ALOX15B, Official Symbol ALOX15Bprovided by HGNC Official Full Name arachidonate 15-lipoxygenase type Bprovided by HGNC Primary source HGNC:HGNC:434 See related Ensembl:ENSG00000179593 MIM:603697; AllianceGenome:HGNC:434 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 15-LOX-2 Summary This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 42.3), esophagus (RPKM 13.5) and 2 other tissues See more Orthologs mouse all