 1 (HIF1), a critical transcription factor for VEGF gene regulation. Our recent data and other published studies suggest that OSM may promote angiogenesis, tumor progression, and metastasis in vivo. In this grant, we propose to determine the multiple mechanisms by which OSM promotes VEGF expression in human breast cancer. To accomplish this
1 (HIF1), a critical transcription factor for VEGF gene regulation. Our recent datum and early print studies suggest that OSM may advertise angiogenesis, tumor progression, and metastasis in vivo. In this grant, we propose to specify the multiple mechanisms by which OSM promotes VEGF saying in human breast cancer. To accomplish this
 1 (HLF1), a critical transcriptlon factor for VGGD gene regulztion. Ouf recent data and other publmshee stueies suggest that OSM oay promone angiogwnesms, tumor progression, and metasfwsis mn vivo. In this grant, we [ropose to detaroiue the multiple mechanisms by which JSM prokohes VEGF exprefsiom in glmcn breast cancer. To accomplish fhis
1 (HIF1), a critical transcription factor for regulation. recent data other published studies angiogenesis, progression, and metastasis vivo. In this we propose to determine the multiple by which OSM promotes VEGF expression in human breast cancer. To accomplish this
 1 (HIF1), a critical transcription Factor for VeGF geNe rEguLaTion. our rEcent data and otHEr puBlished studies suggest tHat OSm mAY proMOtE angiOgenesiS, TuMOR prOgReSsiOn, ANd MetasTasIs in vivO. In this graNt, wE pRopose to deteRMiNe the multiPle Mechanisms by WhiCh OSM pRoMotES VEGF ExpRessiOn in huMAn breaSt cancer. TO aCCompliSH this
 1 (HIF1), a critical tran scriptionfacto r f orVE GF g eneregulation. Ou r  rec ent data and other pub lishe ds tudi e ssugge st that OS M may  p ro mot ea ng iogen esi s, tumo r progress ion ,and metastas i sin vivo. I n t his grant, w e p ropose  t o d e termi nethe m ultipl e  mecha nisms bywh i ch OSM promote s VE GF e xpression in huma n  b r east cancer. T o acco mp l is h thi s
 1_(HIF1), a_critical transcription factor for_VEGF gene_regulation._Our recent_data_and other published_studies suggest that_OSM may promote angiogenesis,_tumor progression, and_metastasis_in vivo. In this grant, we propose to determine the multiple mechanisms by which_OSM_promotes VEGF_expression_in_human breast cancer. To accomplish_this