RGCC, Official Symbol RGCCprovided by HGNC Official Full Name regulator of cell cycleprovided by HGNC Primary source HGNC:HGNC:20369 See related Ensembl:ENSG00000102760 MIM:610077; AllianceGenome:HGNC:20369 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGC32; RGC-32; C13orf15; bA157L14.2 Summary This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 99.1), lung (RPKM 65.2) and 11 other tissues See more Orthologs mouse all