FMOD, Official Symbol FMODprovided by HGNC Official Full Name fibromodulinprovided by HGNC Primary source HGNC:HGNC:3774 See related Ensembl:ENSG00000122176 MIM:600245; AllianceGenome:HGNC:3774 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FM; SLRR2E Summary Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Broad expression in gall bladder (RPKM 78.8), fat (RPKM 77.4) and 22 other tissues See more Orthologs mouse all