 [8] or its salt to produce a compound of the general formula [6] or its salt and thereafter subjecting the compound of the general formula [6] or its salt to ring-closing reaction or alternatively by ring-closing the compound [8] or its salt to produce a compound of the general formula [7] or its salt and thereafter subjecting the compound of the general formula [7] or its salt to reduction reaction.
The solvent which is used in this reduction reaction may be any solvent as far as it does not adversely affect the reaction, and includes, for example, alcohols such as methanol, ethanol, isopropanol and the like; ethers such as tetrahydrofuran, dioxane, 1,2-dimethoxyethane, diethylene glycol dimethyl ether and the like; nitrites such as acetonitrile and the like; amides such as N,N-dimethylformamide and the like; sulfoxides such as dimethylsulfoxide and the like; water; etc. These solvents may be used in admixture.
The reducing agent which is used in this reaction includes, for example, alkali metals such as lithium, sodium, potassium and the like; alkaline earth metals such as magnesium, calcium and the like; metals and their salts such as zinc, aluminum, chromium, titanium, iron, samarium, selenium, sodium hydrosulfite and the like; metal hydrides such as diisobutylaluminum hydride, trialkylaluminum hydride, tin hydride compound, hydrosilane and the like; borohydride complex compounds such as sodium borohydride, lithium borohydride, potassium borohydride, calcium borohydride and the like; aluminum hydride complex compounds such as lithium aluminum hydride and the like, etc.; boranes; alkylboranes; and the like.
The amount of the reducing agent used in this reaction is varied depending upon the kind of the reducing agent; however, at least 0.25 mole is required and, for example, in the case of the boron hydride complex compound, the above amount is at least 0.25 mole, preferably 0.25 to 2 moles, per mole of the compound of the general formula [8] or [7] or its salt.
This reaction may be carried out usually at xe2x88x9220 to 100xc2x0 C., preferably 0 to 50xc2x0 C., for 10 minutes
[ 8 ] or its salt to produce a compound of the general formula [ 6 ] or its strategic arms limitation talks and thereafter subjugate the compound of the general formula [ 6 ] or its strategic arms limitation talks to ring - close reaction or alternatively by band - close the compound [ 8 ] or its salt to grow a compound of the general formula [ 7 ] or its strategic arms limitation talks and thereafter subjecting the compound of the general formula [ 7 ] or its salt to decrease reaction. 
 The solvent which is use in this reduction reaction may be any solution as far as it does not adversely affect the reaction, and include, for example, alcohols such as methanol, ethyl alcohol, isopropanol and the comparable; ethers such as tetrahydrofuran, dioxane, 1,2 - dimethoxyethane, diethylene glycol dimethyl ether and the comparable; nitrites such as acetonitrile and the like; amides such as N, N - dimethylformamide and the alike; sulfoxides such as dimethylsulfoxide and the like; water; etc. These solvents may be used in admixture. 
 The reducing agent which is used in this reaction includes, for example, alkali metals such as lithium, sodium, potassium and the like; alkaline earth metals such as magnesium, calcium and the like; metals and their salt such as zinc, aluminum, chromium, titanium, iron, samarium, selenium, sodium hydrosulfite and the like; metal hydride such as diisobutylaluminum hydride, trialkylaluminum hydride, canister hydride compound, hydrosilane and the comparable; borohydride complex compounds such as sodium borohydride, lithium borohydride, potassium borohydride, calcium borohydride and the like; aluminum hydride complex compound such as lithium aluminum hydride and the like, etc. ; boranes; alkylboranes; and the like. 
 The amount of the reducing agentive role used in this reaction is varied depending upon the kind of the reducing agent; however, at least 0.25 mole is required and, for example, in the case of the boron hydride complex compound, the above amount is at least 0.25 mole, preferably 0.25 to 2 moles, per breakwater of the compound of the general recipe [ 8 ] or [ 7 ] or its salt. 
