CHFR, Official Symbol CHFRprovided by HGNC Official Full Name checkpoint with forkhead and ring finger domainsprovided by HGNC Primary source HGNC:HGNC:20455 See related Ensembl:ENSG00000072609 MIM:605209; AllianceGenome:HGNC:20455 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF116; RNF196 Summary This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in testis (RPKM 9.9), spleen (RPKM 8.8) and 25 other tissues See more Orthologs mouse all