CBX1, Official Symbol CBX1provided by HGNC Official Full Name chromobox 1provided by HGNC Primary source HGNC:HGNC:1551 See related Ensembl:ENSG00000108468 MIM:604511; AllianceGenome:HGNC:1551 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBX; M31; MOD1; Hp1beta; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta Summary This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 37.6), brain (RPKM 33.7) and 24 other tissues See more Orthologs mouse all