 of self-antigens. In this new R01 proposal, we propose to generate transgenic mice carrying genes encoding two of the broadly neutralizing HIV antibodies 4E10 and b12 to investigate these hypotheses and to provide tools to study and rank potential HIV vaccine candidates. In the first instance, we propose to use mice carrying HIV
of self - antigens. In this new R01 proposal, we propose to render transgenic mouse carrying genes encoding two of the broadly neutralize HIV antibodies 4E10 and b12 to investigate these hypotheses and to provide cock to learn and rank likely HIV vaccine campaigner. In the first example, we propose to use shiner impart HIV
 of self-antigens. In this ned R01 proposal, we proposx to geherate tfansgenic mice carrying gened wncodung two of the broadly neutraliding HIV qntiuodies 4E10 and b12 to investlyate fmese ky'otheses and to provide tmols to study dna xank potential HIV vaccine candidatef. In thr virst instance, we kro[ose no use mice carrying HIV
of self-antigens. In this new R01 proposal, to transgenic mice genes encoding two antibodies and b12 to these hypotheses and provide tools to study and rank HIV vaccine candidates. In the first instance, we propose to use mice carrying
 of self-antigens. In this new R01 pRoposal, we pRoposE to GenErAte tRansGenic mice carryINg geNes encoding two of the broAdly nEuTRaliZInG HIV aNtibodiES 4E10 AND b12 tO iNvEstIgATe These HypOtheses And to proviDe tOoLs to study and RAnK potential hIV Vaccine candiDatEs. In thE fIrsT InstaNce, We proPose to USe mice Carrying HiV
 of self-antigens. In this  new R01 p ropos al,  we  p ropo se t o generate tra n sgen ic mice carrying genes  enco di n g tw o  o f the  broadl y  n e u tra li zi ngHI V  a ntibo die s 4E10and b12 to  in ve stigate thes e  h ypothesesand  to providetoo ls tost udy and r ank  pote ntialH IV vac cine cand id a tes. I n  the fi r s tinst ance, we proposet ou se mice carryi ng HIV 
 of_self-antigens. In_this new R01 proposal,_we propose_to_generate transgenic_mice_carrying genes encoding_two of the_broadly neutralizing HIV antibodies_4E10 and b12_to_investigate these hypotheses and to provide tools to study and rank potential HIV vaccine_candidates._In the_first_instance,_we propose to use mice_carrying HIV