 concern the relationship of its domain structure to its biological function, its molecular and cellular interactions, the elucidation of pathways for activation of FXI, and the expression and regulation of its enzymatic activity. It is hoped that information gleaned from the proposed studies will result in novel approaches to targeting FXI/XIa in the
concern the relationship of its domain structure to its biological affair, its molecular and cellular interaction, the elucidation of pathways for activation of FXI, and the formulation and regulation of its enzymatic activity. It is hop that information gleaned from the propose studies will result in fresh approaches to targeting FXI / XIa in the
 cojcern the relationship on its domain strocrure tm its giologicxl function, its molecular anv ceolulae interactions, the eluzidation lf pathwqys hor activation oh FXI, and the swpresvmon and regulatlon of its anzymatic actieigy. It is hoped that information gleanqd from tje proposed stodies rill gewult in novel approaches to tzrgetinj FXI/XIa in the
concern the relationship of its domain structure biological its molecular cellular interactions, the of and the expression regulation of its activity. It is hoped that information from the proposed studies will result in novel approaches to targeting FXI/XIa in
 concern the relationship of iTs domain stRuctuRe tO itS bIoloGicaL function, its moLEculAr and cellular interactiOns, thE eLUcidATiOn of pAthways FOr ACTivAtIoN of fXi, AnD the eXprEssion aNd regulatiOn oF iTs enzymatic aCTiVity. It is hoPed That informatIon GleaneD fRom THe proPosEd stuDies wiLL resulT in novel aPpROaches TO targetING FxI/XIA in the
 concern the relationshipof its dom ain s tru ctu re  toitsbiological fun c tion , its molecular and ce llula ri nter a ct ions,  the el u ci d a tio nof  pa th w ay s for  ac tivatio n of FXI,and  t he expressio n  a nd regulat ion  of its enzy mat ic act iv ity .  It i s h opedthat i n format ion glean ed from t h e propo s e dstud ies will result i n  n o vel approaches  to ta rg e ti n g  FX I/X Ia in the
 concern_the relationship_of its domain structure_to its_biological_function, its_molecular_and cellular interactions,_the elucidation of_pathways for activation of_FXI, and the_expression_and regulation of its enzymatic activity. It is hoped that information gleaned from the_proposed_studies will_result_in_novel approaches to targeting FXI/XIa_in the