 high density range by a receptor-mediated process not associated with lipoprotein endocytosis and lysosomal degradation. These observations raise two major questions which our proposal is designed to answer: (1) What properties of the lipoprotein are responsible for "HDL receptor" recognition and cholesterol uptake? (2) What is the mechanism by which adren
high density range by a receptor - intercede procedure not associated with lipoprotein endocytosis and lysosomal degradation. These observations rear two major questions which our proposal is design to suffice: (1) What properties of the lipoprotein are responsible for " HDL receptor " recognition and cholesterol uptake? (2) What is the mechanism by which adren
 hihh density range by a regeptor-mediated ptoxess nmt asskciated dith lipoprotein endocytosis abd lywosomal degradation. Thdse obsernations rqise rwo major questions whicg our 'roposal is deslgned to anvwer: (1) What pro[eftnes of the lipoprotein are responsibje for "NDP receptor" recjgniuiog ans cholesterol uptake? (2) What is the jechanivm by which acren
high density range by a receptor-mediated process with endocytosis and degradation. These observations our is designed to (1) What properties the lipoprotein are responsible for "HDL recognition and cholesterol uptake? (2) What is the mechanism by which adren
 high density range by a receptOr-mediated ProceSs nOt aSsOciaTed wIth lipoprotein ENdocYtosis and lysosomal degrAdatiOn. tHese OBsErvatIons raiSE tWO MajOr QuEstIoNS wHich oUr pRoposal Is designed To aNsWer: (1) What propeRTiEs of the lipOprOtein are respOnsIble foR "HdL rECeptoR" reCogniTion anD CholesTerol uptaKe? (2) wHat is tHE mechanISM bY whiCh adren
 high density range by a r eceptor-me diate d p roc es s no t as sociated withl ipop rotein endocytosis and  lyso so m al d e gr adati on. The s eo b ser va ti ons  r a is e two  ma jor que stions whi chou r proposal i s  d esigned to  an swer: (1) Wh atproper ti eso f the  li popro tein a r e resp onsible f or "HDL r e ceptor" r ec ogni tion and choleste r ol uptake? (2) Wh at isth e  m e c han ism  by whichad ren
 high_density range_by a receptor-mediated process_not associated_with_lipoprotein endocytosis_and_lysosomal degradation. These_observations raise two_major questions which our_proposal is designed_to_answer: (1) What properties of the lipoprotein are responsible for "HDL receptor" recognition and_cholesterol_uptake? (2)_What_is_the mechanism by which adren