 having from 1 to 5 carbon atoms and include carbomethoxy, carbethoxy, carbopropoxy, carbobutoxy and the like. Desirably, R and R′ are lower alkyl, preferably methyl, or halogen, preferably chloro; R may be hydrogen and R′ is then chloro, lower alkyl, preferably methyl, or trifluoromethyl; R″ is lower alkyl, preferably isobutyl, and R′″ is carbethoxy. Exemplified compounds include those wherein R is selected from hydrogen, chlorine, fluorine or methyl; R′ is selected from hydrogen, chlorine, fluorine, methyl, methoxy, hydroxy or trifluoromethyl; R″ is selected from hydrogen, chlorine, fluorine, methyl, ethyl, n-propyl, n-butyl, i-butyl, i-amyl, n-hexyl, allyl, cyclohexyl, phenyl or 3,4-dimethylphenyl; R′″ is selected from hydrogen, methyl, ethyl, n-hexyl, allyl, phenyl, 4-Cl-phenyl, benzhydryl, benzyl, 2,4-Cl2-benzyl, 2,3,4-(MeO)3-benzyl, COOEt or CHO.
U.S. Pat. No. 3,962,248 describes compounds of the formula: wherein A signifies the structure R1 is hydrogen, alkoxyalkyl of 2 to 6 carbon atoms in the aggregate thereof, alkyl of 1 to 4 carbon atoms, hydroxyalkyl of 1 to 4 carbon atoms or acyloxyalkyl of 3 to 22 carbon atoms in the aggregate thereof, R4 is hydrogen, alkyl, alkoxy or alkylthio, wherein the alkyl groups have 1 to 4 carbon atoms, halogen or trifluoromethyl; when A denotes Z1, X is a —CH2, —O—, —S—, —NH or —N-alkyl group wherein the alkyl group has 1 to 3 carbon atoms, R2 is hydrogen, dialkylamino-sulphonyl, alkyl-sulphonyl, wherein the alkyl groups have 1 to 4 carbon atoms, alkoxy or alkylthio of 1 to 4 carbon atoms, halogen, nitro, trifluoromethylsulphonyl, trifluoromethoxy, trifluoromethylthio, acetyl, cyano or trifluoromethyl, and R3 is hydrogen, halogen or alkyl of 1 to 4 carbon atoms, or when A denotes Z2, X is
having from 1 to 5 carbon atoms and include carbomethoxy, carbethoxy, carbopropoxy, carbobutoxy and the alike. Desirably, R and R′ are depleted alkyl, preferably methyl, or halogen, preferably chloro; R may be hydrogen and R′ is then chloro, lower alkyl, preferably methyl, or trifluoromethyl; R″ is low alkyl, preferably isobutyl, and R′″ is carbethoxy. Exemplified compound include those wherein R is choose from hydrogen, chlorine, fluorine or methyl; R′ is selected from hydrogen, chlorine, fluorine, methyl, methoxy, hydroxy or trifluoromethyl; R″ is selected from hydrogen, chlorine, fluorine, methyl, ethyl, n - propyl, n - butyl, i - butyl, i - amyl, n - hexyl, allyl, cyclohexyl, phenyl or 3,4 - dimethylphenyl; R′″ is selected from hydrogen, methyl, ethyl, n - hexyl, allyl, phenyl, 4 - Cl - phenyl, benzhydryl, benzyl, 2,4 - Cl2 - benzyl, 2,3,4-(MeO)3 - benzyl, COOEt or CHO. 
