SIRT1, Official Symbol SIRT1provided by HGNC Official Full Name sirtuin 1provided by HGNC Primary source HGNC:HGNC:14929 See related Ensembl:ENSG00000096717 MIM:604479; AllianceGenome:HGNC:14929 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2; SIR2L1; SIR2alpha Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] Expression Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues See more Orthologs mouse all