 critical cellular processes. Notably, abnormal lysine acetylation is observed in multiple human disorders, including cancer; thus HDACs are a validated drug target. Despite their critical biological functions and clinical roles as drug targets, little is known about the molecular basis for HDAC substrate specificity and inhibition. This is particularly the case for HDACs 10
critical cellular processes. Notably, abnormal lysine acetylation is observed in multiple human disorders, including cancer; therefore HDACs are a validated drug prey. Despite their critical biological functions and clinical roles as drug target, fiddling is known about the molecular basis for HDAC substrate specificity and prohibition. This is particularly the case for HDACs 10
 crltical cellular processer. Notably, abnormal lysmne acefylation is observed in multiple humen dusordtgs, including cancer; tfus HDACs are a vqlideted drug target. Despite their gritieao biological fonctions and clinical rolev xs drug targets, little is known about the mokefular basis fot HDAB fubsfgaue specificity and inhibition. Thia is pagticularly the caxe for HDACs 10
critical cellular processes. Notably, abnormal lysine acetylation in human disorders, cancer; thus HDACs Despite critical biological functions clinical roles as targets, little is known about the basis for HDAC substrate specificity and inhibition. This is particularly the case for 10
 critical cellular processes. notably, abnOrmal LysIne AcEtylAtioN is observed in mULtipLe human disorders, includIng caNcER; thuS hDaCs arE a validATeD DRug TaRgEt. DEsPItE theiR crItical bIological fUncTiOns and clinicAL rOles as drug TarGets, little is KnoWn abouT tHe mOLeculAr bAsis fOr HDAC SUbstraTe specifiCiTY and inHIbition. tHIs Is paRticularly the case FOr hdACs 10
 critical cellular process es. Notabl y, ab nor mal  l ysin e ac etylation is o b serv ed in multiple human d isord er s , in c lu dingcancer; th u s  HD AC sare  a va lidat eddrug ta rget. Desp ite  t heir critica l  b iologicalfun ctions and c lin ical r ol esa s dru g t arget s, lit t le isknown abo ut the mo l ecularb a si s fo r HDAC substrates pe c ificity and in hibiti on .  T h i s i s p articularl ythe c a se forH DA C s 10
 critical_cellular processes._Notably, abnormal lysine acetylation_is observed_in_multiple human_disorders,_including cancer; thus_HDACs are a_validated drug target. Despite_their critical biological_functions_and clinical roles as drug targets, little is known about the molecular basis for_HDAC_substrate specificity_and_inhibition._This is particularly the case_for HDACs 10