PRR5, Official Symbol PRR5provided by HGNC Official Full Name proline rich 5provided by HGNC Primary source HGNC:HGNC:31682 See related Ensembl:ENSG00000186654 MIM:609406; AllianceGenome:HGNC:31682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP610; PROTOR1; PROTOR-1; FLJ20185k Summary This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010] Expression Broad expression in fat (RPKM 9.7), spleen (RPKM 8.6) and 23 other tissues See more Orthologs mouse all