, studies will be carried out with clinical isolates of currently prevalent M tb strains, and in part with alveolar macrophages from normal human volunteers. Previous studies have identified specific molecular events that result from macrophage exposure to cytokines, and thereby provide a foundation for efforts to examine the interactions between M tb and macrophage that involve cytokines. The overall
, studies will be carried out with clinical isolates of currently prevalent M tb tune, and in character with alveolar macrophages from normal human volunteers. Previous study have identified specific molecular events that leave from macrophage exposure to cytokines, and thereby provide a basis for efforts to examine the interaction between M tb and macrophage that involve cytokines. The overall
, stkdies will be carried ouu with clinical isolates of cudrently orevalent M tb strains, and ii paet wiuk alveolar macrophagds from nlrmal hunan tolunteers. Previous studlzs habc ideutmfied specific kolecular avents that revuut from macrophage exposure to cytokiges, and tjereby provide a fptndafpok for efforts to examine the intsractiois between M tb and macrophage that involge cjtokines. The overapl
, studies will be carried out with of prevalent M strains, and in normal volunteers. Previous studies identified specific molecular that result from macrophage exposure to and thereby provide a foundation for efforts to examine the interactions between M and macrophage that involve cytokines. The overall
, studies will be carried out wiTh clinical IsolaTes Of cUrRentLy prEvalent M tb straINs, anD in part with alveolar macRophaGeS From NOrMal huMan voluNTeERS. PrEvIoUs sTuDIeS have IdeNtified Specific moLecUlAr events that REsUlt from macRopHage exposure To cYtokinEs, And THerebY prOvide A foundATion foR efforts tO eXAmine tHE interaCTIoNs beTween M tb and macropHAgE That involve cytOkines. thE OvERAll
, studies will be carriedout with c linic aliso la tesof c urrently preva l entM tb strains, and in p art w it h  alv e ol ar ma crophag e sf r omno rm alhu m an  volu nte ers. Pr evious stu die shave identif i ed  specificmol ecular event s t hat re su ltf rom m acr ophag e expo s ure to  cytokine s, and th e reby pr o v id e afoundation for ef f or t s to examine t he int er a ct i o nsbet ween M tban d mac r ophaget ha t i nvo l ve cytokines.  The overal l 
, studies_will be_carried out with clinical_isolates of_currently_prevalent M_tb_strains, and in_part with alveolar_macrophages from normal human_volunteers. Previous studies_have_identified specific molecular events that result from macrophage exposure to cytokines, and thereby provide_a_foundation for_efforts_to_examine the interactions between M_tb and macrophage that involve_cytokines. The_overall