) To increase, through iterative optimizations selectivity, potency and drug-likeness of selected LF inhibitors. (II) To perform in vitro and in cell toxicity studies to refine hits and identify drug-like inhibitor(s) of LF for subsequent in vivo studies. (Ill) To perform in vivo efficacy evaluations and
) To increase, through iterative optimizations selectivity, potency and drug - likeness of selected LF inhibitors. (II) To do in vitro and in cellular telephone perniciousness studies to refine hits and name drug - like inhibitor(s) of LF for subsequent in vivo studies. (Ill) To perform in vivo efficacy evaluations and
) To increase, through iteratlve optimizations selecvivity, lotency xnd drug-likeness of selected LD inhubitors. (II) To perform kn vitro wnd in cwll uoxicity studies vk refinc hita and mdentify drug-lile inhibitmr(s) of LF for vucszquent in vivo studies. (Ill) To perfori in vifo efficacy evaloatiomf ans
) To increase, through iterative optimizations selectivity, drug-likeness selected LF (II) To perform toxicity to refine hits identify drug-like inhibitor(s) LF for subsequent in vivo studies. To perform in vivo efficacy evaluations and
) To increase, through iterativE optimizatIons sEleCtiViTy, poTencY and drug-likeneSS of sElected LF inhibitors. (II) TO perfOrM In viTRo And in Cell toxICiTY StuDiEs To rEfINe Hits aNd iDentify Drug-like inHibItOr(s) of LF for suBSeQuent in vivO stUdies. (Ill) To peRfoRm in viVo EffICacy eValUatioNs and
) To increase, through ite rative opt imiza tio nsse lect ivit y, potency and drug -likeness of selectedLF in hi b itor s .(II)To perf o rm i n v it ro  an di ncelltox icity s tudies toref in e hits and i d en tify drug- lik e inhibitor( s)of LFfo r s u bsequ ent  in v ivo st u dies.(Ill) Tope r form i n  vivo e f f ic acyevaluations and
) To_increase, through_iterative optimizations selectivity, potency_and drug-likeness_of_selected LF_inhibitors._(II) To perform_in vitro and_in cell toxicity studies_to refine hits_and_identify drug-like inhibitor(s) of LF for subsequent in vivo studies. (Ill) To perform in_vivo_efficacy evaluations_and