DCP1A, Official Symbol DCP1Aprovided by HGNC Official Full Name decapping mRNA 1Aprovided by HGNC Primary source HGNC:HGNC:18714 See related Ensembl:ENSG00000272886 MIM:607010; AllianceGenome:HGNC:18714 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMIF; SMAD4IP1; HSA275986; Nbla00360 Summary Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in bone marrow (RPKM 10.4), ovary (RPKM 7.6) and 25 other tissues See more Orthologs mouse all