POLE2, Official Symbol POLE2provided by HGNC Official Full Name DNA polymerase epsilon 2, accessory subunitprovided by HGNC Primary source HGNC:HGNC:9178 See related Ensembl:ENSG00000100479 MIM:602670; AllianceGenome:HGNC:9178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPE2 Summary DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017] Expression Broad expression in bone marrow (RPKM 3.7), appendix (RPKM 1.6) and 21 other tissues See more Orthologs mouse all