PCM1, Official Symbol PCM1provided by HGNC Official Full Name pericentriolar material 1provided by HGNC Primary source HGNC:HGNC:8727 See related Ensembl:ENSG00000078674 MIM:600299; AllianceGenome:HGNC:8727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTC4; RET/PCM-1 Summary The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues See more Orthologs mouse all