PPIA, Official Symbol PPIAprovided by HGNC Official Full Name peptidylprolyl isomerase Aprovided by HGNC Primary source HGNC:HGNC:9253 See related Ensembl:ENSG00000196262 MIM:123840; AllianceGenome:HGNC:9253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPA; CYPH; HEL-S-69p Summary This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 161.2), colon (RPKM 155.9) and 25 other tissues See more Orthologs mouse all