 drugs and chemicals that preferentially sensitize hypoxic tumor cells to radiation, radiosensitizers, are employed. Radiosensitizers normally are chemical agents that have the capacity to increase the lethal effects of radiation when administered in conjunction with radiation and there are a variety of radiosensitizers that act by more than one mechanism. Furthermore, in the treatment of cancer with radiation and chemotherapy, local tumor control is often improved when radiation is administered synchronously with the chemotherapeutic agent (21). This observation has been attributed to a super additive effect on tumor regression due to a synergistic interaction between the radiation and the drug. Nevertheless, despite the above improvements in cancer treatment, cancer remains difficult to treat and cells still become resistant to radiation therapy.
Thus, alternative methods and compositions which will increase the sensitivity of cancer cells to radiation therapy, thereby allowing for less exposure to toxic chemotherapeutic agents and radiation therapy, reduced side-effects and improved beneficial results, are still desirable. The present invention seeks to meet these and other needs.
The present description refers to a number of documents, the content of which is incorporated by reference in their entirety. An object of the present invention is a process for representing views of an object. This object has to be discriminated in a digital volume. A digital volume results from the acquisition and storage of pieces of information concerning physical characteristics of internal parts of an examined body. The best known mode of acquisition of this information is the tomographic mode. This mode may be performed, especially in the medical field, by various means: nuclear magnetic resonance, tomodensitometry by X-rays, or tomography by gammagraphy or ultrasonic tomography. This acquisition mode may, of course, also be any mode, once it leads to a gathering of pieces of physical information that can be arranged virtually with respect to one another along three orthogonal axes of reference and are supposed to represent, in the virtual position that they occupy, the physical characteristics of corresponding parts in an examined body. Each volume element of this digital volume thus has at least two types of information. A first type concerns the coordinates of a corresponding place in the body (corresponding biuniquely to an address in a storage memory of a computer). The other type represents the value of the physical information which has been assigned to this place and which has been measured, for example by one of the above-mentioned techniques of tomography.
Techniques for the representation of views of objects to be discriminated in digital volumes are already known. There are chiefly two of them. A first technique, developed mainly by G.
drugs and chemicals that preferentially sensitize hypoxic tumor cells to radiation, radiosensitizers, are use. Radiosensitizers normally are chemical agent that have the capacity to increase the lethal impression of radiation when administered in concurrence with radiation and there are a assortment of radiosensitizers that act by more than one mechanism. Furthermore, in the treatment of cancer with radiotherapy and chemotherapy, local tumor control is often better when radiation sickness is administered synchronously with the chemotherapeutic agent (21). This observation has been attributed to a super linear effect on tumor regression due to a synergistic interaction between the radiotherapy and the drug. Nevertheless, despite the above improvements in cancer discussion, cancer remains unmanageable to treat and cells still become resistant to radiation therapy. 
 Thus, alternate methods and compositions which will increase the sensitivity of cancer cells to radiation therapy, thereby allowing for less exposure to toxic chemotherapeutic agent and radiotherapy therapy, reduced side - effects and improved beneficial results, are still desirable. The present invention seeks to meet these and early need. 
 The present description refers to a issue of document, the content of which is incorporated by reference in their entirety. An aim of the present invention is a process for constitute views of an object. This aim has to be discriminated in a digital volume. A digital volume results from the acquisition and storage of pieces of information concerning physical characteristics of inner parts of an test body. The best known mode of acquisition of this data is the tomographic mode. This mode may be performed, especially in the medical field, by various means: nuclear magnetic rapport, tomodensitometry by X - ray, or tomography by gammagraphy or ultrasonic imaging. This acquisition mode may, of course, also be any manner, once it leads to a gather of pieces of physical data that can be arranged virtually with respect to one another along three orthogonal axes of reference and are supposed to represent, in the virtual position that they occupy, the physical characteristics of match parts in an examined torso. Each volume element of this digital volume thus has at least two types of data. A first type concerns the coordinates of a corresponding place in the body (corresponding biuniquely to an savoir-faire in a storage memory of a computer). The other type represents the value of the physical information which has been assigned to this topographic point and which has been measured, for example by one of the above - mentioned proficiency of tomography. 
 Techniques for the representation of views of objects to be discriminate in digital volumes are already known. There are chiefly two of them. A first technique, developed chiefly by G.
 drkgs and chemicals that pveferentially seuwitize hypoxjc tumor cells to radiation, radiosendirizerw, are employed. Radiosevsitizers normallt art chemical agents that hayz the gapacntb to increase tme lethal exfects of radidtkou when administered in conjunction wyth radoahion and there are w vadpeuy of radiosensitizers that act bg more uhan one mechanism. Furthermore, in the treatmfnt lf cancer with radlation and xhemjrherapy, locau tumor control is oftgn improved when radiation is adoiniscered synchtohokvly with thx chemjtherapeutic agent (21). Dhis obxervation has neen ettrubuted to a super addmtive effect on tumot regressimn due to a synergiwtuc injeracdion vetdeeh vhe radiahioi and the ddug. Neverthwless, despite the anodv improvementa in cwnser treatment, cancer remains difficult uo trsat and cells still becime resistant to radiwtion thewapy.
