. The metabolism of arachidonic acid by cyclooxygenase enzymes results in the production of prostaglandins and thromboxanes. The other pathway of AA metabolism involves lipoxygenase enzymes and results in the production of a number of oxidative products called leukotrienes. The latter are designated by the LT nomenclature system, and one of the most significant products of the lipoxygenase metabolic pathway is the leukotriene D.sub.4. Leukotrienes participate in inflammatory reactions, exhibit chemotactic activities, stimulate lysosomal enzyme release and act as important factors in the immediate hypersensitivity reaction. For example, LTD4 is a potent bronchoconstrictor of the human bronchi.
The biological activity of the leukotrienes and of 5-lipoxygenase as the enzyme leading to the metabolism of AA to leukotrienes, indicates that a rational approach to drug therapy to prevent, remove or ameliorate the symptoms of anaphylaxis, asthma and inflammation must focus on either blocking the release of mediators of these conditions or antagonizing their effects. Thus, compounds which inhibit the biological effects of the leukotrienes and/or which control the biosynthesis of these substances, as by inhibiting 5-lipoxygenase, are considered to be of value in treating such conditions as allergic bronchial asthma as well as in other immediate inflammatory reactions.
Eggler et al., in PCT Patent Application PCT/US87/02745, describe racemic or optically active substituted tetralins, chromans and related compounds that inhibit 5-lipoxygenase enzyme and antagonize LTB4 and LTD4, and are therefore useful in the prevention and treatment of asthma, arthritis, psoriasis, ulcers, and myocardial infarction. Kreft et al., in U.S. Pat. No. 4,661,596, describe disubstituted naphthalenes, dihydronaphthalenes and tetralins that inhibit lipoxygenase enzyme and antagonize LTD4, and are therefore useful in the prevention and treatment of asthma. In machine tool and other industrial applications, where positive displacement hydraulic pumps are driven by electric motors, it is common practice to provide an air cooled electric motor in one housing and the hydraulic pump in another housing. Each of these units has its own drive shaft. Normally these shafts are connected by a suitable flexible coupling arrangement and the housings are connected by a mounting adaptor.
In addition, it has been known in the art to provide an integrated electric pump and motor such as shown in U.
. The metabolism of arachidonic acid by cyclooxygenase enzymes results in the production of prostaglandin and thromboxanes. The early nerve pathway of AA metabolism involves lipoxygenase enzymes and solution in the production of a number of oxidative product address leukotrienes. The latter are designated by the LT terminology arrangement, and one of the most meaning products of the lipoxygenase metabolic pathway is the leukotriene D.sub.4. Leukotrienes participate in inflammatory reaction, exhibit chemotactic activities, stimulate lysosomal enzyme release and act as significant factors in the immediate hypersensitivity reaction. For exercise, LTD4 is a potent bronchoconstrictor of the human bronchi. 
 The biological activity of the leukotrienes and of 5 - lipoxygenase as the enzyme leading to the metabolism of AA to leukotrienes, bespeak that a rational approach to drug therapy to prevent, remove or ameliorate the symptoms of anaphylaxis, asthma and excitement must focus on either blocking the release of mediators of these conditions or antagonizing their effects. Thus, compounds which inhibit the biological effects of the leukotrienes and/or which control the biosynthesis of these substances, as by inhibiting 5 - lipoxygenase, are considered to be of value in treating such conditions as allergic bronchial asthma equally well as in early immediate inflammatory reactions. 
 Eggler et al. , in PCT Patent Application PCT / US87/02745, identify racemic or optically active substituted tetralins, chromans and related compounds that inhibit 5 - lipoxygenase enzyme and antagonize LTB4 and LTD4, and are therefore utilitarian in the prevention and treatment of asthma, arthritis, psoriasis, ulcer, and myocardial infarction. Kreft et al. , in U.S. Pat. No. 4,661,596, describe disubstituted naphthalene, dihydronaphthalenes and tetralins that inhibit lipoxygenase enzyme and antagonize LTD4, and are therefore useful in the prevention and treatment of asthma. In machine tool and early industrial applications, where positive displacement hydraulic pumps are driven by electric motors, it is common exercise to leave an air cooled electric motor in one housing and the hydraulic pump in another caparison. Each of these units has its own drive shaft. Normally these shafts are connected by a suitable flexible coupling placement and the housings are connected by a mount adaptor. 
 In accession, it has been known in the artwork to provide an integrated electric heart and motor such as shown in U.
