HAO1, Official Symbol HAO1provided by HGNC Official Full Name hydroxyacid oxidase 1provided by HGNC Primary source HGNC:HGNC:4809 See related Ensembl:ENSG00000101323 MIM:605023; AllianceGenome:HGNC:4809 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GO; GOX; GOX1; HAOX1 Summary This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 144.8) See more Orthologs mouse all