 in the cell cycle, including the expression of p53, the retinoblastoma suppressor protein (pRb), and enzymes directly required for initiating DNA synthesis. We anticipate that the results of these experiments will shed further light on both the mechanisms generating increased levels of guanine nucleotides in proliferating cells and the sequelae of reductions in
in the cell cycle, including the expression of p53, the retinoblastoma suppressor protein (pRb), and enzyme immediately want for initiating DNA deduction. We anticipate that the resultant role of these experiments will shed further luminosity on both the mechanisms generating increase levels of guanine nucleotides in proliferate cells and the sequelae of reduction in
 in the cell cycle, includinn the expression of p53, tie retihoblastooa suppressor protein (pRb), anv enzymes directly required for initiatijg DNA stnthtsis. We anticipatx that tmz reshpts mh these experimgnts will shad further ligvt ou both the mechanisms generating incweased kegels of guaning nuckqotisvs in proliferating cells and tge sequtlae of reductions in
in the cell cycle, including the expression the suppressor protein and enzymes directly We that the results these experiments will further light on both the mechanisms increased levels of guanine nucleotides in proliferating cells and the sequelae of reductions
 in the cell cycle, including thE expressioN of p53, tHe rEtiNoBlasToma Suppressor protEIn (pRB), and enzymes directly reqUired FoR InitIAtIng DNa syntheSIs. wE AntIcIpAte ThAT tHe resUltS of thesE experimenTs wIlL shed further LIgHt on both thE meChanisms geneRatIng incReAseD LevelS of GuaniNe nuclEOtides In prolifeRaTIng celLS and the SEQuElae Of reductions in
 in the cell cycle, includ ing the ex press ion  of  p 53,theretinoblastoma supp ressor protein (pRb),and e nz y mesd ir ectly  requir e df o r i ni ti ati ng DN A syn the sis. We  anticipat e t ha t the result s  o f these ex per iments willshe d furt he r l i ght o n b oth t he mec h anisms  generati ng increa s ed leve l s  o f gu anine nucleotides in proliferatingcellsan d  t h e  se que lae of red uc tions in
 in_the cell_cycle, including the expression_of p53,_the_retinoblastoma suppressor_protein_(pRb), and enzymes_directly required for_initiating DNA synthesis. We_anticipate that the_results_of these experiments will shed further light on both the mechanisms generating increased levels_of_guanine nucleotides_in_proliferating_cells and the sequelae of_reductions in