UNC13B, Official Symbol UNC13Bprovided by HGNC Official Full Name unc-13 homolog Bprovided by HGNC Primary source HGNC:HGNC:12566 See related Ensembl:ENSG00000198722 MIM:605836; AllianceGenome:HGNC:12566 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC13; MUNC13; Unc13h2; munc13-2 Summary This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 12.8), kidney (RPKM 6.6) and 23 other tissues See more Orthologs mouse all