C1S, Official Symbol C1Sprovided by HGNC Official Full Name complement C1sprovided by HGNC Primary source HGNC:HGNC:1247 See related Ensembl:ENSG00000182326 MIM:120580; AllianceGenome:HGNC:1247 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDSPD2 Summary This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009] Expression Broad expression in liver (RPKM 683.7), gall bladder (RPKM 363.8) and 18 other tissues See more Orthologs mouse all