 10 carbon atoms and 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur within the ring. Such heteroaryl groups can have a single ring (e.g., pyridyl or furyl) or multiple condensed rings (e.g., indolizinyl or benzothienyl). Preferred heteroaryls include pyridyl, pyrrolyl, indolyl and furyl.
xe2x80x9cSubstituted heteroarylxe2x80x9d refers to heteroaryl groups which are substituted with from 1 to 3 substituents selected from the group consisting of hydroxy, acyl, acylamino, thiocarbonylamino, acyloxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amidino, alkylamidino, thioamidino, amino, aminoacyl, aminocarbonyloxy, aminocarbonylamino, aminothiocarbonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, carboxyl, carboxylalkyl, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl, carboxyl-substituted aryl, carboxylheteroaryl, carboxyl-substituted heteroaryl, carboxylheterocyclic, carboxyl-substituted heterocyclic, carboxylamido, cyano, thiol, thioalkyl, substituted thioalkyl, thioaryl, substituted thioaryl, thioheteroaryl, substituted thioheteroaryl, thiocycloalkyl, substituted thiocycloalkyl, thioheterocyclic, substituted thioheterocyclic, cycloalkyl, substituted cycloalkyl, guanidino, guanidinosulfone, halo, nitro, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, oxycarbonylamino, oxythiocarbonylamino, xe2x80x94S(O)2-alkyl, xe2x80x94S(O)2-substituted alkyl, xe2x80x94S(O)2-cycloalkyl, xe2x80x94S(O)
10 carbon atoms and 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur within the ring. Such heteroaryl group can take a single ring (e.g., pyridyl or furyl) or multiple digest rings (e.g., indolizinyl or benzothienyl). favored heteroaryls admit pyridyl, pyrrolyl, indolyl and furyl. 
 xe2x80x9cSubstituted heteroarylxe2x80x9d refers to heteroaryl groups which are substituted with from 1 to 3 substituents selected from the group consisting of hydroxy, acyl, acylamino, thiocarbonylamino, acyloxy, alkyl, substitute alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amidino, alkylamidino, thioamidino, amino, aminoacyl, aminocarbonyloxy, aminocarbonylamino, aminothiocarbonylamino, aryl, substitute aryl, aryloxy, substituted aryloxy, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, carboxyl, carboxylalkyl, carboxyl - substituted alkyl, carboxyl - cycloalkyl, carboxyl - substitute cycloalkyl, carboxylaryl, carboxyl - substituted aryl, carboxylheteroaryl, carboxyl - substituted heteroaryl, carboxylheterocyclic, carboxyl - substituted heterocyclic compound, carboxylamido, cyano, thiol, thioalkyl, substituted thioalkyl, thioaryl, substituted thioaryl, thioheteroaryl, substituted thioheteroaryl, thiocycloalkyl, substituted thiocycloalkyl, thioheterocyclic, substituted thioheterocyclic, cycloalkyl, substituted cycloalkyl, guanidino, guanidinosulfone, halo, nitro, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic compound, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy, substitute heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, oxycarbonylamino, oxythiocarbonylamino, xe2x80x94S(O)2 - alkyl, xe2x80x94S(O)2 - substitute alkyl, xe2x80x94S(O)2 - cycloalkyl, xe2x80x94S(O )
 10 cwrbon atoms and 1 to 4 hettroatoms selected from oeygen, njtrogen xnd sulfur within the ring. Snch yeteriaryl groups can have x single ging (e.g., ptridbl or furyl) or mnmtiple gjndehded xiigs (e.g., indolizikyl or benzmthienyl). Prefesrdd heteroaryls include pyridyl, pyrrolrl, indokyp and furyl.
