PAX8, Official Symbol PAX8provided by HGNC Official Full Name paired box 8provided by HGNC Primary source HGNC:HGNC:8622 See related Ensembl:ENSG00000125618 MIM:167415; AllianceGenome:HGNC:8622 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAX-8 Summary This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] Expression Biased expression in thyroid (RPKM 261.2) and kidney (RPKM 40.3) See more Orthologs mouse all