BAD, Official Symbol BADprovided by HGNC Official Full Name BCL2 associated agonist of cell deathprovided by HGNC Primary source HGNC:HGNC:936 See related Ensembl:ENSG00000002330 MIM:603167; AllianceGenome:HGNC:936 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BBC2; BCL2L8 Summary The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019] Expression Ubiquitous expression in colon (RPKM 20.0), fat (RPKM 18.4) and 25 other tissues See more Orthologs mouse all