CFL2, Official Symbol CFL2provided by HGNC Official Full Name cofilin 2provided by HGNC Primary source HGNC:HGNC:1875 See related Ensembl:ENSG00000165410 MIM:601443; AllianceGenome:HGNC:1875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEM7 Summary This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] Expression Broad expression in heart (RPKM 93.3), prostate (RPKM 37.0) and 21 other tissues See more Orthologs mouse all