PPAT, Official Symbol PPATprovided by HGNC Official Full Name phosphoribosyl pyrophosphate amidotransferaseprovided by HGNC Primary source HGNC:HGNC:9238 See related Ensembl:ENSG00000128059 MIM:172450; AllianceGenome:HGNC:9238 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPAT; PRAT; ATASE Summary The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in testis (RPKM 6.9), lymph node (RPKM 5.0) and 25 other tissues See more Orthologs mouse all