FMO4, Official Symbol FMO4provided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 4provided by HGNC Primary source HGNC:HGNC:3772 See related Ensembl:ENSG00000076258 MIM:136131; AllianceGenome:HGNC:3772 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMO2 Summary Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in kidney (RPKM 11.6), liver (RPKM 9.8) and 23 other tissues See more Orthologs mouse all