SLC27A2, Official Symbol SLC27A2provided by HGNC Official Full Name solute carrier family 27 member 2provided by HGNC Primary source HGNC:HGNC:10996 See related Ensembl:ENSG00000140284 MIM:603247; AllianceGenome:HGNC:10996 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VLCS; FATP2; VLACS; ACSVL1; FACVL1; hFACVL1; HsT17226 Summary The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] Expression Biased expression in liver (RPKM 63.2), kidney (RPKM 62.8) and 5 other tissues See more Orthologs mouse all