CACNA2D4, Official Symbol CACNA2D4provided by HGNC Official Full Name calcium voltage-gated channel auxiliary subunit alpha2delta 4provided by HGNC Primary source HGNC:HGNC:20202 See related Ensembl:ENSG00000151062 MIM:608171; AllianceGenome:HGNC:20202 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCD4 Summary This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 1.1), appendix (RPKM 1.0) and 24 other tissues See more Orthologs mouse all