ABHD2, Official Symbol ABHD2provided by HGNC Official Full Name abhydrolase domain containing 2, acylglycerol lipaseprovided by HGNC Primary source HGNC:HGNC:18717 See related Ensembl:ENSG00000140526 MIM:612196; AllianceGenome:HGNC:18717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HS1-2; LABH2; PHPS1-2 Summary This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in liver (RPKM 19.2), stomach (RPKM 14.4) and 25 other tissues See more Orthologs mouse all