) as well as how the cells naturally destroy disordered proteins that fail to traffic out of the ER. Searching databases we have found that many secreted, acidic proteins encode similar peptide motifs that we propose are used to interact with a conserved ER cargo receptor. This proposed cargo receptor then traffics negatively charged proteins (as well as
) as well as how the cells naturally destroy disordered protein that fail to traffic out of the ER. research databases we have found that many secrete, acidic protein encode similar peptide motifs that we propose are practice to interact with a conserved ER cargo receptor. This proposed cargo sense organ then traffic negatively charged protein (as well as
) as well as how the cells nxturally destroi eisordxred prkteins tfat fail to traffic out of tie EE. Seaeching databases we haxe found nhat many secceted, acidic provsins engjde almilax 'eptide motifs jhat we propmse are used tm knceract with a conserved ER cargo recqptor. Tnid proposed cardo rtce[tor nhtn traffics negatively charged prkteins (es well as
) as well as how the cells disordered that fail traffic out of have that many secreted, proteins encode similar motifs that we propose are used interact with a conserved ER cargo receptor. This proposed cargo receptor then traffics charged proteins (as well as
) as well as how the cells naturaLly destroy DisorDerEd pRoTeinS thaT fail to traffic OUt of The ER. Searching databaseS we haVe FOund THaT many SecreteD, AcIDIc pRoTeIns EnCOdE simiLar Peptide Motifs that We pRoPose are used tO InTeract with A coNserved ER carGo rEceptoR. THis PRoposEd cArgo rEceptoR Then trAffics negAtIVely chARged proTEInS (as wEll as
) as well as how the cells  naturally  dest roy  di so rder ed p roteins that f a il t o traffic out of the E R. Se ar c hing da tabas es we h a ve f oun dth atma n ysecre ted , acidi c proteins  en co de similar p e pt ide motifs  th at we propos e a re use dtoi ntera ctwitha cons e rved E R cargo r ec e ptor.T his pro p o se d ca rgo receptor then tr a ffics negative ly cha rg e dp r ote ins  (as wellas 
) as_well as_how the cells naturally_destroy disordered_proteins_that fail_to_traffic out of_the ER. Searching_databases we have found_that many secreted,_acidic_proteins encode similar peptide motifs that we propose are used to interact with a_conserved_ER cargo_receptor._This_proposed cargo receptor then traffics_negatively charged proteins (as well_as