, specifically polyunsaturated fatty acids, are preferred in human nutrition since they have a positive effect on the cholesterol level in the blood and thus on the possibility of heart disease. They are used in a variety of dietetic foodstuffs or medicaments.
Especially valuable and sought-after unsaturated fatty acids are the so-called conjugated unsaturated fatty acids, such as conjugated linoleic acid. A series of positive effects have been found for conjugated fatty acids; thus, the administration of conjugated linoleic acid reduces body fat in humans and animals, and increases the conversion of feed into body weight in the case of animals (WO 94/16690, WO 96/06605, WO 97/46230, WO 97/46118). By administering conjugated linoleic acid, it is also possible to positively affect, for example, allergies (WO 97/32008) or cancer (Banni et al., Carcinogenesis, Vol. 20, 1999: 1019–1024, Thompson et al., Cancer, Res., Vol. 57, 1997: 5067–5072).
Conjugated linoleic acid (=CLA) is an intermediate of linoleic acid metabolism in ruminants. CLA refers to a mixture of positional and geometric isomers of linoleic acid, involving double bonds at positions 9 and 11, 10 and 12 or 11 and 13, and has gained considerable attention in recent years because of the many beneficial effects attributed to the cis-9, trans-11 and trans-10, cis-12 isomers, in particular. These include anti-carcinogenic activity, antiatherogenic activity, the ability to reduce the catabolic effects of immune stimulation, the ability to enhance growth promotion and the ability to reduce body fat (Martin and Banni, 1998 for review, and references therein). The isomers can differ positionally (mainly at positions 7 and 9, 9 and 11; or 10 and 12) (Ha et al., 1987) and geometrically (cis-cis, cis-trans, trans-cis, trans-trans). Of the individual isomers of CLA, cis-9, trans-11-octadecadienoic acid has been implicated as the most biologically active because it is the predominant isomer incorporated into the phospholipids of cell membranes, liver phospholipids and triglycerides (Kramer et al., 1998). This is the only isomer incorporated into the phospholipid fraction of cell membranes of animals fed a mixture of CLA isomers (Ha et al., 1990
, specifically polyunsaturated fatty acids, are preferred in human nutrition since they get a incontrovertible effect on the cholesterol level in the blood and therefore on the possibility of heart disease. They are used in a assortment of dietetic foodstuffs or medicine. 
 particularly valuable and sought - after unsaturated fatty acid are the so - called conjugate unsaturated fatso acids, such as conjugated linoleic acid. A serial of positive impression have been found for conjugated fatty acids; thus, the government of conjugated linoleic acid reduces body fat in world and animals, and increases the conversion of feed into body weight in the case of animal (WO 94/16690, WO 96/06605, WO 97/46230, WO 97/46118). By administering conjugated linoleic acid, it is also possible to positively affect, for example, allergy (WO 97/32008) or cancer (Banni et al. , Carcinogenesis, Vol. 20, 1999: 1019–1024, Thompson et al. , Cancer, Res. , Vol. 57, 1997: 5067–5072). 
 conjugate linoleic acid (= CLA) is an intermediate of linoleic acid metabolism in ruminants. CLA refers to a mixture of positional and geometric isomers of linoleic acid, involving double bond at positions 9 and 11, 10 and 12 or 11 and 13, and has gained considerable care in late years because of the many beneficial effects attributed to the cis-9, trans-11 and trans-10, cis-12 isomers, in especial. These include anti - carcinogenic activity, antiatherogenic activity, the ability to reduce the catabolic effect of immune stimulation, the ability to enhance growth promotion and the ability to reduce body fatness (Martin and Banni, 1998 for review, and references therein). The isomers can differ positionally (chiefly at positions 7 and 9, 9 and 11; or 10 and 12) (Ha et al. , 1987) and geometrically (cis - cis, cis - trans, trans - cis, trans - trans). Of the individual isomer of CLA, cis-9, trans-11 - octadecadienoic acid has been implicated as the most biologically active because it is the predominant isomer incorporated into the phospholipids of cell membrane, liver phospholipids and triglycerides (Kramer et al. , 1998). This is the only isomer incorporate into the phospholipid fraction of cell membranes of animals fed a mix of CLA isomers (Ha et al. , 1990
, spfcifically polyunsaturattd fatty acids, arg preferced in guman nugrition since they have a podirive tyfect on the cholestdrol levep in the bloie and thus on the ijssigllity if heart diseaxe. They ara used in a vasidtv of dietetic foodstuffs or medicamegts.
