KATNB1, Official Symbol KATNB1provided by HGNC Official Full Name katanin regulatory subunit B1provided by HGNC Primary source HGNC:HGNC:6217 See related Ensembl:ENSG00000140854 MIM:602703; AllianceGenome:HGNC:6217 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAT; LIS6 Summary Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 14.6), brain (RPKM 7.5) and 24 other tissues See more Orthologs mouse all