UBE2V1, Official Symbol UBE2V1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 V1provided by HGNC Primary source HGNC:HGNC:12494 See related Ensembl:ENSG00000244687 MIM:602995; AllianceGenome:HGNC:12494 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1 Summary Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in brain (RPKM 23.0), placenta (RPKM 20.8) and 25 other tissues See more Orthologs mouse all