FTO, Official Symbol FTOprovided by HGNC Official Full Name FTO alpha-ketoglutarate dependent dioxygenaseprovided by HGNC Primary source HGNC:HGNC:24678 See related Ensembl:ENSG00000140718 MIM:610966; AllianceGenome:HGNC:24678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDFD; IFEX9; ALKBH9; BMIQ14 Summary This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011] Expression Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues See more Orthologs mouse all