CASP8AP2, Official Symbol CASP8AP2provided by HGNC Official Full Name caspase 8 associated protein 2provided by HGNC Primary source HGNC:HGNC:1510 See related Ensembl:ENSG00000118412 MIM:606880; AllianceGenome:HGNC:1510 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CED-4; FLASH; RIP25 Summary This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008] Annotation information Annotation category: suggests misassembly Annotation category: partial on reference assembly Expression Ubiquitous expression in lymph node (RPKM 5.6), testis (RPKM 4.6) and 25 other tissues See more Orthologs mouse all