HIF3A, Official Symbol HIF3Aprovided by HGNC Official Full Name hypoxia inducible factor 3 subunit alphaprovided by HGNC Primary source HGNC:HGNC:15825 See related Ensembl:ENSG00000124440 MIM:609976; AllianceGenome:HGNC:15825 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPAS; MOP7; PASD7; HIF-3A; bHLHe17; HIF3-alpha-1 Summary The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] Expression Broad expression in placenta (RPKM 8.3), spleen (RPKM 6.6) and 17 other tissues See more Orthologs mouse all