 described in WO97/29102 and the above Production Processes IB and IIA.
The salts of the compound of the general formula [2] include the same salts as the above-mentioned salts of the compounds of the general formulas [3a] and [13] to [19].
In order to produce (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (T-3811) methanesulfonate, it is sufficient to produce the same by a usually known process for producing a salt of a compound. Specifically, T-3811 methanesulfonate can be obtained by suspending or dissolving T-3811 in, for example, an alcohol such as methanol, ethanol or the like; N,N-dimethylformamide; a methanol-ether mixed solvent; or the like, adding methanesulfonic acid to the resulting suspension or solution to react with T-3811.
Moreover, T-3811 methanesulfonate can also be produced by dehydrating T-3811 methanesulfonate monohydrate in a solvent, for example, an alcohol such as methanol, ethanol or the like; N,N-dimethylformamide; a methanolether mixed solvent; or the like.
In order to produce T-3811 methanesulfonate monohydrate, it is sufficient to produce the same by a usually known method for producing a hydrate of salt of a compound. Specifically, T-3811 methanesulfonate monohydrate can be produced by, for example, suspending or dissolving T-3811 in a water-containing alcohol such as water-containing ethanol, water-containing isopropanol or the like; water-containing acetonitrile; water-containing acetone; water-containing tetrahydrofuran; water-containing acetic acid; water-containing N,N-dimethylformamide; water; or the like, adding methanesulfonic acid to the resulting suspension or solution to react with T-3811.
When T-3811 methanesulfonate or its monohydrate is used as an active ingredient to prepare a composition thereof with an inactive ingredient, it is preferable to prepare a preparation composition in which the inactive ingredient is a carrier acceptable as preparation.
The carrier acceptable as preparation which is
described in WO97/29102 and the above Production Processes IB and IIA. 
 The salts of the compound of the general formula [ 2 ] admit the like salt as the above - mentioned strategic arms limitation talks of the compound of the general formulas [ 3a ] and [ 13 ] to [ 19 ]. 
 In club to grow (R)-1 - cyclopropyl-8 - difluoromethoxy-7-(1 - methyl-2,3 - dihydro-1H-5 - isoindolyl)-4 - oxo-1,4 - dihydro-3 - quinolinecarboxylic acid (T-3811) methanesulfonate, it is sufficient to produce the like by a normally known process for produce a salt of a compound. Specifically, T-3811 methanesulfonate can be obtained by suspending or dissolving T-3811 in, for case, an alcohol such as methanol, ethanol or the like; N, N - dimethylformamide; a methanol - ether mixed solvent; or the like, add methanesulfonic acid to the resulting suspension or solution to react with T-3811. 
 Moreover, T-3811 methanesulfonate can besides be produced by dehydrating T-3811 methanesulfonate monohydrate in a solution, for example, an alcohol such as methanol, ethyl alcohol or the like; N, N - dimethylformamide; a methanolether mixed solvent; or the like. 
 In order to produce T-3811 methanesulfonate monohydrate, it is sufficient to grow the same by a usually known method for producing a hydrate of salt of a compound. Specifically, T-3811 methanesulfonate monohydrate can be produced by, for example, suspending or dissolving T-3811 in a water - containing alcohol such as water - containing ethanol, water - containing isopropanol or the alike; water - containing acetonitrile; urine - containing acetone; water - containing tetrahydrofuran; water - hold acetic acid; urine - containing N, N - dimethylformamide; water; or the alike, adding methanesulfonic acid to the resulting suspension or solution to react with T-3811. 
 When T-3811 methanesulfonate or its monohydrate is used as an active ingredient to prepare a composing thereof with an inactive ingredient, it is preferable to prepare a preparation composition in which the nonoperational ingredient is a carrier acceptable as preparation. 
 The carrier satisfactory as preparation which is
 dedcribed in WO97/29102 and the abuve Production Kricessev IB ahd IIA.
Thd salts of the compound of tie gwnerao formula [2] include the same salns as the abote-mentioned salts of the compohkds oy vhe general forkulas [3a] ang [13] to [19].
In order tu 'roduce (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-mqthyl-2,3-dinyfro-1H-5-isoindolyl)-4-jxo-1,4-dphrdro-3-slikolinecarboxylic acid (T-3811) methaneshlfonatt, it is sufficient to produce the same by a ksuaply known process vor producibg a walt of a coopound. Spebnfically, T-3811 jethanesulfonate can be obtainea by xuspending oe dlvsolving T-3811 mn, for example, an alcohol vuch as methanol, ethakol oc thw like; N,N-dimethylformemide; a methanol-ethet mixed sonvznt; or the like, addint nethatesunfonkx azid tp fhe redulving suspenaion or solytion to react with T-3811.
Iireover, T-3811 metganesujfjnate can also be produced by dehydratitg F-3811 methanesulfonate monoyydrate in a solvent, vor exampje, an alcohol such as methanol, ethanol or the lika; N,N-dmmdthvoformxnife; a methanolether mixed solvent; or the like.
