GPSM2, Official Symbol GPSM2provided by HGNC Official Full Name G protein signaling modulator 2provided by HGNC Primary source HGNC:HGNC:29501 See related Ensembl:ENSG00000121957 MIM:609245; AllianceGenome:HGNC:29501 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LGN; CMCS; PINS; DFNB82 Summary The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in skin (RPKM 9.6), esophagus (RPKM 8.8) and 24 other tissues See more Orthologs mouse all