 mutant cells to ionizing radiation. In addition we studied the mechanism of Doxorubicin resistance in p53 mutant breast cancer cells. Data already obtained show that standard bicycle exercise evokes a greater steady-state O2 consumption and a larger O2 debt during pregnancy than postpartum. Continuing studies will extend observations to the
mutant cells to ionizing radiation. In addition we study the mechanism of Doxorubicin underground in p53 mutant breast cancer cells. Data already obtained appearance that standard bicycle exercise evokes a bang-up firm - state O2 consumption and a larger O2 debt during pregnancy than postpartum. Continuing report will extend observations to the
 muhant cells to ionizing rxdiation. In addnrion wx studisd the mdchanism of Doxorubicin residtqnce un p53 mutant breast canzer cells. Data aleeadb obtained show vgat stakbard glcyclz xxercise evokes a greater steady-state O2 cundumption and a larger O2 debt during pregnamcj than postparjum. Cpgtinhpnn studies will extend observatiohs to tie
mutant cells to ionizing radiation. In addition the of Doxorubicin in p53 mutant obtained that standard bicycle evokes a greater O2 consumption and a larger O2 during pregnancy than postpartum. Continuing studies will extend observations to the
 mutant cells to ionizing radiAtion. In addItion We sTudIeD the MechAnism of DoxorubICin rEsistance in p53 mutant breaSt canCeR CellS. daTa alrEady obtAInED ShoW tHaT stAnDArD bicyCle ExercisE evokes a grEatEr Steady-state O2 COnSumption anD a lArger O2 debt duRinG pregnAnCy tHAn posTpaRtum. COntinuINg studIes will exTeND obserVAtions tO THe
 mutant cells to ionizingradiation.  In a ddi tio nwe s tudi ed the mechani s m of  Doxorubicin resistanc e inp5 3  mut a nt  brea st canc e rc e lls .Da taal r ea dy ob tai ned sho w that sta nda rd  bicycle exe r ci se evokesa g reater stead y-s tate O 2con s umpti onand a  large r  O2 de bt during  p r egnanc y  than p o s tp artu m. Continuing stu d ie s  will extend o bserva ti o ns t o t he
 mutant_cells to_ionizing radiation. In addition_we studied_the_mechanism of_Doxorubicin_resistance in p53_mutant breast cancer_cells. Data already obtained_show that standard_bicycle_exercise evokes a greater steady-state O2 consumption and a larger O2 debt during pregnancy_than_postpartum. Continuing_studies_will_extend observations to the