MIB2, Official Symbol MIB2provided by HGNC Official Full Name MIB E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:30577 See related Ensembl:ENSG00000197530 MIM:611141; AllianceGenome:HGNC:30577 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZZZ5; ZZANK1 Summary The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues See more Orthologs mouse all