HAAO, Official Symbol HAAOprovided by HGNC Official Full Name 3-hydroxyanthranilate 3,4-dioxygenaseprovided by HGNC Primary source HGNC:HGNC:4796 See related Ensembl:ENSG00000162882 MIM:604521; AllianceGenome:HGNC:4796 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAO; 3-HAO; VCRL1; h3HAO Summary 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 28.1), kidney (RPKM 12.5) and 13 other tissues See more Orthologs mouse all