TNNC1, Official Symbol TNNC1provided by HGNC Official Full Name troponin C1, slow skeletal and cardiac typeprovided by HGNC Primary source HGNC:HGNC:11943 See related Ensembl:ENSG00000114854 MIM:191040; AllianceGenome:HGNC:11943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNC; TN-C; TNNC; CMD1Z; CMH13 Summary Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008] Expression Restricted expression toward heart (RPKM 1964.8) See more Orthologs mouse all