GCLM, Official Symbol GCLMprovided by HGNC Official Full Name glutamate-cysteine ligase modifier subunitprovided by HGNC Primary source HGNC:HGNC:4312 See related Ensembl:ENSG00000023909 MIM:601176; AllianceGenome:HGNC:4312 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLCLR Summary Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Expression Ubiquitous expression in liver (RPKM 13.0), thyroid (RPKM 9.9) and 24 other tissues See more Orthologs mouse all