Thus, alternative methods and compositions whiwh wimu iugveasd tje sensitivity of cancer cells to radiation trsrspj, thereby allowinn for less exposurr ho joxic chemothetapeutie afents and radiatioj theraky, redyced side-tffecys and improved beneficial eesults, are frill desirable. The present inrentiom seels to meet these and otker nesds.
The presfnt descrjotion refers to x nlmbes of documents, the content of which is nncorporxted by reserence in theiv entirety. An objech of jhe prasent invejtion is a process for represenvmng views of sn obbect. Thif objcct has to be dyscriminated iu a digical vouume. A digptal voluke results srom the acquhdition and svorage of piexes if infofoation concernong physibaj chqracteristics of ikternxm parts of an ercmuned body. The brst knjwj koqa of acquisidion of yhis knformaunon ks tne tomographic mode. Dhis mode may be perfotmcd, especiqlly in ehe medical foeld, by various mewns: nnclear magnrtis resonance, tomodensitometry bg X-rays, og tjmography by gamnagraphy or bltrasonic tomography. This acquisition mide may, of course, qlso be any mode, onee it leads tp a gwthering mf pieces of physicao information thau can be arranged virtuzlly whth rfspect to one another along three orthogonal axes of reference and are supposed to represenf, in the nircuak posieion vhat they occupy, nhe physical characteristics of rorrespondhny parts in an examined body. Escf volume elemgnt of this digital volume thus hax at least two types of informayion. A first type concerks the coirdinztes of a rorresponding place on the body (correspondlng biuniquely to ak address ln a scorage memory of a computer). The orher ttpf represents the value of tme physpcal insormation which gas gfen arsigned to thos place and wnich has been measurvd, sor example by kne of the anove-mgunioned techniaues of tommgraphy.
Techniques for the representation of views or objects to be dlscriminated in dojital volumes are alreadn knorn. There are chiefly two of them. A first technique, developed mammly bh G.
drugs and chemicals that preferentially sensitize hypoxic to radiosensitizers, are Radiosensitizers normally are capacity increase the lethal of radiation when in conjunction with radiation and there a variety of radiosensitizers that act by more than one mechanism. Furthermore, in treatment of cancer with radiation and chemotherapy, local tumor control is often improved radiation administered with chemotherapeutic agent (21). This observation has been attributed to a super additive effect on tumor regression to a synergistic interaction between the radiation and drug. Nevertheless, despite the improvements in cancer treatment, cancer difficult treat and still resistant radiation therapy. Thus, methods and compositions which will increase the sensitivity of cancer cells to radiation therapy, thereby allowing for exposure to agents and therapy, side-effects improved beneficial results, desirable. The present invention seeks to other needs. The present description refers to a of documents, content of which is incorporated by in their entirety. An object of the present is a process for representing views of an object. This object has to be discriminated digital volume. A digital results from the and of of concerning physical of internal parts of an examined body. The best known mode acquisition of this information is the tomographic mode. This mode performed, in the medical by various means: nuclear resonance, by X-rays, or tomography or tomography. may, course, be any mode, once leads to a gathering of of physical information that respect to one another along three orthogonal axes reference and are supposed to represent, in virtual position that they occupy, the physical characteristics of corresponding parts in examined body. element of this digital volume thus has at two types of information. first type concerns the coordinates of a corresponding place the (corresponding biuniquely an address in storage memory of computer). The other the value the information assigned to this place and which been for example by one of above-mentioned tomography. Techniques for the representation of views of objects to be discriminated in digital volumes known. There are chiefly of A first technique, developed mainly by G.
 drugs and chemicals that prefErentially SensiTizE hyPoXic tUmor Cells to radiatiON, radIosensitizers, are employEd. RadIoSEnsiTIzErs noRmally aRE cHEMicAl AgEntS tHAt Have tHe cApacity To increase The LeThal effects oF RaDiation wheN adMinistered in ConJunctiOn WitH RadiaTioN and tHere arE A varieTy of radioSeNSitizeRS that acT BY mOre tHan one mechanism. FuRThERmore, in the treaTment oF cANcER WitH raDiation and ChEmothERapy, locAL tUMOR coNTrol is often imProved when rADiaTion is AdMinIStered SynchRoNOusLy with the chEmotHerapeutiC agent (21). tHis obseRVation hAs been AttRibUted TO a SuPer AdDItiVE eFfeCT on Tumor regReSsIon duE to a SYNERgisTic InteRactiOn between the rAdiAtioN And The drUg. NevErthElEss, deSpite tHe aboVe Improvements in cAnceR treatmenT, caNcEr rEmAins dIFficulT to TreAt and ceLls stilL BecOmE RESiStant to radiation thErAPY.
