CDCA4, Official Symbol CDCA4provided by HGNC Official Full Name cell division cycle associated 4provided by HGNC Primary source HGNC:HGNC:14625 See related Ensembl:ENSG00000170779 MIM:612270; AllianceGenome:HGNC:14625 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEPP; SEI-3/HEPP Summary This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014] Expression Broad expression in bone marrow (RPKM 19.7), placenta (RPKM 6.5) and 19 other tissues See more Orthologs mouse all