UBD, Official Symbol UBDprovided by HGNC Official Full Name ubiquitin Dprovided by HGNC Primary source HGNC:HGNC:18795 See related Ensembl:ENSG00000213886 MIM:606050; AllianceGenome:HGNC:18795 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAT10; UBD-3; GABBR1 Summary This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. [provided by RefSeq, Aug 2017] Expression Biased expression in lymph node (RPKM 113.8), appendix (RPKM 64.9) and 10 other tissues See more Orthologs mouse all