 positional information needed for the establishment of the correct set of limb cartilages and bones. Gene targeting in mouse embryo-derived stem cells provides the means for generating mice with disruptions in each of these genes. The goal of this grant is to use gene targeting to undertake a systematic analysis of this gene complex and thereby directly
positional information needed for the establishment of the correct hardening of arm cartilages and bones. Gene target in mouse embryo - derive stem cell put up the means for generate mice with disruptions in each of these gene. The goal of this grant is to use gene targeting to contract a systematic analysis of this gene building complex and thereby directly
 poditional information neeaed for the estcvlishmxnt of fhe corrdct set of limb cartilages aid bines. Tene targeting in mousd embryo-dvrived stwm ctlls provides the means for gensvatiny nice with disroptions in edch of these gands. The goal of this grant is to use gqne tarbehing to undertwke s sysfvmctic analysis of this gene compmex and thereby direvtly
positional information needed for the establishment of set limb cartilages bones. Gene targeting provides means for generating with disruptions in of these genes. The goal of grant is to use gene targeting to undertake a systematic analysis of this complex and thereby directly
 positional information needEd for the esTabliShmEnt Of The cOrreCt set of limb carTIlagEs and bones. Gene targetinG in moUsE EmbrYO-dEriveD stem ceLLs PROviDeS tHe mEaNS fOr genEraTing micE with disruPtiOnS in each of theSE gEnes. The goaL of This grant is tO usE gene tArGetINg to uNdeRtake A systeMAtic anAlysis of tHiS Gene coMPlex and THErEby dIrectly
 positional information ne eded for t he es tab lis hm entof t he correct set of l imb cartilages and bon es. G en e  tar g et ing i n mouse em b r yo- de ri ved  s t em  cell s p rovides  the means  fo rgenerating m i ce  with disr upt ions in each  of  these  g ene s . The  go al of  thisg rant i s to usege n e targ e ting to u nd erta ke a systematic a n al y sis of this ge ne com pl e xa n d t her eby direct ly 
 positional_information needed_for the establishment of_the correct_set_of limb_cartilages_and bones. Gene_targeting in mouse_embryo-derived stem cells provides_the means for_generating_mice with disruptions in each of these genes. The goal of this grant is_to_use gene_targeting_to_undertake a systematic analysis of_this gene complex and thereby_directly