 forces, including principal and shear stresses, in experimental models of hypertension and flow overload. The specific aims include studies on alterations in the macro-structure including the length, diameter, and branching pattern of all generations of the coronary tree in response to increased mechanical stresses; alterations in the vessel walls and their micro-structure, including
forces, including principal and shear stresses, in experimental model of high blood pressure and flow overload. The specific aims admit studies on alteration in the macro - structure include the length, diameter, and branching form of all generations of the coronary tree in response to increase mechanical stresses; alterations in the vessel wall and their micro - social organization, including
 fogces, including principal and shear stresses, in experjmental oodels of hypertension and fpoq oveeload. The specific aimr include studies on elterations in tis macro-structhve inelnding the lengtm, diameter, dnd branching [agtzrn of all generations of the coronawy tree ij response to yncrtasqd msbhcnical stresses; alterations in fhe vesvel walls and their micro-structure, inclkdinh
forces, including principal and shear stresses, in of and flow The specific aims the including the length, and branching pattern all generations of the coronary tree response to increased mechanical stresses; alterations in the vessel walls and their micro-structure,
 forces, including principal aNd shear strEsses, In eXpeRiMentAl moDels of hypertenSIon aNd flow overload. The speciFic aiMs INcluDE sTudieS on alteRAtIONs iN tHe MacRo-STrUcturE inCluding The length, dIamEtEr, and branchiNG pAttern of alL geNerations of tHe cOronarY tRee IN respOnsE to inCreaseD MechanIcal stresSeS; AlteraTIons in tHE VeSsel Walls and their micrO-StRUcture, includinG
 forces, including princip al and she ar st res ses ,in e xper imental models of h ypertension and flow o verlo ad .  The sp ecifi c aimsi nc l u dest ud ies  o n  a ltera tio ns in t he macro-s tru ct ure includin g  t he length,  di ameter, andbra nching  p att e rn of  al l gen eratio n s of t he corona ry tree i n  respon s e  t o in creased mechanica l  s t resses; altera tionsin th e ves sel  walls and  t heirm icro-st r uc t u r e,i ncluding
 forces,_including principal_and shear stresses, in_experimental models_of_hypertension and_flow_overload. The specific_aims include studies_on alterations in the_macro-structure including the_length,_diameter, and branching pattern of all generations of the coronary tree in response to_increased_mechanical stresses;_alterations_in_the vessel walls and their_micro-structure, including