TRIO, Official Symbol TRIOprovided by HGNC Official Full Name trio Rho guanine nucleotide exchange factorprovided by HGNC Primary source HGNC:HGNC:12303 See related Ensembl:ENSG00000038382 MIM:601893; AllianceGenome:HGNC:12303 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as tgat; MEBAS; MRD44; MRD63; ARHGEF23 Summary This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in brain (RPKM 8.0), spleen (RPKM 6.0) and 25 other tissues See more Orthologs mouse all