RIMS2, Official Symbol RIMS2provided by HGNC Official Full Name regulating synaptic membrane exocytosis 2provided by HGNC Primary source HGNC:HGNC:17283 See related Ensembl:ENSG00000176406 MIM:606630; AllianceGenome:HGNC:17283 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OBOE; RIM2; CRSDS; RAB3IP3 Summary The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017] Expression Biased expression in adrenal (RPKM 12.7), brain (RPKM 6.8) and 1 other tissue See more Orthologs mouse all