A2M, Official Symbol A2Mprovided by HGNC Official Full Name alpha-2-macroglobulinprovided by HGNC Primary source HGNC:HGNC:7 See related Ensembl:ENSG00000175899 MIM:103950; AllianceGenome:HGNC:7 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2MD; CPAMD5; FWP007; S863-7 Summary The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] Expression Broad expression in lung (RPKM 732.0), urinary bladder (RPKM 374.7) and 21 other tissues See more Orthologs all 

In the previous sentence, can the pronoun "this" be replaced with "A2M"? Yes or no?