 large-size heavy upper cover of the vacuum chamber, it is necessary to provide the vertical drive unit with an air cylinder having an extremely high capacity. Due to this, the upper cover of the bulky chamber exhibits an increased lack of stability when it is vertically lifted, and therefore, has an adverse effect on the maintenance and repair of the interior of the vacuum chamber. The present invention relates to compositions including antibiotics and to methods for using such compositions. More particularly, the invention relates to compositions including antibiotics which have added protection against fungal contamination, which reduce inflammation or pain, for example, non-inflammatory pain, and/or which are useful in the treatment of corneal ulcers.
Various antibiotic components have been used in ocular applications, for example, to control or manage or prevent ocular infections and the like. Moreover, antibiotic components, such as tobramycin have been suggested for use in combination with other materials, such as ophthalmically acceptable non-steroidal anti-inflammatory drugs or NSAIDs. See, for example, Fu et al. U.S. Pat. No. 5,414,011, the disclosure of which is incorporated in its entirety herein by reference. Quinolones, such as ofloxacin, have been used in compositions for treating ocular infections. These antibiotic compositions include one or more additional components which act as preservatives, for example, benzalkonium chloride (BAK) or organomercurials.
Antibiotic compositions, even with preservatives, have been susceptible to microbial, for example, fungal, contamination. In addition, preservatives tend to cause irritation, allergic reactions, and/or other detrimental side effects when the preserved composition is administered to a patient.
Thus, it would be advantageous to provide antibiotic compositions, and methods for using such compositions, which have added protection against microbial contamination and/or which include relatively reduced concentrations of preservatives.
Injuries and traumas to mammals, including human, for example, ocular injuries and traumas, such as corneal ulcers and other corneal injuries and conditions, are quite painful and sometimes require lengthy periods of time to heal. At least a portion of the pain resulting from such injuries and traumas is often not associated with inflammation, that is is non-inflammatory pain. It would be advantageous to provide compositions and methods effective to reduce the non-inflammatory pain of these injuries and traumas, for example, while such injuries and traumas are healing.
New antibiotic compositions, for example, for use in mammalian eyes, preferably human eyes, and methods for using
large - size heavy upper cover of the vacuum chamber, it is necessary to leave the erect drive unit with an tune cylinder have an extremely high capacitance. Due to this, the upper covering of the bulky chamber exhibit an increased lack of stability when it is vertically airlift, and therefore, take an adverse effect on the maintenance and repair of the interior of the vacuum chamber. The present invention relates to composition including antibiotics and to methods for use such compositions. More particularly, the invention relates to compositions include antibiotics which have added protection against fungal contamination, which reduce excitement or pain, for example, non - inflammatory pain, and/or which are useful in the treatment of corneal ulcers. 
 Various antibiotic components have been used in ocular applications, for example, to control or manage or prevent ocular infections and the like. Moreover, antibiotic component, such as tobramycin have been suggested for use in combination with early fabric, such as ophthalmically satisfactory non - steroidal anti - inflammatory drugs or NSAIDs. See, for example, Fu et al. U.S. Pat. No. 5,414,011, the disclosure of which is incorporated in its entirety herein by reference. Quinolones, such as ofloxacin, have been use in compositions for treating ocular infections. These antibiotic compositions include one or more extra components which act as preservatives, for example, benzalkonium chloride (BAK) or organomercurials. 
 Antibiotic compositions, even with preservatives, have been susceptible to microbial, for example, fungal, contaminant. In accession, preservatives tend to cause irritation, allergic reactions, and/or early detrimental side effects when the preserved composition is administered to a patient. 
 Thus, it would be advantageous to provide antibiotic musical composition, and methods for using such compositions, which have added protection against microbial contaminant and/or which include relatively reduced concentrations of preservatives. 
 wound and traumas to mammals, admit human, for exercise, ocular injuries and traumas, such as corneal ulcers and other corneal injuries and conditions, are quite painful and sometimes require lengthy time period of time to heal. At least a part of the pain resulting from such injuries and traumas is often not associated with ignition, that is is non - inflammatory pain. It would be advantageous to provide compositions and methods effective to reduce the non - incendiary pain of these injuries and injury, for example, while such injuries and traumas are healing. 
