MAPK8IP1, Official Symbol MAPK8IP1provided by HGNC Official Full Name mitogen-activated protein kinase 8 interacting protein 1provided by HGNC Primary source HGNC:HGNC:6882 See related Ensembl:ENSG00000121653 MIM:604641; AllianceGenome:HGNC:6882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IB1; JIP1; JIP-1; PRKM8IP Summary This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011] Expression Biased expression in brain (RPKM 54.8), testis (RPKM 11.7) and 5 other tissues See more Orthologs mouse all