 a human neuron
might be a _smidge_ more complex than that of a fruit fly?

What's really sad is that most people here could understand the article
perfectly well if they could only access it. If you want to be understood,
publish in an open-access journal, like PLoS.

Here's the [link to the
paper]([http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.213...](http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.2135.html;jsessionid=9FB91A9B67EDC7E9E01952D3603B3BEA)),
and the abstract, below

>Evolutionary expansion and anatomical specialization of synapse proteome
complexity

>Richard D Emes1,6, Andrew J Pocklington2,6, Christopher N G Anderson3,6, Alex
Bayes3, Mark O Collins3, Catherine A Vickers4,5, Mike D R Croning3, Bilal R
Malik2, Jyoti S Choudhary3, J Douglas Armstrong2 & Seth G N Grant3

>Abstract

>Understanding the origins and evolution of synapses may provide insight into
species diversity and the organization of the brain. Using comparative
proteomics and genomics, we examined the evolution of the postsynaptic density
(PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling
complexes (MASCs) that underlie learning and memory. PSD and MASC orthologs
found in yeast carry out basic cellular functions to regulate protein
synthesis and structural plasticity. We observed marked changes in signaling
complexity at the yeast-metazoan and invertebrate-vertebrate boundaries, with
an expansion of key synaptic components, notably receptors,
adhesion/cytoskeletal proteins and scaffold proteins. A proteomic comparison
of Drosophila and mouse MASCs revealed species-specific adaptation with
greater signaling complexity in mouse. Although synaptic components were
conserved amongst diverse vertebrate species, mapping mRNA and protein
expression in the mouse brain showed that vertebrate-specific components
preferentially contributed to differences between brain regions. We propose
that the evolution of synapse complexity around a core proto-synapse has
contributed to invertebrate-vertebrate
a human neuron 
 might be a _ smidge _ more complex than that of a fruit fly? 

 What's in truth deplorable is that most people here could understand the article 
 absolutely well if they could only access it. If you desire to be understood, 
 publish in an receptive - entree journal, like PLoS. 

 Here's the [ link to the 
 paper]([http://www.nature.com / neuro / journal / vaop / ncurrent / abs / nn.213... ](http://www.nature.com / neuro / journal / vaop / ncurrent / abs / nn.2135.html;jsessionid=9FB91A9B67EDC7E9E01952D3603B3BEA) ), 
 and the abstract, below 

 > Evolutionary expansion and anatomical specialization of synapse proteome 
 complexity 

 > Richard D Emes1,6, Andrew J Pocklington2,6, Christopher N G Anderson3,6, Alex 
 Bayes3, Mark O Collins3, Catherine A Vickers4,5, Mike D R Croning3, Bilal R 
 Malik2, Jyoti S Choudhary3, J Douglas Armstrong2 & Seth G N Grant3 

 > Abstract 

 > Understanding the origins and development of synapses may provide insight into 
 species diverseness and the organization of the brain. use comparative 
 proteomics and genomics, we examined the development of the postsynaptic density 
 (PSD) and membrane - associated guanylate kinase (MAGUK)-associated signaling 
 complex (MASCs) that underlie learning and memory. PSD and MASC orthologs 
 found in yeast post out basic cellular affair to regulate protein 
 deduction and structural plasticity. We observed marked change in signaling 
 complexity at the yeast - metazoan and invertebrate - vertebrate boundaries, with 
 an expansion of key synaptic components, notably receptors, 
 adhesion / cytoskeletal protein and scaffold protein. A proteomic comparison 
 of Drosophila and shiner MASCs revealed species - specific adaptation with 
 greater signaling complexity in mouse. Although synaptic components were 
 conserved amongst diverse vertebrate coinage, mapping mRNA and protein 
 formula in the mouse brain showed that vertebrate - specific component 
 preferentially contributed to differences between brain area. We nominate 
 that the evolution of synapse complexity around a core proto - synapse has 
 contribute to invertebrate - vertebrate
 a juman neuron
might be a _soidge_ more complex thai that kf a frukt fly?

