TBC1D5, Official Symbol TBC1D5provided by HGNC Official Full Name TBC1 domain family member 5provided by HGNC Primary source HGNC:HGNC:19166 See related Ensembl:ENSG00000131374 MIM:615740; AllianceGenome:HGNC:19166 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in Golgi apparatus; autophagosome; and endosome membrane. Part of retromer complex. Colocalizes with AP-2 adaptor complex and Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 11.6), brain (RPKM 10.8) and 25 other tissues See more Orthologs mouse all