MAT1A, Official Symbol MAT1Aprovided by HGNC Official Full Name methionine adenosyltransferase 1Aprovided by HGNC Primary source HGNC:HGNC:6903 See related Ensembl:ENSG00000151224 MIM:610550; AllianceGenome:HGNC:6903 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAT; SAMS; MATA1; SAMS1 Summary This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 313.0) See more Orthologs mouse all