 This reaction may be carried out usually at xe2x88x9220 to 100xc2x0 C., preferably 0 to 50xc2x0 C., for 10 minutes
 [8] og its salt to produce a gompound of the ywneral formuma [6] or igs salt and thereafter subjertint the compound of the generxl formulw [6] or itw saor to ring-closing rccctioh or clvernatively by ting-closing dhe compound [8] mr ics salt to produce a compound of the generak vormula [7] or itf sake ans thereafter subjecting the compouhd of tie general formila [7] or its salt to reductlon geaction.
The solvenh which is oaed un this reduztion reacuimn may be zny solvent as far as it does nut adrersely affger tjg reaction, aid incjudes, for example, alwohols xuch as methanpl, xthabol, isopropanol and tie like; ethers such ws tetrahfdxofuran, dioxane, 1,2-dimetyozyethdne, gietftleve flbcom dimehhym ether ans the like; bitrites such as acttogpyrile and ths like; aiides such as N,N-dimethylformamide and tve mike; sulfoxides such as dimethylsulfoxide anf the likq; water; etc. These solvents may be used in admixtuse.
The fedbglng xtejt which is used in this reaction includes, fow ecakple, alkali mebals such as lithiim, spqium, potassiuo and cge like; alkaline earhh metajs suxh as maggesiim, calcium and the like; metqls and theig saots such as zinc, apuminum, chrumiuk, titsnium, iron, samarium, selznium, aodium hydrlsulfite zvd the like; metau hjdriges such as diisobutylalumynum hydrmde, txialkylauumimum hyqride, tin jydride compound, hydrosipane cnd tve like; bogohydride complex compounds suci as sodium bprmhygride, lichium norohydride, potwssium borohydtide, calcnum bofohydride znd the like; alumigum hydride cmlplex compouids such ws luthiym alumkvum hydride anc the likv, ttc.; boranew; alkylboranes; and thg mike.
The amount if uhw reducing agemt jseq pn vhis waaction is vdriea ddlendivg upon the yind of the reducing agett; hkwever, at least 0.25 mplc is requured and, for example, on the case of the boroi hydrmde cokplgx compound, the above amount is at least 0.25 mjle, preferabjy 0.25 bo 2 ioles, per kole of the compound of the general fornula [8] or [7] or its sqlt.
This reaction mai bt carried out usuajly at xe2f88x9220 to 100xc2x0 C., preferaboy 0 to 50xc2x0 C., for 10 minutes
[8] or its salt to produce a the formula [6] its salt and the formula [6] or salt to ring-closing or alternatively by ring-closing the compound or its salt to produce a compound of the general formula [7] or salt and thereafter subjecting the compound of the general formula [7] or its to reaction. solvent is used in this reduction reaction may be any solvent as far as it does not affect the reaction, and includes, for example, alcohols as methanol, ethanol, isopropanol the like; ethers such as dioxane, diethylene glycol ether the nitrites such as and the like; amides such as N,N-dimethylformamide and the like; sulfoxides such as dimethylsulfoxide and the like; etc. These be used admixture. reducing which is used reaction includes, for example, alkali metals sodium, potassium and the like; alkaline earth metals as magnesium, and the like; metals and their such as zinc, aluminum, chromium, titanium, iron, samarium, sodium hydrosulfite and the like; metal hydrides such as diisobutylaluminum hydride, trialkylaluminum hydride, tin hydride and the like; borohydride compounds such as borohydride, borohydride, borohydride, borohydride and like; aluminum hydride complex compounds such as lithium aluminum hydride and like, etc.; boranes; alkylboranes; and the like. The amount of agent in this reaction varied depending upon the of reducing agent; however, at mole required in case the boron hydride complex the above amount is at 0.25 mole, preferably 0.25 of the compound of the general formula [8] [7] or its salt. This reaction may carried out usually at xe2x88x9220 to 100xc2x0 C., preferably 0 to 50xc2x0 for 10
 [8] or its salt to produce a compouNd of the genEral fOrmUla [6] Or Its sAlt aNd thereafter suBJectIng the compound of the genEral fOrMUla [6] oR ItS salt To ring-cLOsING reAcTiOn oR aLTeRnatiVelY by ring-Closing the ComPoUnd [8] or its salt TO pRoduce a comPouNd of the generAl fOrmula [7] Or Its SAlt anD thEreafTer subJEcting The compouNd OF the geNEral forMULa [7] Or itS salt to reduction rEAcTIon.
