ERVV-2, Official Symbol ERVV-2provided by HGNC Official Full Name endogenous retrovirus group V member 2, envelopeprovided by HGNC Primary source HGNC:HGNC:39051 See related Ensembl:ENSG00000268964 AllianceGenome:HGNC:39051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ENVV2; HERV-V2 Summary Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015] Expression Restricted expression toward placenta (RPKM 9.6) See more Orthologs all