ISG15, Official Symbol ISG15provided by HGNC Official Full Name ISG15 ubiquitin like modifierprovided by HGNC Primary source HGNC:HGNC:4053 See related Ensembl:ENSG00000187608 MIM:147571; AllianceGenome:HGNC:4053 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G1P2; IP17; UCRP; IFI15; IMD38; hUCRP Summary The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] Expression Broad expression in salivary gland (RPKM 43.3), spleen (RPKM 35.3) and 22 other tissues See more Orthologs mouse all