EPHX1, Official Symbol EPHX1provided by HGNC Official Full Name epoxide hydrolase 1provided by HGNC Primary source HGNC:HGNC:3401 See related Ensembl:ENSG00000143819 MIM:132810; AllianceGenome:HGNC:3401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEH; EPHX; EPOX; HYL1 Summary Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008] Expression Broad expression in liver (RPKM 307.4), adrenal (RPKM 287.9) and 19 other tissues See more Orthologs mouse all