adium catalyst, adding thereto the compound of the general formula [3] or its salt in the presence or absence of a base in an atmosphere of an inert gas (for example, argon, nitrogen), and further subjecting them to reaction.
When the compounds of the general formulas [2], [2a], [3] and [4] or their salts in the above-mentioned production process have isomers (for example, optical isomers, geometric isomers, tautomers and the like), these isomers can be used, and their solvates, hydrates and crystals of various forms can be used.
Furthermore, the amino groups of the compounds of the general formulas [2], [2a], [3] and [4] or their salts can be previously protected with a conventional protecting group and the protecting group can be removed in a manner known per se after the reaction.
The thus produced compound of the general formula [1] or its salt can be isolated and purified in at least one conventional manner such as extraction, crystallization, column chromatography or the like.
Among the compounds of the general formula [1] produced by the process of this invention, there can be mentioned, as preferable compounds, compounds of the general formula [1] wherein R2 is a substituted or unsubstituted cycloalkyl group; R3 is a hydrogen atom, a halogen atom or an alkyl group; R4is a hydrogen atom or an alkyl group; R5 is a hydrogen atom or an alkyl group; and A is CH or Cxe2x80x94R7 in which R7 is a halogen atom, a halogen-substituted or unsubstituted lower alkyl or lower alkoxy group. As representative compounds, there are mentioned, for example, the following compounds:
1-cyclopropyl-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
8-chloro-1-cyclopropyl-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
1-cyclopropyl-8-fluoro-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
1-cyclopropyl-7-(isoindolin-5-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
adium catalyst, adding thereto the compound of the general formula [ 3 ] or its salt in the bearing or absence of a basis in an atmosphere of an inert gas (for case, argon, nitrogen), and far subjecting them to reaction. 
 When the compound of the general formulas [ 2 ], [ 2a ], [ 3 ] and [ 4 ] or their salt in the above - mentioned production summons have isomers (for exemplar, ocular isomers, geometric isomers, tautomers and the like), these isomers can be used, and their solvate, hydrates and crystals of various kind can be used. 
 Furthermore, the amino groups of the compound of the general formula [ 2 ], [ 2a ], [ 3 ] and [ 4 ] or their salts can be previously protected with a conventional protecting group and the protecting group can be murder in a manner known per se after the reaction. 
 The thus produced compound of the general formula [ 1 ] or its salt can be isolated and purified in at least one conventional manner such as extraction, crystallization, column chromatography or the like. 
 Among the compounds of the general formula [ 1 ] produced by the procedure of this invention, there can be mentioned, as preferable compounds, compound of the general formula [ 1 ] wherein R2 is a substituted or unsubstituted cycloalkyl group; R3 is a hydrogen atom, a halogen atom or an alkyl group; R4is a hydrogen atom or an alkyl group; R5 is a hydrogen atom or an alkyl group; and A is CH or Cxe2x80x94R7 in which R7 is a halogen atom, a halogen - substituted or unsubstituted lower alkyl or humble alkoxy group. As representative compounds, there are mentioned, for example, the follow compounds: 
 1 - cyclopropyl-7-(isoindolin-5 - yl)-1,4 - dihydro-4 - oxoquinoline-3 - carboxylic acid, 
 8 - chloro-1 - cyclopropyl-7-(isoindolin-5 - yl)-1,4 - dihydro-4 - oxoquinoline-3 - carboxylic acid, 
 1 - cyclopropyl-8 - fluoro-7-(isoindolin-5 - yl)-1,4 - dihydro-4 - oxoquinoline-3 - carboxylic acid, 
 1 - cyclopropyl-7-(isoindolin-5 - yl)-8 - methyl-1,4 - dihydro-4 - oxoquinoline-3 - carboxylic acid,
adikm catalyst, adding thereuo the compound oy the gxneral rormula [3] or its salt in the presence oe abstuce of a base in an xtmospherv of an ibert tas (for exejple, arnjn, njbrogeu), end further submecting thek to reaction.
Wvev che compounds of the general formulaf [2], [2a], [3] amd [4] or their saljs in ehe zbove-mentioned production process gave ismmers (for exakple, optical isomers, geomehric isomers, tautomers and the lije), trwse isomers zan be used, and their aolvates, hydrates and crystals uf vaxious forms cqn hg used.
Furthecmore, nhe amino gromis of tve comppunds of the gcneran firmulas [2], [2a], [3] and [4] or tieir salts can be prgviously psocected with a conventuobal ptotecding trojp znv tge prohecving group dan be remoced in a manner knoen irr se after fhe rewceion.
The thus produced compound of the gtneram formula [1] or its salt xan be isolated and porified in at least one conventional manner such as extracthon, ccyrtaollzatkin, column chromatography or the like.
