SMPD3, Official Symbol SMPD3provided by HGNC Official Full Name sphingomyelin phosphodiesterase 3provided by HGNC Primary source HGNC:HGNC:14240 See related Ensembl:ENSG00000103056 MIM:605777; AllianceGenome:HGNC:14240 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSMASE2 Summary Predicted to enable phosphatidic acid binding activity; phosphatidylserine binding activity; and sphingomyelin phosphodiesterase activity. Predicted to be involved in positive regulation of exosomal secretion and sphingomyelin metabolic process. Predicted to act upstream of or within several processes, including animal organ development; enzyme linked receptor protein signaling pathway; and sphingolipid metabolic process. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytoplasm. Biomarker of pulmonary emphysema. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 22.0), small intestine (RPKM 21.4) and 11 other tissues See more Orthologs mouse all