PRSS8, Official Symbol PRSS8provided by HGNC Official Full Name serine protease 8provided by HGNC Primary source HGNC:HGNC:9491 See related Ensembl:ENSG00000052344 MIM:600823; AllianceGenome:HGNC:9491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAP1; PROSTASIN Summary This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016] Expression Broad expression in small intestine (RPKM 73.7), colon (RPKM 73.6) and 14 other tissues See more Orthologs mouse all