 modify these distinct substrates. Our long-term objectives are to determine the mechanism of protein specific polysialylation, what factors regulate the polymerization of polySia chains on specific substrates, and how polySia modulates the functions of the proteins it modifies. In this proposal we will test the hypothesis that the polySTs
modify these distinct substrates. Our long - condition aim are to determine the mechanism of protein specific polysialylation, what factors regulate the polymerization of polySia chain on specific substrates, and how polySia modulates the function of the protein it modifies. In this proposal we will test the hypothesis that the polySTs
 mofify these distinct subsurates. Our long-tetm objecvives ade to degermine the mechanism of provein specufic polysialylation, wfat factogs regulare tie polymerizatioi of polnFia dmains in specific sunstrates, ang how polySia koaupates the functions of the proteins it modofles. In this prjpossj we will test the hypothesis that the polySTv
modify these distinct substrates. Our long-term objectives determine mechanism of specific polysialylation, what polySia on specific substrates, how polySia modulates functions of the proteins it modifies. this proposal we will test the hypothesis that the polySTs
 modify these distinct substrAtes. Our lonG-term ObjEctIvEs arE to dEtermine the mecHAnisM of protein specific polySialyLaTIon, wHAt FactoRs regulATe THE poLyMeRizAtIOn Of polYSiA chains On specific SubStRates, and how pOLysia modulatEs tHe functions oF thE proteInS it MOdifiEs. IN this ProposAL we wilL test the hYpOThesis THat the pOLYSts
 modify these distinct sub strates. O ur lo ng- ter mobje ctiv es are to dete r mine  the mechanism of prot ein s pe c ific po lysia lylatio n ,w h atfa ct ors  r e gu latethe  polyme rization o f p ol ySia chainso nspecific s ubs trates, andhow  polyS ia  mo d ulate s t he fu nction s  of th e protein si t modi f ies. In t hi s pr oposal we will te s tt he hypothesisthat t he po l y STs 
 modify_these distinct_substrates. Our long-term objectives_are to_determine_the mechanism_of_protein specific polysialylation,_what factors regulate_the polymerization of polySia_chains on specific_substrates,_and how polySia modulates the functions of the proteins it modifies. In this proposal_we_will test_the_hypothesis_that the polySTs