AEN, Official Symbol AENprovided by HGNC Official Full Name apoptosis enhancing nucleaseprovided by HGNC Primary source HGNC:HGNC:25722 See related Ensembl:ENSG00000181026 MIM:610177; AllianceGenome:HGNC:25722 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ISG20L1; pp12744 Summary Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 5.8), thyroid (RPKM 5.8) and 25 other tissues See more Orthologs mouse all