RTN2, Official Symbol RTN2provided by HGNC Official Full Name reticulon 2provided by HGNC Primary source HGNC:HGNC:10468 See related Ensembl:ENSG00000125744 MIM:603183; AllianceGenome:HGNC:10468 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSP2; NSPL1; NSPLI; SPG12 Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020] Expression Broad expression in brain (RPKM 9.6), placenta (RPKM 7.1) and 22 other tissues See more Orthologs mouse all