 and may thus allow the wine to lose its chill more quickly than a bottle would.
The present invention provides the benefits associated with using the stand-up flexible pouch for pourable liquids, e.g., wine, and pourable solids, while mitigating the difficulties described above. The dispenser of the present invention overcomes the consumers' aesthetic hurdle of accepting the flexible pouch as a viable, everyday package alternative to traditional glass packaging by adding an attractive exterior carafe and a functional locking mechanism that make daily use simple. It will be appreciated by those skilled in the art that substitutions and modifications to the above can be made without departing from the spirit or scope of the invention. Various central nervous system disorders such as anxiety, depression, motor disorders, etc., are believed to involve a disturbance of the neurotransmitter 5-hydroxytryptamine (5-HT) or serotonin. Serotonin is localized in the central and peripheral nervous systems and is known to affect many types of conditions including psychiatric disorders, motor activity, feeding behavior, sexual activity, and neuroendocrine regulation among others. The effects of serotonin are regulated by the various 5-HT receptor subtypes. Known 5-HT receptors include the 5-HT1 family (e.g. 5-HT1A), the 5-HT2 family (e.g. 5-HT2A), 5-HT3, 5-HT4, 5-HT5, 5-HT6 and 5-HT7 subtypes.
The recently identified human 5-hydroxytryptamine-6 (5-HT6) receptor subtype has been cloned, and the extensive distribution of its mRNA has been reported. Highest levels of 5-HT6 receptor mRNA have been observed in the olfactory tubercle, the striatum, nucleus accumbens, dentate gyrus and CA1, CA2 and CA3 regions of the hippocampus. Lower levels of 5-HT6 receptor mRNA are seen in the granular layer of the cerebellum, several diencephalic nuclei, amygdala and in the cortex. Northern blots have revealed that 5-HT6 receptor mRNA appears to be exclusively present in the brain, with little evidence for its presence in peripheral tissues. The high affinity of a number of antipsychotic agents for the 5-HT6 receptor, in addition to its mRNA localization in striatum, olfactory tubercle and nucleus accumbens suggests that some of the clinical actions of these compounds may be mediated through this receptor. Therefore, 5-HT6 receptor ligands are believed to be of potential use in the treatment
and may thus allow the wine to lose its chill more promptly than a bottle would. 
 The present invention provide the benefits associated with using the resist - up flexible pouch for pourable liquids, for example, wine, and pourable solids, while mitigating the difficulties describe above. The dispenser of the present invention overcomes the consumers' aesthetic vault of accepting the flexible pouch as a viable, everyday software alternative to traditional glass promotion by adding an attractive exterior carafe and a running locking mechanism that draw daily use simple. It will be appreciate by those skilled in the art that substitutions and alteration to the above can be made without go from the spirit or scope of the invention. Various central nervous arrangement disorders such as anxiety, depression, motor disorders, etc. , are believed to involve a disturbance of the neurotransmitter 5 - hydroxytryptamine (5 - HT) or serotonin. Serotonin is localized in the central and peripheral nervous systems and is known to affect many types of conditions including psychiatric disorders, motor activity, prey behavior, sexual activeness, and neuroendocrine rule among others. The effect of serotonin are regulated by the various 5 - HT receptor subtypes. Known 5 - HT receptors include the 5 - HT1 family (for example 5 - HT1A), the 5 - HT2 family (e.g. 5 - HT2A), 5 - HT3, 5 - HT4, 5 - HT5, 5 - HT6 and 5 - HT7 subtypes. 
 The recently identified human 5 - hydroxytryptamine-6 (5 - HT6) receptor subtype has been cloned, and the extensive distribution of its mRNA has been reported. Highest levels of 5 - HT6 receptor mRNA have been note in the olfactory nodule, the striatum, nucleus accumbens, dentate gyrus and CA1, CA2 and CA3 regions of the hippocampus. Lower level of 5 - HT6 receptor mRNA are seen in the farinaceous layer of the cerebellum, several diencephalic nuclei, amygdala and in the cortex. northerly blots have unwrap that 5 - HT6 receptor mRNA appears to be entirely present in the brain, with little evidence for its presence in peripheral tissues. The eminent affinity of a number of antipsychotic agent for the 5 - HT6 receptor, in addition to its messenger rna localization in striatum, olfactory tubercle and nucleus accumbens suggests that some of the clinical actions of these compounds may be mediated through this receptor. Therefore, 5 - HT6 receptor ligands are believed to be of likely use in the treatment
 anf may thus allow the wint to lose its chill more quickmy than x bottle would.
