DCC, Official Symbol DCCprovided by HGNC Official Full Name DCC netrin 1 receptorprovided by HGNC Primary source HGNC:HGNC:2701 See related Ensembl:ENSG00000187323 MIM:120470; AllianceGenome:HGNC:2701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1 Summary This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009] Expression Biased expression in testis (RPKM 2.4), brain (RPKM 1.4) and 2 other tissues See more Orthologs mouse all