CD14, Official Symbol CD14provided by HGNC Official Full Name CD14 moleculeprovided by HGNC Primary source HGNC:HGNC:1628 See related Ensembl:ENSG00000170458 MIM:158120; AllianceGenome:HGNC:1628 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment. Expression Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues See more Orthologs mouse all