YWHAZ, Official Symbol YWHAZprovided by HGNC Official Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaprovided by HGNC Primary source HGNC:HGNC:12855 See related Ensembl:ENSG00000164924 MIM:601288; AllianceGenome:HGNC:12855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEL4; YWHAD; KCIP-1; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in esophagus (RPKM 248.0), brain (RPKM 160.0) and 25 other tissues See more Orthologs mouse all