FGF4, Official Symbol FGF4provided by HGNC Official Full Name fibroblast growth factor 4provided by HGNC Primary source HGNC:HGNC:3682 See related Ensembl:ENSG00000075388 MIM:164980; AllianceGenome:HGNC:3682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all