DUSP18, Official Symbol DUSP18provided by HGNC Official Full Name dual specificity phosphatase 18provided by HGNC Primary source HGNC:HGNC:18484 See related Ensembl:ENSG00000167065 MIM:611446; AllianceGenome:HGNC:18484 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSP18; DUSP20; LMWDSP20 Summary Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] Expression Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues See more Orthologs mouse all