CLDN10, Official Symbol CLDN10provided by HGNC Official Full Name claudin 10provided by HGNC Primary source HGNC:HGNC:2033 See related Ensembl:ENSG00000134873 MIM:617579; AllianceGenome:HGNC:2033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSPL; HELIX; OSP-L; CPETRL3 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010] Expression Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues See more Orthologs mouse all