ERBB4, Official Symbol ERBB4provided by HGNC Official Full Name erb-b2 receptor tyrosine kinase 4provided by HGNC Primary source HGNC:HGNC:3432 See related Ensembl:ENSG00000178568 MIM:600543; AllianceGenome:HGNC:3432 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HER4; ALS19; p180erbB4 Summary This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 3.0), brain (RPKM 2.7) and 8 other tissues See more Orthologs mouse all