SHMT1, Official Symbol SHMT1provided by HGNC Official Full Name serine hydroxymethyltransferase 1provided by HGNC Primary source HGNC:HGNC:10850 See related Ensembl:ENSG00000176974 MIM:182144; AllianceGenome:HGNC:10850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHMT; CSHMT Summary This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Biased expression in kidney (RPKM 121.9), liver (RPKM 84.9) and 13 other tissues See more Orthologs mouse all