ADORA1, Official Symbol ADORA1provided by HGNC Official Full Name adenosine A1 receptorprovided by HGNC Primary source HGNC:HGNC:262 See related Ensembl:ENSG00000163485 MIM:102775; AllianceGenome:HGNC:262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDC7 Summary The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more Orthologs mouse all