KCNIP4, Official Symbol KCNIP4provided by HGNC Official Full Name potassium voltage-gated channel interacting protein 4provided by HGNC Primary source HGNC:HGNC:30083 See related Ensembl:ENSG00000185774 MIM:608182; AllianceGenome:HGNC:30083 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CALP; KCHIP4 Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 3.7), endometrium (RPKM 1.2) and 15 other tissues See more Orthologs mouse all