MMP16, Official Symbol MMP16provided by HGNC Official Full Name matrix metallopeptidase 16provided by HGNC Primary source HGNC:HGNC:7162 See related Ensembl:ENSG00000156103 MIM:602262; AllianceGenome:HGNC:7162 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010] Expression Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues See more Orthologs mouse all