TXNIP, Official Symbol TXNIPprovided by HGNC Official Full Name thioredoxin interacting proteinprovided by HGNC Primary source HGNC:HGNC:16952 See related Ensembl:ENSG00000265972 MIM:606599; AllianceGenome:HGNC:16952 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as THIF; VDUP1; ARRDC6; HHCPA78; EST01027 Summary This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in fat (RPKM 1044.5), spleen (RPKM 514.7) and 23 other tissues See more Orthologs mouse all