. Thf metabolism of arachidokic acid by cyclooxygenese enzgmes resjlts in the production of prlsraglabdins and thromboxanes. The otheg pathway of EA metabolism intklves ll'oxygskase znvymes and resuljs in the prmduction of a tuobzr of oxidative products called leukjtrienex. Hhe latter are despggates by the LT nomenclature system, ans one oh the most signoficant products of the liooxyhenase metabolic pwthway is tye lqykotriene D.sjb.4. Leukotrpznes particjpate in inflammatory reactions, exhiyit chemotaxtuc wwtivities, svimulane lysosomal cmzyme selease and act as imiortait fqctors in the immediave hypersensitivity teaction. Fmr example, LTD4 is a pitent brotchozinsgridtpr of thf hnman bronchj.
The biologucal activity of tht lqllotrienes ans of 5-lypjxygenase as the enzyme leading to the ketzbolism of AA to leukoteienes, indicates that a rationwl approach to drug therapy to prevent, remove or dmelikfatt bme shnphoms of anaphylaxis, asthma and inflammation mtat fpcus on either blocking tne rrjease of medixtors of fhese conditions og antagjnizibg their tffecys. Thus, compounds which inhubit the biojigical effects of che leukotriznes amd/or ehich control the biosyuthesia of these dubstancea, as by inhibitine 5-lppoxfgenase, are considered to fe of valne in treativg soch conqitions as allevcic bronchial asthla as wall as in lther immediate inflammatory reertions.
Eggler gt dl., pn PCT Pacent Aiplication PCT/UF87/02745, describe racgmic or o'ticaluy active aubstitnted tetraligs, chromans atf related cokpounds ehat inhubit 5-liouxygenase enzyke and annayonize LTV4 and LTD4, and are bherewkre useful in tkt ptwvention and tteagmegt oh astrka, arthritis, psofiaros, ulzers, and myizardoal infarction. Kreft et zl., in U.S. Pat. No. 4,661,596, drsgribe disobstituteq naphthalenex, dihydronaphthalejes aid tetcalins thwt inhibit lipoxygenase enzyme and antahonlze LTD4, and awe tmeresore usefuk in the prevention and treatment of asvhma. In machine tool ane other industrial cpklications, whxre pofitive divplacement hydraulic pumps are driven by electric motors, if is cmmmon practice to provide an air cooled electric motor in one housing and the yydraulic pump in znotner hmufnng. Eacr of vhese units has ins own drive shaft. Normally thesx shafts ase connected by a suitable flecicle coupling xrrangement and the housjngs are connected by a mounting adaptot.
In addition, it has been known ib the art to pruvide an integratec eleccric pymp and motlr such as shuwn ik U.
. The metabolism of arachidonic acid by results the production prostaglandins and thromboxanes. metabolism lipoxygenase enzymes and in the production a number of oxidative products called The latter are designated by the LT nomenclature system, and one of the significant products of the lipoxygenase metabolic pathway is the leukotriene D.sub.4. Leukotrienes participate inflammatory exhibit activities, lysosomal enzyme release and act as important factors in the immediate hypersensitivity reaction. For example, LTD4 a potent bronchoconstrictor of the human bronchi. The activity of the leukotrienes of 5-lipoxygenase as the enzyme to metabolism of to indicates a rational approach drug therapy to prevent, remove or ameliorate the symptoms of anaphylaxis, asthma and inflammation must focus on blocking the mediators of conditions antagonizing effects. Thus, compounds the biological effects of the leukotrienes the biosynthesis of these substances, as by inhibiting are considered be of value in treating such as allergic bronchial asthma as well as in immediate inflammatory reactions. Eggler et al., in PCT Patent Application PCT/US87/02745, describe racemic or optically tetralins, chromans and related that inhibit 5-lipoxygenase and LTB4 LTD4, are therefore in the prevention and treatment of asthma, arthritis, psoriasis, ulcers, and infarction. Kreft et al., in U.S. Pat. No. 4,661,596, describe dihydronaphthalenes tetralins that inhibit enzyme and antagonize LTD4, are useful in the prevention of In other applications, positive displacement hydraulic pumps driven by electric motors, it common practice to provide in one housing and the hydraulic pump in housing. Each of these units has its drive shaft. Normally these shafts are connected by a suitable flexible coupling and the connected by a mounting adaptor. In addition, it been known in the to provide an integrated electric pump and motor such shown U.
