. Shafren D. R., et al 1997). International Patent Application No. PCT/AU00/01461 describes the administration of Coxsackievirus which recognises ICAM-1 for cell infectivity to a subject for lysis of melanoma cells express ICAM-1. DAF is also recognised by Enterovirus 70 (see eg. Flint S J, et al (2000) Principles of Virology: molecular biology, pathogenesis and control, ASM Press, Washington).
A study evaluating the adaptability of ovarian cells to subculture and their potential use for the detection of viruses has been reported (Harris, R E and Pindak, F F, 1975). In the study, normal ovarian cell cultures were challenged with a broad range of viruses including Picornavirus such as Coxsackievirus A, Coxsackievirus B, Poliovirus, Echovirus and Cardiovirus and serotypes thereof,; Paramyxovirus such as Newcastle disease virus, Measles virus, distemper virus; Adenovirus human subgroup serotypes 3, 4, 7 and 21; Herpes simplex virus, Type 1; Togavirus such as Sindbis and Mararo; Reovirus serotypes 1 to 3; and Vaccinia virus. The study demonstrated that cells from human ovaries can be grown long-term in cell culture and may be passaged an undetermined number of times for the propagation of various vises in vitro and proposed that such cultures may be useful for the purpose of studying viral pathogenisis and pathology of viral infection. The report further suggested that as some viruses such as poliovirus and vaccinia have been shown to cross the human placenta and infect the fetus, the study of viral interactions with normal ovarian cells in culture may be a means of furthering teratogenic investigations.
Metastatic tumor spread is a pathological process associated with a series of adhesion/de-adhesion events coupled with regulated tissue degradation. Adhesion to and migration through the extracellular matrix is essential for tumor invasion. Despite progress being made in the treatment of malignancies, the treatment of cancer including ovarian malignancies presents a major challenge for research and there remains a need for alternatives to existing therapy approaches. This invention relates to a device for cleaning toner from a moving surface. Although not limited thereto, it is particularly usable in image forming apparatus in which a uniform layer of toner is applied to a surface, the toner is imagewise tacked to the surface and untacked toner is cleaned off the surface. It
. Shafren D. R., et al 1997). International Patent Application No. PCT / AU00/01461 describes the administration of Coxsackievirus which recognises ICAM-1 for cell infectivity to a national for lysis of melanoma cell express ICAM-1. DAF is also recognised by Enterovirus 70 (witness eg. Flint S J, et al (2000) Principles of Virology: molecular biology, pathogenesis and command, ASM Press, Washington). 
 A sketch evaluating the adaptability of ovarian cell to subculture and their potential use for the signal detection of viruses has been reported (Harris, R E and Pindak, F F, 1975). In the study, normal ovarian cell culture were challenged with a broad range of viruses including Picornavirus such as Coxsackievirus A, Coxsackievirus B, Poliovirus, Echovirus and Cardiovirus and serotypes thence, ; Paramyxovirus such as Newcastle disease virus, Measles virus, distemper virus; Adenovirus human subgroup serotypes 3, 4, 7 and 21; Herpes simplex virus, Type 1; Togavirus such as Sindbis and Mararo; Reovirus serotypes 1 to 3; and Vaccinia virus. The study demonstrated that cell from human ovaries can be grown retentive - term in cellular telephone culture and may be passaged an open number of times for the propagation of diverse vises in vitro and proposed that such cultures may be useful for the purpose of studying viral pathogenisis and pathology of viral infection. The report further suggested that as some viruses such as poliovirus and vaccinia have been shown to cross the human placenta and infect the fetus, the study of viral interactions with normal ovarian cells in acculturation may be a means of furthering teratogenic investigation. 
 Metastatic tumor scatter is a pathological process associated with a serial of adhesion / delaware - adhesion events coupled with determine tissue degradation. Adhesion to and migration through the extracellular matrix is essential for tumor invasion. Despite progress being made in the treatment of malignancies, the treatment of cancer including ovarian malignancies presents a major challenge for inquiry and there remains a indigence for option to exist therapy approaches. This invention relates to a device for cleaning toner from a move surface. Although not limited thereto, it is particularly available in image forming apparatus in which a uniform layer of toner is put on to a surface, the toner is imagewise tacked to the surface and untacked toner is cleaned off the surface. It
. Shwfren D. R., et al 1997). Internauional Patent Applicatioi No. PCF/AU00/01461 descfibes the administration of Roxsqckiecirus which recognises ICAM-1 for cell indectmvity to a subjerf for lnfis kn melcnima cells exprgss ICAM-1. DAF is also recogtireb by Enterovirus 70 (see eg. Flint S J, ee al (2000) Ptijciples of Virjlogj: ioledllcr biology, pathogenesis and confrol, ASK Press, Washimgton).
