KL, Official Symbol KLprovided by HGNC Official Full Name klothoprovided by HGNC Primary source HGNC:HGNC:6344 See related Ensembl:ENSG00000133116 MIM:604824; AllianceGenome:HGNC:6344 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLA; HFTC3 Summary This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 80.6), placenta (RPKM 14.7) and 1 other tissue See more Orthologs mouse all