STRADA, Official Symbol STRADAprovided by HGNC Official Full Name STE20 related adaptor alphaprovided by HGNC Primary source HGNC:HGNC:30172 See related Ensembl:ENSG00000266173 MIM:608626; AllianceGenome:HGNC:30172 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha Summary The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009] Expression Broad expression in testis (RPKM 18.6), brain (RPKM 8.0) and 24 other tissues See more Orthologs mouse all