MMP8, Official Symbol MMP8provided by HGNC Official Full Name matrix metallopeptidase 8provided by HGNC Primary source HGNC:HGNC:7175 See related Ensembl:ENSG00000118113 MIM:120355; AllianceGenome:HGNC:7175 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNC; CLG1; MMP-8; PMNL-CL Summary This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Restricted expression toward bone marrow (RPKM 202.1) See more Orthologs mouse all