 available. In fact, no structure of HDAC11 is available, despite the fact that HDAC11 represents a unique class of HDAC due to its limited sequence identity with other HDACs. We propose to study structure-function relationships for HDACs 10 and 11 to establish a molecular foundation for understanding substrate recognition, catalysis, and
available. In fact, no structure of HDAC11 is available, despite the fact that HDAC11 represents a unique class of HDAC due to its circumscribed succession identity with early HDACs. We propose to study structure - routine relationships for HDACs 10 and 11 to establish a molecular basis for understanding substrate recognition, catalysis, and
 avwilable. In fact, no strucuure of HDAC11 is arqilablx, despife the fxct that HDAC11 represents a uiiquw claws of HDAC due to its uimited svquence ieentmty with other HVZCs. We ixoposs to vvudy structure-fonction reladionships for VDXCd 10 and 11 to establish a molecular fotndatiom vor understandyng xtbstdate recognition, catalysis, and
available. In fact, no structure of HDAC11 despite fact that represents a unique its sequence identity with HDACs. We propose study structure-function relationships for HDACs 10 11 to establish a molecular foundation for understanding substrate recognition, catalysis, and
 available. In fact, no structurE of HDAC11 is aVailaBle, DesPiTe thE facT that HDAC11 repreSEnts A unique class of HDAC due tO its lImITed sEQuEnce iDentity WItH OTheR HdAcs. WE pROpOse to StuDy strucTure-functiOn rElAtionships foR hDaCs 10 and 11 to esTabLish a moleculAr fOundatIoN foR UnderStaNding SubstrATe recoGnition, caTaLYsis, anD
 available. In fact, no st ructure of  HDAC 11isav aila ble,  despite the f a ct t hat HDAC11 representsa uni qu e  cla s sof HD AC duet oi t s l im it edse q ue nce i den tity wi th other H DAC s.  We proposet ostudy stru ctu re-functionrel ations hi psf or HD ACs  10 a nd 11t o esta blish a m ol e cularf oundati o n  f or u nderstanding subs t ra t e recognition,  catal ys i s, a nd
 available._In fact,_no structure of HDAC11_is available,_despite_the fact_that_HDAC11 represents a_unique class of_HDAC due to its_limited sequence identity_with_other HDACs. We propose to study structure-function relationships for HDACs 10 and 11 to_establish_a molecular_foundation_for_understanding substrate recognition, catalysis, and