 is to test the hypothesis that expression and localization of specific subunits of the GABAAR are altered during postnatal development in a mouse model of FXS and that these changes are associated with functional deficits, including increased neuronal excitability and altered anxiety- related behavior. Specific Aim 1 will identify changes in the 12 subunit of the GABAAR
is to test the hypothesis that expression and localization of specific fractional monetary unit of the GABAAR are alter during postnatal development in a mouse exemplar of FXS and that these change are associated with functional deficit, admit increased neural excitability and alter anxiety- related behavior. Specific Aim 1 will name changes in the 12 subunit of the GABAAR
 is to test the hypothesis uhat expression aue locanizatikn of spdcific subunits of the GABAAC arw alttged during postnatal aevelopmejt in a noust model of FXS anv that tmzse cgwngev are associatec with funwtional deficids, iucluding increased neuronal excitabijity anc wltered anxieti- relseed gvhcvior. Specific Aim 1 will identiry chanjes in the 12 subinit of the GABAAR
is to test the hypothesis that expression of subunits of GABAAR are altered mouse of FXS and these changes are with functional deficits, including increased neuronal and altered anxiety- related behavior. Specific Aim 1 will identify changes in the subunit of the GABAAR
 is to test the hypothesis that Expression And loCalIzaTiOn of SpecIfic subunits of THe GAbAAR are altered during poStnatAl DEvelOPmEnt in A mouse mODeL OF FXs aNd ThaT tHEsE chanGes Are assoCiated with FunCtIonal deficitS, InCluding incReaSed neuronal eXciTabiliTy And ALtereD anXiety- RelateD BehaviOr. SpecifiC AIM 1 will iDEntify cHANgEs in The 12 subunit of the GAbaAr
 is to test the hypothesis  that expr essio n a ndlo cali zati on of specific subu nits of the GABAAR are  alte re d  dur i ng  post natal d e ve l o pme nt  i n a  m o us e mod elof FXSand that t hes echanges area ss ociated wi thfunctional d efi cits,in clu d ing i ncr eased  neuro n al exc itability  a n d alte r ed anxi e t y-  rel ated behavior. Sp e ci f ic Aim 1 willidenti fy ch a n ges  in  the 12 su bu nit o f  the GA B AA R 
 is_to test_the hypothesis that expression_and localization_of_specific subunits_of_the GABAAR are_altered during postnatal_development in a mouse_model of FXS_and_that these changes are associated with functional deficits, including increased neuronal excitability and altered_anxiety-_related behavior._Specific_Aim_1 will identify changes in_the 12 subunit of the_GABAAR