THEM4, Official Symbol THEM4provided by HGNC Official Full Name thioesterase superfamily member 4provided by HGNC Primary source HGNC:HGNC:17947 See related Ensembl:ENSG00000159445 MIM:606388; AllianceGenome:HGNC:17947 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTMP Summary Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 4.4), testis (RPKM 3.1) and 25 other tissues See more Orthologs mouse all