NLRP12, Official Symbol NLRP12provided by HGNC Official Full Name NLR family pyrin domain containing 12provided by HGNC Primary source HGNC:HGNC:22938 See related Ensembl:ENSG00000142405 MIM:609648; AllianceGenome:HGNC:22938 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3 Summary This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] Expression Biased expression in bone marrow (RPKM 2.2), appendix (RPKM 1.2) and 7 other tissues See more Orthologs mouse all