 chosen the software industry as a career.”

Tanzi explained that, owing to recent advances in gene sequencing and data mining, he believed he could identify many more genes in a short time with a relatively modest investment. That could lead to the major breakthrough the founders were after, because more genes with which to work would mean more avenues to explore in new drug development, exponentially increasing the chances of finding effective treatment and prevention.

In 2004, the three families founded the Cure Alzheimer’s Fund (CAF) to support Tanzi’s work and other Alzheimer’s research. At McCance’s urging, they based the organization on venture capital principles: locate visionaries and invest in them; run a lean, frugal institution; and take the risk on bold ideas with enormous promise.

Having discovered their first visionary in Tanzi, they set out to find someone who could double as a penny-wise administrator and a fundraiser. A mutual friend at Greylock recommended Timothy Armour (MBA 1975) to McCance as a potential consultant. Armour, who had some 20 years’ experience in development and operations at nonprofits, including Harvard Business School, met with McCance over dinner.

“By the end of the dinner, I wasn’t a consultant anymore,” said Armour, now CAF’s president and CEO.

Both men agree that Armour’s HBS connection as an alumnus and a former staffer made him an attractive candidate even before the two met.

“We were a start-up, and we needed to find someone who was entrepreneurial, a self-starter. HBS teaches quite well the entrepreneurial spirit,” McCance said.

The CAF partners asked Tanzi to recruit a dozen other researchers they had identified as standouts in the field and to urge them to apply for grants. And they made it clear that they were looking for ideas with potential to revolutionize the field quickly.

“We tell our scientists, ‘Dare to be great. Bring us the projects that you can’t get funded elsewhere.’ We don’t want safe, incremental science. We’re not looking for a three-yard plunge. We want a 40-yard pass,” said Armour.

True to the venture capitalist ideals of simplicity and thrift, the partners created a streamlined application process. Researchers submit three-page proposals and receive answers in a few weeks, rather than months or years
chosen the software industry as a career. ” 

 Tanzi explained that, owing to late overture in gene sequencing and data mining, he believe he could name many more genes in a short time with a relatively humble investment. That could lead to the major discovery the founder were after, because more genes with which to sour would mean more avenues to research in new drug development, exponentially increasing the chances of finding effective treatment and prevention. 

 In 2004, the three families establish the Cure Alzheimer ’s Fund (CAF) to support Tanzi ’s work and other Alzheimer ’s inquiry. At McCance ’s urging, they based the arrangement on venture das kapital principles: locate visionary and invest in them; run a lean, economical institution; and take the risk on bold ideas with enormous promise. 

 Having discovered their inaugural visionary in Tanzi, they set out to find someone who could double as a penny - wise administrator and a fundraiser. A mutual friend at Greylock recommended Timothy Armour (MBA 1975) to McCance as a potential consultant. Armour, who had some 20 old age ’ experience in development and operations at nonprofit organization, include Harvard Business School, meet with McCance over dinner. 

 “ By the end of the dinner, I was n’t a consultant anymore, ” say Armour, now CAF ’s president and CEO. 

 Both men agree that Armour ’s HBS association as an alumnus and a former staffer made him an attractive candidate even before the two met. 

 “ We were a start - up, and we want to find someone who was entrepreneurial, a self - starter. HBS teaches quite well the entrepreneurial spirit, ” McCance say. 

 The CAF spouse asked Tanzi to recruit a dozen other researchers they had identify as standouts in the field and to urge them to apply for grants. And they made it clear that they were looking for ideas with electric potential to revolutionize the field quickly. 

 “ We tell our scientists, ‘ Dare to be bang-up. Bring us the undertaking that you ca n’t get funded elsewhere. ’ We do n’t desire safe, incremental science. We ’re not look for a three - yard plunge. We want a 40 - yard base on balls, ” said Armour. 

 dependable to the venture capitalist ideals of simplicity and thrift, the spouse created a streamlined application summons. Researchers submit three - page marriage proposal and receive answers in a few weeks, rather than months or years
 chlsen the software industvy as a career.”