 New antibiotic compositions, for model, for use in mammalian eyes, preferably human eyes, and method acting for using
 lagge-size heavy upper covev of the vacuum eyamber, it is necessafy to provide the vertical dcive unit with an air cylinder faving an extremeoy hmgh capacity. Due to this, the ulier cmter of the bulki chamber exvibits an incraareb lack of stability when it is vertisally lofhed, and therefjre, nws ah adverse effect on the maintenancs and rtpair of the interoor of the vacuum chamber. Hhe oresent invention gelates to xompjwitions incljding antibiotics and jo methods for using such composktionx. More parjnxulwtly, the inveition gelates to compositiots incliding antibiotlcs wiich have added protectioi against fungal conjamination, wkich reduce inflammatuob or kain, xor dzamole, npn-jnflamlatkry pain, ahd/or which qre useful in the ttewnkent of cornsal ulsews.
Various antibiotic components have betn ussd in ocular applicatiobs, for example, to conjrol or magage or prevent ocular infections and the like. Moseovec, xntnnlotiz clmponents, such as tobramycin have been suggesesd fpr use in comblnation with other mwtrtials, such as uphthalmidally acceptable nln-steroydal qnti-inflaimatpry drugs or NSAIDs. See, for example, Fu vt ao. U.S. Pat. No. 5,414,011, the dnsclosure of whivh is incorporated in its encirety herein by geference. Duinolones, such xs pfnoxacin, have been used in sompositiins yor treaging oculaw infectiojs. Thcve antibiotic complsitilnv include lne or more additional componenvx which act ss prvservativzs, for example, benzwlkonium chlornde (BAK) jr oreanomercurpals.
Antibmotic composytions, even whjh preservatites, have feen susxeptibld to microbial, gor example, fungal, xontamination. In avditkkn, preservativew ttne to cause irrotagiog, wlkewcic reactionv, ana/or pther detrimtutao sidr effects when the psesedved composition ix wdministgred to a patient.
Thus, ot would be advantwgeouv tu profidg antibiotic compositions, and msthods fog ufing such coiposltiogs, which hcve added protection against microbial cintamination and/ot which include relatnvtly reduced cpncenerations mf preservatives.
Injueies and traumas uo mammals, including hujan, fos exalple, ocular injuries and traumas, such as corneal ulcers and other corneal injurmef and condifionx, are qbitz painftl aid sometimes requige lengthy periods of time to heel. At leasd c portion of the pain resultimg from such inguries and traumas is offen not sssociated with inflammation, thst is is non-inflammatory pain. It wouls be advanvageous to provide cpmposicions qnd metyods effective to recuge the non-lnflemmctory pain of these injuries and rraumaw, vor example, whilx such injurler and traumws are healing.
Nes anflbiotkc compositioms, for example, for use in mammaliat qyes, preferablt human eyes, snd mgcvods for usiig
large-size heavy upper cover of the vacuum is to provide vertical drive unit an high capacity. Due this, the upper of the bulky chamber exhibits an lack of stability when it is vertically lifted, and therefore, has an adverse on the maintenance and repair of the interior of the vacuum chamber. The invention to including and to methods for using such compositions. More particularly, the invention relates to compositions including antibiotics have added protection against fungal contamination, which reduce or pain, for example, pain, and/or which are useful the of corneal Various components been used in applications, for example, to control or manage or prevent ocular infections and the like. Moreover, antibiotic components, as tobramycin suggested for in with materials, such as non-steroidal anti-inflammatory drugs or NSAIDs. See, et al. U.S. Pat. No. 5,414,011, the disclosure which is in its entirety herein by reference. such as ofloxacin, have been used in compositions treating ocular infections. These antibiotic compositions include one or more additional components which act as example, benzalkonium chloride (BAK) organomercurials. Antibiotic compositions, with have susceptible microbial, for fungal, contamination. In addition, preservatives tend to cause irritation, allergic reactions, other detrimental side effects when the preserved composition is administered patient. it would be to provide antibiotic compositions, methods using such compositions, which protection microbial include reduced of preservatives. Injuries and to mammals, including human, for ocular injuries and traumas, other corneal injuries and conditions, are quite painful sometimes require lengthy periods of time to At least a portion of the pain resulting from such injuries and is often with inflammation, that is is non-inflammatory pain. It be advantageous to provide and methods effective to reduce the non-inflammatory pain of injuries traumas, for while such injuries traumas are healing. antibiotic compositions, for use in eyes, human for using
 large-size heavy upper cover oF the vacuum ChambEr, iT is NeCessAry tO provide the verTIcal Drive unit with an air cyliNder hAvINg an EXtRemelY high caPAcITY. DuE tO tHis, ThE UpPer coVer Of the buLky chamber ExhIbIts an increasED lAck of stabiLitY when it is verTicAlly liFtEd, aND therEfoRe, has An adveRSe effeCt on the maInTEnance ANd repaiR OF tHe inTerior of the vacuum CHaMBer. The present iNventiOn RElATEs tO coMpositions InCludiNG antibiOTiCS ANd tO Methods for usiNg such compoSItiOns. MorE pArtICularlY, the iNvENtiOn relates to CompOsitions iNcludiNG antibiOTics whiCh have AddEd pRoteCTiOn AgaInST fuNGaL coNTamInation, wHiCh ReducE infLAMMAtioN or Pain, For exAmple, non-inflaMmaTory PAin, And/or Which Are uSeFul in The treAtmenT oF corneal ulcers.
