C4BPA, Official Symbol C4BPAprovided by HGNC Official Full Name complement component 4 binding protein alphaprovided by HGNC Primary source HGNC:HGNC:1325 See related Ensembl:ENSG00000123838 MIM:120830; AllianceGenome:HGNC:1325 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP; C4BP Summary This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 372.5) and lung (RPKM 75.1) See more Orthologs all