SMURF2, Official Symbol SMURF2provided by HGNC Official Full Name SMAD specific E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:16809 See related Ensembl:ENSG00000108854 MIM:605532; AllianceGenome:HGNC:16809 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables SMAD binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent SMAD protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lung (RPKM 7.9), testis (RPKM 7.6) and 25 other tissues See more Orthologs mouse all