HERC2, Official Symbol HERC2provided by HGNC Official Full Name HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:4868 See related Ensembl:ENSG00000128731 MIM:605837; AllianceGenome:HGNC:4868 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as jdf2; p528; MRT38; SHEP1; D15F37S1 Summary This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in brain (RPKM 8.9), ovary (RPKM 8.1) and 25 other tissues See more Orthologs mouse all