THBS4, Official Symbol THBS4provided by HGNC Official Full Name thrombospondin 4provided by HGNC Primary source HGNC:HGNC:11788 See related Ensembl:ENSG00000113296 MIM:600715; AllianceGenome:HGNC:11788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSP4; TSP-4 Summary The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Biased expression in fat (RPKM 161.8), heart (RPKM 56.3) and 1 other tissue See more Orthologs mouse all