S1PR5, Official Symbol S1PR5provided by HGNC Official Full Name sphingosine-1-phosphate receptor 5provided by HGNC Primary source HGNC:HGNC:14299 See related Ensembl:ENSG00000180739 MIM:605146; AllianceGenome:HGNC:14299 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDG8; S1P5; Edg-8; SPPR-1; SPPR-2 Summary The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008] Expression Biased expression in skin (RPKM 5.9), bone marrow (RPKM 5.0) and 10 other tissues See more Orthologs mouse all