ATP1A3, Official Symbol ATP1A3provided by HGNC Official Full Name ATPase Na+/K+ transporting subunit alpha 3provided by HGNC Primary source HGNC:HGNC:801 See related Ensembl:ENSG00000105409 MIM:182350; AllianceGenome:HGNC:801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDP; AHC2; CAPOS; DEE99; DYT12; ATP1A1 Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Biased expression in brain (RPKM 145.6), heart (RPKM 51.8) and 2 other tissues See more Orthologs mouse all