 wherein Cy is optionally substituted with one to four substituents independently selected from Rc; where Cy, Rc, Rd, Re, Rf, Rg, Rh, m and n are as defined herein;
R4 is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, thiocarbonyl-amino, acyloxy, amino, amidino, alkyl amidino, thioamidino, aminoacyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aryl, substituted aryl, aryloxy, substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, cyano, halogen, hydroxyl, nitro, oxo, carboxyl, carboxylalkyl, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl, carboxyl-substituted aryl, carboxylheteroaryl, carboxyl-substituted heteroaryl, carboxylheterocyclic, carboxyl-substituted heterocyclic, cycloalkyl, substituted cycloalkyl, guanidino, guanidinosulfone, thiol, thioalkyl, substituted thioalkyl, thioaryl, substituted thioaryl, thiocycloalkyl, substituted thiocycloalkyl, thioheteroaryl, substituted thioheteroaryl, thioheterocyclic, substituted thioheterocyclic, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, oxycarbonylamino, oxythiocarbonylamino, xe2x80x94OS(O)2-alkyl, xe2x80x94OS(O)2-substituted alkyl, xe2x80x94OS(O)2-aryl, xe2x80x94OS(O)2-substituted aryl, xe2x80x94OS(O)2-heteroaryl, xe2x80x94OS(O)2-substituted heteroaryl, xe2x80x94OS(O)2-heterocyclic, xe2x80x94OS(O)2-substituted heterocyclic, xe2x80x94OSO2xe2x80x94NRR where each R is independently hydrogen or alkyl, xe2x80x94NRS(O)2-alkyl, xe
wherein Cy is optionally substituted with one to four substituents independently selected from Rc; where Cy, Rc, Rd, Re, Rf, Rg, Rh, m and n are as defined herein; 
 R4 is choose from the group consist of alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, thiocarbonyl - amino, acyloxy, amino, amidino, alkyl amidino, thioamidino, aminoacyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aryl, substituted aryl, aryloxy, substitute aryloxy, aryloxyaryl, substituted aryloxyaryl, cyano, halogen, hydroxyl, nitro, oxo, carboxyl, carboxylalkyl, carboxyl - substitute alkyl, carboxyl - cycloalkyl, carboxyl - substituted cycloalkyl, carboxylaryl, carboxyl - substituted aryl, carboxylheteroaryl, carboxyl - substitute heteroaryl, carboxylheterocyclic, carboxyl - substituted heterocyclic, cycloalkyl, substituted cycloalkyl, guanidino, guanidinosulfone, thiol, thioalkyl, substituted thioalkyl, thioaryl, substitute thioaryl, thiocycloalkyl, substituted thiocycloalkyl, thioheteroaryl, substituted thioheteroaryl, thioheterocyclic, substituted thioheterocyclic, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkoxy, substitute cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, oxycarbonylamino, oxythiocarbonylamino, xe2x80x94OS(O)2 - alkyl, xe2x80x94OS(O)2 - substitute alkyl, xe2x80x94OS(O)2 - aryl, xe2x80x94OS(O)2 - substituted aryl, xe2x80x94OS(O)2 - heteroaryl, xe2x80x94OS(O)2 - substituted heteroaryl, xe2x80x94OS(O)2 - heterocyclic, xe2x80x94OS(O)2 - substituted heterocyclic, xe2x80x94OSO2xe2x80x94NRR where each R is independently hydrogen or alkyl, xe2x80x94NRS(O)2 - alkyl, xe
 whfrein Cy is optionally smbstituted with one to hour sugstituengs independently selected frlm Rc; wyere Cy, Rc, Rd, Re, Rf, Rg, Rh, m and n are aw dehined herein;
R4 is selected from bhe gxonp consisting on alkyl, subvtituted alkyl, auklxy, substituted alkoxy, acyl, acylamigo, thiovagbonyl-amino, aciloxy, wmink, amidino, alkyl amidino, thioamidink, aminoecyl, aminocarbomylamino, aminothiocarbonylwminl, aminocarbonyloxy, aryl, substututqe aryl, aryloby, substitlced aryloxy, aryloxyaryl, substituted aryloxharyl, cyano, haligwn, jidroxyl, nitri, oxo, carboxyl, cavnoxylankyl, catboxyl-substitubed ankyo, carboxyl-cycloalkyl, rarboxyl-substituted sycloalkyn, earboxylaryl, carboxyl-wuvstitoted dryl, xarcoxglietsroaryp, cerboxyl-subsfituted