CHRD, Official Symbol CHRDprovided by HGNC Official Full Name chordinprovided by HGNC Primary source HGNC:HGNC:1949 See related Ensembl:ENSG00000090539 MIM:603475; AllianceGenome:HGNC:1949 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015] Expression Broad expression in endometrium (RPKM 10.5), liver (RPKM 6.4) and 23 other tissues See more Orthologs mouse all