 The proposed experiments are aimed at the discovery of drug-like compounds that can target Shp2?s unique allosteric site, potentially providing highly selective Shp2 inhibitors that have not been realized through active-site- directed efforts. Also proposed are small-molecule-discovery efforts targeting two disease- causing Sh
The proposed experiments are aimed at the discovery of drug - like compound that can target Shp2?s alone allosteric site, potentially providing highly selective Shp2 inhibitors that have not been understand through active - site- directed efforts. besides proposed are small - molecule - discovery attempt targeting two disease- causing Sh
 Thf proposed experiments ave aimed at the buscovecy of ddug-like zompounds that can target Sh'2?s ubique allosteric site, potengially prlviding yighot selectivx Shp2 inmnbitodd thct have not been realized dhrough active-vige- directed efforts. Also proposed are small-mplfcule-discovery effpwts fargeting two disease- causing Sh
The proposed experiments are aimed at the drug-like that can Shp2?s unique allosteric Shp2 that have not realized through active-site- efforts. Also proposed are small-molecule-discovery efforts two disease- causing Sh
 The proposed experiments are Aimed at the DiscoVerY of DrUg-liKe coMpounds that can TArgeT Shp2?s unique allosteric sIte, poTeNTialLY pRovidIng highLY sELEctIvE SHp2 iNhIBiTors tHat Have not Been realizEd tHrOugh active-siTE- dIrected effOrtS. Also proposeD arE small-MoLecULe-disCovEry efForts tARgetinG two diseaSe- CAusing sH
 The proposed experimentsare aimedat th e d isc ov eryof d rug-like compo u ndsthat can target Shp2?s  uniq ue allo s te ric s ite, po t en t i all ypr ovi di n ghighl y s electiv e Shp2 inh ibi to rs that have no t been rea liz ed through a cti ve-sit e-  di r ected  ef forts . Also propos ed are sm al l -molec u le-disc o v er y ef forts targeting t w od isease- causin g Sh
 The_proposed experiments_are aimed at the_discovery of_drug-like_compounds that_can_target Shp2?s unique_allosteric site, potentially_providing highly selective Shp2_inhibitors that have_not_been realized through active-site- directed efforts. Also proposed are small-molecule-discovery efforts targeting two disease-_causing_Sh