ETS1, Official Symbol ETS1provided by HGNC Official Full Name ETS proto-oncogene 1, transcription factorprovided by HGNC Primary source HGNC:HGNC:3488 See related Ensembl:ENSG00000134954 MIM:164720; AllianceGenome:HGNC:3488 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p54; ETS-1; EWSR2; c-ets-1 Summary This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Expression Broad expression in lymph node (RPKM 31.2), spleen (RPKM 21.4) and 22 other tissues See more Orthologs mouse all