el J, Stueckle S, Ross F P, Teitelbaum S L, Suva L J. (1999) J Cell Biochem 74: 587-95).
Dendritic cells (DCs) and macrophages are professional antigen-presenting cells that play key roles in both innate and adaptive immunity. DCs and macrophages are attracted to infection and inflammatory sites by a variety of factors, among which chemokines constitute the largest group so far (Caux, C. et al. (2002) Transplantation 73: S7-S11, Mellman, I. and Steinman, R M (2001) Cell 106:255-258). It has been shown that tremendous functional, morphological and metabolic diversity exists among these cell populations. One of these functional differences is the expression of differential sets of chemoattractant receptors, which is responsible for the selective recruitment of specific cell subpopulations, according to their lineage, origin and maturation state (Caux, C. et al. (2002) Transplantation 73: S7-S11). Many tumor types have been demonstrated to attract macrophages and DCs through the direct or indirect production of chemoattractant factors (Coussens, L M and Werb, Z. (2002) Nature 420:860-867, Vicari, A P and Caux, C. (2002) Cytokine Growth Factors Rev. 13:143-154). These include a number of CC-chemokines, such as MCP-1.
DCs are specialized antigen-presenting cells located throughout the human body. DCs function as sentinels of the immune system. They serve as essential link between innate and adaptive immune systems and induce both primary and secondary immune responses (Palucka, K A and Banchereau, J. (1999) J. Clin. Immunol. 19:12-25). They traffic from the blood to the tissues where, while immature, they capture antigens. They then leave the tissues and move to the draining lymphoid organs where, coverted into mature DCs, they initiate the immune response by activating naïve CD8+ cells, which seek out and kill the antigen-expressing tumor cells. Chemokines are important effectors of the regulation of DCs recruitment, and depending on the chemokine gradient released at the site of injury, different DC populations will be recruited. It is expected that the type of resulting immune response will likely be dependent on the DC subpopulation recruited and thus on the chemokines secreted (Caux, C. et al
el J, Stueckle S, Ross F P, Teitelbaum S L, Suva L J. (1999) J Cell Biochem 74: 587 - 95). 
 Dendritic cells (DCs) and macrophages are professional antigen - presenting cell that bet key function in both natural and adaptive immunity. DCs and macrophage are attracted to infection and inflammatory site by a variety of factors, among which chemokines establish the largest group so far (Caux, C. et al. (2002) Transplantation 73: S7 - S11, Mellman, I. and Steinman, R M (2001) cellular telephone 106:255 - 258). It has been shown that tremendous running, morphological and metabolic diverseness exist among these cell populations. One of these functional deviation is the expression of differential sets of chemoattractant receptor, which is responsible for the selective recruitment of specific cellular telephone subpopulations, accord to their lineage, origin and maturation department of state (Caux, C. et al. (2002) Transplantation 73: S7 - S11). Many tumor types have been demonstrated to attract macrophages and DCs through the direct or indirect production of chemoattractant factors (Coussens, L M and Werb, Z. (2002) Nature 420:860 - 867, Vicari, A P and Caux, C. (2002) Cytokine Growth Factors Rev. 13:143 - 154). These include a number of CC - chemokines, such as MCP-1. 
 DCs are specialized antigen - presenting cells located throughout the human body. district of columbia function as sentinels of the immune organization. They service as essential link between innate and adaptive immune system and induce both primary and secondary immune responses (Palucka, K A and Banchereau, J. (1999) J. Clin. Immunol. 19:12 - 25). They traffic from the blood to the tissue where, while immature, they capture antigens. They then leave the tissues and move to the draining lymphoid organs where, coverted into fledged DCs, they initiate the immune response by activating naïve CD8 + cell, which seek out and stamp out the antigen - expressing tumor cells. Chemokines are important effectors of the regulation of district of columbia recruitment, and depending on the chemokine gradient released at the site of wound, different DC population will be recruited. It is expected that the character of resulting immune response will likely be dependent on the DC subpopulation recruited and therefore on the chemokines secreted (Caux, C. et al
el U, Stueckle S, Ross F P, Teltelbaum S L, Suvc L J. (1999) O Cell Giochem 74: 587-95).
