LATS2, Official Symbol LATS2provided by HGNC Official Full Name large tumor suppressor kinase 2provided by HGNC Primary source HGNC:HGNC:6515 See related Ensembl:ENSG00000150457 MIM:604861; AllianceGenome:HGNC:6515 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KPM Summary This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more Orthologs mouse all