HOXB5, Official Symbol HOXB5provided by HGNC Official Full Name homeobox B5provided by HGNC Primary source HGNC:HGNC:5116 See related Ensembl:ENSG00000120075 MIM:142960; AllianceGenome:HGNC:5116 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX2; HU-1; HOX2A; Hox2.1; HHO.C10 Summary This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 6.1), colon (RPKM 5.0) and 13 other tissues See more Orthologs mouse all