DCK, Official Symbol DCKprovided by HGNC Official Full Name deoxycytidine kinaseprovided by HGNC Primary source HGNC:HGNC:2704 See related Ensembl:ENSG00000156136 MIM:125450; AllianceGenome:HGNC:2704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 50.3), appendix (RPKM 23.2) and 22 other tissues See more Orthologs mouse all