 has currently identified associations between clubfoot and variation in HoxA, HoxD, IGFBP3 and apoptotic pathway genes. In addition, three functional polymorphisms in NAT2 will be evaluated to look for an interaction with maternal smoking and the risk of clubfoot. Saliva samples will be available on over 400 clubfoot
has currently identified associations between clubfoot and variation in HoxA, HoxD, IGFBP3 and apoptotic nerve pathway gene. In summation, three functional polymorphism in NAT2 will be evaluate to look for an interaction with maternal smoke and the hazard of clubfoot. Saliva samples will be available on over 400 clubfoot
 had currently identified arsociations betcwen clnbfoot znd varixtion in HoxA, HoxD, IGFBP3 and apoptoupc pathway genes. In aadition, tjree funxtioial polymorphisms in NAT2 will gc evannated to look fpr an intesaction with mdtdrual smoking and the risk of clubfoot. Saliva swmples will be avaplwble on over 400 clubfoot
has currently identified associations between clubfoot and HoxA, IGFBP3 and pathway genes. In NAT2 be evaluated to for an interaction maternal smoking and the risk of Saliva samples will be available on over 400 clubfoot
 has currently identified assOciations bEtweeN clUbfOoT and VariAtion in HoxA, Hoxd, iGFBp3 and apoptotic pathway geNes. In AdDItioN, ThRee fuNctionaL PoLYMorPhIsMs iN Nat2 wIll be EvaLuated tO look for an IntErAction with maTErNal smoking And The risk of cluBfoOt. SaliVa SamPLes wiLl bE avaiLable oN Over 400 clUbfoot
 has currently identifiedassociatio ns be twe encl ubfo ot a nd variation i n  Hox A, HoxD, IGFBP3 and ap optot ic path w ay  gene s. In a d di t i on,  t hr eefu n ct ional  po lymorph isms in NA T2wi ll be evalua t ed  to look f oran interacti onwith m at ern a l smo kin g and  the r i sk ofclubfoot.  S a liva s a mples w i l lbe a vailable on over4 00 clubfoot
 has_currently identified_associations between clubfoot and_variation in_HoxA,_HoxD, IGFBP3_and_apoptotic pathway genes._In addition, three_functional polymorphisms in NAT2_will be evaluated_to_look for an interaction with maternal smoking and the risk of clubfoot. Saliva samples_will_be available_on_over_400 clubfoot