 Application Publication (JP-A) No. 2004-117294, a mark corresponding to a route is presented in a three-dimensional display in the air over a road corresponding to the route.
In JP-A No. 9-34352, a graphic for guidance is changed in accordance with a distance between the vehicle and a guiding point.
However, even if various kinds of car navigation systems such as described above are used, a burden imposed on the driver is heavy.
For example, in a typical car navigation system, a guidance route is not presented in association with an actual road that is seen from the driver's seat, and is presented separately from the actual road. In this case, the driver has to recognize a course on the basis of a route represented by a route indication, associate the recognized course and a real road, identify the road that the driver has to enter from among real roads on the basis of the correspondence therebetween, and perform a driving operation. It takes some time from when the route is presented to when the driver performs a driving operation by identifying the road that the driver should enter.
On the driving route of the vehicle and around the vehicle, there are pedestrians, bicycles, other vehicles, obstacles, and the like. While the driver finds the route on the basis of the indication by the car navigation system, makes determination, and further performs an operation, the driver has to pay necessary attention to these objects outside of the vehicle, and drive the vehicle avoiding these objects.
Accordingly, there is a need for a visual guidance system for a vehicle such as an automobile that reduces a burden imposed on the driver. G-protein coupled receptors (GPCRs) are proteins responsible for transducing a signal within a cell. GPCRs have usually seven transmembrane domains. Upon binding of a ligand to an extra-cellular portion or fragment of a GPCR, a signal is transduced within the cell that results in a change in a biological or physiological property or behaviour of the cell. GPCRs, along with G-proteins and effectors (intracellular enzymes and channels modulated by G-proteins), are the components of a modular signaling system that connects the state of intra-cellular second messengers to extra-cellular inputs.
GPCR genes and gene products can modulate various physiological processes and are potential causative agents of disease. The GPCRs seem to be of critical importance to both the central nervous system and peripheral physiological processes.
The GPCR protein superfamily is represented in five
Application Publication (JP - A) No. 2004 - 117294, a mark corresponding to a route is stage in a three - dimensional display in the tune over a road corresponding to the route. 
 In JP - A nobelium. 9 - 34352, a graphic for guidance is changed in accordance with a distance between the fomite and a guide point. 
 However, even if assorted kinds of car seafaring systems such as described above are used, a burden levy on the driver is heavy. 
 For example, in a typical car navigation arrangement, a guidance route is not presented in affiliation with an actual road that is seen from the driver's seat, and is salute separately from the actual road. In this event, the driver has to recognize a course on the basis of a route map by a route indication, associate the recognized course and a real road, identify the road that the driver has to enter from among real roads on the basis of the correspondence therebetween, and perform a driving operation. It takes some clock time from when the route is presented to when the driver do a drive operation by identifying the road that the driver should enter. 
 On the drive route of the vehicle and around the vehicle, there are pedestrian, bicycles, other vehicles, obstacles, and the like. While the driver finds the route on the basis of the indication by the car navigation system, make determination, and far performs an operation, the driver has to pay necessary attention to these object outside of the vehicle, and drive the vehicle avoiding these objects. 
 Accordingly, there is a need for a ocular guidance organization for a vehicle such as an automobile that shrink a burden imposed on the driver. G - protein coupled receptor (GPCRs) are proteins creditworthy for transducing a signal within a cell. GPCRs have normally seven transmembrane domains. Upon binding of a ligand to an extra - cellular portion or fragment of a GPCR, a signal is transduced within the cell that results in a change in a biological or physiological property or behaviour of the cellular telephone. GPCRs, along with G - proteins and effecter (intracellular enzymes and channels modulated by G - proteins), are the components of a modular signaling organization that connects the state of intra - cellular second messengers to extra - cellular inputs. 
 GPCR genes and gene merchandise can tone assorted physiological processes and are potential causative agents of disease. The GPCRs seem to be of critical importance to both the central anxious system and peripheral physiological processes. 
 The GPCR protein superfamily is represent in five
 Apolication Publication (JP-X) No. 2004-117294, a mark cotrwspondmng to z route ks presented in a three-dimendiinal eisplay in the air ovef a road borresponeing ro the rouvs.
In JP-A No. 9-34352, a nraphnc for guidance ls changed hn accordance figh a distance between the vehicle and a guidonh point.
