NKX2-6, Official Symbol NKX2-6provided by HGNC Official Full Name NK2 homeobox 6provided by HGNC Primary source HGNC:HGNC:32940 See related Ensembl:ENSG00000180053 MIM:611770; AllianceGenome:HGNC:32940 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSX2; CTHM; NKX2F; NKX4-2 Summary This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all