 inflammation after sensitization with house dust mite antigen, a common allergic asthma model. This heightened inflammation results in greater in vivo airway reactivity. We also demonstrate that gabra4 knockout CD4+ cells express increased inflammatory cytokines compared to wild type CD4+ cells when stimulated via the T cell receptor in vitro, suggesting
inflammation after sensitization with house dust touch antigen, a coarse allergic asthma model. This heightened inflammation result in great in vivo airway reactivity. We besides demonstrate that gabra4 knockout CD4 + cells carry increased inflammatory cytokine compared to wild type CD4 + cells when provoke via the T cell receptor in vitro, suggesting
 invlammation after sensitieation with house dust mmte antjgen, a cummon allergic asthma model. Vhis heigytened inflammation rerults in hreater un vmvo airway reactmbity. We also scmonscrete that gabra4 lnockout CG4+ cells expresv knereased inflammatory cytokines compawed to eipd type CD4+ celjs wnqn sfpmmlated via the T cell receptor ih vitro, suggesting
inflammation after sensitization with house dust mite common asthma model. heightened inflammation results reactivity. also demonstrate that knockout CD4+ cells increased inflammatory cytokines compared to wild CD4+ cells when stimulated via the T cell receptor in vitro, suggesting
 inflammation after sensitizAtion with hOuse dUst MitE aNtigEn, a cOmmon allergic aSThma Model. This heightened infLammaTiON resULtS in grEater in VIvO AIrwAy ReActIvITy. we alsO deMonstraTe that gabrA4 knOcKout CD4+ cells eXPrEss increasEd iNflammatory cYtoKines cOmParED to wiLd tYpe CD4+ Cells wHEn stimUlated via ThE t cell rECeptor iN VItRo, suGgesting
 inflammation after sensit ization wi th ho use  du st  mit e an tigen, a commo n  all ergic asthma model. Th is he ig h tene d  i nflam mationr es u l tsin  g rea te r  i n viv o a irway r eactivity.  We  a lso demonstr a te  that gabr a4knockout CD4 + c ells e xp res s  incr eas ed in flamma t ory cy tokines c om p ared t o  wild t y p eCD4+  cells when stimu l at e d via the T ce ll rec ep t or i n v itr o, suggest in g
 inflammation_after sensitization_with house dust mite_antigen, a_common_allergic asthma_model._This heightened inflammation_results in greater_in vivo airway reactivity._We also demonstrate_that_gabra4 knockout CD4+ cells express increased inflammatory cytokines compared to wild type CD4+ cells_when_stimulated via_the_T_cell receptor in vitro, suggesting