SPA17, Official Symbol SPA17provided by HGNC Official Full Name sperm autoantigenic protein 17provided by HGNC Primary source HGNC:HGNC:11210 See related Ensembl:ENSG00000064199 MIM:608621; AllianceGenome:HGNC:11210 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT22; SP17; SP17-1 Summary This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009] Expression Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues See more Orthologs mouse all