DOCK4, Official Symbol DOCK4provided by HGNC Official Full Name dedicator of cytokinesis 4provided by HGNC Primary source HGNC:HGNC:19192 See related Ensembl:ENSG00000128512 MIM:607679; AllianceGenome:HGNC:19192 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 9.6), brain (RPKM 9.0) and 23 other tissues See more Orthologs mouse all