FBXW11, Official Symbol FBXW11provided by HGNC Official Full Name F-box and WD repeat domain containing 11provided by HGNC Primary source HGNC:HGNC:13607 See related Ensembl:ENSG00000072803 MIM:605651; AllianceGenome:HGNC:13607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues See more Orthologs mouse all