DNM1, Official Symbol DNM1provided by HGNC Official Full Name dynamin 1provided by HGNC Primary source HGNC:HGNC:2972 See related Ensembl:ENSG00000106976 MIM:602377; AllianceGenome:HGNC:2972 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DNM; DEE31; DEE31A; DEE31B; EIEE31 Summary This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 103.8) and gall bladder (RPKM 8.7) See more Orthologs mouse all