ROR1, Official Symbol ROR1provided by HGNC Official Full Name receptor tyrosine kinase like orphan receptor 1provided by HGNC Primary source HGNC:HGNC:10256 See related Ensembl:ENSG00000185483 MIM:602336; AllianceGenome:HGNC:10256 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTRKR1; dJ537F10.1 Summary This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues See more Orthologs mouse all