PLEK2, Official Symbol PLEK2provided by HGNC Official Full Name pleckstrin 2provided by HGNC Primary source HGNC:HGNC:19238 See related Ensembl:ENSG00000100558 MIM:608007; AllianceGenome:HGNC:19238 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015] Expression Broad expression in adrenal (RPKM 16.6), small intestine (RPKM 14.3) and 17 other tissues See more Orthologs mouse all