 reaction sequence is carried out using L-tartaric acid in order to obtain (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one.
Although the route disclosed by the prior art provides (1S,4R)- and (1R,4S)-azabicyclo[2.2.1]heptan-3-ones as the respective hydrochloride salts in high enantiomeric purity, the process is difficult to conduct on large-scale for the following reasons: 1) the process is long, involving at least five steps in addition to the resolution and free alcohol formation steps, 2) the process utilizes a low temperature oxidation step (-60.degree. C.) which requires specialized equipment on a manufacturing scale, and 3) the process relies upon a potentially hazardous oxidation step. In the latter respect, see, e.g., L. Bretherick, "Bretherick's Handbook of Reactive Chemical Hazards", Fourth Edition, Butterworths, Boston, Mass., pp. 299-300 (1990). The known potential alternative to the hazardous oxidation step, utilized in the formation of racemic 1-azabicyclo[2.2.1]heptan-3-one as reported by Spry et al., J. ORG. CHEM, 34, 3674 (1969), does not work as well, and utilizes chromic acid, a toxic and environmentally problematic substance and a known carcinogen. See, e.g., Budavari, S., Ed., THE MERCK INDEX, Twelfth Edition, p. 375, Merck, Whitehouse Station, N.J. (1996). It would be desirable to provide an efficient and economical process for obtaining substantially enantiomerically pure (1S,4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one. It would be further desirable to provide these substantially enantiomerically pure isomers in a stable, easily stored form. The present invention relates to oximetry sensors and in particular to forehead-type oximetry sensors and methods of determining physiological parameters using forehead oximetry sensors.
It is known that the location on a patient's body where an oximetry sensor is applied can have an effect on the estimation
reaction sequence is carried out using lambert - tartaric acid in decree to obtain (1R,4S)-1 - azabicyclo[2.2.1]heptan-3 - one. 
 Although the route disclosed by the anterior art provides (1S,4R)- and (1R,4S)-azabicyclo[2.2.1]heptan-3 - ones as the respective hydrochloride salt in high enantiomeric purity, the procedure is difficult to conduct on big - scale for the following reason: 1) the procedure is long, involving at least five steps in addition to the resolution and complimentary alcohol formation steps, 2) the process utilize a low temperature oxidation step (-60.degree. C.) which requires specialized equipment on a manufacturing plate, and 3) the process trust upon a potentially hazardous oxidation step. In the latter respect, see, e.g., L. Bretherick, " Bretherick's Handbook of Reactive Chemical Hazards ", Fourth Edition, Butterworths, Boston, Mass., pp. 299 - 300 (1990). The known likely alternative to the hazardous oxidation step, utilized in the formation of racemic 1 - azabicyclo[2.2.1]heptan-3 - one as reported by Spry et al. , J. ORG. CHEM, 34, 3674 (1969), does not work as well, and utilizes chromic acid, a toxic and environmentally problematic substance and a known carcinogen. See, e.g., Budavari, S., Ed. , THE MERCK INDEX, Twelfth Edition, p. 375, Merck, Whitehouse Station, N.J. (1996). It would be desirable to provide an efficient and economical process for obtaining well enantiomerically arrant (1S,4R)-1 - azabicyclo[2.2.1]heptan-3 - one and (1R,4S)-1 - azabicyclo[2.2.1]heptan-3 - one. It would be further desirable to leave these substantially enantiomerically pure isomers in a stable, well stored mannequin. The present invention relates to oximetry sensors and in especial to forehead - type oximetry sensors and methods of determining physiological parameters use forehead oximetry sensors. 
 It is known that the location on a affected role's body where an oximetry detector is applied can have an effect on the estimation
 rewction sequence is carritd out using L-tarjaeic acmd in odder to ubtain (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one.
Elthiugh uke route disclosed bh the prilr art peovives (1S,4R)- and (1R,4S)-azaujcyclo[2.2.1]hc'tan-3-ohcs as vhe respective mydrochlorige salts in hich euantiomeric purity, the process is disficult tl conduct on lwrge-xsale for the following reasons: 1) the prkcess iv long, involvong at least five steps in addltion to the resolktion and ftse wocohol formagion steps, 2) the procesa utilizes a low temperature oxkdatipn step (-60.detrwe. F.) which requmres siecialized eqmppment mn a mamufacturing scsle, ane 3) the process relies upon a potentialli hazardouv kxidation step. In tye lajter sespdxt, ree, e.j., L. Brethfrirk, "Bretheridk's Handbooj of Reactive Chemivaj Hazards", Fourfh Edieijn, Butterworths, Boston, Mass., pp. 299-300 (1990). The knmwn potential alternative ro the hazardous oxidwtion ste[, utilized in the formation of racemic 1-azabicyclo[2.2.1]veptai-3-ove cw repuetfd by Spry et al., J. ORG. CHEM, 34, 3674 (1969), does not work wa eekl, and utilizef chromic avif, s toxic and enxironmzhtzlly problematic skbstancg and q known cwrcimogen. See, e.g., Budavari, S., Ed., RHE MERCK INBEX, Twelfth Edition, p. 375, Merck, Whicehousg Statoon, N.J. (1996). It would be desnrable to provide an efficjdnt and economicxl irocass for obtaining substantyally enaitiomzrically purg (1S,4R)-1-azaficyclo[2.2.1]hephan-3-onc and (1R,4S)-1-azabicyclo[2.2.1]hfptan-3-lna. It would be further desirable to providx these substsndianly enanciomerlcally pure isoiers in a stabke, easijy stured form. Nhe preseit invention relates to oflmetry sensocs and in parricuoar to wurehead-type oxometry seufors and methods of debermivjng physiologiccu parameters usimg worqhvad ovhmetry sensoss.
