ANGPTL4, Official Symbol ANGPTL4provided by HGNC Official Full Name angiopoietin like 4provided by HGNC Primary source HGNC:HGNC:16039 See related Ensembl:ENSG00000167772 MIM:605910; AllianceGenome:HGNC:16039 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158 Summary This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013] Expression Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues See more Orthologs mouse all