CARD11, Official Symbol CARD11provided by HGNC Official Full Name caspase recruitment domain family member 11provided by HGNC Primary source HGNC:HGNC:16393 See related Ensembl:ENSG00000198286 MIM:607210; AllianceGenome:HGNC:16393 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A Summary The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 19.0), spleen (RPKM 15.1) and 10 other tissues See more Orthologs mouse all