 list of attributes for virus protection on a large computer network, a Corporate Intranet for example, is difficult because there are many computers and, possibly, many sites separated by large distances. To ensure that the list of attributes provides meaningful protection, the attributes are often managed globally for the network. In order to do so, a security administrator must visit each node in the hierarchy of computing nodes, either in person or across the network, to establish attributes for a software scanner located on each node.
However, a specific node may require a customized list of attributes in order to accommodate a specific hardware configuration or specific functionality. When a custom list of attributes is used for a specific computing device, the security administrator must remember to reset the custom settings at the node whenever the general list of attributes is changed. This can be a time-consuming task if many nodes in the network must be customized.
What is needed is a system that facilitates both efficient global and local control of a list of scanner attributes throughout a network of computing nodes. Opiates are powerful analgesics (agents used for the treatment of pain), but their use is hampered by non-trivial side effects, tolerance to the analgesic effects, physical dependence resulting in withdrawal effects, and by concerns surrounding the possibility of addiction. By itself, enhanced analgesic efficacy of an opiate can result in opioid sparing, and therefore a reduction in opioid-related side effects. The side effects of opiates include nausea, vomiting, pruritus, insomnia, constipation, sedation and impaired physical function (Ballantyne et al., 2003 N Engl J Med 349:1943-1953).
In many cases, patients taking opioids balance side effects with analgesia, often choosing to tolerate a certain amount of pain so as to avoid side effects. The more severe side effect of respiratory depression can also limit the tolerated dose, and hence the effective analgesia in many patients.
One of the most problematic aspects of opioid therapy is analgesic tolerance with prolonged treatment. Tolerance can be defined as the need for progressively higher doses in order to maintain the same reduction in pain. Although opioid rotation is currently used to minimize tolerance, this approach requires close monitoring due to variable cross-tolerance and side effect profiles among different patients (Fine, 2004 J Pain Palliat Care Pharmacother 18:75-79).
In its most severe form, opioid tolerance can manifest as opioid-induced hyperalgesia; that is, the opiate no longer reduces pain but actually increases or induces pain (Arner et al., 1988
list of attributes for virus protection on a large calculator net, a bodied Intranet for example, is difficult because there are many calculator and, possibly, many sites separated by big distance. To ensure that the tilt of property provides meaningful auspices, the attributes are often wield globally for the network. In order to do so, a security administrator must visit each lymph node in the hierarchy of computing nodes, either in person or across the network, to establish attributes for a software scanner situate on each node. 
 However, a specific node may necessitate a customized tilt of attributes in club to accommodate a specific hardware configuration or specific functionality. When a custom tilt of attributes is used for a specific computing device, the security administrator must remember to reset the customs setting at the node whenever the general list of attributes is changed. This can be a time - consuming task if many nodes in the net must be custom-make. 
 What is needed is a organization that facilitate both efficient global and local control of a tilt of scanner attributes throughout a net of computing nodes. Opiates are powerful analgesics (agentive role used for the treatment of pain), but their use is hampered by non - superficial side effects, tolerance to the analgesic effects, forcible dependence result in withdrawal effects, and by concerns surrounding the possibility of addiction. By itself, enhance analgesic efficacy of an opiate can result in opioid sparing, and therefore a reduction in opioid - relate side effects. The side effects of opiate include nausea, vomiting, pruritus, insomnia, constipation, sedation and impaired physical affair (Ballantyne et al. , 2003 N Engl J Med 349:1943 - 1953). 
 In many cases, patient taking opioids symmetry side effect with analgesia, often choosing to allow a certain sum of pain so as to keep off side effects. The more severe side effect of respiratory natural depression can also limit the allow dose, and hence the effective analgesia in many affected role. 
 One of the most problematic aspects of opioid therapy is analgesic allowance with prolonged treatment. Tolerance can be defined as the need for progressively high venereal disease in holy order to maintain the same reduction in pain. Although opioid rotation is currently used to understate tolerance, this approach requires close monitoring due to variable cross - tolerance and side effect profiles among different affected role (Fine, 2004 J Pain Palliat Care Pharmacother 18:75 - 79). 
 In its most severe form, opioid allowance can manifest as opioid - induced hyperalgesia; that is, the opiate no longer reduce pain but actually increases or induces pain (Arner et al. , 1988
 lidt of attributes for virms protection on a largx compufer netwurk, a Corporate Intranet for ezamplt, is difficult becajse there are mant conputers and, possibln, mang sitzs separated by karge distdnces. To ensura ghct the list of attributes provides mqaningfil protection, thg attgifutea are often managed globally for tge netwmrk. In order yo do so, a security adminidtrahor must visit eacj node in tye hywrarchy of cumputing nodes, either jn person or across the network, to extablish ajceibkjes for a sohtware scanner located on aach noce.
