MYO15A, Official Symbol MYO15Aprovided by HGNC Official Full Name myosin XVAprovided by HGNC Primary source HGNC:HGNC:7594 See related Ensembl:ENSG00000091536 MIM:602666; AllianceGenome:HGNC:7594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB3; MYO15 Summary This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 1.5), ovary (RPKM 0.3) and 6 other tissues See more Orthologs mouse all