RLN1, Official Symbol RLN1provided by HGNC Official Full Name relaxin 1provided by HGNC Primary source HGNC:HGNC:10026 See related Ensembl:ENSG00000107018 MIM:179730; AllianceGenome:HGNC:10026 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2 Summary Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013] Expression Biased expression in prostate (RPKM 8.0) and testis (RPKM 0.2) See more Orthologs all