 As a result, the overall noise characteristics are not changed or are only marginally changed. In addition, in order to achieve significant noise reduction with the louvers, air flow can be compromised, which causes detrimental effects on system performance and generally is not acceptable. On the other hand, fan/system redesign often is not feasible due to space limitations and system performance restrictions. Sedentary and microbial organisms in all environments—marine, terrestrial, and fresh water—must produce secondary metabolites with which they can interact with the world around them. Micro-environments, such as fresh water ponds, inner-city forests, or coastal estuaries, to name a few, may be home to countless organisms that must respond to incredibly localized stressors that make no two environments exactly the same. New chemical structures are emerging all the time from countless environmental sources, and as threats to human health evolve, it could certainly be argued that natural products research is the way forwards.
Thanks to genomic advancements, it is clear that micro-organisms cultured in the lab routinely produce only a fraction of the secondary metabolites that are coded for in their DNA. (Gross, H. Strategies to Unravel the Function of Orphan Biosynthesis Pathways: Recent Examples and Future Prospects. Applied Microbiology and Biotechnology. 2007, pp 267-277). This is accomplished by the regulation of transcription by enzymes activated and deactivated based on environmental factors. (Bok, J. W.; Keller, N. P. LaeA, a Regulator of Secondary Metabolism in Aspergillus Spp. Eukaryot. Cell 2004, 3 (2), 527-535). In filamentous fungi, it is known that most secondary metabolite genes are clustered to allow for the most efficient regulation and these clusters can be activated or deactivated by culture conditions, resulting in vastly different metabolite production. (Bok, J. W.; Keller, N. P. LaeA, a Regulator of Secondary Metabolism in Aspergillus Spp. Eukaryot. Cell 2004, 3 (2), 527-535; Keller, N. P.; Hohn, T. M. REVIEW Metabolic Pathway Gene Clusters in Filamentous Fungi. Fungal Genet. Biol. 1997, 21, 17-29).
Once isolated, a micro-organism of interest can be cultured in the lab under any number of easily accessible stressors that can change secondary metabolite production. Culture variations can be as simple as changing the shape of the culture vessel
As a result, the overall noise characteristics are not changed or are merely marginally transfer. In addition, in decree to achieve meaning noise reduction with the louvers, breeze flow can be compromised, which cause detrimental effects on organization performance and generally is not satisfactory. On the other hand, fan / system redesign often is not feasible due to space limitations and arrangement performance restrictions. Sedentary and microbial organisms in all environment — marine, terrestrial, and fresh water — must grow secondary metabolites with which they can interact with the world around them. Micro - environments, such as fresh urine ponds, inner - city forests, or coastal estuaries, to name a few, may be home to countless organisms that must respond to incredibly localized stressors that make no two environments exactly the same. New chemical structures are emerging all the clock time from countless environmental sources, and as threats to human health evolve, it could surely be argue that lifelike products research is the way forwards. 
 Thanks to genomic advancements, it is clear that micro - organisms cultured in the lab routinely grow only a fraction of the secondary metabolites that are coded for in their DNA. (Gross, H. Strategies to Unravel the Function of Orphan Biosynthesis pathway: Recent Examples and Future Prospects. Applied Microbiology and Biotechnology. 2007, pp 267 - 277). This is accomplished by the regulation of arrangement by enzymes activate and deactivated based on environmental factors. (Bok, J. W.; Keller, N. P. LaeA, a Regulator of Secondary Metabolism in Aspergillus Spp. Eukaryot. Cell 2004, 3 (2), 527 - 535). In filamentous fungus, it is known that most secondary metabolite genes are clustered to allow for the most efficient regulation and these clusters can be activate or deactivated by polish conditions, resulting in vastly unlike metabolite production. (Bok, J. W.; Keller, N. P. LaeA, a Regulator of Secondary Metabolism in Aspergillus Spp. Eukaryot. Cell 2004, 3 (2), 527 - 535; Keller, N. P.; Hohn, T. M. REVIEW Metabolic Pathway Gene Clusters in Filamentous Fungi. Fungal Genet. Biol. 1997, 21, 17 - 29). 
