MRPL12, Official Symbol MRPL12provided by HGNC Official Full Name mitochondrial ribosomal protein L12provided by HGNC Primary source HGNC:HGNC:10378 See related Ensembl:ENSG00000262814 MIM:602375; AllianceGenome:HGNC:10378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 5c5-2; L12mt; MRPL7; bL12m; RPML12; MRPL7/L12; MRP-L31/34 Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 31.4), heart (RPKM 25.0) and 25 other tissues See more Orthologs mouse all