GRM1, Official Symbol GRM1provided by HGNC Official Full Name glutamate metabotropic receptor 1provided by HGNC Primary source HGNC:HGNC:4593 See related Ensembl:ENSG00000152822 MIM:604473; AllianceGenome:HGNC:4593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85 Summary This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] Expression Biased expression in brain (RPKM 2.8), heart (RPKM 1.1) and 2 other tissues See more Orthologs mouse all