ORC5, Official Symbol ORC5provided by HGNC Official Full Name origin recognition complex subunit 5provided by HGNC Primary source HGNC:HGNC:8491 See related Ensembl:ENSG00000164815 MIM:602331; AllianceGenome:HGNC:8491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORC5L; ORC5P; ORC5T; PPP1R117 Summary The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 4.4) and 25 other tissues See more Orthologs mouse all