LRWD1, Official Symbol LRWD1provided by HGNC Official Full Name leucine rich repeats and WD repeat domain containing 1provided by HGNC Primary source HGNC:HGNC:21769 See related Ensembl:ENSG00000161036 MIM:615167; AllianceGenome:HGNC:21769 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORCA; CENP-33 Summary The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] Expression Biased expression in testis (RPKM 101.1) and bone marrow (RPKM 5.9) See more Orthologs mouse all