CFL1, Official Symbol CFL1provided by HGNC Official Full Name cofilin 1provided by HGNC Primary source HGNC:HGNC:1874 See related Ensembl:ENSG00000172757 MIM:601442; AllianceGenome:HGNC:1874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CFL; cofilin; HEL-S-15 Summary The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in duodenum (RPKM 413.9), colon (RPKM 411.4) and 25 other tissues See more Orthologs mouse all