MXD1, Official Symbol MXD1provided by HGNC Official Full Name MAX dimerization protein 1provided by HGNC Primary source HGNC:HGNC:6761 See related Ensembl:ENSG00000059728 MIM:600021; AllianceGenome:HGNC:6761 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAD; MAD1; BHLHC58 Summary This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in bone marrow (RPKM 58.4), esophagus (RPKM 54.2) and 16 other tissues See more Orthologs mouse all