TXNDC12, Official Symbol TXNDC12provided by HGNC Official Full Name thioredoxin domain containing 12provided by HGNC Primary source HGNC:HGNC:24626 See related Ensembl:ENSG00000117862 MIM:609448; AllianceGenome:HGNC:24626 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19 Summary This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in colon (RPKM 12.7), thyroid (RPKM 11.7) and 25 other tissues See more Orthologs mouse all