ZNF420, Official Symbol ZNF420provided by HGNC Official Full Name zinc finger protein 420provided by HGNC Primary source HGNC:HGNC:20649 See related Ensembl:ENSG00000197050 MIM:617216; AllianceGenome:HGNC:20649 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APAK Summary The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in testis (RPKM 3.6), ovary (RPKM 3.4) and 25 other tissues See more Orthologs all