 the disease. Therefore, there is a dire need for the development of novel strategies by which pancreatic tumor progression could be prevented. The constitutive activation of EGFR and Akt signaling, commonly seen in PC, is known to activate NF-:B, which transcriptionally regulates many genes contributing to aggressive tumor growth, angiogenesis and invasion,
the disease. Therefore, there is a dire need for the growth of fresh strategies by which pancreatic tumor progression could be prevent. The constituent activation of EGFR and Akt signaling, commonly seen in PC, is know to activate NF-:B, which transcriptionally regulates many gene contribute to aggressive tumor growth, angiogenesis and invasion,
 thf disease. Therefore, thert is a dire need yir the develkpment ow novel strategies by which 'anceeatix tumor progression cojld be prvvented. Tye cibstitutive activatljn or EGFX end Akt signalikg, commonly seen in PC, is kvocn to activate NF-:B, which transcriptijnally tehulates many ggnes bogtrigltlng to aggressive tumor growth, ahgiogentsis and invasion,
the disease. Therefore, there is a dire the of novel by which pancreatic The activation of EGFR Akt signaling, commonly in PC, is known to activate which transcriptionally regulates many genes contributing to aggressive tumor growth, angiogenesis and invasion,
 the disease. Therefore, there iS a dire need For thE deVelOpMent Of noVel strategies bY WhicH pancreatic tumor progreSsion CoULd be PReVenteD. The conSTiTUTivE aCtIvaTiON oF EGFR And akt signAling, commoNly SeEn in PC, is knowN To Activate NF-:b, whIch transcripTioNally rEgUlaTEs manY geNes coNtribuTIng to aGgressive TuMOr growTH, angiogENEsIs anD invasion,
 the disease. Therefore, t here is adirenee d f or  the  dev elopment of no v el s trategies by which pan creat ic tumo r  p rogre ssion c o ul d bepr ev ent ed .  T he co nst itutive  activatio n o fEGFR and Akt si gnaling, c omm only seen in  PC , is k no wnt o act iva te NF -:B, w h ich tr anscripti on a lly re g ulatesm a ny  gen es contributing t o  a g gressive tumor  growt h, an g i oge nes is and inv as ion,
 the_disease. Therefore,_there is a dire_need for_the_development of_novel_strategies by which_pancreatic tumor progression_could be prevented. The_constitutive activation of_EGFR_and Akt signaling, commonly seen in PC, is known to activate NF-:B, which transcriptionally_regulates_many genes_contributing_to_aggressive tumor growth, angiogenesis and_invasion,