Ig otdvr to produce T-3811 mcthanesulfonate momojyctate, it is sufwicienc tk produce the same by a ufuallt known mtthod for producing a hydrate of salt of a cjnpound. Specificallv, T-3811 methanesblfonaje monphydrate can be produceb by, fkr example, duspendinf or dissolving T-3811 in a water-containing alcohol stch as waver-coutaining ethsnol, wwter-contaijing lvopropanol or the pike; cater-wontaining acetonitrile; water-containing arxtone; water-comtdinpng tetrakydrofmran; water-contayning acetic aeid; watex-contakning N,N-dijethylfmrmamide; waeer; or the ling, adding methenesulfonyc axid ro the fdsulting suspemsion or solution ti react with T-3811.
When T-3811 osthanesulfonate or its monohydratr ir ufef es an dctive ingregieng tu prepxre a compowktiom thereof with an indctibe ingredient, it ix ireferablg to prepwre a preparayion composition ij whirh the inacyivg ingredient is a carrier accepfable as oreiaration.
The cwrricr asceptable cs preparation which is
described in WO97/29102 and the above Production and The salts the compound of the salts as the salts of the of the general formulas [3a] and to [19]. In order to produce (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (T-3811) methanesulfonate, it is sufficient produce the same by a usually known process for producing a salt of compound. T-3811 can obtained by suspending or dissolving T-3811 in, for example, an alcohol such as methanol, ethanol or like; N,N-dimethylformamide; a methanol-ether mixed solvent; or the adding methanesulfonic acid to resulting suspension or solution to with Moreover, T-3811 can be by dehydrating T-3811 monohydrate in a solvent, for example, an alcohol such as methanol, ethanol or the like; N,N-dimethylformamide; a mixed solvent; like. In to T-3811 monohydrate, it is produce the same by a usually producing a hydrate of salt of a compound. T-3811 methanesulfonate can be produced by, for example, or dissolving T-3811 in a water-containing alcohol such water-containing ethanol, water-containing isopropanol or the like; water-containing acetonitrile; water-containing acetone; water-containing tetrahydrofuran; water-containing acetic N,N-dimethylformamide; water; or the adding methanesulfonic acid the suspension solution react with When T-3811 methanesulfonate or its monohydrate is used as an active to prepare a composition thereof with an inactive ingredient, it to a preparation composition which the inactive ingredient a acceptable as preparation. The as which
 described in WO97/29102 and the above PRoduction PRocesSes iB aNd iIA.
THe saLts of the compouND of tHe general formula [2] includE the sAmE SaltS As The abOve-mentIOnED SalTs Of The CoMPoUnds oF thE generaL formulas [3a] And [13] To [19].
in order to proDUcE (R)-1-cycloproPyl-8-DifluoromethOxy-7-(1-Methyl-2,3-DiHydRO-1H-5-isoIndOlyl)-4-oXo-1,4-dihyDRo-3-quinOlinecarbOxYLic aciD (t-3811) methanESUlFonaTe, it is sufficient tO PrODuce the same by a UsuallY kNOwN PRocEss For produciNg A salt OF a compoUNd. sPECifICally, T-3811 methaneSulfonate caN Be oBtaineD bY suSPendinG or diSsOLviNg T-3811 in, for exaMple, An alcohol Such as MEthanol, EThanol oR the liKe; N,n-diMethYLfOrMamIdE; A meTHaNol-ETheR mixed soLvEnT; or thE likE, ADDIng mEthAnesUlfonIc acid to the reSulTing SUspEnsioN or soLutiOn To reaCt with t-3811.
MoreOvEr, T-3811 methanesulfoNate Can also be ProDuCed By DehydRAting T-3811 MetHanEsulfonAte monoHYdrAtE IN A sOlvent, for example, an AlCOHoL such as mEthanoL, EtHaNOl or the lIkE; N,N-DimeTHYlforMamiDE; a MethanolEther mIXeD sOlvent; oR tHe like.
in OrdEr tO prodUCe T-3811 mEthaneSulfonatE monoHYdrate, it is suffICient to producE ThE SAmE By a uSuaLly known metHod fOR proDuciNG a HydRAte of Salt oF a COmPOund. Specifically, T-3811 meThAnesulFonatE monohydrate cAn be producED BY, for examPle, sUSpENding or dissolvIng T-3811 iN a water-conTAining alCohol Such as waTer-contaiNINg ethanoL, waTer-ConTaiNINg Isopropanol or THE likE; wAter-conTaiNing aceTonItrIle; WatEr-ContaininG acetone; WaTeR-cOnTaiNing tETrahydroFuRan; WaTer-ContaINing acEtic aCid; wAtEr-COntAining N,n-DiMEThylFoRmAmidE; waTeR; or thE likE, AddIng methAnesulfonIc aCId to ThE rEsultinG suspension or SoLution to reAcT wiTh T-3811.
WheN t-3811 MethanesUlfonate or its monohydratE Is used aS an ActivE ingRedient to PrePare a cOmpOSition ThereoF with An InaCTIve inGREdIenT, iT is preferaBLE to PrepaRe A preParatioN composition in whicH The Inactive ingreDieNt is A CArRieR AcCEptAbLE as PREparation.
