ATP6V1B2, Official Symbol ATP6V1B2provided by HGNC Official Full Name ATPase H+ transporting V1 subunit B2provided by HGNC Primary source HGNC:HGNC:854 See related Ensembl:ENSG00000147416 MIM:606939; AllianceGenome:HGNC:854 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOOD; HO57; VATB; VPP3; Vma2; ZLS2; ATP6B2; ATP6B1B2 Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 48.6), kidney (RPKM 28.3) and 24 other tissues See more Orthologs mouse all