DNASE2B, Official Symbol DNASE2Bprovided by HGNC Official Full Name deoxyribonuclease 2 betaprovided by HGNC Primary source HGNC:HGNC:28875 See related Ensembl:ENSG00000137976 MIM:608057; AllianceGenome:HGNC:28875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DLAD Summary The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in salivary gland (RPKM 18.6) and prostate (RPKM 1.5) See more Orthologs mouse all