 we hypothesized that combinations of: a) intestinal stem cell growth factor, R-spondinl (R-spol), b) TLR ligands, and c) transplantation of bone marrow-derived endothelial progenitor cells (EPC) and mesenchymal stem cells (MSC) would restore the IR-damaged ISC niche
we hypothesized that combinations of: a) intestinal stem cell increase agent, R - spondinl (R - spol), b) TLR ligands, and c) transplant of bone marrow - derived endothelial progenitor cell (EPC) and mesenchymal bow cells (MSC) would regenerate the IR - damaged ISC niche
 we hypothesized that combikations of: a) intgsrinal vtem csll growgh factor, R-spondinl (R-spol), b) VLR oiganes, and c) transplantatiun of bonv marrow-dwrivtd endothelial progenitor cells (CPC) aud mesenchymal sjem cells (MSW) would restora ghz IR-damaged ISC niche
we hypothesized that combinations of: a) intestinal growth R-spondinl (R-spol), TLR ligands, and endothelial cells (EPC) and stem cells (MSC) restore the IR-damaged ISC niche
 we hypothesized that combinaTions of: a) inTestiNal SteM cEll gRowtH factor, R-spondiNL (R-spOl), b) TLR ligands, and c) transPlantAtIOn of BOnE marrOw-derivED eNDOthElIaL prOgENiTor ceLls (ePC) and mEsenchymal SteM cElls (MSC) would REsTore the IR-dAmaGed ISC niche
 we hypothesized that comb inations o f: a)  in tes ti nalstem  cell growth f a ctor , R-spondinl (R-spol),  b) T LR liga n ds , and  c) tra n sp l a nta ti on  of  b o ne  marr ow- derived  endotheli alpr ogenitor cel l s(EPC) andmes enchymal ste m c ells ( MS C)w ouldres torethe IR - damage d ISC nic he 
 we_hypothesized that_combinations of: a) intestinal_stem cell_growth_factor, R-spondinl_(R-spol),_b) TLR ligands,_and c) transplantation_of bone marrow-derived endothelial_progenitor cells (EPC)_and_mesenchymal stem cells (MSC) would restore the IR-damaged ISC niche