EIF4G1, Official Symbol EIF4G1provided by HGNC Official Full Name eukaryotic translation initiation factor 4 gamma 1provided by HGNC Primary source HGNC:HGNC:3296 See related Ensembl:ENSG00000114867 MIM:600495; AllianceGenome:HGNC:3296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1 Summary The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues See more Orthologs mouse all