TOLLIP, Official Symbol TOLLIPprovided by HGNC Official Full Name toll interacting proteinprovided by HGNC Primary source HGNC:HGNC:16476 See related Ensembl:ENSG00000078902 MIM:606277; AllianceGenome:HGNC:16476 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-1RAcPIP Summary This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 17.9) and 25 other tissues See more Orthologs mouse all