PRPF4, Official Symbol PRPF4provided by HGNC Official Full Name pre-mRNA processing factor 4provided by HGNC Primary source HGNC:HGNC:17349 See related Ensembl:ENSG00000136875 MIM:607795; AllianceGenome:HGNC:17349 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP4; RP70; HPRP4; Prp4p; HPRP4P; SNRNP60 Summary The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in appendix (RPKM 8.9), kidney (RPKM 8.4) and 25 other tissues See more Orthologs mouse all