CNTFR, Official Symbol CNTFRprovided by HGNC Official Full Name ciliary neurotrophic factor receptorprovided by HGNC Primary source HGNC:HGNC:2170 See related Ensembl:ENSG00000122756 MIM:118946; AllianceGenome:HGNC:2170 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011] Expression Biased expression in fat (RPKM 23.5), brain (RPKM 9.3) and 10 other tissues See more Orthologs mouse all