PES1, Official Symbol PES1provided by HGNC Official Full Name pescadillo ribosomal biogenesis factor 1provided by HGNC Primary source HGNC:HGNC:8848 See related Ensembl:ENSG00000100029 MIM:605819; AllianceGenome:HGNC:8848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PES; NOP7 Summary This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in testis (RPKM 9.0), ovary (RPKM 7.8) and 25 other tissues See more Orthologs mouse all