 about 55 mM, and most preferably at a concentration of about 45.8 mM. Such solutions have been found to be particularly efficacious in the preservation of platelets.
In yet another aspect, a method for the treatment of leukemia is provided, the method comprising removing bone marrow from a patient, contacting the bone marrow with a preservation composition or solution of the present invention for a period of at least about 3 days at a temperature of less than about 0xc2x0 C., more preferably between about xe2x88x924xc2x0 C. and about xe2x88x9280xc2x0 C., and most preferably at a temperature of about xe2x88x9280xc2x0 C., in order to purge the bone marrow of leukemic cells, and returning the purged bone marrow to the patient.
As detailed below, it has been found that the solutions and methods of the present invention can be employed to maintain the viability of living biological materials, including cells, tissues and organs, for longer periods of time than are generally possible with conventional preservation methods, thereby providing improved storage and transport times for biological materials for use in applications such as organ transplants and bone marrow transplants.
The preservation methods of the present invention arc less complex than many of the methods typically employed for the preservation of biological materials, thereby reducing costs and increasing the ease of use and availability of preservation procedures. Furthermore, the inventive compositions are of low toxicity, resulting in fewer negative side effects when biological materials, such as transplant organs, are returned to a patient.
The above-mentioned and additional features of the present invention and the manner of obtaining them will become apparent, and the invention will be best understood by reference to the following more detailed description, read in conjunction with the accompanying drawings. As represented by the uses of a surface protecting paint of an element for semiconductor device, a binder for die bonding adhesive, a cloth impregnated material, an organic film for orientation of a liquid crystal or a shielding film for preventing soft error of large scale integrated circuits, where a polyimide film is provided on the interface of an article wherein the surface is Si or Si--O--Si, the article has a poor adhesion to the polyimide polymer. Therefore, a method of treating the interface between the polyimide film and Si or Si--O--Si or a method of introducing an alkoxy group or siloxane group into the polyimide polymer has heretofore been employed to improve the adhesion.
Further, as the process which can
about 55 mM, and most preferably at a concentration of about 45.8 mM. Such solution have been discover to be particularly efficacious in the preservation of platelet. 
 In yet another aspect, a method for the discussion of leukemia is put up, the method consist removing bone marrow from a affected role, contacting the bone marrow with a preservation composition or solution of the present invention for a time period of at least about 3 days at a temperature of less than about 0xc2x0 C., more preferably between about xe2x88x924xc2x0 C. and about xe2x88x9280xc2x0 C., and most preferably at a temperature of about xe2x88x9280xc2x0 C., in order to purge the bone marrow of leukemic cell, and returning the purged bone marrow to the affected role. 
 As detailed below, it has been find that the solution and methods of the present invention can be employed to maintain the viability of living biological materials, include cells, tissues and organs, for longer periods of time than are generally possible with conventional preservation methods, thereby providing improved storage and transport times for biological materials for function in applications such as organ transplant and bone marrow transplants. 
 The preservation methods of the present invention discharge less complex than many of the methods typically employed for the preservation of biological materials, thereby reduce costs and increasing the ease of use and handiness of preservation procedures. Furthermore, the inventive compositions are of low toxicity, resulting in few damaging side effects when biological materials, such as transplant harmonium, are returned to a patient. 
 The above - mentioned and extra features of the present invention and the manner of receive them will become apparent, and the invention will be best understood by reference book to the following more detailed description, learn in conjunction with the accompanying drawing. As represented by the use of a surface protect paint of an chemical element for semiconductor device, a binder for die bonding adhesive, a fabric impregnated material, an organic film for orientation of a liquid crystal or a shielding film for preventing soft error of large plate integrated circuits, where a polyimide movie is provided on the interface of an article wherein the surface is Si or Si -- O -- Si, the article has a inadequate adhesion to the polyimide polymer. Therefore, a method of treat the interface between the polyimide film and Si or Si -- O -- Si or a method of introducing an alkoxy group or siloxane group into the polyimide polymer has heretofore been employed to better the adhesiveness. 
 far, as the process which can
 ablut 55 mM, and most preferanly at a concenttarion oh about 45.8 mM. Sucf solutions have been found vo bw parupcularly efficacious kn the prvservatiob of platelets.