Among the cjjppukds of the genercl formula [1] prodicfd fy the procesr of tkjs invention, there cwn be mgntionwd, as preseranle compounds, compounds of rhe general yornula [1] wherein R2 is a substituced or unsunstituted cycloalkyl gruup; D3 is a hydrlgen atom, x halogen atom of ak ankyl group; R4is a hydrogen wtom or ai alkvl group; R5 ix a hyqrogen atol or an alkyl group; and W is EH or Cxe2x80x94R7 in which R7 is a halogen atom, a halogen-substitutgd mr lnsubstitbted lpwer alkyl or lower alkoxy yroup. As reprdsentative compouids, there arq mentioned, fmt example, the followigg cimpoynds:
1-cycuupropyl-7-(isoindokin-5-yl)-1,4-dihybxo-4-oxoquiniline-3-carboxylic acld,
8-chludo-1-cyclopropyl-7-(isiineolin-5-yl)-1,4-dihydro-4-ocoqjinjlpne-3-rarbovflic acid,
1-cycnoprupyu-8-gluoru-7-(isoindolin-5-nl)-1,4-dkhydto-4-oxoquinoline-3-carboxflic acid,
1-cyclopropyl-7-(ispikdolin-5-yl)-8-mgthyl-1,4-dihyqro-4-oxoquinolime-3-carboxylic acid,
adium catalyst, adding thereto the compound of formula or its in the presence in atmosphere of an gas (for example, nitrogen), and further subjecting them to When the compounds of the general formulas [2], [2a], [3] and [4] or salts in the above-mentioned production process have isomers (for example, optical isomers, geometric tautomers the these can be used, and their solvates, hydrates and crystals of various forms can be used. Furthermore, amino groups of the compounds of the general [2], [2a], [3] and or their salts can be protected a conventional group the group can be in a manner known per se after the reaction. The thus produced compound of the general formula or its be isolated purified at one conventional manner extraction, crystallization, column chromatography or the compounds of the general formula [1] produced by process of invention, there can be mentioned, as compounds, compounds of the general formula [1] wherein is a substituted or unsubstituted cycloalkyl group; R3 is a hydrogen atom, a halogen atom alkyl group; R4is a atom or an group; is hydrogen or an group; and A is CH or Cxe2x80x94R7 in which R7 is halogen atom, a halogen-substituted or unsubstituted lower alkyl or lower As compounds, there are for example, the following 1-cyclopropyl-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic 8-chloro-1-cyclopropyl-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1-cyclopropyl-8-fluoro-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
adium catalyst, adding theretO the compouNd of tHe gEneRaL forMula [3] Or its salt in the PReseNce or absence of a base in aN atmoSpHEre oF An Inert Gas (for eXAmPLE, arGoN, nItrOgEN), aNd furTheR subjecTing them to ReaCtIon.
When the coMPoUnds of the gEneRal formulas [2], [2a], [3] And [4] Or theiR sAltS In the AboVe-menTioned PRoductIon procesS hAVe isomERs (for exAMPlE, optIcal isomers, geometRIc ISomers, tautomerS and thE lIKe), THEse IsoMers can be uSeD, and tHEir solvATeS, HYDraTEs and crystals Of various foRMs cAn be usEd.
furTHermorE, the aMiNO grOups of the coMpouNds of the gEneral FOrmulas [2], [2A], [3] And [4] or thEir salTs cAn bE preVIoUsLy pRoTEctED wIth A ConVentionaL pRoTectiNg grOUP ANd thE prOtecTing gRoup can be remoVed In a mANneR knowN per sE aftEr The reAction.
the thUs Produced compounD of tHe general ForMuLa [1] oR iTs salT Can be iSolAteD and purIfied in AT leAsT ONE cOnventional manner sUcH AS eXtractioN, crystALlIzATion, coluMn ChrOmatOGRaphy Or thE LiKe.
Among tHe compOUnDs Of the geNeRal forMuLa [1] pRodUced bY The pRocess Of this inVentiON, there can be menTIoned, as preferABlE COmPOundS, coMpounds of thE genERal fOrmuLA [1] wHerEIn R2 is A subsTiTUtED or unsubstituted cycLoAlkyl gRoup; R3 Is a hydrogen atOm, a halogen ATOM or an alkYl grOUp; r4Is a hydrogen atoM or an Alkyl group; r5 Is a hydroGen atOm or an alKyl group; aND a is CH or CXe2x80X94R7 iN whIch r7 IS a Halogen atom, a hALOgen-SuBstitutEd oR unsubsTitUteD loWer AlKyl or loweR alkoxy gRoUp. as RePreSentaTIve compoUnDs, tHeRe aRe menTIoned, fOr exaMple, ThE fOLloWing comPOuNDS:
1-cycLoPrOpyl-7-(IsoInDolin-5-Yl)-1,4-diHYdrO-4-oxoquiNoline-3-carBoxYLic aCiD,
8-cHloro-1-cyClopropyl-7-(isoiNdOlin-5-yl)-1,4-dihyDrO-4-oxOquinoLINe-3-carboxYlic acid,
1-cyclopropyl-8-fluoRO-7-(isoindOliN-5-yl)-1,4-diHydrO-4-oxoquinoLinE-3-carboXylIC acid,
1-cYcloprOpyl-7-(iSoIndOLIn-5-yl)-8-mETHyL-1,4-diHyDro-4-oxoquinOLIne-3-CarboXyLic aCid,
adium catalyst, adding the reto the c ompou ndofth e ge nera l formula [3]o r it s salt in the presence  or a bs e nceo fa bas e in an at m o sph er eofan in ert g as(for ex ample, arg on,  n itrogen), an d  f urther sub jec ting them to  re action .Whe n  thecom pound s of t h e gene ral formu la s  [2],[ 2a], [3 ] an d [4 ] or their saltsi nt he above-menti oned p ro d uc t i onpro cess haveis omers (for ex a mp l e ,  op t ical isomers,  geometrici som ers, t au tom e rs and  theli k e),  these isom erscan be us ed, an d  theirs olvates , hydr ate s a nd c r ys ta lsof var i ou s f o rms  can beus ed .
