KRT81, Official Symbol KRT81provided by HGNC Official Full Name keratin 81provided by HGNC Primary source HGNC:HGNC:6458 See related Ensembl:ENSG00000205426 MIM:602153; AllianceGenome:HGNC:6458 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HB1; K81; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1 Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 1.1), salivary gland (RPKM 0.5) and 13 other tissues See more Orthologs all