SIRT3, Official Symbol SIRT3provided by HGNC Official Full Name sirtuin 3provided by HGNC Primary source HGNC:HGNC:14931 See related Ensembl:ENSG00000142082 MIM:604481; AllianceGenome:HGNC:14931 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2L3 Summary SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019] Expression Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues See more Orthologs mouse all