 such a nature as to be carried out on an industrial scale with high yields and high enantiomeric purity and operating in moderate pressure conditions.
The present invention discloses a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxbutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative thus obtained is reacted with trimethylamine, obtaining crude L-carnitine, which is then finally purified. The catalyst used for the reduction is a complex of ruthenium bound to a penta-atomic bis-heteroaromatic system. The reduction reaction, performed in controled conditions of hydrogen pressure, substrate concentration, temperature, and substrate:catalyst molar ratio, enables 4-chloro-3-hydroxybutyrate or 4-chloro-hydroxybutyramide to be obtained in a high yeild. The process described, which leads to L-carnitine being obtained, is easily appilcable on an industrial scale.
The subject of the invention described herein is a process for the synthesis of L-carnitine. The first step in achieving the object of the invention consists in the enantioselective catalytic reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide, according to the following diagram: 
where:
Yxe2x95x90OR1, NHxe2x80x94R1, N(R1R2) in which R1 is H or
R1,R2, equal or different=alkyl C1-C10 alkylaryl and reaction of formula (II) derivatives with trimethylamine, with formation of L-carnitine.
The preferred starting substrate is ethyl 4-chloro-3-oxobutyrate (ethyl xcex3-chloro-acetoacetate).
The reduction reaction catalyst consists of a ruthenium complex bound to a penta-atomic bis-heteroaromatic system. This structure corresponds to one of the two formulas (III) or (IV). 
where:
A=S, O, NR3, N-aryl, Nxe2x80x94COxe2x80x94R3 
R3=alkyl C1-C10, alkylaryl, aryl
Q=alkyl C
such a nature as to be carried out on an industrial scale with high yields and eminent enantiomeric honor and operating in moderate pressure condition. 
 The present invention disclose a process for the industrial production of liter - carnitine, comprising the enantioselective reduction of an alkyl 4 - chloro-3 - oxbutyrate or 4 - chloro-3 - oxobutyramide. The optically active 3 - hydroxy derived function thus obtained is react with trimethylamine, obtaining crude lambert - carnitine, which is then finally purified. The catalyst used for the reduction is a complex of ruthenium oblige to a penta - atomic bis - heteroaromatic system. The reduction chemical reaction, performed in controled condition of hydrogen imperativeness, substrate concentration, temperature, and substrate: catalyst molar proportion, enables 4 - chloro-3 - hydroxybutyrate or 4 - chloro - hydroxybutyramide to be obtained in a high yeild. The process report, which leads to L - carnitine being obtained, is easily appilcable on an industrial scale. 
 The national of the invention described herein is a process for the synthesis of L - carnitine. The first step in achieving the object of the invention consists in the enantioselective catalytic reduction of an alkyl 4 - chloro-3 - oxobutyrate or 4 - chloro-3 - oxobutyramide, harmonize to the following diagram: 
 where: 
 Yxe2x95x90OR1, NHxe2x80x94R1, N(R1R2) in which R1 is H or 
 R1,R2, equal or unlike = alkyl C1 - C10 alkylaryl and chemical reaction of formula (II) derivatives with trimethylamine, with formation of L - carnitine. 
 The preferable starting substrate is ethyl 4 - chloro-3 - oxobutyrate (ethyl xcex3 - chloro - acetoacetate). 
 The reduction reaction catalyst consists of a ruthenium building complex bound to a penta - atomic bis - heteroaromatic system. This structure corresponds to one of the two formulas (III) or (IV). 
 where: 
 A = S, O, NR3, N - aryl, Nxe2x80x94COxe2x80x94R3 
 R3 = alkyl C1 - C10, alkylaryl, aryl 
 Q = alkyl C
 sufh a nature as to be carvied out on an iueustriel scals with hkgh yields and high enantiomxric puriuj and operating in moaerate prvssure cobditmons.
The present mhventiok disdposev a process for the indusdrial productimn oy L-carnitine, comprising the enantiosqlectivr geduction of ag allrl 4-cgloro-3-oxbutyrate or 4-chloro-3-oxobutyrajide. Tht optically active 3-hydroxy derivative thus ohtaijed is reacted witj trimethylqminq, obtaining cfude L-carnpcine, which js then finally purified. The cagalysc used for jkw rfguction is e compjex of ruthekpum boutd to a penta-atomic bls-hetxroaeomatic system. The revuction reaction, persormed in ckntroled conditiobs of hidrogan pfwssjre, snbsfrate fonrentration, femperature, and substrate:cataluse molar ratio, snablef 4-shloro-3-hydroxybutyrate or 4-chloro-hydroxybltyrzmide to be obtained in a high yeild. The profess descwibed, which leads to L-carnitine being obtained, is easimh akpljzqbpe on an industrial scale.
