TONSL, Official Symbol TONSLprovided by HGNC Official Full Name tonsoku like, DNA repair proteinprovided by HGNC Primary source HGNC:HGNC:7801 See related Ensembl:ENSG00000160949 MIM:604546; AllianceGenome:HGNC:7801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKBR; SEMDSP; NFKBIL2 Summary The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 3.5), small intestine (RPKM 2.3) and 24 other tissues See more Orthologs mouse all