CYP1B1, Official Symbol CYP1B1provided by HGNC Official Full Name cytochrome P450 family 1 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:2597 See related Ensembl:ENSG00000138061 MIM:601771; AllianceGenome:HGNC:2597 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP1B; ASGD6; GLC3A; CYPIB1; P4501B1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 32.6), endometrium (RPKM 26.2) and 19 other tissues See more Orthologs mouse all