ZCRB1, Official Symbol ZCRB1provided by HGNC Official Full Name zinc finger CCHC-type and RNA binding motif containing 1provided by HGNC Primary source HGNC:HGNC:29620 See related Ensembl:ENSG00000139168 MIM:610750; AllianceGenome:HGNC:29620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19 Summary Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 32.6), brain (RPKM 19.2) and 25 other tissues See more Orthologs mouse all