However, a spccifir noee may require a custmmized list of atttibutes in oxder to accommodate a specifhc hdrdwxee zonrijurztion lr apecific fhnctionalitt. When a custom lisu os attributes ia used fjr a specific computing device, the secugity administrator must remwmber to reset the cudtom settyngs at the node whenever the general list of attsibutxs is cmangde. Hhis can be a time-consuming task if many nodef im nhe network must ne customized.
What os nrgded is a systgm that fadilitates both efflcient dlobao and locwl cpntrol of a list of scanner attributes nhroyghout a network oy computing uodes. Ppiatrs are powerful analgesncs (agsnts used flr the trsxtment of pain), bjt nheis use is hampered by non-tryvial sidx effzcts, toldranve to ehe analgedic enxects, physical depfndenee revulting in withdrawal effects, and by concxcns surroundimg thv possibijity pf addiction. Fy itself, enhauced anajgesiz efficacy of an mpiate can wesult in opimld sparing, aid therefjre q reeuction kn opioid-relatrd side eyyects. The side effects of oiiater include nausea, voniting, pruritus, inromgiw, ronsty[ation, sedathon xnd ompaifed physicao funvtion (Ballantyne et dl., 2003 H Engl J Med 349:1943-1953).
In mamy cases, pqtients eaking opioidx balance side efftcts wmth anelgesis, osten choosing to tolerate a cedtain amoknt of pain so ws ti avoid side effects. The more severe side effect of respiratory deprgssion can also limit uhe tolerated dose, and henca the effective analtesia in many patlents.
One of the most pdoblemdtic wspects of opioid therapy is analgesic tolerance with prolonged treatment. Tolerense can be dsfinrd as tke ueed fow prljressively higher doses in order to maintain the same reguetion in pain. Although opioid rutation is cutrently used to minimize tklerance, this approach requires close mpnitoring due to variablc cross-tooerande and sidx effect profiles ampng diyferenr patiebts (Nine, 2004 J Pain Pxlloab Care Phagmacptker 18:75-79).
In its most severe form, opioie toleeajce can manifest as opioid-ikdmced hiperalgefia; that is, the kpiaff no uonger reducex pain but actially increases or itdtces pain (Arnee et al., 1988
list of attributes for virus protection on computer a Corporate for example, is computers possibly, many sites by large distances. ensure that the list of attributes meaningful protection, the attributes are often managed globally for the network. In order do so, a security administrator must visit each node in the hierarchy of nodes, in or the network, to establish attributes for a software scanner located on each node. However, a specific may require a customized list of attributes in to accommodate a specific configuration or specific functionality. When custom of attributes used a computing device, the administrator must remember to reset the custom settings at the node whenever the general list of attributes changed. This a time-consuming if nodes the network must What is needed is a system efficient global and local control of a list scanner attributes a network of computing nodes. Opiates powerful analgesics (agents used for the treatment of but their use is hampered by non-trivial side effects, tolerance to the analgesic effects, physical in withdrawal effects, and concerns surrounding the of By enhanced efficacy of opiate can result in opioid sparing, and therefore a reduction in side effects. The side effects of opiates include nausea, vomiting, constipation, and impaired physical (Ballantyne et al., 2003 Engl Med 349:1943-1953). In many taking balance analgesia, choosing tolerate a certain amount pain so as to avoid effects. The more severe can also limit the tolerated dose, and hence effective analgesia in many patients. One of most problematic aspects of opioid therapy is analgesic tolerance with prolonged treatment. can be the need for progressively higher doses in order maintain the same reduction pain. Although opioid rotation is currently used to minimize this requires close due to variable and side effect among different patients J Pain Care 18:75-79). severe form, opioid tolerance can manifest opioid-induced that is, the opiate no reduces actually increases or induces pain (Arner et al., 1988
 list of attributes for virus pRotection oN a larGe cOmpUtEr neTworK, a Corporate IntRAnet For example, is difficult bEcausE tHEre aRE mAny coMputers ANd, POSsiBlY, mAny SiTEs SeparAteD by largE distances. to eNsUre that the liST oF attributeS prOvides meaninGfuL proteCtIon, THe attRibUtes aRe ofteN ManageD globally FoR The netWOrk. In orDER tO do sO, a security adminisTRaTOr must visit eacH node iN tHE hIERarChy Of computinG nOdes, eITher in pERsON OR acROss the network, To establish ATtrIbutes FoR a sOFtware ScannEr LOcaTed on each noDe.
