PAK3, Official Symbol PAK3provided by HGNC Official Full Name p21 (RAC1) activated kinase 3provided by HGNC Primary source HGNC:HGNC:8592 See related Ensembl:ENSG00000077264 MIM:300142; AllianceGenome:HGNC:8592 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK Summary The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017] Expression Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more Orthologs mouse all