SPRED1, Official Symbol SPRED1provided by HGNC Official Full Name sprouty related EVH1 domain containing 1provided by HGNC Primary source HGNC:HGNC:20249 See related Ensembl:ENSG00000166068 MIM:609291; AllianceGenome:HGNC:20249 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LGSS; NFLS; hSpred1; spred-1; PPP1R147 Summary The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 21.9), brain (RPKM 13.6) and 23 other tissues See more Orthologs mouse all