MCOLN2, Official Symbol MCOLN2provided by HGNC Official Full Name mucolipin TRP cation channel 2provided by HGNC Primary source HGNC:HGNC:13357 See related Ensembl:ENSG00000153898 MIM:607399; AllianceGenome:HGNC:13357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRPML2; TRP-ML2 Summary Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009] Expression Broad expression in lymph node (RPKM 3.6), spleen (RPKM 2.0) and 14 other tissues See more Orthologs mouse all