RS(O)2-substituted aryl, xe2x80x94NRS(O)2-heteroaryl, xe2x80x94NRS(O)2-substituted heteroaryl, xe2x80x94NRS(O)2-heterocyclic, xe2x80x94NRS(O)2-substituted heterocyclic, xe2x80x94NRS(O)2xe2x80x94NR-alkyl, xe2x80x94NRS(O)2xe2x80x94NR-substituted alkyl, xe2x80x94NRS(O)2xe2x80x94NR-aryl, xe2x80x94NRS(O)2xe2x80x94NR-substituted aryl, xe2x80x94NRS(O)2xe2x80x94NR-heteroaryl, xe2x80x94NRS(O)2xe2x80x94NR-substituted heteroaryl, xe2x80x94NRS(O)2xe2x80x94NR-heterocyclic, xe2x80x94NRS(O)2xe2x80x94NR-substituted heterocyclic where R is hydrogen or alkyl, mono- and di-alkylamino, mono-and di-(substituted alkyl)amino, mono- and di-arylamino, mono- and di-substituted arylamino, mono- and di-heteroarylamino, mono- and di-substituted heteroarylamino, mono- and di-heterocyclic amino, mono- and di-substituted heterocyclic amino, unsymmetric di-substituted amines having different substituents selected from alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic and substituted alkynyl groups having amino groups blocked by conventional blocking groups such as Boc, Cbz, formyl, and the like or alkynyl/substituted alkynyl groups substituted with xe2x80x94SO2-alkyl, xe2x80x94SO2-substituted alkyl, xe2x80x94SO2-alkenyl, xe2x80x94SO2-substituted alkenyl, xe2x80x94SO2-cycloalkyl, xe2x80x94SO2-substituted cycloalkyl, xe2x80x94SO2-aryl, xe2
RS(O)2 - substituted aryl, xe2x80x94NRS(O)2 - heteroaryl, xe2x80x94NRS(O)2 - substituted heteroaryl, xe2x80x94NRS(O)2 - heterocyclic, xe2x80x94NRS(O)2 - substituted heterocyclic, xe2x80x94NRS(O)2xe2x80x94NR - alkyl, xe2x80x94NRS(O)2xe2x80x94NR - substitute alkyl, xe2x80x94NRS(O)2xe2x80x94NR - aryl, xe2x80x94NRS(O)2xe2x80x94NR - substitute aryl, xe2x80x94NRS(O)2xe2x80x94NR - heteroaryl, xe2x80x94NRS(O)2xe2x80x94NR - substituted heteroaryl, xe2x80x94NRS(O)2xe2x80x94NR - heterocyclic, xe2x80x94NRS(O)2xe2x80x94NR - substituted heterocyclic compound where R is hydrogen or alkyl, mono- and di - alkylamino, mono - and di-(substituted alkyl)amino, mono- and di - arylamino, mono- and di - substituted arylamino, mono- and di - heteroarylamino, mono- and di - substituted heteroarylamino, mono- and di - heterocyclic amino, mono- and di - substitute heterocyclic amino, unsymmetric di - substituted amines have different substituents selected from alkyl, substitute alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic and substitute alkynyl groups having amino groups blocked by conventional blocking group such as Boc, Cbz, formyl, and the like or alkynyl / substituted alkynyl groups substitute with xe2x80x94SO2 - alkyl, xe2x80x94SO2 - substituted alkyl, xe2x80x94SO2 - alkenyl, xe2x80x94SO2 - substituted alkenyl, xe2x80x94SO2 - cycloalkyl, xe2x80x94SO2 - substituted cycloalkyl, xe2x80x94SO2 - aryl, xe2
RS(O)2-dubstituted aryl, xe2x80x94NRS(U)2-heteroaryl, xe2x80r94BRS(O)2-suustitutsd heteruaryl, xe2x80x94NRS(O)2-heterocyclic, xx2x80x94NES(O)2-suvstituted heterocyclic, xe2x80x94NRS(O)2qe2x80x94NR-alktl, xt2x80x94NRS(O)2xe2x80x94NR-subsvjtuted alkyl, sc2x80x94NRV(I)2xe2x80x94NR-aryl, xe2w80x94NRS(O)2xe2x80x94NS-substituted asyu, re2x80x94NRS(O)2xe2x80x94NR-heteroaryl, xe2x80x94NRS(O)2xe2x80v94NR-subsyihuted heteroaril, xe2q80x94GRS(O)2sv2x80w94NR-heterocyclic, xe2x80x94NRS(O)2xe2x80x94NR-sugstituttd