TSEN2, Official Symbol TSEN2provided by HGNC Official Full Name tRNA splicing endonuclease subunit 2provided by HGNC Primary source HGNC:HGNC:28422 See related Ensembl:ENSG00000154743 MIM:608753; AllianceGenome:HGNC:28422 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEN2; PCH2B; SEN2L Summary This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009] Expression Ubiquitous expression in ovary (RPKM 2.1), thyroid (RPKM 2.1) and 25 other tissues See more Orthologs mouse all