IFIT5, Official Symbol IFIT5provided by HGNC Official Full Name interferon induced protein with tetratricopeptide repeats 5provided by HGNC Primary source HGNC:HGNC:13328 See related Ensembl:ENSG00000152778 MIM:616135; AllianceGenome:HGNC:13328 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P58; RI58; ISG58 Summary Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 7.8), lung (RPKM 7.7) and 25 other tissues See more Orthologs all