PLA2 KO mice. Changes in stromal cells will be defined and in vitro co-cultures will examine cross-talk between cancer cells and macrophages. Aim 2 will use genetic mice to define the downstream effectors of cPLA2 in the tumor microenvironment. These studies will provide a better understanding of tumor-stromal interactions
PLA2 KO mice. Changes in stromal cells will be defined and in vitro conscientious objector - acculturation will examine cross - talk between cancer cell and macrophages. Aim 2 will practice genetic mice to define the downstream effecter of cPLA2 in the tumor microenvironment. These studies will provide a good understanding of tumor - stromal interaction
PLA2 KO mice. Changes in strooal cells will yw defiied and in vitru co-cultures will examine crlsw-talk between cancer cells xnd macroihages. Ain 2 wmll use genetic mice to define bhe dmxnstream effectprs of cPLD2 in the tumor mkcxoenvironment. These studies will prodide a nehter understanqing jf thmor-stromal interactions
PLA2 KO mice. Changes in stromal cells defined in vitro will examine cross-talk Aim will use genetic to define the effectors of cPLA2 in the tumor These studies will provide a better understanding of tumor-stromal interactions
PLA2 KO mice. Changes in stromal Cells will bE defiNed And In VitrO co-cUltures will exaMIne cRoss-talk between cancer cElls aNd MAcroPHaGes. AiM 2 will usE GeNETic MiCe To dEfINe The doWnsTream efFectors of cpLA2 In The tumor micrOEnVironment. THesE studies will ProVide a bEtTer UNdersTanDing oF tumor-STromal InteractiOnS
PLA2 KO mice. Changes in s tromal cel ls wi llbede fine d an d in vitro co- c ultu res will examine cross -talk  b e twee n  c ancer  cellsa nd m acr op ha ges .A im  2 wi lluse gen etic micetode fine the dow n st ream effec tor s of cPLA2 i n t he tum or  mi c roenv iro nment . Thes e  studi es will p ro v ide ab etter u n d er stan ding of tumor-str o ma l  interactions
PLA2 KO_mice. Changes_in stromal cells will_be defined_and_in vitro_co-cultures_will examine cross-talk_between cancer cells_and macrophages. Aim 2_will use genetic_mice_to define the downstream effectors of cPLA2 in the tumor microenvironment. These studies will_provide_a better_understanding_of_tumor-stromal interactions