NUF2, Official Symbol NUF2provided by HGNC Official Full Name NUF2 component of NDC80 kinetochore complexprovided by HGNC Primary source HGNC:HGNC:14621 See related Ensembl:ENSG00000143228 MIM:611772; AllianceGenome:HGNC:14621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDCA1; CT106; NUF2R Summary This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 23.0), bone marrow (RPKM 9.4) and 11 other tissues See more Orthologs mouse all