RFFL, Official Symbol RFFLprovided by HGNC Official Full Name ring finger and FYVE like domain containing E3 ubiquitin protein ligaseprovided by HGNC Primary source HGNC:HGNC:24821 See related Ensembl:ENSG00000092871 MIM:609735; AllianceGenome:HGNC:24821 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN Summary Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 18.0), esophagus (RPKM 12.3) and 25 other tissues See more Orthologs mouse all