COX8A, Official Symbol COX8Aprovided by HGNC Official Full Name cytochrome c oxidase subunit 8Aprovided by HGNC Primary source HGNC:HGNC:2294 See related Ensembl:ENSG00000176340 MIM:123870; AllianceGenome:HGNC:2294 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COX; COX8; VIII; COX8L; COX8-2; VIII-L; MC4DN15 Summary The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 159.8), colon (RPKM 143.7) and 25 other tissues See more Orthologs mouse all