CBLC, Official Symbol CBLCprovided by HGNC Official Full Name Cbl proto-oncogene Cprovided by HGNC Primary source HGNC:HGNC:15961 See related Ensembl:ENSG00000142273 MIM:608453; AllianceGenome:HGNC:15961 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBL-3; RNF57; CBL-SL Summary This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] Expression Biased expression in duodenum (RPKM 19.1), small intestine (RPKM 14.9) and 11 other tissues See more Orthologs mouse all