SMG6, Official Symbol SMG6provided by HGNC Official Full Name SMG6 nonsense mediated mRNA decay factorprovided by HGNC Primary source HGNC:HGNC:17809 See related Ensembl:ENSG00000070366 MIM:610963; AllianceGenome:HGNC:17809 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EST1A; SMG-6; hEST1A; C17orf31; hSMG5/7a Summary This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in ovary (RPKM 7.3), testis (RPKM 5.9) and 25 other tissues See more Orthologs mouse all