iveness and increased vascular permeability are dependent on the presence of extravascular polymorphonuclear leukocytes (PMNs) in the airways. This proposal will first examine which chemoattractants are responsible for bringing PMNs to the site of airway injury. Animals either 1) depleted of complement, 2) treated with an inhibitor of the
iveness and increased vascular permeability are dependent on the presence of extravascular polymorphonuclear leukocytes (PMNs) in the respiratory tract. This marriage proposal will first examine which chemoattractants are creditworthy for bringing PMNs to the web site of airway injury. animal either 1) depleted of complement, 2) treated with an inhibitor of the
ivejess and increased vascuuar permeabiliti qre de'endent on the oresence of extravascular popynorphinuclear leukocytes (PMVs) in the airways. Thiw proposal xjll first exajlne wkirh chemoattractsnts are rasponsible for bfiuging PMNs to the site of airway injtry. Anikaps either 1) depjetec of domplement, 2) treated with an inhibifor of uhe
iveness and increased vascular permeability are dependent presence extravascular polymorphonuclear (PMNs) in the examine chemoattractants are responsible bringing PMNs to site of airway injury. Animals either depleted of complement, 2) treated with an inhibitor of the
iveness and increased vasculAr permeabiLity aRe dEpeNdEnt oN the Presence of extrAVascUlar polymorphonuclear lEukocYtES (PMNS) In The aiRways. ThIS pROPosAl WiLl fIrST eXaminE whIch chemOattractanTs aRe Responsible fOR bRinging PMNS to The site of airWay Injury. anImaLS eithEr 1) dEpletEd of coMPlemenT, 2) treated wItH An inhiBItor of tHE
iveness and increased vasc ular perme abili tyare  d epen dent  on the presen c e of  extravascular polymor phonu cl e ar l e uk ocyte s (PMNs )  i n the  a ir way s. Th is pr opo sal wil l first ex ami ne  which chemo a tt ractants a reresponsiblefor  bring in g P M Ns to  th e sit e of a i rway i njury. An im a ls eit h er 1) d e p le tedof complement, 2) tr e ated with an i nhibit or of t he
iveness and_increased vascular_permeability are dependent on_the presence_of_extravascular polymorphonuclear_leukocytes_(PMNs) in the_airways. This proposal_will first examine which_chemoattractants are responsible_for_bringing PMNs to the site of airway injury. Animals either 1) depleted of complement,_2)_treated with_an_inhibitor_of the