IL5RA, Official Symbol IL5RAprovided by HGNC Official Full Name interleukin 5 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:6017 See related Ensembl:ENSG00000091181 MIM:147851; AllianceGenome:HGNC:6017 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL5R; CD125; CDw125; HSIL5R3 Summary The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011] Expression Biased expression in lung (RPKM 1.2), prostate (RPKM 0.7) and 13 other tissues See more Orthologs mouse all