DGUOK, Official Symbol DGUOKprovided by HGNC Official Full Name deoxyguanosine kinaseprovided by HGNC Primary source HGNC:HGNC:2858 See related Ensembl:ENSG00000114956 MIM:601465; AllianceGenome:HGNC:2858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dGK; NCPH; NCPH1; PEOB4; MTDPS3 Summary In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 20.4), lymph node (RPKM 18.7) and 25 other tissues See more Orthologs mouse all