TRADD, Official Symbol TRADDprovided by HGNC Official Full Name TNFRSF1A associated via death domainprovided by HGNC Primary source HGNC:HGNC:12030 See related Ensembl:ENSG00000102871 MIM:603500; AllianceGenome:HGNC:12030 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hs.89862 Summary The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues See more Orthologs mouse all