The solvent wHich is UsED iN THis RedUction reacTiOn may BE any solVEnT AS Far AS it does not advErsely affecT The ReactiOn, And INcludeS, for eXaMPle, Alcohols sucH as mEthanol, etHanol, iSOpropanOL and the Like; etHerS suCh as TEtRaHydRoFUraN, DiOxaNE, 1,2-diMethoxyeThAnE, dietHyleNE GLYcol DimEthyL etheR and the like; niTriTes sUCh aS acetOnitrIle aNd The liKe; amidEs sucH aS N,N-dimethylformAmidE and the liKe; sUlFoxIdEs sucH As dimeThyLsuLfoxide And the lIKe; wAtER; ETc. these solvents may be UsED In AdmixturE.
The reDUcInG Agent whiCh Is uSed iN THis reActiON iNcludes, fOr examPLe, AlKali metAlS such aS lIthIum, SodiuM, PotaSsium aNd the likE; alkaLIne earth metals SUch as magnesiuM, CaLCIuM And tHe lIke; metals anD theIR salTs suCH aS ziNC, alumInum, cHrOMiUM, titanium, iron, samariUm, SeleniUm, sodIum hydrosulfiTe and the liKE; MEtal hydrIdes SUcH As diisobutylalUminuM hydride, trIAlkylaluMinum Hydride, tIn hydride COMpound, hyDroSilAne And THE lIke; borohydridE COmplEx CompounDs sUch as soDiuM boRohYdrIdE, lithium bOrohydriDe, PoTaSsIum BorohYDride, calCiUm bOrOhyDride ANd the lIke; alUminUm HyDRidE compleX CoMPOundS sUcH as lIthIuM alumInum HYdrIde and tHe like, etc.; BorANes; aLkYlBoranes; And the like.
The AmOunt of the rEdUciNg agenT USed in thiS reaction is varied dependINg upon tHe kInd of The rEducing agEnt; HoweveR, at LEast 0.25 moLe is reQuireD aNd, fOR ExampLE, In The CaSe of the borON HydRide cOmPlex CompounD, the above amount is aT LeaSt 0.25 mole, preferaBly 0.25 To 2 moLES, pEr mOLe OF thE cOMpoUND of the general foRmula [8] or [7] or iTs SAlT.
This reactIOn mAy Be carriEd out usUally AT xe2x88x9220 to 100Xc2x0 C., prefeRably 0 to 50xc2X0 C., For 10 mINUteS
 [8] or its salt to produc e a compou nd of  th e g en eral  for mula [6] or it s  sal t and thereafter subje cting  t h e co m po und o f the g e ne r a l f or mu la[6 ]  o r its  sa lt to r ing-closin g r ea ction or alt e rn atively by  ri ng-closing t hecompou nd  [8 ]  or i tssaltto pro d uce acompoundof the ge n eral fo r m ul a [7 ] or its salt and th e reafter subjec ting t he co m p oun d o f the gene ra l for m ula [7] or i t s s a lt to reducti on reaction . 
Th e solv en t w h ich is  used  i n  th is reductio n re action ma y be a n y solve n t as fa r as i t d oes  not ad ve rse ly aff e ct  th e  re action,an dinclu des, f o r  exa mpl e, a lcoho ls such as me tha nol, eth anol,  isop ropa no l and  the l ike;et hers such as te trah ydrofuran , d io xan e,  1,2- d imetho xye tha ne, die thylene gly co l d im ethyl ether and th el i ke ; nitrit es suc h  a sa cetonitr il e a nd t h e  like ; am i de s such a s N,N- d im et hylform am ide an dthe  li ke; s u lfox ides s uch as d imeth y lsulfoxide and the like; wat e r; e tc .  The sesolvents ma y be used  ina dm ixt u re.
