. While not within the scope of the present proposal, we anticipate that therapeutic interventions that abrogate hypoxia-induced blood flow decreases and changes in markers of vascular damage detected in these human models will decrease frequency of crisis and lessen the degree of end-organ damage if tested in larger clinical trials. In this project, mechanisms
. While not within the scope of the present proposal, we anticipate that therapeutic interposition that abrogate hypoxia - induce blood flow decreases and change in markers of vascular damage detect in these human models will decrease frequency of crisis and lessen the degree of goal - organ damage if test in larger clinical trials. In this undertaking, mechanisms
. Whlle not within the scope of the present proposel, we ahticipatd that therapeutic interventmons that abrogate hypoxia-inducdd blood vlow deceeasts and changes in markers of vaagular vamage detected in these vuman models whlu becrease frequency of crisis and lesfen the dfgree of end-ordan cwmags if tested in larger clinical trizls. In uhis project, mechamisms
. While not within the scope of proposal, anticipate that interventions that abrogate changes markers of vascular detected in these models will decrease frequency of crisis lessen the degree of end-organ damage if tested in larger clinical trials. In project, mechanisms
. While not within the scope of tHe present pRoposAl, wE anTiCipaTe thAt therapeutic iNTervEntions that abrogate hypOxia-iNdUCed bLOoD flow DecreasES aND ChaNgEs In mArKErS of vaScuLar damaGe detected In tHeSe human modelS WiLl decrease FreQuency of crisIs aNd lessEn The DEgree Of eNd-orgAn damaGE if tesTed in largEr CLinicaL Trials. IN THiS proJect, mechanisms
. While not within the sco pe of theprese ntpro po sal,  weanticipate tha t  the rapeutic interventions  that  a b roga t ehypox ia-indu c ed b loo dfl owde c re asesand  change s in marke rsof  vascular da m ag e detected  in  these human  mo dels w il l d e creas e f reque ncy of crisis  and less en the de g ree ofe n d- orga n damage if teste d  i n  larger clinic al tri al s .I n  th isproject, m ec hanis m s
. While_not within_the scope of the_present proposal,_we_anticipate that_therapeutic_interventions that abrogate_hypoxia-induced blood flow_decreases and changes in_markers of vascular_damage_detected in these human models will decrease frequency of crisis and lessen the degree_of_end-organ damage_if_tested_in larger clinical trials. In_this project, mechanisms