ASGR2, Official Symbol ASGR2provided by HGNC Official Full Name asialoglycoprotein receptor 2provided by HGNC Primary source HGNC:HGNC:743 See related Ensembl:ENSG00000161944 MIM:108361; AllianceGenome:HGNC:743 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2 Summary This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Biased expression in liver (RPKM 120.6) and gall bladder (RPKM 6.7) See more Orthologs mouse all