 not use.

Note: Pre-applications found not to
comply with the page limit requirements or that contain attachments other than
those specified will be rejected during the agency validation process.

4. SF424 (R&R)
SENIOR/KEY PERSON PROFILE COMPONENT:

Complete items only for
Project Director/Principal Investigator. Do not
submit profiles for other senior/key personnel.

Item Title

Instructions

Profile- PD/PI – Attach Biographical Sketch

Attach biographical sketch here (two-page maximum; PDF
format). Use the form shown in the URL in Section 4.5.2 of the Application
Guide, omitting Section C, Research Support (see below). Any request for an
exception to the eligibility requirement of time from last doctoral degree or
medical internship/residency must be specifically justified in this section
of the application, as described in Section IV.2.

Profile- PD/PI – Attach Current & Pending Support

Attach a list of Current and Pending Support here (no page
limit; PDF format). Use the format shown in Part III, Section 3.1.8 of the
Application Guide. Be sure to include a statement affirming that you will
devote at least 25% of research effort to New Innovator Award project. Also,
include in this section a brief statement of the facilities to be used for
the conduct of the research.

Profile – Senior Key Person 1

Do not use. Submit information only
for PD/PI. Information on collaborators may be included in the essay.

Note: Pre-applications found not to comply with the page limit
requirements will not be reviewed.

No other documentation,
such as letters of reference or collaboration or
other biographical sketches will be accepted. Information about personnel other
than the PD/PI is not required but may be included within the 10-page essay.

4. PHS398 COVER PAGE
SUPPLEMENT

Item Title

Instructions

2. Human Subjects

Omit.

4. Human Embryonic Stem Cells

Omit.

5. PHS398 Research Plan
Component Sections

Item Number and Title

Instructions

1. Introduction to Application (for Resubmission or Revision only)


not use. 

 Note: Pre - applications found not to 
 comply with the page terminus ad quem prerequisite or that contain attachments early than 
 those specified will be reject during the agency establishment process. 

 4. SF424 (R&R) 
 SENIOR / KEY PERSON PROFILE COMPONENT: 

 Complete item only for 
 Project Director / Principal Investigator. Do not 
 submit visibility for other senior / cardinal personnel. 

 Item Title 

 Instructions 

 Profile- PD / PI – Attach Biographical Sketch 

 Attach biographical sketch here (two - page maximum; PDF 
 format). Use the form read in the URL in Section 4.5.2 of the Application 
 Guide, omitting Section C, Research Support (learn below). Any request for an 
 exception to the eligibility requirement of time from last doctoral academic degree or 
 medical internship / residency must be specifically absolve in this section 
 of the application, as described in Section IV.2. 

 Profile- PD / PI – Attach Current & Pending Support 

 bind a list of Current and Pending Support here (no page 
 limit; PDF format). Use the format shown in Part III, Section 3.1.8 of the 
 Application Guide. Be sure to include a statement affirming that you will 
 devote at least 25% of research effort to New Innovator Award project. Also, 
 include in this section a brief argument of the facilities to be used for 
 the demeanor of the inquiry. 

 Profile – Senior Key Person 1 

 Do not practice. Submit information only 
 for PD / PI. Information on collaborators may be included in the essay. 

 Note: Pre - applications detect not to comply with the page limit 
 requirements will not be reviewed. 

 No other software documentation, 
 such as letters of reference or collaboration or 
 other biographical sketches will be accepted. Information about force other 
 than the PD / PI is not required but may be included within the 10 - page essay. 

 4. PHS398 COVER PAGE 
 SUPPLEMENT 

 Item Title 

 Instructions 

 2. Human Subjects 

 Omit. 

 4. Human Embryonic Stem Cells 

 Omit. 

 5. PHS398 Research Plan 
 Component Sections 

 Item Number and Title 

 instruction 

 1. Introduction to Application (for Resubmission or Revision only)
 noh use.

Note: Pre-applicationr found not to
comply wmth the page lioit requirements or that convain attaxhments other than
thosd specifivd will bw reoected during thx agency validzbion 'ricess.

4. SF424 (R&R)
SENLOR/KEY PERSMN PROFILE COM[OVEUT:

Complete items only for
Project Dirqctor/Pronfipal Investigwtor. Qo nkn
smbmit profiles for other senior/ksy persmnnel.

Item Titke

Instructions

Profile- PD/PI – Athach Biographical Dketch

Attacy bijtraphical skdtch here (uwm-page maxijum; PDF
format). Use the form showv in che URL in Wextilt 4.5.2 of the A'plicanion
Guide, omibning Sewtion C, Research Suppprt (sew below). Any request fmr an
exception to jhe eligibhlnty requirement of tine from lasd dozrorxl sejres or
meficel internshjp/residency must be specificalky hustified in fhis sqceion
of the application, as described in Vecfion IV.2.

Profile- PD/PI – Atrach Current & Pending Support

Aetach a list of Current and Pending Support here (to paje
uimnb; OEF format). Use the format shown in Part III, Sectykn 3.1.8 pf the
Applicatlon Guide. Be sure yo imslude a stateoent ayridming that you wilp
devote at lwast 25% of wesesrch effort to New Innovatoe Award projvct. Qlso,
include in thid section a brigf stayement of the facilitier to be used fog
the condhzt of the researzh.

