 Th2-driven disorders and conditions.
We have identified the critical role of Itk in regulating important mast cell and basophil functions and established that the activity of mast cells or basophils may be inhibited through inhibition of Itk. Thus Itk inhibitors may be used as pharmaceutical agents for the treatment of mast cell-driven or basophil-driven conditions or diseases. In particular, we have identified Itk as a target for inhibiting several key events in both acute and late phase allergic reactions common to allergic rhinitis and asthma.
EP 209 707 discloses particular fused imidazo derivatives, including some imidazopyridines, and their use as potential cardiovascular agents.
DE 2 305 339 and U.S. Pat. No. 3,985,891 disclose certain imidazopyridine derivatives potentially useful as cardiotonics, anticoagulants and as agents for altering blood pressure.
WO 01/96336 discloses certain imidazopyridine derivatives that are useful as inhibitors of the enzyme 15-lipoxygenase.
None of the above publications are concerned with compounds that have utility as inhibitors of the kinase Itk.
The present invention discloses 2-aryl-substituted derivatives of 6-substituted-3H-imidazo[4,5-b]pyridines that are useful as Itk inhibitors. 1. Field of Invention
The present invention relates to the speed governors and distributing valves for hydraulic turbines and pump turbines, and particularly to three-way distributing valves for the speed governor of hydraulic turbines or the like.
2. Related Art
Three-way distributing valves are used in a speed governor for controlling a hydraulic servomotor driving the guide vanes for adjusting the volume of water that enters a hydraulic turbine or a pump turbine. An example of the three-way distributing valve for the speed governor of hydraulic turbines or pump turbines is disclosed in Patent Document 1, in which a hydraulic amplifier (three-way distributing valve) is disposed such that the plunger (main valve) can be moved vertically. The plunger is driven by a control piston that is vertically moved by pressure oil supplied via a pilot valve. Because the plunger is adapted to be moved up and down by the control piston, the control piston is directly connected to the main valve in an integral structure.
Patent Document 1: JP Patent Publication (Kokai) No. 2000-18145 A Many fruits and vegetables have tough outer skins or rinds that are not easily pierced without damaging the soft inner pulp.
Th2 - driven disorders and conditions. 
 We have identified the critical function of Itk in determine important mast cell and basophil functions and establish that the activity of mast cells or basophil may be inhibited through inhibition of Itk. Thus Itk inhibitor may be use as pharmaceutical agents for the discussion of mast cell - driven or basophil - driven conditions or disease. In particular, we have identified Itk as a prey for inhibiting several cardinal events in both acute and late phase allergic reaction common to allergic rhinitis and asthma. 
 EP 209 707 discloses particular blend imidazo derivatives, include some imidazopyridines, and their use as potential cardiovascular agents. 
 DE 2 305 339 and U.S. Pat. No. 3,985,891 disclose sealed imidazopyridine derivatives potentially useful as cardiotonics, anticoagulants and as agents for altering blood atmospheric pressure. 
 WO 01/96336 discloses certain imidazopyridine derivatives that are useful as inhibitors of the enzyme 15 - lipoxygenase. 
 None of the above publications are concerned with compounds that have utility as inhibitor of the kinase Itk. 
 The present invention unwrap 2 - aryl - substituted derivative of 6 - substituted-3H - imidazo[4,5 - b]pyridines that are utilitarian as Itk inhibitor. 1. Field of Invention 
 The present invention relates to the speed governors and distributing valves for hydraulic turbines and pump turbines, and peculiarly to three - way distributing valves for the speed governor of hydraulic turbines or the like. 
 2. Related Art 
 Three - way distributing valves are used in a speed governor for controlling a hydraulic servomotor drive the guide vanes for adjust the volume of water that enters a hydraulic turbine or a pump turbine. An example of the three - direction distributing valve for the speed governor of hydraulic turbines or pump turbine is disclosed in Patent Document 1, in which a hydraulic amplifier (three - means distributing valve) is disposed such that the diver (main valve) can be moved vertically. The speculator is driven by a control condition piston that is vertically moved by press oil add via a pilot valve. Because the plunger is adapted to be moved up and down by the control piston, the command piston is directly connected to the main valve in an integral structure. 
 Patent Document 1: JP Patent Publication (Kokai) No. 2000 - 18145 A Many fruits and vegetables have rugged outer skins or rind that are not easily pierced without damaging the soft inner pulp.
 Th2-friven disorders and conaitions.
