SOX8, Official Symbol SOX8provided by HGNC Official Full Name SRY-box transcription factor 8provided by HGNC Primary source HGNC:HGNC:11203 See related Ensembl:ENSG00000005513 MIM:605923; AllianceGenome:HGNC:11203 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017] Expression Biased expression in brain (RPKM 44.7) and salivary gland (RPKM 3.1) See more Orthologs mouse all