IRF5, Official Symbol IRF5provided by HGNC Official Full Name interferon regulatory factor 5provided by HGNC Primary source HGNC:HGNC:6120 See related Ensembl:ENSG00000128604 MIM:607218; AllianceGenome:HGNC:6120 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLEB10 Summary This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016] Expression Broad expression in spleen (RPKM 8.6), lymph node (RPKM 6.5) and 25 other tissues See more Orthologs mouse all