GANC, Official Symbol GANCprovided by HGNC Official Full Name glucosidase alpha, neutral Cprovided by HGNC Primary source HGNC:HGNC:4139 See related Ensembl:ENSG00000214013 MIM:104180; AllianceGenome:HGNC:4139 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014] Expression Ubiquitous expression in lung (RPKM 6.2), testis (RPKM 3.4) and 25 other tissues See more Orthologs mouse all