PGGT1B, Official Symbol PGGT1Bprovided by HGNC Official Full Name protein geranylgeranyltransferase type I subunit betaprovided by HGNC Primary source HGNC:HGNC:8895 See related Ensembl:ENSG00000164219 MIM:602031; AllianceGenome:HGNC:8895 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BGGI; GGTI Summary Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in colon (RPKM 3.0), spleen (RPKM 2.3) and 25 other tissues See more Orthologs mouse all