 synapses may be an important and integrated component of neuronal synaptic plasticity. Thus, we hypothesize that?9-THC exposure reduces glutamate transporter expression and activity in astroglial cells, leading to accumulation of glutamate in the synaptic cleft. This results in functional desensitization and down-regulation of the glutamate receptors on both
synapses may be an important and integrated component of neural synaptic malleability. therefore, we hypothesize that?9 - THC exposure reduces glutamate conveyer belt expression and activity in astroglial cells, lead to accumulation of glutamate in the synaptic cleft. This consequence in functional desensitization and down - regulation of the glutamate sense organ on both
 syjapses may be an importakt and integrateb compoient of neuronau synaptic plasticity. Thus, wx hypothewize that?9-THC exposure feduces gputamate traisporter expressmkn and activifn in csvroglial cells, keading to accumulation mf gputamate in the synaptic cleft. This resultx ln functional qesemfitiaation and down-regulation of the gmutamatt receptors on botn
synapses may be an important and integrated neuronal plasticity. Thus, hypothesize that?9-THC exposure activity astroglial cells, leading accumulation of glutamate the synaptic cleft. This results in desensitization and down-regulation of the glutamate receptors on both
 synapses may be an important aNd integratEd comPonEnt Of NeurOnal Synaptic plastiCIty. THus, we hypothesize that?9-THc expoSuRE redUCeS glutAmate trANsPORteR eXpResSiON aNd actIviTy in astRoglial celLs, lEaDing to accumuLAtIon of glutaMatE in the synaptIc cLeft. ThIs ResULts in FunCtionAl deseNSitizaTion and doWn-REgulatIOn of the GLUtAmatE receptors on both
 synapses may be an import ant and in tegra ted  co mp onen t of  neuronal syna p ticplasticity. Thus, we h ypoth es i ze t h at ?9-TH C expos u re r edu ce sglu ta m at e tra nsp orter e xpressionand  a ctivity in a s tr oglial cel ls,  leading toacc umulat io n o f  glut ama te in  the s y naptic  cleft. T hi s  resul t s in fu n c ti onal  desensitizationa nd down-regulatio n of t he gl u t ama tereceptorson  both 
 synapses_may be_an important and integrated_component of_neuronal_synaptic plasticity._Thus,_we hypothesize that?9-THC_exposure reduces glutamate_transporter expression and activity_in astroglial cells,_leading_to accumulation of glutamate in the synaptic cleft. This results in functional desensitization and_down-regulation_of the_glutamate_receptors_on both