BCL11A, Official Symbol BCL11Aprovided by HGNC Official Full Name BCL11 transcription factor Aprovided by HGNC Primary source HGNC:HGNC:13221 See related Ensembl:ENSG00000119866 MIM:606557; AllianceGenome:HGNC:13221 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EVI9; CTIP1; DILOS; ZNF856; HBFQTL5; SMARCM1 Summary This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Broad expression in skin (RPKM 2.8), lymph node (RPKM 2.2) and 17 other tissues See more Orthologs mouse all