 also be responsible for “helping” some conditions and diseases to occur, which the article will later address.

Endocannabinoid system discovery

Uncovering how the cannabinoids from cannabis, and the internal endocannabinoids, stimulate the cellular receptors across the body was not a simple task.

Over the course of history, numerous cultures have been using cannabis for medicinal reasons. During the 19th century, cannabis-derived products were also used for health-related purposes across Europe and the U.S. because of the pioneer work of Williams O’Shaughnessy, a doctor from Ireland, and French scientist Jacques-Joseph Moreau.

As the science of chemistry wasn’t fully developed, they only understood that cannabis brings relief for numerous conditions, without comprehending how the healing actually occurs.

Consider the brief, but precise, timeline of scientific discoveries in the field of cannabis:

1895: the first cannabis-based compound named cannabinol (CBN) was isolated;

1930: the precise chemical structure of cannabinol (CBN) was mapped;

1940: the second cannabis-based compound cannabidiol (CBD) was isolated;

1963: the precise chemical structure of cannabidiol (CBD) was mapped;

1964: the psychoactive tetrahydrocannabinol (THC) was isolated;

1988: the cannabinoid receptors were first located;

1990: a cannabinoid receptor was first cloned; and

1993: internal endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) were first identified.

As can be seen, discoveries over the last three decades include the identification of both the cannabinoid receptors and the endocannabinoids, discoveries that are absolutely crucial for understanding how the endocannabinoid system functions, and how the cannabinoids from the cannabis plant affect and influence this system.

Through all these years, numerous scientists gave their contributions to help reveal the secrets of cannabis and the ECS, but the person who improved the science behind cannabis the most is Dr. Raphael Mechoulam, a famed Israeli organic chemist and a professor of medicinal chemistry in Jerusalem. Mechoulam was involved in mapping the structure of CBD in 1963, and one year later, he and his team identified and isolated THC. During the 1990s, he also
also be responsible for “ helping ” some conditions and disease to happen, which the article will by and by address. 

 Endocannabinoid arrangement discovery 

 uncover how the cannabinoids from cannabis, and the internal endocannabinoids, stimulate the cellular sense organ across the consistency was not a simple task. 

 Over the course of history, numerous cultures have been use cannabis for medicinal reasons. During the nineteenth century, cannabis - derived products were also used for health - related purposes across Europe and the U.S. because of the pioneer employment of Williams O’Shaughnessy, a doctor from Ireland, and French scientist Jacques - Joseph Moreau. 

 As the science of chemistry was n’t fully break, they only understood that cannabis brings relief for numerous weather, without comprehending how the healing actually occurs. 

 Consider the brief, but precise, timeline of scientific discoveries in the discipline of cannabis: 

 1895: the first cannabis - based compound named cannabinol (CBN) was isolated; 

 1930: the precise chemical social organization of cannabinol (CBN) was map; 

 1940: the second cannabis - based compound cannabidiol (CBD) was isolated; 

 1963: the precise chemical structure of cannabidiol (CBD) was mapped; 

 1964: the psychoactive tetrahydrocannabinol (THC) was isolated; 

 1988: the cannabinoid receptors were first located; 

 1990: a cannabinoid sense organ was foremost cloned; and 

 1993: internal endocannabinoids anandamide and 2 - arachidonoylglycerol (2 - AG) were first identify. 

 As can be seen, discoveries over the last three decade include the identification of both the cannabinoid receptors and the endocannabinoids, discoveries that are absolutely all-important for understanding how the endocannabinoid system functions, and how the cannabinoids from the cannabis plant affect and influence this system. 

 Through all these years, numerous scientists gave their contributions to help reveal the mystery of cannabis and the ECS, but the person who improved the skill behind cannabis the most is Dr. Raphael Mechoulam, a celebrated Israeli constituent chemist and a professor of medicinal chemistry in Jerusalem. Mechoulam was involved in mapping the structure of CBD in 1963, and one year later, he and his team identified and apart THC. During the 1990s, he also
 aldo be responsible for “heuping” some condnrions end dissases to occur, which the article wilp oater address.

