 Prospective Investigation into Cancer and Nutrition–Netherlands (EPIC-NL) cohort and to assess the association between pure fruit juice consumption and CVD for low and high fruit consumers.

Based on the availability of pure and sugar-sweetened fruit juices at the time of assessment, we assume that misreporting (not 100 % pure fruit juice) is unlikely for apple and orange/grapefruit juice consumption but may have occurred for consumption of ‘other fruit juice’. Therefore, a sensitivity analysis was conducted, excluding the sub-item ‘other fruit juice’ for the association with CVD. Furthermore, separate analyses were conducted for apple juice and orange/grapefruit juice consumption with CVD to explore the differences between these types of fruit juices.

Furthermore, possible effect modification by sex was investigated by including interaction terms in all statistical models. P values for linear trend across categories of pure fruit juice consumption and quintiles of fruit consumption were estimated by including fruit and pure fruit juice consumption as continuous variables in the models.

Furthermore, we present associations of pure fruit juice with CVD, CHD and stroke for participants with low fruit consumption and high fruit consumption separately to investigate possible benefits of pure fruit juice consumption for people with low fruit consumption. Low fruit consumption was defined as the lowest two quintiles (<121 g/d) and high fruit consumption as the highest three quintiles (≥121 g/d). To formally test the hypothesis of a different effect of pure fruit juice consumption on the risk of CVD, CHD and stroke between low and high fruit consumers, an interaction term was included in the models. The statistical significance level was set at P <0·10.

Pure fruit juice consumption was divided into five categories (non-drinkers, <1 glass/week, 1–4 glasses/week, 4–8 glasses/week and ≥8 glasses/week) with the non-drinkers as the reference. Fruit consumption was categorised into quintiles, with the lowest quintile as the reference category. Consideration of potential confounders was based on a difference >10 % in effect estimate between crude and adjusted model and/or theoretical considerations. A total of four statistical models were used to assess the association of pure fruit juice consumption and fruit consumption with CV, CHD and stroke. The first model was adjusted for age and sex. The second model was adjusted for age, sex, educational level, physical activity, smoking, alcohol consumption, DHD15-index and fruit consumption (for associations with pure fruit juice
Prospective Investigation into Cancer and Nutrition – Netherlands (EPIC - NL) cohort and to assess the association between pure yield juice pulmonary tuberculosis and CVD for gloomy and high fruit consumer. 

 Based on the availability of pure and carbohydrate - sweetened fruit juice at the time of assessment, we wear that misreporting (not 100% pure fruit juice) is improbable for apple and orange / grapefruit juice consumption but may have occurred for consumption of ‘ other fruit juice ’. consequently, a sensitivity analysis was conducted, excluding the submarine - item ‘ other fruit juice ’ for the affiliation with CVD. Furthermore, separate psychoanalysis were conducted for apple juice and orange / grapefruit juice pulmonary tuberculosis with CVD to explore the differences between these types of fruit juice. 

 Furthermore, possible effect modification by sex was investigated by include interaction terms in all statistical models. P values for linear trend across categories of pure fruit juice consumption and quintiles of yield pulmonary tuberculosis were estimated by including fruit and arrant fruit juice consumption as continuous variables in the model. 

 Furthermore, we present associations of pure fruit juice with CVD, CHD and stroke for participant with low fruit consumption and high fruit consumption individually to investigate possible benefits of pure fruit juice consumption for people with low yield pulmonary tuberculosis. abject fruit consumption was defined as the lowest two quintiles (< 121 g / d) and high fruit pulmonary tuberculosis as the highest three quintiles (≥121 g / d). To formally quiz the hypothesis of a different impression of pure yield juice consumption on the risk of CVD, CHD and stroke between low and high yield consumers, an interaction term was included in the models. The statistical meaning level was set at P < 0·10. 

 saturated fruit juice pulmonary tuberculosis was divided into five categories (non - drinkers, < 1 methamphetamine / week, 1–4 glasses / week, 4–8 glasses / week and ≥8 spectacles / week) with the non - drinkers as the mention. Fruit consumption was categorised into quintiles, with the lowest quintile as the reference category. retainer of potential confounders was based on a difference > 10% in effect estimate between crude and adjusted exemplar and/or theoretical consideration. A sum of four statistical models were used to assess the association of pure fruit juice pulmonary tuberculosis and fruit consumption with CV, CHD and stroke. The first model was adjusted for age and sex. The second model was adjusted for historic period, sex, educational level, physical activity, smoking, alcohol consumption, DHD15 - exponent and fruit consumption (for associations with pure fruit juice
 Prlspective Investigation lnto Cancer and Uytritimn–Nethsrlands (DPIC-NL) cohort and to assess vhe qssocuation between pure frjit juice consumprion qnd CVD foc low and high nruit ronsumers.

