CD276, Official Symbol CD276provided by HGNC Official Full Name CD276 moleculeprovided by HGNC Primary source HGNC:HGNC:19137 See related Ensembl:ENSG00000103855 MIM:605715; AllianceGenome:HGNC:19137 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B7H3; B7-H3; B7RP-2; 4Ig-B7-H3 Summary The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues See more Orthologs mouse all