heterocyclic whrre R is hydrogen or alkyl, monl- and di-alkylamino, mono-and di-(wubseututed alkyl)xmino, mono- and di-arylajino, mono- and di-substituted aryuaminp, mono- and du-hehgroarylamino, mono- and di-substlnuted hateroarulamino, mono- akd di-ieteeocyclic amino, mono- aid di-substituted hetgrocyclic dmnno, unsymmetric di-subwtututeg amhnes yavkng dmffsrent dubatituents aelected frim alkyl, substitutec wokyl, aryl, subatitutqd aryl, heteroaryl, substituted heteroaryl, heferocyclic and substitured heterocyclic and dubstitutqd alkynyl groups having amino groups blocked by wonveitkonco blozjijg groups such as Boc, Cbz, formyl, and the like kr akkynyl/substitubed alkynyl groups skbxjituted with xg2x80x94SO2-alkyl, xe2x80x94SO2-substituted alkyl, ve2x80x94SI2-alkenyl, ve2x80x94XO2-substituted alkenyl, xe2x80x94SI2-cycloalkyl, qe2x80x94WO2-substituted cycllalkyl, xe2x80x94RO2-aril, xe2
RS(O)2-substituted aryl, xe2x80x94NRS(O)2-heteroaryl, xe2x80x94NRS(O)2-substituted heteroaryl, xe2x80x94NRS(O)2-heterocyclic, xe2x80x94NRS(O)2-substituted xe2x80x94NRS(O)2xe2x80x94NR-substituted xe2x80x94NRS(O)2xe2x80x94NR-aryl, xe2x80x94NRS(O)2xe2x80x94NR-substituted xe2x80x94NRS(O)2xe2x80x94NR-heteroaryl, xe2x80x94NRS(O)2xe2x80x94NR-substituted heteroaryl, is or alkyl, mono- di-alkylamino, mono-and di-(substituted mono- and di-arylamino, mono- and di-substituted mono- and di-heteroarylamino, mono- and di-substituted heteroarylamino, mono- and di-heterocyclic amino, mono- and heterocyclic amino, unsymmetric di-substituted amines having different substituents selected from alkyl, substituted alkyl, substituted heteroaryl, heteroaryl, and substituted heterocyclic and substituted alkynyl groups having amino groups blocked by conventional blocking groups such Boc, Cbz, formyl, and the like or alkynyl/substituted groups substituted with xe2x80x94SO2-alkyl, alkyl, xe2x80x94SO2-alkenyl, xe2x80x94SO2-substituted alkenyl, xe2x80x94SO2-cycloalkyl, cycloalkyl, xe2
RS(O)2-substituted aryl, xe2x80x94NRS(o)2-heteroaryL, xe2x80x94nRS(o)2-suBsTituTed hEteroaryl, xe2x80x94Nrs(O)2-heTerocyclic, xe2x80x94NRS(O)2-subsTitutEd HEterOCyClic, xE2x80x94NRS(O)2XE2x80X94nr-alKyL, xE2x80x94nRs(o)2xE2x80x94NR-SubStituteD alkyl, xe2x80x94nRS(o)2xE2x80x94NR-aryl, xe2x80X94nRs(O)2xe2x80x94NR-suBstItuted aryl, xe2X80x94NrS(O)2xe2x80X94Nr-heTEroarYl, xE2x80x94NRs(O)2xe2x80x94nr-substItuted hetErOAryl, xe2X80X94NRS(O)2xe2X80X94nR-HeteRocyclic, xe2x80x94NRS(O)2xE2X80x94nr-substituted heTerocyClIC wHERe R Is hYdrogen or aLkYl, monO- And di-alKYlAMINo, mONo-and di-(substiTuted alkyl)aMIno, Mono- anD dI-arYLamino, Mono- aNd DI-suBstituted arYlamIno, mono- anD di-hetERoarylaMIno, mono- And di-sUbsTitUted HEtErOarYlAMinO, MoNo- aND di-HeterocyClIc Amino, Mono- AND DI-subStiTuteD heteRocyclic amino, UnsYmmeTRic Di-subStituTed aMiNes haVing diFfereNt Substituents selEcteD from alkyL, suBsTitUtEd alkYL, aryl, sUbsTitUted aryL, heteroARyl, SuBSTItUted heteroaryl, heteRoCYClIc and subStitutED hEtERocyclic AnD suBstiTUTed alKynyL GrOups haviNg aminO GrOuPs blockEd By convEnTioNal BlockINg grOups suCh as Boc, CBz, forMYl, and the like or ALkynyl/substitUTeD ALkYNyl gRouPs substitutEd wiTH xe2x80X94SO2-aLKyL, xe2X80X94SO2-suBstitUtED aLKyl, xe2x80x94SO2-alkenyl, xe2x80X94So2-substItuteD alkenyl, xe2x80x94So2-cycloalkyL, XE2X80x94SO2-subsTituTEd CYcloalkyl, xe2x80x94So2-aryl, Xe2
