ARRDC3, Official Symbol ARRDC3provided by HGNC Official Full Name arrestin domain containing 3provided by HGNC Primary source HGNC:HGNC:29263 See related Ensembl:ENSG00000113369 MIM:612464; AllianceGenome:HGNC:29263 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLIMP Summary This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in bone marrow (RPKM 76.9), thyroid (RPKM 64.6) and 24 other tissues See more Orthologs mouse all