SPO11, Official Symbol SPO11provided by HGNC Official Full Name SPO11 initiator of meiotic double strand breaksprovided by HGNC Primary source HGNC:HGNC:11250 See related Ensembl:ENSG00000054796 MIM:605114; AllianceGenome:HGNC:11250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT35; TOPVIA; SPATA43; TOPOVIA Summary Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 4.0) See more Orthologs mouse all