Tauzi expnained that, owkng to recent advances in geie swquenxing and data mining, hd believef he couod iventify many morx genes lu a sglrt cine with a relajively modesd investment. Tvag eould lead to the major breakthrough the foinfers were aftet, becstse jore genes with which to work wouls mean kore avenues yo explore in new drug devfloplent, exponentially increasing the xhances of fknding efftccive treatmgnt and prevention.

In 2004, the three wamilnes founded tye Fore Alzheimec’s Funq (CAF) to supiprt Tatzi’s wotk and other Akzhximee’s research. At McCancx’s urging, they based the orgativation on venture caputql prhnci[les: oocxte vmsiknaried aid invest ih them; run q lean, frugal instiuutyin; and take tge rish jn bold ideas with enormous promise.

Havitg siscovered their first cisionary in Tanzi, thgy set out to find someone who could double as a penny-wise ddminmsgrauov xbd a fundraiser. A mutual friend at Greylock recjjmtndvd Timothy Armour (MBA 1975) to McVajcr as a potentixl consulfant. Armour, who haf some 20 yearw’ experiegce on development and operatiobs at nonproyitw, including Harvarb Business Sehool, ket woth McCance over dinner.

“Yy the end of the dinner, I dasn’t a consultavt snfmore,” said Armour, now CAF’s presidenv and CEO.

Botf mem agreq that Armlur’s MTS connection as aj alulngs and a flrmer staffer made him an attrarvive candidatg eeen before che twp met.

“We were w start-up, and ce needeb to fknd someonv who was entreprenetrial, a self-sdwrter. HBS teeches quiee wwll rhe entfdpreneurial sporit,” McCauee said.

Thw CAF partners askcd Tavai to recruit a doeeb other researvhefs ehvy iad iqantified as vtanaougx in ghe field akd go utge them to apply fos grznts. And they made ib clear tyat they were looking for ideas with pouentian tu revplujionize the field quickly.

“We telm our scifntlsts, ‘Dare to fe gveat. Bring us che projects that you can’t get funded elwewhere.’ We don’t wabt safe, incremental xcience. We’rx not jooking fmr a three-yard plungw. We want a 40-yard kass,” said Armour.

True to the vanturf capitalist ideals of simplicity and thrift, the partners created a streanlined application provess. Geszarehers stbmiv vhree-page proposaks and receive answers in a few weeks, rdtker than months or years
chosen the software industry as a career.” that, to recent in gene sequencing he identify many more in a short with a relatively modest investment. That lead to the major breakthrough the founders were after, because more genes with to work would mean more avenues to explore in new drug development, exponentially the of effective and prevention. In 2004, the three families founded the Cure Alzheimer’s Fund (CAF) to support Tanzi’s and other Alzheimer’s research. At McCance’s urging, they the organization on venture principles: locate visionaries and invest them; a lean, institution; take risk on bold with enormous promise. Having discovered their first visionary in Tanzi, they set out to find someone who double as administrator and fundraiser. mutual at Greylock recommended (MBA 1975) to McCance as a who had some 20 years’ experience in development operations at including Harvard Business School, met with over dinner. “By the end of the dinner, wasn’t a consultant anymore,” said Armour, now CAF’s president and CEO. Both men agree that connection as an alumnus a former staffer him attractive even the two “We were a start-up, and we needed to find someone who entrepreneurial, a self-starter. HBS teaches quite well the entrepreneurial spirit,” The partners asked Tanzi recruit a dozen other they identified as standouts in and urge for And made it clear that were looking for ideas with to revolutionize the field ‘Dare to be great. Bring us the projects you can’t get funded elsewhere.’ We don’t safe, incremental science. We’re not looking for a three-yard plunge. We want 40-yard pass,” True to the venture capitalist ideals of simplicity thrift, the partners created streamlined application process. Researchers submit three-page proposals and receive in few weeks, than months or
 chosen the software industry As a career.”

