STAM2, Official Symbol STAM2provided by HGNC Official Full Name signal transducing adaptor molecule 2provided by HGNC Primary source HGNC:HGNC:11358 See related Ensembl:ENSG00000115145 MIM:606244; AllianceGenome:HGNC:11358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hbp; STAM2A; STAM2B Summary The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 10.8), thyroid (RPKM 10.4) and 25 other tissues See more Orthologs mouse all