VEGFB, Official Symbol VEGFBprovided by HGNC Official Full Name vascular endothelial growth factor Bprovided by HGNC Primary source HGNC:HGNC:12681 See related Ensembl:ENSG00000173511 MIM:601398; AllianceGenome:HGNC:12681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VRF; VEGFL Summary This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011] Expression Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues See more Orthologs mouse all