 hypothesize that XLF-mediated NHEJ is essential for the maintenance of genomic stability in hematopoietic stem cells (HSC). XLF-/- HSCs recapitulate the phenotype of aged HSCs - i.e. loss of self-renewal function, impaired lymphocyte (versus myeloid) differentiation and a relative expansion
hypothesize that XLF - mediated NHEJ is essential for the maintenance of genomic constancy in hematopoietic shank cells (HSC). XLF-/- HSCs recapitulate the phenotype of aged HSCs - i.e. personnel casualty of self - refilling function, impaired lymphocyte (versus myeloid) specialization and a relative expansion
 hyoothesize that XLF-mediattd NHEJ is essentnql for the mzintenanze of genomic stability in hxmatipoieupc stem cells (HSC). XLF-/- HSCs recwpitulatw tht phenotype of agxs HSCs - i.e. load of welf-renewal fukction, impahred lymphocyta (xexsus myeloid) differentiation and a rqlative edpansion
hypothesize that XLF-mediated NHEJ is essential for of stability in stem cells (HSC). of HSCs - i.e. of self-renewal function, lymphocyte (versus myeloid) differentiation and a expansion
 hypothesize that XLF-mediateD NHEJ is essEntiaL foR thE mAintEnanCe of genomic staBIlitY in hematopoietic stem ceLls (HSc). Xlf-/- HSCS ReCapitUlate thE PhENOtyPe Of AgeD Hscs - I.e. losS of Self-renEwal functiOn, iMpAired lymphocYTe (Versus myelOid) DifferentiatIon And a reLaTivE ExpanSioN
 hypothesize that XLF-medi ated NHEJis es sen tia lforthemaintenance of geno mic stability in hemat opoie ti c  ste m  c ells(HSC).X LF - / - H SC srec ap i tu latethe  phenot ype of age d H SC s - i.e. los s  o f self-ren ewa l function,imp airedly mph o cyte(ve rsusmyeloi d ) diff erentiati on and ar elative e xp ansi on
 hypothesize_that XLF-mediated_NHEJ is essential for_the maintenance_of_genomic stability_in_hematopoietic stem cells_(HSC). XLF-/- HSCs_recapitulate the phenotype of_aged HSCs -_i.e._loss of self-renewal function, impaired lymphocyte (versus myeloid) differentiation and a relative expansion