XDH, Official Symbol XDHprovided by HGNC Official Full Name xanthine dehydrogenaseprovided by HGNC Primary source HGNC:HGNC:12805 See related Ensembl:ENSG00000158125 MIM:607633; AllianceGenome:HGNC:12805 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XO; XOR; XAN1 Summary Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014] Expression Biased expression in small intestine (RPKM 24.3), duodenum (RPKM 21.4) and 6 other tissues See more Orthologs mouse all