SPPL3, Official Symbol SPPL3provided by HGNC Official Full Name signal peptide peptidase like 3provided by HGNC Primary source HGNC:HGNC:30424 See related Ensembl:ENSG00000157837 MIM:608240; AllianceGenome:HGNC:30424 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMP2; PSH1; PSL4; PRO4332; MDHV1887 Summary Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Located in Golgi-associated vesicle membrane; plasma membrane; and rough endoplasmic reticulum. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 21.6), testis (RPKM 17.3) and 25 other tissues See more Orthologs mouse all