POLK, Official Symbol POLKprovided by HGNC Official Full Name DNA polymerase kappaprovided by HGNC Primary source HGNC:HGNC:9183 See related Ensembl:ENSG00000122008 MIM:605650; AllianceGenome:HGNC:9183 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DINP; POLQ; DINB1 Summary This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in thyroid (RPKM 6.4), testis (RPKM 4.9) and 25 other tissues See more Orthologs mouse all