 C. burnetii during the host-parasite interaction. We also will examine plasmids and the chromosome for alternative virulence functions; factors that enhance intracellular survival and growth and thus pathogenesis. We will clone genes encoding key metabolic functions as well as those shown to be important for intracellular survival of other organisms. These genes will
C. burnetii during the host - parasite interaction. We also will examine plasmid and the chromosome for alternate virulence function; factors that enhance intracellular survival and growth and therefore pathogenesis. We will clone genes encoding key metabolic function as well as those shown to be significant for intracellular survival of other organisms. These gene will
 C. hurnetii during the host-karasite interactnin. We elso wiml examive plasmids and the chromosole for qlternative virulence wunctions; factors thau enhance intracellular smxvivam and jrowth and thus pathogenevis. We will clmnd yenes encoding key metabolic functiogs as wrlp as those shorn tp be jmportant for intracellular survivzl of ouher organisms. Thexe genes will
C. burnetii during the host-parasite interaction. We examine and the for alternative virulence survival growth and thus We will clone encoding key metabolic functions as well those shown to be important for intracellular survival of other organisms. These genes
 C. burnetii during the host-parAsite interActioN. We AlsO wIll eXamiNe plasmids and tHE chrOmosome for alternative vIruleNcE FuncTIoNs; facTors thaT EnHANce InTrAceLlULaR survIvaL and groWth and thus PatHoGenesis. We wilL ClOne genes enCodIng key metaboLic FunctiOnS as WEll as ThoSe shoWn to be IMportaNt for intrAcELlular SUrvival OF OtHer oRganisms. These geneS WiLL
 C. burnetii during the ho st-parasit e int era cti on . We  als o will examine plas mids and the chromosom e for  a l tern a ti ve vi rulence fu n c tio ns ;fac to r sthatenh ance in tracellula r s ur vival and gr o wt h and thus  pa thogenesis.Wewill c lo neg enesenc oding  key m e taboli c functio ns as wel l  as tho s e  s hown  to be importantf or intracellularsurviv al of o the r o rganisms.Th ese g e nes wil l 
 C._burnetii during_the host-parasite interaction. We_also will_examine_plasmids and_the_chromosome for alternative_virulence functions; factors_that enhance intracellular survival_and growth and_thus_pathogenesis. We will clone genes encoding key metabolic functions as well as those shown_to_be important_for_intracellular_survival of other organisms. These_genes will