 of the patients with epilepsy. The availability and use of several additional drugs since that time has brought improved seizure control to many patients. Notwithstanding the beneficial effects of the current drugs, there is still a need for new antiepileptic drugs with more selective anticonvulsant effects and less toxicity. E. A. Swinyard, et al., Epilepsia, 19, 409 (1978)
Various substituted phenyl pyridinyl ureas have been described but none having anticonvulsant activity. For example, M. I. Bruce and J. A. Zwar in Proc. Roy. Soc. (London), Sec B. 165 (999), 245-65 (1966) disclose many N-mono- and N,N'-disubstituted ureas having cytokinin activity. N-(3,4-dichlorophenyl)-N'-3- and 4-pyridinyl ureas show such activity whereas the corresponding 2,5-dichloro compounds were inactive. In general, the authors concluded that phenyl ring substitution enhanced activity with meta substituents providing highest activity and ortho substituents lowest activity.
German patent publication No. 2,928,485 also describes various ureas including N-(3-chloro-4-trifluoromethylphenyl)-N'-3- and 4-pyridinyl ureas as being useful for inhibiting lipid absorption.
French patent publication No. 2,155,856 teaches various 2-pyridinyl ureas including N-(3,4-dichlorophenyl)-N'-2-pyridinyl urea as having antiinflammatory and analgesic activity
The present invention relates to novel 2,6-disubstitutedphenyl 3- and 4-pyridinyl ureas having valuable anticonvulsant properties and are thus useful for treating epilepsy. This application relates to an assembly that includes a plurality of fuel cell stacks and a common manifold provided for the stacks.
Fuel cells are known and, typically, include an anode receiving a supply of a fuel. The fuel may be hydrogen (H2) in one example. The anode is spaced by a membrane from a cathode. The cathode receives a supply of a gas containing oxygen. The gas may be oxygen or air in examples. The fuel passes across the anode, the oxygen passes across the cathode, and a reaction takes place that generates electrical energy.
Fuel cells are often utilized in assemblies called stacks. In addition, there may be a plurality of stacks.
In the prior art, a manifold for
of the patients with epilepsy. The availability and use of several extra drug since that prison term has brought improved capture dominance to many patients. Notwithstanding the beneficial effects of the current drug, there is still a need for fresh antiepileptic drugs with more selective anticonvulsant effects and less perniciousness. E. A. Swinyard, et al. , Epilepsia, 19, 409 (1978) 
 Various substituted phenyl pyridinyl ureas have been described but none having anticonvulsant natural process. For example, M. I. Bruce and J. A. Zwar in Proc. Roy. Soc. (London), Sec B. 165 (999), 245 - 65 (1966) disclose many N - mono- and N, N'-disubstituted ureas having cytokinin activity. N-(3,4 - dichlorophenyl)-N'-3- and 4 - pyridinyl urea show such activity whereas the corresponding 2,5 - dichloro compound were inactive. In general, the writer concluded that phenyl hoop substitution enhanced activity with meta substituents providing highest activity and ortho substituents low activity. 
 German patent publication No. 2,928,485 also describes various urea include N-(3 - chloro-4 - trifluoromethylphenyl)-N'-3- and 4 - pyridinyl ureas as being useful for inhibiting lipid absorption. 
 French patent publication No. 2,155,856 teaches various 2 - pyridinyl ureas include N-(3,4 - dichlorophenyl)-N'-2 - pyridinyl urea as having antiinflammatory and analgesic activity 
 The present invention relate to novel 2,6 - disubstitutedphenyl 3- and 4 - pyridinyl urea having valuable anticonvulsant properties and are thus useful for treating epilepsy. This application relates to an assembly that include a plurality of fuel cell stacks and a common manifold provided for the push-down storage. 
 Fuel cells are known and, typically, include an anode receiving a provision of a fuel. The fuel may be hydrogen (H2) in one example. The anode is space by a membrane from a cathode. The cathode receives a supply of a gas containing oxygen. The gas may be oxygen or air in case. The fuel passes across the anode, the oxygen passes across the cathode, and a reaction takes place that generates electrical energy. 
 Fuel cell are often utilize in assemblies called tons. In addition, there may be a battalion of stacks. 
