JAG1, Official Symbol JAG1provided by HGNC Official Full Name jagged canonical Notch ligand 1provided by HGNC Primary source HGNC:HGNC:6188 See related Ensembl:ENSG00000101384 MIM:601920; AllianceGenome:HGNC:6188 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS; AHD; AWS; HJ1; AGS1; DCHE; CD339; JAGL1; CMT2HH Summary The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019] Expression Ubiquitous expression in placenta (RPKM 27.7), skin (RPKM 22.8) and 24 other tissues See more Orthologs mouse all