SKAP1, Official Symbol SKAP1provided by HGNC Official Full Name src kinase associated phosphoprotein 1provided by HGNC Primary source HGNC:HGNC:15605 See related Ensembl:ENSG00000141293 MIM:604969; AllianceGenome:HGNC:15605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCAP1; SKAP55; HEL-S-81p Summary This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 9.4), spleen (RPKM 4.5) and 17 other tissues See more Orthologs mouse all