NEDD4L, Official Symbol NEDD4Lprovided by HGNC Official Full Name NEDD4 like E3 ubiquitin protein ligaseprovided by HGNC Primary source HGNC:HGNC:7728 See related Ensembl:ENSG00000049759 MIM:606384; AllianceGenome:HGNC:7728 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2 Summary This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in prostate (RPKM 13.1), kidney (RPKM 13.0) and 25 other tissues See more Orthologs mouse all