TMEFF2, Official Symbol TMEFF2provided by HGNC Official Full Name transmembrane protein with EGF like and two follistatin like domains 2provided by HGNC Primary source HGNC:HGNC:11867 See related Ensembl:ENSG00000144339 MIM:605734; AllianceGenome:HGNC:11867 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TR; HPP1; TPEF; TR-2; TENB2; CT120.2 Summary This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Expression Biased expression in prostate (RPKM 5.9), brain (RPKM 4.8) and 3 other tissues See more Orthologs mouse all