MS4A2, Official Symbol MS4A2provided by HGNC Official Full Name membrane spanning 4-domains A2provided by HGNC Primary source HGNC:HGNC:7316 See related Ensembl:ENSG00000149534 MIM:147138; AllianceGenome:HGNC:7316 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APY; IGEL; IGER; ATOPY; FCERI; IGHER; FCER1B Summary The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012] Expression Biased expression in lung (RPKM 8.1), gall bladder (RPKM 5.4) and 13 other tissues See more Orthologs mouse all