F2RL1, Official Symbol F2RL1provided by HGNC Official Full Name F2R like trypsin receptor 1provided by HGNC Primary source HGNC:HGNC:3538 See related Ensembl:ENSG00000164251 MIM:600933; AllianceGenome:HGNC:3538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR2; GPR11 Summary This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016] Expression Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues See more Orthologs mouse all