H4C3, Official Symbol H4C3provided by HGNC Official Full Name H4 clustered histone 3provided by HGNC Primary source HGNC:HGNC:4787 See related Ensembl:ENSG00000197061 MIM:602827; AllianceGenome:HGNC:4787 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H4/g; H4C1; H4C2; H4C4; H4C5; H4C6; H4C8; H4C9; H4FG; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4C; TEVANED1; TEBIVANED1; dJ221C16.1 Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015] Orthologs mouse all