THus, alterNative MEtHoDS and compOsItiOns wHICh wilL incREaSe the senSitiviTY oF cAncer ceLlS to radIaTioN thErapy, THereBy alloWing for lEss exPOsure to toxic chEMotherapeutic AGeNTS aND radIatIon therapy, rEducED sidE-effECtS anD ImproVed beNeFIcIAl results, are still deSiRable. THe preSent invention Seeks to meeT THEse and otHer nEEdS.
the present descRiptiOn refers to A Number of DocumEnts, the cOntent of wHICh is incoRpoRatEd bY reFEReNce in their entIREty. AN oBject of The Present InvEntIon Is a PrOcess for rEpresentInG vIeWs Of aN objeCT. This objEcT haS tO be DiscrIMinateD in a dIgitAl VoLUme. a digitaL VoLUMe reSuLtS froM thE aCquisItioN And Storage Of pieces oF inFOrmaTiOn ConcernIng physical chArActeristicS oF inTernal PARts of an eXamined body. The best known MOde of acQuiSitioN of tHis informAtiOn is thE toMOgraphIc mode. this mOdE maY BE perfORMeD, esPeCially in thE MEdiCal fiElD, by vArious mEans: nuclear magnetiC ResOnance, tomodenSitOmetRY By x-raYS, oR TomOgRAphY BY gammagraphy or uLtrasonic tOmOGrAphy. This acQUisItIon mode May, of coUrse, aLSo be any Mode, once iT leads to a GaTherING of Pieces of phYsical inFormation THat caN Be ArranGed VirtuaLlY wiTh resPect to ONe aNotheR along ThRee ortHogonAl Axes of reFerence and are supposed to RepresEnt, in The Virtual poSitIOn tHat they ocCupy, The physicaL chAraCteriStiCS of coRresPOnDinG Parts In an EXamined boDY. EAch VOLuMe element of THIS diGital VolUMe thus Has aT least two types of iNFormation. A firsT typE COncErnS The cOoRdinates of a corResPoNDIng place In The body (corrEspondinG bIUniquEly to aN addreSs in a stORAgE Memory Of a cOmpUter). The otHer TyPE represEnTs THe valuE of tHe PhysicAl infoRMatiON Which has been assiGned tO THis plACe aNd whiCh Has been MEasuRed, for examPle by one of tHe abovE-menTioneD techniQuEs of toMogRaPhy.
TechniqUEs for the rEpresEntatioN oF vieWs oF objecTs to BE DiscrIminAtEd iN digital vOLUmES aRe ALreAdy kNown. THeRe arE chiefly tWO of them. A FirST techniQuE, deVELoped mAInLY By G.
 drugs and chemicals thatpreferenti allysen sit iz e hy poxi c tumor cellst o ra diation, radiosensitiz ers,ar e  emp l oy ed. R adiosen s it i z ers  n or mal ly ar e che mic al agen ts that ha veth e capacity t o  i ncrease th e l ethal effect s o f radi at ion whenadm inist ered i n  conju nction wi th radiat i on andt h er e ar e a variety of ra d io s ensitizers tha t actby mo r e  th anone mechan is m. Fu r thermor e ,i n the treatment ofcancer with rad iation  a ndc hemoth erapy ,l oca l tumor con trol  is often  impro v ed when radiati on isadm ini ster e dsy nch ro n ous l ywit h  th e chemot he ra peuti c ag e n t (21) . T hisobser vation has be enattr i but ed to  a su perad ditiv e effe ct on  t umor regression  due  to a syn erg is tic  i ntera c tion b etw een  the ra diation and  t h e dr ug. Nevertheless,de s p it e the ab ove im p ro ve m ents inca nce r tr e a tment , ca n ce r remain s diff i cu lt  to tre at  and c el lssti ll be c omeresist ant to r adiat i on therapy.
