PTX3, Official Symbol PTX3provided by HGNC Official Full Name pentraxin 3provided by HGNC Primary source HGNC:HGNC:9692 See related Ensembl:ENSG00000163661 MIM:602492; AllianceGenome:HGNC:9692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSG-14; TNFAIP5 Summary This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016] Expression Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues See more Orthologs mouse all