APLF, Official Symbol APLFprovided by HGNC Official Full Name aprataxin and PNKP like factorprovided by HGNC Primary source HGNC:HGNC:28724 See related Ensembl:ENSG00000169621 MIM:611035; AllianceGenome:HGNC:28724 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APFL; PALF; Xip1; ZCCHH1; C2orf13 Summary Enables DNA-(apurinic or apyrimidinic site) endonuclease activity; nuclease activity; and nucleotide binding activity. Involved in double-strand break repair via nonhomologous end joining and single strand break repair. Acts upstream of or within positive regulation of DNA ligation. Located in nucleoplasm. Is active in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 1.6), skin (RPKM 1.2) and 24 other tissues See more Orthologs mouse all