MMP11, Official Symbol MMP11provided by HGNC Official Full Name matrix metallopeptidase 11provided by HGNC Primary source HGNC:HGNC:7157 See related Ensembl:ENSG00000099953 MIM:185261; AllianceGenome:HGNC:7157 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ST3; SL-3; STMY3 Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 149.1) and placenta (RPKM 32.3) See more Orthologs mouse all