SH2B2, Official Symbol SH2B2provided by HGNC Official Full Name SH2B adaptor protein 2provided by HGNC Primary source HGNC:HGNC:17381 See related Ensembl:ENSG00000160999 MIM:605300; AllianceGenome:HGNC:17381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APS Summary The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009] Expression Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues See more Orthologs mouse all