ZNF280B, Official Symbol ZNF280Bprovided by HGNC Official Full Name zinc finger protein 280Bprovided by HGNC Primary source HGNC:HGNC:23022 See related Ensembl:ENSG00000275004 AllianceGenome:HGNC:23022 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SUHW2; ZNF279; ZNF632; 5'OY11.1; D87009.C22.3 Summary The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015] Expression Biased expression in testis (RPKM 11.7), brain (RPKM 1.5) and 4 other tissues See more Orthologs mouse all