PLPP2, Official Symbol PLPP2provided by HGNC Official Full Name phospholipid phosphatase 2provided by HGNC Primary source HGNC:HGNC:9230 See related Ensembl:ENSG00000141934 MIM:607126; AllianceGenome:HGNC:9230 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPP2; PAP-2c; PAP2-g; PPAP2C Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues See more Orthologs mouse all