FKBP1B, Official Symbol FKBP1Bprovided by HGNC Official Full Name FKBP prolyl isomerase 1Bprovided by HGNC Primary source HGNC:HGNC:3712 See related Ensembl:ENSG00000119782 MIM:600620; AllianceGenome:HGNC:3712 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 4.2), brain (RPKM 2.6) and 25 other tissues See more Orthologs mouse all