4) develop efficient path methods to study chemical mechanisms and conformational transitions in ribozymes. In this way we hope to greatly extend the predictive capability and range of application of state of the art theoretical methods to RNA catalysis. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to use quantum mechanical and molecular
4) develop efficient path methods to analyze chemical mechanism and conformational transitions in ribozymes. In this way we hope to greatly extend the predictive capability and image of application of state of the artwork theoretical methods to RNA catalysis. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to practice quantum mechanical and molecular
4) degelop efficient path metmods to study chgmucal mxchanisjs and cunformational transitions in rubozynes. In this way we hopd to greanly extene tht predictive capaujlity akb ranfc of cp'lication of stste of the art theoreticdl mzthods to RNA catalysis. PUBLIC HEALTR RELEVSNFE: The goal of thix prolosal is to use quantum mechanical and monecular
4) develop efficient path methods to study and transitions in In this way the capability and range application of state the art theoretical methods to RNA PUBLIC HEALTH RELEVANCE: The goal of this proposal is to use quantum mechanical molecular
4) develop efficient path methoDs to study cHemicAl mEchAnIsms And cOnformational tRAnsiTions in ribozymes. In this Way we HoPE to gREaTly exTend the PReDICtiVe CaPabIlITy And raNge Of appliCation of stAte Of The art theoreTIcAl methods tO RNa catalysis. PUbLIc HEALTh ReLEvaNCE: THe gOal of This prOPosal iS to use quaNtUM mechaNIcal and MOLeCulaR
4) develop efficient pathmethods to  stud y c hem ic al m echa nisms and conf o rmat ional transitions in r ibozy me s . In th is wa y we ho p et o  gr ea tl y e xt e nd  thepre dictive  capabilit y a nd  range of ap p li cation ofsta te of the ar t t heoret ic alm ethod s t o RNA  catal y sis. P UBLIC HEA LT H  RELEV A NCE: Th e go al o f this proposal i s  t o  use quantum m echani ca l  a n d  mo lec ular
4) develop_efficient path_methods to study chemical_mechanisms and_conformational_transitions in_ribozymes._In this way_we hope to_greatly extend the predictive_capability and range_of_application of state of the art theoretical methods to RNA catalysis. PUBLIC HEALTH RELEVANCE:_The_goal of_this_proposal_is to use quantum mechanical_and molecular