C5AR1, Official Symbol C5AR1provided by HGNC Official Full Name complement C5a receptor 1provided by HGNC Primary source HGNC:HGNC:1338 See related Ensembl:ENSG00000197405 MIM:113995; AllianceGenome:HGNC:1338 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C5A; C5AR; C5R1; CD88 Summary Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in appendix (RPKM 41.3), bone marrow (RPKM 38.2) and 11 other tissues See more Orthologs mouse all