PSMB4, Official Symbol PSMB4provided by HGNC Official Full Name proteasome 20S subunit beta 4provided by HGNC Primary source HGNC:HGNC:9541 See related Ensembl:ENSG00000159377 MIM:602177; AllianceGenome:HGNC:9541 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HN3; HsN3; PRAAS3; PROS26; PROS-26 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 102.8), lymph node (RPKM 94.8) and 25 other tissues See more Orthologs mouse all