PTGS2, Official Symbol PTGS2provided by HGNC Official Full Name prostaglandin-endoperoxide synthase 2provided by HGNC Primary source HGNC:HGNC:9605 See related Ensembl:ENSG00000073756 MIM:600262; AllianceGenome:HGNC:9605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] Expression Biased expression in bone marrow (RPKM 59.3), urinary bladder (RPKM 41.1) and 11 other tissues See more Orthologs mouse all