TECTA, Official Symbol TECTAprovided by HGNC Official Full Name tectorin alphaprovided by HGNC Primary source HGNC:HGNC:11720 See related Ensembl:ENSG00000109927 MIM:602574; AllianceGenome:HGNC:11720 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNA8; DFNA12; DFNB21 Summary The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 1.1), testis (RPKM 0.6) and 24 other tissues See more Orthologs mouse all