S100A4, Official Symbol S100A4provided by HGNC Official Full Name S100 calcium binding protein A4provided by HGNC Primary source HGNC:HGNC:10494 See related Ensembl:ENSG00000196154 MIM:114210; AllianceGenome:HGNC:10494 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98 Summary The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 268.4), bone marrow (RPKM 235.9) and 21 other tissues See more Orthologs mouse all