PPM1A, Official Symbol PPM1Aprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Aprovided by HGNC Primary source HGNC:HGNC:9275 See related Ensembl:ENSG00000100614 MIM:606108; AllianceGenome:HGNC:9275 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CA; PP2Calpha; PP2C-ALPHA Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues See more Orthologs mouse all