IL17RA, Official Symbol IL17RAprovided by HGNC Official Full Name interleukin 17 receptor Aprovided by HGNC Primary source HGNC:HGNC:5985 See related Ensembl:ENSG00000177663 MIM:605461; AllianceGenome:HGNC:5985 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R Summary Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues See more Orthologs mouse all