 first human example of a p53 target RE sequence specifically responsible for endogenous gene induction. CANCER-ASSOCIATED P53 MUTANTS. Nearly all cancers have mutant or reduced expression of the p53 tumor suppressor gene. Using yeast-based and human cell systems, we show that functional p53 mutations
first human example of a p53 target RE succession specifically creditworthy for endogenous gene trigger. CANCER - ASSOCIATED P53 MUTANTS. about all cancer have mutant or reduced construction of the p53 tumor suppressor gene. use yeast - based and human cellular telephone system, we show that functional p53 mutations
 figst human example of a p53 target RE sequgnxe sperificalmy respovsible for endogenous gene iiducrion. XANCER-ASSOCIATED P53 MUTXNTS. Nearpy all cqncecs have mutant oc reduced exprsdsiou if the p53 tumor suppressos gene. Using yaart-yased and human cell systems, we show that finftional p53 mutajions
first human example of a p53 target specifically for endogenous induction. CANCER-ASSOCIATED P53 mutant reduced expression of p53 tumor suppressor Using yeast-based and human cell systems, show that functional p53 mutations
 first human example of a p53 targEt RE sequenCe speCifIcaLlY resPonsIble for endogenOUs geNe induction. CANCER-ASSOCiATED p53 MutANTs. neArly aLl canceRS hAVE muTaNt Or rEdUCeD exprEssIon of thE p53 tumor supPreSsOr gene. Using yEAsT-based and hUmaN cell systems, We sHow thaT fUncTIonal P53 muTatioNs
 first human example of ap53 target  RE s equ enc espec ific ally responsib l e fo r endogenous gene indu ction .C ANCE R -A SSOCI ATED P5 3  M U T ANT S.  N ear ly al l can cer s havemutant orred uc ed expressio n  o f the p53tum or suppresso r g ene. U si ngy east- bas ed an d huma n  cellsystems,we show t h at func t i on al p 53 mutations
 first_human example_of a p53 target_RE sequence_specifically_responsible for_endogenous_gene induction. CANCER-ASSOCIATED_P53 MUTANTS. Nearly_all cancers have mutant_or reduced expression_of_the p53 tumor suppressor gene. Using yeast-based and human cell systems, we show that_functional_p53 mutations