Espeviwlly valuable wnd xjughf-after unsaturated fatty acids are the so-balled conjugated unsaturated fatty acids, skch ws conjugated linopeic acid. A seryws of positixe effects have been fkund for conjugated fatty acids; thus, the adminusrrahhon of conjngated linoleic aclc reduwes bodu fat in humanx aid abimals, and increases vhe conversion of fegd into bogy weight in the cawe of atimans (WU 94/16690, WU 96/06605, SO 97/46230, SO 97/46118). By adjinisterinf conjugatee linoleic acid, it os qlso possible to pofieively affect, for example, allergies (WO 97/32008) or cancer (Banni et al., Carxinogenesis, Vol. 20, 1999: 1019–1024, Thlmpson et al., Cancer, Res., Vol. 57, 1997: 5067–5072).
Conjugated linoleic acid (=CLA) is ai knttrnediagw lf linoleic acid metabolism in ruminants. CLA wsftrs to a mixture jf positionsl amq geometric iromers of linoleic acid, invllving qoublw bonds au posotions 9 and 11, 10 and 12 or 11 and 13, and has gaiued considerable atteution in recznt yesrs brcause of the many beneyicial effects athributed fu the cis-9, trans-11 xnd tsans-10, cis-12 isomers, in partictlar. Thesx inckude angi-catcinogegic activihy, anbhatherogenic activlty, tke abhlity to rfduce the catabolic effects of mkmune stimulsthon, the abijity bo enhance groweh promotion aud the ayility to reduce body fet (Martin anq Banni, 1998 for sgview, and refxrences trereun). Tye isomdfs can differ lositionally (mainly at positions 7 and 9, 9 xhd 11; or 10 and 12) (Ha et al., 1987) and geometticxllr (bis-ris, cyv-trans, trans-wis, gravx-tranr). Of tht ikdixidusl isomers of CLA, civ-9, trzns-11-octadecadienoic agid has bgen implisated as the kost biologically wctivx becanse it is the predominant isomer incorpkrated inho bhe phospholi[ids of cell memyranes, liver phospholipids and triglycermdes (Kramer et al., 1998). This is the only isomer lncorporated into the phos[holipid fraction of cell membranes on animals fed a mixturs of CNA islmers (Ha et al., 1990
, specifically polyunsaturated fatty acids, are preferred nutrition they have positive effect on blood thus on the of heart disease. are used in a variety of foodstuffs or medicaments. Especially valuable and sought-after unsaturated fatty acids are the so-called unsaturated fatty acids, such as conjugated linoleic acid. A series of positive effects been for fatty thus, the administration of conjugated linoleic acid reduces body fat in humans and animals, and increases conversion of feed into body weight in the of animals (WO 94/16690, 96/06605, WO 97/46230, WO 97/46118). administering linoleic acid, is possible positively affect, for allergies (WO 97/32008) or cancer (Banni et al., Carcinogenesis, Vol. 20, 1999: 1019–1024, Thompson et al., Cancer, Vol. 57, Conjugated linoleic (=CLA) an of linoleic acid ruminants. CLA refers to a mixture geometric isomers of linoleic acid, involving double bonds positions 9 11, 10 and 12 or 11 13, and has gained considerable attention in recent because of the many beneficial effects attributed to the cis-9, trans-11 and trans-10, cis-12 isomers, These include anti-carcinogenic activity, activity, the ability reduce catabolic of stimulation, the to enhance growth promotion and the ability to reduce body fat and Banni, 1998 for review, and references therein). The isomers positionally at positions 7 9, 9 and 11; 10 12) (Ha et al., geometrically cis-trans, the isomers CLA, cis-9, trans-11-octadecadienoic acid been implicated as the most active because it is the phospholipids of cell membranes, liver phospholipids and (Kramer et al., 1998). This is the isomer incorporated into the phospholipid fraction of cell membranes of animals fed mixture of (Ha et al., 1990
, specifically polyunsaturatEd fatty aciDs, are PreFerReD in hUman Nutrition since THey hAve a positive effect on thE cholEsTErol LEvEl in tHe blood ANd THUs oN tHe PosSiBIlIty of HeaRt diseaSe. They are uSed In A variety of diETeTic foodstuFfs Or medicamentS.
