PIGZ, Official Symbol PIGZprovided by HGNC Official Full Name phosphatidylinositol glycan anchor biosynthesis class Zprovided by HGNC Primary source HGNC:HGNC:30596 See related Ensembl:ENSG00000119227 MIM:611671; AllianceGenome:HGNC:30596 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMP3; PIG-Z; GPI-MT-IV Summary The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 5.3), brain (RPKM 1.9) and 20 other tissues See more Orthologs mouse all