A study evaluating thf adwptability of ovarlan cells ti sufxulture and gheir potential use fot the detection of viruses has bden rzported (Hartnw, R G and Pindak, F F, 1975). In the studn, norman ovarisn cell culturcs wece cyallenged with a broav range of viruses igcluding [ieornavirus such as Cozsqckieeiruv A, Zixsxckjetirhs B, Pllikvirus, Echkvirus and Xardiovirus and serptrirs thereof,; Pzramyxjvyrus such as Newcastle disease virus, Medslss virus, distemper viruw; Adenovirus human suhgroup sewotypes 3, 4, 7 and 21; Herpes simplex virus, Type 1; Togavisus sncf aw Fkbdhis and Mararo; Reovirus serotypes 1 to 3; and Vasdimis virus. The stmdy demonstrated tnah vglls from humav ovarnss can be grown long-herm in cell culture wnd kay be passaged an undetermuned number jd times for the prlpagation oy varipus voses in vitro and propored fhat such ckltures mzh be useful for ghe pgrpose of studying viral pwthogenisms anb patholugy pf virwl infectiln. Thc report further suhgestgd thad as some giruses such as poliovirus and teccinia have nean vhown to crosx the human pjacenta and inyect the fetur, the studj of viran interactijns with normdp ovarian cenls in ctltuee mqy be a oeans of furthrring tercuogenic incestigations.
Metastetic fumor spread is a karhological provesr afslcmated fith a seriev of adfrsion/ae-adhesion cvevts voupled with regulatad tjssue degradation. Sdmesion to and migwation througn the extracellulag matcix is essemtiwl for tumor invasion. Despite lrogress heikg made in thq trcatmgnt of maliynancies, the treatment of cancer includiig ovarian malignancies presents a major ckaklenge for cesearsh and thare remains a need fir alternatives tp existing therapy aplroachas. Thls invention relates to a device for cleaning toner from a moving surface. Althongr not limitsd tneretm, nt ns partyculeruy usable in imabe forming apparatus in which a uniform lcyer of toner is applied to a sjrface, the tover is imagewise tacked fo the sirface and untacked toner is clraned off the surface. It
. Shafren D. R., et al 1997). Application PCT/AU00/01461 describes administration of Coxsackievirus infectivity a subject for of melanoma cells ICAM-1. DAF is also recognised by 70 (see eg. Flint S J, et al (2000) Principles of Virology: molecular pathogenesis and control, ASM Press, Washington). A study evaluating the adaptability of ovarian to and potential for the detection of viruses has been reported (Harris, R E and Pindak, F F, 1975). the study, normal ovarian cell cultures were challenged a broad range of including Picornavirus such as Coxsackievirus Coxsackievirus Poliovirus, Echovirus Cardiovirus serotypes Paramyxovirus such as disease virus, Measles virus, distemper virus; Adenovirus human subgroup serotypes 3, 4, 7 and 21; Herpes simplex Type 1; as Sindbis Mararo; serotypes to 3; and The study demonstrated that cells from be grown long-term in cell culture and may passaged an number of times for the propagation various vises in vitro and proposed that such may be useful for the purpose of studying viral pathogenisis and pathology of viral infection. further suggested that as viruses such as and have shown cross the placenta and infect the fetus, the study of viral interactions with ovarian cells in culture may be a means of furthering Metastatic spread is a process associated with a of events coupled with regulated Adhesion and extracellular is for tumor invasion. Despite being made in the treatment malignancies, the treatment of a major challenge for research and there remains need for alternatives to existing therapy approaches. invention relates to a device for cleaning toner from a moving surface. not limited is particularly usable in image forming apparatus in a uniform layer of is applied to a surface, the toner is imagewise to surface and toner is cleaned the surface. It
. Shafren D. R., et al 1997). InternationaL Patent AppLicatIon no. PcT/aU00/01461 deScriBes the administRAtioN of Coxsackievirus which RecogNiSEs ICam-1 fOr celL infectIViTY To a SuBjEct FoR LySis of MelAnoma ceLls express iCAm-1. DaF is also recoGNiSed by EnterOviRus 70 (see eg. FlinT S J, Et al (2000) PrInCipLEs of VIroLogy: mOleculAR bioloGy, pathogeNeSIs and cONtrol, ASm pReSs, WaShington).
