 inconvenient. The new bisphosphonates such as alendronate have had encouraging results with an increase in bone density and decrease in fractures with few side effects. Current research for new compounds has concentrated on the systemic administration of bone anabolic compounds such as parathyroid hormone (PTH) or fragments of PTH or locally acting cytokines or bone growth factors such as bone morphogenic proteins. The appeal of PTH is that there are specific PTH receptors in bone.sup.(2) and it is well established in both experimental animal.sup.(3) and patient studies that intermittent doses of injected PTH is the most effective agent known to increase bone formation and bone strength.sup.(4-6). This effect is additive to that of estrogens. The problem with the administration of PTH is that it is a peptide and must therefore be given by injection. Women with osteoporosis have intact but inadequately functioning parathyroids and an alternative approach is to stimulate their own parathyroids to synthesize and secrete more PTH. It has been evidenced in experimental animals that this is eminently practicable and this is the basis of this present patent application.
Postmenopausal osteoporotic women do not have the appropriate increase in nocturnal serum PTH levels. In osteoporotic women, careful and repeated measurements of serum PTH, and analysis by time series prediction of plasma hormone concentration has shown that there are differences in the predictability of parathyroid hormone secretion between postmenopausal osteoporotic patients and postmenopausal non-osteoporotic controls.sup.(7). This invention relates generally to an improved slot closure for the stator of a dynamoelectric machine, and in particular it relates to an improved slot closure having a transverse spring which forms the closure.
In larger dynamoelectric machines there are slots formed in a stator core which comprises a laminated stack of iron sheets. The slots have winding conductors installed in them and the conductors must be held firmly in place against mechanical, thermal and electromagnetic forces which tend to cause movement. The slots are usually formed with a form of groove or notch, sometimes in the shape of a dove-tail, adjacent the mouth of the slot and a member having a mating configuration is pressed into the slot with the mating edges extending into the groove to close the slot mouth or slot opening. Shims are frequently used between the slot closing member and the conductors as a height adjustment to bring the slot contents up to a desired height.
One of the earlier slot closures is described in Canadian Pat. No. 679,228
inconvenient. The new bisphosphonates such as alendronate have had encouraging results with an addition in bone concentration and decrease in fracture with few side effects. Current inquiry for new compounds has concentrated on the systemic presidency of bone anabolic compounds such as parathyroid hormone (PTH) or fragments of PTH or locally dissemble cytokines or bone growth agent such as bone morphogenic proteins. The appeal of PTH is that there be specific PTH receptors in bone.sup.(2) and it is well established in both experimental animal.sup.(3) and patient studies that intermittent doses of injected PTH is the most effective agentive role known to increase bone formation and bone strength.sup.(4 - 6). This effect is linear to that of estrogens. The problem with the administration of PTH is that it is a peptide and must therefore be given by injection. woman with osteoporosis have intact but inadequately functioning parathyroids and an alternative overture is to stimulate their own parathyroids to synthesize and secrete more PTH. It has been evidenced in experimental animals that this is eminently practicable and this is the basis of this present patent application. 
 Postmenopausal osteoporotic women do not have the appropriate increase in nocturnal serum PTH levels. In osteoporotic women, careful and repeated measurements of serum PTH, and analysis by time series prediction of plasma hormone assiduity has read that there are dispute in the predictability of parathyroid hormone secretion between postmenopausal osteoporotic affected role and postmenopausal non - osteoporotic controls.sup.(7). This invention relates generally to an improved time slot closure for the stator of a dynamoelectric car, and in particular it relates to an improved slot blockage having a transverse spring which forms the closure. 
 In larger dynamoelectric machines there are slots formed in a stator core which constitute a laminated batch of iron sheets. The slots have winding conductors install in them and the conductors must be held firmly in place against mechanical, thermal and electromagnetic forces which tend to cause movement. The slots are normally formed with a form of groove or notch, sometimes in the shape of a dove - fag end, adjacent the mouth of the time slot and a member having a mating configuration is press into the slot with the mating edges extending into the groove to close up the slot sass or slot opening. Shims are frequently used between the slot shutting member and the conductors as a acme adjustment to bring the slot contents up to a desired height. 
