TBX18, Official Symbol TBX18provided by HGNC Official Full Name T-box transcription factor 18provided by HGNC Primary source HGNC:HGNC:11595 See related Ensembl:ENSG00000112837 MIM:604613; AllianceGenome:HGNC:11595 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PUJO; CAKUT2 Summary This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012] Expression Broad expression in fat (RPKM 1.9), skin (RPKM 1.3) and 17 other tissues See more Orthologs mouse all