DNMT3A, Official Symbol DNMT3Aprovided by HGNC Official Full Name DNA methyltransferase 3 alphaprovided by HGNC Primary source HGNC:HGNC:2978 See related Ensembl:ENSG00000119772 MIM:602769; AllianceGenome:HGNC:2978 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TBRS; HESJAS; DNMT3A2; M.HsaIIIA Summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in placenta (RPKM 5.8), ovary (RPKM 3.9) and 25 other tissues See more Orthologs mouse all