UGDH, Official Symbol UGDHprovided by HGNC Official Full Name UDP-glucose 6-dehydrogenaseprovided by HGNC Primary source HGNC:HGNC:12525 See related Ensembl:ENSG00000109814 MIM:603370; AllianceGenome:HGNC:12525 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDH; UGD; DEE84; EIEE84; UDPGDH; UDP-GlcDH Summary The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Expression Broad expression in colon (RPKM 31.0), liver (RPKM 26.9) and 23 other tissues See more Orthologs mouse all