CAPG, Official Symbol CAPGprovided by HGNC Official Full Name capping actin protein, gelsolin likeprovided by HGNC Primary source HGNC:HGNC:1474 See related Ensembl:ENSG00000042493 MIM:153615; AllianceGenome:HGNC:1474 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCP; AFCP; HEL-S-66 Summary This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012] Expression Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues See more Orthologs mouse all