EDN1, Official Symbol EDN1provided by HGNC Official Full Name endothelin 1provided by HGNC Primary source HGNC:HGNC:3176 See related Ensembl:ENSG00000078401 MIM:131240; AllianceGenome:HGNC:3176 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ET1; QME; PPET1; ARCND3; HDLCQ7 Summary This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] Expression Broad expression in lung (RPKM 13.6), fat (RPKM 10.9) and 23 other tissues See more Orthologs mouse all