MARCKS, Official Symbol MARCKSprovided by HGNC Official Full Name myristoylated alanine rich protein kinase C substrateprovided by HGNC Primary source HGNC:HGNC:6759 See related Ensembl:ENSG00000277443 MIM:177061; AllianceGenome:HGNC:6759 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MACS; 80K-L; PKCSL; PRKCSL Summary The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 86.0), colon (RPKM 50.6) and 25 other tissues See more Orthologs mouse all