CHAC2, Official Symbol CHAC2provided by HGNC Official Full Name ChaC glutathione specific gamma-glutamylcyclotransferase 2provided by HGNC Primary source HGNC:HGNC:32363 See related Ensembl:ENSG00000143942 MIM:617446; AllianceGenome:HGNC:32363 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCG1 Summary The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in duodenum (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues See more Orthologs mouse all