ANKH, Official Symbol ANKHprovided by HGNC Official Full Name ANKH inorganic pyrophosphate transport regulatorprovided by HGNC Primary source HGNC:HGNC:15492 See related Ensembl:ENSG00000154122 MIM:605145; AllianceGenome:HGNC:15492 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANK; CMDJ; HANK; MANK; CCAL2; CPPDD; SLC62A1 Summary This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 21.9), brain (RPKM 17.0) and 25 other tissues See more Orthologs mouse all