HTRA1, Official Symbol HTRA1provided by HGNC Official Full Name HtrA serine peptidase 1provided by HGNC Primary source HGNC:HGNC:9476 See related Ensembl:ENSG00000166033 MIM:602194; AllianceGenome:HGNC:9476 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L56; HtrA; ARMD7; ORF480; PRSS11; CARASIL; CADASIL2 Summary This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 155.6), gall bladder (RPKM 130.0) and 22 other tissues See more Orthologs mouse all