HCFC2, Official Symbol HCFC2provided by HGNC Official Full Name host cell factor C2provided by HGNC Primary source HGNC:HGNC:24972 See related Ensembl:ENSG00000111727 MIM:607926; AllianceGenome:HGNC:24972 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCF2; HCF-2 Summary This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 10.0), endometrium (RPKM 3.8) and 25 other tissues See more Orthologs mouse all