TCF7L2, Official Symbol TCF7L2provided by HGNC Official Full Name transcription factor 7 like 2provided by HGNC Primary source HGNC:HGNC:11641 See related Ensembl:ENSG00000148737 MIM:602228; AllianceGenome:HGNC:11641 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCF4; TCF-4 Summary This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] Annotation information Note: TCF4 (Gene ID: 6925) and TCF7L2 (Gene ID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019] Expression Ubiquitous expression in fat (RPKM 12.8), colon (RPKM 11.3) and 25 other tissues See more Orthologs mouse all