IQSEC2, Official Symbol IQSEC2provided by HGNC Official Full Name IQ motif and Sec7 domain ArfGEF 2provided by HGNC Primary source HGNC:HGNC:29059 See related Ensembl:ENSG00000124313 MIM:300522; AllianceGenome:HGNC:29059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRX1; BRAG1; MRX18; MRX78; XLID1; IQ-ArfGEF Summary This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in brain (RPKM 5.1), adrenal (RPKM 1.4) and 23 other tissues See more Orthologs mouse all