ADAMTS15, Official Symbol ADAMTS15provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 15provided by HGNC Primary source HGNC:HGNC:16305 See related Ensembl:ENSG00000166106 MIM:607509; AllianceGenome:HGNC:16305 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016] Expression Biased expression in fat (RPKM 10.9), placenta (RPKM 8.5) and 13 other tissues See more Orthologs mouse all