 high titer and were genetically stable. They were, however, unable to compete with wild-type virus in mixed infections, suggesting that the location and /or length of the engineered sequence duplication did not provide for preferential packaging of the segment. These results indicate that sequence duplication alone (or increased segment length) is not the
high titer and were genetically stable. They were, however, unable to compete with wild - character virus in assorted infections, suggesting that the placement and /or distance of the engineered sequence duplicate did not provide for preferential packaging of the section. These result indicate that succession duplication alone (or increased segment duration) is not the
 hihh titer and were genetigally stable. Thei qere, hmwever, unable go compete with wild-type virns ib mixtb infections, suggestkng that nhe locatuon end /or length of the englueeres seqbeice duplication did not psovide for prexefeutial packaging of the segment. These resultx lndicate that fequtncq dullication alone (or increased segmeht lenguh) is not the
high titer and were genetically stable. They unable compete with virus in mixed and length of the sequence duplication did provide for preferential packaging of the These results indicate that sequence duplication alone (or increased segment length) is not
 high titer and were geneticalLy stable. ThEy werE, hoWevEr, UnabLe to Compete with wilD-Type Virus in mixed infections, SuggeStINg thAT tHe locAtion anD /Or LENgtH oF tHe eNgINeEred sEquEnce dupLication diD noT pRovide for preFErEntial packAgiNg of the segmeNt. THese reSuLts INdicaTe tHat seQuence DUplicaTion alone (Or INcreasED segmenT LEnGth) iS not the
 high titer and were genet ically sta ble.The y w er e, h owev er, unable toc ompe te with wild-type viru s inmi x ed i n fe ction s, sugg e st i n g t ha tthe  l o ca tionand  /or le ngth of th e e ng ineered sequ e nc e duplicat ion  did not pro vid e forpr efe r entia l p ackag ing of the se gment. Th es e  resul t s indic a t ethat  sequence duplica t io n  alone (or inc reased  s e gm e n t l eng th) is not  t he
 high_titer and_were genetically stable. They_were, however,_unable_to compete_with_wild-type virus in_mixed infections, suggesting_that the location and_/or length of_the_engineered sequence duplication did not provide for preferential packaging of the segment. These results_indicate_that sequence_duplication_alone_(or increased segment length) is_not the