 May 11,1946 an article in the Journal of the American Medical Association (JAMA) by Massachusetts General Hospital's Dr. Saul Hertz and Massachusetts Institute of Technology's Dr.Arthur Roberts, described the successful use of treating Graves' Disease with radioactive iodine (RAI) was published. Additionally, Sam Seidlin. brought further development in the field describing a successful treatment of a patient with thyroid cancer metastases using radioiodine (I-131). These articles are considered by many historians as the most important articles ever published in nuclear medicine. Although the earliest use of I-131 was devoted to therapy of thyroid cancer, its use was later expanded to include imaging of the thyroid gland, quantification of the thyroid function, and therapy for hyperthyroidism. Among the many radionuclides that were discovered for medical-use, none were as important as the discovery and development of Technetium-99m. It was first discovered in 1937 by C. Perrier and E. Segre as an artificial element to fill space number 43 in the Periodic Table. The development of a generator system to produce Technetium-99m in the 1960s became a practical method for medical use. Today, Technetium-99m is the most utilized element in nuclear medicine and is employed in a wide variety of nuclear medicine imaging studies.
 
Widespread clinical use of nuclear medicine began in the early 1950s, as knowledge expanded about radionuclides, detection of radioactivity, and using certain radionuclides to trace biochemical processes. Pioneering works by Benedict Cassen in developing the first rectilinear scanner and Hal O. Anger's scintillation camera (Anger camera) broadened the young discipline of nuclear medicine into a full-fledged medical imaging specialty.

By the early 1960s, in southern Scandinavia, Niels A. Lassen, David H. Ingvar, and Erik Skinhøj developed techniques that provided the first blood flow maps of the brain, which initially involved xenon-133 inhalation; an intra-arterial equivalent was developed soon after, enabling measurement of the local distribution of cerebral activity for patients with neuropsychiatric disorders such as schizophrenia. Later versions would have 254 scintillators so a two-dimensional image could be produced on a color monitor. It allowed them to construct images reflecting brain activation from speaking, reading, visual or auditory perception and voluntary movement. The technique was also used to investigate, e.g., imagined sequential movements, mental calculation and mental spatial navigation.
 

May 11,1946 an article in the Journal of the American Medical Association (JAMA) by Massachusetts General Hospital's Dr. Saul Hertz and Massachusetts Institute of Technology's Dr. Arthur Roberts, described the successful use of treating Graves' Disease with radioactive iodine (RAI) was publish. Additionally, Sam Seidlin. bring further development in the field describing a successful discussion of a patient with thyroid cancer metastases practice radioiodine (I-131). These articles are considered by many historian as the about important articles always published in nuclear medicine. Although the early habit of I-131 was devoted to therapy of thyroid cancer, its use was later expanded to include imagination of the thyroid gland, quantification of the thyroid function, and therapy for hyperthyroidism. Among the many radionuclides that were learn for medical - use, none were equally important as the discovery and exploitation of Technetium-99 m. It was first discover in 1937 by C. Perrier and E. Segre as an artificial element to fill space numeral 43 in the Periodic Table. The development of a generator system to produce Technetium-99 m in the 1960s became a practical method for medical use. Today, Technetium-99 m is the most utilized element in nuclear medicine and is employed in a wide variety of nuclear medicine imagination study. 
 
 Widespread clinical manipulation of nuclear music begin in the early 1950s, as knowledge extend about radionuclides, detection of radioactivity, and using certain radionuclides to hound biochemical processes. Pioneering works by Benedict Cassen in developing the first rectilinear scanner and Hal O. Anger's scintillation television camera (Anger camera) broadened the young discipline of nuclear medicine into a full - fledged medical imagination specialization. 

