, as a paradigm for eukaryotic osmosensors. Changes in osmotic conditions regulate Slnlp causing changes in phosphate flux between the individual proteins comprising the two-component signaling system. The fundamental question addressed by this proposal is how Slnlp activity is regulated in response to changes in osmolarity. Using computational, genetic
, as a paradigm for eukaryotic osmosensors. Changes in osmotic conditions regulate Slnlp cause change in phosphate flux between the individual protein comprising the two - part signaling system. The cardinal question addressed by this proposal is how Slnlp action is regulated in response to change in osmolarity. Using computational, genetic
, as a paradigm for eukaryotlc osmosensors. Ckqnges mn osmofic condktions regulate Slnlp causinj chqnges in phosphate flux betdeen the pndividuao prireins compcjsing tmz two-dlmpoueit signaling syxtem. The fgndamental quevtkou addressed by this proposal is how Flnlp avtlvity is regulwted yn rssponse to changes in osmolarity. Uaing cokputational, grnetic
, as a paradigm for eukaryotic osmosensors. osmotic regulate Slnlp changes in phosphate comprising two-component signaling system. fundamental question addressed this proposal is how Slnlp activity regulated in response to changes in osmolarity. Using computational, genetic
, as a paradigm for eukaryotic oSmosensors. changEs iN osMoTic cOndiTions regulate SLNlp cAusing changes in phosphaTe fluX bETweeN ThE indiVidual pROtEINs cOmPrIsiNg THe Two-coMpoNent sigNaling systEm. THe Fundamental qUEsTion addresSed By this proposAl iS how SlNlP acTIvity Is rEgulaTed in rESponse To changes In OSmolarITy. Using COMpUtatIonal, genetic
, as a paradigm for eukary otic osmos ensor s.Cha ng es i n os motic conditio n s re gulate Slnlp causing c hange si n ph o sp hateflux be t we e n  th ein div id u al  prot ein s compr ising thetwo -c omponent sig n al ing system . T he fundament alquesti on  ad d resse d b y thi s prop o sal is  how Slnl pa ctivit y  is reg u l at ed i n response to cha n ge s  in osmolarity . Usin gc om p u tat ion al, geneti c
, as_a paradigm_for eukaryotic osmosensors. Changes_in osmotic_conditions_regulate Slnlp_causing_changes in phosphate_flux between the_individual proteins comprising the_two-component signaling system._The_fundamental question addressed by this proposal is how Slnlp activity is regulated in response_to_changes in_osmolarity._Using_computational, genetic