG00000164002 MIM:618601; AllianceGenome:HGNC:26115 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEM1; Exo V; hExo5; C1orf176 Summary The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016] Expression Ubiquitous expression in lymph node (RPKM 2.5), appendix (RPKM 2.1) and 25 other tissues See more Orthologs mouse all