SPTSSB, Official Symbol SPTSSBprovided by HGNC Official Full Name serine palmitoyltransferase small subunit Bprovided by HGNC Primary source HGNC:HGNC:24045 See related Ensembl:ENSG00000196542 MIM:610412; AllianceGenome:HGNC:24045 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADMP; SSSPTB; C3orf57 Summary Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010] Expression Biased expression in stomach (RPKM 17.1), skin (RPKM 13.9) and 5 other tissues See more Orthologs mouse all