RSPO3, Official Symbol RSPO3provided by HGNC Official Full Name R-spondin 3provided by HGNC Primary source HGNC:HGNC:20866 See related Ensembl:ENSG00000146374 MIM:610574; AllianceGenome:HGNC:20866 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PWTSR; THSD2; CRISTIN1 Summary This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013] Expression Broad expression in endometrium (RPKM 18.7), placenta (RPKM 8.3) and 14 other tissues See more Orthologs mouse all