We have neentifmed the criticau role of Itk in regulating mmpoetant mast cell and basophiu functiojs and ewtaboushed that the actlrity kn masc rells or basophlls may be hnhibited throggf nnhibition of Itk. Thus Itk inhibitorf may br ksed as pharmaseutpcwl afvnus for the treatment of mast cell-sriven mr basophil-droven conditions or diseased. In particular, we havf identifiee Ith as a target for inhibpcing severam key events in both acute and uate 'hase allertix rfdctions comnon tj allergic rmpnitis dnd astnma.
EP 209 707 discloxes paeticular fused imidazm derivatives, incloding some ijidazopyridines, abd theit use as oitevtizl czrdiovwscnlar agents.
SE 2 305 339 and U.W. Pat. No. 3,985,891 disclose vewnsin imidazopgridinq qerivatives potentially useful as cardimtohics, anticoagulants and as agents for alterijg blood [ressure.
WO 01/96336 discloses certain imidazopyridine derhvatiter tkqt ard udeful as inhibitors of the enzyme 15-lipoxygenasq.
Home of the above iublications are cpnfetged with compuunds cgaf have utility as lnhibitjrs od the kinwse Otk.
The present invention diwcloses 2-aryl-fybstituted derivatnves of 6-subscitutec-3H-imicazo[4,5-b]pyridines that are userul as Itk lnhibitora. 1. Field of Invengiok
Tha presenu invention relatef to the wpeeb governurs snd diftributing valvcv for hydraulic tugbined dnd pump tkrbines, and particularly to thrxx-way distribujinc vdlves fox the xpeed governow of hydraulic turbinzs or ghe like.
2. Rvlated Arv
Three-way diftributing vanges are used in a spqed toveenor fof controlling a hydraulib fervimotor driving the gukse vanes for adlbsuibg the volume pf datqr tiat egders a hydraglic tufnine ur a pump tmrbkne. Sn example of the thsee-wzy distributing vakvc for the speed gjvernor of hycraulic turbines og pum' turbmnes ix dysclosed in Patent Document 1, ih which a hyqraulic amplyfiev (thtee-way distxibuting valve) is disposed such that the plunger (main valvw) can be moved vertncslly. The plnnger ys driven by a control piston that is verticalky moved by pressure kil su[plief via a pilot valve. Because the plunger is adapted to be moved up and dowb by tie control piaton, the boncrok pistjn id directly connecned to the main valve in an intejral strucduxe.
Patent Document 1: JP Patent Luclication (Kokxi) No. 2000-18145 A Many fruits and vegetabkes have tough outer skins or ronds that are not easily pierced withkut damagiig the soft inner pukp.
Th2-driven disorders and conditions. We have identified role Itk in important mast cell that activity of mast or basophils may inhibited through inhibition of Itk. Thus inhibitors may be used as pharmaceutical agents for the treatment of mast cell-driven basophil-driven conditions or diseases. In particular, we have identified Itk as a target inhibiting key in acute and late phase allergic reactions common to allergic rhinitis and asthma. EP 209 707 discloses fused imidazo derivatives, including some imidazopyridines, and their as potential cardiovascular agents. 2 305 339 and U.S. No. disclose certain derivatives useful cardiotonics, anticoagulants and agents for altering blood pressure. WO 01/96336 discloses certain imidazopyridine derivatives that are useful as inhibitors of enzyme 15-lipoxygenase. the above are with that have utility of the kinase Itk. The present derivatives of 6-substituted-3H-imidazo[4,5-b]pyridines that are useful as Itk 1. Field Invention The present invention relates to speed governors and distributing valves for hydraulic turbines pump turbines, and particularly to three-way distributing valves for the speed governor of hydraulic turbines like. 2. Related Art distributing valves are in speed for a hydraulic driving the guide vanes for adjusting the volume of water that a hydraulic turbine or a pump turbine. An example of distributing for the speed of hydraulic turbines or turbines disclosed in Patent Document which hydraulic valve) disposed that the plunger (main can be moved vertically. The is driven by a moved by pressure oil supplied via a pilot Because the plunger is adapted to be up and down by the control piston, the control piston is directly to the in an integral structure. Patent Document 1: JP Publication (Kokai) No. 2000-18145 Many fruits and vegetables have tough outer skins or that not easily without damaging the inner pulp.
 Th2-driven disorders and condiTions.
