CLEC4E, Official Symbol CLEC4Eprovided by HGNC Official Full Name C-type lectin domain family 4 member Eprovided by HGNC Primary source HGNC:HGNC:14555 See related Ensembl:ENSG00000166523 MIM:609962; AllianceGenome:HGNC:14555 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MINCLE; CLECSF9 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 10.3), spleen (RPKM 8.6) and 11 other tissues See more Orthologs mouse all