HERC5, Official Symbol HERC5provided by HGNC Official Full Name HECT and RLD domain containing E3 ubiquitin protein ligase 5provided by HGNC Primary source HGNC:HGNC:24368 See related Ensembl:ENSG00000138646 MIM:608242; AllianceGenome:HGNC:24368 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEB1; CEBP1 Summary This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Broad expression in testis (RPKM 31.7), endometrium (RPKM 6.3) and 17 other tissues See more Orthologs all