ING3, Official Symbol ING3provided by HGNC Official Full Name inhibitor of growth family member 3provided by HGNC Primary source HGNC:HGNC:14587 See related Ensembl:ENSG00000071243 MIM:607493; AllianceGenome:HGNC:14587 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Eaf4; ING2; MEAF4; p47ING3 Summary The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 18.3), lymph node (RPKM 6.0) and 24 other tissues See more Orthologs mouse all