HTRA4, Official Symbol HTRA4provided by HGNC Official Full Name HtrA serine peptidase 4provided by HGNC Primary source HGNC:HGNC:26909 See related Ensembl:ENSG00000169495 MIM:610700; AllianceGenome:HGNC:26909 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008] Expression Biased expression in placenta (RPKM 16.9) and bone marrow (RPKM 1.2) See more Orthologs mouse all