GLS, Official Symbol GLSprovided by HGNC Official Full Name glutaminaseprovided by HGNC Primary source HGNC:HGNC:4331 See related Ensembl:ENSG00000115419 MIM:138280; AllianceGenome:HGNC:4331 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAC; GAM; KGA; GLS1; AAD20; DEE71; GDPAG; CASGID; EIEE71 Summary This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Broad expression in kidney (RPKM 48.0), small intestine (RPKM 21.8) and 22 other tissues See more Orthologs mouse all