RHOA, Official Symbol RHOAprovided by HGNC Official Full Name ras homolog family member Aprovided by HGNC Primary source HGNC:HGNC:667 See related Ensembl:ENSG00000067560 MIM:165390; AllianceGenome:HGNC:667 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHA; ARH12; RHO12; EDFAOB; RHOH12 Summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in fat (RPKM 218.4), lung (RPKM 210.7) and 25 other tissues See more Orthologs mouse all