EDNRB, Official Symbol EDNRBprovided by HGNC Official Full Name endothelin receptor type Bprovided by HGNC Primary source HGNC:HGNC:3180 See related Ensembl:ENSG00000136160 MIM:131244; AllianceGenome:HGNC:3180 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2 Summary The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Broad expression in placenta (RPKM 49.8), lung (RPKM 38.6) and 21 other tissues See more Orthologs mouse all