MRI1, Official Symbol MRI1provided by HGNC Official Full Name methylthioribose-1-phosphate isomerase 1provided by HGNC Primary source HGNC:HGNC:28469 See related Ensembl:ENSG00000037757 MIM:615105; AllianceGenome:HGNC:28469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M1Pi; MRDI; MTNA; Ypr118w Summary This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in placenta (RPKM 6.8), skin (RPKM 6.2) and 25 other tissues See more Orthologs mouse all