 the Major of Kymi and a medical doctor. His older brother, Naso, had studied law, so his father convinced George to continue in the family medical tradition. So George studied medicine, and did well, graduating with a degree in honours in 1904............"









Broad Ligament

The broad ligament is found associated with the internal human female genital tract. It forms a mesentery consisting of a double fold of the peritoneum that connects the uterus to the peritoneal floor and walls. Anatomically it has three parts: mesometrium - surrounding the uterus mesosalpinx - surrounding the uterine tube mesovarium - surrounding the ovary Abnormalities include peritoneal endometriosis.

Molecular

Wnt genes - Wnt4, Wnt5a, and Wnt7a implicated in the formation and morphogenesis of the M√ºllerian duct.

Wnt7a - mediates the patterning of the oviduct and differentiation of the uterus.

beta-catenin - manufactured in the mesenchyme is a downstream effector of Wnt7a.

Bmp2 - decidualization regulator of gene expression and function (shown in mouse uterus).

Lim1, Lhx9, Emx, Pax-2, Hox-A9, Hox-A10, Hox-A11, Hox-A13, WT1, SF-1, GATA-4. TGF-beta





References

↑ Abdom Radiol (NY),,. PMID: DOI. Pitot MA, Bookwalter CA & Dudiak KM. (2020). Müllerian duct anomalies coincident with endometriosis: a review.,. PMID: 32179978 ↑ Biol. Reprod.,,. PMID: DOI. Nanjappa MK, Mesa AM, Medrano TI, Jefferson WN, DeMayo FJ, Williams CJ, Lydon JP, Levin ER & Cooke PS. (2019). The histone methyltransferase EZH2 is required for normal uterine development and function in mice.,. PMID: 31201420 3.0 3.1 Cancer, 62, 2263-6. PMID: Parikh PM, Charak BS, Banavali SD, Koppikar SB, Giri N, Nadkarni P, Saikia TK, Gopal R & Advani SH. (1988). A prospective, randomized double-blind
the Major of Kymi and a medical doctor. His older brother, Naso, had study jurisprudence, so his father convinced George to retain in the family medical custom. So George studied medicine, and did well, graduate with a degree in honours in 1904............ " 









 Broad Ligament 

 The across-the-board ligament is found associated with the inner human female genital nerve pathway. It forms a mesentery consisting of a bivalent fold of the peritoneum that connect the uterus to the peritoneal floor and wall. Anatomically it has three parts: mesometrium - surrounding the uterus mesosalpinx - wall the uterine tube mesovarium - surrounding the ovary Abnormalities include peritoneal endometriosis. 

 Molecular 

 Wnt gene - Wnt4, Wnt5a, and Wnt7a implicated in the geological formation and morphogenesis of the M√ºllerian duct. 

 Wnt7a - mediates the patterning of the oviduct and differentiation of the uterus. 

 beta - catenin - manufacture in the mesenchyme is a downstream effector of Wnt7a. 

 Bmp2 - decidualization regulator of gene expression and function (shown in mouse uterus). 

 Lim1, Lhx9, Emx, Pax-2, Hox - A9, Hox - A10, Hox - A11, Hox - A13, WT1, SF-1, GATA-4. TGF - beta 





 References 

 ↑ Abdom Radiol (NY), ,. PMID: DOI. Pitot MA, Bookwalter CA & Dudiak KM. (2020). Müllerian duct anomalies coincident with endometriosis: a review. ,. PMID: 32179978 ↑ Biol. Reprod. ,, . PMID: DOI. Nanjappa MK, Mesa AM, Medrano TI, Jefferson WN, DeMayo FJ, Williams CJ, Lydon JP, Levin ER & Cooke PS. (2019). The histone methyltransferase EZH2 is required for normal uterine development and function in mice. ,. PMID: 31201420 3.0 3.1 Cancer, 62, 2263 - 6. PMID: Parikh PM, Charak BS, Banavali SD, Koppikar SB, Giri N, Nadkarni P, Saikia TK, Gopal R & Advani SH. (1988). A prospective, randomized double - blind
 thf Major of Kymi and a meaical doctor. His older brothsr, Naso, fad studied law, so his fathec cobvinctb George to continue in the fwmily meeicao tradition. So Geornz stusled mzdmcine, and did wgll, graduatitg with a degrae iu honours in 1904............"









Broad Ligament

The broad ligamemt is found assosiattd rith nht internal human female genital tdact. It forms a mesemtery consisting of a doubpe flld of the peritonfum that cobnecew the uterus to the pegntoneal flokr and walls. Anatomically it har thrze parts: mewonetghum - surrouiding nhe uterus mesosalpinf - surrpunding the utcrine tuve mesovarium - surrouiding the ovary Abnotmalities hnelude peritoneal endonerrioshs.

Monecuuqr

Wvt feies - Wnt4, Ant5e, and Wnt7a jmplicated un the formation anc iirphogenesis kf the M√ºjlerian duct.

Wnt7a - mediates the patternitg kf the oviduct and diffwrentiation of the utgrus.

beta-caeenin - manufactured in the mesenchyme is a downstseam xfwecuov ud Ant7a.

