 of amphetamine and related compounds will encompass both clinical and experimental studies in order to evaluate both the factors controlling the rate and routes of metabolism and the pharmacological properties of active metabolites. Significant improvements are anticipated in the sensitivity and accuracy of chemical assays and in methods of quantitative evaluation of clinical response to these drugs. Project Summary: B
of amphetamine and related compounds will encompass both clinical and experimental studies in order to measure both the divisor controlling the rate and path of metamorphosis and the pharmacological properties of active metabolites. Significant improvement are anticipated in the sensitivity and accuracy of chemical assays and in method of quantitative evaluation of clinical response to these drugs. Project Summary: bel
 of amphetamine and related compounds will encompess botg clinicxl and experimental studies mn oeder uj evaluate both thd factors controloing rhe rate ais routes of msbabolnsn and the pharkacologican properties ox xccive metabolites. Significant improveients ate anticipated ig tht sqnsifpvlty and accuracy of chemical asszys and in methods og quantitative evaluation lf cpinical response tl these druts. Pwiject Summarh: B
of amphetamine and related compounds will encompass and studies in to evaluate both and of metabolism and pharmacological properties of metabolites. Significant improvements are anticipated in sensitivity and accuracy of chemical assays and in methods of quantitative evaluation of response to these drugs. Project Summary: B
 of amphetamine and related coMpounds wilL encoMpaSs bOtH cliNicaL and experimentAL stuDies in order to evaluate bOth thE fACtorS CoNtrolLing the RAtE ANd rOuTeS of MeTAbOlism And The pharMacologicaL prOpErties of actiVE mEtabolites. sigNificant imprOveMents aRe AntICipatEd iN the sEnsitiVIty and Accuracy oF cHEmical ASsays anD IN mEthoDs of quantitative eVAlUAtion of clinicaL respoNsE To THEse DruGs. Project SUmMary: B
 of amphetamine and relate d compound s wil l e nco mp assboth  clinical ande xper imental studies in ord er to  e v alua t eboththe fac t or s con tr ol lin gt he  rate  an d route s of metab oli sm  and the pha r ma cologicalpro perties of a cti ve met ab oli t es. S ign ifica nt imp r ovemen ts are an ti c ipated in thes e ns itiv ity and accuracyo fc hemical assays  and i nm et h o dsofquantitati ve  eval u ation o f  c l i n ica l  response tothese drugs .  Pr ojectSu mma r y: B
 of_amphetamine and_related compounds will encompass_both clinical_and_experimental studies_in_order to evaluate_both the factors_controlling the rate and_routes of metabolism_and_the pharmacological properties of active metabolites. Significant improvements are anticipated in the sensitivity and_accuracy_of chemical_assays_and_in methods of quantitative evaluation_of clinical response to these_drugs. Project_Summary: B