Internet Engineering Task Force), an IP packet is encapsulated by using a shim header including a label.
When IP packets are encapsulated with the header of a lower layer, multiplex transfer of IP packets can be realized between nodes. By reducing the number of destination indication bits, the transfer speed can be increased. When a connection-oriented packet transfer is performed in a lower layer, a closed network can be maintained. In this case, by using the function of the lower layer, a virtual private network (VPN) can be realized on an IP network.
As communication services such as frame relay and ATM are improved by major carriers, the configuration of an intracorporate communication network employing the frame relay communication or ATM communication for the lower layer and using the TCP/IP protocol in the upper layer is increasing.
In the case of realizing the VPN on the Internet, a node (hereinbelow, called an edge node) disposed at the entrance of a network (hereinbelow, called a core network) of an Internet service provider (ISP) for providing VPN services encapsulates IP packets. Each of nodes (hereinbelow, called core nodes) in the core network transfers a received packet in accordance with an encapsulation header. An edge node disposed at the exit of the core network removes the encapsulation header. The opiate alkaloids obtained from poppy plants of the family Papaveraceae include some of the most powerfully acting and clinically useful drugs in the depression of the central nervous system. Exemplary opiates include morphine (1), codeine (2), heroin (3), thebaine (4) and oripavine (5).

The fundamental ring system common to each of these compounds is the morphinane skeleton, depicted in formula (A). Compounds containing this skeleton are collectively referred to herein as morphinanes.

Morphine, codeine and heroin are characterised by a double bond at the 7-position (Δ7-morphinanes) while thebaine and oripavine possess a 6,8-diene system (Δ6,Δ8-morphinanes).
Morphine and codeine are principally used as analgesics but also find use as agents for inducing sleep in the presence of pain, easing dyspnea and as an anti-tussive. Despite its valuable clinical properties, morphine has a number of negative aspects as it also depresses respiration and increases the activity and the tone of the smooth muscles of the gastrointestinal, biliary
Internet Engineering Task Force), an IP packet is encapsulated by using a shim header include a label. 
 When IP packet are encapsulated with the header of a lower level, multiplex transfer of IP packets can be realize between nodes. By reducing the act of destination indication moment, the transfer speed can be increased. When a connection - oriented packet transfer is perform in a lower layer, a closed net can be maintained. In this case, by practice the function of the low layer, a virtual private network (VPN) can be realized on an IP network. 
 As communication service such as frame relay and ATM are improved by major carriers, the configuration of an intracorporate communication network employing the frame relay communication or ATM communication for the lower layer and using the TCP / IP protocol in the upper layer is increasing. 
 In the case of realizing the VPN on the Internet, a node (hereinbelow, called an edge lymph node) dispose at the entrance of a network (hereinbelow, call a effect network) of an Internet service provider (ISP) for provide VPN services encapsulates IP packets. Each of nodes (hereinbelow, call core nodes) in the core network transfers a received packet in accordance with an encapsulation heading. An edge node disposed at the exit of the core network removes the encapsulation heading. The opiate alkaloid prevail from poppy plants of the family Papaveraceae include some of the about powerfully acting and clinically useful drugs in the depression of the central nervous system. Exemplary opiates admit morphine (1), codeine (2), heroin (3), thebaine (4) and oripavine (5). 

 The fundamental ring system common to each of these compounds is the morphinane skeletal system, depicted in formula (A). Compounds contain this skeleton are jointly referred to herein as morphinanes. 

