PER2, Official Symbol PER2provided by HGNC Official Full Name period circadian regulator 2provided by HGNC Primary source HGNC:HGNC:8846 See related Ensembl:ENSG00000132326 MIM:603426; AllianceGenome:HGNC:8846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FASPS; FASPS1 Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in testis (RPKM 8.7), gall bladder (RPKM 7.6) and 25 other tissues See more Orthologs mouse all