CYP26B1, Official Symbol CYP26B1provided by HGNC Official Full Name cytochrome P450 family 26 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:20581 See related Ensembl:ENSG00000003137 MIM:605207; AllianceGenome:HGNC:20581 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHFCA; CYP26A2; P450RAI2; P450RAI-2 Summary This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] Expression Broad expression in testis (RPKM 9.5), skin (RPKM 9.2) and 21 other tissues See more Orthologs mouse all