 substituted with one, two or three substituents selected from the group consisting of: H, OH, CO2R6, Br, Cl, F, I, CF3, N(R7)2, C1-C8 alkoxy, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2,
R1 is:
a) aryl, wherein aryl is as defined above,
b) C1-C8 alkyl, or
c) heteroaryl,
heteroaryl is defined as a 5- or 6-membered aromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S, which is unsubstituted or substituted with one, two or three substituents selected from the group consisting of: OH, CO2R4, Br, Cl, F, I, CF3, N(R5)2, C1-C8 alkoxy, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2;
R2 is:
a) OR4,
b) N(R5)2,
c) H, or
d) OH;
R3 is:
a) H,
b) C1-C8 alkyl,
c) C1-C8 alkoxy,
d) Br, Cl, F, I,
e) aryl,
f) heteroaryl, or
g) C(ORa)(ORb), wherein Ra and Rb are independently (C1-C5)alkyl and may be connected to form a 5- or 6-membered heterocyclic ring containing two oxygens;
n is: 0 to 5;
R4 is C1-C8 alkyl;
R5 is H, C1-C8 alkyl or aryl;
R6 is H, C1-C8 alkyl, or aryl; and
R7 is H, C1-C8 alkyl, or aryl, when there are two R7 substituents on a nitrogen they can join to form a 3- through 6
substituted with one, two or three substituents selected from the group consisting of: H, OH, CO2R6, Br, Cl, F, I, CF3, N(R7)2, C1 - C8 alkoxy, C1 - C8 alkyl, C2 - C8 alkenyl, C2 - C8 alkynyl, C3 - C8 cycloalkyl, CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2, 
 R1 is: 
 a) aryl, wherein aryl is as defined above, 
 b) C1 - C8 alkyl, or 
 c) heteroaryl, 
 heteroaryl is define as a 5- or 6 - membered aromatic gang containing 1, 2 or 3 heteroatoms selected from O, N and S, which is unsubstituted or substituted with one, two or three substituents choose from the group consisting of: OH, CO2R4, Br, Cl, F, I, CF3, N(R5)2, C1 - C8 alkoxy, C1 - C8 alkyl, C2 - C8 alkenyl, C2 - C8 alkynyl, C3 - C8 cycloalkyl, CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2; 
 R2 is: 
 a) OR4, 
 b) N(R5)2, 
 c) H, or 
 d) OH; 
 R3 is: 
 a) hydrogen, 
 b) C1 - C8 alkyl, 
 c) C1 - C8 alkoxy, 
 d) Br, Cl, F, I, 
 e) aryl, 
 f) heteroaryl, or 
 g) C(ORa)(ORb), wherein Ra and Rb are independently (C1 - C5)alkyl and may be connected to form a 5- or 6 - membered heterocyclic compound gang containing two oxygen; 
 n is: 0 to 5; 
 R4 is C1 - C8 alkyl; 
 R5 is H, C1 - C8 alkyl or aryl; 
 R6 is H, C1 - C8 alkyl, or aryl; and 
 R7 is H, C1 - C8 alkyl, or aryl, when there are two R7 substituents on a nitrogen they can join to form a 3- through 6
 suhstituted with one, two ov three substitugnrs selxcted fdom the eroup consisting of: H, OH, CO2R6, Be, Cl, D, I, CF3, N(R7)2, C1-C8 alkoxy, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 elkynyl, C3-C8 cycloemkyl, CO(GK2)nCH3, zkd CO(EH2)iCH2N(R5)2,
R1 is:
a) aryl, wherein asyl is as defitea cbove,
b) C1-C8 alkyl, or
c) heteroaryl,