Bmp2 - decidualization regulator of gene ex[dexspon and function (fhown in moisf ijerus).

Lim1, Lhx9, Eox, Pax-2, Hos-A9, Hox-A10, Hox-A11, Hox-A13, AT1, SF-1, GWTA-4. TTF-beta





Reftrencrs

↑ Abdom Radiol (NY),,. PMID: DOI. Pitot MA, Bojjwalter CA & Dudiak KM. (2020). Müllericn ducj anomslies coincident with eudometdiosis: a regiew.,. PMID: 32179978 ↑ Biol. Reprod.,,. PMKD: COH. Nanjapkx MK, Mesa AM, Medrwno TI, Jehferspn WN, DdMayp FJ, Wylliams CJ, Lydok JP, Levin ER & Cookf PS. (2019). Tve histone methyltransferase EZH2 is requicxd for normal uderpne develjpmenb and function yn mice.,. PMID: 31201420 3.0 3.1 Cancex, 62, 2263-6. PMKD: Parikh IM, Charak BS, Banavaly SD, Koppikar DB, Giri N, Navkarni P, Faikua TJ, Gopal F & Advani SH. (1988). S prospecnire, randomuzed double-blind
the Major of Kymi and a medical older Naso, had law, so his in family medical tradition. George studied medicine, did well, graduating with a degree honours in 1904............" Broad Ligament The broad ligament is found associated with the human female genital tract. It forms a mesentery consisting of a double fold the that the to the peritoneal floor and walls. Anatomically it has three parts: mesometrium - surrounding the uterus - surrounding the uterine tube mesovarium - surrounding ovary Abnormalities include peritoneal Molecular Wnt genes - Wnt4, and implicated in formation morphogenesis the M√ºllerian duct. - mediates the patterning of the oviduct and differentiation of the uterus. beta-catenin - manufactured in the is a of Wnt7a. - regulator gene expression and in mouse uterus). Lim1, Lhx9, Emx, Hox-A11, Hox-A13, WT1, SF-1, GATA-4. TGF-beta References ↑ Radiol (NY),,. DOI. Pitot MA, Bookwalter CA & KM. (2020). Müllerian duct anomalies coincident with endometriosis: review.,. PMID: 32179978 ↑ Biol. Reprod.,,. PMID: DOI. Nanjappa MK, Mesa AM, Medrano TI, Jefferson FJ, Williams CJ, Lydon Levin ER & PS. The methyltransferase is required normal uterine development and function in mice.,. PMID: 31201420 3.0 3.1 62, 2263-6. PMID: Parikh PM, Charak BS, Banavali SD, Koppikar N, P, Saikia TK, R & Advani SH. A randomized double-blind
 the Major of Kymi and a medical Doctor. His oLder bRotHer, naSo, haD stuDied law, so his faTHer cOnvinced George to continUe in tHe FAmilY MeDical TraditiON. SO gEorGe StUdiEd MEdIcine, And Did well, Graduating WitH a Degree in honoURs In 1904............"









Broad LigAmeNt

The broad liGamEnt is fOuNd aSSociaTed With tHe inteRNal humAn female gEnITal traCT. It formS A MeSentEry consisting of a dOUbLE fold of the periToneum ThAT cONNecTs tHe uterus to ThE periTOneal flOOr AND WalLS. Anatomically It has three pARts: MesomeTrIum - SUrrounDing tHe UTerUs mesosalpiNx - suRrounding The uteRIne tube MEsovariUm - surrOunDinG the OVaRy abnOrMAliTIeS inCLudE peritonEaL eNdomeTrioSIS.

mOlecUlaR

Wnt Genes - wnt4, Wnt5a, and Wnt7A imPlicATed In the FormaTion AnD morpHogeneSis of ThE M√ºllerian duct.

WNt7a - mEdiates thE paTtErnInG of thE OviducT anD diFferentIation oF The UtERUS.

bEta-catenin - manufactUrED In The mesenChyme iS A dOwNStream efFeCtoR of WNT7A.

Bmp2 - dEcidUAlIzation rEgulatOR oF gEne exprEsSion anD fUncTioN (showN In moUse uteRus).

Lim1, LhX9, Emx, PAX-2, Hox-A9, Hox-A10, Hox-A11, HOX-A13, WT1, SF-1, GATA-4. TGF-BEtA





rEfERencEs

↑ ABdom Radiol (Ny),,. PMId: dOI. PItot ma, BOokWAlter cA & DudIaK kM. (2020). mÜllerian duct anomaliEs CoinciDent wIth endometrioSis: a review.,. pmid: 32179978 ↑ Biol. RepRod.,,. PmiD: doI. Nanjappa MK, MeSa AM, MEdrano TI, JeFFerson WN, deMayO FJ, WilliAms CJ, LydoN jp, Levin ER & cooKe Ps. (2019). ThE hiSTOnE methyltransfERAse EzH2 Is requiRed For normAl uTerIne DevElOpment and Function In MiCe.,. pMiD: 31201420 3.0 3.1 CAncer, 62, 2263-6. pmID: ParikH Pm, ChArAk Bs, BanaVAli SD, KOppikAr SB, giRi n, nadKarni P, SAIkIA tK, GoPaL R & advaNi Sh. (1988). A ProspEctiVE, raNdomizeD double-blInd
 the Major of Kymi and a m edical doc tor.His  ol de r br othe r, Naso, had s t udie d law, so his father c onvin ce d  Geo r ge  to c ontinue in t hefa mi lyme d ic al tr adi tion. S o George s tud ie d medicine,a nd  did well,  gr aduating wit h a  degre einh onour s i n 190 4..... . ...... "







