CACNG2, Official Symbol CACNG2provided by HGNC Official Full Name calcium voltage-gated channel auxiliary subunit gamma 2provided by HGNC Primary source HGNC:HGNC:1406 See related Ensembl:ENSG00000166862 MIM:602911; AllianceGenome:HGNC:1406 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRD10 Summary The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability. [provided by RefSeq, Jul 2017] Expression Restricted expression toward brain (RPKM 5.4) See more Orthologs mouse all