NDP, Official Symbol NDPprovided by HGNC Official Full Name norrin cystine knot growth factor NDPprovided by HGNC Primary source HGNC:HGNC:7678 See related Ensembl:ENSG00000124479 MIM:300658; AllianceGenome:HGNC:7678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ND; EVR2; FEVR Summary This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009] Expression Biased expression in ovary (RPKM 17.5), endometrium (RPKM 9.6) and 3 other tissues See more Orthologs mouse all