 analysis of LDZ spheres at G1-G4 confirmed that a common LDZ signature was characterized by genes associated with oncogenic signaling pathways including tumor initiation, metastasis, and vasculogenesis and was able to predict clinical outcome of liver cancer patients. We conclude that epigenetic reprogramming of liver cancer cell lines induced by a combined
analysis of LDZ spheres at G1 - G4 confirmed that a common LDZ signature was qualify by gene associated with oncogenic signaling pathways include tumor trigger, metastasis, and vasculogenesis and was able to predict clinical outcome of liver cancer affected role. We reason that epigenetic reprogramming of liver cancer cell lines induced by a combined
 anwlysis of LDZ spheres at G1-G4 confirmed tkqt a cmmmon MDZ signxture was characterized by gxnes assoxiated with oncogenic rignaling pathwayw inrluding tumor inmfiation, metasfwsis, end vasculogenexis and wav able to predhcg elinical outcome of liver cancer patyents. Wr fonclude that gpigemqtic gekrogramming of liver cancer cell mines iiduced by a comnined
analysis of LDZ spheres at G1-G4 confirmed common signature was by genes associated tumor metastasis, and vasculogenesis was able to clinical outcome of liver cancer patients. conclude that epigenetic reprogramming of liver cancer cell lines induced by a combined
 analysis of LDZ spheres at G1-G4 cOnfirmed thAt a coMmoN LDz sIgnaTure Was characterizED by gEnes associated with oncoGenic SiGNaliNG pAthwaYs incluDInG TUmoR iNiTiaTiON, mEtastAsiS, and vasCulogenesiS anD wAs able to predICt Clinical ouTcoMe of liver canCer PatienTs. we cONcludE thAt epiGenetiC ReprogRamming of LiVEr cancER cell liNES iNducEd by a combined
 analysis of LDZ spheres a t G1-G4 co nfirm edtha ta co mmon  LDZ signature wascharacterized by genes  asso ci a tedw it h onc ogenics ig n a lin gpa thw ay s  i nclud ing  tumorinitiation , m et astasis, and va sculogenes isand was able  to  predi ct  cl i nical  ou tcome  of li v er can cer patie nt s . We c o ncludet h at  epi genetic reprogram m in g  of liver canc er cel ll in e s  in duc ed by a co mb ined
 analysis_of LDZ_spheres at G1-G4 confirmed_that a_common_LDZ signature_was_characterized by genes_associated with oncogenic_signaling pathways including tumor_initiation, metastasis, and_vasculogenesis_and was able to predict clinical outcome of liver cancer patients. We conclude that_epigenetic_reprogramming of_liver_cancer_cell lines induced by a_combined