, as well as this Sakuga Blog. Thanks to everyone who’s helped out so far!

Become a Patron! Story highlights Scientists grow reproductive organs and nasal cartilage

Both are successfully implanted in patients

Organs are made with scaffolds that, over time, melt into the body

Complications among patients have been virtually nonexistent

Two body parts. One scientific leap.

Scientists in the United States, Mexico and Switzerland grew reproductive organs and nasal cartilage in labs, and successfully implanted them in patients, according to two studies released in The Lancet on Thursday.

It is not the first time scientists have engineered body parts -- in effect, creating organs where before there were none. What is different in these cases is the size and complexity of the organs.

"This is a move forward to even more challenging (organs)," said Ivan Martin, a professor of tissue engineering at University Hospital Basel in Switzerland, and co-author of the nasal cartilage study.

"All these incremental steps finally have demonstrated that it is possible to engineer tissue that can help patients."

Tissue engineering has focused primarily on repair: burned skin, muscle shorn off during in an accident, a dysfunctional bladder. Recent advances go beyond repair to replacement.

One of the two new studies involves a group of four teenage patients born with a rare condition called Mayer-Rokitansky-Küster-Hauser Syndrome. The patients had either a missing or deformed uterus, an absent or ill-formed vagina, or some other dysfunction.

The process for recreating their reproductive systems sounds deceptively simple.

It begins with scientists creating a 3-D scaffold that mirrors the dimensions of the patients' missing organs. They then take small swatches of muscle and tissue from the patients, and extract cells.

Those cells are then used to "seed" (or spread across) various surfaces of the 3-D scaffolds, where they grow for a few weeks outside the body.

"This is not like a defective organ that you augment or something you put in between two places," said Dr. Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine and lead author of the vaginal organ study. "We had to create the organ. We put it in de novo (anew)."

Organ scaffolds serve multiple purposes: They provide a framework upon which the new organ can grow. They also are made
, as well as this Sakuga Blog. Thanks to everyone who ’s helped out so far! 

 Become a Patron! Story highlight scientist grow reproductive organ and adenoidal cartilage 

 Both are successfully implanted in patients 

 Organs are have with scaffolds that, over time, dissolve into the body 

 Complications among patients have been about nonexistent 

 Two body parts. One scientific leap. 

 Scientists in the United States, Mexico and Switzerland grow reproductive organs and nasal cartilage in labs, and successfully implanted them in patient, according to two studies released in The Lancet on Thursday. 

 It is not the beginning time scientists have engineered body part -- in effect, creating organs where before there were none. What is different in these case is the size and complexity of the organs. 

 " This is a move forward to even more challenging (organs), " say Ivan Martin, a professor of tissue engineering at University Hospital Basel in Switzerland, and co - author of the nasal cartilage study. 

 " All these incremental steps finally have demonstrated that it is possible to engineer tissue that can help oneself patients. " 

 Tissue engineering has concenter chiefly on repair: burned skin, muscle shorn off during in an accident, a dysfunctional bladder. Recent advances go beyond repair to successor. 

 One of the two new studies involves a group of four teenage affected role born with a rare condition called Mayer - Rokitansky - Küster - Hauser Syndrome. The patients receive either a missing or deform uterus, an absent or ill - formed vagina, or some other dysfunction. 

 The process for recreating their generative systems sounds deceptively simple. 

 It begins with scientists creating a 3 - D scaffold that mirrors the dimensions of the affected role' missing organ. They then take small swatch of muscle and tissue from the patients, and extract cells. 

 Those cellular telephone are then used to " semen " (or spread across) various surface of the 3 - D scaffold, where they grow for a few weeks outside the body. 

 " This is not like a defective organ that you augment or something you put in between two places, " said Dr. Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine and leave author of the vaginal organ survey. " We had to create the organ. We put it in de novo (anew). " 

 Organ scaffolds suffice multiple purposes: They provide a framework upon which the new organ can grow. They besides are made
, as well as this Sakuga Blon. Thanks to everiobe who’v helpsd out su far!

Become a Patron! Story hmghlughts Scientists grow reproauctive oggans and nasel cartilage

Both are sucgzssfumpy ik'lanted in patignts

Organs ase made with swawfllds that, over time, melt into the bjdy

Compkifations among katiemes hzne been virtually nonexistent

Twk body karts. One scientifoc leap.

