SV2B, Official Symbol SV2Bprovided by HGNC Official Full Name synaptic vesicle glycoprotein 2Bprovided by HGNC Primary source HGNC:HGNC:16874 See related Ensembl:ENSG00000185518 MIM:185861; AllianceGenome:HGNC:16874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLC22B2; HsT19680 Summary This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016] Expression Biased expression in brain (RPKM 7.7) and fat (RPKM 1.1) See more Orthologs mouse all