WDR35, Official Symbol WDR35provided by HGNC Official Full Name WD repeat domain 35provided by HGNC Primary source HGNC:HGNC:29250 See related Ensembl:ENSG00000118965 MIM:613602; AllianceGenome:HGNC:29250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CED2; IFTA1; SRTD7; FAP118; IFT121; CFAP118 Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010] Expression Broad expression in testis (RPKM 8.4), thyroid (RPKM 5.2) and 24 other tissues See more Orthologs mouse all