HGF, Official Symbol HGFprovided by HGNC Official Full Name hepatocyte growth factorprovided by HGNC Primary source HGNC:HGNC:4893 See related Ensembl:ENSG00000019991 MIM:142409; AllianceGenome:HGNC:4893 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SF; HGFB; HPTA; F-TCF; DFNB39 Summary This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015] Expression Biased expression in placenta (RPKM 90.6), adrenal (RPKM 7.0) and 2 other tissues See more Orthologs mouse all