 PROJECT SUMMARY The molecular mechanisms that underpin the development of insulin resistance with age remain poorly defined, yet a better understanding of this process is critical, given the fact that obesity, metabolic disease and diabetes have reached epidemic status in the US. We discovered that alternative splicing of the insulin receptor in humans leads to truncated isoforms that
PROJECT SUMMARY The molecular mechanisms that underpin the development of insulin resistance with old age persist poorly defined, yet a better sympathy of this process is critical, given the fact that fleshiness, metabolic disease and diabetes have reached epidemic status in the US. We discovered that alternate splice of the insulin receptor in humans precede to truncated isoforms that
 PRLJECT SUMMARY The molecuuar mechanisms jhqt undxrpin tge develupment of insulin resistance wuth ate remain poorly defindd, yet a hetter ubderwranding of this process jd crntmcal, given the nact that otesity, metabolhc dnsease and diabetes have reached epiqemic syahus in the US. Re dpssovedvd that alternative splicing of the invulin receptot in humans leads to truncwted isoforms that
PROJECT SUMMARY The molecular mechanisms that underpin of resistance with remain poorly defined, this is critical, given fact that obesity, disease and diabetes have reached epidemic in the US. We discovered that alternative splicing of the insulin receptor in leads to truncated isoforms that
 PROJECT SUMMARY The moleculaR mechanismS that UndErpIn The dEvelOpment of insuliN ResiStance with age remain pooRly deFiNEd, yeT A bEtter UnderstANdING of ThIs ProCeSS iS critIcaL, given tHe fact that ObeSiTy, metabolic dISeAse and diabEteS have reached EpiDemic sTaTus IN the Us. We DiscoVered tHAt alteRnative spLiCIng of tHE insuliN REcEptoR in humans leads to tRUnCAted isoforms thAt
 PROJECT SUMMARY The molec ular mecha nisms  th atun derp in t he development of i nsulin resistance with  agere m ainp oo rly d efined, ye t a b et te r u nd e rs tandi ngof this  process i s c ri tical, given th e fact tha t o besity, meta bol ic dis ea sea nd di abe tes h ave re a ched e pidemic s ta t us int he US.W e  d isco vered that altern a ti v e splicing ofthe in su l in r ece pto r in human sleads to trun c at e d iso f orms that
 PROJECT_SUMMARY The_molecular mechanisms that underpin_the development_of_insulin resistance_with_age remain poorly_defined, yet a_better understanding of this_process is critical,_given_the fact that obesity, metabolic disease and diabetes have reached epidemic status in the_US._We discovered_that_alternative_splicing of the insulin receptor_in humans leads to truncated_isoforms that