KCNH1, Official Symbol KCNH1provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 1provided by HGNC Primary source HGNC:HGNC:6250 See related Ensembl:ENSG00000143473 MIM:603305; AllianceGenome:HGNC:6250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAG; EAG1; ZLS1; hEAG; TMBTS; h-eag; hEAG1; Kv10.1; K(V)10.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.3), adrenal (RPKM 0.4) and 3 other tissues See more Orthologs mouse all