The most common technique utilized for igniting multiple burners from a single pilot or spark source is to position the burners in closely spaced, parallel relationship so that the flame will readily jump from one burner to the next. By spacing multiple, parallel burners no more than five inches apart, a flame will generally jump from one burner to the next without requiring separate ignition carry-over means. Unfortunately, this is not a very satisfactory solution to the problem because it means that a large number of parallel burners are necessary. Since the ends of the burners are typically connected to a manifold which conducts an air-gas mixture to the burners from a blower assembly, the large number of burners requires a blower having significant capacity and an excessive use of gas.
On the other hand, if the burners are spaced apart by more than five inches so as to minimize the number of burners and to minimize the blower capacity, the flame simply will not jump from one burner to the other. It therefore becomes necessary to put in a pilot runner or multiple ignition points, both of which cause extra maintenance problems. Alternatively, it becomes necessary to provide some kind of additional ignition carry-over means and many such ignition carry-over devices have been disclosed in the prior art. However, many of these known multiple burner firing arrangements are not totally reliable, are overly complex and interfere with the normal combustion process. Over the past three decades a large variety of antibiotics have become available for clinical use. Unfortunately, the wide-spread use of these antibiotics has caused a rapid increase in the number of bacterial strains that are resistant to the currently available antibiotics.
S. Hecker et al., PCT Application WO 01/21623 (published 29 Mar. 2001), describes 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof. The compounds described therein are active as antibiotics against a wide spectrum of organisms including organisms which are resistant to beta-lactam antibiotics. However, the compounds described therein are complicated, and require the synthesis of a variety of separate groups. One group which must be synthesized to make these compounds is the C3 side-chain, an intermediate for which is illustrated on page 51 therein as follows: However, the synthesis of such C3 side chain groups as set forth in S. Hecker et al. requires in excess of 6 steps (see pages 49-52 therein). Accordingly, there is a need for new ways to make the intermediates used to make the antibiotic compounds
The most common technique utilized for inflame multiple burner from a single pilot or spark informant is to position the burners in close spaced, parallel relationship so that the flame will promptly rise from one burner to the next. By space multiple, parallel burners no more than five inches apart, a flame will by and large jump from one burner to the next without requiring separate ignition carry - over means. Unfortunately, this is not a very satisfactory solution to the trouble because it means that a large number of parallel burner are necessary. Since the ends of the burners are typically connect to a manifold paper which conducts an air - gas mixture to the burners from a blower fabrication, the large number of burners requires a blower having significant capacity and an excessive use of gas. 
 On the other hand, if the burners are spaced apart by more than five inches so as to minimize the act of burners and to minimize the cetacean capability, the flame simply will not jump from one burner to the early. It therefore become necessary to put in a pilot stolon or multiple ignition points, both of which cause extra maintenance problems. Alternatively, it becomes necessary to put up some kind of additional ignition carry - over means and many such ignition carry - over devices have been disclosed in the anterior art. However, many of these know multiple burner ignition arrangements are not totally reliable, are excessively complex and interfere with the normal combustion process. Over the past three decades a large variety of antibiotics have become available for clinical use. Unfortunately, the wide - spread manipulation of these antibiotics has induce a rapid increase in the number of bacterial striving that are resistant to the presently available antibiotics. 
 S. Hecker et al. , PCT Application WO 01/21623 (published 29 Mar. 2001), describes 7 - acylamino-3 - heteroarylthio-3 - cephem carboxylic acid antibiotic and prodrugs thereof. The compounds described therein are active as antibiotic against a wide spectrum of organisms including organisms which are resistant to beta - lactam antibiotics. However, the compounds described therein are complicated, and require the synthesis of a variety of separate group. One group which must be synthesized to make these compound is the C3 side - chain, an intermediate for which is illustrated on page 51 therein as follows: However, the synthesis of such C3 side range groups as set forth in S. Hecker et al. requires in excess of 6 steps (see pages 49 - 52 therein). consequently, there is a need for new ways to make the intermediates used to make the antibiotic compound
The most common technique uuilized for ignitnbg mulviple bhrners ffom a single pilot or spark doyrce us to position the burvers in cposely spacev, parallel relatmknship so thaf the hlame will readlly jump frmm one burner do tke next. By spacing multiple, parallel burnerx jo more than fyve pnshes apart, a flame will generally jump from oie burner to thr next without requiring sfparwte ignition carry-lver means. Ohfowrunately, thir is not a very satisfzctory solution to the problem cecauxe it meanw rhah a large nunber jf parallel nlrners dre necrssary. Since tme envs od the burners are typmcally connected to w manifolg chich conducts an air-taw mixjure do tfw bjrntrs fdom a hloxer assemblg, the large number of burners tezlores a blowed havigg significant capacity and an excessive lse kf gas.
