TBCE, Official Symbol TBCEprovided by HGNC Official Full Name tubulin folding cofactor Eprovided by HGNC Primary source HGNC:HGNC:11582 See related Ensembl:ENSG00000284770 MIM:604934; AllianceGenome:HGNC:11582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRD; KCS; KCS1; pac2; PEAMO Summary Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 12.9), testis (RPKM 6.5) and 25 other tissues See more Orthologs mouse all