POLR2A, Official Symbol POLR2Aprovided by HGNC Official Full Name RNA polymerase II subunit Aprovided by HGNC Primary source HGNC:HGNC:9187 See related Ensembl:ENSG00000181222 MIM:180660; AllianceGenome:HGNC:9187 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; NEDHIB; RpIILS; hsRPB1; hRPB220 Summary This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in testis (RPKM 59.5), skin (RPKM 31.0) and 25 other tissues See more Orthologs mouse all