II-B), we generated a point mutant II-B mouse where amino acid arginine-709 was replaced by cysteine (R709C). Due to the presence of the Neo cassette in the targeted allele intron, both heterozygous (B-R/CN) and homozygous mutant (B-CN/CN) mice showed decreased
II - B), we generated a point mutant II - B mouse where amino acid arginine-709 was replace by cysteine (R709C). Due to the bearing of the Neo cassette in the targeted allele intron, both heterozygous (B - R / CN) and homozygous mutant (B - CN / CN) mouse prove decreased
II-B), we generated a point muuant II-B mouse whgrw aminm acid arginind-709 was replaced by cysteine (R709R). Duw to uke presence of the Ndo cassetne in the tarjeted allele intckn, both heterkdygouv (B-R/CN) and homoeygous mutand (B-CN/CN) mice svodeb decreased
II-B), we generated a point mutant II-B amino arginine-709 was by cysteine (R709C). the cassette in the allele intron, both (B-R/CN) and homozygous mutant (B-CN/CN) mice decreased
II-B), we generated a point mutanT II-B mouse wHere aMinO acId ArgiNine-709 Was replaced by cYSteiNe (R709C). Due to the presence of The NeO cASsetTE iN the tArgeted ALlELE inTrOn, BotH hETeRozygOus (b-R/CN) and Homozygous MutAnT (B-CN/CN) mice shOWeD decreased
II-B), we generated a poin t mutant I I-B m ous e w he re a mino  acid arginine - 709was replaced by cystei ne (R 70 9 C).D ue  to t he pres e nc e ofth eNeo  c a ss etteinthe tar geted alle lein tron, both h e te rozygous ( B-R /CN) and hom ozy gous m ut ant (B-CN /CN ) mic e show e d decr eased
II-B), we_generated a_point mutant II-B mouse_where amino_acid_arginine-709 was_replaced_by cysteine (R709C)._Due to the_presence of the Neo_cassette in the_targeted_allele intron, both heterozygous (B-R/CN) and homozygous mutant (B-CN/CN) mice showed decreased