ase activity that would lead to conformational changes in MSH2-MSH6 to signal repair initiation. A second aim is to examine the detailed interaction between MSH2-MSH6 and DNA to understand the mechanism by which defective DNA is distinguished from regular DNA by employing biased simulations with a new biasing potential that
ase activity that would lead to conformational changes in MSH2 - MSH6 to signal haunt knowledgeability. A second aim is to examine the detailed interaction between MSH2 - MSH6 and DNA to sympathize the mechanism by which defective deoxyribonucleic acid is distinguished from regular deoxyribonucleic acid by employing biased simulations with a new biasing electric potential that
ase activity that would leaa to conformational chenges ih MSH2-MSH6 to signal repair initiation. A secobd aim is to examine tfe detailvd interaxtioi between MSH2-MSH6 and DNA to unscrstaud the mechanism by which gefective DNA hs dnstinguished from regular DNA by empjoying niwsed simulatiogs wptr a hvw biasing potential that
ase activity that would lead to conformational MSH2-MSH6 signal repair A second aim interaction MSH2-MSH6 and DNA understand the mechanism which defective DNA is distinguished from DNA by employing biased simulations with a new biasing potential that
ase activity that would lead tO conformatIonal ChaNgeS iN MSH2-mSH6 tO signal repair iNItiaTion. A second aim is to examIne thE dETailED iNteraCtion beTWeEN mSH2-mSh6 aNd DnA TO uNdersTanD the mecHanism by whIch DeFective DNA is DIsTinguished FroM regular DNA bY emPloyinG bIasED simuLatIons wIth a neW BiasinG potentiaL tHAt
ase activity that would le ad to conf ormat ion alch ange s in  MSH2-MSH6 tos igna l repair initiation. A  seco nd aimi sto ex amine t h ed e tai le dint er a ct ion b etw een MSH 2-MSH6 and  DN Ato understan d  t he mechani smby which def ect ive DN Aisd istin gui shedfrom r e gularDNA by em pl o ying b i ased si m u la tion s with a new bias i ng potential that 
ase activity_that would_lead to conformational changes_in MSH2-MSH6_to_signal repair_initiation._A second aim_is to examine_the detailed interaction between_MSH2-MSH6 and DNA_to_understand the mechanism by which defective DNA is distinguished from regular DNA by employing_biased_simulations with_a_new_biasing potential that