Ii yet another zdpecc, e method for thg treatment mf leukemia is pforided, the method comprising removing bone msrgow from a patyent, sontzbtlng the bone marrow with a presedvation composition pr solution of the present invfntion for a periof of at leawt afiut 3 days at a temperauuxe of less jhan about 0xc2x0 C., more preferably betwzen about xg2r88z924xc2d0 C. and abouv xe2x88x9280qc2x0 C., and mosb prefesably ay a temperaturc of ebour xe2x88x9280xc2x0 C., in order vo purge the bone matrow of legkzmic cells, and returnunt the purced cine madrpw to thf petient.
As defailed beloq, it has been found trqt the solutikns anq iethods of the present invention can be emlloyed to maintain the ciability of living blological materials, including cells, tissues and organs, for longxr pexljaw lf time than are generally possible with convqhtookal preservation methods, thrrfbu providing imkroved stodage and transport times sor buological matrrials for use in applicatiins such as jegan transplants aud bone marruw ttansplsnts.
The preservation mechods kf the presfnt invenfkon arc less comoleq thdn many of the methods typycally em'loyeb for thd prgservatyon of biopogical materials, therebj redocing wosts and lncreasing the ease of use and etailability og [revervatiou proccdures. Furthermjre, the inventnve compjsitiuns are of low toeicity, resuleing in fewer jegative sidx effects wheb biilogicau materials, sucn as transplant orgqns, are returned tp a latient.
The abovz-otnrioned and addotiunaj veeturef of the presant knvdmtion and tht mcnver pf obtaining them winl bscome apparent, and tme inventuon will be best undetstood by referenct to tie foluowinb mjre detailed description, read jn conjunftijn with the wcconpanying dracings. As represented by the uses of a sucface protecting paint if an element for sgmigonductor detice, a binder fmr die bonding adhesuve, a cloth imprennated material, an orgznic fhlm flr orientation of a liquid crystal or a shielding film for preventing sofr erroc jf large sczle onteggatzd eircuitf, whxrx a polyimide filk is provided on the interface uf an ardiele wherein the surface is Si of Si--O--Si, the atticle has a poor adhesion to the lolyimide polymer. Therefore, a mrthod of treating the inberface bwtweeh the iklbimide film and Si ot Si--O--Sn or a method of lntroducing an allowy group og sikorane group into the polyimide poltmer hqs heretofore been employed tl imprkve thg adhesion.
Further, as fje prucess which csn
about 55 mM, and most preferably at of 45.8 mM. solutions have been in preservation of platelets. yet another aspect, method for the treatment of leukemia provided, the method comprising removing bone marrow from a patient, contacting the bone with a preservation composition or solution of the present invention for a period at about days a temperature of less than about 0xc2x0 C., more preferably between about xe2x88x924xc2x0 C. and about C., and most preferably at a temperature of xe2x88x9280xc2x0 C., in order purge the bone marrow of cells, returning the bone to patient. As detailed it has been found that the solutions and methods of the present invention can be employed to the viability biological materials, cells, and for longer periods than are generally possible with conventional providing improved storage and transport times for biological for use applications such as organ transplants and marrow transplants. The preservation methods of the present arc less complex than many of the methods typically employed for the preservation of biological reducing costs and increasing ease of use availability preservation Furthermore, inventive compositions of low toxicity, resulting in fewer negative side effects when biological such as transplant organs, are returned to a patient. The additional of the present and the manner of them become apparent, and the be understood the more description, read in conjunction the accompanying drawings. As represented the uses of a element for semiconductor device, a binder for die adhesive, a cloth impregnated material, an organic for orientation of a liquid crystal or a shielding film for preventing error of integrated circuits, where a polyimide film is provided the interface of an wherein the surface is Si or Si--O--Si, the article a adhesion to polyimide polymer. Therefore, method of treating interface between the and Si Si--O--Si a an alkoxy group or siloxane group the polymer has heretofore been employed improve Further, as the process which can
 about 55 mM, and most preferably aT a concentrAtion Of aBouT 45.8 mm. SucH solUtions have been FOund To be particularly efficaCious In THe prESeRvatiOn of plaTElETS.
