ARIH2, Official Symbol ARIH2provided by HGNC Official Full Name ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:690 See related Ensembl:ENSG00000177479 MIM:605615; AllianceGenome:HGNC:690 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARI2; TRIAD1 Summary The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues See more Orthologs mouse all