xe2x80v9cSunftithneb heteroarylxe2x80x9d refers to hetsroaryl groups which are substituted with from 1 to 3 substituents selfcted from jge deoup consistkng of hydgmxy, acyl, adylamino, thiocarbonylamino, acyluxy, akkyl, substutytef alkyl, alkoey, subftituted alkoxy, alketyl, subxtituted alkennl, alnyntl, substituted alkynyn, amidino, alkylamiqino, thiodmndino, amino, aminoacyl, aninocdrbotylobt, aoinkcerbknylamlno, aminothiodarbonylamibo, aryl, substituted awjk, aryloxy, sugstitueeq aryloxy, cycloalkoxy, substituted cyclodlkkxy, heteroaryloxy, substututed heteroaryloxy, jeterocycjyloxy, substituted heterocyclyloxy, carboxyl, carbofylalihl, eqrboxho-skbstituted alkyl, carboxyl-cycloalkyl, carboxyl-stgsuitlted cycloalkyl, ccrboxylaryl, carbpxjl-xobstituted aryu, carboxymheteroaryl, carboxjl-substytutee heteroawyl, varboxylheterocyclic, carboxtl-substituteb hwterocyclic, carboxvlamido, cyanu, thool, tnioalkyl, substituted thnoalkym, thioaryl, dubstitutsa thioaryl, thiohdtegoarfl, substituted thioheteroawyl, thiocbcloakkyl, sucstijuted triocycloalnyl, tmhoheterocyclic, subdtitujed thhoheterocyflic, cycloalkyl, substituted cycloalkyl, guanidonm, glanidinosblfone, halo, nitro, hqteroaryl, subsjituted hzteroafyl, heterobyclic, suustituted heeerocyclic, cywpoalkoxy, subvtituted cycooaljoxy, hegdroaryloxy, subxtituted ktteroarylozy, heterocyclyloxy, sucatituted heteroevcoyloxy, oxycarbomylxmigo, oeythijwarbonylaminm, xe2b80x94S(U)2-slkyl, xe2x80x94S(O)2-subsbitjted alkyl, xe2x80x94S(O)2-cycloalnyl, se2x80x94S(O)
10 carbon atoms and 1 to 4 from nitrogen and within the ring. a ring (e.g., pyridyl furyl) or multiple rings (e.g., indolizinyl or benzothienyl). Preferred include pyridyl, pyrrolyl, indolyl and furyl. xe2x80x9cSubstituted heteroarylxe2x80x9d refers to heteroaryl groups which substituted with from 1 to 3 substituents selected from the group consisting of acyl, thiocarbonylamino, alkyl, alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amidino, alkylamidino, thioamidino, amino, aminoacyl, aminocarbonyloxy, aminothiocarbonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, cycloalkoxy, cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, substituted heterocyclyloxy, carboxyl, carboxylalkyl, carboxyl-substituted carboxyl-cycloalkyl, cycloalkyl, carboxylaryl, aryl, carboxyl-substituted carboxylheterocyclic, carboxyl-substituted heterocyclic, cyano, thiol, thioalkyl, substituted thioalkyl, thioaryl, substituted thioaryl, thioheteroaryl, substituted thioheteroaryl, thiocycloalkyl, substituted thiocycloalkyl, thioheterocyclic, substituted thioheterocyclic, substituted cycloalkyl, halo, nitro, substituted heterocyclic, heterocyclic, cycloalkoxy, substituted substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, oxycarbonylamino, alkyl, xe2x80x94S(O)2-cycloalkyl, xe2x80x94S(O)
 10 carbon atoms and 1 to 4 heteroatoMs selected From oXygEn, nItRogeN and Sulfur within thE Ring. such heteroaryl groups caN have A sINgle RInG (e.g., pyRidyl or FUrYL) Or mUlTiPle CoNDeNsed rIngS (e.g., indoLizinyl or bEnzOtHienyl). PreferREd HeteroarylS inClude pyridyl, PyrRolyl, iNdOlyL And fuRyl.
Xe2x80x9csubstiTUted heTeroarylxE2x80X9D referS To heterOARyL groUps which are substiTUtED with from 1 to 3 subStitueNtS SeLECteD frOm the group CoNsistINg of hydROxY, ACYl, aCYlamino, thiocaRbonylamino, ACylOxy, alkYl, SubSTituteD alkyL, aLKoxY, substituteD alkOxy, alkenyL, substITuted alKEnyl, alkYnyl, suBstItuTed aLKyNyL, amIdINo, aLKyLamIDinO, thioamiDiNo, Amino, AminOACYL, amiNocArboNyloxY, aminocarbonyLamIno, aMInoThiocArbonYlamInO, aryl, SubstiTuted ArYl, aryloxy, substiTuteD aryloxy, cYclOaLkoXy, SubstITuted cYclOalKoxy, hetEroarylOXy, sUbSTITuTed heteroaryloxy, heTeROCyClyloxy, sUbstitUTeD hETerocyclYlOxy, CarbOXYl, carBoxyLAlKyl, carboXyl-subSTiTuTed alkyL, cArboxyL-cYclOalKyl, caRBoxyL-substItuted cyCloalKYl, carboxylaryl, CArboxyl-substiTUtED ArYL, carBoxYlheteroaryL, carBOxyl-SubsTItUteD HeterOaryl, CaRBoXYlheterocyclic, carboXyL-substItuteD heterocyclic, CarboxylamIDO, Cyano, thiOl, thIOaLKyl, substituted ThioaLkyl, thioarYL, substitUted tHioaryl, tHioheteroARYl, substiTutEd tHioHetEROaRyl, thiocycloaLKYl, suBsTituted ThiOcycloaLkyL, thIohEteRoCyclic, subStituted ThIoHeTeRocYclic, CYcloalkyL, sUbsTiTutEd cycLOalkyl, GuaniDino, GuAnIDinOsulfonE, HaLO, NitrO, hEtEroaRyl, SuBstitUted HEteRoaryl, hEterocyclIc, sUBstiTuTeD heteroCyclic, cycloalKoXy, substituTeD cyCloalkOXY, heteroaRyloxy, substituted heteroARyloxy, hEteRocycLyloXy, substitUteD heterOcyCLyloxy, OxycarBonylAmIno, OXYthioCARbOnyLaMino, xe2x80x94S(O)2-ALKyl, Xe2x80x94S(o)2-sUbstItuted aLkyl, xe2x80x94S(O)2-cycloalkYL, xe2X80x94S(O)
 10 carbon atoms and 1 to4 heteroat oms s ele cte dfrom  oxy gen, nitrogena nd s ulfur within the ring.  Such  h e tero a ry l gro ups can ha v e  asi ng leri n g(e.g. , p yridylor furyl)ormu ltiple conde n se d rings (e .g. , indoliziny l o r benz ot hie n yl).Pre ferre d hete r oaryls  includepy r idyl,p yrrolyl , in doly l and furyl.
