PCK2, Official Symbol PCK2provided by HGNC Official Full Name phosphoenolpyruvate carboxykinase 2, mitochondrialprovided by HGNC Primary source HGNC:HGNC:8725 See related Ensembl:ENSG00000100889 MIM:614095; AllianceGenome:HGNC:8725 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEPCK; PEPCK2; PEPCK-M Summary This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] Expression Biased expression in duodenum (RPKM 127.7), small intestine (RPKM 91.2) and 8 other tissues See more Orthologs mouse all