FKBP5, Official Symbol FKBP5provided by HGNC Official Full Name FKBP prolyl isomerase 5provided by HGNC Primary source HGNC:HGNC:3721 See related Ensembl:ENSG00000096060 MIM:602623; AllianceGenome:HGNC:3721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] Expression Broad expression in fat (RPKM 97.5), lymph node (RPKM 33.3) and 18 other tissues See more Orthologs mouse all