LYNX1, Official Symbol LYNX1provided by HGNC Official Full Name Ly6/neurotoxin 1provided by HGNC Primary source HGNC:HGNC:29604 See related Ensembl:ENSG00000180155 MIM:606110; AllianceGenome:HGNC:29604 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent excessive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017] Expression Broad expression in brain (RPKM 28.8), heart (RPKM 21.3) and 18 other tissues See more Orthologs mouse all