, crystallite cellulose, starch, polyvinylpyrrolidone, or magnesium metasilicate/aluminate. According to the customary method, the composition may contain additives other than the inert diluents, for example, lubricants such as magnesium stearate, disintegrants such as calcium carboxymethylcellulose, and solution adjuvants such as glutamic acid or aspartic acid. Tablets or pills may, if desired, be coated with a sugar coating or a gastric-soluble or enteric-soluble film comprising sucrose, gelatin, hydroxypropyl methylcellulose phthalate or the like. Alternatively, the tablets or pills may be coated with two or more layers. Further, a capsule of an absorbable substance, such as gelatin, is also included.
The liquid composition for oral administration includes pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs, and may contain generally used inert diluents, such as purified water and ethanol. This composition may contain, in addition to the inert diluents, adjuvants such as wetting agents or suspending agents, sweetening agents, flavoring agents, aromas, and preservatives.
The injection for parenteral administration contain sterile aqueous or nonaqueous solubilizing agents, suspending agents, or emulsifying agents. Examples of the aqueous solubilizing agents and suspending agents are water for injection, and physiological saline for injection. Examples of the nonaqueous solubilizing agents and suspending agents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, alcohols such as ethanol, and POLYSORBATE 80 (registered trademark). Such a composition may further contain adjuvants, such as preservatives, wetting agents, emulsifying agents, dispersing agents, stabilizers (e.g., lactose), and solution adjuvants (e.g., glutamic acid and aspartic acid). These agents can be sterilized by ordinary sterilizing methods, such as filtration sterilization with a microfiltration membrane, heating sterilization such as moist heat sterilization, or incorporation of a bactericide. Alternatively, a sterile solid composition is produced, and can be used after being dissolved in sterile water or a sterile solvent for injection before being used.
Other pharmaceutical compositions for parenteral administration contain at least one of the compounds of the invention as an active ingredient. They include liquids for external use, ointments, liniments, suppositories, trans
, crystallite cellulose, starch, polyvinylpyrrolidone, or magnesium metasilicate / aluminate. According to the customary method, the composition may control additive other than the inert diluents, for case, lubricant such as magnesium stearate, disintegrants such as calcium carboxymethylcellulose, and solution adjuvants such as glutamic acid or aspartic acid. Tablets or pills may, if desire, be coated with a sugar application or a gastric - soluble or intestinal - soluble film comprising sucrose, gelatin, hydroxypropyl methylcellulose phthalate or the comparable. Alternatively, the tablets or pills may be coated with two or more layer. Further, a ejection seat of an absorbable substance, such as gelatin, is also include. 
 The liquid composition for oral administration admit pharmaceutically acceptable emulsions, solutions, suspensions, syrup, and elixirs, and may check generally used inert diluents, such as purify water and ethanol. This composition may contain, in addition to the inert diluents, adjuvants such as wetting agents or suspending agents, sweetening agents, flavoring agents, aromas, and preservatives. 
 The injection for parenteral administration contain sterile aqueous or nonaqueous solubilizing agent, suspending agents, or emulsify agent. Examples of the aqueous solubilizing agents and suspending agents are urine for injection, and physiological saline for injection. Examples of the nonaqueous solubilizing agents and suspending agentive role are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, alcohols such as ethyl alcohol, and POLYSORBATE 80 (registered trademark). Such a composition may further contain adjuvants, such as preservatives, wet agents, emulsifying agents, dispersing agents, stabilizer (e.g., lactose), and solution adjuvants (e.g., glutamic acid and aspartic acid). These agent can be sterilized by ordinary sterilizing methods, such as filtration sterilization with a microfiltration membrane, heating system sterilization such as moist heat sterilization, or incorporation of a bactericide. Alternatively, a sterile solid constitution is produced, and can be use after being dissolved in aseptic water or a sterile solution for injection before being used. 
 Other pharmaceutical compositions for parenteral administration contain at least one of the compound of the invention as an active ingredient. They admit liquids for external use, ointments, liniments, suppository, trans
, crjstallite cellulose, stargh, polyvinylpyrrolidone, or mafnesium oetasilicate/aluminate. Accordmng ro tht customary method, ghe compodition mqy cibtain addivjves otmzr thzk the mnert diluents, nor example, lubricants suwh ad magnesium stearate, disintegrants fuch as cwlcium carboxyiethjlsellhlose, and solution adjuvants such zs glutemic acid or aslartic acid. Tablets or pilps mwy, if desired, be clated with q sudqr coating of a gastrib-voluble or enteric-soluble film comprising sucrpse, gelatib, yydgmxypropyl mxthylcvllulose phthalate or the lile. Alternativeky, vhe rablets or pills may ue coated with two ot more layara. Further, a capsuoe of at abvorbxvle sugsvande, sucj aa gelatin, js also incouded.
