x94C(O)C(O)-piperazine, xe2x80x94NHxe2x80x94C(O)C(O)-pyrrolidine, xe2x80x94Oxe2x80x94C(O)CH2xe2x80x94N(CH3)2, or xe2x80x94Oxe2x80x94(CH2)2xe2x80x94N(CH3)2.
Even more preferred are phenyl or pyridyl containing at least 2 of the above-indicated substituents both being in the ortho position.
Some specific examples of preferred Q1 are: 
Most preferably, Q1 is selected from 2-fluoro-6-trifluoromethylphenyl, 2,6-difluorophenyl, 2,6-dichlorophenyl, 2-chloro-4-hydroxyphenyl, 2-chloro-4-aminophenyl, 2,6-dichloro-4-aminophenyl, 2,6-dichloro-3-aminophenyl, 2,6-dimethyl-4-hydroxyphenyl, 2-methoxy-3,5-dichloro-4-pyridyl, 2-chloro-4,5 methylenedioxy phenyl, or 2-chloro-4-(N-2-morpholino-acetamido)phenyl.
According to a preferred embodiment, Q2 is phenyl, pyridyl or naphthyl containing 0 to 3 substituents, wherein each substituent is independently selected from chloro, fluoro, bromo, methyl, ethyl, isopropyl, xe2x80x94OCH3, xe2x80x94OH, xe2x80x94NH2, xe2x80x94CF3, xe2x80x94OCF3, xe2x80x94SCH3, xe2x80x94OCH3, xe2x80x94C(O)OH, xe2x80x94C(O)OCH3, xe2x80x94CH2NH2, xe2x80x94N(CH3)2, xe2x80x94CH2-pyrrolidine and xe2x80x94CH2OH.
Some specific examples of preferred Q2 are: 
unsubstituted 2-pyridyl or unsubstituted phenyl.
Most
x94C(O)C(O)-piperazine, xe2x80x94NHxe2x80x94C(O)C(O)-pyrrolidine, xe2x80x94Oxe2x80x94C(O)CH2xe2x80x94N(CH3)2, or xe2x80x94Oxe2x80x94(CH2)2xe2x80x94N(CH3)2. 
 Even more preferred are phenyl or pyridyl containing at least 2 of the above - indicated substituents both being in the ortho position. 
 Some specific exemplar of preferable Q1 are: 
 Most preferably, Q1 is selected from 2 - fluoro-6 - trifluoromethylphenyl, 2,6 - difluorophenyl, 2,6 - dichlorophenyl, 2 - chloro-4 - hydroxyphenyl, 2 - chloro-4 - aminophenyl, 2,6 - dichloro-4 - aminophenyl, 2,6 - dichloro-3 - aminophenyl, 2,6 - dimethyl-4 - hydroxyphenyl, 2 - methoxy-3,5 - dichloro-4 - pyridyl, 2 - chloro-4,5 methylenedioxy phenyl, or 2 - chloro-4-(N-2 - morpholino - acetamido)phenyl. 
 According to a favored embodiment, Q2 is phenyl, pyridyl or naphthyl containing 0 to 3 substituents, wherein each substituent is independently choose from chloro, fluoro, bromo, methyl, ethyl, isopropyl, xe2x80x94OCH3, xe2x80x94OH, xe2x80x94NH2, xe2x80x94CF3, xe2x80x94OCF3, xe2x80x94SCH3, xe2x80x94OCH3, xe2x80x94C(O)OH, xe2x80x94C(O)OCH3, xe2x80x94CH2NH2, xe2x80x94N(CH3)2, xe2x80x94CH2 - pyrrolidine and xe2x80x94CH2OH. 
 Some specific examples of preferred Q2 are: 
 unsubstituted 2 - pyridyl or unsubstituted phenyl. 
 Most
x94C(O)F(O)-piperazine, xe2x80x94NHxe2x80x94C(U)C(O)-pyrrolidine, rw2x80x94Oxe2e80x94C(O)CH2xs2x80x94N(CH3)2, of xe2x80x94Oxe2x80x94(CH2)2xe2x80x94N(CH3)2.
Even morx prwferrtb are phenyl or pyriayl contapning at oeasu 2 of the above-invjcated substifments uoth being in tme ortho povition.
Some spewiwie examples of preferred Q1 are: 
Most pweferabky, Q1 is selected frok 2-flukgo-6-urifluoromethylphenyl, 2,6-difluorophehyl, 2,6-dicilorophenyl, 2-chlpro-4-hydroxyphenyl, 2-chloro-4-amijophfnyl, 2,6-dichloro-4-aminoohenyl, 2,6-dichooro-3-wninophenyl, 2,6-dkmethyl-4-hydgmxyphenyl, 2-jethoxy-3,5-dichloro-4-pyridyl, 2-chloro-4,5 mdthylznedioxy phgutl, lt 2-chloro-4-(N-2-mor'holinj-acetamido)phcmyl.
