RORC, Official Symbol RORCprovided by HGNC Official Full Name RAR related orphan receptor Cprovided by HGNC Primary source HGNC:HGNC:10260 See related Ensembl:ENSG00000143365 MIM:602943; AllianceGenome:HGNC:10260 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA Summary The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 16.0), thyroid (RPKM 15.9) and 18 other tissues See more Orthologs mouse all