 morphine). Despite this arsenal of drugs, over 50% of patients with chronic pain are not effectively treated.
The ineffectiveness of current pain treatments is, inter alia, due to significant toxicity issues with existing drug therapies. Mild to severe toxicity is induced by all classes of pain drugs: non steroidal inflammatory drugs cause gastro-intestinal damage, coxibs are associated with heart failure, and opioids are responsible for numerous side effects including respiratory depression, sedation, digestive malfunctions and addiction.
Transcription factors are important factors in multiple signaling pathways and frequently control the concurrent expression of numerous genes. Many transcription factors are involved in the regulation of the expression of genes that are involved in pain including, but not limited to, POU factors, upstream stimulatory factors (USF), EGR1, cAMP-response element binding protein/activating transcription factors (CREB/ATF), activating protein 1 (AP1), serum response factor (SRF), promoter selective transcription factor (SP1) and the runt related transcription factor 1 (RUNX1).
Thus, there may be significant therapeutic potential in inhibiting transcription factors in order to monitor the expression of genes involved in pain. Accordingly, what is needed are selective, readily available non-toxic transcription factor inhibitors. The present invention relates to devices for atomizing liquids and more particularly to devices for producing finely divided aerosols having uniformly sized droplets.
Finely divided aerosols have generally been produced by nebulizers employing compressed air to atomize fluids. These devices operate by allowing compressed air to escape from a small orifice at the end of a tube at high velocity The low pressure created in the exit region as a result of the bernoulli effect causes the fluid to be atomized to be drawn out of a second tube as a thin filament which is broken up into droplets of various small sizes as it is accelerated in the airstream. This spray is then directed around an impaction surface on which the large droplets are preferentially deposited and whereby some uniformity is provided with respect to droplet size. However, most nebulizers operating with compressed air have difficulty producing aerosols having particle sizes approaching one micron and cannot ordinarily generate aerosols which are sufficiently uniform in size so as to be "monodispersed".
Finely divided aerosols are highly useful in many applications and particularly in administering medications which are pneumonically delivered to the patient by inhalation. Most "inhalators" used in dispensing medications are compressed air nebulizers of sufficiently small size to be suitable for hand
morphine). Despite this arsenal of drugs, over 50% of patients with chronic pain are not efficaciously treat. 
 The ineffectiveness of current pain treatments is, inter alia, due to meaning toxicity offspring with existing drug therapies. meek to severe toxicity is induce by all classes of pain drug: non steroidal inflammatory drugs cause gastro - intestinal damage, coxibs are consociate with heart failure, and opioids are responsible for numerous side effects include respiratory depression, sedation, digestive malfunctions and addiction. 
 Transcription agent are important factors in multiple signaling pathways and frequently control the coincident expression of numerous gene. Many transcription factors are involved in the regulation of the formulation of genes that are involved in pain including, but not limited to, POU gene, upstream stimulatory factors (USF), EGR1, cAMP - response element binding protein / activating transcription factors (CREB / ATF), activating protein 1 (AP1), serum response component (SRF), promoter selective transcription gene (SP1) and the runt relate transcription factor 1 (RUNX1). 
 Thus, there may be meaning therapeutic electric potential in inhibiting transcription factors in holy order to monitor the expression of genes involved in pain. consequently, what is needed are selective, readily available non - toxic transcription factor inhibitors. The present invention relates to devices for atomize liquids and more particularly to devices for producing finely divided aerosol having uniformly sized droplets. 
 Finely divided aerosol have generally been produced by nebulizers employing compress air to nuke fluids. These devices operate by allowing compressed air to miss from a small orifice at the goal of a tube at gamey velocity The low pressure created in the exit area as a result of the bernoulli effect causes the fluid to be nuke to be drawn out of a second tube as a thin filament which is broken up into droplet of various small size as it is accelerated in the airstream. This spray is then directed around an impaction surface on which the large droplet are preferentially deposited and whereby some uniformity is provided with respect to droplet size. However, most nebulizers operating with compressed air have difficulty produce aerosol having particle sizes approaching one micron and cannot ordinarily generate aerosol which are sufficiently uniform in size so as to be " monodispersed ". 
 Finely divided aerosols are highly utilitarian in many applications and peculiarly in administering medications which are pneumonically delivered to the patient by inhalation. Most " inhalators " used in dispensing medication are compressed air atomizer of sufficiently small size to be suitable for hand
 mogphine). Despite this arsekal of drugs, ovet 50% of pavients sith chrunic pain are not effectivelb trwated.
