HACE1, Official Symbol HACE1provided by HGNC Official Full Name HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:21033 See related Ensembl:ENSG00000085382 MIM:610876; AllianceGenome:HGNC:21033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPPRS Summary This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016] Expression Broad expression in placenta (RPKM 13.5), testis (RPKM 6.0) and 22 other tissues See more Orthologs mouse all