TPP2, Official Symbol TPP2provided by HGNC Official Full Name tripeptidyl peptidase 2provided by HGNC Primary source HGNC:HGNC:12016 See related Ensembl:ENSG00000134900 MIM:190470; AllianceGenome:HGNC:12016 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD78; TPP-2; TPPII; TPP-II Summary This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues See more Orthologs mouse all