 binds covalently to adjacent guanines in the major groove of DNA, which distorts DNA to allow access of DNA-binding proteins in the minor groove. This will destabilize the interaction between the TATA-binding protein (TBP) to the TATA box. The end result is to immobilize the TATA-binding protein (TBP) on DNA in order to down-regulate transcription initiation.

Genetic engineering

TATA box modification 
Evolutionary changes have pushed plants to adapt to the changing environmental conditions. In the history of Earth, the development of Earth's aerobic atmosphere resulted in an iron deficiency in plants. Compared to other members of the same species, Malus baccata var. xiaojinensis has a TATA box inserted in the promoter upstream of the iron-regulated transporter 1 (IRT1) promoter. As a result, the promoter activity levels are enhanced, increasing TFIID activity and subsequently transcription initiation, resulting in a more iron-efficient phenotype.

See also 
 Pribnow box
 Initiator element

References 

Category:Regulatory sequences
Category:1978 in biology Geraldine Jones (character)

Geraldine Jones was a fictional African American character, the most famous recurring persona of comedian Flip Wilson. Geraldine was played as a sassy liberated Southern woman who was coarsely flirty yet faithful to her (unseen) boyfriend "Killer". Poorly educated, she was nevertheless confident; she did not change her behavior to suit anyone. Several of Geraldine's sayings entered U.S. popular culture as catchphrases, especially "When you're hot, you're hot; when you're not, you're not," "The Devil made me do it," and "What you see is what you get!"

Wilson portrayed Geraldine many times in the early 1970s on his variety series The Flip Wilson Show, though not on every episode. He made comedy albums featuring Geraldine, notably The Devil Made Me Buy This Dress, and he appeared as Geraldine on other programs such as Saturday Night Live. He sang and danced as Geraldine at the Kennedy Center in 1983 for Bob Hope's 80th birthday celebration. Wilson tired of the Geraldine character late in his career; he responded to most requests by saying: "She's retired."

Origin
Since the mid-1960s, Wilson had been using high-pitched voices to characterize women in his comedy routines. He
binds covalently to adjacent guanines in the major groove of DNA, which distorts deoxyribonucleic acid to leave access of DNA - bind protein in the minor groove. This will destabilize the interaction between the TATA - binding protein (TBP) to the TATA box. The goal result is to immobilize the TATA - bind protein (TBP) on DNA in order to down - regulate transcription trigger. 

 Genetic engineering 

 TATA box modification 
 Evolutionary change have pushed plants to adapt to the changing environmental conditions. In the history of Earth, the development of Earth's aerobic standard atmosphere resulted in an iron deficiency in plants. compare to other members of the same species, Malus baccata var. xiaojinensis have a TATA box inserted in the promoter upstream of the iron - regulated transporter 1 (IRT1) showman. As a result, the promoter activity levels are enhanced, increasing TFIID natural process and subsequently transcription initiation, resulting in a more iron - efficient phenotype. 

 See also 
  Pribnow box 
  Initiator element 

 References 

 Category: Regulatory sequences 
 Category:1978 in biota Geraldine Jones (fictional character) 

 Geraldine Jones was a fictional African American quality, the about celebrated recurring persona of comedian Flip Wilson. Geraldine was played as a sassy liberated Southern woman who was coarsely flirty yet close to her (unseen) boyfriend " Killer ". Poorly educated, she was nevertheless confident; she did not change her behavior to suit anyone. Several of Geraldine's sayings entered U.S. popular acculturation as catchphrases, particularly " When you're hot, you're hot; when you're not, you're not, " " The Devil made me do it, " and " What you see is what you have! " 

 Wilson portrayed Geraldine many times in the early 1970s on his variety show series The Flip Wilson Show, though not on every episode. He made comedy album featuring Geraldine, notably The Devil make Me Buy This Dress, and he appeared as Geraldine on early programs such as Saturday Night Live. He sang and danced as Geraldine at the Kennedy Center in 1983 for Bob Hope's 80th birthday celebration. Wilson banal of the Geraldine character late in his career; he respond to most requests by saying: " She's retire. " 

 Origin 
 Since the mid-1960s, Wilson had been using high - pitched voices to characterize women in his comedy routines. He
 bijds covalently to adjacekt guanines in tkw majoc groovs of DNA, which distorts DNA to allow axcess of DNA-binding proteinr in the linor griove. Rhis will vsstabillve ths intzrection between jhe TATA-bindhng protein (TB[) go the TATA box. The end result is to ymmobilozf the TATA-bindyng kroeein (NBK) on DNA in order to down-regulate transcgiption initiatiom.

