 test the hyposthesis that patients with chronic fatigue syndrome manifest a characteristic neuroendocrine defect, namely, a reduction in adrenal glucocorticoid secretion mediated by a failure in the central release of corticotropin-releasing hormone (CRH). Specifically, we will confirm and extend our preliminary findings of impaired activation of the H
test the hyposthesis that patients with chronic fatigue syndrome manifest a characteristic neuroendocrine blemish, namely, a decrease in adrenal glucocorticoid secretion mediate by a failure in the cardinal release of adrenocorticotropic hormone - releasing hormone (CRH). Specifically, we will confirm and extend our preliminary determination of impaired activation of the hydrogen
 tedt the hyposthesis that katients with chronic favigue sgndrome oanifest a characteristic nenroebdocrune defect, namely, a reauction ij adrenao glncocorticoid seccstion mcbiates by c hailure in the gentral relaase of corticmtfo'in-releasing hormone (CRH). Specificallr, we wikl confirm and evtenc our irtliminary findings of impaired acfivatioi of the H
test the hyposthesis that patients with chronic manifest characteristic neuroendocrine namely, a reduction by failure in the release of corticotropin-releasing (CRH). Specifically, we will confirm and our preliminary findings of impaired activation of the H
 test the hyposthesis that patIents with cHroniC faTigUe SyndRome Manifest a charaCTeriStic neuroendocrine defeCt, namElY, A redUCtIon in Adrenal GLuCOCorTiCoId sEcREtIon meDiaTed by a fAilure in thE ceNtRal release of COrTicotropin-RelEasing hormonE (CRh). SpeciFiCalLY, we wiLl cOnfirM and exTEnd our PreliminaRy FIndingS Of impaiRED aCtivAtion of the H
 test the hyposthesis that  patientswithchr oni cfati guesyndrome manif e st a  characteristic neuroe ndocr in e  def e ct , nam ely, ar ed u c tio nin  ad re n al  gluc oco rticoid  secretion  me di ated by a fa i lu re in thecen tral release  of  corti co tro p in-re lea singhormon e  (CRH) . Specifi ca l ly, we will co n f ir m an d extend our prel i mi n ary findings o f impa ir e da c tiv ati on of theH
 test_the hyposthesis_that patients with chronic_fatigue syndrome_manifest_a characteristic_neuroendocrine_defect, namely, a_reduction in adrenal_glucocorticoid secretion mediated by_a failure in_the_central release of corticotropin-releasing hormone (CRH). Specifically, we will confirm and extend our preliminary_findings_of impaired_activation_of_the H