 We have shown that NSCLC cell lines expressing oncogenic K-Ras have elevated levels of PGE2 production, mediated through induction of cPLA2 and COX-2. Blocking this pathway inhibits transformed growth in vitro and in xeno graft models, supporting a role for cPLA2 in lung cancer progression. However,
We have shown that NSCLC cell lines expressing oncogenic thousand - Ras take elevated levels of PGE2 production, mediate through induction of cPLA2 and COX-2. Blocking this nerve pathway inhibits transformed growth in vitro and in xeno bribery model, supporting a role for cPLA2 in lung cancer progression. However,
 We have shown that NSCLC ctll lines expressnbg oncmgenic K-Ras haxe elevated levels of PGE2 prldyctiob, mediated through indjction of cPLA2 ane COE-2. Blocking this 'zthway luhibifd trcnwformed growth in vitro dnd in xeno grdfg lodels, supporting a role for cPLA2 ig lung vajcer progressijn. Hpreved,
We have shown that NSCLC cell lines K-Ras elevated levels PGE2 production, mediated COX-2. this pathway inhibits growth in vitro in xeno graft models, supporting a for cPLA2 in lung cancer progression. However,
 We have shown that NSCLC cell lInes expresSing oNcoGenIc k-Ras Have Elevated levels OF PGE2 Production, mediated throUgh inDuCTion OF cpLA2 anD COX-2. BloCKiNG ThiS pAtHwaY iNHiBits tRanSformed Growth in viTro AnD in xeno graft MOdEls, supportIng A role for cPLA2 In lUng canCeR prOGressIon. howevEr,
 We have shown that NSCLCcell lines  expr ess ing  o ncog enic  K-Ras have el e vate d levels of PGE2 produ ction ,m edia t ed  thro ugh ind u ct i o n o fcP LA2  a n dCOX-2 . B locking  this path way  i nhibits tran s fo rmed growt h i n vitro andinxeno g ra ftm odels , s uppor ting a role f or cPLA2in lung c a ncer pr o g re ssio n. However,
 We_have shown_that NSCLC cell lines_expressing oncogenic_K-Ras_have elevated_levels_of PGE2 production,_mediated through induction_of cPLA2 and COX-2._Blocking this pathway_inhibits_transformed growth in vitro and in xeno graft models, supporting a role for cPLA2_in_lung cancer_progression._However,