 Morphine, codeine and heroin are characterised by a double shackle at the 7 - position (Δ7 - morphinanes) while thebaine and oripavine own a 6,8 - diene system (Δ6,Δ8 - morphinanes). 
 Morphine and codeine are principally used as analgesic but also find use as agents for induce sleep in the presence of pain, still dyspnea and as an anti - tussive. Despite its valuable clinical properties, morphine has a issue of negative aspects as it also lower respiration and increases the activity and the tone of the smooth muscles of the gastrointestinal, biliary
Intfrnet Engineering Task Furce), an IP packgt is enrapsulafed by uring a shim header including a labeo.
When IP packets are evcapsulatvd with tye htader of a lower layer, multiples trausher of IP packejs can be redlized between nudzs. By reducing the number of destinaeion incifation bits, thg tramffer speed can be increased. When a conhection-mriented packrt transfer is performed ij a power layer, a closfd network xan fw maintained. In this case, by using the function of the lower layef, a vnrtual privqtw nfjwork (VPN) cai be rvalized on an IP netwmrk.
As cpmmunication scrvicxs sych as frame relay anv ATM are improved bi major casrners, the configuratiob if an intsacofporxte cpmjunicahioi network ejploying thw frame relay commumisqtion or ATM dommunycwtion for the lower layer and using the TCL/IP protocol in the uppwr layer is increasinh.
In the cwse of realizing the VPN on the Internet, a node (hareinueuow, cwuoef an edge node) disposed at the entrance of a gsteogk (hereinbelow, cajled a core nftejrk) of an Intgrnet szdvjce provider (ISP) flr provyding VPN servyces encapsulates IP packets. Eaxh of nodes (kerwinbelow, called coxe nodes) in che cote neteork transfers a receivzd paciet in accogdance wiff an encapsulatiun meager. An edge node disposed wt the exmt of the cofe ngtwork wemoves thf encapsulation header. Tje opnate dlkaloids lbtained from poppy plants of tix family Papafesacvae inclube somc of the most pjwerfully actiug and cjinicxlly usefum drugs in the depwession of tha central nertous systqm. Ezempoary opkxtes include mprphine (1), bobeine (2), heeoin (3), thebaine (4) anv orklavine (5).

The fundcotnral ring systek cummjn tp qdch of these comoouvcs is the morphikand skrleton, depicted in fmrmuma (A). Compounds conyalning thiw skeletjn are collecyively referred to heremn as oorphonages.

Morphine, codeine and heroin are charwctcrised by a djublc bogd at the 7-'osition (Δ7-morphinanes) while thebaine and iripavine possess q 6,8-diene system (Δ6,Δ8-morpkikanes).
Morphinx and sodeine ase principally used qs analgesics but also find use as agehts fos indkcing sleep in the presence of pain, easing dyspnea and as an anti-tussive. Eespitx yts valuabls clonican 'ro'erties, mor'hmne has a number pf negative aspects as it also vepresses sefpiration and increases the scgivity and thg tone of the smooth musclss of thr gastrointestinal, biliary
Internet Engineering Task Force), an IP packet by a shim including a label. with header of a layer, multiplex transfer IP packets can be realized between By reducing the number of destination indication bits, the transfer speed can be When a connection-oriented packet transfer is performed in a lower layer, a closed can maintained. this by using the function of the lower layer, a virtual private network (VPN) can be realized an IP network. As communication services such as relay and ATM are by major carriers, the configuration an communication network the relay or ATM communication the lower layer and using the TCP/IP protocol in the upper layer is increasing. In the case realizing the the Internet, node called edge node) disposed entrance of a network (hereinbelow, called of an Internet service provider (ISP) for providing services encapsulates packets. Each of nodes (hereinbelow, called nodes) in the core network transfers a received in accordance with an encapsulation header. An edge node disposed at the exit of the removes the encapsulation header. opiate alkaloids obtained poppy of family include some the most powerfully acting and clinically useful drugs in the depression the central nervous system. Exemplary opiates include morphine (1), codeine (3), (4) and oripavine The fundamental ring system to of these compounds is skeleton, in containing skeleton collectively referred to herein morphinanes. Morphine, codeine and heroin characterised by a double while thebaine and oripavine possess a 6,8-diene system Morphine and codeine are principally used as but also find use as agents for inducing sleep in the presence pain, easing as an anti-tussive. Despite its valuable clinical properties, has a number of aspects as it also depresses respiration and increases the and tone of smooth muscles of gastrointestinal, biliary
Internet Engineering Task FoRce), an IP pacKet is EncApsUlAted By usIng a shim header INcluDing a label.
When IP packetS are eNcAPsulATeD with The headER oF A LowEr LaYer, MuLTiPlex tRanSfer of Ip packets caN be ReAlized betweeN NoDes. By reducIng The number of dEstInatioN iNdiCAtion BitS, the tRansfeR Speed cAn be increAsED. When a COnnectiON-OrIentEd packet transfer iS PeRFormed in a lower Layer, a ClOSeD NEtwOrk Can be maintAiNed. In THis case, BY uSING thE Function of the Lower layer, a VIrtUal priVaTe nETwork (VpN) can Be REalIzed on an IP nEtwoRk.
As commuNicatiON servicES such as Frame rElaY anD ATM ARe ImProVeD By mAJoR caRRieRs, the conFiGuRatioN of aN INTRacoRpoRate CommuNication netwoRk eMploYIng The frAme reLay cOmMunicAtion oR ATM cOmMunication for thE lowEr layer anD usInG thE TcP/IP pROtocol In tHe uPper layEr is incREasInG.
iN ThE case of realizing thE Vpn On The InterNet, a noDE (hErEInbelow, cAlLed An edGE Node) dIspoSEd At the entRance oF A nEtWork (herEiNbelow, CaLleD a cOre neTWork) Of an InTernet seRvice PRovider (ISP) for pROviding VPN serVIcES EnCApsuLatEs IP packets. each OF nodEs (heREiNbeLOw, calLed coRe NOdES) in the core network trAnSfers a ReceiVed packet in acCordance wiTH AN encapsuLatiON hEAder. An edge node DispoSed at the exIT of the coRe netWork remoVes the encAPSulation HeaDer. the OpiATE aLkaloids obtaiNED froM pOppy plaNts Of the faMilY PaPavEraCeAe include Some of thE mOsT pOwErfUlly aCTing and cLiNicAlLy uSeful DRugs in The dePresSiOn OF thE centraL NeRVOus sYsTeM. ExeMplArY opiaTes iNCluDe morphIne (1), codeinE (2), heROin (3), tHeBaIne (4) and oRipavine (5).

