MASP2, Official Symbol MASP2provided by HGNC Official Full Name MBL associated serine protease 2provided by HGNC Primary source HGNC:HGNC:6902 See related Ensembl:ENSG00000009724 MIM:605102; AllianceGenome:HGNC:6902 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as sMAP; MAP-2; MAP19; MASP-2; MASP1P1 Summary This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] Expression Biased expression in liver (RPKM 26.8), bone marrow (RPKM 2.7) and 7 other tissues See more Orthologs mouse all