NWD1, Official Symbol NWD1provided by HGNC Official Full Name NACHT and WD repeat domain containing 1provided by HGNC Primary source HGNC:HGNC:27619 See related Ensembl:ENSG00000188039 MIM:616250; AllianceGenome:HGNC:27619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] Expression Biased expression in prostate (RPKM 3.7), brain (RPKM 1.6) and 6 other tissues See more Orthologs mouse all