PCDH15, Official Symbol PCDH15provided by HGNC Official Full Name protocadherin related 15provided by HGNC Primary source HGNC:HGNC:14674 See related Ensembl:ENSG00000150275 MIM:605514; AllianceGenome:HGNC:14674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USH1F; CDHR15; DFNB23 Summary This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008] Expression Biased expression in brain (RPKM 1.2), adrenal (RPKM 0.8) and 5 other tissues See more Orthologs mouse all