PSMA1, Official Symbol PSMA1provided by HGNC Official Full Name proteasome 20S subunit alpha 1provided by HGNC Primary source HGNC:HGNC:9530 See related Ensembl:ENSG00000129084 MIM:602854; AllianceGenome:HGNC:9530 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NU; HC2; PROS30; HEL-S-275 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] Expression Ubiquitous expression in appendix (RPKM 35.7), placenta (RPKM 35.1) and 25 other tissues See more Orthologs mouse all