, I and II, are highly similar in amino acid composition and function, but appear to be regulated differently at the molecular level. The overall objective of this proposal is to elucidate the mechanisms regulating the expression of these two isoenzymes and to develop new approaches to the modulation the expression of the two gene products. In addition
, I and II, are highly similar in amino acid composition and function, but appear to be determine differently at the molecular degree. The overall objective of this proposal is to elucidate the mechanism regulating the expression of these two isoenzymes and to build up modern approaches to the transition the expression of the two gene products. In summation
, I wnd II, are highly similav in amino acid eimposivion ans functiun, but appear to be regulatev didferebtly at the molecular uevel. The overall objtctive of this proposal is to emmcidace the mechanismx regulatitg the expresshov lf these two isoenzymes and to devejop new aoproaches to tre mpqulafpok the expression of the two gene producus. In addition
, I and II, are highly similar acid and function, appear to be level. overall objective of proposal is to the mechanisms regulating the expression of two isoenzymes and to develop new approaches to the modulation the expression of two gene products. In addition
, I and II, are highly similar in aMino acid coMposiTioN anD fUnctIon, bUt appear to be reGUlatEd differently at the moleCular LeVEl. ThE OvErall ObjectiVE oF THis PrOpOsaL iS To EluciDatE the mecHanisms regUlaTiNg the expressIOn Of these two IsoEnzymes and to DevElop neW aPprOAches To tHe modUlatioN The expRession of ThE Two genE ProductS. iN aDditIon
, I and II, are highly sim ilar in am ino a cid  co mp osit ionand function,b ut a ppear to be regulateddiffe re n tlya tthe m olecula r  l e v el.  T he  ov er a ll  obje cti ve of t his propos alis  to elucidat e  t he mechani sms  regulatingthe  expre ss ion of th ese  twoisoenz y mes an d to deve lo p  new a p proache s to  the  modulation the e x pr e ssion of the t wo gen ep ro d u cts . I n addition 
, I_and II,_are highly similar in_amino acid_composition_and function,_but_appear to be_regulated differently at_the molecular level. The_overall objective of_this_proposal is to elucidate the mechanisms regulating the expression of these two isoenzymes and_to_develop new_approaches_to_the modulation the expression of_the two gene products. In_addition