TFAM, Official Symbol TFAMprovided by HGNC Official Full Name transcription factor A, mitochondrialprovided by HGNC Primary source HGNC:HGNC:11741 See related Ensembl:ENSG00000108064 MIM:600438; AllianceGenome:HGNC:11741 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15 Summary This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in testis (RPKM 11.2), thyroid (RPKM 9.8) and 25 other tissues See more Orthologs mouse all