PRELP, Official Symbol PRELPprovided by HGNC Official Full Name proline and arginine rich end leucine rich repeat proteinprovided by HGNC Primary source HGNC:HGNC:9357 See related Ensembl:ENSG00000188783 MIM:601914; AllianceGenome:HGNC:9357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST161; SLRR2A; MSTP161 Summary The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 42.7), fat (RPKM 41.5) and 22 other tissues See more Orthologs mouse all