KIRREL2, Official Symbol KIRREL2provided by HGNC Official Full Name kirre like nephrin family adhesion molecule 2provided by HGNC Primary source HGNC:HGNC:18816 See related Ensembl:ENSG00000126259 MIM:607762; AllianceGenome:HGNC:18816 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NLG1; NEPH3; FILTRIN Summary This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016] Expression Biased expression in pancreas (RPKM 5.8), kidney (RPKM 0.6) and 3 other tissues See more Orthologs mouse all