CARD10, Official Symbol CARD10provided by HGNC Official Full Name caspase recruitment domain family member 10provided by HGNC Primary source HGNC:HGNC:16422 See related Ensembl:ENSG00000100065 MIM:607209; AllianceGenome:HGNC:16422 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIMP1; IMD89; CARMA3 Summary The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008] Expression Broad expression in small intestine (RPKM 15.9), duodenum (RPKM 15.0) and 22 other tissues See more Orthologs mouse all