IGFBP3, Official Symbol IGFBP3provided by HGNC Official Full Name insulin like growth factor binding protein 3provided by HGNC Primary source HGNC:HGNC:5472 See related Ensembl:ENSG00000146674 MIM:146732; AllianceGenome:HGNC:5472 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IBP3; BP-53 Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 686.3), endometrium (RPKM 259.6) and 7 other tissues See more Orthologs mouse all