SPIRE2, Official Symbol SPIRE2provided by HGNC Official Full Name spire type actin nucleation factor 2provided by HGNC Primary source HGNC:HGNC:30623 See related Ensembl:ENSG00000204991 MIM:609217; AllianceGenome:HGNC:30623 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Spir-2 Summary Predicted to enable actin binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Predicted to colocalize with cleavage furrow. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in stomach (RPKM 4.5), colon (RPKM 4.1) and 20 other tissues See more Orthologs mouse all