 macrophages are sensitized to inflammatory stimuli, including LPS. However, the molecular mediators that may contribute to age-related immune disorders remain ambiguous and largely undefined. Here, we propose to employ a systems-based approach, which will integrate a series of functional genomics analyses, to identify novel molecular factors that contribute to increased LPS
macrophages are sensitized to inflammatory stimuli, including LPS. However, the molecular mediator that may lend to age - related immune disorder stay ambiguous and largely undefined. Here, we propose to hire a system - establish approach, which will integrate a serial of functional genomics analyses, to identify novel molecular gene that contribute to increased LPS
 mafrophages are sensitized to inflammatori wtimulm, inclusing LPS. However, the molecular mediavors that may contribute to age-felated ilmune diwordtrs remain ambiguous and largelg undzfmned. Here, we prppose to ekploy a systemv-bxszd approach, which will integrate a sqries og vunctional genjmicx anamjsts, to identify novel molecular fadtors tiat contribute yo increased LPS
macrophages are sensitized to inflammatory stimuli, including the mediators that contribute to age-related largely Here, we propose employ a systems-based which will integrate a series of genomics analyses, to identify novel molecular factors that contribute to increased LPS
 macrophages are sensitized tO inflammatOry stImuLi, iNcLudiNg LPs. However, the molECulaR mediators that may contrIbute To AGe-reLAtEd immUne disoRDeRS RemAiN aMbiGuOUs And laRgeLy undefIned. Here, we ProPoSe to employ a sYStEms-based apProAch, which will IntEgrate A sEriES of fuNctIonal GenomiCS analySes, to idenTiFY novel MOleculaR FAcTors That contribute to iNCrEAsed LPS
 macrophages are sensitize d to infla mmato rysti mu li,incl uding LPS. How e ver,  the molecular mediato rs th at mayc on tribu te to a g e- r e lat ed  i mmu ne di sorde rsremainambiguousand  l argely undef i ne d. Here, w e p ropose to em plo y a sy st ems - based  ap proac h, whi c h will  integrat ea  serie s  of fun c t io nalgenomics analyses ,  t o  identify nove l mole cu l ar f act ors  that cont ri butet o incre a se d L PS
 macrophages_are sensitized_to inflammatory stimuli, including_LPS. However,_the_molecular mediators_that_may contribute to_age-related immune disorders_remain ambiguous and largely_undefined. Here, we_propose_to employ a systems-based approach, which will integrate a series of functional genomics analyses,_to_identify novel_molecular_factors_that contribute to increased LPS