SELENOO, Official Symbol SELENOOprovided by HGNC Official Full Name selenoprotein Oprovided by HGNC Primary source HGNC:HGNC:30395 See related Ensembl:ENSG00000073169 MIM:607917; AllianceGenome:HGNC:30395 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SELO Summary This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in bone marrow (RPKM 10.3), liver (RPKM 10.3) and 25 other tissues See more Orthologs mouse all