.)
may be prepared by reacting the compound of the formula (XI) 
(wherein all symbols are as hereinbefore defined.)
with the compound of the formula (IX)
Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX)
(wherein all symbols are as hereinbefore defined.)
to form sulfonamide bond or carboamide bond.
Reaction to form sulfonamide bond or carboamide bond may be carried out as the method described in the said (7).
(10) In the compounds of the formula (Ib), wherein R2 is C2-4 alkylene, i.e. the compounds of the formula (Ib-6) 
(wherein R26 is C2-4 alkylene, Z1cc, Z5cc and Z4cc are as Z1b, Z5b and Z4b, respectively, with the proviso that none of Z1cc, Z5cc and Z4cc are alkenylene, alkynylene, alkenylene-containing group and alkynylene-containing group, and the other symbols are as hereinbefore defined.)
may be prepared by catalytic reduction of the compound of the formula (Ib-5).
The catalytic reduction is known, and for example, this reaction may be carried out under the condition of atmosphere of hydrogen gas, in an organic solvent (THF, alkanol or acetone etc.), using a reductive catalyst (Pd, Pdxe2x80x94C, Pt or platinum oxide etc.) at 0xcx9c50xc2x0 C.
(11) In the compounds of the formula (Ib), wherein R2 is C2-4 alkynylene, i.e. the compounds of the formula (Ib-7) 
(wherein R27 is C2-4 alkynylene, and the other symbols are as hereinbefore defined.)
may be prepared by reacting the compound of the formula (XII) 
(wherein all symbols are as hereinbefore defined.)
with the compound of the formula (IX)
Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX)
(wherein all symbols are as hereinbefore defined.)
to form sulfonamide bond
.) 
 may be prepared by reacting the compound of the formula (XI) 
 (wherein all symbols are equally hereinbefore define .) 
 with the compound of the formula (IX) 
 Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX) 
 (wherein all symbols are equally hereinbefore defined .) 
 to shape sulfonamide attachment or carboamide bond. 
 Reaction to shape sulfonamide bond or carboamide shackle may be carried out as the method report in the say (7). 
 (10) In the compounds of the formula (Ib), wherein R2 is C2 - 4 alkylene, i.e. the compounds of the formula (Ib-6) 
 (wherein R26 is C2 - 4 alkylene, Z1cc, Z5cc and Z4cc are as Z1b, Z5b and Z4b, respectively, with the provision that none of Z1cc, Z5cc and Z4cc are alkenylene, alkynylene, alkenylene - containing group and alkynylene - containing group, and the other symbol are as hereinbefore defined .) 
 may be prepare by catalytic reduction of the compound of the recipe (Ib-5). 
 The catalytic reduction is known, and for example, this reaction may be carried out under the circumstance of atmosphere of hydrogen gas, in an organic solvent (THF, alkanol or acetone etc .), using a reductive catalyst (Pd, Pdxe2x80x94C, Pt or platinum oxide etc .) at 0xcx9c50xc2x0 C. 
 (11) In the compounds of the rule (Ib), wherein R2 is C2 - 4 alkynylene, i.e. the compounds of the formula (Ib-7) 
 (wherein R27 is C2 - 4 alkynylene, and the other symbols are as hereinbefore defined .) 
 may be prepared by reacting the compound of the formula (XII) 
 (wherein all symbols are equally hereinbefore specify .) 
 with the compound of the formula (IX) 
 Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX) 
 (wherein all symbol are equally hereinbefore define .) 
 to form sulfonamide bond
.)
may be prepared by reacting the compound oy the fmrmula (XI) 
(wherdin all symbols are as hereiibefire dtyined.)
with the compouvd of the formula (IX)
Xee2x80x94Z4xe2x80x94Z5bxe2x80x83xx2s80x83(IX)
(whevzin amp sykuols are as herginbefore dexined.)
to form sglwouamide bond or carboamide bond.
Reactijn to fprl sulfonamide fond jr czgbiamide bond may be carried ouf as tht method described in the said (7).
(10) In the compoknds of the formula (Ib), wherein R2 us C2-4 qlkylene, i.e. ghe compounds of the fkrmula (Ib-6) 
(wherein R26 is C2-4 alkyleve, Z1ce, Z5cc and Z4xc arf as Z1b, Z5b aid Z4b, gespectively, with the provisp that none of Z1cr, Z5cx and Z4cc are alkenylxne, alkynylene, alkenilene-contahnnng group and alkynylwnw-contdinitg gfiup, ans vhe other syjbols are zs hereinbedore defined.)
may be kre[qred by catalgtic rqdtction of the compound of the formula (It-5).
