UIMC1, Official Symbol UIMC1provided by HGNC Official Full Name ubiquitin interaction motif containing 1provided by HGNC Primary source HGNC:HGNC:30298 See related Ensembl:ENSG00000087206 MIM:609433; AllianceGenome:HGNC:30298 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAP80; X2HRIP110 Summary This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Broad expression in testis (RPKM 26.7), bone marrow (RPKM 12.5) and 24 other tissues See more Orthologs mouse all