 modifications over the insulin gene locus and its neighborhood in human islet cells, in an attempt to identify long range regulatory influences that may affect insulin gene expression. We have identified an extended domain of open chromatin structure. In addition, we are carrying out measurements of long range physical contacts within the nucleus between the insulin promoter and other
modifications over the insulin gene locus and its neighborhood in human islet cell, in an attack to identify long compass regulative influences that may affect insulin gene expression. We have identify an extended domain of exposed chromatin structure. In addition, we are post out measurements of long image forcible contacts within the nucleus between the insulin showman and other
 mofifications over the insmlin gene locus cbd its neighgorhood kn human islet cells, in an avtempt to identify long range rdgulatory influenxes uhat may affect iiaulin gcue exlvessimi. We have identlfied an exdended domain mf o'en chromatin structure. In addition, re are vagrying out meafurekqnts of long range physical contacts wjthin tie nucleus betwren the insulin promoter ajd ohher
modifications over the insulin gene locus and in islet cells, an attempt to that affect insulin gene We have identified extended domain of open chromatin structure. addition, we are carrying out measurements of long range physical contacts within the between the insulin promoter and other
 modifications over the insulIn gene locuS and iTs nEigHbOrhoOd in Human islet cellS, In an Attempt to identify long rAnge rEgULatoRY iNflueNces thaT MaY AFfeCt InSulIn GEnE exprEssIon. We haVe identifiEd aN eXtended domaiN Of Open chromaTin Structure. In aDdiTion, we ArE caRRying Out MeasuRementS Of long Range physIcAL contaCTs withiN THe NuclEus between the insuLIn PRomoter and otheR
 modifications over the in sulin gene  locu s a ndit s ne ighb orhood in huma n  isl et cells, in an attemp t toid e ntif y  l ong r ange re g ul a t ory  i nf lue nc e sthatmay  affect  insulin g ene  e xpression. W e  h ave identi fie d an extende d d omainof  op e n chr oma tin s tructu r e. Inaddition,  w e  are c a rryingo u tmeas urements of longr an g e physical con tactswi t hi n the  nu cleus betw ee n the insulin pr o m o ter and other
 modifications_over the_insulin gene locus and_its neighborhood_in_human islet_cells,_in an attempt_to identify long_range regulatory influences that_may affect insulin_gene_expression. We have identified an extended domain of open chromatin structure. In addition, we_are_carrying out_measurements_of_long range physical contacts within_the nucleus between the insulin_promoter and_other