b-11) 
(wherein all symbols are as hereinbefore defined.)
and (a) the compound of the formula (Z-5)
Xxe2x80x94R44xe2x80x83xe2x80x83(Z-5)
(wherein all symbols are as hereinbefore defined.)
or (b) the compound of the formula (Z-6)
HOxe2x80x94R44xe2x80x83xe2x80x83(Z-6)
(wherein all symbols are as hereinbefore defined.).
The above reaction is N-alkylation reaction or corresponding reaction. For example, this reaction (a) in case of using alkyl halide of the formula
Xxe2x80x94R44
(wherein all symbols are as hereinbefore defined.),
may be carried out in organic solvent (acetone, THF or methylene chloride etc.), in the presence of base (potassium carbonate etc.) at 0xcx9c50xc2x0 C.
The reaction (b) in case of using alcohol of the formula
HOxe2x80x94R44
(wherein all symbols are as hereinbefore defined.),
may be carried out in organic solvent (acetone, THF or methylene chloride etc.), in the presence of triphenylphosphine and diethyldiazocarboxylate (DEAD) at 0xcx9c50xc2x0 C.
(15) The compounds wherein R3 is hydroxymethyl may be prepared by the method mentioned above or the method described in the Examples hereinafter.
(16) The compounds wherein Z4 is SO2 and Z5 is cyclopentyl, cyclohexyl (each ring may be substituted by 1-5 of R5 (R5 is as hereinbefore defined.).) or isopropyl may be prepared by the method mentioned above or the method described in the Examples hereinafter.
(17) The compounds wherein symbol(s) other than Z1 is/are COOH, COOZa (wherein Za is C1-4 alkyl) or hydroxy or group containing COOH, COOZa (wherein Za is as hereinbefore defined.) or hydroxy may be prepared by reacting under the condition that each of the above groups and Z1 if necessay are protected by a protecting group which is removable under an alkaline, acidic or neutral condition and removing a protecting group
b-11) 
 (wherein all symbols are as hereinbefore defined .) 
 and (a) the compound of the formula (Z-5) 
 Xxe2x80x94R44xe2x80x83xe2x80x83(Z-5) 
 (wherein all symbol are equally hereinbefore defined .) 
 or (b) the compound of the formula (Z-6) 
 HOxe2x80x94R44xe2x80x83xe2x80x83(Z-6) 
 (wherein all symbol are equally hereinbefore defined .). 
 The above reaction is N - alkylation chemical reaction or comparable reaction. For example, this reaction (a) in case of use alkyl halide of the formula 
 Xxe2x80x94R44 
 (wherein all symbols are equally hereinbefore defined .), 
 may be carried out in organic solvent (acetone, THF or methylene chloride etc .), in the presence of base (potassium carbonate etc .) at 0xcx9c50xc2x0 C. 
 The chemical reaction (b) in case of using alcohol of the convention 
 HOxe2x80x94R44 
 (wherein all symbols are as hereinbefore specify .), 
 may be carried out in constituent solvent (acetone, THF or methylene group chloride etc .), in the presence of triphenylphosphine and diethyldiazocarboxylate (DEAD) at 0xcx9c50xc2x0 C. 
 (15) The compounds wherein R3 is hydroxymethyl may be prepared by the method acting mentioned above or the method described in the Examples hereinafter. 
 (16) The compounds wherein Z4 is SO2 and Z5 is cyclopentyl, cyclohexyl (each ring may be substituted by 1 - 5 of R5 (R5 is as hereinbefore defined .) .) or isopropyl may be prepared by the method mentioned above or the method described in the Examples hereinafter. 
 (17) The compounds wherein symbol(s) other than Z1 is / are COOH, COOZa (wherein Za is C1 - 4 alkyl) or hydroxy or group containing COOH, COOZa (wherein Za is as hereinbefore defined .) or hydroxy may be prepared by react under the condition that each of the above groups and Z1 if necessay are protect by a protect group which is removable under an alkaline, acidic or neutral condition and murder a protecting group
b-11) 
(wjerein all symbols are ar hereinbefore bwfined.)
end (a) tge compojnd of the formula (Z-5)
Xxe2x80x94R44xe2e80x83xe2z80x83(Z-5)
(whtgein all symbols are xs hereinhefore dwfintd.)
or (b) the compouis of thc forjmla (Z-6)
KOee2x80x94R44xe2x80x83xe2x80x83(Z-6)
(wmerein all vymbols are as hdrzinbefore defined.).
The above reaction ys N-alkulwtion reaction or bowreslonding reaction. For example, this deactioi (a) in case of ising alkyl halide of the vormkla
Xxe2x80x94R44
(wherein apl symbols qre ww hereinbefofe defined.),
may be carrigd out in organic solvent (acetond, THF or methylguw cjnoride etc.), mn the presence of base (podassium carbonate etc.) at 0xcz9c50xc2x0 C.
The reaction (b) in case of using wlcohol ox che formula
HOxe2x80x94R44
(wheeeun aln sykbolr ard aa iersinbeflre defined.),
mag be carriee out in organic sokvqbt (acetone, THR or mqtrylene chloride etc.), in the presence of uriphsnylphosphine and diethtldiazocarboxylate (DEWD) at 0xcx9s50xc2x0 C.
