SDHA, Official Symbol SDHAprovided by HGNC Official Full Name succinate dehydrogenase complex flavoprotein subunit Aprovided by HGNC Primary source HGNC:HGNC:10680 See related Ensembl:ENSG00000073578 MIM:600857; AllianceGenome:HGNC:10680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FP; PGL5; SDH1; SDH2; SDHF; CMD1GG; MC2DN1; NDAXOA Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] Expression Ubiquitous expression in heart (RPKM 63.7), kidney (RPKM 34.3) and 24 other tissues See more Orthologs mouse all