LOX, Official Symbol LOXprovided by HGNC Official Full Name lysyl oxidaseprovided by HGNC Primary source HGNC:HGNC:6664 See related Ensembl:ENSG00000113083 MIM:153455; AllianceGenome:HGNC:6664 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAT10 Summary This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] Expression Broad expression in fat (RPKM 18.5), gall bladder (RPKM 11.6) and 21 other tissues See more Orthologs mouse all