 behaviors, wherein some stimulate ATP hydrolysis and are transported, while others stimulate ATP hydrolysis but are not transported. Other drugs inhibit P-gp without stimulating ATP hydrolysis. The mechanism by which different drugs elicit different behaviors is unclear. Specifically, the conformational changes that mediate communication between the nucleotide binding domains (NBDs) that hydroly
behaviors, wherein some stimulate ATP hydrolysis and are transported, while others stimulate ATP hydrolysis but are not enchant. early drugs inhibit phosphorus - gp without stimulate ATP hydrolysis. The mechanism by which different drug elicit different behaviors is ill-defined. Specifically, the conformational changes that mediate communication between the nucleotide bind domains (NBDs) that hydroly
 bejaviors, wherein some stioulate ATP hydrolysis end are transpofted, while others stimulate ETP yydrooysis but are not tranrported. Onher drugw iniibit P-gp withouv stimulating ZBP hybrilysis. The mecmanism by wvich different dfuys elicit different behaviors is uncjear. Sprclfically, the cjnfogmwtiohal changes that mediate communicafion beuween the nucleotice binding domains (NBDs) thwt hjdroly
behaviors, wherein some stimulate ATP hydrolysis and while stimulate ATP but are not without ATP hydrolysis. The by which different elicit different behaviors is unclear. Specifically, conformational changes that mediate communication between the nucleotide binding domains (NBDs) that hydroly
 behaviors, wherein some stimuLate ATP hydRolysIs aNd aRe TranSporTed, while others STimuLate ATP hydrolysis but arE not tRaNSporTEd. other Drugs inHIbIT p-gp WiThOut StIMuLatinG ATp hydrolYsis. The mecHanIsM by which diffEReNt drugs eliCit Different behAviOrs is uNcLeaR. speciFicAlly, tHe confORmatioNal changeS tHAt mediATe commuNICaTion Between the nucleotIDe BInding domains (NbDs) thaT hYDrOLY
 behaviors, wherein some s timulate A TP hy dro lys is  and  are  transported,w hile  others stimulate ATPhydro ly s is b u tare n ot tran s po r t ed.  O th erdr u gs  inhi bit  P-gp w ithout sti mul at ing ATP hydr o ly sis. The m ech anism by whi chdiffer en t d r ugs e lic it di fferen t  behav iors is u nc l ear. S p ecifica l l y,  the  conformational c h an g es that mediat e comm un i ca t i onbet ween the n uc leoti d e bindi n gd o m ain s  (NBDs) thathydroly
 behaviors,_wherein some_stimulate ATP hydrolysis and_are transported,_while_others stimulate_ATP_hydrolysis but are_not transported. Other_drugs inhibit P-gp without_stimulating ATP hydrolysis._The_mechanism by which different drugs elicit different behaviors is unclear. Specifically, the conformational changes_that_mediate communication_between_the_nucleotide binding domains (NBDs) that_hydroly