EPX, Official Symbol EPXprovided by HGNC Official Full Name eosinophil peroxidaseprovided by HGNC Primary source HGNC:HGNC:3423 See related Ensembl:ENSG00000121053 MIM:131399; AllianceGenome:HGNC:3423 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPO; EPP; EPXD; EPX-PEN Summary This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016] Expression Biased expression in bone marrow (RPKM 13.2) and spleen (RPKM 0.3) See more Orthologs mouse all