TNFRSF11B, Official Symbol TNFRSF11Bprovided by HGNC Official Full Name TNF receptor superfamily member 11bprovided by HGNC Primary source HGNC:HGNC:11909 See related Ensembl:ENSG00000164761 MIM:602643; AllianceGenome:HGNC:11909 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPG; TR1; OCIF; PDB5 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 62.5), kidney (RPKM 16.2) and 7 other tissues See more Orthologs mouse all