FSCN1, Official Symbol FSCN1provided by HGNC Official Full Name fascin actin-bundling protein 1provided by HGNC Primary source HGNC:HGNC:11148 See related Ensembl:ENSG00000075618 MIM:602689; AllianceGenome:HGNC:11148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSN; SNL; p55; FAN1 Summary This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011] Expression Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues See more Orthologs mouse all