NCOA1, Official Symbol NCOA1provided by HGNC Official Full Name nuclear receptor coactivator 1provided by HGNC Primary source HGNC:HGNC:7668 See related Ensembl:ENSG00000084676 MIM:602691; AllianceGenome:HGNC:7668 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74 Summary The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues See more Orthologs mouse all