PUF60, Official Symbol PUF60provided by HGNC Official Full Name poly(U) binding splicing factor 60provided by HGNC Primary source HGNC:HGNC:17042 See related Ensembl:ENSG00000179950 MIM:604819; AllianceGenome:HGNC:17042 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIR; VRJS; RoBPI; SIAHBP1 Summary This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in brain (RPKM 18.5), testis (RPKM 17.6) and 25 other tissues See more Orthologs mouse all