In YeT aNotHeR AsPect, a MetHod for tHe treatmenT of LeUkemia is provIDeD, the method ComPrising removIng Bone maRrOw fROm a paTieNt, conTactinG The bonE marrow wiTh A PreserVAtion coMPOsItioN or solution of the pREsENt invention for A perioD oF At LEAst AboUt 3 days at a tEmPeratURe of lesS ThAN ABouT 0Xc2x0 C., more prefeRably betweeN AboUt xe2x88x924Xc2X0 C. aND about Xe2x88x9280xC2x0 c., And Most preferaBly aT a temperaTure of ABout xe2x88X9280Xc2x0 C., in oRder to PurGe tHe boNE mArRow Of LEukEMiC ceLLs, aNd returnInG tHe purGed bONE MArroW to The pAtienT.
As detailed beLow, It haS BeeN founD that The sOlUtionS and meThods Of The present invenTion Can be emplOyeD tO maInTain tHE viabiLitY of Living bIologicAL maTeRIALs, Including cells, tissUeS ANd Organs, foR longeR PeRiODs of time ThAn aRe geNERally PossIBlE with conVentioNAl PrEservatIoN methoDs, TheRebY provIDing ImprovEd storagE and tRAnsport times foR Biological matERiALS fOR use In aPplications Such AS orgAn trANsPlaNTs and Bone mArROw TRansplants.
The preserVaTion meThods Of the present iNvention arC LESs compleX thaN MaNY of the methods tYpicaLly employeD For the prEservAtion of bIological MATerials, tHerEby RedUciNG CoSts and increasING the EaSe of use And AvailabIliTy oF prEseRvAtion procEdures. FuRtHeRmOrE, thE inveNTive compOsItiOnS arE of loW ToxiciTy, resUltiNg In FEweR negatiVE sIDE effEcTs When BioLoGical MateRIalS, such as TransplanT orGAns, aRe ReTurned tO a patient.
The aBoVe-mentioneD aNd aDditioNAL featureS of the present invention aND the manNer Of obtAiniNg them wilL beCome apParENt, and tHe inveNtion WiLl bE BEst unDERsTooD bY reference TO The FolloWiNg moRe detaiLed description, read IN coNjunction with The AccoMPAnYinG DrAWinGs. aS rePREsented by the useS of a surfacE pROtEcting painT Of aN eLement fOr semicOnducTOr devicE, a binder fOr die bondInG adhESIve, A cloth imprEgnated mAterial, an ORganiC FiLm for OriEntatiOn Of a LiquiD crystAL or A shieLding fIlM for prEventInG soft errOr of large scale integrateD circuIts, whEre A polyimidE fiLM is Provided oN the Interface oF an ArtIcle wHerEIn the SurfACe Is SI Or Si--O--si, thE Article haS A pOor ADHeSion to the poLYIMidE polyMer. tHerefoRe, a mEthod of treating thE Interface betweEn thE POlyImiDE filM aNd Si or Si--O--Si or a MetHoD OF introduCiNg an alkoxy gRoup or siLoXAne grOup intO the poLyimide POLyMEr has hEretOfoRe been empLoyEd TO improvE tHe ADhesioN.
FurThEr, as thE proceSS whiCH Can
 about 55 mM, and most pre ferably at  a co nce ntr at ionof a bout 45.8 mM.S uchsolutions have been fo und t ob e pa r ti cular ly effi c ac i o usin  t hepr e se rvati onof plat elets.
Inyet  a nother aspec t ,a method f orthe treatmen t o f leuk em iai s pro vid ed, t he met h od com prising r em o ving b o ne marr o w  f roma patient, contac t in g  the bone marr ow wit ha  p r e ser vat ion compos it ion o r  soluti o no f the present inven tion for ap eri od ofat  le a st abo ut 3da y s a t a tempera ture  of lessthan a b out 0xc 2 x0 C.,more p ref era blyb et we enab o utx e2 x88 x 924 xc2x0 C.  a nd  abou t xe 2 x 8 8 x928 0xc 2x0C., a nd most prefe rab ly a t  atempe ratur e of  a boutxe2x88 x9280 xc 2x0 C., in orde r to  purge th e b on e m ar row o f  leuke mic  ce lls, an d retur n ing  t h e pu rged bone marrow t ot h epatient. 
