GNMT, Official Symbol GNMTprovided by HGNC Official Full Name glycine N-methyltransferaseprovided by HGNC Primary source HGNC:HGNC:4415 See related Ensembl:ENSG00000124713 MIM:606628; AllianceGenome:HGNC:4415 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEL-S-182mP Summary The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 73.9), pancreas (RPKM 27.4) and 1 other tissue See more Orthologs mouse all