ULBP2, Official Symbol ULBP2provided by HGNC Official Full Name UL16 binding protein 2provided by HGNC Primary source HGNC:HGNC:14894 See related Ensembl:ENSG00000131015 MIM:605698; AllianceGenome:HGNC:14894 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha Summary This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015] Expression Biased expression in esophagus (RPKM 5.0), lung (RPKM 1.3) and 11 other tissues See more Orthologs all