GCM2, Official Symbol GCM2provided by HGNC Official Full Name glial cells missing transcription factor 2provided by HGNC Primary source HGNC:HGNC:4198 See related Ensembl:ENSG00000124827 MIM:603716; AllianceGenome:HGNC:4198 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIH2; GCMB; HRPT4; hGCMb Summary This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all