SIVA1, Official Symbol SIVA1provided by HGNC Official Full Name SIVA1 apoptosis inducing factorprovided by HGNC Primary source HGNC:HGNC:17712 See related Ensembl:ENSG00000184990 MIM:605567; AllianceGenome:HGNC:17712 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIVA; CD27BP; Siva-1; Siva-2 Summary This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018] Expression Ubiquitous expression in bone marrow (RPKM 15.7), fat (RPKM 10.9) and 25 other tissues See more Orthologs mouse all