COPS8, Official Symbol COPS8provided by HGNC Official Full Name COP9 signalosome subunit 8provided by HGNC Primary source HGNC:HGNC:24335 See related Ensembl:ENSG00000198612 MIM:616011; AllianceGenome:HGNC:24335 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COP9; CSN8; SGN8 Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues See more Orthologs mouse all