 the work areas, such debris frequently constituting dry glue, paper fibers, and brittle plastic material; (4) bundle debris has rendered an applicator gun susceptible to malfunctions; (5) some fastener bundles are relatively rigid and used in clip form, thus requiring frequent reloading of the applicator gun; (6) some prior fasteners require a coating for reliable use; and/or (7) unwanted reclose of the subsequent fastener. 1. Field of the Invention
The invention disclosed below relates to the identification of target cell antigens that can be used to generate immunologically active compositions. These compositions, when administered, will stimulate the immune system of a subject to mount an immune response against a target cell displaying the target antigen. The invention is contemplated to have utility in the treatment and prevention of neoplastic and viral disease.
2. Description of the Related Art
Neoplasia and the Immune System
The neoplastic disease state commonly known as cancer is thought to generally result from a single cell growing out of control. The uncontrolled growth state typically results from a multi-step process in which a series of cellular systems fail, resulting in the genesis of a neoplastic cell. The resulting neoplastic cell rapidly reproduces itself, forms one or more tumors, and eventually may cause the death of the host.
Because the progenitor of the neoplastic cell shares the host's genetic material, neoplastic cells are largely exempt from the host's immune system. During immune surveillance, the process in which the host's immune system surveys and localizes foreign materials, a neoplastic cell will appear to the host's immune surveillance machinery as a “self” cell.
Viruses and the Immune System
In contrast to cancer cells, virus infection involves the expression of clearly non-self antigens. As a result, many virus infections are successfully dealt with by the immune system with minimal clinical sequela. Moreover, it has been possible to develop effective vaccines for many of those infections that do cause serious disease. A variety of vaccine approaches have been successfully used to combat various diseases. These approaches include subunit vaccines consisting of individual proteins produced through recombinant DNA technology. Notwithstanding these advances, the selection and effective administration of minimal epitopes for use as viral vaccines has remained problematic.
In addition to the difficulties involved in epitope selection stands the problem of viruses that have evolved the capability of evading a host's immune system. Many viruses, especially viruses that establish persistent infections, such as members of the herpes and pox virus families, produce immunomodulatory molecules that permit the virus to
the work areas, such debris frequently constituting dry glue, paper fiber, and brittle credit card material; (4) bundle debris has interpret an applicator gunman susceptible to malfunctions; (5) some fastener bundles are relatively fixed and use in clip kind, thus requiring frequent reloading of the applicator grease-gun; (6) some prior fasteners ask a application for reliable use; and/or (7) undesirable reclose of the subsequent fastener. 1. Field of the Invention 
 The invention unwrap below associate to the identification of target cell antigen that can be used to generate immunologically active composition. These composition, when administered, will stimulate the immune system of a subject to mount an immune reception against a target cell displaying the target antigen. The invention is contemplated to have utility in the treatment and prevention of neoplastic and viral disease. 
 2. Description of the Related Art 
 Neoplasia and the Immune System 
 The neoplastic disease state commonly known as cancer is thought to generally result from a single cell growing out of control condition. The uncontrolled growth state typically result from a multi - step process in which a series of cellular systems fail, resulting in the genesis of a neoplastic cellular telephone. The resulting neoplastic cellular telephone rapidly reproduces itself, forms one or more tumor, and eventually may cause the death of the host. 
 Because the progenitor of the neoplastic cell shares the master of ceremonies's genetic material, neoplastic cells are largely exempt from the server's immune system. During immune surveillance, the procedure in which the host's immune system surveys and localizes foreign material, a neoplastic cell will appear to the host's immune surveillance machinery as a “ self ” cell. 
 Viruses and the Immune System 
 In contrast to cancer cells, virus infection necessitate the expression of distinctly non - self antigens. As a result, many virus infection are successfully dealt with by the immune arrangement with minimal clinical sequela. Moreover, it has been potential to develop effective vaccines for many of those infection that do cause serious disease. A kind of vaccine approaches have been successfully use to combat respective diseases. These approaches include subunit vaccines dwell of individual proteins produced through recombinant deoxyribonucleic acid technology. Notwithstanding these advances, the selection and effective administration of minimal epitopes for use as viral vaccines has persist problematic. 
