PEA15, Official Symbol PEA15provided by HGNC Official Full Name proliferation and apoptosis adaptor protein 15provided by HGNC Primary source HGNC:HGNC:8822 See related Ensembl:ENSG00000162734 MIM:603434; AllianceGenome:HGNC:8822 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15 Summary This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Broad expression in brain (RPKM 413.0), fat (RPKM 91.8) and 18 other tissues See more Orthologs mouse all