GNG5, Official Symbol GNG5provided by HGNC Official Full Name G protein subunit gamma 5provided by HGNC Primary source HGNC:HGNC:4408 See related Ensembl:ENSG00000174021 MIM:600874; AllianceGenome:HGNC:4408 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues See more Orthologs mouse all