NDE1, Official Symbol NDE1provided by HGNC Official Full Name nudE neurodevelopment protein 1provided by HGNC Primary source HGNC:HGNC:17619 See related Ensembl:ENSG00000072864 MIM:609449; AllianceGenome:HGNC:17619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDE; LIS4; MHAC; NUDE; NUDE1; HOM-TES-87 Summary This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] Expression Broad expression in esophagus (RPKM 68.2), prostate (RPKM 53.0) and 18 other tissues See more Orthologs mouse all