EME1, Official Symbol EME1provided by HGNC Official Full Name essential meiotic structure-specific endonuclease 1provided by HGNC Primary source HGNC:HGNC:24965 See related Ensembl:ENSG00000154920 MIM:610885; AllianceGenome:HGNC:24965 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMS4L; SLX2A Summary This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] Expression Broad expression in testis (RPKM 5.3), bone marrow (RPKM 3.4) and 25 other tissues See more Orthologs mouse all