HSPB8, Official Symbol HSPB8provided by HGNC Official Full Name heat shock protein family B (small) member 8provided by HGNC Primary source HGNC:HGNC:30171 See related Ensembl:ENSG00000152137 MIM:608014; AllianceGenome:HGNC:30171 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; HSPB8-N1; HSPB8-N2 Summary The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 181.8), esophagus (RPKM 96.6) and 15 other tissues See more Orthologs mouse all