DDOST, Official Symbol DDOSTprovided by HGNC Official Full Name dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunitprovided by HGNC Primary source HGNC:HGNC:2728 See related Ensembl:ENSG00000244038 MIM:602202; AllianceGenome:HGNC:2728 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OST; WBP1; AGER1; CDG1R; GATD6; OST48; OKSWcl45 Summary This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 112.6), placenta (RPKM 100.3) and 25 other tissues See more Orthologs mouse all