LRRFIP2, Official Symbol LRRFIP2provided by HGNC Official Full Name LRR binding FLII interacting protein 2provided by HGNC Primary source HGNC:HGNC:6703 See related Ensembl:ENSG00000093167 MIM:614043; AllianceGenome:HGNC:6703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUFI-2 Summary The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues See more Orthologs mouse all