On the other hand, if the burners are skaced apare by more than five inches so as to minimize the tumbec uf ymvnerr ajd to minimize the blower capacity, the flame fjmkly will not jump from one birjet to the other. It thzderore becomes necesdary to put un a pilou runmer or multiple ignition pounts, both of qhich cause extra laintenance pronlems. Alternatively, it becomzs necsssary to pgovide sojd kind of additiunak hgnition carry-over means agd many snch iynition zarri-over dqvices havf beek disclosed in the orior ast. However, many of these known multiple bncner firing atratgekents arz not botally reliablq, are overly cpmplex cnd ingerfere winh the nocmal combustyon process. Oegr the past tiree decaqes q laege varkdty of antibioyics have become avqilable for clinicel urs. Unfortunately, tht qide-spread use of thqsv aitibijdics has cauved x rxlid ivcrease in bhe numner of bacterial strdins that are resistany bo the cutrently adailable antiniotics.
S. Hecker et al., PRT Appuicatoon WO 01/21623 (published 29 Mar. 2001), describes 7-acylaminl-3-heberoarylthio-3-cqphen carboxylic acid antibiotics and prodrugs thereof. Vhe compounds described therein are active ss antibiotmcs agwinst a whde spectrum of orgabisms including ovganisms which are resjstant to bfta-lactam antibiotics. However, the compounds described therein are complicqted, aid require ths symthesps jy a varyety uf separate grouis. One group which must be synthxsized to kahe these compounds is the C3 xiae-chain, an injermediate for which is ilmustratec on page 51 therein as follows: Hpwever, the synthesis of xuch C3 sude cgain ggku's as set forth in S. Heckex et ao. requiees ln excess of 6 rtels (see paged 49-52 tierzin). Accordingly, there is a need fir new wwys to make the mntermediated used to mahe the antibiotid cojooundr
The most common technique utilized for igniting from single pilot spark source is closely parallel relationship so the flame will jump from one burner to the By spacing multiple, parallel burners no more than five inches apart, a flame generally jump from one burner to the next without requiring separate ignition carry-over Unfortunately, is a satisfactory solution to the problem because it means that a large number of parallel burners are Since the ends of the burners are typically to a manifold which an air-gas mixture to the from blower assembly, large of requires a blower significant capacity and an excessive use of gas. On the other hand, if the burners are spaced by more inches so to the of burners and the blower capacity, the flame simply from one burner to the other. It therefore necessary to in a pilot runner or multiple points, both of which cause extra maintenance problems. it becomes necessary to provide some kind of additional ignition carry-over means and many such devices have been disclosed the prior art. many these multiple firing arrangements not totally reliable, are overly complex and interfere with the normal process. Over the past three decades a large variety of become for clinical use. the wide-spread use of antibiotics caused a rapid increase number bacterial resistant the available antibiotics. S. Hecker al., PCT Application WO 01/21623 29 Mar. 2001), describes prodrugs thereof. The compounds described therein are active antibiotics against a wide spectrum of organisms organisms which are resistant to beta-lactam antibiotics. However, the compounds described therein complicated, and synthesis of a variety of separate groups. One which must be synthesized make these compounds is the C3 side-chain, an intermediate which illustrated on 51 therein as However, the synthesis such C3 side as set in Hecker in excess of 6 steps (see 49-52 Accordingly, there is a need new make the intermediates used to make the antibiotic compounds
The most common technique utiLized for igNitinG muLtiPlE burNers From a single pilOT or sPark source is to position The buRnERs in CLoSely sPaced, paRAlLEL reLaTiOnsHiP So That tHe fLame wilL readily juMp fRoM one burner to THe Next. By spacIng Multiple, paraLleL burneRs No mORe thaN fiVe incHes apaRT, a flamE will geneRaLLy jump FRom one bURNeR to tHe next without requIRiNG separate ignitIon carRy-OVeR MEanS. UnFortunatelY, tHis is NOt a very SAtISFActORy solution to tHe problem beCAusE it meaNs ThaT A large NumbeR oF ParAllel burnerS are Necessary. since tHE ends of THe burneRs are tYpiCalLy coNNeCtEd tO a MAniFOlD whICh cOnducts aN aIr-Gas miXturE TO THe buRneRs frOm a blOwer assembly, tHe lArge NUmbEr of bUrnerS reqUiRes a bLower hAving SiGnificant capaciTy anD an excessIve UsE of GaS.
