ROBO1, Official Symbol ROBO1provided by HGNC Official Full Name roundabout guidance receptor 1provided by HGNC Primary source HGNC:HGNC:10249 See related Ensembl:ENSG00000169855 MIM:602430; AllianceGenome:HGNC:10249 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NORS; NYS8; SAX3; CPHD8; DUTT1 Summary Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in brain (RPKM 11.9), skin (RPKM 9.4) and 23 other tissues See more Orthologs mouse all