TRIP12, Official Symbol TRIP12provided by HGNC Official Full Name thyroid hormone receptor interactor 12provided by HGNC Primary source HGNC:HGNC:12306 See related Ensembl:ENSG00000153827 MIM:604506; AllianceGenome:HGNC:12306 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ULF; MRD49; TRIPC; TRIP-12 Summary The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017] Expression Broad expression in testis (RPKM 48.5), thyroid (RPKM 17.6) and 24 other tissues See more Orthologs mouse all