SENP5, Official Symbol SENP5provided by HGNC Official Full Name SUMO specific peptidase 5provided by HGNC Primary source HGNC:HGNC:28407 See related Ensembl:ENSG00000119231 MIM:612845; AllianceGenome:HGNC:28407 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009] Expression Ubiquitous expression in testis (RPKM 8.4), brain (RPKM 6.3) and 25 other tissues See more Orthologs mouse all