DTL, Official Symbol DTLprovided by HGNC Official Full Name denticleless E3 ubiquitin protein ligase homologprovided by HGNC Primary source HGNC:HGNC:30288 See related Ensembl:ENSG00000143476 MIM:610617; AllianceGenome:HGNC:30288 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDT2; RAMP; DCAF2; L2DTL Summary Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 9.8), bone marrow (RPKM 8.4) and 15 other tissues See more Orthologs mouse all