 Foam cell formation and associated pro- inflammatory behavior involve transcriptional regulation of many genes, but the specific transcriptional regulatory mechanisms controlling these expression changes in response to various lesion-associated stimuli are not well understood. We will identify transcription factors that regulate foam cell formation using a systems biology approach. Murine macrophages will be stimulated with modified
Foam cell formation and associated pro- inflammatory demeanor imply transcriptional regulation of many genes, but the specific transcriptional regulative mechanisms master these expression changes in reaction to various lesion - associate stimuli are not well understood. We will name transcription factors that regulate foam cell constitution using a systems biology approach. Murine macrophages will be stimulate with modified
 Fowm cell formation and asrociated pro- inyoammatmry begavior ivvolve transcriptional reguletiob of nany genes, but the spezific trajscriptiinal eegulatory mechanisms cohbrollnnj these expresslon changes in response tm xaxious lesion-associated stimuli are njt well ujderstood. We wyll pdqntirj uranscription factors that regulafe foam cell formatipn using a systems biology appgoach. Murine macroohages will be frimulated wigh modified
Foam cell formation and associated pro- inflammatory transcriptional of many but the specific expression in response to lesion-associated stimuli are well understood. We will identify transcription that regulate foam cell formation using a systems biology approach. Murine macrophages will stimulated with modified
 Foam cell formation and assocIated pro- inFlammAtoRy bEhAvioR invOlve transcriptIOnal Regulation of many genes, bUt the SpECifiC TrAnscrIptionaL ReGULatOrY mEchAnISmS contRolLing theSe expressiOn cHaNges in responSE tO various leSioN-associated sTimUli are NoT weLL undeRstOod. We Will idENtify tRanscriptIoN FactorS That regULAtE foaM cell formation usiNG a SYstems biology aPproacH. MURiNE MacRopHages will bE sTimulATed with MOdIFIEd
 Foam cell formation and a ssociatedpro-inf lam ma tory  beh avior involvet rans criptional regulationof ma ny gene s ,but t he spec i fi c tra ns cr ipt io n al  regu lat ory mec hanisms co ntr ol ling these e x pr ession cha nge s in respons e t o vari ou s l e sion- ass ociat ed sti m uli ar e not wel lu nderst o od. Wew i ll  ide ntify transcripti o nf actors that re gulate  f o am c ell  fo rmation us in g a s y stems b i ol o g y  ap p roach. Murine  macrophage s  wi ll best imu l ated w ith m od i fie d
 Foam_cell formation_and associated pro- inflammatory_behavior involve_transcriptional_regulation of_many_genes, but the_specific transcriptional regulatory_mechanisms controlling these expression_changes in response_to_various lesion-associated stimuli are not well understood. We will identify transcription factors that regulate_foam_cell formation_using_a_systems biology approach. Murine macrophages_will be stimulated with modified