UNC5B, Official Symbol UNC5Bprovided by HGNC Official Full Name unc-5 netrin receptor Bprovided by HGNC Primary source HGNC:HGNC:12568 See related Ensembl:ENSG00000107731 MIM:607870; AllianceGenome:HGNC:12568 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC5H2; p53RDL1 Summary This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in brain (RPKM 4.8), gall bladder (RPKM 4.7) and 24 other tissues See more Orthologs mouse all