 response to this FOA. Through the associated FOA (RFA-RM-09-003),
NIH expects to commit approximately $55.7 million for the five-year
period. It is anticipated that up to 24 awards will be made in 2009.

Budget and Project Period.No awards will be made under this
announcement. Awards through RFA-RM-09-003 will be for up to $300,000 in direct costs each year for five years, plus
applicable Facilities and Administrative costs, which will be determined
at the time of award.

Eligible
Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources
necessary to carry out the proposed research are invited to work with
their institution/organization to develop a pre-application for support. Women and individuals from underrepresented racial and ethnic groups as well
as individuals with disabilities are always encouraged to apply for NIH
support. Investigators (PD/PIs)
must hold an independent research position at a domestic (U.S.)
institution as of September 19, 2009 and must have received their most
recent doctoral degree (e.g., Ph.D., M.D., D.D.S., D.V.M., PharmD, or
equivalent) or completed their medical internship and residency no earlier
than 1999 and no later than the due date for pre-applications. For the
purpose of this FOA, “independent research position” means a position that
automatically confers eligibility by the researcher’s institutional policy
for an investigator to apply for R01 grants, with an appropriate
commitment of facilities to be used for the conduct of the proposed
research. Investigators still in training or mentored status (postdoctoral
fellows) are not eligible to apply unless they have a written commitment
of an independent faculty position as of September 19, 2009; submission of
the pre-application from that institution serves as the written commitment
of an independent faculty position.

PDs/PIs must meet the
definition of “new investigator.” For the purpose of this FOA, “new
investigators” are defined as those PDs/PIs who have never been awarded an R01
or equivalent NIH grant (e.g., R23, R29, R33, R37, DP1, DP2, U01, P01
response to this FOA. Through the associated FOA (RFA - RM-09 - 003), 
 NIH expects to commit approximately $ 55.7 million for the five - class 
 time period. It is anticipated that up to 24 awards will be make in 2009. 

 Budget and Project Period. No award will be made under this 
 announcement. Awards through RFA - RM-09 - 003 will be for up to $ 300,000 in lineal costs each year for five years, plus 
 applicable Facilities and Administrative cost, which will be determined 
 at the time of prize. 

 Eligible 
 Project Directors / Principal Investigators (PDs / PIs). Individuals with the skills, knowledge, and resource 
 necessary to carry out the proposed research are invited to work with 
 their initiation / organization to develop a pre - application for accompaniment. Women and individuals from underrepresented racial and ethnic groups equally well 
 as individuals with disability are always encouraged to apply for NIH 
 support. investigator (PD / PIs) 
 must hold an independent research position at a domestic (U.S.) 
 initiation as of September 19, 2009 and must have received their most 
 recent doctoral degree (e.g., Ph.D., M.D., D.D.S., D.V.M., PharmD, or 
 equivalent) or completed their medical internship and residency no earlier 
 than 1999 and no later than the due date for pre - applications. For the 
 function of this FOA, “ independent research stead ” means a position that 
 automatically confers eligibility by the research worker ’s institutional policy 
 for an investigator to use for R01 grants, with an appropriate 
 commitment of facility to be used for the conduct of the proposed 
 research. investigator still in training or mentored status (postdoctoral 
 fellows) are not eligible to put on unless they get a write commitment 
 of an independent faculty stead as of September 19, 2009; submission of 
 the pre - application from that institution serve as the written commitment 
 of an independent faculty situation. 

 PDs / PIs must suffer the 
 definition of “ new investigator. ” For the function of this FOA, “ new 
 research worker ” are defined as those palladium / PIs who have never been awarded an R01 
 or equivalent NIH concession (e.g., R23, R29, R33, R37, DP1, DP2, U01, P01
 redponse to this FOA. Throunh the associateb FOA (RHA-RM-09-003),
NIH expects to commit approximately $55.7 mipluon fir the five-year
period. Kt is antpcipated rhat yp to 24 awacss will be masc in 2009.

Yuvget and Projecj Period.No afards will be kaae under this
announcement. Awards throtgh RFA-TM-09-003 will be for uk to $300,000 yn djgegt costs each year for five yeara, plus
akplicable Facilitirs and Administrative costd, whlch will be determlned
at the jjme if award.

Eligkble
Projecu Birectors/Prjncipal Investigators (PDs/PIs). Inaividbals with tye sklnls, knowledje, and resources
negvssary do carru out the proppsev rewearch are invited to work with
their inftitution/mryanization to develop a pre-akplicdtiov fof shp'orf. Womej aid individuzls from uneerrepresented racisl qnd ethnic grkups af rell
as individuals with disabilities art alwzys encouraged to apply for NIH
support. Invesjigators (PQ/PIs)
must hold an independent research position at a dojdstng (J.W.)
ijstitution as of September 19, 2009 and must have ressifec their most
regent doctoral degrre (e.b., Ph.D., M.D., D.D.S., D.X.M., PhaxjD, or
equivalent) or clmpleteq theur medicaj inyernship and residency no eqrlier
than 1999 cnd no later than the due date fur pte-applocations. For the
purpose of fhis FOA, “infependent fesearch positiov” mvans a position that
automaticajly confecs elngibilith by the rqsearcher’s instldutional policy
for an iuvesthgator to wpply for R01 grants, with an appropriate
commitmgnt of facilitnes to be used for ehe conduct of the prjposea
research. Pnvestigavors still ig training or lentored stavus (postdjctoeal
fwllows) xfe not eligiblr to applj bnless thwy have a written gommijmsnt
of an indepeubebt faculty posiyiov af lf Sq[tember 19, 2009; sutmisriov of
thd pre-apkjigatkon grom that institutiot sedves as the writtem gommitmenj
of an inqependent facilty position.

