MTARC2, Official Symbol MTARC2provided by HGNC Official Full Name mitochondrial amidoxime reducing component 2provided by HGNC Primary source HGNC:HGNC:26064 See related Ensembl:ENSG00000117791 MIM:614127; AllianceGenome:HGNC:26064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARC2; MOSC2 Summary The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016] Expression Broad expression in kidney (RPKM 32.4), liver (RPKM 26.8) and 23 other tissues See more Orthologs mouse all