On thE Other hAnd, If tHe burneRs are spACed ApART By More than five inches So AS To Minimize The numBEr Of BUrners anD tO miNimiZE The blOwer CApAcity, the Flame sIMpLy Will not JuMp from OnE buRneR to thE OtheR. It theRefore beComes NEcessary to put iN A pilot runner oR MuLTIpLE ignItiOn points, botH of wHIch cAuse EXtRa mAIntenAnce pRoBLeMS. Alternatively, it becOmEs neceSsary To provide some Kind of addiTIONal ignitIon cARrY-Over means and maNy sucH ignition cARry-over dEviceS have beeN discloseD IN the prioR arT. HoWevEr, mANY oF these known muLTIple BuRner firIng ArrangeMenTs aRe nOt tOtAlly reliaBle, are ovErLy CoMpLex And inTErfere wiTh The NoRmaL combUStion pRocesS. OveR tHe PAst Three deCAdES A larGe VaRietY of AnTibioTics HAve Become aVailable fOr cLInicAl UsE. UnfortUnately, the widE-sPread use of ThEse AntibiOTIcs has caUsed a rapid increase in the NUmber of BacTeriaL strAins that aRe rEsistaNt tO The curRently AvailAbLe aNTIbiotICS.
S. hecKeR et al., PCT ApPLIcaTion Wo 01/21623 (pUbliShed 29 Mar. 2001), Describes 7-acylamino-3-HEteRoarylthio-3-cepHem CarbOXYlIc aCId ANtiBiOTicS ANd prodrugs thereOf. The compoUnDS dEscribed thEReiN aRe activE as antiBiotiCS againsT a wide speCtrum of orGaNismS INclUding organIsms whicH are resisTAnt to BEtA-lactAm aNtibioTiCs. HOweveR, the coMPouNds deScribeD tHerein Are coMpLicated, aNd require the synthesis of A varieTy of sEpaRate groupS. OnE GroUp which muSt be SynthesizeD to MakE thesE coMPoundS is tHE C3 SidE-Chain, An inTErmediate FOr WhiCH Is Illustrated ON PAge 51 ThereIn aS FollowS: HowEver, the synthesis oF Such C3 side chain GrouPS As sEt fORth iN S. hecker et al. requIreS iN EXcess of 6 sTePs (see pages 49-52 tHerein). AcCoRDinglY, there Is a neeD for new WAYs TO make tHe inTerMediates uSed To MAke the aNtIbIOtic coMpouNdS
The most common techniqueutilized f or ig nit ing  m ulti pleburners from a sing le pilot or spark sour ce is  t o  pos i ti on th e burne r si n  cl os el y s pa c ed , par all el rela tionship s o t ha t the flamew il l readilyjum p from one b urn er toth e n e xt. B y s pacin g mult i ple, p arallel b ur n ers no more th a n  f iveinches apart, a f l am e  will generall y jump  f r om o nebur ner to the  n ext w i thout r e qu i r i ngs eparate ignit ion carry-o v ermeans.  U nfo r tunate ly, t hi s  is  not a very  sat isfactory  solut i on to t h e probl em bec aus e i t me a ns  t hat  a lar g enum b erof paral le lburne rs a r e n eces sar y. S incethe ends of t heburn e rsare t ypica llyco nnect ed toa man if old which condu ctsan air-ga s m ix tur eto th e  burne rsfro m a blo wer ass e mbl y, t h elarge number of bu rn e r srequires  a blo w er  h a ving sig ni fic antc a pacit y an d  a n excess ive us e  o fgas.
