RAPGEF6, Official Symbol RAPGEF6provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 6provided by HGNC Primary source HGNC:HGNC:20655 See related Ensembl:ENSG00000158987 MIM:610499; AllianceGenome:HGNC:20655 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAGEF2; PDZGEF2; KIA001LB; PDZ-GEF2; RA-GEF-2 Summary Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 9.8), appendix (RPKM 6.5) and 24 other tissues See more Orthologs mouse all