XIST, Official Symbol XISTprovided by HGNC Official Full Name X inactive specific transcriptprovided by HGNC Primary source HGNC:HGNC:12810 See related Ensembl:ENSG00000229807 MIM:314670; AllianceGenome:HGNC:12810 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SXI1; swd66; DXS1089; DXS399E; LINC00001; NCRNA00001 Summary X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012] Expression Broad expression in thyroid (RPKM 59.4), ovary (RPKM 51.4) and 20 other tissues See more