RABGEF1, Official Symbol RABGEF1provided by HGNC Official Full Name RAB guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:17676 See related Ensembl:ENSG00000154710 MIM:609700; AllianceGenome:HGNC:17676 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAP1; RABEX5; rabex-5 Summary RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in bone marrow (RPKM 17.2), testis (RPKM 15.3) and 25 other tissues See more Orthologs mouse all