NUMA1, Official Symbol NUMA1provided by HGNC Official Full Name nuclear mitotic apparatus protein 1provided by HGNC Primary source HGNC:HGNC:8059 See related Ensembl:ENSG00000137497 MIM:164009; AllianceGenome:HGNC:8059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUMA; NMP-22 Summary This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] Expression Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues See more Orthologs mouse all