SLC1A1, Official Symbol SLC1A1provided by HGNC Official Full Name solute carrier family 1 member 1provided by HGNC Primary source HGNC:HGNC:10939 See related Ensembl:ENSG00000106688 MIM:133550; AllianceGenome:HGNC:10939 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCBXA; EAAC1; EAAT3; SCZD18; hEAAC1 Summary This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010] Expression Biased expression in small intestine (RPKM 11.7), kidney (RPKM 8.4) and 12 other tissues See more Orthologs mouse all