KPNA1, Official Symbol KPNA1provided by HGNC Official Full Name karyopherin subunit alpha 1provided by HGNC Primary source HGNC:HGNC:6394 See related Ensembl:ENSG00000114030 MIM:600686; AllianceGenome:HGNC:6394 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCH2; SRP1; IPOA5; NPI-1 Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in brain (RPKM 10.0), testis (RPKM 7.9) and 25 other tissues See more Orthologs mouse all