NKAP, Official Symbol NKAPprovided by HGNC Official Full Name NFKB activating proteinprovided by HGNC Primary source HGNC:HGNC:29873 See related Ensembl:ENSG00000101882 MIM:300766; AllianceGenome:HGNC:29873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRXSHD Summary This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010] Expression Ubiquitous expression in placenta (RPKM 6.5), ovary (RPKM 6.4) and 25 other tissues See more Orthologs mouse all