XRCC5, Official Symbol XRCC5provided by HGNC Official Full Name X-ray repair cross complementing 5provided by HGNC Primary source HGNC:HGNC:12833 See related Ensembl:ENSG00000079246 MIM:194364; AllianceGenome:HGNC:12833 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KU80; KUB2; Ku86; NFIV; KARP1; KARP-1 Summary The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 87.8), lymph node (RPKM 70.4) and 25 other tissues See more Orthologs mouse all