 deficient embryos. The specific aims of the present proposal will capitalize on recent advances in CRE- lox technology ti specifically mutate the RXRalpha gene within specific cardiovascular cell type compartments during in vivo cardiac development: 1) to determine the role of RXRalpha pathways within atrial and ventricular muscle cells in control of cardiovascular
deficient embryos. The specific aims of the present proposal will capitalize on late overture in CRE- lox technology ti specifically mutate the RXRalpha gene within specific cardiovascular cellular telephone type compartment during in vivo cardiac development: 1) to determine the function of RXRalpha pathways within atrial and ventricular muscle cell in control of cardiovascular
 devicient embryos. The speclfic aims of the presenv propoaal will capitalize on recent advancxs ib CRE- lox technology ti spezifically mutate rhe CXRalpha gene wivgin spegnfic dwrdimtascular cell tipe compartmants during in vkvl cardiac development: 1) to determine the roke of RXRalpha pwthwsrs wjnhln atrial and ventricular muscle cells pn control of carciovascular
deficient embryos. The specific aims of the will on recent in CRE- lox RXRalpha within specific cardiovascular type compartments during vivo cardiac development: 1) to determine role of RXRalpha pathways within atrial and ventricular muscle cells in control of
 deficient embryos. The specifIc aims of thE presEnt ProPoSal wIll cApitalize on recENt adVances in CRE- lox technoloGy ti sPeCIficALlY mutaTe the RXrAlPHA geNe WiThiN sPEcIfic cArdIovascuLar cell typE coMpArtments duriNG iN vivo cardiAc dEvelopment: 1) to DetErmine ThE roLE of RXralPha paThways WIthin aTrial and vEnTRiculaR Muscle cELLs In coNtrol of cardiovascULaR
 deficient embryos. The sp ecific aim s ofthe  pr es entprop osal will capi t aliz e on recent advances i n CRE -l ox t e ch nolog y ti sp e ci f i cal ly  m uta te th e RXR alp ha gene  within sp eci fi c cardiovasc u la r cell typ e c ompartmentsdur ing in  v ivo cardi acdevel opment :  1) to  determin et he rol e  of RXR a l ph a pa thways within atr i al and ventricula r musc le ce l l s i n c ontrol ofca rdiov a scular
 deficient_embryos. The_specific aims of the_present proposal_will_capitalize on_recent_advances in CRE-_lox technology ti_specifically mutate the RXRalpha_gene within specific_cardiovascular_cell type compartments during in vivo cardiac development: 1) to determine the role of_RXRalpha_pathways within_atrial_and_ventricular muscle cells in control_of cardiovascular