 of view of the reference detector are averaged, and the averaged timing value is determined as a time delay value relative to the reference detector. A detector adjoining the reference detector is regarded as a new reference, and a time delay value is determined similarly. A difference between the time delay value determined first and the time delay value determined next is determined to serve as a reference correction value. Timing correction is carried out by uniforming times using the reference correction value. Subsequently, similar computations are carried out for successively adjoining detectors, to complete the timing correction when one circuit has been made of the ring.
The signal timing correction method described in Patent Document 3 noted above is as follows. Simulated signals outputted from a simulated signal generating device are inputted to a plurality of signal processing devices (signal processing units), respectively. Based on output of each signal processing device, calibration data is generated to carry out timing correction.
In Patent Document 4 noted above, a TOF type PET apparatus has incorporated therein DOI detectors which can discriminate light source positions having caused an interaction in a depth direction (DOI: Depth of Interaction). The DOI detectors are constructed of respective scintillator elements stacked in the depth direction of radiation (gamma rays here). Coordinates information in the depth direction in which the interaction has occurred and a transverse direction (direction parallel to the plane of incidence) is derived from centroid computations. Detection time correction information corresponding to this coordinates information is written to and stored in a table. By referring to the detection time correction information, information accuracy of flight time differences is improved.
[Patent Document 1]
Patent Publication H6-19436
[Patent Document 2]
Specification of U.S. Pat. No. 3,343,122
[Patent Document 3]
Unexamined Patent Publication No. 2006-90827
[Patent Document 4]
Unexamined Patent Publication No. 2008-51701 The present invention relates to antibodies, compositions and methods for diagnosing and treating inflammation. More particularly, the present invention relates to the use of scavenger receptor inhibitors in treatment of an inflammatory response and to methods of diagnosing an inflammatory response via detection of autoantibodies directed at scavenger receptors.
Inflammation is a physiological condition characterized in the acute form by the classical signs of pain, heat, redness, swelling and loss of function. Inflammation often accompanies diseases such as Multiple Sclerosis (MS), osteoarthritis, Inflammatory Bowl Disease (IBD) including Crohn's disease and ulcerative colitis, Rhe
of view of the reference detector are averaged, and the averaged timing value is determine as a meter delay value relative to the reference detector. A detector adjoining the citation detector is regarded as a new reference book, and a prison term delay value is determined similarly. A deviation between the time delay value determined foremost and the time delay value determined next is determined to serve as a reference book correction value. Timing discipline is carried out by uniforming time use the reference correction value. Subsequently, similar calculation are carried out for successively adjoining detectors, to complete the timing correction when one tour has been made of the ring. 
 The signal timing correction method described in Patent Document 3 note above is as follows. Simulated signals outputted from a simulated signal generating device are inputted to a plurality of signal processing devices (signal processing units), respectively. Based on output of each signal processing device, calibration data is generated to carry out timing correction. 
 In Patent Document 4 noted above, a TOF type PET apparatus has integrate therein DOI detectors which can discriminate light generator position having caused an interaction in a depth management (DOI: astuteness of Interaction). The DOI detectors are constructed of respective scintillator elements stack in the depth direction of radiation (gamma rays here). Coordinates information in the depth direction in which the interaction has occurred and a transverse management (focus parallel to the plane of incidence) is derived from centroid computations. Detection time discipline information corresponding to this coordinates information is written to and stored in a table. By referring to the detection prison term correction data, information accuracy of flight time differences is improved. 
 [ Patent Document 1 ] 
 Patent Publication H6 - 19436 
 [ Patent Document 2 ] 
 Specification of U.S. Pat. nobelium. 3,343,122 
 [ Patent Document 3 ] 
 Unexamined Patent Publication No. 2006 - 90827 
 [ Patent Document 4 ] 
 Unexamined Patent Publication No. 2008 - 51701 The present invention relates to antibodies, compositions and methods for diagnose and treating inflammation. More particularly, the present invention relates to the use of magpie receptor inhibitors in treatment of an incendiary response and to methods of diagnosing an inflammatory reply via signal detection of autoantibodies directed at magpie receptors. 
 Inflammation is a physiological condition characterize in the acute form by the classical augury of pain, heat, redness, swelling and loss of function. excitement frequently attach to diseases such as Multiple Sclerosis (MS), osteoarthritis, Inflammatory Bowl Disease (IBD) including Crohn's disease and ulcerative colitis, Rhe
 of view of the reference dttector are averaywd, and the aberaged giming value is determined ad q timt delay value relatkve to thv referenxe dttector. A detectoc adjoinlug ths refzrxnce detector ix regarded as a new refesevcz, and a time delay value is determinqd simikagly. A differense bttwqen fhe time delay value determined fidst and the time delsy value determined next id dehermined to serve ws a referebce sirrection vauue. Timing correction js carried out by uniforming tioes uxing the rgywrejwe correctiin vajue. Subsequeknly, simhlar cokputations are cacriee out for successivelb adjoining detectorf, to compnece the timing correctuob whet ona cifxuig hzs bsen mafe kf the rinf.
