GBF1, Official Symbol GBF1provided by HGNC Official Full Name golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:4181 See related Ensembl:ENSG00000107862 MIM:603698; AllianceGenome:HGNC:4181 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMT2GG; CMTDI2; CMTDIA; ARF1GEF Summary This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in testis (RPKM 18.0), brain (RPKM 12.4) and 25 other tissues See more Orthologs mouse all