CD177, Official Symbol CD177provided by HGNC Official Full Name CD177 moleculeprovided by HGNC Primary source HGNC:HGNC:30072 See related Ensembl:ENSG00000204936 MIM:162860; AllianceGenome:HGNC:30072 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP Summary This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014] Expression Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue See more Orthologs all