MAN2A1, Official Symbol MAN2A1provided by HGNC Official Full Name mannosidase alpha class 2A member 1provided by HGNC Primary source HGNC:HGNC:6824 See related Ensembl:ENSG00000112893 MIM:154582; AllianceGenome:HGNC:6824 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MANA2; MANII; GOLIM7; AMan II Summary This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013] Expression Ubiquitous expression in duodenum (RPKM 14.9), colon (RPKM 14.2) and 25 other tissues See more Orthologs mouse all