GPNMB, Official Symbol GPNMBprovided by HGNC Official Full Name glycoprotein nmbprovided by HGNC Primary source HGNC:HGNC:4462 See related Ensembl:ENSG00000136235 MIM:604368; AllianceGenome:HGNC:4462 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NMB; HGFIN; PLCA3 Summary The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 225.4), gall bladder (RPKM 143.5) and 17 other tissues See more Orthologs mouse all