MARCHF4, Official Symbol MARCHF4provided by HGNC Official Full Name membrane associated ring-CH-type finger 4provided by HGNC Primary source HGNC:HGNC:29269 See related Ensembl:ENSG00000144583 MIM:608208; AllianceGenome:HGNC:29269 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH4; RNF174; MARCH-IV Summary MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010] Expression Biased expression in brain (RPKM 3.9), stomach (RPKM 1.1) and 2 other tissues See more Orthologs mouse all