 chamber by the filter and discharges it to the outside. Therefore, such isolator device can be also used basically both as the aseptic isolator and the containment isolator.
Moreover, when the isolator device is to be used, safety can be further improved by adjusting an air pressure in the chamber in accordance with the purpose. That is, when the isolator device is used as an aseptic isolator, the pressure in the chamber is set to a pressure higher than an outside air pressure (hereinafter referred to as a positive pressure), and even in the case of leakage from the chamber, since the air flows from the chamber side to the outside, airborne bacteria and the like are prevented from intruding into the chamber from the outside
On the other hand, if the isolator device is to be used as the containment isolator, the pressure in the chamber is set to a pressure lower than the outside air pressure (hereinafter referred to as a negative pressure) in use, and even in the case of the leakage from the chamber, since the air flows from the outside into the chamber, the chemical substances and the like in the chamber are prevented from contaminating the outside environment.
However, in the isolator device, a glass window through which the inside of the chamber can be visually checked from outside, a glove with which the worker performs the work, and an opening/closing door by which equipment is carried into the chamber or maintenance works are performed are provided. Therefore, it is difficult to completely shield the chamber of the isolator device in an airtight manner, and the shielding performance might be destroyed during operation of the isolator device. Moreover, even if the air pressure in the chamber is adjusted, there is limitation in providing a pressure difference all the time due to various factors such as fluctuation of the outside air pressure.
If any leakage is caused in the isolator device as above, in the aseptic isolator, the aseptic/dustless state in the chamber cannot be maintained, while in the case of the containment isolator, the chemical substances, microorganisms and the like handled in the chamber might leak to the outside environment.
As a method for avoiding such a risk during operation of the isolator device, Patent Literature 1 discussed below proposes a cleanliness maintaining device of an isolator device in which a negative pressure air suction passage whose pressure becomes negative both to the inside of the chamber and the outside is installed on an inner peripheral edge of a joint portion provided in the chamber, and the air passing
chamber by the filter and discharges it to the outside. Therefore, such isolator device can be also use basically both as the aseptic isolator and the containment isolator. 
 furthermore, when the isolator device is to be used, safety can be far better by adjusting an air press in the chamber in accordance with the function. That is, when the isolator device is used as an aseptic isolator, the pressure in the bedroom is set to a pressure higher than an outside tune pressure (hereinafter referred to as a positive pressure), and even in the case of escape from the chamber, since the air flows from the bedroom side to the outside, airborne bacteria and the like are prevented from intruding into the chamber from the outside 
 On the early hand, if the isolator device is to be use as the containment isolator, the pressure in the chamber is set to a atmospheric pressure lower than the outside air pressure (hereinafter referred to as a negative pressure) in use, and even in the case of the leakage from the chamber, since the air flows from the outside into the chamber, the chemical substances and the like in the chamber are prevent from contaminating the outside environment. 
 However, in the isolator device, a looking glass window through which the inside of the chamber can be visually checked from outside, a glove with which the proletarian performs the work, and an opening / closing doorway by which equipment is carried into the chamber or maintenance works are performed are provided. Therefore, it is difficult to completely shield the chamber of the isolator device in an airtight manner, and the shielding performance might be demolish during operation of the isolator device. furthermore, even if the tune pressure in the chamber is adjusted, there is restriction in providing a pressure difference all the meter due to various factors such as fluctuation of the outside air travel pressure. 
 If any escape is caused in the isolator device as above, in the aseptic isolator, the aseptic / dustless state in the chamber cannot be maintained, while in the case of the containment isolator, the chemical substance, microorganisms and the alike handled in the bedroom might leak to the outside environment. 
 As a method for avoiding such a hazard during operation of the isolator device, Patent Literature 1 discussed below proposes a cleanliness maintaining device of an isolator device in which a negative pressure air suction passage whose pressure becomes damaging both to the inside of the chamber and the outside is installed on an inside peripheral edge of a joint portion provided in the chamber, and the air passing
 chwmber by the filter and aischarges it to the ontside. Fhereford, such isolator device can bx alwo ustb basically both as ghe aseptpc isolatir aid the containmeif isolabjr.
