 and presenilin comprise one of just three superfamilies of intramembrane proteases. The details of regulated intramembrane proteolysis, from cell biological signaling to active site chemistry, are of both fundamental biochemical importance and potential therapeutic application. How substrates are presented and hydrolyzed within the confines of the hydrophobic space of the
and presenilin comprise one of just three superfamilies of intramembrane proteases. The detail of determine intramembrane proteolysis, from cell biological signaling to active site chemistry, are of both cardinal biochemical importance and potential therapeutic application. How substrate are presented and hydrolyzed within the confines of the hydrophobic outer space of the
 anf presenilin comprise ont of just three sopwrfaminies or intramdmbrane proteases. The detaild if retulated intramembrane oroteolysps, from cwll uiological signaling to active dite rhemistry, are on both funddmental biochekizap importance and potential therapeueic appkifation. How subftraues are irtsented and hydrolyzed within the confints of the hydrophonic space of the
and presenilin comprise one of just three intramembrane The details regulated intramembrane proteolysis, active chemistry, are of fundamental biochemical importance potential therapeutic application. How substrates are and hydrolyzed within the confines of the hydrophobic space of the
 and presenilin comprise one oF just three SuperFamIliEs Of inTramEmbrane proteasES. The Details of regulated intrAmembRaNE proTEoLysis, From celL BiOLOgiCaL sIgnAlINg To actIve Site cheMistry, are oF boTh Fundamental bIOcHemical impOrtAnce and potenTiaL theraPeUtiC AppliCatIon. HoW substRAtes arE presenteD aND hydroLYzed witHIN tHe coNfines of the hydropHObIC space of the
 and presenilin comprise o ne of just  thre e s upe rf amil iesof intramembra n e pr oteases. The details o f reg ul a tedi nt ramem brane p r ot e o lys is ,fro mc el l bio log ical si gnaling to  ac ti ve site chem i st ry, are of  bo th fundament albioche mi cal impor tan ce an d pote n tial t herapeuti ca pplica t ion. Ho w su bstr ates are presente d  a n d hydrolyzed w ithinth e  c o n fin esof the hyd ro phobi c  spaceo ft h e 
 and_presenilin comprise_one of just three_superfamilies of_intramembrane_proteases. The_details_of regulated intramembrane_proteolysis, from cell_biological signaling to active_site chemistry, are_of_both fundamental biochemical importance and potential therapeutic application. How substrates are presented and hydrolyzed_within_the confines_of_the_hydrophobic space of the