TPT1, Official Symbol TPT1provided by HGNC Official Full Name tumor protein, translationally-controlled 1provided by HGNC Primary source HGNC:HGNC:12022 See related Ensembl:ENSG00000133112 MIM:600763; AllianceGenome:HGNC:12022 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRF; p02; p23; TCTP Summary This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues See more Orthologs mouse all