 smokers take in nicotine by inhalation and as one of over 4,000 chemicals present in cigarette smoke. The adequacy of using such artificial dosing paradigms to model cigarette smoking is unknown and largely untested. We have adapted and characterized methods for inhalation exposure of rats to smoke simulating the smoking of 1 cigarette or periods of
smokers take in nicotine by inhalation and as one of over 4,000 chemicals present in cigarette fastball. The sufficiency of using such artificial dosing paradigms to exemplar cigarette smoke is unknown and largely untested. We have adjust and characterized method acting for inhalation vulnerability of rats to smoke simulate the smoking of 1 cigarette or periods of
 smlkers take in nicotine bn inhalation and as one of ovsr 4,000 chemkcals present in cigarette sloje. Tht adequacy of using such artpficial disinj paradigms to model cigarette dmoknnj is unknown anc largely gntested. We haee abapted and characterized methods for inhalayiln exposure of ratx to amoke simulating the smoking of 1 cjgarettt or periods of
smokers take in nicotine by inhalation and of 4,000 chemicals in cigarette smoke. artificial paradigms to model smoking is unknown largely untested. We have adapted and methods for inhalation exposure of rats to smoke simulating the smoking of 1 or periods of
 smokers take in nicotine by inHalation anD as onE of OveR 4,000 cHemiCals Present in cigarETte sMoke. The adequacy of using Such aRtIFiciAL dOsing ParadigMS tO MOdeL cIgAreTtE SmOking Is uNknown aNd largely uNteStEd. We have adapTEd And charactEriZed methods foR inHalatiOn ExpOSure oF raTs to sMoke siMUlatinG the smokiNg OF 1 cigarETte or peRIOdS of
 smokers take in nicotineby inhalat ion a ndason e of  ove r 4,000 chemic a ls p resent in cigarette sm oke.Th e  ade q ua cy of  usings uc h art if ic ial  d o si ng pa rad igms to  model cig are tt e smoking is un known andlar gely unteste d.We hav eada p ted a ndchara cteriz e d meth ods for i nh a lation exposur e of  rat s to smoke simula t in g  the smoking o f 1 ci ga r et t e  or  pe riods of
 smokers_take in_nicotine by inhalation and_as one_of_over 4,000_chemicals_present in cigarette_smoke. The adequacy_of using such artificial_dosing paradigms to_model_cigarette smoking is unknown and largely untested. We have adapted and characterized methods for_inhalation_exposure of_rats_to_smoke simulating the smoking of_1 cigarette or periods of