 expressed with a particular variable region via a distinct recombination process termed class switch recombination (CSR). At this stage, the variable region coding sequence may be further altered by somatic hypermutation (SM). While the nature of the enzymes that initiate CSR or SM remains elusive, both processes, like V(D)J
expressed with a particular variable region via a discrete recombination procedure termed class switch recombination (CSR). At this degree, the variable region tease succession may be further altered by somatic hypermutation (SM). While the nature of the enzymes that lead up CSR or SM remains elusive, both process, like V(D)J
 exoressed with a particulav variable regiou via a distihct recoobination process termed clads switxh recombination (CSR). Ag this stwge, the carieble region codiif sequekee mag be yucther altered bi somatic hy[ermutation (SM). Wfipe the nature of the enzymes that igitiate CDR or SM remaigs ektsivs, both processes, like V(D)J
expressed with a particular variable region via recombination termed class recombination (CSR). At coding may be further by somatic hypermutation While the nature of the enzymes initiate CSR or SM remains elusive, both processes, like V(D)J
 expressed with a particular vAriable regIon viA a dIstInCt reCombInation process TErmeD class switch recombinatIon (CSr). AT This STaGe, the VariablE ReGIOn cOdInG seQuENcE may bE fuRther alTered by somAtiC hYpermutation (sm). WHile the natUre Of the enzymes ThaT initiAtE CSr Or SM rEmaIns elUsive, bOTh procEsses, like v(D)j
 expressed with a particul ar variabl e reg ion  vi aa di stin ct recombinati o n pr ocess termed class swi tch r ec o mbin a ti on (C SR). At th i s  st ag e,  th ev ar iable  re gion co ding seque nce  m ay be furthe r  a ltered bysom atic hypermu tat ion (S M) . W h ile t henatur e of t h e enzy mes thatin i tiateC SR or S M re main s elusive, both p r oc e sses, like V(D )J
 expressed_with a_particular variable region via_a distinct_recombination_process termed_class_switch recombination (CSR)._At this stage,_the variable region coding_sequence may be_further_altered by somatic hypermutation (SM). While the nature of the enzymes that initiate CSR_or_SM remains_elusive,_both_processes, like V(D)J