IQGAP1, Official Symbol IQGAP1provided by HGNC Official Full Name IQ motif containing GTPase activating protein 1provided by HGNC Primary source HGNC:HGNC:6110 See related Ensembl:ENSG00000140575 MIM:603379; AllianceGenome:HGNC:6110 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAR1; p195; HUMORFA01 Summary This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 49.8), appendix (RPKM 48.4) and 25 other tissues See more Orthologs mouse all