GRK1, Official Symbol GRK1provided by HGNC Official Full Name G protein-coupled receptor kinase 1provided by HGNC Primary source HGNC:HGNC:10013 See related Ensembl:ENSG00000185974 MIM:180381; AllianceGenome:HGNC:10013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RK; RHOK; GPRK1 Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008] Annotation information Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_027140.7 and the 3' end was annotated on NT_024498.13 in NCBI s Homo sapiens Annotation Release 106. [17 Jun 2014] Annotation category: suggests misassembly Expression Low expression observed in reference dataset See more Orthologs mouse all