TSPAN8, Official Symbol TSPAN8provided by HGNC Official Full Name tetraspanin 8provided by HGNC Primary source HGNC:HGNC:11855 See related Ensembl:ENSG00000127324 MIM:600769; AllianceGenome:HGNC:11855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CO-029; TM4SF3 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 463.8), duodenum (RPKM 388.7) and 5 other tissues See more Orthologs mouse all