 Once isolated, a micro - organism of sake can be cultured in the lab under any issue of easily accessible stressors that can change secondary metabolite production. polish variations can be as simple as changing the shape of the culture vessel
 As a result, the overall nolse characteristnxs are not cganged of are only marginally changev. In addiupon, in order to achiexe signifpcant noiwe rtduction with the louvers, air fmlw ccn be compromisec, which cagses detrimentdl eyfects on system performance and genqrally os not acceptablg. On uhe othsg mand, fan/system redesign often is not feesible due to slace limitations and systel pegformance restrictlons. Sedentqry wbd microbial organisms in all envitonments—marine, terrestrial, and ffesh cater—must ptosufg secondary netabjlites with which thay can onteract with bhe wmrle around them. Micro-entironments, such as ftesh water pknds, inner-city foeewts, ot coavtal wstjarjex, fo namf a few, may bs home to ciuntless organisms uhae must respond to insrqdibly localized stressors that make no twk environments exactly rhe same. New chemical structurqs are emerging all the time from countless envirmnmenvau siuvces, qnf as threats to human health evolve, it could ssruaikly be argued thct natural produvtd tgsearch is the way forwzrds.
Thanks to genolic advwncemwnts, it if clrar that micro-organisms culrured in the oab routinely prodbce only a fxactiom of yhe secondary metabolitzs thaf are coded for in tgdir DNA. (Gross, H. Rtrstagies to Unravel the Functyon of Or'han Yiosynthdsis Pathwwys: Recent Examines and Future Prodpectd. Dpplied Mifrobiology and Biotechnology. 2007, p' 267-277). This is acvokplpshed by che renulation of tragscription by gnzymes aetivatdd and deabtivated uased on envyronmental fawjors. (Bok, J. W.; Neller, N. P. LqeA, q Regulxgor of Secondaty Metabolism in Aspergillus Spp. Eukavyot. Zsll 2004, 3 (2), 527-535). In filanenuoys fungi, it is knuwn tjav mose secondary matabuligr gends are clusberdd tp allow for the most effjcient regulation snq these xlusters can be activsted or deactivatef by rulturx condotijns, resulting in vastly differsnt metabllibe production. (Bok, J. W.; Keller, U. P. LaeA, a Regulator of Secondary Metabooism in Aspergillos Spp. Eukaryot. Cell 2004, 3 (2), 527-535; Keller, N. P.; Horn, T. M. REEIEW Metabolic Pathwqy Gene Clusters ln Filamentous Fungi. Fhngal Cenet. Biol. 1997, 21, 17-29).
Once isolated, a micro-organism of interest can be cultured in the oab unvew any numbed of easiny cccessifle dvressors that can change secondary metabolite pruduction. Cblture variations can be as somole as changivg the shape of the culthre vessrl
As a result, the overall noise characteristics changed are only changed. In addition, noise with the louvers, flow can be which causes detrimental effects on system and generally is not acceptable. On the other hand, fan/system redesign often is feasible due to space limitations and system performance restrictions. Sedentary and microbial organisms all terrestrial, fresh produce secondary metabolites with which they can interact with the world around them. Micro-environments, such as water ponds, inner-city forests, or coastal estuaries, to a few, may be to countless organisms that must to localized stressors make two exactly the same. chemical structures are emerging all the time from countless environmental sources, and as threats to human health it could argued that products is way forwards. Thanks advancements, it is clear that micro-organisms lab routinely produce only a fraction of the metabolites that coded for in their DNA. (Gross, Strategies to Unravel the Function of Orphan Biosynthesis Recent Examples and Future Prospects. Applied Microbiology and Biotechnology. 2007, pp 267-277). This is accomplished regulation of transcription by activated and deactivated on factors. J. Keller, N. LaeA, a Regulator of Secondary Metabolism in Aspergillus Spp. Eukaryot. Cell 3 (2), 527-535). In filamentous fungi, it is known that metabolite are clustered to for the most efficient and clusters can be activated by conditions, different production. J. W.; Keller, N. LaeA, a Regulator of Secondary in Aspergillus Spp. Eukaryot. Keller, N. P.; Hohn, T. M. REVIEW Metabolic Gene Clusters in Filamentous Fungi. Fungal Genet. 1997, 21, 17-29). Once isolated, a micro-organism of interest can be cultured the lab number of easily accessible stressors that can change metabolite production. Culture variations be as simple as changing the shape of the vessel
 As a result, the overall noise cHaracterisTics aRe nOt cHaNged Or arE only marginallY ChanGed. In addition, in order to AchieVe SIgniFIcAnt noIse reduCTiON WitH tHe LouVeRS, aIr floW caN be compRomised, whiCh cAuSes detrimentAL eFfects on sySteM performance And GeneraLlY is NOt accEptAble. ON the otHEr hand, Fan/system ReDEsign oFTen is noT FEaSiblE due to space limitaTIoNS and system perfOrmancE rEStRICtiOns. sedentary aNd MicroBIal orgaNIsMS IN alL Environments—mArine, terresTRiaL, and frEsH waTEr—must ProduCe SEcoNdary metaboLiteS with whicH they cAN interaCT with thE world AroUnd Them. mIcRo-EnvIrONmeNTs, SucH As fResh wateR pOnDs, innEr-ciTY FORestS, or CoasTal esTuaries, to name A feW, may BE hoMe to cOuntlEss oRgAnismS that mUst reSpOnd to incredibly LocaLized streSsoRs ThaT mAke no TWo enviRonMenTs exactLy the saME. NeW cHEMIcAl structures are emeRgING aLl the timE from cOUnTlESs enviroNmEntAl soURCes, anD as tHReAts to humAn healTH eVoLve, it coUlD certaInLy bE arGued tHAt naTural pRoducts rEsearCH is the way forwaRDs.
