NR1D1, Official Symbol NR1D1provided by HGNC Official Full Name nuclear receptor subfamily 1 group D member 1provided by HGNC Primary source HGNC:HGNC:7962 See related Ensembl:ENSG00000126368 MIM:602408; AllianceGenome:HGNC:7962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAR1; hRev; THRA1; THRAL; ear-1; REVERBA; REVERBalpha Summary This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in ovary (RPKM 21.5), brain (RPKM 21.4) and 24 other tissues See more Orthologs mouse all