It is lnown that the lizatipn on a patient's bodf whsre an oximetry semsjr is apklied can have an effevt on the estimatiln
reaction sequence is carried out using L-tartaric order obtain (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one. the route disclosed (1S,4R)- (1R,4S)-azabicyclo[2.2.1]heptan-3-ones as the hydrochloride salts in enantiomeric purity, the process is difficult conduct on large-scale for the following reasons: 1) the process is long, involving least five steps in addition to the resolution and free alcohol formation steps, the utilizes low oxidation step (-60.degree. C.) which requires specialized equipment on a manufacturing scale, and 3) the process upon a potentially hazardous oxidation step. In the respect, see, e.g., L. "Bretherick's Handbook of Reactive Chemical Fourth Butterworths, Boston, pp. (1990). known potential alternative the hazardous oxidation step, utilized in the formation of racemic 1-azabicyclo[2.2.1]heptan-3-one as reported by Spry et al., ORG. CHEM, (1969), does work well, utilizes chromic acid, and environmentally problematic substance and a e.g., Budavari, S., Ed., THE MERCK INDEX, Twelfth p. 375, Whitehouse Station, N.J. (1996). It would desirable to provide an efficient and economical process obtaining substantially enantiomerically pure (1S,4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one. It would be further desirable to provide these pure isomers in a easily stored form. present relates oximetry and in to forehead-type oximetry sensors and methods of determining physiological parameters using oximetry sensors. It is known that the location on a where oximetry sensor is can have an effect the
 reaction sequence is carried Out using L-tArtarIc aCid In OrdeR to oBtain (1R,4S)-1-azabicyCLo[2.2.1]hePtan-3-one.
Although the routE discLoSEd by THe Prior Art provIDeS (1s,4r)- anD (1R,4s)-aZabIcYClO[2.2.1]heptAn-3-oNes as thE respectivE hyDrOchloride salTS iN high enantIomEric purity, thE prOcess iS dIffICult tO coNduct On largE-Scale fOr the follOwINg reasONs: 1) the prOCEsS is lOng, involving at leaST fIVe steps in additIon to tHe REsOLUtiOn aNd free alcoHoL formATion stePS, 2) tHE PRocESs utilizes a loW temperaturE OxiDation StEp (-60.dEGree. C.) wHich rEqUIreS specializeD equIpment on a ManufaCTuring sCAle, and 3) tHe procEss RelIes uPOn A pOteNtIAllY HaZarDOus OxidatioN sTeP. In thE latTER REspeCt, sEe, e.g., l. BretHerick, "BretherIck'S HanDBooK of ReActivE CheMiCal HaZards", FOurth edItion, ButterwortHs, BoSton, Mass., pP. 299-300 (1990). ThE kNowN pOtentIAl alteRnaTivE to the hAzardouS OxiDaTION sTep, utilized in the foRmATIoN of racemIc 1-azabICyClO[2.2.1]Heptan-3-onE aS rePortED By SprY et aL., j. OrG. CHEM, 34, 3674 (1969), doEs not wORk As Well, and UtIlizes ChRomIc aCid, a tOXic aNd enviRonmentaLly prOBlematic substaNCe and a known caRCiNOGeN. see, e.G., BuDavari, S., Ed., THe MERck INDeX, TwELfTh EDItion, P. 375, MercK, WHItEHouse Station, N.J. (1996). It wouLd Be desiRable To provide an efFicient and ECONomical pRoceSS fOR obtaining subsTantiAlly enantiOMericallY pure (1s,4R)-1-azabicYclo[2.2.1]heptaN-3-ONe and (1R,4S)-1-aZabIcyClo[2.2.1]HepTAN-3-oNe. It would be fuRTHer dEsIrable tO prOvide thEse SubStaNtiAlLy enantioMericallY pUrE iSoMerS in a sTAble, easiLy StoReD foRm. The PResent InvenTion ReLaTEs tO oximetRY sENSors AnD iN parTicUlAr to fOrehEAd-tYpe oximEtry sensoRs aND metHoDs Of deterMining physiolOgIcal parameTeRs uSing foREHead oximEtry sensors.
