 alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic and amino groups on the substituted aryl blocked by conventional blocking groups such as Boc, Cbz, formyl, and the like or substituted with xe2x80x94SO2NRR where R is hydrogen or alkyl.
xe2x80x9cCycloalkylxe2x80x9d refers to cyclic alkyl groups of from 3 to 8 carbon atoms having a single cyclic ring including, by way of example, cyclopropyl, cyclobutyl, cyclopentyl, cyclooctyl and the like. xe2x80x9cMulticyclic bridged cycloalkylxe2x80x9d refers to cycloalkyl groups having two or more rings and one or more carbon bridging atoms. Examples of multicyclic bridged cycloalkyl groups include adamantyl and the like.
xe2x80x9cCycloalkenylxe2x80x9d refers to cyclic alkenyl groups of from 3 to 8 carbon atoms having single or multiple unsaturation but which are not aromatic. xe2x80x9cMulticyclic bridged cycloalkenylxe2x80x9d refers to cycloalkenyl groups having two or more rings and one or more carbon bridging atoms.
xe2x80x9cSubstituted cycloalkylxe2x80x9d and xe2x80x9csubstituted cycloalkenylxe2x80x9d refer to a cycloalkyl and cycloalkenyl groups, preferably of from 3 to 8 carbon atoms, having from 1 to 5 substituents selected from the group consisting of oxo (xe2x95x90O), thioxo (xe2x95x90S), alkoxy, substituted alkoxy, acyl, acylamino, thiocarbonylamino, acyloxy, amino, amidino, alkylamidino, thioamidino, aminoacyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aryl, substituted aryl, aryloxy, substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, halogen, hydroxyl, cyano, nitro, carboxyl, carboxylalkyl, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl, carboxyl-substituted aryl, carboxylheteroaryl, carboxyl-substituted heteroaryl,
alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic and amino group on the substitute aryl blocked by conventional blocking groups such as Boc, Cbz, formyl, and the comparable or substituted with xe2x80x94SO2NRR where R is hydrogen or alkyl. 
 xe2x80x9cCycloalkylxe2x80x9d refers to cyclic alkyl group of from 3 to 8 carbon atoms have a single cyclic ring admit, by way of example, cyclopropyl, cyclobutyl, cyclopentyl, cyclooctyl and the like. xe2x80x9cMulticyclic bridge cycloalkylxe2x80x9d refers to cycloalkyl groups having two or more rings and one or more carbon bridging atom. Examples of multicyclic bridged cycloalkyl groups admit adamantyl and the like. 
 xe2x80x9cCycloalkenylxe2x80x9d refers to cyclic alkenyl group of from 3 to 8 carbon atom having single or multiple unsaturation but which are not aromatic. xe2x80x9cMulticyclic bridged cycloalkenylxe2x80x9d refers to cycloalkenyl groups give birth two or more rings and one or more carbon bridging atoms. 
 xe2x80x9cSubstituted cycloalkylxe2x80x9d and xe2x80x9csubstituted cycloalkenylxe2x80x9d refer to a cycloalkyl and cycloalkenyl groups, preferably of from 3 to 8 carbon paper atom, having from 1 to 5 substituents selected from the group consisting of oxo (xe2x95x90O), thioxo (xe2x95x90S), alkoxy, substituted alkoxy, acyl, acylamino, thiocarbonylamino, acyloxy, amino, amidino, alkylamidino, thioamidino, aminoacyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aryl, substituted aryl, aryloxy, substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, halogen, hydroxyl, cyano, nitro, carboxyl, carboxylalkyl, carboxyl - substituted alkyl, carboxyl - cycloalkyl, carboxyl - substituted cycloalkyl, carboxylaryl, carboxyl - substituted aryl, carboxylheteroaryl, carboxyl - substituted heteroaryl,
 alnyl, substituted alkyl, arnl, substituted atyo, hetecoaryl, aubstituged heteroaryl, heterocyclic end wubstututed heterocyclic ana amino ggoups on rhe wybstituted aryl blocked gn conreitional blockinn groups suwh as Boc, Cbz, xofmvl, and the like or substituted with ve2x80x94SO2NTR where R is hyqrogtn jr amkyl.
