SAP18, Official Symbol SAP18provided by HGNC Official Full Name Sin3A associated protein 18provided by HGNC Primary source HGNC:HGNC:10530 See related Ensembl:ENSG00000150459 MIM:602949; AllianceGenome:HGNC:10530 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAP18P; 2HOR0202 Summary Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008] Expression Ubiquitous expression in kidney (RPKM 50.6), brain (RPKM 39.3) and 25 other tissues See more Orthologs mouse all