 this project is to understand at the molecular level the mechanism by which steroid hormones affect the expression of the genome of their target cells. We have chosen to investigate the cytolytic response of murine lymphoid cell lines to glucocorticoids because this system presents unique and desirable features. Since variants resistant to the steroid can conveniently be isolated, this
this project is to understand at the molecular level the mechanism by which steroid hormone involve the expression of the genome of their target cell. We have choose to investigate the cytolytic response of murine lymphoid cell note to glucocorticoid because this system presents unique and desirable features. Since variants repellent to the steroid can conveniently be isolate, this
 thls project is to understxnd at the moleeylar lxvel ths mechanksm by which steroid hormoned qffecu the expression of the genole of thwir uarget cells. We hebe choscu to jkvestngete the cytolytlc response of murine lym[huib cell lines to glucocorticoids becatse thix dystem presentf unpqte ahd desirable features. Since varianfs resivtant to the xteroid can conveniently bf isllated, this
this project is to understand at the the by which hormones affect the their cells. We have to investigate the response of murine lymphoid cell lines glucocorticoids because this system presents unique and desirable features. Since variants resistant to steroid can conveniently be isolated, this
 this project is to understand At the molecUlar lEveL thE mEchaNism By which steroid HOrmoNes affect the expression Of the GeNOme oF ThEir taRget celLS. WE HAve ChOsEn tO iNVeStigaTe tHe cytolYtic responSe oF mUrine lymphoiD CeLl lines to gLucOcorticoids bEcaUse thiS sYstEM presEntS uniqUe and dESirablE features. siNCe variANts resiSTAnT to tHe steroid can conveNIeNTly be isolated, tHis
 this project is to unders tand at th e mol ecu lar  l evel  the  mechanism byw hich  steroid hormones affe ct th ee xpre s si on of  the ge n om e ofth ei r t ar g et  cell s.We have  chosen to  in ve stigate thec yt olytic res pon se of murine  ly mphoid  c ell lines  to  gluc ocorti c oids b ecause th is system present s un ique  and desirable fe a tu r es. Since vari ants r es i st a n t t o t he steroid  c an co n venient l yb e iso l ated, this
 this_project is_to understand at the_molecular level_the_mechanism by_which_steroid hormones affect_the expression of_the genome of their_target cells. We_have_chosen to investigate the cytolytic response of murine lymphoid cell lines to glucocorticoids because_this_system presents_unique_and_desirable features. Since variants resistant_to the steroid can conveniently_be isolated,_this