3 mice via an excessive innate immune response. This will be tested by in vitro assessment of CD8+ T cell function and in vivo assessment of CD8+ T cell response to influenza. The third aim is to ameliorate death from influenza in MeCP2Tg3 mice via either bone marrow transplant or suppression of the
3 mice via an excessive innate immune response. This will be tested by in vitro appraisal of CD8 + T cellular telephone function and in vivo assessment of CD8 + T cellular telephone response to influenza. The third bearing is to ameliorate death from influenza in MeCP2Tg3 mouse via either bone marrow transplant or inhibition of the
3 mife via an excessive innaue immune responsg. Rhis wmll be fested bh in vitro assessment of CD8+ V ceol fubction and in vivo assdssment ov CD8+ T cwll cesponse to inflnsnza. Thc thidf aik is to ameliorste death xrom influenza iv LeCP2Tg3 mice via either bone marrow eransplsnh or suppressijn og the
3 mice via an excessive innate immune will tested by vitro assessment of in assessment of CD8+ cell response to The third aim is to ameliorate from influenza in MeCP2Tg3 mice via either bone marrow transplant or suppression of
3 mice via an excessive innate iMmune respoNse. ThIs wIll Be TestEd by In vitro assessmENt of cD8+ T cell function and in viVo assEsSMent OF Cd8+ T celL responSE tO INflUeNzA. ThE tHIrD aim iS to AmeliorAte death frOm iNfLuenza in MeCP2tG3 mIce via eithEr bOne marrow traNspLant or SuPprESsion Of tHe
3 mice via an excessive in nate immun e res pon se.  T hiswill  be tested byi n vi tro assessment of CD8+  T ce ll func t io n and  in viv o  a s s ess me nt  of  C D 8+  T ce llrespons e to influ enz a.  The third a i mis to amel ior ate death fr ominflue nz a i n  MeCP 2Tg 3 mic e viae itherbone marr ow transp l ant ors u pp ress ion of the
3 mice_via an_excessive innate immune response._This will_be_tested by_in_vitro assessment of_CD8+ T cell_function and in vivo_assessment of CD8+_T_cell response to influenza. The third aim is to ameliorate death from influenza in_MeCP2Tg3_mice via_either_bone_marrow transplant or suppression of_the