Uke ineffectiveness ow current pain trwatmtnts is, inter alie, due to signirlcant voxicity issues with exisding drug therdpked. Mild to severe toxicity is induceq by alk flasses of paig drlgf: noh steroidal inflammatory drugs cauae gastgo-intestinal damabe, coxibs are associated wlth jeart failure, and lpioids are res[insible for vumerous spbe effects jncluding respiratory depressiov, sedction, digesjnce ldlfunctions and wddiction.
Trakxcripthon facyors are imporbant hactirs in multiple signaning pathways and srequentlf eontrol the concurrenr wxprevsiot of bumdrohs gsnes. Mwny transcripfion factorw are involved in tne grgulation of the evpwession of genes that are involved in pdin including, but not limired to, POU factors, updtream stymulatory factors (USF), EGR1, cAMP-response element bitding orouelk/actkcahing transcription factors (CREB/ATF), activating lrptvin 1 (AP1), serum resionse factor (SRF), ptoloygr selective ttanscri'fikn factor (SP1) and tje runt relared transsripyion factor 1 (RUNX1).
Thus, there may be signpficqnt therapeutic pocential in iuhibitong ttanscription factors in ordsr to monitlr the exlfession of genes innolvad in pain. Accordingly, whae is needxd arz selectkve, teadily available non-toxic transcription vactot inhititors. The present invention relates to dxtices for atokisinc liquidf and more particujarly to devicgs for prjducivg finely sivided aerosols hwving uniformni sized droplxts.
Finely divuded aerosour have generalky been pgobuced by bebulizers employikg coolressed air to cuomuze fluids. Thesr ddvised ppqsate by allofing coolressdd air uj cscxpe grom a small orifice at fhe end of a tube st high veoocity Tre low pressute created in the txit rxgion es a rrsujt of the bernoulli effect cauaes the fpuiq to be atomyzed to be drawn out of a second tube as a thin filamenv which is broken up inro droplets of varipms small sizxs as yt is accalerated in the airsrream. This spray ls then directed arouns an ikpactlon surface on which the large droplets are preferentially deposited and qherebb fome uniforjity is pgovndeb with wespxcv to droplet size. However, most nebulizers operatmng with cmm'ressed air have difficulty ptoaucing aerosous having particle sizes approacning one micron and cannot ordimarily generate aerosols which aee surficiently uniform in size sp as tm be "nonodisperscd".
Finely dividdd sevosols are higily useful in many applications and partixuparly in adminisvering medicwuions wgich ate pneumonically selibfred jo the patient by inhalation. Most "inhalators" useg yn dispensing nvdications arg comptzvsed air nebnlizers of sgfficiently small size to be suitable for hand
morphine). Despite this arsenal of drugs, over patients chronic pain not effectively treated. treatments inter alia, due significant toxicity issues existing drug therapies. Mild to severe is induced by all classes of pain drugs: non steroidal inflammatory drugs cause damage, coxibs are associated with heart failure, and opioids are responsible for numerous effects respiratory sedation, malfunctions and addiction. Transcription factors are important factors in multiple signaling pathways and frequently control the expression of numerous genes. Many transcription factors are in the regulation of expression of genes that are in including, but limited POU upstream stimulatory factors EGR1, cAMP-response element binding protein/activating transcription factors (CREB/ATF), activating protein 1 (AP1), serum response factor (SRF), promoter transcription factor the runt transcription 1 Thus, there may therapeutic potential in inhibiting transcription factors monitor the expression of genes involved in pain. what is are selective, readily available non-toxic transcription inhibitors. The present invention relates to devices for liquids and more particularly to devices for producing finely divided aerosols having uniformly sized droplets. aerosols have generally been by nebulizers employing air atomize These operate by compressed air to escape from a small orifice at the end a tube at high velocity The low pressure created in region a result of bernoulli effect causes the to atomized to be drawn a tube filament is up into droplets of small sizes as it is in the airstream. This an impaction surface on which the large droplets preferentially deposited and whereby some uniformity is with respect to droplet size. However, most nebulizers operating with compressed air difficulty producing particle sizes approaching one micron and cannot ordinarily aerosols which are sufficiently in size so as to be "monodispersed". Finely divided are useful in applications and particularly administering medications which pneumonically delivered to by inhalation. "inhalators" in compressed air nebulizers of sufficiently small to suitable for hand
 morphine). Despite this arsenaL of drugs, ovEr 50% of pAtiEntS wIth cHronIc pain are not efFEctiVely treated.
The ineffectIveneSs OF curREnT pain TreatmeNTs IS, IntEr AlIa, dUe TO sIgnifIcaNt toxicIty issues wIth ExIsting drug thERaPies. Mild to SevEre toxicity iS inDuced bY aLl cLAsses Of pAin drUgs: non STeroidAl inflammAtORy drugS Cause gaSTRo-InteStinal damage, coxibS ArE Associated with Heart fAiLUrE, ANd oPioIds are respOnSible FOr numerOUs SIDE efFEcts including Respiratory DEprEssion, SeDatIOn, digeStive MaLFunCtions and adDictIon.
