NOTUM, Official Symbol NOTUMprovided by HGNC Official Full Name notum, palmitoleoyl-protein carboxylesteraseprovided by HGNC Primary source HGNC:HGNC:27106 See related Ensembl:ENSG00000185269 MIM:609847; AllianceGenome:HGNC:27106 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hNOTUM Summary Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward placenta (RPKM 82.6) See more Orthologs mouse all