SORT1, Official Symbol SORT1provided by HGNC Official Full Name sortilin 1provided by HGNC Primary source HGNC:HGNC:11186 See related Ensembl:ENSG00000134243 MIM:602458; AllianceGenome:HGNC:11186 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NT3; Gp95; NTR3; LDLCQ6 Summary This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] Expression Broad expression in brain (RPKM 47.1), testis (RPKM 30.3) and 22 other tissues See more Orthologs mouse all