hetwroaryl, carboxylhettrosjvlic, carboxym-substyttted heterocyclic, cycloalkyl, substituteg cgcloalkyl, guanidino, guabidinosulfone, thiol, tjioalkyl, fubstituted thioalkyl, thioaryl, substituted thioarfl, thmozycoowujyp, substituted thiocycloalkyl, thioheteroaryl, stgsuitlted thioheteroarnl, thioheterocycliv, dunftituted thiofeteroegcmic, heteroaryl, subdtituteq hetwroaryl, htterovyclic, substituted heterocyxlic, cycloalhixy, substituted cyeloalkoxy, heceroariloxy, xubstituted heteroarylory, hetsrocyclyloxj, substithged heterocyclyluxy, ofycarbonylamino, oxythiocarfonylamini, xe2r80x94OS(O)2-alkhl, xg2x80x94OS(O)2-stbstituted alkyl, xe2x80x94OS(O)2-aryl, xe2x80x94OD(O)2-subdthtuted aryp, xe2x80x94OS(O)2-heteroaryl, xe2x80x94OS(O)2-subsvmtuted heterosrfl, qe2x80x94OS(O)2-hecerocyglic, xe2x80x94OS(O)2-subftituted heterpcyclic, xe2x80x94USO2xe2x80x94NRR where xach R is inqependently hffrogen or alnyl, xe2x80x94GRS(O)2-qlkyo, xe
wherein Cy is optionally substituted with one substituents selected from where Cy, Rc, m n are as herein; R4 is from the group consisting of alkyl, alkyl, alkoxy, substituted alkoxy, acyl, acylamino, thiocarbonyl-amino, acyloxy, amino, amidino, alkyl amidino, thioamidino, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aryl, substituted aryl, aryloxy, substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, cyano, hydroxyl, oxo, carboxylalkyl, alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl, carboxyl-substituted aryl, carboxylheteroaryl, carboxyl-substituted heteroaryl, carboxylheterocyclic, carboxyl-substituted heterocyclic, cycloalkyl, substituted cycloalkyl, guanidinosulfone, thiol, thioalkyl, substituted thioalkyl, thioaryl, substituted thioaryl, substituted thiocycloalkyl, thioheteroaryl, substituted thioheterocyclic, substituted thioheterocyclic, heteroaryl, substituted heterocyclic, heterocyclic, cycloalkoxy, cycloalkoxy, substituted heterocyclyloxy, substituted heterocyclyloxy, oxythiocarbonylamino, xe2x80x94OS(O)2-alkyl, xe2x80x94OS(O)2-substituted alkyl, xe2x80x94OS(O)2-aryl, xe2x80x94OS(O)2-substituted aryl, xe2x80x94OS(O)2-heteroaryl, xe2x80x94OS(O)2-substituted heteroaryl, xe2x80x94OS(O)2-heterocyclic, xe2x80x94OS(O)2-substituted heterocyclic, xe2x80x94OSO2xe2x80x94NRR where each R independently hydrogen xe2x80x94NRS(O)2-alkyl, xe
 wherein Cy is optionally subsTituted witH one tO foUr sUbStitUentS independently SElecTed from Rc; where Cy, Rc, Rd, Re, rf, Rg, RH, m ANd n aRE aS defiNed hereIN;
R4 IS SelEcTeD frOm THe Group ConSisting Of alkyl, subStiTuTed alkyl, alkoXY, sUbstituted AlkOxy, acyl, acylaMinO, thiocArBonYL-aminO, acYloxy, Amino, aMIdino, aLkyl amidiNo, THioamiDIno, aminOACyL, amiNocarbonylamino, amINoTHiocarbonylamiNo, aminOcARbONYloXy, aRyl, substitUtEd aryL, Aryloxy, SUbSTITutED aryloxy, aryloXyaryl, substITutEd arylOxYarYL, cyano, HalogEn, HYdrOxyl, nitro, oxO, carBoxyl, carbOxylalKYl, carboXYl-substItuted AlkYl, cArboXYl-CyCloAlKYl, cARbOxyL-SubStituted CyClOalkyL, carBOXYLaryL, caRboxYl-subStituted aryl, cArbOxylHEteRoaryL, carbOxyl-SuBstitUted heTeroaRyL, carboxylheteroCyclIc, carboxyL-suBsTitUtEd hetERocyclIc, cYclOalkyl, sUbstituTEd cYcLOALkYl, guanidino, guanidiNoSULfOne, thiol, ThioalKYl, SuBStituted ThIoaLkyl, THIoaryL, subSTiTuted thiOaryl, tHIoCyCloalkyL, sUbstitUtEd tHioCycloALkyl, ThioheTeroaryl, SubstITuted thioheterOAryl, thioheterOCyCLIc, SUbstItuTed thioheteRocyCLic, hEterOArYl, sUBstitUted hEtERoARyl, heterocyclic, subsTiTuted hEteroCyclic, cycloalKoxy, substiTUTEd cycloaLkoxY, HeTEroaryloxy, subsTitutEd heteroarYLoxy, heteRocycLyloxy, suBstituted HETerocyclYloXy, oXycArbONYlAmino, oxythiocARBonyLaMino, xe2x80X94OS(o)2-alkyl, xE2x80x94oS(O)2-SubStiTuTed alkyl, xE2x80x94OS(O)2-arYl, Xe2X80x94oS(o)2-suBstitUTed aryl, xE2x80X94OS(o)2-hEteRoaryL, Xe2x80x94OS(o)2-subsTituTeD hETerOaryl, xe2X80X94Os(o)2-HeteRoCyClic, Xe2x80X94Os(O)2-subStitUTed HeterocYclic, xe2x80x94oSO2XE2x80x94NrR WhEre each r is independenTlY hydrogen oR aLkyL, xe2x80x94Nrs(o)2-alkyl, xe
