 the lowest common mediator necessary for activation of both Bim and calcineurin and hence positive and negative selection. We will then determine the mechanism by which this molecule is induced to channel high intensity signals to Bim and low intensity signals to calcineurin. We will also define the processes downstream of calcineurin that mediate
the lowest common mediator necessary for activation of both Bim and calcineurin and hence incontrovertible and damaging selection. We will then determine the mechanism by which this molecule is induce to channel high saturation signal to Bim and low intensity signals to calcineurin. We will also specify the processes downstream of calcineurin that intercede
 thf lowest common mediator necessary for cxtivatmon of goth Bim and calcineurin and hence plsutive and negative selectiov. We will then derermmne the mechanism by whigk thia molzcnle is induced jo channel hhgh intensity viencls to Bim and low intensity signals to calvijeurin. We will alsp defjne the processes downstream of camcineurpn that mediate
the lowest common mediator necessary for activation Bim calcineurin and positive and negative the by which this is induced to high intensity signals to Bim and intensity signals to calcineurin. We will also define the processes downstream of calcineurin mediate
 the lowest common mediator neCessary for ActivAtiOn oF bOth BIm anD calcineurin anD HencE positive and negative seLectiOn. wE wilL ThEn detErmine tHE mECHanIsM bY whIcH ThIs molEcuLe is indUced to chanNel HiGh intensity sIGnAls to Bim anD loW intensity siGnaLs to caLcIneURin. We WilL also Define THe procEsses downStREam of cALcineurIN ThAt meDiate
 the lowest common mediato r necessar y for  ac tiv at ionof b oth Bim and ca l cine urin and hence positiv e and  n e gati v eselec tion. W e  w i l l t he ndet er m in e the  me chanism  by whichthi smolecule isi nd uced to ch ann el high inte nsi ty sig na lst o Bim  an d low  inten s ity si gnals toca l cineur i n. We w i l lalso  define the proce s se s  downstream of  calci ne u ri n tha t m ediate
 the_lowest common_mediator necessary for activation_of both_Bim_and calcineurin_and_hence positive and_negative selection. We_will then determine the_mechanism by which_this_molecule is induced to channel high intensity signals to Bim and low intensity signals_to_calcineurin. We_will_also_define the processes downstream of_calcineurin that mediate