TMPRSS3, Official Symbol TMPRSS3provided by HGNC Official Full Name transmembrane serine protease 3provided by HGNC Primary source HGNC:HGNC:11877 See related Ensembl:ENSG00000160183 MIM:605511; AllianceGenome:HGNC:11877 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB8; DFNB10; ECHOS1; TADG12 Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] Expression Biased expression in stomach (RPKM 9.6), gall bladder (RPKM 3.7) and 7 other tissues See more Orthologs mouse all