GPRASP1, Official Symbol GPRASP1provided by HGNC Official Full Name G protein-coupled receptor associated sorting protein 1provided by HGNC Primary source HGNC:HGNC:24834 See related Ensembl:ENSG00000198932 MIM:300417; AllianceGenome:HGNC:24834 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GASP; GASP1; GASP-1 Summary This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010] Expression Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues See more Orthologs mouse all