TAB2, Official Symbol TAB2provided by HGNC Official Full Name TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC Primary source HGNC:HGNC:17075 See related Ensembl:ENSG00000055208 MIM:605101; AllianceGenome:HGNC:17075 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHTD2; TAB-2; MAP3K7IP2 Summary The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues See more Orthologs mouse all