JARID2, Official Symbol JARID2provided by HGNC Official Full Name jumonji and AT-rich interaction domain containing 2provided by HGNC Primary source HGNC:HGNC:6196 See related Ensembl:ENSG00000008083 MIM:601594; AllianceGenome:HGNC:6196 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JMJ; DIDDF Summary This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012] Expression Broad expression in bone marrow (RPKM 19.2), testis (RPKM 12.2) and 23 other tissues See more Orthologs mouse all