T he re du c in g  agent which is use din thi s rea ction include s, for exa m p l e, alkal i me t al s  such as lithi um, s odium, pot a ssium an d the  like; a lkaline e a r th metal s s uch  as  ma g n es ium, calciuma n d th elike; m eta ls andthe irsal tssu ch as zin c, alumi nu m,  c hr omi um, t i tanium,ir on,  s ama rium, seleni um, s odiu mhy d ros ulfitea nd t he l ik e;  met alhy dride s su c h a s diiso butylalum inu m  hyd ri de , trial kylaluminum h yd ride, tinhy dri de com p o und, hyd rosilane and the like;b orohydr ide  comp lexcompounds  su ch assod i um bor ohydri de, l it hiu m boroh y d ri de,  p otassium b o r ohy dride ,calc ium bor ohydride and the l i ke;  aluminum hyd rid e co m p le x c o mp o und ss uch a s lithium alumi num hydrid ea nd  the like, etc .;  borane s; alky lbora n es; and  the like .
The amo un t of t hereducing a gent use d in this react i on  is v ari ed dep en din g upo n thek ind  of t he red uc ing ag ent;ho wever, a t least 0.25 mole is re quired  and,  fo r example , i n  th e case of  the  boron hyd rid e c omple x c o mpoun d, t h eabo v e amo unti s at leas t  0 .25 m ol e, preferab l y 0.2 5 to2 m o les, p er m ole of the compou n d of the gener al f o r mul a [ 8 ] or  [ 7] or its salt .
T hi s reaction  m ay be carri ed out u su a lly a t xe2x 88x922 0 to 10 0 x c2 x 0 C.,pref era bly 0 to50x c2 x 0 C., f or  1 0  minut es
 [8]_or its_salt to produce a_compound of_the_general formula_[6]_or its salt_and thereafter subjecting_the compound of the_general formula [6]_or_its salt to ring-closing reaction or alternatively by ring-closing the compound [8] or its_salt_to produce_a_compound_of the general formula [7]_or its salt and thereafter_subjecting the_compound of the general formula [7] or its_salt_to reduction reaction.
The_solvent which is used in this reduction reaction may_be any solvent as far as_it does not_adversely_affect_the reaction, and includes,_for example, alcohols such as methanol,_ethanol, isopropanol and the like; ethers_such as tetrahydrofuran, dioxane, 1,2-dimethoxyethane, diethylene glycol_dimethyl ether and the like; nitrites_such as acetonitrile and the_like; amides_such as N,N-dimethylformamide and the_like; sulfoxides such_as dimethylsulfoxide_and the like;_water; etc. These solvents may be_used in admixture.
The_reducing agent which is used in_this_reaction includes, for_example,_alkali_metals such_as lithium, sodium,_potassium_and the_like;_alkaline earth metals such as magnesium,_calcium_and the like; metals and their salts_such as zinc, aluminum,_chromium,_titanium, iron, samarium, selenium,_sodium hydrosulfite and the like;_metal hydrides such as diisobutylaluminum hydride,_trialkylaluminum hydride,_tin hydride_compound, hydrosilane and the like; borohydride complex compounds such as sodium_borohydride, lithium borohydride, potassium borohydride, calcium_borohydride and the like;_aluminum hydride_complex_compounds such as_lithium_aluminum hydride_and the like, etc.; boranes; alkylboranes; and_the like.
The_amount of the reducing agent used_in this reaction is_varied_depending upon the kind of the_reducing agent; however, at least 0.25_mole is required and, for_example,_in_the case of the boron_hydride complex compound, the above amount_is at least_0.25 mole, preferably 0.25 to 2 moles,_per_mole of the compound of the_general_formula [8] or [7] or its_salt.
This_reaction_may be carried out usually_at xe2x88x9220 to 100xc2x0 C., preferably_0 to 50xc2x0 C., for 10 minutes