ITIH5, Official Symbol ITIH5provided by HGNC Official Full Name inter-alpha-trypsin inhibitor heavy chain 5provided by HGNC Primary source HGNC:HGNC:21449 See related Ensembl:ENSG00000123243 MIM:609783; AllianceGenome:HGNC:21449 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ITI-HC5; PP14776 Summary This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Broad expression in fat (RPKM 49.7), placenta (RPKM 32.8) and 18 other tissues See more Orthologs mouse all