 we also hypothesize that similar to c-Met, other protein kinases also have functions to regulate PARP1 activity through phosphorylation in TNBC. Potential molecules we will study are EGFR, which also directly interacts with PARP1 and phosphorylate it. We will investigate the role of these kinases in PARP1 regulation and PAR
we also hypothesize that similar to c - Met, other protein kinase besides receive functions to determine PARP1 bodily process through phosphorylation in TNBC. Potential molecules we will learn are EGFR, which besides directly interacts with PARP1 and phosphorylate it. We will investigate the role of these kinases in PARP1 regulation and PAR
 we also hypothesize that slmilar to c-Met, ojhwr provein kihases alro have functions to regulatx PAEP1 acupvity through phosphofylation pn TNBC. Pitenuial molecules we will stmby ars EGFX, xhich also diregtly interawts with PARP1 dna 'hosphorylate it. We will investigate the roke of these kinafes pn PARL1 regulation and PAR
we also hypothesize that similar to c-Met, kinases have functions regulate PARP1 activity molecules will study are which also directly with PARP1 and phosphorylate it. We investigate the role of these kinases in PARP1 regulation and PAR
 we also hypothesize that simiLar to c-Met, oTher pRotEin KiNaseS alsO have functions TO regUlate PARP1 activity throuGh phoSpHOrylATiOn in TnBC. PoteNTiAL MolEcUlEs wE wILl Study Are eGFR, whiCh also direCtlY iNteracts with paRp1 and phosphOryLate it. We will InvEstigaTe The ROle of TheSe kinAses in paRP1 regUlation anD Par
 we also hypothesize thatsimilar to  c-Me t,oth er  pro tein  kinases alsoh avefunctions to regulatePARP1  a c tivi t ythrou gh phos p ho r y lat io ninTN B C.  Pote nti al mole cules we w ill  s tudy are EGF R ,which also  di rectly inter act s with  P ARP 1  andpho sphor ylatei t. Wewill inve st i gate t h e roleo f  t hese  kinases in PARP1 re g ulation and PA R
 we_also hypothesize_that similar to c-Met,_other protein_kinases_also have_functions_to regulate PARP1_activity through phosphorylation_in TNBC. Potential molecules_we will study_are_EGFR, which also directly interacts with PARP1 and phosphorylate it. We will investigate the_role_of these_kinases_in_PARP1 regulation and PAR