PYGB, Official Symbol PYGBprovided by HGNC Official Full Name glycogen phosphorylase Bprovided by HGNC Primary source HGNC:HGNC:9723 See related Ensembl:ENSG00000100994 MIM:138550; AllianceGenome:HGNC:9723 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPBB Summary The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 67.8), heart (RPKM 66.8) and 23 other tissues See more Orthologs mouse all