Th u s, alternativ e  m e t ho d s an d c ompositions  whi c h wi ll i n cr eas e  thesensi ti v it y  of cancer cells to  r adiati on th erapy, thereb y allowing f o r less e xpos u re to toxic chemo thera peutic age n ts and r adiat ion ther apy, redu c e d side-e ffe cts  an d i m p ro ved beneficia l resu lt s, aresti ll desi rab le.  Th e p re sent inve ntion se ek sto  m eet  thes e  and oth er  ne ed s.The p r esentdescr ipti on  r e fer s to an um b e r of  d oc umen ts,  t he co nten t  of  whichis incorp ora t ed b yre ference  in their ent ir ety. An ob je ctof the p resent i nvention is a process f o r repre sen tingview s of an o bje ct. Th iso bjecthas to  be d is cri m i nated i na d ig ital volum e .  Adigit al  vol ume res ults from the acqu i sit ion and stora geof p i e ce s o f  i n for ma t ion c oncerning physi cal charac te r is tics of in t ern al  partsof an e xamin e d body.  The best  known mo de  ofa c qui sition ofthis inf ormationi s the to mogra phi c mode .Thi s mod e mayb e p erfor med, e sp eciall y inth e medica l field, by various mea ns: nu clear  ma gnetic re son a nce , tomoden sito metry by X -ra ys,  or t omo g raphy  byg am mag r aphyor u l trasonict om ogr a p hy . This acqu i s i tio n mod e m a y, ofcour se, also be any m o de, once it le adst o  agat h erin gof pieces of p hys ic a l  informa ti on that can  be arra ng e d vir tually  withrespect t oo ne ano ther  al ong three  or th o gonal a xe so f refe renc eand ar e supp o sedt o  represent, in t he vi r t ual p o sit ion t ha t theyo ccup y, the phy sical chara cteris tics  of c orrespo nd ing pa rts  i n an exami n ed body.Eachvolumeel emen t o f this  dig i t al vo lume  t hus  has at l e a st tw ot ype s of  info rm atio n. A firs t  type co nce r ns theco ord i n ates o f  a c orrespondi ngplace i n the body (cor r es p ondin g biun iquely  to ana ddr es s in asto r a ge memory  of a com p ute r) . Th e otherty pe r ep res en ts the value of  the phy sical in f o rmatio n w h ichh as bee nassigned tothispl a ce andw h ich  has be e n m eas ure d, f orexam p le by one of the above-m enti onedt ech nique s ofto mography . 
Tec hniquesf or the repres entation of vie w s o f  obj ect s  t obe discri min a ted i n di git al v olu mesa r e al r eady kn own.  There  are  c hi efly twoof  them.A  fir s t t echn ique,  d ev e lo ped mai nly by G .
 drugs_and chemicals_that preferentially sensitize hypoxic_tumor cells_to_radiation, radiosensitizers,_are_employed. Radiosensitizers normally_are chemical agents_that have the capacity_to increase the_lethal_effects of radiation when administered in conjunction with radiation and there are a variety_of_radiosensitizers that_act_by_more than one mechanism. Furthermore,_in the treatment of cancer_with radiation_and chemotherapy, local tumor control is often improved_when_radiation is administered_synchronously with the chemotherapeutic agent (21). This observation has_been attributed to a super additive_effect on tumor_regression_due_to a synergistic interaction_between the radiation and the drug._Nevertheless, despite the above improvements in_cancer treatment, cancer remains difficult to treat_and cells still become resistant to_radiation therapy.
Thus, alternative methods and_compositions which_will increase the sensitivity of_cancer cells to_radiation therapy,_thereby allowing for_less exposure to toxic chemotherapeutic agents_and radiation therapy,_reduced side-effects and improved beneficial results,_are_still desirable. The_present_invention_seeks to_meet these and_other_needs.
The present_description_refers to a number of documents,_the_content of which is incorporated by reference_in their entirety. An_object_of the present invention_is a process for representing_views of an object. This object_has to_be discriminated_in a digital volume. A digital volume results from the acquisition_and storage of pieces of information_concerning physical characteristics of_internal parts_of_an examined body._The_best known_mode of acquisition of this information is_the tomographic_mode. This mode may be performed,_especially in the medical_field,_by various means: nuclear magnetic resonance,_tomodensitometry by X-rays, or tomography by_gammagraphy or ultrasonic tomography. This_acquisition_mode_may, of course, also be_any mode, once it leads to_a gathering of_pieces of physical information that can be_arranged_virtually with respect to one another_along_three orthogonal axes of reference and_are_supposed_to represent, in the virtual_position that they occupy, the physical_characteristics of corresponding parts in an examined body. Each_volume element of_this digital volume thus has_at_least_two types of information. A first type concerns the coordinates_of a_corresponding place in_the body (corresponding biuniquely to an address in a storage_memory of a computer). The other type_represents the value of the physical information which has been assigned_to this place and which has been measured,_for example by one of the above-mentioned_techniques of tomography.
Techniques for_the_representation of views of objects to be_discriminated_in_digital_volumes are already_known. There are_chiefly two of_them. A_first technique, developed_mainly by_G.