TMX4, Official Symbol TMX4provided by HGNC Official Full Name thioredoxin related transmembrane protein 4provided by HGNC Primary source HGNC:HGNC:25237 See related Ensembl:ENSG00000125827 MIM:616766; AllianceGenome:HGNC:25237 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDIA14; TXNDC13; DJ971N18.2 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017] Expression Broad expression in testis (RPKM 50.0), heart (RPKM 24.6) and 24 other tissues See more Orthologs mouse all