GLRX3, Official Symbol GLRX3provided by HGNC Official Full Name glutaredoxin 3provided by HGNC Primary source HGNC:HGNC:15987 See related Ensembl:ENSG00000108010 MIM:612754; AllianceGenome:HGNC:15987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3 Summary This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues See more Orthologs mouse all