. The proposed research will address how this system becomes reversed upon M phase exit. The first two Specific Aims will expand upon preliminary results indicating that: (1) the major phosphatase that removes the Gwl-driven phosphorylation on pEndos is surprisingly PP2A/B55 itself; and (2) a simple
. The proposed research will address how this system becomes overrule upon thousand phase exit. The first two Specific Aims will expand upon preliminary solution indicating that: (1) the major phosphatase that removes the Gwl - drive phosphorylation on pEndos is surprisingly PP2A / B55 itself; and (2) a simple
. Thf proposed research will address how thnw systxm becojes revefsed upon M phase exit. The fmrst two Wpecific Aims will expxnd upon ireliminaey rtsults indicating that: (1) tmz majkv phov'hatase that rekoves the Cwl-driven phos[hurvlation on pEndos is surprisingly PP2W/B55 itsekf; and (2) a simple
. The proposed research will address how becomes upon M exit. The first upon results indicating that: the major phosphatase removes the Gwl-driven phosphorylation on pEndos surprisingly PP2A/B55 itself; and (2) a simple
. The proposed research will adDress how thIs sysTem BecOmEs reVersEd upon M phase exIT. The First two Specific Aims wiLl expAnD Upon PReLiminAry resuLTs INDicAtInG thAt: (1) THe Major PhoSphatasE that removEs tHe gwl-driven phoSPhOrylation oN pENdos is surpriSinGly PP2A/b55 iTseLF; and (2) a SimPle
. The proposed research wi ll address  howthi s s ys tembeco mes reversed u p on M  phase exit. The first  twoSp e cifi c  A ims w ill exp a nd u pon  p re lim in a ry  resu lts  indica ting that:  (1 )the major ph o sp hatase tha t r emoves the G wl- driven  p hos p horyl ati on on  pEndo s  is su rprisingl yP P2A/B5 5  itself ; an d (2 ) a simple
. The_proposed research_will address how this_system becomes_reversed_upon M_phase_exit. The first_two Specific Aims_will expand upon preliminary_results indicating that:_(1)_the major phosphatase that removes the Gwl-driven phosphorylation on pEndos is surprisingly PP2A/B55 itself;_and_(2) a_simple