GLI1, Official Symbol GLI1provided by HGNC Official Full Name GLI family zinc finger 1provided by HGNC Primary source HGNC:HGNC:4317 See related Ensembl:ENSG00000111087 MIM:165220; AllianceGenome:HGNC:4317 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLI; PPD1; PAPA8 Summary This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] Expression Broad expression in endometrium (RPKM 5.6), testis (RPKM 2.9) and 15 other tissues See more Orthologs mouse all