CDC25B, Official Symbol CDC25Bprovided by HGNC Official Full Name cell division cycle 25Bprovided by HGNC Primary source HGNC:HGNC:1726 See related Ensembl:ENSG00000101224 MIM:116949; AllianceGenome:HGNC:1726 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues See more Orthologs mouse all