KLK5, Official Symbol KLK5provided by HGNC Official Full Name kallikrein related peptidase 5provided by HGNC Primary source HGNC:HGNC:6366 See related Ensembl:ENSG00000167754 MIM:605643; AllianceGenome:HGNC:6366 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCTE; KLKL2; KLK-L2 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more Orthologs mouse all