GRB14, Official Symbol GRB14provided by HGNC Official Full Name growth factor receptor bound protein 14provided by HGNC Primary source HGNC:HGNC:4565 See related Ensembl:ENSG00000115290 MIM:601524; AllianceGenome:HGNC:4565 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Biased expression in kidney (RPKM 7.9), liver (RPKM 7.8) and 12 other tissues See more Orthologs mouse all