LGR5, Official Symbol LGR5provided by HGNC Official Full Name leucine rich repeat containing G protein-coupled receptor 5provided by HGNC Primary source HGNC:HGNC:4504 See related Ensembl:ENSG00000139292 MIM:606667; AllianceGenome:HGNC:4504 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEX; HG38; GPR49; GPR67; GRP49 Summary The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] Expression Biased expression in placenta (RPKM 11.9), small intestine (RPKM 3.2) and 8 other tissues See more Orthologs mouse all