MYO6, Official Symbol MYO6provided by HGNC Official Full Name myosin VIprovided by HGNC Primary source HGNC:HGNC:7605 See related Ensembl:ENSG00000196586 MIM:600970; AllianceGenome:HGNC:7605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNA22; DFNB37 Summary This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] Expression Broad expression in kidney (RPKM 22.2), duodenum (RPKM 13.0) and 23 other tissues See more Orthologs mouse all