REPS2, Official Symbol REPS2provided by HGNC Official Full Name RALBP1 associated Eps domain containing 2provided by HGNC Primary source HGNC:HGNC:9963 See related Ensembl:ENSG00000169891 MIM:300317; AllianceGenome:HGNC:9963 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POB1 Summary The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 10.4), adrenal (RPKM 6.0) and 23 other tissues See more Orthologs mouse all