NLRP10, Official Symbol NLRP10provided by HGNC Official Full Name NLR family pyrin domain containing 10provided by HGNC Primary source HGNC:HGNC:21464 See related Ensembl:ENSG00000182261 MIM:609662; AllianceGenome:HGNC:21464 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOD8; PAN5; PYNOD; NALP10; CLR11.1 Summary Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008] Expression Restricted expression toward skin (RPKM 2.7) See more Orthologs mouse all