MDC1, Official Symbol MDC1provided by HGNC Official Full Name mediator of DNA damage checkpoint 1provided by HGNC Primary source HGNC:HGNC:21163 See related Ensembl:ENSG00000137337 MIM:607593; AllianceGenome:HGNC:21163 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NFBD1 Summary The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 20.6), thyroid (RPKM 7.4) and 25 other tissues See more Orthologs mouse all