AMBRA1, Official Symbol AMBRA1provided by HGNC Official Full Name autophagy and beclin 1 regulator 1provided by HGNC Primary source HGNC:HGNC:25990 See related Ensembl:ENSG00000110497 MIM:611359; AllianceGenome:HGNC:25990 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCAF3; WDR94 Summary Enables GTPase binding activity and ubiquitin protein ligase binding activity. Involved in macroautophagy; positive regulation of phosphatidylinositol 3-kinase activity; and response to mitochondrial depolarisation. Located in cytosol. Colocalizes with mitochondrion. Biomarker of multiple system atrophy. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 5.9), brain (RPKM 5.4) and 25 other tissues See more Orthologs mouse all