As de t ai le d  below,it  ha s be e n  foun d th a tthe solu tionsa nd  m ethodsof  the p re sen t i nvent i on c an beemployed  to m a intain the via b ility of livi n gb i ol o gica l m aterials, i nclu d ingcell s ,tis s ues a nd or ga n s, for longer periodsof  timethanare generally  possiblew i t h conven tion a lp reservation me thods , therebyp roviding  impr oved sto rage andt r ansporttim esfor  bi o l og ical material s forus e in ap pli cations  su chasorg an  transpla nts andbo ne  m ar row  tran s plants.Th e p re ser vatio n  metho ds of  the  p re s ent  invent i on a rc l es scomp lex  t han m anyo f t he meth ods typic all y  emp lo ye d for t he preservati on  of biolog ic almateri a l s, there by reducing costs and i n creasin g t he ea se o f use and  av ailabi lit y  of pr eserva tionpr oce d u res.F u rt her mo re, the in v e nti ve co mp osit ions ar e of low toxicity, res ulting in few ernega t i ve  si d ee ffe ct s  wh e n  biological mat erials, su ch as  transplan t  or ga ns, are  return ed to a patie nt.
The a bove-ment io neda n d a dditionalfeatures  of the p r esent in venti onand th eman ner o f obta i nin g the m will  b ecomeappar en t, and t he invention will be be st und ersto odby refere nce tothe follo wing  more deta ile d d escri pti o n, re ad i n  c onj u nctio n wi t h the acc o mp any i n gdrawings. A s r epr esent edb y theuses  of a surface pro t ecting paint o f an e lem ent forse miconductor de vic e, a  binderfo r die bondi ng adhes iv e , a c loth i mpregn ated ma t e ri a l, anorga nic  film for  or ie n tationof  a liquid  cry st al ora shie l ding f ilm for preventi ng so f t  erro r  of  larg escale i n tegr ated circu its, wherea poly imid e fil m is pr ov ided o n t he  interface of an art iclewherein  t he s urf ace is  Sio r  Si-- O--S i,  th e article h as apo o r a dhes ion t othepolyimide polymer.  Th e refore,  a  me t h od oft re a t ing the in ter faceb e tween thep olyi m id e  film  and S i or S i--O--S i  or  a  method  of i ntroducin g an alko x y g ro up o r siloxa ne  gro up  in to  the polyimidepolymerhas here t o fore b een empl o yed to  i mprove the a dhesi on . 
Furthe r ,  as  the pr o ces s w hic h ca n
 about_55 mM,_and most preferably at_a concentration_of_about 45.8_mM._Such solutions have_been found to_be particularly efficacious in_the preservation of_platelets.
In_yet another aspect, a method for the treatment of leukemia is provided, the method_comprising_removing bone_marrow_from_a patient, contacting the bone_marrow with a preservation composition_or solution_of the present invention for a period of_at_least about 3_days at a temperature of less than about 0xc2x0_C., more preferably between about xe2x88x924xc2x0_C. and about_xe2x88x9280xc2x0_C.,_and most preferably at_a temperature of about xe2x88x9280xc2x0 C.,_in order to purge the bone_marrow of leukemic cells, and returning the_purged bone marrow to the patient.
As_detailed below, it has been_found that_the solutions and methods of_the present invention_can be_employed to maintain_the viability of living biological materials,_including cells, tissues_and organs, for longer periods of_time_than are generally_possible_with_conventional preservation_methods, thereby providing_improved_storage and_transport_times for biological materials for use_in_applications such as organ transplants and bone_marrow transplants.
The preservation methods_of_the present invention arc_less complex than many of_the methods typically employed for the_preservation of_biological materials,_thereby reducing costs and increasing the ease of use and availability_of preservation procedures. Furthermore, the inventive_compositions are of low_toxicity, resulting_in_fewer negative side_effects_when biological_materials, such as transplant organs, are returned_to a_patient.
The above-mentioned and additional features of_the present invention and_the_manner of obtaining them will become_apparent, and the invention will be_best understood by reference to_the_following_more detailed description, read in_conjunction with the accompanying drawings. As_represented by the_uses of a surface protecting paint of_an_element for semiconductor device, a binder_for_die bonding adhesive, a cloth impregnated_material,_an_organic film for orientation of_a liquid crystal or a shielding_film for preventing soft error of large scale integrated_circuits, where a_polyimide film is provided on_the_interface_of an article wherein the surface is Si or Si--O--Si,_the article_has a poor_adhesion to the polyimide polymer. Therefore, a method of treating_the interface between the polyimide film and_Si or Si--O--Si or a method of introducing an alkoxy group_or siloxane group into the polyimide polymer has_heretofore been employed to improve the adhesion.
Further,_as the process which_can