 cancer cells during mitosis, we will challenge traditional biochemical views of gene regulation by defining the pathological linkages between modifications in nuclear architecture and gene expression that are fundamental to the molecular etiology of tumorigenesis. RELEVANCE (See instructions): Changes in the overall shape and structure ofthe nucleus are pathological hallmarks of cancer cells that
cancer cells during mitosis, we will challenge traditional biochemical views of gene regulation by defining the diseased linkage between modifications in nuclear architecture and gene formula that are cardinal to the molecular etiology of tumorigenesis. RELEVANCE (See instructions ): Changes in the overall form and structure ofthe nucleus are diseased hallmark of cancer cells that
 cajcer cells during mitosir, we will challgnte travitionam biocheoical views of gene regulatiln by dtyining the pathologizal linkahes betwwen nidificatioia in nugjear wrchntxcture and gene expressiot that are fungaoeutal to the molecular etiology of tuiorigenrsls. RELEVANCE (Sge inxerucfpoks): Changes in the overall shape znd strlcture ofthe nuclrus are pathological hallmwrks of cancer cells tjat
cancer cells during mitosis, we will challenge views gene regulation defining the pathological architecture gene expression that fundamental to the etiology of tumorigenesis. RELEVANCE (See instructions): in the overall shape and structure ofthe nucleus are pathological hallmarks of cancer that
 cancer cells during mitosis, wE will challEnge tRadItiOnAl biOcheMical views of geNE regUlation by defining the paTholoGiCAl liNKaGes beTween moDIfICAtiOnS iN nuClEAr ArchiTecTure and Gene expresSioN tHat are fundamENtAl to the molEcuLar etiology oF tuMorigeNeSis. reLEVAnCE (see inStructIOns): ChaNges in the OvERall shAPe and stRUCtUre oFthe nucleus are patHOlOGical hallmarks Of cancEr CElLS ThaT
 cancer cells during mitos is, we wil l cha lle nge  t radi tion al biochemical view s of gene regulation b y def in i ng t h epatho logical li n k age sbe twe en mo dific ati ons innuclear ar chi te cture and ge n eexpression  th at are funda men tal to  t hem olecu lar  etio logy o f  tumor igenesis.  R E LEVANC E  (See i n s tr ucti ons): Changes int he overall shapeand st ru c tu r e  of the  nucleus a re  path o logical ha l l m ark s  of cancer ce lls that
 cancer_cells during_mitosis, we will challenge_traditional biochemical_views_of gene_regulation_by defining the_pathological linkages between_modifications in nuclear architecture_and gene expression_that_are fundamental to the molecular etiology of tumorigenesis. RELEVANCE (See instructions): Changes in the_overall_shape and_structure_ofthe_nucleus are pathological hallmarks of_cancer cells that