OTUB2, Official Symbol OTUB2provided by HGNC Official Full Name OTU deubiquitinase, ubiquitin aldehyde binding 2provided by HGNC Primary source HGNC:HGNC:20351 See related Ensembl:ENSG00000089723 MIM:608338; AllianceGenome:HGNC:20351 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTB2; OTU2; C14orf137 Summary This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues See more Orthologs mouse all