 aggregation follows a seeding-nucleation mechanism and involves several intermediates, including soluble oligomers and protofibrils. Recent evidence has shown that tau oligomers are circulating in biological fluids and these structures appear to be key for inducing brain degeneration in AD. Our working hypothesis is that detection of misfolded tau oligomers circulating
aggregation follows a seeding - nucleation mechanism and involves several intermediate, include soluble oligomers and protofibrils. Recent evidence has shown that tau oligomers are circulate in biological fluid and these structures appear to be cardinal for inducing brain degeneration in AD. Our ferment hypothesis is that detection of misfolded tau oligomers circulate
 aghregation follows a seedlng-nucleation meeyanism and ihvolves reveral intermediates, includmng woluboe oligomers and protowibrils. Rvcent evieenct has shown that vzu oligomers zve cixcnlating in biolpgical fluhds and these vtfuetures appear to be key for inducing brain ceheneration in WD. Olr woripnn hypothesis is that detection or misfonded tau oligpmers circulating
aggregation follows a seeding-nucleation mechanism and involves including oligomers and Recent evidence has circulating biological fluids and structures appear to key for inducing brain degeneration in Our working hypothesis is that detection of misfolded tau oligomers circulating
 aggregation follows a seedinG-nucleatioN mechAniSm aNd InvoLves Several intermeDIateS, including soluble oligoMers aNd PRotoFIbRils. REcent evIDeNCE haS sHoWn tHaT TaU oligOmeRs are ciRculating iN biOlOgical fluids ANd These strucTurEs appear to be Key For indUcIng BRain dEgeNeratIon in Ad. our worKing hypotHeSIs is thAT detectION oF misFolded tau oligomerS CiRCulating
 aggregation follows a see ding-nucle ation  me cha ni sm a nd i nvolves severa l  int ermediates, includingsolub le olig o me rs an d proto f ib r i ls.  R ec ent  e v id encehas  shownthat tau o lig om ers are circ u la ting in bi olo gical fluids  an d thes estr u cture s a ppear  to be key fo r inducin gb rain d e generat i o nin A D. Our working hy p ot h esis is that d etecti on of m isf old ed tau oli go mersc irculat i ng 
 aggregation_follows a_seeding-nucleation mechanism and involves_several intermediates,_including_soluble oligomers_and_protofibrils. Recent evidence_has shown that_tau oligomers are circulating_in biological fluids_and_these structures appear to be key for inducing brain degeneration in AD. Our working_hypothesis_is that_detection_of_misfolded tau oligomers circulating