PKN1, Official Symbol PKN1provided by HGNC Official Full Name protein kinase N1provided by HGNC Primary source HGNC:HGNC:9405 See related Ensembl:ENSG00000123143 MIM:601032; AllianceGenome:HGNC:9405 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA Summary The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues See more Orthologs mouse all