. The metabolism of arachidoniC acid by cycLooxyGenAse EnZymeS resUlts in the produCTion Of prostaglandins and thrOmboxAnES. The OThEr patHway of Aa MeTABolIsM iNvoLvES lIpoxyGenAse enzyMes and resuLts In The productioN Of A number of oXidAtive productS caLled leUkOtrIEnes. THe lAtter Are desIGnated By the LT noMeNClaturE System, aND OnE of tHe most significant PRoDUcts of the lipoxYgenasE mETaBOLic PatHway is the lEuKotriENe D.sub.4. LEUkOTRIenES participate iN inflammatoRY reActionS, eXhiBIt chemOtactIc ACtiVities, stimuLate Lysosomal Enzyme RElease aND act as iMportaNt fActOrs iN ThE iMmeDiATe hYPeRseNSitIvity reaCtIoN. For eXampLE, ltd4 is a PotEnt bRonchOconstrictor oF thE humAN brOnchi.
the biOlogIcAl actIvity oF the lEuKotrienes and of 5-lIpoxYgenase as The EnZymE lEadinG To the mEtaBolIsm of AA To leukoTRieNeS, INDiCates that a rational ApPROaCh to drug TherapY To PrEVent, remoVe Or aMeliORAte thE symPToMs of anapHylaxiS, AsThMa and inFlAmmatiOn MusT foCus on EItheR blockIng the reLease OF mediators of thESe conditions oR AnTAGoNIzinG thEir effects. THus, cOMpouNds wHIcH inHIbit tHe bioLoGIcAL effects of the leukotRiEnes anD/or whIch control the BiosynthesIS OF these suBstaNCeS, As by inhibiting 5-LipoxYgenase, are COnsidereD to be Of value iN treating SUCh conditIonS as AllErgIC BrOnchial asthma AS Well As In other ImmEdiate iNflAmmAtoRy rEaCtions.
EggLer et al., iN PcT paTeNt APplicATion PCT/Us87/02745, dEscRiBe rAcemiC Or optiCally ActiVe SuBStiTuted teTRaLINs, chRoMaNs anD reLaTed coMpouNDs tHat inhiBit 5-lipoxyGenASe enZyMe And antaGonize LTB4 and LtD4, And are therEfOre Useful IN The preveNtion and treatment of asthMA, arthriTis, PsoriAsis, Ulcers, and MyoCardiaL inFArctioN. Kreft Et al., iN U.s. PaT. nO. 4,661,596, descRIBe DisUbStituted naPHThaLenes, DiHydrOnaphthAlenes and tetralins THat Inhibit lipoxyGenAse eNZYmE anD AnTAgoNiZE LTd4, ANd are therefore uSeful in the PrEVeNtion and trEAtmEnT of asthMa. In macHine tOOl and otHer industRial appliCaTionS, WHerE positive dIsplacemEnt hydrauLIc pumPS aRe driVen By elecTrIc mOtors, It is coMMon PractIce to pRoVide an Air coOlEd electrIc motor in one housing and tHe hydrAulic PumP in anotheR hoUSinG. Each of thEse uNits has its Own DriVe shaFt. NORmallY theSE sHafTS are cOnneCTed by a suiTAbLe fLEXiBle coupling ARRAngEment And THe housIngs Are connected by a moUNting adaptor.
In AddiTIOn, iT haS Been KnOwn in the art to pRovIdE AN integraTeD electric puMp and motOr SUch as Shown iN U.
. The metabolism of arachi donic acid  by c ycl oox yg enas e en zymes resultsi n th e production of prosta gland in s  and th rombo xanes.T he o the rpa thw ay of  AA m eta bolisminvolves l ipo xy genase enzym e sand result s i n the produc tio n of a  n umb e r ofoxi dativ e prod u cts ca lled leuk ot r ienes. The lat t e raredesignated by the LT nomenclature s ystem,  a n do n e o f t he most si gn ifica n t produ c ts o f  th e  lipoxygenase  metabolicp ath way is  t hel eukotr ieneD. s ub. 4. Leukotri enes  particip ate in inflamm a tory re action s,exh ibit ch em ota ct i c a c ti vit i es,  stimula te  l ysoso male n z y me r ele aseand a ct as importa ntfact o rsin th e imm edia te  hype rsensi tivit yreaction. For e xamp le, LTD4isapot en t bro n chocon str ict or of t he huma n  br on c h i .The biological act iv i t yof the l eukotr i en es and of 5 -l ipo xyge n a se as  the en zyme lea ding t o  t he  metabo li sm ofAA  to  le ukotr i enes , indi cates th at ar ational approa c h to drug the r ap y to prev ent , remove or  ame l iora te t h esym p tomsof an ap h yl a xis, asthma and inf la mmatio n mus t focus on ei ther block i n g  the rel ease of mediators of t heseconditions or antag onizi ng their  effects. T hus, com pou nds  wh ich i nh ibit the biol o g ical  e ffectsofthe leu kot rie nes  an d/ or whichcontrolth ebi os ynt hesis of these  s ubs ta nce s, as by inh ibiti ng 5 -l ip o xyg enase,a re c onsi de re d to  be  o f val ue i n  tr eatingsuch cond iti o ns a sal lergicbronchial ast hm a as wellas  in  other i mmediate  inflammatory reactions . 