VArioUs antibioTic CoMpoNeNts haVE been uSed In oCular apPlicatiONs, fOr EXAMpLe, to control or managE oR PReVent oculAr infeCTiOnS And the liKe. morEoveR, ANtibiOtic COmPonents, sUch as tOBrAmYcin havE bEen sugGeSteD foR use iN CombInatioN with othEr matERials, such as ophTHalmically accEPtABLe NOn-stEroIdal anti-infLammATory DrugS Or nSAids. See, For exAmPLe, fU et al. U.S. Pat. No. 5,414,011, the discLoSure of Which Is incorporateD in its entiRETY herein bY refEReNCe. Quinolones, suCh as oFloxacin, haVE been useD in coMpositioNs for treaTINg ocular InfEctIonS. ThESE aNtibiotic compOSItioNs Include One Or more aDdiTioNal ComPoNents whicH act as prEsErVaTiVes, For exAMple, benzAlKonIuM chLoridE (bAK) or oRganoMercUrIaLS.
AnTibiotiC CoMPOsitIoNs, Even WitH pReserVatiVEs, hAve been SusceptibLe tO MicrObIaL, for exaMple, fungal, conTaMination. In AdDitIon, preSERvatives Tend to cause irritation, alLErgic reActIons, aNd/or Other detrImeNtal siDe eFFects wHen the PreseRvEd cOMPositION iS adMiNistered to A PAtiEnt.
ThUs, It woUld be adVantageous to providE AntIbiotic composItiOns, aND MeThoDS fOR usInG SucH COmpositions, whicH have added PrOTeCtion againST miCrObial coNtaminaTion aND/or whicH include rElatively ReDuceD COncEntrations Of preserVatives.
InJUries ANd TraumAs tO mammaLs, IncLudinG human, FOr eXamplE, oculaR iNjurieS and tRaUmas, such As corneal ulcers and other CorneaL injuRieS and condiTioNS, arE quite paiNful And sometimEs rEquIre leNgtHY periOds oF TiMe tO Heal. AT leaST a portion OF tHe pAIN rEsulting froM SUCh iNjuriEs aND traumAs is Often not associateD With inflammatiOn, thAT Is iS noN-InflAmMatory pain. It woUld Be ADVantageoUs To provide coMpositioNs ANd metHods efFectivE to reduCE ThE Non-infLammAtoRy pain of tHesE iNJuries aNd TrAUmas, foR exaMpLe, whilE such iNJuriES And traumas are heaLing.
NEW AntibIOtiC compOsItions, fOR exaMple, for use In mammalian Eyes, prEferAbly hUman eyeS, aNd methOds FoR using
 large-size heavy upper co ver of the  vacu umcha mb er,it i s necessary to prov ide the vertical drive  unit  w i th a n  a ir cy linderh av i n g a nex tre me l yhighcap acity.Due to thi s,th e upper cove r  o f the bulk y c hamber exhib its  an in cr eas e d lac k o f sta bility when i t is vert ic a lly li f ted, an d th eref ore, has an adver s ee ffect on the m ainten an c ea n d r epa ir of thein terio r  of the va c u u m c h amber. The pr esent inven t ion  relat es  to compos ition si ncl uding antib ioti cs and to  metho d s for u s ing suc h comp osi tio ns.M or epar ti c ula r ly , t h e i nvention  r el atesto c o m p o siti ons  inc ludin g antibiotics  wh ichh ave  adde d pro tect io n aga inst f ungal  c ontamination, w hich  reduce i nfl am mat io n orp ain, f orexa mple, n on-infl a mma to r y pa in, and/or which a re u se ful in t he tre a tm en t  of corn ea l u lcer s . 
