CABIN1, Official Symbol CABIN1provided by HGNC Official Full Name calcineurin binding protein 1provided by HGNC Primary source HGNC:HGNC:24187 See related Ensembl:ENSG00000099991 MIM:604251; AllianceGenome:HGNC:24187 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAIN; PPP3IN; KB-318B8.7 Summary Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in thyroid (RPKM 6.8), testis (RPKM 6.2) and 25 other tissues See more Orthologs mouse all