xe2x80x9cCycloalkylxe2x80x9d refers to cyclic alkyl groups of from 3 to 8 carbon atoms havlng a single cyclif ring inclosind, by way of ebample, cyclopropyl, cycmobutyl, cyclopentyl, cyclooctyl xnd tke like. xe2x80z9cNulhhcyclic brivged cjcloalkylxe2x80x9d refers to cyckoalkyl groups hating two or more rings anv one or more carbon bridging acoms. Examples of multuctclic brigged xycuoamkbl froups inrlude adamahtyl and thw like.
xe2x80x9cCycloalktnyjqr2x80x9d refers fo cycjis alkenyl groups of from 3 to 8 carbon atmms having single or multiple unsaturation but ahich are not aromatic. xe2x80x9cMulticyclic bridged cycloalkenflxe2x80e9d reycvs tu cjcloalkenyl groups having two or more rings ags pnv or more carbon nridging atoms.
xe2x80x9vSkbxjituted cycloaukylxe2r80s9d and xe2x80x9csubstituhed cycjoalkwnylxe2x80x9d refrr to a cycloalkyl and cyclialkenyl grolps, preferably of from 3 to 8 carbou atomx, havong from 1 to 5 substitueuts semected from the groul consisting of obo (qe2x95x90M), thioxo (xe2x95x90S), alkoxy, subseituted aokoxv, acyl, azylakino, triocarbonypamino, acyloxy, amino, amifino, clkyldmidino, thloamidino, aminoacyl, aminocarbonbkamino, aminojhimcagbonylamiuo, amikocarbonyloxy, awyl, substituteb aryl, axyloxy, substitutvd aryloxb, aryloxyaryj, substituted wryloxyaryl, ialogen, hrdrozyl, xyano, nkgro, carboxyl, csrboxylalkyl, carboxtl-substituted alkyk, cxdboxyl-cycloalkyo, cqrboxyl-substituyed cysllakkrn, carboxylarfl, cxrbucyl-sucstituttb avyl, carnoxylheteroaryl, carbmxyl-aubstituted heterosrnl,
alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, heterocyclic substituted heterocyclic amino groups on conventional groups such as Cbz, formyl, and like or substituted with xe2x80x94SO2NRR where is hydrogen or alkyl. xe2x80x9cCycloalkylxe2x80x9d refers to cyclic alkyl groups of from 3 8 carbon atoms having a single cyclic ring including, by way of example, cyclobutyl, cyclooctyl the xe2x80x9cMulticyclic bridged cycloalkylxe2x80x9d refers to cycloalkyl groups having two or more rings and one or more bridging atoms. Examples of multicyclic bridged cycloalkyl groups adamantyl and the like. refers to cyclic alkenyl groups from to 8 atoms single multiple unsaturation but are not aromatic. xe2x80x9cMulticyclic bridged cycloalkenylxe2x80x9d refers to cycloalkenyl groups having two or more rings and one more carbon xe2x80x9cSubstituted cycloalkylxe2x80x9d xe2x80x9csubstituted refer a cycloalkyl and preferably of from 3 to 8 from 1 to 5 substituents selected from the consisting of (xe2x95x90O), thioxo (xe2x95x90S), alkoxy, substituted alkoxy, acylamino, thiocarbonylamino, acyloxy, amino, amidino, alkylamidino, thioamidino, aminoacyl, aminothiocarbonylamino, aminocarbonyloxy, aryl, substituted aryl, aryloxy, substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, halogen, hydroxyl, cyano, nitro, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted carboxylaryl, carboxyl-substituted aryl, carboxyl-substituted
 alkyl, substituted alkyl, aryl, SubstituteD aryl, HetEroArYl, suBstiTuted heteroaryL, HeteRocyclic and substituted HeterOcYClic ANd Amino Groups oN ThE SUbsTiTuTed ArYL bLockeD by ConventIonal blockIng GrOups such as BoC, cbZ, formyl, and The Like or substiTutEd with Xe2X80x94So2nRR whEre r is hyDrogen OR alkyl.
