ABI3, Official Symbol ABI3provided by HGNC Official Full Name ABI family member 3provided by HGNC Primary source HGNC:HGNC:29859 See related Ensembl:ENSG00000108798 MIM:606363; AllianceGenome:HGNC:29859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NESH; SSH3BP3 Summary This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Broad expression in spleen (RPKM 23.3), lymph node (RPKM 10.1) and 21 other tissues See more Orthologs mouse all