CAPN5, Official Symbol CAPN5provided by HGNC Official Full Name calpain 5provided by HGNC Primary source HGNC:HGNC:1482 See related Ensembl:ENSG00000149260 MIM:602537; AllianceGenome:HGNC:1482 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VRNI; ADNIV; HTRA3; nCL-3 Summary Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 33.5), duodenum (RPKM 28.3) and 19 other tissues See more Orthologs mouse all