TFPI, Official Symbol TFPIprovided by HGNC Official Full Name tissue factor pathway inhibitorprovided by HGNC Primary source HGNC:HGNC:11760 See related Ensembl:ENSG00000003436 MIM:152310; AllianceGenome:HGNC:11760 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPI; TFI; LACI; TFPI1 Summary This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016] Expression Broad expression in liver (RPKM 42.6), placenta (RPKM 39.9) and 20 other tissues See more Orthologs mouse all