 was found to be a potent inducer of both zebrafish and murine HSCs and is currently being developed for use in human clinical trials for ex vivo expansion of HSCs prior to transplantation. To further characterize mechanisms controlling HSC induction in the vertebrate embryo, I plan to examine the interaction of the wnt and prostaglandin pathways
was found to be a potent inducer of both zebrafish and murine HSCs and is currently being developed for habit in human clinical test for ex vivo expansion of HSCs prior to transplantation. To further qualify mechanisms controlling HSC induction in the vertebrate embryo, I design to probe the interaction of the wnt and prostaglandin pathways
 wad found to be a potent ikducer of both zgbeafish and mhrine HSZs and is currently being deteloped fir use in human clinicxl trials for ex civo wxpansion of HSCs ixior fl trcnwplantation. To further cvaracterize mewhxnnsms controlling HSC induction in thq vertenrwte embryo, I pjan uo qxamjne the interaction of the wnt and prostajlandin pathwayx
was found to be a potent inducer zebrafish murine HSCs is currently being clinical for ex vivo of HSCs prior transplantation. To further characterize mechanisms controlling induction in the vertebrate embryo, I plan to examine the interaction of the and prostaglandin pathways
 was found to be a potent induceR of both zebRafisH anD muRiNe HScs anD is currently beINg deVeloped for use in human clInicaL tRIals FOr Ex vivO expansIOn OF hSCS pRiOr tO tRAnSplanTatIon. To fuRther charaCteRiZe mechanisms COnTrolling HSc inDuction in the VerTebratE eMbrYO, I plaN to ExamiNe the iNTeractIon of the wNt ANd prosTAglandiN PAtHwayS
 was found to be a potentinducer of  both  ze bra fi sh a nd m urine HSCs and is c urrently being develop ed fo ru se i n  h umanclinica l  t r i als  f or  ex  v i vo  expa nsi on of H SCs priortotr ansplantatio n .To further  ch aracterize m ech anisms  c ont r ollin g H SC in ductio n  in th e vertebr at e  embry o , I pla n to  exa mine the interact i on of the wnt and  prost ag l an d i n p ath ways
 was_found to_be a potent inducer_of both_zebrafish_and murine_HSCs_and is currently_being developed for_use in human clinical_trials for ex_vivo_expansion of HSCs prior to transplantation. To further characterize mechanisms controlling HSC induction in_the_vertebrate embryo,_I_plan_to examine the interaction of_the wnt and prostaglandin pathways