Modcover, xhen the isolatpr device hs to be used, vawecy can be further improved by adjustyng an sig pressure in jhe cnwmbed in accordance with the purpose. Tgat is, xhen the isolatpr device is used as an asfptif isolator, the predsure in thg chwnber is set go a presslxe higher tgan an outside air pressure (herdinafcer referree ro wv a positivx presfure), and evek in tha case pf leakage frok tie cyamber, since the air hlows from the chambgr side to tke outside, airborne bqcreria and the oikd ade pdeventfd hrom intrudjng into thw chamber from the puewide
On the otger hagd, if the isolator device is to be used av tge containment isolator, the pressure in the fhamber if set to a pressure lower than the outside air prassurx (fertikwwreg referred to as a negative pressure) in use, ags tvek in the case of the leakagr vrpi the chamber, since ths air flows from tje outsyde ibto the crambrr, the chemical substances qnd the like un the chamber are prevented yrom cpntamonating the outside envnronmeht.
However, ij the isomxtor device, a glxss whndow through which the infide of tie chcmber cav be visuajly checkef from outside, a glove wlth wkich dhe worker performs the work, and an openiij/closing door bf wvich equnpment is carried igto the chambet or maincenancd works arv performxd are proviqed. Therefore, lt is difficnlt to coiplerely shield ghe chamber of the isolcuor device in an airtight makner, xhd the shieldiny keeformance mighy bd dqsnrobed dtsing operatimn ow tfr isouator dtricc. Mureofer, even if the air [resaure in the chambet ls adjustgd, there ys limitation in providing a prtssure dihferenve wll the time due to various fadtors sucj af fluctuatiog of the outside air pressure.
If any leakage is caused ii the isolator device aw above, in the asepjic isolator, tie ase[tic/dustlass state in the chanber cannot be malntained, while in the dase ox the containment isolator, the chemical substances, microorganisms and the like handlxd in the chajber mighn lzak to thq ouvsmde environment.
As a method for avoiding such a rmsk during o'eration of the isolator devive, Patent Literxture 1 discussed below pdoposes s cleanliness maintaining devicr of an isolator device ln which q negztive itesrure air suction psssage whosw pressyre necomes negatixe nobh to the lnsive kf the chamber and the outside iw instqlped on an inner 'eripheral efne of z joinj portion provides in hhe cfamber, and thr air passing
chamber by the filter and discharges it outside. such isolator can be also aseptic and the containment Moreover, when the device is to be used, safety be further improved by adjusting an air pressure in the chamber in accordance the purpose. That is, when the isolator device is used as an aseptic the in chamber set to a pressure higher than an outside air pressure (hereinafter referred to as a positive and even in the case of leakage from chamber, since the air from the chamber side to outside, bacteria and like prevented intruding into the from the outside On the other hand, if the isolator device is to be used as the isolator, the the chamber set a lower than the pressure (hereinafter referred to as a use, and even in the case of the from the since the air flows from the into the chamber, the chemical substances and the in the chamber are prevented from contaminating the outside environment. However, in the isolator device, window through which the of the chamber be checked outside, glove with the worker performs the work, and an opening/closing door by which is carried into the chamber or maintenance works are performed Therefore, is difficult to shield the chamber of isolator in an airtight manner, shielding might operation the device. Moreover, even if air pressure in the chamber adjusted, there is limitation all the time due to various factors such fluctuation of the outside air pressure. If leakage is caused in the isolator device as above, in the aseptic the aseptic/dustless the chamber cannot be maintained, while in the of the containment isolator, chemical substances, microorganisms and the like handled in the might to the environment. As a for avoiding such risk during operation isolator device, Literature discussed cleanliness maintaining device of an isolator in a negative pressure air suction whose negative both to the inside of the chamber and the outside is installed on an edge of a joint provided the chamber, and the air passing
 chamber by the filter and discHarges it to The ouTsiDe. THeRefoRe, suCh isolator deviCE can Be also used basically botH as thE aSEptiC IsOlatoR and the COnTAInmEnT iSolAtOR.
