ENDOU, Official Symbol ENDOUprovided by HGNC Official Full Name endonuclease, poly(U) specificprovided by HGNC Primary source HGNC:HGNC:14369 See related Ensembl:ENSG00000111405 MIM:606720; AllianceGenome:HGNC:14369 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P11; PP11; PRSS26 Summary This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020] Expression Biased expression in esophagus (RPKM 34.0), skin (RPKM 9.4) and 1 other tissue See more Orthologs mouse all