 now propose to test the hypothesis that reduction in hepatic CEACAM1 underlies the causative role of hyperinsulinemia in diet-induced insulin resistance. To this end, we will in Aim 1, investigate whether preventing hyperinsulinemia curbs diet-induced insulin resistance in a model of hepatic Ceacam1 gain-
now propose to test the hypothesis that decrease in hepatic CEACAM1 underlie the causative role of hyperinsulinemia in diet - induced insulin underground. To this conclusion, we will in Aim 1, investigate whether preventing hyperinsulinemia curbs diet - induce insulin resistor in a model of hepatic Ceacam1 gain-
 noa propose to test the hykothesis that redocrion ii hepatjc CEACAO1 underlies the causative rope of htperinsulinemia in dieg-induced pnsulin rwsisuance. To this end, we will in Aij 1, inrewtigate whethet preventing hyperinsulinekix eurbs diet-induced insulin resistance in a mpdfl of hepatic Seacsi1 gajn-
now propose to test the hypothesis that hepatic underlies the role of hyperinsulinemia this we will in 1, investigate whether hyperinsulinemia curbs diet-induced insulin resistance in model of hepatic Ceacam1 gain-
 now propose to test the hypothEsis that reDuctiOn iN hePaTic CeACAm1 underlies the cAUsatIve role of hyperinsulineMia in DiET-indUCeD insuLin resiSTaNCE. To ThIs End, We WIlL in AiM 1, inVestigaTe whether pRevEnTing hyperinsULiNemia curbs DieT-induced insuLin ResistAnCe iN A modeL of HepatIc CeacAM1 gain-
 now propose to test the h ypothesisthatred uct io n in  hep atic CEACAM1 u n derl ies the causative role  of h yp e rins u li nemia  in die t -i n d uce din sul in re sista nce . To th is end, we  wi ll  in Aim 1, i n ve stigate wh eth er preventin g h yperin su lin e mia c urb s die t-indu c ed ins ulin resi st a nce in a model o fhepa tic Ceacam1 gain- 
 now_propose to_test the hypothesis that_reduction in_hepatic_CEACAM1 underlies_the_causative role of_hyperinsulinemia in diet-induced_insulin resistance. To this_end, we will_in_Aim 1, investigate whether preventing hyperinsulinemia curbs diet-induced insulin resistance in a model of_hepatic_Ceacam1 gain-