SPP1, Official Symbol SPP1provided by HGNC Official Full Name secreted phosphoprotein 1provided by HGNC Primary source HGNC:HGNC:11255 See related Ensembl:ENSG00000118785 MIM:166490; AllianceGenome:HGNC:11255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPN; BNSP; BSPI; ETA-1 Summary The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Biased expression in placenta (RPKM 1043.5), gall bladder (RPKM 1025.4) and 3 other tissues See more Orthologs mouse all