DHX58, Official Symbol DHX58provided by HGNC Official Full Name DExH-box helicase 58provided by HGNC Primary source HGNC:HGNC:29517 See related Ensembl:ENSG00000108771 MIM:608588; AllianceGenome:HGNC:29517 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LGP2; RLR-3; D11LGP2; D11lgp2e Summary Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues See more Orthologs mouse all