RGS3, Official Symbol RGS3provided by HGNC Official Full Name regulator of G protein signaling 3provided by HGNC Primary source HGNC:HGNC:9999 See related Ensembl:ENSG00000138835 MIM:602189; AllianceGenome:HGNC:9999 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2PA; RGP3 Summary This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in heart (RPKM 8.0), fat (RPKM 4.2) and 24 other tissues See more Orthologs mouse all