RASGRP2, Official Symbol RASGRP2provided by HGNC Official Full Name RAS guanyl releasing protein 2provided by HGNC Primary source HGNC:HGNC:9879 See related Ensembl:ENSG00000068831 MIM:605577; AllianceGenome:HGNC:9879 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC25L; CALDAG-GEFI Summary The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Broad expression in bone marrow (RPKM 28.4), lymph node (RPKM 27.5) and 17 other tissues See more Orthologs mouse all