ANGPTL3, Official Symbol ANGPTL3provided by HGNC Official Full Name angiopoietin like 3provided by HGNC Primary source HGNC:HGNC:491 See related Ensembl:ENSG00000132855 MIM:604774; AllianceGenome:HGNC:491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANL3; ANG-5; FHBL2; ANGPT5 Summary This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] Expression Restricted expression toward liver (RPKM 171.2) See more Orthologs mouse all