SP110, Official Symbol SP110provided by HGNC Official Full Name SP110 nuclear body proteinprovided by HGNC Primary source HGNC:HGNC:5401 See related Ensembl:ENSG00000135899 MIM:604457; AllianceGenome:HGNC:5401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPR1; VODI; IFI41; IFI75 Summary The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 11.2), lymph node (RPKM 10.7) and 24 other tissues See more Orthologs all