 multiple metastatic lesions, patients typically die within one to two years. Gap: Treatment of brain metastases is primarily palliative due to limited curative effectiveness of radiation, surger, and poor delivery of chemotherapy across the blood-brain barrier (BBB). This proposal focuses on preventing metastasis seeding and initial growth in brain using preclinical models
multiple metastatic lesions, patients typically die within one to two years. Gap: Treatment of mind metastasis is primarily palliative due to circumscribed curative effectiveness of radiotherapy, surger, and poor delivery of chemotherapy across the rake - brain barrier (BBB). This proposal concentrate on preventing metastasis seeding and initial growth in genius using preclinical models
 muptiple metastatic lesionr, patients typieqlly dme withjn one tu two years. Gap: Treatment of beain netastases is primarilh palliatpve due ti linuted curatmbe effegcivensds oy cadiation, surget, and poor dalivery of chekoghzrapy across the blood-brain barrier (FBB). Thix oroposal focusgs on [revsnting metastasis seeding and initjal groxth in brain usong preclinical models
multiple metastatic lesions, patients typically die within two Gap: Treatment brain metastases is curative of radiation, surger, poor delivery of across the blood-brain barrier (BBB). This focuses on preventing metastasis seeding and initial growth in brain using preclinical models
 multiple metastatic lesions, Patients tyPicalLy dIe wItHin oNe to Two years. Gap: TreATmenT of brain metastases is prImariLy PAlliATiVe due To limitED cURAtiVe EfFecTiVEnEss of RadIation, sUrger, and poOr dElIvery of chemoTHeRapy across The Blood-brain baRriEr (BBB). THiS prOPosal FocUses oN preveNTing meTastasis sEeDIng and INitial gROWtH in bRain using precliniCAl MOdels
 multiple metastatic lesio ns, patien ts ty pic all ydiewith in one to twoy ears . Gap: Treatment of br ain m et a stas e sis pr imarily pa l l iat iv edue  t o  l imite d c urative  effective nes sof radiation ,  s urger, and  po or deliveryofchemot he rap y  acro ssthe b lood-b r ain ba rrier (BB B) .  Thisp roposal f oc uses  on preventing me t as t asis seeding a nd ini ti a lg r owt h i n brain us in g pre c linical mo d e l s
 multiple_metastatic lesions,_patients typically die within_one to_two_years. Gap:_Treatment_of brain metastases_is primarily palliative_due to limited curative_effectiveness of radiation,_surger,_and poor delivery of chemotherapy across the blood-brain barrier (BBB). This proposal focuses on_preventing_metastasis seeding_and_initial_growth in brain using preclinical_models