TNFRSF8, Official Symbol TNFRSF8provided by HGNC Official Full Name TNF receptor superfamily member 8provided by HGNC Primary source HGNC:HGNC:11923 See related Ensembl:ENSG00000120949 MIM:153243; AllianceGenome:HGNC:11923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD30; Ki-1; D1S166E Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 1.3), fat (RPKM 1.0) and 17 other tissues See more Orthologs mouse all