PPP2R1B, Official Symbol PPP2R1Bprovided by HGNC Official Full Name protein phosphatase 2 scaffold subunit Abetaprovided by HGNC Primary source HGNC:HGNC:9303 See related Ensembl:ENSG00000137713 MIM:603113; AllianceGenome:HGNC:9303 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PR65B; PP2A-Abeta Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] Expression Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues See more Orthologs mouse all