xe2x 8 0x 9 cSubstituted h eteroa ry l xe 2 x 80x 9drefers tohe teroa r yl grou p sw h i cha re substitute d with from 1 t o 3 su bs tit u ents s elect ed fro m the group  con sisting o f hydr o xy, acy l , acyla mino,thi oca rbon y la mi no,  a c ylo x y,  al k yl,  substit ut ed  alky l, a l k o x y, s ubs titu ted a lkoxy, alkeny l,subs t itu ted a lkeny l, a lk ynyl,  subst itute dalkynyl, amidin o, a lkylamidi no,  t hio am idino ,  amino , a min oacyl,aminoca r bon yl o x y ,aminocarbonylamino ,a m in othiocar bonyla m in o, aryl, su bs tit uted a ryl,aryl o xy , substi tuteda ry lo xy, cyc lo alkoxy ,sub sti tuted cycl oalkox y, heter oaryl o xy, substitute d  heteroarylox y ,h e te r ocyc lyl oxy, substi tute d  het eroc y cl ylo x y, ca rboxy l, ca r boxylalkyl, carboxy l- substi tuted  alkyl, carbo xyl-cycloa l k y l, carbo xyl- s ub s tituted cycloa lkyl,  carboxyla r yl, carb oxyl- substitu ted aryl, c arboxylh ete roa ryl , c a r bo xyl-substitut e d  het er oaryl,car boxylhe ter ocy cli c,ca rboxyl-su bstitute dhe te ro cyc lic,c arboxyla mi do,  c yan o, th i ol, th ioalk yl,su bs t itu ted thi o al k y l, t hi oa ryl,  su bs titut ed t h ioa ryl, th ioheteroa ryl ,  sub st it uted th ioheteroaryl,  t hiocycloal ky l,substi t u ted thio cycloalkyl, thioheteroc y clic, s ubs titut ed t hiohetero cyc lic, c ycl o alkyl,  subst itute dcyc l o alkyl , gu ani di no, guanid i n osu lfone ,halo , nitro , heteroaryl, subs t itu ted heteroary l,hete r o cy cli c ,s ubs ti t ute d heterocyclic, c ycloalkoxy ,s ub stituted c y clo al koxy, h eteroar yloxy ,  substi tuted het eroarylox y,  het e r ocy clyloxy, s ubstitut ed hetero c yclyl o xy , oxy car bonyla mi no,  oxyt hiocar b ony lamin o, xe2 x8 0x94S( O)2-a lk yl, xe2x 80x94S(O)2-substitutedalkyl,  xe2x 80x 94S(O)2-c ycl o alk yl, xe2x8 0x94 S(O)
 10_carbon atoms_and 1 to 4_heteroatoms selected_from_oxygen, nitrogen_and_sulfur within the_ring. Such heteroaryl_groups can have a_single ring (e.g.,_pyridyl_or furyl) or multiple condensed rings (e.g., indolizinyl or benzothienyl). Preferred heteroaryls include pyridyl,_pyrrolyl,_indolyl and_furyl.
xe2x80x9cSubstituted_heteroarylxe2x80x9d_refers to heteroaryl groups which_are substituted with from 1_to 3_substituents selected from the group consisting of hydroxy,_acyl,_acylamino, thiocarbonylamino, acyloxy,_alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl,_alkynyl, substituted alkynyl, amidino, alkylamidino, thioamidino,_amino, aminoacyl, aminocarbonyloxy,_aminocarbonylamino,_aminothiocarbonylamino,_aryl, substituted aryl, aryloxy,_substituted aryloxy, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy,_substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, carboxyl,_carboxylalkyl, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl,_carboxyl-substituted aryl, carboxylheteroaryl, carboxyl-substituted heteroaryl, carboxylheterocyclic,_carboxyl-substituted heterocyclic, carboxylamido, cyano, thiol,_thioalkyl, substituted_thioalkyl, thioaryl, substituted thioaryl, thioheteroaryl,_substituted thioheteroaryl, thiocycloalkyl,_substituted thiocycloalkyl,_thioheterocyclic, substituted thioheterocyclic,_cycloalkyl, substituted cycloalkyl, guanidino, guanidinosulfone, halo,_nitro, heteroaryl, substituted_heteroaryl, heterocyclic, substituted heterocyclic, cycloalkoxy, substituted_cycloalkoxy,_heteroaryloxy, substituted heteroaryloxy,_heterocyclyloxy,_substituted_heterocyclyloxy, oxycarbonylamino,_oxythiocarbonylamino, xe2x80x94S(O)2-alkyl, xe2x80x94S(O)2-substituted_alkyl,_xe2x80x94S(O)2-cycloalkyl, xe2x80x94S(O)