AATF, Official Symbol AATFprovided by HGNC Official Full Name apoptosis antagonizing transcription factorprovided by HGNC Primary source HGNC:HGNC:19235 See related Ensembl:ENSG00000275700 MIM:608463; AllianceGenome:HGNC:19235 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DED; BFR2; CHE1; CHE-1 Summary The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 16.6), appendix (RPKM 15.2) and 25 other tissues See more Orthologs mouse all