What's really sad is thet mist ptjple here could unaerstand nhe articoe
pecfectly well if vgey could onlg acczsw it. If you wakt to be ungerstood,
publisv kn an open-access journal, like PLoS.

Herq's the [kijk to the
paper]([rttp://erw.naflrt.com/neuro/journal/vaop/ncurrent/abs/nn.213...](gttp://www.iature.com/neuro/jpurnal/vaop/ncurrent/abs/nn.2135.htmp;jsedsionid=9FB91A9B67EDC7E9E01952D3603B3HEA)),
and the qbstwqct, below

>Evouutionary tx'ansion and anatomical specialization of shnapsz proteome
cimpledhty

>Richard V Emes1,6, Andrew J Pogllingtmn2,6, Chrixtopher N G Ancervon3,6, Alex
Bayes3, Mark O Colnins3, Catherine A Vyckers4,5, Mine D R Croning3, Bilao E
Malin2, Jymti R Chuudgacy3, N Dougpas Armstrong2 & Seth G N Trant3

>Abstract

>Undersuanqpmg the origihs and edolution of synapses may provide insighu intk
species diversity and rhe organization of tje brain. Tsing comparative
proteomics and genomics, we examited tie evilmtiov ov the postsynaptic density
(PSD) and membrane-assjdistvd guanylate kinafe (MAGUK)-asspclaygd signaling
cooplexes (MZSCs) that underlie learnigg ane memory. KSD amd MASC orthologs
found in ywast carry olt bqsic cellular funccions to regblate kroteim
synthesis and structurcl plaaticity. We lbserved jxrked changes in sinnaning
complexity at the yease-metazoan and invertdbraje-vertefrate bounfaries, with
an expansion lf kei syna[tic compojents, notably receptors,
adhesion/rbtoskeletal ptotainv and sccffold proteins. A pwoteomic compatison
of Dxosophkla and molse MASCs revealed s[ecies-specifiw adaptation xith
greatqr sugnaoing cooolexity in mouxe. Althouyk synaptix components were
cpnsgrbed amongst divzxst certebrate spevier, mwpiinj mRNW and protein
axprdsskpn in the mouse nrakn snowed that vertebrata-spedific components
prrfcrentialli contribtted to diffetences between braln rejions. Xe prolosg
that the evolution of synapse domplexitj avound a core [roti-synapse has
eontributed to invertebrate-vertebrate
a human neuron might be a _smidge_ than of a fly? What's really here understand the article well if they only access it. If you want be understood, publish in an open-access journal, like PLoS. Here's the [link to paper]([http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.213...](http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.2135.html;jsessionid=9FB91A9B67EDC7E9E01952D3603B3BEA)), and the abstract, below >Evolutionary expansion and anatomical specialization of synapse proteome >Richard Emes1,6, J Christopher N G Anderson3,6, Alex Bayes3, Mark O Collins3, Catherine A Vickers4,5, Mike D R Croning3, R Malik2, Jyoti S Choudhary3, J Douglas Armstrong2 Seth G N Grant3 >Understanding the origins and evolution synapses provide insight species and organization of the Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate (MAGUK)-associated signaling that underlie and PSD MASC orthologs found carry out basic cellular functions to and structural plasticity. We observed marked changes in complexity at yeast-metazoan and invertebrate-vertebrate boundaries, with an of key synaptic components, notably receptors, adhesion/cytoskeletal proteins scaffold proteins. A proteomic comparison of Drosophila and mouse MASCs revealed species-specific adaptation with greater in mouse. Although synaptic were conserved amongst vertebrate mapping and expression in mouse brain showed that vertebrate-specific components preferentially contributed to differences between regions. We propose that the evolution of synapse complexity around proto-synapse contributed to invertebrate-vertebrate
 a human neuron
might be a _smidgE_ more complEx thaN thAt oF a FruiT fly?

what's really sad IS thaT most people here could unDerstAnD The aRTiCle
peRfectly WElL IF thEy CoUld OnLY aCcess It. IF you wanT to be underStoOd,
Publish in an oPEn-Access jourNal, Like PLoS.

