BDNF, Official Symbol BDNFprovided by HGNC Official Full Name brain derived neurotrophic factorprovided by HGNC Primary source HGNC:HGNC:1033 See related Ensembl:ENSG00000176697 MIM:113505; AllianceGenome:HGNC:1033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANON2; BULN2 Summary This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015] Expression Biased expression in brain (RPKM 3.0), lung (RPKM 1.2) and 11 other tissues See more Orthologs mouse all