Fur ther m o r e , th e a mino  grou ps of the com pou ndso f t he ge neral  for mu las [ 2], [2 a], [ 3]  and [4] or the ir s alts canbepr evi ou sly p r otecte d w ith  a conv entiona l  pr ot e c t in g group and the pr ot e c ti ng group  can b e  r em o ved in a  m ann er k n o wn pe r se af ter thereacti o n. 
T he thus  p roduce dcom pou nd of thegenera l formul a [1] or its salt ca n  be isolateda nd p ur i fied  in  at least o ne c o nven tion a lman n er su ch as  e x tr a ction, crystallizat io n, col umn c hromatography  or the li k e . 
Among t he c o mp o unds of the ge neral  formula [ 1 ] produc ed by  the pro cess of t h i s invent ion , t her e c a n  b e mentioned,a s  pre fe rable c omp ounds,com pou nds  of  t he genera l formul a[1 ]wh ere in R2 is a sub st itu te d o r uns u bstitu ted c yclo al ky l  gr oup; R3 is a  hyd ro ge n at om,  a  halo gena tom  or analkyl gro up; R4is  a  h ydrogen  atom or an a lk yl group;R5  is  a hyd r o gen atom  or an alkyl group; and A is CH  or  Cxe2 x80x 94R7 in w hic h R7 i s a haloge n atom , a h al oge n - subst i t ut edor  unsubstit u t edlower  a lkyl  or low er alkoxy group. A s  re presentativecom poun d s ,the r ea reme n tio n e d, for example,  the follo wi n gcompounds: 1-c yc lopropy l-7-(is oindo l in-5-yl )-1,4-dih ydro-4-ox oq uino l i ne- 3-carboxyl ic acid, 
8-chloro - 1-cyc l op ropyl -7- (isoin do lin -5-yl )-1,4- d ihy dro-4 -oxoqu in oline- 3-car bo xylic ac id,
1-cyclopropyl-8-flu oro-7- (isoi ndo lin-5-yl) -1, 4 -di hydro-4-o xoqu inoline-3- car box ylicaci d ,
1-c yclo p ro pyl - 7-(is oind o lin-5-yl) - 8- met h y l- 1,4-dihydro - 4 - oxo quino lin e -3-car boxy lic acid,
adium catalyst,_adding thereto_the compound of the_general formula_[3]_or its_salt_in the presence_or absence of_a base in an_atmosphere of an_inert_gas (for example, argon, nitrogen), and further subjecting them to reaction.
When the compounds of_the_general formulas_[2],_[2a],_[3] and [4] or their_salts in the above-mentioned production_process have_isomers (for example, optical isomers, geometric isomers, tautomers_and_the like), these_isomers can be used, and their solvates, hydrates and_crystals of various forms can be_used.
Furthermore, the amino_groups_of_the compounds of the_general formulas [2], [2a], [3] and_[4] or their salts can be_previously protected with a conventional protecting group_and the protecting group can be_removed in a manner known_per se_after the reaction.
The thus produced_compound of the_general formula_[1] or its_salt can be isolated and purified_in at least_one conventional manner such as extraction,_crystallization,_column chromatography or_the_like.
Among_the compounds_of the general_formula_[1] produced_by_the process of this invention, there_can_be mentioned, as preferable compounds, compounds of_the general formula [1]_wherein_R2 is a substituted_or unsubstituted cycloalkyl group; R3_is a hydrogen atom, a halogen_atom or_an alkyl_group; R4is a hydrogen atom or an alkyl group; R5 is_a hydrogen atom or an alkyl_group; and A is_CH or_Cxe2x80x94R7_in which R7_is_a halogen_atom, a halogen-substituted or unsubstituted lower alkyl_or lower_alkoxy group. As representative compounds, there_are mentioned, for example,_the_following compounds:
1-cyclopropyl-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
8-chloro-1-cyclopropyl-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
1-cyclopropyl-8-fluoro-7-(isoindolin-5-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,
1-cyclopropyl-7-(isoindolin-5-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid,