CSNK1A1, Official Symbol CSNK1A1provided by HGNC Official Full Name casein kinase 1 alpha 1provided by HGNC Primary source HGNC:HGNC:2451 See related Ensembl:ENSG00000113712 MIM:600505; AllianceGenome:HGNC:2451 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p Summary Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 69.2), gall bladder (RPKM 47.2) and 25 other tissues See more Orthologs mouse all