CDK1, Official Symbol CDK1provided by HGNC Official Full Name cyclin dependent kinase 1provided by HGNC Primary source HGNC:HGNC:1722 See related Ensembl:ENSG00000170312 MIM:116940; AllianceGenome:HGNC:1722 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC2; CDC28A; P34CDC2 Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023] Expression Broad expression in lymph node (RPKM 12.8), bone marrow (RPKM 12.8) and 18 other tissues See more Orthologs mouse all