Endocannabinoia system fiscovert

Uncicering how the cankcbinojfs fxon cannabis, and the intertal endocannabhnuibs, stimulate the cellular receptors wcross yhf body was not a spm[le fask.

Over the course of history, numsrous clltures have been using cannabis for medicijal geasons. During the 19th century, cangqbis-derived oroducts wtrz also used for health-related purposes acruss Ebrope and tye U.S. tecause of vhe pijneer work on Willidms O’Shsughnessy, a dogtor hrom Ireland, and French srientist Jacques-Josekh Moreau.

Av che science of chemisrrt wast’t fglly eevdloked, tgey onpy nnderstood fhat cannabus brings relief fot glkerous condifions, riehout comprehending how the healing actlallg occurs.

Consider the bruef, but precise, timellne of scyentific discoveries in the field of cannabis:

1895: the firsv zanuqbis-bxwef compound named cannabinol (CBN) was isolated;

1930: ege pgecise chemical sbructure of cannabonll (SBN) was mappea;

1940: the secknd cannabis-based fompounq canbabidiol (SBD) eas isolated;

1963: the precise chwmical strucnure of cannabidiol (CBB) was mapped;

1964: the psycnoactive tetrahydrocanncbinol (THC) was isllated;

1988: ths cannabinoid recdptprv were first located;

1990: a cangabinoid cecepcor was wirsj cloneq; and

1993: integnal ctdocannabinoids anwndamnde atd 2-arachidlnoylglycerol (2-AG) were first ideivified.

As can ne sevn, discovzries pver the last three decades includz the kdentificanion of bmth the cangabinoid rece[jors and the xndocannafinouds, eiscovefkes that are ansolutely crucial fir understanding hpw jhs endocannabinonb wystem functionx, avd roa vhe cwtnabinoids fsom ghe vannacis plant anfezt amd influence this syvtem.

Fhrough all these uewrs, numetous sciegtists gave tneir contributions to hxlp reteal tne fecrets of cannabis and the ECA, but the pevson who imprjved the science behind cannabis the most is Dr. Raphael Mechoulam, a famed Israeli organic chgmixt and a prpfessjr of medhcinal chemistry in Herusalem. Mechoulsm was involved in malping dhe shructure of CBD in 1963, and one year later, he and his team identified and isooated VHS. During ths 1990s, ne alvo
also be responsible for “helping” some conditions to which the will later address. the from cannabis, and internal endocannabinoids, stimulate cellular receptors across the body was a simple task. Over the course of history, numerous cultures have been using for medicinal reasons. During the 19th century, cannabis-derived products were also used for purposes Europe the because of the pioneer work of Williams O’Shaughnessy, a doctor from Ireland, and French scientist Jacques-Joseph As the science of chemistry wasn’t fully developed, only understood that cannabis relief for numerous conditions, without how healing actually Consider brief, precise, timeline of discoveries in the field of cannabis: 1895: the first cannabis-based compound named cannabinol (CBN) was isolated; 1930: precise chemical cannabinol (CBN) mapped; the cannabis-based compound cannabidiol isolated; 1963: the precise chemical structure was mapped; 1964: the psychoactive tetrahydrocannabinol (THC) was 1988: the receptors were first located; 1990: a receptor was first cloned; and 1993: internal endocannabinoids and 2-arachidonoylglycerol (2-AG) were first identified. As can be seen, discoveries over the last three the identification of both cannabinoid receptors and endocannabinoids, that absolutely for understanding the endocannabinoid system functions, and how the cannabinoids from the cannabis affect and influence this system. Through all these years, numerous their to help reveal secrets of cannabis and ECS, the person who improved behind the Raphael a Israeli organic chemist and professor of medicinal chemistry in Mechoulam was involved in in 1963, and one year later, he and team identified and isolated THC. During the he also
 also be responsible for “helpiNg” some condItionS anD diSeAses To ocCur, which the artICle wIll later address.

