PLA2G5, Official Symbol PLA2G5provided by HGNC Official Full Name phospholipase A2 group Vprovided by HGNC Primary source HGNC:HGNC:9038 See related Ensembl:ENSG00000127472 MIM:601192; AllianceGenome:HGNC:9038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRFB; GV-PLA2; PLA2-10; hVPLA(2) Summary This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues See more Orthologs all