GAS2, Official Symbol GAS2provided by HGNC Official Full Name growth arrest specific 2provided by HGNC Primary source HGNC:HGNC:4167 See related Ensembl:ENSG00000148935 MIM:602835; AllianceGenome:HGNC:4167 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAS-2 Summary The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017] Expression Broad expression in liver (RPKM 2.8), kidney (RPKM 0.9) and 21 other tissues See more Orthologs mouse all