 in pulmonary fibrosis and emphysema, both of which are of extensive clinical significance. Recent reports of the effects of ECM on cellular proliferation and differentiation make it clear that ECM constituents cannot be regarded as an inert scaffold, but that they exert significant effects at the metabolic level. The overall goal of the proposed research is thus
in pulmonary fibrosis and emphysema, both of which are of extensive clinical significance. Recent report of the effect of ECM on cellular proliferation and differentiation make it clear that ECM constituent cannot be regarded as an inert scaffold, but that they exert meaning effects at the metabolic level. The overall goal of the propose research is thus
 in pulmonary fibrosis and tmphysema, both of which ere of sxtensivd clinical significance. Receit rwportw of the effects of ECO on cellllar proluferetion and differxhtiatiok maks it elxar that ECM cokstituents wannot be regasddd as an inert scaffold, but that they exert xihnificant effests se ths metabolic level. The overall goal of the proposed resrarch is thus
in pulmonary fibrosis and emphysema, both of of clinical significance. reports of the proliferation differentiation make it that ECM constituents be regarded as an inert scaffold, that they exert significant effects at the metabolic level. The overall goal of proposed research is thus
 in pulmonary fibrosis and empHysema, both Of whiCh aRe oF eXtenSive Clinical signifICancE. Recent reports of the effEcts oF Ecm on cELlUlar pRoliferATiON And DiFfEreNtIAtIon maKe iT clear tHat ECM consTitUeNts cannot be rEGaRded as an inErt Scaffold, but tHat They exErT siGNificAnt EffecTs at thE MetaboLic level. THe OVerall GOal of thE PRoPoseD research is thus
 in pulmonary fibrosis and  emphysema , bot h o f w hi ch a re o f extensive cl i nica l significance. Recent  repo rt s  oft he  effe cts ofE CM o n c el lu lar  p r ol ifera tio n and d ifferentia tio nmake it clea r  t hat ECM co nst ituents cann otbe reg ar ded as an  in ert s caffol d , butthat they  e x ert si g nifican t ef fect s at the metaboli c  l e vel. The overa ll goa lo ft h e p rop osed resea rc h ist hus
 in_pulmonary fibrosis_and emphysema, both of_which are_of_extensive clinical_significance._Recent reports of_the effects of_ECM on cellular proliferation_and differentiation make_it_clear that ECM constituents cannot be regarded as an inert scaffold, but that they_exert_significant effects_at_the_metabolic level. The overall goal_of the proposed research is_thus