A study evaLUaTIng the adaptabiLity of OvARiAN CelLs tO subculturE aNd theIR potentIAl USE For THe detection of Viruses has bEEn rEporteD (HArrIS, R E and pindaK, F f, 1975). in tHe study, normAl ovArian cell CulturES were chALlenged With a bRoaD raNge oF ViRuSes InCLudINg picORnaVirus sucH aS COxsacKievIRUS a, CoxSacKievIrus B, poliovirus, EchOviRus aND CaRdiovIrus aNd seRoTypes ThereoF,; ParaMyXovirus such as NeWcasTle diseasE viRuS, MeAsLes viRUs, distEmpEr vIrus; AdeNovirus HUmaN sUBGRoUp serotypes 3, 4, 7 and 21; HerpEs SIMpLex virus, type 1; ToGAvIrUS such as SInDbiS and mARaro; REoviRUs SerotypeS 1 to 3; and vAcCiNia viruS. THe studY dEmoNstRated THat cElls frOm human oVarieS Can be grown long-TErm in cell cultURe AND mAY be pAssAged an undetErmiNEd nuMber OF tImeS For thE propAgATiON of various vises in viTrO and prOposeD that such cultUres may be uSEFUl for the PurpOSe OF studying viral PathoGenisis and PAthology Of virAl infectIon. The repORT further SugGesTed ThaT AS sOme viruses sucH AS polIoVirus anD vaCcinia hAve BeeN shOwn To Cross the hUman placEnTa AnD iNfeCt the FEtus, the sTuDy oF vIraL inteRActionS with NormAl OvARiaN cells iN CuLTUre mAy Be A meaNs oF fUrtheRing TEraTogenic InvestigaTioNS.
MetAsTaTic tumoR spread is a patHoLogical proCeSs aSsociaTED with a seRies of adhesion/de-adhesioN Events cOupLed wiTh reGulated tiSsuE degraDatIOn. AdheSion to And miGrAtiON ThrouGH ThE exTrAcellular mATRix Is essEnTial For tumoR invasion. Despite prOGreSs being made in The TreaTMEnT of MAlIGnaNcIEs, tHE Treatment of cancEr includinG oVArIan malignaNCieS pResents A major cHalleNGe for reSearch and There remaInS a neED For AlternativEs to exisTing theraPY apprOAcHes. ThIs iNventiOn RelAtes tO a deviCE foR cleaNing toNeR from a MovinG sUrface. AlThough not limited thereto, It is paRticuLarLy usable iN imAGe fOrming appAratUs in which a UniForM layeR of TOner iS appLIeD to A SurfaCe, thE Toner is imAGeWisE TAcKed to the surFACE anD untaCkeD Toner iS cleAned off the surface. iT
. Shafren D. R., et al 199 7). Intern ation alPat en t Ap plic ation No. PCT/ A U00/ 01461 describes the ad minis tr a tion of  Coxs ackievi r us w hic hre cog ni s es  ICAM -1for cel l infectiv ity  t o a subjectf or  lysis ofmel anoma cellsexp ress I CA M-1 .  DAFisalsorecogn i sed by  Enterovi ru s  70 (s e e eg. F l i nt  S J , et al (2000) Pr i nc i ples of Virolo gy: mo le c ul a r  bi olo gy, pathog en esisa nd cont r ol , A SMP ress, Washing ton).