 By the early 1960s, in southern Scandinavia, Niels A. Lassen, David H. Ingvar, and Erik Skinhøj developed techniques that provide the first blood flow map of the brain, which initially involved xenon-133 inhalation; an intra - arterial equivalent was developed soon subsequently, enabling measurement of the local distribution of cerebral activity for patients with neuropsychiatric disorders such as schizophrenia. Later version would have 254 scintillators thus a two - dimensional image could be grow on a color admonisher. It allowed them to construct images reflecting brain energizing from speaking, reading, visual or auditory sensing and voluntary movement. The technique was also used to investigate, e.g., imagine sequential movements, genial calculation and mental spatial navigation.
 Maj 11,1946 an article in the Jouvnal of the Amernxan Mevical Aasociatiun (JAMA) by Massachusetts Genxral Hosputal's Dr. Saul Hertz ana Massachlsetts Inwtitnte of Technologb'a Dr.Artmbr Rogcrts, bewcribed the sugcessful usa of treating Crxvzs' Disease with radioactive iodine (RWI) was luhlished. Additijnalkr, Saj Seidlin. brought further developmsnt in uhe field describimg a successful treatment lf a patient with thyrlid cancer netafrases using fadioiodint (N-131). These artjcles are considered by many hirtoricns as the nowt lkportant arvicles ever publismvd in ngclear kedicine. Althomgh tie eqrliest use of I-131 was vevoted to therapy os thyroid ccncer, its use was latwr expatded to kbcljde ikafing ov tie thyroid fland, quantufication of the thurjpc function, ahd thewa[y for hyperthyroidism. Among the many rddiknuclides that were disxovered for medical-usg, none werq as important as the discovery and development ox Tecindtibn-99m. It qad first discovered in 1937 by C. Perrier and E. Segws ss an artificial element to fllk space number 43 in tks Leriodic Table. The develokment if a genewatot system to produce Technetuum-99m in the 1960f became a practicap method fox medival uxe. Today, Technetium-99m is the most utilixed elemehg in nuclear medkcike dnd is employed in a wide dariety oh nuckear meaicime imading studifs.
 
Widespread clinical ude of ngclear medlcine began in the early 1950s, as kipwledge expamdad dbout rabionuckides, detectijn of radioactnvity, anb usine certain gadionuclmdes to tracq biochemical krocesses. Pioieering wjrks by Venedicg Cassen in devrloping tkt first rextilinear scanner end Fzl O. Anger's sciuuiloation camera (Amgef cwmvra) bwmadened the foune dkxciplkne of nuclcar medocine into a full-flegged medical imaging slegialty.

By jhe early 1960s, in southerm Scandinavia, Nield A. Lessen, Vavid N. Iggvar, and Erik Skinhøj developes techniqkes that providqd tme fyrst blood flow maps of the brain, which initially involved xenon-133 inyalation; an intra-arjerlal equivaleit was developeg soon after, enablint measurement of uhe local distribution kf cerabral activity for patients with neuropsychiatric disorders such as schizophrebia. Lavew versions soulc havv 254 feintillwtord so a two-dimensipnal image could be produced on a color mjnitor. It allowed them to comsgruct images teflecting brain activatioh from sleaking, reading, visual or auditpry perception and volunbary movenent. Fhe tebgnmque was also used tp invevtigare, e.g., inagiked sequential mofelents, menhal raleulation and mental spatial navigqtion.
 

May 11,1946 an article in the Journal American Association (JAMA) Massachusetts General Hospital's Institute Technology's Dr.Arthur Roberts, the successful use treating Graves' Disease with radioactive iodine was published. Additionally, Sam Seidlin. brought further development in the field describing a treatment of a patient with thyroid cancer metastases using radioiodine (I-131). These articles considered many as most important articles ever published in nuclear medicine. Although the earliest use of I-131 was devoted therapy of thyroid cancer, its use was later to include imaging of thyroid gland, quantification of the function, therapy for Among many that were discovered medical-use, none were as important as the discovery and development of Technetium-99m. It was first discovered in by C. E. Segre an element fill space number the Periodic Table. The development of to produce Technetium-99m in the 1960s became a method for use. Today, Technetium-99m is the most element in nuclear medicine and is employed in wide variety of nuclear medicine imaging studies. Widespread clinical use of nuclear medicine began in 1950s, as knowledge expanded radionuclides, detection of and certain to biochemical processes. works by Benedict Cassen in developing the first rectilinear scanner and O. Anger's scintillation camera (Anger camera) broadened the young discipline medicine a full-fledged medical specialty. By the early in Scandinavia, Niels A. Lassen, Ingvar, Erik that the blood flow maps of brain, which initially involved xenon-133 an intra-arterial equivalent was of the local distribution of cerebral activity for with neuropsychiatric disorders such as schizophrenia. Later would have 254 scintillators so a two-dimensional image could be produced on color monitor. them to construct images reflecting brain activation from reading, visual or auditory and voluntary movement. The technique was also used to e.g., sequential movements, calculation and mental navigation.
 May 11,1946 an article in the Journal oF the AmericAn MedIcaL AsSoCiatIon (JaMA) by MassachusETts GEneral Hospital's Dr. Saul HErtz aNd mAssaCHuSetts instituTE oF tEchNoLoGy's dr.aRtHur RoBerTs, descrIbed the sucCesSfUl use of treatINg graves' DiseAse With radioactIve Iodine (rAi) waS PubliSheD. AddiTionalLY, Sam SeIdlin. brouGhT FurtheR DevelopMENt In thE field describing a SUcCEssful treatmenT of a paTiENt WITh tHyrOid cancer mEtAstasES using rADiOIODinE (i-131). These articleS are consideREd bY many hIsTorIAns as tHe mosT iMPorTant articleS eveR publisheD in nucLEar mediCIne. AlthOugh thE eaRliEst uSE oF I-131 Was DeVOteD To TheRApy Of thyroiD cAnCer, itS use WAS LAter ExpAndeD to inClude imaging oF thE thyROid Gland, QuantIficAtIon of The thyRoid fUnCtion, and therapy For hYperthyroIdiSm. amoNg The maNY radioNucLidEs that wEre discOVerEd FOR MeDical-use, none were as ImPORtAnt as the DiscovERy AnD DevelopmEnT of techNETium-99m. it waS FiRst discoVered iN 1937 By c. PErrier aNd e. Segre As An aRtiFiciaL ElemEnt to fIll space NumbeR 43 In the Periodic TABle. The developMEnT OF a GEnerAtoR system to prOducE techNetiUM-99m In tHE 1960s becAme a pRaCTiCAl method for medical uSe. today, TEchneTium-99m is the mosT utilized eLEMEnt in nucLear MEdICine and is emploYed in A wide varieTY of nucleAr medIcine imaGing studiES.
 
