VRK1, Official Symbol VRK1provided by HGNC Official Full Name VRK serine/threonine kinase 1provided by HGNC Primary source HGNC:HGNC:12718 See related Ensembl:ENSG00000100749 MIM:602168; AllianceGenome:HGNC:12718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCH1; PCH1A Summary This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 15.9), testis (RPKM 12.9) and 23 other tissues See more Orthologs mouse all