RUBCNL, Official Symbol RUBCNLprovided by HGNC Official Full Name rubicon like autophagy enhancerprovided by HGNC Primary source HGNC:HGNC:20420 See related Ensembl:ENSG00000102445 MIM:620175; AllianceGenome:HGNC:20420 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PACER; C13orf18; KIAA0226L Summary This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017] Expression Biased expression in lymph node (RPKM 14.1), spleen (RPKM 8.4) and 13 other tissues See more Orthologs mouse all