PKM, Official Symbol PKMprovided by HGNC Official Full Name pyruvate kinase M1/2provided by HGNC Primary source HGNC:HGNC:9021 See related Ensembl:ENSG00000067225 MIM:179050; AllianceGenome:HGNC:9021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PK3; TCB; p58; OIP3; PKM2; CTHBP; THBP1; HEL-S-30 Summary This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] Expression Ubiquitous expression in brain (RPKM 155.4), esophagus (RPKM 151.3) and 24 other tissues See more Orthologs mouse all