ARHGEF11, Official Symbol ARHGEF11provided by HGNC Official Full Name Rho guanine nucleotide exchange factor 11provided by HGNC Primary source HGNC:HGNC:14580 See related Ensembl:ENSG00000132694 MIM:605708; AllianceGenome:HGNC:14580 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GTRAP48; PDZ-RHOGEF Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 7.8) and 25 other tissues See more Orthologs mouse all