HGS, Official Symbol HGSprovided by HGNC Official Full Name hepatocyte growth factor-regulated tyrosine kinase substrateprovided by HGNC Primary source HGNC:HGNC:4897 See related Ensembl:ENSG00000185359 MIM:604375; AllianceGenome:HGNC:4897 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRS Summary The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in testis (RPKM 20.7), bone marrow (RPKM 16.1) and 25 other tissues See more Orthologs mouse all