HAND1, Official Symbol HAND1provided by HGNC Official Full Name heart and neural crest derivatives expressed 1provided by HGNC Primary source HGNC:HGNC:4807 See related Ensembl:ENSG00000113196 MIM:602406; AllianceGenome:HGNC:4807 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hxt; eHand; Thing1; bHLHa27 Summary The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 3.2), adrenal (RPKM 2.4) and 5 other tissues See more Orthologs mouse all