SMPD4, Official Symbol SMPD4provided by HGNC Official Full Name sphingomyelin phosphodiesterase 4provided by HGNC Primary source HGNC:HGNC:32949 See related Ensembl:ENSG00000136699 MIM:610457; AllianceGenome:HGNC:32949 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SKNY; NET13; NEDMABA; NEDMEBA; NSMASE3; NSMASE-3 Summary The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in bone marrow (RPKM 16.4), testis (RPKM 14.6) and 25 other tissues See more Orthologs mouse all