CDKN2D, Official Symbol CDKN2Dprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 2Dprovided by HGNC Primary source HGNC:HGNC:1790 See related Ensembl:ENSG00000129355 MIM:600927; AllianceGenome:HGNC:1790 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p19; INK4D; p19-INK4D Summary The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 80.4), brain (RPKM 18.7) and 5 other tissues See more Orthologs mouse all