PRLR, Official Symbol PRLRprovided by HGNC Official Full Name prolactin receptorprovided by HGNC Primary source HGNC:HGNC:9446 See related Ensembl:ENSG00000113494 MIM:176761; AllianceGenome:HGNC:9446 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPRL; MFAB; hPRLrI; RI-PRLR Summary This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] Expression Biased expression in placenta (RPKM 18.9), endometrium (RPKM 11.6) and 8 other tissues See more Orthologs mouse all