MADCAM1, Official Symbol MADCAM1provided by HGNC Official Full Name mucosal vascular addressin cell adhesion molecule 1provided by HGNC Primary source HGNC:HGNC:6765 See related Ensembl:ENSG00000099866 MIM:102670; AllianceGenome:HGNC:6765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MACAM1 Summary The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 6.2), spleen (RPKM 4.9) and 6 other tissues See more Orthologs mouse all