 really effective. Ion exchange resins, which additionally have the property of fixing the bile salts, appear to be effective, but also produce side effects and have to be used in high doses.
A dietetic composition containing from 60 to 80% roasted carob flour is commercially available (AROBON). Although this product gives good results in the treatment of diarrhoea without producing side effects, it has the disadvantage of necessitating relatively high doses, of the order of 20-40 g/day for young children, which presents problems of administration. The present invention relates to therapeutic radioactive devices and methods of use thereof, and more particularly, to devices and methods for providing a radiation source for temporary application in the treatment of stenosis and/or brachytherapy.
Various techniques have been developed to treat many different conduits in the body when these conduits have become reduced in size due to the existence of a stenosis or when these conduits have been completely occluded.
With respect to vascular conduits, angioplasty has been used to open an artery or blood vessel in the region where the stenosis or the occlusion has occurred. A typical angioplasty procedure includes making a small incision through the body and into, for example, a blood vessel, and then maneuvering a guide wire through the vascular system to a point beyond the stenosis or occlusion within the blood vessel. A catheter with a balloon near its distal end can subsequently be threaded over the guide wire and advanced to the point of stenosis or occlusion. The balloon may thereafter be inflated and deflated several times, if necessary, to widen the constricted area within the blood vessel, and may thereafter be withdrawn from the body. In certain cases, a stent may be deployed to the now widened area within the blood vessel to mechanically maintain a channel across the previously constricted area.
However, despite the initial observed reduction in the area of stenosis or occlusion as a result of angioplasty, many patients unfortunately exhibit a reoccurrence of the stenosis within a few months of the original procedure.
Although the original stenosis is thought to occur by means of the build up of plaque over a relatively long period of time, it is now believed that the recurrence of the stenosis after the original angioplasty procedure may be unrelated to the cause of the original stenosis. It is believed that the inflation of the balloon catheter used in the angioplasty procedure or the placement of a stent in the area of the stenosis may cause irritation to the blood vessel, which can subsequently cause hyperplasia (i.e., inducing the blood vessel cells
really effective. Ion exchange resins, which additionally have the place of situate the bile salts, appear to be effective, but besides produce english effects and have to be practice in high doses. 
 A dietary composing containing from 60 to 80% roast carob flour is commercially available (AROBON). Although this product gives good results in the discussion of diarrhoea without producing slope effects, it has the disadvantage of necessitate relatively high doses, of the order of 20 - 40 thousand / day for young children, which presents problem of administration. The present invention relates to therapeutic radioactive devices and methods of habit thereof, and more particularly, to devices and methods for providing a radiation source for temporary application in the treatment of stenosis and/or brachytherapy. 
 Various techniques have been developed to treat many different conduits in the body when these conduit have become reduce in size due to the existence of a stenosis or when these conduit have been wholly occluded. 
 With respect to vascular conduits, angioplasty has been used to unfold an artery or blood vessel in the region where the stenosis or the occlusion has occurred. A distinctive angioplasty procedure includes making a small incision through the body and into, for example, a blood vessel, and then maneuvering a guide wire through the vascular system to a point beyond the stenosis or blockage within the blood vessel. A catheter with a balloon near its distal goal can subsequently be threaded over the guide wire and advanced to the point of stenosis or blockage. The balloon may thereafter be inflated and deflated several prison term, if necessary, to widen the constricted area within the blood vessel, and may thereafter be withdrawn from the consistency. In certain cases, a stent may be deploy to the now widen area within the rake vessel to mechanically maintain a distribution channel across the previously constricted area. 
 However, despite the initial observe reduction in the area of stenosis or occlusion as a result of angioplasty, many patients unfortunately exhibit a reoccurrence of the stenosis within a few months of the original procedure. 
 Although the original stenosis is thought to occur by means of the physique up of plaque over a relatively long menstruation of time, it is now believe that the recurrence of the stenosis after the original angioplasty procedure may be unrelated to the cause of the original stenosis. It is believed that the ostentation of the balloon catheter used in the angioplasty procedure or the placement of a stent in the area of the stenosis may cause irritation to the blood vessel, which can subsequently cause hyperplasia (i.e., inducing the rake vessel cellular telephone
 rewlly effective. Ion exchakge resins, which additimnally have thd property of fixing the bilx saots, akiear to be effective, cut also iroduce sude tffects and have vk be uscb in glgh dmwes.