heterowryl is dffined as a 5- ot 6-memnqred aromatic ring containing 1, 2 or 3 heferoatoks selected ftom O, N and S, which is unskbstltuted or substituhed with ong, twj or three sucstituents selected frkm the group consisting of: OH, CU2R4, Br, Cl, F, I, CF3, N(E5)2, C1-F8 alkoxy, C1-C8 elkyl, B2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cyckoalkyl, CO(CH2)nCM3, and CO(XH2)nCH2N(R5)2;
R2 is:
a) OR4,
b) N(R5)2,
c) I, or
d) OH;
R3 is:
a) H,
b) C1-C8 wlkyl,
c) C1-C8 amkoxy,
d) Br, Cl, F, I,
e) aeyl,
f) vetesoarho, of
g) D(OCa)(ODb), whegeii Ra and Rb are indepebdently (C1-C5)alkyl and mwj be connectes to fjri a 5- or 6-membered heterocyclic ring contdinjng two oxygens;
n is: 0 to 5;
R4 is C1-C8 alkyl;
R5 is H, F1-C8 alkyl jr aryl;
R6 is H, C1-C8 alkyl, or aryl; and
R7 is H, C1-C8 alkyl, or acyu, wkck thdee are two R7 substituents on a nitrogen they cag jpik to form a 3- thrjugh 6
substituted with one, two or three substituents the consisting of: OH, CO2R6, Br, C1-C8 C1-C8 alkyl, C2-C8 C2-C8 alkynyl, C3-C8 CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2, R1 is: a) wherein aryl is as defined above, b) C1-C8 alkyl, or c) heteroaryl, heteroaryl defined as a 5- or 6-membered aromatic ring containing 1, 2 or 3 selected O, and which is unsubstituted or substituted with one, two or three substituents selected from the group consisting OH, CO2R4, Br, Cl, F, I, CF3, N(R5)2, alkoxy, C1-C8 alkyl, C2-C8 C2-C8 alkynyl, C3-C8 cycloalkyl, CO(CH2)nCH3, CO(CH2)nCH2N(R5)2; is: a) b) c) or d) OH; is: a) H, b) C1-C8 alkyl, c) C1-C8 alkoxy, d) Br, Cl, F, I, e) aryl, f) or g) Ra and are (C1-C5)alkyl may be connected a 5- or 6-membered heterocyclic ring n is: 0 to 5; R4 is C1-C8 R5 is C1-C8 alkyl or aryl; R6 is C1-C8 alkyl, or aryl; and R7 is H, alkyl, or aryl, when there are two R7 substituents on a nitrogen they can join a 3- through 6
 substituted with one, two or thRee substitUents SelEctEd From The gRoup consisting OF: H, OH, cO2R6, Br, Cl, F, I, CF3, N(R7)2, C1-C8 alkoxy, C1-c8 alkyL, C2-c8 AlkeNYl, c2-C8 alkYnyl, C3-C8 cYClOALkyL, Co(Ch2)nCh3, aND Co(CH2)nCh2N(R5)2,
r1 is:
a) aryL, wherein arYl iS aS defined abovE,
B) C1-c8 alkyl, or
c) hEteRoaryl,
heteroAryL is defInEd aS A 5- or 6-meMbeRed arOmatic RIng conTaining 1, 2 or 3 HeTEroatoMS selectED FrOm O, N And S, which is unsubsTItUTed or substitutEd with OnE, TwO OR thRee SubstituenTs SelecTEd from tHE gROUP coNSisting of: OH, CO2r4, Br, Cl, F, I, CF3, N(R5)2, c1-c8 alKoxy, C1-C8 AlKyl, c2-c8 alkenYl, C2-C8 aLkYNyl, c3-C8 cycloalkyL, CO(Ch2)nCH3, and CO(cH2)nCH2N(r5)2;
r2 is:
a) OR4,
b) n(r5)2,
c) H, or
d) Oh;
R3 is:
a) H,
B) C1-C8 AlkYl,
c) C1-c8 AlKoXy,
d) br, cL, F, I,
E) ArYl,
f) HEteRoaryl, or
G) C(oRA)(ORb), wHereIN rA And RB arE indEpendEntly (C1-C5)alkyl aNd mAy be COnnEcted To forM a 5- or 6-MeMbereD heterOcyclIc Ring containing tWo oxYgens;