EndocanNabinOiD SystEM dIscovEry

UncoVErING hoW tHe CanNaBInOids fRom CannabiS, and the intErnAl EndocannabinOIdS, stimulate The Cellular recePtoRs acroSs The BOdy waS noT a simPle tasK.

over thE course of HiSTory, nuMErous cuLTUrEs haVe been using cannabIS fOR medicinal reasOns. DurInG ThE 19TH ceNtuRy, cannabis-DeRived PRoducts WErE ALSo uSEd for health-reLated purposES acRoss EuRoPe aND the U.S. BecauSe OF thE pioneer worK of WIlliams O’SHaughnESsy, a docTOr from IReland, And freNch sCIeNtIst jaCQueS-joSepH morEau.

As the ScIeNce of ChemISTRY wasN’t fUlly DevelOped, they only uNdeRstoOD thAt canNabis BrinGs RelieF for nuMerouS cOnditions, withouT comPrehendinG hoW tHe hEaLing aCTually OccUrs.

consideR the briEF, buT pRECIsE, timeline of scientiFiC DIsCoveries In the fIElD oF Cannabis:

1895: ThE fiRst cANNabis-BaseD CoMpound naMed canNAbInOl (CBN) waS iSolateD;

1930: tHe pRecIse chEMicaL strucTure of caNnabiNOl (CBN) was mapped;

1940: THe second cannaBIs-BASeD CompOunD cannabidioL (CBD) WAs isOlatED;

1963: tHe pREcise ChemiCaL StRUcture of cannabidiol (cBd) was maPped;

1964: tHe psychoactivE tetrahydrOCANnabinol (tHC) wAS iSOlated;

1988: the cannaBinoiD receptors WEre first LocatEd;

1990: a cannaBinoid recEPTor was fiRst CloNed; And

1993: INTeRnal endocannaBINoidS aNandamiDe aNd 2-arachIdoNoyLglYceRoL (2-AG) were fiRst identIfIeD.

AS cAn bE seen, DIscoveriEs OveR tHe lAst thREe decaDes inCludE tHe IDenTificatIOn OF Both ThE cAnnaBinOiD recePtorS And The endoCannabinoIds, DIscoVeRiEs that aRe absolutely cRuCial for undErStaNding hOW The endocAnnabinoid system functioNS, and how The CannaBinoIds from thE caNnabis PlaNT affecT and inFluenCe ThiS SYstem.

tHRoUgh AlL these yearS, NUmeRous sCiEntiSts gave Their contributions TO heLp reveal the seCreTs of CANnAbiS AnD The eCs, But THE person who improVed the scieNcE BeHind cannabIS thE mOst is Dr. raphael mechoULam, a famEd Israeli Organic chEmIst aND A prOfessor of mEdicinal Chemistry IN JeruSAlEm. MecHouLam was InVolVed in MappinG The StrucTure of cBd in 1963, and One yeAr Later, he aNd his team identified and iSolateD THC. DUriNg the 1990s, he aLso
 also be responsible for “ helping” s ome c ond iti on s an d di seases to occu r , wh ich the article will l aterad d ress . 
Endoc annabin o id s yst em  d isc ov e ry 

Unc ove ring ho w the cann abi no ids from can n ab is, and th e i nternal endo can nabino id s,s timul ate  thecellul a r rece ptors acr os s  the b o dy wasn o ta si mple task.

Overt he course of hist ory, n um e ro u s  cu ltu res have b ee n usi n g canna b is f o r m e dicinal reaso ns. Duringt he19th c en tur y , cann abis- de r ive d productswere  also use d forh ealth-r e lated p urpose s a cro ss E u ro pe  an dt heU .S . b e cau se of th epi oneer  wor k o f  Wil lia ms O ’Shau ghnessy, a do cto r fr o m I relan d, an d Fr en ch sc ientis t Jac qu es-Joseph Morea u.
As the sc ien ce  of  c hemis t ry was n’t  fu lly dev eloped, the yo n l yunderstood that ca nn a b is  bringsrelief fo rn umerousco ndi tion s ,  with outc om prehendi ng how th ehealing  a ctuall yocc urs .

