CBLB, Official Symbol CBLBprovided by HGNC Official Full Name Cbl proto-oncogene Bprovided by HGNC Primary source HGNC:HGNC:1542 See related Ensembl:ENSG00000114423 MIM:604491; AllianceGenome:HGNC:1542 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cbl-b; RNF56; ADMIO3; Nbla00127 Summary This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017] Expression Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues See more Orthologs mouse all