ASAH2, Official Symbol ASAH2provided by HGNC Official Full Name N-acylsphingosine amidohydrolase 2provided by HGNC Primary source HGNC:HGNC:18860 See related Ensembl:ENSG00000188611 MIM:611202; AllianceGenome:HGNC:18860 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNAC1; BCDase; LCDase; NCDase; N-CDase Summary Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008] Expression Biased expression in duodenum (RPKM 35.9), small intestine (RPKM 31.0) and 1 other tissue See more Orthologs mouse all