 activate PTP enzymes by targeting either engineered cysteine residues (Specific Aim 1) or naturally occurring cysteine residues (Specific Aim 2). Specific Aim 1 (Target-specific inhibition and activation of engineered PTPs with biarsenical small molecules) proposes several complementary means for engineering inhibitor- sensitive and activator-sensitive (collectively,
activate PTP enzymes by targeting either engineered cysteine residue (Specific Aim 1) or naturally occur cysteine residues (Specific Aim 2). Specific Aim 1 (Target - specific inhibition and energizing of engineered PTPs with biarsenical small molecules) propose several complementary mean for technology inhibitor- sensitive and activator - sensitive (jointly,
 achivate PTP enzymes by tavgeting either eutineerxd cystsine reskdues (Specific Aim 1) or naturelly occuering cysteine residuer (Specifib Aim 2). Spwcifmc Aim 1 (Target-spxdific ikkibitjln aud activation of engineereg PTPs with bidrreuical small molecules) proposes severwl compkelentary means sor tngyneedpnn inhibitor- sensitive and activafor-sensptive (collectivelu,
activate PTP enzymes by targeting either engineered (Specific 1) or occurring cysteine residues 1 inhibition and activation engineered PTPs with small molecules) proposes several complementary means engineering inhibitor- sensitive and activator-sensitive (collectively,
 activate PTP enzymes by targeTing either EnginEerEd cYsTeinE resIdues (Specific AIM 1) or nAturally occurring cysteIne reSiDUes (SPEcIfic AIm 2). SpeciFIc aIM 1 (TaRgEt-SpeCiFIc InhibItiOn and acTivation of EngInEered PTPs witH BiArsenical sMalL molecules) prOpoSes sevErAl cOMplemEntAry meAns for ENgineeRing inhibItOR- sensiTIve and aCTIvAtor-Sensitive (collectiVElY,
 activate PTP enzymes by t argeting e ither  en gin ee redcyst eine residues( Spec ific Aim 1) or natural ly oc cu r ring cy stein e resid u es ( Spe ci fi c A im 2) . Spe cif ic Aim1 (Target- spe ci fic inhibiti o nand activa tio n of enginee red  PTPswi thb iarse nic al sm all mo l ecules ) propose ss everal complem e n ta ry m eans for engineer i ng inhibitor- sen sitive  a n da c tiv ato r-sensitiv e(coll e ctively , 
 activate_PTP enzymes_by targeting either engineered_cysteine residues_(Specific_Aim 1)_or_naturally occurring cysteine_residues (Specific Aim_2). Specific Aim 1_(Target-specific inhibition and_activation_of engineered PTPs with biarsenical small molecules) proposes several complementary means for engineering inhibitor-_sensitive_and activator-sensitive_(collectively,