FDFT1, Official Symbol FDFT1provided by HGNC Official Full Name farnesyl-diphosphate farnesyltransferase 1provided by HGNC Primary source HGNC:HGNC:3629 See related Ensembl:ENSG00000079459 MIM:184420; AllianceGenome:HGNC:3629 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SS; SQS; DGPT; ERG9; SQSD Summary This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 32.6), colon (RPKM 26.2) and 25 other tissues See more Orthologs mouse all