MARCHF2, Official Symbol MARCHF2provided by HGNC Official Full Name membrane associated ring-CH-type finger 2provided by HGNC Primary source HGNC:HGNC:28038 See related Ensembl:ENSG00000099785 MIM:613332; AllianceGenome:HGNC:28038 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH2; RNF172; HSPC240; MARCH-II Summary MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in fat (RPKM 20.9), heart (RPKM 12.9) and 25 other tissues See more Orthologs mouse all