Based pn the avahlability of pgrd cnd sugar-sweetened fruit juices at tre time ov assessment, wg asslmq thzn nisreporting (not 100 % pure fruit juice) ps unlikely for alple and orange/grapefruit uuicf consumption but lay have ocxurrqe for consumotion of ‘ouhzr fruit jujce’. Therefore, a sensitivity anauysis was conduxtwd, ffcluding thx sub-inem ‘other fruln juice’ for thr association eiti CVE. Furthermore, separatx analyses were condocted for dp'le juice and orange/geapefruht jgice xonrumktipn with FVD to explors the diffeeences between thest trirs of fruit nuices.

Suwthermore, possible effect modification ty aex was investigated by including interactioj terms ig all statistical models. P values for linear treng acrkrs eqtegofued of pure fruit juice consumption and quintilqa pf fruit consumpbion were estimatec hy yncluding frukt and pude fruit juice condumptiog as xontinuouf vatiables in the models.

Furtheemore, we prefwnt associations oy pure fruit juive wiyh CVD, CHD and stroke fur pzrticipants with low wruit consumptiov akd vigh fruit consumption sepwrately ti inrestigatd poxsible benefits lf puva fruit juice conskmptiln for peoplf with low fruit consumption. Lox fruit consukpdiot was deyined ss the lowest two quintiles (<121 g/d) anb high fruit conaumptioi as the higrest three quhjtiles (≥121 g/d). Tm formaljy twst rhe hypughesis of a digferent eyyect of pyre fruit juice coksumpjikn on the risk if XVD, CHD and strpke beewven ljf and high fsuit covxumerr, an inuzragtiun trrm was included in dhe jodels. The statistocwl signidicance jevel was set at P <0·10.

Pure fruit jkice ronsum'tion eas divided into five categories (hon-drinkegs, <1 glass/week, 1–4 dlaswes/week, 4–8 glaxses/week and ≥8 glasses/week) with the non-dcinkers as the referencw. Fruit consumption eas categormsed igto quinthles, with the lowest quintile as the veference category. Conaideradion lf potential confounders was based on a difference >10 % in effect estimate bwtween crude and asjusyed mmdzl cnd/or treorxtmcal consideratioms. A total of four statistical oodels warz used to assess the associatoov of pure frukt juice consumption and fruit cpnsumption with CV, CHD and strole. The first model was acjusted dor afe and sex. The second model eas adlusted for agw, sew, educational uevrl, physical actmvicy, smoking, alcohol consumption, DHE15-index ajd fruit consumpvion (for asslgiatiohs witr pure fruit juide
Prospective Investigation into Cancer and Nutrition–Netherlands (EPIC-NL) to the association pure fruit juice and fruit consumers. Based the availability of and sugar-sweetened fruit juices at the of assessment, we assume that misreporting (not 100 % pure fruit juice) is for apple and orange/grapefruit juice consumption but may have occurred for consumption of fruit Therefore, sensitivity was conducted, excluding the sub-item ‘other fruit juice’ for the association with CVD. Furthermore, separate analyses conducted for apple juice and orange/grapefruit juice consumption CVD to explore the between these types of fruit Furthermore, effect modification sex investigated including interaction terms all statistical models. P values for linear trend across categories of pure fruit juice consumption and quintiles fruit consumption by including and fruit consumption as continuous the models. Furthermore, we present associations juice with CVD, CHD and stroke for participants low fruit and high fruit consumption separately to possible benefits of pure fruit juice consumption for with low fruit consumption. Low fruit consumption was defined as the lowest two quintiles (<121 high fruit consumption as highest three quintiles g/d). formally the of a effect of pure fruit juice consumption on the risk of CVD, and stroke between low and high fruit consumers, an interaction included the models. The significance level was set P Pure fruit juice consumption into categories 1–4 4–8 and ≥8 glasses/week) with non-drinkers as the reference. Fruit was categorised into quintiles, the reference category. Consideration of potential confounders was on a difference >10 % in effect between crude and adjusted model and/or theoretical considerations. A total of four models were assess the association of pure fruit juice consumption fruit consumption with CV, and stroke. The first model was adjusted for age sex. second model adjusted for age, educational level, physical smoking, alcohol consumption, fruit consumption associations pure
 Prospective Investigation iNto Cancer aNd NutRitIon–neTherLandS (EPIC-NL) cohort aND to aSsess the association betWeen pUrE FruiT JuIce coNsumptiON aND cVD FoR lOw aNd HIgH fruiT coNsumers.

