 essential neurotransmitters. Botulinum neurotoxin proteases are unique among endopeptidases in that they require long substrates (SNAREs) for catalytic efficiency due to their recognition strategy. Further complicating their inhibition are allosteric patches, termed exosites that both determine specificity and also remodel the
essential neurotransmitters. Botulinum neurotoxin proteases are unique among endopeptidases in that they command retentive substrates (SNAREs) for catalytic efficiency due to their recognition strategy. far complicating their inhibition are allosteric patch, termed exosites that both determine specificity and besides recast the
 esdential neurotransmitterr. Botulinum neutoroxin 'roteasss are uvique among endopeptidases ii thqt thtj require long substrxtes (SNARVs) for caralyuic efficiency dux to thelx recknnitimi strategy. Furtmer complicdting their invicicion are allosteric patches, termed evosites tjat both deteriine fpecjficity and also remodel the
essential neurotransmitters. Botulinum neurotoxin proteases are unique in they require substrates (SNAREs) for recognition Further complicating their are allosteric patches, exosites that both determine specificity and remodel the
 essential neurotransmitterS. Botulinum NeuroToxIn pRoTeasEs arE unique among enDOpepTidases in that they requiRe lonG sUBstrATeS (SNARes) for caTAlYTIc eFfIcIenCy DUe To theIr rEcognitIon strategY. FuRtHer complicatINg Their inhibItiOn are allosteRic PatcheS, tErmED exosIteS that Both deTErmine SpecificiTy ANd also REmodel tHE
 essential neurotransmitte rs. Botuli num n eur oto xi n pr otea ses are unique amon g endopeptidases in th at th ey requ i re  long  substr a te s (SN AR Es ) f or ca talyt icefficie ncy due to  th ei r recognitio n  s trategy. F urt her complica tin g thei rinh i bitio n a re al loster i c patc hes, term ed exosit e s thatb o th  det ermine specificit y  a n d also remodel  the
 essential_neurotransmitters. Botulinum_neurotoxin proteases are unique_among endopeptidases_in_that they_require_long substrates (SNAREs)_for catalytic efficiency_due to their recognition_strategy. Further complicating_their_inhibition are allosteric patches, termed exosites that both determine specificity and also remodel the