TNFRSF10C, Official Symbol TNFRSF10Cprovided by HGNC Official Full Name TNF receptor superfamily member 10cprovided by HGNC Primary source HGNC:HGNC:11906 See related Ensembl:ENSG00000173535 MIM:603613; AllianceGenome:HGNC:11906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 12.1), bone marrow (RPKM 9.2) and 17 other tissues See more Orthologs all