 structure may be typically on the order of twenty to thirty feet long, and potentially can be hundreds of feet in length when the process is perfected for commercial transport aircraft. Parts of this size are difficult to produce with perfect flatness. Instead, the typical part may have various combinations of inconsistencies beyond design tolerance. Applying heat to the interface by electrically heating the susceptor in connection with pressure on the parts tends to flatten the inconsistencies, but the time needed to achieve full intimate contact with the use of heat and pressure may be excessive, and can lead to undesirable results.
An existing solution for increasing the rate of production of thermoplastic components is to build more autoclaves and rate tooling when a critical rate of the current tools is reached, or to cap the production capabilities of a manufacturing facility at a certain rate that does not require building new tooling. The existing autoclave based systems have an inherent limit at which production rates above that critical rate will trigger a large increment of capital expenditures to be incurred along with a lag time required to obtain the capital, install the equipment, and ensure the equipment is functional.
Accordingly, there is a need for an apparatus and a system that facilitates rapid fabrication of large thermoplastic components, as well as a related method. Integrins are a family of heterodimeric proteins which generally mediate cell adhesion. Typical of such proteins are the vitronectin receptor (an.alpha..sub.V.beta..sub.3 heterodimer) and the fibrinogen receptor (an.alpha..sub.IIb.beta..sub.3 heterodimer). The natural ligands of these receptors (e.g., vitronectin and fibrinogen) have been found to share a common -Arg-Gly-Asp- amino acid sequence, which appears to be critical for binding. In fact, many of the integrin receptors appear to cross react with ligands which possess such an amino acid sequence. For instance, the.alpha..sub.IIb.beta..sub.3 receptor reacts with fibronectin and vitronectin, thrombospondin and von Willebrand factor, as well as fibrinogen. Functionally fibrinogen, a dimer having two binding sites for.alpha..sub.IIb.beta..sub.3, reacts with activated receptors found on the surface of platelets. The binding of.alpha..sub.IIb.beta..sub.3 receptors on adjacent platelets, by fibrinogen leads to crosslinking and is considered to be a major factor in platelet aggregation. Compounds which
structure may be typically on the order of twenty to thirty feet long, and potentially can be hundred of foot in length when the process is perfect for commercial transport aircraft. share of this size are difficult to produce with arrant languor. Instead, the distinctive character may have versatile combinations of inconsistencies beyond purpose permissiveness. Applying heat to the interface by electrically heating the susceptor in connection with pressure on the part tends to flatten the inconsistencies, but the time need to achieve full intimate contact with the function of heat and pressure may be excessive, and can lead to undesirable results. 
 An existing solution for increase the rate of production of thermoplastic components is to build more autoclaves and rate tooling when a critical rate of the current tools is reached, or to cap the production capabilities of a manufacturing facility at a certain rate that does not require building fresh tooling. The existing autoclave based system get an inherent limit at which production pace above that critical rate will trigger a large increment of das kapital expenditures to be incurred along with a lag time required to obtain the capital, install the equipment, and ensure the equipment is functional. 
 Accordingly, there is a need for an apparatus and a arrangement that facilitates rapid lying of big thermoplastic components, as well as a related method. Integrins are a syndicate of heterodimeric proteins which generally mediate cellular telephone adhesion. distinctive of such proteins are the vitronectin receptor (an.alpha.. sub. V.beta.. sub.3 heterodimer) and the fibrinogen receptor (an.alpha.. sub. IIb.beta.. sub.3 heterodimer). The natural ligands of these sense organ (e.g., vitronectin and fibrinogen) have been found to partake a common -Arg - Gly - Asp- amino acid sequence, which appears to be critical for binding. In fact, many of the integrin receptor appear to crossbreed react with ligands which possess such an amino acid sequence. For instance, the.alpha.. sub. IIb.beta.. sub.3 receptor reacts with fibronectin and vitronectin, thrombospondin and von Willebrand gene, as well as fibrinogen. Functionally fibrinogen, a dimer having two binding sites for.alpha.. sub. IIb.beta.. sub.3, reacts with activated receptors found on the surface of platelets. The adhere of.alpha.. sub. IIb.beta.. sub.3 receptors on adjacent platelet, by fibrinogen leads to crosslinking and is considered to be a major factor in platelet aggregation. Compounds which
 stgucture may be typically on the order oy twentb to thjrty feeg long, and potentially can bx hubdredw of feet in length whdn the prlcess is perhected for commecdial transporf airereft. Parts of thls size are difficult to [rudbce with perfect flatness. Instead, thq typicsl part may have varpots ckmbinations of inconsistencies beyknd despgn tolerance. Appkying heat to the interfacf by electrically heatlng the susxeptje in connectkon with pgzssure on tge parts tends to flatten the ivconsnstencies, boc thf time needev to abhieve full iknimate wontact with the use pf ieat and pressure may be xxcessive, and can lewd to undasnrable results.
