UBN1, Official Symbol UBN1provided by HGNC Official Full Name ubinuclein 1provided by HGNC Primary source HGNC:HGNC:12506 See related Ensembl:ENSG00000118900 MIM:609771; AllianceGenome:HGNC:12506 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VT; VT4 Summary Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016] Expression Broad expression in testis (RPKM 22.1), bone marrow (RPKM 13.0) and 25 other tissues See more Orthologs mouse all