 of opsonization and phagocytic killing by neutrophils in vitro and in vivo. The key to resolution of pneumococcal carriage appears to be recognition and uptake by macrophages. It remains unclear how the unique population of upper respiratory tract macrophages recognizes colonizing pneumococci. In specific aim#2, we will identify the macrophage receptor
of opsonization and phagocytic killing by neutrophils in vitro and in vivo. The key to resolution of pneumococcal carriage appear to be realization and uptake by macrophages. It remain indecipherable how the unique population of upper respiratory tract macrophage recognizes colonizing pneumococci. In specific aim#2, we will identify the macrophage sense organ
 of opsonization and phagocntic killing by uwutropiils in vitro avd in vivo. The key to resoluvion of pbeumococcal carriage aopears to be recotnitmon and uptake bb macropmcges. Jb remciis unclear how jhe unique pmpulation of u[pdr respiratory tract macrophages recodnizes voponizing pneumjcocbi. In aiegific aim#2, we will identify the mzcrophaje receptor
of opsonization and phagocytic killing by neutrophils and vivo. The to resolution of recognition uptake by macrophages. remains unclear how unique population of upper respiratory tract recognizes colonizing pneumococci. In specific aim#2, we will identify the macrophage receptor
 of opsonization and phagocytIc killing bY neutRopHilS iN vitRo anD in vivo. The key tO ResoLution of pneumococcal caRriagE aPPearS To Be recOgnitioN AnD UPtaKe By MacRoPHaGes. It RemAins uncLear how the UniQuE population oF UpPer respiraTorY tract macropHagEs recoGnIzeS ColonIziNg pneUmococCI. In speCific aim#2, wE wILl idenTIfy the mACRoPhagE receptor
 of opsonization and phago cytic kill ing b y n eut ro phil s in  vitro and inv ivo.  The key to resolution  of p ne u moco c ca l car riage a p pe a r s t obe  re co g ni tionand  uptake  by macrop hag es . It remains un clear howthe  unique popu lat ion of  u ppe r  resp ira torytractm acroph ages reco gn i zes co l onizing p ne umoc occi. In specific ai m #2, we will id entify  t h em a cro pha ge recepto r
 of_opsonization and_phagocytic killing by neutrophils_in vitro_and_in vivo._The_key to resolution_of pneumococcal carriage_appears to be recognition_and uptake by_macrophages._It remains unclear how the unique population of upper respiratory tract macrophages recognizes colonizing_pneumococci._In specific_aim#2,_we_will identify the macrophage receptor