 from vessel walls. The consequences of CAA are associated in part with breakdown of the vessel wall. For this reason, we now propose to use novel methods to define the mechanisms that underlie Ali-induced vascular wall injury, including oxidative stress, activation of matrix metalloproteinases and other proteases and injury to vascular smooth muscle
from vessel walls. The consequences of CAA are associated in part with dislocation of the vessel rampart. For this cause, we now nominate to practice novel methods to define the mechanism that underlie Ali - induced vascular wall injury, include oxidative stress, activation of matrix metalloproteinases and early proteases and injury to vascular smooth muscle
 frlm vessel walls. The constquences of CAA ate assocmated ih part wkth breakdown of the vessel xall. For ukis reason, we now prupose to lse novel metiods to define tis mechaknsms fmat uudxrlie Ali-inducec vascular wall injury, itcuubing oxidative stress, activation of iatrix kehalloproteinasgs anc othsg kroteases and injury to vascular amooth kuscle
from vessel walls. The consequences of CAA in with breakdown the vessel wall. propose use novel methods define the mechanisms underlie Ali-induced vascular wall injury, including stress, activation of matrix metalloproteinases and other proteases and injury to vascular smooth
 from vessel walls. The consequEnces of CAA Are asSocIatEd In paRt wiTh breakdown of tHE vesSel wall. For this reason, we Now prOpOSe to USe Novel Methods TO dEFIne ThE mEchAnISmS that UndErlie AlI-induced vaScuLaR wall injury, iNClUding oxidaTivE stress, activAtiOn of maTrIx mETalloProTeinaSes and OTher prOteases anD iNJury to VAscular SMOoTh muScle
 from vessel walls. The co nsequences  of C AAare  a ssoc iate d in part with brea kdown of the vessel wa ll. F or this re ason,  we now pr o p ose  t ouse  n o ve l met hod s to de fine the m ech an isms that un d er lie Ali-in duc ed vascularwal l inju ry , i n cludi ngoxida tive s t ress,activatio no f matr i x metal l o pr otei nases and other p r ot e ases and injur y to v as c ul a r  sm oot h muscle
 from_vessel walls._The consequences of CAA_are associated_in_part with_breakdown_of the vessel_wall. For this_reason, we now propose_to use novel_methods_to define the mechanisms that underlie Ali-induced vascular wall injury, including oxidative stress, activation_of_matrix metalloproteinases_and_other_proteases and injury to vascular_smooth muscle