TNFRSF4, Official Symbol TNFRSF4provided by HGNC Official Full Name TNF receptor superfamily member 4provided by HGNC Primary source HGNC:HGNC:11918 See related Ensembl:ENSG00000186827 MIM:600315; AllianceGenome:HGNC:11918 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX40; ACT35; CD134; IMD16; TXGP1L Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues See more Orthologs mouse all