MARVELD3, Official Symbol MARVELD3provided by HGNC Official Full Name MARVEL domain containing 3provided by HGNC Primary source HGNC:HGNC:30525 See related Ensembl:ENSG00000140832 MIM:614094; AllianceGenome:HGNC:30525 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARVD3; MRVLDC3 Summary Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Located in bicellular tight junction and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in small intestine (RPKM 6.8), colon (RPKM 6.5) and 18 other tissues See more Orthologs mouse all