HAL, Official Symbol HALprovided by HGNC Official Full Name histidine ammonia-lyaseprovided by HGNC Primary source HGNC:HGNC:4806 See related Ensembl:ENSG00000084110 MIM:609457; AllianceGenome:HGNC:4806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HIS; HSTD Summary Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Expression Biased expression in skin (RPKM 20.5), liver (RPKM 18.5) and 2 other tissues See more Orthologs mouse all