ASIC3, Official Symbol ASIC3provided by HGNC Official Full Name acid sensing ion channel subunit 3provided by HGNC Primary source HGNC:HGNC:101 See related Ensembl:ENSG00000213199 MIM:611741; AllianceGenome:HGNC:101 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACCN3; TNaC1; DRASIC; SLNAC1 Summary This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] Expression Broad expression in testis (RPKM 3.0), brain (RPKM 2.0) and 20 other tissues See more Orthologs mouse all