SLC39A14, Official Symbol SLC39A14provided by HGNC Official Full Name solute carrier family 39 member 14provided by HGNC Primary source HGNC:HGNC:20858 See related Ensembl:ENSG00000104635 MIM:608736; AllianceGenome:HGNC:20858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCIN; NET34; ZIP14; cig19; HMNDYT2; LZT-Hs4 Summary This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017] Expression Broad expression in liver (RPKM 83.2), duodenum (RPKM 51.4) and 20 other tissues See more Orthologs mouse all