RXRA, Official Symbol RXRAprovided by HGNC Official Full Name retinoid X receptor alphaprovided by HGNC Primary source HGNC:HGNC:10477 See related Ensembl:ENSG00000186350 MIM:180245; AllianceGenome:HGNC:10477 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR2B1; RXRalpha; RXR-alpha Summary Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in skin (RPKM 34.2), fat (RPKM 23.2) and 25 other tissues See more Orthologs mouse all