HSH2D, Official Symbol HSH2Dprovided by HGNC Official Full Name hematopoietic SH2 domain containingprovided by HGNC Primary source HGNC:HGNC:24920 See related Ensembl:ENSG00000196684 MIM:608349; AllianceGenome:HGNC:24920 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALX; HSH2 Summary T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008] Expression Biased expression in bone marrow (RPKM 13.9), spleen (RPKM 9.5) and 11 other tissues See more Orthologs mouse all