EIF2AK2, Official Symbol EIF2AK2provided by HGNC Official Full Name eukaryotic translation initiation factor 2 alpha kinase 2provided by HGNC Primary source HGNC:HGNC:9437 See related Ensembl:ENSG00000055332 MIM:176871; AllianceGenome:HGNC:9437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83 Summary The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in bone marrow (RPKM 8.7), brain (RPKM 6.4) and 25 other tissues See more Orthologs mouse all