CDSN, Official Symbol CDSNprovided by HGNC Official Full Name corneodesmosinprovided by HGNC Primary source HGNC:HGNC:1802 See related Ensembl:ENSG00000204539 MIM:602593; AllianceGenome:HGNC:1802 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSS; HTSS; PSS1; HTSS1; HYPT2 Summary This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014] Expression Restricted expression toward skin (RPKM 78.3) See more Orthologs mouse all