NRTN, Official Symbol NRTNprovided by HGNC Official Full Name neurturinprovided by HGNC Primary source HGNC:HGNC:8007 See related Ensembl:ENSG00000171119 MIM:602018; AllianceGenome:HGNC:8007 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTN Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016] Expression Broad expression in kidney (RPKM 1.6), heart (RPKM 1.4) and 18 other tissues See more Orthologs mouse all