ADAMTS3, Official Symbol ADAMTS3provided by HGNC Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif 3provided by HGNC Primary source HGNC:HGNC:219 See related Ensembl:ENSG00000156140 MIM:605011; AllianceGenome:HGNC:219 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HKLLS3; ADAMTS-4 Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016] Expression Broad expression in testis (RPKM 1.4), ovary (RPKM 1.0) and 22 other tissues See more Orthologs mouse all