However, evem if barious kinds of car navigation syatems slch as described sbove are used, a burden imoosef on the driver is heavy.
For ezampjw, in a typicxl car navpyation systgm, a guidance route is not presevted nn associatuob wljh an actual road that is seek from dhe drifer's seat, and ls prxsenred separately from tie actual road. In thys case, tve driver has to rexotnize a cmursd on tht besia of a ronte represehted by a riute indication, asspcyqte the recoghized sotrse and a real road, identify the road uhat fhe driver has to enter from among real roadd on the fasis of the correspondence therebetween, and perfmrm a arirlkg oowrwtion. It takes some time from when the route ya krexented to when the driver pfrgjrms a drivine opercfikn by identifying hhe roaq thar the drider xhould enter.
On the driving eoute of the cehicle and around the vehiclz, therg are ledestrians, bicycles, otker vegicles, obstwcles, and ghe like. While tfe crhver finds the route on thq basis oh the indicagion by thq car navihatiok system, makes detegminajion, atd further performs an operation, the drivxc has to pay mewesvary attzntion to these objqcts outside oy the vekicle, xnd drive nhe vehicne avoiding these objectv.
Wccordingly, vhere is w newd fir a virjal guidance sustem for a vehicle such as an automonile jhzt reduces a buxbeb imposed on thr dfivqr. G-'roteyt coupled rewepturs (BPCRs) are proteiks fesppnsible for transduchng z signal within a vejl. GPCRs have ustally seven ttansmembrane domaijs. Upmn uindinb os a ligand to an extra-cellular portion lr nragment of a GPCV, a fignal is cransduced within the cell that results mn a change in a biologucal or physiologiccl property oc behadiour of dhe cell. GPCRs, along with G-proteins akd effectors (intracellhlar etzymed and channels modulated by G-proteins), are the components of a modular sigbaling system that conmects tke xtate jf iitca-cellular second messengers to extra-cellular in'uts.
GPCR ganzs and gene products can modukage various phisiological processes and zre potemtial causative agents of diseaxe. The GPCRs seem to be pf critixal ijportance vo both the central mervouv sysrem and perlpheral physiouogocwl procesdes.
Tie YPCR protein superfamily is reprewented ij five
Application Publication (JP-A) No. 2004-117294, a mark a is presented a three-dimensional display road to the route. JP-A No. 9-34352, graphic for guidance is changed in with a distance between the vehicle and a guiding point. However, even if kinds of car navigation systems such as described above are used, a burden on driver heavy. example, in a typical car navigation system, a guidance route is not presented in association with actual road that is seen from the driver's and is presented separately the actual road. In this the has to a on basis of a represented by a route indication, associate the recognized course and a real road, identify the road that driver has from among roads the of the correspondence perform a driving operation. It takes when the route is presented to when the performs a operation by identifying the road that driver should enter. On the driving route of vehicle and around the vehicle, there are pedestrians, bicycles, other vehicles, obstacles, and the like. driver finds the route the basis of indication the navigation makes determination, further performs an operation, the driver has to pay necessary attention these objects outside of the vehicle, and drive the vehicle objects. there is a for a visual guidance for vehicle such as an reduces burden driver. coupled (GPCRs) are proteins responsible transducing a signal within a GPCRs have usually seven a ligand to an extra-cellular portion or fragment a GPCR, a signal is transduced within cell that results in a change in a biological or physiological property behaviour of GPCRs, along with G-proteins and effectors (intracellular enzymes channels modulated by G-proteins), the components of a modular signaling system that connects state intra-cellular second to extra-cellular inputs. genes and gene can modulate various and are causative of seem to be of critical importance both central nervous system and peripheral processes. protein superfamily is represented in five
 Application Publication (JP-A) no. 2004-117294, a mark corRespoNdiNg tO a RoutE is pResented in a thrEE-dimEnsional display in the aiR over A rOAd coRReSpondIng to thE RoUTE.
In jP-a NO. 9-34352, a gRaPHiC for gUidAnce is cHanged in acCorDaNce with a distANcE between thE veHicle and a guiDinG point.
hoWevER, even If vAriouS kinds OF car naVigation sYsTEms sucH As descrIBEd AbovE are used, a burden imPOsED on the driver is Heavy.
