PDHB, Official Symbol PDHBprovided by HGNC Official Full Name pyruvate dehydrogenase E1 subunit betaprovided by HGNC Primary source HGNC:HGNC:8808 See related Ensembl:ENSG00000168291 MIM:179060; AllianceGenome:HGNC:8808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDHBD; PHE1B; E1beta; PDHE1B; PDHE1-B Summary The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in heart (RPKM 60.3), kidney (RPKM 43.5) and 25 other tissues See more Orthologs mouse all