ASB2, Official Symbol ASB2provided by HGNC Official Full Name ankyrin repeat and SOCS box containing 2provided by HGNC Primary source HGNC:HGNC:16012 See related Ensembl:ENSG00000100628 MIM:605759; AllianceGenome:HGNC:16012 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASB-2 Summary This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Biased expression in heart (RPKM 15.5), prostate (RPKM 8.6) and 12 other tissues See more Orthologs mouse all