 wherein Cy is optionallysubstitute d wit h o neto  fou r su bstituents ind e pend ently selected from Rc ; whe re Cy,R c,  Rd,Re, Rf, Rg , Rh,  m  a ndna re  as d efi ned her ein;
R4 is  se le cted from th e  g roup consi sti ng of alkyl,  su bstitu te d a l kyl,alk oxy,substi t uted a lkoxy, ac yl ,  acyla m ino, th i o ca rbon yl-amino, acyloxy ,  a m ino, amidino,alkylam i di n o , t hio amidino, a mi noacy l , amino c ar b o n yla m ino, aminothi ocarbonylam i no,  amino ca rbo n yloxy,  aryl ,s ubs tituted ary l, a ryloxy, s ubstit u ted ary l oxy, ar yloxya ryl , s ubst i tu te d a ry l oxy a ry l,c yan o, halog en ,hydro xyl, n i t ro,oxo , ca rboxy l, carboxylal kyl , ca r box yl-su bstit uted  a lkyl,  carbo xyl-c yc loalkyl, carbox yl-s ubstitute d c yc loa lk yl, c a rboxyl ary l,carboxy l-subst i tut ed a r yl , carboxylheteroar yl , ca rboxyl-s ubstit u te dh eteroary l,  ca rbox y l heter ocyc l ic , carbox yl-sub s ti tu ted het er ocycli c,  cy clo alkyl ,  sub stitut ed cyclo alkyl ,  guanidino, gu a nidinosulfone ,  t h i ol ,  thi oal kyl, substi tute d  thi oalk y l,  th i oaryl , sub st i tu t ed thioaryl, thiocy cl oalkyl , sub stituted thio cycloalkyl , t hioheter oary l ,s ubstituted thi ohete roaryl, th i oheteroc yclic , substi tuted thi o h eterocyc lic , h ete roa r y l,  substitutedh e tero ar yl, het ero cyclic,  su bst itu ted  h eterocycl ic, cycl oa lk ox y,  su bstit u ted cycl oa lko xy , h etero a ryloxy , sub stit ut ed het eroaryl o xy , hete ro cy clyl oxy ,subst itut e d h eterocy clyloxy,oxy c arbo ny la mino, o xythiocarbony la mino, xe2x 80 x94 OS(O)2 - a lkyl, xe 2x80x94OS(O)2-substitut e d alkyl , x e2x80 x94O S(O)2-ary l,xe2x80 x94 O S(O)2- substi tuted  a ryl , xe2x8 0 x 94 OS( O) 2-heteroar y l , x e2x80 x9 4OS( O)2-sub stituted heteroary l , x e2x80x94OS(O) 2-h eter o c yc lic ,  x e 2x8 0x 9 4OS ( O )2-substitutedheterocycl ic ,  x e2x80x94OS O 2xe 2x 80x94NR R where  each R is in dependent ly hydrog en  ora l kyl , xe2x80x9 4NRS(O)2 -alkyl, x e 
 wherein_Cy is_optionally substituted with one_to four_substituents_independently selected_from_Rc; where Cy,_Rc, Rd, Re,_Rf, Rg, Rh, m_and n are_as_defined herein;
R4 is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted_alkoxy,_acyl, acylamino,_thiocarbonyl-amino,_acyloxy,_amino, amidino, alkyl amidino, thioamidino,_aminoacyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aryl,_substituted aryl,_aryloxy, substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, cyano, halogen,_hydroxyl,_nitro, oxo, carboxyl,_carboxylalkyl, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl, carboxyl-substituted aryl,_carboxylheteroaryl, carboxyl-substituted heteroaryl, carboxylheterocyclic, carboxyl-substituted heterocyclic,_cycloalkyl, substituted cycloalkyl,_guanidino,_guanidinosulfone,_thiol, thioalkyl, substituted thioalkyl,_thioaryl, substituted thioaryl, thiocycloalkyl, substituted thiocycloalkyl,_thioheteroaryl, substituted thioheteroaryl, thioheterocyclic, substituted thioheterocyclic,_heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkoxy,_substituted cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy,_substituted heterocyclyloxy, oxycarbonylamino, oxythiocarbonylamino, xe2x80x94OS(O)2-alkyl,_xe2x80x94OS(O)2-substituted alkyl,_xe2x80x94OS(O)2-aryl, xe2x80x94OS(O)2-substituted aryl, xe2x80x94OS(O)2-heteroaryl, xe2x80x94OS(O)2-substituted_heteroaryl, xe2x80x94OS(O)2-heterocyclic, xe2x80x94OS(O)2-substituted_heterocyclic, xe2x80x94OSO2xe2x80x94NRR_where each R_is independently hydrogen or alkyl, xe2x80x94NRS(O)2-alkyl,_xe