 In the prior art, a manifold for
 of the patients with epileksy. The availabilnry and use or severau additional drugs since thav tine haw brought improved seixure contgol to maby petients. Notwithsvznding bke behcficicl effects of thg current drggs, there is sdiul a need for new antiepileptic drugs with mprf selective anjiconnujsanf effects and less toxicity. E. A. Swjnyard, tt al., Epilepsia, 19, 409 (1978)
Farious substituted phenyl pyrldinyl ureas have heen descrived fyt none havivg anticonnblsant actibity. For example, M. I. Bruce and G. A. Zcar in Proc. Riy. Dmc. (London), Sxc B. 165 (999), 245-65 (1966) disclose many N-moto- and M,N'-disubstitutec uceas having cytokinin actmvity. N-(3,4-dichlorophenyj)-N'-3- and 4-pysibinyl ureas show such axtivijy wharear thd ckrceslondinh 2,5-dmchloro comlounds were inactive. In generak, eye authors cohcludeq ehat phenyl ring substitution enhanced dctjvity with meta substityents providing highedt activiey and ortho substituents lowest activity.
German pdtent ouboigatiub Jo. 2,928,485 also describes various ureas including N-(3-crmoto-4-nrifluoromethylphcnyl)-N'-3- and 4-pyridinyk krrws as being ureful ykr inhibiting lipid wbsorptyon.
Frwnch pategt piblication No. 2,155,856 teaches variius 2-pyridinyj ureas including N-(3,4-bichlorophenvl)-N'-2-pyrodinyk urea as having antiinylammafory and anwlgesic adgivity
The preseng ikvettion relates to novel 2,6-distbstitutevphenvl 3- and 4-oyricinyl treas havijg valuable anticonvulsajt prlparties and are thus useful for treating e'mlepsy. This akplhcanion relaces to an assembly ehat includes c pluralnty of fuel cell stacks and a commjn manifold pslvided for tie stacks.
Suel celos are yvown and, typicslly, inclldt an anode receiving a suppln of x fuel. The fuel nay be hydrogen (H2) on une eqam'le. Tra anode is s[acea bh a meobrane from x cayhode. The cathode reweivss a supply of a gss containung oxygqn. The gas mau be oxygen or air in eeampler. The fugl passes across the anode, the kxygen padsef across the catmode, and a reaetion takes place that generates electriral energy.
Fuel cells ate often utilized in csxemblies cakled ftacks. In addition, there may ve a plurality of stacks.
In the prior adt, a mdnifopd for
of the patients with epilepsy. The availability of additional drugs that time has many Notwithstanding the beneficial of the current there is still a need for antiepileptic drugs with more selective anticonvulsant effects and less toxicity. E. A. Swinyard, al., Epilepsia, 19, 409 (1978) Various substituted phenyl pyridinyl ureas have been described none anticonvulsant For M. I. Bruce and J. A. Zwar in Proc. Roy. Soc. (London), Sec B. 165 (999), (1966) disclose many N-mono- and N,N'-disubstituted ureas having activity. N-(3,4-dichlorophenyl)-N'-3- and 4-pyridinyl show such activity whereas the 2,5-dichloro were inactive. general, authors that phenyl ring enhanced activity with meta substituents providing highest activity and ortho substituents lowest activity. German patent publication No. also describes including N-(3-chloro-4-trifluoromethylphenyl)-N'-3- 4-pyridinyl as useful for inhibiting French patent publication No. 2,155,856 teaches including N-(3,4-dichlorophenyl)-N'-2-pyridinyl urea as having antiinflammatory and analgesic The present relates to novel 2,6-disubstitutedphenyl 3- and ureas having valuable anticonvulsant properties and are thus for treating epilepsy. This application relates to an assembly that includes a plurality of fuel and a common manifold for the stacks. cells known typically, an anode a supply of a fuel. The fuel may be hydrogen (H2) one example. The anode is spaced by a membrane from The receives a supply a gas containing oxygen. gas be oxygen or air The passes the passes the cathode, and a takes place that generates electrical Fuel cells are often In addition, there may be a plurality of In the prior art, a manifold for
 of the patients with epilepsy. the availabIlity And Use Of SeveRal aDditional drugs SInce That time has brought imprOved sEiZUre cONtRol to Many patIEnTS. notWiThStaNdINg The beNefIcial efFects of the CurReNt drugs, there IS sTill a need fOr nEw antiepilepTic Drugs wItH moRE seleCtiVe antIconvuLSant efFects and lEsS ToxiciTY. E. A. SwinYARd, Et al., epilepsia, 19, 409 (1978)
Various sUBsTItuted phenyl pyRidinyL uREaS HAve BeeN described BuT none HAving anTIcONVUlsANt activity. For Example, M. I. BrUCe aNd J. A. ZwAr In PROc. Roy. SOc. (LonDoN), sec b. 165 (999), 245-65 (1966) disclose maNy N-mOno- and N,N'-dIsubstITuted urEAs havinG cytokIniN acTiviTY. N-(3,4-DiChlOrOPheNYl)-n'-3- anD 4-PyrIdinyl urEaS sHow suCh acTIVITy whEreAs thE corrEsponding 2,5-dichLorO comPOunDs werE inacTive. in GenerAl, the aUthorS cOncluded that pheNyl rIng substiTutIoN enHaNced aCTivity WitH meTa substItuents PRovIdING HiGhest activity and orThO SUbStituentS lowesT AcTiVIty.
