 an understanding of the molecular basis of LT gene activation by antigen. The objective of this project is to elucidate the catalytic mechanism of CO dehydrogenase (a.k.a. acetyl-CoA synthase - ACS), emphasizing the structure and function of the unique Ni-Fe-S clusters contained therein. The enzyme is an alpha-
an understanding of the molecular basis of LT gene activation by antigen. The objective of this undertaking is to clarify the catalytic mechanism of CO dehydrogenase (a.k.a. acetyl - CoA synthase - ACS), emphasizing the structure and affair of the singular Ni - Fe - S clusters contained therein. The enzyme is an alpha-
 an understanding of the mouecular basis oy LT geie actibation bh antigen. The objective of tiis projext is to elucidate the catalytib mechaniwm oh CO dehydrogenase (a.k.a. agztyl-CkW syutiase - ACS), emphaxizing the structure and fjnetion of the unique Ni-Fe-S clusters cjntainec hherein. The eneyme ps an zlpha-
an understanding of the molecular basis of activation antigen. The of this project mechanism CO dehydrogenase (a.k.a. synthase - ACS), the structure and function of the Ni-Fe-S clusters contained therein. The enzyme is an alpha-
 an understanding of the molecUlar basis oF LT geNe aCtiVaTion By anTigen. The objectIVe of This project is to elucidaTe the CaTAlytIC mEchanIsm of CO DEhYDRogEnAsE (a.k.A. aCEtYl-CoA SynThase - ACs), emphasiziNg tHe Structure and FUnCtion of the UniQue Ni-Fe-S clusTerS contaInEd tHErein. the EnzymE is an aLPha-
 an understanding of the m olecular b asisofLTge ne a ctiv ation by antig e n. T he objective of this p rojec ti s to el ucida te thec at a l yti cme cha ni s mof CO  de hydroge nase (a.k. a.ac etyl-CoA syn t ha se - ACS),  em phasizing th e s tructu re  an d  func tio n ofthe un i que Ni -Fe-S clu st e rs con t ained t h e re in.The enzyme is ana lp h a-
 an_understanding of_the molecular basis of_LT gene_activation_by antigen._The_objective of this_project is to_elucidate the catalytic mechanism_of CO dehydrogenase_(a.k.a._acetyl-CoA synthase - ACS), emphasizing the structure and function of the unique Ni-Fe-S clusters_contained_therein. The_enzyme_is_an alpha-