RYR2, Official Symbol RYR2provided by HGNC Official Full Name ryanodine receptor 2provided by HGNC Primary source HGNC:HGNC:10484 See related Ensembl:ENSG00000198626 MIM:180902; AllianceGenome:HGNC:10484 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RyR; ARVC2; ARVD2; RYR-2; VTSIP; VACRDS Summary This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 47.0) and brain (RPKM 4.2) See more Orthologs mouse all