 demonstrated that MPS VII dogs have cartilaginous lesions in the vertebrae that compromise the stability of the intervertebral joint. These lesions are caused by failed conversion of cartilage to bone during postnatal growth. In preliminary studies, we have identified the precise developmental window when abnormal ossification first manifests in MPS VII dogs
demonstrated that MPS VII dogs have cartilaginous lesions in the vertebra that compromise the constancy of the intervertebral roast. These lesions are cause by fail conversion of cartilage to bone during postnatal growth. In preliminary studies, we have identify the accurate developmental window when abnormal ossification first manifests in MPS VII dogs
 delonstrated that MPS VII aogs have cartilaginouv lesikns in tfe vertebrae that compromise tye stqbility of the interveftebral jlint. Thewe ltsions are caused by failcb conbcrsiou if cartilage tp bone durhng postnatal cruwch. In preliminary studies, we have idqntifiec hhe precise dedelokmegtal window when abnormal ossification first kanifests in KPS VII dogs
demonstrated that MPS VII dogs have cartilaginous the that compromise stability of the caused failed conversion of to bone during growth. In preliminary studies, we have the precise developmental window when abnormal ossification first manifests in MPS VII dogs
 demonstrated that MPS VII dogS have cartiLaginOus LesIoNs in The vErtebrae that coMPromIse the stability of the inTerveRtEBral JOiNt. TheSe lesioNS aRE CauSeD bY faIlED cOnverSioN of cartIlage to bonE duRiNg postnatal gROwTh. In prelimInaRy studies, we hAve IdentiFiEd tHE precIse DevelOpmentAL windoW when abnoRmAL ossifICation fIRSt ManiFests in MPS VII dogs
 demonstrated that MPS VII  dogs have  cart ila gin ou s le sion s in the verte b raethat compromise the st abili ty of t h einter vertebr a lj o int .Th ese  l e si ons a recausedby failedcon ve rsion of car t il age to bon e d uring postna tal  growt h.  In preli min ary s tudies ,  we ha ve identi fi e d thep recised e ve lopm ental window when ab n ormal ossifica tion f ir s tm a nif est s in MPS V II  dogs 
 demonstrated_that MPS_VII dogs have cartilaginous_lesions in_the_vertebrae that_compromise_the stability of_the intervertebral joint._These lesions are caused_by failed conversion_of_cartilage to bone during postnatal growth. In preliminary studies, we have identified the precise_developmental_window when_abnormal_ossification_first manifests in MPS VII_dogs