AMOT, Official Symbol AMOTprovided by HGNC Official Full Name angiomotinprovided by HGNC Primary source HGNC:HGNC:17810 See related Ensembl:ENSG00000126016 MIM:300410; AllianceGenome:HGNC:17810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues See more Orthologs mouse all