 and its receptors) in lung endothelial and epithelial cells, and fetal lung explants, even in extreme hyperoxia. We hypothesize that PHDi can decrease PHNby restoring the fetal VEGF/eNOS axis and improving perinatal surfactant homeostasis. We propose to examine effects of PHDi delivered antenatally or postnat
and its receptors) in lung endothelial and epithelial cells, and fetal lung explants, even in extreme hyperoxia. We hypothesize that PHDi can decrease PHNby restoring the fetal VEGF / eNOS bloc and better perinatal surfactant homeostasis. We propose to test impression of PHDi delivered antenatally or postnat
 anf its receptors) in lung tndothelial and ekirhelian cella, and fegal lung explants, even in exvremw hyptgoxia. We hypothesize ghat PHDi can deceeast PHNby restoring the fetal VEGR/cNOS cxms and improvinn perinatal surfactant hokeuscasis. We propose to examine effects jf PHDi dflivered antenwtalkr or iowtnat
and its receptors) in lung endothelial and and lung explants, in extreme hyperoxia. decrease restoring the fetal axis and improving surfactant homeostasis. We propose to examine of PHDi delivered antenatally or postnat
 and its receptors) in lung endoThelial and EpithEliAl cElLs, anD fetAl lung explants, EVen iN extreme hyperoxia. We hypOthesIzE That phDI can dEcrease phNBY ResToRiNg tHe FEtAl VEGf/eNoS axis aNd improvinG peRiNatal surfactANt HomeostasiS. We Propose to exaMinE effecTs Of Phdi delIveRed anTenataLLy or poStnat
 and its receptors) in lun g endothel ial a ndepi th elia l ce lls, and fetal lung  explants, even in ext remehy p erox i a.  We h ypothes i ze t hat  P HD i c an de creas e P HNby re storing th e f et al VEGF/eNOS ax is and imp rov ing perinata l s urfact an t h o meost asi s. We  propo s e to e xamine ef fe c ts ofP HDi del i v er ed a ntenatally or pos t na t 
 and_its receptors)_in lung endothelial and_epithelial cells,_and_fetal lung_explants,_even in extreme_hyperoxia. We hypothesize_that PHDi can decrease_PHNby restoring the_fetal_VEGF/eNOS axis and improving perinatal surfactant homeostasis. We propose to examine effects of PHDi_delivered_antenatally or_postnat