UBQLN2, Official Symbol UBQLN2provided by HGNC Official Full Name ubiquilin 2provided by HGNC Primary source HGNC:HGNC:12509 See related Ensembl:ENSG00000188021 MIM:300264; AllianceGenome:HGNC:12509 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157 Summary This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009] Orthologs mouse all