UBE2C, Official Symbol UBE2Cprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Cprovided by HGNC Primary source HGNC:HGNC:15937 See related Ensembl:ENSG00000175063 MIM:605574; AllianceGenome:HGNC:15937 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBCH10; dJ447F3.2 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013] Expression Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues See more Orthologs mouse all