MARCHF1, Official Symbol MARCHF1provided by HGNC Official Full Name membrane associated ring-CH-type finger 1provided by HGNC Primary source HGNC:HGNC:26077 See related Ensembl:ENSG00000145416 MIM:613331; AllianceGenome:HGNC:26077 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH1; RNF171; MARCH-I Summary MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010] Expression Broad expression in lymph node (RPKM 10.3), spleen (RPKM 8.7) and 21 other tissues See more Orthologs mouse all