RSPO1, Official Symbol RSPO1provided by HGNC Official Full Name R-spondin 1provided by HGNC Primary source HGNC:HGNC:21679 See related Ensembl:ENSG00000169218 MIM:609595; AllianceGenome:HGNC:21679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSPO; CRISTIN3 Summary This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Biased expression in endometrium (RPKM 16.2), skin (RPKM 2.3) and 5 other tissues See more Orthologs mouse all