MYCN, Official Symbol MYCNprovided by HGNC Official Full Name MYCN proto-oncogene, bHLH transcription factorprovided by HGNC Primary source HGNC:HGNC:7559 See related Ensembl:ENSG00000134323 MIM:164840; AllianceGenome:HGNC:7559 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NMYC; ODED; MODED; N-myc; bHLHe37; MYCNsORF; MYCNsPEP Summary This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] Expression Broad expression in placenta (RPKM 4.0), ovary (RPKM 2.1) and 14 other tissues See more Orthologs mouse all