CRY2, Official Symbol CRY2provided by HGNC Official Full Name cryptochrome circadian regulator 2provided by HGNC Primary source HGNC:HGNC:2385 See related Ensembl:ENSG00000121671 MIM:603732; AllianceGenome:HGNC:2385 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCRY2; PHLL2 Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in heart (RPKM 24.1), brain (RPKM 22.3) and 25 other tissues See more Orthologs mouse all