LTA, Official Symbol LTAprovided by HGNC Official Full Name lymphotoxin alphaprovided by HGNC Primary source HGNC:HGNC:6709 See related Ensembl:ENSG00000226979 MIM:153440; AllianceGenome:HGNC:6709 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LT; TNFB; TNFSF1; TNLG1E Summary The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Biased expression in lymph node (RPKM 3.5), appendix (RPKM 1.7) and 7 other tissues See more Orthologs mouse all