PTPRR, Official Symbol PTPRRprovided by HGNC Official Full Name protein tyrosine phosphatase receptor type Rprovided by HGNC Primary source HGNC:HGNC:9680 See related Ensembl:ENSG00000153233 MIM:602853; AllianceGenome:HGNC:9680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7 Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011] Expression Biased expression in brain (RPKM 5.7), colon (RPKM 3.2) and 11 other tissues See more Orthologs mouse all