. Specifically, our central hypothesis is that some bacterial and viral components, through TLRs, induce trophoblast apoptosis, leading to adverse pregnancy outcome, such as preterm labor or preeclampsia. In our published studies we found TLR2 activation by gram-positive bacterial peptidoglycan (PDG), and TLR8 activation
. Specifically, our central hypothesis is that some bacterial and viral components, through TLRs, induce trophoblast apoptosis, leading to adverse pregnancy result, such as preterm british labour party or preeclampsia. In our published studies we found TLR2 energizing by gram - positive bacterial peptidoglycan (PDG), and TLR8 activation
. Spfcifically, our central hnpothesis is thaj wome becteriam and vifal components, through TLRs, mnduxe triphoblast apoptosis, lexding to wdverse pregiancy outcome, surg as prccerm mwbor ir preeclampsis. In our pgblished studias wz found TLR2 activation by gram-positide bactrrlal peptidoglysan (KDG), and NLV8 activation
. Specifically, our central hypothesis is that and components, through induce trophoblast apoptosis, such preterm labor or In our published we found TLR2 activation by gram-positive peptidoglycan (PDG), and TLR8 activation
. Specifically, our central hypOthesis is tHat soMe bActErIal aNd viRal components, tHRougH TLRs, induce trophoblast ApoptOsIS, leaDInG to adVerse prEGnANCy oUtCoMe, sUcH As PreteRm lAbor or pReeclampsiA. In OuR published stUDiEs we found TlR2 aCtivation by gRam-PositiVe BacTErial PepTidogLycan (Pdg), and TLr8 activatiOn
. Specifically, our centra l hypothes is is  th atso me b acte rial and viral comp onents, through TLRs,induc et roph o bl ast a poptosi s ,l e adi ng  t o a dv e rs e pre gna ncy out come, such  as  p reterm labor or  preeclamp sia . In our pub lis hed st ud ies we fo und  TLR2  activ a tion b y gram-po si t ive ba c terialp e pt idog lycan (PDG), andT LR 8  activation
. Specifically,_our central_hypothesis is that some_bacterial and_viral_components, through_TLRs,_induce trophoblast apoptosis,_leading to adverse_pregnancy outcome, such as_preterm labor or_preeclampsia._In our published studies we found TLR2 activation by gram-positive bacterial peptidoglycan (PDG), and_TLR8_activation