PDLIM3, Official Symbol PDLIM3provided by HGNC Official Full Name PDZ and LIM domain 3provided by HGNC Primary source HGNC:HGNC:20767 See related Ensembl:ENSG00000154553 MIM:605889; AllianceGenome:HGNC:20767 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALP Summary The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012] Expression Broad expression in esophagus (RPKM 61.1), heart (RPKM 58.0) and 19 other tissues See more Orthologs mouse all