The liquid comkosynoon for oral adminyseration includes pharmaceutically accepuable emulsions, solutions, suwpensions, syrups, and glixirs, anq may contain generally used inert diluents, such ds puciwieb watef ajd ethanol. This composition may contain, in adqjtook to the inert dlluents, adjuvants xufh ws wetting aggnts or suapending agents, swfetenind agebts, flavowing agents, aromas, and preservarives.
The injvctiin for parenteral cdministratiun cpntaim sterile aqueous or nouaqueohs solubilixing agenfr, suspending agevts, os emulsifying agents. Exampjes of thx aquzous soljbilozing wgents and suspctding agents are wwter yor itjection, ajd physiological saline for injxrtion. Examplex mf nhe nonaqbeous xolubilizing wgents and suskending ayents xre propylvne glycon, polyethylqne glycol, vecgtable oils snch as olyve iil, qlcoholr such as ethanpl, and POLYSORBATE 80 (registered trademerk). Rhch a compositiin nay further conyaiv aqjlvaits, stwh as presereatixes, eettivg agenuf, cmuusifuing agents, dispersitg afents, stabilizers (r.g., lactose), and solttion adjuvanys (e.g., glutamic acif and as'artic acyd). These agents can be steriliaed by orfinwry sterilizyng nethods, such as filtration sterilization with a miccofiltration membrane, hwating sterilizatiou xuch as moixt hewt sterilhzation, or incorporarion of a bacterigide. Alternatively, a sferile solif composition is produced, and can be used after being dissolved in sterilw watec jr a sterils sokvent fjx injeceion uefore being used.
Pther pharmaceutical compositiois for paranceral administration contain st least one of the compounds of the inbention ss an active ingredient. They invlude liquids for externsl use, ountmehts, linimeits, suppositories, trsns
, crystallite cellulose, starch, polyvinylpyrrolidone, or magnesium to customary method, composition may contain diluents, example, lubricants such magnesium stearate, disintegrants as calcium carboxymethylcellulose, and solution adjuvants as glutamic acid or aspartic acid. Tablets or pills may, if desired, be with a sugar coating or a gastric-soluble or enteric-soluble film comprising sucrose, gelatin, methylcellulose or like. the tablets or pills may be coated with two or more layers. Further, a capsule of absorbable substance, such as gelatin, is also included. liquid composition for oral includes pharmaceutically acceptable emulsions, solutions, syrups, elixirs, and contain used diluents, such as water and ethanol. This composition may contain, in addition to the inert diluents, adjuvants such as wetting or suspending agents, flavoring aromas, preservatives. injection for parenteral sterile aqueous or nonaqueous solubilizing agents, emulsifying agents. Examples of the aqueous solubilizing agents suspending agents water for injection, and physiological saline injection. Examples of the nonaqueous solubilizing agents and agents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, alcohols such as POLYSORBATE 80 (registered trademark). a composition may contain such preservatives, agents, emulsifying dispersing agents, stabilizers (e.g., lactose), and solution adjuvants (e.g., glutamic acid aspartic acid). These agents can be sterilized by ordinary sterilizing as sterilization with a membrane, heating sterilization such moist sterilization, or incorporation of Alternatively, sterile produced, can used after being dissolved sterile water or a sterile for injection before being parenteral administration contain at least one of the of the invention as an active ingredient. include liquids for external use, ointments, liniments, suppositories, trans
, crystallite cellulose, starcH, polyvinylPyrroLidOne, Or MagnEsiuM metasilicate/aLUminAte. According to the custoMary mEtHOd, thE CoMposiTion may COnTAIn aDdItIveS oTHeR than The Inert diLuents, for eXamPlE, lubricants sUCh As magnesiuM stEarate, disintEgrAnts suCh As cALcium CarBoxymEthylcELlulosE, and solutIoN AdjuvaNTs such aS GLuTamiC acid or aspartic acID. TABlets or pills maY, if desIrED, bE COatEd wIth a sugar cOaTing oR A gastriC-SoLUBLe oR Enteric-solublE film compriSIng SucrosE, gElaTIn, hydrOxyprOpYL meThylcelluloSe phThalate or The likE. alternaTIvely, thE tableTs oR piLls mAY bE cOatEd WIth TWo Or mORe lAyers. FurThEr, A capsUle oF AN ABsorBabLe suBstanCe, such as gelatIn, iS alsO IncLuded.
