SDCBP, Official Symbol SDCBPprovided by HGNC Official Full Name syndecan binding proteinprovided by HGNC Primary source HGNC:HGNC:10662 See related Ensembl:ENSG00000137575 MIM:602217; AllianceGenome:HGNC:10662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ST1; MDA9; SYCL; MDA-9; SDCBP1; TACIP18 Summary The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in placenta (RPKM 77.0), gall bladder (RPKM 73.7) and 25 other tissues See more Orthologs mouse all