, the CFTR (-/-) knockout mouse. Interestingly, the CFTR (-/-) mouse did not exhibit a severe CF phenotype in many epithelial tissues, including the airways. Importantly, the absence of a CF phenotype led to the formal identification of the Ca2+-regulated, or "alternative" Cl- conduction
, the CFTR (-/-) knockout mouse. Interestingly, the CFTR (-/-) mouse did not exhibit a severe CF phenotype in many epithelial tissues, include the respiratory tract. Importantly, the absence of a CF phenotype led to the formal identification of the Ca2 + -regulated, or " alternate " Cl- conduction
, thf CFTR (-/-) knockout mouse. Ikterestingly, the CFTR (-/-) kouse sid not dxhibit a severe CF phenotypx in many epithelial tissues, inzluding tje airwats. Inportantly, vge absekee of w CF 'henotype led tp the formdl identificathov lf the Ca2+-regulated, or "alternative" Cj- conduvtlon
, the CFTR (-/-) knockout mouse. Interestingly, (-/-) did not a severe CF including airways. Importantly, the of a CF led to the formal identification of Ca2+-regulated, or "alternative" Cl- conduction
, the CFTR (-/-) knockout mouse. InterEstingly, thE CFTR (-/-) MouSe dId Not eXhibIt a severe CF pheNOtypE in many epithelial tissuEs, incLuDIng tHE aIrwayS. ImportANtLY, The AbSeNce Of A cF PhenoTypE led to tHe formal idEntIfIcation of the cA2+-rEgulated, or "AltErnative" Cl- coNduCtion
, the CFTR (-/-) knockoutmouse. Int erest ing ly,  t he C FTR(-/-) mouse di d  not  exhibit a severe CF p henot yp e  inm an y epi thelial ti s s ues ,in clu di n gthe a irw ays. Im portantly,  th eabsence of a CF  phenotype  le d to the for mal  ident if ica t ion o f t he Ca 2+-reg u lated,  or "alte rn a tive"C l- cond u c ti on
, the_CFTR (-/-)_knockout mouse. Interestingly, the_CFTR (-/-)_mouse_did not_exhibit_a severe CF_phenotype in many_epithelial tissues, including the_airways. Importantly, the_absence_of a CF phenotype led to the formal identification of the Ca2+-regulated, or "alternative"_Cl-_conduction