CEP170, Official Symbol CEP170provided by HGNC Official Full Name centrosomal protein 170provided by HGNC Primary source HGNC:HGNC:28920 See related Ensembl:ENSG00000143702 MIM:613023; AllianceGenome:HGNC:28920 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAB; FAM68A; KIAA0470 Summary The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 12.9), testis (RPKM 11.4) and 23 other tissues See more Orthologs mouse all