WFDC12, Official Symbol WFDC12provided by HGNC Official Full Name WAP four-disulfide core domain 12provided by HGNC Primary source HGNC:HGNC:16115 See related Ensembl:ENSG00000168703 MIM:609872; AllianceGenome:HGNC:16115 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP2; SWAM2; C20orf122; dJ211D12.4 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 13.5) and esophagus (RPKM 0.8) See more Orthologs all