NLRC4, Official Symbol NLRC4provided by HGNC Official Full Name NLR family CARD domain containing 4provided by HGNC Primary source HGNC:HGNC:16412 See related Ensembl:ENSG00000091106 MIM:606831; AllianceGenome:HGNC:16412 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1 Summary This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] Expression Broad expression in appendix (RPKM 5.7), bone marrow (RPKM 3.2) and 17 other tissues See more Orthologs mouse all