GLP1R, Official Symbol GLP1Rprovided by HGNC Official Full Name glucagon like peptide 1 receptorprovided by HGNC Primary source HGNC:HGNC:4324 See related Ensembl:ENSG00000112164 MIM:138032; AllianceGenome:HGNC:4324 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLP-1; GLP-1R; GLP-1-R Summary This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] Expression Biased expression in heart (RPKM 1.0), brain (RPKM 1.0) and 10 other tissues See more Orthologs mouse all