 organization, and function of cell regulatory networks engaged by Ras family GTPases. Our focus is on the dominant effector pathways that mediate oncogenic Ras-induced cell transformation. Our specific aims are 1) revealing the molecular basis of the contribution of Ral GTPases to support of human tumor cell proliferation and survival; 2) assessing
organization, and function of cell regulatory net engage by Ras family GTPases. Our stress is on the dominant effecter pathways that mediate oncogenic right ascension - induce cell transformation. Our specific purpose are 1) revealing the molecular basis of the contribution of Ral GTPases to accompaniment of human tumor cell proliferation and survival; 2) assessing
 orhanization, and function uf cell regulatory netxorks ehgaged bh Ras family GTPases. Our focns iw on uke dominant effector pathways that meeiatt oncogenic Ras-invhced cell trahdforketion. Our specinic aims ara 1) revealing tve mllecular basis of the contribution jf Ral BTOases to suppott of rumah tumor cell proliferation and surbival; 2) essessing
organization, and function of cell regulatory networks Ras GTPases. Our is on the oncogenic cell transformation. Our aims are 1) the molecular basis of the contribution Ral GTPases to support of human tumor cell proliferation and survival; 2) assessing
 organization, and function of Cell regulaTory nEtwOrkS eNgagEd by ras family GTPasES. Our Focus is on the dominant efFectoR pAThwaYS tHat meDiate onCOgENIc RAs-InDucEd CElL tranSfoRmation. our specifiC aiMs Are 1) revealing THe Molecular bAsiS of the contriButIon of RAl gTPASes to SupPort oF human TUmor ceLl prolifeRaTIon and SUrvival; 2) ASSeSsinG
 organization, and functio n of cellregul ato ryne twor ks e ngaged by Rasf amil y GTPases. Our focus i s onth e  dom i na nt ef fectorp at h w ays  t ha t m ed i at e onc oge nic Ras -induced c ell  t ransformatio n .Our specif icaims are 1)rev ealing  t hem olecu lar  basi s of t h e cont ributionof Ral GT P ases to s up port  of human tumor c e ll proliferationand su rv i va l ;  2)  as sessing
 organization,_and function_of cell regulatory networks_engaged by_Ras_family GTPases._Our_focus is on_the dominant effector_pathways that mediate oncogenic_Ras-induced cell transformation._Our_specific aims are 1) revealing the molecular basis of the contribution of Ral GTPases_to_support of_human_tumor_cell proliferation and survival; 2)_assessing