CHRM3, Official Symbol CHRM3provided by HGNC Official Full Name cholinergic receptor muscarinic 3provided by HGNC Primary source HGNC:HGNC:1952 See related Ensembl:ENSG00000133019 MIM:118494; AllianceGenome:HGNC:1952 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HM3; PBS; EGBRS; m3AChR Summary The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016] Expression Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues See more Orthologs mouse all