TRIB3, Official Symbol TRIB3provided by HGNC Official Full Name tribbles pseudokinase 3provided by HGNC Primary source HGNC:HGNC:16228 See related Ensembl:ENSG00000101255 MIM:607898; AllianceGenome:HGNC:16228 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIPK; SINK; TRB3; SKIP3; C20orf97 Summary The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues See more Orthologs mouse all