PPP1R13B, Official Symbol PPP1R13Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 13Bprovided by HGNC Primary source HGNC:HGNC:14950 See related Ensembl:ENSG00000088808 MIM:606455; AllianceGenome:HGNC:14950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p85; ASPP1; p53BP2-like Summary This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues See more Orthologs mouse all