DAD1, Official Symbol DAD1provided by HGNC Official Full Name defender against cell death 1provided by HGNC Primary source HGNC:HGNC:2664 See related Ensembl:ENSG00000129562 MIM:600243; AllianceGenome:HGNC:2664 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OST2 Summary DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 108.7), adrenal (RPKM 94.4) and 25 other tissues See more Orthologs mouse all