KLF1, Official Symbol KLF1provided by HGNC Official Full Name KLF transcription factor 1provided by HGNC Primary source HGNC:HGNC:6345 See related Ensembl:ENSG00000105610 MIM:600599; AllianceGenome:HGNC:6345 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EKLF; EKLF/KLF1 Summary This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009] Expression Restricted expression toward bone marrow (RPKM 14.0) See more Orthologs mouse all