 but development of novel therapies is hampered by limited insight into pathophysiological mechanisms as well as small patient groups and insufficiently developed animal models. Therefore the overall objective of this proposal is to increase our knowledge of the pathophysiology of FAO disorders by studying newly identified molecular mechanisms and metabolic pathways that contribute to the different disease presentations using well
but development of novel therapies is hampered by circumscribed penetration into pathophysiological mechanism as well as small patient group and insufficiently developed animal models. consequently the overall objective of this proposal is to increase our knowledge of the pathophysiology of FAO disorder by studying newly identified molecular mechanism and metabolic pathways that contribute to the unlike disease presentations using well
 buh development of novel tmerapies is hampgrwd by nimites insighg into pathophysiological merhanusms qs well as small patievt groups and insyffiriently developev animal modela. Thexehore the overalk objectiva of this propmsxl is to increase our knowledge of thq patholhjsiology of FAJ dixjrdeds by studying newly identified momecular mechanisms amd metabolic pathways that conhribute to the difverent diseqse [eesentations using well
but development of novel therapies is hampered insight pathophysiological mechanisms well as small animal Therefore the overall of this proposal to increase our knowledge of the of FAO disorders by studying newly identified molecular mechanisms and metabolic pathways that to the different disease presentations using well
 but development of novel therApies is hamPered By lImiTeD insIght Into pathophysiOLogiCal mechanisms as well as sMall pAtIEnt gROuPs and InsuffiCIeNTLy dEvElOpeD aNImAl modEls. therefoRe the overaLl oBjEctive of this PRoPosal is to iNcrEase our knowlEdgE of the PaThoPHysioLogY of FAo disorDErs by sTudying neWlY IdentiFIed moleCULaR mecHanisms and metabolIC pAThways that contRibute To THe DIFfeRenT disease prEsEntatIOns usinG WeLL
 but development of noveltherapiesis ha mpe red  b y li mite d insight into path ophysiological mechani sms a sw ella ssmall  patien t  g r o ups  a nd  in su f fi cient lydevelop ed animalmod el s. Therefore th e overallobj ective of th ispropos al  is to in cre ase o ur kno w ledgeof the pa th o physio l ogy ofF A Odiso rders by studying ne w ly identifiedmolecu la r  m e c han ism s and meta bo lic p a thwayst ha t c ont r ibute to thedifferent d i sea se pre se nta t ions u singwe l l
 but_development of_novel therapies is hampered_by limited_insight_into pathophysiological_mechanisms_as well as_small patient groups_and insufficiently developed animal_models. Therefore the_overall_objective of this proposal is to increase our knowledge of the pathophysiology of FAO_disorders_by studying_newly_identified_molecular mechanisms and metabolic pathways_that contribute to the different_disease presentations_using well