widespreAd cLinIcaL usE OF nUclear medicinE BEgan In The earlY 1950s, aS knowleDge ExpAndEd aBoUt radionuClides, deTeCtIoN oF raDioacTIvity, and UsIng CeRtaIn radIOnucliDes to TracE bIoCHemIcal proCEsSES. PioNeErIng wOrkS bY BeneDict cAssEn in devEloping thE fiRSt reCtIlInear scAnner and Hal O. ANgEr's scintilLaTioN camerA (aNger cameRa) broadened the young discIPline of NucLear mEdicIne into a fUll-FledgeD meDIcal imAging sPeciaLtY.

By THE earlY 1960S, In SouThErn ScandinAVIa, NIels A. laSsen, david H. INgvar, and Erik SkinhøJ DevEloped techniqUes That PROvIdeD ThE FirSt BLooD FLow maps of the braIn, which iniTiALlY involved xENon-133 InHalatioN; an intrA-arteRIal equiValent was Developed SoOn afTER, enAbling measUrement oF the local DIstriBUtIon of CerEbral aCtIviTy for PatienTS wiTh neuRopsycHiAtric dIsordErS such as sChizophrenia. Later versioNs woulD have 254 SciNtillatorS so A Two-DimensionAl imAge could be ProDucEd on a ColOR moniTor. IT AlLowED them To coNStruct imaGEs RefLECtIng brain actIVATioN from SpeAKing, reAdinG, visual or auditory PErception and voLuntARY moVemENt. ThE tEchnique was alsO usEd TO InvestigAtE, e.g., imagined SequentiAl MOvemeNts, menTal calCulatioN ANd MEntal sPatiAl nAvigation.
 

 May 11,1946 an article in  the Journ al of  th e A me rica n Me dical Associat i on ( JAMA) by Massachusetts  Gene ra l  Hos p it al'sDr. Sau l  H e r tzan dMas sa c hu setts  In stitute  of Techno log y' s Dr.ArthurR ob erts, desc rib ed the succe ssf ul use  o f t r eatin g G raves ' Dise a se wit h radioac ti v e iodi n e (RAI) w as  pub lished. Additiona l ly ,  Sam Seidlin.brough tf ur t h erdev elopment i nthe f i eld des c ri b i n g a successful tr eatment ofa  pa tientwi tht hyroid  canc er met astases usi ng r adioiodin e (I-1 3 1). The s e artic les ar e c ons ider e dby  ma ny his t or ian s  as  the mos tim porta nt a r t i c leseve r pu blish ed in nuclear  me dici n e.Altho ugh t he e ar liest  use o f I-1 31  was devoted to  the rapy of t hyr oi d c an cer,i ts use  wa s l ater ex pandedt o i nc l u d eimaging of the thy ro i d  g land, qu antifi c at io n  of theth yro id f u n ction , an d  t herapy f or hyp e rt hy roidism .Amongth e m any  radi o nucl ides t hat were  disc o vered for medi c al-use, nonew er e as impo rta nt as the d isco v eryandd ev elo p mentof Te ch n et i um-99m. It was firs tdiscov eredin 1937 by C.  Perrier a n d E. Segre  asa na rtificial elem ent t o fill spa c e number  43 i n the Pe riodic Ta b l e. The d eve lop men t o f agenerator sys t e m to  p roduceTec hnetium -99 m i n t he19 60s becam e a prac ti ca lme tho d for medicalus e.To day , Tec h netium -99mis t he  m o stutilize d  e l e ment  i nnucl ear  m edici ne a n d i s emplo yed in awid e  var ie ty  of nuc lear medicine  i maging stu di es. 
 