Genetic engineering

TATA blx mldification 
Evolutlonary chantes rqve pushed puants to adapt to the dhanging environmental conditiovs. In the histotv of Garth, the detelopmvnt of Earth's aerobic atmospnere resulted ln an irin deficiency in planvs. Compared to other members mf the same species, Mqlus taccdta xqr. biakjmnehsis hws e TATA box jnserted in the promoter upstrtam if the iron-refulateq eransporter 1 (IRT1) promoter. As a result, tve lromoter activity levelw are enhanced, increading TFIIQ activity and subsequently transcription initiathon, rxsjltnkn in q lore iron-efficient phenotype.

See also 
 Pribnow goc
 Pnitiator element

Veferences 

Categoru:Rfgijatory sequenzes
Catzfody:1978 in biology Gerapdine Jjnes (xharacter)

Derakdine Jones was a fictional African Amegicab character, the modt famous rzcurrimg petsona of comedian Flip Cilson. Geraldine aas playes as a sassy libefatvd Smuthern woman who was coarfely flirvy yec faithfjl tp her (tnseen) boyvriend "Killer". Poorly edufated, sve was nevfrtheless confident; she did not change her benaeiog to suit anyoke. Several of Gqraldine's sayiugs entexed U.S. popular cllture as catchphrasqs, especially "Ahen you're hmt, you're hot; wheb you're vot, you're not," "Yhe Devil made me di it," and "What you xee js what you get!"

Cnlwon portrayed Grraudige meny tykes in the edrly 1970s um his variety sevier Thr Flip Wilson Show, tvougg not on every epixoqe. He maee comedr albums featiring Geraldine, nouably Vhe Detil Mace Ie Buy This Dress, and he appeaded as Gegalqine on othew prigrams such cs Saturday Night Live. He sang and dancev as Geraldine at the Kwnnedy Center in 1983 fpv Bob Hope's 80vh birehday celabration. Wilson tiree of the Geraldint character late in his carees; he gesponded to most requests by saying: "She's retired."

Origin
Since the mid-1960s, Wilwon hav feen using gigh-litchvd roiees to sharecverize women in hps comedy routines. He
binds covalently to adjacent guanines in the of which distorts to allow access minor This will destabilize interaction between the protein (TBP) to the TATA box. end result is to immobilize the TATA-binding protein (TBP) on DNA in order down-regulate transcription initiation. Genetic engineering TATA box modification Evolutionary changes have pushed plants adapt the environmental In the history of Earth, the development of Earth's aerobic atmosphere resulted in an iron deficiency plants. Compared to other members of the same Malus baccata var. xiaojinensis a TATA box inserted in promoter of the transporter (IRT1) As a result, promoter activity levels are enhanced, increasing TFIID activity and subsequently transcription initiation, resulting in a more iron-efficient See also Initiator element Category:Regulatory Category:1978 biology Geraldine Jones Jones was a fictional African American famous recurring persona of comedian Flip Wilson. Geraldine played as sassy liberated Southern woman who was flirty yet faithful to her (unseen) boyfriend "Killer". educated, she was nevertheless confident; she did not change her behavior to suit anyone. Several sayings entered U.S. popular as catchphrases, especially you're you're when not, you're "The Devil made me do it," and "What you see is you get!" Wilson portrayed Geraldine many times in the early his series The Flip Show, though not on episode. made comedy albums featuring The Made Dress, he as Geraldine on other such as Saturday Night Live. sang and danced as in 1983 for Bob Hope's 80th birthday celebration. tired of the Geraldine character late in career; he responded to most requests by saying: "She's retired." Origin Since mid-1960s, Wilson using high-pitched voices to characterize women in his routines. He
 binds covalently to adjacent Guanines in The maJor GroOvE of DnA, whIch distorts DNA TO allOw access of DNA-binding prOteinS iN The mINoR grooVe. This wILl DEStaBiLiZe tHe INtEractIon Between The TATA-binDinG pRotein (TBP) to tHE TaTA box. The eNd rEsult is to immObiLize thE TaTA-BIndinG prOtein (tBP) on Dna in ordEr to down-rEgULate trANscriptION iNitiAtion.

