HTR6, Official Symbol HTR6provided by HGNC Official Full Name 5-hydroxytryptamine receptor 6provided by HGNC Primary source HGNC:HGNC:5301 See related Ensembl:ENSG00000158748 MIM:601109; AllianceGenome:HGNC:5301 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 5-HT6; 5-HT6R Summary This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all