CD3E, Official Symbol CD3Eprovided by HGNC Official Full Name CD3 epsilon subunit of T-cell receptor complexprovided by HGNC Primary source HGNC:HGNC:1674 See related Ensembl:ENSG00000198851 MIM:186830; AllianceGenome:HGNC:1674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3E; TCRE; IMD18; CD3epsilon Summary The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 92.6), appendix (RPKM 45.9) and 9 other tissues See more Orthologs mouse all