AIF1, Official Symbol AIF1provided by HGNC Official Full Name allograft inflammatory factor 1provided by HGNC Primary source HGNC:HGNC:352 See related Ensembl:ENSG00000204472 MIM:601833; AllianceGenome:HGNC:352 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IBA1; IRT1; AIF-1; IRT-1 Summary This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016] Expression Broad expression in spleen (RPKM 100.3), appendix (RPKM 74.7) and 17 other tissues See more Orthologs mouse all