NCOR1, Official Symbol NCOR1provided by HGNC Official Full Name nuclear receptor corepressor 1provided by HGNC Primary source HGNC:HGNC:7672 See related Ensembl:ENSG00000141027 MIM:600849; AllianceGenome:HGNC:7672 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109 Summary This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010] Expression Ubiquitous expression in thyroid (RPKM 10.9), colon (RPKM 10.7) and 25 other tissues See more Orthologs mouse all