RFWD3, Official Symbol RFWD3provided by HGNC Official Full Name ring finger and WD repeat domain 3provided by HGNC Primary source HGNC:HGNC:25539 See related Ensembl:ENSG00000168411 MIM:614151; AllianceGenome:HGNC:25539 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FANCW; RNF201 Summary Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of DNA damage. Colocalizes with site of double-strand break. Implicated in Fanconi anemia. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 15.0), bone marrow (RPKM 14.7) and 25 other tissues See more Orthologs mouse all