EIF5B, Official Symbol EIF5Bprovided by HGNC Official Full Name eukaryotic translation initiation factor 5Bprovided by HGNC Primary source HGNC:HGNC:30793 See related Ensembl:ENSG00000158417 MIM:606086; AllianceGenome:HGNC:30793 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IF2 Summary Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 26.2), testis (RPKM 23.3) and 25 other tissues See more Orthologs mouse all