HLA-DOB, Official Symbol HLA-DOBprovided by HGNC Official Full Name major histocompatibility complex, class II, DO betaprovided by HGNC Primary source HGNC:HGNC:4937 See related Ensembl:ENSG00000241106 MIM:600629; AllianceGenome:HGNC:4937 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOB; HLA_DOB Summary HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 34.2), spleen (RPKM 22.4) and 9 other tissues See more Orthologs mouse all