MYH8, Official Symbol MYH8provided by HGNC Official Full Name myosin heavy chain 8provided by HGNC Primary source HGNC:HGNC:7578 See related Ensembl:ENSG00000133020 MIM:160741; AllianceGenome:HGNC:7578 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA7; MyHC-pn; gtMHC-F; MyHC-peri Summary Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009] Expression Biased expression in esophagus (RPKM 10.4), prostate (RPKM 1.7) and 1 other tissue See more Orthologs mouse all