ESPL1, Official Symbol ESPL1provided by HGNC Official Full Name extra spindle pole bodies like 1, separaseprovided by HGNC Primary source HGNC:HGNC:16856 See related Ensembl:ENSG00000135476 MIM:604143; AllianceGenome:HGNC:16856 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESP1; SEPA Summary Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010] Expression Biased expression in esophagus (RPKM 7.6), testis (RPKM 5.7) and 12 other tissues See more Orthologs mouse all