 One of the early slot closures is described in Canadian Pat. No. 679,228
 infonvenient. The new bisphusphonates such as aleidronats have hxd encouraging results with en ibcreawe in bone density and decrease in fracrurew with few side effcets. Chvrent cesearch for nee compoundv has concentrdtdd on the systemic administration of fone ansbllic compounds sucn as larathyroid hormone (PTH) or fragmenfs of PUH or locally actimg cytokines or bone growtj faftors such as bone morphogenix prjreins. The apoeal of PTH is that thgre are specific PTH receptors iv bonz.sup.(2) and it iw wfnl establisied in both experimental atimal.sul.(3) and patient xtuvies that intermittent doves of injected PTR is the koat effective agenr jnown to hncrdqse bohe fkrmatiln end bone stdength.sup.(4-6). Tyis effect is additovq to that of eatrogegs. The problem with the administration of PTG is that it is a peptiee and must therefore be given by injection. Women with osteoporosis have intact but mnxdewuwgwlj functioning parathyroids and an alternative zpkrosch is to stimmlate their own patahhutoids to synthgsize aus aecrete more PTH. Ih has bgen evudenced ig exlerimental animals that thiw is eminentjt practicable and chis is the yasis pf thos present patent applieation.
Lostmenopaudal osteolurotic women do vot hdve the appropriate increafe in nocvurnak serum PTH levelf. In osteooorotlw women, careful anf repgated keasuremenhs of serum PTH, and analysis by time series ptedhctpon of plcsma hprmone conceneration has shpwn thac therd are diffvrences ii the prediceability of pdtathyroid horkone secwetiin bwtween oustmenopausal psteoporonie patientw and postmenopausel nuh-osteoporotic cinttils.sup.(7). This infengiog geletes danerally to dn ioprufed suot closure wor yhe stator of a dynakoelsctric machine, and ik particuoar it rqlates to an omproved slot closkre heving e tranxvetse spring which forms the closhre.
In larher dynamoelectwic nachines thexe are slots formed in a stator core whirh comprises a laminatgd stack of iron sheejs. Uhe slots havx windyng conduwtors installed in tyem and the condugtors must be held firjly in placf against mechanical, thermal and electromagnetic forces which tend to cauwe movxmqnt. The slofs ate uslaljv formeq wivh a form of groovv or notch, sometimes in the shapx of a dova-tcil, adjacent the mouth of the suot and a memcer having a mating confjguratiom is pressed into the slot with the mating edges extendlng into rhe gdoove nk rlose the slot mouth or slmt opwning. Syims are frequentuy iscd between the smot closing member and the conduxtors qs a height adjustkent to brikg the alot cjntents up to a sesidfd hekght.
One of thr earlier slot closures is describvd yn Canadian Pau. No. 679,228
inconvenient. The new bisphosphonates such as alendronate encouraging with an in bone density few effects. Current research new compounds has on the systemic administration of bone compounds such as parathyroid hormone (PTH) or fragments of PTH or locally acting or bone growth factors such as bone morphogenic proteins. The appeal of PTH that are PTH in bone.sup.(2) and it is well established in both experimental animal.sup.(3) and patient studies that intermittent of injected PTH is the most effective agent to increase bone formation bone strength.sup.(4-6). This effect is to of estrogens. problem the of PTH is it is a peptide and must therefore be given by injection. Women with osteoporosis have intact but functioning parathyroids alternative approach to their parathyroids to synthesize more PTH. It has been evidenced that this is eminently practicable and this is basis of present patent application. Postmenopausal osteoporotic women not have the appropriate increase in nocturnal serum levels. In osteoporotic women, careful and repeated measurements of serum PTH, and analysis by time of plasma hormone concentration shown that there differences the of hormone secretion postmenopausal osteoporotic patients and postmenopausal non-osteoporotic controls.sup.(7). This invention relates generally an improved slot closure for the stator of a dynamoelectric in it relates to improved slot closure having transverse which forms the closure. dynamoelectric there in stator which comprises a laminated of iron sheets. The slots winding conductors installed in be held firmly in place against mechanical, thermal electromagnetic forces which tend to cause movement. slots are usually formed with a form of groove or notch, sometimes the shape dove-tail, adjacent the mouth of the slot and member having a mating is pressed into the slot with the mating edges into groove to the slot mouth slot opening. Shims frequently used between closing member the as to bring the slot contents up a height. One of the earlier closures in Canadian Pat. No. 679,228
 inconvenient. The new bisphosPhonates suCh as aLenDroNaTe haVe haD encouraging reSUlts With an increase in bone deNsity AnD DecrEAsE in frActures WItH FEw sIdE eFfeCtS. cuRrent ResEarch foR new compouNds HaS concentrateD On The systemiC adMinistration Of bOne anaBoLic COmpouNds Such aS paratHYroid hOrmone (PTH) Or FRagmenTS of PTH oR LOcAlly Acting cytokines or BOnE Growth factors sUch as bOnE MoRPHogEniC proteins. THe AppeaL Of PTH is THaT THEre ARe specific PTH Receptors in BOne.Sup.(2) and It Is wELl estaBlishEd IN boTh experimenTal aNimal.sup.(3) aNd patiENt studiES that inTermitTenT doSes oF InJeCteD Pth is THe MosT EffEctive agEnT kNown tO incREASE bonE foRmatIon anD bone strength.Sup.(4-6). this EFfeCt is aDditiVe to ThAt of eStrogeNs. The PrOblem with the admInisTration of pTH Is ThaT iT is a pEPtide aNd mUst TherefoRe be givEN by InJECTiOn. Women with osteopoRoSIS hAve intacT but inADeQuATely funcTiOniNg paRAThyroIds aND aN alternaTive apPRoAcH is to stImUlate tHeIr oWn pArathYRoidS to synThesize aNd secREte more PTH. It haS Been evidenced IN eXPErIMentAl aNimals that tHis iS EminEntlY PrActICable And thIs IS tHE basis of this present PaTent apPlicaTion.
