SEC31A, Official Symbol SEC31Aprovided by HGNC Official Full Name SEC31 homolog A, COPII coat complex componentprovided by HGNC Primary source HGNC:HGNC:17052 See related Ensembl:ENSG00000138674 MIM:610257; AllianceGenome:HGNC:17052 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1 Summary The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in ovary (RPKM 48.8), thyroid (RPKM 42.6) and 25 other tissues See more Orthologs mouse all