UROS, Official Symbol UROSprovided by HGNC Official Full Name uroporphyrinogen III synthaseprovided by HGNC Primary source HGNC:HGNC:12592 See related Ensembl:ENSG00000188690 MIM:606938; AllianceGenome:HGNC:12592 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UROIIIS Summary The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 4.5), brain (RPKM 4.4) and 25 other tissues See more Orthologs mouse all