 to ligand binding. Ligand-induced proteolysis releases the intracellular portion of notch (ICN) and allow it to translocate to the nucleus, where its RAM and ankyrin-repeat domains interact with two additional factors, RBP-JK and mastermind (mami 1) to form a transcriptionally active
to ligand binding. Ligand - induced proteolysis releases the intracellular portion of pass (ICN) and leave it to translocate to the nucleus, where its RAM and ankyrin - repeat domains interact with two extra factors, RBP - JK and genius (mami 1) to form a transcriptionally active
 to ligand binding. Ligand-inauced proteolysnw releeses ths intracdllular portion of notch (ICN) abd aloow it to translocate go the nubleus, wheee ius RAM and ankyrii-depeat domaina intzrect with two adcitional fdctors, RBP-JK atd mcstermind (mami 1) to form a transcriptyonally aftive
to ligand binding. Ligand-induced proteolysis releases the of (ICN) and it to translocate RAM ankyrin-repeat domains interact two additional factors, and mastermind (mami 1) to form transcriptionally active
 to ligand binding. Ligand-induCed proteolYsis rEleAseS tHe inTracEllular portion OF notCh (ICN) and allow it to transLocatE tO The nUClEus, whEre its Ram aND AnkYrIn-RepEaT DoMains IntEract wiTh two additIonAl Factors, RBP-JK ANd Mastermind (MamI 1) to form a tranScrIptionAlLy aCTive
 to ligand binding. Ligand -induced p roteo lys isre leas es t he intracellul a r po rtion of notch (ICN) a nd al lo w  itt otrans locatet ot h e n uc le us,  w h er e its  RA M and a nkyrin-rep eat  d omains inter a ct  with twoadd itional fact ors , RBP- JK  an d  mast erm ind ( mami 1 )  to fo rm a tran sc r iption a lly act i v e
 to_ligand binding._Ligand-induced proteolysis releases the_intracellular portion_of_notch (ICN)_and_allow it to_translocate to the_nucleus, where its RAM_and ankyrin-repeat domains_interact_with two additional factors, RBP-JK and mastermind (mami 1) to form a transcriptionally active