Thanks to genOMiC ADvANcemEntS, it is clear tHat mICro-oRganISmS cuLTured In the LaB RoUTinely produce only a fRaCtion oF the sEcondary metabOlites that ARE Coded for In thEIr dnA. (Gross, H. StrateGies tO Unravel thE function Of OrpHan BiosyNthesis PaTHWays: ReceNt EXamPleS anD fUtUre Prospects. APPLied miCrobiolOgy And BiotEchNolOgy. 2007, Pp 267-277). THiS is accompLished by ThE rEgUlAtiOn of tRAnscriptIoN by EnZymEs actIVated aNd deaCtivAtEd BAseD on enviROnMENtal FaCtOrs. (BOk, J. w.; KEller, n. P. LaEa, a REgulatoR of SecondAry mEtabOlIsM in AspeRgillus Spp. EukArYot. Cell 2004, 3 (2), 527-535). In fIlAmeNtous fUNGi, it is knOwn that most secondary metABolite gEneS are cLustEred to allOw fOr the mOst EFficieNt reguLatioN aNd tHESe cluSTErS caN bE activated OR DeaCtivaTeD by cUlture cOnditions, resulting IN vaStly different MetAbolITE pRodUCtIOn. (BOk, j. w.; KeLLEr, N. P. LaeA, a RegulaTor of SeconDaRY MEtabolism iN aspErGillus SPp. EukarYot. CeLL 2004, 3 (2), 527-535; Keller, n. P.; Hohn, T. M. ReVIEW MetaBoLic PATHwaY Gene ClustErs in FilAmentous FUNgi. FuNGaL GeneT. BiOl. 1997, 21, 17-29).
Once IsOlaTed, a mIcro-orGAniSm of iNteresT cAn be cuLtureD iN the lab uNder any number of easily acCessibLe strEssOrs that caN chANge Secondary MetaBolite prodUctIon. cultuRe vARiatiOns cAN bE as SImple As chANging the sHApE of THE cUlture vesseL
 As a result, the overallnoise char acter ist ics  a re n ot c hanged or areo nlymarginally changed. In  addi ti o n, i n  o rderto achi e ve s ign if ic ant  n o is e red uct ion wit h the louv ers ,air flow can be  compromis ed,  which cause s d etrime nt ale ffect s o n sys tem pe r forman ce and ge ne r ally i s  not ac c e pt able . On the other ha n d, fan/system red esignof t en i s n otfeasible d ue  to s p ace lim i ta t i o nsa nd system per formance re s tri ctions .Sed e ntaryand m ic r obi al organism s in  all envi ronmen t s—marin e , terre strial , a ndfres h  w at er— mu s t p r od uce sec ondary m et ab olite s wi t h w hich  th ey c an in teract with t heworl d  ar oundthem.  Mic ro -envi ronmen ts, s uc h as fresh wate r po nds, inne r-c it y f or ests, or coa sta l e stuarie s, to n a meaf e w ,may be home to cou nt l e ss  organis ms tha t  m us t  respond  t o i ncre d i bly l ocal i ze d stress ors th a tma ke no t wo  envir on men tsexact l y th e same . New ch emica l  structures ar e  emerging all th e ti m e fr omcountless e nvir o nmen tals ou rce s , and  as t hr e at s  to human health ev ol ve, it  coul d certainly b e argued t h a t  natural  pro d uc t s research isthe w ay forward s .