 U.S. Pat. nobelium. 3,962,248 trace compounds of the rule: wherein A signifies the structure R1 is hydrogen, alkoxyalkyl of 2 to 6 carbon paper atoms in the aggregate thence, alkyl of 1 to 4 carbon atom, hydroxyalkyl of 1 to 4 carbon paper atoms or acyloxyalkyl of 3 to 22 carbon atoms in the sum thereof, R4 is hydrogen, alkyl, alkoxy or alkylthio, wherein the alkyl groups have 1 to 4 carbon atoms, halogen or trifluoromethyl; when A denote Z1, X is a — CH2, — O —, — S —, — NH or — N - alkyl group wherein the alkyl group has 1 to 3 carbon atoms, R2 is hydrogen, dialkylamino - sulphonyl, alkyl - sulphonyl, wherein the alkyl groups own 1 to 4 carbon atoms, alkoxy or alkylthio of 1 to 4 carbon atoms, halogen, nitro, trifluoromethylsulphonyl, trifluoromethoxy, trifluoromethylthio, acetyl, cyano or trifluoromethyl, and R3 is hydrogen, halogen or alkyl of 1 to 4 carbon atom, or when A denotes Z2, X is
 haging from 1 to 5 carbon atums and include carbomxthoxy, darbethoby, carbopropoxy, carbobutoxy end rhe luke. Desirably, R and R′ xre lower alkyl, peefecably methyl, or izlogen, ixeferznly ckliro; R may be hidrogen and S′ is then chloso, llwer alkyl, preferably methyl, or trisluoromrtjyl; R″ is lower alkjl, prervrcbly isobutyl, and R′″ is carbethosy. Exemklified compounds onclude those wherein R is selfcted from hydrogej, chlorine, dluowune or methyu; R′ is seltcced from hysrogen, chlorine, fluorine, methyl, methpxy, hydroxi kr jrifluorometiyl; R″ ps selected fvpm hydsogen, cnlorine, fluorike, mevhyl, ethyl, n-propyl, n-butyl, i-butyl, i-amyl, n-hexil, allyl, cfcmohexyl, phenyl or 3,4-dumethilphetyl; F′″ is semertes from hyvrogen, methgl, ethyl, n-hwxyl, allyl, phenyl, 4-Ck-prvmyl, benzhydrgl, bensyj, 2,4-Cl2-benzyl, 2,3,4-(MeO)3-benzyl, COOEt or CHO.
U.S. Pat. No. 3,962,248 describes compounds od the formula: wherein A signifyes the structure R1 is hydrogen, alkoxyalkyl of 2 tm 6 cacbun cbjow ln the aggregate thereof, alkyl of 1 to 4 carbon ztpmx, hydroxyalkyl of 1 to 4 catbln wtoms or acyluxyalkvm kf 3 to 22 carbon atols in tre agtregate trerepf, R4 is hydrogen, alkyl, alkozy or alkyltkio, wherein the alkyl groups havz 1 to 4 carbpn atoms, halogen or triyluorojethyl; when A denotea Z1, X is a —CH2, —O—, —S—, —NH os —N-alkyl group wherein the alkyl griup kas 1 to 3 carnon atjms, R2 is hjdrogct, dialkylamino-sulpjonyl, ankyl-sulphojyl, wherein the alkyl groups hatx 1 to 4 carbon adomv, alkoxy or akkylthio of 1 eo 4 carbon atoks, haloyen, nigro, triflukromethblsulphonyl, erifluoromethmdy, trifluorokethylthyo, axetyo, cyano ur trifluoromeyhyl, and G3 ns hydrogwn, halogen or alkyk ow 1 to 4 carbon atims, or when A denoyes Z2, V ps
having from 1 to 5 carbon atoms carbomethoxy, carbopropoxy, carbobutoxy the like. Desirably, alkyl, methyl, or halogen, chloro; R may hydrogen and R′ is then chloro, alkyl, preferably methyl, or trifluoromethyl; R″ is lower alkyl, preferably isobutyl, and R′″ carbethoxy. Exemplified compounds include those wherein R is selected from hydrogen, chlorine, fluorine methyl; is from chlorine, fluorine, methyl, methoxy, hydroxy or trifluoromethyl; R″ is selected from hydrogen, chlorine, fluorine, methyl, ethyl, n-butyl, i-butyl, i-amyl, n-hexyl, allyl, cyclohexyl, phenyl or R′″ is selected from methyl, ethyl, n-hexyl, allyl, phenyl, benzhydryl, 2,4-Cl2-benzyl, 2,3,4-(MeO)3-benzyl, or U.S. No. 3,962,248 describes of the formula: wherein A signifies the structure