PTPRN, Official Symbol PTPRNprovided by HGNC Official Full Name protein tyrosine phosphatase receptor type Nprovided by HGNC Primary source HGNC:HGNC:9676 See related Ensembl:ENSG00000054356 MIM:601773; AllianceGenome:HGNC:9676 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] Expression Biased expression in brain (RPKM 53.0), adrenal (RPKM 12.2) and 2 other tissues See more Orthologs mouse all