 increased mutations of the key DNA damage regulator, p53, which is known to augment the SASP response. Moreover, we will determine whether dermal fibroblasts or epidermal keratinocytes in early hyperemic foci exhibit a senescence marker, heterochromatin protein 1g (HP1g), and markers of double stranded DNA breaks,
increased mutations of the key DNA damage governor, p53, which is know to augment the SASP response. Moreover, we will settle whether cutaneous fibroblasts or epidermal keratinocytes in early hyperemic foci expose a senescence marker, heterochromatin protein 1 g (HP1 g), and markers of bivalent ground DNA break,
 infreased mutations of the key DNA damage regulavor, p53, wgich is ynown to augment the SASP redpinse. Noreover, we will deteroine whetjer dermql fmbroblasts or epmsermal keratihlcytzs in early hypetemic foci efhibit a seneswevcz marker, heterochromatin protein 1g (H[1g), and kagkers of doublg strsgded DNA breaks,
increased mutations of the key DNA damage which known to the SASP response. dermal or epidermal keratinocytes early hyperemic foci a senescence marker, heterochromatin protein 1g and markers of double stranded DNA breaks,
 increased mutations of the keY DNA damage RegulAtoR, p53, wHiCh is KnowN to augment the SasP reSponse. Moreover, we will deTermiNe WHethER dErmal FibroblAStS OR epIdErMal KeRAtInocyTes In early Hyperemic fOci ExHibit a senescENcE marker, hetEroChromatin proTeiN 1g (HP1g), aNd MarKErs of DouBle stRanded dnA breaKs,
 increased mutations of th e key DNAdamag e r egu la tor,  p53 , which is kno w n to  augment the SASP resp onse.  M o reov e r,  we w ill det e rm i n e w he th erde r ma l fib rob lasts o r epiderma l k er atinocytes i n  e arly hyper emi c foci exhib ita sene sc enc e  mark er,  hete rochro m atin p rotein 1g  ( H P1g),a nd mark e r sof d ouble stranded DN A  b r eaks,
 increased_mutations of_the key DNA damage_regulator, p53,_which_is known_to_augment the SASP_response. Moreover, we_will determine whether dermal_fibroblasts or epidermal_keratinocytes_in early hyperemic foci exhibit a senescence marker, heterochromatin protein 1g (HP1g), and markers_of_double stranded_DNA_breaks,