RNF217, Official Symbol RNF217provided by HGNC Official Full Name ring finger protein 217provided by HGNC Primary source HGNC:HGNC:21487 See related Ensembl:ENSG00000146373 MIM:618592; AllianceGenome:HGNC:21487 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSTL; IBRDC1; C6orf172; dJ84N20.1 Summary This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in fat (RPKM 3.1), skin (RPKM 2.9) and 25 other tissues See more Orthologs mouse all