CELSR2, Official Symbol CELSR2provided by HGNC Official Full Name cadherin EGF LAG seven-pass G-type receptor 2provided by HGNC Primary source HGNC:HGNC:3231 See related Ensembl:ENSG00000143126 MIM:604265; AllianceGenome:HGNC:3231 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1 Summary The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 19.7), skin (RPKM 15.6) and 10 other tissues See more Orthologs mouse all