GPR143, Official Symbol GPR143provided by HGNC Official Full Name G protein-coupled receptor 143provided by HGNC Primary source HGNC:HGNC:20145 See related Ensembl:ENSG00000101850 MIM:300808; AllianceGenome:HGNC:20145 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OA1; NYS6 Summary This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009] Expression Broad expression in skin (RPKM 3.2), placenta (RPKM 2.0) and 16 other tissues See more Orthologs mouse all