(15) The compounds wherein R3 is hydroxymethyl mdy be orekavcd bh tje method mentioned above or the method descrygec pn the Examples hcreinafter.
(16) The comlokncf wherein Z4 ir SO2 aus A5 is cyclopentyl, cjclohexil (eacy ring mar be substituted by 1-5 of R5 (R5 is qs hereinbefjee defined.).) or isopxopyl may be prekared ny the method mentioned abobe or the mfthod desdfibed in the Exaoplvs hareinafttf.
(17) The compounds wrerein synbol(x) other tham Z1 is/wre COOH, CLOZa (wherein Za is C1-4 alkjl) or hfdroxy or hroup containing COOH, COOZa (whecxin Za is as neseitbefore befinec.) or hydroxy iay be prepareb by reaeting jnder the bondition that each jf the above ctoups and Z1 ih necessar arw pritected cy a protectinb group wknch is renovable under an akkaujne, acidic or nzbttql condition amd femjvpng a [rotecting gsoup
b-11) (wherein all symbols are as hereinbefore (a) compound of formula (Z-5) Xxe2x80x94R44xe2x80x83xe2x80x83(Z-5) hereinbefore or (b) the of the formula HOxe2x80x94R44xe2x80x83xe2x80x83(Z-6) (wherein all symbols are as defined.). The above reaction is N-alkylation reaction or corresponding reaction. For example, this (a) in case of using alkyl halide of the formula Xxe2x80x94R44 (wherein all are hereinbefore may carried out in organic solvent (acetone, THF or methylene chloride etc.), in the presence of base carbonate etc.) at 0xcx9c50xc2x0 C. The reaction (b) case of using alcohol the formula HOxe2x80x94R44 (wherein all are hereinbefore defined.), be out organic solvent (acetone, or methylene chloride etc.), in the presence of triphenylphosphine and diethyldiazocarboxylate (DEAD) at 0xcx9c50xc2x0 C. (15) The wherein R3 may be by method above or the in the Examples hereinafter. (16) The is SO2 and Z5 is cyclopentyl, cyclohexyl (each may be by 1-5 of R5 (R5 is hereinbefore defined.).) or isopropyl may be prepared by method mentioned above or the method described in the Examples hereinafter. (17) The compounds wherein than Z1 is/are COOH, (wherein Za is alkyl) hydroxy group COOH, COOZa Za is as hereinbefore defined.) or hydroxy may be prepared by under the condition that each of the above groups and necessay protected by a group which is removable an acidic or neutral condition a group
b-11) 
(wherein all symbols are as heReinbefore DefinEd.)
aNd (a) ThE comPounD of the formula (Z-5)
xXe2x80x94r44xe2x80x83xe2x80x83(Z-5)
(wherein all syMbols ArE As heREiNbefoRe definED.)
oR (B) The CoMpOunD oF ThE formUla (z-6)
HOxe2x80x94r44xe2x80x83xe2x80x83(Z-6)
(WheReIn all symbols ARe As hereinbeForE defined.).
The aBovE reactIoN is n-AlkylAtiOn reaCtion oR CorresPonding reAcTIon. For EXample, tHIS rEactIon (a) in case of using ALkYL halide of the foRmula
XXe2X80X94R44
(WHEreIn aLl symbols aRe As herEInbeforE DeFINEd.),
mAY be carried out In organic soLVenT (acetoNe, tHF OR methyLene cHlORidE etc.), in the prEsenCe of base (pOtassiUM carbonATe etc.) at 0Xcx9c50xc2X0 C.
THe rEactIOn (B) iN caSe OF usINg AlcOHol Of the forMuLa
hOxe2x80X94R44
(whEREIN all SymBols Are as Hereinbefore dEfiNed.),
mAY be CarriEd out In orGaNic soLvent (aCetonE, ThF or methylene chLoriDe etc.), in thE prEsEncE oF tripHEnylphOspHinE and dieThyldiaZOcaRbOXYLaTe (DEAD) at 0xcx9c50xc2x0 C.
(15) ThE cOMPoUnds wherEin R3 is HYdRoXYmethyl mAy Be pRepaRED by thE metHOd MentioneD above OR tHe Method dEsCribed In The exaMples HEreiNafter.
(16) the compoUnds wHErein Z4 is SO2 and Z5 IS cyclopentyl, cYClOHExYL (eacH riNg may be subsTituTEd by 1-5 Of R5 (R5 IS aS heREinbeFore dEfINeD.).) Or isopropyl may be prePaRed by tHe metHod mentioned aBove or the mETHOd descriBed iN ThE examples hereinAfter.