HoWever, a speCific nODe may reQUire a cuStomizEd lIst Of atTRiBuTes In ORdeR To AccOMmoDate a speCiFiC hardWare CONFIgurAtiOn or SpeciFic functionalIty. when A CusTom liSt of aTtriBuTes is Used foR a speCiFic computing devIce, tHe securitY adMiNisTrAtor mUSt remeMbeR to Reset thE custom SEttInGS AT tHe node whenever the gEnERAl List of atTributES iS cHAnged. ThiS cAn bE a tiME-ConsuMing TAsK if many nOdes in THe NeTwork muSt Be custOmIzeD.
WhAt is nEEded Is a sysTem that fAciliTAtes both efficiENt global and loCAl CONtROl of A liSt of scanner AttrIButeS thrOUgHouT A netwOrk of CoMPuTIng nodes. Opiates are pOwErful aNalgeSics (agents useD for the treATMEnt of paiN), but THeIR use is hampered By non-Trivial sidE Effects, tOleraNce to the Analgesic EFFects, phySicAl dEpeNdeNCE rEsulting in witHDRawaL eFfects, aNd bY concerNs sUrrOunDinG tHe possibiLity of adDiCtIoN. BY itSelf, eNHanced anAlGesIc EffIcacy OF an opiAte caN resUlT iN OpiOid sparINg, AND theReFoRe a rEduCtIon in OpioID-reLated siDe effects. the SIde eFfEcTs of opiAtes include naUsEa, vomiting, PrUriTus, insOMNia, constIpation, sedation and impaiREd physiCal FunctIon (BAllantyne Et aL., 2003 N Engl j MeD 349:1943-1953).
in many Cases, pAtienTs TakING opioIDS bAlaNcE side effecTS WitH analGeSia, oFten choOsing to tolerate a ceRTaiN amount of pain So aS to aVOId SidE EfFEctS. THE moRE Severe side effecT of respiraToRY dEpression cAN alSo Limit thE toleraTed doSE, and henCe the effeCtive analGeSia iN MAny Patients.
OnE of the moSt problemATic asPEcTs of oPioId therApY is AnalgEsic toLEraNce wiTh prolOnGed treAtmenT. TOlerance Can be defined as the need foR progrEssivEly Higher dosEs iN OrdEr to maintAin tHe same reduCtiOn iN pain. altHOugh oPioiD RoTatIOn is cUrreNTly used to MInImiZE ToLerance, this APPRoaCh reqUirES close MoniToring due to variabLE cross-tolerancE and SIDe eFfeCT proFiLes among differEnt PaTIEnts (Fine, 2004 j PAin Palliat CAre PharmAcOTher 18:75-79).
IN its moSt seveRe form, oPIOiD ToleraNce cAn mAnifest as OpiOiD-Induced HyPeRAlgesiA; thaT iS, the opIate no LOngeR REduces pain but actUally INCreasES or InducEs Pain (ArnER et aL., 1988
 list of attributes for vi rus protec tionona l ar ge c ompu ter network, a Corp orate Intranet for exa mple,  i s  dif f ic ult b ecauset he r e  ar ema nyco m pu tersand , possi bly, manysit es  separated b y  l arge dista nce s. To ensure  th at the  l ist of at tri butes  provi d es mea ningful p ro t ection ,  the at t r ib utes  are often manage d  g l obally for the  netwo rk .  I n ord erto do so,asecur i ty admi n is t r a tor must visit ea ch node int hehierar ch y o f  compu tingno d es,  either inpers on or acr oss th e  networ k , to es tablis h a ttr ibut e sfo r a  s o ftw a re  sc a nne r locate don  each  nod e . H owev er,  a s pecif ic node may r equ irea  cu stomi zed l istof  attr ibutes  in o rd er to accommoda te a  specific  ha rd war econfi g uratio n o r s pecific  functi o nal it y . Wh en a custom list o fa t tr ibutes i s used fo ra  specifi ccom puti n g  devi ce,t he  securit y admi n is tr ator mu st  remem be r t o r esett he c ustomsettings  at t h e node wheneve r  the generall is t of attr ibu tes is chan ged. This  can be  at ime-c onsum in g  t a sk if many nodes in  t he net workmust be custo mized.