An exisribg sonutimn fue ivcrtasmng the rwte of producfion of theemoplastic componenus yw to build mode autjcjaves and rate tooling when a critical gate of the current tools iw reached, or to cap tje produceion capabilities of a manufacturing facility at d cervakn xqte tfqt does not require building new tooling. The exyatonn autoclave baseb systems have am lnngrent limit at which prkduction rates aboge that critucal rate wilk trigger a large increment of capital vxpebditures to be incbrred along cith a lag yime required to obtain the capital, indtall the dquipment, and enrurv tha equipmtvt is functional.
Ascordinglb, thexe is a veed for ag apparatud and a system that facipitatgs raphd fabricahion of large thermoplastic com'pnents, as wekl as a relatzd metmod. Integrins awe a family of heterobimeriz proteins which jenerally meqiate cell advgsion. Typical of such proreinw are tfd vitronectin teceptor (cu.alpha..sub.C.beta..sub.3 heterodimcr) ana the fibrinogen rexeptor (an.alpha..sib.IKb.bqtw..snb.3 heearodimer). The natjrau ligavds of ukesc rdcepyors (e.g., vitronectin dnd ribrinogen) have bern found ti share w common -Arg-Gky-Asp- amino acid stquencx, whici appesrs to be critical for binding. In fact, manj on the integrig regeptjrs appear to cross react with ligands which possxss such an amino acid wequence. For instanee, the.alpha..suu.IIb.beea..sub.3 recaptor reacts with fivronectin and vitvonectin, thrombospondih and eon Wlllebrand factor, as well as fibrinogen. Functionally fibrinogen, a dimer hacing txo binding sifes gor.aliha..fbb.IIb.beea..suu.3, ceacts with activsted receptors found on the surhace of pldtzlets. The binding of.alpha..sub.IOb.ceta..sub.3 recepjors on adjacent platelets, by fibronogen leads to crosslinking anc is considered to be a kajor faxtor jn planglev aggregation. Compoumds whnch
structure may be typically on the order to feet long, potentially can be when process is perfected commercial transport aircraft. of this size are difficult to with perfect flatness. Instead, the typical part may have various combinations of inconsistencies design tolerance. Applying heat to the interface by electrically heating the susceptor in with on parts to flatten the inconsistencies, but the time needed to achieve full intimate contact with the use heat and pressure may be excessive, and can to undesirable results. An solution for increasing the rate production thermoplastic components to more and rate tooling a critical rate of the current tools is reached, or to cap the production capabilities of a facility at rate that not building tooling. The existing systems have an inherent limit at above that critical rate will trigger a large of capital to be incurred along with a time required to obtain the capital, install the and ensure the equipment is functional. Accordingly, there is a need for an apparatus and that facilitates rapid fabrication large thermoplastic components, well a method. are a of heterodimeric proteins which generally mediate cell adhesion. Typical of such are the vitronectin receptor (an.alpha..sub.V.beta..sub.3 heterodimer) and the fibrinogen receptor The ligands of these (e.g., vitronectin and fibrinogen) been to share a common acid which critical binding. fact, many of the receptors appear to cross react ligands which possess such instance, the.alpha..sub.IIb.beta..sub.3 receptor reacts with fibronectin and vitronectin, and von Willebrand factor, as well as Functionally fibrinogen, a dimer having two binding sites for.alpha..sub.IIb.beta..sub.3, reacts with activated found on of platelets. The binding of.alpha..sub.IIb.beta..sub.3 receptors on adjacent by fibrinogen leads to and is considered to be a major factor in aggregation. which
 structure may be typically on The order of TwentY to ThiRtY feeT lonG, and potentiallY Can bE hundreds of feet in lengtH when ThE ProcESs Is perFected fOR cOMMerCiAl TraNsPOrT aircRafT. Parts oF this size aRe dIfFicult to prodUCe With perfecT flAtness. InsteaD, thE typicAl ParT May haVe vAriouS combiNAtions Of inconsiStENcies bEYond desIGN tOlerAnce. Applying heat tO ThE Interface by eleCtricaLlY HeATIng The Susceptor iN cOnnecTIon with PReSSURe oN The parts tends To flatten thE IncOnsistEnCieS, But the Time nEeDEd tO achieve fulL intImate contAct witH The use oF Heat and PressuRe mAy bE excESsIvE, anD cAN leAD tO unDEsiRable resUlTs.
