EIF2B4, Official Symbol EIF2B4provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit deltaprovided by HGNC Primary source HGNC:HGNC:3260 See related Ensembl:ENSG00000115211 MIM:606687; AllianceGenome:HGNC:3260 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM4; EIF2B; EIF-2B; EIF2Bdelta Summary Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 20.0), prostate (RPKM 13.7) and 25 other tissues See more Orthologs mouse all