MRPS6, Official Symbol MRPS6provided by HGNC Official Full Name mitochondrial ribosomal protein S6provided by HGNC Primary source HGNC:HGNC:14051 See related Ensembl:ENSG00000243927 MIM:611973; AllianceGenome:HGNC:14051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S6mt; bS6m; RPMS6; MRP-S6; C21orf101 Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 62.4), thyroid (RPKM 41.2) and 24 other tissues See more Orthologs mouse all