UBXN8, Official Symbol UBXN8provided by HGNC Official Full Name UBX domain protein 8provided by HGNC Primary source HGNC:HGNC:30307 See related Ensembl:ENSG00000104691 MIM:602155; AllianceGenome:HGNC:30307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as REP8; UBXD6; D8S2298E Summary p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013] Expression Ubiquitous expression in ovary (RPKM 15.4), testis (RPKM 6.3) and 23 other tissues See more Orthologs mouse all