SNCA, Official Symbol SNCAprovided by HGNC Official Full Name synuclein alphaprovided by HGNC Primary source HGNC:HGNC:11138 See related Ensembl:ENSG00000145335 MIM:163890; AllianceGenome:HGNC:11138 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PD1; NACP; PARK1; PARK4 Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] Expression Biased expression in brain (RPKM 59.2), bone marrow (RPKM 24.6) and 2 other tissues See more Orthologs mouse all