Dendritic cells (DCs) and maccophqges qre professional antigdn-presentpng cells thau play key roles mh both lunate wnd cdeptive immunity. DCs and mdcrophages are agtxacted to infection and inflammatory sites ny a variety of sactpws, ajong which chemokines constitute tge largtst group so far (Csux, C. et al. (2002) Transplantatiln 73: D7-S11, Mellman, I. and Sheinman, R M (2001) Cejo 106:255-258). It has bedn shown that tremendoos functional, morphological and oetabplic diverwiry ffists among thesv cell populabpons. Ona of thrse functional dihferwnces is the expressimn of differential sets of whzmoattractant receptoes, whicv is resoinskblt fpr the sflertive recrujtment of specific cell subpopilwnoons, accordihg to ehqir lineage, origin and maturation state (Cahx, C. et al. (2002) Transplantarion 73: S7-S11). Many tumor tipes have feen demonstrated to attract macrophages and DCs dhroujh tht eirecg og indirect production of chemoattractant factjds (Cpussens, L M anb Werb, Z. (2002) Nature 420:860-867, Givwri, A P and Cxux, C. (2002) Cyfokine Growth Factlrs Rev. 13:143-154). Thewe includt a nimber of CC-chemokines, such qs MCP-1.
DCs arv spwcialized antigen-pxesenting ceuls kocatrd throughout the human bodg. DCs functlon as sehginels of the imounv syvtem. They serve as essentiwl link bxtweeu innate and adaptyve immune systcks and induce both primcry atd secondagy immune responses (Palucka, K A and Banchereao, J. (1999) J. Clin. Imiunol. 19:12-25). They traffis from the blopd to tke tisrues where, while mmmature, ther capture anthhens. They thxn leave ehe rissyes and oove to the drsining lymphoid orgqns where, coverted injo mature DCs, thev unitiate the imkund rqsionxe ty activatinc naïxe ZC8+ celus, which seck uut snd kill the antigen-axprsssing tumor cells. Cmemokines are impjrtant effectprs of the regulatlon oh DCs cecruiymegt, and depending on the chemokjne gradifnt released at the site of injbry, different DC populations will be reccuited. It is expected jhat the type of resukuing immune rxsponsq will linely be dependent on the DC subpopulauion recruited and thus on tha chelokines secreted (Caux, C. et al
el J, Stueckle S, Ross F P, L, L J. J Cell Biochem and are professional antigen-presenting that play key in both innate and adaptive immunity. and macrophages are attracted to infection and inflammatory sites by a variety of among which chemokines constitute the largest group so far (Caux, C. et al. Transplantation S7-S11, I. Steinman, R M (2001) Cell 106:255-258). It has been shown that tremendous functional, morphological and metabolic exists among these cell populations. One of these differences is the expression differential sets of chemoattractant receptors, is for the recruitment specific subpopulations, according to lineage, origin and maturation state (Caux, C. et al. (2002) Transplantation 73: S7-S11). Many tumor types have demonstrated to and DCs the or production of chemoattractant L M and Werb, Z. (2002) A P and Caux, C. (2002) Cytokine Growth Rev. 13:143-154). include a number of CC-chemokines, such MCP-1. DCs are specialized antigen-presenting cells located throughout human body. DCs function as sentinels of the immune system. They serve as essential link and adaptive immune systems induce both primary secondary responses K and Banchereau, (1999) J. Clin. Immunol. 19:12-25). They traffic from the blood to tissues where, while immature, they capture antigens. They then leave and to the draining organs where, coverted into DCs, initiate the immune response naïve cells, and the tumor cells. Chemokines are effectors of the regulation of recruitment, and depending on the site of injury, different DC populations will recruited. It is expected that the type resulting immune response will likely be dependent on the DC subpopulation recruited thus on secreted (Caux, C. et al
el J, Stueckle S, Ross F P, TeitelbAum S L, Suva L j. (1999) J CelL BiOchEm 74: 587-95).
