NECTIN3, Official Symbol NECTIN3provided by HGNC Official Full Name nectin cell adhesion molecule 3provided by HGNC Primary source HGNC:HGNC:17664 See related Ensembl:ENSG00000177707 MIM:607147; AllianceGenome:HGNC:17664 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3 Summary This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Broad expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 22 other tissues See more Orthologs mouse all