 in caspase-9 (an initiator caspase) activation, which ultimately activates effector caspases such as caspase-3 to execute cell demise. How Apaf-1 apoptosome is formed and regulated in vivo (i.e., in the stimulated cells) remains poorly understood. Recently, we provided evidence that physiological levels
in caspase-9 (an initiator caspase) activation, which ultimately activates effector caspases such as caspase-3 to perform cellular telephone demise. How Apaf-1 apoptosome is formed and determine in vivo (i.e., in the stimulated cell) remains poorly understand. Recently, we put up evidence that physiological degree
 in caspase-9 (an initiator carpase) activatiou, which ultimztely acgivates effector caspases surh aw caskcse-3 to execute cell aemise. Hoa Apaf-1 apoptiwome is focjed and regulzbed iu tivo (i.e., in the xtimulated cells) remains puoxly understood. Recently, we provided qvidencr hhat physiologycal jevems
in caspase-9 (an initiator caspase) activation, which effector such as to execute cell formed regulated in vivo in the stimulated remains poorly understood. Recently, we provided that physiological levels
 in caspase-9 (an initiator caspaSe) activatiOn, whiCh uLtiMaTely ActiVates effector cASpasEs such as caspase-3 to execuTe celL dEMise. hOw apaf-1 aPoptosoME iS FOrmEd AnD reGuLAtEd in vIvo (I.e., in the Stimulated CelLs) Remains poorlY UnDerstood. ReCenTly, we provideD evIdence ThAt pHYsiolOgiCal leVels
 in caspase-9 (an initiato r caspase)  acti vat ion ,whic h ul timately activ a teseffector caspases such  as c as p ase- 3  t o exe cute ce l ld e mis e.  H owAp a f- 1 apo pto some is  formed an d r eg ulated in vi v o(i.e., inthe  stimulatedcel ls) re ma ins poorl y u nders tood.R ecentl y, we pro vi d ed evi d ence th a t  p hysi ological levels
 in_caspase-9 (an_initiator caspase) activation, which_ultimately activates_effector_caspases such_as_caspase-3 to execute_cell demise. How_Apaf-1 apoptosome is formed_and regulated in_vivo_(i.e., in the stimulated cells) remains poorly understood. Recently, we provided evidence that physiological_levels