SGMS2, Official Symbol SGMS2provided by HGNC Official Full Name sphingomyelin synthase 2provided by HGNC Primary source HGNC:HGNC:28395 See related Ensembl:ENSG00000164023 MIM:611574; AllianceGenome:HGNC:28395 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDL; SMS2 Summary Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008] Expression Broad expression in gall bladder (RPKM 18.4), lung (RPKM 12.8) and 20 other tissues See more Orthologs mouse all