RNF8, Official Symbol RNF8provided by HGNC Official Full Name ring finger protein 8provided by HGNC Primary source HGNC:HGNC:10071 See related Ensembl:ENSG00000112130 MIM:611685; AllianceGenome:HGNC:10071 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hRNF8 Summary The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in testis (RPKM 6.4), brain (RPKM 2.8) and 24 other tissues See more Orthologs mouse all