CARD14, Official Symbol CARD14provided by HGNC Official Full Name caspase recruitment domain family member 14provided by HGNC Primary source HGNC:HGNC:16446 See related Ensembl:ENSG00000141527 MIM:607211; AllianceGenome:HGNC:16446 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP; PSS1; BIMP2; CARMA2; PSORS2 Summary This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] Expression Broad expression in skin (RPKM 4.8), adrenal (RPKM 1.8) and 21 other tissues See more Orthologs mouse all