 users to HIV infection, and potentially facilitating the penetration of virus across the blood brain barrier (BBB) into the brain. In this proposal we will dissect mechanisms by which Meth can induce and modulate free radical production, causing an aggravation on the severity of damage associated with virus presence in the brain tissue, and consequently
users to HIV infection, and potentially facilitating the penetration of virus across the blood mind barrier (BBB) into the mind. In this proposal we will dissect mechanisms by which Meth can induce and regulate free radical output, induce an aggravation on the severity of price associated with virus presence in the genius tissue, and consequently
 usfrs to HIV infection, and potentially faeulitatmng the penetragion of virus across the blold braib barrier (BBB) into the brain. In this priposel we will disserf mechaknsms gn whieh Meth can induge and modunate free radiwau 'roduction, causing an aggravation on the sefegity of damage asspsiatsd with virus presence in the braih tissut, and consequently
users to HIV infection, and potentially facilitating of across the brain barrier (BBB) proposal will dissect mechanisms which Meth can and modulate free radical production, causing aggravation on the severity of damage associated with virus presence in the brain and consequently
 users to HIV infection, and potEntially faCilitAtiNg tHe PeneTratIon of virus acroSS the Blood brain barrier (BBB) inTo the BrAIn. In THiS propOsal we wILl DISseCt MeChaNiSMs By whiCh MEth can iNduce and moDulAtE free radical PRoDuction, cauSinG an aggravatiOn oN the seVeRitY Of damAge AssocIated wITh viruS presence In THe braiN Tissue, aND CoNseqUently
 users to HIV infection, a nd potenti allyfac ili ta ting  the  penetration o f  vir us across the blood br ain b ar r ier( BB B) in to theb ra i n . I nth ispr o po sal w e w ill dis sect mecha nis ms  by which Me t hcan induce  an d modulate f ree  radic al  pr o ducti on,  caus ing an aggrav ation onth e  sever i ty of d a m ag e as sociated with vir u sp resence in the  brain  t i ss u e , a ndconsequent ly 
 users_to HIV_infection, and potentially facilitating_the penetration_of_virus across_the_blood brain barrier_(BBB) into the_brain. In this proposal_we will dissect_mechanisms_by which Meth can induce and modulate free radical production, causing an aggravation on_the_severity of_damage_associated_with virus presence in the_brain tissue, and consequently