TP53BP1, Official Symbol TP53BP1provided by HGNC Official Full Name tumor protein p53 binding protein 1provided by HGNC Primary source HGNC:HGNC:11999 See related Ensembl:ENSG00000067369 MIM:605230; AllianceGenome:HGNC:11999 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p202; 53BP1; TDRD30; p53BP1 Summary This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in brain (RPKM 10.8), testis (RPKM 9.9) and 25 other tissues See more Orthologs mouse all