 less is known regarding the role of cPLA2 in the tumor microenvironment. During the past funding period, we showed that cPLA2 knockout (KO) mice are protected against chemicallyinduced lung tumorigenesis. However, these studies do not discriminate between the action of cPLA2 in the tumor cells versus the surrounding stromal. To
less is known regarding the role of cPLA2 in the tumor microenvironment. During the past funding time period, we usher that cPLA2 knockout (KO) mice are protected against chemicallyinduced lung tumorigenesis. However, these study do not discriminate between the action of cPLA2 in the tumor cells versus the wall stromal. To
 leds is known regarding tht role of cPLA2 in the tukor midroenvirunment. During the past fundiig pwriod, we showed that cPLA2 kvockout (KL) mice aee pcotected against chemicallyindhged lbnj tumorigenesis. However, tvese studies dm voc discriminate between the action of cPLA2 im hhe tumor cellf vegsts tgv wurrounding stromal. To
less is known regarding the role of the microenvironment. During past funding period, (KO) are protected against lung tumorigenesis. However, studies do not discriminate between the of cPLA2 in the tumor cells versus the surrounding stromal. To
 less is known regarding the roLe of cPLA2 in The tuMor MicRoEnviRonmEnt. During the paST funDing period, we showed that CPLA2 kNoCKout (ko) mIce arE protecTEd AGAinSt ChEmiCaLLyInducEd lUng tumoRigenesis. HOweVeR, these studieS Do Not discrimInaTe between the ActIon of cpLa2 in THe tumOr cElls vErsus tHE surroUnding strOmAL. To
 less is known regarding t he role of  cPLA 2 i n t he  tum or m icroenvironmen t . Du ring the past fundingperio d, we s h ow ed th at cPLA 2  k n o cko ut  ( KO)  m i ce  arepro tectedagainst ch emi ca llyinduced l u ng  tumorigen esi s. However,the se stu di esd o not  di scrim inateb etween  the acti on of cPL A 2 in th e tu morcells versus thes ur r ounding stroma l. To
 less_is known_regarding the role of_cPLA2 in_the_tumor microenvironment._During_the past funding_period, we showed_that cPLA2 knockout (KO)_mice are protected_against_chemicallyinduced lung tumorigenesis. However, these studies do not discriminate between the action of cPLA2_in_the tumor_cells_versus_the surrounding stromal. To