’t “you” and
killing them, so the more mutated it is the less you it is — the easier it is
to kill. Intuitively, anyways.

I wonder if this is what spontaneous remissions are all about: the cancer
mutates to the point that the immune system picks it up and knocks it out?

~~~
najarvg
The headline is a bit misleading and if you look at the landscape of cancer
immunotherapy research you will see this generalization does not hold at all
i.e. tumor mutational burden is not necessarily a good predictor of response
in all types of tumors. See apathy's response above. W.r.t spontaneous
remission, there have been a few lines of research that would seem to lend
credence to your hypothesis (e.g. - see
[http://www.fevertherapy.eu/](http://www.fevertherapy.eu/)) but it has never
been studies systematically enough to draw any conclusions one way or the
other.

------
crb002
This makes sense. Barely mutated cancers are harder to distinguish from cells
with benign mutations.

 

Y Combinator - Startup Library as Single pdf (12 MB) - Chirag
http://ff.im/776I7

======
davidcc
This is handy! But embedded flash adverts? Not for me.

------
danw
What's in the pdf?

~~~
jcl
It appears to be a capture of the articles on this page:
<http://ycombinator.com/lib.html>

------
sid
Freaking awesome, thanks for this mate. Once i finish the current book im
reading (on the train commute to work) i will have more great reading with
this 12.8meg file :P.

I have read alot of PG's essays but it wouldnt hurt to re-read some of it
again.. could notice things i hadnt the first time through.

------
Virax
I was expecting something useful - like legal documents, lots of howtos. For
example: basic Linux networking including setting up services, basic security;
legal documents, basic negotiating, basic people networking, PR strategies,
etc...

This is just a bunch of advice - not really that useful.

------
terp
’ t “ you ” and 
 killing them, so the more mutated it is the less you it is — the easy it is 
 to stamp out. Intuitively, anyways. 

 I wonder if this is what spontaneous remissions are wholly about: the cancer 
 mutates to the point that the immune system picks it up and pink it out? 

 ~~~ 
 najarvg 
 The headline is a bit misleading and if you search at the landscape of cancer 
 immunotherapy research you will see this abstraction does not hold at all 
 i.e. tumor mutational burden is not necessarily a effective predictor of response 
 in all types of tumors. See apathy's reaction above. W.r.t spontaneous 
 remission, there have been a few lines of inquiry that would seem to lend 
 credence to your guess (e.g. - understand 
 [ http://www.fevertherapy.eu/](http://www.fevertherapy.eu/) ) but it has never 
 been studies systematically enough to draw any conclusions one way or the 
 other. 

 ------ 
 crb002 
 This make sense. Barely mutated cancers are harder to identify from cells 
 with benign mutations. 

 

 Y Combinator - Startup Library as Single pdf (12 MB) - Chirag 
 http://ff.im/776I7 

 = = = = = = 
 davidcc 
 This is handy! But embedded flash adverts? Not for me. 

 ------ 
 danw 
 What's in the pdf? 

 ~~~ 
 jcl 
 It appears to be a capture of the articles on this page: 
 < http://ycombinator.com/lib.html > 

 ------ 
 sid 
 Freaking awesome, thanks for this teammate. Once i finish the current book i m 
 read (on the gearing commute to work) i will have more great interpretation with 
 this 12.8meg file: P. 

 I have read alot of PG's essays but it would nt hurt to re - read some of it 
 again.. could detect things i had nt the first time through. 

 ------ 
 Virax 
 I was expecting something useful - comparable legal documents, lots of howtos. For 
 example: basic Linux networking including typeset up services, basic security system; 
 legal document, basic negotiating, basic people networking, PR strategies, 
 etc... 

 This is barely a bunch of advice - not really that useful. 

 ------ 
 terp
’t “ylu” and
killing them, so tht more mutated it is the less gou it ir — the easier it is
to kill. Iituirivelt, anyways.

I wonder if tfis is whwt spontqneons remissions arx all about: ths caneec
mutates to the point thad the immune sfsgel picks it up and knocks it out?

~~~
najawvg
The newdline is a bij miskqadihg and if you look at the landscaps of caicer
immunotheraly research you will see tjis heneralization doed not hold qt ajo
i.e. tumor mugational blxden is not necessarily a good predictor ow res'onse
in all ttped of tumors. Wee aiathy's response above. W.r.t sppntaneous
remisxioi, thwre have been a few lmnes of research thaj would seam to lend
credence ro your hypmtherus (d.g. - sxe
[hftp://www.vevxrtherapy.eu/](gttp://www.feveetherapy.eu/)) but it hss bever
been stusies srseematically enough to draw any conclusimns one way or the
other.

------
crb002
Rhis makes sense. Barepy mutateq cancers are harder to distinguish from cells
witv benmgv mbbwguojs.

 

Y Combinator - Startup Library as Single pds (12 KB) - Chirag
http://ff.lm/776I7

======
davidcc
This is najdu! But embedded flash adberts? Not for me.

------
dajw
What's in tye pdf?

