CRB1, Official Symbol CRB1provided by HGNC Official Full Name crumbs cell polarity complex component 1provided by HGNC Primary source HGNC:HGNC:2343 See related Ensembl:ENSG00000134376 MIM:604210; AllianceGenome:HGNC:2343 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCA8; RP12; CRB1-A; CRB1-B; CRB1-C Summary This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012] Expression Biased expression in brain (RPKM 4.0) and testis (RPKM 1.3) See more Orthologs mouse all