TNFRSF10A, Official Symbol TNFRSF10Aprovided by HGNC Official Full Name TNF receptor superfamily member 10aprovided by HGNC Primary source HGNC:HGNC:11904 See related Ensembl:ENSG00000104689 MIM:603611; AllianceGenome:HGNC:11904 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR4; APO2; CD261; TRAILR1; TRAILR-1 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 4.9), appendix (RPKM 4.2) and 24 other tissues See more Orthologs all