SERPING1, Official Symbol SERPING1provided by HGNC Official Full Name serpin family G member 1provided by HGNC Primary source HGNC:HGNC:1228 See related Ensembl:ENSG00000149131 MIM:606860; AllianceGenome:HGNC:1228 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1IN; C1NH; HAE1; HAE2; C1INH Summary This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020] Expression Broad expression in liver (RPKM 710.5), gall bladder (RPKM 322.8) and 17 other tissues See more Orthologs mouse all