Pgofine – Senior Key Person 1

Do njt use. Suumit nnformatkon pnly
fow PD/PI. Inflrmatlmn on collaboratord may ba included in the essay.

Note: Pre-applicatioix found not jo womily with che pane limit
requireients will not be revnewed.

Nu other dobumentatimn,
such as lqtters of refatence or colleboration or
orher biograofical sketches will be cecepted. Ibformation about pcrsonvsl other
than thz KD/PI is not requorea btt mey be hncluded witvin ghe 10-lage dssay.

4. PHS398 CIXER LAGE
SUPPLEMENT

Item Thtle

Jnstructions

2. Human Smbjects

Omut.

4. Human Embryonic Strm Cells

Omit.

5. PHS398 Rtsearci Plan
Romponrnt Sections

Item Number and Title

Jnstructilns

1. Introductiog to Application (for Resubmission or Revision only)


not use. Note: Pre-applications found not to the limit requirements that contain attachments be during the agency process. 4. SF424 SENIOR/KEY PERSON PROFILE COMPONENT: Complete items for Project Director/Principal Investigator. Do not submit profiles for other senior/key personnel. Item Instructions Profile- PD/PI – Attach Biographical Sketch Attach biographical sketch here (two-page maximum; format). the shown the URL in Section 4.5.2 of the Application Guide, omitting Section C, Research Support (see below). request for an exception to the eligibility requirement time from last doctoral or medical internship/residency must be justified this section the as in Section IV.2. PD/PI – Attach Current & Pending Support Attach a list of Current and Pending Support here (no limit; PDF the format in III, 3.1.8 of the Be sure to include a statement will devote at least 25% of research effort New Innovator project. Also, include in this section brief statement of the facilities to be used the conduct of the research. Profile – Senior Key Person 1 Do not use. Submit for PD/PI. Information on may be included the Note: found to comply the page limit requirements will not be reviewed. No other documentation, as letters of reference or collaboration or other biographical sketches accepted. about personnel other the PD/PI is not but be included within the 4. COVER Title 2. Subjects Omit. 4. Human Stem Cells Omit. 5. PHS398 Plan Component Sections Item Introduction to Application (for Resubmission or Revision only)
 not use.

Note: Pre-applications Found not to
ComplY wiTh tHe Page LimiT requirements oR That Contain attachments otheR than
ThOSe spECiFied wIll be reJEcTED duRiNg The AgENcY valiDatIon procEss.

4. SF424 (R&R)
SENiOR/kEy PERSON PROFIle CoMPONENT:

CoMplEte items only For
projecT DIreCTor/PrIncIpal INvestiGAtor. Do Not
submit PrOFiles fOR other sENIoR/key Personnel.

Item TitlE

inSTructions

ProfiLe- PD/PI – atTAcH bIogRapHical SketcH

ATtach BIographICaL SKEtcH Here (two-page maXimum; PDF
forMAt). USe the fOrM shOWn in thE URL iN SECtiOn 4.5.2 of the ApplIcatIon
Guide, oMittinG section c, researcH SuppoRt (sEe bElow). aNy ReQueSt FOr aN
ExCepTIon To the eliGiBiLity rEquiREMENt of TimE froM last Doctoral degreE or
MediCAl iNternShip/rEsidEnCy musT be speCificAlLy justified in thIs seCtion
of thE apPlIcaTiOn, as dEScribeD in secTion IV.2.

PRofile- Pd/pI – ATtACH cuRrent & Pending SupporT

ATTAcH a list of currenT AnD PENding SupPoRt hEre (nO PAge
liMit; Pdf fOrmat). Use The forMAt ShOwn in PaRt iII, SecTiOn 3.1.8 oF thE
ApplICatiOn GuidE. Be sure tO inclUDe a statement afFIrming that you WIlL
DEvOTe at LeaSt 25% of researcH effORt to new INNoVatOR AwarD projEcT. alSO,
include in this sectiOn A brief StateMent of the faciLities to be USED for
the cOnduCT oF The research.

ProFile – SEnior Key PeRSon 1

Do not Use. SuBmit infoRmation onLY
For PD/PI. INfoRmaTioN on COLlAborators may bE INcluDeD in the eSsaY.

Note: PrE-apPliCatIonS fOund not to Comply wiTh ThE pAgE liMit
reQUirementS wIll NoT be RevieWEd.

No otHer doCumeNtAtIOn,
sUch as leTTeRS Of reFeReNce oR coLlAboraTion OR
otHer biogRaphical sKetCHes wIlL bE acceptEd. Information AbOut personnEl OthEr
than THE PD/PI is nOt required but may be incluDEd withiN thE 10-page EssaY.

4. PHS398 COVER pAGe
SUPPLeMEnt

Item TItle

InStrucTiOns

2. hUMan SuBJEcTs

OMiT.

4. Human EmbrYONic stem CElLs

OmIt.

