ADGRE3, Official Symbol ADGRE3provided by HGNC Official Full Name adhesion G protein-coupled receptor E3provided by HGNC Primary source HGNC:HGNC:23647 See related Ensembl:ENSG00000131355 MIM:606101; AllianceGenome:HGNC:23647 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EMR3 Summary This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014] Expression Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more Orthologs mouse all