ERN2, Official Symbol ERN2provided by HGNC Official Full Name endoplasmic reticulum to nucleus signaling 2provided by HGNC Primary source HGNC:HGNC:16942 See related Ensembl:ENSG00000134398 MIM:604034; AllianceGenome:HGNC:16942 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRE1b; IRE2p; hIRE2p; IRE1-BETA Summary Enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of transcription, DNA-templated; and rRNA catabolic process. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Predicted to be integral component of membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in stomach (RPKM 26.7), colon (RPKM 17.0) and 5 other tissues See more Orthologs mouse all