COPS4, Official Symbol COPS4provided by HGNC Official Full Name COP9 signalosome subunit 4provided by HGNC Primary source HGNC:HGNC:16702 See related Ensembl:ENSG00000138663 MIM:616008; AllianceGenome:HGNC:16702 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSN4; SGN4 Summary This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.8) and 25 other tissues See more Orthologs mouse all