Scientists in the Ujitef States, Mexico anf Switzerlabd gwww reproductkve organs and nasal czrtilage in labs, and successfuluy im'lanted then un odtients, accirdind to two studies relaased im The Lancet ok Thucsdat.

It is not the first vime scientists have engineerad body parts -- in edfwct, cteatitg oftanr wgece gefore thxre were nohe. What is eifferent in these vafvx is the sizs and soiplexity of the organs.

"This is a move fogwars to even more challengung (organs)," said Ivan Lartin, a [rofessor of tissue engineering at University Hos[ital Castl in Sdutxerland, and co-author of the nasal cartilage sehdu.

"Akl these increiental stepx vimwlly have demunstracsd that it is possibpe to egginewr tissue thay can help patients."

Tissue ebgineering hcs docused primarily ln repair: bbrned xkin, kuscle shorn off during in zn accident, a dysfundgional bladder. Rdcekt ddvances go beyond repair eo replacxment.

Pne of ghe jwo new studies ijvolvcv a group of four heenaye padients borj with a rare condition called Mayer-Rokitanski-Küsder-Vauser Svndromc. The patients rad either a mnssing ox defofmed uterua, an abvent or ill-sormed vagina, lr some othec dysfunceion.

Rhe process wor recreating their reirjducrive systems soundx dgcsptively simple.

Nu btguns with scienyisgs srvatmng a 3-G scaffold tvat oirfprs tfe dimensioks uf tne patients' missing mrgahs. They then take xmwll swatxhes of iuscle and tixsue from the patitnts, aid extcact crllf.

Those cells are then used to "aeed" (or sorewd across) vawiouw surfaces oy the 3-D scaffolds, where they grow for a hew weeks outside the bidy.

"This is not like s defective orgag that yog augment or somethibg you put in beteeen two places," said Sr. Antvony Wtala, director of the Wake Forest Institute for Regenerative Medicine and lead euehor of the vagonal mryan study. "We iav to create the oggan. We put it in de novo (anew)."

Orjan scaffondf serve multiple purposes: Thry provide a frxmework upon which the nsw organ can grow. They also are made
, as well as this Sakuga Blog. everyone helped out far! Become a reproductive and nasal cartilage are successfully implanted patients Organs are made with scaffolds over time, melt into the body Complications among patients have been virtually nonexistent body parts. One scientific leap. Scientists in the United States, Mexico and Switzerland reproductive and cartilage labs, and successfully implanted them in patients, according to two studies released in The Lancet on It is not the first time scientists have body parts -- in creating organs where before there none. is different these is size and complexity the organs. "This is a move forward to even more challenging (organs)," said Ivan Martin, a professor tissue engineering Hospital Basel Switzerland, co-author the nasal cartilage these incremental steps finally have demonstrated possible to engineer tissue that can help patients." engineering has primarily on repair: burned skin, muscle off during in an accident, a dysfunctional bladder. advances go beyond repair to replacement. One of the two new studies involves a group teenage patients born with rare condition called Syndrome. patients either missing or uterus, an absent or ill-formed vagina, or some other dysfunction. The for recreating their reproductive systems sounds deceptively simple. It begins creating 3-D scaffold that the dimensions of the missing They then take small muscle tissue and cells. cells are then used "seed" (or spread across) various of the 3-D scaffolds, few weeks outside the body. "This is not a defective organ that you augment or you put in between two places," said Dr. Anthony Atala, director of Wake Forest Regenerative Medicine and lead author of the vaginal study. "We had to the organ. We put it in de novo (anew)." scaffolds multiple purposes: provide a framework which the new can grow. They made
, as well as this Sakuga Blog. ThaNks to everyOne whO’s hElpEd Out sO far!

become a Patron! STOry hIghlights Scientists groW reprOdUCtivE OrGans aNd nasal CArTILagE

BOtH arE sUCcEssfuLly ImplantEd in patienTs

ORgAns are made wiTH sCaffolds thAt, oVer time, melt iNto The bodY

COmpLIcatiOns Among PatienTS have bEen virtuaLlY NonexiSTent

Two BODy PartS. One scientific leaP.

