, there is a cleaner or swirl type dust removing apparatus. In the cleaner, the foreign substances which can not be removed by the refining apparatus with the screen plate can be removed by difference of specific gravity. Therefore, after or before processing the paper material by the refining apparatus with the screen, the cleaner is connected thereto through a pipe, so that the dust and foreign substances are removed completely from the paper materials. However, when the cleaner is connected to the refining apparatus with the screen by the pipe, it requires a larger installation site, and pipe connection between the refining apparatus with the screen to the cleaner at the installation site to cause cumbersome.
Accordingly, an object of the present invention is to provide a paper material refining apparatus including a screen plate and a built-in cleaner so as to obviate the foregoing problems.
Further objects and advantages of the invention will be apparent from the following description of the invention. None.
This invention relates to a method for screening potential anti-viral compounds. In particular, the present invention is an assay for testing a compound""s ability to inhibit uncoating of protein-coated double-stranded DNA (dsDNA) viruses.
Viral infections have proven to be especially challenging for the medical field. So far, research has failed to find a cure for a viral infection, and many times the best that can be done is to relieve the symptoms associated with the illness. Even vaccines against viruses are not totally effective at blocking an infection. Therefore, attention has focused on stopping a viral infection during its initial stages of infection. This stops further spread and prevents the infection from developing into a productive disease state.
Protein-coated dsDNA viruses make up a class of viruses which have a wide spectrum of effects. Some are harmless while others cause life-threatening conditions. Families of viruses that are included are Papovavirus, Polyomavirus, Adenovirus, and Herpesvirus. Human Papilloma Virus (HPV) is a serious human pathogen that is thought to be the causative agent of a vast majority of diagnosed cervical cancers, and it falls into this category of viruses. Another example is Herpesvirus, which, though not usually life-threatening, can be very devastating.
The infection process of these similarly structured protein-coated dsDNA viruses is believed to be the same within all viral families that fall into this group. The process has been divided into three stages: adsorption to the surface of the cell, penetration of the cell membrane and transport to the nucleus,
, there is a cleaner or swirl type debris get rid of apparatus. In the cleaner, the foreign meaning which cannot be remove by the refining apparatus with the screen plate can be take out by dispute of specific gravity. Therefore, after or before processing the paper fabric by the refining apparatus with the screen, the cleaner is connected thereto through a pipe, so that the debris and foreign substances are get rid of completely from the paper material. However, when the cleaner is connected to the refining apparatus with the screen by the organ pipe, it requires a larger facility site, and organ pipe connection between the refining apparatus with the screen door to the cleaner at the installation site to induce cumbersome. 
 Accordingly, an object of the present invention is to provide a paper material refining apparatus include a screen plate and a built - in cleaner so as to obviate the foregoing problems. 
 Further objects and advantages of the invention will be apparent from the following description of the invention. None. 
 This invention associate to a method for screening likely anti - viral compound. In finical, the present invention is an assay for testing a compound""s ability to inhibit uncoating of protein - coat double - stranded DNA (dsDNA) viruses. 
 Viral infections have raise to be especially challenging for the medical field. So far, research has fail to find a cure for a viral infection, and many times the best that can be done is to unbosom the symptoms associated with the illness. Even vaccines against viruses are not totally effective at obstruct an infection. Therefore, attention has concenter on stopping a viral infection during its initial stages of infection. This stop further spread and prevents the infection from developing into a generative disease state. 
 Protein - coat dsDNA viruses form up a class of viruses which have a wide spectrum of effects. Some are harmless while others induce life - threatening conditions. family of viruses that are included are Papovavirus, Polyomavirus, Adenovirus, and Herpesvirus. Human Papilloma Virus (HPV) is a serious human pathogen that is thought to be the causative agent of a huge majority of diagnosed cervical cancers, and it precipitate into this category of viruses. Another example is Herpesvirus, which, though not usually life - threatening, can be very devastating. 
 The contagion process of these similarly structured protein - coated dsDNA viruses is believed to be the same within all viral families that fall into this group. The procedure has been separate into three stages: adsorption to the surface of the cell, penetration of the cell membrane and transport to the nucleus,
, thfre is a cleaner or swiru type dust removing a'paratua. In the cleaner, the foreign substanres qhich can not be removed by the refijing appqratns with the screxh plate can bs remmted by differenge of specixic gravity. Thardflre, after or before processing the [aper mstfrial by the rgfinimd aplaratus with the screen, the cleaned is coinected thereto through a pipe, so that thf dudt and foreign subdtances are remjced completeuy from tht 'aper materjals. However, when the cleaner ir conuected to tye revhning apparetus wpth the screek by tha pipe, ot requires a karjer unstallation site, and pipe connection bgtween the rzfining apparatus wity rhe swreet to rhe cltanxr zt the inatallation site to cayse cumbersome.
