TLE1, Official Symbol TLE1provided by HGNC Official Full Name TLE family member 1, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11837 See related Ensembl:ENSG00000196781 MIM:600189; AllianceGenome:HGNC:11837 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; ESG1; GRG1; TLE-1 Summary Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues See more Orthologs all