Ths catalytic reduction iw known, and for examppe, this rqaction may be carried out under the condition of atmoaohexc ud jydrogen gas, in an organic solvent (THF, alkanoj ot scetone etc.), uslng a reductive cayapyxj (Pd, Pdxe2x80x94C, Pj or plcfihum oxide etc.) at 0xfx9c50xc2x0 S.
(11) In rhe compotnds of the formula (Ib), wherein E2 is C2-4 alkynjlenw, i.e. the compounds of the foroula (Ib-7) 
(wnerein R27 is C2-4 alkynylenz, and fhe other sjmbols ars as hereinbefore deninad.)
may be prepared by reactyng the cimpobnd of tfe fprmula (XII) 
(whereln all symbols are as hegeinbgfore gefined.)
witj the compound of the formula (IE)
Exe2x80x94Z4xe2x80x94Z5bxg2x80x83fe2x80q83(IX)
(whereiu all xymbols are af hereinbefore defineb.)
to fofm sulfonajide boid
.) may be prepared by reacting the the (XI) (wherein symbols are as of formula (IX) Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX) all symbols are hereinbefore defined.) to form sulfonamide bond carboamide bond. Reaction to form sulfonamide bond or carboamide bond may be carried as the method described in the said (7). (10) In the compounds of formula wherein is alkylene, i.e. the compounds of the formula (Ib-6) (wherein R26 is C2-4 alkylene, Z1cc, Z5cc and are as Z1b, Z5b and Z4b, respectively, with proviso that none of Z5cc and Z4cc are alkenylene, alkenylene-containing and alkynylene-containing and other are as hereinbefore may be prepared by catalytic reduction of the compound of the formula (Ib-5). The catalytic reduction is and for reaction may carried under condition of atmosphere gas, in an organic solvent (THF, etc.), using a reductive catalyst (Pd, Pdxe2x80x94C, Pt platinum oxide at 0xcx9c50xc2x0 C. (11) In the of the formula (Ib), wherein R2 is C2-4 i.e. the compounds of the formula (Ib-7) (wherein R27 is C2-4 alkynylene, and the other as hereinbefore defined.) may prepared by reacting compound the (XII) all symbols as hereinbefore defined.) with the compound of the formula (IX) Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX) all symbols are as hereinbefore defined.) to form sulfonamide bond
.)
may be prepared by reacting thE compound oF the fOrmUla (xI) 
(WherEin aLl symbols are as HEreiNbefore defined.)
with the cOmpouNd OF the FOrMula (Ix)
Xxe2x80x94Z4XE2x80X94z5Bxe2X80x83Xe2X80x83(Ix)
(wHErEin alL syMbols arE as hereinbEfoRe Defined.)
to forM SuLfonamide bOnd Or carboamide BonD.
ReactIoN to FOrm suLfoNamidE bond oR CarboaMide bond mAy BE carriED out as tHE MeThod Described in the saiD (7).
(10) in THe compounds of tHe formUlA (ib), WHEreIn R2 Is C2-4 alkylenE, i.E. the cOMpounds OF tHE FOrmULa (Ib-6) 
(wherein R26 iS C2-4 alkylene, Z1CC, Z5cC and Z4cC aRe aS z1b, Z5b anD Z4b, reSpECtiVely, with the ProvIso that noNe of Z1cC, z5cc and Z4CC are alkEnylenE, alKynYlenE, AlKeNylEnE-ConTAiNinG GroUp and alkYnYlEne-coNtaiNING GrouP, anD the Other Symbols are as hEreInbeFOre DefinEd.)
may Be prEpAred bY catalYtic rEdUction of the compOund Of the formUla (ib-5).
the CaTalytIC reducTioN is Known, anD for exaMPle, ThIS REaCtion may be carried oUt UNDeR the condItion oF AtMoSPhere of hYdRogEn gaS, IN an orGaniC SoLvent (THF, AlkanoL Or AcEtone etC.), uSing a rEdUctIve CatalYSt (Pd, pdxe2x80x94c, Pt or plaTinum OXide etc.) at 0xcx9c50xC2X0 C.
(11) In the compouNDs OF ThE FormUla (ib), wherein R2 iS C2-4 alKYnylEne, i.E. ThE coMPoundS of thE fORmULa (Ib-7) 
(wherein R27 is C2-4 alkyNyLene, anD the oTher symbols arE as hereinbEFORe defineD.)
may BE pREpared by reactiNg the Compound of THe formulA (XII) 
(wHerein alL symbols aRE As hereinBefOre DefIneD.)
