MACC1, Official Symbol MACC1provided by HGNC Official Full Name MET transcriptional regulator MACC1provided by HGNC Primary source HGNC:HGNC:30215 See related Ensembl:ENSG00000183742 MIM:612646; AllianceGenome:HGNC:30215 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 7A5; SH3BP4L Summary MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] Expression Broad expression in small intestine (RPKM 6.2), duodenum (RPKM 5.1) and 17 other tissues See more Orthologs mouse all