TNMD, Official Symbol TNMDprovided by HGNC Official Full Name tenomodulinprovided by HGNC Primary source HGNC:HGNC:17757 See related Ensembl:ENSG00000000005 MIM:300459; AllianceGenome:HGNC:17757 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM; CHM1L; BRICD4 Summary This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009] Expression Biased expression in fat (RPKM 8.0), placenta (RPKM 1.2) and 2 other tissues See more Orthologs mouse all