LMAN1, Official Symbol LMAN1provided by HGNC Official Full Name lectin, mannose binding 1provided by HGNC Primary source HGNC:HGNC:6631 See related Ensembl:ENSG00000074695 MIM:601567; AllianceGenome:HGNC:6631 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MR60; gp58; F5F8D; FMFD1; MCFD1; ERGIC53; ERGIC-53 Summary The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in thyroid (RPKM 65.5), liver (RPKM 54.8) and 25 other tissues See more Orthologs mouse all