SOX6, Official Symbol SOX6provided by HGNC Official Full Name SRY-box transcription factor 6provided by HGNC Primary source HGNC:HGNC:16421 See related Ensembl:ENSG00000110693 MIM:607257; AllianceGenome:HGNC:16421 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOXD; HSSOX6; TOLCAS Summary This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] Expression Broad expression in brain (RPKM 4.6), kidney (RPKM 4.5) and 23 other tissues See more Orthologs mouse all