HES5, Official Symbol HES5provided by HGNC Official Full Name hes family bHLH transcription factor 5provided by HGNC Primary source HGNC:HGNC:19764 See related Ensembl:ENSG00000197921 MIM:607348; AllianceGenome:HGNC:19764 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bHLHb38 Summary This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all