NOX4, Official Symbol NOX4provided by HGNC Official Full Name NADPH oxidase 4provided by HGNC Primary source HGNC:HGNC:7891 See related Ensembl:ENSG00000086991 MIM:605261; AllianceGenome:HGNC:7891 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KOX; KOX-1; RENOX Summary This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] Expression Biased expression in kidney (RPKM 23.6) and endometrium (RPKM 1.5) See more Orthologs mouse all