dendRitiC cells (DCs) and maCRophAges are professional antIgen-pReSEntiNG cElls tHat play KEy ROLes In BoTh iNnATe And adAptIve immuNity. DCs and MacRoPhages are attRAcTed to infecTioN and inflammaTorY sites By A vaRIety oF faCtors, Among wHIch cheMokines coNsTItute tHE largesT GRoUp so Far (Caux, C. et al. (2002) TransPLaNTation 73: S7-S11, MellmaN, I. and STeINmAN, r M (2001) CEll 106:255-258). it has been sHoWn thaT TremendOUs FUNCtiONal, morphologiCal and metabOLic DiversItY exISts amoNg theSe CEll Populations. one oF these funCtionaL DiffereNCes is thE expreSsiOn oF difFErEnTiaL sETs oF ChEmoATtrActant reCePtOrs, whIch iS RESPonsIblE for The seLective recruiTmeNt of SPecIfic cEll suBpopUlAtionS, accorDing tO tHeir lineage, origIn anD maturatiOn sTaTe (CAuX, C. et aL. (2002) transpLanTatIon 73: S7-S11). MaNy tumor TYpeS hAVE BeEn demonstrated to atTrACT mAcrophagEs and DcS tHrOUgh the diReCt oR indIREct prOducTIoN of chemoAttracTAnT fActors (COuSsens, L m aNd WErb, z. (2002) NatuRE 420:860-867, VicAri, A P aNd Caux, C. (2002) CYtokiNE Growth Factors rEv. 13:143-154). These includE A nUMBeR Of CC-CheMokines, such As MCp-1.
dCs aRe spECiAliZEd antIgen-pReSEnTIng cells located throUgHout thE humaN body. DCs functIon as sentiNELS of the imMune SYsTEm. They serve as eSsentIal link betWEen innatE and aDaptive iMmune systEMS and induCe bOth PriMarY ANd Secondary immuNE RespOnSes (PaluCka, k A and BaNchEreAu, J. (1999) j. ClIn. immunol. 19:12-25). ThEy traffiC fRoM tHe BloOd to tHE tissues WhEre, WhIle ImmatURe, they CaptuRe anTiGeNS. ThEy then lEAvE THe tiSsUeS and MovE tO the dRainINg lYmphoid Organs wheRe, cOVertEd InTo maturE DCs, they initiAtE the immune ReSpoNse by aCTIvating nAïve CD8+ cells, which seek out ANd kill tHe aNtigeN-expRessing tuMor Cells. CHemOKines aRe impoRtant EfFecTORs of tHE ReGulAtIon of DCs reCRUitMent, aNd DepeNding on The chemokine gradieNT reLeased at the siTe oF injURY, dIffEReNT DC PoPUlaTIOns will be recruiTed. It is expEcTEd That the typE Of rEsUlting iMmune reSponsE Will likEly be depeNdent on thE Dc subPOPulAtion recruIted and tHus on the cHEmokiNEs SecreTed (caux, C. eT aL
el J, Stueckle S, Ross F P , Teitelba um SL,Suv aL J.  (19 99) J Cell Bio c hem74: 587-95).
Dendritic  cell s( DCs) an d mac rophage s  a r e  pr of es sio na l  a ntige n-p resenti ng cells t hat  p lay key role s  i n both inn ate  and adaptiv e i mmunit y.  DC s  andmac ropha ges ar e  attra cted to i nf e ctiona nd infl a m ma tory  sites by a varie t yo f factors, amo ng whi ch ch e m oki nes  constitut ethe l a rgest g r ou p s o f a r (Caux, C. e t al. (2002 )  Tr anspla nt ati o n 73:S7-S1 1, Mel lman, I. an d St einman, R  M (20 0 1) Cell 106:255 -258).  It  ha s be e nsh own  t h att re men d ous  functio na l,  morp holo g i c a l an d m etab olicdiversity exi sts  amo n g t hesecellpopu la tions . Oneof th es e functional di ffer ences isthe  e xpr es siono f diff ere nti al sets  of che m oat tr a c t an t receptors, which  i s re sponsibl e fort he  s e lectivere cru itme n t  of s peci f ic  cell su bpopul a ti on s, acco rd ing to  t hei r l ineag e , or igin a nd matur ation state (Caux, C .  et al. (2002 )  T r a ns p lant ati on 73: S7-S 11). Many  tum o rtyp e s hav e bee nd em o nstrated to attract  m acroph agesand DCs throu gh the dir e c t  or indi rect pr o duction of che moatt ractant fa c tors (Co ussen s, L M a nd Werb,Z .  (2002)Nat ure  42 0:8 6 0 -8 67, Vicari, A P  and  C aux, C.  (2 002) Cy tok ine  Gr owt hFactors R ev. 13:1 43 -1 54 ).  Th ese i n clude anu mbe rofCC-ch e mokine s, su ch a sMC P -1. 
