 HSCs and progenitors that can repopulate the recipient's hematopoietic system is estimated at best 1 in 2-5x106 among Cdx4-HoxB4 induced ES derived cells (3). Constitutive HoxB4 expression in transplanted cells could also be problematic. The overall objective is to robustly generate
HSCs and progenitors that can repopulate the recipient's hematopoietic system is estimated at well 1 in 2 - 5x106 among Cdx4 - HoxB4 induce ES derived cells (3). Constitutive HoxB4 formulation in transplanted cells could besides be problematic. The overall objective is to robustly generate
 HSFs and progenitors that gan repopulate tkw reci'ient's gematopoketic system is estimated at bwst 1 un 2-5x106 among Cdx4-HoxB4 indjced ES dvrived ceols (3). Xonstitutits HoxB4 crpresalon iu vransplanted cekls could dlso be problekagie. The overall objective is to robustjy genetahe
HSCs and progenitors that can repopulate the system estimated at 1 in 2-5x106 cells Constitutive HoxB4 expression transplanted cells could be problematic. The overall objective is robustly generate
 HSCs and progenitors that can Repopulate The reCipIenT's HemaTopoIetic system is eSTimaTed at best 1 in 2-5x106 among Cdx4-HoXB4 indUcED ES dERiVed ceLls (3). ConsTItUTIve hoXB4 ExpReSSiOn in tRanSplanteD cells coulD alSo Be problematiC. thE overall obJecTive is to robuStlY generAtE
 HSCs and progenitors that  can repop ulate  th e r ec ipie nt's  hematopoietic syst em is estimated at bes t 1 i n2 -5x1 0 6among  Cdx4-H o xB 4 ind uc ed  ES  d e ri ved c ell s (3).Constituti veHo xB4 expressi o nin transpl ant ed cells cou ldalso b epro b lemat ic.  Theoveral l  objec tive is t or obustl y  genera t e 
 HSCs_and progenitors_that can repopulate the_recipient's hematopoietic_system_is estimated_at_best 1 in_2-5x106 among Cdx4-HoxB4_induced ES derived cells_(3). Constitutive HoxB4_expression_in transplanted cells could also be problematic. The overall objective is to robustly generate