 mechanism(s) of mutant SOD1-mediated toxicity and to define a potential role for the mitochondrial mutant SOD1/Bcl-2 complex in ALS pathogenesis. The specific aims are: 1) (A) To determine whether WT SOD1 pro-survival activity depends on its binding to Bcl-2, and
mechanism(s) of mutant SOD1 - mediated toxicity and to define a potential function for the mitochondrial mutant SOD1 / Bcl-2 building complex in ALS pathogenesis. The specific aims are: 1) (A) To settle whether WT SOD1 pro - survival bodily process depends on its binding to Bcl-2, and
 mefhanism(s) of mutant SOD1-meaiated toxicity and to defins a potevtial role for the mitochondcial mutabt SOD1/Bcl-2 complex in AUS pathogvnesis. Thw sptcific aims are: 1) (E) To detcxmine ahetkec WT SOD1 pro-suryival activhty depends on igs binding to Bcl-2, and
mechanism(s) of mutant SOD1-mediated toxicity and to potential for the mutant SOD1/Bcl-2 complex aims 1) (A) To whether WT SOD1 activity depends on its binding to and
 mechanism(s) of mutant SOD1-mediAted toxiciTy and To dEfiNe A potEntiAl role for the miTOchoNdrial mutant SOD1/Bcl-2 compLex in aLs PathOGeNesis. the specIFiC AIms ArE: 1) (A) to dEtERmIne whEthEr WT SOD1 Pro-survivaL acTiVity depends oN ItS binding to bcl-2, And
 mechanism(s) of mutant SO D1-mediate d tox ici tyan d to  def ine a potentia l  rol e for the mitochondria l mut an t  SOD 1 /B cl-2complex in A LSpa th oge ne s is . The  sp ecificaims are:1)(A ) To determi n ewhether WT  SO D1 pro-survi val  activ it y d e pends  on  itsbindin g  to Bc l-2, and
 mechanism(s)_of mutant_SOD1-mediated toxicity and to_define a_potential_role for_the_mitochondrial mutant SOD1/Bcl-2_complex in ALS_pathogenesis. The specific aims_are: 1) (A)_To_determine whether WT SOD1 pro-survival activity depends on its binding to Bcl-2, and