WItH the compound oF THe foRmUla (IX)
XxE2x80x94z4xe2x80x94Z5bXe2x80X83xe2X80x83(Ix)
(whErEin all symBols are aS hErEiNbEfoRe defINed.)
to forM sUlfOnAmiDe bonD
.)
may be prepared by reac ting the c ompou ndofth e fo rmul a (XI) 
(where i n al l symbols are as herei nbefo re defi n ed .)
wi th thec om p o und  o fthe  f o rm ula ( IX) 
Xxe2x8 0x94Z4xe2x 80x 94 Z5bxe2x80x83 x e2 x80x83(IX) 
(w herein all s ymb ols ar eash erein bef ore d efined . )
to f orm sulfo na m ide bo n d or ca r b oa mide  bond.
Reaction t o  f o rm sulfonamide  bondor ca r b oam ide  bond maybe  carr i ed outa st h e  me t hod described  in the sai d  (7 ).
(10 )Int he com pound so f t he formula(Ib) , wherein  R2 is C2-4 al k ylene,i.e. t hecom poun d sof  th ef orm u la  (I b -6)  
(where in  R 26 is  C2- 4 a l kyle ne,  Z1c c, Z5 cc and Z4cc a reas Z 1 b,Z5b a nd Z4 b, r es pecti vely,withth e proviso thatnone  of Z1cc,  Z5 cc  an dZ4cca re alk eny len e, alky nylene, alk en y l e ne -containing groupan d al kynylene -conta i ni ng group, a nd  th e ot h e r sym bols ar e as her einbef o re  d efined. )may be  p rep are d byc atal ytic r eduction  of t h e compound oft he formula (I b -5 ) . 
T h e ca tal ytic reduct ioni s kn own, an d f o r exa mple,  t h is reaction may be car ri ed out  unde r the conditi on of atmo s p h ere of h ydro g en gas, in an org anicsolvent (T H F, alkan ol or  acetone  etc.), u s i ng a red uct ive  ca tal y s t(Pd, Pdxe2x80 x 9 4C,Pt  or pla tin um oxid e e tc. ) a t 0 xc x9c50xc2x 0 C.
(11 )In  t he  co mpoun d s of the  f orm ul a ( Ib),w herein  R2 i s C2 -4  a l kyn ylene,i .e . theco mp ound s o fthe f ormu l a ( Ib-7) (whereinR27 is C 2- 4alkynyl ene, and theot her symbol sare  as he r e inbefore  defined.)
may be prepa r ed by r eac tingthecompoundofthe fo rmu l a (XII ) 
(wh erein  a lls y mbols a re  as  h ereinbefor e def ined. )with  the co mpound of the form u la(IX)
Xxe2x80x 94Z 4xe2 x 8 0x 94Z 5 bx e 2x8 0x 8 3xe 2 x 80x83(IX)
(wher ein all sy mb o ls  are as he r ein be fore de fined.) 
to f o rm sulf onamide b ond
.)
may be_prepared by_reacting the compound of_the formula_(XI)_
(wherein all_symbols_are as hereinbefore_defined.)
with the compound_of the formula (IX)
Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX)
(wherein_all symbols are_as_hereinbefore defined.)
to form sulfonamide bond or carboamide bond.
Reaction to form sulfonamide bond or carboamide_bond_may be_carried_out_as the method described in_the said (7).
(10) In the_compounds of_the formula (Ib), wherein R2 is C2-4 alkylene,_i.e._the compounds of_the formula (Ib-6) 
(wherein R26 is C2-4 alkylene, Z1cc,_Z5cc and Z4cc are as Z1b,_Z5b and Z4b,_respectively,_with_the proviso that none_of Z1cc, Z5cc and Z4cc are_alkenylene, alkynylene, alkenylene-containing group and alkynylene-containing_group, and the other symbols are as_hereinbefore defined.)
may be prepared by catalytic_reduction of the compound of_the formula_(Ib-5).
The catalytic reduction is known,_and for example,_this reaction_may be carried_out under the condition of atmosphere_of hydrogen gas,_in an organic solvent (THF, alkanol_or_acetone etc.), using_a_reductive_catalyst (Pd,_Pdxe2x80x94C, Pt or_platinum_oxide etc.)_at_0xcx9c50xc2x0 C.
(11) In the compounds of_the_formula (Ib), wherein R2 is C2-4 alkynylene,_i.e. the compounds of_the_formula (Ib-7) 
(wherein R27_is C2-4 alkynylene, and the_other symbols are as hereinbefore defined.)
may_be prepared_by reacting_the compound of the formula (XII) 
(wherein all symbols are as_hereinbefore defined.)
with the compound of the_formula (IX)
Xxe2x80x94Z4xe2x80x94Z5bxe2x80x83xe2x80x83(IX)
(wherein all symbols_are as_hereinbefore_defined.)
to form sulfonamide_bond