ANGPT2, Official Symbol ANGPT2provided by HGNC Official Full Name angiopoietin 2provided by HGNC Primary source HGNC:HGNC:485 See related Ensembl:ENSG00000091879 MIM:601922; AllianceGenome:HGNC:485 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANG2; AGPT2; LMPHM10 Summary This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020] Expression Broad expression in placenta (RPKM 6.2), urinary bladder (RPKM 5.1) and 19 other tissues See more Orthologs mouse all