 will determine the effect of increasing AGE on fatigue life and fracture toughness, the ability to resist crack propagation. Aim 3 will assess the efficacy of pyridoxamine and N-acetylcysteine to increase fracture resistance of bone in an aging rat model of T2D through changes in bone structure, BMD, and
will determine the effect of increasing AGE on fatigue duty biography and fracture toughness, the ability to resist shot generation. Aim 3 will assess the efficacy of pyridoxamine and N - acetylcysteine to increase fracture electric resistance of bone in an aging rat exemplar of T2D through changes in bone structure, BMD, and
 wipl determine the effect uf increasing AYW on fetigue mife and fracture toughness, the abilmty ro rewist crack propagation. Aim 3 wilp assess the wfficacy oh pyridowcmine wnd U-aretylcysteine tp increase fracture resivtxnee of bone in an aging rat model of E2D throigj changes in bjne xerucflrt, BMD, and
will determine the effect of increasing AGE life fracture toughness, ability to resist assess efficacy of pyridoxamine N-acetylcysteine to increase resistance of bone in an aging model of T2D through changes in bone structure, BMD, and
 will determine the effect of iNcreasing AgE on fAtiGue LiFe anD fraCture toughness, THe abIlity to resist crack propAgatiOn. aIm 3 wiLL aSsess The effiCAcY OF pyRiDoXamInE AnD N-aceTylCysteinE to increasE frAcTure resistanCE oF bone in an aGinG rat model of T2d thRough cHaNgeS In bonE stRuctuRe, BMD, aND
 will determine the effect  of increa singAGE  on  f atig ue l ife and fractu r e to ughness, the ability t o res is t  cra c kpropa gation. Ai m 3 w il lass es s  t he ef fic acy ofpyridoxami nean d N-acetylcy s te ine to inc rea se fractureres istanc eofb one i n a n agi ng rat modelof T2D th ro u gh cha n ges inb o ne  str ucture, BMD, and
 will_determine the_effect of increasing AGE_on fatigue_life_and fracture_toughness,_the ability to_resist crack propagation._Aim 3 will assess_the efficacy of_pyridoxamine_and N-acetylcysteine to increase fracture resistance of bone in an aging rat model of_T2D_through changes_in_bone_structure, BMD, and