ABCB4, Official Symbol ABCB4provided by HGNC Official Full Name ATP binding cassette subfamily B member 4provided by HGNC Primary source HGNC:HGNC:45 See related Ensembl:ENSG00000005471 MIM:171060; AllianceGenome:HGNC:45 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3 Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 23.8), adrenal (RPKM 3.1) and 3 other tissues See more Orthologs all