GPS2, Official Symbol GPS2provided by HGNC Official Full Name G protein pathway suppressor 2provided by HGNC Primary source HGNC:HGNC:4550 See related Ensembl:ENSG00000132522 MIM:601935; AllianceGenome:HGNC:4550 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMF-1 Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 54.8), spleen (RPKM 24.3) and 25 other tissues See more Orthologs mouse all