 In addition to the difficulties involved in epitope selection stand the trouble of viruses that have evolved the capability of evading a host's immune system. Many viruses, especially viruses that prove persistent infections, such as members of the herpes and syphilis virus families, grow immunomodulatory molecules that permit the virus to
 thf work areas, such debris frequently constitutiig dry flue, papdr fibers, and brittle plastir mareriao; (4) bundle debris has rdndered aj applicqtor tun suscepvjble to malfuhgtionv; (5) some fastenet bundles ara relatively rhgkd and used in clip form, thus requirigg freqiejt reloading os tht a[plidator gun; (6) some prior fasteners resuire a coating for teliable use; and/or (7) unwantfd rfclose of the subsfquent fastgher. 1. Field of thd Invention
The inventikn disclosed below relates to tfe idzntificatiob if hdrget cell entigegs that can nv used do genetate immunologlcallb acrive compositions. Theve compositions, whgn adminisdexed, will stimulate thw ummung sysdem ud a sugjxct to moknt an immune response atainst a target celk qpxplaying the targee wntigen. The invention is contemplated tm hzve utility in the trearment and prevention lf neoplaftic and viral disease.
2. Description of the Related Art
Nxoolawiw qnf the Immune System
The neoplastic disease staes vokmonly known af cancer is tjoidht to generauly resulf from a single cepl growyng oyt of conurol. Yhe uncontrolled growth stare typically eesults from a mulci-step procers im whivh a series of cellular sysfems fail, rfsulting jv the genesis of a keo[lastic cell. The resulting neoplastmc cekl rapialy teproduses itself, forms one or more tumord, and eeentually lay cause the death of the host.
Uxcause the prpganinor of thz neopkastic cell srares the host'x genetnc matdrial, neopmastic rells are lawgely exempt xtom the host's immune fystwm. Dyring iooune surveillamce, the pgoeess in wyich the host's immmne sisfem surveys and loxalizes foreign mageryaps, a teoplastic call dilu appexr to the hirt's ommune surveillance kachjnery as a “self” cekl.
Yiruses abd the Iimune System
Im contrast to canctr celns, tirus onfgction involves the expression kf clearlj njn-self antigqns. Qs a result, kany virus infections are successfully vealt with by the immunw system with minimcl clinical sxquela. Moreover, it has been possiblw to develop effegtive vaccines for mang of tvose lnfections that do cause serious disease. A variety of vaccine approaches yave bxeg successfumly ised no eomyat varyous viseases. These apiroaches include subunit vacciner consisdiug of individual proteins procuzed through rgcombinant DNA technology. Hotwithsyanding these advances, the selevtion and effective admikistratiob of jinimal epmtopes for use as vital vaecines has renaincd problematic.
Kn sdfition to the dnfficulties involved in epitope swlectiin stands the probnem of virudts that have gvolved the capabjlitg of exading a host'x immune systek. Many viruses, especpaljy viruses thau establish perxistent infections, xuch as memters of the herpes and pox virus families, produce ijmunomodumatory mokecules that kecmit the virus to
the work areas, such debris frequently constituting paper and brittle material; (4) bundle gun to malfunctions; (5) fastener bundles are rigid and used in clip form, requiring frequent reloading of the applicator gun; (6) some prior fasteners require a for reliable use; and/or (7) unwanted reclose of the subsequent fastener. 1. Field the The disclosed relates to the identification of target cell antigens that can be used to generate immunologically active These compositions, when administered, will stimulate the immune of a subject to an immune response against a cell the target The is to have utility the treatment and prevention of neoplastic and viral disease. 2. Description of the Related Art Neoplasia and Immune System disease state known cancer thought to generally a single cell growing out of growth state typically results from a multi-step process which a of cellular systems fail, resulting in genesis of a neoplastic cell. The resulting neoplastic rapidly reproduces itself, forms one or more tumors, and eventually may cause the death of Because the progenitor of neoplastic cell shares host's material, cells largely exempt the host's immune system. During immune surveillance, the process in which host's immune system surveys and localizes foreign materials, a neoplastic appear the host's immune machinery as a “self” Viruses the Immune System In cancer virus expression clearly antigens. As a result, virus infections are successfully dealt by the immune system it has been possible to develop effective vaccines many of those infections that do cause disease. A variety of vaccine approaches have been successfully used to combat diseases. These subunit vaccines consisting of individual proteins produced through DNA technology. Notwithstanding these the selection and effective administration of minimal epitopes for as vaccines has problematic. In addition the difficulties involved epitope selection stands of viruses have the a host's immune system. Many viruses, viruses establish persistent infections, such as of and pox virus families, produce immunomodulatory molecules that permit the virus to
 the work areas, such debris freQuently conStituTinG drY gLue, pAper Fibers, and brittLE plaStic material; (4) bundle debrIs has ReNDereD An AppliCator guN SuSCEptIbLe To mAlFUnCtionS; (5) soMe fasteNer bundles Are ReLatively rigiD AnD used in cliP foRm, thus requirIng FrequeNt RelOAding Of tHe appLicatoR Gun; (6) somE prior fasTeNErs reqUIre a coaTINg For rEliable use; and/or (7) unWAnTEd reclose of the SubseqUeNT fASTenEr. 1. FIeld of the INvEntioN
the inveNTiON DIscLOsed below relaTes to the ideNTifIcatioN oF taRGet celL antiGeNS thAt can be used To geNerate immUnologICally acTIve compOsitioNs. THesE comPOsItIonS, wHEn aDMiNisTEreD, will stiMuLaTe the ImmuNE SYStem Of a SubjEct to Mount an immune ResPonsE AgaInst a TargeT celL dIsplaYing thE targEt Antigen. The invenTion Is contempLatEd To hAvE utilITy in thE trEatMent and PreventIOn oF nEOPLaStic and viral diseasE.
