GRIA4, Official Symbol GRIA4provided by HGNC Official Full Name glutamate ionotropic receptor AMPA type subunit 4provided by HGNC Primary source HGNC:HGNC:4574 See related Ensembl:ENSG00000152578 MIM:138246; AllianceGenome:HGNC:4574 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLUR4; GLURD; GluA4; GLUR4C; NEDSGA; GluA4-ATD Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 8.8), adrenal (RPKM 0.9) and 1 other tissue See more Orthologs mouse all