SPINK5, Official Symbol SPINK5provided by HGNC Official Full Name serine peptidase inhibitor Kazal type 5provided by HGNC Primary source HGNC:HGNC:15464 See related Ensembl:ENSG00000133710 MIM:605010; AllianceGenome:HGNC:15464 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NS; NETS; LEKTI; LETKI; VAKTI Summary This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] Expression Biased expression in esophagus (RPKM 472.7) and skin (RPKM 127.7) See more Orthologs mouse all