 in understanding the immunosuppressive microenvironment within solid tumors. Because of their central role in mediating immunosuppression, tumor associated macrophages (TAMs), typically?polarized? to a so-called M2- like immunosuppressive phenotype, and myeloid-derived suppressor cells (MDSC), are thought to be important therapeutic targets. We have found
in understanding the immunosuppressive microenvironment within solid tumors. Because of their central function in mediating immunosuppression, tumor consociate macrophages (TAMs), typically?polarized? to a so - call M2- like immunosuppressive phenotype, and myeloid - derived suppressor cells (MDSC), are think to be crucial therapeutic targets. We have found
 in understanding the immunusuppressive mieeoenviconment within rolid tumors. Because of theic cebtral role in mediating immjnosuppredsion, tunor essociated macro'gages (TAMs), tyllcallv?pilarized? to a xo-called M2- like immunosu[pfedsive phenotype, and myeloid-derived fuppresxog cells (MDSC), ate thptght no be important therapeutic tarfets. We have found
in understanding the immunosuppressive microenvironment within solid of central role mediating immunosuppression, tumor a M2- like immunosuppressive and myeloid-derived suppressor (MDSC), are thought to be important targets. We have found
 in understanding the immunosUppressive MicroEnvIroNmEnt wIthiN solid tumors. BeCAuse Of their central role in meDiatiNg IMmunOSuPpresSion, tumOR aSSOciAtEd MacRoPHaGes (TAms), tYpicallY?polarized? To a So-Called M2- like iMMuNosuppressIve Phenotype, and MyeLoid-deRiVed SUppreSsoR cellS (MDSC), aRE thougHt to be impOrTAnt theRApeutic TARgEts. WE have found
 in understanding the immu nosuppress ive m icr oen vi ronm entwithin solid t u mors . Because of their cen tralro l e in me diati ng immu n os u p pre ss io n,tu m or  asso cia ted mac rophages ( TAM s) , typically? p ol arized? to  aso-called M2 - l ike im mu nos u ppres siv e phe notype ,  and m yeloid-de ri v ed sup p ressorc e ll s (M DSC), are thought to be important t herape ut i ct a rge ts.  We have f ou nd
 in_understanding the_immunosuppressive microenvironment within solid_tumors. Because_of_their central_role_in mediating immunosuppression,_tumor associated macrophages_(TAMs), typically?polarized? to a_so-called M2- like_immunosuppressive_phenotype, and myeloid-derived suppressor cells (MDSC), are thought to be important therapeutic targets. We_have_found