BRAT1, Official Symbol BRAT1provided by HGNC Official Full Name BRCA1 associated ATM activator 1provided by HGNC Primary source HGNC:HGNC:21701 See related Ensembl:ENSG00000106009 MIM:614506; AllianceGenome:HGNC:21701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAAT1; RMFSL; NEDCAS; C7orf27 Summary The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in testis (RPKM 8.5), spleen (RPKM 7.2) and 25 other tissues See more Orthologs mouse all