-4 activation, and T-bet, GATA-3 and c-maf mRNA expression, respectively. Whether infected dendritic cells can induce such alterations in CD4+ T cells will also be determined. Taken together these studies represent the first to define mechanisms whereby an intracellular bacterial pathogen can adversely affect the early development of
-4 activation, and T - bet, GATA-3 and c - maf mRNA formula, respectively. Whether septic dendritic cells can induce such alterations in CD4 + T cell will besides be determined. Taken together these study represent the first to specify mechanisms whereby an intracellular bacterial pathogen can adversely affect the early exploitation of
-4 achivation, and T-bet, GATA-3 akd c-maf mRNA exptewsion, cespectjvely. Whdther infected dendritic celps can unduce such alterationr in CD4+ T cells wull elso be determinxs. Taken togetgcr thzsx studies reprexent the fhrst to define mdckanisms whereby an intracellular baceerial lahhogen can advgrselj wffedn uhe early development of
-4 activation, and T-bet, GATA-3 and c-maf respectively. infected dendritic can induce such will be determined. Taken these studies represent first to define mechanisms whereby an bacterial pathogen can adversely affect the early development of
-4 activation, and T-bet, GATA-3 and c-Maf mRNA expRessiOn, rEspEcTiveLy. WhEther infected dENdriTic cells can induce such aLteraTiONs in cd4+ T Cells Will alsO Be DETerMiNeD. TaKeN ToGetheR thEse studIes represeNt tHe First to definE MeChanisms whEreBy an intracelLulAr bactErIal PAthogEn cAn advErsely AFfect tHe early deVeLOpment OF
-4 activation, and T-bet,GATA-3 and  c-ma f m RNA  e xpre ssio n, respectivel y . Wh ether infected dendrit ic ce ll s  can in ducesuch al t er a t ion sin  CD 4+ Tcells  wi ll also  be determ ine d.  Taken toget h er  these stu die s representthe  first  t o d e finemec hanis ms whe r eby an  intracel lu l ar bac t erial p a t ho gencan adversely aff e ct the early deve lopmen to f
-4 activation,_and T-bet,_GATA-3 and c-maf mRNA_expression, respectively._Whether_infected dendritic_cells_can induce such_alterations in CD4+_T cells will also_be determined. Taken_together_these studies represent the first to define mechanisms whereby an intracellular bacterial pathogen can_adversely_affect the_early_development_of