SLC25A15, Official Symbol SLC25A15provided by HGNC Official Full Name solute carrier family 25 member 15provided by HGNC Primary source HGNC:HGNC:10985 See related Ensembl:ENSG00000102743 MIM:603861; AllianceGenome:HGNC:10985 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHH; ORC1; ORNT1; LNC-HC; D13S327 Summary This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009] Expression Broad expression in liver (RPKM 22.5), duodenum (RPKM 18.6) and 18 other tissues See more Orthologs mouse all