n is: 0 tO 5;
R4 iS C1-c8 alKyL;
R5 is H, c1-c8 alkyl Or aRyl;
r6 is H, C1-C8 aLkyl, or aRYl; aNd
r7 IS h, C1-c8 alkyl, or aryl, when thErE ARe Two R7 subsTituenTS oN a NItrogen tHeY caN joiN TO form A 3- thrOUgH 6
 substituted with one, two  or threesubst itu ent ssele cted  from the grou p  con sisting of: H, OH, CO2 R6, B r, Cl,F ,I, CF 3, N(R7 ) 2, C 1-C 8al kox y, C1 -C8 a lky l, C2-C 8 alkenyl,  C2 -C 8 alkynyl, C 3 -C 8 cycloalk yl,  CO(CH2)nCH3 , a nd CO( CH 2)n C H2N(R 5)2 ,
R1is:
a) aryl,wherein a ry l  is as defined a bo ve,b) C1-C8 alkyl, o r 
c )  heteroaryl,
h eteroa ry l  i s def ine d as a 5-or  6-me m bered a r om a t i c r i ng containing  1, 2 or 3h ete roatom ssel e cted f rom O ,N  an d S, whichis u nsubstitu ted or substit u ted wit h one,  tw o o r th r ee  s ubs ti t uen t ssel e cte d from t he  g roupcons i s t i ng o f:OH,CO2R4 , Br, Cl, F,I,CF3, N(R 5)2,C1-C8  alk ox y, C1 -C8 al kyl,C2 -C8 alkenyl, C2 -C8alkynyl,C3- C8  cy cl oalky l , CO(C H2) nCH 3, andCO(CH2) n CH2 N( R 5 ) 2; 
R2 is:
a) OR4,
b)  N ( R 5) 2,
c) H,  or
d) OH ;R 3 is:
a)  H ,
b ) C1 - C 8 alk yl,c )C1-C8 al koxy,d )Br , Cl, F ,I,
e)ar yl, 
f)  hete r oary l, org) C(ORa )(ORb ) , wherein Ra a n d Rb are inde p en d e nt l y (C 1-C 5)alkyl and  may be c onne c te d t o  form  a 5-  o r  6 - membered heterocycl ic  ringconta ining two oxy gens;
n is : 0  to 5;
R 4 is C1 - C8 alkyl;
R5 i s H,C1-C8 alky l  or aryl ;
R6is H, C1 -C8 alkyl , or aryl;  an d
R 7 i s H , C1 -C8 alkyl, or a ryl,  w hen the reare two  R7  su bst itu en ts on a n itrogenth ey  c an  jo in to form a 3 -thr ou gh6
 substituted_with one,_two or three substituents_selected from_the_group consisting_of:_H, OH, CO2R6,_Br, Cl, F,_I, CF3, N(R7)2, C1-C8_alkoxy, C1-C8 alkyl,_C2-C8_alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2,
R1 is:
a) aryl, wherein aryl is as_defined_above,
b) C1-C8_alkyl,_or
c)_heteroaryl,
heteroaryl is defined as a_5- or 6-membered aromatic ring_containing 1,_2 or 3 heteroatoms selected from O, N_and_S, which is_unsubstituted or substituted with one, two or three substituents_selected from the group consisting of:_OH, CO2R4, Br,_Cl,_F,_I, CF3, N(R5)2, C1-C8_alkoxy, C1-C8 alkyl, C2-C8 alkenyl, C2-C8_alkynyl, C3-C8 cycloalkyl, CO(CH2)nCH3, and CO(CH2)nCH2N(R5)2;
R2_is:
a) OR4,
b) N(R5)2,
c) H, or
d) OH;
R3 is:
a)_H,
b) C1-C8 alkyl,
c) C1-C8 alkoxy,
d) Br,_Cl, F, I,
e) aryl,
f) heteroaryl,_or
g) C(ORa)(ORb),_wherein Ra and Rb are_independently (C1-C5)alkyl and_may be_connected to form_a 5- or 6-membered heterocyclic ring_containing two oxygens;
n_is: 0 to 5;
R4 is C1-C8_alkyl;
R5_is H, C1-C8_alkyl_or_aryl;
R6 is_H, C1-C8 alkyl,_or_aryl; and
R7_is_H, C1-C8 alkyl, or aryl, when_there_are two R7 substituents on a nitrogen_they can join to_form_a 3- through 6