RASD2, Official Symbol RASD2provided by HGNC Official Full Name RASD family member 2provided by HGNC Primary source HGNC:HGNC:18229 See related Ensembl:ENSG00000100302 MIM:612842; AllianceGenome:HGNC:18229 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Rhes; TEM2 Summary This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016] Expression Broad expression in prostate (RPKM 3.2), brain (RPKM 2.7) and 18 other tissues See more Orthologs mouse all