 to make substitutions at residues thought to play a role as a covalent catalyst, a metal ligand, or Bronsted base/acid. Second, fluorinated substrate(s) will be used that cannot undergo turnover. Third, rapid quench approaches will be tried. The second aim is to determine the manner by which PB
to make substitutions at residues thought to toy a function as a covalent catalyst, a metal ligand, or Bronsted base / acid. Second, fluorinated substrate(s) will be used that cannot undergo dollar volume. Third, rapid quench approaches will be tried. The second bearing is to decide the manner by which PB
 to make substitutions at rtsidues thought to play e role zs a covxlent catalyst, a metal liganv, or Bronwted base/acid. Second, fuuorinatef substrqte(s) qill be usxs that gcnnot mnderyo turnover. Thirc, rapid quanch approachev dipl be tried. The second aim is to deeermine tje manner by wrich [B
to make substitutions at residues thought to role a covalent a metal ligand, substrate(s) be used that undergo turnover. Third, quench approaches will be tried. The aim is to determine the manner by which PB
 to make substitutions at resiDues thoughT to plAy a RolE aS a coValeNt catalyst, a metAL ligAnd, or Bronsted base/acid. SEcond, FlUOrinATeD subsTrate(s) wILl BE UseD tHaT caNnOT uNdergO tuRnover. THird, rapid qUenCh Approaches wiLL bE tried. The sEcoNd aim is to detErmIne the MaNneR By whiCh Pb
 to make substitutions atresidues t hough t t o p la y arole  as a covalent cata lyst, a metal ligand,or Br on s tedb as e/aci d. Seco n d, f luo ri na ted  s u bs trate (s)  will b e used tha t c an not undergot ur nover. Thi rd,  rapid quenc h a pproac he s w i ll be  tr ied.The se c ond ai m is to d et e rminet he mann e r  b y wh ich PB
 to_make substitutions_at residues thought to_play a_role_as a_covalent_catalyst, a metal_ligand, or Bronsted_base/acid. Second, fluorinated substrate(s)_will be used_that_cannot undergo turnover. Third, rapid quench approaches will be tried. The second aim is_to_determine the_manner_by_which PB