RNASE1, Official Symbol RNASE1provided by HGNC Official Full Name ribonuclease A family member 1, pancreaticprovided by HGNC Primary source HGNC:HGNC:10044 See related Ensembl:ENSG00000129538 MIM:180440; AllianceGenome:HGNC:10044 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAC1; RIB1; RNS1 Summary This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues See more Orthologs mouse all