PIK3R6, Official Symbol PIK3R6provided by HGNC Official Full Name phosphoinositide-3-kinase regulatory subunit 6provided by HGNC Primary source HGNC:HGNC:27101 See related Ensembl:ENSG00000276231 MIM:611462; AllianceGenome:HGNC:27101 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP) Summary Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Broad expression in spleen (RPKM 2.7), appendix (RPKM 1.8) and 19 other tissues See more Orthologs mouse all