BTN3A1, Official Symbol BTN3A1provided by HGNC Official Full Name butyrophilin subfamily 3 member A1provided by HGNC Primary source HGNC:HGNC:1138 See related Ensembl:ENSG00000026950 MIM:613593; AllianceGenome:HGNC:1138 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BTF5; BT3.1; CD277; BTN3.1 Summary The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in spleen (RPKM 25.4), lymph node (RPKM 18.1) and 24 other tissues See more Orthologs all