DAO, Official Symbol DAOprovided by HGNC Official Full Name D-amino acid oxidaseprovided by HGNC Primary source HGNC:HGNC:2671 See related Ensembl:ENSG00000110887 MIM:124050; AllianceGenome:HGNC:2671 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAAO; OXDA; DAMOX Summary This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1) See more Orthologs mouse all