LMX1B, Official Symbol LMX1Bprovided by HGNC Official Full Name LIM homeobox transcription factor 1 betaprovided by HGNC Primary source HGNC:HGNC:6654 See related Ensembl:ENSG00000136944 MIM:602575; AllianceGenome:HGNC:6654 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPS1; FSGS10; LMX1.2 Summary This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Biased expression in salivary gland (RPKM 1.8), kidney (RPKM 0.4) and 3 other tissues See more Orthologs mouse all