TDO2, Official Symbol TDO2provided by HGNC Official Full Name tryptophan 2,3-dioxygenaseprovided by HGNC Primary source HGNC:HGNC:11708 See related Ensembl:ENSG00000151790 MIM:191070; AllianceGenome:HGNC:11708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TO; TDO; TPH2; TRPO; HYPTRP Summary This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012] Expression Biased expression in liver (RPKM 202.8) and appendix (RPKM 14.2) See more Orthologs mouse all