DYNLT1, Official Symbol DYNLT1provided by HGNC Official Full Name dynein light chain Tctex-type 1provided by HGNC Primary source HGNC:HGNC:11697 See related Ensembl:ENSG00000146425 MIM:601554; AllianceGenome:HGNC:11697 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CW-1; TCTEL1; TCTEX1; tctex-1 Summary This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues See more Orthologs all