BMP8A, Official Symbol BMP8Aprovided by HGNC Official Full Name bone morphogenetic protein 8aprovided by HGNC Primary source HGNC:HGNC:21650 See related Ensembl:ENSG00000183682 AllianceGenome:HGNC:21650 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Op2; OP-2 Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016] Expression Biased expression in thyroid (RPKM 57.4) and endometrium (RPKM 2.6) See more Orthologs mouse all