PPP1R1B, Official Symbol PPP1R1Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 1Bprovided by HGNC Primary source HGNC:HGNC:9287 See related Ensembl:ENSG00000131771 MIM:604399; AllianceGenome:HGNC:9287 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DARPP32; DARPP-32 Summary This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Biased expression in colon (RPKM 51.4), salivary gland (RPKM 45.0) and 11 other tissues See more Orthologs mouse all