BLK, Official Symbol BLKprovided by HGNC Official Full Name BLK proto-oncogene, Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:1057 See related Ensembl:ENSG00000136573 MIM:191305; AllianceGenome:HGNC:1057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MODY11 Summary This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010] Expression Biased expression in lymph node (RPKM 18.9), spleen (RPKM 13.7) and 4 other tissues See more Orthologs mouse all