THEMIS, Official Symbol THEMISprovided by HGNC Official Full Name thymocyte selection associatedprovided by HGNC Primary source HGNC:HGNC:21569 See related Ensembl:ENSG00000172673 MIM:613607; AllianceGenome:HGNC:21569 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GASP; SPOT; TSEPA; THEMIS1; C6orf190; C6orf207 Summary This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Expression Biased expression in lymph node (RPKM 2.2), appendix (RPKM 1.1) and 12 other tissues See more Orthologs mouse all