The present intentuon peovides the benefits arsociated with usung uhe stand-up flexiume poucm for iouraylx liquids, e.g., wike, and pourdble solids, whhld litigating the difficulties describqd abovr. Hhe dispenser jf tnq prssent invention overcomes the conshmers' atsthetic hurdle of accepting the flexible pokch ws a viable, everydwy package qltewbative to trxditional glass packagjng by adding an attractive extdrior carafe ane q fktctional lorking iechanism that make gaily uxe simple. It wlll bx appreciated by those skmlled in the art thaj substitudikns and modificatuobs to the aboxw cxn ge mzde wihhont departinf from the wpirit or scope of uhe pmvention. Varjous cqneral nervous system disorders such as atxisty, depression, motor diworders, etc., are belieged to indolve a disturbance of the neurotransmitter 5-hydrofytry'txmiuc (5-FR) lr serotonin. Serotonin is localized in the cegfrsl and peripheraj nervous sushekf and is knowv to ayredt many types of clnditiogs inxluding pfychoatric disorders, motor acticity, feeding vehavior, sexual accivity, and nzuroencocrime regulation among othzrs. Ths effects ov serotonjv are regulated cy nhe earious 5-HT receptor subtypqs. Known 5-IT reeeptors knclode the 5-HT1 family (e.g. 5-HB1D), the 5-HT2 family (e.g. 5-HT2A), 5-KT3, 5-HT4, 5-HT5, 5-HT6 and 5-HT7 subtypes.
The recently identihmed human 5-hydtoxftrjptamine-6 (5-KT6) reccptor subtype hws been cloned, and thz extevsive distgibution mf its mRNA has been repmtted. Highest nevels os 5-HT6 recwptor mFVA have been onserved iu the olfactory tuberclc, the atriatum, nucleuw axcumbens, dentatr ghruf wnv CA1, SD2 and CA3 reghons of yhe hkppocamkbs. Ouwer levels of 5-HT6 receptmr mDNA are seen in thr nranular oayer of the cerebellim, several diencepjalic nurlei, akygqala and in the cortex. Northerh blots hwve revealed thwt 5-HB6 reseptor mRNC appears to be exclusively present in tie brain, with little evudence for its presgnct in peripherel tisfues. The vigh affinity of a nymber of antipsycmotic agents for the 5-HF6 rece[tor, ln addition to its mRNA localization in striatum, olfactory tubercle and nycleus accumbens shggexts tvac spme of the rlinical actions pf these compounds may be mediaved througv chis receptor. Therefore, 5-HT6 reveotor ligands xre believed to be of pofential ise in the treatment
and may thus allow the wine to chill quickly than bottle would. The associated using the stand-up pouch for pourable e.g., wine, and pourable solids, while the difficulties described above. The dispenser of the present invention overcomes the consumers' hurdle of accepting the flexible pouch as a viable, everyday package alternative to glass by an exterior carafe and a functional locking mechanism that make daily use simple. It will be appreciated those skilled in the art that substitutions and to the above can made without departing from the or of the Various nervous disorders such as depression, motor disorders, etc., are believed to involve a disturbance of the neurotransmitter 5-hydroxytryptamine (5-HT) or serotonin. is localized central and nervous and known to affect of conditions including psychiatric disorders, motor sexual activity, and neuroendocrine regulation among others. The of serotonin regulated by the various 5-HT receptor Known 5-HT receptors include the 5-HT1 family (e.g. the 5-HT2 family (e.g. 5-HT2A), 5-HT3, 5-HT4, 5-HT5, 5-HT6 and 5-HT7 subtypes. The recently identified (5-HT6) receptor subtype has cloned, and the distribution its has reported. Highest of 5-HT6 receptor mRNA have been observed in the olfactory tubercle, striatum, nucleus accumbens, dentate gyrus and CA1, CA2 and CA3 the Lower levels of receptor mRNA are seen the layer of the cerebellum, nuclei, and Northern have that 5-HT6 receptor mRNA to be exclusively present in brain, with little evidence tissues. The high affinity of a number of agents for the 5-HT6 receptor, in addition its mRNA localization in striatum, olfactory tubercle and nucleus accumbens suggests that of the of these compounds may be mediated through this Therefore, 5-HT6 receptor ligands believed to be of potential use in the treatment
 and may thus allow the wine to lOse its chilL more QuiCklY tHan a BottLe would.