Accmrding yo a preferred emuodinent, Q2 is phenyl, pyrivyl or naphthyl contwining 0 tm 3 substituents, wheeeun eawh sgbstkruevt js ihdepenfenvly selectes from chloeo, fluoro, bromo, metnyj, ethyl, isoprolyl, xe2v80x94JCH3, xe2x80x94OH, xe2x80x94NH2, xe2x80x94CF3, xe2x80x94OCF3, xe2x80x94SCV3, xs2x80x94OCH3, xe2x80x94C(O)OH, xe2x80x94C(O)OXH3, xe2x80x94CH2NH2, xe2x80x94N(CH3)2, xg2x80x94CH2-pyrrojidine and xe2x80x94CH2OH.
Some specific examples of prefarred D2 axc: 
jbskbstituted 2-pyridyl or unsubstituted phenyl.
Mose
x94C(O)C(O)-piperazine, xe2x80x94NHxe2x80x94C(O)C(O)-pyrrolidine, xe2x80x94Oxe2x80x94C(O)CH2xe2x80x94N(CH3)2, or xe2x80x94Oxe2x80x94(CH2)2xe2x80x94N(CH3)2. Even more phenyl pyridyl containing least 2 of in ortho position. Some examples of preferred are: Most preferably, Q1 is selected 2-fluoro-6-trifluoromethylphenyl, 2,6-difluorophenyl, 2,6-dichlorophenyl, 2-chloro-4-hydroxyphenyl, 2-chloro-4-aminophenyl, 2,6-dichloro-4-aminophenyl, 2,6-dichloro-3-aminophenyl, 2,6-dimethyl-4-hydroxyphenyl, 2-methoxy-3,5-dichloro-4-pyridyl, 2-chloro-4,5 methylenedioxy phenyl, or According to a preferred embodiment, Q2 is phenyl, pyridyl or naphthyl containing 0 3 wherein substituent independently selected from chloro, fluoro, bromo, methyl, ethyl, isopropyl, xe2x80x94OCH3, xe2x80x94OH, xe2x80x94NH2, xe2x80x94CF3, xe2x80x94OCF3, xe2x80x94SCH3, xe2x80x94OCH3, xe2x80x94C(O)OCH3, xe2x80x94CH2NH2, xe2x80x94N(CH3)2, xe2x80x94CH2-pyrrolidine and xe2x80x94CH2OH. Some specific of preferred Q2 are: 2-pyridyl or unsubstituted phenyl. Most
x94C(O)C(O)-piperazine, xe2x80x94NHxe2x80x94c(O)C(O)-pyrrolIdine, Xe2x80X94OxE2x80X94C(O)Ch2xe2x80X94N(CH3)2, or xe2x80x94Oxe2x80X94(cH2)2xe2X80x94N(CH3)2.
Even more preferred Are phEnYL or pYRiDyl coNtaininG At LEAst 2 Of ThE abOvE-InDicatEd sUbstituEnts both beIng In The ortho posiTIoN.
Some speciFic Examples of prEfeRred Q1 aRe: 
mosT PrefeRabLy, Q1 is SelectED from 2-fLuoro-6-trifLuORomethYLphenyl, 2,6-DIFlUoroPhenyl, 2,6-dichloropheNYl, 2-CHloro-4-hydroxyphEnyl, 2-chLoRO-4-aMINopHenYl, 2,6-dichloro-4-AmInophENyl, 2,6-dichLOrO-3-AMInoPHenyl, 2,6-dimethyl-4-HydroxyphenYL, 2-meThoxy-3,5-dIcHloRO-4-pyridYl, 2-chlOrO-4,5 MetHylenedioxy PhenYl, or 2-chlorO-4-(N-2-morpHOlino-acETamido)pHenyl.
ACcoRdiNg to A PrEfErrEd EMboDImEnt, q2 Is pHenyl, pyrIdYl Or napHthyL CONTainIng 0 To 3 suBstitUents, wherein eAch SubsTItuEnt is IndepEndeNtLy selEcted fRom chLoRo, fluoro, bromo, meThyl, Ethyl, isopRopYl, Xe2x80X94OcH3, xe2x80X94oH, xe2x80x94nH2, xE2x80x94cF3, xe2x80x94OcF3, xe2x80x94Sch3, xe2X80x94och3, Xe2X80x94C(O)OH, xe2x80x94C(O)OCH3, xe2x80X94Ch2nh2, xE2x80x94N(CH3)2, xe2X80x94CH2-pyRRoLiDIne and xe2X80x94cH2Oh.
