MMP3, Official Symbol MMP3provided by HGNC Official Full Name matrix metallopeptidase 3provided by HGNC Primary source HGNC:HGNC:7173 See related Ensembl:ENSG00000149968 MIM:185250; AllianceGenome:HGNC:7173 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SL-1; STMY; STR1; CHDS6; MMP-3; STMY1 Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 37.5), appendix (RPKM 12.3) and 1 other tissue See more Orthologs all