TNFSF14, Official Symbol TNFSF14provided by HGNC Official Full Name TNF superfamily member 14provided by HGNC Primary source HGNC:HGNC:11930 See related Ensembl:ENSG00000125735 MIM:604520; AllianceGenome:HGNC:11930 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LTg; CD258; HVEML; LIGHT Summary The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 1.5), appendix (RPKM 0.9) and 18 other tissues See more Orthologs mouse all