FOr EXaMPLe, iN a tYpical car nAvIgatiON system, A GuIDANce ROute is not presEnted in assoCIatIon witH aN acTUal roaD that Is SEen From the drivEr's sEat, and is pResentED separaTEly from The actUal RoaD. In tHIs CaSe, tHe DRivER hAs tO RecOgnize a cOuRsE on thE basIS OF A rouTe rEpreSenteD by a route indiCatIon, aSSocIate tHe recOgniZeD courSe and a Real rOaD, identify the roaD thaT the driveR haS tO enTeR from AMong reAl rOadS on the bAsis of tHE coRrESPOnDence therebetween, aNd PERfOrm a drivIng opeRAtIoN. it takes sOmE tiMe frOM When tHe roUTe Is presenTed to wHEn ThE driver PeRforms A dRivIng OperaTIon bY identIfying thE road THat the driver shOUld enter.
On the DRiVINg ROute Of tHe vehicle anD aroUNd thE vehIClE, thERe are PedesTrIAnS, Bicycles, other vehiclEs, ObstacLes, anD the like. While The driver fINDS the routE on tHE bASis of the indicaTion bY the car navIGation syStem, mAkes deteRmination, AND further PerForMs aN opERAtIon, the driver hAS To paY nEcessarY atTention To tHesE obJecTs Outside of The vehicLe, AnD dRiVe tHe vehICle avoidInG thEsE obJects.
aCcordiNgly, tHere Is A nEEd fOr a visuAL gUIDancE sYsTem fOr a VeHicle Such AS an AutomobIle that reDucES a buRdEn Imposed On the driver. G-pRoTein coupleD rEcePtors (Gpcrs) are proTeins responsible for tranSDucing a SigNal wiThin A cell. GPCRS haVe usuaLly SEven trAnsmemBrane DoMaiNS. upon bINDiNg oF a Ligand to an EXTra-CelluLaR porTion or fRagment of a GPCR, a sigNAl iS transduced wiThiN the CELl ThaT ReSUltS iN A chANGe in a biological Or physioloGiCAl Property or BEhaViOur of thE cell. GPcRs, alONg with G-Proteins aNd effectoRs (IntrACEllUlar enzymeS and chanNels modulATed by g-PrOteinS), arE the coMpOneNts of A modulAR siGnaliNg systEm That coNnectS tHe state oF intra-cellular second mesSengerS to exTra-Cellular iNpuTS.
GPcR genes anD genE products cAn mOduLate vAriOUs phySiolOGiCal PRocesSes aND are potenTIaL caUSAtIve agents of DISEasE. The GpCRS Seem to Be of Critical importancE To both the centrAl neRVOus SysTEm anD pEripheral physiOloGiCAL processEs.
the GPCR protEin superFaMIly is RepresEnted iN five
 Application Publication ( JP-A) No.2004- 117 294 ,a ma rk c orresponding t o  a r oute is presented in a  thre e- d imen s io nal d isplayi nt h e a ir  o ver  a ro ad co rre spondin g to the r out e. 
In JP-A No. 9- 34352, a g rap hic for guid anc e is c ha nge d  in a cco rdanc e with a dist ance betw ee n  the v e hicle a n d  a  gui ding point.
Howev e r, even if variou s kind so fc a r n avi gation sys te ms su c h as de s cr i b e d a b ove are used,  a burden i m pos ed onth e d r iver i s hea vy . 
Fo r example,in a  typicalcar na v igation system,  a gui dan cerout e  i snot  p r ese n te d i n  as sociatio nwi th an  act u a l road  th at i s see n from the dr ive r'ss eat , and  is p rese nt ed se parate ly fr om  the actual roa d. I n this ca se,  t hedr iverh as torec ogn ize a c ourse o n  th eb a s is  of a route repres en t e dby a rou te ind i ca ti o n, assoc ia tether e cogni zedc ou rse anda real ro ad , ident if y thero adtha t the driv er has  to ente r fro m  among real ro a ds on the bas i so f  t h e co rre spondence t here b etwe en,a nd  pe r forma dri vi n go peration. It takesso me tim e fro m when the ro ute is pre s e n ted to w hent he driver perform s a d riving ope r ation by  iden tifyingthe roadt h at the d riv ersho uld e nt er.
