XPC, Official Symbol XPCprovided by HGNC Official Full Name XPC complex subunit, DNA damage recognition and repair factorprovided by HGNC Primary source HGNC:HGNC:12816 See related Ensembl:ENSG00000154767 MIM:613208; AllianceGenome:HGNC:12816 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XP3; RAD4; XPCC; p125 Summary The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in ovary (RPKM 17.1), kidney (RPKM 15.8) and 25 other tissues See more Orthologs mouse all