SLC10A2, Official Symbol SLC10A2provided by HGNC Official Full Name solute carrier family 10 member 2provided by HGNC Primary source HGNC:HGNC:10906 See related Ensembl:ENSG00000125255 MIM:601295; AllianceGenome:HGNC:10906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASBT; IBAT; ISBT; PBAM; NTCP2; PBAM1 Summary This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010] Expression Biased expression in small intestine (RPKM 25.8), duodenum (RPKM 11.2) and 1 other tissue See more Orthologs mouse all