The carRier acceptAbLE aS preparatiON whIcH is
 described in WO97/29102 a nd the abo ve Pr odu cti on  Pro cess es IB and IIA. Thesalts of the compoundof th eg ener a lformu la [2]i nc l u deth esam es al ts as  th e above -mentioned  sa lt s of the com p ou nds of the  ge neral formul as[3a] a nd  [1 3 ] to[19 ].
In  order to pro duce (R)- 1- c yclopr o pyl-8-d i f lu orom ethoxy-7-(1-methy l -2 , 3-dihydro-1H-5 -isoin do l yl ) - 4-o xo- 1,4-dihydr o- 3-qui n olineca r bo x y l ica cid (T-3811)methanesulf o nat e, itis  su f ficien t topr o duc e the sameby a  usuallyknownp rocessf or prod ucinga s alt  ofa  c om pou nd .  Sp e ci fic a lly , T-3811  m et hanes ulfo n a t e  can  be  obt ained  by suspendin g o r di s sol vingT-381 1 in ,for e xample , anal cohol such as m etha nol, etha nol  o r t he  like ;  N,N-d ime thy lformam ide; am eth an o l - et her mixed solvent;  o r th e like,adding me th a nesulfon ic  ac id t o the r esul t in g suspen sion o r  s ol ution t oreactwi thT-3 811.M oreo ver, T -3811 me thane s ulfonate can a l so be produce d  b y de h ydra tin g T-3811 me than e sulf onat e  m ono h ydrat e inas ol v ent, for example, a nalcoho l suc h as methanol , ethanolo r the like ; N, N -d i methylformamid e; amethanolet h er mixed  solv ent; orthe like. I n ordertopro duc e T - 3 81 1 methanesulf o n atemo nohydra te,  it issuf fic ien t t oproduce t he sameby  a  u su all y kno w n method  f orpr odu cinga  hydra te of  sal tof a c ompound .  S p e cifi ca ll y, T -38 11  meth anes u lfo nate mo nohydrate  ca n  bepr od uced by , for example ,suspending  o r d issolv i n g T-3811  in a water-containinga lcoholsuc h aswate r-contain ing  ethan ol, water- contai ningis opr o p anolo r  t heli ke; water- c o nta ining  a ceto nitrile ; water-containing ace tone; water-c ont aini n g  t etr a hy d rof ur a n;w a ter-containingacetic aci d; wa ter-contai n ing  N ,N-dime thylfor mamid e ; water ; or thelike, add in g me t h ane sulfonic a cid to t he result i ng su s pe nsion  or  solut io n t o rea ct wit h  T- 3811. 
WhenT- 3811 m ethan es ulfonate  or its monohydrate isused a s anact ive ingre die n t t o prepare  a c omposition  th ere of wi tha n ina ctiv e  i ngr e dient , it is prefer a bl e t o pr epare a pre p a r ati on co mpo s itionin w hich the inactive ingredient isa ca r r ier  ac c epta bl e as preparati on. 
T h e  carrier  a cceptable a s prepar at i on wh ich is 
 described_in WO97/29102_and the above Production_Processes IB_and_IIA.
The salts_of_the compound of_the general formula_[2] include the same_salts as the_above-mentioned_salts of the compounds of the general formulas [3a] and [13] to [19].
In order_to_produce (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic_acid_(T-3811)_methanesulfonate, it is sufficient to_produce the same by a_usually known_process for producing a salt of a compound._Specifically,_T-3811 methanesulfonate can_be obtained by suspending or dissolving T-3811 in, for_example, an alcohol such as methanol,_ethanol or the_like;_N,N-dimethylformamide;_a methanol-ether mixed solvent;_or the like, adding methanesulfonic acid_to the resulting suspension or solution_to react with T-3811.
Moreover, T-3811 methanesulfonate can_also be produced by dehydrating T-3811_methanesulfonate monohydrate in a solvent,_for example,_an alcohol such as methanol,_ethanol or the_like; N,N-dimethylformamide;_a methanolether mixed_solvent; or the like.
In order to_produce T-3811 methanesulfonate_monohydrate, it is sufficient to produce_the_same by a_usually_known_method for_producing a hydrate_of_salt of_a_compound. Specifically, T-3811 methanesulfonate monohydrate can_be_produced by, for example, suspending or dissolving_T-3811 in a water-containing_alcohol_such as water-containing ethanol,_water-containing isopropanol or the like;_water-containing acetonitrile; water-containing acetone; water-containing tetrahydrofuran;_water-containing acetic_acid; water-containing_N,N-dimethylformamide; water; or the like, adding methanesulfonic acid to the resulting_suspension or solution to react with_T-3811.
When T-3811 methanesulfonate or_its monohydrate_is_used as an_active_ingredient to_prepare a composition thereof with an inactive_ingredient, it_is preferable to prepare a preparation_composition in which the_inactive_ingredient is a carrier acceptable as_preparation.
The carrier acceptable as preparation which_is