H3-3B, Official Symbol H3-3Bprovided by HGNC Official Full Name H3.3 histone Bprovided by HGNC Primary source HGNC:HGNC:4765 See related Ensembl:ENSG00000132475 MIM:601058; AllianceGenome:HGNC:4765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H3-3A; H3.3B; H3F3B; BRYLIB2 Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015] Expression Broad expression in bone marrow (RPKM 868.3), ovary (RPKM 358.6) and 24 other tissues See more Orthologs mouse all