 cell culture model of mutant SOD1-linked ALS. 4) To determine whether Bcl-2 mediates mutant SOD1 mitochondrial translocation. 5) To study the correlation between mutant SOD1/Bcl-2-containing aggregates and ALS using transgenic ALS mice and patients. In this project, the investigators propose to study the pathophysiology
cell culture model of mutant SOD1 - linked ALS. 4) To settle whether Bcl-2 intercede mutant SOD1 mitochondrial translocation. 5) To study the correlation between mutant SOD1 / Bcl-2 - containing aggregate and ALS using transgenic ALS mouse and affected role. In this project, the research worker propose to study the pathophysiology
 cepl culture model of mutakt SOD1-linked ALS. 4) To devermine whether Bcl-2 mediates mutant SOD1 mitlcyondrual translocation. 5) To rtudy the correlarion vetween muvznt SOD1/Nel-2-confwiniug aggregates anc ALS usinc transgenic ANS mnce and patients. In this project, the investogwtors propose jo stldr ths pathophysiology
cell culture model of mutant SOD1-linked ALS. determine Bcl-2 mediates SOD1 mitochondrial translocation. between SOD1/Bcl-2-containing aggregates and using transgenic ALS and patients. In this project, the propose to study the pathophysiology
 cell culture model of mutant SoD1-linked ALs. 4) To deTerMinE wHethEr BcL-2 mediates mutanT sOD1 mItochondrial translocatIon. 5) To StUDy thE CoRrelaTion betWEeN MUtaNt sOd1/BcL-2-cONtAininG agGregateS and ALS usiNg tRaNsgenic ALS miCE aNd patients. in tHis project, thE inVestigAtOrs PRoposE to Study The patHOphysiOlogy
 cell culture model of mut ant SOD1-l inked  AL S.4)  Todete rmine whetherB cl-2  mediates mutant SOD1mitoc ho n dria l  t ransl ocation .  5 ) Tost ud y t he co rrela tio n betwe en mutantSOD 1/ Bcl-2-contai n in g aggregat esand ALS usin g t ransge ni c A L S mic e a nd pa tients .  In th is projec t, the in v estigat o r sprop ose to study thep at h ophysiology
 cell_culture model_of mutant SOD1-linked ALS._4) To_determine_whether Bcl-2_mediates_mutant SOD1 mitochondrial_translocation. 5) To_study the correlation between_mutant SOD1/Bcl-2-containing aggregates_and_ALS using transgenic ALS mice and patients. In this project, the investigators propose to_study_the pathophysiology