IRGM, Official Symbol IRGMprovided by HGNC Official Full Name immunity related GTPase Mprovided by HGNC Primary source HGNC:HGNC:29597 See related Ensembl:ENSG00000237693 MIM:608212; AllianceGenome:HGNC:29597 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFI1; IBD19; IRGM1; LRG47; LRG-47 Summary This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016] Expression Low expression observed in reference dataset See more Orthologs all