CORO7, Official Symbol CORO7provided by HGNC Official Full Name coronin 7provided by HGNC Primary source HGNC:HGNC:26161 See related Ensembl:ENSG00000262246 MIM:611668; AllianceGenome:HGNC:26161 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRN7; POD1; 0610011B16Rik Summary This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016] Expression Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues See more Orthologs mouse all