CASP7, Official Symbol CASP7provided by HGNC Official Full Name caspase 7provided by HGNC Primary source HGNC:HGNC:1508 See related Ensembl:ENSG00000165806 MIM:601761; AllianceGenome:HGNC:1508 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3 Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Expression Broad expression in colon (RPKM 28.2), small intestine (RPKM 22.7) and 25 other tissues See more Orthologs mouse all