RNF34, Official Symbol RNF34provided by HGNC Official Full Name ring finger protein 34provided by HGNC Primary source HGNC:HGNC:17297 See related Ensembl:ENSG00000170633 MIM:608299; AllianceGenome:HGNC:17297 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RFI; RIF; RIFF; hRFI; CARP1; CARP-1 Summary The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 13.4) and 25 other tissues See more Orthologs mouse all