CHRNA3, Official Symbol CHRNA3provided by HGNC Official Full Name cholinergic receptor nicotinic alpha 3 subunitprovided by HGNC Primary source HGNC:HGNC:1957 See related Ensembl:ENSG00000080644 MIM:118503; AllianceGenome:HGNC:1957 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LNCR2; PAOD2; BAIPRCK; NACHRA3 Summary This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009] Expression Biased expression in adrenal (RPKM 16.5), appendix (RPKM 2.4) and 2 other tissues See more Orthologs mouse all