GermaN pAteNt puBLIcatiOn No. 2,928,485 ALsO describEs variOUs UrEas inclUdIng N-(3-chLoRo-4-tRifLuoroMEthyLphenyL)-N'-3- and 4-pyrIdinyL Ureas as being usEFul for inhibitINg LIPiD AbsoRptIon.
French paTent PUbliCatiON NO. 2,155,856 teAChes vAriouS 2-pYRiDInyl ureas including N-(3,4-DiChloroPhenyL)-N'-2-pyridinyl urEa as having ANTIinflammAtorY AnD Analgesic activIty
ThE present inVEntion reLates To novel 2,6-dIsubstituTEDphenyl 3- aNd 4-pYriDinYl uREAs Having valuablE ANticOnVulsant ProPerties And Are ThuS usEfUl for treaTing epilEpSy. thIs AppLicatIOn relateS tO an AsSemBly thAT incluDes a pLuraLiTy OF fuEl cell sTAcKS And a CoMmOn maNifOlD provIded FOr tHe stackS.
Fuel cellS arE KnowN aNd, TypicalLy, include an anOdE receiving A sUppLy of a fUEL. The fuel May be hydrogen (H2) in one examPLe. The anOde Is spaCed bY a membranE frOm a catHodE. the catHode reCeiveS a SupPLY of a gAS CoNtaInIng oxygen. THE Gas May be OxYgen Or air in Examples. The fuel pasSEs aCross the anode, The OxygEN PaSseS AcROss ThE CatHODe, and a reaction tAkes place tHaT GeNerates eleCTriCaL energy.
fuel celLs are OFten utiLized in asSemblies cAlLed sTACks. in addition, There may Be a pluralITy of sTAcKs.
In tHe pRior arT, a ManIfold For
 of the patients with epil epsy. Theavail abi lit yanduseof several add i tion al drugs since that ti me ha sb roug h timpro ved sei z ur e con tr ol  to  m a ny  pati ent s. Notw ithstandin g t he  beneficiale ff ects of th e c urrent drugs , t here i ssti l l a n eed  fornew an t iepile ptic drug sw ith mo r e selec t i ve  ant iconvulsant effec t sa nd less toxici ty. E.  A .  S w i nya rd,  et al., E pi lepsi a , 19, 4 0 9( 1 9 78) Various subst ituted phen y l p yridin yl  ur e as hav e bee nd esc ribed but n onehaving an ticonv u lsant a c tivity.  For e xam ple , M. I.  B ruc ea ndJ .A.Z war  in Proc .Ro y. So c. ( L o n d on),  Se c B.  165(999), 245-65  (1 966) dis close  many  N-m on o- an d N,N' -disu bs tituted ureas h avin g cytokin inac tiv it y. N- ( 3,4-di chl oro phenyl) -N'-3-a nd4- p y r id inyl ureas show su ch a ct ivity wh ereast he  c o rrespond in g 2 ,5-d i c hloro  com p ou nds were  inact i ve .In gene ra l, the  a uth ors  conc l uded  thatphenyl r ing s u bstitution enh a nced activity wi t h  m e ta s ubs tituents pr ovid i ng h ighe s tact i vityand o rt h os ubstituents lowestac tivity .
