CRHR2, Official Symbol CRHR2provided by HGNC Official Full Name corticotropin releasing hormone receptor 2provided by HGNC Primary source HGNC:HGNC:2358 See related Ensembl:ENSG00000106113 MIM:602034; AllianceGenome:HGNC:2358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRF2; CRFR2; CRF-RB; HM-CRF Summary The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all