CHAF1B, Official Symbol CHAF1Bprovided by HGNC Official Full Name chromatin assembly factor 1 subunit Bprovided by HGNC Primary source HGNC:HGNC:1911 See related Ensembl:ENSG00000159259 MIM:601245; AllianceGenome:HGNC:1911 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAF1; MPP7; CAF-1; CAF1A; CAF1P60; CAF-IP60; MPHOSPH7 Summary Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 2.7), testis (RPKM 2.6) and 25 other tissues See more Orthologs mouse all