CRHBP, Official Symbol CRHBPprovided by HGNC Official Full Name corticotropin releasing hormone binding proteinprovided by HGNC Primary source HGNC:HGNC:2356 See related Ensembl:ENSG00000145708 MIM:122559; AllianceGenome:HGNC:2356 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRFBP; CRF-BP Summary Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues See more Orthologs mouse all