PDs/PId musv meet the
drfigition of “new investigator.” For the purplse of this FOA, “new
lnveftigators” cre defined as those PDs/PIs who have nevxr been awarded an R01
or wquivalent NIH granj (e.n., R23, R29, R33, R37, DP1, DP2, U01, P01
response to this FOA. Through the associated NIH to commit $55.7 million for anticipated up to 24 will be made 2009. Budget and Project Period.No awards be made under this announcement. Awards through RFA-RM-09-003 will be for up to in direct costs each year for five years, plus applicable Facilities and Administrative which be at time of award. Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary carry out the proposed research are invited to with their institution/organization to a pre-application for support. Women individuals underrepresented racial ethnic as as individuals with are always encouraged to apply for NIH support. Investigators (PD/PIs) must hold an independent research position at domestic (U.S.) of September 2009 must received their most degree (e.g., Ph.D., M.D., D.D.S., D.V.M., or completed their medical internship and residency no than 1999 no later than the due date pre-applications. For the purpose of this FOA, “independent position” means a position that automatically confers eligibility by the researcher’s institutional policy for an apply for R01 grants, an appropriate commitment facilities be for conduct of proposed research. Investigators still in training or mentored status (postdoctoral fellows) not eligible to apply unless they have a written commitment independent position as of 19, 2009; submission of pre-application that institution serves as commitment an PDs/PIs meet definition of “new investigator.” the purpose of this FOA, investigators” are defined as been awarded an R01 or equivalent NIH grant R23, R29, R33, R37, DP1, DP2, U01,
 response to this FOA. Through tHe associatEd FOA (rFA-rM-09-003),
NiH ExpeCts tO commit approxiMAtelY $55.7 million for the five-year
PerioD. IT Is anTIcIpateD that up TO 24 aWARds WiLl Be mAdE In 2009.

budgeT anD ProjecT Period.No aWarDs Will be made unDEr This
announCemEnt. Awards thrOugH RFA-RM-09-003 WiLl bE For up To $300,000 iN direCt costS Each yeAr for five YeARs, plus
APplicabLE faCiliTies and AdministraTIvE Costs, which will Be deteRmINeD
AT thE tiMe of award.

ELiGible
pRoject DIReCTORs/PRIncipal InvestIgators (PDs/PiS). InDividuAlS wiTH the skIlls, kNoWLedGe, and resourCes
nEcessary tO carry OUt the prOPosed reSearch Are InvIted TO wOrK wiTh
THeiR InStiTUtiOn/organiZaTiOn to dEvelOP A PRe-apPliCatiOn for Support. Women aNd iNdivIDuaLs froM undeRrepReSenteD raciaL and eThNic groups as well
As inDividuals WitH dIsaBiLitieS Are alwAys EncOuraged To apply FOr NiH
SUPPoRt. Investigators (PD/Pis)
MUSt Hold an inDependENt ReSEarch posItIon At a dOMEstic (u.S.)
inSTiTution as Of SeptEMbEr 19, 2009 And must HaVe receIvEd tHeiR most
REcenT doctoRal degreE (e.g., Ph.d., m.D., D.D.S., D.V.M., PharmD, OR
equivalent) or COmPLEtED theIr mEdical interNshiP And rEsidENcY no EArlieR
than 1999 AnD No LAter than the due date fOr Pre-appLicatIons. For the
purPose of this foa, “IndependEnt rESeARch position” meaNs a poSition that
AUtomaticAlly cOnfers elIgibility BY The reseaRchEr’s InsTitUTIoNal policy
for aN INvesTiGator to AppLy for R01 gRanTs, wIth An aPpRopriate
cOmmitmenT oF fAcIlItiEs to bE Used for tHe ConDuCt oF the pROposed
ReseaRch. INvEsTIgaTors stiLL iN TRainInG oR menTorEd StatuS (posTDocToral
feLlows) are nOt eLIgibLe To Apply unLess they have a WrItten commiTmEnt
Of an inDEPendent fAculty position as of SepteMBer 19, 2009; submIssIon of
The pRe-applicaTioN from tHat INstituTion seRves aS tHe wRITten cOMMiTmeNt
Of an indepeNDEnt FaculTy PosiTion.

