FBXW12, Official Symbol FBXW12provided by HGNC Official Full Name F-box and WD repeat domain containing 12provided by HGNC Primary source HGNC:HGNC:20729 See related Ensembl:ENSG00000164049 MIM:609075; AllianceGenome:HGNC:20729 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBW12; FBXO12; FBXO35 Summary Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] Expression Low expression observed in reference dataset See more Orthologs all