CBFA2T2, Official Symbol CBFA2T2provided by HGNC Official Full Name CBFA2/RUNX1 partner transcriptional co-repressor 2provided by HGNC Primary source HGNC:HGNC:1536 See related Ensembl:ENSG00000078699 MIM:603672; AllianceGenome:HGNC:1536 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EHT; p85; MTGR1; ZMYND3 Summary In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 6.7), testis (RPKM 4.3) and 25 other tissues See more Orthologs mouse all