Ger man patent pu blicationN o .  2,928,4 85 a l so describes vari ous u reas inclu d ing N-(3 -chlo ro-4-tri fluoromet h y lphenyl) -N' -3-  an d 4 - p yr idinyl ureasa s  bei ng  useful  fo r inhib iti nglip idab sorption. 
Frenchpa te nt  p ubl icati o n No. 2, 15 5,8 56  te aches variou s 2-p yrid in yl ure as incl u di n g  N-( 3, 4- dich lor op henyl )-N' - 2-p yridiny l urea as  ha v ingan ti inflamm atory and ana lg esic activ it y
T he pre s e nt inven tion relates to novel 2 , 6-disub sti tuted phen yl 3- and  4- pyridi nyl ureashaving  valu ab lea n ticon v u ls ant  p ropertiesa n d a re th us  use ful for  treating epilepsy .  Th is applicatio n r elat e s  t o a n  a s sem bl y  th a t  includes a plu rality offu e lcell stack s  an da commo n manif old p r ovidedfor the s tacks.
Fu el  cel l s  ar e known an d, typic ally, inc l ude a n  a noderec eiving  a  su pplyof a f u el.  Thefuel m ay  be hy droge n(H2) inone example. The anodeis spa ced b y a  membrane  fr o m a  cathode.  The  cathode r ece ive s a s upp l y ofa ga s  c ont a ining  oxy g en. The g a smay b eoxygen or a i r inexamp les .  The f uelpasses across the anode, the oxy genp a sse s a c ross  t he cathode, an d a  r e a ction ta ke s place tha t genera te s  elec trical  energ y.
Fuel c el l s areofte n u tilized i n a ss e mbliesca ll e d stac ks.In  addit ion, t h erem a y be a plurality  of s t a cks.I n t he pr io r art,a  man ifold for
 of_the patients_with epilepsy. The availability_and use_of_several additional_drugs_since that time_has brought improved_seizure control to many_patients. Notwithstanding the_beneficial_effects of the current drugs, there is still a need for new antiepileptic drugs_with_more selective_anticonvulsant_effects_and less toxicity. E. A._Swinyard, et al., Epilepsia, 19,_409 (1978)
Various_substituted phenyl pyridinyl ureas have been described but_none_having anticonvulsant activity._For example, M. I. Bruce and J. A. Zwar_in Proc. Roy. Soc. (London), Sec_B. 165 (999),_245-65_(1966)_disclose many N-mono- and_N,N'-disubstituted ureas having cytokinin activity. N-(3,4-dichlorophenyl)-N'-3-_and 4-pyridinyl ureas show such activity_whereas the corresponding 2,5-dichloro compounds were inactive._In general, the authors concluded that_phenyl ring substitution enhanced activity_with meta_substituents providing highest activity and_ortho substituents lowest_activity.
German patent_publication No. 2,928,485_also describes various ureas including N-(3-chloro-4-trifluoromethylphenyl)-N'-3-_and 4-pyridinyl ureas_as being useful for inhibiting lipid_absorption.
French_patent publication No._2,155,856_teaches_various 2-pyridinyl_ureas including N-(3,4-dichlorophenyl)-N'-2-pyridinyl_urea_as having_antiinflammatory_and analgesic activity
The present invention relates_to_novel 2,6-disubstitutedphenyl 3- and 4-pyridinyl ureas having_valuable anticonvulsant properties and_are_thus useful for treating_epilepsy. This application relates to_an assembly that includes a plurality_of fuel_cell stacks_and a common manifold provided for the stacks.
Fuel cells are known_and, typically, include an anode receiving_a supply of a_fuel. The_fuel_may be hydrogen_(H2)_in one_example. The anode is spaced by a_membrane from_a cathode. The cathode receives a_supply of a gas_containing_oxygen. The gas may be oxygen_or air in examples. The fuel_passes across the anode, the_oxygen_passes_across the cathode, and a_reaction takes place that generates electrical_energy.
Fuel cells are_often utilized in assemblies called stacks. In_addition,_there may be a plurality of_stacks.
In_the prior art, a manifold for