COX4I2, Official Symbol COX4I2provided by HGNC Official Full Name cytochrome c oxidase subunit 4I2provided by HGNC Primary source HGNC:HGNC:16232 See related Ensembl:ENSG00000131055 MIM:607976; AllianceGenome:HGNC:16232 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2 Summary Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 32.5), lung (RPKM 10.0) and 6 other tissues See more Orthologs mouse all