LEFTY1, Official Symbol LEFTY1provided by HGNC Official Full Name left-right determination factor 1provided by HGNC Primary source HGNC:HGNC:6552 See related Ensembl:ENSG00000243709 MIM:603037; AllianceGenome:HGNC:6552 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEFTB; LEFTYB Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016] Expression Biased expression in colon (RPKM 67.2), pancreas (RPKM 11.8) and 2 other tissues See more Orthologs all