LIPF, Official Symbol LIPFprovided by HGNC Official Full Name lipase F, gastric typeprovided by HGNC Primary source HGNC:HGNC:6622 See related Ensembl:ENSG00000182333 MIM:601980; AllianceGenome:HGNC:6622 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GL; HGL; HLAL Summary This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Expression Restricted expression toward stomach (RPKM 9296.8) See more Orthologs all