 (apo) E in peripheral tissues. The proposal consists of 4 aims that are focused on activities of apoE that influence cellular cholesterol metabolism in adrenal cells and activities that are anti-atherogenic within the vascular wall. Experiments in Aim 1 will test the hypothesis that low levels of systemic apoE act within the vascular wall to
(apo) E in peripheral tissues. The proposal consists of 4 aim that are concenter on activities of apoE that influence cellular cholesterol metabolism in adrenal cell and activities that are anti - atherogenic within the vascular wall. experiment in Aim 1 will test the hypothesis that abject levels of systemic apoE act within the vascular wall to
 (apl) E in peripheral tissuer. The proposal einsistv of 4 zims thag are focused on activities lf apoE that influence cellulxr cholesnerol metqbolmsm in adrenal cxmls and activjbies chet are anti-athetogenic withhn the vasculas dapl. Experiments in Aim 1 will test thq hypotnedis that low lgvels jf sgstemic apoE act within the vasculzr wall to
(apo) E in peripheral tissues. The proposal 4 that are on activities of metabolism adrenal cells and that are anti-atherogenic the vascular wall. Experiments in Aim will test the hypothesis that low levels of systemic apoE act within the wall to
 (apo) E in peripheral tissues. ThE proposal cOnsisTs oF 4 aiMs That Are fOcused on activiTIes oF apoE that influence cellUlar cHoLEsteROl MetabOlism in ADrENAl cElLs And AcTIvIties ThaT are antI-atherogenIc wItHin the vasculAR wAll. ExperimEntS in Aim 1 will teSt tHe hypoThEsiS That lOw lEvels Of systEMic apoe act withiN tHE vascuLAr wall tO
 (apo) E in peripheral tis sues. Thepropo sal  co ns ists  of4 aims that ar e  foc used on activities ofapoEth a t in f lu encecellula r  c h o les te ro l m et a bo lisminadrenal  cells and  ac ti vities thata re  anti-athe rog enic withinthe  vascu la r w a ll. E xpe rimen ts inA im 1 w ill testth e  hypot h esis th a t  l ow l evels of systemic ap o E act within t he vas cu l ar w all  to 
 (apo)_E in_peripheral tissues. The proposal_consists of_4_aims that_are_focused on activities_of apoE that_influence cellular cholesterol metabolism_in adrenal cells_and_activities that are anti-atherogenic within the vascular wall. Experiments in Aim 1 will test_the_hypothesis that_low_levels_of systemic apoE act within_the vascular wall to