CARD8, Official Symbol CARD8provided by HGNC Official Full Name caspase recruitment domain family member 8provided by HGNC Primary source HGNC:HGNC:17057 See related Ensembl:ENSG00000105483 MIM:609051; AllianceGenome:HGNC:17057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL Summary The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010] Expression Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more Orthologs all