TDP1, Official Symbol TDP1provided by HGNC Official Full Name tyrosyl-DNA phosphodiesterase 1provided by HGNC Primary source HGNC:HGNC:18884 See related Ensembl:ENSG00000042088 MIM:607198; AllianceGenome:HGNC:18884 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016] Expression Broad expression in testis (RPKM 7.3), lymph node (RPKM 4.5) and 24 other tissues See more Orthologs mouse all