TRDN, Official Symbol TRDNprovided by HGNC Official Full Name triadinprovided by HGNC Primary source HGNC:HGNC:12261 See related Ensembl:ENSG00000186439 MIM:603283; AllianceGenome:HGNC:12261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TDN; CPVT5; TRISK; CARDAR Summary This gene encodes an integral membrane protein found in skeletal and cardiac muscle. The encoded protein plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex and is required for normal skeletal muscle strength. This protein indirectly links triads and microtubules in skeletal muscle. Mutations in this gene are associated with cardiac arrythmia syndrome and some variants in this gene may be associated with sudden cardiac death. [provided by RefSeq, May 2022] Expression Biased expression in heart (RPKM 24.6), prostate (RPKM 6.0) and 2 other tissues See more Orthologs mouse all