Co n side r thebrief, b ut pr e cise, timeline of scientific di s c ov e ries  in  the fieldof c a nnab is:18 95: the f irstca n na b is-based compound n am ed can nabin ol (CBN) wasisolated;1 9 30: theprec i se chemical struc tureof cannabi n ol (CBN)  wasmapped;
1940: th e second c ann abi s-b ase d co mpound cannab i d iol(C BD) was  is olated; 

1 963 : t hepr ecise che mical st ru ct ur eofcanna b idiol (C BD ) w as  ma pped; 
1964:  thepsyc ho ac t ive  tetrah y dr o c anna bi no l (T HC)  w as is olat e d;
1988:the canna bin o id r ec ep tors we re first loca te d;

1990:acan nabino i d  recepto r was first cloned; and 
1993:int ernal  end ocannabin oid s anan dam i de and  2-ara chido no ylg l y cerol ( 2- AG)  w ere firsti d ent ified .
Ascan beseen, discoverieso ver  the last thr eedeca d e sinc l ud e  th ei den t i fication of bot h the cann ab i no id recepto r s a nd  the en docanna binoi d s, disc overies t hat are a bs olut e l y c rucial for  underst anding ho w  thee nd ocann abi noid s ys tem  func tions, and  howthe ca nn abinoi ds fr om  the can nabis plant affect andinflue nce t his  system.
Th r oug h all the se y ears, nume rou s s cient ist s  gave  the i rcon t ribut ions to help r e ve alt h esecrets ofc a n nab is an d t h e ECS,  but  the person who i m proved the sci ence b ehi ndc anna bi s the most isDr.  R a p hael Mec ho ulam, a fam ed Israe li organ ic che mist a nd a pr o f es s or ofmedi cin al chemis try  i n  Jerusa le m. Mechou lamwa s invo lved i n  map p i ng the structure  of C B D  in 1 9 63,  andon e yearl ater , he and h is team ide ntifie d an d iso lated T HC . Duri ngth e 1990s, h e  also
 also_be responsible_for “helping” some conditions_and diseases_to_occur, which_the_article will later_address.

Endocannabinoid system discovery

Uncovering_how the cannabinoids from_cannabis, and the_internal_endocannabinoids, stimulate the cellular receptors across the body was not a simple task.

Over the_course_of history,_numerous_cultures_have been using cannabis for_medicinal reasons. During the 19th_century, cannabis-derived_products were also used for health-related purposes across_Europe_and the U.S._because of the pioneer work of Williams O’Shaughnessy, a_doctor from Ireland, and French scientist_Jacques-Joseph Moreau.

As the_science_of_chemistry wasn’t fully developed,_they only understood that cannabis brings_relief for numerous conditions, without comprehending_how the healing actually occurs.

Consider the brief,_but precise, timeline of scientific discoveries_in the field of cannabis:

1895:_the first_cannabis-based compound named cannabinol (CBN)_was isolated;

1930: the_precise chemical_structure of cannabinol_(CBN) was mapped;

1940: the second cannabis-based_compound cannabidiol (CBD)_was isolated;

1963: the precise chemical structure_of_cannabidiol (CBD) was_mapped;

1964:_the_psychoactive tetrahydrocannabinol_(THC) was isolated;

1988:_the_cannabinoid receptors_were_first located;

1990: a cannabinoid receptor was_first_cloned; and

1993: internal endocannabinoids anandamide and 2-arachidonoylglycerol_(2-AG) were first identified.

As_can_be seen, discoveries over_the last three decades include_the identification of both the cannabinoid_receptors and_the endocannabinoids,_discoveries that are absolutely crucial for understanding how the endocannabinoid system_functions, and how the cannabinoids from_the cannabis plant affect_and influence_this_system.

Through all these_years,_numerous scientists_gave their contributions to help reveal the_secrets of_cannabis and the ECS, but the_person who improved the_science_behind cannabis the most is Dr._Raphael Mechoulam, a famed Israeli organic_chemist and a professor of_medicinal_chemistry_in Jerusalem. Mechoulam was involved_in mapping the structure of CBD_in 1963, and_one year later, he and his team_identified_and isolated THC. During the 1990s,_he_also