LZTS1, Official Symbol LZTS1provided by HGNC Official Full Name leucine zipper tumor suppressor 1provided by HGNC Primary source HGNC:HGNC:13861 See related Ensembl:ENSG00000061337 MIM:606551; AllianceGenome:HGNC:13861 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as F37; FEZ1 Summary This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009] Expression Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues See more Orthologs mouse all