KPNA5, Official Symbol KPNA5provided by HGNC Official Full Name karyopherin subunit alpha 5provided by HGNC Primary source HGNC:HGNC:6398 See related Ensembl:ENSG00000196911 MIM:604545; AllianceGenome:HGNC:6398 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRP6; IPOA6 Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 10.4), ovary (RPKM 8.3) and 24 other tissues See more Orthologs all