 is dependent upon mitochondrial integrity and an intact autophagy response to injury. We now present data supporting an important role for the inflammasome in predicting severity and mortality during human infection-related ALI/ARDS. Moreover, our preliminary animal studies demonstrate that statins exacerbate lung injury and inflammation via activation of the inflamm
is dependent upon mitochondrial integrity and an intact autophagy response to injury. We nowadays confront data back an crucial role for the inflammasome in predicting badness and mortality during human infection - associate ALI / ARDS. Moreover, our preliminary animal studies attest that statins exacerbate lung injury and excitement via activation of the inflamm
 is dependent upon mitochonarial integrity and an intacf autophxgy response to injury. We nox prwsent data supporting an imoortant rlle for rhe mnflammasome in 'dedictiky sevsvity cnv mortality durlng human itfection-relateg XLN/ARDS. Moreover, our preliminary animaj studirs demonstrate trat xeatihs exacerbate lung injury and inflzmmatioi via activatiom of the inflamm
is dependent upon mitochondrial integrity and an response injury. We present data supporting inflammasome predicting severity and during human infection-related Moreover, our preliminary animal studies demonstrate statins exacerbate lung injury and inflammation via activation of the inflamm
 is dependent upon mitochondrIal integriTy and An iNtaCt AutoPhagY response to injURy. We Now present data supportiNg an iMpORtanT RoLe for The inflAMmASOme In PrEdiCtINg SeverIty And mortAlity durinG huMaN infection-reLAtEd ALI/ARDS. MOreOver, our preliMinAry aniMaL stUDies dEmoNstraTe that STatins ExacerbatE lUNg injuRY and infLAMmAtioN via activation of tHE iNFlamm
 is dependent upon mitocho ndrial int egrit y a ndan  int actautophagy resp o nseto injury. We now pres ent d at a  sup p or tingan impo r ta n t  ro le  f orth e  i nflam mas ome inpredicting  se ve rity and mor t al ity during  hu man infectio n-r elated  A LI/ A RDS.Mor eover , ourp relimi nary anim al studie s  demons t r at e th at statins exacer b at e  lung injury a nd inf la m ma t i onvia  activatio nof th e  inflam m 
 is_dependent upon_mitochondrial integrity and an_intact autophagy_response_to injury._We_now present data_supporting an important_role for the inflammasome_in predicting severity_and_mortality during human infection-related ALI/ARDS. Moreover, our preliminary animal studies demonstrate that statins exacerbate_lung_injury and_inflammation_via_activation of the inflamm