LTC4S, Official Symbol LTC4Sprovided by HGNC Official Full Name leukotriene C4 synthaseprovided by HGNC Primary source HGNC:HGNC:6719 See related Ensembl:ENSG00000213316 MIM:246530; AllianceGenome:HGNC:6719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 3.3), lung (RPKM 2.5) and 23 other tissues See more Orthologs mouse all