CNS); b) myelin breakdown leads to clinical disease; c) TMEV persists in the CNS for the life of the mouse; and, d) demyelination appears to be immune-mediated. Our studies during the initial grant period have defined genetic loci contributing to disease susceptibility, established an immune-mediated
CNS); b) myelin breakdown leads to clinical disease; c) TMEV persists in the CNS for the life of the shiner; and, d) demyelination appear to be immune - mediated. Our studies during the initial concession period have define genetic venue contributing to disease susceptibility, established an immune - intercede
CNS); b) myelin breakdown leadr to clinical dnwease; r) TMEV lersists in the CNS for the life of vhe nouse; and, d) demyelination aopears to be immube-meviated. Our studixa durinn the lniticl grant period mave defineg genetic loci cuncributing to disease susceptibility, qstablixhfd an immune-meqiattd
CNS); b) myelin breakdown leads to clinical TMEV in the for the life demyelination to be immune-mediated. studies during the grant period have defined genetic loci to disease susceptibility, established an immune-mediated
CNS); b) myelin breakdown leads tO clinical dIseasE; c) TmEV PeRsisTs in The CNS for the liFE of tHe mouse; and, d) demyelinatiOn appEaRS to bE ImMune-mEdiated. oUr STUdiEs DuRinG tHE iNitiaL grAnt periOd have defiNed GeNetic loci conTRiButing to diSeaSe susceptibiLitY, estabLiSheD An immUne-MediaTed
CNS); b) myelin breakdownleads to c linic aldis ea se;c) T MEV persists i n  the  CNS for the life of t he mo us e ; an d ,d) de myelina t io n app ea rs  to  b e  i mmune -me diated.  Our studi esdu ring the ini t ia l grant pe rio d have defin edgeneti cloc i  cont rib uting  to di s ease s usceptibi li t y, est a blished a nimmu ne-mediated
CNS); b)_myelin breakdown_leads to clinical disease;_c) TMEV_persists_in the_CNS_for the life_of the mouse;_and, d) demyelination appears_to be immune-mediated._Our_studies during the initial grant period have defined genetic loci contributing to disease susceptibility,_established_an immune-mediated