GPR153, Official Symbol GPR153provided by HGNC Official Full Name G protein-coupled receptor 153provided by HGNC Primary source HGNC:HGNC:23618 See related Ensembl:ENSG00000158292 MIM:614269; AllianceGenome:HGNC:23618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR1 Summary This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017] Expression Broad expression in colon (RPKM 6.6), fat (RPKM 4.7) and 21 other tissues See more Orthologs mouse all