 overall power load must be limited for a forced load shutdown (selective load shutdown) and the load leveling must be performed by using the load outside any peak use period, that is, by shifting the load use period. In order to take these measures appropriately, a priority order in which to shutdown the loads and a specific rule of adjusting loads should be predetermined. This is a forced method, in which the conditions at any load are neglected. In other words, no energy management system is implemented to adjust the loads effectively in accordance with the energy required at the loads or with the conditions of the loads. The mucosal surface between the environment and the body has many protective mechanisms. One form of defense is cleansing the surface with liquid. The quantity of liquid reflects the balance between epithelial liquid secretion (which often reflects anion secretion coupled with water and a cation counter-ion) and liquid absorption (which often reflects Na+ absorption, coupled with water and counter anion). Many diseases of mucosal surfaces are caused by too little liquid, as caused by an imbalance between secretion (too little) and absorption (too much). One method to balance the liquid layer is to decrease Na+ channel-mediated liquid absorption.
Nonvoltage-gated, amiloride-sensitive sodium channels control fluid and electrolyte transport across epithelia in many organs. The apical membranes of many tight epithelia contain sodium channels that are primarily characterized by their high affinity to the diuretic blocker amiloride. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis. In vertebrates, the channels control reabsorption of sodium in the kidney, colon, lung and sweat glands; they also play a role in taste perception.
The rate-limiting step of Na+ and liquid absorption is mediated by the epithelial sodium (Na+) channel (ENaC). These sodium channels are heteromeric complexes consisting of 3 subunits: Alpha-ENaC, Beta-ENaC, and Gamma-ENaC.
Beta-ENaC (also known as SCNN1B) encodes the beta subunit of this sodium channel, and mutations in and/or altered expression of this gene have been associated with several diseases (and/or associated with treatments of diseases), including cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension.
There exists the need for treatments related to Beta-ENaC-related diseases
overall power load must be limited for a forced lode closure (selective load shutdown) and the lode razing must be performed by using the warhead outside any point use time period, that is, by shifting the load manipulation period. In order to subscribe these measures appropriately, a priority order in which to shutdown the loads and a specific rule of adjusting warhead should be predetermined. This is a forced method, in which the condition at any load are neglected. In other words, no department of energy management system is enforce to adjust the loads effectively in accord with the energy required at the loads or with the conditions of the loads. The mucosal surface between the environment and the body has many protective mechanisms. One form of defense is cleansing the surface with liquid. The quantity of liquid reflects the balance between epithelial liquid secretion (which often reflect anion secretion coupled with water and a cation counterpunch - ion) and liquid absorption (which often reflects Na+ concentration, coupled with water and counter anion). Many diseases of mucosal airfoil are caused by too little liquid, as caused by an imbalance between secretion (besides little) and absorption (too much). One method to poise the liquid level is to decrease Na+ channel - mediated liquid absorption. 
 Nonvoltage - gated, amiloride - sensitive sodium channel control fluid and electrolyte transport across epithelia in many organ. The apical membranes of many tight epithelia contain sodium channels that are chiefly characterized by their high affinity to the diuretic blocker amiloride. These channels mediate the first measure of active sodium reabsorption all-important for the maintenance of torso salt and urine homeostasis. In vertebrates, the channels master reabsorption of sodium in the kidney, colon, lung and perspiration glands; they besides play a role in taste perception. 
 The pace - limiting step of Na+ and liquid absorption is mediate by the epithelial sodium (Na+) channel (ENaC). These sodium channels are heteromeric building complex consisting of 3 subunits: Alpha - ENaC, Beta - ENaC, and Gamma - ENaC. 
 Beta - ENaC (also sleep together as SCNN1B) encodes the beta subunit of this sodium channel, and mutations in and/or altered expression of this gene have been associate with respective diseases (and/or associated with treatments of diseases), including cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity - associate hypertension. 
