HPD, Official Symbol HPDprovided by HGNC Official Full Name 4-hydroxyphenylpyruvate dioxygenaseprovided by HGNC Primary source HGNC:HGNC:5147 See related Ensembl:ENSG00000158104 MIM:609695; AllianceGenome:HGNC:5147 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPD; HPPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE Summary The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] Expression Biased expression in liver (RPKM 441.7) and kidney (RPKM 174.9) See more Orthologs mouse all