MUC5B, Official Symbol MUC5Bprovided by HGNC Official Full Name mucin 5B, oligomeric mucus/gel-formingprovided by HGNC Primary source HGNC:HGNC:7516 See related Ensembl:ENSG00000117983 MIM:600770; AllianceGenome:HGNC:7516 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MG1; MUC5; MUC9; MUC-5B Summary This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010] Expression Biased expression in gall bladder (RPKM 56.3), colon (RPKM 19.6) and 3 other tissues See more Orthologs mouse all