CLCA2, Official Symbol CLCA2provided by HGNC Official Full Name chloride channel accessory 2provided by HGNC Primary source HGNC:HGNC:2016 See related Ensembl:ENSG00000137975 MIM:604003; AllianceGenome:HGNC:2016 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CACC; CACC3; CLCRG2; CaCC-3 Summary This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016] Expression Biased expression in esophagus (RPKM 67.2), skin (RPKM 43.6) and 1 other tissue See more Orthologs mouse all