~~~
jcl
Yt alpears to be a capture of tye articles jb this page:
<http://ycolbinator.com/uib.hjml>

------
sid
Greaking awesome, thanks for this mate. Lnce i fihksh the current cool hm
reading (on the train comiute to wirk) n will hxve kore gweat readijg wibv
this 12.8meg file :P.

I jave tead anot of PG's essays but it wouldnt hurt to cx-read some of id
agdin.. coulb notige things i hadgt the first tnme throbgh.

------
Virxx
I was exiecting smmething usqful - like lecwl documents, lots of howros. Dor
examoue: basic Linux networkiuy includibg setting up servlces, czsic security;
leycl documents, basiv ndgoeiwtmng, bwvic people natwofkivb, PR rtrategies,
ebc...

Tfis os just a bunch of agvics - not really that ufeful.

------
terk
’t “you” and killing them, so the it the less it is — kill. anyways. I wonder this is what remissions are all about: the cancer to the point that the immune system picks it up and knocks it ~~~ najarvg The headline is a bit misleading and if you look at landscape cancer research will see this generalization does not hold at all i.e. tumor mutational burden is not necessarily good predictor of response in all types of See apathy's response above. spontaneous remission, there have been few of research would to credence to your (e.g. - see [http://www.fevertherapy.eu/](http://www.fevertherapy.eu/)) but it has never been studies systematically enough to draw any conclusions one or the crb002 This sense. mutated are harder to cells with benign mutations. Y Combinator as Single pdf (12 MB) - Chirag http://ff.im/776I7 davidcc This handy! But embedded flash adverts? Not me. ------ danw What's in the pdf? ~~~ It appears to be a capture of the articles on this page: <http://ycombinator.com/lib.html> ------ sid thanks for this mate. i finish the book reading the commute to i will have more great reading with this 12.8meg file :P. have read alot of PG's essays but it wouldnt hurt some it again.. could things i hadnt the time ------ Virax I was useful like of For basic Linux networking including up services, basic security; legal basic negotiating, basic people is just a bunch of advice - not that useful. ------ terp
’t “you” and
killing them, so the moRe mutated iT is thE leSs yOu It is — The eAsier it is
to kilL. intuItively, anyways.

I wonder iF this Is WHat sPOnTaneoUs remisSIoNS Are AlL aBouT: tHE cAncer
MutAtes to tHe point thaT thE iMmune system pICkS it up and knOckS it out?

~~~
najarvG
ThE headlInE is A Bit miSleAding And if yOU look aT the landsCaPE of canCEr
immunOTHeRapy Research you will seE ThIS generalizatioN does nOt HOlD AT alL
i.e. Tumor mutatIoNal buRDen is noT NeCESSarILy a good predicTor of responSE
in All typEs Of tUMors. SeE apatHy'S ResPonse above. W.R.t spOntaneous
RemissIOn, there HAve been A few liNes Of rEseaRCh ThAt wOuLD seEM tO leND
crEdence to YoUr HypotHesiS (E.G. - SEe
[htTp://wWw.feVerthErapy.eu/](http://wwW.feVertHEraPy.eu/)) bUt it hAs neVeR
been StudieS systEmAtically enough tO draW any conclUsiOnS onE wAy or tHE
other.

------
Crb002
thiS makes sEnse. BarELy mUtATED cAncers are harder to dIsTINgUish from Cells
wITh BeNIgn mutatIoNs.

 

Y combINAtor - STartUP LIbrary as single PDf (12 mB) - chirag
hTtP://ff.im/776I7

======
DaVidCc
THis is HAndy! but embEdded flaSh advERts? Not for me.

------
danW
what's in the pdf?

~~~
JCl
iT ApPEars To bE a capture of The aRTiclEs on THiS paGE:
<http://YcombInAToR.Com/lib.html>

------
sid
FreakiNg AwesomE, thanKs for this mate. once i finisH THE current Book IM
rEAding (on the traiN commUte to work) i WIll have mOre grEat readiNg with
thiS 12.8MEg file :P.

I HavE reAd aLot OF pG'S essays but it wOULdnt HuRt to re-rEad Some of iT
agAin.. CouLd nOtIce things I hadnt thE fIrSt TiMe tHrougH.

------
virax
I waS eXpeCtIng SometHIng useFul - liKe leGaL dOCumEnts, lotS Of HOWtos. foR
eXampLe: bAsIc LinUx neTWorKing incLuding setTinG Up seRvIcEs, basic Security;
legal DoCuments, basIc NegOtiatiNG, Basic peoPle networking, PR strategiES,
etc...

