UHRF2, Official Symbol UHRF2provided by HGNC Official Full Name ubiquitin like with PHD and ring finger domains 2provided by HGNC Primary source HGNC:HGNC:12557 See related Ensembl:ENSG00000147854 MIM:615211; AllianceGenome:HGNC:12557 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIRF; URF2; RNF107; TDRD23 Summary This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in bone marrow (RPKM 16.7), lymph node (RPKM 12.5) and 25 other tissues See more Orthologs mouse all