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) determining if the drug-induced changes in to lactate conversion parallel target inhibition also so in xenografts vivo, and 4) if treatment-induced alterations in pyruvate metabolism by hyperpolarized 130 MRSI can be used alone, or in combination with
) determining if the drug-inducEd changes iN 13C pyrUvaTe tO 130 lActaTe coNversion that paRAlleL target inhibition and drUg senSiTIvitY In Vitro Also do sO In XENogRaFtS in ViVO, aNd 4) detErmIning if Treatment-iNduCeD alterations IN pYruvate metAboLism detected By hYperpoLaRizED 130 MRSI Can Be useD alone, OR in comBination wItH
) determining if the drug- induced ch anges  in  13 Cpyru vate  to 130 lactat e  con version that paralleltarge ti nhib i ti on an d drugs en s i tiv it yinvi t ro  also  do  so inxenografts  in  v ivo, and 4)d et ermining i f t reatment-ind uce d alte ra tio n s inpyr uvate  metab o lism d etected b yh yperpo l arized1 3 0MRSI  can be used alon e ,o r in combinati on wit h
) determining_if the_drug-induced changes in 13C_pyruvate to_130_lactate conversion_that_parallel target inhibition_and drug sensitivity_in vitro also do_so in xenografts_in_vivo, and 4) determining if treatment-induced alterations in pyruvate metabolism detected by hyperpolarized 130_MRSI_can be_used_alone,_or in combination with