We havE idenTifIed ThE criTicaL role of Itk in reGUlatIng important mast cell anD basoPhIL funCTiOns anD establIShED ThaT tHe ActIvITy Of masT ceLls or baSophils may Be iNhIbited througH InHibition of itk. thus Itk inhibItoRs may bE uSed AS pharMacEuticAl agenTS for thE treatmenT oF Mast ceLL-driven OR BaSophIl-driven conditionS Or DIseases. In partiCular, wE hAVe IDEntIfiEd Itk as a taRgEt for INhibitiNG sEVERal KEy events in botH acute and laTE phAse allErGic REactioNs comMoN To aLlergic rhinItis And asthma.
eP 209 707 discLOses parTIcular fUsed imIdaZo dErivATiVeS, inClUDinG SoMe iMIdaZopyridiNeS, aNd theIr usE AS POtenTiaL carDiovaScular agents.
De 2 305 339 anD U.S. PAT. No. 3,985,891 DisclOse ceRtaiN iMidazOpyridIne deRiVatives potentiaLly uSeful as caRdiOtOniCs, AnticOAgulanTs aNd aS agents For alteRIng BlOOD PrEssure.
WO 01/96336 discloses cErTAIn ImidazopYridinE DeRiVAtives thAt Are UsefUL As inhIbitORs Of the enzYme 15-lipOXyGeNase.
NonE oF the abOvE puBliCatioNS are ConcerNed with cOmpouNDs that have utilITy as inhibitorS Of THE kINase itk.
the present iNvenTIon dIsclOSeS 2-arYL-subsTitutEd DErIVatives of 6-substituteD-3H-ImidazO[4,5-b]pyrIdines that are Useful as ItK INHibitors. 1. fielD Of iNvention
The preSent iNvention reLAtes to thE speeD governoRs and distRIButing vaLveS foR hyDraULIc Turbines and puMP TurbInEs, and paRtiCularly To tHreE-waY diStRibuting vAlves for ThE sPeEd GovErnor OF hydraulIc TurBiNes Or the LIke.
2. RelAted ARt
ThReE-wAY diStributINg VALves ArE uSed iN a sPeEd govErnoR For ControlLing a hydrAulIC serVoMoTor drivIng the guide vaNeS for adjustInG thE volumE OF water thAt enters a hydraulic turbiNE or a pumP tuRbine. an exAmple of thE thRee-way DisTRibutiNg valvE for tHe SpeED GoverNOR oF hyDrAulic turbiNES or Pump tUrBineS is discLosed in Patent DocumENt 1, iN which a hydrauLic AmplIFIeR (thREe-WAy dIsTRibUTIng valve) is dispoSed such thaT tHE pLunger (main VAlvE) cAn be movEd vertiCally. tHe plungEr is driveN by a contrOl PistON ThaT is verticaLly moved By pressurE Oil suPPlIed viA a pIlot vaLvE. BeCause The pluNGer Is adaPted to Be Moved uP and dOwN by the coNtrol piston, the control piSton is DirecTly Connected To tHE maIn valve in An inTegral struCtuRe.
PAtent docUMent 1: Jp PatENt pubLIcatiOn (KoKAi) No. 2000-18145 A Many FRuIts AND vEgetables haVE TOugH outeR skINs or riNds tHat are not easily piERced without damAginG THe sOft INner PuLp.
 Th2-driven disorders andconditions .
Wehav e i de ntif iedthe critical r o le o f Itk in regulating im porta nt mast ce ll an d basop h il f unc ti on s a nd es tabli she d thatthe activi tyof  mast cellso rbasophilsmay  be inhibite d t hrough  i nhi b ition  of  Itk.  ThusI tk inh ibitors m ay be use d  as pha r m ac euti cal agents for th e  t r eatment of mas t cell -d r iv e n  or  ba sophil-dri ve n con d itionso rd i s eas e s. In particu lar, we hav e  id entifi ed  It k  as atarge tf orinhibitingseve ral key e ventsi n botha cute an d late  ph ase  all e rg ic  re ac t ion s  c omm o n t o allerg ic  r hinit is a n d a sthm a.EP 2 09 70 7 discloses p art icul a r f usedimida zo d er ivati ves, i nclud in g some imidazop yrid ines, and  th ei r u se  as p o tentia l c ard iovascu lar age n ts. 
D E 2  3 05 339 and U.S. Pa t. N o.  3,985,8 91 dis c lo se certainim ida zopy r i dinederi v at ives pot ential l yus eful as  c ardiot on ics , a ntico a gula nts an d as age nts f o r altering blo o d pressure.
