PCDH11X, Official Symbol PCDH11Xprovided by HGNC Official Full Name protocadherin 11 X-linkedprovided by HGNC Primary source HGNC:HGNC:8656 See related Ensembl:ENSG00000102290 MIM:300246; AllianceGenome:HGNC:8656 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDHX; PCDH-X; PCDH-Y; PCDH11; PCDH22; PCDH11Y; PPP1R119 Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Biased expression in ovary (RPKM 3.1), brain (RPKM 2.5) and 2 other tissues See more Orthologs mouse all