ERAP2, Official Symbol ERAP2provided by HGNC Official Full Name endoplasmic reticulum aminopeptidase 2provided by HGNC Primary source HGNC:HGNC:29499 See related Ensembl:ENSG00000164308 MIM:609497; AllianceGenome:HGNC:29499 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRAP; L-RAP Summary This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016] Expression Broad expression in lymph node (RPKM 22.9), spleen (RPKM 19.0) and 23 other tissues See more Orthologs all