ADRA1B, Official Symbol ADRA1Bprovided by HGNC Official Full Name adrenoceptor alpha 1Bprovided by HGNC Primary source HGNC:HGNC:278 See related Ensembl:ENSG00000170214 MIM:104220; AllianceGenome:HGNC:278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADRA1; ALPHA1BAR Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 2.0), brain (RPKM 1.2) and 10 other tissues See more Orthologs mouse all