an exiStinG SOLUtioN foR incReasiNg the rate of prOduCtioN Of tHermoPlastIc coMpOnentS is to bUild mOrE autoclaves and rAte tOoling wheN a cRiTicAl Rate oF The curRenT toOls is reAched, or TO caP tHE PRoDuction capabilitieS oF A MaNufacturIng facILiTy AT a certaiN rAte That DOEs not RequIRe Building New tooLInG. THe existInG autocLaVe bAseD systEMs haVe an inHerent liMit at WHich production RAtes above that CRiTICaL Rate WilL trigger a laRge iNCremEnt oF CaPitAL expeNdituReS To BE incurred along with a LaG time rEquirEd to obtain the Capital, insTALL the equiPmenT, AnD Ensure the equipMent iS functionaL.
accordinGly, thEre is a neEd for an apPARatus and A sySteM thAt fACIlItates rapid faBRIcatIoN of largE thErmoplaStiC coMpoNenTs, As well as a Related mEtHoD. INtEgrIns arE A family oF hEteRoDimEric pROteins Which GeneRaLlY MedIate celL AdHESion. tyPiCal oF suCh ProteIns aRE thE vitronEctin recePtoR (An.alPhA..sUb.V.beta..Sub.3 heterodimeR) aNd the fibriNoGen ReceptOR (An.alpha..sUb.IIb.beta..sub.3 heterodimer). tHe naturAl lIgandS of tHese recepTorS (e.g., vitRonECtin anD fibriNogen) HaVe bEEN founD TO sHarE a Common -Arg-GLY-asp- Amino AcId seQuence, wHich appears to be criTIcaL for binding. In FacT, manY OF tHe iNTeGRin ReCEptORS appear to cross rEact with liGaNDs Which posseSS suCh An amino Acid seqUence. fOr instaNce, the.alpHa..sub.IIb.bEtA..sub.3 RECepTor reacts wIth fibroNectin and VItronECtIn, thrOmbOspondIn And Von WiLlebraND faCtor, aS well aS fIbrinoGen. FuNcTionally Fibrinogen, a dimer having tWo bindIng siTes For.alpha..sUb.IiB.beTa..sub.3, reacTs wiTh activateD reCepTors fOunD On the SurfACe Of pLAteleTs. ThE Binding of.ALpHa..sUB.iIB.beta..sub.3 recEPTOrs On adjAceNT plateLets, By fibrinogen leads TO crosslinking aNd is CONsiDerED to bE a Major factor in pLatElET AggregatIoN. Compounds wHich
 structure may be typicall y on the o rderoftwe nt y to  thi rty feet long, andpotentially can be hun dreds  o f  fee t  i n len gth whe n  t h e  pr oc es s i sp er fecte d f or comm ercial tra nsp or t aircraft.P ar ts of this  si ze are diffi cul t to p ro duc e  with  pe rfect  flatn e ss. In stead, th et ypical part ma y ha ve v arious combinatio n so f inconsistenc ies be yo n dd e sig n t olerance.Ap plyin g  heat t o  t h e int e rface by elec trically he a tin g thesu sce p tor in  conn ec t ion  with press ureon the pa rts te n ds to f l atten t he inc ons ist enci e s,  b utth e  ti m enee d edto achie ve  f ull i ntim a t e cont act  wit h the  use of heatand  pre s sur e may  be e xces si ve, a nd can  lead  t o undesirable r esul ts.
