MED13, Official Symbol MED13provided by HGNC Official Full Name mediator complex subunit 13provided by HGNC Primary source HGNC:HGNC:22474 See related Ensembl:ENSG00000108510 MIM:603808; AllianceGenome:HGNC:22474 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRD61; ARC250; THRAP1; DRIP250; HSPC221; TRAP240 Summary This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues See more Orthologs mouse all