MAP3K10, Official Symbol MAP3K10provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 10provided by HGNC Primary source HGNC:HGNC:6849 See related Ensembl:ENSG00000130758 MIM:600137; AllianceGenome:HGNC:6849 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST; MLK2; MEKK10 Summary The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues See more Orthologs mouse all