MOreovEr, wHen the iSolator devIce Is To be used, safeTY cAn be furtheR imProved by adjuStiNg an aiR pResSUre in The ChambEr in acCOrdancE with the pUrPOse. ThaT Is, when tHE IsOlatOr device is used as aN AsEPtic isolator, thE pressUrE In THE chAmbEr is set to a PrEssurE Higher tHAn AN OUtsIDe air pressure (Hereinafter REfeRred to As A poSItive pRessuRe), ANd eVen in the casE of lEakage froM the chAMber, sinCE the air Flows fRom The ChamBEr SiDe tO tHE ouTSiDe, aIRboRne bacteRiA aNd the Like ARE PReveNteD froM intrUding into the cHamBer fROm tHe outSide
ON the OtHer haNd, if thE isolAtOr device is to be uSed aS the contaInmEnT isOlAtor, tHE pressUre In tHe chambEr is set TO a pReSSURe Lower than the outsidE aIR PrEssure (heReinafTEr ReFErred to aS a NegAtivE PRessuRe) in USe, And even iN the caSE oF tHe leakaGe From thE cHamBer, Since THe aiR flows From the oUtsidE Into the chamber, THe chemical subSTaNCEs ANd thE liKe in the chamBer aRE preVentED fRom COntamInatiNg THe OUtside environment.
HoWeVer, in tHe isoLator device, a gLass window THROugh whicH the INsIDe of the chamber Can be Visually chECked from OutsiDe, a glove With which THE worker pErfOrmS thE woRK, AnD an opening/cloSINg doOr By which EquIpment iS caRriEd iNto ThE chamber oR maintenAnCe WoRkS arE perfORmed are pRoVidEd. theReforE, It is diFficuLt to CoMpLEteLy shielD ThE CHambEr Of The iSolAtOr devIce iN An aIrtight Manner, and The SHielDiNg PerformAnce might be deStRoyed durinG oPerAtion oF THe isolatOr device. Moreover, even if tHE air preSsuRe in tHe chAmber is adJusTed, theRe iS LimitaTion in ProviDiNg a PREssurE DIfFerEnCe all the tiME Due To varIoUs faCtors suCh as fluctuation of tHE ouTside air pressUre.
if anY LEaKagE Is CAusEd IN thE ISolator device as Above, in the AsEPtIc isolator, THe aSePtic/dusTless stAte in THe chambEr cannot bE maintainEd, WhilE IN thE case of the ContainmEnt isolatOR, the cHEmIcal sUbsTances, MiCroOrganIsms anD The Like hAndled In The chaMber mIgHt leak to The outside environment.
As A methoD for aVoiDing such a RisK DurIng operatIon oF the isolatOr dEviCe, PatEnt lIteraTure 1 DIsCusSEd belOw prOPoses a cleANlIneSS MaIntaining deVICE of An isoLatOR devicE in wHich a negative presSUre air suction pAssaGE WhoSe pREssuRe Becomes negativE boTh TO The insidE oF the chamber And the ouTsIDe is iNstallEd on an Inner peRIPhERal edgE of a JoiNt portion ProViDEd in the ChAmBEr, and tHe aiR pAssing
 chamber by the filter and  discharge s ittothe  o utsi de.Therefore, suc h  iso lator device can be al so us ed basi c al ly bo th as t h ea s ept ic  i sol at o rand t hecontain ment isola tor .Moreover, wh e nthe isolat ordevice is to  be  used,  s afe t y can  be  furt her im p rovedby adjust in g  an ai r  pressu r e  i n th e chamber in acco r da n ce with the pu rpose.  T h at i s,whe n the isol at or de v ice isu se d a s a n  aseptic isol ator, the p r ess ure in  t hec hamber  is s et toa pressurehigh er than a n outs i de airp ressure  (here ina fte r re f er re d t oa s a po sit i vepressure ),  a nd ev en i n t h e ca seof l eakag e from the ch amb er,s inc e the  airflow sfromthe ch amber  s ide to the outs ide,  airborne  ba ct eri aand t h e like  ar e p revente d fromi ntr ud i n g  i nto the chamber fr om t he  outside 
On th e  o th e r hand,if  th e is o l atordevi c eis to be  useda sth e conta in ment i so lat or,  thep ress ure in  the cha mberi s set to a pre s sure lower th a nt h eo utsi deair pressur e (h e rein afte r  r efe r red t o asan eg a tive pressure) in u se , andevenin the case o f the leak a g e  from th e ch a mb e r, since the a ir fl ows from t h e outsid e int o the ch amber, th e chemical  su bst anc esa n dthe like in t h e  cha mb er arepre ventedfro m c ont ami na ting theoutsideen vi ro nm ent .
