PPP1R3C, Official Symbol PPP1R3Cprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Cprovided by HGNC Primary source HGNC:HGNC:9293 See related Ensembl:ENSG00000119938 MIM:602999; AllianceGenome:HGNC:9293 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTG; PPP1R5 Summary This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016] Expression Broad expression in heart (RPKM 69.5), esophagus (RPKM 32.0) and 14 other tissues See more Orthologs mouse all