AKR7L, Official Symbol AKR7Lprovided by HGNC Official Full Name aldo-keto reductase family 7 like (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:24056 See related Ensembl:ENSG00000211454 MIM:608478; AllianceGenome:HGNC:24056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AFAR3; AKR7A4; AFB1-AR3; AFB1-AR 3 Summary This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Biased expression in duodenum (RPKM 22.1), small intestine (RPKM 15.8) and 5 other tissues See more Orthologs all