RNF111, Official Symbol RNF111provided by HGNC Official Full Name ring finger protein 111provided by HGNC Primary source HGNC:HGNC:17384 See related Ensembl:ENSG00000157450 MIM:605840; AllianceGenome:HGNC:17384 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARK; hRNF111 Summary The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 5.8), brain (RPKM 5.5) and 25 other tissues See more Orthologs mouse all