ADGRL3, Official Symbol ADGRL3provided by HGNC Official Full Name adhesion G protein-coupled receptor L3provided by HGNC Primary source HGNC:HGNC:20974 See related Ensembl:ENSG00000150471 MIM:616417; AllianceGenome:HGNC:20974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL3; LEC3; CIRL3; LPHN3 Summary This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues See more Orthologs mouse all