PILRB, Official Symbol PILRBprovided by HGNC Official Full Name paired immunoglobin like type 2 receptor betaprovided by HGNC Primary source HGNC:HGNC:18297 See related Ensembl:ENSG00000121716 MIM:605342; AllianceGenome:HGNC:18297 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FDFACT1; FDFACT2 Summary The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in testis (RPKM 49.6), spleen (RPKM 35.1) and 25 other tissues See more Orthologs all