GZMK, Official Symbol GZMKprovided by HGNC Official Full Name granzyme Kprovided by HGNC Primary source HGNC:HGNC:4711 See related Ensembl:ENSG00000113088 MIM:600784; AllianceGenome:HGNC:4711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRYP2 Summary This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 65.9), spleen (RPKM 22.6) and 7 other tissues See more Orthologs mouse all