The signal timing correction keeyod described in Paeegt Document 3 noted above is as follows. Vimhlated signals outputtee from a simulated sihnal genewating device are inputted to a plurality of signdl prkzeswikg ddcifes (signal processing units), respectively. Baseq om putput of each signal provedsogg device, calkbration sata is generated ho carri out riming cowrecyion.
In Patent Document 4 notwd above, a TJD type PET apparatbs has incor'oratec thetein DOI detectors whick can siscriminatf light skjrce positions hxvikg waused an interaction in a depth dicectipn (DOI: Aeptn of Igteraction). The DOI detectors are clnstrocted mf respectlve scintillator elements stackxv in the deptn girvction of radistion (gamma rwys here). Coordnnates iuformagion in thv depth dmrection in rhich the intataction has orcurred agd a trabsverse airection (direvtion parcjlel to the plane of ikcidevde) is derived fxun centroid compitagiogs. Dxtectymn time corractiun kmformxtion correwoondong to this coordinades jnformation is wriytcn to and stored yn a table. By referring to the fetecvion tmme cotrestion information, information zccuracy lf nlight time dyffevencgs is improred.
[Patent Document 1]
Patent Publication H6-19436
[Petent Document 2]
Specificqtion of U.S. Pat. No. 3,343,122
[Kattnt Document 3]
Nnexamyned Patett Publication No. 2006-90827
[Parent Document 4]
Unewamined Patent Publicafion Nm. 2008-51701 Thf present invention relates to antibodies, compositions and methods for diqgnosiig and treatihg imflamkaciou. More [artmcnlarly, the presenn invention relates to the use oh scavenges xeceptor inhibitors in treatmrng of an inflaomatory response and to jethods pf diagnosing an inflammatory rrsponse via detection of autoantubodiss dirvdtxd at scavenger receltors.
Iuflammqtion iw a ihysiological zoncibion charaftermzeb in the acute form by the classixal sitnd of pain, heat, rxdness, swelllnn and moss os function. Inflajmatjln ofjen accompaniex diseases sucn as Multiple Sclerovif (MS), osteoartheptis, Inflammajory Bown Disease (IBV) including Wrohn's disease and ulcerative colitis, Rhe
of view of the reference detector are the timing value determined as a the detector. A detector the reference detector regarded as a new reference, and time delay value is determined similarly. A difference between the time delay value first and the time delay value determined next is determined to serve as reference value. correction carried out by uniforming times using the reference correction value. Subsequently, similar computations are carried out successively adjoining detectors, to complete the timing correction one circuit has been of the ring. The signal correction described in Document noted is as follows. signals outputted from a simulated signal generating device are inputted to a plurality of signal processing devices processing units), on output each processing calibration data is carry out timing correction. In Patent above, a TOF type PET apparatus has incorporated DOI detectors can discriminate light source positions having an interaction in a depth direction (DOI: Depth Interaction). The DOI detectors are constructed of respective scintillator elements stacked in the depth direction (gamma rays here). Coordinates in the depth in the has and a direction (direction parallel to the plane of incidence) is derived from computations. Detection time correction information corresponding to this coordinates information to stored in a By referring to the time information, information accuracy of differences improved. Patent H6-19436 Document 2] Specification of Pat. No. 3,343,122 [Patent Document Unexamined Patent Publication No. Patent Publication No. 2008-51701 The present invention relates antibodies, compositions and methods for diagnosing and inflammation. More particularly, the present invention relates to the use of scavenger inhibitors in an inflammatory response and to methods of diagnosing inflammatory response via detection autoantibodies directed at scavenger receptors. Inflammation is a physiological characterized the acute by the classical of pain, heat, swelling and loss Inflammation often diseases as osteoarthritis, Inflammatory Bowl Disease (IBD) including disease ulcerative colitis, Rhe
 of view of the reference detecTor are averAged, aNd tHe aVeRageD timIng value is deteRMineD as a time delay value relaTive tO tHE refEReNce deTector. A DEtECTor AdJoIniNg THe ReferEncE detectOr is regardEd aS a New reference, ANd A time delay ValUe is determinEd sImilarLy. a diFFerenCe bEtweeN the tiME delay Value deteRmINed firST and the TIMe DelaY value determined nEXt IS determined to sErve as A rEFeRENce CorRection valUe. timinG CorrectIOn IS CArrIEd out by uniforMing times usINg tHe refeReNce COrrectIon vaLuE. subSequently, siMilaR computatIons arE Carried OUt for suCcessiVelY adJoinINg DeTecToRS, to COmPleTE thE timing cOrReCtion When ONE CIrcuIt hAs beEn madE of the ring.
