STS, Official Symbol STSprovided by HGNC Official Full Name steroid sulfataseprovided by HGNC Primary source HGNC:HGNC:11425 See related Ensembl:ENSG00000101846 MIM:300747; AllianceGenome:HGNC:11425 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ES; ASC; XLI; ARSC; SSDD; ARSC1 Summary This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016] Expression Broad expression in placenta (RPKM 15.1), fat (RPKM 11.7) and 22 other tissues See more Orthologs mouse all