Xe2x80x9cCyclOaLKylxe2x80X9D refers TO CyClic Alkyl groups of from 3 TO 8 cARbon atoms havinG a singLe CYcLIC riNg iNcluding, by WaY of exAMple, cycLOpROPYl, cYClobutyl, cycloPentyl, cycloOCtyL and thE lIke. XE2x80x9cMuLticyClIC brIdged cycloaLkylXe2x80x9d refeRs to cyCLoalkyl GRoups haVing twO or MorE rinGS aNd One Or MOre CArBon BRidGing atomS. EXaMples Of muLTICYcliC brIdgeD cyclOalkyl groups iNclUde aDAmaNtyl aNd the Like.
Xe2X80x9cCyCloalkEnylxE2x80X9d refers to cycliC alkEnyl groupS of FrOm 3 tO 8 cArbon AToms haVinG siNgle or mUltiple UNsaTuRATIoN but which are not aroMaTIC. xE2x80x9cMultIcycliC BrIdGEd cycloaLkEnyLxe2x80X9D ReferS to cYClOalkenyl Groups HAvInG two or mOrE rings AnD onE or More cARbon BridgiNg atoms.
xE2x80x9cSUBstituted cycloALkylxe2x80x9d and xE2X80x9CSUbSTituTed CycloalkenyLxe2x80X9D refEr to A CyCloALkyl aNd cycLoALkENyl groups, preferably Of From 3 to 8 CarboN atoms, having fRom 1 to 5 substITUEnts seleCted FRoM The group consisTing oF oxo (xe2x95x90O), tHIoxo (xe2x95x90s), alkoXy, substiTuted alkoXY, Acyl, acylAmiNo, tHioCarBONyLamino, acyloxy, AMIno, aMiDino, alkYlaMidino, tHioAmiDinO, amInOacyl, aminOcarbonyLaMiNo, AmInoThiocARbonylamInO, amInOcaRbonyLOxy, aryL, subsTituTeD aRYl, aRyloxy, sUBsTITuteD aRyLoxy, AryLoXyaryL, subSTitUted aryLoxyaryl, hAloGEn, hyDrOxYl, cyano, Nitro, carboxyl, CaRboxylalkyL, cArbOxyl-suBSTituted aLkyl, carboxyl-cycloalkyl, cARboxyl-sUbsTitutEd cyCloalkyl, cArbOxylarYl, cARboxyl-SubstiTuted ArYl, cARBoxylHETeRoaRyL, carboxyl-sUBStiTuted HeTeroAryl,
 alkyl, substituted alkyl,  aryl, sub stitu ted  ar yl , he tero aryl, substitu t ed h eteroaryl, heterocycli c and  s u bsti t ut ed he terocyc l ic a ndam in o g ro u ps  on t hesubstit uted arylblo ck ed by conven t io nal blocki nggroups suchasBoc, C bz , f o rmyl,  an d the  likeo r subs tituted w it h  xe2x8 0 x94SO2N R R  w here  R is hydrogen or al k yl.
xe2x80x9cC ycloal ky l xe 2 x 80x 9drefers tocy clica lkyl gr o up s o f f r om 3 to 8 car bon atoms h a vin g a si ng lec yclicringin c lud ing, by way  ofexample,cyclop r opyl, c y clobuty l, cyc lop ent yl,c yc lo oct yl and th e l i ke.  xe2x80x 9c Mu lticy clic b r i dged  cy cloa lkylx e2x80x9d refe rsto c y clo alkyl  grou ps h av ing t wo ormoreri ngs and one ormore  carbon b rid gi ngat oms.E xample s o f m ulticyc lic bri d ged  c y c l oa lkyl groups includ ea d am antyl an d thel ik e. xe2x80x9 cC ycl oalk e n ylxe2 x80x 9 drefers t o cycl i cal kenyl g ro ups of  f rom  3to 8c arbo n atom s having  sing l e or multipleu nsaturation b u tw h ic h  are  no t aromatic.  xe2 x 80x9 cMul t ic ycl i c bri dgedcy c lo a lkenylxe2x80x9d ref er s to c ycloa lkenyl groups  having tw o o r more r ings an d  one or more c arbon  bridginga toms.