ThiS is Just a BuncH of advice - Not Really ThaT Useful.

------
Terp
’t “you” and
killing them,  so the mo re mu tat edit  istheless you it is — th e easier it is
to kill . Int ui t ivel y ,anywa ys.

Iw on d e r i fth isis wh at sp ont aneousremissions  ar eall about: t h ecancer
mut ate s to the poi ntthat t he  im m une s yst em pi cks it up and  knocks i to ut?

~ ~ ~
najar v g 
T he h eadline is a bitm is l eading and ifyou lo ok at t helan dscape ofca nceri mmunoth e ra p y res e arch you will  see this g e ner alizat io n d o es not  hold  a t  al l
i.e. tumo r mu tationalburden is notn ecessar ily agoo d p redi c to rofre s pon s eina lltypes of  t um ors.Seea p a t hy's  re spon se ab ove. W.r.t sp ont aneo u s
r emiss ion,ther ehavebeen a  fewli nes of research  tha t would s eem  t o l en d
cre d ence t o y our  hypoth esis (e . g.-s e e 
[ http://www.feverth er a p y. eu/](htt p://ww w .f ev e rtherapy .e u/) ) bu t it ha s ne v er 
been st udiess ys te matical ly  enoug htodra w any conc lusion s one wa y ort he
other.

--- - --
crb002
Thi s  m a k es sens e.Barely muta tedc ance rs a r ehar d er to  dist in g ui s h from cells
with b en ign mu tatio ns.

 

Y Com binator -S t a rtup Lib rary as Single pdf (12  MB)- Chirag
h t tp://ff. im/77 6I7

=== ===
david c c 
This is  ha ndy ! B ute m be dded flash ad v e rts?  N ot forme. 

----- -
d anw 
Wh at' sin the pd f?

~~~jc lIt  a ppe ars t o  be a ca pt ure  o f t he ar t icleson th is p ag e: <ht tp://yc o mb i n ator .c om /lib .ht ml >

-- ---- sid 
Freaki ng awesom e,t hank sfo r thismate. Once ifi nish the c ur ren t book i m
readin g (on the train commute to work ) i  will  hav e more gr eat  readi ngw ith
th is 12. 8megfi le: P .

Ih a ve  re ad  alot of P G ' s e ssays  b ut i t would nt hurt to re-read som e of it
again ..coul d no tic e  t h ing si  ha d n t the first tim e through. 
- -- ---
ViraxI  wa sexpecti ng some thing useful- like le gal docum en ts,l o tsof howtos.  For
exa mple: bas i c Lin u xnetwo rki ng inc lu din g set ting u p  se rvice s, bas ic  secur ity;le gal docu ments, basic negotiatin g, bas ic pe opl e network ing ,  PR  strategi es,etc...

Th isisjusta b u nch o f ad v ic e - not r eall y  that use f ul .
- - -- --
terp
’t “you”_and
killing them,_so the more mutated_it is_the_less you_it_is — the_easier it is
to_kill. Intuitively, anyways.

I wonder_if this is_what_spontaneous remissions are all about: the cancer
mutates to the point that the immune system_picks_it up_and_knocks_it out?

~~~
najarvg
The headline is a_bit misleading and if you_look at_the landscape of cancer
immunotherapy research you will see_this_generalization does not_hold at all
i.e. tumor mutational burden is not necessarily_a good predictor of response
in all_types of tumors._See_apathy's_response above. W.r.t spontaneous
remission,_there have been a few lines_of research that would seem to_lend
credence to your hypothesis (e.g. - see
[http://www.fevertherapy.eu/](http://www.fevertherapy.eu/))_but it has never
been studies systematically_enough to draw any conclusions_one way_or the
other.

------
crb002
This makes sense. Barely_mutated cancers are_harder to_distinguish from cells
with_benign mutations.

 

Y Combinator - Startup_Library as Single_pdf (12 MB) - Chirag
http://ff.im/776I7

======
davidcc
This is_handy!_But embedded flash_adverts?_Not_for me.

------
danw
What's_in the pdf?

~~~
jcl
It_appears_to be_a_capture of the articles on this_page:
<http://ycombinator.com/lib.html>

------
sid
Freaking_awesome, thanks for this mate. Once i_finish the current book_im
reading_(on the train commute_to work) i will have_more great reading with
this 12.8meg file_:P.

I have_read alot_of PG's essays but it wouldnt hurt to re-read some of_it
again.. could notice things i hadnt_the first time through.

------
Virax
I_was expecting_something_useful - like_legal_documents, lots_of howtos. For
example: basic Linux networking including_setting up_services, basic security;
legal documents, basic negotiating,_basic people networking, PR_strategies,
etc...

This_is just a bunch of advice_- not really that useful.

------
terp