PKMYT1, Official Symbol PKMYT1provided by HGNC Official Full Name protein kinase, membrane associated tyrosine/threonine 1provided by HGNC Primary source HGNC:HGNC:29650 See related Ensembl:ENSG00000127564 MIM:602474; AllianceGenome:HGNC:29650 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYT1; PPP1R126 Summary This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Expression Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues See more Orthologs mouse all