SETDB1, Official Symbol SETDB1provided by HGNC Official Full Name SET domain bifurcated histone lysine methyltransferase 1provided by HGNC Primary source HGNC:HGNC:10761 See related Ensembl:ENSG00000143379 MIM:604396; AllianceGenome:HGNC:10761 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4 Summary This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011] Expression Ubiquitous expression in testis (RPKM 14.6), spleen (RPKM 8.9) and 25 other tissues See more Orthologs mouse all