ARHGEF26, Official Symbol ARHGEF26provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 26provided by HGNC Primary source HGNC:HGNC:24490 See related Ensembl:ENSG00000114790 MIM:617552; AllianceGenome:HGNC:24490 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SGEF; CSGEF; HMFN1864 Summary This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] Expression Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues See more Orthologs mouse all