 for the permeability response for these and other permeabilizing factors. By screening a commercially available library, we have already identified a class of inhibitors for this target and in this grant we propose to combine medicinal chemists, structural biologists and cellular and molecular physiologists to develop compounds that control retinal blood vessel permeability in multiple models
for the permeability response for these and other permeabilizing factors. By screening a commercially available library, we have already identify a course of inhibitors for this target and in this concession we propose to aggregate medicinal pharmacist, morphologic biologists and cellular and molecular physiologist to originate compounds that master retinal blood vessel permeability in multiple models
 fog the permeability respokse for these anb other permezbilizine factors. By screening a comleecialoy available library, wd have algeady idebtifmed a class of iigibitors for fmis tcrjet and in this grant we [ropose to comtive medicinal chemists, structural bioljgists snf cellular and moltcujar lhysiologists to develop compounds that cmntrol retinak blood vessel permeabilitj in multiple models
for the permeability response for these and factors. screening a available library, we of for this target in this grant propose to combine medicinal chemists, structural and cellular and molecular physiologists to develop compounds that control retinal blood vessel in multiple models
 for the permeability responsE for these aNd othEr pErmEaBiliZing Factors. By screeNIng a Commercially available lIbrarY, wE Have ALrEady iDentifiED a CLAss Of InHibItORs For thIs tArget anD in this graNt wE pRopose to combINe Medicinal cHemIsts, structurAl bIologiStS anD CelluLar And moLeculaR PhysioLogists to DeVElop coMPounds tHAT cOntrOl retinal blood vesSEl PErmeability in mUltiplE mODeLS
 for the permeability resp onse for t heseand  ot he r pe rmea bilizing facto r s. B y screening a commerci allyav a ilab l elibra ry, weh av e alr ea dy  id en t if ied a  cl ass ofinhibitors  fo rthis targeta nd  in this g ran t we propose  to  combi ne  me d icina l c hemis ts, st r uctura l biologi st s  and c e llulara n dmole cular physiologis t st o develop comp oundsth a tc o ntr olretinal bl oo d ves s el perm e ab i l i tyi n multiple mo dels
 for_the permeability_response for these and_other permeabilizing_factors._By screening_a_commercially available library,_we have already_identified a class of_inhibitors for this_target_and in this grant we propose to combine medicinal chemists, structural biologists and cellular_and_molecular physiologists_to_develop_compounds that control retinal blood_vessel permeability in multiple models