CHTF8, Official Symbol CHTF8provided by HGNC Official Full Name chromosome transmission fidelity factor 8provided by HGNC Primary source HGNC:HGNC:24353 See related Ensembl:ENSG00000168802 MIM:613202; AllianceGenome:HGNC:24353 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTF8; DERPC Summary This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Oct 2018] Expression Ubiquitous expression in thyroid (RPKM 29.7), kidney (RPKM 27.6) and 25 other tissues See more Orthologs mouse all