TNFAIP3, Official Symbol TNFAIP3provided by HGNC Official Full Name TNF alpha induced protein 3provided by HGNC Primary source HGNC:HGNC:11896 See related Ensembl:ENSG00000118503 MIM:191163; AllianceGenome:HGNC:11896 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A20; AISBL; AIFBL1; OTUD7C; TNFA1P2 Summary This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012] Expression Broad expression in bone marrow (RPKM 156.2), appendix (RPKM 61.9) and 14 other tissues See more Orthologs mouse all