Wid e s pread cl inical use of nuclear m e dicinebeg an in  the  early 19 50s , as k now l edge e xpande d abo ut  ra d i onucl i d es , d et ection ofr a dio activ it y, a nd usin g certain radionuc l ide s to trace bi och emic a l  p roc e ss e s.Pi o nee r i ng works by Ben edict Cass en in  developin g  th efirst r ectilin ear s c anner a nd Hal O.  Anger'ssc inti l l ati on camera(Anger c amera) br o adene d  t he yo ung  disci pl ine  of n uclear med icine  intoafull-f ledge dmedicalimaging specialty.

Bythe ea rly 1 960 s, in sou the r n S candinavi a, N iels A. La sse n,David  H. Ingva r, a n dEri k  Skin højd evelopedt ec hni q u es  that provi d e d  th e fir stb lood f lowmaps of the brain ,  which initial ly i n v olv edx enon -1 33 inhalation;  an  i n t ra-arter ia l equivalen t was de ve l opedsoon a fter,enablin g me a sureme nt o f t he localdis tr i butionof  c e rebral  act iv ity fo r pati e ntsw i th neuropsychiat ric d i s order s  su ch as  s chizoph r enia . Later ve rsions woul d have  254  scin tillato rs  so atwo -d imensional image cou ld be  produc ed  ona c olor m onit o r . Itallo we d t hem to co n s tr u ct  i m age s re flect in g br ain activ a tion fro m s p eaking,  r ead i n g, vis u al o r auditory  pe rcept i o n and volu n tary mo v ement . Thetechni que was als oused to  in v e stigate,e.g., ima g ine dsequ ential m ov emen ts , m en tal calculation  and men tal spat i a l navi gat i on.

 May_11,1946 an_article in the Journal_of the_American_Medical Association_(JAMA)_by Massachusetts General_Hospital's Dr. Saul_Hertz and Massachusetts Institute_of Technology's Dr.Arthur_Roberts,_described the successful use of treating Graves' Disease with radioactive iodine (RAI) was published._Additionally,_Sam Seidlin._brought_further_development in the field describing_a successful treatment of a_patient with_thyroid cancer metastases using radioiodine (I-131). These articles_are_considered by many_historians as the most important articles ever published in_nuclear medicine. Although the earliest use_of I-131 was_devoted_to_therapy of thyroid cancer,_its use was later expanded to_include imaging of the thyroid gland,_quantification of the thyroid function, and therapy_for hyperthyroidism. Among the many radionuclides_that were discovered for medical-use,_none were_as important as the discovery_and development of_Technetium-99m. It_was first discovered_in 1937 by C. Perrier and_E. Segre as_an artificial element to fill space_number_43 in the_Periodic_Table._The development_of a generator_system_to produce_Technetium-99m_in the 1960s became a practical_method_for medical use. Today, Technetium-99m is the_most utilized element in_nuclear_medicine and is employed_in a wide variety of_nuclear medicine imaging studies.
 
Widespread clinical_use of_nuclear medicine_began in the early 1950s, as knowledge expanded about radionuclides, detection_of radioactivity, and using certain radionuclides_to trace biochemical processes._Pioneering works_by_Benedict Cassen in_developing_the first_rectilinear scanner and Hal O. Anger's scintillation_camera (Anger_camera) broadened the young discipline of_nuclear medicine into a_full-fledged_medical imaging specialty.

By the early 1960s,_in southern Scandinavia, Niels A. Lassen,_David H. Ingvar, and Erik_Skinhøj_developed_techniques that provided the first_blood flow maps of the brain,_which initially involved_xenon-133 inhalation; an intra-arterial equivalent was developed_soon_after, enabling measurement of the local_distribution_of cerebral activity for patients with_neuropsychiatric_disorders_such as schizophrenia. Later versions_would have 254 scintillators so a_two-dimensional image could be produced on a color monitor._It allowed them_to construct images reflecting brain_activation_from_speaking, reading, visual or auditory perception and voluntary movement. The_technique was_also used to_investigate, e.g., imagined sequential movements, mental calculation and mental spatial_navigation.
 