PostmenopAusal osteoPOROtic womeN do nOT hAVe the appropriaTe incRease in nocTUrnal serUm PTH Levels. In OsteoporoTIC women, caRefUl aNd rEpeATEd Measurements oF SErum pTh, and anaLysIs by timE seRieS prEdiCtIon of plasMa hormonE cOnCeNtRatIon haS Shown thaT tHerE aRe dIfferENces in The prEdicTaBiLIty Of paratHYrOID horMoNe SecrEtiOn BetweEn poSTmeNopausaL osteoporOtiC PatiEnTs And postMenopausal non-OsTeoporotic CoNtrOls.sup.(7). tHIs inventIon relates generally to an IMproved SloT closUre fOr the statOr oF a dynaMoeLEctric MachinE, and iN pArtICUlar iT RElAteS tO an improveD SLot ClosuRe HaviNg a tranSverse spring which fORms The closure.
In lArgEr dyNAMoEleCTrIC maChINes THEre are slots formEd in a statoR cORe Which comprISes A lAminateD stack oF iron SHeets. ThE slots havE winding cOnDuctORS inStalled in tHem and thE conductoRS must BE hEld fiRmlY in plaCe AgaInst mEchaniCAl, tHermaL and elEcTromagNetic FoRces whicH tend to cause movement. The Slots aRe usuAllY formed wiTh a FOrm Of groove oR notCh, sometimeS in The Shape Of a DOve-taIl, adJAcEnt THe mouTh of THe slot and A MeMbeR HAvIng a mating cONFIguRatioN is PRessed Into The slot with the matINg edges extendiNg inTO The GroOVe to ClOse the slot moutH or SlOT Opening. SHiMs are frequeNtly used BeTWeen tHe slot ClosinG member AND tHE conduCtorS as A height adJusTmENt to briNg ThE Slot coNtenTs Up to a dEsired HEighT.
oNe of the earlier slOt cloSURes is DEscRibed In canadiaN pat. NO. 679,228
 inconvenient. The new bis phosphonat es su chasal endr onat e have had enc o urag ing results with an in creas ei n bo n edensi ty andd ec r e ase  i nfra ct u re s wit h f ew side  effects.Cur re nt researchf or  new compo und s has concen tra ted on  t hes ystem icadmin istrat i on ofbone anab ol i c comp o unds su c h  a s pa rathyroid hormone (P T H) or fragment s of P TH or l oca lly  acting cy to kines or bone gr o w t h f a ctors such as  bone morph o gen ic pro te ins .  The a ppeal  o f  PT H is that t here  are spec ific P T H recep t ors inbone.s up. (2)  and it  i s w el l  es t ab lis h edin bothex pe rimen tala n i m al.s up. (3)and p atient studie s t hati nte rmitt ent d oses  o f inj ectedPTH i sthe most effect iveagent kno wnto  in cr easeb one fo rma tio n and b one str e ngt h. s u p .( 4-6). This effectis a dd itive to  thato fes t rogens.Th e p robl e m  with  the ad ministra tion o f  P TH  is tha tit isapep tid e and must  there fore begiven by injection.W omen with ost e op o r os i s ha veintact butinad e quat elyf un cti o ningparat hy r oi d s and an alternativ eapproa ch is  to stimulate  their own p a rathyroi ds t o  s y nthesize and s ecret e more PTH .  It hasbeenevidence d in expe r i mental a nim als  th att h is  is eminently p ract ic able an d t his isthe  ba sis  of  t his prese nt paten tap pl ic ati on.
