AKR1C4, Official Symbol AKR1C4provided by HGNC Official Full Name aldo-keto reductase family 1 member C4provided by HGNC Primary source HGNC:HGNC:387 See related Ensembl:ENSG00000198610 MIM:600451; AllianceGenome:HGNC:387 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 165.8) See more Orthologs all