PROZ, Official Symbol PROZprovided by HGNC Official Full Name protein Z, vitamin K dependent plasma glycoproteinprovided by HGNC Primary source HGNC:HGNC:9460 See related Ensembl:ENSG00000126231 MIM:176895; AllianceGenome:HGNC:9460 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PZ Summary This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Biased expression in liver (RPKM 5.4), kidney (RPKM 4.0) and 1 other tissue See more Orthologs mouse all