LONP2, Official Symbol LONP2provided by HGNC Official Full Name lon peptidase 2, peroxisomalprovided by HGNC Primary source HGNC:HGNC:20598 See related Ensembl:ENSG00000102910 MIM:617774; AllianceGenome:HGNC:20598 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LONP; PLON; LONPL; PSLON Summary In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in thyroid (RPKM 23.1), liver (RPKM 21.0) and 25 other tissues See more Orthologs mouse all