PLEKHF1, Official Symbol PLEKHF1provided by HGNC Official Full Name pleckstrin homology and FYVE domain containing 1provided by HGNC Primary source HGNC:HGNC:20764 See related Ensembl:ENSG00000166289 MIM:615200; AllianceGenome:HGNC:20764 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APPD; LAPF; PHAFIN1; ZFYVE15 Summary Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in lysosome. Colocalizes with endosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 4.0), spleen (RPKM 2.2) and 24 other tissues See more Orthologs mouse all