SGPP2, Official Symbol SGPP2provided by HGNC Official Full Name sphingosine-1-phosphate phosphatase 2provided by HGNC Primary source HGNC:HGNC:19953 See related Ensembl:ENSG00000163082 MIM:612827; AllianceGenome:HGNC:19953 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPP2; SPPase2 Summary The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016] Expression Broad expression in thyroid (RPKM 13.7), esophagus (RPKM 12.0) and 18 other tissues See more Orthologs mouse all