MCF2L, Official Symbol MCF2Lprovided by HGNC Official Full Name MCF.2 cell line derived transforming sequence likeprovided by HGNC Primary source HGNC:HGNC:14576 See related Ensembl:ENSG00000126217 MIM:609499; AllianceGenome:HGNC:14576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBS; OST; ARHGEF14 Summary This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in fat (RPKM 8.1), brain (RPKM 8.0) and 22 other tissues See more Orthologs mouse all