On the dr i v ingro ute ofthe  vehicl e a ndaro und  t he vehicl e, there  a re  p ed est rians ,  bicycle s,  ot he r v ehicl e s, obs tacle s, a nd  t h e l ike. Wh i le t he d ri ve r fi nds  t he ro uteo n t he basi s of theind i cati on  b y the c ar navigation  s ystem, mak es  de termin a t ion, and  further performs an op e ration,  th e dri verhas to pa y n ecessa rya ttenti on tothese  o bje c t s out s i de  of  t he vehicle , and  driv ethevehicle  avoiding these ob j ect s.
Accordingl y,ther e is  an ee d  fo ra  vi s u al guidance sys tem for ave h ic le such as anau tomobil e thatreduc e s a bur den impos ed on the  d rive r .  G- protein co upled re ceptors ( G PCRs) ar e pro tei ns res po nsi ble f or tra n sdu cinga sign al  withi n a c el l. GPCRs  have usually seven tra nsmemb ranedom ains. Upo n b i ndi ng of a l igan d to an ex tra -ce llula r p o rtion  orf ra gme n t ofa GP C R, a sign a list r an sduced with i n the  cell  th a t resu ltsin a change in ab iological or p hysi o l ogi cal prop er ty or behaviou r o ft h e cell.GP CRs, alongwith G-p ro t einsand ef fector s (intr a c el l ular e nzym esand chann els  m o dulated  b yG -prote ins) ,are th e comp o nent s of a modular sig nalin g syste m  th at co nn ects th e  sta te of intr a-cellularsecond  mes senge rs to e xt ra-cel lul ar  inputs.
G P CR genesand g ene pro du ctscan  modul atev a rious  phy si olo gical pro c e ss e san d  ar e po tenti al  cau sative ag e nts of d ise a se. The  G PCR s seem t o  b e of critica l i mport a n ce to both thec en t ral n ervous  syste m and p e rip he ral phy sio l o gical pro cesses.
T h e G PC R pr otein su pe rfam il y i srepresented infive
 Application_Publication (JP-A)_No. 2004-117294, a mark_corresponding to_a_route is_presented_in a three-dimensional_display in the_air over a road_corresponding to the_route.
In_JP-A No. 9-34352, a graphic for guidance is changed in accordance with a distance_between_the vehicle_and_a_guiding point.
However, even if various_kinds of car navigation systems_such as_described above are used, a burden imposed on_the_driver is heavy.
For_example, in a typical car navigation system, a guidance_route is not presented in association_with an actual_road_that_is seen from the_driver's seat, and is presented separately_from the actual road. In this_case, the driver has to recognize a_course on the basis of a_route represented by a route_indication, associate_the recognized course and a_real road, identify_the road_that the driver_has to enter from among real_roads on the_basis of the correspondence therebetween, and_perform_a driving operation._It_takes_some time_from when the_route_is presented_to_when the driver performs a driving_operation_by identifying the road that the driver_should enter.
On the driving_route_of the vehicle and_around the vehicle, there are_pedestrians, bicycles, other vehicles, obstacles, and_the like._While the_driver finds the route on the basis of the indication by_the car navigation system, makes determination,_and further performs an_operation, the_driver_has to pay_necessary_attention to_these objects outside of the vehicle, and_drive the_vehicle avoiding these objects.
Accordingly, there is_a need for a_visual_guidance system for a vehicle such_as an automobile that reduces a_burden imposed on the driver._G-protein_coupled_receptors (GPCRs) are proteins responsible_for transducing a signal within a_cell. GPCRs have_usually seven transmembrane domains. Upon binding of_a_ligand to an extra-cellular portion or_fragment_of a GPCR, a signal is_transduced_within_the cell that results in_a change in a biological or_physiological property or behaviour of the cell. GPCRs, along_with G-proteins and_effectors (intracellular enzymes and channels_modulated_by_G-proteins), are the components of a modular signaling system that_connects the_state of intra-cellular_second messengers to extra-cellular inputs.
GPCR genes and gene products can_modulate various physiological processes and are potential_causative agents of disease. The GPCRs seem to be of critical_importance to both the central nervous system and_peripheral physiological processes.
The GPCR protein superfamily is_represented in five