TIGIT, Official Symbol TIGITprovided by HGNC Official Full Name T cell immunoreceptor with Ig and ITIM domainsprovided by HGNC Primary source HGNC:HGNC:26838 See related Ensembl:ENSG00000181847 MIM:612859; AllianceGenome:HGNC:26838 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VSIG9; VSTM3; WUCAM Summary This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009] Expression Biased expression in lymph node (RPKM 15.1), spleen (RPKM 5.9) and 7 other tissues See more Orthologs mouse all