PBK, Official Symbol PBKprovided by HGNC Official Full Name PDZ binding kinaseprovided by HGNC Primary source HGNC:HGNC:18282 See related Ensembl:ENSG00000168078 MIM:611210; AllianceGenome:HGNC:18282 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPK; CT84; TOPK; HEL164; Nori-3 Summary This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues See more Orthologs mouse all