REV3L, Official Symbol REV3Lprovided by HGNC Official Full Name REV3 like, DNA directed polymerase zeta catalytic subunitprovided by HGNC Primary source HGNC:HGNC:9968 See related Ensembl:ENSG00000009413 MIM:602776; AllianceGenome:HGNC:9968 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POLZ; REV3 Summary The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in endometrium (RPKM 7.3), testis (RPKM 3.7) and 25 other tissues See more Orthologs mouse all