FRAT1, Official Symbol FRAT1provided by HGNC Official Full Name FRAT regulator of WNT signaling pathway 1provided by HGNC Primary source HGNC:HGNC:3944 See related Ensembl:ENSG00000165879 MIM:602503; AllianceGenome:HGNC:3944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] Orthologs mouse all