FNDC5, Official Symbol FNDC5provided by HGNC Official Full Name fibronectin type III domain containing 5provided by HGNC Primary source HGNC:HGNC:20240 See related Ensembl:ENSG00000160097 MIM:611906; AllianceGenome:HGNC:20240 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRCP2; irisin Summary This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Biased expression in heart (RPKM 13.5), liver (RPKM 8.6) and 10 other tissues See more Orthologs mouse all