 effectively treat bone disease in MPS VII, it will be necessary to both normalize GAG turnover and activate requisite osteogenic signaling pathways in epiphyseal cartilage. In Aim 1 we will define temporal and spatial relationships between GAG accumulation and epiphyseal chondrocyte differentiation potential at key stages of bone disease
effectively treat bone disease in MPS VII, it will be necessary to both normalize GAG turnover and trip needed osteogenic bespeak pathways in epiphyseal cartilage. In purpose 1 we will specify temporal and spatial relationships between GAG collection and epiphyseal chondrocyte specialization potential at key stages of bone disease
 efvectively treat bone distase in MPS VII, ij qill bx necesaary to coth normalize GAG turnover end qctivqte requisite osteogenkc signalpng pathwqys mn epiphyseal cacfilage. Lu Aim 1 we ciol define temppral and s[atial relatiotsfi's between GAG accumulation and epipryseal vhlndrocyte diffgrentpaeion iouential at key stages of bone dissase
effectively treat bone disease in MPS VII, be to both GAG turnover and in cartilage. In Aim we will define and spatial relationships between GAG accumulation epiphyseal chondrocyte differentiation potential at key stages of bone disease
 effectively treat bone diseaSe in MPS VII, It wilL be NecEsSary To boTh normalize GAG TUrnoVer and activate requisitE osteOgENic sIGnAling PathwayS In EPIphYsEaL caRtILaGe. In AIm 1 wE will deFine temporAl aNd Spatial relatIOnShips betweEn GaG accumulatiOn aNd epipHySeaL ChondRocYte diFferenTIation Potential At KEy stagES of bone DISeAse
 effectively treat bone di sease in M PS VI I,itwi ll b e ne cessary to bot h  nor malize GAG turnover an d act iv a te r e qu isite  osteog e ni c sig na li ngpa t hw ays i n e piphyse al cartila ge.  I n Aim 1 we w i ll  define te mpo ral and spat ial  relat io nsh i ps be twe en GA G accu m ulatio n and epi ph y seal c h ondrocy t e  d iffe rentiation potent i al at key stagesof bon ed is e a se
 effectively_treat bone_disease in MPS VII,_it will_be_necessary to_both_normalize GAG turnover_and activate requisite_osteogenic signaling pathways in_epiphyseal cartilage. In_Aim_1 we will define temporal and spatial relationships between GAG accumulation and epiphyseal chondrocyte_differentiation_potential at_key_stages_of bone disease