CYP46A1, Official Symbol CYP46A1provided by HGNC Official Full Name cytochrome P450 family 46 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2641 See related Ensembl:ENSG00000036530 MIM:604087; AllianceGenome:HGNC:2641 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP46; CYP46 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 14.7), heart (RPKM 1.0) and 2 other tissues See more Orthologs mouse all