 cellular and molecular biology of asthma. Despite these successes, any effort to understand clinical asthma (or how asthma is initiated and propagated) must ultimately be undertaken or validated by studying human subjects with asthma. These human studies, however, are subject to considerable difficulty, including problems recruiting appropriate subjects, the clinical heterogeneity of asthma and the
cellular and molecular biology of asthma. Despite these successes, any effort to understand clinical asthma (or how asthma is initiate and propagate) must ultimately be undertaken or validated by studying human subject with asthma. These human studies, however, are subject to considerable trouble, including problems recruiting appropriate subject, the clinical heterogeneity of asthma and the
 ceplular and molecular biouogy of asthma. Bwspite these successds, any effort to understand rlinucal qsthma (or how asthma ir initiatvd and pripageted) must ultimavsly be mudertznen mc validated by xtudying hgman subjects figh asthma. These human studies, however, are sunjfct to considetable qiffjbuoty, including problems recruifing apkropriate subjects, the clinical heterogeneitj of asthma and the
cellular and molecular biology of asthma. Despite any to understand asthma (or how must be undertaken or by studying human with asthma. These human studies, however, subject to considerable difficulty, including problems recruiting appropriate subjects, the clinical heterogeneity of and the
 cellular and molecular bioloGy of asthma. despiTe tHesE sUcceSses, Any effort to undERstaNd clinical asthma (or how aSthma Is INitiATeD and pRopagatED) mUST ulTiMaTelY bE UnDertaKen Or validAted by studYinG hUman subjects WItH asthma. TheSe hUman studies, hOweVer, are SuBjeCT to coNsiDerabLe diffICulty, iNcluding pRoBLems reCRuiting APPrOpriAte subjects, the cliNIcAL heterogeneity Of asthMa ANd THE
 cellular and molecular bi ology of a sthma . D esp it e th esesuccesses, any effo rt to understand clini cal a st h ma ( o rhow a sthma i s  i n i tia te dand  p r op agate d)must ul timately b e u nd ertaken or v a li dated by s tud ying human s ubj ects w it h a s thma.  Th ese h uman s t udies,  however,  a r e subj e ct to c o n si dera ble difficulty, i n cl u ding problemsrecrui ti n ga p pro pri ate subjec ts , the clinica l  h e t e rog e neity of asth ma and the
 cellular_and molecular_biology of asthma. Despite_these successes,_any_effort to_understand_clinical asthma (or_how asthma is_initiated and propagated) must_ultimately be undertaken_or_validated by studying human subjects with asthma. These human studies, however, are subject to_considerable_difficulty, including_problems_recruiting_appropriate subjects, the clinical heterogeneity_of asthma and the