ESR2, Official Symbol ESR2provided by HGNC Official Full Name estrogen receptor 2provided by HGNC Primary source HGNC:HGNC:3468 See related Ensembl:ENSG00000140009 MIM:601663; AllianceGenome:HGNC:3468 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Erb; ESRB; ODG8; ESTRB; NR3A2; ER-BETA; ESR-BETA Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 1.8), adrenal (RPKM 1.1) and 16 other tissues See more Orthologs mouse all