 toward the metal-binding cavity, cleft or channel by fusion of rings, forming the most highly preorganized ligands known. Eight large-ring or helical complexing agents are proposed for study. Six are torands in which a large ring is formed by complete fusion of rings. Four of these torands have already been synthesized
toward the metal - binding cavity, cleft or distribution channel by coalition of rings, forming the about highly preorganized ligands sleep together. Eight large - ring or coiling complexing agent are proposed for survey. Six are torands in which a large ring is shape by complete fusion of hoop. Four of these torands have already been synthesized
 toaard the metal-binding cayity, cleft or chcbnel bb fusioh of rines, forming the most highly pceortaniztb ligands known. Eighg large-rijg or heoicao complexinj agents are pdlposzd for study. Six are torangs in which a nafgz ring is formed by complete fusion jf ringx. Vour of these jorancf habv clready been synthesized
toward the metal-binding cavity, cleft or channel of forming the highly preorganized ligands complexing are proposed for Six are torands which a large ring is formed complete fusion of rings. Four of these torands have already been synthesized
 toward the metal-binding caviTy, cleft or cHanneL by FusIoN of rIngs, Forming the most HIghlY preorganized ligands knOwn. EiGhT LargE-RiNg or hElical cOMpLEXinG aGeNts ArE PrOposeD foR study. SIx are toranDs iN wHich a large riNG iS formed by cOmpLete fusion of RinGs. Four Of TheSE toraNds Have aLready BEen synThesized
 toward the metal-bindingcavity, cl eft o r c han ne l by  fus ion of rings,f ormi ng the most highly pre organ iz e d li g an ds kn own. Ei g ht l arg e- ri ngor he lical  co mplexin g agents a repr oposed for s t ud y. Six are  to rands in whi cha larg erin g  is f orm ed by  compl e te fus ion of ri ng s . Four of thes e to rand s have already be e ns ynthesized
 toward_the metal-binding_cavity, cleft or channel_by fusion_of_rings, forming_the_most highly preorganized_ligands known. Eight_large-ring or helical complexing_agents are proposed_for_study. Six are torands in which a large ring is formed by complete fusion_of_rings. Four_of_these_torands have already been synthesized