CMBL, Official Symbol CMBLprovided by HGNC Official Full Name carboxymethylenebutenolidase homologprovided by HGNC Primary source HGNC:HGNC:25090 See related Ensembl:ENSG00000164237 MIM:613379; AllianceGenome:HGNC:25090 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JS-1 Summary CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010] Expression Biased expression in kidney (RPKM 81.9), duodenum (RPKM 43.0) and 10 other tissues See more Orthologs mouse all