LEF1, Official Symbol LEF1provided by HGNC Official Full Name lymphoid enhancer binding factor 1provided by HGNC Primary source HGNC:HGNC:6551 See related Ensembl:ENSG00000138795 MIM:153245; AllianceGenome:HGNC:6551 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEF-1; TCF10; TCF7L3; TCF1ALPHA Summary This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Expression Broad expression in lymph node (RPKM 17.6), appendix (RPKM 8.1) and 14 other tissues See more Orthologs mouse all