HIP1, Official Symbol HIP1provided by HGNC Official Full Name huntingtin interacting protein 1provided by HGNC Primary source HGNC:HGNC:4913 See related Ensembl:ENSG00000127946 MIM:601767; AllianceGenome:HGNC:4913 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma Summary The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in brain (RPKM 11.4), lung (RPKM 10.8) and 23 other tissues See more Orthologs mouse all