RUBCN, Official Symbol RUBCNprovided by HGNC Official Full Name rubicon autophagy regulatorprovided by HGNC Primary source HGNC:HGNC:28991 See related Ensembl:ENSG00000145016 MIM:613516; AllianceGenome:HGNC:28991 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCAR15; RUBICON; KIAA0226 Summary The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 6.7) and 25 other tissues See more Orthologs mouse all