CES2, Official Symbol CES2provided by HGNC Official Full Name carboxylesterase 2provided by HGNC Primary source HGNC:HGNC:1864 See related Ensembl:ENSG00000172831 MIM:605278; AllianceGenome:HGNC:1864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as iCE; CE-2; PCE-2; CES2A1 Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] Expression Biased expression in duodenum (RPKM 209.7), small intestine (RPKM 176.0) and 8 other tissues See more Orthologs all