TRIM2, Official Symbol TRIM2provided by HGNC Official Full Name tripartite motif containing 2provided by HGNC Primary source HGNC:HGNC:15974 See related Ensembl:ENSG00000109654 MIM:614141; AllianceGenome:HGNC:15974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMT2R; RNF86 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Expression Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues See more Orthologs mouse all