SMAD6, Official Symbol SMAD6provided by HGNC Official Full Name SMAD family member 6provided by HGNC Primary source HGNC:HGNC:6772 See related Ensembl:ENSG00000137834 MIM:602931; AllianceGenome:HGNC:6772 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AOVD2; MADH6; MADH7; HsT17432 Summary The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014] Expression Broad expression in lung (RPKM 6.3), placenta (RPKM 2.8) and 18 other tissues See more Orthologs mouse all