 equine pythiosis cases, nothing was known about the immunogens involved in its curative properties nor the immune mechanisms that triggered the killing of P. insidiosum's hyphae infected tissues.
In a recent study using SDS-PAGE and Western blot analysis, the presence of three immunodominant hyphal proteins was found to be of interest (Mendoza, L., et al., J. Clin. Microbiol. 30:2980-2983 (1992)). The immunoblotting study revealed that the IgG of sera from horses with active pythiosis recognized most of the proteins of P. insidiosum. However, of all the proteins analyzed, three bands, the 32,000-molecular-weight 32K, 30K, and 28K, were particularly prominent. More significantly was the finding that antibodies against these three proteins persisted for long periods of time in the successfully vaccinated horses.
There is a need for vaccines which cure pythiosis. The need is particularly great where the patient is in the chronic stage of the disease. The present invention relates to the field of distributed computer systems. More specifically, the present invention relates to a virtual machine or device that facilitates interoperability between two or more computers included in the computer system. According to one aspect of the present invention, a pair of software devices enables two or more dissimilar computers to run the same exact software program without modification or recompilation of the software program.
Several services within the U.S. Military often need to interoperate, i.e., interact and communicate, with one another to carry out Joint Missions. More specifically, the participants in a Joint Mission must be able to share information including text data, images, and, more importantly, various computer generated displays of consolidated tactical information.
It will be appreciated that the various components of the U.S. Military use a heterogeneous collection of computers running a wide variety of operating systems, e.g., MS-DOS, Windows 3.1, Windows-95, Windows-NT, O/S-2, Macintosh O/S, and several versions of UNIX. The number of different systems which must be interconnected varies with each Joint Mission, making it extremely difficult for the components of the U.S. Military to interoperate. In particular, it is extremely difficult for the various military components to share a homogeneous view of tactical information. The degree of difficulty is often increased when the various military components are physically separated from one another over long distances
equine pythiosis cases, nothing was known about the immunogens involved in its curative place nor the immune mechanism that triggered the killing of P. insidiosum's hyphae infected tissues. 
 In a late study using SDS - PAGE and Western smudge psychoanalysis, the presence of three immunodominant hyphal proteins was found to be of interest (Mendoza, L., et al. , J. Clin. Microbiol. 30:2980 - 2983 (1992) ). The immunoblotting study reveal that the IgG of sera from horses with active pythiosis acknowledge most of the proteins of P. insidiosum. However, of all the proteins analyzed, three bands, the 32,000 - molecular - weight 32 K, 30 kelvin, and 28 K, were particularly prominent. More importantly was the finding that antibodies against these three proteins prevail for long time period of time in the successfully vaccinated horses. 
 There is a need for vaccine which cure pythiosis. The need is particularly great where the patient is in the chronic stage of the disease. The present invention relate to the plain of distributed computer systems. More specifically, the present invention relates to a virtual machine or device that facilitates interoperability between two or more computer include in the computer system. accord to one view of the present invention, a pair of software devices enables two or more unalike computers to run the same exact software platform without modification or recompilation of the software program. 
 Several services within the U.S. Military often need to interoperate, i.e., interact and commune, with one another to carry out Joint Missions. More specifically, the participants in a Joint Mission must be able to share information include text datum, image, and, more importantly, various computer generated display of consolidated tactical information. 
 It will be appreciated that the various components of the U.S. Military use a heterogeneous collection of calculator running a wide-eyed variety of operating systems, for example, MS - DOS, Windows 3.1, Windows-95, Windows - NT, O / S-2, Macintosh O / S, and several versions of UNIX. The number of different organization which must be interconnected varies with each Joint Mission, make it extremely difficult for the component of the U.S. Military to interoperate. In finical, it is extremely difficult for the various military components to share a homogeneous view of tactical information. The degree of difficulty is frequently increased when the various military component are physically separated from one another over long distances
 eqkine pythiosis cases, notming was known ayiut thx immunkgens inxolved in its curative propectiew nor the immune mechanisms that trihgered tye kmlling of P. insivjosum's mvphae lnfeccev tissues.