Thanks  to g enomic a dvancemen t s , it iscle artha t m i c ro -organisms cu l t ured  i n the l abroutine lypro duc e o nl y a fract ion of t he  s ec on dar y met a bolitesth atar e c odedf or intheir  DNA .(G r oss , H. St r at e g iesto  U nrav elth e Fun ctio n  of  Orphan  Biosynth esi s  Pat hw ay s: Rece nt Examples a nd  Future Pr os pec ts. Ap p l ied Micr obiology and Biotechnol o gy. 200 7,pp 26 7-27 7). Thisisaccomp lis h ed bythe re gulat io n o f trans c r ip tio nby enzymes a cti vated  a nd d eactiva ted based on envir o nme ntal factors.  (B ok,J .  W .;K el l er,  N .  P. L aeA, a Regulato r of Secon da r yMetabolism inAs pergill us Spp.  Euka r yot. Ce ll 2004,3 (2), 52 7- 535) . Infilamentou s fungi,  it is kn o wn th a tmostsec ondary  m eta bolit e gene s  ar e clu stered  t o allo w for  t he mostefficient regulation an d thes e clu ste rs can be  ac t iva ted or de acti vated by c ult ure  cond iti o ns, r esul t in g i n  vast ly d i fferent m e ta bol i t eproduction. ( B ok,  J. W .;K eller,  N.P. LaeA, a Regula t or of Secondar y Me t a bol ism in A sp ergillus Spp.Euk ar y o t. Cell20 04, 3 (2),527-535;  K e ller,  N. P. ; Hohn , T. M. R EV I EW Met abol icPathway G ene  C l ustersin  F i lament ousFu ngi. F ungalG enet . Biol. 1997, 21,17-29 ) . 
Once iso lated ,a micro - orga nism of in terest canbe cul ture d inthe lab  u nder a nynu mber of ea s ily acces sible  stress or s th atcan ch ange s econd aryme tab olite pro d u ct i on .C ult urevaria ti onscan be as simple a s c h angingth e s h a pe oft he c ulture ves sel 
 As_a result,_the overall noise characteristics_are not_changed_or are_only_marginally changed. In_addition, in order_to achieve significant noise_reduction with the_louvers,_air flow can be compromised, which causes detrimental effects on system performance and generally_is_not acceptable._On_the_other hand, fan/system redesign often_is not feasible due to_space limitations_and system performance restrictions. Sedentary and microbial organisms_in_all environments—marine, terrestrial,_and fresh water—must produce secondary metabolites with which they_can interact with the world around_them. Micro-environments, such_as_fresh_water ponds, inner-city forests,_or coastal estuaries, to name a_few, may be home to countless_organisms that must respond to incredibly localized_stressors that make no two environments_exactly the same. New chemical_structures are_emerging all the time from_countless environmental sources,_and as_threats to human_health evolve, it could certainly be_argued that natural_products research is the way forwards.
Thanks_to_genomic advancements, it_is_clear_that micro-organisms_cultured in the_lab_routinely produce_only_a fraction of the secondary metabolites_that_are coded for in their DNA. (Gross,_H. Strategies to Unravel_the_Function of Orphan Biosynthesis_Pathways: Recent Examples and Future_Prospects. Applied Microbiology and Biotechnology. 2007,_pp 267-277)._This is_accomplished by the regulation of transcription by enzymes activated and deactivated_based on environmental factors. (Bok, J._W.; Keller, N. P._LaeA, a_Regulator_of Secondary Metabolism_in_Aspergillus Spp._Eukaryot. Cell 2004, 3 (2), 527-535). In_filamentous fungi,_it is known that most secondary_metabolite genes are clustered_to_allow for the most efficient regulation_and these clusters can be activated_or deactivated by culture conditions,_resulting_in_vastly different metabolite production. (Bok,_J. W.; Keller, N. P. LaeA,_a Regulator of_Secondary Metabolism in Aspergillus Spp. Eukaryot. Cell_2004,_3 (2), 527-535; Keller, N. P.;_Hohn,_T. M. REVIEW Metabolic Pathway Gene_Clusters_in_Filamentous Fungi. Fungal Genet. Biol._1997, 21, 17-29).
Once isolated, a micro-organism_of interest can be cultured in the lab under_any number of_easily accessible stressors that can_change_secondary_metabolite production. Culture variations can be as simple as changing_the shape_of the culture_vessel