SEMA5B, Official Symbol SEMA5Bprovided by HGNC Official Full Name semaphorin 5Bprovided by HGNC Primary source HGNC:HGNC:10737 See related Ensembl:ENSG00000082684 MIM:609298; AllianceGenome:HGNC:10737 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SemG; SEMAG Summary This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in brain (RPKM 2.8), heart (RPKM 1.3) and 16 other tissues See more Orthologs mouse all