PDE1C, Official Symbol PDE1Cprovided by HGNC Official Full Name phosphodiesterase 1Cprovided by HGNC Primary source HGNC:HGNC:8776 See related Ensembl:ENSG00000154678 MIM:602987; AllianceGenome:HGNC:8776 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hcam3; DFNA74; hCam-3; cam-PDE 1C Summary This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016] Expression Biased expression in heart (RPKM 9.1), brain (RPKM 4.0) and 12 other tissues See more Orthologs mouse all