CRISP3, Official Symbol CRISP3provided by HGNC Official Full Name cysteine rich secretory protein 3provided by HGNC Primary source HGNC:HGNC:16904 See related Ensembl:ENSG00000096006 MIM:618062; AllianceGenome:HGNC:16904 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3 Summary This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] Expression Biased expression in salivary gland (RPKM 504.8), bone marrow (RPKM 138.4) and 1 other tissue See more Orthologs all