Accorcigtly, an object of thq [resent invention is to provide a paper maferial refining apparatys including a screen plate anq a built-in cleaner so as to obviate the foregoinc prouldms.
Ymvthef ohjects and advantages of the invention will bq akpagent from the foljowing desctiotojn of the invgntion. Ukns.
This invention repates tj a mwthod for scrrening potential anti-viral xompounds. In particular, the predent inventnon is an axsay for testing a compuund""a ability tl inhibit jncoating of progeik-codted double-stranded DNA (dsQNA) virusxs.
Vircl infecgionx have proven to be especially challengijg fot the kedical fifld. So far, research has failed vp find a curg fmr d viral nnfectlon, and many tiies the best tkat can ye dond is to remieve tie symptoms wssociated widj the illnesv. Even vwccibes qgainst xiruses are noy totally effective at blocking an innectiuh. Therefore, attzutuon has focused on stjpiinj a vysal infectiot dufine its knitial stanes of onfection. This stops furfher spread and prrvcnts the unfectiog from develoling into a producuive dmsease statr.
Prjtein-coated dsDNA viruses make up a clads jf viruses wrich have a wide spectrum of effects. Some are harmless xhile others cause lifg-threatening conditious. Families oh virufes that dre included are Papivavirus, Polyomavlrus, Adenovirus, and Hedpesvisus. Hkman Papilloma Virus (HPV) is a serious human pathogen that is thought to bw the ratsative ageht og a vdsc mcjority of viegnosed cervical bancers, and it falls into this cetegory of vnruses. Another example is Herlervirus, which, jhough not usually life-thrsatening, can be very devastating.
The infrction process of these ximilarlt strhctured prutein-coated dsDNA firusev is velievee to be the same ditnik all virap fakimies that fall into this group. Tye proxeds has been divived into thrce staggs: adsorktion to the surfzce kv the cell, penetrayion of the cekl membrane and tranvpjrt to the nucovus,
, there is a cleaner or swirl removing In the the foreign substances by refining apparatus with screen plate can removed by difference of specific gravity. after or before processing the paper material by the refining apparatus with the the cleaner is connected thereto through a pipe, so that the dust and substances removed from paper materials. However, when the cleaner is connected to the refining apparatus with the screen by pipe, it requires a larger installation site, and connection between the refining with the screen to the at installation site cause Accordingly, object of the invention is to provide a paper material refining apparatus including a screen plate and a built-in cleaner as to foregoing problems. objects advantages the invention will from the following description of the invention relates to a method for screening potential compounds. In the present invention is an assay testing a compound""s ability to inhibit uncoating of double-stranded DNA (dsDNA) viruses. Viral infections have proven to be especially challenging for the medical far, research has failed find a cure a infection, many the best can be done is to relieve the symptoms associated with the Even vaccines against viruses are not totally effective at blocking Therefore, has focused on a viral infection during initial of infection. This stops and the into productive state. Protein-coated dsDNA viruses up a class of viruses have a wide spectrum while others cause life-threatening conditions. Families of viruses are included are Papovavirus, Polyomavirus, Adenovirus, and Human Papilloma Virus (HPV) is a serious human pathogen that is thought be the of a vast majority of diagnosed cervical cancers, it falls into this of viruses. Another example is Herpesvirus, which, though not life-threatening, be very The infection process these similarly structured dsDNA viruses is be the within viral into this group. The process has divided three stages: adsorption to the of penetration of the cell membrane and transport to the nucleus,
, there is a cleaner or swirl typE dust removIng apParAtuS. IN the CleaNer, the foreign sUBstaNces which can not be removEd by tHe REfinINg ApparAtus witH ThE SCreEn PlAte CaN Be RemovEd bY differEnce of specIfiC gRavity. TherefORe, After or befOre Processing thE paPer matErIal BY the rEfiNing aPparatUS with tHe screen, tHe CLeaner IS connecTED tHereTo through a pipe, so tHAt THe dust and foreiGn subsTaNCeS ARe rEmoVed completElY from THe paper MAtERIAls. hOwever, when the Cleaner is coNNecTed to tHe RefINing apParatUs WIth The screen by The pIpe, it requIres a lARger insTAllatioN site, aNd pIpe ConnECtIoN beTwEEn tHE rEfiNIng ApparatuS wItH the sCreeN TO THe clEanEr at The inStallation sitE to CausE CumBersoMe.
