PDE4A, Official Symbol PDE4Aprovided by HGNC Official Full Name phosphodiesterase 4Aprovided by HGNC Primary source HGNC:HGNC:8780 See related Ensembl:ENSG00000065989 MIM:600126; AllianceGenome:HGNC:8780 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDE4; DPDE2; PDE46 Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Expression Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 5.3) and 24 other tissues See more Orthologs mouse all