 promote cancer progression. Based on previous studies and preliminary studies, we hypothesize that inflammatory chemokine expression in fibroblasts including CCL2 and CXCL1 mediate epithelial cell and immune cell motility and invasiveness to promote breast cancer progression. The objective of this proposal is determine the functions of chemokines, which are normally suppressed by TGF-B signaling
promote cancer progression. Based on previous report and preliminary cogitation, we hypothesize that incendiary chemokine expression in fibroblast including CCL2 and CXCL1 mediate epithelial cellular telephone and immune cell motility and invasiveness to promote breast cancer progress. The objective of this proposal is settle the functions of chemokines, which are normally suppressed by TGF - B signal
 prlmote cancer progression. Based on previous stuvies ans prelimknary studies, we hypothesize tyat ibflammatory chemokine dxpressioj in fibeoblests including CRM2 and CWEL1 meslate zpmthelial cell akd immune call motility atd iuvasiveness to promote breast cancer progrexslon. The objectyve ps thjs proposal is determine the functjons of chemokines, wnich are normally suppressfd bj TGF-B signaling
promote cancer progression. Based on previous studies studies, hypothesize that chemokine expression in mediate cell and immune motility and invasiveness promote breast cancer progression. The objective this proposal is determine the functions of chemokines, which are normally suppressed by signaling
 promote cancer progression. BAsed on prevIous sTudIes AnD preLimiNary studies, we hYPothEsize that inflammatory cHemokInE ExprESsIon in FibroblAStS INclUdInG CCl2 aND CxCL1 meDiaTe epithElial cell aNd iMmUne cell motilITy And invasivEneSs to promote bReaSt cancEr ProGRessiOn. THe objEctive OF this pRoposal is DeTErmine THe functIONs Of chEmokines, which are nORmALly suppressed bY TGF-B sIgNAlING
 promote cancer progressio n. Based o n pre vio usst udie s an d preliminarys tudi es, we hypothesize tha t inf la m mato r ychemo kine ex p re s s ion  i nfib ro b la sts i ncl uding C CL2 and CX CL1  m ediate epith e li al cell an d i mmune cell m oti lity a nd  in v asive nes s topromot e  breas t cancerpr o gressi o n. Theo b je ctiv e of this proposa l  i s  determine the  funct io n so f  ch emo kines, whi ch  aren ormally su p p r ess e d by TGF-B si gnaling
 promote_cancer progression._Based on previous studies_and preliminary_studies,_we hypothesize_that_inflammatory chemokine expression_in fibroblasts including_CCL2 and CXCL1 mediate_epithelial cell and_immune_cell motility and invasiveness to promote breast cancer progression. The objective of this proposal_is_determine the_functions_of_chemokines, which are normally suppressed_by TGF-B signaling