CHRFAM7A, Official Symbol CHRFAM7Aprovided by HGNC Official Full Name CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusionprovided by HGNC Primary source HGNC:HGNC:15781 See related Ensembl:ENSG00000166664 MIM:609756; AllianceGenome:HGNC:15781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D-10; CHRNA7; NACHRA7; CHRNA7-DR1 Summary The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 4.3), small intestine (RPKM 4.0) and 19 other tissues See more Orthologs all