MLKL, Official Symbol MLKLprovided by HGNC Official Full Name mixed lineage kinase domain like pseudokinaseprovided by HGNC Primary source HGNC:HGNC:26617 See related Ensembl:ENSG00000168404 MIM:615153; AllianceGenome:HGNC:26617 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hMLKL Summary This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] Expression Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 10.4) and 23 other tissues See more Orthologs mouse all