ZBTB42, Official Symbol ZBTB42provided by HGNC Official Full Name zinc finger and BTB domain containing 42provided by HGNC Primary source HGNC:HGNC:32550 See related Ensembl:ENSG00000179627 MIM:613915; AllianceGenome:HGNC:32550 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCCS6; ZNF925 Summary The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015] Expression Ubiquitous expression in prostate (RPKM 4.4), lung (RPKM 3.3) and 24 other tissues See more Orthologs mouse all