 which Atg5 and/or autophagy mediates signaling through TLR9 upon HSV infection in pDCs through the use of molecular and cellular biological techniques. In the second Aim, we propose to determine how autophagy regulates RNA sensor activation upon VSV infection through proteomics and biochemical approaches. In the final Aim, we will interrogate
which Atg5 and/or autophagy mediates signaling through TLR9 upon HSV infection in pDCs through the use of molecular and cellular biological techniques. In the second purpose, we nominate to determine how autophagy regulates RNA sensor energizing upon VSV infection through proteomics and biochemical approaches. In the final purpose, we will interrogate
 whlch Atg5 and/or autophagy oediates signalnbg thrmugh TMR9 upon FSV infection in pDCs througi thw use of molecular and celljlar biollgical twchnmques. In the second Aim, we prollse co determine how autophagy regulates RNA sdndor activation upon VSV infection trrough lrlteomics and byochtmisal zipvoaches. In the final Aim, we will interrmgate
which Atg5 and/or autophagy mediates signaling through HSV in pDCs the use of In second Aim, we to determine how regulates RNA sensor activation upon VSV through proteomics and biochemical approaches. In the final Aim, we will interrogate
 which Atg5 and/or autophagy medIates signaLing tHroUgh tLr9 upoN HSV Infection in pDCS ThroUgh the use of molecular anD cellUlAR bioLOgIcal tEchniquES. IN THe sEcOnD AiM, wE PrOpose To dEterminE how autophAgy ReGulates RNA seNSoR activatioN upOn VSV infectiOn tHrough PrOteOMics aNd bIocheMical aPProachEs. In the fiNaL aim, we wILl interROGaTe
 which Atg5 and/or autopha gy mediate s sig nal ing  t hrou gh T LR9 upon HSV i n fect ion in pDCs through th e use  o f  mol e cu lar a nd cell u la r bio lo gi cal  t e ch nique s.In thesecond Aim , w epropose to d e te rmine howaut ophagy regul ate s RNAse nso r  acti vat ion u pon VS V  infec tion thro ug h  prote o mics an d bi oche mical approaches. In the final Aim,  we wi ll in t e rro gat e
 which_Atg5 and/or_autophagy mediates signaling through_TLR9 upon_HSV_infection in_pDCs_through the use_of molecular and_cellular biological techniques. In_the second Aim,_we_propose to determine how autophagy regulates RNA sensor activation upon VSV infection through proteomics_and_biochemical approaches._In_the_final Aim, we will interrogate