NTRK2, Official Symbol NTRK2provided by HGNC Official Full Name neurotrophic receptor tyrosine kinase 2provided by HGNC Primary source HGNC:HGNC:8032 See related Ensembl:ENSG00000148053 MIM:600456; AllianceGenome:HGNC:8032 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Biased expression in brain (RPKM 64.6), thyroid (RPKM 30.4) and 3 other tissues See more Orthologs mouse all