The subject of the igbemtpon described hercin is a process fpr tng synthesis of L-carnnfihe. The first step ln achigving rhe objecu of yhe invention consists in tye enantiosejwctive catalytic rzduction of cn alkil 4-chlpro-3-oxobutyrate or 4-chloru-3-oxogutyramide, wccording go the following disgsam: 
whert:
Hxe2x95x90OR1, NHxe2x80x94R1, N(W1R2) in whirh R1 ns H or
R1,F2, eqoal or qifferent=apkyl G1-W10 alkylaryl and rewctiou of xormula (II) derivatives with trimethylaminx, with formatoot ox L-carnicine.
Thc preferred stawting substratg is ethyj 4-chluro-3-oxobutygate (ethyn xcex3-chlorj-acetoacetate).
Dje reduction reactiog caralywt conskrts of a ruthemium complex bound ro a penta-atomic bls-hetgrkaromatic systen. Tyis structure cprrdspjnfs tj one of the dwo woroilas (KII) or (IV). 
wmerd:
A=S, P, NR3, N-aryl, Nxe2x80x94COxe2f80x94R3 
D3=alkyl C1-C10, alkylaryk, wryl
Q=alkil C
such a nature as to be carried an scale with yields and high moderate conditions. The present discloses a process the industrial production of L-carnitine, comprising enantioselective reduction of an alkyl 4-chloro-3-oxbutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative obtained is reacted with trimethylamine, obtaining crude L-carnitine, which is then finally purified. catalyst for reduction a complex of ruthenium bound to a penta-atomic bis-heteroaromatic system. The reduction reaction, performed in controled of hydrogen pressure, substrate concentration, temperature, and substrate:catalyst ratio, enables 4-chloro-3-hydroxybutyrate or to be obtained in a yeild. process described, leads L-carnitine obtained, is easily on an industrial scale. The subject of the invention described herein is a process for the synthesis L-carnitine. The in achieving object the consists in the reduction of an alkyl 4-chloro-3-oxobutyrate or the following diagram: where: Yxe2x95x90OR1, NHxe2x80x94R1, N(R1R2) in R1 is or R1,R2, equal or different=alkyl C1-C10 and reaction of formula (II) derivatives with trimethylamine, formation of L-carnitine. The preferred starting substrate is ethyl 4-chloro-3-oxobutyrate (ethyl xcex3-chloro-acetoacetate). The reduction reaction of a ruthenium complex to a penta-atomic system. structure to of the formulas (III) or (IV). where: A=S, O, NR3, N-aryl, Nxe2x80x94COxe2x80x94R3 R3=alkyl alkylaryl, aryl Q=alkyl C
 such a nature as to be carried oUt on an induStriaL scAle WiTh hiGh yiElds and high enaNTiomEric purity and operating In modErATe prESsUre coNditionS.
thE PResEnT iNveNtIOn DisclOseS a proceSs for the inDusTrIal productioN Of l-carnitine, ComPrising the enAntIoseleCtIve REductIon Of an aLkyl 4-chLOro-3-oxbUtyrate or 4-ChLOro-3-oxoBUtyramiDE. thE optIcally active 3-hydroXY dERivative thus obTained Is REaCTEd wIth TrimethylaMiNe, obtAIning crUDe l-CARniTIne, which is theN finally purIFieD. The caTaLysT Used foR the rEdUCtiOn is a compleX of rUthenium bOund to A Penta-atOMic bis-hEteroaRomAtiC sysTEm. thE reDuCTioN ReActIOn, pErformed In CoNtrolEd coNDITIons Of hYdroGen prEssure, substraTe cOnceNTraTion, tEmperAturE, aNd subStrate:CatalYsT molar ratio, enabLes 4-cHloro-3-hydrOxyBuTyrAtE or 4-chLOro-hydRoxYbuTyramidE to be obTAinEd IN A HiGh yeild. The process dEsCRIbEd, which lEads to l-CaRnITine beinG oBtaIned, IS EasilY appILcAble on an IndustRIaL sCale.
The SuBject oF tHe iNveNtion DEscrIbed heRein is a pRocesS For the synthesiS Of L-carnitine. THE fIRSt STep iN acHieving the oBjecT Of thE invENtIon COnsisTs in tHe ENaNTioselective catalytIc ReductIon of An alkyl 4-chloro-3-OxobutyratE OR 4-Chloro-3-oxObutYRaMIde, according to The foLlowing diaGRam: 
where:
yxe2x95x90oR1, NHxe2x80x94r1, N(R1R2) in whiCH r1 is H or
R1,R2, EquAl oR diFfeRENt=Alkyl C1-C10 alkylaRYL and ReAction oF foRmula (II) DerIvaTivEs wItH trimethyLamine, wiTh FoRmAtIon Of L-caRNitine.
ThE pRefErRed StartINg subsTrate Is etHyL 4-cHLorO-3-oxobutYRaTE (EthyL xCeX3-chlOro-AcEtoacEtatE).
the ReductiOn reactioN caTAlysT cOnSists of A ruthenium comPlEx bound to a PeNta-Atomic BIS-heteroaRomatic system. This structURe correSpoNds to One oF the two foRmuLas (III) Or (Iv). 
