MED27, Official Symbol MED27provided by HGNC Official Full Name mediator complex subunit 27provided by HGNC Primary source HGNC:HGNC:2377 See related Ensembl:ENSG00000160563 MIM:605044; AllianceGenome:HGNC:2377 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED3; CRSP8; CRAP34; CRSP34; TRAP37; NEDSCAC Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.0) and 25 other tissues See more Orthologs mouse all