CHCHD3, Official Symbol CHCHD3provided by HGNC Official Full Name coiled-coil-helix-coiled-coil-helix domain containing 3provided by HGNC Primary source HGNC:HGNC:21906 See related Ensembl:ENSG00000106554 MIM:613748; AllianceGenome:HGNC:21906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mic19; MINOS3; MICOS19; PPP1R22 Summary The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in heart (RPKM 24.9), duodenum (RPKM 14.8) and 25 other tissues See more Orthologs mouse all