DNAH1, Official Symbol DNAH1provided by HGNC Official Full Name dynein axonemal heavy chain 1provided by HGNC Primary source HGNC:HGNC:2940 See related Ensembl:ENSG00000114841 MIM:603332; AllianceGenome:HGNC:2940 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HL11; HDHC7; HL-11; CILD37; DNAHC1; HSRF-1; SPGF18; XLHSRF-1 Summary This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017] Expression Broad expression in testis (RPKM 4.1), bone marrow (RPKM 2.9) and 25 other tissues See more Orthologs mouse all