CDC23, Official Symbol CDC23provided by HGNC Official Full Name cell division cycle 23provided by HGNC Primary source HGNC:HGNC:1724 See related Ensembl:ENSG00000094880 MIM:603462; AllianceGenome:HGNC:1724 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APC8; CUT23; ANAPC8 Summary The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues See more Orthologs mouse all