SETD1A, Official Symbol SETD1Aprovided by HGNC Official Full Name SET domain containing 1A, histone lysine methyltransferaseprovided by HGNC Primary source HGNC:HGNC:29010 See related Ensembl:ENSG00000099381 MIM:611052; AllianceGenome:HGNC:29010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Set1; EPEDD; EPEO2; KMT2F; Set1A; NEDSID Summary The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in testis (RPKM 10.6), bone marrow (RPKM 6.2) and 25 other tissues See more Orthologs mouse all