NLRC3, Official Symbol NLRC3provided by HGNC Official Full Name NLR family CARD domain containing 3provided by HGNC Primary source HGNC:HGNC:29889 See related Ensembl:ENSG00000167984 MIM:615648; AllianceGenome:HGNC:29889 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOD3; CLR16.2 Summary This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Broad expression in lymph node (RPKM 6.9), spleen (RPKM 4.9) and 23 other tissues See more Orthologs mouse all