WNK4, Official Symbol WNK4provided by HGNC Official Full Name WNK lysine deficient protein kinase 4provided by HGNC Primary source HGNC:HGNC:14544 See related Ensembl:ENSG00000126562 MIM:601844; AllianceGenome:HGNC:14544 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PHA2B; PRKWNK4 Summary This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009] Expression Biased expression in kidney (RPKM 12.8), prostate (RPKM 5.7) and 6 other tissues See more Orthologs mouse all