 the nasopharynx. Experience with conjugate vaccines has demonstrated that interrupting colonization results in herd immunity that amplifies prevention of disease in the population. To better understand the biology of colonization, during the prior funding period, we utilized a murine model to characterize bacterial and host factors that allow for pneumococcal persistence and its eventual clearance
the nasopharynx. Experience with conjugate vaccines has demonstrated that interrupting colonization results in ruck unsusceptibility that amplifies prevention of disease in the population. To better sympathize the biology of colonization, during the anterior funding period, we utilize a murine mannequin to characterize bacterial and horde factors that allow for pneumococcal perseverance and its eventual clearance
 thf nasopharynx. Experience with conjugate vaccinxs has semonstrxted that interrupting colonmzatuon rtfults in herd immuvity that amplifiws pcevention of disxzse in bke polmlatimi. To better undgrstand the tiology of colmnkzction, during the prior funding perioq, we utollzed a murine iodek to dharacterize bacterial and host fadtors tiat allow for pmeumococcal persistence anf itd eventual clearanfe
the nasopharynx. Experience with conjugate vaccines has interrupting results in immunity that amplifies population. better understand the of colonization, during prior funding period, we utilized a model to characterize bacterial and host factors that allow for pneumococcal persistence and eventual clearance
 the nasopharynx. Experience wIth conjugaTe vacCinEs hAs DemoNstrAted that interrUPtinG colonization results in Herd iMmUNity THaT amplIfies prEVeNTIon Of DiSeaSe IN tHe popUlaTion. To bEtter underStaNd The biology of COlOnization, dUriNg the prior fuNdiNg periOd, We uTIlizeD a mUrine Model tO CharacTerize bacTeRIal and HOst factORS tHat aLlow for pneumococcAL pERsistence and itS eventUaL ClEARanCe
 the nasopharynx. Experien ce with co njuga tevac ci neshasdemonstrated t h at i nterrupting colonizati on re su l ts i n  h erd i mmunity th a t  am pl if ies  p r ev entio n o f disea se in thepop ul ation. To be t te r understa ndthe biologyofcoloni za tio n , dur ing  thepriorf unding  period,we utiliz e d a mur i n emode l to characterize ba c terial and hos t fact or s  t h a t a llo w for pneu mo cocca l  persis t en c e and its eventualclearance
 the_nasopharynx. Experience_with conjugate vaccines has_demonstrated that_interrupting_colonization results_in_herd immunity that_amplifies prevention of_disease in the population._To better understand_the_biology of colonization, during the prior funding period, we utilized a murine model to_characterize_bacterial and_host_factors_that allow for pneumococcal persistence_and its eventual clearance