eding bone metastases and associated osteolytic disease. Aim 4: To determine whether targeted Wwox ablation in the mammary gland leads to enhanced mammary tumorigenesis and increases metastasis. The proposed studies will provide novel information on the mechanistic basis of bone metastasis development and identify potential novel targets for therapeutic intervention. PUBLIC HEALTH RELEVANCE:
eding bone metastases and associated osteolytic disease. Aim 4: To determine whether target Wwox ablation in the mammary gland go to enhanced mammary tumorigenesis and increases metastasis. The aim study will provide novel data on the mechanistic basis of bone metastasis development and identify likely novel target for therapeutic treatment. PUBLIC HEALTH RELEVANCE:
edijg bone metastases and arsociated osteolytic dmsease. Zim 4: To aetermine whether targeted Wxox qblatuon in the mammary glavd leads no enhancwd memmary tumorigenxais and increzdes kxtastasis. The ptoposed studhes will provige nlvel information on the mechanistic basis pf bone metastasys dtvejopmsnt and identify potential novel tzrgets hor therapeutic intervention. PUBLIC HEALTJ REPEVANCE:
eding bone metastases and associated osteolytic disease. To whether targeted ablation in the mammary and increases metastasis. proposed studies will novel information on the mechanistic basis bone metastasis development and identify potential novel targets for therapeutic intervention. PUBLIC HEALTH
eding bone metastases and assOciated ostEolytIc dIseAsE. Aim 4: to deTermine whether TArgeTed Wwox ablation in the maMmary GlANd leADs To enhAnced maMMaRY TumOrIgEneSiS AnD incrEasEs metasTasis. The prOpoSeD studies will PRoVide novel iNfoRmation on the MecHanistIc BasIS of boNe mEtastAsis deVElopmeNt and idenTiFY potenTIal noveL TArGets For therapeutic intERvENtion. PUBLIC HEAlTH RELeVanCe:
eding bone metastases andassociated  oste oly tic  d isea se.Aim 4: To dete r mine  whether targeted Wwox  abla ti o n in th e mam mary gl a nd l ead sto  en ha n ce d mam mar y tumor igenesis a ndin creases meta s ta sis. The p rop osed studies  wi ll pro vi den ovelinf ormat ion on the me chanistic  b a sis of bone me t a st asis  development andi de n tify potential  novel  t a rg e t s f ortherapeuti cinter v ention. PU B L I C H E ALTH RELEVANC E:
eding bone_metastases and_associated osteolytic disease. Aim_4: To_determine_whether targeted_Wwox_ablation in the_mammary gland leads_to enhanced mammary tumorigenesis_and increases metastasis._The_proposed studies will provide novel information on the mechanistic basis of bone metastasis development_and_identify potential_novel_targets_for therapeutic intervention. PUBLIC HEALTH_RELEVANCE: