POFUT1, Official Symbol POFUT1provided by HGNC Official Full Name protein O-fucosyltransferase 1provided by HGNC Primary source HGNC:HGNC:14988 See related Ensembl:ENSG00000101346 MIM:607491; AllianceGenome:HGNC:14988 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1 Summary This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 10.9), small intestine (RPKM 10.7) and 25 other tissues See more Orthologs mouse all