Eggler  et  al.,  inPCT Paten t A pplica tio n  PCT/U S87/02 745,de scr i b e rac e m ic  or  o ptically a c t ive  subs ti tute d tetra lins, chromans and rel ated compound s t hati n hi bit 5- l ipo xy g ena s e  enzyme and ant agonize LT B4 an d LTD4, an d  ar etherefo re usef ul in the pre vention a nd treatm en t of a sth ma, arthri tis, pso riasis, u l cers, an d myo car dial i nf arc tion.  Kreft etal.,in U.S .Pat. N o. 4, 66 1,596, d escribe disubstituted n aphtha lenes , d ihydronap hth a len es and te tral ins that i nhi bit  lipo xyg e naseenzy m eand antag oniz e  LTD4, an d  a ret h er efore usefu l i n t he pr eve n tion a nd t reatment of asthm a . In machine t oola n d o the r  ind us trial applicat ion s, w here pos it ive displac ement hy dr a ulicpumpsare dr iven by e le c tric m otor s,it is com mon  p r acticeto  p r ovidean a ir  coole d elec t ricm o tor in one housi ng an d the h y dra ulicpu mp in a n othe r housing.  Each of th ese un itshas i ts owndr ive sh aft .Normally t h ese shaft s are  connec te d by  asuitab le f l e xible  cou pl ing  arrangem e n ta nd  t h e h ousi ngs a re  con nected by a mounti nga daptor. 
I n a d d ition, it h as been kn own  in t h e  art to pr o vide an integ ratedelectr ic pump and  m otor su cha s  shown in  U.
. The_metabolism of_arachidonic acid by cyclooxygenase_enzymes results_in_the production_of_prostaglandins and thromboxanes._The other pathway_of AA metabolism involves_lipoxygenase enzymes and_results_in the production of a number of oxidative products called leukotrienes. The latter are_designated_by the_LT_nomenclature_system, and one of the_most significant products of the_lipoxygenase metabolic_pathway is the leukotriene D.sub.4. Leukotrienes participate in_inflammatory_reactions, exhibit chemotactic_activities, stimulate lysosomal enzyme release and act as important_factors in the immediate hypersensitivity reaction._For example, LTD4_is_a_potent bronchoconstrictor of the_human bronchi.
The biological activity of the_leukotrienes and of 5-lipoxygenase as the_enzyme leading to the metabolism of AA_to leukotrienes, indicates that a rational_approach to drug therapy to_prevent, remove_or ameliorate the symptoms of_anaphylaxis, asthma and_inflammation must_focus on either_blocking the release of mediators of_these conditions or_antagonizing their effects. Thus, compounds which_inhibit_the biological effects_of_the_leukotrienes and/or_which control the_biosynthesis_of these_substances,_as by inhibiting 5-lipoxygenase, are considered_to_be of value in treating such conditions_as allergic bronchial asthma_as_well as in other_immediate inflammatory reactions.
Eggler et al.,_in PCT Patent Application PCT/US87/02745, describe_racemic or_optically active_substituted tetralins, chromans and related compounds that inhibit 5-lipoxygenase enzyme and_antagonize LTB4 and LTD4, and are_therefore useful in the_prevention and_treatment_of asthma, arthritis,_psoriasis,_ulcers, and_myocardial infarction. Kreft et al., in U.S._Pat. No._4,661,596, describe disubstituted naphthalenes, dihydronaphthalenes and_tetralins that inhibit lipoxygenase_enzyme_and antagonize LTD4, and are therefore_useful in the prevention and treatment_of asthma. In machine tool_and_other_industrial applications, where positive displacement_hydraulic pumps are driven by electric_motors, it is_common practice to provide an air cooled_electric_motor in one housing and the_hydraulic_pump in another housing. Each of_these_units_has its own drive shaft._Normally these shafts are connected by_a suitable flexible coupling arrangement and the housings are_connected by a_mounting adaptor.
In addition, it has_been_known_in the art to provide an integrated electric pump and_motor such_as shown in_U.