CALB2, Official Symbol CALB2provided by HGNC Official Full Name calbindin 2provided by HGNC Primary source HGNC:HGNC:1435 See related Ensembl:ENSG00000172137 MIM:114051; AllianceGenome:HGNC:1435 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR; CAL2; CAB29 Summary This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Expression Biased expression in fat (RPKM 72.8), testis (RPKM 20.4) and 4 other tissues See more Orthologs mouse all