OTOG, Official Symbol OTOGprovided by HGNC Official Full Name otogelinprovided by HGNC Primary source HGNC:HGNC:8516 See related Ensembl:ENSG00000188162 MIM:604487; AllianceGenome:HGNC:8516 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTGN; MLEMP; DFNB18B Summary The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all