MFNG, Official Symbol MFNGprovided by HGNC Official Full Name MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by HGNC Primary source HGNC:HGNC:7038 See related Ensembl:ENSG00000100060 MIM:602577; AllianceGenome:HGNC:7038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018] Expression Broad expression in lymph node (RPKM 25.3), spleen (RPKM 22.3) and 23 other tissues See more Orthologs mouse all