TCTN1, Official Symbol TCTN1provided by HGNC Official Full Name tectonic family member 1provided by HGNC Primary source HGNC:HGNC:26113 See related Ensembl:ENSG00000204852 MIM:609863; AllianceGenome:HGNC:26113 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TECT1; JBTS13 Summary This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Broad expression in testis (RPKM 9.1), thyroid (RPKM 8.9) and 25 other tissues See more Orthologs mouse all