ITGB1BP2, Official Symbol ITGB1BP2provided by HGNC Official Full Name integrin subunit beta 1 binding protein 2provided by HGNC Primary source HGNC:HGNC:6154 See related Ensembl:ENSG00000147166 MIM:300332; AllianceGenome:HGNC:6154 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHORDC3; ITGB1BP; MELUSIN; MSTP015 Summary This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017] Expression Biased expression in heart (RPKM 22.0), prostate (RPKM 2.3) and 3 other tissues See more Orthologs mouse all