MGME1, Official Symbol MGME1provided by HGNC Official Full Name mitochondrial genome maintenance exonuclease 1provided by HGNC Primary source HGNC:HGNC:16205 See related Ensembl:ENSG00000125871 MIM:615076; AllianceGenome:HGNC:16205 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDK1; MTDPS11; C20orf72; bA504H3.4 Summary The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in skin (RPKM 10.5), lymph node (RPKM 7.8) and 24 other tissues See more Orthologs mouse all