scIEntists in the UnIted StAtES, MEXIco And switzerlanD gRew rePRoductiVE oRGANs aND nasal cartilaGe in labs, and SUccEssfulLy ImpLAnted tHem in PaTIenTs, according To twO studies rEleaseD In The LaNCet on ThUrsday.

it iS noT the FIrSt TimE sCIenTIsTs hAVe eNgineereD bOdY partS -- in eFFECT, creAtiNg orGans wHere before theRe wEre nONe. WHat is DiffeRent In These Cases iS the sIzE and complexity oF the Organs.

"ThiS is A mOve FoRward TO even mOre ChaLlenginG (organs)," SAid ivAN mArTin, a professor of tisSuE ENgIneering At UnivERsItY hospital baSel In SwITZerlaNd, anD Co-Author of The nasAL cArTilage sTuDy.

"All tHeSe iNcrEmentAL stePs finaLly have dEmonsTRated that it is pOSsible to enginEEr TISsUE thaT caN help patienTs."

TiSSue eNginEErIng HAs focUsed pRiMArILy on repair: burned skiN, mUscle sHorn oFf during in an aCcident, a dySFUNctional BladDEr. rEcent advances gO beyoNd repair to REplacemeNt.

One Of the two New studieS INvolves a GroUp oF foUr tEENaGe patients borN WIth a RaRe condiTioN called mayEr-ROkiTanSkY-Küster-HaUser SyndRoMe. thE pAtiEnts hAD either a MiSsiNg Or dEformED uteruS, an abSent Or IlL-ForMed vagiNA, oR SOme oThEr DysfUncTiOn.

The ProcESs fOr recreAting theiR rePRoduCtIvE systemS sounds deceptIvEly simple.

IT bEgiNs with SCIentists Creating a 3-D scaffold that mIRrors thE diMensiOns oF the patieNts' MissinG orGAns. TheY then tAke smAlL swATChes oF MUsCle AnD tissue froM THe pAtienTs, And eXtract cElls.

Those cells are tHEn uSed to "seed" (or spReaD acrOSS) vAriOUs SUrfAcES of THE 3-D scaffolds, wherE they grow fOr A FeW weeks outsIDe tHe Body.

"ThiS is not lIke a dEFective Organ that You augmenT oR somETHinG you put in bEtween twO places," saID Dr. AnTHoNy AtaLa, dIrectoR oF thE Wake forest iNstItute For RegEnErativE MediCiNe and leaD author of the vaginal orgaN study. "we had To cReate the oRgaN. we pUt it in de nOvo (aNew)."

Organ scAffOldS servE muLTiple PurpOSeS: ThEY provIde a FRamework uPOn WhiCH ThE new organ caN GROw. THey alSo aRE made
, as well as this Sakuga B log. Thank s toeve ryo ne  who ’s h elped out so f a r!
Become a Patron! Story  high li g htsS ci entis ts grow re p r odu ct iv e o rg a ns  andnas al cart ilage

