PDK4, Official Symbol PDK4provided by HGNC Official Full Name pyruvate dehydrogenase kinase 4provided by HGNC Primary source HGNC:HGNC:8812 See related Ensembl:ENSG00000004799 MIM:602527; AllianceGenome:HGNC:8812 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 319.9), adrenal (RPKM 136.4) and 18 other tissues See more Orthologs mouse all