C5AR2, Official Symbol C5AR2provided by HGNC Official Full Name complement C5a receptor 2provided by HGNC Primary source HGNC:HGNC:4527 See related Ensembl:ENSG00000134830 MIM:609949; AllianceGenome:HGNC:4527 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C5L2; GPF77; GPR77 Summary This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] Expression Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues See more Orthologs mouse all