MC2R, Official Symbol MC2Rprovided by HGNC Official Full Name melanocortin 2 receptorprovided by HGNC Primary source HGNC:HGNC:6930 See related Ensembl:ENSG00000185231 MIM:607397; AllianceGenome:HGNC:6930 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACTHR Summary MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014] Expression Restricted expression toward adrenal (RPKM 16.0) See more Orthologs mouse all