, we propose to investigate in greater detail the effects of guanine nucleotide depletion on DNA synthesis and cell cycle progression. The relative expression of IMPDH I and II during the cell cycle and as a function of cellular proliferation will be examined in normal and neoplastic cell lines. Genomic clones containing the regulatory regions for the two genes
, we propose to investigate in greater detail the effects of guanine nucleotide depletion on deoxyribonucleic acid deduction and cellular telephone cycle progression. The relative formulation of IMPDH I and II during the cell cycle and as a routine of cellular proliferation will be examine in normal and neoplastic cell credit line. Genomic clones containing the regulative regions for the two genes
, we propose to investigate ln greater detail the ehfects kf guanive nucleotide depletion on DIA stnthewis and cell cycle proeression. Nhe relatuve txpression of IMPVG I and II dudlng tke cell cycle anc as a funwtion of cellunaf 'roliferation will be examined in nowmal anc jeoplastic celj limqs. Gsnomic clones containing the regulztory rtgions for the two genes
, we propose to investigate in greater effects guanine nucleotide on DNA synthesis relative of IMPDH I II during the cycle and as a function of proliferation will be examined in normal and neoplastic cell lines. Genomic clones containing regulatory regions for the two genes
, we propose to investigate in gReater detaIl the EffEctS oF guaNine Nucleotide deplETion On DNA synthesis and cell cYcle pRoGRessIOn. the reLative eXPrESSioN oF ImPDh I ANd iI durIng The cell Cycle and as A fuNcTion of cellulAR pRoliferatiOn wIll be examineD in Normal AnD neOPlastIc cEll liNes. GenOMic cloNes contaiNiNG the reGUlatory REGiOns fOr the two genes
, we propose to investigat e in great er de tai l t he  eff ects  of guanine nu c leot ide depletion on DNA s ynthe si s  and ce ll cy cle pro g re s s ion .Th e r el a ti ve ex pre ssion o f IMPDH Iand  I I during the ce ll cycle a ndas a functio n o f cell ul arp rolif era tionwill b e  exami ned in no rm a l andn eoplast i c  c elllines. Genomic cl o ne s  containing th e regu la t or y reg ion s for thetw o gen e s
, we_propose to_investigate in greater detail_the effects_of_guanine nucleotide_depletion_on DNA synthesis_and cell cycle_progression. The relative expression_of IMPDH I_and_II during the cell cycle and as a function of cellular proliferation will be_examined_in normal_and_neoplastic_cell lines. Genomic clones containing_the regulatory regions for the_two genes