ERCC3, Official Symbol ERCC3provided by HGNC Official Full Name ERCC excision repair 3, TFIIH core complex helicase subunitprovided by HGNC Primary source HGNC:HGNC:3435 See related Ensembl:ENSG00000163161 MIM:133510; AllianceGenome:HGNC:3435 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XPB; BTF2; Ssl2; TTD2; GTF2H; RAD25; TFIIH Summary This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in testis (RPKM 20.2), lymph node (RPKM 14.6) and 25 other tissues See more Orthologs mouse all