 be generated in which ADAR2 levels have been altered by over expression or by selective ablation of ADAR2 auto editing. Multiple, independent mouse lines will be assessed for gross alterations in animal phenotype, changes in the level of ADAR2 expression/activity, alterations in editing patterns for previously identified ADAR2 substrates and
be generated in which ADAR2 levels have been altered by over expression or by selective ablation of ADAR2 car editing. Multiple, autonomous shiner lines will be assessed for gross alteration in animal phenotype, changes in the level of ADAR2 construction / activeness, alterations in edit patterns for previously identified ADAR2 substrate and
 be generated in which ADAR2 levels have begn alterxd by ober exprdssion or by selective ablatmon if ADQR2 auto editing. Multipue, indepejdent moyse ounes will us assessed fod grovw alterations ln animal pvenotype, changas iu the level of ADAR2 expression/activiey, altetahions in editigg pseterhs for previously identified ADAR2 aubstraues and
be generated in which ADAR2 levels have by expression or selective ablation of mouse will be assessed gross alterations in phenotype, changes in the level of expression/activity, alterations in editing patterns for previously identified ADAR2 substrates and
 be generated in which ADAR2 levEls have beeN alteRed By oVeR expRessIon or by selectiVE ablAtion of ADAR2 auto editing. multiPlE, IndePEnDent mOuse linES wILL be AsSeSseD fOR gRoss aLteRations In animal phEnoTyPe, changes in tHE lEvel of ADAR2 ExpRession/activIty, AlteraTiOns IN editIng PatteRns for PReviouSly identiFiED ADAR2 sUBstrateS ANd
 be generated in which ADA R2 levelshavebee n a lt ered  byover expressio n  orby selective ablationof AD AR 2  aut o  e ditin g. Mult i pl e ,  in de pe nde nt mo use l ine s willbe assesse d f or  gross alter a ti ons in ani mal  phenotype,cha nges i nthe level  of  ADAR 2 expr e ssion/ activity,  a l terati o ns in e d i ti ng p atterns for previ o us l y identified A DAR2 s ub s tr a t esand 
 be_generated in_which ADAR2 levels have_been altered_by_over expression_or_by selective ablation_of ADAR2 auto_editing. Multiple, independent mouse_lines will be_assessed_for gross alterations in animal phenotype, changes in the level of ADAR2 expression/activity, alterations_in_editing patterns_for_previously_identified ADAR2 substrates and