GCHFR, Official Symbol GCHFRprovided by HGNC Official Full Name GTP cyclohydrolase I feedback regulatorprovided by HGNC Primary source HGNC:HGNC:4194 See related Ensembl:ENSG00000137880 MIM:602437; AllianceGenome:HGNC:4194 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P35; GFRP; HsT16933 Summary GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 32.0), small intestine (RPKM 26.3) and 23 other tissues See more Orthologs mouse all