SLC26A3, Official Symbol SLC26A3provided by HGNC Official Full Name solute carrier family 26 member 3provided by HGNC Primary source HGNC:HGNC:3018 See related Ensembl:ENSG00000091138 MIM:126650; AllianceGenome:HGNC:3018 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLD; DRA Summary The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] Expression Biased expression in colon (RPKM 709.1), duodenum (RPKM 299.0) and 1 other tissue See more Orthologs mouse all