PIK3C2G, Official Symbol PIK3C2Gprovided by HGNC Official Full Name phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaprovided by HGNC Primary source HGNC:HGNC:8973 See related Ensembl:ENSG00000139144 MIM:609001; AllianceGenome:HGNC:8973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PI3K-C2GAMMA; PI3K-C2-gamma Summary The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Biased expression in stomach (RPKM 3.1), skin (RPKM 2.0) and 7 other tissues See more Orthologs mouse all