DOCK8, Official Symbol DOCK8provided by HGNC Official Full Name dedicator of cytokinesis 8provided by HGNC Primary source HGNC:HGNC:19191 See related Ensembl:ENSG00000107099 MIM:611432; AllianceGenome:HGNC:19191 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRD2; ZIR8; HEL-205 Summary This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010] Expression Broad expression in lymph node (RPKM 24.2), spleen (RPKM 23.1) and 21 other tissues See more Orthologs mouse all