IRS2, Official Symbol IRS2provided by HGNC Official Full Name insulin receptor substrate 2provided by HGNC Primary source HGNC:HGNC:6126 See related Ensembl:ENSG00000185950 MIM:600797; AllianceGenome:HGNC:6126 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRS-2 Summary This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 24.6), fat (RPKM 23.1) and 23 other tissues See more Orthologs mouse all