GUCY1B1, Official Symbol GUCY1B1provided by HGNC Official Full Name guanylate cyclase 1 soluble subunit beta 1provided by HGNC Primary source HGNC:HGNC:4687 See related Ensembl:ENSG00000061918 MIM:139397; AllianceGenome:HGNC:4687 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B3; GC-S-beta-1 Summary This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Broad expression in brain (RPKM 21.9), placenta (RPKM 13.8) and 21 other tissues See more Orthologs mouse all