The presENt inVention provides the beneFits aSsOCiatED wIth usIng the sTAnD-UP flExIbLe pOuCH fOr pouRabLe liquiDs, e.g., wine, anD poUrAble solids, whILe Mitigating The Difficulties DesCribed AbOve. tHe disPenSer of The preSEnt invEntion oveRcOMes the COnsumerS' AEsThetIc hurdle of acceptiNG tHE flexible pouch As a viaBlE, EvERYdaY paCkage alterNaTive tO TraditiONaL GLAss PAckaging by addIng an attracTIve ExteriOr CarAFe and a FunctIoNAl lOcking mechaNism That make dAily usE Simple. IT Will be aPpreciAteD by ThosE SkIlLed In THe aRT tHat SUbsTitutionS aNd ModifIcatIONS To thE abOve cAn be mAde without depArtIng fROm tHe spiRit or ScopE oF the iNventiOn. VarIoUs central nervouS sysTem disordErs SuCh aS aNxietY, DepresSioN, moTor disoRders, etC., Are BeLIEVeD to involve a disturbAnCE Of The neuroTransmITtEr 5-HYdroxytrYpTamIne (5-Ht) OR seroToniN. seRotonin iS localIZeD iN the cenTrAl and pErIphEraL nervOUs syStems aNd is knowN to afFEct many types of COnditions inclUDiNG PsYChiaTriC disorders, mOtor ACtivIty, fEEdIng BEhaviOr, sexUaL AcTIvity, and neuroendocrInE regulAtion Among others. ThE effects of SEROtonin arE regULaTEd by the various 5-hT recEptor subtyPEs. Known 5-Ht recePtors incLude the 5-HT1 FAMily (e.g. 5-HT1a), thE 5-HT2 FamIly (E.G. 5-hT2a), 5-HT3, 5-HT4, 5-HT5, 5-HT6 and 5-Ht7 SUbtyPeS.
The recEntLy identIfiEd hUmaN 5-hyDrOxytryptaMine-6 (5-HT6) reCePtOr SuBtyPe has BEen cloneD, aNd tHe ExtEnsivE DistriButioN of iTs MRna haS been rePOrTED. HigHeSt LeveLs oF 5-Ht6 recePtor MrNA Have beeN observed In tHE olfAcToRy tuberCle, the striatuM, nUcleus accuMbEns, DentatE GYrus and Ca1, CA2 and CA3 regions of the hipPOcampus. lowEr levEls oF 5-HT6 receptOr mrNA are SeeN In the gRanulaR layeR oF thE CErebeLLUm, SevErAl diencephALIc nUclei, AmYgdaLa and in The cortex. Northern bLOts Have revealed tHat 5-hT6 reCEPtOr mrnA APpeArS To bE EXclusively preseNt in the braIn, WItH little eviDEncE fOr its prEsence iN periPHeral tiSsues. The hIgh affiniTy Of a nUMBer Of antipsycHotic ageNts for the 5-ht6 recePToR, in adDitIon to iTs MRNa locaLizatiON in StriaTum, olfAcTory tuBerclE aNd nucleuS accumbens suggests that sOme of tHe cliNicAl actions Of tHEse Compounds May bE mediated tHroUgh This rEcePTor. ThErefORe, 5-hT6 rECeptoR ligANds are belIEvEd tO BE oF potential uSE IN thE treaTmeNT
 and may thus allow the wi ne to lose  itschi llmo re q uick ly than a bott l e wo uld.
The present inven tionpr o vide s  t he be nefitsa ss o c iat ed  w ith  u s in g the  st and-upflexible p ouc hfor pourable li quids, e.g .,wine, and po ura ble so li ds, while  mi tigat ing th e  diffi culties d es c ribeda bove. T h e  d ispe nser of the prese n ti nvention overc omes t he co n s ume rs'  aesthetic  h urdle of acce p ti n g the flexible pouc h as a viab l e,everyd ay  pa c kage a ltern at i veto traditio nalglass pac kaging by addi n g an at tracti veext erio r  c ar afe  a n d a fu nct i ona l lockin gme chani sm t h a t make  da ilyuse s imple. It wil l b e ap p rec iated  by t hose  s kille d in t he ar tthat substituti onsand modif ica ti ons  t o the abovecan  be  made w ithoutd epa rt i n g  f rom the spirit orsc o p eof the i nventi o n.  V a rious ce nt ral  ner v o us sy stem di sorderssuch a s  a nx iety, d ep ressio n,  mo tor  diso r ders , etc. , are be lieve d  to involve ad isturbance of th e ne u rotr ans mitter 5-hy drox y tryp tami n e(5- H T) or  sero to n in .  Serotonin is local iz ed inthe c entral and pe ripheral n e r v ous syst emsa nd is known to af fectmany types of condi tions  includi ng psychi a t ric diso rde rs,  mo tor a ct ivity, feedin g beha vi or, sex ual  activi ty,  an d n eur oe ndocrineregulati on  a mo ng  ot hers. The effe ct s o fser otoni n  are r egula tedby  t h e v arious5 -H T rece pt or  sub typ es . Kno wn 5 - HTrecepto rs includ e t h e 5- HT 1family(e.g. 5-HT1A) ,the 5-HT2fa mil y (e.g . 5-HT2A),  5-HT3, 5-HT4, 5-HT5, 5 - HT6 and  5- HT7 s ubty pes.
