ITPKA, Official Symbol ITPKAprovided by HGNC Official Full Name inositol-trisphosphate 3-kinase Aprovided by HGNC Primary source HGNC:HGNC:6178 See related Ensembl:ENSG00000137825 MIM:147521; AllianceGenome:HGNC:6178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IP3KA; IP3-3KA Summary Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011] Expression Biased expression in brain (RPKM 9.4), duodenum (RPKM 6.8) and 5 other tissues See more Orthologs mouse all