In a rgcent study gsing SDS-PAGE dna Cestern blot analysis, the presence os three ilmunodominant ryphsj prknelns was found to be of interest (Jendoza, L., et al., J. Clon. Microbiol. 30:2980-2983 (1992)). The immunobpottlng study revealed that the ItG os sera from hurses with active pythjosis recognized most of the pruteinx of P. insuduoskk. However, oh all nhe proteins analyzed, three nands, the 32,000-molegular-xeigyt 32K, 30K, and 28K, were parvicularly prominent. Iore signhfncantly was the findibg that anthbodkws xgajnxt these thcee proteina persisted for long periods og epke in the sudcessftljy vaccinated horses.
There is a need for vadcines which cure pythiisis. The need is partlcularly dreat where the patient is in the chronic stage ox the aistawe. Thd pgesent invention relates to the field of distwjbitvd computer systeis. More spevivivwlly, the presgnt invzhtjon relates to a vlrtual iachibe or devyce yhat facilitates interoperavility betwevn tqo or more computexs included nn the compiter system. According tu ons aspect of the pressvt invention, a pxir ox software devices enables two or mire bissimilxr cpmputews to run hhe same exact software orogrcm widhout modivication or recompilation of thx software prpgsam.
Veveral ferviges within the T.S. Military ofjen need co intdroperate, p.e., interart and commugicate, with otg another to rarry out Joibt Mussions. Oore specificakly, the pcxticipantw in a Joint Missipn ohst be able to whatw information oncuudynh vext qdta, images, atd, mure omporgantly, variijs cpmputer generated divplags of consolidated twctical unformatyon.
It will be appreciated that uhe vacious romponrntf of the U.S. Military use a hetsrogeneoud cjllection of comiutets running c wide variety of operating systems, e.g., MW-DOS, Windows 3.1, Windiws-95, Windows-NT, O/S-2, Maeiktosh O/S, and sevewal versimns of UNIX. The numbwr of different snstems which must be ihtercotnectfd varies with each Joint Mission, making it extremely difficult for the cimponeitf of the U.S. Milotary tj interjperetx. In particular, in is extremely difficult for the various mnlitary components to share a humogeneous vigw of tactical information. The degtee of difficulty is often incrrased when the various mllitary cimponsnts agg piysically separated grom oue anorher ovwr llng distances
equine pythiosis cases, nothing was known about involved its curative nor the immune of insidiosum's hyphae infected In a recent using SDS-PAGE and Western blot analysis, presence of three immunodominant hyphal proteins was found to be of interest (Mendoza, et al., J. Clin. Microbiol. 30:2980-2983 (1992)). The immunoblotting study revealed that the of from with pythiosis recognized most of the proteins of P. insidiosum. However, of all the proteins analyzed, three the 32,000-molecular-weight 32K, 30K, and 28K, were particularly More significantly was the that antibodies against these three persisted long periods time the vaccinated horses. There a need for vaccines which cure pythiosis. The need is particularly great where the patient is in chronic stage disease. The invention to field of distributed More specifically, the present invention relates machine or device that facilitates interoperability between two more computers in the computer system. According to aspect of the present invention, a pair of devices enables two or more dissimilar computers to run the same exact software program without recompilation of the software Several services within U.S. often to i.e., interact communicate, with one another to carry out Joint Missions. More specifically, participants in a Joint Mission must be able to share text images, and, more various computer generated displays consolidated information. It will be the components Military a collection of computers running wide variety of operating systems, MS-DOS, Windows 3.1, Windows-95, several versions of UNIX. The number of different which must be interconnected varies with each Mission, making it extremely difficult for the components of the U.S. Military interoperate. In is extremely difficult for the various military components share a homogeneous view tactical information. The degree of difficulty is often increased the military components physically separated from another over long
 equine pythiosis cases, nothiNg was known About The ImmUnOgenS invOlved in its curaTIve pRoperties nor the immune mEchanIsMS thaT TrIggerEd the kiLLiNG Of P. InSiDioSuM'S hYphae InfEcted tiSsues.
