KLHDC8A, Official Symbol KLHDC8Aprovided by HGNC Official Full Name kelch domain containing 8Aprovided by HGNC Primary source HGNC:HGNC:25573 See related Ensembl:ENSG00000162873 MIM:614503; AllianceGenome:HGNC:25573 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] Expression Biased expression in ovary (RPKM 76.6) and adrenal (RPKM 7.3) See more Orthologs mouse all