ADAMTS13, Official Symbol ADAMTS13provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 13provided by HGNC Primary source HGNC:HGNC:1366 See related Ensembl:ENSG00000160323 MIM:604134; AllianceGenome:HGNC:1366 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13 Summary This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Broad expression in liver (RPKM 4.0), testis (RPKM 2.7) and 24 other tissues See more Orthologs mouse all