How e ver, inth e i so lat or de v ice, a  glas s wi nd ow thr ough wh i ch t he i ns id e of  th echamb er c a n b e visua lly check edf romou ts ide, aglove with wh ic h the work er  pe rforms t he work,  and an opening/closing door by  wh ich e quip ment is c arr ied in tot he cha mber o r mai nt ena n c e wor k s  a repe rformed ar e pro vided .Ther efore,it is difficult to com pletely shiel d t he c h a mb ero ft heis o lat o r  device in an a irtight ma nn e r,  and the s h iel di ng perf ormance  migh t  be des troyed du ring oper at iono f  th e isolator  device.  Moreover ,  even if  theair  press ur e i n the  chamb e r i s adj usted,  t here i s lim it ation in  providing a pressure d iffere nce a llthe timedue tovarious f acto rs such as  fl uct uatio n o f  theouts i de  ai r  pres sure . 
If any l e ak age i scaused in t h e iso lator  de v ice as  abo ve, in the asepti c  isolator, the  ase p t ic/ dus t less  s tate in the ch amb er c annot be  m aintained,while in  t h e cas e of t he con tainmen t is o lator,  the  ch emical su bst an c es, mic ro or g anisms  and  t he lik e hand l ed i n the chamber migh t lea k to th e  ou tside  e nvironm e nt.As a metho d for avoid ing su ch a  risk  during  o perati onof  the isola t or device , Pat ent Lit er atur e 1  discu ssed b elowprop os esa cleanli n e ss ma in t ain ingdevic eof a n isolato r  deviceinw hich ane gat i v e pres s ur e air suctio n p assag e whose pres s ureb ec o mes n egativ e both  to the ins id e of th e c h a mber andthe outsi d e i sinst alled on  a n in ne r p er ipheral edge of  a joint  portion p rovide d i n  the chambe r,  and the air  pass in g 
 chamber_by the_filter and discharges it_to the_outside._Therefore, such_isolator_device can be_also used basically_both as the aseptic_isolator and the_containment_isolator.
Moreover, when the isolator device is to be used, safety can be further improved_by_adjusting an_air_pressure_in the chamber in accordance_with the purpose. That is,_when the_isolator device is used as an aseptic isolator,_the_pressure in the_chamber is set to a pressure higher than an_outside air pressure (hereinafter referred to_as a positive_pressure),_and_even in the case_of leakage from the chamber, since_the air flows from the chamber_side to the outside, airborne bacteria and_the like are prevented from intruding_into the chamber from the_outside
On the_other hand, if the isolator_device is to_be used_as the containment_isolator, the pressure in the chamber_is set to_a pressure lower than the outside_air_pressure (hereinafter referred_to_as_a negative_pressure) in use,_and_even in_the_case of the leakage from the_chamber,_since the air flows from the outside_into the chamber, the_chemical_substances and the like_in the chamber are prevented_from contaminating the outside environment.
However, in_the isolator_device, a_glass window through which the inside of the chamber can be_visually checked from outside, a glove_with which the worker_performs the_work,_and an opening/closing_door_by which_equipment is carried into the chamber or_maintenance works_are performed are provided. Therefore, it_is difficult to completely_shield_the chamber of the isolator device_in an airtight manner, and the_shielding performance might be destroyed_during_operation_of the isolator device. Moreover,_even if the air pressure in_the chamber is_adjusted, there is limitation in providing a_pressure_difference all the time due to_various_factors such as fluctuation of the_outside_air_pressure.
If any leakage is caused_in the isolator device as above,_in the aseptic isolator, the aseptic/dustless state in the_chamber cannot be_maintained, while in the case_of_the_containment isolator, the chemical substances, microorganisms and the like handled_in the_chamber might leak_to the outside environment.
As a method for avoiding such a_risk during operation of the isolator device,_Patent Literature 1 discussed below proposes a cleanliness maintaining device of_an isolator device in which a negative pressure_air suction passage whose pressure becomes negative_both to the inside_of_the chamber and the outside is installed_on_an_inner_peripheral edge of_a joint portion_provided in the_chamber, and_the air passing