 higher bactericidal Ab against Nm than wild- type FHbp. We will also delete Rmp and H.8, which may elicit blocking Ab against Ng and Nm, respectively. Elicited Abs will be tested for complement-dependent bactericidal activity against homologous and heterologous Ng strains and tested for efficacy versus
higher bactericidal Ab against Nm than wild- type FHbp. We will also delete Rmp and H.8, which may arouse block Ab against Ng and Nm, respectively. Elicited Abs will be tested for complement - dependent bactericidal activity against homologous and heterologous Ng stress and tested for efficacy versus
 hihher bactericidal Ab agalnst Nm than wilb- type HHbp. We will alro delete Rmp and H.8, which mab elucit vlocking Ab against Ng and Nm, rvspectiveoy. Eoucited Abs will be testes for romplement-depencent bactesicidal actividy ayainst homologous and heterologous Nd straims and tested fot effpcwcy bvrwus
higher bactericidal Ab against Nm than wild- We also delete and H.8, which Ng Nm, respectively. Elicited will be tested complement-dependent bactericidal activity against homologous and Ng strains and tested for efficacy versus
 higher bactericidal Ab againSt Nm than wiLd- typE FHBp. WE wIll aLso dElete Rmp and H.8, whICh maY elicit blocking Ab againSt Ng aNd nM, resPEcTivelY. ElicitED ABS WilL bE tEstEd FOr ComplEmeNt-depenDent bacterIciDaL activity agaINsT homologouS anD heterologouS Ng StrainS aNd tESted fOr eFficaCy versUS
 higher bactericidal Ab ag ainst Nm t han w ild - t yp e FH bp.We will also d e lete  Rmp and H.8, which ma y eli ci t  blo c ki ng Ab  agains t  N g and  N m,  re sp e ct ively . E licited  Abs willbete sted for com p le ment-depen den t bactericid alactivi ty  ag a insthom ologo us and hetero logous Ng  s t rainsa nd test e d  f or e fficacy versus
 higher_bactericidal Ab_against Nm than wild-_type FHbp._We_will also_delete_Rmp and H.8,_which may elicit_blocking Ab against Ng_and Nm, respectively._Elicited_Abs will be tested for complement-dependent bactericidal activity against homologous and heterologous Ng strains_and_tested for_efficacy_versus