KCND3, Official Symbol KCND3provided by HGNC Official Full Name potassium voltage-gated channel subfamily D member 3provided by HGNC Primary source HGNC:HGNC:6239 See related Ensembl:ENSG00000171385 MIM:605411; AllianceGenome:HGNC:6239 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 4.9), prostate (RPKM 2.7) and 17 other tissues See more Orthologs mouse all