CRB2, Official Symbol CRB2provided by HGNC Official Full Name crumbs cell polarity complex component 2provided by HGNC Primary source HGNC:HGNC:18688 See related Ensembl:ENSG00000148204 MIM:609720; AllianceGenome:HGNC:18688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FSGS9; VMCKD Summary This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016] Expression Broad expression in brain (RPKM 3.7), kidney (RPKM 3.4) and 23 other tissues See more Orthologs mouse all