PCK1, Official Symbol PCK1provided by HGNC Official Full Name phosphoenolpyruvate carboxykinase 1provided by HGNC Primary source HGNC:HGNC:8724 See related Ensembl:ENSG00000124253 MIM:614168; AllianceGenome:HGNC:8724 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCKDC; PEPCK1; PEPCKC; PEPCK-C Summary This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 471.7), kidney (RPKM 448.1) and 4 other tissues See more Orthologs mouse all