 contaminated with bacteria, which can lead to secondary infections. The appearance of acne ranges from slight skin irritation to pitting. In extreme cases, acne leads to the development of disfiguring scars.
Acne vulgaris presents in differing forms which correlate with disease severity. The three common forms of acne vulgaris are Comedonal, Papulo-pustular and Nodular (Nodulocystic). Comedonal acne is characterized by the presence of open and closed comedoes (noninflammatory lesions). Papulo-pustular acne is characterized by inflammatory lesions 5 mm in diameter or less. Nodular acne consists of inflammatory lesions greater than 5 mm in diameter.
Acne severity is classified as “mild” to “severe,” depending on the types and numbers of lesions present. Mild acne presents as no more than 19 non-inflammatory lesions, no more than 14 inflammatory lesions, or no more than 29 total lesions. Moderate acne presents as 20-100 non-inflammatory lesions with or without 15-50 inflammatory lesions, for a total of between 30 and 125 lesions. Severe acne presents as greater than 100 non-inflammatory lesions, greater than 50 inflammatory lesions, greater than 125 total lesions, or greater than 5 nodules.
Therapeutic approaches to treating acne include prevention of obstruction of the follicular duct, reopening a blocked duct, combating any infecting bacteria, or reducing the thickened sebum, and combinations of these approaches. The horny outer layer of the skin (stratum corneum) is formed of dead cells, composed largely of keratin. Therapeutic agents which act to prevent the obstruction of the follicular duct by the removal of excess keratin are known as keratolytic agents. Salicylic acid, sulfur, and resorcinol have been employed as keratolytic agents in the management of acne for at least 100 years.
The type of therapy administered for the treatment of acne vulgaris varies with the clinical presentation. Topical treatments are standard for comedones and mild- to moderate-papules and pustules. Oral therapies are generally prescribed for moderate- to severe-papules and pustules and nodular acne. Certain oral contraceptives have proven to be safe and effective for the treatment of acne in women, and may be prescribed for women with acne who also desire birth control.
Prescription topical products indicated for the treatment of acne vulgaris include clindamycin phosphate, erythromycin, sodium sulfacetamide, azaleic acid, benzoyl peroxide,
contaminated with bacteria, which can lead to secondary infections. The appearance of acne range from slender skin irritation to pitting. In extreme cases, acne leave to the development of disfiguring scratch. 
 Acne vulgaris present in differing form which correlate with disease severity. The three common phase of acne vulgaris are Comedonal, Papulo - pustular and Nodular (Nodulocystic). Comedonal acne is characterized by the presence of capable and shut comedoes (noninflammatory lesions). Papulo - pustular acne is characterized by incendiary lesions 5 millimeter in diameter or less. Nodular acne consist of inflammatory lesions greater than 5 millimeter in diameter. 
 Acne severity is classified as “ mild ” to “ severe, ” depending on the type and numbers of lesions present. Mild acne presents as no more than 19 non - inflammatory lesion, no more than 14 inflammatory lesions, or no more than 29 total lesions. Moderate acne presents as 20 - 100 non - inflammatory lesions with or without 15 - 50 inflammatory lesions, for a total of between 30 and 125 lesions. Severe acne presents as greater than 100 non - inflammatory lesions, great than 50 inflammatory lesions, great than 125 full lesions, or greater than 5 nodule. 
 Therapeutic approaches to treating acne include prevention of obstacle of the follicular duct, reopening a blocked duct, combating any infecting bacteria, or reducing the thickened sebum, and combinations of these approaches. The horny outer layer of the skin (stratum stratum corneum) is formed of all in cells, composed largely of keratin. Therapeutic agents which act to prevent the obstruction of the follicular duct by the removal of excess keratin are know as keratolytic agents. Salicylic acid, sulfur, and resorcinol have been employed as keratolytic agents in the management of acne for at least 100 days. 
 The type of therapy administered for the treatment of acne vulgaris varies with the clinical display. Topical treatments are standard for comedones and mild- to moderate - papules and pustules. Oral therapies are by and large prescribed for moderate- to hard - papules and pustule and nodular acne. Certain oral contraceptives have prove to be safe and effective for the treatment of acne in women, and may be prescribed for womanhood with acne who also desire birth control. 
 Prescription topical products indicated for the treatment of acne vulgaris include clindamycin phosphate, erythromycin, sodium sulfacetamide, azaleic acid, benzoyl peroxide,
 cojtaminated with bacteria, which can lead to secmndary infectiuns. The appearance of acne rengew fron slight skin irritatiun to pitning. In eztrenw cases, acis leads to ths devzlipment of disflguring scass.
