PTCH2, Official Symbol PTCH2provided by HGNC Official Full Name patched 2provided by HGNC Primary source HGNC:HGNC:9586 See related Ensembl:ENSG00000117425 MIM:603673; AllianceGenome:HGNC:9586 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTC2 Summary This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] Expression Biased expression in salivary gland (RPKM 12.5), testis (RPKM 11.4) and 10 other tissues See more Orthologs mouse all