PCBP4, Official Symbol PCBP4provided by HGNC Official Full Name poly(rC) binding protein 4provided by HGNC Primary source HGNC:HGNC:8652 See related Ensembl:ENSG00000090097 MIM:608503; AllianceGenome:HGNC:8652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBP; LIP4; MCG10 Summary This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 22.5), prostate (RPKM 9.4) and 24 other tissues See more Orthologs mouse all