PPFIA1, Official Symbol PPFIA1provided by HGNC Official Full Name PTPRF interacting protein alpha 1provided by HGNC Primary source HGNC:HGNC:9245 See related Ensembl:ENSG00000131626 MIM:611054; AllianceGenome:HGNC:9245 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIP1; LIP.1; LIPRIN Summary The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.0), thyroid (RPKM 12.7) and 25 other tissues See more Orthologs mouse all