PIEZO2, Official Symbol PIEZO2provided by HGNC Official Full Name piezo type mechanosensitive ion channel component 2provided by HGNC Primary source HGNC:HGNC:26270 See related Ensembl:ENSG00000154864 MIM:613629; AllianceGenome:HGNC:26270 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA3; DA5; MWKS; DAIPT; FAM38B; HsT748; HsT771; FAM38B2; C18orf30; C18orf58 Summary The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] Expression Broad expression in lung (RPKM 2.7), gall bladder (RPKM 2.6) and 20 other tissues See more Orthologs mouse all