IKZF3, Official Symbol IKZF3provided by HGNC Official Full Name IKAROS family zinc finger 3provided by HGNC Primary source HGNC:HGNC:13178 See related Ensembl:ENSG00000161405 MIM:606221; AllianceGenome:HGNC:13178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIO; IMD84; AIOLOS; ZNFN1A3 Summary This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] Expression Biased expression in lymph node (RPKM 17.4), spleen (RPKM 11.5) and 10 other tissues See more Orthologs mouse all