SESN3, Official Symbol SESN3provided by HGNC Official Full Name sestrin 3provided by HGNC Primary source HGNC:HGNC:23060 See related Ensembl:ENSG00000149212 MIM:607768; AllianceGenome:HGNC:23060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEST3 Summary This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues See more Orthologs mouse all