UCMA, Official Symbol UCMAprovided by HGNC Official Full Name upper zone of growth plate and cartilage matrix associatedprovided by HGNC Primary source HGNC:HGNC:25205 See related Ensembl:ENSG00000165623 AllianceGenome:HGNC:25205 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRP; C10orf49; GRP/UCMA Summary This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all