The SigNal tIMinG corrEctioN metHoD descRibed iN PateNt document 3 noted abOve iS as followS. SiMuLatEd SignaLS outpuTteD frOm a simuLated siGNal GeNERAtIng device are inputtEd TO A pLurality Of signAL pRoCEssing deViCes (SignAL ProceSsinG UnIts), respeCtivelY. baSeD on outpUt Of each SiGnaL prOcessINg deVice, caLibratioN data IS generated to caRRy out timing coRReCTIoN.
in PaTenT Document 4 noTed aBOve, a tOF tYPe pET APparaTus haS iNCoRPorated therein DOI deTeCtors wHich cAn discriminatE light sourCE POsitions HaviNG cAUsed an interactIon in A depth direCTion (DOI: DEpth oF InteracTion). The DOi DEtectors Are ConStrUctED Of Respective sciNTIllaToR elemenTs sTacked iN thE dePth DirEcTion of radIation (gaMmA rAyS hEre). coordINates infOrMatIoN in The dePTh direCtion In whIcH tHE inTeractiON hAS OccuRrEd And a TraNsVerse DireCTioN (directIon parallEl tO The pLaNe Of incidEnce) is derived FrOm centroid CoMpuTationS. dEtection Time correction informatiON corresPonDing tO thiS coordinaTes InformAtiON is wriTten to And stOrEd iN A Table. bY ReFerRiNg to the detECTioN time CoRrecTion infOrmation, informatioN AccUracy of flight TimE difFEReNceS Is IMprOvED.
[PaTENt Document 1]
PatenT PublicatiOn h6-19436
[paTent DocumeNT 2]
SpEcIficatiOn of U.S. PAt. No. 3,343,122
[PATent DocUment 3]
UnexAmined PatEnT PubLICatIon No. 2006-90827
[PatenT DocumenT 4]
UnexaminED PateNT PUblicAtiOn No. 2008-51701 ThE pResEnt inVentioN RelAtes tO antibOdIes, comPositIoNs and metHods for diagnosing and treAting iNflamMatIon. More paRtiCUlaRly, the preSent Invention rElaTes To the Use OF scavEngeR ReCepTOr inhIbitORs in treatMEnT of AN InFlammatory rESPOnsE and tO meTHods of DiagNosing an inflammatORy response via dEtecTIOn oF auTOantIbOdies directed aT scAvENGer recepToRs.
InflammatIon is a phYsIOlogiCal conDition CharactERIzED in the AcutE foRm by the clAssIcAL signs oF pAiN, Heat, reDnesS, sWellinG and loSS of fUNCtion. InflammatioN ofteN ACcompANieS diseAsEs such aS multIple ScleroSis (MS), osteoaRthritIs, InFlammAtory BoWl diseasE (IBd) iNcluding CrOHn's diseasE and uLceratiVe ColiTis, rhe
 of view of the referencedetector a re av era ged ,andtheaveraged timin g  val ue is determined as atimede l ay v a lu e rel ative t o  t h e  re fe re nce  d e te ctor.  Adetecto r adjoinin g t he  reference d e te ctor is re gar ded as a new  re ferenc e,  an d  a ti medelay  value is det ermined s im i larly. A diffe r e nc e be tween the time de l ay value determin ed fir st an d the  ti me delay v al ue de t ermined ne x t isd etermined toserve as ar efe renceco rre c tion v alue.  T i min g correctio n is  carriedout by uniform i ng time s usin g t herefe r en ce  co rr e cti o nval u e.Subseque nt ly , sim ilar c o m puta tio ns a re ca rried out for  su cces s ive ly ad joini ng d et ector s, tocompl et e the timing co rrec tion when  on ecir cu it ha s  beenmad e o f the r ing.
Th e  si gn a l ti ming correction me th o d  d escribed  in Pa t en tD ocument3not ed a b o ve is  asf ol lows. Si mulate d  s ig nals ou tp uttedfr oma s imula t ed s ignalgenerati ng de v ice are inputt e d to a plural i ty o fs igna l p rocessing d evic e s (s igna l  p roc e ssing  unit s) ,  r e spectively. Based o noutput  of e ach signal pr ocessing d e v i ce, cali brat i on data is genera ted t o carry ou t  timingcorre ction.
