HOXD3, Official Symbol HOXD3provided by HGNC Official Full Name homeobox D3provided by HGNC Primary source HGNC:HGNC:5137 See related Ensembl:ENSG00000128652 MIM:142980; AllianceGenome:HGNC:5137 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX4; HOX1D; HOX4A; Hox-4.1 Summary This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 1.9), endometrium (RPKM 1.4) and 11 other tissues See more Orthologs mouse all