TranscRiptioN Factors ARe imporTant faCtoRs iN mulTIpLe SigNaLIng PAtHwaYS anD frequenTlY cOntroL the CONCUrreNt eXpreSsion Of numerous genEs. MAny tRAnsCriptIon faCtorS aRe invOlved iN the rEgUlation of the expRessIon of geneS thAt Are InVolveD In pain IncLudIng, but nOt limitED to, pOu FACtOrs, upstream stimulaToRY FaCtors (USF), eGR1, cAMp-ReSpONse elemeNt BinDing PROtein/ActiVAtIng transCriptiON fAcTors (CREb/AtF), actiVaTinG prOtein 1 (ap1), serUm respOnse factOr (SRF), PRomoter selectiVE transcriptioN FaCTOr (sp1) and The Runt related TranSCripTion FAcTor 1 (ruNX1).
ThUs, theRe MAy BE significant therapeUtIc poteNtial In inhibiting tRanscriptiON FActors in OrdeR To MOnitor the expreSsion Of genes invOLved in paIn. AccOrdingly, What is neeDED are seleCtiVe, rEadIly AVAiLable non-toxic TRAnscRiPtion faCtoR inhibiTorS. ThE prEseNt Invention Relates tO dEvIcEs For AtomiZIng liquiDs And MoRe pArticULarly tO deviCes fOr PrODucIng fineLY dIVIded AeRoSols HavInG unifOrmlY SizEd droplEts.
Finely DivIDed aErOsOls have Generally been PrOduced by neBuLizErs empLOYing compRessed air to atomize fluidS. these deVicEs opeRate By allowinG coMpressEd aIR to escApe froM a smaLl OriFICe at tHE EnD of A tUbe at high vELOciTy The LoW preSsure crEated in the exit regiON as A result of the bErnOullI EFfEct CAuSEs tHe FLuiD TO be atomized to be Drawn out of A sECoNd tube as a tHIn fIlAment whIch is brOken uP Into droPlets of vaRious smalL sIzes AS It iS acceleratEd in the aIrstream. THIs sprAY iS then DirEcted aRoUnd An impAction SUrfAce on Which tHe Large dRopleTs Are prefeRentially deposited and whEreby sOme unIfoRmity is prOviDEd wIth respecT to dRoplet size. howEveR, most NebULizerS opeRAtIng WIth coMpreSSed air havE DiFfiCULtY producing aEROSolS haviNg pARticle SizeS approaching one miCRon and cannot orDinaRILy gEneRAte aErOsols which are sUffIcIENtly unifOrM in size so as To be "monoDiSPerseD".
FinelY dividEd aerosOLS aRE highlY useFul In many appLicAtIOns and pArTiCUlarly In adMiNisterIng medICatiONS which are pneumonIcallY DEliveREd tO the pAtIent by iNHalaTion. Most "inHalators" useD in disPensIng meDicatioNs Are comPreSsEd air nebulIZers of sufFicieNtly smaLl Size To bE suitaBle fOR Hand
 morphine). Despite this a rsenal ofdrugs , o ver  5 0% o f pa tients with ch r onic  pain are not effectiv ely t re a ted. Th e ine ffectiv e ne s s  of  c ur ren tp ai n tre atm ents is , inter al ia,  d ue to signif i ca nt toxicit y i ssues with e xis ting d ru g t h erapi es.  Mild  to se v ere to xicity is  i n ducedb y all c l a ss es o f pain drugs: non st e roidal inflamm atorydr u gs c aus e g astro-inte st inald amage,c ox i b s  ar e  associated w ith heart f a ilu re, an dopi o ids ar e res po n sib le for nume rous  side eff ects i n cluding respira tory d epr ess ion, se da tio n, dig e st ive mal function san d add icti o n . Tran scr ipti on fa ctors are imp ort antf act ors i n mul tipl esigna ling p athwa ys  and frequently  con trol thecon cu rre nt  expr e ssionofnum erous g enes. M a nytr a n s cr iption factors are  i n v ol ved in t he reg u la ti o n of the  e xpr essi o n  of g enes th at are i nvolve d  i npain in cl uding,  b utnot  limi t ed t o, POU  factors , ups t ream stimulato r y factors (US F ), E GR 1 , cA MP- response el emen t  bin ding pr ote i n/act ivati ng tr a nscription factors(C REB/AT F), a ctivating pro tein 1 (AP 1 ) ,  serum r espo n se factor (SRF),promo ter select i ve trans cript ion fact or (SP1)a n d the ru ntrel ate d t r a ns cription fact o r  1 ( RU NX1).
