PTPN18, Official Symbol PTPN18provided by HGNC Official Full Name protein tyrosine phosphatase non-receptor type 18provided by HGNC Primary source HGNC:HGNC:9649 See related Ensembl:ENSG00000072135 MIM:606587; AllianceGenome:HGNC:9649 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDP1; PTP-HSCF Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in lymph node (RPKM 34.1), spleen (RPKM 27.5) and 25 other tissues See more Orthologs mouse all