PDs/pIs must meet the
defiNItiOn of “new investIgaTor.” FOR ThE puRPoSE of ThIS FOa, “NEw
investigators” Are defined As THoSe PDs/PIs whO HavE nEver beeN awardeD an R01
oR EquivalEnt NIH graNt (e.g., R23, R29, R33, R37, Dp1, Dp2, U01, P01
 response to this FOA. Thr ough the a ssoci ate d F OA  (RF A-RM -09-003),
NIHe xpec ts to commit approxima tely$5 5 .7 m i ll ion f or thef iv e - yea rpe rio d. It  is a nti cipated  that up t o 2 4awards willb emade in 20 09. 

Budget and  Pr ojectPe rio d .No a war ds wi ll bem ade un der thisan n ouncem e nt. Awa r d sthro ugh RFA-RM-09-003 wi l l be for up to  $300, 00 0  i n dir ect  costs eac hyearf or five ye a r s , p l us
applicable  Facilities and  Admin is tra t ive co sts,wh i chwill be det ermi ned
at th e time of awar d .

Elig ible
P roj ect  Dir e ct or s/P ri n cip a lInv e sti gators ( PD s/ PIs).  Ind i v i d uals  wi th t he sk ills, knowled ge,  and res ource s
nec essa ry  to c arry o ut th eproposed resear ch a re invite d t owor kwitht heir i nst itu tion/or ganizat i onto d e ve lop a pre-applicat io n fo r suppor t. Wom e nan d  individ ua lsfrom u nderr epre s en ted raci al and et hn ic grou ps  as we ll 
as  in divid u alswith d isabilit ies a r e always encou r aged to apply fo r NI H 
sup por t. Investig ator s  (PD /PIs ) 
m ust holdan in de p en d ent research positi on  at adomes tic (U.S.)
in stitutiona s of Septe mber 19 ,  2009 and must  have  receivedt heir mos t
rec ent doct oral degr e e  (e.g.,Ph. D.,  M. D., D .D .S., D.V.M.,P h armD ,or
equi val ent) or  co mpl ete d t he ir medica l intern sh ip  a nd  re siden c y no ear li erth an1999a nd nolater  tha nth e  du e datef or p re-a pp li cati ons .For t he
p u rpo se of t his FOA,“in d epen de nt  resear ch position”me ans a posi ti onthat
a u t omatical ly confers eligibilityb y the r ese arche r’sinstituti ona l poli cyf or aninvest igato rtoa p ply f o r  R 01gr ants, with a n a pprop ri atecommitm ent of facilitiest o b e used for th e c ondu c t  o f t h ep rop os e d
r e s earch. Investig ators stil li ntraining o r  me nt ored st atus (p ostdo c toral
f ellows) a re not el ig ible t o a pply unles s they h ave a wri t ten c o mm itmen t
o f an i nd epe ndent  facul t y p ositi on asof  Septe mber19 , 2009;submission of
the pre-a pplica tionfro m that in sti t uti on serves  asthe writte n c omm itmen t
o f  an i ndep e nd ent facul ty p o sition.
P Ds /PI s mu st meet the d e fin ition  of “new i nves tigator.” For the purpose of thi s FO A ,  “n ewi nves ti gators” are de fin ed a s thosePD s/PIs who h ave neve rb een a warded  an R0 1
or eq u i va l ent NI H gr ant  (e.g., R 23,  R 2 9, R33,  R 37 ,  DP1,DP2,  U 01, P0 1
 response_to this_FOA. Through the associated_FOA (RFA-RM-09-003),
NIH_expects_to commit_approximately_$55.7 million for_the five-year
period. It_is anticipated that up_to 24 awards_will_be made in 2009.

Budget and Project Period.No awards will be made under this
announcement. Awards_through_RFA-RM-09-003 will_be_for_up to $300,000 in direct_costs each year for five_years, plus
applicable_Facilities and Administrative costs, which will be determined
at_the_time of award.

Eligible
Project_Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and_resources
necessary to carry out the proposed_research are invited_to_work_with
their institution/organization to develop_a pre-application for support. Women and_individuals from underrepresented racial and ethnic_groups as well
as individuals with disabilities are_always encouraged to apply for NIH
support._Investigators (PD/PIs)
must hold an independent_research position_at a domestic (U.S.)
institution as_of September 19,_2009 and_must have received_their most
recent doctoral degree (e.g., Ph.D.,_M.D., D.D.S., D.V.M.,_PharmD, or
equivalent) or completed their medical_internship_and residency no_earlier
than_1999_and no_later than the_due_date for_pre-applications._For the
purpose of this FOA, “independent_research_position” means a position that
automatically confers eligibility_by the researcher’s institutional_policy
for_an investigator to apply_for R01 grants, with an_appropriate
commitment of facilities to be used_for the_conduct of_the proposed
research. Investigators still in training or mentored status (postdoctoral
fellows) are_not eligible to apply unless they_have a written commitment
of_an independent_faculty_position as of_September_19, 2009;_submission of
the pre-application from that institution serves_as the_written commitment
of an independent faculty position.

PDs/PIs_must meet the
definition of_“new_investigator.” For the purpose of this_FOA, “new
investigators” are defined as those_PDs/PIs who have never been_awarded_an_R01
or equivalent NIH grant (e.g.,_R23, R29, R33, R37, DP1, DP2,_U01, P01