TRPM6, Official Symbol TRPM6provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 6provided by HGNC Primary source HGNC:HGNC:17995 See related Ensembl:ENSG00000119121 MIM:607009; AllianceGenome:HGNC:17995 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSH; HMGX; HOMG; CHAK2; HOMG1 Summary This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010] Expression Biased expression in colon (RPKM 8.1), small intestine (RPKM 3.5) and 5 other tissues See more Orthologs mouse all