 will test the hypothesis that mutant cardiac troponin and different tropomyosin variants perturb muscle regulation by causing an imbalance in tropomyosin's position that alters the regulatory state of thin filaments. (3) We will assess the regulatory role of thin filament-linked caldesmon and calponin in defining tropomyosin position
will test the hypothesis that mutant cardiac troponin and different tropomyosin variants perturb muscle rule by cause an imbalance in tropomyosin's position that alter the regulative state of thin filaments. (3) We will measure the regulatory role of slender filament - linked caldesmon and calponin in define tropomyosin position
 wipl test the hypothesis tmat mutant cardicx tropmnin ahd diffefent tropomyosin variants pecturv musxle regulation by causkng an imhalance un tcopomyosin's posivjon thab altsvs thz cegulatory statg of thin finaments. (3) We winl adsess the regulatory role of thin fylament-kijked caldesmon and salpknin in defining tropomyosin positjon
will test the hypothesis that mutant cardiac different variants perturb regulation by causing that the regulatory state thin filaments. (3) will assess the regulatory role of filament-linked caldesmon and calponin in defining tropomyosin position
 will test the hypothesis that Mutant cardIac trOpoNin AnD difFereNt tropomyosin vARianTs perturb muscle regulatIon by CaUSing AN iMbalaNce in trOPoMYOsiN's PoSitIoN ThAt altErs The reguLatory statE of ThIn filaments. (3) WE WiLl assess thE reGulatory role Of tHin filAmEnt-LInked CalDesmoN and caLPonin iN defining TrOPomyosIN positiON
 will test the hypothesisthat mutan t car dia c t ro poni n an d different tr o pomy osin variants perturbmuscl er egul a ti on by  causin g  a n imb al an cein tr opomy osi n's pos ition that  al te rs the regul a to ry state o f t hin filament s.(3) We  w ill asses s t he re gulato r y role  of thinfi l ament- l inked c a l de smon  and calponin ind ef i ning tropomyos in pos it i on 
 will_test the_hypothesis that mutant cardiac_troponin and_different_tropomyosin variants_perturb_muscle regulation by_causing an imbalance_in tropomyosin's position that_alters the regulatory_state_of thin filaments. (3) We will assess the regulatory role of thin filament-linked caldesmon_and_calponin in_defining_tropomyosin_position