SUFU, Official Symbol SUFUprovided by HGNC Official Full Name SUFU negative regulator of hedgehog signalingprovided by HGNC Primary source HGNC:HGNC:16466 See related Ensembl:ENSG00000107882 MIM:607035; AllianceGenome:HGNC:16466 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCNS2; SUFUH; JBTS32; SUFUXL; PRO1280 Summary The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Expression Ubiquitous expression in skin (RPKM 4.8), ovary (RPKM 4.2) and 25 other tissues See more Orthologs mouse all