HDAC6, Official Symbol HDAC6provided by HGNC Official Full Name histone deacetylase 6provided by HGNC Primary source HGNC:HGNC:14064 See related Ensembl:ENSG00000094631 MIM:300272; AllianceGenome:HGNC:14064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD6; JM21; CPBHM; PPP1R90 Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 18.6), testis (RPKM 15.9) and 25 other tissues See more Orthologs mouse all