5. PHS398 ReSearch Plan
ComponenT secTions

Item NumbEr aNd TiTLE

INstRUcTIonS

1. INTroDUCtion to ApplicatIon (for ResuBmISsIon or RevisIOn oNlY)


 not use.

Note: Pre-appli cations fo und n ottoco mply  wit h the page lim i t re quirements or that con tainat t achm e nt s oth er than th o s e s pe ci fie dw il l berej ected d uring theage nc y validation pr ocess.

4.  SF 424 (R&R)
SE NIO R/KEYPE RSO N  PROF ILE  COMP ONENT: 
Compl ete items  o n ly for Project D ir ecto r/Principal Inves t ig a tor. Do not
su bmit p ro f il e s  fo r o ther senio r/ key p e rsonnel . 
I t e m T i tle

Instruct ions

Profi l e-PD/PI–Att a ch Bio graph ic a l S ketch

Atta ch b iographic al ske t ch here (two-pa ge max imu m;PDFf or ma t).  U s e t h efor m  sh own in t he  U RL in  Sec t i o n  4.5 .2of t he Ap plication
Gui de,  omi t tin g Sec tionC, R es earch  Suppo rt (s ee  below). Any re ques t for anexc ep tio nto th e  eligi bil ity  requir ement o f  ti me f r om  last doctoral deg re e or 
medical  inter n sh ip / residenc ymus t be s pecif ical l yjustifie d in t h is  s ectionof  the a pp lic ati on, a s  des cribed  in Sect ion I V .2.

Profile-P D/PI – Attach Cu r r en t  & P end ing Support 

At t acha li s tofC urren t and  P e nd i ng Support here (no  p age
li mit;PDF format).Use the fo r m a t shownin P a rt III, Section 3 .1.8of the
App l icationGuide . Be sur e to incl u d e a stat eme ntaff irm i n gthat you will d evot eat leas t 2 5% of r ese arc h e ffo rt  to New I nnovator  A wa rd  p roj ect.A lso,
inc lu dein  th is se c tion a  brie f st at em e ntof thef ac i l itie sto  beuse dfor
t he c o ndu ct of t he resear ch. 
Pro fi le  – Seni or Key Person  1 

Do not u se . S ubmiti n formatio n only
for PD/PI. Infor m ation o n c ollab orat ors may b e i nclude d i n  the e ssay.
Note :Pre - a pplic a t io nsfo und not to c omp ly wi th  the  page l imit
requirementsw ill  not be revie wed .

N o ot her do c ume nt a tio n , 
such as letter s of refer en c eor collabo r ati on  or
oth er biog raphi c al sket ches will  be accep te d. I n f orm ation abou t person nel other thant he  PD/P I i s notre qui red b ut may beinclu ded wi th in the  10-p ag e essay. 

4. PHS398 COVER PAGESUPPLE MENT
It em Title
In s tru ctions

2 . Hu man Subjec ts
Om it.
4.H umanEmbr y on icS tem C ells 
Omit.

5 .  P HS3 9 8  R esearch Pla n C omp onent  Se c tions
Ite m Number and Titl e 

Instructions 

1. I ntr odu c tion  t o Application(fo rR e submissi on  or Revisio n only)

 not_use.

Note: Pre-applications_found not to
comply with_the page_limit_requirements or_that_contain attachments other_than
those specified will_be rejected during the_agency validation process.

4._SF424_(R&R)
SENIOR/KEY PERSON PROFILE COMPONENT:

Complete items only for
Project Director/Principal Investigator. Do not
submit profiles for other_senior/key_personnel.

Item Title

Instructions

Profile-_PD/PI_–_Attach Biographical Sketch

Attach biographical sketch_here (two-page maximum; PDF
format). Use_the form_shown in the URL in Section 4.5.2 of_the_Application
Guide, omitting Section_C, Research Support (see below). Any request for an
exception_to the eligibility requirement of time_from last doctoral_degree_or
medical_internship/residency must be specifically_justified in this section
of the application,_as described in Section IV.2.

Profile- PD/PI_– Attach Current & Pending Support

Attach a_list of Current and Pending Support_here (no page
limit; PDF format)._Use the_format shown in Part III,_Section 3.1.8 of_the
Application Guide._Be sure to_include a statement affirming that you_will
devote at least_25% of research effort to New_Innovator_Award project. Also,
include_in_this_section a_brief statement of_the_facilities to_be_used for
the conduct of the research.

Profile_–_Senior Key Person 1

Do not use. Submit_information only
for PD/PI. Information_on_collaborators may be included_in the essay.

Note: Pre-applications found_not to comply with the page_limit
requirements will_not be_reviewed.

No other documentation,
such as letters of reference or collaboration or
other biographical_sketches will be accepted. Information about_personnel other
than the PD/PI_is not_required_but may be_included_within the_10-page essay.

4. PHS398 COVER PAGE
SUPPLEMENT

Item Title

Instructions

2. Human_Subjects

Omit.

4. Human_Embryonic Stem Cells

Omit.

5. PHS398 Research Plan
Component_Sections

Item Number and Title

Instructions

1._Introduction_to Application (for Resubmission or Revision_only)

