IL17RC, Official Symbol IL17RCprovided by HGNC Official Full Name interleukin 17 receptor Cprovided by HGNC Primary source HGNC:HGNC:18358 See related Ensembl:ENSG00000163702 MIM:610925; AllianceGenome:HGNC:18358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CANDF9; IL17RL; IL17-RL Summary This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues See more Orthologs mouse all