HCK, Official Symbol HCKprovided by HGNC Official Full Name HCK proto-oncogene, Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:4840 See related Ensembl:ENSG00000101336 MIM:142370; AllianceGenome:HGNC:4840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JTK9; AIPCV; p59Hck; p61Hck Summary The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010] Expression Broad expression in appendix (RPKM 55.1), spleen (RPKM 40.9) and 14 other tissues See more Orthologs mouse all