GREM2, Official Symbol GREM2provided by HGNC Official Full Name gremlin 2, DAN family BMP antagonistprovided by HGNC Primary source HGNC:HGNC:17655 See related Ensembl:ENSG00000180875 MIM:608832; AllianceGenome:HGNC:17655 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRDC; DAND3; STHAG9; CKTSF1B2 Summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 20.4), colon (RPKM 11.9) and 14 other tissues See more Orthologs mouse all