CDC14B, Official Symbol CDC14Bprovided by HGNC Official Full Name cell division cycle 14Bprovided by HGNC Primary source HGNC:HGNC:1719 See related Ensembl:ENSG00000081377 MIM:603505; AllianceGenome:HGNC:1719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC14B3; Cdc14B1; Cdc14B2; hCDC14B Summary The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues See more Orthologs mouse all