ANTXR1, Official Symbol ANTXR1provided by HGNC Official Full Name ANTXR cell adhesion molecule 1provided by HGNC Primary source HGNC:HGNC:21014 See related Ensembl:ENSG00000169604 MIM:606410; AllianceGenome:HGNC:21014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATR; GAPO; TEM8 Summary This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] Expression Broad expression in gall bladder (RPKM 37.4), ovary (RPKM 30.6) and 21 other tissues See more Orthologs mouse all