B road L i gamentT he  bro ad ligament is fo u nd associated wit h thein t er n a l h uma n female g en italt ract. I t  f o r m s a mesentery con sisting ofa  do uble f ol d o f  the p erito ne u m t hat connect s th e uterusto the periton e al floo r andwal ls.  Ana t om ic all yi t h a sthr e e p arts: me so me trium  - s u r r o undi ngtheuteru s mesosalpinx  -surr o und ing t he ut erin etubemesova rium-surrounding the  ova ry Abnorm ali ti esin clude perito nea l e ndometr iosis.Mol ec u l a r
Wnt genes - Wnt4,  W n t 5a , and Wn t7a im p li ca t ed in th efor mati o n  andmorp h og enesis o f theM √º ll erian d uc t.

Wn t7 a -  me diate s  the  patte rning of  theo viduct and dif f erentiation o f  t h e  u t erus .
beta-cateni n -m anuf actu r ed  in the m esenc hy m ei s a downstream effe ct or ofWnt7a .

Bmp2 - dec idualizati o n regulato r of ge n e expression a nd fu nction (sh o wn in mo use u terus).
Lim1, Lh x 9 , Emx, P ax- 2,Hox -A9 , Ho x-A10, Hox-A1 1 ,  Hox -A 13, WT1 , S F-1, GA TA- 4.TGF -be ta 





Ref erences
↑  A bd om  Ra diol( NY),,. P MI D:DO I.Pitot MA, Bo okwal terCA  & Dud iak KM. (2 0 2 0).Mü ll eria n d uc t ano mali e s c oincide nt with e ndo m etri os is : a rev iew.,. PMID:32 179978 ↑ B io l.Reprod . , ,. PMID:  DOI. Nanjappa MK, Mesa AM, Med ran o TI,  Jef ferson WN , D eMayoFJ, Willia ms CJ,  Lydo nJP, L evinE R  &  Co ok e PS. (201 9 ) . T he hi st onemethylt ransferase EZH2 is req uired for nor mal  ute r i ne  de v el o pme nt and f unction in mice .,. PMID:31 2 01 420 3.0 3. 1  Ca nc er, 62,  2263-6 . PMI D : Parik h PM, Cha rak BS, B an aval i SD,  KoppikarSB, Giri  N, Nadka r ni P, Sa ikiaTK,  Gopal  R  &Advan i SH.( 198 8). A  prosp ec tive,rando mi zed doub le-blind
 the_Major of_Kymi and a medical_doctor. His_older_brother, Naso,_had_studied law, so_his father convinced_George to continue in_the family medical_tradition._So George studied medicine, and did well, graduating with a degree in honours in_1904............"









Broad_Ligament

The broad_ligament_is_found associated with the internal_human female genital tract. It_forms a_mesentery consisting of a double fold of the_peritoneum_that connects the_uterus to the peritoneal floor and walls. Anatomically it_has three parts: mesometrium - surrounding_the uterus mesosalpinx_-_surrounding_the uterine tube mesovarium_- surrounding the ovary Abnormalities include_peritoneal endometriosis.

Molecular

Wnt genes - Wnt4, Wnt5a,_and Wnt7a implicated in the formation and_morphogenesis of the M√ºllerian duct.

Wnt7a -_mediates the patterning of the_oviduct and_differentiation of the uterus.

beta-catenin -_manufactured in the_mesenchyme is_a downstream effector_of Wnt7a.

Bmp2 - decidualization regulator of_gene expression and_function (shown in mouse uterus).

Lim1, Lhx9,_Emx,_Pax-2, Hox-A9, Hox-A10,_Hox-A11,_Hox-A13,_WT1, SF-1,_GATA-4. TGF-beta





References

↑ Abdom_Radiol_(NY),,. PMID:_DOI._Pitot MA, Bookwalter CA & Dudiak_KM._(2020). Müllerian duct anomalies coincident with endometriosis:_a review.,. PMID: 32179978_↑_Biol. Reprod.,,. PMID: DOI._Nanjappa MK, Mesa AM, Medrano_TI, Jefferson WN, DeMayo FJ, Williams_CJ, Lydon_JP, Levin_ER & Cooke PS. (2019). The histone methyltransferase EZH2 is required_for normal uterine development and function_in mice.,. PMID: 31201420_3.0 3.1_Cancer,_62, 2263-6. PMID:_Parikh_PM, Charak_BS, Banavali SD, Koppikar SB, Giri N,_Nadkarni P,_Saikia TK, Gopal R & Advani_SH. (1988). A prospective,_randomized_double-blind