TCF7L1, Official Symbol TCF7L1provided by HGNC Official Full Name transcription factor 7 like 1provided by HGNC Primary source HGNC:HGNC:11640 See related Ensembl:ENSG00000152284 MIM:604652; AllianceGenome:HGNC:11640 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCF3; TCF-3 Summary This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in fat (RPKM 14.2), ovary (RPKM 9.6) and 23 other tissues See more Orthologs mouse all