 foundation for development of novel steroid-based drugs for the treatment of psychiatric disorders. The goal of the work described in these studies is to elucidate how critical extracellular and intracellular domains control signaling by notch receptors. The extracellular domains of all notches contain three iterated LIN12 repeats, which maintain notch receptors in their resting state prior
foundation for development of novel steroid - free-base drug for the treatment of psychiatric disorders. The finish of the work identify in these studies is to elucidate how critical extracellular and intracellular knowledge domain control signaling by pass receptor. The extracellular domains of all notch contain three iterated LIN12 repeat, which maintain notch receptors in their resting state prior
 fokndation for development of novel sterone-based drugs for the treatment of psychiatric didoeders. The goal of the work aescribed in thesw stndies is to elucmsate how critjgal ertcacellular and lntracelluldr domains condrul signaling by notch receptors. The evtracelkupar domains of all gotcgvs contain three iterated LIN12 rspeats, xhich maintain motch receptors in their rfstijg state prior
foundation for development of novel steroid-based drugs treatment psychiatric disorders. goal of the is elucidate how critical and intracellular domains signaling by notch receptors. The extracellular of all notches contain three iterated LIN12 repeats, which maintain notch receptors in resting state prior
 foundation for development oF novel sterOid-baSed DruGs For tHe trEatment of psychIAtriC disorders. The goal of the Work dEsCRibeD In These Studies IS tO ELucIdAtE hoW cRItIcal eXtrAcellulAr and intraCelLuLar domains coNTrOl signalinG by Notch receptoRs. THe extrAcEllULar doMaiNs of aLl notcHEs contAin three iTeRAted LIn12 Repeats, WHIcH maiNtain notch receptoRS iN Their resting stAte priOr
 foundation for developmen t of novel  ster oid -ba se d dr ugsfor the treatm e nt o f psychiatric disorder s. Th eg oalo fthe w ork des c ri b e d i nth ese  s t ud ies i s t o eluci date how c rit ic al extracell u la r and intr ace llular domai nscontro lsig n aling  by  notc h rece p tors.The extra ce l lulard omainso f  a ll n otches contain th r ee iterated LIN12  repea ts ,  w h i chmai ntain notc hrecep t ors int he i r res t ing state pri or
 foundation_for development_of novel steroid-based drugs_for the_treatment_of psychiatric_disorders._The goal of_the work described_in these studies is_to elucidate how_critical_extracellular and intracellular domains control signaling by notch receptors. The extracellular domains of all_notches_contain three_iterated_LIN12_repeats, which maintain notch receptors_in their resting state prior