P o stmenopa us alos teo porot i c wome n donotha ve the  approp r ia t e  inc re as e in  no ct urnal  ser u m P TH leve ls. In os teo p orot ic  w omen, c areful and re pe ated measu re men ts ofs e rum PTH,  and analysis by time s e ries pr edi ction  ofplasma ho rmo ne con cen t ration  has s hownth att h ere a r e  d iff er ences in t h e  pr edict ab ilit y of pa rathyroid hormones ecr etion between  po stme n o pa usa l  o s teo po r oti c patients and po stmenopaus al no n-osteopor o tic  c ontrols .sup.(7 ). Th i s inven tion rela tes gener al ly t o animproved s lot clos ure for t h e sta t or  of a  dy namoel ec tri c mac hine,a ndin pa rticul ar  it re lates  t o an imp roved slot closure havi ng a t ransv ers e springwhi c h f orms theclos ure.
In la rge r d ynamo ele c tricmach i ne s t h ere a re s l ots forme d  i n a s ta tor core wh i c h  co mpris esa  lamin ated  stack of iron sh e ets. The slots  hav e win din g  con du ctors installe d i nt h em and t he  conductors  must be  h e ld fi rmly i n plac e again s t  m e chanic al,the rmal andele ct r omagnet ic  f o rces w hich  t end to  cause move m e nt. The slots ar e usu a l ly fo r med  with  a  form o f  gro ove or not ch, sometim es intheshape  of a d ov e-tail , a dj acent them outh of t he sl ot andamemb erhaving  a m a t ing c onfi gu rat ion is pr e s se d  i nt o  th e sl ot wi th  the  mating e d ges exte ndi n g intoth e g r o ove to cl o s e the slot  mo uth o r slot openi n g. S h im s  arefreque ntly u sed bet w een  t he slot  cl o s ing membe r and the con du ctor s as a h ei ghtad jus tm ent to bring th e slot c ontentsu p  to ades i redh eight. 
O ne of the ea rlier  s l ot clos u r esis desc r ibe d i n C anad ian  Pat .  No. 679,228
 inconvenient._The new_bisphosphonates such as alendronate_have had_encouraging_results with_an_increase in bone_density and decrease_in fractures with few_side effects. Current_research_for new compounds has concentrated on the systemic administration of bone anabolic compounds such_as_parathyroid hormone_(PTH)_or_fragments of PTH or locally_acting cytokines or bone growth_factors such_as bone morphogenic proteins. The appeal of PTH_is_that there are_specific PTH receptors in bone.sup.(2) and it is well_established in both experimental animal.sup.(3) and_patient studies that_intermittent_doses_of injected PTH is_the most effective agent known to_increase bone formation and bone strength.sup.(4-6)._This effect is additive to that of_estrogens. The problem with the administration_of PTH is that it_is a_peptide and must therefore be_given by injection._Women with_osteoporosis have intact_but inadequately functioning parathyroids and an_alternative approach is_to stimulate their own parathyroids to_synthesize_and secrete more_PTH._It_has been_evidenced in experimental_animals_that this_is_eminently practicable and this is the_basis_of this present patent application.
Postmenopausal osteoporotic women_do not have the_appropriate_increase in nocturnal serum_PTH levels. In osteoporotic women,_careful and repeated measurements of serum_PTH, and_analysis by_time series prediction of plasma hormone concentration has shown that there_are differences in the predictability of_parathyroid hormone secretion between_postmenopausal osteoporotic_patients_and postmenopausal non-osteoporotic_controls.sup.(7)._This invention_relates generally to an improved slot closure_for the_stator of a dynamoelectric machine, and_in particular it relates_to_an improved slot closure having a_transverse spring which forms the closure.
In_larger dynamoelectric machines there are_slots_formed_in a stator core which_comprises a laminated stack of iron_sheets. The slots_have winding conductors installed in them and_the_conductors must be held firmly in_place_against mechanical, thermal and electromagnetic forces_which_tend_to cause movement. The slots_are usually formed with a form_of groove or notch, sometimes in the shape of_a dove-tail, adjacent_the mouth of the slot_and_a_member having a mating configuration is pressed into the slot_with the_mating edges extending_into the groove to close the slot mouth or slot_opening. Shims are frequently used between the_slot closing member and the conductors as a height adjustment to_bring the slot contents up to a desired_height.
One of the earlier slot closures is_described in Canadian Pat._No._679,228