PLCD3, Official Symbol PLCD3provided by HGNC Official Full Name phospholipase C delta 3provided by HGNC Primary source HGNC:HGNC:9061 See related Ensembl:ENSG00000161714 MIM:608795; AllianceGenome:HGNC:9061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLC-delta-3 Summary This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues See more Orthologs mouse all