DCs ar e  s p e cial iz ed  ant ige n- prese ntin g  ce lls loc ated thro ugh o ut t he  h uman bo dy. DCs funct io n as senti ne lsof the i mmune sy stem. They serve as ess e ntial l ink  betw eeninnate an d a daptiv e i m mune s ystems  andin duc e bothp r im ary  a nd seconda r y  im munere spon ses (Pa lucka, K A and Ban c her eau, J. (1999 ) J . Cl i n .Imm u no l . 1 9: 1 2-2 5 ) . They trafficfrom the b lo o dto the tis s ues  w here, w hile im matur e , theycapture a ntigens.Th ey t h e n l eave the t issues a nd move t o  thed ra ining  ly mphoid  o rga ns wh ere, c o ver ted i nto ma tu re DCs , the yinitiate  the immune response by  activ ating  na ïve CD8+cel l s,which see k ou t and kill  th e a ntige n-e x press ingt um orc ells.  Che m okines ar e  i mpo r t an t effectors o f  th e reg ula t ion of  DCs  recruitment, and depending on t he c h e mok ine grad ie nt released at  th es i te of in ju ry, differe nt DC po pu l ation s will  be re cruited . It is exp ecte d t hat the t ype  o f  result in gi mmuneresp on se wil l like l y be d ependent on theDC su b p opula t ion  recr ui ted and thus  on the ch emokines se creted  (Ca ux, C . et al 
el J,_Stueckle S,_Ross F P, Teitelbaum_S L,_Suva_L J._(1999)_J Cell Biochem_74: 587-95).
Dendritic cells_(DCs) and macrophages are_professional antigen-presenting cells_that_play key roles in both innate and adaptive immunity. DCs and macrophages are attracted_to_infection and_inflammatory_sites_by a variety of factors,_among which chemokines constitute the_largest group_so far (Caux, C. et al. (2002) Transplantation_73:_S7-S11, Mellman, I._and Steinman, R M (2001) Cell 106:255-258). It has_been shown that tremendous functional, morphological_and metabolic diversity_exists_among_these cell populations. One_of these functional differences is the_expression of differential sets of chemoattractant_receptors, which is responsible for the selective_recruitment of specific cell subpopulations, according_to their lineage, origin and_maturation state_(Caux, C. et al. (2002)_Transplantation 73: S7-S11)._Many tumor_types have been_demonstrated to attract macrophages and DCs_through the direct_or indirect production of chemoattractant factors_(Coussens,_L M and_Werb,_Z._(2002) Nature_420:860-867, Vicari, A_P_and Caux,_C._(2002) Cytokine Growth Factors Rev. 13:143-154)._These_include a number of CC-chemokines, such as_MCP-1.
DCs are specialized antigen-presenting_cells_located throughout the human_body. DCs function as sentinels_of the immune system. They serve_as essential_link between_innate and adaptive immune systems and induce both primary and secondary_immune responses (Palucka, K A and_Banchereau, J. (1999) J._Clin. Immunol._19:12-25)._They traffic from_the_blood to_the tissues where, while immature, they capture_antigens. They_then leave the tissues and move_to the draining lymphoid_organs_where, coverted into mature DCs, they_initiate the immune response by activating_naïve CD8+ cells, which seek_out_and_kill the antigen-expressing tumor cells._Chemokines are important effectors of the_regulation of DCs_recruitment, and depending on the chemokine gradient_released_at the site of injury, different_DC_populations will be recruited. It is_expected_that_the type of resulting immune_response will likely be dependent on_the DC subpopulation recruited and thus on the chemokines_secreted (Caux, C._et al