IL12A, Official Symbol IL12Aprovided by HGNC Official Full Name interleukin 12Aprovided by HGNC Primary source HGNC:HGNC:5969 See related Ensembl:ENSG00000168811 MIM:161560; AllianceGenome:HGNC:5969 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P35; CLMF; NFSK; NKSF1; IL-12A Summary This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues See more Orthologs mouse all