GSK3B, Official Symbol GSK3Bprovided by HGNC Official Full Name glycogen synthase kinase 3 betaprovided by HGNC Primary source HGNC:HGNC:4617 See related Ensembl:ENSG00000082701 MIM:605004; AllianceGenome:HGNC:4617 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in brain (RPKM 13.9), thyroid (RPKM 9.9) and 25 other tissues See more Orthologs mouse all