NEFM, Official Symbol NEFMprovided by HGNC Official Full Name neurofilament medium chainprovided by HGNC Primary source HGNC:HGNC:7734 See related Ensembl:ENSG00000104722 MIM:162250; AllianceGenome:HGNC:7734 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NFM; NEF3; NF-M Summary Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Expression Biased expression in brain (RPKM 56.0), adrenal (RPKM 9.7) and 1 other tissue See more Orthologs mouse all