Genetic enginEErINg

TATA box modifIcatioN 
EVOlUTIonAry Changes havE pUshed PLants to ADaPT TO thE Changing envirOnmental conDItiOns. In tHe HisTOry of EArth, tHe DEveLopment of EaRth's Aerobic atMospheRE resultED in an irOn defiCieNcy In plANtS. COmpArED to OThEr mEMbeRs of the sAmE sPecieS, MalUS BACcatA vaR. xiaOjineNsis has a TATA bOx iNserTEd iN the pRomotEr upStReam oF the irOn-regUlAted transporter 1 (iRT1) pRomoter. As A reSuLt, tHe PromoTEr actiVitY leVels are EnhanceD, IncReASINg tFIID activity and suBsEQUeNtly tranScriptIOn InITiation, rEsUltIng iN A More iRon-eFFiCient pheNotype.

sEe AlSo 
 PribnOw Box
 IniTiAtoR elEment

rEferEnces 

CAtegory:REgulaTOry sequences
CaTEgory:1978 in biologY geRALdINe JoNes (Character)

GeRaldINe JoNes wAS a FicTIonal africAn aMeRIcan character, the mosT fAmous rEcurrIng persona of cOmedian FliP wILson. GeraLdinE WaS Played as a sassy LiberAted SoutheRN woman whO was cOarsely fLirty yet fAIThful to hEr (uNseEn) bOyfRIEnD "Killer". Poorly EDUcatEd, She was nEveRthelesS coNfiDenT; shE dId not chanGe her behAvIoR tO sUit AnyonE. several oF GEraLdIne'S sayiNGs enteRed U.S. PopuLaR cULtuRe as catCHpHRAses, EsPeCialLy "WHeN you'rE hot, YOu'rE hot; wheN you're not, You'RE not," "thE DEvil madE me do it," and "WhaT yOu see is whaT yOu gEt!"

WilsON PortrayeD Geraldine many times in thE Early 1970s oN hiS variEty sEries The FLip wilson shoW, Though Not on eVery ePiSodE. hE made COMeDy aLbUms featuriNG gerAldinE, nOtabLy The DeVil Made Me Buy This DrESs, aNd he appeared aS GeRaldINE oN otHEr PRogRaMS suCH As Saturday Night live. He sang AnD DaNced as GeraLDinE aT the KenNedy CenTer in 1983 FOr Bob HoPe's 80th birtHday celebRaTion. wILsoN tired of thE GeraldiNe charactER late IN hIs carEer; He respOnDed To mosT requeSTs bY sayiNg: "She's ReTired."

ORigin
siNce the miD-1960s, Wilson had been using higH-pitchEd voiCes To charactEriZE woMen in his cOmedY routines. HE
 binds covalently to adjac ent guanin es in  th e m aj or g roov e of DNA, whic h  dis torts DNA to allow acc ess o fD NA-b i nd ing p roteins in t hemi no r g ro o ve . Thi s w ill des tabilize t hein teraction be t we en the TAT A-b inding prote in(TBP)to  th e  TATA  bo x. Th e endr esultis to imm ob i lize t h e TATA- b i nd ingprotein (TBP) onD NA in order to do wn-reg ul a te t ran scr iption ini ti ation . 

Genet i ce n g ine e ring

TATA bo x modificat i on
Evolu ti ona r y chan ges h av e  pu shed plants  toadapt tothe ch a nging e n vironme ntal c ond iti ons. In  t hehi s tor y  o f E a rth , the de ve lo pment  ofE a r t h'saer obic  atmo sphere result edin a n  ir on de ficie ncyin  plan ts. Co mpare dto other member s of  the same  sp ec ies ,Malus baccat a v ar.  xiaoji nensish asaT A T Abox inserted in th ep r om oter ups treamo fth e  iron-re gu lat ed t r a nspor ter1  ( IRT1) pr omoter .  A sa resul t,  the p ro mot eractiv i ty l evelsare enha nced, increasing TFI I D activity an d  s u b se q uent lytranscripti on i n itia tion ,  r esu l tingin amo r ei ron-efficient pheno ty pe.

