ELOA, Official Symbol ELOAprovided by HGNC Official Full Name elongin Aprovided by HGNC Primary source HGNC:HGNC:11620 See related Ensembl:ENSG00000011007 MIM:600786; AllianceGenome:HGNC:11620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIII; ELOA1; TCEB3; TCEB3A; SIII p110 Summary This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 15.9), thyroid (RPKM 14.1) and 25 other tissues See more Orthologs mouse all