M6PR, Official Symbol M6PRprovided by HGNC Official Full Name mannose-6-phosphate receptor, cation dependentprovided by HGNC Primary source HGNC:HGNC:6752 See related Ensembl:ENSG00000003056 MIM:154540; AllianceGenome:HGNC:6752 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR Summary This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011] Expression Ubiquitous expression in appendix (RPKM 59.8), lymph node (RPKM 57.5) and 25 other tissues See more Orthologs mouse all