CCDC88A, Official Symbol CCDC88Aprovided by HGNC Official Full Name coiled-coil domain containing 88Aprovided by HGNC Primary source HGNC:HGNC:25523 See related Ensembl:ENSG00000115355 MIM:609736; AllianceGenome:HGNC:25523 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APE; GIV; GRDN; PEHO; HkRP1; PEHOL; GIRDIN; KIAA1212 Summary This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Broad expression in testis (RPKM 20.8), brain (RPKM 15.3) and 23 other tissues See more Orthologs mouse all