RGS17, Official Symbol RGS17provided by HGNC Official Full Name regulator of G protein signaling 17provided by HGNC Primary source HGNC:HGNC:14088 See related Ensembl:ENSG00000091844 MIM:607191; AllianceGenome:HGNC:14088 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGSZ2; RGS-17; hRGS17 Summary This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues See more Orthologs mouse all