CDC42BPA, Official Symbol CDC42BPAprovided by HGNC Official Full Name CDC42 binding protein kinase alphaprovided by HGNC Primary source HGNC:HGNC:1737 See related Ensembl:ENSG00000143776 MIM:603412; AllianceGenome:HGNC:1737 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRCK; MRCKA; PK428; MRCKalpha Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018] Expression Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues See more Orthologs mouse all