ating epithelial cells, alterations in basement membrane composition, and aberrant localization of cell surface proteins. These cellular properties are consistent with a reversion of the renal epithelial cell to a more embryonic phenotype. Thus, genes regulating the differentiation and proliferation of the normal renal epithelium may be aberrantly affected in PKD and may directly contribute to
ating epithelial cells, alterations in basement membrane composition, and aberrant localization of cellular telephone open proteins. These cellular properties are reproducible with a regression of the renal epithelial cell to a more embryonic phenotype. therefore, genes regulating the differentiation and proliferation of the normal nephritic epithelium may be aberrantly involve in PKD and may directly put up to
atijg epithelial cells, altevations in basemgnr membcane cojpositiov, and aberrant localization lf cell surface proteins. Thesd cellulag propertues ere consistent wmfh a reyzrsioh of chx renal epithellal cell to a more embryotiz 'henotype. Thus, genes regulating the qifferemtlation and projifegaeion of the normal renal epithelium mag be abtrrantly affected on PKD and may directly cojtrihute to
ating epithelial cells, alterations in basement membrane aberrant of cell proteins. These cellular reversion the renal epithelial to a more phenotype. Thus, genes regulating the differentiation proliferation of the normal renal epithelium may be aberrantly affected in PKD and directly contribute to
ating epithelial cells, alterAtions in baSemenT meMbrAnE comPosiTion, and aberranT LocaLization of cell surface pRoteiNs. tHese CElLular PropertIEs ARE coNsIsTenT wITh A reveRsiOn of the Renal epithEliAl Cell to a more eMBrYonic phenoTypE. Thus, genes reGulAting tHe DifFErentIatIon anD proliFEratioN of the norMaL Renal ePItheliuM MAy Be abErrantly affected iN pKd And may directly ContriBuTE tO
ating epithelial cells, al terationsin ba sem ent  m embr anecomposition, a n d ab errant localization of  cell  s u rfac e  p rotei ns. The s ec e llu la rpro pe r ti es ar e c onsiste nt with arev er sion of ther en al epithel ial  cell to a m ore  embry on icp henot ype . Thu s, gen e s regu lating th ed iffere n tiation a nd  pro liferation of the no r mal renal epit helium  m a yb e  ab err antly affe ct ed in PKD and ma y d ire c tly contribut e to
ating epithelial_cells, alterations_in basement membrane composition,_and aberrant_localization_of cell_surface_proteins. These cellular_properties are consistent_with a reversion of_the renal epithelial_cell_to a more embryonic phenotype. Thus, genes regulating the differentiation and proliferation of the_normal_renal epithelium_may_be_aberrantly affected in PKD and_may directly contribute to