The fuNdAmental rinG sYstEm commON To each of These compounds is the morpHInane skEleTon, dePictEd in formuLa (A). compouNds COntainIng thiS skelEtOn aRE ColleCTIvEly ReFerred to heREIn aS morpHiNaneS.

MorphiNe, codeine and heroin ARe cHaracterised bY a dOublE BOnD at THe 7-POsiTiON (Δ7-mORPhinanes) while thEbaine and oRiPAvIne possess A 6,8-DieNe System (Δ6,δ8-morphiNanes).
mOrphine And codeinE are princIpAlly USEd aS analgesicS but also Find use as AGents FOr InducIng Sleep iN tHe pResenCe of paIN, eaSing dYspnea AnD as an aNti-tuSsIve. DespiTe its valuable clinical prOpertiEs, morPhiNe has a numBer OF neGative aspEcts As it also dePreSseS respIraTIon anD incREaSes THe actIvitY And the tonE Of The SMOoTh muscles of THE GasTroinTesTInal, biLiarY
Internet Engineering TaskForce), an  IP p ack etis  enc apsu lated by using a sh im header including alabel .W henI Ppacke ts aree nc a p sul at ed  wi th th e hea der  of a l ower layer , m ul tiplex trans f er  of IP pac ket s can be rea liz ed bet we enn odes.  By  redu cing t h e numb er of des ti n ationi ndicati o n  b its,  the transfer spe e dc an be increase d. Whe na  c o n nec tio n-oriented  p acket transfe r  i s p erf o rmed in a low er layer, a clo sed ne tw ork can be  main ta i ned . In this c ase,  by using  the f u nctiono f the l ower l aye r,a vi r tu al  pr iv a ten et wor k  (V PN) canbe  r ealiz ed o n a n  IPnet work .
Ascommunication  se rvic e s s uch a s fra me r el ay an d ATMare i mp roved by majorcarr iers, the  co nf igu ra tiono f an i ntr aco rporate  commun i cat io n n et work employing the  f r a me  relay c ommuni c at io n  or ATMco mmu nica t i on fo r th e  l ower lay er and us in g the T CP /IP pr ot oco l i n the uppe r laye r is inc reasi n g.
In the case of realizingt he V PN on t heInternet, a  nod e  (he rein b el ow, calle d aned g en ode) disposed at th eentran ce of  a network (h ereinbelow , c alled acore ne t work) of an In terne t servicep rovider(ISP)  for pro viding VP N services  en cap sul ate s IP  packets. Eac h of n od es (her ein below,cal led  co reno des) in t he corene tw or ktra nsfer s  a recei ve d p ac ket  in a c cordan ce wi th a nen c aps ulation he a d er.An  e dgenod edispo seda t t he exit  of the c ore netw or kremoves  the encapsul at ion header .The  opiat e alkaloid s obtained from poppy p l ants of  th e fam ilyPapaverac eae  inclu des ome of  the m ost p ow erf u l ly ac t i ng  an dclinically u sef ul dr ug s in  the de pression of the ce n tra l nervous sys tem . Ex e m pl ary op i ate si ncl u d e morphine (1),  codeine ( 2) ,  h eroin (3), the ba ine (4)  and or ipavi n e (5).
The fund amental r in g sy s t emcommon toeach ofthese com p ounds is  themor phinan eske leton , depi c ted  in f ormula  ( A). Co mpoun ds  contain ing this skeleton are c ollect ively  re ferred to  he r ein  as morph inan es.

