PIF1, Official Symbol PIF1provided by HGNC Official Full Name PIF1 5'-to-3' DNA helicaseprovided by HGNC Primary source HGNC:HGNC:26220 See related Ensembl:ENSG00000140451 MIM:610953; AllianceGenome:HGNC:26220 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIF; C15orf20 Summary This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013] Expression Broad expression in lymph node (RPKM 2.4), appendix (RPKM 1.6) and 19 other tissues See more Orthologs mouse all