) leukocyte engagement of fibrin within challenged tissues is an important cue in "target recognition" leading to the implementation of effective antimicrobial functions, and iv) hemostatic factors control leukocyte activation events as well as macrophage egress from inflammatory sites into lymphatics. These hypotheses will be tested through detailed studies of S. aureus virulence/
) leukocyte engagement of fibrin within challenged tissues is an important clue in " prey recognition " leading to the implementation of effective antimicrobial function, and iv) hemostatic factors master leukocyte energizing events as well as macrophage egress from inflammatory sites into lymphatics. These guess will be tested through detailed studies of S. aureus virulence/
) lekkocyte engagement of finrin within challenged vissues is an ioportant cue in "target recogiitiin" leqding to the implementxtion of vffective antmmicrobial functmkns, and iv) hejlstacir factors contrpl leukocyde activation avdncs as well as macrophage egress from inflamkahory sites intj lyk[hatjbs. These hypotheses will be tesfed thrmugh detailed studies of S. aureus virulfnce/
) leukocyte engagement of fibrin within challenged an cue in recognition" leading to functions, iv) hemostatic factors leukocyte activation events well as macrophage egress from inflammatory into lymphatics. These hypotheses will be tested through detailed studies of S. aureus
) leukocyte engagement of fibrIn within chAllenGed TisSuEs is An imPortant cue in "taRGet rEcognition" leading to the ImpleMeNTatiON oF effeCtive anTImICRobIaL fUncTiONs, And iv) HemOstatic Factors conTroL lEukocyte actiVAtIon events aS weLl as macrophaGe eGress fRoM inFLammaTorY siteS into lYMphatiCs. These hyPoTHeses wILl be tesTED tHrouGh detailed studies OF S. AUreus virulence/
) leukocyte engagement offibrin wit hin c hal len ge d ti ssue s is an import a nt c ue in "target recognit ion"le a ding to  theimpleme n ta t i onof  e ffe ct i ve  anti mic robialfunctions,  an div) hemostat i cfactors co ntr ol leukocyte  ac tivati on  ev e nts a s w ell a s macr o phageegress fr om inflam m atory s i t es  int o lymphatics. The s eh ypotheses will  be te st e dt h rou ghdetailed s tu dieso f S. au r eu s v iru l ence/
) leukocyte_engagement of_fibrin within challenged tissues_is an_important_cue in_"target_recognition" leading to_the implementation of_effective antimicrobial functions, and_iv) hemostatic factors_control_leukocyte activation events as well as macrophage egress from inflammatory sites into lymphatics. These_hypotheses_will be_tested_through_detailed studies of S. aureus_virulence/