GRK4, Official Symbol GRK4provided by HGNC Official Full Name G protein-coupled receptor kinase 4provided by HGNC Primary source HGNC:HGNC:4543 See related Ensembl:ENSG00000125388 MIM:137026; AllianceGenome:HGNC:4543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IT11; GPRK4; GRK4a; GPRK2L Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7) See more Orthologs mouse all