NBL1, Official Symbol NBL1provided by HGNC Official Full Name NBL1, DAN family BMP antagonistprovided by HGNC Primary source HGNC:HGNC:7650 See related Ensembl:ENSG00000158747 MIM:600613; AllianceGenome:HGNC:7650 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NB; DAN; NO3; DAND1; D1S1733E Summary This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013] Expression Broad expression in ovary (RPKM 113.9), prostate (RPKM 98.5) and 20 other tissues See more Orthologs mouse all