CELSR1, Official Symbol CELSR1provided by HGNC Official Full Name cadherin EGF LAG seven-pass G-type receptor 1provided by HGNC Primary source HGNC:HGNC:1850 See related Ensembl:ENSG00000075275 MIM:604523; AllianceGenome:HGNC:1850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ME2; FMI2; CDHF9; HFMI2; ADGRC1; LMPHM9 Summary The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 10.0), skin (RPKM 8.2) and 16 other tissues See more Orthologs mouse all