AQP3, Official Symbol AQP3provided by HGNC Official Full Name aquaporin 3 (Gill blood group)provided by HGNC Primary source HGNC:HGNC:636 See related Ensembl:ENSG00000165272 MIM:600170; AllianceGenome:HGNC:636 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIL; AQP-3 Summary This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Expression Biased expression in esophagus (RPKM 430.5), skin (RPKM 178.1) and 9 other tissues See more Orthologs mouse all