PAPSS2, Official Symbol PAPSS2provided by HGNC Official Full Name 3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by HGNC Primary source HGNC:HGNC:8604 See related Ensembl:ENSG00000198682 MIM:603005; AllianceGenome:HGNC:8604 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK2; BCYM4; ATPSK2 Summary Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 79.2), lung (RPKM 47.5) and 18 other tissues See more Orthologs mouse all