ASXL3, Official Symbol ASXL3provided by HGNC Official Full Name ASXL transcriptional regulator 3provided by HGNC Primary source HGNC:HGNC:29357 See related Ensembl:ENSG00000141431 MIM:615115; AllianceGenome:HGNC:29357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRPS; KIAA1713 Summary This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017] Expression Biased expression in testis (RPKM 1.6), ovary (RPKM 1.3) and 12 other tissues See more Orthologs mouse all