NNT, Official Symbol NNTprovided by HGNC Official Full Name nicotinamide nucleotide transhydrogenaseprovided by HGNC Primary source HGNC:HGNC:7863 See related Ensembl:ENSG00000112992 MIM:607878; AllianceGenome:HGNC:7863 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCCD4 Summary This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016] Expression Broad expression in heart (RPKM 59.4), liver (RPKM 33.2) and 24 other tissues See more Orthologs mouse all