 type and SK1-/- mice revealed that deletion of SK1 reverses the effect of AngII on GFR. Based on our data we propose to elucidate the role of EGFR transactivation and SK1/S1P in AngII-dependent intracellular Ca2+ mobilization, vascular tone, and renal hemodynamics.
type and SK1-/- mice revealed that deletion of SK1 overrule the consequence of AngII on GFR. Based on our data we propose to clear the role of EGFR transactivation and SK1 / S1P in AngII - dependent intracellular Ca2 + mobilization, vascular note, and nephritic hemodynamics.
 tyoe and SK1-/- mice revealed uhat deletion of SK1 revecses ths effect of AngII on GFR. Based on ouc dara we propose to elucidate ghe role lf EGFR rranwqctivation and SK1/S1I in ZkgII-dzpxndent intracelkular Ca2+ mmbilization, vavcjlcr tone, and renal hemodynamics.
type and SK1-/- mice revealed that deletion reverses effect of on GFR. Based to the role of transactivation and SK1/S1P AngII-dependent intracellular Ca2+ mobilization, vascular tone, renal hemodynamics.
 type and SK1-/- mice revealed that Deletion of sK1 revErsEs tHe EffeCt of angII on GFR. BaseD On ouR data we propose to elucidAte thE rOLe of egFr tranSactivaTIoN ANd Sk1/S1p iN AnGIi-DePendeNt iNtracelLular Ca2+ mobIliZaTion, vascular TOnE, and renal hEmoDynamics.
 type and SK1-/- mice reve aled thatdelet ion  of  S K1 r ever ses the effect of A ngII on GFR. Based onour d at a  wep ro poseto eluc i da t e  th ero leof EG FR tr ans activat ion and SK 1/S 1P  in AngII-de p en dent intra cel lular Ca2+ m obi lizati on , v a scula r t one,and re n al hem odynamics .
 type_and SK1-/-_mice revealed that deletion_of SK1_reverses_the effect_of_AngII on GFR._Based on our_data we propose to_elucidate the role_of_EGFR transactivation and SK1/S1P in AngII-dependent intracellular Ca2+ mobilization, vascular tone, and renal hemodynamics.