CNOT2, Official Symbol CNOT2provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 2provided by HGNC Primary source HGNC:HGNC:7878 See related Ensembl:ENSG00000111596 MIM:604909; AllianceGenome:HGNC:7878 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOT2; CDC36; NOT2H; HSPC131; IDNADFS Summary This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in bone marrow (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues See more Orthologs mouse all