POLD3, Official Symbol POLD3provided by HGNC Official Full Name DNA polymerase delta 3, accessory subunitprovided by HGNC Primary source HGNC:HGNC:20932 See related Ensembl:ENSG00000077514 MIM:611415; AllianceGenome:HGNC:20932 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P66; P68; PPP1R128 Summary This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in testis (RPKM 7.5), colon (RPKM 6.2) and 25 other tissues See more Orthologs mouse all