MCM8, Official Symbol MCM8provided by HGNC Official Full Name minichromosome maintenance 8 homologous recombination repair factorprovided by HGNC Primary source HGNC:HGNC:16147 See related Ensembl:ENSG00000125885 MIM:608187; AllianceGenome:HGNC:16147 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POF10; C20orf154; dJ967N21.5 Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] Expression Broad expression in testis (RPKM 3.9), lymph node (RPKM 1.8) and 24 other tissues See more Orthologs mouse all