OR4; N(Rxe2x80x2)C(O)C(O)R4; N(Rxe2x80x2)S(O2)R4; N(Rxe2x80x2)R4; N(R4)2; OR4; OC(O)R4; OP(O)3H2; or CN.
Each Rxe2x80x2 is independently selected from hydrogen; (C1-C3)-aliphatic; phenyl or phenyl substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; or a 5-8 membered heterocyclic ring system optionally substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl.
Each R3 is independently selected from a 5-8 membered aromatic or non-aromatic carbocyclic or heterocyclic ring system each optionally substituted with halo, Rxe2x80x2, R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, xe2x80x94J or xe2x80x94K; or an 8-10 membered saturated, partially unsaturated, or aromatic bicyclic ring system containing 0-4 heteroatoms, said ring system optionally substituted with halo, Rxe2x80x2, R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, xe2x80x94J or xe2x80x94K.
Each R4 is independently selected from xe2x80x94N(Rxe2x80x2)2; xe2x80x94NRxe2x80x2C(O)xe2x80x94(C1-C4)-aliphatic optionally substituted with halo, Rxe2x80x2, N(Rxe2x80x2)2, ORxe2x80x2, CO2Rxe2x80x2, CON(Rxe2x80x2)2, SO2N(Rxe2x80x
OR4; N(Rxe2x80x2)C(O)C(O)R4; N(Rxe2x80x2)S(O2)R4; N(Rxe2x80x2)R4; N(R4)2; OR4; OC(O)R4; OP(O)3H2; or CN. 
 Each Rxe2x80x2 is independently selected from hydrogen; (C1 - C3)-aliphatic; phenyl or phenyl substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; or a 5 - 8 membered heterocyclic gang arrangement optionally substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl. 
 Each R3 is independently selected from a 5 - 8 membered aromatic or non - aromatic carbocyclic or heterocyclic closed chain system each optionally substituted with halo, Rxe2x80x2, R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, xe2x80x94J or xe2x80x94 K; or an 8 - 10 membered impregnate, partially unsaturated, or aromatic bicyclic band system incorporate 0 - 4 heteroatoms, said ring organization optionally substituted with halo, Rxe2x80x2, R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, xe2x80x94J or xe2x80x94K. 
 Each R4 is independently selected from xe2x80x94N(Rxe2x80x2)2; xe2x80x94NRxe2x80x2C(O)xe2x80x94(C1 - C4)-aliphatic optionally substitute with halo, Rxe2x80x2, N(Rxe2x80x2)2, ORxe2x80x2, CO2Rxe2x80x2, CON(Rxe2x80x2)2, SO2N(Rxe2x80x
OR4; J(Rxe2x80x2)C(O)C(O)R4; N(Rxe2x80x2)S(O2)R4; N(Rwe2x80x2)R4; N(R4)2; OR4; OC(O)R4; OP(O)3H2; oc CN.
Eacg Rxe2x80x2 ks independently selected frlm hydrigen; (C1-C3)-aliphatic; phenyu or phenjl substirutev with 1 to 3 subsvjtuents indepskdentnb selected from halo, methmxy, cyano, nitrm, xmnno, hydroxy, methyl or ethyl; or a 5-8 meibered neherocyclic rind syxeem kitlonally substituted with 1 to 3 sugstitueits independentky selected from halo, methlxy, fyano, nitro, amino, jydroxy, metyyl je ethyl.
Each F3 is indeptnbently seledted from a 5-8 membered aromatic ur nou-aromatic cqrvocjwlic or hetxrocycjic ring sysbvm each optionslly substitutcd wivh hqlo, Rxe2x80x2, R4, xe2x80x94C(O)Rxe2e80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, ve2x80x94J or fe2r80x94K; or an 8-10 membered sqtyrateg, pastiauoy jnsztnrafed, or arkmatic bicgclic ring wystem containing 0-4 neevtoatoms, said ring fyftem optionally substituted with halo, Rqe2x80x2, R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, ze2x80x94C(O)OR4, xe2x80x94J or xe2x80d94K.
