MPO, Official Symbol MPOprovided by HGNC Official Full Name myeloperoxidaseprovided by HGNC Primary source HGNC:HGNC:7218 See related Ensembl:ENSG00000005381 MIM:606989; AllianceGenome:HGNC:7218 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] Expression Restricted expression toward bone marrow (RPKM 1596.3) See more Orthologs mouse all