UBE2M, Official Symbol UBE2Mprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Mprovided by HGNC Primary source HGNC:HGNC:12491 See related Ensembl:ENSG00000130725 MIM:603173; AllianceGenome:HGNC:12491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC12; hUbc12; UBC-RS2 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 24.7), testis (RPKM 23.2) and 25 other tissues See more Orthologs mouse all