 of in vivo studies (animal models and clinic data). Pathway-selective compounds could have functional selectivity. We also plan to demonstrate assay feasibility for HTS. Dr. Wei Zheng's group in NCATS will conduct the pilot screenings using the LOPAC library. Based on the results of the aim 4,
of in vivo studies (animal models and clinic data). Pathway - selective compound could take functional selectivity. We also plan to prove assay feasibility for HTS. Dr. Wei Zheng's group in NCATS will conduct the pilot screening use the LOPAC library. Based on the consequence of the aim 4,
 of in vivo studies (animal oodels and clinnx data). Pathwzy-selectkve compounds could have funrtiobal stjectivity. We also olan to dvmonstratw aswqy feasibility for HTS. Dd. Wei Vheng's group in NCATS wiln conduct the [iuoc screenings using the LOPAC library. Based pn the results os tht aym 4,
of in vivo studies (animal models and Pathway-selective could have selectivity. We also for Dr. Wei Zheng's in NCATS will the pilot screenings using the LOPAC Based on the results of the aim 4,
 of in vivo studies (animal modeLs and cliniC data). patHwaY-sElecTive Compounds could HAve fUnctional selectivity. We Also pLaN To deMOnStratE assay fEAsIBIliTy FoR HTs. DR. weI ZhenG's gRoup in NcATS will coNduCt The pilot screENiNgs using thE LOpAC library. BaSed On the rEsUltS Of the Aim 4,
 of in vivo studies (anima l models a nd cl ini c d at a).Path way-selectivec ompo unds could have functi onalse l ecti v it y. We  also p l an t o d em on str at e  a ssayfea sibilit y for HTS.  Dr .Wei Zheng'sg ro up in NCAT S w ill conductthe  pilot  s cre e nings  us ing t he LOP A C libr ary. Base do n ther esultso f  t he a im 4,
 of_in vivo_studies (animal models and_clinic data)._Pathway-selective_compounds could_have_functional selectivity. We_also plan to_demonstrate assay feasibility for_HTS. Dr. Wei_Zheng's_group in NCATS will conduct the pilot screenings using the LOPAC library. Based on_the_results of_the_aim_4,