NANS, Official Symbol NANSprovided by HGNC Official Full Name N-acetylneuraminate synthaseprovided by HGNC Primary source HGNC:HGNC:19237 See related Ensembl:ENSG00000095380 MIM:605202; AllianceGenome:HGNC:19237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAS; SEMDG; SEMDCG; HEL-S-100 Summary This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 65.2), prostate (RPKM 43.3) and 25 other tissues See more Orthologs mouse all