MARK4, Official Symbol MARK4provided by HGNC Official Full Name microtubule affinity regulating kinase 4provided by HGNC Primary source HGNC:HGNC:13538 See related Ensembl:ENSG00000007047 MIM:606495; AllianceGenome:HGNC:13538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L Summary This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues See more Orthologs mouse all