CYP19A1, Official Symbol CYP19A1provided by HGNC Official Full Name cytochrome P450 family 19 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2594 See related Ensembl:ENSG00000137869 MIM:107910; AllianceGenome:HGNC:2594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016] Expression Restricted expression toward placenta (RPKM 83.2) See more Orthologs mouse all