GEN1, Official Symbol GEN1provided by HGNC Official Full Name GEN1 Holliday junction 5' flap endonucleaseprovided by HGNC Primary source HGNC:HGNC:26881 See related Ensembl:ENSG00000178295 MIM:612449; AllianceGenome:HGNC:26881 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gen Summary This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] Expression Broad expression in lymph node (RPKM 4.2), testis (RPKM 3.9) and 25 other tissues See more Orthologs mouse all