PAIP2B, Official Symbol PAIP2Bprovided by HGNC Official Full Name poly(A) binding protein interacting protein 2Bprovided by HGNC Primary source HGNC:HGNC:29200 See related Ensembl:ENSG00000124374 MIM:611018; AllianceGenome:HGNC:29200 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008] Expression Broad expression in brain (RPKM 9.7), thyroid (RPKM 9.0) and 23 other tissues See more Orthologs mouse all