LAMA3, Official Symbol LAMA3provided by HGNC Official Full Name laminin subunit alpha 3provided by HGNC Primary source HGNC:HGNC:6483 See related Ensembl:ENSG00000053747 MIM:600805; AllianceGenome:HGNC:6483 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E170; LOCS; BM600; JEB2A; JEB2B; JEB2C; LAMNA Summary The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Broad expression in lung (RPKM 10.8), stomach (RPKM 10.0) and 18 other tissues See more Orthologs mouse all