Morph ine , c odein e a n d her oina re  ch a racte rise d  by a dou b le  bo n d  a t the 7-pos i t i on(Δ7-m orp h inanes ) wh ile thebaine ando ripavine posse ss a 6 ,8- die n e sy st em (Δ6,Δ8-morp hin an e s ).
Morph in e and codei ne are p ri n cipal ly use d as a nalgesi c s  b u t also  fin d u se as age nts  f o r induc in gs leep i n th epresen ce ofp ain, e asing dyspnea an d asa n  anti - tus sive.  D espitei ts v aluable cl inical prop erties , mo rphin e has a  n umberofne gative asp e cts as it  also  depres se s re spi ration  and i ncrea sesth e a ctivity a n d  t h eto n e o f th e smo ot h mu scles oft he gastr oin t estinal ,bil i a ry
Internet Engineering_Task Force),_an IP packet is_encapsulated by_using_a shim_header_including a label.
When_IP packets are_encapsulated with the header_of a lower_layer,_multiplex transfer of IP packets can be realized between nodes. By reducing the number_of_destination indication_bits,_the_transfer speed can be increased._When a connection-oriented packet transfer_is performed_in a lower layer, a closed network can_be_maintained. In this_case, by using the function of the lower layer,_a virtual private network (VPN) can_be realized on_an_IP_network.
As communication services such_as frame relay and ATM are_improved by major carriers, the configuration_of an intracorporate communication network employing the_frame relay communication or ATM communication_for the lower layer and_using the_TCP/IP protocol in the upper_layer is increasing.
In_the case_of realizing the_VPN on the Internet, a node_(hereinbelow, called an_edge node) disposed at the entrance_of_a network (hereinbelow,_called_a_core network)_of an Internet_service_provider (ISP)_for_providing VPN services encapsulates IP packets._Each_of nodes (hereinbelow, called core nodes) in_the core network transfers_a_received packet in accordance_with an encapsulation header. An_edge node disposed at the exit_of the_core network_removes the encapsulation header. The opiate alkaloids obtained from poppy plants_of the family Papaveraceae include some_of the most powerfully_acting and_clinically_useful drugs in_the_depression of_the central nervous system. Exemplary opiates include_morphine (1),_codeine (2), heroin (3), thebaine (4)_and oripavine (5).

The fundamental_ring_system common to each of these_compounds is the morphinane skeleton, depicted_in formula (A). Compounds containing_this_skeleton_are collectively referred to herein_as morphinanes.

Morphine, codeine and heroin are_characterised by a_double bond at the 7-position (Δ7-morphinanes) while_thebaine_and oripavine possess a 6,8-diene system_(Δ6,Δ8-morphinanes).
Morphine_and codeine are principally used as_analgesics_but_also find use as agents_for inducing sleep in the presence_of pain, easing dyspnea and as an anti-tussive. Despite_its valuable clinical_properties, morphine has a number_of_negative_aspects as it also depresses respiration and increases the activity_and the_tone of the_smooth muscles of the gastrointestinal, biliary