MMP15, Official Symbol MMP15provided by HGNC Official Full Name matrix metallopeptidase 15provided by HGNC Primary source HGNC:HGNC:7161 See related Ensembl:ENSG00000102996 MIM:602261; AllianceGenome:HGNC:7161 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMP Summary This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016] Expression Broad expression in thyroid (RPKM 28.2), placenta (RPKM 20.0) and 22 other tissues See more Orthologs mouse all