Each R4 ys independently selected from xe2x80x94N(Rxe2x80x2)2; xe2x80x94NRxa2x80x2C(O)ee2b80x94(C1-E4)-qliphxrif optionally substituted with halo, Rxe2x80x2, N(Rxe2v80s2)2, PRqe2x80x2, CO2Rxe2x80x2, CON(Rwe2x80x2)2, SO2N(Rxe2x80x
OR4; N(Rxe2x80x2)C(O)C(O)R4; N(Rxe2x80x2)S(O2)R4; N(Rxe2x80x2)R4; N(R4)2; OR4; OC(O)R4; CN. Rxe2x80x2 is selected from hydrogen; with to 3 substituents selected from halo, cyano, nitro, amino, hydroxy, methyl or or a 5-8 membered heterocyclic ring system optionally substituted with 1 to 3 independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl. Each is selected a membered aromatic or non-aromatic carbocyclic or heterocyclic ring system each optionally substituted with halo, Rxe2x80x2, R4, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, xe2x80x94J or xe2x80x94K; or an 8-10 saturated, partially unsaturated, or bicyclic ring system containing 0-4 said system optionally with Rxe2x80x2, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4, or xe2x80x94K. Each R4 is independently selected from xe2x80x94N(Rxe2x80x2)2; xe2x80x94NRxe2x80x2C(O)xe2x80x94(C1-C4)-aliphatic optionally substituted with halo, Rxe2x80x2, N(Rxe2x80x2)2, ORxe2x80x2, CON(Rxe2x80x2)2, SO2N(Rxe2x80x
OR4; N(Rxe2x80x2)C(O)C(O)R4; N(Rxe2x80x2)S(O2)R4; N(RxE2x80x2)R4; N(R4)2; OR4; OC(o)R4; OP(O)3h2; or cN.
EAcH Rxe2X80x2 is Independently sELectEd from hydrogen; (C1-C3)-aliphaTic; phEnYL or pHEnYl subStituteD WiTH 1 To 3 sUbStItuEnTS iNdepeNdeNtly selEcted from hAlo, MeThoxy, cyano, niTRo, Amino, hydroXy, mEthyl or ethyl; Or a 5-8 MemberEd HetERocycLic Ring sYstem oPTionalLy substitUtED with 1 tO 3 SubstitUENtS indEpendently selecteD FrOM halo, methoxy, cyAno, nitRo, AMiNO, HydRoxY, methyl or eThYl.
EacH r3 is indePEnDENTly SElected from a 5-8 mEmbered aromATic Or non-aRoMatIC carboCycliC oR HetErocyclic riNg syStem each oPtionaLLy substITuted wiTh halo, rxe2X80x2, R4, Xe2x80x94c(o)RXe2X80x2, xE2x80X94c(O)R4, XE2x80X94C(O)or4, xe2X80x94J or xe2x80X94K; Or An 8-10 memBereD SATUratEd, pArtiAlly uNsaturated, or aRomAtic BIcyClic rIng syStem CoNtainIng 0-4 hetEroatOmS, said ring system OptiOnally subStiTuTed WiTh halO, rxe2x80x2, R4, Xe2x80X94C(O)rxe2x80x2, xe2X80x94C(O)R4, xe2X80X94C(O)oR4, XE2X80X94J Or xe2x80x94K.
