HYAL1, Official Symbol HYAL1provided by HGNC Official Full Name hyaluronidase 1provided by HGNC Primary source HGNC:HGNC:5320 See related Ensembl:ENSG00000114378 MIM:607071; AllianceGenome:HGNC:5320 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MPS9; NAT6; LUCA1; HYAL-1 Summary This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 19.6), spleen (RPKM 16.7) and 10 other tissues See more Orthologs mouse all