OCRL, Official Symbol OCRLprovided by HGNC Official Full Name OCRL inositol polyphosphate-5-phosphataseprovided by HGNC Primary source HGNC:HGNC:8108 See related Ensembl:ENSG00000122126 MIM:300535; AllianceGenome:HGNC:8108 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOCR; DENT2; NPHL2; OCRL1; Dent-2; INPP5F; OCRL-1 Summary This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Broad expression in testis (RPKM 21.7), adrenal (RPKM 15.8) and 25 other tissues See more Orthologs mouse all