 treatment with cisplatin and IR is well-tolerated and leads to durable responses in mouse xenograft and genetic models of lung cancer. Quite unexpectedly, we show that in addition to potentiating DNA damage, two clinical ATR kinase inhibitors (ATRi?s), with unrelated structures, block expression of the immune checkpoint protein PD
treatment with cisplatin and IR is well - tolerated and leads to durable responses in shiner heterograft and genic models of lung cancer. Quite by chance, we show that in summation to potentiating DNA price, two clinical ATR kinase inhibitors (ATRi?s), with unrelated structures, forget expression of the immune checkpoint protein PD
 trfatment with cisplatin akd IR is well-tolgrqted aid leada to durxble responses in mouse xenojrafr and genetic models of lune cancer. Euite unwxpertedly, we show tizt in additioh to 'oventiating DNA camage, two clinical ATR nivade inhibitors (ATRi?s), with unrelated ftructuted, block expresfion jf tgv lmmune checkpoint protein PD
treatment with cisplatin and IR is well-tolerated to responses in xenograft and genetic unexpectedly, show that in to potentiating DNA two clinical ATR kinase inhibitors (ATRi?s), unrelated structures, block expression of the immune checkpoint protein PD
 treatment with cisplatin and iR is well-toLeratEd aNd lEaDs to DuraBle responses in MOuse Xenograft and genetic modEls of LuNG canCEr. quite UnexpecTEdLY, We sHoW tHat In ADdItion To pOtentiaTing DNA damAge, TwO clinical ATR KInAse inhibitOrs (aTRi?s), with unrElaTed strUcTurES, blocK exPressIon of tHE immunE checkpoiNt PRotein pd
 treatment with cisplatinand IR iswell- tol era te d an d le ads to durable resp onses in mouse xenogra ft an dg enet i cmodel s of lu n gc a nce r.  Q uit eu ne xpect edl y, we s how that i n a dd ition to pot e nt iating DNA  da mage, two cl ini cal AT Rkin a se in hib itors  (ATRi ? s), wi th unrela te d  struc t ures, b l o ck  exp ression of the im m un e  checkpoint pr oteinPD 
 treatment_with cisplatin_and IR is well-tolerated_and leads_to_durable responses_in_mouse xenograft and_genetic models of_lung cancer. Quite unexpectedly,_we show that_in_addition to potentiating DNA damage, two clinical ATR kinase inhibitors (ATRi?s), with unrelated structures,_block_expression of_the_immune_checkpoint protein PD