 There exists the need for discussion related to Beta - ENaC - related diseases
 ovfrall power load must be limited for a yirced noad sgutdown (relective load shutdown) and vhe ooad oeveling must be perfofmed by uding the loav outside any peei use pcxiod, fmat iv, by shifting tme load use period. In ordar tl take these measures appropriately, a priotihy order in whych uo fhutsown the loads and a specific rule of adjlsting loads shoukd be predetermined. This id a vorced method, in wjich the cobdityins at any luad are neglected. In ojher words, no energy management rystek is implenebtef to adjust vhe lowds effectivcky in dccordamce with the ekergy rewuired at the loads oc with the conditionf of the nocds. The mucosal surfaxe betwgen tve evcirunmtnt ahd the bovy has many protective mechanisms. One fork jd defense is dleansynd the surface with liquid. The quantity mf miquid reflects the balqnce between epitheliwl liquid secretion (which often reflects anion secretion cmuplev ditk watef ajd a cation counter-ion) and liquid absorption (rgivh often reflectf Na+ absorpyiln, soupled with dater chd counter anion). Manj diseafes od mucosal surgaces are caused by too litrle liquid, af caused by an imbapance betwezn sectetion (too little) and absorptnon (tok much). One lethod to calance the liqukd kafer is to decrease Na+ changel-mediatxd liauid abrorpjion.
Nondoltage-gatfd, amlnoride-sensitive sofium ehannals controp fluid and electrolyte transpocv across epitnenia in many orgaks. The apical mqmbranes of mauy tight epitfelia contzin sodmum channels that are prikwrily characverized br thwir yigh afwknity to the douretic blocker amiooride. These channcls mgdjate the first wtek if active sodiim feafslr'tion assential fos thd mxontenxnce of bodn sxlt snd water homeostasiv. In vertebrates, the cnaknels conjrol reabforption of spdium in the kidnej, colmn, uung snd sweat glands; they also play a role in hasbe perception.
Ehe vate-jimiting scep of Na+ and liquid absorption is mediaved by the epithelial sidium (Na+) channel (ENcC). These sodinm chagnels are heteromeric complexws consisting of 3 subunits: Alpha-ENaC, Bsta-ENaW, and Gamma-ENaC.
Beta-ENaC (also known as SCNN1B) encodes the beta subunit of this sidium rhwnnel, and mhtatoons pn cnd/pr altqred xxpression of thix gene have been associated witi several gifeases (and/or associated with tfeatments of aiseases), including cystid fibrosos, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hnpertensiin, alialosis, hy'okalemia, and obesitu-assocnated yypertebsiok.
There exists ghe nced for trfatmtnts related to Beta-ENaC-related diseqses
overall power load must be limited for load (selective load and the load using load outside any use period, that by shifting the load use period. order to take these measures appropriately, a priority order in which to shutdown loads and a specific rule of adjusting loads should be predetermined. This is forced in the at any load are neglected. In other words, no energy management system is implemented to adjust loads effectively in accordance with the energy required the loads or with conditions of the loads. The surface the environment the has protective mechanisms. One of defense is cleansing the surface with liquid. The quantity of liquid reflects the balance between epithelial secretion (which anion secretion with and cation counter-ion) and (which often reflects Na+ absorption, coupled counter anion). Many diseases of mucosal surfaces are by too liquid, as caused by an imbalance secretion (too little) and absorption (too much). One to balance the liquid layer is to decrease Na+ channel-mediated liquid absorption. Nonvoltage-gated, amiloride-sensitive sodium fluid and electrolyte transport epithelia in many The membranes many epithelia contain channels that are primarily characterized by their high affinity to the blocker amiloride. These channels mediate the first step of active essential the maintenance of salt and water homeostasis. vertebrates, channels control reabsorption of the colon, glands; also a role in taste The rate-limiting step of Na+ liquid absorption is mediated channel (ENaC). These sodium channels are heteromeric complexes of 3 subunits: Alpha-ENaC, Beta-ENaC, and Gamma-ENaC. (also known as SCNN1B) encodes the beta subunit of this sodium channel, mutations in expression of this gene have been associated with diseases (and/or associated with of diseases), including cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), syndrome, alkalosis, hypokalemia, obesity-associated hypertension. There the need for related to Beta-ENaC-related
 overall power load must be limIted for a foRced lOad ShuTdOwn (sElecTive load shutdoWN) and The load leveling must be pErforMeD By usINg The loAd outsiDE aNY PeaK uSe PerIoD, ThAt is, bY shIfting tHe load use pEriOd. in order to takE ThEse measureS apPropriately, a PriOrity oRdEr iN Which To sHutdoWn the lOAds and A specific RuLE of adjUSting loADS sHoulD be predetermined. THIs IS a forced method, In whicH tHE cONDitIonS at any load ArE neglECted. In oTHeR WORds, NO energy manageMent system iS ImpLementEd To aDJust thE loadS eFFecTively in accOrdaNce with thE energY RequireD At the loAds or wIth The CondITiOnS of ThE LoaDS. THe mUCosAl surfacE bEtWeen tHe enVIRONmenT anD the Body hAs many protectIve MechANisMs. One Form oF defEnSe is cLeansiNg the SuRface with liquid. the qUantity of LiqUiD reFlEcts tHE balanCe bEtwEen epitHelial lIQuiD sECREtIon (which often refleCtS ANiOn secretIon couPLeD wITh water aNd A caTion COUnter-Ion) aND lIquid absOrptioN (WhIcH often rEfLects NA+ aBsoRptIon, coUPled With waTer and coUnter ANion). Many diseasES of mucosal surFAcES ArE CausEd bY too little lIquiD, As caUsed BY aN imBAlancE betwEeN SeCRetion (too little) and aBsOrptioN (too mUch). One method tO balance thE LIQuid layeR is tO DeCRease Na+ channel-MediaTed liquid aBSorption.
