INMT, Official Symbol INMTprovided by HGNC Official Full Name indolethylamine N-methyltransferaseprovided by HGNC Primary source HGNC:HGNC:6069 See related Ensembl:ENSG00000241644 MIM:604854; AllianceGenome:HGNC:6069 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEMT Summary N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019] Expression Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues See more Orthologs mouse all