ARHGEF6, Official Symbol ARHGEF6provided by HGNC Official Full Name Rac/Cdc42 guanine nucleotide exchange factor 6provided by HGNC Primary source HGNC:HGNC:685 See related Ensembl:ENSG00000129675 MIM:300267; AllianceGenome:HGNC:685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 22.0), lymph node (RPKM 16.8) and 24 other tissues See more Orthologs mouse all