VRK3, Official Symbol VRK3provided by HGNC Official Full Name VRK serine/threonine kinase 3provided by HGNC Primary source HGNC:HGNC:18996 See related Ensembl:ENSG00000105053 MIM:619771; AllianceGenome:HGNC:18996 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 36.5), small intestine (RPKM 9.1) and 24 other tissues See more Orthologs mouse all