PDE7B, Official Symbol PDE7Bprovided by HGNC Official Full Name phosphodiesterase 7Bprovided by HGNC Primary source HGNC:HGNC:8792 See related Ensembl:ENSG00000171408 MIM:604645; AllianceGenome:HGNC:8792 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bA472E5.1 Summary The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009] Expression Ubiquitous expression in ovary (RPKM 3.7), endometrium (RPKM 2.5) and 22 other tissues See more Orthologs mouse all