EIF4EBP1, Official Symbol EIF4EBP1provided by HGNC Official Full Name eukaryotic translation initiation factor 4E binding protein 1provided by HGNC Primary source HGNC:HGNC:3288 See related Ensembl:ENSG00000187840 MIM:602223; AllianceGenome:HGNC:3288 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BP-1; 4EBP1; 4E-BP1; PHAS-I Summary This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in salivary gland (RPKM 30.3), fat (RPKM 26.3) and 25 other tissues See more Orthologs mouse all