RNF216, Official Symbol RNF216provided by HGNC Official Full Name ring finger protein 216provided by HGNC Primary source HGNC:HGNC:21698 See related Ensembl:ENSG00000011275 MIM:609948; AllianceGenome:HGNC:21698 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZIN; CAHH; U7I1; TRIAD3; UBCE7IP1 Summary This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 16.3), lymph node (RPKM 10.2) and 25 other tissues See more Orthologs mouse all