CLSPN, Official Symbol CLSPNprovided by HGNC Official Full Name claspinprovided by HGNC Primary source HGNC:HGNC:19715 See related Ensembl:ENSG00000092853 MIM:605434; AllianceGenome:HGNC:19715 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Expression Broad expression in bone marrow (RPKM 2.6), testis (RPKM 2.4) and 16 other tissues See more Orthologs mouse all