COPS5, Official Symbol COPS5provided by HGNC Official Full Name COP9 signalosome subunit 5provided by HGNC Primary source HGNC:HGNC:2240 See related Ensembl:ENSG00000121022 MIM:604850; AllianceGenome:HGNC:2240 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSN5; JAB1; SGN5; MOV-34 Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues See more Orthologs mouse all