CLTRN, Official Symbol CLTRNprovided by HGNC Official Full Name collectrin, amino acid transport regulatorprovided by HGNC Primary source HGNC:HGNC:29437 See related Ensembl:ENSG00000147003 MIM:300631; AllianceGenome:HGNC:29437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NX17; NX-17; TMEM27 Summary This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013] Expression Biased expression in kidney (RPKM 116.5) and liver (RPKM 8.9) See more Orthologs mouse all