IGFBP1, Official Symbol IGFBP1provided by HGNC Official Full Name insulin like growth factor binding protein 1provided by HGNC Primary source HGNC:HGNC:5469 See related Ensembl:ENSG00000146678 MIM:146730; AllianceGenome:HGNC:5469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1 Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017] Expression Biased expression in liver (RPKM 308.2), placenta (RPKM 135.7) and 1 other tissue See more Orthologs mouse all