CYP26A1, Official Symbol CYP26A1provided by HGNC Official Full Name cytochrome P450 family 26 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2603 See related Ensembl:ENSG00000095596 MIM:602239; AllianceGenome:HGNC:2603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP26; CYP26; P450RAI; P450RAI1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 15.5) See more Orthologs mouse all