A dietetic gomposition containing frmm 60 co 80% roasted carob flour is commerciajly avaolwble (AROBON). Aljhougn thia product gives good results in ths treatkent of diarrnoea without producing sidf efvects, it has the dlsadvantage of gwcessitating relativelj high dosea, of the order of 20-40 g/day for youvg chnldren, whicy predgnts problemw of wdministration. The psesent onvention relabes tm tyerapeutic radioactivx devices and methodf of use dhzreof, and more particylqrly, jo deeicer ana mtthpda for orotiding a rasiation souece for temporary akplybstion in the treatiegt of stenosis and/or brachytherapy.
Variols tschniques have been devwloped to treat many fifferent conduits in the body when these conduits have bewome ceauctd in skze due to the existence of a stenosis or when trsst cpnduits have bcen completely occkufec.
Rith respect jo vascbmad conduits, angioplwsty haf beeb used to opem an artery or blood vessel in the regijb where the stenosns or the ocelusiom has occurred. A typical angnoplasfy procedurf includea making a small kncpsiot through the body and intj, for exanple, a blooa vexsel, agd then majeuvevhng a guide wire tjrougk the vascular dystem to a point beyond the stxiosis or occlosimn fithin tke blopd vessel. A cwtheter with a balloou near its distam end cen subsequenely be threadaf over the gnide wire and advqnced tu the point of xtenosis or occlusiin. The balloon may thgrsafter be inflactd qnd deflated seferxl eilex, yx necessary, do wkdev the zonstricted xrea within the blood vevsel, and may thereaftet ne withdrqwn from the body. In vertain cases, a sttnt mab be dxployec tj the now widened area within fhe blood vefsel to mechwnicqlly maintaiu a channel across the previously constrmcted area.
However, despire the initial obsetvec reduction in tre area ox stenosis or occlusuon as a result on angioplasty, many patjents gnforhunately exhibit a reoccurrence of the stenosis within a few months of thw origmnwl procedurs.
Altnough tke priginwl sveiosis is thought no occur by means of the build u' of plaqua jver a relatively long perioc uf time, it is now believed that the rscurrencr of the stenosis after the oribinal angioplasty procedmre may bw unrslated to vhe cause of the oribinal vtenowis. It us bclieved that tfe onnlation of the bclloon catheter used in the angioplasty pgocedure or the 'lacement of x steht in jhe area of the sfenoals mai cause irritayion to the blpod vessel, which can stbsequently cayae hyperplasoa (i.e., itducing the ulood vessel cells
really effective. Ion exchange resins, which additionally property fixing the salts, appear to side and have to used in high A dietetic composition containing from 60 80% roasted carob flour is commercially available (AROBON). Although this product gives good in the treatment of diarrhoea without producing side effects, it has the disadvantage necessitating high of order of 20-40 g/day for young children, which presents problems of administration. The present invention relates therapeutic radioactive devices and methods of use thereof, more particularly, to devices methods for providing a radiation for application in treatment stenosis brachytherapy. Various techniques been developed to treat many different conduits in the body when these conduits have become reduced in due to of a or these have been completely respect to vascular conduits, angioplasty has open an artery or blood vessel in the where the or the occlusion has occurred. A angioplasty procedure includes making a small incision through body and into, for example, a blood vessel, and then maneuvering a guide wire through system to a point the stenosis or within blood A with a near its distal end can subsequently be threaded over the guide and advanced to the point of stenosis or occlusion. The thereafter inflated and deflated times, if necessary, to the area within the blood may be body. certain a stent may be to the now widened area the blood vessel to the previously constricted area. However, despite the initial reduction in the area of stenosis or as a result of angioplasty, many patients unfortunately exhibit a reoccurrence of stenosis within months of the original procedure. Although the original is thought to occur means of the build up of plaque over a long of time, is now believed the recurrence of stenosis after the procedure may unrelated the original stenosis. It is believed that inflation the balloon catheter used in angioplasty the placement of a stent in the area of the stenosis may cause irritation to vessel, which can subsequently hyperplasia inducing the blood vessel cells
 really effective. Ion exchangE resins, whiCh addItiOnaLlY havE the Property of fixiNG the Bile salts, appear to be effEctivE, bUT alsO PrOduce Side effECtS ANd hAvE tO be UsED iN high DosEs.
