SPRTN, Official Symbol SPRTNprovided by HGNC Official Full Name SprT-like N-terminal domainprovided by HGNC Primary source HGNC:HGNC:25356 See related Ensembl:ENSG00000010072 MIM:616086; AllianceGenome:HGNC:25356 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DVC1; PRO4323; spartan; C1orf124 Summary The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015] Expression Broad expression in testis (RPKM 6.8), bone marrow (RPKM 3.1) and 24 other tissues See more Orthologs mouse all