Each R4 is indePeNDEnTly selecTed froM Xe2X80x94n(rxe2x80x2)2; xe2x80X94Nrxe2X80x2C(O)XE2X80x94(C1-C4)-aLiphATiC optionaLly subSTiTuTed with HaLo, Rxe2x80X2, N(rxe2X80x2)2, Orxe2x80x2, co2Rxe2X80x2, CON(RXe2x80x2)2, SO2N(RXe2x80x
OR4; N(Rxe2x80x2)C(O)C(O)R 4; N(Rxe2x 80x2) S(O 2)R 4;  N(R xe2x 80x2)R4; N(R4) 2 ; OR 4; OC(O)R4; OP(O)3H2;or CN .E achR xe 2x80x 2 is in d ep e n den tl ysel ec t ed  from  hy drogen;  (C1-C3)-a lip ha tic; phenylo rphenyl sub sti tuted with 1  to  3 sub st itu e nts i nde pende ntly s e lected  from hal o, methox y , cyano , ni tro,  amino, hydroxy,m et h yl or ethyl; o r a 5- 8m em b e red  he terocyclic  r ing s y stem op t io n a l lys ubstituted wi th 1 to 3 s u bst ituent sind e penden tly s el e cte d from halo , me thoxy, cy ano, n i tro, am i no, hyd roxy,met hyl  ore th yl .
E ac h  R3 is  in d epe ndentlyse le ctedfrom a 5 -8 m emb ered  arom atic or non-a rom atic car bocyc lic o r he te rocyc lic ri ng sy st em each optiona llysubstitut edwi thha lo, R x e2x80x 2,R4,  xe2x80 x94C(O) R xe2 x8 0 x 2 ,xe2x80x94C(O)R4, x e2 x 8 0x 94C(O)OR 4, xe2 x 80 x9 4 J or xe2 x8 0x9 4K;o r  an 8 -10m em bered sa turate d ,pa rtially  u nsatur at ed,  or  arom a ticbicycl ic ringsyste m  containing 0- 4  heteroatoms, sa i d  r i ng s yst em optional ly s u bsti tute d  w ith halo,  Rxe2 x8 0 x2 ,  R4, xe2x80x94C(O)R xe 2x80x2 , xe2 x80x94C(O)R4,  xe2x80x94 C ( O )OR4, xe 2x80 x 94 J  or xe2x80x94K .
Eac h R4 is in d ependent ly se lected f rom xe2x8 0 x 94N(Rxe2 x80 x2) 2;xe2 x 8 0x 94NRxe2x80x2C ( O )xe2 x8 0x94(C1 -C4 )-aliph ati c o pti ona ll y substit uted wit hha lo ,Rxe 2x80x 2 , N(Rxe2 x8 0x2 )2 , O Rxe2x 8 0x2, C O2Rxe 2x80 x2 ,C ON( Rxe2x80 x 2) 2 ,  SO2 N( Rx e2x8 0x
OR4; N(Rxe2x80x2)C(O)C(O)R4;_N(Rxe2x80x2)S(O2)R4; N(Rxe2x80x2)R4;_N(R4)2; OR4; OC(O)R4; OP(O)3H2;_or CN.
Each_Rxe2x80x2_is independently_selected_from hydrogen; (C1-C3)-aliphatic;_phenyl or phenyl_substituted with 1 to_3 substituents independently_selected_from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; or a 5-8 membered_heterocyclic_ring system_optionally_substituted_with 1 to 3 substituents_independently selected from halo, methoxy,_cyano, nitro,_amino, hydroxy, methyl or ethyl.
Each R3 is independently_selected_from a 5-8_membered aromatic or non-aromatic carbocyclic or heterocyclic ring system_each optionally substituted with halo, Rxe2x80x2,_R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4,_xe2x80x94C(O)OR4,_xe2x80x94J_or xe2x80x94K; or an_8-10 membered saturated, partially unsaturated, or_aromatic bicyclic ring system containing 0-4_heteroatoms, said ring system optionally substituted with_halo, Rxe2x80x2, R4, xe2x80x94C(O)Rxe2x80x2, xe2x80x94C(O)R4, xe2x80x94C(O)OR4,_xe2x80x94J or xe2x80x94K.
Each R4 is_independently selected_from xe2x80x94N(Rxe2x80x2)2; xe2x80x94NRxe2x80x2C(O)xe2x80x94(C1-C4)-aliphatic optionally substituted_with halo, Rxe2x80x2,_N(Rxe2x80x2)2, ORxe2x80x2,_CO2Rxe2x80x2, CON(Rxe2x80x2)2, SO2N(Rxe2x80x