USP35, Official Symbol USP35provided by HGNC Official Full Name ubiquitin specific peptidase 35provided by HGNC Primary source HGNC:HGNC:20061 See related Ensembl:ENSG00000118369 AllianceGenome:HGNC:20061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in adrenal (RPKM 3.3), brain (RPKM 2.1) and 25 other tissues See more Orthologs mouse all