 mice deficient in the production of Ebi3 have accelerated development of atrophy and spasmolytic polypeptide expressing metaplasia (SPEM), important preneoplastic epithelial cell lesions. We have also observed that Tregs, which are critical suppressors of gastritis and resulting lesions, exhibit a defective phenotype in Ebi3-/-
mice deficient in the production of Ebi3 have accelerated growth of atrophy and spasmolytic polypeptide carry metaplasia (SPEM), important preneoplastic epithelial cell lesions. We have besides observed that Tregs, which are critical suppressors of gastritis and resulting lesion, exhibit a defective phenotype in Ebi3-/-
 mife deficient in the prodmction of Ebi3 harw accenerates develooment of atrophy and spasmolbtic polykvptide expressing metxplasia (SIEM), imporrant preneoplasvjc epitmzlial gell nxsions. We have slso obsereed that Tregs, wfieh are critical suppressors of gastrytis anc gesulting lesijns, txhybit a defective phenotype in Ebi3-/-
mice deficient in the production of Ebi3 development atrophy and polypeptide expressing metaplasia lesions. have also observed Tregs, which are suppressors of gastritis and resulting lesions, a defective phenotype in Ebi3-/-
 mice deficient in the productIon of Ebi3 haVe accEleRatEd DeveLopmEnt of atrophy anD SpasMolytic polypeptide exprEssinG mETaplASiA (SPEM), ImportaNT pRENeoPlAsTic EpIThElial CelL lesionS. We have alsO obSeRved that TregS, WhIch are critIcaL suppressors Of gAstritIs And REsultIng LesioNs, exhiBIt a defEctive pheNoTYpe in EBI3-/-
 mice deficient in the pro duction of  Ebi3  ha veac cele rate d developmento f at rophy and spasmolyticpolyp ep t idee xp ressi ng meta p la s i a ( SP EM ),im p or tantpre neoplas tic epithe lia lcell lesions .  W e have als o o bserved that  Tr egs, w hi cha re cr iti cal s uppres s ors of  gastriti sa nd res u lting l e s io ns,exhibit a defecti v ep henotype in Eb i3-/-
 mice_deficient in_the production of Ebi3_have accelerated_development_of atrophy_and_spasmolytic polypeptide expressing_metaplasia (SPEM), important_preneoplastic epithelial cell lesions._We have also_observed_that Tregs, which are critical suppressors of gastritis and resulting lesions, exhibit a defective_phenotype_in Ebi3-/-