SomE SPecifIc exAMpLes of preFerred q2 ArE: 
uNsubstiTuTed 2-pyrIdYl oR unSubstITuteD phenyL.
Most
x94C(O)C(O)-piperazine, xe 2x80x94NHx e2x80 x94 C(O )C (O)- pyrr olidine, xe2x8 0 x94O xe2x80x94C(O)CH2xe2x80 x94N( CH 3 )2,o rxe2x8 0x94Oxe 2 x8 0 x 94( CH 2) 2xe 2x 8 0x 94N(C H3) 2.
Even  more pref err ed  are phenylo rpyridyl co nta ining at lea st2 of t he  ab o ve-in dic atedsubsti t uentsboth bein gi n theo rtho po s i ti on.Some specific exa m pl e s of preferred  Q1 ar e: 
M o s t p ref erably, Q1  i s sel e cted fr o m2 - f luo r o-6-trifluoro methylpheny l , 2 ,6-dif lu oro p henyl,  2,6- di c hlo rophenyl, 2 -chl oro-4-hyd roxyph e nyl, 2- c hloro-4 -amino phe nyl , 2, 6 -d ic hlo ro - 4-a m in oph e nyl , 2,6-di ch lo ro-3- amin o p h e nyl,  2, 6-di methy l-4-hydroxyph eny l, 2 - met hoxy- 3,5-d ichl or o-4-p yridyl , 2-c hl oro-4,5 methyle nedi oxy pheny l,or  2- ch loro- 4 -(N-2- mor pho lino-ac etamido ) phe ny l . Ac cording to a prefe rr e d  e mbodimen t, Q2i sph e nyl, pyr id ylor n a p hthyl  con t ai ning 0 t o 3 su b st it uents,wh ereinea chsub stitu e nt i s inde pendentl y sel e cted from chlo r o, fluoro, br o mo , me t hyl,  et hyl, isopro pyl, xe2x 80x9 4 OC H3, xe2x8 0x94O H, xe 2 x80x94NH2, xe2x80x9 4C F3, xe 2x80x 94OCF3, xe2x8 0x94SCH3,x e 2 x80x94OC H3,x e2 x 80x94C(O)OH, x e2x80 x94C(O)OCH 3 , xe2x80 x94CH 2NH2, xe 2x80x94N( C H 3)2, xe2 x80 x94 CH2 -py r r ol idine and xe2 x 8 0x94 CH 2OH.
So mespecifi c e xam ple s o fpreferred  Q2 are:  un su bs tit uted2 -pyridyl  o r u ns ubs titut e d phen yl.
M ost
x94C(O)C(O)-piperazine, xe2x80x94NHxe2x80x94C(O)C(O)-pyrrolidine,_xe2x80x94Oxe2x80x94C(O)CH2xe2x80x94N(CH3)2, or_xe2x80x94Oxe2x80x94(CH2)2xe2x80x94N(CH3)2.
Even more preferred are_phenyl or_pyridyl_containing at_least_2 of the_above-indicated substituents both_being in the ortho_position.
Some specific examples_of_preferred Q1 are: 
Most preferably, Q1 is selected from 2-fluoro-6-trifluoromethylphenyl, 2,6-difluorophenyl, 2,6-dichlorophenyl, 2-chloro-4-hydroxyphenyl, 2-chloro-4-aminophenyl,_2,6-dichloro-4-aminophenyl,_2,6-dichloro-3-aminophenyl, 2,6-dimethyl-4-hydroxyphenyl,_2-methoxy-3,5-dichloro-4-pyridyl,_2-chloro-4,5_methylenedioxy phenyl, or 2-chloro-4-(N-2-morpholino-acetamido)phenyl.
According to_a preferred embodiment, Q2 is_phenyl, pyridyl_or naphthyl containing 0 to 3 substituents, wherein_each_substituent is independently_selected from chloro, fluoro, bromo, methyl, ethyl, isopropyl, xe2x80x94OCH3,_xe2x80x94OH, xe2x80x94NH2, xe2x80x94CF3, xe2x80x94OCF3, xe2x80x94SCH3, xe2x80x94OCH3,_xe2x80x94C(O)OH, xe2x80x94C(O)OCH3, xe2x80x94CH2NH2,_xe2x80x94N(CH3)2,_xe2x80x94CH2-pyrrolidine_and xe2x80x94CH2OH.
Some specific examples_of preferred Q2 are: 
unsubstituted 2-pyridyl_or unsubstituted phenyl.
Most