MYO9B, Official Symbol MYO9Bprovided by HGNC Official Full Name myosin IXBprovided by HGNC Primary source HGNC:HGNC:7609 See related Ensembl:ENSG00000099331 MIM:602129; AllianceGenome:HGNC:7609 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYR5; CELIAC4 Summary This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Broad expression in spleen (RPKM 30.6), bone marrow (RPKM 21.4) and 24 other tissues See more Orthologs mouse all