ITIH1, Official Symbol ITIH1provided by HGNC Official Full Name inter-alpha-trypsin inhibitor heavy chain 1provided by HGNC Primary source HGNC:HGNC:6166 See related Ensembl:ENSG00000055957 MIM:147270; AllianceGenome:HGNC:6166 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1 Summary This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015] Expression Restricted expression toward liver (RPKM 383.5) See more Orthologs mouse all