EsPecialLy ValUAble aNd sOught-After uNSaturaTed fatty aCiDS are thE So-calleD COnJugaTed unsaturated fatTY aCIds, such as conjuGated lInOLeIC AciD. A sEries of posItIve efFEcts havE BeEN FOunD For conjugated Fatty acids; tHUs, tHe admiNiStrATion of ConjuGaTEd lInoleic acid ReduCes body faT in humANs and anIMals, and IncreaSes The ConvERsIoN of FeED inTO bOdy WEigHt in the cAsE oF animAls (Wo 94/16690, wo 96/06605, wo 97/46230, WO 97/46118). BY adMiniSteriNg conjugated lInoLeic ACid, It is aLso poSsibLe To posItivelY affeCt, For example, allerGies (wO 97/32008) or canceR (BaNnI et Al., carciNOgenesIs, VOl. 20, 1999: 1019–1024, THompson Et al., CanCEr, REs., vOL. 57, 1997: 5067–5072).
coNjugated linoleic acId (=cla) iS an interMediatE Of LiNOleic aciD mEtaBoliSM In rumInanTS. ClA refers To a mixTUrE oF positiOnAl and gEoMetRic IsomeRS of lInoleiC acid, invOlvinG Double bonds at pOSitions 9 and 11, 10 and 12 OR 11 aND 13, AnD Has gAinEd consideraBle aTTentIon iN ReCenT Years BecauSe OF tHE many beneficial effeCtS attriButed To the cis-9, trans-11 And trans-10, ciS-12 ISOmers, in pArtiCUlAR. These include aNti-caRcinogenic ACtivity, aNtiatHerogeniC activity, THE ability To rEduCe tHe cATAbOlic effects of IMMune StImulatiOn, tHe abiliTy tO enHanCe gRoWth promotIon and thE aBiLiTy To rEduce BOdy fat (MaRtIn aNd banNi, 1998 for REview, aNd refErenCeS tHEreIn). The isOMeRS Can dIfFeR posItiOnAlly (mAinlY At pOsitionS 7 and 9, 9 and 11; or 10 And 12) (hA et aL., 1987) aNd GeometrIcally (cis-cis, cIs-Trans, trans-CiS, trAns-traNS). of the indIvidual isomers of CLA, cis-9, tRAns-11-octaDecAdienOic aCid has beeN imPlicatEd aS The mosT bioloGicalLy ActIVE becaUSE iT is ThE predominaNT IsoMer inCoRporAted intO the phospholipids oF CelL membranes, livEr pHospHOLiPidS AnD TriGlYCerIDEs (Kramer et al., 1998). ThiS is the only IsOMeR incorporaTEd iNtO the phoSpholipId fraCTion of cEll membraNes of animAlS fed A MIxtUre of CLA isOmers (Ha eT al., 1990
, specifically polyunsatur ated fatty  acid s,are  p refe rred  in human nutr i tion  since they have a pos itive  e f fect on  thecholest e ro l lev el  i n t he bl ood a ndthus on  the possi bil it y of heart d i se ase. Theyare  used in a v ari ety of  d iet e tic f ood stuff s or m e dicame nts.
Espe ci a lly va l uable a n d  s ough t-after unsaturat e df atty acids are  the s o- c al l e d c onj ugated uns at urate d  fattya ci d s ,  su c h as conjugat ed linoleic aci d. A s er ies of pos itive  e f fec ts have bee n fo und for c onjuga t ed fatt y  acids;  thus,  th e a dmin i st ra tio no f c o nj uga t edlinoleic  a ci d red uces b o d y fa t i n hu mansand animals,and  inc r eas es th e con vers io n offeed i nto b od y weight in the  cas e of anim als  ( WO94 /1669 0 , WO 9 6/0 660 5, WO 9 7/46230 ,  WO  9 7 / 4 61 18). By administer in g co njugated  linol e ic  a c id, it i sals o po s s ibleto p o si tively a ffect, fo rexample ,allerg ie s ( WO97/32 0 08)or can cer (Ban ni et al., Carcinoge n esis, Vol. 20 ,  1 9 9 9: 1019 –10 24, Thompso n et al.,  Can c er , R e s., V ol. 5 7, 19 9 7: 5067–5072).
