TSPO, Official Symbol TSPOprovided by HGNC Official Full Name translocator proteinprovided by HGNC Primary source HGNC:HGNC:1158 See related Ensembl:ENSG00000100300 MIM:109610; AllianceGenome:HGNC:1158 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18; TSPO1 Summary Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012] Expression Broad expression in bone marrow (RPKM 105.6), fat (RPKM 61.4) and 20 other tissues See more Orthologs mouse all