PRKCA, Official Symbol PRKCAprovided by HGNC Official Full Name protein kinase C alphaprovided by HGNC Primary source HGNC:HGNC:9393 See related Ensembl:ENSG00000154229 MIM:176960; AllianceGenome:HGNC:9393 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 12.7), adrenal (RPKM 6.5) and 22 other tissues See more Orthologs mouse all