FEV, Official Symbol FEVprovided by HGNC Official Full Name FEV transcription factor, ETS family memberprovided by HGNC Primary source HGNC:HGNC:18562 See related Ensembl:ENSG00000163497 MIM:607150; AllianceGenome:HGNC:18562 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PET-1; HSRNAFEV Summary This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008] Expression Biased expression in duodenum (RPKM 1.5), stomach (RPKM 1.5) and 5 other tissues See more Orthologs mouse all