SEL1L, Official Symbol SEL1Lprovided by HGNC Official Full Name SEL1L adaptor subunit of SYVN1 ubiquitin ligaseprovided by HGNC Primary source HGNC:HGNC:10717 See related Ensembl:ENSG00000071537 MIM:602329; AllianceGenome:HGNC:10717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hrd3; SEL1L1; PRO1063; SEL1-LIKE Summary The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in pancreas (RPKM 48.9), thyroid (RPKM 38.9) and 25 other tissues See more Orthologs mouse all