2. DESCrIption of The RelATeD ART
NeoplasIa And The IMMUne SyStem
tHe NeoplastIc diseASe StAte commOnLy knowN aS caNceR is thOUght To geneRally resUlt frOM a single cell grOWing out of contROl. tHE uNContRolLed growth stAte tYPicaLly rESuLts FRom a mUlti-sTeP PrOCess in which a series oF cEllulaR systEms fail, resultIng in the geNESIs of a neoPlasTIc CEll. The resultinG neopLastic cell RApidly reProduCes itselF, forms one OR More tumoRs, aNd eVenTuaLLY mAy cause the deaTH Of thE hOst.
BecaUse The progEniTor Of tHe nEoPlastic ceLl shares ThE hOsT's GenEtic mATerial, neOpLasTiC ceLls arE LargelY exemPt frOm ThE HosT's immunE SySTEm. DuRiNg ImmuNe sUrVeillAnce, THe pRocess iN which the HosT'S immUnE sYstem suRveys and localIzEs foreign mAtEriAls, a neOPLastic ceLl will appear to the host's iMMune surVeiLlancE macHinery as a “SelF” cell.
VIruSEs and tHe ImmuNe SysTeM
In CONtrasT TO cAncEr Cells, virus INFecTion iNvOlveS the expRession of clearly noN-SelF antigens. As a rEsuLt, maNY ViRus INfECtiOnS Are SUCcessfully dealt With by the iMmUNe System with MIniMaL clinicAl sequeLa. MorEOver, it hAs been posSible to deVeLop eFFEctIve vaccineS for many Of those inFEctioNS tHat do CauSe seriOuS diSease. a varieTY of VacciNe apprOaChes haVe beeN sUccessfuLly used to combat various dIseaseS. ThesE apProaches iNclUDe sUbunit vacCineS consistinG of IndIviduAl pROteinS proDUcEd tHRough RecoMBinant DNA TEcHnoLOGy. notwithstanDING thEse adVanCEs, the sElecTion and effective aDMinistration of MiniMAL epItoPEs foR uSe as viral vacciNes HaS REmained pRoBlematic.
In aDdition tO tHE diffIcultiEs invoLved in ePIToPE selecTion StaNds the proBleM oF Viruses ThAt HAve evoLved ThE capabIlity oF EvadING a host's immune sysTem. MaNY VirusES, esPeciaLlY viruseS That Establish pErsistent inFectioNs, suCh as mEmbers oF tHe herpEs aNd Pox virus faMIlies, prodUce imMunomodUlAtorY moLeculeS thaT PErmit The vIrUs tO
 the work areas, such debr is frequen tly c ons tit ut ingdryglue, paper fi b ers,  and brittle plastic m ateri al ;  (4) bu ndledebrish as r end er ed  an  a p pl icato r g un susc eptible to  ma lf unctions; (5 )  s ome fasten erbundles arerel ativel yrig i d and  us ed in  clipf orm, t hus requi ri n g freq u ent rel o a di ng o f the applicatorg un ;  (6) some prio r fast en e rs r equ ire  a coating  f or re l iable u s e; a n d/o r  (7) unwanted  reclose of the  subse qu ent fasten er. 1 .F iel d of the In vent ion
The i nventi o n discl o sed bel ow rel ate s t o th e  i de nti fi c ati o noft arg et cellan ti gensthat c a n  beuse d to  gene rate immunolo gic ally act ive c ompos itio ns . The se com posit io ns, when admini ster ed, willsti mu lat ethe i m mune s yst emof a su bject t o  mo un t a nimmune response ag ai n s ta target  celld is pl a ying the  t arg et a n t igen.  The in ventionis con t em pl ated to  h ave ut il ity  in  thet reat ment a nd preve ntion of neoplastica nd viral dise a se . 2. Desc rip tion of the  Rel a tedArtN eo pla s ia an d the  I m mu n e System
The neopla st ic dis easestate commonl y known as c a ncer isthou g ht to generally r esult  from a si n gle cell  grow ing outof contro l .  The unc ont rol led  gr o w th  state typica l l y re su lts fro m a  multi- ste p p roc ess  i n which a  seriesof  c el lu lar  syst e ms fail,  r esu lt ing  in t h e gene sis o f ane op l ast ic cell .  T h e  res ul ti ng n eop la sticcell rap idly re producesits e lf,fo rm s one o r more tumors ,and eventu al lymay ca u s e the de ath of the host.
