APELA, Official Symbol APELAprovided by HGNC Official Full Name apelin receptor early endogenous ligandprovided by HGNC Primary source HGNC:HGNC:48925 See related Ensembl:ENSG00000248329 MIM:615594; AllianceGenome:HGNC:48925 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ELA; tdl; Ende Summary This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016] Expression Biased expression in prostate (RPKM 1.8), kidney (RPKM 0.5) and 2 other tissues See more Orthologs mouse all