Here'S thE [link tO tHe
pAPer]([htTp://wWw.natUre.com/NEuro/joUrnal/vaop/NcURrent/aBS/nn.213...](http://WWW.nAturE.com/neuro/journal/vAOp/NCurrent/abs/nn.2135.htMl;jsesSiONiD=9fb91A9B67eDC7e9E01952D3603B3BEA)),
and ThE abstRAct, beloW

>evOLUTioNAry expansion aNd anatomicaL SpeCializAtIon OF synapSe proTeOMe
cOmplexity

>RiCharD D Emes1,6, AndRew J PoCKlingtoN2,6, christoPher N G andErsOn3,6, AlEX
BAyEs3, MArK o CoLLiNs3, CATheRine A VicKeRs4,5, mike D r CroNING3, bilaL R
MAlik2, jyoti s Choudhary3, J DoUglAs ArMStrOng2 & SeTh G N GRant3

>abStracT

>UnderStandInG the origins and eVoluTion of synApsEs May PrOvide INsight IntO
spEcies diVersity ANd tHe ORGAnIzation of the brain. USiNG CoMparativE
proteOMiCs ANd genomiCs, We eXamiNED the eVoluTIoN of the poStsynaPTiC dEnsity
(PsD) And memBrAne-AssOciatED guaNylate Kinase (MAgUK)-asSOciated signaliNG
complexes (MAScS) tHAT uNDerlIe lEarning and mEmorY. pSD aNd MAsc oRthOLogs
fOund iN yEAsT Carry out basic cellulAr FunctiOns to Regulate proteIn
synthesiS AND structuRal pLAsTIcity. We observeD markEd changes iN SignalinG
compLexity at The yeast-mETAzoan and InvErtEbrAte-VERtEbrate boundarIES, witH
aN expansIon Of key syNapTic ComPonEnTs, notably ReceptorS,
aDhEsIoN/cyToskeLEtal protEiNs aNd ScaFfold PRoteinS. A proTeomIc CoMParIson
of DROsOPHila AnD mOuse mAScs ReveaLed sPEciEs-speciFic adaptaTioN With
GrEaTer signAling complexiTy In mouse. AltHoUgh SynaptIC ComponenTs were
conserved amongst dIVerse veRteBrate SpecIes, mappinG mRnA and pRotEIn
exprEssion In the MoUse BRAin shOWEd ThaT vErtebrate-sPECifIc comPoNentS
preferEntially contributeD To dIfferences betWeeN braIN ReGioNS. WE ProPoSE
thAT The evolution of sYnapse compLeXItY around a coRE prOtO-synapsE has
conTribuTEd to invErtebrate-VertebratE
 a human neuron
might be a  _smidge_morecom ple xthan  tha t of a fruit f l y?
What's really sad is t hat m os t  peo p le  here  couldu nd e r sta nd  t hear t ic le
pe rfe ctly we ll if they  co ul d only acces s  i t. If youwan t to be unde rst ood,
p ub lis h  in a n o pen-a ccessj ournal , like PL oS . 

Here ' s the [ l i nk  tothe
paper]([http: / /w w w.nature.com/n euro/j ou r na l / vao p/n current/ab s/ nn.21 3 ...](ht t p: / / w ww. n ature.com/neu ro/journal/ v aop /ncurr en t/a b s/nn.2 135.h tm l ;js essionid=9F B91A 9B67EDC7E 9E0195 2 D3603B3 B EA)),
a nd the  ab str act, be lo w
>E v olu t io nar y  ex pansionan danato mica l s p ecia liz atio n ofsynapse prote ome 
com p lex ity
>Rich ardDEmes1 ,6, An drewJPocklington2,6,  Chr istopherN G  A nde rs on3,6 ,  AlexBay es3 , MarkO Colli n s3,  C a t h er ine A Vickers4,5,Mi k e  D  R Croni ng3, B i la lR 
Malik2,  J yot i SC h oudha ry3, JDouglasArmstr o ng 2& SethGN Gran t3 