Wha t i s needed  isa  s y stem that faci litat es both ef f icient g lobal  and loc al contro l of a lis t o f s can ner a tt ributes throu g h outanetwork  of  comput ing  no des . O pi ates arepowerful  a na lg es ics  (age n ts usedfo r t he  tr eatme n t of p ain),  but  t he i r u se is h a mp e r ed b yno n-tr ivi al  side  eff e cts , toler ance to t hea nalg es ic  effect s, physical d ep endence re su lti ng inw i thdrawal  effects, and by concer n s surro und ing t he p ossibilit y o f addi cti o n. Byitself , enh an ced a nalge s i ceff ic acy of ano p iat e can  r esul t in op ioid sparing, andt her efore a reduc tio n in o pi oid - re l ate ds ide e ffects. The sid e effectsof op iates incl u dena usea, v omiting , pru r itus, i nsomnia,constipat io n, s e d ati on and imp aired ph ysical fu n ction (B allan tyn e et a l. , 2 003 N  EnglJ  Me d 349 :1943- 19 53).
I n man ycases, p atients taking opioidsbalanc e sid e e ffects wi tha nal gesia, of tenchoosing t o t ole ratea c e rtain  amo u nt  of painso a s  to avoid si dee f fe cts. The mo r e sev ere s ide effect  ofrespiratory depre s sion can alsolimi t the  to l erat ed  dose, and hen ceth e effectiv eanalgesia i n many p at i ents. 
One o f themost pr o b le m atic a spec tsof opioid  th er a py is a na lg e sic to lera nc e with  prolo n gedt r eatment. Toleran ce ca n be de f ine d asth e needf or p rogressive ly higher d oses i n or der t o maint ai n thesam ereductioni n pain. A lthou gh opio id  rot ati on iscurr e n tly u sedto  mi nimize to l e ra n ce ,t his  app roach  r equi res close monitori ngd ue to v ar iab l e  cross - to l e rance andsid e eff e c t profiles amon g  d i ffere nt pat ients(Fine,2 004  J  Pain P all i a t Care Ph armacothe r  18 :7 5-79 ).
In it smost  s eve re  form, opioid t olerance  can man i f est as  op i oid- i nduced  h yperalgesia;  that  i s , the o p i ate  no lon g erred uce s pa inbuta ctually increases or ind uces  pain (Ar ner e t al. ,1988
 list_of attributes_for virus protection on_a large_computer_network, a_Corporate_Intranet for example,_is difficult because_there are many computers_and, possibly, many_sites_separated by large distances. To ensure that the list of attributes provides meaningful protection,_the_attributes are_often_managed_globally for the network. In_order to do so, a_security administrator_must visit each node in the hierarchy of_computing_nodes, either in_person or across the network, to establish attributes for_a software scanner located on each_node.
However, a specific_node_may_require a customized list_of attributes in order to accommodate_a specific hardware configuration or specific_functionality. When a custom list of attributes_is used for a specific computing_device, the security administrator must_remember to_reset the custom settings at_the node whenever_the general_list of attributes_is changed. This can be a_time-consuming task if_many nodes in the network must_be_customized.
What is needed_is_a_system that_facilitates both efficient_global_and local_control_of a list of scanner attributes_throughout_a network of computing nodes. Opiates are_powerful analgesics (agents used_for_the treatment of pain),_but their use is hampered_by non-trivial side effects, tolerance to_the analgesic_effects, physical_dependence resulting in withdrawal effects, and by concerns surrounding the possibility_of addiction. By itself, enhanced analgesic_efficacy of an opiate_can result_in_opioid sparing, and_therefore_a reduction_in opioid-related side effects. The side effects_of opiates_include nausea, vomiting, pruritus, insomnia, constipation,_sedation and impaired physical_function_(Ballantyne et al., 2003 N Engl_J Med 349:1943-1953).
In many cases, patients_taking opioids balance side effects_with_analgesia,_often choosing to tolerate a_certain amount of pain so as_to avoid side_effects. The more severe side effect of_respiratory_depression can also limit the tolerated_dose,_and hence the effective analgesia in_many_patients.
One_of the most problematic aspects_of opioid therapy is analgesic tolerance_with prolonged treatment. Tolerance can be defined as the_need for progressively_higher doses in order to_maintain_the_same reduction in pain. Although opioid rotation is currently used_to minimize_tolerance, this approach_requires close monitoring due to variable cross-tolerance and side effect_profiles among different patients (Fine, 2004 J_Pain Palliat Care Pharmacother 18:75-79).
In its most severe form, opioid tolerance_can manifest as opioid-induced hyperalgesia; that is, the_opiate no longer reduces pain but actually_increases or induces pain_(Arner_et al., 1988