AQP4, Official Symbol AQP4provided by HGNC Official Full Name aquaporin 4provided by HGNC Primary source HGNC:HGNC:637 See related Ensembl:ENSG00000171885 MIM:600308; AllianceGenome:HGNC:637 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIWC; MLC4; WCH4; hAQP4 Summary This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018] Expression Biased expression in brain (RPKM 248.2) and lung (RPKM 72.5) See more Orthologs mouse all