SOS1, Official Symbol SOS1provided by HGNC Official Full Name SOS Ras/Rac guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:11187 See related Ensembl:ENSG00000115904 MIM:182530; AllianceGenome:HGNC:11187 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GF1; HGF; NS4; GGF1; GINGF; SOS-1 Summary This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 10.4), ovary (RPKM 10.2) and 25 other tissues See more Orthologs mouse all