PVR, Official Symbol PVRprovided by HGNC Official Full Name PVR cell adhesion moleculeprovided by HGNC Primary source HGNC:HGNC:9705 See related Ensembl:ENSG00000073008 MIM:173850; AllianceGenome:HGNC:9705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PVS; HVED; CD155; NECL5; TAGE4; Necl-5 Summary The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues See more Orthologs all