CRYM, Official Symbol CRYMprovided by HGNC Official Full Name crystallin muprovided by HGNC Primary source HGNC:HGNC:2418 See related Ensembl:ENSG00000103316 MIM:123740; AllianceGenome:HGNC:2418 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as THBP; DFNA40 Summary Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014] Expression Biased expression in heart (RPKM 46.6), brain (RPKM 32.2) and 9 other tissues See more Orthologs mouse all