P2RX3, Official Symbol P2RX3provided by HGNC Official Full Name purinergic receptor P2X 3provided by HGNC Primary source HGNC:HGNC:8534 See related Ensembl:ENSG00000109991 MIM:600843; AllianceGenome:HGNC:8534 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X3 Summary This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017] Expression Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues See more Orthologs mouse all