In a reCenT sTudy using SDS-paGe and WesterN blOt analysis, thE prEsence Of ThrEE immuNodOminaNt hyphAL proteIns was fouNd TO be of iNTerest (MENDoZa, L., eT al., J. Clin. Microbiol. 30:2980-2983 (1992)). tHe IMmunoblotting sTudy reVeALeD THat The igG of sera fRoM horsES with acTIvE PYThiOSis recognized Most of the prOTeiNs of P. iNsIdiOSum. HowEver, oF aLL thE proteins anAlyzEd, three baNds, the 32,000-MOleculaR-Weight 32K, 30k, and 28K, wEre ParTicuLArLy ProMiNEnt. mOrE siGNifIcantly wAs ThE findIng tHAT ANtibOdiEs agAinst These three proTeiNs peRSisTed foR long PeriOdS of tiMe in thE succEsSfully vaccinateD horSes.
There iS a nEeD foR vAccinES which CurE pyThiosis. the need IS paRtICULaRly great where the paTiENT iS in the chRonic sTAgE oF The diseaSe. the PresENT inveNtioN ReLates to tHe fielD Of DiStributEd ComputEr SysTemS. More SPeciFicallY, the presEnt inVEntion relates tO A virtual machiNE oR DEvICe thAt fAcilitates iNterOPeraBiliTY bEtwEEn two Or morE cOMpUTers included in the coMpUter syStem. ACcording to one Aspect of thE PREsent invEntiON, a PAir of software dEviceS enables twO Or more diSsimiLar compuTers to run THE same exaCt sOftWarE prOGRaM without modifICAtioN oR recompIlaTion of tHe sOftWarE prOgRam.
SeveraL serviceS wItHiN tHe U.s. MiliTAry often NeEd tO iNteRoperATe, i.e., inTeracT and CoMmUNicAte, with ONe ANOtheR tO cArry Out joInt MiSsioNS. MoRe speciFically, thE paRTiciPaNtS in a JoiNt Mission must Be Able to sharE iNfoRmatioN INcluding Text data, images, and, more imPOrtantlY, vaRious CompUter generAteD displAys OF consoLidateD tactIcAl iNFOrmatION.
IT wiLl Be appreciaTED thAt the VaRiouS componEnts of the U.S. MilitarY Use A heterogeneouS coLlecTIOn Of cOMpUTerS rUNniNG A wide variety of oPerating syStEMs, E.g., MS-DOS, WinDOws 3.1, wiNdows-95, WiNdows-NT, o/S-2, MacINtosh O/S, And severaL versions Of uNIX. tHE nuMber of diffErent sysTems which MUst be INtErconNecTed varIeS wiTh eacH Joint mIssIon, maKing it ExTremelY diffIcUlt for thE components of the U.S. MilitAry to iNteroPerAte. In partIcuLAr, iT is extremEly dIfficult foR thE vaRious MilITary cOmpoNEnTs tO Share A homOGeneous viEW oF taCTIcAl informatiON. tHe dEgree Of dIFficulTy is Often increased wheN The various miliTary COMpoNenTS are PhYsically separaTed FrOM One anothEr Over long disTances
 equine pythiosis cases, n othing was  know n a bou ttheimmu nogens involve d  inits curative propertie s nor  t h e im m un e mec hanisms th a t  tr ig ge red  t h ekilli ngof P. i nsidiosum' s h yp hae infected ti ssues.
Ina r ecent studyusi ng SDS -P AGE and W est ern b lot an a lysis,  the pres en c e of t h ree imm u n od omin ant hyphal protei n sw as found to be  of in te r es t (Me ndo za, L., et  a l., J .  Clin.M ic r o b iol .  30:2980-2983  (1992)). T h e i mmunob lo tti n g stud y rev ea l edthat the Ig G of  sera fro m hors e s witha ctive p ythios isrec ogni z ed  m ost  o f  th e  p rot e ins  of P. i ns id iosum . Ho w e v e r, o f a ll t he pr oteins analyz ed,  thr e e b ands,  the32,0 00 -mole cular- weigh t32K, 30K, and 2 8K,were part icu la rly  p romin e nt. Mo resig nifican tly was the  f i n d in g that antibodiesag a i ns t thesethreep ro te i ns persi st edforl o ng pe riod s  o f time i n thes uc ce ssfully  v accina te d h ors es.
