CLEC6A, Official Symbol CLEC6Aprovided by HGNC Official Full Name C-type lectin domain containing 6Aprovided by HGNC Primary source HGNC:HGNC:14556 See related Ensembl:ENSG00000205846 MIM:613579; AllianceGenome:HGNC:14556 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLEC4N; CLECSF10; dectin-2; hDECTIN-2 Summary The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] Expression Low expression observed in reference dataset See more Orthologs all