PLA2G10, Official Symbol PLA2G10provided by HGNC Official Full Name phospholipase A2 group Xprovided by HGNC Primary source HGNC:HGNC:9029 See related Ensembl:ENSG00000069764 MIM:603603; AllianceGenome:HGNC:9029 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPLA2; GXPLA2; GXSPLA2; sPLA2-X Summary This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015] Expression Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues See more Orthologs mouse all