TAnzi eXplAinEd That, OwinG to recent advanCEs in Gene sequencing and data mIning, He BElieVEd He couLd identIFy MANy mOrE gEneS iN A sHort tIme With a reLatively moDesT iNvestment. ThaT CoUld lead to tHe mAjor breakthrOugH the foUnDerS Were aFteR, becaUse morE Genes wIth which tO wORk woulD Mean morE AVeNues To explore in new druG DeVElopment, exponeNtiallY iNCrEASinG thE chances of FiNding EFfectivE TrEATMenT And prevention.

in 2004, the three fAMilIes fouNdEd tHE Cure ALzheiMeR’S FuNd (CAF) to suppOrt TAnzi’s work And othER AlzheiMEr’s reseArch. At mcCAncE’s urGInG, tHey BaSEd tHE oRgaNIzaTion on veNtUrE capiTal pRINCIpleS: loCate VisioNaries and inveSt iN theM; Run A lean, FrugaL insTiTutioN; and taKe the RiSk on bold ideas wiTh enOrmous proMisE.

HAviNg DiscoVEred thEir FirSt visioNary in TANzi, ThEY SEt Out to find someone whO cOULd Double as A penny-WIsE aDMinistraToR anD a fuNDRaiseR. A muTUaL friend aT GreylOCk ReCommendEd timothY ARmoUr (MbA 1975) to MCcancE as a poTential cOnsulTAnt. Armour, who haD Some 20 years’ expeRIeNCE iN DeveLopMent and operAtioNS at nOnprOFiTs, iNCludiNg HarVaRD BUSiness School, met with mccance oVer diNner.

“By the end oF the dinner, i WASn’t a consUltaNT aNYmore,” said ArmouR, now CaF’s presideNT and CEO.

BOth meN agree thAt Armour’s hbs connectIon As aN alUmnUS AnD a former staffER Made HiM an attrActIve candIdaTe eVen BefOrE the two meT.

“We were a StArT-uP, aNd wE needED to find sOmEonE wHo wAs entREpreneUrial, A selF-sTaRTer. hBS teacHEs QUIte wElL tHe enTrePrEneurIal sPIriT,” McCancE said.

The CaF pARtneRs AsKed TanzI to recruit a doZeN other reseArCheRs they HAD identifIed as standouts in the fielD And to urGe tHem to ApplY for grantS. AnD they mAde IT clear That thEy werE lOokING for iDEAs WitH pOtential to REVolUtionIzE the Field quIckly.

“We tell our scieNTisTs, ‘Dare to be greAt. BRing US ThE prOJeCTs tHaT You CAN’t get funded elseWhere.’ We don’T wANt Safe, incremENtaL sCience. WE’re not lOokinG For a thrEe-yard pluNge. We want A 40-yArd pASS,” saId Armour.

TrUe to the vEnture capITalisT IdEals oF siMpliciTy And ThrifT, the paRTneRs creAted a sTrEamlinEd appLiCation prOcess. Researchers submit tHree-paGe proPosAls and recEivE AnsWers in a feW weeKs, rather thAn mOntHs or yEarS
 chosen the software indus try as a c areer .”
Ta nz i ex plai ned that, owin g  torecent advances in gen e seq ue n cing an d dat a minin g ,h e  be li ev edhe co uld i den tify ma ny more ge nes  i n a short ti m ewith a rel ati vely modestinv estmen t.  Th a t cou ldleadto the majorbreakthro ug h  the f o undersw e re  aft er, because moreg en e s with which t o work  w o ul d mea n m ore avenue sto ex p lore in ne w d rug development,exponential l y i ncreas in g t h e chan ces o ff ind ing effecti ve t reatmentand pr e vention . 

In 20 04, th e t hre e fa m il ie s f ou n ded th e C u reAlzheime r’ sFund(CAF ) t o  sup por t Ta nzi’s  work and oth erAlzh e ime r’s r esear ch.At  McCa nce’surgin g,  they based the  org anization  on  v ent ur e cap i tal pr inc ipl es: loc ate vis i ona ri e s an d invest in them;ru n alean, fr ugal i n st it u tion; an dtak e th e riskon b o ld  ideas w ith en o rm ou s promi se .