RS(O)2-substituted aryl, x e2x80x94NR S(O)2 -he ter oa ryl,  xe2 x80x94NRS(O)2- s ubst ituted heteroaryl, xe2 x80x9 4N R S(O) 2 -h etero cyclic, xe 2 x 80x 94 NR S(O )2 - su bstit ute d heter ocyclic, x e2x 80 x94NRS(O)2xe 2 x8 0x94NR-alk yl,  xe2x80x94NR S(O )2xe2x 80 x94 N R-sub sti tuted  alkyl ,  xe2x8 0x94NRS(O )2 x e2x80x 9 4NR-ary l ,  x e2x8 0x94NRS(O)2xe2x80 x 94 N R-substitutedaryl,xe 2 x8 0 x 94N RS( O)2xe2x80x 94 NR-he t eroaryl ,  x e 2 x 80x 9 4NRS(O)2xe2x8 0x94NR-subs t itu ted he te roa r yl, xe 2x80x 94 N RS( O)2xe2x80x9 4NR- heterocyc lic, x e 2x80x94 N RS(O)2x e2x80x 94N R-s ubst i tu te d h et e roc y cl icw her e R is h yd ro gen o r al k y l ,  mon o-anddi-al kylamino, mon o-a nd d i -(s ubsti tuted  alk yl )amin o, mon o- an ddi-arylamino, m ono-  and di-s ubs ti tut ed  aryl a mino,mon o-and di- heteroa r yla mi n o ,  m ono- and di-substi tu t e dheteroar ylamin o ,mo n o- and d i- het eroc y c lic a mino ,  m ono- and  di-su b st it uted he te rocycl ic  am ino , uns y mmet ric di -substit uteda mines having d i fferent subst i tu e n ts sele cte d from alky l, s u bsti tute d  a lky l , ary l, su bs t it u ted aryl, heteroary l,  subst itute d heteroaryl,  heterocyc l i c  and sub stit u te d  heterocyclicand s ubstituted alkynylgroup s having  amino gr o u ps block edbycon ven t i on al blocking g r o upssu ch as B oc,  Cbz, f orm yl,  an d t he  like oralkynyl/ su bs ti tu ted  alky n yl group ssub st itu ted w i th xe2 x80x9 4SO2 -a lk y l,xe2x80x 9 4S O 2 -sub st it uted  al ky l, xe 2x80 x 94S O2-alke nyl, xe2x 80x 9 4SO2 -s ub stitute d alkenyl, xe 2x 80x94SO2-c yc loa lkyl,x e 2x80x94S O2-substituted cycloalk y l, xe2x 80x 94SO2 -ary l, xe2
RS(O)2-substituted aryl,_xe2x80x94NRS(O)2-heteroaryl, xe2x80x94NRS(O)2-substituted_heteroaryl, xe2x80x94NRS(O)2-heterocyclic, xe2x80x94NRS(O)2-substituted heterocyclic,_xe2x80x94NRS(O)2xe2x80x94NR-alkyl, xe2x80x94NRS(O)2xe2x80x94NR-substituted_alkyl,_xe2x80x94NRS(O)2xe2x80x94NR-aryl, xe2x80x94NRS(O)2xe2x80x94NR-substituted_aryl,_xe2x80x94NRS(O)2xe2x80x94NR-heteroaryl, xe2x80x94NRS(O)2xe2x80x94NR-substituted heteroaryl,_xe2x80x94NRS(O)2xe2x80x94NR-heterocyclic, xe2x80x94NRS(O)2xe2x80x94NR-substituted heterocyclic_where R is hydrogen_or alkyl, mono-_and_di-alkylamino, mono-and di-(substituted alkyl)amino, mono- and di-arylamino, mono- and di-substituted arylamino, mono- and di-heteroarylamino,_mono-_and di-substituted_heteroarylamino,_mono-_and di-heterocyclic amino, mono- and_di-substituted heterocyclic amino, unsymmetric di-substituted_amines having_different substituents selected from alkyl, substituted alkyl, aryl,_substituted_aryl, heteroaryl, substituted_heteroaryl, heterocyclic and substituted heterocyclic and substituted alkynyl groups_having amino groups blocked by conventional_blocking groups such_as_Boc,_Cbz, formyl, and the_like or alkynyl/substituted alkynyl groups substituted_with xe2x80x94SO2-alkyl, xe2x80x94SO2-substituted alkyl, xe2x80x94SO2-alkenyl, xe2x80x94SO2-substituted_alkenyl, xe2x80x94SO2-cycloalkyl, xe2x80x94SO2-substituted cycloalkyl, xe2x80x94SO2-aryl, xe2