SPAG11B, Official Symbol SPAG11Bprovided by HGNC Official Full Name sperm associated antigen 11Bprovided by HGNC Primary source HGNC:HGNC:14534 See related Ensembl:ENSG00000164871 MIM:606560; AllianceGenome:HGNC:14534 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EP2; HE2; EP2C; EP2D; HE2C; EDDM2B; SPAG11; SPAG11A Summary This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all