PDE5A, Official Symbol PDE5Aprovided by HGNC Official Full Name phosphodiesterase 5Aprovided by HGNC Primary source HGNC:HGNC:8784 See related Ensembl:ENSG00000138735 MIM:603310; AllianceGenome:HGNC:8784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CN5A; PDE5; CGB-PDE Summary This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 31.5), esophagus (RPKM 20.9) and 20 other tissues See more Orthologs mouse all