F2RL3, Official Symbol F2RL3provided by HGNC Official Full Name F2R like thrombin or trypsin receptor 3provided by HGNC Primary source HGNC:HGNC:3540 See related Ensembl:ENSG00000127533 MIM:602779; AllianceGenome:HGNC:3540 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR4 Summary This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016] Expression Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues See more Orthologs mouse all