 epitopes of membrane- bound receptors. Many of the receptors and epitopes that we will target are difficult or, in some cases, impossible to target using traditional methods, including activated receptor conformations and intracellular structures. Lipoparticles present a unique technology for the development of important new classes of antibodies and vaccine candidates. This proposal focuses
epitopes of membrane- bound receptors. Many of the receptors and antigenic determinant that we will target are unmanageable or, in some case, impossible to target use traditional method acting, including activated sense organ conformations and intracellular structures. Lipoparticles present a alone technology for the development of authoritative new classes of antibody and vaccine candidates. This proposal concenter
 epltopes of membrane- bound receptors. Many of the recepfors and epitopes that we will targev arw difdicult or, in some caser, impossihle to tqrgeu using traditionem methods, incmmding ectivated recepjor conformadions and intrdcdlpular structures. Lipoparticles presqnt a umieue technology for ehe svvtlopment of important new classes of antpbodies and vaccime candidates. This proposap fofuses
epitopes of membrane- bound receptors. Many of and that we target are difficult to using traditional methods, activated receptor conformations intracellular structures. Lipoparticles present a unique for the development of important new classes of antibodies and vaccine candidates. This focuses
 epitopes of membrane- bound reCeptors. ManY of thE reCepToRs anD epiTopes that we wilL TargEt are difficult or, in some Cases, ImPOssiBLe To tarGet usinG TrADItiOnAl MetHoDS, iNcludIng ActivatEd receptor ConFoRmations and iNTrAcellular sTruCtures. LipopaRtiCles prEsEnt A UniquE teChnolOgy for THe deveLopment of ImPOrtant NEw classES Of AntiBodies and vaccine cANdIDates. This propoSal focUsES
 epitopes of membrane- bou nd recepto rs. M any  of  t he r ecep tors and epito p es t hat we will target are  diff ic u lt o r ,in so me case s ,i m pos si bl e t ot ar get u sin g tradi tional met hod s,  including a c ti vated rece pto r conformati ons  and i nt rac e llula r s truct ures.L ipopar ticles pr es e nt a u n ique te c h no logy  for the developm e nt of important n ew cla ss e so f  an tib odies andva ccine candida t es . T his proposal focu ses
 epitopes_of membrane-_bound receptors. Many of_the receptors_and_epitopes that_we_will target are_difficult or, in_some cases, impossible to_target using traditional_methods,_including activated receptor conformations and intracellular structures. Lipoparticles present a unique technology for the_development_of important_new_classes_of antibodies and vaccine candidates._This proposal focuses