PDIA4, Official Symbol PDIA4provided by HGNC Official Full Name protein disulfide isomerase family A member 4provided by HGNC Primary source HGNC:HGNC:30167 See related Ensembl:ENSG00000155660 MIM:620018; AllianceGenome:HGNC:30167 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERP70; ERP72; ERp-72 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016] Expression Broad expression in thyroid (RPKM 166.5), liver (RPKM 67.6) and 24 other tissues See more Orthologs mouse all