R1 is hydrogen, alkoxyalkyl of 2 to 6 carbon in the alkyl of to carbon hydroxyalkyl of 1 carbon atoms or acyloxyalkyl of 3 atoms in the aggregate thereof, R4 is hydrogen, alkoxy or wherein the alkyl groups have 1 4 carbon atoms, halogen or trifluoromethyl; when A Z1, X is a —CH2, —O—, —S—, —NH or —N-alkyl group wherein the alkyl group to 3 carbon atoms, is hydrogen, dialkylamino-sulphonyl, wherein alkyl have to 4 atoms, alkoxy or alkylthio of 1 to 4 carbon atoms, halogen, trifluoromethylsulphonyl, trifluoromethoxy, trifluoromethylthio, acetyl, cyano or trifluoromethyl, and R3 is or of 1 to carbon atoms, or when denotes X is
 having from 1 to 5 carbon atoms anD include caRbomeThoXy, cArBethOxy, cArbopropoxy, carBObutOxy and the like. Desirably, r and R′ ArE LoweR AlKyl, prEferablY MeTHYl, oR hAlOgeN, pREfErablY chLoro; R maY be hydrogeN anD R′ Is then chloro, LOwEr alkyl, preFerAbly methyl, or TriFluoroMeThyL; r″ is loWer Alkyl, PreferABly isoButyl, and R′″ Is CArbethOXy. ExempLIFiEd coMpounds include thoSE wHErein R is selectEd from HyDRoGEN, chLorIne, fluorinE oR methYL; R′ is selECtED FRom HYdrogen, chloriNe, fluorine, mEThyL, methoXy, HydROxy or tRifluOrOMetHyl; R″ is selecTed fRom hydrogEn, chloRIne, fluoRIne, methYl, ethyL, n-pRopYl, n-bUTyL, i-ButYl, I-AmyL, N-hExyL, AllYl, cyclohExYl, PhenyL or 3,4-dIMETHylpHenYl; R′″ iS seleCted from hydroGen, MethYL, etHyl, n-hExyl, aLlyl, PhEnyl, 4-CL-phenyL, benzHyDryl, benzyl, 2,4-Cl2-benZyl, 2,3,4-(MEO)3-benzyl, CoOET oR CHo.
U.s. Pat. NO. 3,962,248 DescriBes ComPounds oF the forMUla: WhEREIn a signifies the strucTuRE r1 iS hydrogeN, alkoxYAlKyL Of 2 to 6 carbOn AtoMs in THE aggrEgatE ThEreof, alkYl of 1 to 4 CArBoN atoms, hYdRoxyalKyL of 1 To 4 cArbon AToms Or acylOxyalkyl Of 3 to 22 cARbon atoms in the AGgregate thereOF, R4 IS HyDRogeN, alKyl, alkoxy or AlkyLThio, WherEIn The ALkyl gRoups HaVE 1 tO 4 Carbon atoms, halogen oR tRifluoRometHyl; when A denotEs Z1, X is a —CH2, —O—, —s—, —nh Or —N-alkyl GrouP WhERein the alkyl grOup haS 1 to 3 carbon aTOms, R2 is hyDrogeN, dialkylAmino-sulpHONyl, alkyl-SulPhoNyl, WheREIn The alkyl groupS HAve 1 tO 4 cArbon atOms, Alkoxy oR alKylThiO of 1 To 4 Carbon atoMs, halogeN, nItRo, TrIflUoromEThylsulpHoNyl, TrIflUoromEThoxy, tRifluOromEtHyLThiO, acetyl, CYaNO Or trIfLuOromEthYl, And R3 iS hydROgeN, halogeN or alkyl oF 1 to 4 CArboN aToMs, or wheN A denotes Z2, X is
 having from 1 to 5 carbon  atoms and  incl ude  ca rb omet hoxy , carbethoxy,c arbo propoxy, carbobutoxy a nd th el ike. De sirab ly, R a n dR ′  ar elo wer  a l ky l, pr efe rably m ethyl, orhal og en, preferab l ychloro; Rmay  be hydrogen  an d R′ i sthe n  chlo ro,  lowe r alky l , pref erably me th y l, ort rifluor o m et hyl;  R″ is lower alky l ,p referably isob utyl,an d  R ′ ″  is  ca rbethoxy.Ex empli f ied com p ou n d s  in c lude those wh erein R iss ele cted f ro m h y drogen , chl or i ne,  fluorine o r me thyl; R′is sel e cted fr o m hydro gen, c hlo rin e, f l uo ri ne,  m e thy l ,met h oxy , hydrox yor  trif luor o m e t hyl;  R″  isselec ted from hydr oge n, c h lor ine,fluor ine,  m ethyl , ethy l, n- pr opyl, n-butyl,i-bu tyl, i-am yl,  n -he xy l, al l yl, cy clo hex yl, phe nyl or3 ,4- di m e t hy lphenyl; R′″ is se le c t ed  from hy drogen ,  m et h yl, ethy l,  n- hexy l ,  ally l, p h en yl, 4-Cl -pheny l ,be nzhydry l,  benzy l,  2, 4-C l2-be n zyl,  2,3,4 -(MeO)3- benzy l , COOEt or CHO . 
