 Ligand-mediated TCR degradation is inhibitable both by reagents that block vesicular acidification and by inhibitors of the ubiquitin/proteasome pathway, suggesting a complex pathway leading to TCR degradation. Our determination that the TCR is a substrate for ubiquitination has led us to evaluate ubiquitination in more detail. A family of human
Ligand - mediated TCR degradation is inhibitable both by reagents that block vesicular acidification and by inhibitor of the ubiquitin / proteasome nerve pathway, suggest a complex pathway leading to TCR abasement. Our determination that the TCR is a substrate for ubiquitination has led us to evaluate ubiquitination in more contingent. A kin of human
 Lihand-mediated TCR degradauion is inhibitable both by rezgents tfat block vesicular acidificetiob and by inhibitors of the jbiquitin/iroteasomw pauhway, suggesting e complew patgaay nxading to TCR dggradation. Ogr determinatimn tkat the TCR is a substrate for ubiquytinatipn has led us to evaktate lblquitination in more detail. A fajily of human
Ligand-mediated TCR degradation is inhibitable both by block acidification and inhibitors of the pathway to TCR degradation. determination that the is a substrate for ubiquitination has us to evaluate ubiquitination in more detail. A family of human
 Ligand-mediated TCR degradatIon is inhibItablE boTh bY rEageNts tHat block vesicuLAr acIdification and by inhibiTors oF tHE ubiQUiTin/prOteasomE PaTHWay, SuGgEstInG A cOmpleX paThway leAding to TCR DegRaDation. Our detERmInation thaT thE TCR is a substRatE for ubIqUitINatioN haS led uS to evaLUate ubIquitinatIoN In more DEtail. A fAMIlY of hUman
 Ligand-mediated TCR degra dation isinhib ita ble  b othby r eagents that b l ockvesicular acidificatio n and  b y  inh i bi torsof theu bi q u iti n/ pr ote as o me  path way , sugge sting a co mpl ex  pathway lea d in g to TCR d egr adation. Our  de termin at ion thatthe  TCRis a s u bstrat e for ubi qu i tinati o n has l e d  u s to  evaluate ubiquit i na t ion in more de tail.Af am i l y o f h uman
 Ligand-mediated_TCR degradation_is inhibitable both by_reagents that_block_vesicular acidification_and_by inhibitors of_the ubiquitin/proteasome pathway,_suggesting a complex pathway_leading to TCR_degradation._Our determination that the TCR is a substrate for ubiquitination has led us to_evaluate_ubiquitination in_more_detail._A family of human