TEK, Official Symbol TEKprovided by HGNC Official Full Name TEK receptor tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:11724 See related Ensembl:ENSG00000120156 MIM:600221; AllianceGenome:HGNC:11724 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B Summary This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] Expression Broad expression in lung (RPKM 19.9), placenta (RPKM 18.9) and 21 other tissues See more Orthologs mouse all