XPA, Official Symbol XPAprovided by HGNC Official Full Name XPA, DNA damage recognition and repair factorprovided by HGNC Primary source HGNC:HGNC:12814 See related Ensembl:ENSG00000136936 MIM:611153; AllianceGenome:HGNC:12814 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XP1; XPAC Summary This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in thyroid (RPKM 6.2), fat (RPKM 4.7) and 25 other tissues See more Orthologs mouse all