BEX2, Official Symbol BEX2provided by HGNC Official Full Name brain expressed X-linked 2provided by HGNC Primary source HGNC:HGNC:30933 See related Ensembl:ENSG00000133134 MIM:300691; AllianceGenome:HGNC:30933 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BEX1; DJ79P11.1 Summary This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Broad expression in brain (RPKM 60.5), thyroid (RPKM 40.0) and 14 other tissues See more Orthologs mouse all