ARHGEF7, Official Symbol ARHGEF7provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 7provided by HGNC Primary source HGNC:HGNC:15607 See related Ensembl:ENSG00000102606 MIM:605477; AllianceGenome:HGNC:15607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314 Summary This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in brain (RPKM 14.7), fat (RPKM 11.2) and 25 other tissues See more Orthologs mouse all