PZP, Official Symbol PZPprovided by HGNC Official Full Name PZP alpha-2-macroglobulin likeprovided by HGNC Primary source HGNC:HGNC:9750 See related Ensembl:ENSG00000126838 MIM:176420; AllianceGenome:HGNC:9750 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPAMD6 Summary The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016] Expression Biased expression in liver (RPKM 5.3), endometrium (RPKM 1.0) and 2 other tissues See more Orthologs all