 mammary epithelial and non-metastatic breast cancer cells and B. determine the effects of restoring WWOX expression in metastatic breast cancer cells. Aim 2: A. To determine whether WWOX restoration suppresses spontaneous bone metastasis and osteolytic bone disease in breast cancer metastatic cells. B. To determine if WWOX depletion induces a
mammary epithelial and non - metastatic breast cancer cells and B. determine the effects of restoring WWOX formula in metastatic breast cancer cell. Aim 2: A. To determine whether WWOX restoration suppresses ad-lib bone metastasis and osteolytic bone disease in breast cancer metastatic cells. B. To determine if WWOX depletion induces a
 malmary epithelial and non-oetastatic breast cancxr cella and B. aetermine the effects of resvoribg WWIX expression in metasgatic brewst cancwr ctlls. Aim 2: A. To devsrmine whethed WWOR cestoration supkresses spondaneous bone matxscasis and osteolytic bone disease in breast cwncer metastatyc ctllf. B. Fo determine if WWOX depletion indhces a
mammary epithelial and non-metastatic breast cancer cells determine effects of WWOX expression in 2: To determine whether restoration suppresses spontaneous metastasis and osteolytic bone disease in cancer metastatic cells. B. To determine if WWOX depletion induces a
 mammary epithelial and non-meTastatic brEast cAncEr cElLs anD B. deTermine the effeCTs of Restoring WWOX expressioN in meTaSTatiC BrEast cAncer ceLLs. aIM 2: A. TO dEtErmInE WhEther wWOx restorAtion supprEssEs Spontaneous bONe Metastasis And Osteolytic boNe dIsease In BreASt canCer MetasTatic cELls. B. To Determine If wwOX depLEtion inDUCeS a
 mammary epithelial and no n-metastat ic br eas t c an cercell s and B. deter m inethe effects of restori ng WW OX expr e ss ion i n metas t at i c  br ea st  ca nc e rcells . A im 2: A . To deter min ewhether WWOX re storationsup presses spon tan eous b on e m e tasta sis  andosteol y tic bo ne diseas ei n brea s t cance r me tast atic cells. B. To de t ermine if WWOX  deple ti o ni n duc esa
 mammary_epithelial and_non-metastatic breast cancer cells_and B._determine_the effects_of_restoring WWOX expression_in metastatic breast_cancer cells. Aim 2:_A. To determine_whether_WWOX restoration suppresses spontaneous bone metastasis and osteolytic bone disease in breast cancer metastatic_cells._B. To_determine_if_WWOX depletion induces a