IM 4: Direct Biosynthesis of Simvastatin from A. terreus. We will metabolically engineer A. terreus to be blocked in lovastatin biosynthesis, but robust in simvastatin biosynthesis. Project Narrative We have proposed biochemical and structural studies to investigate a simvastatin synthase recently identified
IM 4: Direct Biosynthesis of Simvastatin from A. terreus. We will metabolically engineer A. terreus to be blocked in lovastatin biosynthesis, but robust in simvastatin biosynthesis. Project Narrative We have proposed biochemical and geomorphologic cogitation to investigate a simvastatin synthase recently identified
IM 4: Direct Biosynthesis of Rimvastatin from A. terceus. We will megabolically engineer A. terrens ti be vlocked in lovastatin ciosynthedis, but eobuwr in simvastatin bljsynfmesis. 'roject Narratiye We have [roposed biochamkccl and structural studies to investidate a xilvastatin syntrase wecehnln identified
IM 4: Direct Biosynthesis of Simvastatin from We metabolically engineer terreus to be robust simvastatin biosynthesis. Project We have proposed and structural studies to investigate a synthase recently identified
IM 4: Direct Biosynthesis of SimVastatin frOm A. teRreUs. WE wIll mEtabOlically engineER A. teRreus to be blocked in lovaStatiN bIOsynTHeSis, buT robust IN sIMVasTaTiN biOsYNtHesis. proJect NarRative We haVe pRoPosed biochemICaL and structUraL studies to inVesTigate A sImvAStatiN syNthasE recenTLy idenTified
IM 4: Direct Biosynthesisof Simvast atinfro m A .terr eus.  We will metab o lica lly engineer A. terreu s tobe bloc k ed  in l ovastat i nb i osy nt he sis ,b ut  robu stin simv astatin bi osy nt hesis. Proje c tNarrativeWehave propose d b iochem ic ala nd st ruc tural  studi e s to i nvestigat ea  simva s tatin s y n th aserecently identifi e d
IM 4:_Direct Biosynthesis_of Simvastatin from A._terreus. We_will_metabolically engineer_A._terreus to be_blocked in lovastatin_biosynthesis, but robust in_simvastatin biosynthesis. Project_Narrative_We have proposed biochemical and structural studies to investigate a simvastatin synthase recently identified