An ex ist in g s ol ution for in cre asi ng therate of pro du c t i on  of thermoplasticco m p on ents isto bui l dmo r e autocl av esandr a te to olin g  w hen a cr itical ra te  of the  c urrent  t ool s i s rea c hed,  or to  cap the  prod u ction capabili t ies of a manu f ac t u ri n g fa cil ity at a ce rtai n  rat e th a tdoe s  notrequi re bu i lding new tooling.Th e exis tingautoclave bas ed systems h a ve an in here n tl imit at whichprodu ction rate s  above t hat c riticalrate will t rigger a  la rge  in cre m e nt  of capital e x p endi tu res tobeincurre d a lon g w ith  a  lag time  require dto  o bt ain  thec apital,in sta ll  th e equ i pment,  andensu re  t h e e quipmen t  i s func ti on al.Acc or dingl y, t h ere  is a n eed for a n a p para tu sand a s ystem that fa ci litates ra pi d f abrica t i on of la rge thermoplastic compo n ents, a s w ell a s arelated m eth od. In teg r ins ar e a fa milyof  he t e rodim e r ic  pr ot eins which g ene rally  m edia te cell  adhesion. Typical ofsuch proteins  ar e th e vi tro n ec t inre c ept o r  (an.alpha..sub .V.beta..s ub . 3heterodime r ) a nd  the fi brinoge n rec e ptor (a n.alpha.. sub.IIb.b et a..s u b .3heterodime r). Thenatural l i gands of  thes e r ecepto rs  (e .g.,vitron e cti n and  fibri no gen) h ave b ee n foundto share a common -Arg- Gly-As p- am ino  acid seq uen c e,which app ears  to be cri tic alfor b ind i ng. I n fa c t,  ma n y ofthei ntegrin r e ce pto r s  a ppear to cr o s s  re act w ith ligand s wh ich possess sucha n amino acid s eque n c e.For inst an ce, the.alpha. .su b. I I b.beta.. su b.3 recepto r reacts  w i th fi bronec tin an d vitro n e ct i n, thr ombo spo ndin andvon  W i llebran dfa c tor, a s we ll  as fi brinog e n. F u n ctionally fibrin ogen, a  dime r  ha vingtw o bindi n g si tes for.al pha..sub.II b.beta ..su b.3,reactswi th act iva te d receptor s  found on  thesurface  o f pl ate lets.Theb i nding  of. al pha ..sub.IIb . b et a .. su b .3rece ptors  o n ad jacent pl a telets,byf ibrinog en  le a d s to c r os s l inking and  is  cons i d ered to be a ma j or facto r in p latele t aggre g ati on . Compo und s which
 structure_may be_typically on the order_of twenty_to_thirty feet_long,_and potentially can_be hundreds of_feet in length when_the process is_perfected_for commercial transport aircraft. Parts of this size are difficult to produce with perfect_flatness._Instead, the_typical_part_may have various combinations of_inconsistencies beyond design tolerance. Applying_heat to_the interface by electrically heating the susceptor in_connection_with pressure on_the parts tends to flatten the inconsistencies, but the_time needed to achieve full intimate_contact with the_use_of_heat and pressure may_be excessive, and can lead to_undesirable results.
An existing solution for increasing_the rate of production of thermoplastic components_is to build more autoclaves and_rate tooling when a critical_rate of_the current tools is reached,_or to cap_the production_capabilities of a_manufacturing facility at a certain rate_that does not_require building new tooling. The existing_autoclave_based systems have_an_inherent_limit at_which production rates_above_that critical_rate_will trigger a large increment of_capital_expenditures to be incurred along with a_lag time required to_obtain_the capital, install the_equipment, and ensure the equipment_is functional.
Accordingly, there is a need_for an_apparatus and_a system that facilitates rapid fabrication of large thermoplastic components, as_well as a related method. Integrins_are a family of_heterodimeric proteins_which_generally mediate cell_adhesion._Typical of_such proteins are the vitronectin receptor (an.alpha..sub.V.beta..sub.3_heterodimer) and_the fibrinogen receptor (an.alpha..sub.IIb.beta..sub.3 heterodimer). The_natural ligands of these_receptors_(e.g., vitronectin and fibrinogen) have been_found to share a common -Arg-Gly-Asp-_amino acid sequence, which appears_to_be_critical for binding. In fact,_many of the integrin receptors appear_to cross react_with ligands which possess such an amino_acid_sequence. For instance, the.alpha..sub.IIb.beta..sub.3 receptor reacts_with_fibronectin and vitronectin, thrombospondin and von_Willebrand_factor,_as well as fibrinogen. Functionally_fibrinogen, a dimer having two binding_sites for.alpha..sub.IIb.beta..sub.3, reacts with activated receptors found on the_surface of platelets._The binding of.alpha..sub.IIb.beta..sub.3 receptors on_adjacent_platelets,_by fibrinogen leads to crosslinking and is considered to be_a major_factor in platelet_aggregation. Compounds which