PIK3C2B, Official Symbol PIK3C2Bprovided by HGNC Official Full Name phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaprovided by HGNC Primary source HGNC:HGNC:8972 See related Ensembl:ENSG00000133056 MIM:602838; AllianceGenome:HGNC:8972 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2-PI3K Summary The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 8.8), skin (RPKM 7.4) and 24 other tissues See more Orthologs mouse all