PDLIM2, Official Symbol PDLIM2provided by HGNC Official Full Name PDZ and LIM domain 2provided by HGNC Primary source HGNC:HGNC:13992 See related Ensembl:ENSG00000120913 MIM:609722; AllianceGenome:HGNC:13992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLIM; MYSTIQUE Summary This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] Expression Broad expression in spleen (RPKM 22.4), lung (RPKM 9.5) and 21 other tissues See more Orthologs mouse all