DNASE1L3, Official Symbol DNASE1L3provided by HGNC Official Full Name deoxyribonuclease 1 like 3provided by HGNC Primary source HGNC:HGNC:2959 See related Ensembl:ENSG00000163687 MIM:602244; AllianceGenome:HGNC:2959 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSD; DHP2; SLEB16; DNAS1L3 Summary This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] Expression Biased expression in spleen (RPKM 118.4), liver (RPKM 61.9) and 11 other tissues See more Orthologs mouse all