 aim #2, we will determine if the sex chromosome effect in the CNS during EAE is due to the dose of X or Y genes. Finally in aim #3, we will use mice which differ in gonadal type, female vs. male, while having the same sex chromosome complement (XX vs. XX S
aim # 2, we will determine if the sex chromosome effect in the central nervous system during EAE is ascribable to the acid of X or Y genes. ultimately in bearing # 3, we will use mice which disagree in gonadal type, female vs. male, while having the same sexual activity chromosome complement (XX vs. XX S
 ail #2, we will determine if uhe sex chromosomg wffect in ths CNS dufing EAE is due to the dose lf X or Y genes. Finally in aio #3, we wilp use mixe wiich differ in gonadal tn'e, fejwle rs. male, while haying the sake sex chromosmmd eomplement (XX vs. XX S
aim #2, we will determine if the effect the CNS EAE is due or genes. Finally in #3, we will mice which differ in gonadal type, vs. male, while having the same sex chromosome complement (XX vs. XX S
 aim #2, we will determine if the seX chromosomE effeCt iN thE CnS duRing eAE is due to the dOSe of x or Y genes. Finally in aim #3, wE will UsE Mice WHiCh difFer in goNAdAL TypE, fEmAle Vs. MAlE, whilE haVing the Same sex chrOmoSoMe complement (xx vS. XX S
 aim #2, we will determine  if the se x chr omo som eeffe ct i n the CNS duri n g EA E is due to the dose o f X o rY  gen e s.  Fina lly ina im # 3,we  w ill  u s emicewhi ch diff er in gona dal  t ype, femalev s.  male, whi lehaving the s ame  sex c hr omo s ome c omp lemen t (XXv s. XXS
 aim_#2, we_will determine if the_sex chromosome_effect_in the_CNS_during EAE is_due to the_dose of X or_Y genes. Finally_in_aim #3, we will use mice which differ in gonadal type, female vs. male,_while_having the_same_sex_chromosome complement (XX vs. XX_S