FGFR4, Official Symbol FGFR4provided by HGNC Official Full Name fibroblast growth factor receptor 4provided by HGNC Primary source HGNC:HGNC:3691 See related Ensembl:ENSG00000160867 MIM:134935; AllianceGenome:HGNC:3691 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TKF; JTK2; CD334 Summary The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017] Expression Broad expression in lung (RPKM 16.7), kidney (RPKM 12.5) and 15 other tissues See more Orthologs mouse all