CRR (TopBP1-interacting checkpoint and replication regulator). TICRR interacts with the first two BRCT domains of TopBP1 and is required for DNA replication initiation and cell cycle arrest following DNA damage. The second Aim is focused on identifying and characterizing novel TopBP1 and TICRR protein interactions. The
CRR (TopBP1 - interacting checkpoint and replication regulator). TICRR interacts with the inaugural two BRCT domain of TopBP1 and is required for DNA replication trigger and cell cycle apprehension following DNA damage. The second purpose is focused on identifying and characterize novel TopBP1 and TICRR protein interactions. The
CRR (TopBP1-interacting checkpuint and repliccrion rxgulatod). TICRR knteracts with the first two BECT dimains of TopBP1 and is required for DNA repoucation inmfiation and cspl cvcoe arrest follpwing DNA gamage. The secmna Cim is focused on identifying and chwracterozlng novel TopBK1 and EICRD protein interactions. The
CRR (TopBP1-interacting checkpoint and replication regulator). TICRR the two BRCT of TopBP1 and initiation cell cycle arrest DNA damage. The Aim is focused on identifying and novel TopBP1 and TICRR protein interactions. The
CRR (TopBP1-interacting checkpOint and repLicatIon RegUlAtor). tICRr interacts with THe fiRst two BRCT domains of TopbP1 and Is REquiREd For DNa replicATiON IniTiAtIon AnD CeLl cycLe aRrest foLlowing DNA DamAgE. The second AiM Is Focused on iDenTifying and chAraCterizInG noVEl TopbP1 aNd TICrR protEIn inteRactions. THe
CRR (TopBP1-interacting ch eckpoint a nd re pli cat io n re gula tor). TICRR in t erac ts with the first twoBRCTdo m ains of  TopB P1 andi sr e qui re dfor  D N Arepli cat ion ini tiation an d c el l cycle arre s tfollowingDNA  damage. The  se cond A im  is focus edon id entify i ng and  characte ri z ing no v el TopB P 1  a nd T ICRR protein inte r ac t ions. The
CRR (TopBP1-interacting_checkpoint and_replication regulator). TICRR interacts_with the_first_two BRCT_domains_of TopBP1 and_is required for_DNA replication initiation and_cell cycle arrest_following_DNA damage. The second Aim is focused on identifying and characterizing novel TopBP1 and_TICRR_protein interactions._The