PNPLA8, Official Symbol PNPLA8provided by HGNC Official Full Name patatin like phospholipase domain containing 8provided by HGNC Primary source HGNC:HGNC:28900 See related Ensembl:ENSG00000135241 MIM:612123; AllianceGenome:HGNC:28900 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMLA; IPLA2G; IPLA2-2; iPLA2gamma; PNPLA-gamma Summary This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015] Expression Ubiquitous expression in bone marrow (RPKM 15.3), adrenal (RPKM 14.6) and 25 other tissues See more Orthologs mouse all