ACTC1, Official Symbol ACTC1provided by HGNC Official Full Name actin alpha cardiac muscle 1provided by HGNC Primary source HGNC:HGNC:143 See related Ensembl:ENSG00000159251 MIM:102540; AllianceGenome:HGNC:143 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACTC; ASD5; CMD1R; CMH11; LVNC4 Summary Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008] Expression Restricted expression toward heart (RPKM 1532.4) See more Orthologs mouse all