CD74, Official Symbol CD74provided by HGNC Official Full Name CD74 moleculeprovided by HGNC Primary source HGNC:HGNC:1697 See related Ensembl:ENSG00000019582 MIM:142790; AllianceGenome:HGNC:1697 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as II; p33; CLIP; DHLAG; HLADG; Ia-GAMMA Summary The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] Expression Broad expression in spleen (RPKM 1835.3), lymph node (RPKM 1421.7) and 24 other tissues See more Orthologs mouse all