 dose for two weeks. The target AUC is considered to have been achieved if the dose was tolerated and at least 4 of 6 subjects reached the target AUC. Enrollment of subjects will be ongoing and those begun on a given starting dose will continue on that dose until individual subject dose adjustments are needed according to their individual pharmac
dose for two weeks. The target AUC is consider to have been achieve if the dose was tolerated and at least 4 of 6 discipline reach the target AUC. registration of topic will be ongoing and those begun on a contribute starting dose will cover on that dose until individual subject acid adaptation are needed harmonize to their individual pharmac
 dode for two weeks. The tarnet AUC is consibwred tm have been acfieved if the dose was tolereted and qt least 4 of 6 subjects reached nhe targer AUR. Enrollment of subjects will gc ongmmng and those bggun on a gieen starting dmsd cill continue on that dose until indyvidual skbject dose adtustkqnts are needed according to their indjvidual pharmac
dose for two weeks. The target AUC to been achieved the dose was of subjects reached the AUC. Enrollment of will be ongoing and those begun a given starting dose will continue on that dose until individual subject dose are needed according to their individual pharmac
 dose for two weeks. The target AuC is considEred tO haVe bEeN achIeveD if the dose was tOLeraTed and at least 4 of 6 subjectS reacHeD The tARgEt AUC. enrollmENt OF SubJeCtS wiLl BE oNgoinG anD those bEgun on a givEn sTaRting dose wilL CoNtinue on thAt dOse until indiVidUal subJeCt dOSe adjUstMents Are neeDEd accoRding to thEiR IndiviDUal pharMAC
 dose for two weeks. The t arget AUCis co nsi der ed  tohave  been achieved if t he dose was toleratedand a tl east 4of 6subject s  r e a che dth e t ar g et  AUC.  En rollmen t of subje cts  w ill be ongoi n gand thosebeg un on a give n s tartin gdos e  will  co ntinu e on t h at dos e until i nd i vidual subject d os e ad justments are nee d ed according to t heir i nd i vi d u alpha rmac
 dose_for two_weeks. The target AUC_is considered_to_have been_achieved_if the dose_was tolerated and_at least 4 of_6 subjects reached_the_target AUC. Enrollment of subjects will be ongoing and those begun on a given_starting_dose will_continue_on_that dose until individual subject_dose adjustments are needed according_to their_individual pharmac