IBSP, Official Symbol IBSPprovided by HGNC Official Full Name integrin binding sialoproteinprovided by HGNC Primary source HGNC:HGNC:5341 See related Ensembl:ENSG00000029559 MIM:147563; AllianceGenome:HGNC:5341 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BSP; BNSP; SP-II; BSP-II Summary The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all