CYBA, Official Symbol CYBAprovided by HGNC Official Full Name cytochrome b-245 alpha chainprovided by HGNC Primary source HGNC:HGNC:2577 See related Ensembl:ENSG00000051523 MIM:608508; AllianceGenome:HGNC:2577 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGD4; p22-PHOX Summary Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 72.4), spleen (RPKM 55.1) and 18 other tissues See more Orthologs mouse all