W O  0 1 / 96 3 36 d isc loses certa in i m idaz opyr i di ned eriva tives  t h at are useful as inhib it ors of  theenzyme 15-lip oxygenase. N o ne of th e ab o ve publications a re co ncerned wi t h compou nds t hat have  utilitya s  inhibit ors  of  th e k i n as e Itk.
The pr e s entin vention  di scloses  2- ary l-s ubs ti tuted der ivatives  o f6- su bst itute d -3H-imid az o[4 ,5 -b] pyrid i nes th at ar e us ef ul asItk inh i bi t o rs.1.  F ield  of  I nvent ionT hepresent  inventio n r e late sto  the sp eed governors  a nd distrib ut ing  valve s for hydr aulic turbines and pump turbine s,and p arti cularly t o t hree-w ayd istrib utingvalve sfor t he sp e e dgov er nor of hyd r a uli c tur bi nesor thelike.
2. Related A r t
T hree-way dist rib utin g va lve s  a r e u se d  in a  speed governor  for contr ol l in g a hydrau l icse rvomoto r drivi ng th e  guidevanes for  adjustin gthev o lum e of water  that en ters a hy d rauli c  t urbin e o r a pu mp  tu rbine . An e x amp le of  the t hr ee-way  dist ri buting v alve for the speed gove rnor o f hyd rau lic turbi nes orpump turb ines  is disclo sed  in  Pate ntD ocume nt 1 ,  i n w h ich a  hyd r aulic amp l if ier ( th ree-way dis t r i but ing v alv e ) is d ispo sed such that the plunger (mainvalv e )  ca n b e  mov ed  vertically. T hepl u n ger is d ri ven by a co ntrol pi st o n tha t is v ertica lly mov e d  b y  press ureoil  supplied  vi aa  pilotva lv e . Beca useth e plun ger is adap t e d to be moved up  andd o wn by the  cont ro l pisto n , th e controlpiston is d irectl y co nnect ed to t he  mainval ve  in an int e gral stru cture .
Paten tDocu men t 1: J P Pa t e nt Pu blic at ion  (Kokai)N o .2 00 0- 1 814 5 AManyfr uits  and vege t ables ha vet ough ou te r s k i ns orr in d s  that arenot  easi l y  pierced w i thou t  d a magin g thesoft i nner pu l p.
 Th2-driven_disorders and_conditions.
We have identified the_critical role_of_Itk in_regulating_important mast cell_and basophil functions_and established that the_activity of mast_cells_or basophils may be inhibited through inhibition of Itk. Thus Itk inhibitors may be_used_as pharmaceutical_agents_for_the treatment of mast cell-driven_or basophil-driven conditions or diseases._In particular,_we have identified Itk as a target for_inhibiting_several key events_in both acute and late phase allergic reactions common_to allergic rhinitis and asthma.
EP 209_707 discloses particular_fused_imidazo_derivatives, including some imidazopyridines,_and their use as potential cardiovascular_agents.
DE 2 305 339 and U.S._Pat. No. 3,985,891 disclose certain imidazopyridine derivatives_potentially useful as cardiotonics, anticoagulants and_as agents for altering blood_pressure.
WO 01/96336_discloses certain imidazopyridine derivatives that_are useful as_inhibitors of_the enzyme 15-lipoxygenase.
None_of the above publications are concerned_with compounds that_have utility as inhibitors of the_kinase_Itk.
The present invention_discloses_2-aryl-substituted_derivatives of_6-substituted-3H-imidazo[4,5-b]pyridines that are_useful_as Itk_inhibitors._1. Field of Invention
The present invention_relates_to the speed governors and distributing valves_for hydraulic turbines and_pump_turbines, and particularly to_three-way distributing valves for the_speed governor of hydraulic turbines or_the like.
2._Related Art
Three-way_distributing valves are used in a speed governor for controlling a_hydraulic servomotor driving the guide vanes_for adjusting the volume_of water_that_enters a hydraulic_turbine_or a_pump turbine. An example of the three-way_distributing valve_for the speed governor of hydraulic_turbines or pump turbines_is_disclosed in Patent Document 1, in_which a hydraulic amplifier (three-way distributing_valve) is disposed such that_the_plunger_(main valve) can be moved_vertically. The plunger is driven by_a control piston_that is vertically moved by pressure oil_supplied_via a pilot valve. Because the_plunger_is adapted to be moved up_and_down_by the control piston, the_control piston is directly connected to_the main valve in an integral structure.
Patent Document 1:_JP Patent Publication_(Kokai) No. 2000-18145 A Many_fruits_and_vegetables have tough outer skins or rinds that are not_easily pierced_without damaging the_soft inner pulp.