MACIR, Official Symbol MACIRprovided by HGNC Official Full Name macrophage immunometabolism regulatorprovided by HGNC Primary source HGNC:HGNC:25052 See related Ensembl:ENSG00000181751 MIM:616608; AllianceGenome:HGNC:25052 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C5orf30 Summary This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any other human protein. [provided by RefSeq, Dec 2019] Expression Broad expression in colon (RPKM 11.1), brain (RPKM 10.1) and 23 other tissues See more Orthologs mouse all