WT1, Official Symbol WT1provided by HGNC Official Full Name WT1 transcription factorprovided by HGNC Primary source HGNC:HGNC:12796 See related Ensembl:ENSG00000184937 MIM:607102; AllianceGenome:HGNC:12796 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2 Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] Expression Biased expression in endometrium (RPKM 27.6), testis (RPKM 17.6) and 4 other tissues See more Orthologs mouse all