CNKSR2, Official Symbol CNKSR2provided by HGNC Official Full Name connector enhancer of kinase suppressor of Ras 2provided by HGNC Primary source HGNC:HGNC:19701 See related Ensembl:ENSG00000149970 MIM:300724; AllianceGenome:HGNC:19701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNK2; KSR2; MAGUIN; MRXSHG Summary This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Biased expression in brain (RPKM 9.7), adrenal (RPKM 1.3) and 2 other tissues See more Orthologs mouse all