NECTIN2, Official Symbol NECTIN2provided by HGNC Official Full Name nectin cell adhesion molecule 2provided by HGNC Primary source HGNC:HGNC:9707 See related Ensembl:ENSG00000130202 MIM:600798; AllianceGenome:HGNC:9707 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HVEB; PRR2; CD112; PVRL2; PVRR2 Summary This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 24.8), testis (RPKM 23.6) and 25 other tissues See more Orthologs mouse all