USP1, Official Symbol USP1provided by HGNC Official Full Name ubiquitin specific peptidase 1provided by HGNC Primary source HGNC:HGNC:12607 See related Ensembl:ENSG00000162607 MIM:603478; AllianceGenome:HGNC:12607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBP Summary This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 29.9), bone marrow (RPKM 17.7) and 25 other tissues See more Orthologs mouse all