IL18BP, Official Symbol IL18BPprovided by HGNC Official Full Name interleukin 18 binding proteinprovided by HGNC Primary source HGNC:HGNC:5987 See related Ensembl:ENSG00000137496 MIM:604113; AllianceGenome:HGNC:5987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FVH; IL18BPa Summary The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues See more Orthologs mouse all