PLAU, Official Symbol PLAUprovided by HGNC Official Full Name plasminogen activator, urokinaseprovided by HGNC Primary source HGNC:HGNC:9052 See related Ensembl:ENSG00000122861 MIM:191840; AllianceGenome:HGNC:9052 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATF; QPD; UPA; URK; u-PA; BDPLT5 Summary This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Broad expression in appendix (RPKM 23.1), urinary bladder (RPKM 22.7) and 23 other tissues See more Orthologs mouse all