ADAMTS12, Official Symbol ADAMTS12provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 12provided by HGNC Primary source HGNC:HGNC:14605 See related Ensembl:ENSG00000151388 MIM:606184; AllianceGenome:HGNC:14605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRO4389 Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 3.5), gall bladder (RPKM 2.0) and 19 other tissues See more Orthologs mouse all