LIF, Official Symbol LIFprovided by HGNC Official Full Name LIF interleukin 6 family cytokineprovided by HGNC Primary source HGNC:HGNC:6596 See related Ensembl:ENSG00000128342 MIM:159540; AllianceGenome:HGNC:6596 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDF; DIA; HILDA; MLPLI Summary The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in gall bladder (RPKM 20.9), appendix (RPKM 11.6) and 16 other tissues See more Orthologs mouse all