 be analyzed for differences in intracellular localization;and 3) a search will be conducted for Akt2-specific substrates. It is anticipated that these studies will significantly extend the knowledge of physiological insulin-independent signaling and ultimately lead to the identification of potential targets for therapeutic intervention in diabetes mellitus. The spatial distribution of energy from ionizing
be analyzed for differences in intracellular localization;and 3) a search will be conducted for Akt2 - specific substrates. It is anticipate that these cogitation will significantly cover the cognition of physiological insulin - independent signaling and ultimately conduct to the identification of potential target for therapeutic intervention in diabetes mellitus. The spatial distribution of department of energy from ionizing
 be analyzed for differencer in intracellular locelizatikn;and 3) a search will be conducted foc Akr2-specufic substrates. It is xnticipatvd that tyese wtudies will signinncantmn extznv the knowledge of physionogical insulit-ivdzpendent signaling and ultimately lewd to tne identificatiog of [otehnicl targets for therapeutic intedventioi in diabetes mrllitus. The spatial distrihutiln of energy from lonizing
be analyzed for differences in intracellular localization;and search be conducted Akt2-specific substrates. It will extend the knowledge physiological insulin-independent signaling ultimately lead to the identification of targets for therapeutic intervention in diabetes mellitus. The spatial distribution of energy from
 be analyzed for differences iN intracellUlar lOcaLizAtIon;aNd 3) a sEarch will be conDUcteD for Akt2-specific substraTes. It Is ANticIPaTed thAt these STuDIEs wIlL sIgnIfICaNtly eXteNd the knOwledge of pHysIoLogical insulIN-iNdependent SigNaling and ultImaTely leAd To tHE idenTifIcatiOn of poTEntial Targets foR tHErapeuTIc interVENtIon iN diabetes mellitus. tHe SPatial distribuTion of EnERgY FRom IonIzing
 be analyzed for differenc es in intr acell ula r l oc aliz atio n;and 3) a sea r ch w ill be conducted for A kt2-s pe c ific su bstra tes. It is a nti ci pa ted  t h at  thes e s tudieswill signi fic an tly extend t h eknowledgeofphysiologica l i nsulin -i nde p enden t s ignal ing an d  ultim ately lea dt o thei dentifi c a ti on o f potential targe t sf or therapeutic  inter ve n ti o n  in  di abetes mel li tus.T he spat i al d i str i bution of ene rgy from io n izi ng
 be_analyzed for_differences in intracellular localization;and_3) a_search_will be_conducted_for Akt2-specific substrates._It is anticipated_that these studies will_significantly extend the_knowledge_of physiological insulin-independent signaling and ultimately lead to the identification of potential targets for_therapeutic_intervention in_diabetes_mellitus._The spatial distribution of energy_from ionizing