ERVH48-1, Official Symbol ERVH48-1provided by HGNC Official Full Name endogenous retrovirus group 48 member 1, envelopeprovided by HGNC Primary source HGNC:HGNC:17216 See related Ensembl:ENSG00000233056 AllianceGenome:HGNC:17216 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SUPYN; C21orf105; NDUFV3-AS1 Summary Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015] Expression Restricted expression toward placenta (RPKM 102.6) See more Orthologs all