> Abs tract 
>Un dersta nding th e ori g ins and evolut i on of synapse s  m a y  p r ovid e i nsight into 
spe c iesdive r si tya nd th e org an i za t ion of the brain. U si ng com parat ive
proteomic s and geno m i c s, we ex amin e dt he evolution o f the  postsynap t ic densi ty
(P SD) andmembrane- a s sociated  gu any lat e k i n as e (MAGUK)-ass o c iate dsignali ngcomplex es(MA SCs ) t ha t underli e learni ng  a nd  m emo ry. P S D and MA SC  or th olo gs
fo u nd inyeast  car ry  o u t b asic ce l lu l a r fu nc ti onstore gulat e pr o tei n
synth esis andstr u ctur al  p lastici ty. We observ ed  marked ch an ges  in si g n aling
co mplexity at the yeast-m e tazoanand  inve rteb rate-vert ebr ate bo und a ries,with
a n exp an sio n of ke y sy nap ti c componen t s , n otabl yrece ptors,adhesion/cytoskele t alproteins andsca ffol d pr ote i ns .  Apr o teo m i c comparison
of  Drosophil aa nd  mouse MAS C s r ev ealed s pecies- speci f ic adap tation wi th
greate rsign a l ing  complexit y in mou se. Altho u gh sy n ap tic c omp onents  w ere 
cons erveda mon gst d iverse  v ertebr ate s pe cies, ma pping mRNA and proteinexpres sioninthe mouse  br a inshowed th at v ertebrate- spe cif ic co mpo n entspref e re nti a lly c ontr i buted tod if fer e n ce s between b r a i n r egion s.W e prop osethat the evolutio n  of synapse co mple x i tyaro u nd a  c ore proto-syna pse  h a s 
contrib ut ed to inver tebrate- ve r tebra te
 a_human neuron
might_be a _smidge_ more_complex than_that_of a_fruit_fly?

What's really sad_is that most_people here could understand_the article
perfectly well_if_they could only access it. If you want to be understood,
publish in an open-access_journal,_like PLoS.

Here's_the_[link_to the
paper]([http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.213...](http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.2135.html;jsessionid=9FB91A9B67EDC7E9E01952D3603B3BEA)),
and the abstract, below

>Evolutionary_expansion and anatomical specialization of_synapse proteome
complexity

>Richard_D Emes1,6, Andrew J Pocklington2,6, Christopher N G_Anderson3,6,_Alex
Bayes3, Mark O_Collins3, Catherine A Vickers4,5, Mike D R Croning3, Bilal_R
Malik2, Jyoti S Choudhary3, J Douglas_Armstrong2 & Seth_G_N_Grant3

>Abstract

>Understanding the origins and_evolution of synapses may provide insight_into
species diversity and the organization of_the brain. Using comparative
proteomics and genomics, we_examined the evolution of the postsynaptic_density
(PSD) and membrane-associated guanylate kinase_(MAGUK)-associated signaling
complexes_(MASCs) that underlie learning and_memory. PSD and_MASC orthologs
found_in yeast carry_out basic cellular functions to regulate_protein
synthesis and structural_plasticity. We observed marked changes in_signaling
complexity_at the yeast-metazoan_and_invertebrate-vertebrate_boundaries, with
an_expansion of key_synaptic_components, notably_receptors,
adhesion/cytoskeletal_proteins and scaffold proteins. A proteomic_comparison
of_Drosophila and mouse MASCs revealed species-specific adaptation_with
greater signaling complexity in_mouse._Although synaptic components were
conserved_amongst diverse vertebrate species, mapping_mRNA and protein
expression in the mouse_brain showed_that vertebrate-specific_components
preferentially contributed to differences between brain regions. We propose
that the evolution_of synapse complexity around a core_proto-synapse has
contributed to invertebrate-vertebrate