CERS1, Official Symbol CERS1provided by HGNC Official Full Name ceramide synthase 1provided by HGNC Primary source HGNC:HGNC:14253 See related Ensembl:ENSG00000223802 MIM:606919; AllianceGenome:HGNC:14253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPM8; GDF1; LAG1; UOG1; GDF-1; LASS1 Summary This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016] Expression Biased expression in brain (RPKM 22.5) and testis (RPKM 5.1) See more Orthologs mouse all