NFE2, Official Symbol NFE2provided by HGNC Official Full Name nuclear factor, erythroid 2provided by HGNC Primary source HGNC:HGNC:7780 See related Ensembl:ENSG00000123405 MIM:601490; AllianceGenome:HGNC:7780 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p45; NF-E2 Summary Enables several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Contributes to cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 31.8), spleen (RPKM 3.5) and 3 other tissues See more Orthologs mouse all