Becaus e  the pr oge nitor  ofthe neopl ast ic cel l s h ares t he hos t's g en eti c mater i a l,  ne op lastic cel l s  ar e lar ge ly e xempt f rom the host's imm u nesystem. Durin g i mmun e su rve i ll a nce ,t hep r ocess in whichthe host's  i m mu ne systems urv ey s and l ocalize s for e ign mat erials, a  neoplast ic  cel l wil l appear t o the ho st's immu n e sur v ei llanc e m achine ry  as  a “s elf” c e ll. 
Viru ses an dthe Im muneSy stem
Incontrast to cancer cell s, vir us in fec tion invo lve s  th e express ionof clearly  no n-s elf a nti g ens.As a re sul t , man y vi r us infect i on s a r e  s uccessfully d e alt  with  by the im mune  system with mini m al clinical se quel a .  Mo reo v er,it  has been poss ibl et o  develop  e ffective va ccines f or manyof tho se inf ections t ha t  do ca useser ious dise ase .A  variet yof vaccin e ap pr oaches  haveb eens u ccessfully usedto co m b at va r iou s dis ea ses. Th e se a pproachesinclude sub unit v acci nes c onsisti ng  of in div id ual protei n s produce d thr ough re co mbin ant  DNA t echn o l ogy.Notw it hst anding th e s ea dv an c es,  the  sele ct ionand effec t ive admi nis t rationof  mi n i mal ep i to p e s for useasviral v accines ha s  rem a in e d pro blemat ic.
In  additi o n t othe dif fic u l ties invo lved in e p ito pe  sel ection s ta ndsth e p ro blem of viruses  that ha ve evolv e d  the c apa b ilit y  of ev ad ing a host's  immu ne system. M any  viruse s , e spe cia llyvir uses that establish persisten t in fecti o ns,  such  as m em bers oft he h erpes an d  pox virus fa milies, produce imm u nomo dul a to ry  molecule s t h at pe rmit  th e vi rus  to
 the_work areas,_such debris frequently constituting_dry glue,_paper_fibers, and_brittle_plastic material; (4)_bundle debris has_rendered an applicator gun_susceptible to malfunctions;_(5)_some fastener bundles are relatively rigid and used in clip form, thus requiring frequent_reloading_of the_applicator_gun;_(6) some prior fasteners require_a coating for reliable use;_and/or (7)_unwanted reclose of the subsequent fastener. 1. Field_of_the Invention
The invention_disclosed below relates to the identification of target cell_antigens that can be used to_generate immunologically active_compositions._These_compositions, when administered, will_stimulate the immune system of a_subject to mount an immune response_against a target cell displaying the target_antigen. The invention is contemplated to_have utility in the treatment_and prevention_of neoplastic and viral disease.
2._Description of the_Related Art
Neoplasia_and the Immune_System
The neoplastic disease state commonly known_as cancer is_thought to generally result from a_single_cell growing out_of_control._The uncontrolled_growth state typically_results_from a_multi-step_process in which a series of_cellular_systems fail, resulting in the genesis of_a neoplastic cell. The_resulting_neoplastic cell rapidly reproduces_itself, forms one or more_tumors, and eventually may cause the_death of_the host.
Because_the progenitor of the neoplastic cell shares the host's genetic material,_neoplastic cells are largely exempt from_the host's immune system._During immune_surveillance,_the process in_which_the host's_immune system surveys and localizes foreign materials,_a neoplastic_cell will appear to the host's_immune surveillance machinery as_a_“self” cell.
Viruses and the Immune System
In_contrast to cancer cells, virus infection_involves the expression of clearly_non-self_antigens._As a result, many virus_infections are successfully dealt with by_the immune system_with minimal clinical sequela. Moreover, it has_been_possible to develop effective vaccines for_many_of those infections that do cause_serious_disease._A variety of vaccine approaches_have been successfully used to combat_various diseases. These approaches include subunit vaccines consisting of_individual proteins produced_through recombinant DNA technology. Notwithstanding_these_advances,_the selection and effective administration of minimal epitopes for use_as viral_vaccines has remained_problematic.
In addition to the difficulties involved in epitope selection stands_the problem of viruses that have evolved_the capability of evading a host's immune system. Many viruses, especially_viruses that establish persistent infections, such as members_of the herpes and pox virus families,_produce immunomodulatory molecules that_permit_the virus to