TLE6, Official Symbol TLE6provided by HGNC Official Full Name TLE family member 6, subcortical maternal complex memberprovided by HGNC Primary source HGNC:HGNC:30788 See related Ensembl:ENSG00000104953 MIM:612399; AllianceGenome:HGNC:30788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRG6; PREMBL; OZEMA15 Summary This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Broad expression in thyroid (RPKM 2.5), placenta (RPKM 2.5) and 21 other tissues See more Orthologs mouse all