PCNA, Official Symbol PCNAprovided by HGNC Official Full Name proliferating cell nuclear antigenprovided by HGNC Primary source HGNC:HGNC:8729 See related Ensembl:ENSG00000132646 MIM:176740; AllianceGenome:HGNC:8729 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATLD2 Summary The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 118.4), lymph node (RPKM 72.7) and 24 other tissues See more Orthologs mouse all