HECTD3, Official Symbol HECTD3provided by HGNC Official Full Name HECT domain E3 ubiquitin protein ligase 3provided by HGNC Primary source HGNC:HGNC:26117 See related Ensembl:ENSG00000126107 MIM:618638; AllianceGenome:HGNC:26117 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in duodenum (RPKM 25.9), small intestine (RPKM 22.6) and 25 other tissues See more Orthologs mouse all