MATK, Official Symbol MATKprovided by HGNC Official Full Name megakaryocyte-associated tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:6906 See related Ensembl:ENSG00000007264 MIM:600038; AllianceGenome:HGNC:6906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHK; CTK; HYL; Lsk; HYLTK; HHYLTK Summary The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 4.5), bone marrow (RPKM 3.5) and 19 other tissues See more Orthologs mouse all