CYB5R2, Official Symbol CYB5R2provided by HGNC Official Full Name cytochrome b5 reductase 2provided by HGNC Primary source HGNC:HGNC:24376 See related Ensembl:ENSG00000166394 MIM:608342; AllianceGenome:HGNC:24376 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B5R.2 Summary The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Expression Biased expression in testis (RPKM 34.1), skin (RPKM 7.5) and 8 other tissues See more Orthologs mouse all