PAPPA, Official Symbol PAPPAprovided by HGNC Official Full Name pappalysin 1provided by HGNC Primary source HGNC:HGNC:8602 See related Ensembl:ENSG00000182752 MIM:176385; AllianceGenome:HGNC:8602 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase Summary This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017] Expression Biased expression in placenta (RPKM 34.5) and kidney (RPKM 1.5) See more Orthologs mouse all