GDF10, Official Symbol GDF10provided by HGNC Official Full Name growth differentiation factor 10provided by HGNC Primary source HGNC:HGNC:4215 See related Ensembl:ENSG00000266524 MIM:601361; AllianceGenome:HGNC:4215 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIP; BMP3B; BMP-3b Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016] Expression Biased expression in lung (RPKM 8.6), fat (RPKM 5.4) and 12 other tissues See more Orthologs mouse all