NPPA, Official Symbol NPPAprovided by HGNC Official Full Name natriuretic peptide Aprovided by HGNC Primary source HGNC:HGNC:7939 See related Ensembl:ENSG00000175206 MIM:108780; AllianceGenome:HGNC:7939 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF Summary The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015] Expression Restricted expression toward heart (RPKM 12159.5) See more Orthologs mouse all