CD2BP2, Official Symbol CD2BP2provided by HGNC Official Full Name CD2 cytoplasmic tail binding protein 2provided by HGNC Primary source HGNC:HGNC:1656 See related Ensembl:ENSG00000169217 MIM:604470; AllianceGenome:HGNC:1656 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIN1; Snu40; FWP010; U5-52K; PPP1R59 Summary This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in brain (RPKM 16.4), lymph node (RPKM 14.8) and 25 other tissues See more Orthologs mouse all