GZMA, Official Symbol GZMAprovided by HGNC Official Full Name granzyme Aprovided by HGNC Primary source HGNC:HGNC:4708 See related Ensembl:ENSG00000145649 MIM:140050; AllianceGenome:HGNC:4708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HFSP; CTLA3 Summary Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 24.9), spleen (RPKM 21.4) and 20 other tissues See more Orthologs mouse all