MTREX, Official Symbol MTREXprovided by HGNC Official Full Name Mtr4 exosome RNA helicaseprovided by HGNC Primary source HGNC:HGNC:18734 See related Ensembl:ENSG00000039123 MIM:618122; AllianceGenome:HGNC:18734 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Dob1; Mtr4; SKIV2L2; fSAP118; KIAA0052 Summary Enables ATP binding activity and RNA helicase activity. Involved in RNA catabolic process; cellular response to DNA damage stimulus; and maturation of 5.8S rRNA. Located in nucleoplasm. Part of TRAMP complex and catalytic step 2 spliceosome. Colocalizes with nuclear exosome (RNase complex). Biomarker of amyotrophic lateral sclerosis. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 29.9), gall bladder (RPKM 23.3) and 25 other tissues See more Orthologs mouse all