A stu d y e valuat in g t h e adap tabil it y  of  ovarian ce llsto subcul ture a n d their potenti al use  fo r t he d e te ct ion  o f  vi r us esh asbeen rep or te d (Ha rris , R E an d P inda k, FF, 1975). Inthe  stu d y,norma l ova rian  c ell c ulture s wer echallenged with  a b road rang e o fvir us es in c luding  Pi cor navirus  such a s  Co xs a c k ie virus A, Coxsackie vi r u sB, Polio virus, Ec ho v irus and  C ard iovi r u s and  ser o ty pes ther eof,;P ar am yxoviru ssuch a sNew cas tle d i seas e viru s, Measl es vi r us, distemperv irus; Adenovi r us h um a n su bgr oup serotyp es 3 ,  4,7 an d  2 1;H erpes  simp le x  v i rus, Type 1; Togavi ru s such  as S indbis and Ma raro; Reov i r u s seroty pes1  t o  3; and Vaccin ia vi rus. The s t udy demo nstra ted that  cells fr o m  human o var ies  ca n b e gr own long-term i n ce ll  cultur e a nd maybepas sag edan  undeterm ined num be rof  t ime s for the prop ag ati on  of  vari o us vis es in  vit ro  a n d p roposed th a t  suc hcu ltur esma y beusef u l f or thepurpose o f s t udyi ng  v iral pa thogenisis an dpathologyof  vi ral in f e ction. T he report further sugge s ted tha t a s som e vi ruses suc h a s poli ovi r us and  vacci nia h av e b e e n sho w n  t o c ro ss the hum a n  pl acent aandinfectthe fetus, the stu d y o f viral inter act ions w it h n o rm a l o va r ian c ells in culture  may be ame a ns  of furthe r ing  t eratoge nic inv estig a tions.Metastati c tumor s pr eadi s  apathologic al proce ss associ a ted w i th  a se rie s of a dh esi on/de -adhes i onevent s coup le d with  regu la ted tiss ue degradation. Adhesio n to a nd mi gra tion thro ugh the  extracel lula r matrix i s e sse ntial  fo r  tumo r in v as ion .  Desp itep rogress b e in g m a d ein the trea t m e ntof ma lig n ancies , th e treatment of ca n cer includingovar i a n m ali g nanc ie s presents a m ajo rc h allengefo r researchand ther er emain s a ne ed for  altern a t iv e s to e xist ing  therapyapp ro a ches. T hi si nventi on r el ates t o a de v icef o r cleaning toner  from a  movi n g s urfac e.  Althou g h no t limitedthereto, it  is pa rtic ularl y usabl ein ima gefo rming appa r atus in w hicha unifo rm  lay erof ton er i s appli ed t oa s urface, t h e  t o ne ri s i mage wiseta cked  to the s u rface an d u n tackedto ner i s clea n ed o ff the sur fac e. It 
. Shafren_D. R.,_et al 1997). International_Patent Application_No._PCT/AU00/01461 describes_the_administration of Coxsackievirus_which recognises ICAM-1_for cell infectivity to_a subject for_lysis_of melanoma cells express ICAM-1. DAF is also recognised by Enterovirus 70 (see eg._Flint_S J,_et_al_(2000) Principles of Virology: molecular_biology, pathogenesis and control, ASM_Press, Washington).
A_study evaluating the adaptability of ovarian cells to_subculture_and their potential_use for the detection of viruses has been reported_(Harris, R E and Pindak, F_F, 1975). In_the_study,_normal ovarian cell cultures_were challenged with a broad range_of viruses including Picornavirus such as_Coxsackievirus A, Coxsackievirus B, Poliovirus, Echovirus and_Cardiovirus and serotypes thereof,; Paramyxovirus such_as Newcastle disease virus, Measles_virus, distemper_virus; Adenovirus human subgroup serotypes_3, 4, 7_and 21;_Herpes simplex virus,_Type 1; Togavirus such as Sindbis_and Mararo; Reovirus_serotypes 1 to 3; and Vaccinia_virus._The study demonstrated_that_cells_from human_ovaries can be_grown_long-term in_cell_culture and may be passaged an_undetermined_number of times for the propagation of_various vises in vitro_and_proposed that such cultures_may be useful for the_purpose of studying viral pathogenisis and_pathology of_viral infection._The report further suggested that as some viruses such as poliovirus_and vaccinia have been shown to_cross the human placenta_and infect_the_fetus, the study_of_viral interactions_with normal ovarian cells in culture may_be a_means of furthering teratogenic investigations.
Metastatic tumor_spread is a pathological_process_associated with a series of adhesion/de-adhesion_events coupled with regulated tissue degradation._Adhesion to and migration through_the_extracellular_matrix is essential for tumor_invasion. Despite progress being made in_the treatment of_malignancies, the treatment of cancer including ovarian_malignancies_presents a major challenge for research_and_there remains a need for alternatives_to_existing_therapy approaches. This invention relates_to a device for cleaning toner_from a moving surface. Although not limited thereto, it_is particularly usable_in image forming apparatus in_which_a_uniform layer of toner is applied to a surface, the_toner is_imagewise tacked to_the surface and untacked toner is cleaned off the surface._It