S ee al so 
 Pribnowbox
 Initi a t o r elemen t

R e fe r ences 

Catego ry:Re gulatory s e quencesCateg ory:1978  in biolo g y  Geraldi neJon es(ch a r ac ter)

Geraldi n e  Jon es  was afic tionalAfr ica n A mer ic an charac ter, the  m os tfa mou s rec u rring pe rs ona  o f c omedi a n Flip  Wils on.Ge ra l din e was p l ay e d  asasa ssylib er atedSout h ern  womanwho was c oar s elyfl ir ty yetfaithful to h er  (unseen)bo yfr iend " K i ller". P oorly educated, she was neverth ele ss co nfid ent; shedid  not c han g e herbehavi or to  s uit a nyone . Se ver al  of Gerald i n e's  sayi ng s en tered U .S. popular cultur e  as  catchphrases , e spec i a ll y " W he n  yo u' r e h o t , you're hot; w hen you're  n o t,  you're no t ,""T he Devi l mademe do it," an d "What y ou see is  w haty o u g et!"

Wils on portr ayed Gera l dinem an y tim esin the  e arl y 197 0s onh isvarie ty ser ie s TheFlipWi lson Sho w, though not on everyepisod e. He  ma de comedy  al b ums  featurin g Ge raldine, n ota bly  TheDev i l Mad e Me Bu y T h is Dr ess, and he ap p ea red a sGeraldine o n o the r pro gra m s such  asSaturday Night Li v e. He sang and  dan c e d a s G e rald in e at the Kenne dyCe n t er in 19 83  for Bob Ho pe's 80t hb irthd ay cel ebrati on. Wil s o nt ired o f th e G eraldinecha ra c ter lat ein his ca reer ;he res ponded to m o s t requests by sa ying: " She's ret ired. "
Origin Sinc e the mid- 1960s, Wils on had  bee n usi ng high -p itched  vo ic es to char a cterize w omenin hisco medy  ro utines . He 
 binds_covalently to_adjacent guanines in the_major groove_of_DNA, which_distorts_DNA to allow_access of DNA-binding_proteins in the minor_groove. This will_destabilize_the interaction between the TATA-binding protein (TBP) to the TATA box. The end result_is_to immobilize_the_TATA-binding_protein (TBP) on DNA in_order to down-regulate transcription initiation.

Genetic_engineering

TATA box_modification 
Evolutionary changes have pushed plants to adapt_to_the changing environmental_conditions. In the history of Earth, the development of_Earth's aerobic atmosphere resulted in an_iron deficiency in_plants._Compared_to other members of_the same species, Malus baccata var._xiaojinensis has a TATA box inserted_in the promoter upstream of the iron-regulated_transporter 1 (IRT1) promoter. As a_result, the promoter activity levels_are enhanced,_increasing TFIID activity and subsequently_transcription initiation, resulting_in a_more iron-efficient phenotype.

See_also 
 Pribnow box
 Initiator element

References_

Category:Regulatory sequences
Category:1978 in_biology Geraldine Jones (character)

Geraldine Jones was_a_fictional African American_character,_the_most famous_recurring persona of_comedian_Flip Wilson._Geraldine_was played as a sassy liberated_Southern_woman who was coarsely flirty yet faithful_to her (unseen) boyfriend_"Killer"._Poorly educated, she was_nevertheless confident; she did not_change her behavior to suit anyone._Several of_Geraldine's sayings_entered U.S. popular culture as catchphrases, especially "When you're hot, you're_hot; when you're not, you're not,"_"The Devil made me_do it,"_and_"What you see_is_what you_get!"

Wilson portrayed Geraldine many times in the_early 1970s_on his variety series The Flip_Wilson Show, though not_on_every episode. He made comedy albums_featuring Geraldine, notably The Devil Made_Me Buy This Dress, and_he_appeared_as Geraldine on other programs_such as Saturday Night Live. He_sang and danced_as Geraldine at the Kennedy Center in_1983_for Bob Hope's 80th birthday celebration._Wilson_tired of the Geraldine character late_in_his_career; he responded to most_requests by saying: "She's retired."

Origin
Since the_mid-1960s, Wilson had been using high-pitched voices to characterize_women in his_comedy routines. He