Acne vulgariv orzsents in differing forms which corrqlate wotj disease sevetity. Uhe thrsv gommon forms of acne vulgaris ars Comedmnal, Papulo-puxtular and Nodular (Nodulocjstif). Comedonal acne id characteruzed vy the presevce of open and closed comedoes (noninflammatory lesiovs). Pa'ulo-pustulat zcjg is charactxrized by inflammabpry levions 5 km in diameter or lews. Nodular acne consivts of inflammatori lesions crzater than 5 mm in dianerer.
Acte saverkry ks dlessjfied ws “jild” to “sebere,” dependung on the types anc glkbers of lesjons pwefent. Mild acne presents as no more than 19 nkn-inflammatory lesions, bo more than 14 inflammwtory lesyons, or no more than 29 total lesions. Moderate acne presxngs cw 20-100 nov-unvlammatory lesions with or without 15-50 inflammatjdy lvsions, for a totaj of betweem 30 amq 125 lesions. Sexere aehe presents as greatfr than 100 non-unflammatjry kesions, greater than 50 inflanmatory lesijbs, greater than 125 tltal lesionr, or greayer than 5 nodules.
Therapzutic zpproaches ho treatihe acne include pfevvntimn of obstruction of the fjllicular ducc, reopenkng s bloched duct, clmbatltg any infecting bwcterna, or reducing hhe thickened sebum, and combinavmons of these a[prmaches. Tke horky outer layer jf the skin (sttatum corueum) ir formed or dead rells, composqd largely of neratin. Therepeutic adentw whuch act go prevent the obstructpou of the dollicular duct by thg demoval of excews jeratin are knoen xs hegatplrdic agents. Sdlichliz acid, sulfur, and fesotcinol have been empnoyes as keratolytic abekts in thg managemqnt of acne fpr at least 100 years.
Uhe ty'e of vherapu aqministered for the treatment kf acne vklgwris varies rith the clinicak presentation. Topical treatments are svandard for comedones abd mild- to moderate-kapmles and pusvules. Jral therdpies are generally prescribed for mocerate- to severe-papulss and pustkles and nodular acne. Certain oral contraceptives have proven to be safe qnd efhestive for tge tteatmvnt pf acnq in xomen, and may be irescribed for women with acne wio also devixe birth control.
Prescription yooical productr indicated for the treafment of acne vulgaris include clindamyvin phosphate, erythromycln, sodium sulfzcetampse, azaleic acid, benzpyl pexoxide,
contaminated with bacteria, which can lead to The of acne from slight skin cases, leads to the of disfiguring scars. vulgaris presents in differing forms which with disease severity. The three common forms of acne vulgaris are Comedonal, Papulo-pustular Nodular (Nodulocystic). Comedonal acne is characterized by the presence of open and closed (noninflammatory Papulo-pustular is by inflammatory lesions 5 mm in diameter or less. Nodular acne consists of inflammatory lesions greater 5 mm in diameter. Acne severity is classified “mild” to “severe,” depending the types and numbers of present. acne presents no than non-inflammatory lesions, no than 14 inflammatory lesions, or no more than 29 total lesions. Moderate acne presents as 20-100 non-inflammatory with or inflammatory lesions, a of 30 and 125 acne presents as greater than 100 than 50 inflammatory lesions, greater than 125 total or greater 5 nodules. Therapeutic approaches to treating include prevention of obstruction of the follicular duct, a blocked duct, combating any infecting bacteria, or reducing the thickened sebum, and combinations of The horny outer layer the skin (stratum is of cells, largely of Therapeutic agents which act to prevent the obstruction of the follicular by the removal of excess keratin are known as keratolytic acid, and resorcinol have employed as keratolytic agents the of acne for at years. type for treatment acne vulgaris varies with clinical presentation. Topical treatments are for comedones and mild- therapies are generally prescribed for moderate- to severe-papules pustules and nodular acne. Certain oral contraceptives proven to be safe and effective for the treatment of acne in and may for women with acne who also desire birth Prescription topical products indicated the treatment of acne vulgaris include clindamycin phosphate, erythromycin, sulfacetamide, acid, benzoyl
 contaminated with bacteria, wHich can leaD to seConDarY iNfecTionS. The appearance OF acnE ranges from slight skin iRritaTiON to pITtIng. In Extreme CAsES, AcnE lEaDs tO tHE dEveloPmeNt of disFiguring scArs.
