LAT, Official Symbol LATprovided by HGNC Official Full Name linker for activation of T cellsprovided by HGNC Primary source HGNC:HGNC:18874 See related Ensembl:ENSG00000213658 MIM:602354; AllianceGenome:HGNC:18874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAT1; pp36; IMD52 Summary The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues See more Orthologs mouse all