PKNOX2, Official Symbol PKNOX2provided by HGNC Official Full Name PBX/knotted 1 homeobox 2provided by HGNC Primary source HGNC:HGNC:16714 See related Ensembl:ENSG00000165495 MIM:613066; AllianceGenome:HGNC:16714 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PREP2 Summary Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009] Expression Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues See more Orthologs mouse all