HLA-DMA, Official Symbol HLA-DMAprovided by HGNC Official Full Name major histocompatibility complex, class II, DM alphaprovided by HGNC Primary source HGNC:HGNC:4934 See related Ensembl:ENSG00000204257 MIM:142855; AllianceGenome:HGNC:4934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DMA; HLADM; RING6; D6S222E Summary HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 124.3), lung (RPKM 102.4) and 24 other tissues See more Orthologs mouse all