VPS4A, Official Symbol VPS4Aprovided by HGNC Official Full Name vacuolar protein sorting 4 homolog Aprovided by HGNC Primary source HGNC:HGNC:13488 See related Ensembl:ENSG00000132612 MIM:609982; AllianceGenome:HGNC:13488 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SKD1; SKD2; VPS4; SKD1A; CIMDAG; VPS4-1 Summary The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 45.1), fat (RPKM 36.4) and 25 other tissues See more Orthologs mouse all