 high-level, long-term expression of a number of therapeutic proteins without eliciting a clinically significant immune reaction. The investigators have recently demonstrated high-efficacy gene transfer of GAA into embryonic tissues, cultured adult and neonatal rat cardiomyocytes, as well as, adult rat heart, and murine skeletal muscle in vivo using this
high - level, long - term formula of a numeral of therapeutic proteins without eliciting a clinically meaning immune reaction. The investigators have recently demonstrated eminent - efficacy gene transfer of GAA into embryonic tissues, civilized adult and neonatal informer cardiomyocytes, as well as, adult informer heart, and murine skeletal muscleman in vivo using this
 hihh-level, long-term expresslon of a number of therepeutic proteinr without eliciting a clinicelly signuficant immune reactiov. The invvstigatorw hate recently demoiatrated high-ernicacv jene transfer on GAA into ambryonic tissger, eultured adult and neonatal rat cardyomyocyyed, as well as, aqult wat gvavt, and murine skeletal muscle in vivo uving this
high-level, long-term expression of a number of without a clinically immune reaction. The gene of GAA into tissues, cultured adult neonatal rat cardiomyocytes, as well as, rat heart, and murine skeletal muscle in vivo using this
 high-level, long-term expressiOn of a numbeR of thEraPeuTiC proTeinS without elicitINg a cLinically significant imMune rEaCTion. tHe InvesTigatorS HaVE RecEnTlY deMoNStRated HigH-efficaCy gene tranSfeR oF GAA into embrYOnIc tissues, cUltUred adult and NeoNatal rAt CarDIomyoCytEs, as wEll as, aDUlt rat Heart, and mUrINe skelETal muscLE In Vivo Using this
 high-level, long-term exp ression of  a nu mbe r o fther apeu tic proteins w i thou t eliciting a clinical ly si gn i fica n timmun e react i on . The  i nv est ig a to rs ha verecentl y demonstr ate dhigh-efficac y  g ene transf erof GAA intoemb ryonic  t iss u es, c ult uredadulta nd neo natal rat  c a rdiomy o cytes,a s  w ellas, adult rat hea r t, and murine ske letalmu s cl e inviv o using th is 
 high-level,_long-term expression_of a number of_therapeutic proteins_without_eliciting a_clinically_significant immune reaction._The investigators have_recently demonstrated high-efficacy gene_transfer of GAA_into_embryonic tissues, cultured adult and neonatal rat cardiomyocytes, as well as, adult rat heart,_and_murine skeletal_muscle_in_vivo using this