HIGD2A, Official Symbol HIGD2Aprovided by HGNC Official Full Name HIG1 hypoxia inducible domain family member 2Aprovided by HGNC Primary source HGNC:HGNC:28311 See related Ensembl:ENSG00000146066 AllianceGenome:HGNC:28311 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCF1b Summary The protein encoded by this gene is a subunit of the cytochrome c oxidase complex (complex IV), which is the terminal enzyme in the mitochondrial respiratory chain. The encoded protein is an inner mitochondrial membrane protein and is a functional ortholog of the yeast respiratory supercomplex factor 1 (Rcf1). In mouse, the orthologous protein enhances cell survival under conditions of hypoxia. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in heart (RPKM 70.3), colon (RPKM 67.0) and 25 other tissues See more Orthologs mouse all