PRIM2, Official Symbol PRIM2provided by HGNC Official Full Name DNA primase subunit 2provided by HGNC Primary source HGNC:HGNC:9370 See related Ensembl:ENSG00000146143 MIM:176636; AllianceGenome:HGNC:9370 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p58; PRIM2A Summary This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014] Expression Broad expression in prostate (RPKM 6.3), lymph node (RPKM 1.3) and 21 other tissues See more Orthologs mouse all