 the initiation and progression of the disease. This proposal will address the function of the transcription factor, Pax-2, in the development of normal and cystic renal epithelium. Pax-2 is required and sufficient for the conversion of the kidney mesenchyme to an epithelial phenotype by acting as a differentiation and proliferation stimulus.
the initiation and progression of the disease. This proposal will address the affair of the arrangement factor, Pax-2, in the development of normal and cystic renal epithelium. Pax-2 is ask and sufficient for the conversion of the kidney mesenchyme to an epithelial phenotype by acting as a differentiation and proliferation stimulation.
 thf initiation and progresrion of the disgawe. Thiv propksal wilu address the function of thx trqnscruption factor, Pax-2, in tfe develoiment of bormel and cystic reizl epitmzlium. Iax-2 iv required and xufficient for the convesskou of the kidney mesenchyme to an epiehelial pjenotype by acjing sf a spfnerentiation and proliferation sfimulus.
the initiation and progression of the disease. will the function the transcription factor, normal cystic renal epithelium. is required and for the conversion of the kidney to an epithelial phenotype by acting as a differentiation and proliferation stimulus.
 the initiation and progressiOn of the disEase. THis ProPoSal wIll aDdress the functIOn of The transcription factor, pax-2, in ThE DeveLOpMent oF normal ANd CYStiC rEnAl ePiTHeLium. PAx-2 iS requirEd and suffiCieNt For the converSIoN of the kidnEy mEsenchyme to aN epItheliAl PheNOtype By aCting As a difFErentiAtion and pRoLIferatIOn stimuLUS.
 the initiation and progre ssion of t he di sea se.  T hisprop osal will addr e ss t he function of the tra nscri pt i on f a ct or, P ax-2, i n  t h e  de ve lo pme nt of  norm aland cys tic renalepi th elium. Pax-2 is  requiredand  sufficientfor  the c on ver s ion o f t he ki dney m e senchy me to anep i thelia l  phenot y p eby a cting as a differ e nt i ation and prol iferat io n  s t i mul us. 
 the_initiation and_progression of the disease._This proposal_will_address the_function_of the transcription_factor, Pax-2, in_the development of normal_and cystic renal_epithelium._Pax-2 is required and sufficient for the conversion of the kidney mesenchyme to an_epithelial_phenotype by_acting_as_a differentiation and proliferation stimulus.