GRIK1, Official Symbol GRIK1provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 1provided by HGNC Primary source HGNC:HGNC:4579 See related Ensembl:ENSG00000171189 MIM:138245; AllianceGenome:HGNC:4579 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5 Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 3.8), brain (RPKM 1.9) and 2 other tissues See more Orthologs mouse all