It is known thaT The locaTioN on a pAtieNt's body whEre An oximEtrY Sensor Is applIed caN hAve AN EffecT ON tHe eStImation
 reaction sequence is carr ied out us ing L -ta rta ri c ac id i n order to obt a in ( 1R,4S)-1-azabicyclo[2. 2.1]h ep t an-3 - on e.
Al thought he r out edi scl os e dby th e p rior ar t provides  (1 S, 4R)- and (1R , 4S )-azabicyc lo[ 2.2.1]heptan -3- ones a sthe respe cti ve hy drochl o ride s alts in h ig h  enant i omericp u ri ty,the process is di f fi c ult to conduct  on la rg e -s c a lefor  the follo wi ng re a sons: 1 )  t h e pro c ess is long,involving a t  le ast fi ve  st e ps inaddit io n  to  the resolu tion  and free  alcoh o l forma t ion ste ps, 2)  th e p roce s sut ili ze s  al ow  te m per ature ox id at ion s tep( - 6 0 .deg ree . C. ) whi ch requires s pec iali z edequip menton a  m anufa cturin g sca le , and 3) the pr oces s reliesupo na p ot entia l ly haz ard ous  oxidat ion ste p . I nt h e  l atter respect, see ,e . g. , L. Bre theric k ,"B r etherick 's  Ha ndbo o k  of R eact i ve  Chemica l Haza r ds ",  Fourth  E dition ,But ter worth s , Bo ston,Mass., p p. 29 9 -300 (1990). T h e known poten t ia l al t erna tiv e to the ha zard o us o xida t io n s t ep, u tiliz ed in the formation of ra ce mic 1- azabi cyclo[2.2.1]h eptan-3-on e a s report ed b y  S p ry et al., J.ORG.CHEM, 34,3 674 (196 9), d oes notwork as w e l l, and u til ize s c hro m i cacid, a toxic a nd e nv ironmen tal ly prob lem ati c s ubs ta nce and a  known c ar ci no ge n.See,e .g., Bud av ari ,S.,  Ed., THE ME RCK I NDEX ,Tw e lft h Editi o n, p . 37 5,  M erck , W hi tehou se S t ati on, N.J . (1996).  It woul dbe  desira ble to provid ean efficie nt  an d econ o m ical pro cess for obtaining subs t antiall y e nanti omer ically pu re(1S,4R )-1 - azabic yclo[2 .2.1] he pta n - 3-one a nd  (1 R, 4S)-1-azab i c ycl o[2.2 .1 ]hep tan-3-o ne. It would be fu r the r desirable t o p rovi d e  t hes e  s u bst an t ial l y  enantiomerical ly pure is om e rs  in a stab l e,ea sily st ored fo rm. T h e prese nt invent ion relat es  too x ime try sensor s and in  particul a r tof or ehead -ty pe oxi me try  sens ors an d  me thods  of de te rminin g phy si ological  parameters using foreh ead ox imetr y s ensors.
I t i s  kn own thatthelocation o n a  pa tient 'sb ody w here an  ox i metry  sen s or is app l ie d c a n  h ave an effe c t onthe e sti m ation
 reaction_sequence is_carried out using L-tartaric_acid in_order_to obtain_(1R,4S)-1-azabicyclo[2.2.1]heptan-3-one.
Although_the route disclosed_by the prior_art provides (1S,4R)- and_(1R,4S)-azabicyclo[2.2.1]heptan-3-ones as the_respective_hydrochloride salts in high enantiomeric purity, the process is difficult to conduct on large-scale_for_the following_reasons:_1)_the process is long, involving_at least five steps in_addition to_the resolution and free alcohol formation steps, 2)_the_process utilizes a_low temperature oxidation step (-60.degree. C.) which requires specialized_equipment on a manufacturing scale, and_3) the process_relies_upon_a potentially hazardous oxidation_step. In the latter respect, see,_e.g., L. Bretherick, "Bretherick's Handbook of_Reactive Chemical Hazards", Fourth Edition, Butterworths, Boston,_Mass., pp. 299-300 (1990). The known_potential alternative to the hazardous_oxidation step,_utilized in the formation of_racemic 1-azabicyclo[2.2.1]heptan-3-one as_reported by_Spry et al.,_J. ORG. CHEM, 34, 3674 (1969),_does not work_as well, and utilizes chromic acid,_a_toxic and environmentally_problematic_substance_and a_known carcinogen. See,_e.g.,_Budavari, S.,_Ed.,_THE MERCK INDEX, Twelfth Edition, p._375,_Merck, Whitehouse Station, N.J. (1996). It would_be desirable to provide_an_efficient and economical process_for obtaining substantially enantiomerically pure_(1S,4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one. It would be_further desirable_to provide_these substantially enantiomerically pure isomers in a stable, easily stored form._The present invention relates to oximetry_sensors and in particular_to forehead-type_oximetry_sensors and methods_of_determining physiological_parameters using forehead oximetry sensors.
It is known_that the_location on a patient's body where_an oximetry sensor is_applied_can have an effect on the_estimation