CDH11, Official Symbol CDH11provided by HGNC Official Full Name cadherin 11provided by HGNC Primary source HGNC:HGNC:1750 See related Ensembl:ENSG00000140937 MIM:600023; AllianceGenome:HGNC:1750 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OB; ESWS; CAD11; CDHOB; OSF-4; TBHS2 Summary This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 46.8), placenta (RPKM 33.6) and 14 other tissues See more Orthologs mouse all