GRIK3, Official Symbol GRIK3provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 3provided by HGNC Primary source HGNC:HGNC:4581 See related Ensembl:ENSG00000163873 MIM:138243; AllianceGenome:HGNC:4581 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAA5; GLR7; GLUR7; GluK3; GluR7a Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues See more Orthologs mouse all