ESPN, Official Symbol ESPNprovided by HGNC Official Full Name espinprovided by HGNC Primary source HGNC:HGNC:13281 See related Ensembl:ENSG00000187017 MIM:606351; AllianceGenome:HGNC:13281 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USH1M; DFNB36; LP2654 Summary This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009] Expression Biased expression in testis (RPKM 9.0), skin (RPKM 5.5) and 8 other tissues See more Orthologs mouse all