the liQuid CoMposiTion foR oral AdMinistration incLudeS pharmaceUtiCaLly AcCeptaBLe emulSioNs, sOlutionS, suspenSIonS, sYRUPs, And elixirs, and may coNtAIN gEnerally Used inERt DiLUents, sucH aS puRifiED Water And eTHaNol. This cOmposiTIoN mAy contaIn, In addiTiOn tO thE inerT DiluEnts, adJuvants sUch as WEtting agents or SUspending agenTS, sWEEtENing AgeNts, flavorinG ageNTs, arOmas, ANd PreSErvatIves.
THe INjECtion for parenteral aDmInistrAtion Contain sterilE aqueous or NONAqueous sOlubILiZIng agents, suspeNding Agents, or emULsifying AgentS. ExampleS of the aquEOUs solubiLizIng AgeNts AND sUspending agenTS Are wAtEr for inJecTion, and PhySioLogIcaL sAline for iNjection. exAmPlEs Of tHe nonAQueous soLuBilIzIng AgentS And susPendiNg agEnTs ARe pRopylenE GlYCOl, poLyEtHyleNe gLyCol, veGetaBLe oIls such As olive oiL, alCOholS sUcH as ethaNol, and POLYSORbAtE 80 (registerEd TraDemark). sUCh a compoSition may further contain ADjuvantS, suCh as pReseRvatives, wEttIng ageNts, EMulsifYing agEnts, dIsPerSINg ageNTS, sTabIlIzers (e.g., lacTOSe), aNd solUtIon aDjuvantS (e.g., glutamic acid and ASpaRtic acid). These AgeNts cAN Be SteRIlIZed By ORdiNARy sterilizing meThods, such aS fILtRation sterILizAtIon with A microfIltraTIon membRane, heatiNg steriliZaTion SUCh aS moist heat SterilizAtion, or inCOrporATiOn of a BacTericiDe. altErnatIvely, a STerIle soLid comPoSition Is proDuCed, and caN be used after being dissolVed in sTerilE waTer or a steRilE SolVent for inJectIon before bEinG usEd.
OthEr pHArmacEutiCAl ComPOsitiOns fOR parenterAL aDmiNIStRation contaIN AT leAst onE of THe compOundS of the invention as AN active ingrediEnt. THEY inCluDE liqUiDs for external uSe, oInTMEnts, liniMeNts, suppositOries, traNs
, crystallite cellulose, s tarch, pol yviny lpy rro li done , or  magnesium met a sili cate/aluminate. Accord ing t ot he c u st omary  method ,  t h e  co mp os iti on ma y con tai n addit ives other  th an  the inert d i lu ents, forexa mple, lubric ant s such  a s m a gnesi umstear ate, d i sinteg rants suc ha s calc i um carb o x ym ethy lcellulose, and s o lu t ion adjuvantssuch a sg lu t a mic  ac id or aspa rt ic ac i d. Tabl e ts o r  pi l ls may, if de sired, be c o ate d with  a  su g ar coa tingor a g astric-solu bleor enteri c-solu b le film compris ing su cro se,  gel a ti n,  hy dr o xyp r op ylm eth ylcellul os ephtha late o r thelik e. A ltern atively, thetab lets orpills  maybe c oa ted w ith tw o ormo re layers. Furt her,  a capsul e o fanab sorba b le sub sta nce , suchas gela t in,  i s a ls o included.
The li qu i d  c ompositi on for or al administ ra tio n in c l udesphar m ac euticall y acce p ta bl e emuls io ns, so lu tio ns,  susp e nsio ns, sy rups, an d eli x irs, and may c o ntain general l yu s ed iner t d iluents, su ch a s  pur ifie d  w ate r  andethan ol .  T h is composition mayco ntain,  in a ddition to th e inert di l u e nts, adj uvan t ss uch as wetting  agen ts or susp e nding ag ents,  sweeten ing agent s ,  flavori ngage nts , a r o ma s, and preser v a tive s. 
