WASL, Official Symbol WASLprovided by HGNC Official Full Name WASP like actin nucleation promoting factorprovided by HGNC Primary source HGNC:HGNC:12735 See related Ensembl:ENSG00000106299 MIM:605056; AllianceGenome:HGNC:12735 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NWASP; WASPB; N-WASP Summary This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in colon (RPKM 25.7), thyroid (RPKM 23.4) and 25 other tissues See more Orthologs mouse all