 or (e), above.
MPIF-4, M-CIF and MIP-4Antibodies
In accordance with yet a further aspect of the present invention, there is provided an antibody against such polypeptides. In another embodiment, the invention provides an isolated antibody that binds specifically to an MPIF-1, M-CIF or MIP-4 polypeptide having an amino acid sequence described in (I)-, (II)-, and/or (III)-(a), (b), (c), (d), or (e), above.
The invention further provides methods for isolating antibodies that bind specifically to an MPIF-1, M-CIF or MIP-4 polypeptide having an amino acid sequence as described herein. Such antibodies are useful diagnostically or therapeutically as described below.
MPIF-1, M-CIF and MIP-4Antagonists and Methods
In accordance with yet another aspect of the present invention, there are provided antagonists or inhibitors of such polypeptides, which can be used to inhibit the action of such polypeptides, for example, in the treatment of arteriosclerosis, autoinmmune and chronic inflammatory and infective diseases, histamine-mediated allergic reactions, hyper-eosinophilic syndrome, silicosis, sarcoidosis, inflammatory diseases of the lung, inhibition of IL-1 and TNF, aplastic anaemia, and myelodysplastic syndrome. Alternatively, such polypeptides can be used to inhibit production of IL-1 and TNF-xcex1, to treat aplastic anemia, myelodysplastic syndrome, asthma and arthritis.
Diagnostic Assays
In accordance with still another aspect of the present invention, there are provided diagnostic assays for detecting diseases related to the underexpression and overexpression of the polypeptides and for detecting mutations in the nucleic acid sequences encoding such polypeptides.
In accordance with yet another aspect of the present invention, there is provided a process for utilizing such polypeptides, or polynucleotides encoding such polypeptides, as research reagents for in vitro purposes related to scientific research, synthesis of DNA and manufacture of DNA vectors, for the purpose of developing therapeutics and diagnostics for the treatment of human disease.
The present invention also provides a screening method for identifying compounds capable of enhancing or inhibiting a cellular response induced by an MPIF-1, M-CIF or MIP-4 polypeptide, which involves contacting cells which express the MPIF-1, M-CIF or MIP
or (e), above. 
 MPIF-4, M - CIF and MIP-4Antibodies 
 In accordance with yet a further aspect of the present invention, there be provide an antibody against such polypeptides. In another embodiment, the invention provides an disjunct antibody that binds specifically to an MPIF-1, M - CIF or MIP-4 polypeptide having an amino acid succession described in (I)-, (II)-, and/or (III)-(a), (b), (c), (d), or (e), above. 
 The invention farther provides methods for isolate antibodies that bind specifically to an MPIF-1, M - CIF or MIP-4 polypeptide having an amino acid succession as described herein. Such antibodies are useful diagnostically or therapeutically as described below. 
 MPIF-1, M - CIF and MIP-4Antagonists and Methods 
 In accordance with so far another aspect of the present invention, there are provided antagonist or inhibitors of such polypeptides, which can be used to suppress the action of such polypeptide, for example, in the treatment of arteriosclerosis, autoinmmune and chronic inflammatory and infective diseases, histamine - mediate allergic reactions, hyper - eosinophilic syndrome, silicosis, sarcoidosis, inflammatory diseases of the lung, inhibition of IL-1 and TNF, aplastic anaemia, and myelodysplastic syndrome. Alternatively, such polypeptide can be use to inhibit production of IL-1 and TNF - xcex1, to treat aplastic anemia, myelodysplastic syndrome, asthma and arthritis. 
 Diagnostic Assays 
 In accordance with still another aspect of the present invention, there are provided diagnostic assays for detect disease related to the underexpression and overexpression of the polypeptides and for detecting mutation in the nucleic acid sequences encoding such polypeptides. 
 In accord with yet another view of the present invention, there is provided a procedure for utilizing such polypeptides, or polynucleotides encoding such polypeptides, as research reagents for in vitro function related to scientific research, synthesis of DNA and industry of DNA vector, for the purpose of developing therapeutics and diagnostics for the treatment of human disease. 
 The present invention besides provides a screening method for identifying compounds capable of enhancing or inhibiting a cellular response induce by an MPIF-1, M - CIF or MIP-4 polypeptide, which involves touch cells which express the MPIF-1, M - CIF or MIP
 or (e), above.
