MUC12, Official Symbol MUC12provided by HGNC Official Full Name mucin 12, cell surface associatedprovided by HGNC Primary source HGNC:HGNC:7510 See related Ensembl:ENSG00000205277 MIM:604609; AllianceGenome:HGNC:7510 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MUC11; MUC-11; MUC-12 Summary This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017] Expression Restricted expression toward colon (RPKM 48.0) See more Orthologs all