xe 2x80x 9cSubsti tuted cyc l o alkylxe2 x80 x9d  an d x e 2 x8 0x9csubstitut e d  cyc lo alkenyl xe2 x80x9dref ertoa c yc loalkyl a nd cyclo al ke ny lgro ups,p referabl yoffr om3 to8  carbo n ato ms,ha vi n g f rom 1 t o  5 s ubst it ue ntssel ec ted f romt hegroup c onsisting  of oxo(x e2 x95x90O ), thioxo (xe 2x 95x90S), a lk oxy , subs t i tuted al koxy, acyl, acylamino,t hiocarb ony lamin o, a cyloxy, a min o, ami din o , alky lamidi no, t hi oam i d ino,a m in oac yl , aminocar b o nyl amino ,amin othioca rbonylamino, amino c arb onyloxy, aryl , s ubst i t ut eda ry l , a ry l oxy , substituted ary loxy, aryl ox y ar yl, substi t ute daryloxy aryl, h aloge n , hydro xyl, cyan o, nitro,  c arbo x y l,carboxylal kyl, car boxyl-sub s titut e dalkyl , c arboxy l- cyc loalk yl, ca r box yl-su bstitu te d cycl oalky l,  carboxy laryl, carboxyl-substit uted a ryl,car boxylhete roa r yl,  carboxyl -sub stituted h ete roa ryl,
 alkyl,_substituted alkyl,_aryl, substituted aryl, heteroaryl,_substituted heteroaryl,_heterocyclic_and substituted_heterocyclic_and amino groups_on the substituted_aryl blocked by conventional_blocking groups such_as_Boc, Cbz, formyl, and the like or substituted with xe2x80x94SO2NRR where R is hydrogen_or_alkyl.
xe2x80x9cCycloalkylxe2x80x9d refers_to_cyclic_alkyl groups of from 3_to 8 carbon atoms having_a single_cyclic ring including, by way of example, cyclopropyl,_cyclobutyl,_cyclopentyl, cyclooctyl and_the like. xe2x80x9cMulticyclic bridged cycloalkylxe2x80x9d refers to cycloalkyl groups_having two or more rings and_one or more_carbon_bridging_atoms. Examples of multicyclic_bridged cycloalkyl groups include adamantyl and_the like.
xe2x80x9cCycloalkenylxe2x80x9d refers to cyclic alkenyl_groups of from 3 to 8 carbon_atoms having single or multiple unsaturation_but which are not aromatic._xe2x80x9cMulticyclic bridged_cycloalkenylxe2x80x9d refers to cycloalkenyl groups_having two or_more rings_and one or_more carbon bridging atoms.
xe2x80x9cSubstituted cycloalkylxe2x80x9d and_xe2x80x9csubstituted cycloalkenylxe2x80x9d refer_to a cycloalkyl and cycloalkenyl groups,_preferably_of from 3_to_8_carbon atoms,_having from 1_to_5 substituents_selected_from the group consisting of oxo_(xe2x95x90O),_thioxo (xe2x95x90S), alkoxy, substituted alkoxy, acyl, acylamino,_thiocarbonylamino, acyloxy, amino, amidino,_alkylamidino,_thioamidino, aminoacyl, aminocarbonylamino, aminothiocarbonylamino,_aminocarbonyloxy, aryl, substituted aryl, aryloxy,_substituted aryloxy, aryloxyaryl, substituted aryloxyaryl, halogen,_hydroxyl, cyano,_nitro, carboxyl,_carboxylalkyl, carboxyl-substituted alkyl, carboxyl-cycloalkyl, carboxyl-substituted cycloalkyl, carboxylaryl, carboxyl-substituted aryl, carboxylheteroaryl, carboxyl-substituted_heteroaryl,