TFF1, Official Symbol TFF1provided by HGNC Official Full Name trefoil factor 1provided by HGNC Primary source HGNC:HGNC:11755 See related Ensembl:ENSG00000160182 MIM:113710; AllianceGenome:HGNC:11755 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21 Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward stomach (RPKM 2677.9) See more Orthologs mouse all