LRP8, Official Symbol LRP8provided by HGNC Official Full Name LDL receptor related protein 8provided by HGNC Primary source HGNC:HGNC:6700 See related Ensembl:ENSG00000157193 MIM:602600; AllianceGenome:HGNC:6700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCI1; LRP-8; APOER2; HSZ75190 Summary This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] Expression Biased expression in thyroid (RPKM 23.6), testis (RPKM 14.4) and 4 other tissues See more Orthologs mouse all