 the hyper-inflammatory phenotype of the gabra4 knockout mouse may be CD4+ cell-mediated. We hypothesize that GABAA receptor currents, which are depolarizing in CD4+ cells, alter calcium signaling processes key in lymphocyte activation and function, specifically calcium oscillations and store-operated calcium entry. We propose
the hyper - inflammatory phenotype of the gabra4 knockout mouse may be CD4 + cell - mediated. We hypothesize that GABAA sense organ stream, which are depolarizing in CD4 + cells, interpolate calcium signal processes key in lymphocyte activation and affair, specifically calcium oscillations and store - operate calcium entry. We propose
 thf hyper-inflammatory phenutype of the gayea4 knorkout mkuse may be CD4+ cell-mediated. We hypotiesize thqt GABAA receptor currdnts, whicj are depolacizing in CD4+ cells, alter calcihl siyneling processes key in lykphocyte activdtkou and function, specifically calcium jscillayilns and store-okerattd salcjlm entry. We propose
the hyper-inflammatory phenotype of the gabra4 knockout be cell-mediated. We that GABAA receptor CD4+ alter calcium signaling key in lymphocyte and function, specifically calcium oscillations and calcium entry. We propose
 the hyper-inflammatory phenoType of the gAbra4 kNocKouT mOuse May bE CD4+ cell-mediateD. we hyPothesize that GABAA recePtor cUrREnts, WHiCh are DepolarIZiNG In Cd4+ cElLs, aLtER cAlciuM siGnaling Processes kEy iN lYmphocyte actIVaTion and funCtiOn, specificalLy cAlcium OsCilLAtionS anD storE-operaTEd calcIum entry. WE pROpose
 the hyper-inflammatory ph enotype of  thegab ra4  k nock outmouse may be C D 4+ c ell-mediated. We hypot hesiz et hatG AB AA re ceptorc ur r e nts ,wh ich  a r edepol ari zing in  CD4+ cell s,al ter calciums ig naling pro ces ses key in l ymp hocyte  a cti v ation  an d fun ction, specif ically ca lc i um osc i llation s an d st ore-operated calc i um entry. We prop ose
 the_hyper-inflammatory phenotype_of the gabra4 knockout_mouse may_be_CD4+ cell-mediated._We_hypothesize that GABAA_receptor currents, which_are depolarizing in CD4+_cells, alter calcium_signaling_processes key in lymphocyte activation and function, specifically calcium oscillations and store-operated calcium entry._We_propose