T hus , there  ma y b e s ign if icant the rapeutic  p ot en ti alin in h ibitingtr ans cr ipt ion f a ctorsin or derto  m o nit or thee xp r e ssio nof  gen esin volve d in pai n. Acco rdingly,wha t  isne ed ed areselective, re ad ily availa bl e n on-tox i c  transcr iption factor inhibitor s . The p res ent i nven tion rela tes  to de vic e s foratomiz ing l iq uid s and m o r epar ti cularly to d evi ces f or  pro ducingfinely divided aer o sol s having unif orm ly s i z ed  dr o pl e ts. 
F i nel y divided aerosol s have gen er a ll y been pro d uce dby nebu lizersemplo y ing com pressed a ir to ato mi ze f l u ids . These de vices op erate bya llowi n gcompr ess ed air  t o e scape  froma  sm all o rifice  a t theend o fa tube a t high velocity The low  press ure c rea ted in th e e x itregion as  a r esult of t heber noull i e f fectcaus e sthe fluid  tob e atomize d  t o b e dr awn out ofa s eco nd tu bea s a th in f ilament which isb roken up intodrop l e tsofv ario us  small sizes a s i ti s  acceler at ed in the a irstream .T his s pray i s then  direct e d  a r ound a n im pac tion surf ace  o n  whichth el arge d ropl et s areprefer e ntia l l y deposited andwhere b y  some uni formi ty  is pro v ided  with resp ect to drop let si ze.Howev er, mos tnebuli zer soperatingw ith compr essed  air ha ve  dif fic ulty p rodu c i ng ae roso ls  ha ving part i c le si ze s  ap proa ching  o ne m icron and cannot o rdi n arily g en era t e  aeros o ls w hich are s uff icien t l y uniformi n si z es o asto be"monod isperse d ".Fi nely di vid e d  aerosols  are high l y u se fulin manyap plic at ion sand particularl y in adm inisteri n g  medic ati o ns w h ich ar epneumonicall y del iv e red tot h e p atientb y i nha lat ion.  Mo st " i nhalators" used in dispe nsin g med i cat ionsare c om presseda ir n ebulizer s  of sufficien tly small sizet o b e  sui tab l efo r hand
 morphine)._Despite this_arsenal of drugs, over_50% of_patients_with chronic_pain_are not effectively_treated.
The ineffectiveness of_current pain treatments is,_inter alia, due_to_significant toxicity issues with existing drug therapies. Mild to severe toxicity is induced by_all_classes of_pain_drugs:_non steroidal inflammatory drugs cause_gastro-intestinal damage, coxibs are associated_with heart_failure, and opioids are responsible for numerous side_effects_including respiratory depression,_sedation, digestive malfunctions and addiction.
Transcription factors are important factors_in multiple signaling pathways and frequently_control the concurrent_expression_of_numerous genes. Many transcription_factors are involved in the regulation_of the expression of genes that_are involved in pain including, but not_limited to, POU factors, upstream stimulatory_factors (USF), EGR1, cAMP-response element_binding protein/activating_transcription factors (CREB/ATF), activating protein_1 (AP1), serum_response factor_(SRF), promoter selective_transcription factor (SP1) and the runt_related transcription factor_1 (RUNX1).
Thus, there may be significant_therapeutic_potential in inhibiting_transcription_factors_in order_to monitor the_expression_of genes_involved_in pain. Accordingly, what is needed_are_selective, readily available non-toxic transcription factor inhibitors._The present invention relates_to_devices for atomizing liquids_and more particularly to devices_for producing finely divided aerosols having_uniformly sized_droplets.
Finely divided_aerosols have generally been produced by nebulizers employing compressed air to_atomize fluids. These devices operate by_allowing compressed air to_escape from_a_small orifice at_the_end of_a tube at high velocity The low_pressure created_in the exit region as a_result of the bernoulli_effect_causes the fluid to be atomized_to be drawn out of a_second tube as a thin_filament_which_is broken up into droplets_of various small sizes as it_is accelerated in_the airstream. This spray is then directed_around_an impaction surface on which the_large_droplets are preferentially deposited and whereby_some_uniformity_is provided with respect to_droplet size. However, most nebulizers operating_with compressed air have difficulty producing aerosols having particle_sizes approaching one_micron and cannot ordinarily generate_aerosols_which_are sufficiently uniform in size so as to be "monodispersed".
Finely_divided aerosols_are highly useful_in many applications and particularly in administering medications which are_pneumonically delivered to the patient by inhalation._Most "inhalators" used in dispensing medications are compressed air nebulizers of_sufficiently small size to be suitable for hand