LACC1, Official Symbol LACC1provided by HGNC Official Full Name laccase domain containing 1provided by HGNC Primary source HGNC:HGNC:26789 See related Ensembl:ENSG00000179630 MIM:613409; AllianceGenome:HGNC:26789 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAMIN; JUVAR; C13orf31 Summary This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in testis (RPKM 5.5), small intestine (RPKM 5.3) and 25 other tissues See more Orthologs mouse all