CPE, Official Symbol CPEprovided by HGNC Official Full Name carboxypeptidase Eprovided by HGNC Primary source HGNC:HGNC:2303 See related Ensembl:ENSG00000109472 MIM:114855; AllianceGenome:HGNC:2303 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPH; BDVS; IDDHH Summary This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015] Expression Biased expression in brain (RPKM 491.8), prostate (RPKM 192.3) and 11 other tissues See more Orthologs mouse all