ITGAD, Official Symbol ITGADprovided by HGNC Official Full Name integrin subunit alpha Dprovided by HGNC Primary source HGNC:HGNC:6146 See related Ensembl:ENSG00000156886 MIM:602453; AllianceGenome:HGNC:6146 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADB2; CD11D Summary This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in spleen (RPKM 11.2), lymph node (RPKM 2.1) and 2 other tissues See more Orthologs mouse all