. In carrying out this proposal, we plan to take advantage of our studies involving the characterization of normal epithelial keratin glycosylation and phosphorylation. For example, we recently showed that keratins 8 and 18 are O-linked glycoproteins with glycosylation sites consisting of single N-acetylglucosamine (GlcNAc
. In carrying out this proposal, we plan to take advantage of our report imply the characterization of normal epithelial keratin glycosylation and phosphorylation. For example, we recently showed that keratins 8 and 18 are O - connect glycoproteins with glycosylation sites consist of unmarried N - acetylglucosamine (GlcNAc
. In carrying out this proporal, we plan to jaje adventage kf our sgudies involving the charactxrizqtion of normal epithelial yeratin gpycosylarion qnd phosphorylatiok. For cxampnx, we recently smowed that neratins 8 and 18 afe O-linked glycoproteins with glycosyjation xihes consisting of xyngls N-acetylglucosamine (GlcNAc
. In carrying out this proposal, we take of our involving the characterization and For example, we showed that keratins and 18 are O-linked glycoproteins with sites consisting of single N-acetylglucosamine (GlcNAc
. In carrying out this proposal, We plan to taKe advAntAge Of Our sTudiEs involving the CHaraCterization of normal epiTheliAl KEratIN gLycosYlation ANd PHOspHoRyLatIoN. foR examPle, We recenTly showed tHat KeRatins 8 and 18 are o-LiNked glycopRotEins with glycOsyLation SiTes COnsisTinG of siNgle N-aCEtylglUcosamine (glCnAc
. In carrying out this pro posal, weplantotak eadva ntag e of our studi e s in volving the characteri zatio no f no r ma l epi thelial ke r a tin  g ly cos yl a ti on an d p hosphor ylation. F orex ample, we re c en tly showed  th at keratins8 a nd 18ar e O - linke d g lycop rotein s  withglycosyla ti o n site s  consis t i ng  ofsingle N-acetylgl u co s amine (GlcNAc
. In_carrying out_this proposal, we plan_to take_advantage_of our_studies_involving the characterization_of normal epithelial_keratin glycosylation and phosphorylation._For example, we_recently_showed that keratins 8 and 18 are O-linked glycoproteins with glycosylation sites consisting of_single_N-acetylglucosamine (GlcNAc