VCAN, Official Symbol VCANprovided by HGNC Official Full Name versicanprovided by HGNC Primary source HGNC:HGNC:2464 See related Ensembl:ENSG00000038427 MIM:118661; AllianceGenome:HGNC:2464 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WGN; ERVR; GHAP; PG-M; WGN1; CSPG2 Summary This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] Expression Broad expression in appendix (RPKM 45.0), placenta (RPKM 35.3) and 15 other tissues See more Orthologs mouse all