KLF4, Official Symbol KLF4provided by HGNC Official Full Name KLF transcription factor 4provided by HGNC Primary source HGNC:HGNC:6348 See related Ensembl:ENSG00000136826 MIM:602253; AllianceGenome:HGNC:6348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EZF; GKLF Summary This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] Expression Broad expression in colon (RPKM 75.2), esophagus (RPKM 73.6) and 22 other tissues See more Orthologs mouse all