PTTG1, Official Symbol PTTG1provided by HGNC Official Full Name PTTG1 regulator of sister chromatid separation, securinprovided by HGNC Primary source HGNC:HGNC:9690 See related Ensembl:ENSG00000164611 MIM:604147; AllianceGenome:HGNC:9690 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAP1; PTTG; ECRAR; HPTTG; TUTR1 Summary The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] Expression Biased expression in testis (RPKM 44.0), bone marrow (RPKM 29.1) and 12 other tissues See more Orthologs mouse all