THG1L, Official Symbol THG1Lprovided by HGNC Official Full Name tRNA-histidine guanylyltransferase 1 likeprovided by HGNC Primary source HGNC:HGNC:26053 See related Ensembl:ENSG00000113272 MIM:618802; AllianceGenome:HGNC:26053 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IHG1; THG1; ICF45; IHG-1; hTHG1; SCAR28 Summary The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in thyroid (RPKM 4.1), colon (RPKM 3.8) and 25 other tissues See more Orthologs mouse all