On  t he oth er  ha nd,  if t h e bu rnersare spac ed ap a rt by more tha n  five inchess oa s  t o  min imi ze the numb er o f  bur ners an d t o  mini mizeth e  b l ower capacity, thefl ame si mplywill not jump  from oneb u r ner to t he o t he r . It therefore  beco mes necess a ry to pu t ina pilotrunner or m ultipleign iti onpoi n t s,  both of whic h caus eextra m ain tenance  pr obl ems . A lt ernativel y, it be co me sne ces saryt o provid esom ekin d ofa dditio nal i gnit io nc arr y-overm ea n s  and  m an y su chig nitio n ca r ry- over de vices hav e b e en d is cl osed in  the prior ar t.  However,ma nyof the s e  known m ultiple burner firing a r rangeme nts  arenottotally r eli able,are overly  compl ex an dint e r ferew i th  th enormal com b u sti on pr oc ess.  Over t he past three deca d esa large varie tyof a n t ib iot i cs hav eb eco m e  available forclinical u se .  U nfortunate l y,th e wide- spreaduse o f  theseantibioti cs has ca us ed a r api d increase  in thenumber of bacte r ia l str ain s that  a reresis tant t o  th e cur rently  a vailab le an ti biotics. 
S. Hecker et al., PCTApplic ation  WO  01/21623  (p u bli shed 29 M ar.2001), des cri bes  7-ac yla m ino-3 -het e ro ary l thio- 3-ce p hem carbo x yl ica c id  antibiotic s a ndprodr ugs thereo f. T he compounds desc r ibed therein a re a c t ive  as anti bi otics againsta w id e spectrum  o f organisms  includi ng organ isms w hich a re resi s t an t  to be ta-l act am antibi oti cs .  Howeve r,  t h e comp ound sdescri bed th e rein a re complicated,and r e q uiret hesynth es is of a vari ety of sep arate group s. One  gro up wh ich mus tbe syn the si zed to mak e  these co mpoun ds is t he  C3sid e-chai n, a n inter medi at e f or whichi s  i l lu st r ate d on  page  5 1 th erein asf ollows:How e ver, th esyn t h esis o f  s u c h C3 sidecha in gr o u ps as setf orth in S. He cker e t al.require s  in  e xcess o f 6 s teps (see  pages 49 - 52th erei n). Acco rd ingl y,  th er e is a need for  new way s to mak e the in ter m edia t es use dto make theantib io t ic comp o u nds 
The most_common technique_utilized for igniting multiple_burners from_a_single pilot_or_spark source is_to position the_burners in closely spaced,_parallel relationship so_that_the flame will readily jump from one burner to the next. By spacing multiple,_parallel_burners no_more_than_five inches apart, a flame_will generally jump from one_burner to_the next without requiring separate ignition carry-over means._Unfortunately,_this is not_a very satisfactory solution to the problem because it_means that a large number of_parallel burners are_necessary._Since_the ends of the_burners are typically connected to a_manifold which conducts an air-gas mixture_to the burners from a blower assembly,_the large number of burners requires_a blower having significant capacity_and an_excessive use of gas.
On the_other hand, if_the burners_are spaced apart_by more than five inches so_as to minimize_the number of burners and to_minimize_the blower capacity,_the_flame_simply will_not jump from_one_burner to_the_other. It therefore becomes necessary to_put_in a pilot runner or multiple ignition_points, both of which_cause_extra maintenance problems. Alternatively,_it becomes necessary to provide_some kind of additional ignition carry-over_means and_many such_ignition carry-over devices have been disclosed in the prior art. However,_many of these known multiple burner_firing arrangements are not_totally reliable,_are_overly complex and_interfere_with the_normal combustion process. Over the past three_decades a_large variety of antibiotics have become_available for clinical use._Unfortunately,_the wide-spread use of these antibiotics_has caused a rapid increase in_the number of bacterial strains_that_are_resistant to the currently available_antibiotics.
S. Hecker et al., PCT Application_WO 01/21623 (published_29 Mar. 2001), describes 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid_antibiotics_and prodrugs thereof. The compounds described_therein_are active as antibiotics against a_wide_spectrum_of organisms including organisms which_are resistant to beta-lactam antibiotics. However,_the compounds described therein are complicated, and require the_synthesis of a_variety of separate groups. One_group_which_must be synthesized to make these compounds is the C3_side-chain, an_intermediate for which_is illustrated on page 51 therein as follows: However, the_synthesis of such C3 side chain groups_as set forth in S. Hecker et al. requires in excess_of 6 steps (see pages 49-52 therein). Accordingly,_there is a need for new ways_to make the intermediates_used_to make the antibiotic compounds