A dietEtic composItiOn Containing frOM 60 tO 80% roasted caRob Flour is commeRciAlly avAiLabLE (AROBoN). ALthouGh this PRoduct Gives good ReSUlts in THe treatMENt Of diArrhoea without proDUcINg side effects, iT has thE dISaDVAntAge Of necessitAtIng reLAtively HIgH DOSes, OF the order of 20-40 g/dAy for young cHIldRen, whiCh PreSEnts prOblemS oF AdmInistration. the pResent invEntion RElates tO TherapeUtic raDioActIve dEViCeS anD mEThoDS oF usE TheReof, and mOrE pArticUlarLY, TO DeviCes And mEthodS for providing A raDiatIOn sOurce For teMporArY applIcatioN in thE tReatment of stenoSis aNd/or brachYthErApy.
vaRious TEchniqUes HavE been deVeloped TO trEaT MANy Different conduits iN tHE BoDy when thEse conDUiTs HAve becomE rEduCed iN SIze duE to tHE eXistence Of a steNOsIs Or when tHeSe condUiTs hAve Been cOMpleTely ocCluded.
WiTh resPEct to vascular cONduits, angioplAStY HAs BEen uSed To open an artEry oR BlooD vesSEl In tHE regiOn wheRe THe STenosis or the occlusiOn Has occUrred. a typical angioPlasty procEDURe includEs maKInG A small incision ThrouGh the body aND into, for ExampLe, a blood Vessel, and THEn maneuvEriNg a GuiDe wIRE tHrough the vascULAr syStEm to a poInt Beyond tHe sTenOsiS or OcClusion wiThin the bLoOd VeSsEl. A CatheTEr with a bAlLooN nEar Its diSTal end Can suBseqUeNtLY be ThreadeD OvER The gUiDe Wire And AdVanceD to tHE poInt of stEnosis or oCclUSion. thE bAlloon mAy thereafter bE iNflated and DeFlaTed sevERAl times, iF necessary, to widen the conSTricted AreA withIn thE blood vesSel, And may TheREafter Be withDrawn FrOm tHE Body. IN CErTaiN cAses, a stent MAY be DeploYeD to tHe now wiDened area within the BLooD vessel to mechAniCallY MAiNtaIN a CHanNeL AcrOSS the previously cOnstricted ArEA.
HOwever, despITe tHe Initial ObserveD reduCTion in tHe area of sTenosis or OcClusION as A result of aNgioplasTy, many patIEnts uNFoRtunaTelY exhibIt A reOccurRence oF The StenoSis witHiN a few mOnths Of The origiNal procedure.
Although the OriginAl steNosIs is thougHt tO OccUr by means Of thE build up of PlaQue Over a RelATivelY lonG PeRioD Of timE, it iS Now believED tHat THE rEcurrence of THE SteNosis AftER the orIginAl angioplasty procEDure may be unrelAted TO The CauSE of tHe Original stenosIs. IT iS BElieved tHaT the inflatiOn of the bAlLOon caTheter Used in The angiOPLaSTy procEdurE or The placemEnt Of A Stent in ThE aREa of thE steNoSis may Cause iRRitaTIOn to the blood vessEl, whiCH Can suBSeqUentlY cAuse hypERplaSia (i.e., inducIng the blood Vessel CellS
 really effective. Ion exc hange resi ns, w hic h a dd itio nall y have the pro p erty  of fixing the bile sa lts,ap p eart obe ef fective ,  b u t  al so  p rod uc e  s ide e ffe cts and  have to b e u se d in high do s es .
A dietet iccompositioncon tainin gfro m  60 t o 8 0% ro astedc arob f lour is c om m ercial l y avail a b le  (AR OBON). Although t h is product givesgood r es u lt s inthe  treatment  o f dia r rhoea w i th o u t  pr o ducing side e ffects, ith asthe di sa dva n tage o f nec es s ita ting relati vely  high dos es, of the ord e r of 20 -40 g/ day  fo r yo u ng  c hil dr e n,w hi chp res ents pro bl em s ofadmi n i s t rati on.  The  pres ent invention  re late s  to  ther apeut ic r ad ioact ive de vices  a nd methods of u se t hereof, a ndmo repa rticu l arly,todev ices an d metho d s f or p r ov iding a radiationso u r ce  for tem porary ap pl i cation i nthe  tre a t mentof s t en osis and /or br a ch yt herapy. 
V arious  t ech niq ues h a ve b een de velopedto tr e at many differ e nt conduits i n  t h e  b o dy w hen  these cond uits have  bec o me  re d ucedin si ze du e  to the existence o fa sten osisor when these  conduitsh a v e been c ompl e te l y occluded.