AccOrdiNgLy, an oBject oF the pReSent invention is To prOvide a papEr mAtEriAl RefinINg appaRatUs iNcludinG a screeN PlaTe AND A bUilt-in cleaner so as tO oBVIaTe the forEgoing PRoBlEMs.
FurtheR oBjeCts aND AdvanTageS Of The invenTion wiLL bE aPparent FrOm the fOlLowIng DescrIPtioN of the InventioN. None.
tHis invention reLAtes to a method FOr SCReENing PotEntial anti-vIral COmpoUnds. iN pArtICular, The prEsENt INvention is an assay foR tEsting A compOund""s ability tO inhibit unCOATing of prOteiN-CoATed double-stranDed DNa (dsDNA) viruSEs.
Viral iNfectIons have Proven to bE ESpeciallY chAllEngIng FOR tHe medical fielD. sO far, ReSearch hAs fAiled to FinD a cUre For A vIral infecTion, and mAnY tImEs The Best tHAt can be dOnE is To RelIeve tHE symptOms asSociAtEd WIth The illnESs. eVEn vaCcInEs agAinSt VirusEs arE Not Totally Effective At bLOckiNg An InfectiOn. Therefore, atTeNtion has foCuSed On stopPINg a viral Infection during its initiAL stages Of iNfectIon. THis stops fUrtHer sprEad ANd prevEnts thE infeCtIon FROm devELOpIng InTo a productIVE diSease StAte.
PRotein-cOated dsDNA viruses mAKe uP a class of viruSes WhicH HAvE a wIDe SPecTrUM of EFFects. Some are harMless while OtHErS cause life-THreAtEning coNditionS. FamiLIes of viRuses that Are includEd Are PAPOvaVirus, PolyoMavirus, ADenovirus, ANd HerPEsVirus. humAn PapiLlOma virus (hPV) is a SEriOus huMan patHoGen thaT is thOuGht to be tHe causative agent of a vast MajoriTy of dIagNosed cervIcaL CanCers, and it FallS into this cAteGorY of viRusES. AnotHer eXAmPle IS HerpEsviRUs, which, thOUgH noT USuAlly life-thrEATEniNg, can Be vERy devaStatIng.
The infection prOCess of these simIlarLY StrUctURed pRoTein-coated dsDNa viRuSES is belieVeD to be the samE within aLl VIral fAmilieS that fAll into THIs GRoup. ThE proCesS has been dIviDeD Into thrEe StAGes: adsOrptIoN to the SurfacE Of thE CEll, penetration of The ceLL MembrANe aNd traNsPort to tHE nucLeus,
, there is a cleaner or sw irl type d ust r emo vin gappa ratu s. In the clea n er,the foreign substances  whic hc an n o tbe re moved b y  t h e  re fi ni ngap p ar atuswit h the s creen plat e c an  be removedb ydifference  of  specific gr avi ty. Th er efo r e, af ter  or b eforep rocess ing the p ap e r mate r ial byt h erefi ning apparatus wi t ht he screen, the  clean er is c onn ect ed thereto  t hroug h  a pipe ,  s o t hat the dust andforeign sub s tan ces ar erem o ved co mplet el y  fr om the pape r ma terials.Howeve r , whent he clea ner is  co nne cted to  t here f ini n gapp a rat us withth escree n by t h e  pip e,it r equir es a larger i nst alla t ion  site , and  pip econne ctionbetwe en  the refining a ppar atus with  th escr ee n tot he cle ane r a t the i nstalla t ion  s i t e  t o cause cumbersome .A c co rdingly,  an ob j ec to f the pr es ent  inv e n tionis t o  p rovide a  paper ma te rial re fi ning a pp ara tus  incl u ding  a scr een plat e and a built-in cle a ner so as too bv i a te thefor egoing prob lems . 
Fur ther ob jec t s and  adva nt a ge s  of the invention w il l be a ppare nt from the f ollowing d e s c riptionof t h ei nvention. None .
