ZMPSTE24, Official Symbol ZMPSTE24provided by HGNC Official Full Name zinc metallopeptidase STE24provided by HGNC Primary source HGNC:HGNC:12877 See related Ensembl:ENSG00000084073 MIM:606480; AllianceGenome:HGNC:12877 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HGPS; PRO1; FACE1; RSDM1; STE24; FACE-1; Ste24p Summary This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 22.0), gall bladder (RPKM 20.0) and 25 other tissues See more Orthologs mouse all