ITGA1, Official Symbol ITGA1provided by HGNC Official Full Name integrin subunit alpha 1provided by HGNC Primary source HGNC:HGNC:6134 See related Ensembl:ENSG00000213949 MIM:192968; AllianceGenome:HGNC:6134 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VLA1; CD49a Summary This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 48.2), placenta (RPKM 40.6) and 19 other tissues See more Orthologs mouse all