 Further research and development of these Fc mutants should lead to therapeutic antibodies with increased capacity to trigger antibody dependent cytotoxic reactions against tumor cells. This proposal describes an experimental paradigm to identify Fc mutations, characterize the mutations in functional assays, and ultimately test therapeutic antibodies harboring the best Fc mutations in animal model studies. DESCRIPTION: Abstract Tra
Further research and development of these Fc mutants should lead to curative antibody with increase capacity to trip antibody dependent cytotoxic reaction against tumor cells. This marriage proposal describes an experimental paradigm to identify Fc mutant, characterize the mutations in running assays, and ultimately test therapeutic antibodies harbor the best Fc mutations in animal model studies. DESCRIPTION: Abstract Tra
 Fugther research and develupment of these Fc mutents shkuld leaa to therapeutic antibodies xith incrtcsed capacity to trieger antihody depwndeit cytotoxic rearfions ancinst bumor rells. This proppsal descrhbes an experikevtcl paradigm to identify Fc mutations, characyegize the mutatyons yn fhnctional assays, and ultimately teat therepeutic antibodoes harboring the best Fc lutahions in animal mofel studies. DESSEIPTION: Abstfact Tra
Further research and development of these Fc lead therapeutic antibodies increased capacity to against cells. This proposal an experimental paradigm identify Fc mutations, characterize the mutations functional assays, and ultimately test therapeutic antibodies harboring the best Fc mutations in model studies. DESCRIPTION: Abstract Tra
 Further research and developMent of thesE Fc muTanTs sHoUld lEad tO therapeutic anTIbodIes with increased capaciTy to tRiGGer aNTiBody dEpendenT CyTOToxIc ReActIoNS aGainsT tuMor cellS. This propoSal DeScribes an expERiMental paraDigM to identify FC muTationS, cHarACteriZe tHe mutAtions IN functIonal assaYs, ANd ultiMAtely teST ThErapEutic antibodies haRBoRIng the best Fc muTationS iN AnIMAl mOdeL studies. DEsCrIPTIon: AbstraCT TRA
 Further research and deve lopment of  thes e F c m ut ants  sho uld lead to th e rape utic antibodies with i ncrea se d  cap a ci ty to  trigge r  a n t ibo dy  d epe nd e nt  cyto tox ic reac tions agai nst  t umor cells.T hi s proposal  de scribes an e xpe riment al  pa r adigm  to  iden tify F c  mutat ions, cha ra c terize the mut a t io ns i n functional assa y s, and ultimately  testth e ra p e uti c a ntibodiesha rbori n g the b e st F c  mu t ations in ani mal model s t udi es. DE SC RIP T ION: A bstra ct Tra 
 Further_research and_development of these Fc_mutants should_lead_to therapeutic_antibodies_with increased capacity_to trigger antibody_dependent cytotoxic reactions against_tumor cells. This_proposal_describes an experimental paradigm to identify Fc mutations, characterize the mutations in functional assays,_and_ultimately test_therapeutic_antibodies_harboring the best Fc mutations_in animal model studies. DESCRIPTION:_Abstract Tra