AP2A1, Official Symbol AP2A1provided by HGNC Official Full Name adaptor related protein complex 2 subunit alpha 1provided by HGNC Primary source HGNC:HGNC:561 See related Ensembl:ENSG00000196961 MIM:601026; AllianceGenome:HGNC:561 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADTAA; CLAPA1; AP2-ALPHA Summary This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 42.9), brain (RPKM 24.7) and 25 other tissues See more Orthologs mouse all