ELAC2, Official Symbol ELAC2provided by HGNC Official Full Name elaC ribonuclease Z 2provided by HGNC Primary source HGNC:HGNC:14198 See related Ensembl:ENSG00000006744 MIM:605367; AllianceGenome:HGNC:14198 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ELC2; HPC2; COXPD17 Summary The protein encoded by this gene has a C-terminal domain with tRNA 3&#8242; processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in colon (RPKM 15.0), testis (RPKM 14.9) and 25 other tissues See more Orthologs mouse all