TMEM123, Official Symbol TMEM123provided by HGNC Official Full Name transmembrane protein 123provided by HGNC Primary source HGNC:HGNC:30138 See related Ensembl:ENSG00000152558 MIM:606356; AllianceGenome:HGNC:30138 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KCT3; PORMIN; PORIMIN Summary This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 170.2), endometrium (RPKM 103.2) and 25 other tissues See more Orthologs mouse all