BIRC7, Official Symbol BIRC7provided by HGNC Official Full Name baculoviral IAP repeat containing 7provided by HGNC Primary source HGNC:HGNC:13702 See related Ensembl:ENSG00000101197 MIM:605737; AllianceGenome:HGNC:13702 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAP; LIVIN; MLIAP; RNF50; ML-IAP Summary This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013] Expression Biased expression in placenta (RPKM 3.1), skin (RPKM 0.7) and 5 other tissues See more Orthologs mouse all