TNFRSF21, Official Symbol TNFRSF21provided by HGNC Official Full Name TNF receptor superfamily member 21provided by HGNC Primary source HGNC:HGNC:13469 See related Ensembl:ENSG00000146072 MIM:605732; AllianceGenome:HGNC:13469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR6; CD358; BM-018 Summary This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013] Expression Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues See more Orthologs mouse all