AGO3, Official Symbol AGO3provided by HGNC Official Full Name argonaute RISC catalytic component 3provided by HGNC Primary source HGNC:HGNC:18421 See related Ensembl:ENSG00000126070 MIM:607355; AllianceGenome:HGNC:18421 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF2C3 Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 1.4), testis (RPKM 1.4) and 25 other tissues See more Orthologs mouse all