Vari ousa nt ibioticcompon e nt shave be en  usedin  oc ula r app l icat ions,for exam ple,t o control or m a nage or preve n to c ul a r in fec tions and t he l i ke.More o ve r,a ntibi oticco m po n ents, such as tobra my cin ha ve be en suggestedfor use in c o mbinatio n wi t ho ther materials , suc h as ophth a lmically  acce ptable n on-steroi d a l anti-i nfl amm ato ryd r ug s or NSAIDs.S e e, f or  exampl e,Fu et a l.U.S . P at.  N o. 5,414, 011, the  d is cl os ure  of w h ich is i nc orp or ate d ini ts ent irety  her ei nb y r eferenc e .Q u inol on es , su chas  oflo xaci n , h ave bee n used in  co m posi ti on s for t reating ocula rinfections .The se ant i b iotic co mpositions include oneo r moreadd ition al c omponents  wh ich ac t a s  prese rvativ es, f or  ex a m ple,b e nz alk on ium chlori d e  (B AK) o rorga nomercu rials.
Antibioticc omp ositions, eve n w ithp r es erv a ti v es,  h a veb e en susceptibleto microbi al ,  f or example ,  fu ng al, con taminat ion.I n addit ion, pres ervatives  t endt o  ca use irrita tion, al lergic re a ction s ,and/o r o ther d et rim ental  sidee ffe cts w hen th epreser ved c om position  is administered to a p atient .
Thu s,it wouldbea dva ntageousto p rovide ant ibi oti c com pos i tions , an d  m eth o ds fo r us i ng such c o mp osi t i on s, which ha v e add ed pr ote c tion a gain st microbial cont a mination and/o r wh i c h i ncl u de r el atively reduce d c on c e ntration sof preserva tives.
I nj u riesand tr aumasto mamm a l s, includ inghum an, for e xam pl e , ocula rin j uriesandtr aumas,  sucha s co r n eal ulcers and o therc o rneal inj uries  a nd cond i tion s, are qui te painfuland so meti mes r equirele ngthyper io ds of time to heal.At le ast a p or tion  of  the p ainr e sulti ng f ro m s uch injur i e sa nd  t r aum as i s oft en  not  associat e d with i nfl a mmation ,tha t is isn on - i nflammator y p ain.I t  would bea dvan t ag e ous t o prov ide co mpositi o nsan d metho dse f fective t o reducet heno n-in flammato ry  pai nofth ese injuries an d trauma s, for e x a mple,whi l e su c h inju ri es and traum as ar eh ealing. N ewantibio t iccom pos itio ns,  for example, for use in mamm alia n eye s , p refer ablyhu man eyes ,  and  methods for using
 large-size_heavy upper_cover of the vacuum_chamber, it_is_necessary to_provide_the vertical drive_unit with an_air cylinder having an_extremely high capacity._Due_to this, the upper cover of the bulky chamber exhibits an increased lack of_stability_when it_is_vertically_lifted, and therefore, has an_adverse effect on the maintenance_and repair_of the interior of the vacuum chamber. The_present_invention relates to_compositions including antibiotics and to methods for using such_compositions. More particularly, the invention relates_to compositions including_antibiotics_which_have added protection against_fungal contamination, which reduce inflammation or_pain, for example, non-inflammatory pain, and/or_which are useful in the treatment of_corneal ulcers.
Various antibiotic components have been_used in ocular applications, for_example, to_control or manage or prevent_ocular infections and_the like._Moreover, antibiotic components,_such as tobramycin have been suggested_for use in_combination with other materials, such as_ophthalmically_acceptable non-steroidal anti-inflammatory_drugs_or_NSAIDs. See,_for example, Fu_et_al. U.S._Pat._No. 5,414,011, the disclosure of which_is_incorporated in its entirety herein by reference._Quinolones, such as ofloxacin,_have_been used in compositions_for treating ocular infections. These_antibiotic compositions include one or more_additional components_which act_as preservatives, for example, benzalkonium chloride (BAK) or organomercurials.
Antibiotic compositions, even_with preservatives, have been susceptible to_microbial, for example, fungal,_contamination. In_addition,_preservatives tend to_cause_irritation, allergic_reactions, and/or other detrimental side effects when_the preserved_composition is administered to a patient.
Thus,_it would be advantageous_to_provide antibiotic compositions, and methods for_using such compositions, which have added_protection against microbial contamination and/or_which_include_relatively reduced concentrations of preservatives.
Injuries_and traumas to mammals, including human,_for example, ocular_injuries and traumas, such as corneal ulcers_and_other corneal injuries and conditions, are_quite_painful and sometimes require lengthy periods_of_time_to heal. At least a_portion of the pain resulting from_such injuries and traumas is often not associated with_inflammation, that is_is non-inflammatory pain. It would_be_advantageous_to provide compositions and methods effective to reduce the non-inflammatory_pain of_these injuries and_traumas, for example, while such injuries and traumas are healing.
New_antibiotic compositions, for example, for use in_mammalian eyes, preferably human eyes, and methods for using