CENPA, Official Symbol CENPAprovided by HGNC Official Full Name centromere protein Aprovided by HGNC Primary source HGNC:HGNC:1851 See related Ensembl:ENSG00000115163 MIM:117139; AllianceGenome:HGNC:1851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CenH3; CENP-A Summary Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015] Expression Broad expression in lymph node (RPKM 4.5), appendix (RPKM 2.5) and 14 other tissues See more Orthologs mouse all