. However, data from patients has suggested the opposite, that IDO activity may actually be associated with the development of disease symptoms. Consistent with this, inhibitors of IDO reduce autoantibody titers and alleviate arthritis symptoms in a B cell-mediated mouse model of RA. These data support a role for IDO in exacerb
. However, data from patients has suggested the opposite, that IDO natural process may actually be consociate with the development of disease symptoms. Consistent with this, inhibitor of IDO reduce autoantibody titers and alleviate arthritis symptoms in a B cellular telephone - mediate mouse exemplar of RA. These data support a function for IDO in exacerb
. Hoaever, data from patients has suggested jhw oppovite, tgat IDO xctivity may actually be asslcuated with the development uf diseasv symptomw. Coisistent with thma, inhiblcors kn IDO ceduce autoantinody titers and alleviate aftkritis symptoms in a B cell-mediated iouse mpdfl of RA. These dats suplort a role for IDO in exacerb
. However, data from patients has suggested that activity may be associated with Consistent this, inhibitors of reduce autoantibody titers alleviate arthritis symptoms in a B mouse model of RA. These data support a role for IDO in exacerb
. However, data from patients haS suggested The opPosIte, ThAt IDo actIvity may actualLY be aSsociated with the develoPment Of DIseaSE sYmptoMs. ConsiSTeNT WitH tHiS, inHiBItOrs of iDO Reduce aUtoantibodY tiTeRs and alleviaTE aRthritis syMptOms in a B cell-mEdiAted moUsE moDEl of Ra. ThEse daTa suppORt a rolE for IDO in ExACerb
. However, data from patie nts has su ggest edthe  o ppos ite,  that IDO acti v itymay actually be associ atedwi t h th e  d evelo pment o f  d i s eas esy mpt om s .Consi ste nt with  this, inh ibi to rs of IDO re d uc e autoanti bod y titers and  al leviat eart h ritis  sy mptom s in a B cell -mediated  m o use mo d el of R A .  T hese  data support a r o le for IDO in exa cerb
. However,_data from_patients has suggested the_opposite, that_IDO_activity may_actually_be associated with_the development of_disease symptoms. Consistent with_this, inhibitors of_IDO_reduce autoantibody titers and alleviate arthritis symptoms in a B cell-mediated mouse model of_RA._These data_support_a_role for IDO in exacerb