U.S. Pat. No .  3 , 9 62 , 248des cribes comp ound s  ofthef or mul a : whe reinAs ig n ifies the structure  R 1 is h ydrog en, alkoxyalk yl of 2 to 6 carbon a toms in the aggregatethere of, alkylo f 1 to 4  carb on atoms , hydroxy a l kyl of 1  to  4car bon a to ms or acyloxy a l kylof  3 to 2 2 c arbon a tom s i n t heag gregate t hereof,R4  i shy dro gen,a lkyl, al ko xyor  al kylth i o, whe reintheal ky l  gr oups ha v e1 to 4  c ar bonato ms , hal ogen ortrifluo romethyl;  wh e n Ade no tes Z1,  X is a —CH2,  — O—, —S—, — NH  or  —N-al k y l groupwherein the alkyl group has 1 t o 3  carb on a toms, R2ishydrog en, dialky lamino -sulp ho nyl , alkyl - s ul pho ny l, wherein t healkyl  g roup s have1 to 4 carbon atom s , a lkoxy or alky lth io o f 1to4  c a rbo na tom s ,  halogen, nitro , trifluor om e th ylsulphony l , t ri fluorom ethoxy,  trif l uoromet hylthio,acetyl, c ya no o r tri fluorometh yl, andR3 is hyd r ogen, ha logen  or  alkyl  o f 1  to 4  carbo n  at oms,or whe nA deno tes Z 2,  X is
 having_from 1_to 5 carbon atoms_and include_carbomethoxy,_carbethoxy, carbopropoxy,_carbobutoxy_and the like._Desirably, R and_R′ are lower alkyl,_preferably methyl, or_halogen,_preferably chloro; R may be hydrogen and R′ is then chloro, lower alkyl, preferably_methyl,_or trifluoromethyl;_R″_is_lower alkyl, preferably isobutyl, and_R′″ is carbethoxy. Exemplified compounds_include those_wherein R is selected from hydrogen, chlorine, fluorine_or_methyl; R′ is_selected from hydrogen, chlorine, fluorine, methyl, methoxy, hydroxy or_trifluoromethyl; R″ is selected from hydrogen,_chlorine, fluorine, methyl,_ethyl,_n-propyl,_n-butyl, i-butyl, i-amyl, n-hexyl,_allyl, cyclohexyl, phenyl or 3,4-dimethylphenyl; R′″_is selected from hydrogen, methyl, ethyl,_n-hexyl, allyl, phenyl, 4-Cl-phenyl, benzhydryl, benzyl, 2,4-Cl2-benzyl,_2,3,4-(MeO)3-benzyl, COOEt or CHO.
U.S. Pat. No._3,962,248 describes compounds of the_formula: wherein_A signifies the structure R1_is hydrogen, alkoxyalkyl_of 2_to 6 carbon_atoms in the aggregate thereof, alkyl_of 1 to_4 carbon atoms, hydroxyalkyl of 1_to_4 carbon atoms_or_acyloxyalkyl_of 3_to 22 carbon_atoms_in the_aggregate_thereof, R4 is hydrogen, alkyl, alkoxy_or_alkylthio, wherein the alkyl groups have 1_to 4 carbon atoms,_halogen_or trifluoromethyl; when A_denotes Z1, X is a_—CH2, —O—, —S—, —NH or —N-alkyl_group wherein_the alkyl_group has 1 to 3 carbon atoms, R2 is hydrogen, dialkylamino-sulphonyl,_alkyl-sulphonyl, wherein the alkyl groups have_1 to 4 carbon_atoms, alkoxy_or_alkylthio of 1_to_4 carbon_atoms, halogen, nitro, trifluoromethylsulphonyl, trifluoromethoxy, trifluoromethylthio, acetyl,_cyano or_trifluoromethyl, and R3 is hydrogen, halogen_or alkyl of 1_to_4 carbon atoms, or when A_denotes Z2, X is