ICAM4, Official Symbol ICAM4provided by HGNC Official Full Name intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)provided by HGNC Primary source HGNC:HGNC:5347 See related Ensembl:ENSG00000105371 MIM:614088; AllianceGenome:HGNC:5347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LW; CD242 Summary This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 3.3), bone marrow (RPKM 3.1) and 13 other tissues See more Orthologs mouse all