, the KSPXK peptide showed a mainly extended conformation with beta-turns. These differences revealed a structural specificity for the substrate of this kinase. using two dimensional NMR methods and molecular modeling. We are also studying the mechanism of cdk5 activation. Though, cdk5 is similar to other cdc2
, the KSPXK peptide showed a mainly extended conformation with beta - turn. These dispute revealed a structural specificity for the substrate of this kinase. using two dimensional NMR method acting and molecular modeling. We are also learn the mechanism of cdk5 energizing. Though, cdk5 is similar to other cdc2
, thf KSPXK peptide showed a mainly extendeb confocmation with bega-turns. These differences retealwd a wtructural specificity for the dubstratw of rhis kinasx. using bco dijcnsiouao NMR methods snd molecunar modeling. Wa xrz also studying the mechanism of cdk5 activayiln. Though, cdk5 ys spmylar no other cdc2
, the KSPXK peptide showed a mainly with These differences a structural specificity kinase. two dimensional NMR and molecular modeling. are also studying the mechanism of activation. Though, cdk5 is similar to other cdc2
, the KSPXK peptide showed a maiNly extendeD confOrmAtiOn With Beta-Turns. These diffERencEs revealed a structural sPecifIcITy foR ThE subsTrate of THiS KInaSe. UsIng TwO DiMensiOnaL NMR metHods and molEcuLaR modeling. We aRE aLso studyinG thE mechanism of Cdk5 ActivaTiOn. THOugh, cDk5 iS simiLar to oTHer cdc2
, the KSPXK peptide showed  a mainlyexten ded  co nf orma tion  with beta-tur n s. T hese differences revea led a  s t ruct u ra l spe cificit y  f o r  th esu bst ra t eof th iskinase.  using two  di me nsional NMRm et hods and m ole cular modeli ng.  We ar eals o  stud yin g the  mecha n ism of  cdk5 act iv a tion.T hough,c d k5  issimilar to otherc dc 2 
, the_KSPXK peptide_showed a mainly extended_conformation with_beta-turns._These differences_revealed_a structural specificity_for the substrate_of this kinase. using_two dimensional NMR_methods_and molecular modeling. We are also studying the mechanism of cdk5 activation. Though, cdk5_is_similar to_other_cdc2