AGAP3, Official Symbol AGAP3provided by HGNC Official Full Name ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by HGNC Primary source HGNC:HGNC:16923 See related Ensembl:ENSG00000133612 MIM:616813; AllianceGenome:HGNC:16923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3 Summary This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in brain (RPKM 17.1), lung (RPKM 9.1) and 25 other tissues See more Orthologs mouse all