OSGIN1, Official Symbol OSGIN1provided by HGNC Official Full Name oxidative stress induced growth inhibitor 1provided by HGNC Primary source HGNC:HGNC:30093 See related Ensembl:ENSG00000140961 MIM:607975; AllianceGenome:HGNC:30093 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDGI; OKL38 Summary This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011] Expression Broad expression in liver (RPKM 32.8), duodenum (RPKM 12.4) and 14 other tissues See more Orthologs mouse all