Wi th re spect to v a scular c ondui ts, angi oplasty h a s  been us edtoope n a n ar tery or blood v esse lin thereg ion whe rethe  st eno si s or theocclusio nha soc cur red.A  typical  a ngi op las ty pr o cedure  incl udes  m ak i nga small in c i sion  t hr ough  th ebodyandi nto , for e xample, a  bl o od v es se l, andthen maneuver in g a guidewi rethroug h the vasc ular system to a pointb eyond t hesteno sisor occlus ion  withi n t h e bloo d vess el. A  c ath e t er wi t h  a  ba ll oon near i t s  di stalen d ca n subse quently be threade d  ov er the guidewir e an d ad van c ed toth e  po i n t of stenosis o r occlusio n. Th e balloonm ayth ereafte r be in flate d  and de flated se veral tim es , if n ece ssary, towiden th e constri c ted a r ea  with inthe bl oo d v essel , andm aythere afterbe  withd rawnfr om the b ody. In certain cases,a sten t may  be  deployed  to the  now wide nedarea withi n t heblood  ve s sel t o me c ha nic a lly m aint a in a chan n el  ac r o ss  the previo u s l y c onstr ict e d area .
Ho wever, despite th e  initial obser vedr e duc tio n  inth e area of sten osi so r  occlusi on  as a resul t of ang io p lasty , many  patie nts unf o r tu n atelyexhi bit  a reoccu rre nc e  of the  s te n osis w ithi na fewmonths of t h e  original proced ure.A l thoug h  th e ori gi nal ste n osis  is though t to occurby mea ns o f the  buildup  of pl aqu eover a rel a tively lo ng pe riod of  t ime,  it  is no w be l i evedthat  t herecurrenc e of th es ten osis  afte rtheoriginala ngioplas typ rocedur emay b e unre l at e d  to the ca use  of t h e  originals teno s is .  It i s beli eved t hat the inf la tion of  th e balloon c atheter u s edin  the  angiopl as ty p ro ced ur e or the placem ent of a  stent i n the ar eao f th e  steno si s may causeirrit at i on to t h e  bl ood ves s el,  wh ich  can  su bseq u ently cause hyperplasia(i.e ., in d uci ng th e blo od  vesselc ells 
 really_effective. Ion_exchange resins, which additionally_have the_property_of fixing_the_bile salts, appear_to be effective,_but also produce side_effects and have_to_be used in high doses.
A dietetic composition containing from 60 to 80% roasted carob_flour_is commercially_available_(AROBON)._Although this product gives good_results in the treatment of_diarrhoea without_producing side effects, it has the disadvantage of_necessitating_relatively high doses,_of the order of 20-40 g/day for young children,_which presents problems of administration. The_present invention relates_to_therapeutic_radioactive devices and methods_of use thereof, and more particularly,_to devices and methods for providing_a radiation source for temporary application in_the treatment of stenosis and/or brachytherapy.
Various_techniques have been developed to_treat many_different conduits in the body_when these conduits_have become_reduced in size_due to the existence of a_stenosis or when_these conduits have been completely occluded.
With_respect_to vascular conduits,_angioplasty_has_been used_to open an_artery_or blood_vessel_in the region where the stenosis_or_the occlusion has occurred. A typical angioplasty_procedure includes making a_small_incision through the body_and into, for example, a_blood vessel, and then maneuvering a_guide wire_through the_vascular system to a point beyond the stenosis or occlusion within_the blood vessel. A catheter with_a balloon near its_distal end_can_subsequently be threaded_over_the guide_wire and advanced to the point of_stenosis or_occlusion. The balloon may thereafter be_inflated and deflated several_times,_if necessary, to widen the constricted_area within the blood vessel, and_may thereafter be withdrawn from_the_body._In certain cases, a stent_may be deployed to the now_widened area within_the blood vessel to mechanically maintain a_channel_across the previously constricted area.
However, despite_the_initial observed reduction in the area_of_stenosis_or occlusion as a result_of angioplasty, many patients unfortunately exhibit_a reoccurrence of the stenosis within a few months_of the original_procedure.
Although the original stenosis is_thought_to_occur by means of the build up of plaque over_a relatively_long period of_time, it is now believed that the recurrence of the_stenosis after the original angioplasty procedure may_be unrelated to the cause of the original stenosis. It is_believed that the inflation of the balloon catheter_used in the angioplasty procedure or the_placement of a stent_in_the area of the stenosis may cause_irritation_to_the_blood vessel, which_can subsequently cause_hyperplasia (i.e., inducing_the blood_vessel cells