EFNA2, Official Symbol EFNA2provided by HGNC Official Full Name ephrin A2provided by HGNC Primary source HGNC:HGNC:3222 See related Ensembl:ENSG00000099617 MIM:602756; AllianceGenome:HGNC:3222 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ELF-1; EPLG6; LERK6; HEK7-L; LERK-6 Summary This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008] Expression Biased expression in small intestine (RPKM 3.0), colon (RPKM 2.7) and 5 other tissues See more Orthologs mouse all