DPP6, Official Symbol DPP6provided by HGNC Official Full Name dipeptidyl peptidase like 6provided by HGNC Primary source HGNC:HGNC:3010 See related Ensembl:ENSG00000130226 MIM:126141; AllianceGenome:HGNC:3010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VF2; DPL1; DPPX; MRD33 Summary This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Biased expression in brain (RPKM 22.2), endometrium (RPKM 11.9) and 5 other tissues See more Orthologs mouse all