PIP4K2A, Official Symbol PIP4K2Aprovided by HGNC Official Full Name phosphatidylinositol-5-phosphate 4-kinase type 2 alphaprovided by HGNC Primary source HGNC:HGNC:8997 See related Ensembl:ENSG00000150867 MIM:603140; AllianceGenome:HGNC:8997 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIPK; PI5P4KA; PIP5K2A; PIP5KIIA; PIP5KII-alpha Summary Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 41.4), lymph node (RPKM 29.9) and 23 other tissues See more Orthologs mouse all