HDC, Official Symbol HDCprovided by HGNC Official Full Name histidine decarboxylaseprovided by HGNC Primary source HGNC:HGNC:4855 See related Ensembl:ENSG00000140287 MIM:142704; AllianceGenome:HGNC:4855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010] Expression Broad expression in gall bladder (RPKM 9.0), stomach (RPKM 6.4) and 14 other tissues See more Orthologs mouse all