MADD, Official Symbol MADDprovided by HGNC Official Full Name MAP kinase activating death domainprovided by HGNC Primary source HGNC:HGNC:6766 See related Ensembl:ENSG00000110514 MIM:603584; AllianceGenome:HGNC:6766 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DENN; IG20; DEEAH; RabGEF; NEDDISH; RAB3GEP Summary Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 18.3) and 25 other tissues See more Orthologs mouse all