MAP4K2, Official Symbol MAP4K2provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 2provided by HGNC Primary source HGNC:HGNC:6864 See related Ensembl:ENSG00000168067 MIM:603166; AllianceGenome:HGNC:6864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCK; BL44; RAB8IP Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Broad expression in spleen (RPKM 10.3), lymph node (RPKM 8.4) and 24 other tissues See more Orthologs mouse all