PTGER1, Official Symbol PTGER1provided by HGNC Official Full Name prostaglandin E receptor 1provided by HGNC Primary source HGNC:HGNC:9593 See related Ensembl:ENSG00000160951 MIM:176802; AllianceGenome:HGNC:9593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EP1 Summary The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 4.8), spleen (RPKM 1.1) and 3 other tissues See more Orthologs mouse all