KCNQ2, Official Symbol KCNQ2provided by HGNC Official Full Name potassium voltage-gated channel subfamily Q member 2provided by HGNC Primary source HGNC:HGNC:6296 See related Ensembl:ENSG00000075043 MIM:602235; AllianceGenome:HGNC:6296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EBN; BFNC; DEE7; EBN1; ENB1; HNSPC; KV7.2; KCNA11 Summary The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 15.5), adrenal (RPKM 2.3) and 1 other tissue See more Orthologs mouse all