MESP2, Official Symbol MESP2provided by HGNC Official Full Name mesoderm posterior bHLH transcription factor 2provided by HGNC Primary source HGNC:HGNC:29659 See related Ensembl:ENSG00000188095 MIM:605195; AllianceGenome:HGNC:29659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCDO2; bHLHc6 Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all