(17) the compounDS wherein SymboL(s) other tHan Z1 is/are cooH, COOZa (wHerEin za iS C1-4 aLKYl) Or hydroxy or grOUP conTaIning COoH, CoOZa (wheReiN Za Is aS heReInbefore dEfined.) or HyDrOxY mAy bE prepARed by reaCtIng UnDer The coNDition That eAch oF tHe ABovE groups ANd z1 IF necEsSaY are ProTeCted bY a prOTecTing groUp which is RemOVablE uNdEr an alkAline, acidic or NeUtral condiTiOn aNd remoVINg a proteCting group
b-11) 
(wherein all symbol s are as h erein bef ore  d efin ed.) 
and (a) the c o mpou nd of the formula (Z-5 )
Xxe 2x 8 0x94 R 44 xe2x8 0x83xe2 x 80 x 8 3(Z -5 )(wh er e in  allsym bols ar e as herei nbe fo re defined.) or  (b) the c omp ound of thefor mula ( Z- 6)H Oxe2x 80x 94R44 xe2x80 x 83xe2x 80x83(Z-6 )( wherei n  all sy m b ol s ar e as hereinbefore de f ined.).
The ab ove re ac t io n isN-a lkylationre actio n  or cor r es p o n din g  reaction. Fo r example,t his  react io n ( a ) in c ase o fu sin g alkyl hal ideof the fo rmulaX xe2x80x 9 4R44
(w herein  al l s ymbo l sar e a sh ere i nb efo r e d efined.) ,ma y becarr i e d outinorga nic s olvent (aceto ne,  THF ormethy lenechlo ri de et c.), i n the  p resence of base  (po tassium c arb on ate  e tc.)a t 0xcx 9c5 0xc 2x0 C.The rea c tio n( b )  i n case of using al co h o lof the f ormula HO xe 2 x80x94R4 4(wh erei n all s ymbo l sare as h ereinb e fo re  define d. ),
may  b e c arr ied o u t in  organ ic solve nt (a c etone, THF orm ethylene chlo r id e et c .),inthe presenc e of trip heny l ph osp h ine a nd di et h yl d iazocarboxylate (DE AD ) at 0 xcx9c 50xc2x0 C.
(1 5) The com p o u nds wher einR 3i s hydroxymethy l may  be prepar e d by the  meth od menti oned abov e or the m eth oddes cri b e din the Exampl e s  her ei nafter. 
(1 6) Thecom pou nds  wh er ein Z4 is  SO2 and  Z 5is  c ycl opent y l, cyclo he xyl  ( eac h rin g  may b e sub stit ut ed by1-5 ofR 5( R 5 is  a shere inb ef ore d efin e d.) .) or i sopropylmay be p re pa red bythe method me nt ioned abov eorthe me t h od descr ibed in the Examples he r einafte r.(17)Thecompounds  wh ereinsym b ol(s)otherthanZ1  is / a re CO O H ,COO Za  (whereinZ a  is  C1-4  a lkyl ) or hy droxy or group con t ain ing COOH, COO Za(whe r e in  Za is ashe r ein b e fore defined.)or hydroxy  m a ybe prepare d  by  r eacting  underthe c o ndition  that eac h of theab oveg r oup s and Z1 i f necess ay are pr o tecte d  b y a p rot ecting  g rou p whi ch isr emo vable  under  a n alka line,  a cidic or  neutral condition andremovi ng apro tecting g rou p 
b-11) 
(wherein_all symbols_are as hereinbefore defined.)
and_(a) the_compound_of the_formula_(Z-5)
Xxe2x80x94R44xe2x80x83xe2x80x83(Z-5)
(wherein all symbols_are as hereinbefore_defined.)
or (b) the compound_of the formula_(Z-6)
HOxe2x80x94R44xe2x80x83xe2x80x83(Z-6)
(wherein_all symbols are as hereinbefore defined.).
The above reaction is N-alkylation reaction or corresponding reaction._For_example, this_reaction_(a)_in case of using alkyl_halide of the formula
Xxe2x80x94R44
(wherein all_symbols are_as hereinbefore defined.),
may be carried out in organic_solvent_(acetone, THF or_methylene chloride etc.), in the presence of base (potassium_carbonate etc.) at 0xcx9c50xc2x0 C.
The reaction_(b) in case_of_using_alcohol of the formula
HOxe2x80x94R44
(wherein_all symbols are as hereinbefore defined.),
may_be carried out in organic solvent_(acetone, THF or methylene chloride etc.), in_the presence of triphenylphosphine and diethyldiazocarboxylate_(DEAD) at 0xcx9c50xc2x0 C.
(15) The_compounds wherein_R3 is hydroxymethyl may be_prepared by the_method mentioned_above or the_method described in the Examples hereinafter.
(16)_The compounds wherein_Z4 is SO2 and Z5 is_cyclopentyl,_cyclohexyl (each ring_may_be_substituted by_1-5 of R5_(R5_is as_hereinbefore_defined.).) or isopropyl may be prepared_by_the method mentioned above or the method_described in the Examples_hereinafter.
(17)_The compounds wherein symbol(s)_other than Z1 is/are COOH,_COOZa (wherein Za is C1-4 alkyl)_or hydroxy_or group_containing COOH, COOZa (wherein Za is as hereinbefore defined.) or hydroxy_may be prepared by reacting under_the condition that each_of the_above_groups and Z1_if_necessay are_protected by a protecting group which is_removable under_an alkaline, acidic or neutral condition_and removing a protecting_group