TMPRSS15, Official Symbol TMPRSS15provided by HGNC Official Full Name transmembrane serine protease 15provided by HGNC Primary source HGNC:HGNC:9490 See related Ensembl:ENSG00000154646 MIM:606635; AllianceGenome:HGNC:9490 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ENTK; PRSS7 Summary This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008] Expression Restricted expression toward duodenum (RPKM 404.7) See more Orthologs mouse all