CD63, Official Symbol CD63provided by HGNC Official Full Name CD63 moleculeprovided by HGNC Primary source HGNC:HGNC:1692 See related Ensembl:ENSG00000135404 MIM:155740; AllianceGenome:HGNC:1692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD1; MLA1; ME491; HOP-26; OMA81H; Pltgp40; TSPAN30 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in fat (RPKM 184.8), colon (RPKM 181.1) and 25 other tissues See more Orthologs mouse all