SIGLEC1, Official Symbol SIGLEC1provided by HGNC Official Full Name sialic acid binding Ig like lectin 1provided by HGNC Primary source HGNC:HGNC:11127 See related Ensembl:ENSG00000088827 MIM:600751; AllianceGenome:HGNC:11127 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SN; CD169; SIGLEC-1 Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Broad expression in placenta (RPKM 8.2), spleen (RPKM 6.4) and 20 other tissues See more Orthologs mouse all