ACACB, Official Symbol ACACBprovided by HGNC Official Full Name acetyl-CoA carboxylase betaprovided by HGNC Primary source HGNC:HGNC:85 See related Ensembl:ENSG00000076555 MIM:601557; AllianceGenome:HGNC:85 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta Summary Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022] Expression Biased expression in fat (RPKM 94.8), liver (RPKM 8.9) and 6 other tissues See more Orthologs mouse all