ODC1, Official Symbol ODC1provided by HGNC Official Full Name ornithine decarboxylase 1provided by HGNC Primary source HGNC:HGNC:8109 See related Ensembl:ENSG00000115758 MIM:165640; AllianceGenome:HGNC:8109 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ODC; BABS; NEDBA; NEDBIA Summary This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013] Expression Broad expression in testis (RPKM 67.6), bone marrow (RPKM 54.4) and 24 other tissues See more Orthologs mouse all