CYP1A1, Official Symbol CYP1A1provided by HGNC Official Full Name cytochrome P450 family 1 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2595 See related Ensembl:ENSG00000140465 MIM:108330; AllianceGenome:HGNC:2595 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX Summary This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016] Expression Biased expression in urinary bladder (RPKM 40.8), liver (RPKM 18.0) and 1 other tissue See more Orthologs mouse all