DEGS1, Official Symbol DEGS1provided by HGNC Official Full Name delta 4-desaturase, sphingolipid 1provided by HGNC Primary source HGNC:HGNC:13709 See related Ensembl:ENSG00000143753 MIM:615843; AllianceGenome:HGNC:13709 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLD; DEGS; DES1; Des-1; FADS7; HLD18; MIG15; DEGS-1 Summary This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010] Expression Broad expression in skin (RPKM 186.9), placenta (RPKM 50.2) and 21 other tissues See more Orthologs mouse all