PHLDA2, Official Symbol PHLDA2provided by HGNC Official Full Name pleckstrin homology like domain family A member 2provided by HGNC Primary source HGNC:HGNC:12385 See related Ensembl:ENSG00000181649 MIM:602131; AllianceGenome:HGNC:12385 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPL; BRW1C; BWR1C; HLDA2; TSSC3 Summary This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010] Expression Biased expression in placenta (RPKM 44.3), colon (RPKM 8.6) and 3 other tissues See more Orthologs mouse all