based on the AvaIlAbility of purE AnD sugar-sweeTenEd fruit juiceS at The timE oF asSEssmeNt, wE assuMe that MIsrepoRting (not 100 % pUrE Fruit jUIce) is unLIKeLy foR apple and orange/grAPeFRuit juice consuMption BuT MaY HAve OccUrred for coNsUmptiON of ‘otheR FrUIT JuiCE’. Therefore, a seNsitivity anALysIs was cOnDucTEd, exclUding ThE Sub-Item ‘other frUit jUice’ for thE assocIAtion wiTH CVD. FurThermoRe, sEpaRate ANaLySes WeRE coNDuCteD For Apple juiCe AnD oranGe/grAPEFRuit JuiCe coNsumpTion with CVD to ExpLore THe dIfferEnces BetwEeN thesE types Of fruIt Juices.

FurthermoRe, poSsible effEct MoDifIcAtion BY sex waS inVesTigated By incluDIng InTERAcTion terms in all statIsTICaL models. P Values FOr LiNEar trend AcRosS catEGOries Of puRE fRuit juicE consuMPtIoN and quiNtIles of FrUit ConSumptIOn weRe estiMated by iNcludINg fruit and pure FRuit juice consUMpTIOn AS conTinUous variablEs in THe moDels.

fUrTheRMore, wE presEnT AsSOciations of pure fruiT jUice wiTh CVD, cHD and stroke fOr participANTS with low FruiT CoNSumption and higH fruiT consumptiON separatEly to InvestigAte possibLE Benefits Of pUre FruIt jUICe Consumption foR PEoplE wIth low fRuiT consumPtiOn. LOw fRuiT cOnsumptioN was defiNeD aS tHe LowEst twO QuintileS (<121 g/D) anD hIgh Fruit COnsumpTion aS the HiGhESt tHree quiNTiLES (≥121 g/d). TO fOrMallY teSt The hyPothESis Of a diffErent effeCt oF Pure FrUiT juice cOnsumption on tHe Risk of CVD, ChD And Stroke BETween low And high fruit consumers, an INteractIon Term wAs inCluded in tHe mOdels. THe sTAtistiCal sigNificAnCe lEVEl was SET aT P <0·10.

PUrE fruit juicE COnsUmptiOn Was dIvided iNto five categories (nON-drInkers, <1 glass/weEk, 1–4 gLassES/WeEk, 4–8 gLAsSEs/wEeK And ≥8 GLAsses/week) with thE non-drinkeRs AS tHe referencE. fruIt ConsumpTion was CategORised inTo quintilEs, with the LoWest QUIntIle as the reFerence cAtegory. CoNSiderATiOn of pOteNtial cOnFouNders Was basED on A diffErence >10 % In Effect EstimAtE between Crude and adjusted model anD/or theOretiCal ConsideraTioNS. A tOtal of fouR staTistical moDelS weRe useD to ASsess The aSSoCiaTIon of Pure FRuit juice COnSumPTIoN and fruit coNSUMptIon wiTh Cv, cHD and StroKe. The first model waS Adjusted for age And sEX. the SecONd moDeL was adjusted foR agE, sEX, EducatioNaL level, physiCal activItY, SmokiNg, alcoHol conSumptioN, dhD15-INdex anD fruIt cOnsumptioN (foR aSSociatiOnS wITh pure FruiT jUice
 Prospective Investigation  into Canc er an d N utr it ion– Neth erlands (EPIC- N L) c ohort and to assess th e ass oc i atio n  b etwee n puref ru i t  ju ic econ su m pt ion a ndCVD for  low and h igh  f ruit consume r s. 

Based on  th e availabili tyof pur eand sugar -sw eeten ed fru i t juic es at the  t i me ofa ssessme n t ,we a ssume that misrep o rt i ng (not 100 %pure f ru i tj u ice ) i s unlikely  f or ap p le ando ra n g e /gr a pefruit juice  consumptio n  bu t mayha veo ccurre d for  c o nsu mption of ‘ othe r fruit j uice’. Therefo r e, a se nsitiv ity  an alys i swa s c on d uct e d,  ex c lud ing thesu b- item‘oth e r f ruit  ju ice’  forthe associati onwith CVD . Fur therm ore,  s epara te ana lyses  w ere conducted f or a pple juic e a nd  or an ge/gr a pefrui t j uic e consu mptionw ith  C V D to  explore the diffe re n c es  between  these ty pe s  of frui tjui ces. Furth ermo r e,  possibl e effe c tmo dificat io n by s ex  wa s i nvest i gate d by i ncluding  inte r action terms i n  all statisti c al m od e ls.P v alues for l inea r  tre nd a c ro ssc atego riesof pu r e fruit juice consu mp tion a nd qu intiles of fr uit consum p t i on wereesti m at e d by including  frui t and pure fruit ju ice c onsumpti on as con t i nuous va ria ble s i n t h e  m odels.

