HCN4, Official Symbol HCN4provided by HGNC Official Full Name hyperpolarization activated cyclic nucleotide gated potassium channel 4provided by HGNC Primary source HGNC:HGNC:16882 See related Ensembl:ENSG00000138622 MIM:605206; AllianceGenome:HGNC:16882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSS2; EIG18; BRGDA8 Summary This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008] Expression Biased expression in testis (RPKM 3.3), heart (RPKM 1.0) and 3 other tissues See more Orthologs mouse all