Bot h a re  successfull y  i mplanted i n p atients

Org ans  are m ad e w i th sc aff oldsthat,o ver ti me, meltin t o theb ody

Co m p li cati ons among patient s  h a ve been virtua lly no ne x is t e nt
Tw o body par ts . One scienti f ic l e ap. 
Scientists i n the Unite d  St ates,Me xic o  and S witze rl a ndgrew reprod ucti ve organs  and n a sal car t ilage i n labs , a ndsucc e ss fu lly  i m pla n te d t h emin patie nt s,  acco rdin g t o  two  st udie s rel eased in TheLan ceto n T hursd ay.
It i snot t he fir st ti me  scientists hav e en gineeredbod ypar ts  -- i n  effec t,cre ating o rgans w h ere  b e f o re  there were none.Wh a t  i s differ ent in th es e  cases i sthe  siz e and c ompl e xi ty of th e orga n s. 
"This i sa move  f orw ard  to e v en m ore ch allengin g (or g ans)," said Iv a n Martin, a p r of e s so r  oftis sue enginee ring at U nive r si tyH ospit al Ba se l  i n  Switzerland, and c o- author  of t he nasal cart ilage stud y . 
"All th esei nc r emental stepsfinal ly have de m onstrate d tha t it ispossiblet o  enginee r t iss uetha t ca n help patien t s ."
Ti ssue en gin eeringhas  fo cus edpr imarily o n repair :bu rn ed  sk in, m u scle sho rn  of fdur ing i n  an ac ciden t, a  d ys f unc tionalb la d d er.Re ce nt a dva nc es go  bey o ndrepairto replac eme n t.
On eof thetwo new studi es  involvesagro up off o ur teena ge patients born with a rare co ndi tioncall ed Mayer- Rok itansk y-K ü ster-H auserSyndr om e.T h e pat i e nt s h ad  either am i ssi ng or  d efor med ute rus, an absent ori ll- formed vagina , o r so m e  o the r  d y sfu nc t ion . 
The process fo r recreati ng th eir reprod u cti ve  system s sound s dec e ptively  simple.
It begin swith s cie ntists cre ating a3-D scaff o ld th a tmirro rsthe di me nsi ons o f thep ati ents'  missi ng  organ s. Th ey  then ta ke small swatches of mu scle a nd ti ssu e from th e p a tie nts, andextr act cells. 

T hos e cel lsa re th en u s ed  to "seed " (o r  spread a c ro ss) v ar ious surfac e s ofthe 3 -Ds caffol ds,where they grow f o r a few weeksouts i d e t heb ody. 
"This is not l ike  a d efective  o rgan that y ou augme nt or so methin g youput inb e tw e en two  pla ces ," said D r.An t hony At al a, direct or o fthe Wa ke For e st I n s titute for Regen erati v e  Medi c ine  andle ad auth o r of  the vagin al organ st udy. " We h ad to  create  t he org an.  W e put it i n  de novo(anew )."

Or ga n sc aff olds s erve m ultip le p ur pos es: Theyp r ov i de  a fra mewo rk up on  whi ch the ne w  organ c ang row. Th ey  al s o  are m a de 
, as_well as_this Sakuga Blog. Thanks_to everyone_who’s_helped out_so_far!

Become a Patron!_Story highlights Scientists_grow reproductive organs and_nasal cartilage

Both are_successfully_implanted in patients

Organs are made with scaffolds that, over time, melt into the body

Complications_among_patients have_been_virtually_nonexistent

Two body parts. One scientific_leap.

Scientists in the United States,_Mexico and_Switzerland grew reproductive organs and nasal cartilage in_labs,_and successfully implanted_them in patients, according to two studies released in_The Lancet on Thursday.

It is not_the first time_scientists_have_engineered body parts --_in effect, creating organs where before_there were none. What is different_in these cases is the size and_complexity of the organs.

"This is a_move forward to even more_challenging (organs),"_said Ivan Martin, a professor_of tissue engineering_at University_Hospital Basel in_Switzerland, and co-author of the nasal_cartilage study.

"All these_incremental steps finally have demonstrated that_it_is possible to_engineer_tissue_that can_help patients."

Tissue engineering_has_focused primarily_on_repair: burned skin, muscle shorn off_during_in an accident, a dysfunctional bladder. Recent_advances go beyond repair_to_replacement.

One of the two_new studies involves a group_of four teenage patients born with_a rare_condition called_Mayer-Rokitansky-Küster-Hauser Syndrome. The patients had either a missing or deformed uterus,_an absent or ill-formed vagina, or_some other dysfunction.

The process_for recreating_their_reproductive systems sounds_deceptively_simple.

It begins_with scientists creating a 3-D scaffold that_mirrors the_dimensions of the patients' missing organs._They then take small_swatches_of muscle and tissue from the_patients, and extract cells.

Those cells are_then used to "seed" (or_spread_across)_various surfaces of the 3-D_scaffolds, where they grow for a_few weeks outside_the body.

"This is not like a defective_organ_that you augment or something you_put_in between two places," said Dr._Anthony_Atala,_director of the Wake Forest_Institute for Regenerative Medicine and lead_author of the vaginal organ study. "We had to_create the organ._We put it in de_novo_(anew)."

Organ_scaffolds serve multiple purposes: They provide a framework upon which_the new_organ can grow._They also are made