FADD, Official Symbol FADDprovided by HGNC Official Full Name Fas associated via death domainprovided by HGNC Primary source HGNC:HGNC:3573 See related Ensembl:ENSG00000168040 MIM:602457; AllianceGenome:HGNC:3573 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIG3; IMD90; MORT1 Summary The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues See more Orthologs mouse all