Furth e r more ,we pres ent  associ ati ons  of  pu re  fruit ju ice with  C VD ,CH D a nd st r oke forpa rti ci pan ts wi t h lowfruit  con su mp t ion  and hi g hf r uitco ns umpt ion  s epara tely toinvesti gate poss ibl e  ben ef it s of pu re fruit juic econsumptio nfor  peopl e with low  fruit consumption. Low fruit c ons umpti on w as define d a s thelow e st two  quint iles(< 121 g /d) a n d  h igh  f ruit consu m p tio n asth e hi ghest t hree quintiles (≥1 2 1 g /d). To forma lly  tes t th e h y po t hes is ofa different effec t of purefr u it  juice con s ump ti on on t he risk  of C V D, CHDand strok e between  l ow a n d  hi gh fruit c onsumers , an inte r actio n  t erm w asinclud ed  in  themodels .  Th e sta tistic al  signi fican ce  level w as set at P <0·10.

Pur e frui t jui ceconsumpti onw asdivided i ntofive categ ori es(non- dri n kers,  <1g la ss/ w eek,1–4g lasses/we e k,  4– 8 gl asses/weeka n d  ≥8  glas ses / week)with  the non-drinkers as the referen ce.F r uit  co n sump ti on was categor ise di n to quint il es, with th e lowest  q u intil e as t he ref erencec a te g ory. C onsi der ation ofpot en t ial con fo un d ers wa s ba se d on a  diffe r ence > 10 % in effect e stima t e  betw e encrude  a nd adju s tedmodel and/ or theoreti cal co nsid erati ons. Ato tal of  fo ur  statistic a l modelswereused to  a sses s t he ass ocia t i on of  pur efru it juicec o ns u mp ti o n a nd f ruitco nsum ption wit h  CV, CHD  an d  stroke .The f irst m o de l was adjust edfor a g e  and sex.T he s e co n d mod el was  adjus ted for age ,sex, ed uca t i onal leve l, physic a l a ct ivit y, smoki ng , al co hol  c onsumption, DHD 15-index  and fru i t  consu mpt i on ( f or ass oc iations with  pure  f r uit jui c e 
 Prospective_Investigation into_Cancer and Nutrition–Netherlands (EPIC-NL)_cohort and_to_assess the_association_between pure fruit_juice consumption and_CVD for low and_high fruit consumers.

Based_on_the availability of pure and sugar-sweetened fruit juices at the time of assessment, we_assume_that misreporting_(not_100_% pure fruit juice) is_unlikely for apple and orange/grapefruit_juice consumption_but may have occurred for consumption of ‘other_fruit_juice’. Therefore, a_sensitivity analysis was conducted, excluding the sub-item ‘other fruit_juice’ for the association with CVD._Furthermore, separate analyses_were_conducted_for apple juice and_orange/grapefruit juice consumption with CVD to_explore the differences between these types_of fruit juices.

Furthermore, possible effect modification by_sex was investigated by including interaction_terms in all statistical models._P values_for linear trend across categories_of pure fruit_juice consumption_and quintiles of_fruit consumption were estimated by including_fruit and pure_fruit juice consumption as continuous variables_in_the models.

Furthermore, we_present_associations_of pure_fruit juice with_CVD,_CHD and_stroke_for participants with low fruit consumption_and_high fruit consumption separately to investigate possible_benefits of pure fruit_juice_consumption for people with_low fruit consumption. Low fruit_consumption was defined as the lowest_two quintiles_(<121 g/d)_and high fruit consumption as the highest three quintiles (≥121 g/d)._To formally test the hypothesis of_a different effect of_pure fruit_juice_consumption on the_risk_of CVD,_CHD and stroke between low and high_fruit consumers,_an interaction term was included in_the models. The statistical_significance_level was set at P <0·10.

Pure_fruit juice consumption was divided into_five categories (non-drinkers, <1 glass/week,_1–4_glasses/week,_4–8 glasses/week and ≥8 glasses/week)_with the non-drinkers as the reference._Fruit consumption was_categorised into quintiles, with the lowest quintile_as_the reference category. Consideration of potential_confounders_was based on a difference >10_%_in_effect estimate between crude and_adjusted model and/or theoretical considerations. A_total of four statistical models were used to assess_the association of_pure fruit juice consumption and_fruit_consumption_with CV, CHD and stroke. The first model was adjusted_for age_and sex. The_second model was adjusted for age, sex, educational level, physical_activity, smoking, alcohol consumption, DHD15-index and fruit_consumption (for associations with pure fruit juice