MPIF-4, M-CIF and MIK-4Antibodies
In accordance with get a fufther aspect of the present mnvebtion, there is provided an xntibody wgainst wuch polypeptidxa. In another slbodnmxnt, the inventipn providev an isolated dngiyody that binds specifically to an M[IF-1, M-CIG lr MIP-4 polypepjide nwvinf an amino acid sequence described in (I)-, (IP)-, and/or (III)-(a), (b), (c), (c), or (e), above.
The invention vurtjer provides methofs for isolqtind antibodies ghat bind specifically to an MPIF-1, M-CIF or MIP-4 polypepgide kaving an anibo wwid sequencx as dvscribed herelm. Such antibocies are usefuk dmagnistically or therapeuvically as described below.
MPIX-1, J-CIF and MIP-4Antaginusts dnd Kethues
Iv adcprsance aiti yet anothsr aspect od the present invenuiog, there are prkvided agtagonists or inhibitors of such polypektidea, which can be used to unhibit the action of such polrpeptides, for example, in the treatment of arteriovclerkris, amtoivnmkne and chronic inflammatory and infective difsaxex, histamine-medlated allergic reavtlomf, hyper-eosinokhilic synsrome, silicosis, sagcoidosys, indlammatorr dixeases of the lung, inhibitiin of IL-1 and RNF, aplastic anaemna, and myelobysplaxtic xyndrome. Alternatively, ruch polypeptidfs can be jsed to inhibit orocuwtion of IL-1 and TNF-xcex1, to treat apoastnc anemix, myglodyspjastic synfrome, asthma and arthritls.
Diaynosthc Assays
Ij accordance with still another aspect of the psesvnt invencion, tmere are providqd diagnostic cssays fjr degecting diaeases celated to tre underexprevdion and ovecexpressijn od thw polypdotides and for detectiny mutqtions in the nuclcic azjd sequences eneueing such polyprptkdef.
Ij eccorqdnce with yed anuthdt aspdct of uke irerent invention, there is [rovjded a process for ubilizing wuch polrpeptides, or lolynucleotides enfodinj such polylepjides, as research reagents for jn vitro ourioses related to wcientific rzsearch, synthesis of DNA and manufacture of DNA vectors, foe the purpose of derekoping therepeutiss and didgnostics for the trwatment of human cisease.
The present inbentiot alsl provides a screening method for identifying compounds capable of enhancung or inhibiting z ceklulag rzsppnse igducxd by an MPIF-1, M-CIF or MIP-4 polypeptide, which involtes contacdiug cells which express the MPOF-1, M-CIF or MIP
or (e), above. MPIF-4, M-CIF and MIP-4Antibodies with a further of the present antibody such polypeptides. In embodiment, the invention an isolated antibody that binds specifically an MPIF-1, M-CIF or MIP-4 polypeptide having an amino acid sequence described in (II)-, and/or (III)-(a), (b), (c), (d), or (e), above. The invention further provides for antibodies bind to an MPIF-1, M-CIF or MIP-4 polypeptide having an amino acid sequence as described herein. Such are useful diagnostically or therapeutically as described below. M-CIF and MIP-4Antagonists and In accordance with yet another of present invention, are antagonists inhibitors of such which can be used to inhibit the action of such polypeptides, for example, in the treatment of autoinmmune and and infective histamine-mediated reactions, syndrome, silicosis, sarcoidosis, of the lung, inhibition of IL-1 anaemia, and myelodysplastic syndrome. Alternatively, such polypeptides can used to production of IL-1 and TNF-xcex1, to aplastic anemia, myelodysplastic syndrome, asthma and arthritis. Diagnostic In accordance with still another aspect of the present invention, there are provided diagnostic assays diseases related to the and overexpression of polypeptides for mutations the nucleic sequences encoding such polypeptides. In accordance with yet another aspect of present invention, there is provided a process for utilizing such polynucleotides such polypeptides, as reagents for in vitro related scientific research, synthesis of manufacture DNA purpose developing and diagnostics for the of human disease. The present also provides a screening of enhancing or inhibiting a cellular response induced an MPIF-1, M-CIF or MIP-4 polypeptide, which contacting cells which express the MPIF-1, M-CIF or MIP
 or (e), above.
