NOS3, Official Symbol NOS3provided by HGNC Official Full Name nitric oxide synthase 3provided by HGNC Primary source HGNC:HGNC:7876 See related Ensembl:ENSG00000164867 MIM:163729; AllianceGenome:HGNC:7876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eNOS; ECNOS Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Biased expression in spleen (RPKM 28.4), placenta (RPKM 4.0) and 11 other tissues See more Orthologs mouse all