I n PatentD o cument 4  no ted  ab ove , aTOF type PETa p para tu s has i nco rporate d t her ein  DO Idetectors  which c an  d is cr imi natel ight sou rc e p os iti ons h a ving c aused  anin te r act ion ina  d e p th d ir ec tion  (D OI : Dep th o f  In teracti on). TheDOI dete ct or s are c onstructed of  r espectivesc int illato r elements  stacked in the depth d i rection  of  radi atio n (gammaray s here ).C oordin ates i nform at ion i n the d ep thdi rection in w hic h the  i nter actionhas occurred and a tra nsverse direc tio n (d i r ec tio n  p a ral le l  to t he plane of inc idence) is  d e ri ved from c e ntr oi d compu tations . Det e ction t ime corre ction inf or mati o n  co rrespondin g to thi s coordin a tes i n fo rmati onis wri tt ento an d stor e d i n a t able.By  refer ringto  the det ection time correctioninform ation , i nformatio n a c cur acy of fl ight  time diff ere nce s isimp r oved. 
[Pa t en t D o cumen t 1] Patent Pu b li cat i o nH6-19436
[P a t e ntDocum ent 2]
Spe cifi cation of U.S. Pa t . No. 3,343,12 2
[P a t ent  Do c umen t3]
UnexaminedPat en t Publicat io n No. 2006- 90827
[P at e nt Do cument  4]
Un examine d Pa t ent Pu blic ati on No. 20 08- 51 7 01 Thepr es e nt inv enti on  relat es toa ntib o d ies, composition s and m ethod s  fo r dia gn osing a n d tr eating inf lammation.More p arti cular ly, the  p resent  in ve ntion rela t es to the  useof scav en gerrec eptorinhi b i torsin t re atm ent of an i nf l am ma t ory  res ponse  a nd t o methods of diagn osi n g an in fl amm a t ory re s po n s e via dete cti on of a utoantibod i es d i re c ted a t scav engerrecepto r s.In flammat ion i s a physi ologicalc ond it ioncharacte ri zedin  th eacute form by t he class ical sig n s  of pa in, heat ,  redne ss , swelling a nd lo ss of func t i on.  Inflam m ati onoft en a cco mpan i es diseases such as Mult iple  Scle r osi s (MS ), os te oarthrit i s, I nflammat o ry Bowl Disea se (IBD) includ i ngC rohn 'sd is ea se and ul cer a tivecoli tis , Rh e
 of_view of_the reference detector are_averaged, and_the_averaged timing_value_is determined as_a time delay_value relative to the_reference detector. A_detector_adjoining the reference detector is regarded as a new reference, and a time delay_value_is determined_similarly._A_difference between the time delay_value determined first and the_time delay_value determined next is determined to serve as_a_reference correction value._Timing correction is carried out by uniforming times using_the reference correction value. Subsequently, similar_computations are carried_out_for_successively adjoining detectors, to_complete the timing correction when one_circuit has been made of the_ring.
The signal timing correction method described in_Patent Document 3 noted above is_as follows. Simulated signals outputted_from a_simulated signal generating device are_inputted to a_plurality of_signal processing devices_(signal processing units), respectively. Based on_output of each_signal processing device, calibration data is_generated_to carry out_timing_correction.
In_Patent Document_4 noted above,_a_TOF type_PET_apparatus has incorporated therein DOI detectors_which_can discriminate light source positions having caused_an interaction in a_depth_direction (DOI: Depth of_Interaction). The DOI detectors are_constructed of respective scintillator elements stacked_in the_depth direction_of radiation (gamma rays here). Coordinates information in the depth direction_in which the interaction has occurred_and a transverse direction_(direction parallel_to_the plane of_incidence)_is derived_from centroid computations. Detection time correction information_corresponding to_this coordinates information is written to_and stored in a_table._By referring to the detection time_correction information, information accuracy of flight_time differences is improved.
[Patent Document_1]
Patent_Publication_H6-19436
[Patent Document 2]
Specification of U.S._Pat. No. 3,343,122
[Patent Document 3]
Unexamined Patent_Publication No. 2006-90827
[Patent_Document 4]
Unexamined Patent Publication No. 2008-51701 The_present_invention relates to antibodies, compositions and_methods_for diagnosing and treating inflammation. More_particularly,_the_present invention relates to the_use of scavenger receptor inhibitors in_treatment of an inflammatory response and to methods of_diagnosing an inflammatory_response via detection of autoantibodies_directed_at_scavenger receptors.
Inflammation is a physiological condition characterized in the acute_form by_the classical signs_of pain, heat, redness, swelling and loss of function. Inflammation_often accompanies diseases such as Multiple Sclerosis_(MS), osteoarthritis, Inflammatory Bowl Disease (IBD) including Crohn's disease and ulcerative_colitis, Rhe