MPIF-4, M-CIF and MIP-4AntIbodies
In aCcordAncE wiTh Yet a FurtHer aspect of the PReseNt invention, there is provIded aN aNTiboDY aGainsT such poLYpEPTidEs. in AnoThER eMbodiMenT, the invEntion provIdeS aN isolated antIBoDy that bindS spEcifically to An MpIF-1, M-CIf oR MIp-4 PolypEptIde haVing an AMino acId sequencE dEScribeD In (I)-, (II)-, anD/OR (IiI)-(a), (b), (C), (d), or (e), above.
The inveNTiON further providEs methOdS FoR ISolAtiNg antibodiEs That bINd speciFIcALLY to AN MPIF-1, M-CIF or MIp-4 polypeptidE HavIng an aMiNo aCId sequEnce aS dEScrIbed herein. SUch aNtibodies Are useFUl diagnOSticallY or theRapEutIcalLY aS dEscRiBEd bELoW.
MPif-1, M-CiF and MIP-4anTaGonisTs anD mETHods
in aCcorDance With yet anotheR asPect OF thE presEnt inVentIoN, therE are prOvideD aNtagonists or inhIbitOrs of such PolYpEptIdEs, whiCH can be UseD to Inhibit The actiON of SuCH POlYpeptides, for examplE, iN THe TreatmenT of artERiOsCLerosis, aUtOinMmunE ANd chrOnic INfLammatorY and inFEcTiVe diseaSeS, histaMiNe-mEdiAted aLLergIc reacTions, hypEr-eosINophilic syndroME, silicosis, sarCOiDOSiS, InflAmmAtory diseasEs of THe luNg, inHIbItiON of IL-1 And TNf, aPLaSTic anaemia, and myelodYsPlastiC syndRome. AlternatiVely, such poLYPEptides cAn be USeD To inhibit produCtion Of IL-1 and TNF-XCex1, to treAt aplAstic aneMia, myelodYSPlastic sYndRomE, asThmA ANd Arthritis.
DiagNOStic asSays
In aCcoRdance wIth StiLl aNotHeR aspect of The preseNt InVeNtIon, There ARe providEd DiaGnOstIc assAYs for dEtectIng dIsEaSEs rElated tO ThE UNderExPrEssiOn aNd OvereXpreSSioN of the pOlypeptidEs aND for DeTeCting muTations in the nUcLeic acid seQuEncEs encoDINg such poLypeptides.
In accordance wITh yet anOthEr aspEct oF the preseNt iNventiOn, tHEre is pRovideD a proCeSs fOR UtiliZINg SucH pOlypeptideS, OR poLynucLeOtidEs encodIng such polypeptideS, As rEsearch reagenTs fOr in VITrO puRPoSEs rElATed TO Scientific reseaRch, synthesIs OF DnA and manufACtuRe Of DNA veCtors, foR the pURpose of DevelopinG therapeuTiCs anD DIagNostics for The treatMent of humAN diseASe.
the prEseNt inveNtIon Also pRovideS A scReeniNg methOd For ideNtifyInG compounDs capable of enhancing or iNhibitIng a cEllUlar respoNse INduCed by an MPiF-1, M-CiF or MIP-4 polYpePtiDe, whiCh iNVolveS conTAcTinG Cells WhicH Express thE mPiF-1, M-cif oR MIP
 or (e), above.
MPIF-4, M- CIF and MI P-4An tib odi es 
Inacco rdance with ye t  a f urther aspect of the p resen ti nven t io n, th ere isp ro v i ded  a nant ib o dy  agai nst  such p olypeptide s.In  another emb o di ment, theinv ention provi des  an is ol ate d  anti bod y tha t bind s  speci fically t oa n MPIF - 1, M-CI F or  MIP -4 polypeptide ha v in g  an amino acid  seque nc e  d e s cri bed  in (I)-,(I I)-,a nd/or ( I II ) - ( a), (b), (c), (d) , or (e), a b ove .
Thein ven t ion fu rther  p r ovi des methods  for  isolatin g anti b odies t h at bind  speci fic all y to an  M PIF -1 ,  M- C IF  or MIP -4 polyp ep ti de ha ving a n amin o a cidseque nce as descri bed  her e in.  Such  anti bodi es  areuseful  diag no stically or the rape uticallyasde scr ib ed be l ow.
