POU2F3, Official Symbol POU2F3provided by HGNC Official Full Name POU class 2 homeobox 3provided by HGNC Primary source HGNC:HGNC:19864 See related Ensembl:ENSG00000137709 MIM:607394; AllianceGenome:HGNC:19864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLA1; OCT11; PLA-1; Epoc-1; OCT-11; OTF-11; Skn-1a Summary This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] Expression Biased expression in skin (RPKM 16.5) and lung (RPKM 0.4) See more Orthologs mouse all