NPTX2, Official Symbol NPTX2provided by HGNC Official Full Name neuronal pentraxin 2provided by HGNC Primary source HGNC:HGNC:7953 See related Ensembl:ENSG00000106236 MIM:600750; AllianceGenome:HGNC:7953 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NP2; NARP; NP-II Summary This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009] Expression Biased expression in brain (RPKM 31.6), testis (RPKM 20.6) and 4 other tissues See more Orthologs mouse all