BIRC2, Official Symbol BIRC2provided by HGNC Official Full Name baculoviral IAP repeat containing 2provided by HGNC Primary source HGNC:HGNC:590 See related Ensembl:ENSG00000110330 MIM:601712; AllianceGenome:HGNC:590 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1 Summary The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in lymph node (RPKM 16.6), gall bladder (RPKM 15.7) and 25 other tissues See more Orthologs mouse all