Conj ug ated l inole ic acid (=CLA ) is an in t e r mediateof l i no l eic acid metab olism  in rumina n ts. CLArefer s to a m ixture of p ositiona l a ndgeo met r i cisomers of li n o leic  a cid, in vol ving do ubl e b ond s a tpositions  9 and 1 1,  1 0an d 1 2 or1 1 and 13 ,and  h asgaine d  consi derab le a tt en t ion  in rec e nt y ears  b ec ause  of  t he ma ny b e nef icial e ffects at tri b uted  t othe cis -9, trans-11an d trans-10 ,cis -12 is o m ers, inparticular. These inclu d e anti- car cinog enic  activity , a ntiath ero g enic a ctivit y, th eabi l i ty to r ed uce  t he catabol i c  ef fects  o f im mune st imulation, the abi l ity  to enhance g row th p r o mo tio n  a n d t he abi l i ty to reduce bo dy fat (Ma rt i nand Banni, 199 8for rev iew, an d ref e rencestherein).  The isom er s ca n dif fer positi onally ( mainly at posit i on s 7 a nd9, 9 a nd  11 ; or10 and 12)  (Haet al. ,1987)and g eo metrical ly (cis-cis, cis-trans,  trans -cis,  tr ans-trans ).O f t he indivi dual  isomers o f C LA,  cis- 9,t rans- 11-o c ta dec a dieno ic a c id has be e nimp l i ca ted as them o s t b iolog ica l ly act ivebecause it is the predominant is omer i nco rpo r ated  i nto the phosph oli pi d s  of cell  m embranes, l iver pho sp h olipi ds and  trigl yceride s (K r amer e t al .,1998). Th isis the onl yis o mer in corp or ated i nto th e  pho s p holipid fraction  of c e l l mem b ran es of  a nimalsf ed a  mixture o f CLA isome rs (Ha  etal.,1990
, specifically_polyunsaturated fatty_acids, are preferred in_human nutrition_since_they have_a_positive effect on_the cholesterol level_in the blood and_thus on the_possibility_of heart disease. They are used in a variety of dietetic foodstuffs or medicaments.
Especially_valuable_and sought-after_unsaturated_fatty_acids are the so-called conjugated_unsaturated fatty acids, such as_conjugated linoleic_acid. A series of positive effects have been_found_for conjugated fatty_acids; thus, the administration of conjugated linoleic acid reduces_body fat in humans and animals,_and increases the_conversion_of_feed into body weight_in the case of animals (WO_94/16690, WO 96/06605, WO 97/46230, WO_97/46118). By administering conjugated linoleic acid, it_is also possible to positively affect,_for example, allergies (WO 97/32008)_or cancer_(Banni et al., Carcinogenesis, Vol._20, 1999: 1019–1024,_Thompson et_al., Cancer, Res.,_Vol. 57, 1997: 5067–5072).
Conjugated linoleic acid_(=CLA) is an_intermediate of linoleic acid metabolism in_ruminants._CLA refers to_a_mixture_of positional_and geometric isomers_of_linoleic acid,_involving_double bonds at positions 9 and_11,_10 and 12 or 11 and 13,_and has gained considerable_attention_in recent years because_of the many beneficial effects_attributed to the cis-9, trans-11 and_trans-10, cis-12_isomers, in_particular. These include anti-carcinogenic activity, antiatherogenic activity, the ability to reduce_the catabolic effects of immune stimulation,_the ability to enhance_growth promotion_and_the ability to_reduce_body fat_(Martin and Banni, 1998 for review, and_references therein)._The isomers can differ positionally (mainly_at positions 7 and_9,_9 and 11; or 10 and_12) (Ha et al., 1987) and_geometrically (cis-cis, cis-trans, trans-cis, trans-trans)._Of_the_individual isomers of CLA, cis-9,_trans-11-octadecadienoic acid has been implicated as_the most biologically_active because it is the predominant isomer_incorporated_into the phospholipids of cell membranes,_liver_phospholipids and triglycerides (Kramer et al.,_1998)._This_is the only isomer incorporated_into the phospholipid fraction of cell_membranes of animals fed a mixture of CLA isomers_(Ha et al.,_1990