 studies revealed that a synthetic single-stranded oligonucleotide composed of the CRE sequence, which self-hybridizes to form a duplex/hairpin, can penetrate into cells, compete with CRE enhancers for binding transcription factors and specifically interfere with CRE- and Ap-1-directed transcription in vivo. This oligonucleotide restrained tumor cell proliferation
studies revealed that a synthetic single - stranded oligonucleotide write of the CRE succession, which self - hybridizes to form a duplex / hairpin, can permeate into cell, compete with CRE enhancers for binding recording agent and specifically interfere with CRE- and Ap-1 - direct transcription in vivo. This oligonucleotide restrained tumor cellular telephone proliferation
 stkdies revealed that a sykthetic single-sttabded onigonudleotide composed of the CRE sequencx, whuch stjf-hybridizes to fofm a duplvx/hairpin, can penetrate mhto cells, comlcte wnti CRE enhancers for binditg transcriptimn fcctors and specifically interfere wieh CRE- snf Ap-1-directed ttanscgi[tioh in vivo. This oligonucleotide resfrained tumor cell ptoliferation
studies revealed that a synthetic single-stranded oligonucleotide the sequence, which to form a compete CRE enhancers for transcription factors and interfere with CRE- and Ap-1-directed transcription vivo. This oligonucleotide restrained tumor cell proliferation
 studies revealed that a synthEtic single-StranDed OliGoNuclEotiDe composed of thE cRE sEquence, which self-hybridIzes tO fORm a dUPlEx/haiRpin, can PEnETRatE iNtO ceLlS, CoMpete WitH CRE enhAncers for bIndInG transcriptiON fActors and sPecIfically inteRfeRe with cRe- anD ap-1-dirEctEd traNscripTIon in vIvo. This olIgONucleoTIde restRAInEd tuMor cell proliferatIOn
 studies revealed that a s ynthetic s ingle -st ran de d ol igon ucleotide comp o sedof the CRE sequence, w hichse l f-hy b ri dizes  to for m  a d upl ex /h air pi n ,can p ene trate i nto cells,  co mp ete with CRE en hancers fo r b inding trans cri ptionfa cto r s and  sp ecifi callyi nterfe re with C RE -  and A p -1-dire c t ed  tra nscription in viv o .T his oligonucle otidere s tr a i ned  tu mor cell p ro lifer a tion
 studies_revealed that_a synthetic single-stranded oligonucleotide_composed of_the_CRE sequence,_which_self-hybridizes to form_a duplex/hairpin, can_penetrate into cells, compete_with CRE enhancers_for_binding transcription factors and specifically interfere with CRE- and Ap-1-directed transcription in vivo. This_oligonucleotide_restrained tumor_cell_proliferation