TRIM63, Official Symbol TRIM63provided by HGNC Official Full Name tripartite motif containing 63provided by HGNC Primary source HGNC:HGNC:16007 See related Ensembl:ENSG00000158022 MIM:606131; AllianceGenome:HGNC:16007 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRF; SMRZ; MURF1; MURF2; RNF28 Summary This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012] Expression Biased expression in heart (RPKM 44.7) and esophagus (RPKM 2.8) See more Orthologs mouse all