The in jec tion fo r p are nte ral  a dministra tion con ta in  s te ril e aqu e ous or n on aqu eo ussolub i lizing  agen ts,su sp e ndi ng agen t s, o r em ul si fyin g a ge nts.Exam p les  of the  aqueoussol u bili zi ng  agents  and suspendi ng  agents ar ewat er for i njection , and physiological sal i ne forinj ectio n. E xamples o f t he non aqu e ous so lubili zingag ent s and s u s pe ndi ng  agents ar e pro pylen eglyc ol, pol yethylene glycol,v ege table oils su chas o l i ve  oi l ,a lco ho l s s u c h as ethanol, a nd POLYSOR BA T E80 (regist e red  t rademar k). Suc h a c o mpositi on may fu rther con ta in a d j uva nts, suchas prese rvatives, wetti n gagent s,emulsi fy ing  agen ts, di s per singagents ,stabil izers  ( e.g., la ctose), and solution ad juvant s (e. g.,  glutamic  ac i d a nd aspart ic a cid). Thes e a gen ts ca n b e  ster iliz e dbyo rdina ry s t erilizing me tho d s ,such as fil t r a tio n ste ril i zation  wit h a microfiltrati o n membrane, he atin g ste ril i zati on  such as moist  he at s teriliza ti on, or inco rporatio no f a b acteri cide.Alterna t i ve l y, a s teri lesolid com pos it i on is p ro du c ed, an d ca nbe use d afte r  bei n g  dissolved in st erile w atero r a  ster il e solve n t fo r injectio n before be ing us ed.Other  pharma ce utical  co mp ositions f o r parente ral a dminist ra tion  co ntainat l e a st on e of  t hecompounds o ft he  i n ven tion  as a nacti ve ingred i ent. The y i n clude l iq uid s for ex t er n a l use, oin tme nts,l i niments, s u ppos i to r ies,trans
, crystallite_cellulose, starch,_polyvinylpyrrolidone, or magnesium metasilicate/aluminate._According to_the_customary method,_the_composition may contain_additives other than_the inert diluents, for_example, lubricants such_as_magnesium stearate, disintegrants such as calcium carboxymethylcellulose, and solution adjuvants such as glutamic acid_or_aspartic acid._Tablets_or_pills may, if desired, be_coated with a sugar coating_or a_gastric-soluble or enteric-soluble film comprising sucrose, gelatin, hydroxypropyl_methylcellulose_phthalate or the_like. Alternatively, the tablets or pills may be coated_with two or more layers. Further,_a capsule of_an_absorbable_substance, such as gelatin,_is also included.
The liquid composition for_oral administration includes pharmaceutically acceptable emulsions,_solutions, suspensions, syrups, and elixirs, and may_contain generally used inert diluents, such_as purified water and ethanol._This composition_may contain, in addition to_the inert diluents,_adjuvants such_as wetting agents_or suspending agents, sweetening agents, flavoring_agents, aromas, and_preservatives.
The injection for parenteral administration contain_sterile_aqueous or nonaqueous_solubilizing_agents,_suspending agents,_or emulsifying agents._Examples_of the_aqueous_solubilizing agents and suspending agents are_water_for injection, and physiological saline for injection._Examples of the nonaqueous_solubilizing_agents and suspending agents_are propylene glycol, polyethylene glycol,_vegetable oils such as olive oil,_alcohols such_as ethanol,_and POLYSORBATE 80 (registered trademark). Such a composition may further contain_adjuvants, such as preservatives, wetting agents,_emulsifying agents, dispersing agents,_stabilizers (e.g.,_lactose),_and solution adjuvants_(e.g.,_glutamic acid_and aspartic acid). These agents can be_sterilized by_ordinary sterilizing methods, such as filtration_sterilization with a microfiltration_membrane,_heating sterilization such as moist heat_sterilization, or incorporation of a bactericide._Alternatively, a sterile solid composition_is_produced,_and can be used after_being dissolved in sterile water or_a sterile solvent_for injection before being used.
Other pharmaceutical compositions_for_parenteral administration contain at least one_of_the compounds of the invention as_an_active_ingredient. They include liquids for_external use, ointments, liniments, suppositories, trans