CDC16, Official Symbol CDC16provided by HGNC Official Full Name cell division cycle 16provided by HGNC Primary source HGNC:HGNC:1720 See related Ensembl:ENSG00000130177 MIM:603461; AllianceGenome:HGNC:1720 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APC6; CUT9; ANAPC6; CDC16Hs Summary The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues See more Orthologs mouse all