SCN11A, Official Symbol SCN11Aprovided by HGNC Official Full Name sodium voltage-gated channel alpha subunit 11provided by HGNC Primary source HGNC:HGNC:10583 See related Ensembl:ENSG00000168356 MIM:604385; AllianceGenome:HGNC:10583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NaN; PN5; FEPS3; HSAN7; SNS-2; NAV1.9; SCN12A Summary Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017] Expression Biased expression in spleen (RPKM 1.9), placenta (RPKM 0.6) and 13 other tissues See more Orthologs mouse all