NFATC4, Official Symbol NFATC4provided by HGNC Official Full Name nuclear factor of activated T cells 4provided by HGNC Primary source HGNC:HGNC:7778 See related Ensembl:ENSG00000100968 MIM:602699; AllianceGenome:HGNC:7778 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NFAT3; NF-AT3; NF-ATC4 Summary This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Broad expression in ovary (RPKM 15.2), endometrium (RPKM 13.8) and 22 other tissues See more Orthologs mouse all