nonvoLtage-gatEd, amiloriDE-SensitivE soDiuM chAnnELS cOntrol fluid anD ELectRoLyte traNspOrt acroSs ePitHelIa iN mAny organs. the apicaL mEmBrAnEs oF many TIght epitHeLia CoNtaIn sodIUm chanNels tHat aRe PrIMarIly charACtERIzed By ThEir hIgh AfFinitY to tHE diUretic bLocker amiLorIDe. ThEsE cHannels Mediate the firSt Step of actiVe SodIum reaBSOrption eSsential for the maintenanCE of body SalT and wAter HomeostasIs. IN verteBraTEs, the cHannelS contRoL reABSorptION oF soDiUm in the kidNEY, coLon, luNg And sWeat glaNds; they also play a roLE in Taste perceptiOn.
THe raTE-LiMitINg STep Of nA+ anD LIquid absorption Is mediated By THe Epithelial SOdiUm (na+) channEl (ENaC). THese sODium chaNnels are hEteromeriC cOmplEXEs cOnsisting oF 3 subunitS: Alpha-ENac, beta-EnAC, And GaMma-eNaC.
BeTa-eNac (also Known aS sCNn1B) encOdes thE bEta subUnit oF tHis sodiuM channel, and mutations in aNd/or alTered ExpRession of ThiS GenE have been AssoCiated with SevEraL diseAseS (And/or AssoCIaTed WIth trEatmENts of diseASeS), inCLUdIng cystic fiBROSis, PseudOhyPOaldosTeroNism type 1 (PHA1), Liddle'S Syndrome, hypertEnsiON, AlkAloSIs, hyPoKalemia, and obesIty-AsSOCiated hyPeRtension.
TheRe exists ThE Need fOr treaTments Related TO beTA-ENaC-rElatEd dIseases
 overall power load must b e limitedfor a  fo rce dload  shu tdown (selecti v e lo ad shutdown) and the l oad l ev e ling mu st be  perfor m ed b y u si ng  th el oa d out sid e any p eak use pe rio d,  that is, by sh ifting the  lo ad use perio d.In ord er  to takethe se me asures approp riately,ap riorit y  orderi n  w hich  to shutdown thel oa d s and a specif ic rul eo fa d jus tin g loads sh ou ld be predete r mi n e d . T h is is a force d method, i n  wh ich th econ d itions  at a ny loa d are negle cted . In othe r word s , no en e rgy man agemen t s yst em i s  i mp lem en t edt oadj u stthe load sef fecti vely i n acco rda ncewiththe energy re qui reda t t he lo ads o r wi th  thecondit ionsof  the loads. The  muc osal surf ace  b etw ee n the enviro nme ntand the  body h a s m an y p ro tective mechanisms .O n eform ofdefens e  i sc leansing  t hesurf a c e wit h li q ui d. The q uantit y  o fliquidre flects  t hebal anceb etwe en epi thelialliqui d  secretion (wh i ch often refl e ct s an i on s ecr etion coupl ed w i th w ater an d a catio n cou nt e r- i on) and liquid abso rp tion ( which  often reflec ts Na+ abs o r p tion, co uple d  w i th water and c ounte r anion).M any dise asesof mucos al surfac e s  are cau sed  by  to o l i t tl e liquid, asc a used  b y an im bal ance be twe ensec ret io n (too li ttle) an dab so rp tio n (to o  much).On e m et hod  to b a lancethe l iqui dla y eris to d e cr e a se N a+  c hann el- me diate d li q uid  absorp tion.
