LCP2, Official Symbol LCP2provided by HGNC Official Full Name lymphocyte cytosolic protein 2provided by HGNC Primary source HGNC:HGNC:6529 See related Ensembl:ENSG00000043462 MIM:601603; AllianceGenome:HGNC:6529 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD81; SLP76; SLP-76 Summary This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016] Expression Broad expression in bone marrow (RPKM 53.7), appendix (RPKM 44.7) and 19 other tissues See more Orthologs mouse all