), mitochondrial permeability transition (MPT), depolarization and swelling, release of cytochrome c, and activation of both necrosis and caspase-dependent apoptosis in tumor cells. However, PC 4 and a recently synthesized PC 4 derivative PC 181 also localize to endoplasmic reticulum (ER) and lysosomes. We hypothesize that damage to
), mitochondrial permeability transition (MPT), depolarization and swelling, release of cytochrome c, and energizing of both necrosis and caspase - pendent apoptosis in tumor cells. However, PC 4 and a recently synthesize personal computer 4 derivative PC 181 also localize to endoplasmic reticulum (ER) and lysosome. We speculate that damage to
), mihochondrial permeability transition (MPT), depolacizatioh and swdlling, release of cytochrome c, and qctivation of both necfosis and caspase-eepeident apoptosis mh tumor cells. Mowevzr, PC 4 and a recgntly synthevized PC 4 derieagire PC 181 also localize to endoplasmic weticulim (ER) and lysosoies. Eq hylothesize that damage to
), mitochondrial permeability transition (MPT), depolarization and of c, and of both necrosis cells. PC 4 and recently synthesized PC derivative PC 181 also localize to reticulum (ER) and lysosomes. We hypothesize that damage to
), mitochondrial permeability Transition (mPT), dePolAriZaTion And sWelling, release OF cytOchrome c, and activation oF both NeCRosiS AnD caspAse-depeNDeNT ApoPtOsIs iN tUMoR cellS. HoWever, PC 4 And a recentLy sYnThesized PC 4 deRIvAtive PC 181 alsO loCalize to endoPlaSmic reTiCulUM (ER) anD lySosomEs. We hyPOthesiZe that damAgE To
), mitochondrial permeabil ity transi tion(MP T),  d epol ariz ation and swel l ing,  release of cytochrome  c, a nd acti v at ion o f bothn ec r o sis  a nd  ca sp a se -depe nde nt apop tosis in t umo rcells. Howev e r,  PC 4 anda r ecently synt hes ized P C4 d e rivat ive  PC 1 81 als o  local ize to en do p lasmic reticul u m  ( ER)and lysosomes. We hy p othesize thatdamage  t o 
), mitochondrial_permeability transition_(MPT), depolarization and swelling,_release of_cytochrome_c, and_activation_of both necrosis_and caspase-dependent apoptosis_in tumor cells. However,_PC 4 and_a_recently synthesized PC 4 derivative PC 181 also localize to endoplasmic reticulum (ER) and_lysosomes._We hypothesize_that_damage_to