EVPL, Official Symbol EVPLprovided by HGNC Official Full Name envoplakinprovided by HGNC Primary source HGNC:HGNC:3503 See related Ensembl:ENSG00000167880 MIM:601590; AllianceGenome:HGNC:3503 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EVPK Summary This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016] Expression Biased expression in skin (RPKM 47.9), esophagus (RPKM 41.4) and 9 other tissues See more Orthologs mouse all