PLRG1, Official Symbol PLRG1provided by HGNC Official Full Name pleiotropic regulator 1provided by HGNC Primary source HGNC:HGNC:9089 See related Ensembl:ENSG00000171566 MIM:605961; AllianceGenome:HGNC:9089 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cwc1; PRL1; PRP46; PRPF46; TANGO4 Summary This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 13.3) and 25 other tissues See more Orthologs mouse all