CHAC1, Official Symbol CHAC1provided by HGNC Official Full Name ChaC glutathione specific gamma-glutamylcyclotransferase 1provided by HGNC Primary source HGNC:HGNC:28680 See related Ensembl:ENSG00000128965 MIM:614587; AllianceGenome:HGNC:28680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016] Expression Broad expression in esophagus (RPKM 2.7), pancreas (RPKM 2.0) and 19 other tissues See more Orthologs mouse all