ME1, Official Symbol ME1provided by HGNC Official Full Name malic enzyme 1provided by HGNC Primary source HGNC:HGNC:6983 See related Ensembl:ENSG00000065833 MIM:154250; AllianceGenome:HGNC:6983 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MES; HUMNDME Summary This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues See more Orthologs mouse all