ISL1, Official Symbol ISL1provided by HGNC Official Full Name ISL LIM homeobox 1provided by HGNC Primary source HGNC:HGNC:6132 See related Ensembl:ENSG00000016082 MIM:600366; AllianceGenome:HGNC:6132 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Isl-1; ISLET1 Summary This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 3.8), stomach (RPKM 3.1) and 9 other tissues See more Orthologs mouse all