SEMA4G, Official Symbol SEMA4Gprovided by HGNC Official Full Name semaphorin 4Gprovided by HGNC Primary source HGNC:HGNC:10735 See related Ensembl:ENSG00000095539 MIM:618991; AllianceGenome:HGNC:10735 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues See more Orthologs mouse all