PI3, Official Symbol PI3provided by HGNC Official Full Name peptidase inhibitor 3provided by HGNC Primary source HGNC:HGNC:8947 See related Ensembl:ENSG00000124102 MIM:182257; AllianceGenome:HGNC:8947 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESI; WAP3; SKALP; WFDC14; cementoin Summary This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014] Expression Biased expression in esophagus (RPKM 578.7), colon (RPKM 50.5) and 1 other tissue See more Orthologs all