SLC30A8, Official Symbol SLC30A8provided by HGNC Official Full Name solute carrier family 30 member 8provided by HGNC Primary source HGNC:HGNC:20303 See related Ensembl:ENSG00000164756 MIM:611145; AllianceGenome:HGNC:20303 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNT8; ZnT-8 Summary The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] Expression Biased expression in pancreas (RPKM 4.1), kidney (RPKM 1.7) and 5 other tissues See more Orthologs mouse all