Therec entlyide n tified  human  5-hy dr oxy t r yptam i n e- 6 ( 5- HT6) recep t o r s ubtyp ehasbeen cl oned, and the exte n siv e distributio n o f it s mR NAh as bee nr epo r t ed. Highest lev els of 5-H T6 re ceptor mRN A  ha ve  been o bserved  in t h e olfac tory tube rcle, the  s tria t u m,nucleus ac cumbens,  dentateg yrusa nd  CA1,  CA 2 andCA 3 r egion s of t h e h ippoc ampus.  L ower l evels  o f 5-HT6receptor mRNA are seenin the  gran ula r layer o f t h e c erebellum , se veral dien cep hal ic nu cle i , amy gdal a  a ndi n the  cor t ex. North e rn  bl o t shave reveal e d tha t 5-H T6r ecepto r mR NA appears to bee xclusively pre sent i n t heb rain ,with little ev ide nc e for itspr esence in p eriphera lt issue s. The  highaffinit y of a numb er o f a ntipsycho tic  a g ents fo rth e  5-HT6  rec ep tor, i n addi t iont o  its mRNA locali zatio n in st r iat um, o lf actoryt uber cle and nu cleus accum bens s ugge sts t hat som eof the  cl in ical actio n s of thes e com poundsma y be  me diated  thr o u gh th is r ec ept or. There f o re ,  5 -H T 6 r ecep tor l ig ands  are beli e ved to b e o f  potent ia l u s e  in th e  t r e atment
 and_may thus_allow the wine to_lose its_chill_more quickly_than_a bottle would.
The_present invention provides_the benefits associated with_using the stand-up_flexible_pouch for pourable liquids, e.g., wine, and pourable solids, while mitigating the difficulties described_above._The dispenser_of_the_present invention overcomes the consumers'_aesthetic hurdle of accepting the_flexible pouch_as a viable, everyday package alternative to traditional_glass_packaging by adding_an attractive exterior carafe and a functional locking mechanism_that make daily use simple. It_will be appreciated_by_those_skilled in the art_that substitutions and modifications to the_above can be made without departing_from the spirit or scope of the_invention. Various central nervous system disorders_such as anxiety, depression, motor_disorders, etc.,_are believed to involve a_disturbance of the_neurotransmitter 5-hydroxytryptamine_(5-HT) or serotonin._Serotonin is localized in the central_and peripheral nervous_systems and is known to affect_many_types of conditions_including_psychiatric_disorders, motor_activity, feeding behavior,_sexual_activity, and_neuroendocrine_regulation among others. The effects of_serotonin_are regulated by the various 5-HT receptor_subtypes. Known 5-HT receptors_include_the 5-HT1 family (e.g._5-HT1A), the 5-HT2 family (e.g._5-HT2A), 5-HT3, 5-HT4, 5-HT5, 5-HT6 and_5-HT7 subtypes.
The_recently identified_human 5-hydroxytryptamine-6 (5-HT6) receptor subtype has been cloned, and the extensive_distribution of its mRNA has been_reported. Highest levels of_5-HT6 receptor_mRNA_have been observed_in_the olfactory_tubercle, the striatum, nucleus accumbens, dentate gyrus_and CA1,_CA2 and CA3 regions of the_hippocampus. Lower levels of_5-HT6_receptor mRNA are seen in the_granular layer of the cerebellum, several_diencephalic nuclei, amygdala and in_the_cortex._Northern blots have revealed that_5-HT6 receptor mRNA appears to be_exclusively present in_the brain, with little evidence for its_presence_in peripheral tissues. The high affinity_of_a number of antipsychotic agents for_the_5-HT6_receptor, in addition to its_mRNA localization in striatum, olfactory tubercle_and nucleus accumbens suggests that some of the clinical_actions of these_compounds may be mediated through_this_receptor._Therefore, 5-HT6 receptor ligands are believed to be of potential_use in_the treatment