MMP9, Official Symbol MMP9provided by HGNC Official Full Name matrix metallopeptidase 9provided by HGNC Primary source HGNC:HGNC:7176 See related Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GELB; CLG4B; MMP-9; MANDP2 Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 144.9), lymph node (RPKM 49.8) and 3 other tissues See more Orthologs mouse all