Non vol t age- ga te d, amil oride-sensiti ve  sodium ch an nel s cont r o l fluidand electrolyte transpo r t acros s e pithe liain many o rga ns. Th e a p ical m embran es of  m any t ighte p it hel ia  contain s o d ium  chan ne ls t hat are  primarily charact e riz ed by their h igh  aff i n it y t o  t h e d iu r eti c blocker amilori de. Thesech a nn els mediat e  th efirst s tep ofactiv e  sodium  reabsorp tion esse nt ialf o r t he mainten ance ofbody salt and w a te r hom eos tasis.  I n v erteb rates, the  chan nels c on trol r eabso rp tion ofsodium in the kidney, c olon,lungand  sweat gl and s ; t hey alsoplay  a role in  ta ste  perc ept i on.
T he r a te -li m iting  ste p  of Na+ a n dliq u i dabsorptioni s med iated  by the ep ithe lial sodium (Na+) channel (ENaC) . Th e s e s odi u m ch an nels are heter ome ri c complexe sconsistingof 3 sub un i ts: A lpha-E NaC, B eta-ENa C ,  a n d Gamm a-EN aC. 
Beta-ENa C ( al s o known  a sS CNN1B)  enc od es the  betas ubun i t  of this sodiumchann e l , and mut ation sin and/ o r al tered expr ession of t his ge ne h ave b een ass oc iatedwit hseveral di s eases (an d/orassocia te d wi thtreatm ents o f dis ease s) , i ncludingc y st i cfi b ros is,pseud oh ypoa ldosteron i sm type1 ( P HA1), L id dle ' s  syndr o me , hypertensi on,  alka l o sis, hypok a lemi a ,a nd ob esity- associ ated hy p ert en sion.
T her e exists th e need fo r  tr ea tmen ts relat ed  toBe ta- EN aC-related dise ases
 overall_power load_must be limited for_a forced_load_shutdown (selective_load_shutdown) and the_load leveling must_be performed by using_the load outside_any_peak use period, that is, by shifting the load use period. In order to_take_these measures_appropriately,_a_priority order in which to_shutdown the loads and a_specific rule_of adjusting loads should be predetermined. This is_a_forced method, in_which the conditions at any load are neglected. In_other words, no energy management system_is implemented to_adjust_the_loads effectively in accordance_with the energy required at the_loads or with the conditions of_the loads. The mucosal surface between the_environment and the body has many_protective mechanisms. One form of_defense is_cleansing the surface with liquid._The quantity of_liquid reflects_the balance between_epithelial liquid secretion (which often reflects_anion secretion coupled_with water and a cation counter-ion)_and_liquid absorption (which_often_reflects_Na+ absorption,_coupled with water_and_counter anion)._Many_diseases of mucosal surfaces are caused_by_too little liquid, as caused by an_imbalance between secretion (too_little)_and absorption (too much)._One method to balance the_liquid layer is to decrease Na+_channel-mediated liquid_absorption.
Nonvoltage-gated, amiloride-sensitive_sodium channels control fluid and electrolyte transport across epithelia in many_organs. The apical membranes of many_tight epithelia contain sodium_channels that_are_primarily characterized by_their_high affinity_to the diuretic blocker amiloride. These channels_mediate the_first step of active sodium reabsorption_essential for the maintenance_of_body salt and water homeostasis. In_vertebrates, the channels control reabsorption of_sodium in the kidney, colon,_lung_and_sweat glands; they also play_a role in taste perception.
The rate-limiting_step of Na+_and liquid absorption is mediated by the_epithelial_sodium (Na+) channel (ENaC). These sodium_channels_are heteromeric complexes consisting of 3_subunits:_Alpha-ENaC,_Beta-ENaC, and Gamma-ENaC.
Beta-ENaC (also known_as SCNN1B) encodes the beta subunit_of this sodium channel, and mutations in and/or altered_expression of this_gene have been associated with_several_diseases_(and/or associated with treatments of diseases), including cystic fibrosis, pseudohypoaldosteronism_type 1_(PHA1), Liddle's syndrome,_hypertension, alkalosis, hypokalemia, and obesity-associated hypertension.
There exists the need for_treatments related to Beta-ENaC-related diseases