APOC1, Official Symbol APOC1provided by HGNC Official Full Name apolipoprotein C1provided by HGNC Primary source HGNC:HGNC:607 See related Ensembl:ENSG00000130208 MIM:107710; AllianceGenome:HGNC:607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Apo-CI; ApoC-I; apo-CIB; apoC-IB Summary This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Biased expression in liver (RPKM 1936.2) and adrenal (RPKM 201.2) See more Orthologs mouse all