CERKL, Official Symbol CERKLprovided by HGNC Official Full Name ceramide kinase likeprovided by HGNC Primary source HGNC:HGNC:21699 See related Ensembl:ENSG00000188452 MIM:608381; AllianceGenome:HGNC:21699 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP26 Summary This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010] Expression Broad expression in lymph node (RPKM 16.6), appendix (RPKM 16.2) and 20 other tissues See more Orthologs mouse all