SPTBN4, Official Symbol SPTBN4provided by HGNC Official Full Name spectrin beta, non-erythrocytic 4provided by HGNC Primary source HGNC:HGNC:14896 See related Ensembl:ENSG00000160460 MIM:606214; AllianceGenome:HGNC:14896 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as QV; CMND; SPNB4; NEDHND; SPTBN3 Summary Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.1), testis (RPKM 0.9) and 9 other tissues See more Orthologs mouse all