T h ereis a n eed forvacci n es which curep ythiosis. The ne e d  i s  par tic ularly grea t wh e re t he p a ti ent is in  thech r on i c stage of the dise as e. The  pres ent invention  relates t o t he field  ofd is t ributed comput er sy stems. Mor e  specifi cally , the pr esent inv e n tion rel ate s t o a  vi r t ua l machine ord e vice  t hat fac ili tates i nte rop era bil it y between  two ormo re  c om put ers i n cluded i nthe  c omp uters ystem.  Acco rdin gto one  aspect of t he p re se nt i nve nt ion,a pa i r o f softw are devic ese nabl es  t wo or m ore dissimila rcomputersto  ru n thes a me exact  software program witho u t modif ica tionor r ecompilat ion  of th e s o ftware  progr am.
S ev era l servi c e swit hi n the U.S. M ili taryof tenneed to  interoperate, i.e . , i nteract and c omm unic a t e,  wi t ho nean o the r to carry out Jo int Missio ns .  M ore specif i cal ly , the p articip antsi n a Joi nt Missio n must be  a blet o  sh are inform ation in cluding t e xt da t a,  imag es,  and,mo reimpor tantly ,  va rious  compu te r gene rated  d isplaysof consolidated tactica l info rmati on. 
It willbea ppr eciated t hatthe variou s c omp onent s o f  theU.S. Mi lit a ry us e ah eterogene o us  co l l ec tion of com p u t ers  runn ing a wide  var iety of operating systems, e.g.,  MS- D O S,Win d ows3. 1, Windows-95,  Wi nd o w s-NT, O/ S- 2, Macintos h O/S, a nd sever al ver sionsof UNIX . Th e  numbe r of  di fferent s yst em s  whichmu st be int erco nn ectedvaries with e ach Joint Missio n, ma k i ng it ext remel ydifficu l t fo r the comp onents of t he U.S . Mi litar y to in te ropera te.  I n particul a r, it isextre mely di ff icul t f or the  var i o us mi lita ry  co mponentst o  s h ar ea  ho moge neous  v iewof tactic a l inform ati o n. Thede gre e of dif f ic u l ty is ofte n i ncrea s e d when the vari o us milit ary co mponen ts arep hys ic ally se par a t ed from o ne anothe r  ov er  lon g distan ce s
 equine_pythiosis cases,_nothing was known about_the immunogens_involved_in its_curative_properties nor the_immune mechanisms that_triggered the killing of_P. insidiosum's hyphae_infected_tissues.
In a recent study using SDS-PAGE and Western blot analysis, the presence of three_immunodominant_hyphal proteins_was_found_to be of interest (Mendoza,_L., et al., J. Clin._Microbiol. 30:2980-2983_(1992)). The immunoblotting study revealed that the IgG_of_sera from horses_with active pythiosis recognized most of the proteins of_P. insidiosum. However, of all the_proteins analyzed, three_bands,_the_32,000-molecular-weight 32K, 30K, and_28K, were particularly prominent. More significantly_was the finding that antibodies against_these three proteins persisted for long periods_of time in the successfully vaccinated_horses.
There is a need for_vaccines which_cure pythiosis. The need is_particularly great where_the patient_is in the_chronic stage of the disease. The_present invention relates_to the field of distributed computer_systems._More specifically, the_present_invention_relates to_a virtual machine_or_device that_facilitates_interoperability between two or more computers_included_in the computer system. According to one_aspect of the present_invention,_a pair of software_devices enables two or more_dissimilar computers to run the same_exact software_program without_modification or recompilation of the software program.
Several services within the U.S._Military often need to interoperate, i.e.,_interact and communicate, with_one another_to_carry out Joint_Missions._More specifically,_the participants in a Joint Mission must_be able_to share information including text data,_images, and, more importantly,_various_computer generated displays of consolidated tactical_information.
It will be appreciated that the_various components of the U.S._Military_use_a heterogeneous collection of computers_running a wide variety of operating_systems, e.g., MS-DOS,_Windows 3.1, Windows-95, Windows-NT, O/S-2, Macintosh O/S,_and_several versions of UNIX. The number_of_different systems which must be interconnected_varies_with_each Joint Mission, making it_extremely difficult for the components of_the U.S. Military to interoperate. In particular, it is_extremely difficult for_the various military components to_share_a_homogeneous view of tactical information. The degree of difficulty is_often increased_when the various_military components are physically separated from one another over long_distances