GNA11, Official Symbol GNA11provided by HGNC Official Full Name G protein subunit alpha 11provided by HGNC Primary source HGNC:HGNC:4379 See related Ensembl:ENSG00000088256 MIM:139313; AllianceGenome:HGNC:4379 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBH; FBH2; FHH2; HG1K; HHC2; GNA-11; HYPOC2 Summary The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013] Expression Broad expression in small intestine (RPKM 57.6), duodenum (RPKM 46.4) and 23 other tissues See more Orthologs mouse all