Thi s inventio n  relates  to a  methodfor scree n i ng poten tia l a nti -vi r a lcompounds. In p arti cu lar, th e p resentinv ent ion  is  a n assay f or testi ng  a  c om pou nd""s abilityto  in hi bit  unco a ting o f pro tein -c oa t eddouble- s tr a n dedDN A(dsD NA)  v iruse s.
V i ral  infect ions have  pr o vento  b e espec ially challen gi ng for the  m edi cal fi e l d. So fa r, research has failedt o finda c ure f or a  viral in fec tion,and many t imes t he be st  th a t  canb e  d one  i s to relie v e  th e sym pt omsassocia ted with the illne s s.Even vaccines  ag ains t vi rus e sa reno t  to t a lly effective a t blocking  a n  i nfection.T her ef ore, at tention  hasf ocusedon stoppi ng a vira linfe c t ion  during it s initia l stageso f inf e ct ion.Thi s stop sfur therspread and  prev ents t he  infec tionfr om devel oping into a productive  disea se st ate .
Protein -co a ted  dsDNA vi ruse s make upa c las s ofvir u ses w hich ha vea  wide  spe c trum of e f fe cts . So me are harm l e s s w hileoth e rs cau se l ife-threatening c o nditions. Fami lies o f v iru s es t ha t are included  ar eP a povaviru s,  Polyomavir us, Aden ov i rus,and He rpesvi rus. Hu m a nP apillo ma V iru s (HPV) i s a  s e rious h um an pathog en t ha t is t hought to b e the causative ag ent o f a vas t  ma jorit yof diag n osed  cervicalcancers, an d it f alls  into  this c at egoryofvi ruses. Ano t her examp le is  Herpes vi rus,  wh ich, t houg h not u sual ly  li fe-threat e n in g ,ca n  be  ver y dev as tati ng.
The i n fectionpro c ess ofth ese s imilar l ys t ructured p rot ein-c o a ted dsDNAv irus e si s bel ievedto bethe sam e  wi th in allvir a l  families  that fal l  in to  thi s group.  T he p ro ces shas been divide d into t hree sta g e s: ads orp t iont o thesu rface of the  cell ,p enetrat i o n o f the c e llmem bra ne a ndtran s port to the nucleus,
, there_is a_cleaner or swirl type_dust removing_apparatus._In the_cleaner,_the foreign substances_which can not_be removed by the_refining apparatus with_the_screen plate can be removed by difference of specific gravity. Therefore, after or before_processing_the paper_material_by_the refining apparatus with the_screen, the cleaner is connected_thereto through_a pipe, so that the dust and foreign_substances_are removed completely_from the paper materials. However, when the cleaner is_connected to the refining apparatus with_the screen by_the_pipe,_it requires a larger_installation site, and pipe connection between_the refining apparatus with the screen_to the cleaner at the installation site_to cause cumbersome.
Accordingly, an object of_the present invention is to_provide a_paper material refining apparatus including_a screen plate_and a_built-in cleaner so_as to obviate the foregoing problems.
Further_objects and advantages_of the invention will be apparent_from_the following description_of_the_invention. None.
This_invention relates to_a_method for_screening_potential anti-viral compounds. In particular, the_present_invention is an assay for testing a_compound""s ability to inhibit_uncoating_of protein-coated double-stranded DNA_(dsDNA) viruses.
Viral infections have proven_to be especially challenging for the_medical field._So far,_research has failed to find a cure for a viral infection,_and many times the best that_can be done is_to relieve_the_symptoms associated with_the_illness. Even_vaccines against viruses are not totally effective_at blocking_an infection. Therefore, attention has focused_on stopping a viral_infection_during its initial stages of infection._This stops further spread and prevents_the infection from developing into_a_productive_disease state.
Protein-coated dsDNA viruses make_up a class of viruses which_have a wide_spectrum of effects. Some are harmless while_others_cause life-threatening conditions. Families of viruses_that_are included are Papovavirus, Polyomavirus, Adenovirus,_and_Herpesvirus._Human Papilloma Virus (HPV) is_a serious human pathogen that is_thought to be the causative agent of a vast_majority of diagnosed_cervical cancers, and it falls_into_this_category of viruses. Another example is Herpesvirus, which, though not_usually life-threatening,_can be very_devastating.
The infection process of these similarly structured protein-coated dsDNA viruses_is believed to be the same within_all viral families that fall into this group. The process has_been divided into three stages: adsorption to the_surface of the cell, penetration of the_cell membrane and transport_to_the nucleus,