MET, Official Symbol METprovided by HGNC Official Full Name MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:7029 See related Ensembl:ENSG00000105976 MIM:164860; AllianceGenome:HGNC:7029 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97 Summary This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] Expression Broad expression in placenta (RPKM 12.8), liver (RPKM 11.3) and 20 other tissues See more Orthologs mouse all