SLPI, Official Symbol SLPIprovided by HGNC Official Full Name secretory leukocyte peptidase inhibitorprovided by HGNC Primary source HGNC:HGNC:11092 See related Ensembl:ENSG00000124107 MIM:107285; AllianceGenome:HGNC:11092 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I Summary This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014] Expression Biased expression in salivary gland (RPKM 1077.5), lung (RPKM 390.4) and 4 other tissues See more Orthologs mouse all