DENND1B, Official Symbol DENND1Bprovided by HGNC Official Full Name DENN domain containing 1Bprovided by HGNC Primary source HGNC:HGNC:28404 See related Ensembl:ENSG00000213047 MIM:613292; AllianceGenome:HGNC:28404 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM31B; C1ORF18; C1orf218 Summary Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in colon (RPKM 1.5), thyroid (RPKM 1.4) and 25 other tissues See more Orthologs mouse all