STK36, Official Symbol STK36provided by HGNC Official Full Name serine/threonine kinase 36provided by HGNC Primary source HGNC:HGNC:17209 See related Ensembl:ENSG00000163482 MIM:607652; AllianceGenome:HGNC:17209 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FU; CILD46 Summary This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues See more Orthologs mouse all