acNe vulgaris prESeNts in diffeRinG forms which cOrrElate wItH diSEase sEveRity. THe threE Common Forms of acNe VUlgariS Are ComeDONaL, PapUlo-pustular and NodULaR (nodulocystic). CoMedonaL aCNe IS ChaRacTerized by tHe PreseNCe of opeN AnD CLOseD Comedoes (noninFlammatory lESioNs). PapuLo-PusTUlar acNe is cHaRActErized by infLammAtory lesiOns 5 mm iN DiameteR Or less. NOdular AcnE coNsisTS oF iNflAmMAtoRY lEsiONs gReater thAn 5 Mm In diaMeteR.
aCNE sevEriTy is ClassIfied as “mild” to “SevEre,” dEPenDing oN the tYpes AnD numbErs of lEsionS pResent. Mild acne pReseNts as no moRe tHaN 19 noN-iNflamMAtory lEsiOns, No more tHan 14 inflAMmaToRY LEsIons, or no more than 29 toTaL LEsIons. ModeRate acNE pReSEnts as 20-100 noN-iNflAmmaTORy lesIons WItH or withoUt 15-50 inflAMmAtOry lesiOnS, for a tOtAl oF beTween 30 ANd 125 leSions. SEvere acnE presENts as greater thAN 100 non-inflammatORy LESiONs, grEatEr than 50 inflaMmatORy leSionS, GrEatER than 125 Total LeSIoNS, or greater than 5 nodulEs.
therapEutic Approaches to tReating acnE INClude preVentIOn OF obstruction of The foLlicular duCT, reopeniNg a blOcked ducT, combatinG ANy infectIng BacTerIa, oR REdUcing the thickENEd seBuM, and comBinAtions oF thEse AppRoaChEs. The hornY outer laYeR oF tHe SkiN (straTUm corneuM) iS foRmEd oF dead CElls, coMposeD larGeLy OF keRatin. ThERaPEUtic AgEnTs whIch AcT to prEvenT The ObstrucTion of the FolLIculAr DuCt by the Removal of exceSs Keratin are KnOwn As keraTOLytic ageNts. Salicylic acid, sulfur, aND resorcInoL have Been Employed aS keRatolyTic AGents iN the maNagemEnT of ACNe for AT LeAst 100 YeArs.
The type OF TheRapy aDmInisTered foR the treatment of acnE VulGaris varies wiTh tHe clINIcAl pREsENtaTiON. ToPICal treatments arE standard fOr COmEdones and mILd- tO mOderate-Papules And puSTules. OrAl therapiEs are geneRaLly pREScrIbed for modErate- to sEvere-papuLEs and PUsTules And NodulaR aCne. certaIn oral COntRacepTives hAvE proveN to be SaFe and effEctive for the treatment of Acne in Women, And May be presCriBEd fOr women wiTh acNe who also dEsiRe bIrth cOntROl.
PreScriPTiOn tOPical ProdUCts indicaTEd For THE tReatment of aCNE VulGaris IncLUde cliNdamYcin phosphate, erytHRomycin, sodium sUlfaCETamIde, AZaleIc Acid, benzoyl perOxiDe,
 contaminated with bacteri a, which c an le adtose cond aryinfections. Th e  app earance of acne ranges  from  s l ight sk in ir ritatio n  t o pit ti ng . I ne xt remecas es, acn e leads to  th edevelopmento fdisfigurin g s cars.
