FAN1, Official Symbol FAN1provided by HGNC Official Full Name FANCD2 and FANCI associated nuclease 1provided by HGNC Primary source HGNC:HGNC:29170 See related Ensembl:ENSG00000198690 MIM:613534; AllianceGenome:HGNC:29170 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KMIN; hFAN1; MTMR15; KIAA1018 Summary This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in skin (RPKM 6.7), brain (RPKM 6.7) and 25 other tissues See more Orthologs mouse all