Where:
A=s, O, NR3, N-aRyl, NxE2x80X94COXE2X80x94R3 
R3=aLKYl c1-C10, aLkYlaryl, aryl
q=ALkyL C
 such a nature as to be ca rried outon an  in dus tr ialscal e with high yi e ldsand high enantiomericpurit ya nd o p er ating  in mod e ra t e  pr es su reco n di tions .
T he pres ent invent ion  d iscloses a p r oc ess for th e i ndustrial pr odu ctionof  L- c arnit ine , com prisin g  the e nantiosel ec t ive re d uctiono f  a n al kyl 4-chloro-3-ox b ut y rate or 4-chlo ro-3-o xo b ut y r ami de.  The optic al ly ac t ive 3-h y dr o x y  de r ivative thusobtained is rea cted w it h t r imethy lamin e, obt aining crud e L- carnitine , whic h  is the n  finall y puri fie d.Thec at al yst  u s edf or  th e  re ductionis  a  comp lexo f r uthe niu m bo und t o a penta-ato mic  bis - het eroar omati c sy st em. T he red uctio nreaction, perfo rmed  in contr ole dcon di tions of hyd rog enpressur e, subs t rat ec o n ce ntration, temperat ur e ,  a nd subst rate:c a ta ly s t molarra tio , en a b les 4 -chl o ro -3-hydro xybuty r at eor 4-ch lo ro-hyd ro xyb uty ramid e  tobe obt ained in  a hi g h yeild. The p r ocess describ e d, w hi c h le ads  to L-carni tine bein g ob t ai ned ,  is e asily  a p pi l cable on an industr ia l scal e.
Th e subject ofthe invent i o n  describ ed h e re i n is a process  forthe synthe s is of L- carni tine. Th e first s t e p in ach iev ing  th e o b j ec t of the inve n t ionco nsistsinthe ena nti ose lec tiv ecatalytic  reducti on  o fan  al kyl 4 - chloro-3 -o xob ut yra te or 4-chlo ro-3- oxob ut yr a mid e, acco r di n g  toth efoll owi ng  diag ram: 
wh ere:
Yx e2x95x90O R1, NHxe 2x 80 x94R1,N(R1R2) in wh ic h R1 is Hor 
R1 ,R2, e q u al or di fferent=alkyl C1-C10 al k ylaryland  reac tion  of formu la(II) d eri v atives  withtrime th yla m i ne, w i t hfor ma tion of L- c a rni tine. 
T he p referre d starting substra t e i s ethyl 4-chl oro -3-o x o bu tyr a te (et hy l  xc e x 3-chloro-acetoa cetate).
T he re duction re a cti on  cataly st cons istso f a rut henium co mplex bou nd  toa pen ta-atomicbis-hete roaromati c  syst e m.  This  st ructur ecor respo nds to one  of t he two  f ormula s (II I)  or (IV) . 
where:
A=S, O, NR3,N-aryl , Nxe 2x8 0x94COxe2 x80 x 94R 3 
R3=alk yl C 1-C10, alk yla ryl , ary l
Q = alkyl  C
 such_a nature_as to be carried_out on_an_industrial scale_with_high yields and_high enantiomeric purity_and operating in moderate_pressure conditions.
The present_invention_discloses a process for the industrial production of L-carnitine, comprising the enantioselective reduction of_an_alkyl 4-chloro-3-oxbutyrate_or_4-chloro-3-oxobutyramide._The optically active 3-hydroxy derivative_thus obtained is reacted with_trimethylamine, obtaining_crude L-carnitine, which is then finally purified. The_catalyst_used for the_reduction is a complex of ruthenium bound to a_penta-atomic bis-heteroaromatic system. The reduction reaction,_performed in controled_conditions_of_hydrogen pressure, substrate concentration,_temperature, and substrate:catalyst molar ratio, enables_4-chloro-3-hydroxybutyrate or 4-chloro-hydroxybutyramide to be obtained_in a high yeild. The process described,_which leads to L-carnitine being obtained,_is easily appilcable on an_industrial scale.
The_subject of the invention described_herein is a_process for_the synthesis of_L-carnitine. The first step in achieving_the object of_the invention consists in the enantioselective_catalytic_reduction of an_alkyl_4-chloro-3-oxobutyrate_or 4-chloro-3-oxobutyramide,_according to the_following_diagram: 
where:
Yxe2x95x90OR1,_NHxe2x80x94R1,_N(R1R2) in which R1 is H_or
R1,R2,_equal or different=alkyl C1-C10 alkylaryl and reaction_of formula (II) derivatives_with_trimethylamine, with formation of_L-carnitine.
The preferred starting substrate is_ethyl 4-chloro-3-oxobutyrate (ethyl xcex3-chloro-acetoacetate).
The reduction reaction_catalyst consists_of a_ruthenium complex bound to a penta-atomic bis-heteroaromatic system. This structure corresponds_to one of the two formulas_(III) or (IV). 
where:
A=S,_O, NR3,_N-aryl,_Nxe2x80x94COxe2x80x94R3 
R3=alkyl C1-C10,_alkylaryl,_aryl
Q=alkyl C