CD207, Official Symbol CD207provided by HGNC Official Full Name CD207 moleculeprovided by HGNC Primary source HGNC:HGNC:17935 See related Ensembl:ENSG00000116031 MIM:604862; AllianceGenome:HGNC:17935 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLEC4K Summary The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010] Expression Biased expression in skin (RPKM 26.1), esophagus (RPKM 6.2) and 1 other tissue See more Orthologs mouse all