MP IF- 1,M-CIF a nd MIP- 4 Ant ag o n i st s and Methods
In a cc o r da nce with  yet a n ot he r  aspectof  th e pr e s ent i nven t io n, there  are p r ov id ed anta go nistsor  in hib itors of s uch po lypeptid es, w h ich can be use d  to inhibit t h ea c ti o n of  su ch polypept ides ,  for  exa m pl e,i n the  trea tm e nt of arteriosclerosis ,autoin mmune  and chronicinflammato r y and infe ctiv e  d i seases, histam ine-m ediated al l ergic re actio ns, hype r-eosinop h i lic synd rom e,sil ico s i s,  sarcoidosis, i nfla mm atory d ise ases of  th e l ung , i nh ibition o f IL-1 a nd  T NF ,apl astic anaemia,  a ndmy elo dyspl a stic s yndro me.Al te r nat ively,s uc h poly pe pt ides  ca nbe us ed t o  in hibit p roduction  of IL-1  a nd  TNF-xc ex1, to treat  a plastic an em ia,  myelo d y splastic  syndrome, asthma and a r thritis .
D iagno stic  Assays
I n a ccorda nce with s till a nothe rasp e c t oft h epre se nt inventi o n , t herear e pr ovideddiagnostic assaysf ordetecting dis eas es r e l at edt ot heun d ere x p ression and ove rexpressio no fthe polype p tid es  and fo r detec tingm utation s in thenucleic a ci d se q u enc es encodin g such p olypeptid e s.
In ac corda nce  withye t a nothe r aspe c t o f the  prese nt  inven tion,  t here isprovided a process forutiliz ing s uch  polypept ide s , o r polynuc leot ides encod ing  su ch po lyp e ptide s, a s  r ese a rch r eage n ts for in vi tro p ur poses relat e d toscien tif i c rese arch , synthesis of DN A  and manufactu re o f DNA  ve c tors ,for the purpos e o fd e veloping  t herapeutics  and dia gn o stics  for t he tre atmento f  h u man di seas e.The prese ntin v entional so provid es a  s creeni ng met h od f o r  identifying com pound s capab l e o f enh an cing or inhi biting a c ellular res ponseindu ced b y an MP IF -1, M- CIF  o r MIP-4 po l ypeptide,  whic h invol ve s co nta ctingcell s which  exp re ssthe MPIF- 1 ,  M - CI Fo r M IP
 or_(e), above.
MPIF-4,_M-CIF and MIP-4Antibodies
In accordance_with yet_a_further aspect_of_the present invention,_there is provided_an antibody against such_polypeptides. In another_embodiment,_the invention provides an isolated antibody that binds specifically to an MPIF-1, M-CIF or_MIP-4_polypeptide having_an_amino_acid sequence described in (I)-,_(II)-, and/or (III)-(a), (b), (c),_(d), or_(e), above.
The invention further provides methods for isolating_antibodies_that bind specifically_to an MPIF-1, M-CIF or MIP-4 polypeptide having an_amino acid sequence as described herein._Such antibodies are_useful_diagnostically_or therapeutically as described_below.
MPIF-1, M-CIF and MIP-4Antagonists and Methods
In_accordance with yet another aspect of_the present invention, there are provided antagonists_or inhibitors of such polypeptides, which_can be used to inhibit_the action_of such polypeptides, for example,_in the treatment_of arteriosclerosis,_autoinmmune and chronic_inflammatory and infective diseases, histamine-mediated allergic_reactions, hyper-eosinophilic syndrome,_silicosis, sarcoidosis, inflammatory diseases of the_lung,_inhibition of IL-1_and_TNF,_aplastic anaemia,_and myelodysplastic syndrome._Alternatively,_such polypeptides_can_be used to inhibit production of_IL-1_and TNF-xcex1, to treat aplastic anemia, myelodysplastic_syndrome, asthma and arthritis.
Diagnostic_Assays
In_accordance with still another_aspect of the present invention,_there are provided diagnostic assays for_detecting diseases_related to_the underexpression and overexpression of the polypeptides and for detecting mutations_in the nucleic acid sequences encoding_such polypeptides.
In accordance with_yet another_aspect_of the present_invention,_there is_provided a process for utilizing such polypeptides,_or polynucleotides_encoding such polypeptides, as research reagents_for in vitro purposes_related_to scientific research, synthesis of DNA_and manufacture of DNA vectors, for_the purpose of developing therapeutics_and_diagnostics_for the treatment of human_disease.
The present invention also provides a_screening method for_identifying compounds capable of enhancing or inhibiting_a_cellular response induced by an MPIF-1,_M-CIF_or MIP-4 polypeptide, which involves contacting_cells_which_express the MPIF-1, M-CIF or_MIP