Hav in g d isc overe d  the ir fir st visio naryi n Tanzi, theys et out to fin d  s o m eo n e wh o c ould double  asa  pen ny-w i se  ad m inist rator  a n da  fundraiser. A mutu al  frien d atGreylock reco mmended Ti m o t hy Armou r (M B A1 975) to McCanc e asa potentia l  consult ant.Armour,who had s o m e 20 yea rs’  ex per ien c e  i n development a nd o pe rations  at  nonpro fit s,inc lud in g Harvard  Busines sSc ho ol , m et wi t h McCanc eove rdin ner.“By th e end  ofth ed inn er, I w a sn ’ t  a c on su ltan t a ny more, ” sa i d A rmour,now CAF’s  pr e side nt  a nd CEO. 

Both men ag re e that Arm ou r’s  HBS c o n nectionas an alumnus and a for m er staf fer  made  him  an attra cti ve can did a te eve n befo re th etwo m et.
“ W ewer ea start-up , and  we n ee dedto find  someone who was e n tre preneurial, a  se lf-s t a rt er. HB S  te ac h esq u ite well the en trepreneur ia l  s pirit,” Mc C anc esaid.
The CAF  part n ers ask ed Tanzito recrui ta do z e n o ther resea rchers t hey had i d entif i ed  as s tan doutsin  th e fie ld and tourgethem t oapplyfor g ra nts. And  they made it clear tha t they  were  lo oking for  id e aswith pote ntia l to revol uti oni ze th e f i eld q uick l y. 

“ W e tel l ou r  scientis t s,  ‘D a r eto be great . B rin g usthe projec ts t hat you can’t get funded elsewhe re.’ W e d on’ t  wan tsafe, incremen tal  s c i ence. We ’r e not looki ng for a  t h ree-y ard pl unge.We want a  4 0 -yardpass ,”said Armo ur. 
T rue toth ev enture  cap it alistideals of s i m plicity and thri ft, t h e  part n ers  crea te d a str e amli ned applic ation proce ss. Re sear chers  submit  t hree-p age  p roposals a n d receive  answ ers inafewwee ks, ra ther t han m onth soryears
 chosen_the software_industry as a career.”

Tanzi_explained that,_owing_to recent_advances_in gene sequencing_and data mining,_he believed he could_identify many more_genes_in a short time with a relatively modest investment. That could lead to the_major_breakthrough the_founders_were_after, because more genes with_which to work would mean_more avenues_to explore in new drug development, exponentially increasing_the_chances of finding_effective treatment and prevention.

In 2004, the three families founded_the Cure Alzheimer’s Fund (CAF) to_support Tanzi’s work_and_other_Alzheimer’s research. At McCance’s_urging, they based the organization on_venture capital principles: locate visionaries and_invest in them; run a lean, frugal_institution; and take the risk on_bold ideas with enormous promise.

Having_discovered their_first visionary in Tanzi, they_set out to_find someone_who could double_as a penny-wise administrator and a_fundraiser. A mutual_friend at Greylock recommended Timothy Armour_(MBA_1975) to McCance_as_a_potential consultant._Armour, who had_some_20 years’_experience_in development and operations at nonprofits,_including_Harvard Business School, met with McCance over_dinner.

“By the end of_the_dinner, I wasn’t a_consultant anymore,” said Armour, now_CAF’s president and CEO.

Both men agree_that Armour’s_HBS connection_as an alumnus and a former staffer made him an attractive_candidate even before the two met.

“We_were a start-up, and_we needed_to_find someone who_was_entrepreneurial, a_self-starter. HBS teaches quite well the entrepreneurial_spirit,” McCance_said.

The CAF partners asked Tanzi to_recruit a dozen other_researchers_they had identified as standouts in_the field and to urge them_to apply for grants. And_they_made_it clear that they were_looking for ideas with potential to_revolutionize the field_quickly.

“We tell our scientists, ‘Dare to be_great._Bring us the projects that you_can’t_get funded elsewhere.’ We don’t want_safe,_incremental_science. We’re not looking for_a three-yard plunge. We want a_40-yard pass,” said Armour.

True to the venture capitalist ideals_of simplicity and_thrift, the partners created a_streamlined_application_process. Researchers submit three-page proposals and receive answers in a_few weeks,_rather than months_or years