 MIP-1alpha showed improved neurologic status and a longer lifespan. The results indicate that the pathogenesis of Sandhoff disease involves an increase in MIP-1alpha that induces monocytes to infiltrate the brain, expand the activated macrophage/microglial population, and trigger apoptosis of neurons, resulting in a rapid neurodegenerative
MIP-1alpha showed improved neurologic status and a long life. The results indicate that the pathogenesis of Sandhoff disease imply an addition in MIP-1alpha that induces monocytes to infiltrate the brain, boom the activated macrophage / microglial population, and trigger apoptosis of nerve cell, result in a rapid neurodegenerative
 MIO-1alpha showed improved nturologic status cbd a lmnger mifespan. The results indicate that tie pqthogtuesis of Sandhoff direase invllves an inccease in MIP-1alphe that ikbuces lonoeyves to infiltraje the brain, expand the acdixaced macrophage/microglial population, wnd tribgfr apoptosis os nelrjns, dvsmlting in a rapid neurodegeneratjve
MIP-1alpha showed improved neurologic status and a The indicate that pathogenesis of Sandhoff MIP-1alpha induces monocytes to the brain, expand activated macrophage/microglial population, and trigger apoptosis neurons, resulting in a rapid neurodegenerative
 MIP-1alpha showed improved neuRologic staTus anD a lOngEr LifeSpan. the results indiCAte tHat the pathogenesis of SaNdhofF dISeasE InVolveS an incrEAsE IN MIp-1aLpHa tHaT InDuces MonOcytes tO infiltratE thE bRain, expand thE AcTivated macRopHage/microgliAl pOpulatIoN, anD TriggEr aPoptoSis of nEUrons, rEsulting iN a RApid neURodegenERAtIve
 MIP-1alpha showed improve d neurolog ic st atu s a nd  a l onge r lifespan. Th e  res ults indicate that the  path og e nesi s  o f San dhoff d i se a s e i nv ol ves  a n  i ncrea sein MIP- 1alpha tha t i nd uces monocyt e sto infiltr ate  the brain,exp and th eact i vated  ma croph age/mi c roglia l populat io n , andt riggera p op tosi s of neurons, res u lt i ng in a rapidneurod eg e ne r a tiv e
 MIP-1alpha_showed improved_neurologic status and a_longer lifespan._The_results indicate_that_the pathogenesis of_Sandhoff disease involves_an increase in MIP-1alpha_that induces monocytes_to_infiltrate the brain, expand the activated macrophage/microglial population, and trigger apoptosis of neurons, resulting_in_a rapid_neurodegenerative