RNF128, Official Symbol RNF128provided by HGNC Official Full Name ring finger protein 128provided by HGNC Primary source HGNC:HGNC:21153 See related Ensembl:ENSG00000133135 MIM:300439; AllianceGenome:HGNC:21153 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRAIL Summary The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in small intestine (RPKM 27.8), liver (RPKM 27.8) and 15 other tissues See more Orthologs mouse all