JAM2, Official Symbol JAM2provided by HGNC Official Full Name junctional adhesion molecule 2provided by HGNC Primary source HGNC:HGNC:14686 See related Ensembl:ENSG00000154721 MIM:606870; AllianceGenome:HGNC:14686 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JAMB; CD322; IBGC8; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43 Summary This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012] Expression Broad expression in placenta (RPKM 25.9), brain (RPKM 13.2) and 20 other tissues See more Orthologs mouse all