SRSF4, Official Symbol SRSF4provided by HGNC Official Full Name serine and arginine rich splicing factor 4provided by HGNC Primary source HGNC:HGNC:10786 See related Ensembl:ENSG00000116350 MIM:601940; AllianceGenome:HGNC:10786 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRS4; SRP75 Summary Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 33.0), bone marrow (RPKM 32.4) and 25 other tissues See more Orthologs mouse all