ADAMTS18, Official Symbol ADAMTS18provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 18provided by HGNC Primary source HGNC:HGNC:17110 See related Ensembl:ENSG00000140873 MIM:607512; AllianceGenome:HGNC:17110 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KNO2; MMCAT; ADAMTS21 Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016] Expression Biased expression in placenta (RPKM 9.8), endometrium (RPKM 0.6) and 1 other tissue See more Orthologs mouse all