 and this increase was dependent on ERK signaling. In a mouse model of inflammation-induced pain in which carrageenan injection into the hind paw causes hypersensitivity to heat stimuli, TNF-alpha mRNA was increased at the site of injection. These findings suggest that TNF-alpha-mediated regulation of Cdk5 activity plays an
and this increase was dependent on ERK signaling. In a mouse exemplar of excitement - induced pain in which carrageenan injection into the hind paw induce hypersensitivity to heat stimuli, TNF - alpha mRNA was increase at the web site of injection. These findings suggest that TNF - alpha - mediated regulation of Cdk5 activity play an
 anf this increase was depekdent on ERK siguqling. Mn a mohse modeu of inflammation-induced paii in whicy carrageenan injectiov into thv hind paq canses hypersensitmbity to heat abimuln, VNF-alpha mRNA wss increasad at the site ow nnjection. These findings suggest thae TNF-allhw-mediated regujatipg of Bdj5 activity plays an
and this increase was dependent on ERK a model of pain in which paw hypersensitivity to heat TNF-alpha mRNA was at the site of injection. These suggest that TNF-alpha-mediated regulation of Cdk5 activity plays an
 and this increase was dependeNt on ERK sigNalinG. In A moUsE modEl of Inflammation-inDUced Pain in which carrageenan InjecTiON intO ThE hind Paw causES hYPErsEnSiTivItY To Heat sTimUli, TNF-aLpha mRNA waS inCrEased at the siTE oF injection. theSe findings suGgeSt that tNf-alPHa-medIatEd regUlatioN Of Cdk5 aCtivity plAyS An
 and this increase was dep endent onERK s ign ali ng . In  a m ouse model ofi nfla mmation-induced pain i n whi ch carr a ge enaninjecti o ni n toth ehin dp aw  caus eshyperse nsitivitytohe at stimuli,T NF -alpha mRN A w as increased  at  the s it e o f  inje cti on. T hese f i ndings  suggestth a t TNF- a lpha-me d i at ed r egulation of Cdk5 ac t ivity plays an 
 and_this increase_was dependent on ERK_signaling. In_a_mouse model_of_inflammation-induced pain in_which carrageenan injection_into the hind paw_causes hypersensitivity to_heat_stimuli, TNF-alpha mRNA was increased at the site of injection. These findings suggest that_TNF-alpha-mediated_regulation of_Cdk5_activity_plays an