DAG1, Official Symbol DAG1provided by HGNC Official Full Name dystroglycan 1provided by HGNC Primary source HGNC:HGNC:2666 See related Ensembl:ENSG00000173402 MIM:128239; AllianceGenome:HGNC:2666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A3a; DAG; AGRNR; 156DAG; MDDGA9; MDDGC7; MDDGC9; LGMDR16 Summary This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in placenta (RPKM 41.6), heart (RPKM 23.5) and 24 other tissues See more Orthologs mouse all