TM4SF20, Official Symbol TM4SF20provided by HGNC Official Full Name transmembrane 4 L six family member 20provided by HGNC Primary source HGNC:HGNC:26230 See related Ensembl:ENSG00000168955 MIM:615404; AllianceGenome:HGNC:26230 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLI5; PRO994; TCCE518 Summary The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016] Expression Biased expression in duodenum (RPKM 117.7) and small intestine (RPKM 65.0) See more Orthologs mouse all