 mature derivatives. If similar mechanisms are relevant for the cancer stem cell (CSC) model, then epigenetic modulation might enrich the CSC population, thereby facilitating CSC isolation and rigorous evaluation. To test this hypothesis, primary human cancer cells and liver cancer cell lines were treated with zebularine (ZEB), a
mature derivatives. If similar mechanisms are relevant for the cancer shank cellular telephone (CSC) model, then epigenetic modulation might enrich the CSC population, thereby facilitate CSC isolation and rigorous evaluation. To quiz this hypothesis, primary human cancer cell and liver cancer cellular telephone lines were treated with zebularine (ZEB), a
 mahure derivatives. If simiuar mechanisms cee relxvant fkr the cxncer stem cell (CSC) model, thxn epigentnic modulation might dnrich thv CSC popylatmon, thereby facilitating CSC iallatnoi and rigorous gvaluation. Tm test this hy[oghzsis, primary human cancer cells and jiver csnfer cell lines wert tweatsd with zebularine (ZEB), a
mature derivatives. If similar mechanisms are relevant cancer cell (CSC) then epigenetic modulation thereby CSC isolation and evaluation. To test hypothesis, primary human cancer cells and cancer cell lines were treated with zebularine (ZEB), a
 mature derivatives. If similaR mechanismS are rEleVanT fOr thE canCer stem cell (CSC) MOdel, Then epigenetic modulatiOn migHt ENricH ThE CSC pOpulatiON, tHERebY fAcIliTaTInG CSC iSolAtion anD rigorous eValUaTion. To test thIS hYpothesis, pRimAry human cancEr cElls anD lIveR CanceR ceLl linEs were TReated With zebulArINe (ZEB), a
 mature derivatives. If si milar mech anism s a rere leva nt f or the cancers temcell (CSC) model, then  epig en e ticm od ulati on migh t  e n r ich  t he  CS Cp op ulati on,  thereb y facilita tin gCSC isolatio n  a nd rigorou s e valuation. T o t est th is  hy p othes is,  prim ary hu m an can cer cells  a n d live r  cancer c el l li nes were treatedw it h  zebularine (Z EB), a 
 mature_derivatives. If_similar mechanisms are relevant_for the_cancer_stem cell_(CSC)_model, then epigenetic_modulation might enrich_the CSC population, thereby_facilitating CSC isolation_and_rigorous evaluation. To test this hypothesis, primary human cancer cells and liver cancer cell_lines_were treated_with_zebularine_(ZEB), a