CAPN2, Official Symbol CAPN2provided by HGNC Official Full Name calpain 2provided by HGNC Primary source HGNC:HGNC:1479 See related Ensembl:ENSG00000162909 MIM:114230; AllianceGenome:HGNC:1479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CANP2; mCANP; CANPL2; CANPml Summary The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in lung (RPKM 90.0), gall bladder (RPKM 66.0) and 25 other tissues See more Orthologs mouse all