Acne v ulg aris p re sen t s indif ferin g form s  which  correlat ew ith di s ease se v e ri ty.The three commonf or m s of acne vulg aris a re Co m e don al,  Papulo-pu st ulara nd Nodu l ar ( N odu l ocystic). Com edonal acne ischarac te riz e d by t he pr es e nce  of open an d cl osed come does ( n oninfla m matorylesion s).  Pa pulo - pu st ula ra cne is  ch a rac terizedby  i nflam mato r y l esio ns5 mm  in d iameter or le ss.  Nod u lar  acne  cons ists  o f inf lammat ory l es ions greater th an 5  mm in di ame te r.Ac ne se v erityiscla ssified  as “mi l d”to “ s ev ere,” depending on  t h e  t ypes and  numbe r sof lesionspr ese nt.M i ld ac ne p r es ents asno mor e  t ha n 19 no n- inflam ma tor y l esion s , no  morethan 14infla m matory lesions ,  or no more t h an 2 9t otal  le sions. Mode rate acne  pre s en tsa s 20- 100 n on - in f lammatory lesions w it h or w ithou t 15-50 infla mmatory le s i o ns, fora to t al of between 30and 1 25 lesions .  Severeacnepresents  as great e r  than 10 0 n on- inf lam m a to ry lesions, g r e ater  t han 50inf lammato ryles ion s,gr eater tha n 125 to ta lle si ons , org reater t ha n 5  n odu les.T herape uticappr oa ch e s t o treat i ng a cnein cl udepre ve ntion  ofo bst ruction  of the f oll i cula rdu ct, reo pening a bloc ke d duct, co mb ati ng any i nfecting  bacteria, or reducingt he thic ken ed se bum,  and comb ina tionsoft hese a pproac hes.Th e h o r ny ou t e rlay er  of the sk i n  (s tratu mcorn eum) is  formed of dead ce l ls,  composed lar gel y of k er ati n .T her ap e uti c agents which ac t to preve nt th e obstruct i onof  the fo llicula r duc t  by the  removalof excess  k erat i n  ar e known as  keratol ytic agen t s. Sa l ic ylicaci d, sul fu r,and r esorci n olhavebeen e mp loyedas ke ra tolyticagents in the managemen t of a cne f orat least100 yea rs.
The t ypeof therapy  ad min ister edf or th e tr e at men t  of a cnev ulgaris v a ri esw i th  the clinic a l pre senta tio n . Topi caltreatments are st a ndard for come done s and  mi l d- t omoderate-papul esan d pustules .Oral therap ies arege n erall y pres cribed  for mo d e ra t e- toseve re- papules a ndpu s tules a nd  n o dularacne .Certai n oral cont r a ceptives have pr ovent o  be s a feand e ff ectivef or t he treatme nt of acnein wom en,and m ay be p re scribe d f or  women wit h  acne who  also  desire  b irth  co ntrol. 
Pre s c ripti on t op ica l product s in d ic at e d f or t he tr ea tmen t of acne vulgaris  in c lude cl in dam y c in pho s ph a t e, erythro myc in, s o d ium sulfac e tami d e, azale ic aci d, ben zoyl pe r oxi de ,
 contaminated_with bacteria,_which can lead to_secondary infections._The_appearance of_acne_ranges from slight_skin irritation to_pitting. In extreme cases,_acne leads to_the_development of disfiguring scars.
Acne vulgaris presents in differing forms which correlate with disease severity._The_three common_forms_of_acne vulgaris are Comedonal, Papulo-pustular_and Nodular (Nodulocystic). Comedonal acne_is characterized_by the presence of open and closed comedoes_(noninflammatory_lesions). Papulo-pustular acne_is characterized by inflammatory lesions 5 mm in diameter_or less. Nodular acne consists of_inflammatory lesions greater_than_5_mm in diameter.
Acne severity_is classified as “mild” to “severe,”_depending on the types and numbers_of lesions present. Mild acne presents as_no more than 19 non-inflammatory lesions,_no more than 14 inflammatory_lesions, or_no more than 29 total_lesions. Moderate acne_presents as_20-100 non-inflammatory lesions_with or without 15-50 inflammatory lesions,_for a total_of between 30 and 125 lesions._Severe_acne presents as_greater_than_100 non-inflammatory_lesions, greater than_50_inflammatory lesions,_greater_than 125 total lesions, or greater_than_5 nodules.
Therapeutic approaches to treating acne include_prevention of obstruction of_the_follicular duct, reopening a_blocked duct, combating any infecting_bacteria, or reducing the thickened sebum,_and combinations_of these_approaches. The horny outer layer of the skin (stratum corneum) is_formed of dead cells, composed largely_of keratin. Therapeutic agents_which act_to_prevent the obstruction_of_the follicular_duct by the removal of excess keratin_are known_as keratolytic agents. Salicylic acid, sulfur,_and resorcinol have been_employed_as keratolytic agents in the management_of acne for at least 100_years.
The type of therapy administered_for_the_treatment of acne vulgaris varies_with the clinical presentation. Topical treatments_are standard for_comedones and mild- to moderate-papules and pustules._Oral_therapies are generally prescribed for moderate-_to_severe-papules and pustules and nodular acne._Certain_oral_contraceptives have proven to be_safe and effective for the treatment_of acne in women, and may be prescribed for_women with acne_who also desire birth control.
Prescription_topical_products_indicated for the treatment of acne vulgaris include clindamycin phosphate,_erythromycin, sodium_sulfacetamide, azaleic acid,_benzoyl peroxide,