 antigens on MHC class II in dendritic cells upon HSV-1 infection. Building on these preliminary studies, we propose to examine the importance of autophagy in both innate and adaptive immune responses using a variety of molecular and cell biological techniques and using established mouse models of virus infection. In the first Aim, we will determine the mechanism by
antigens on MHC class II in dendritic cells upon HSV-1 infection. Building on these preliminary report, we nominate to examine the importance of autophagy in both innate and adaptive immune responses use a variety of molecular and cell biological proficiency and use established shiner model of virus infection. In the first Aim, we will determine the mechanism by
 anhigens on MHC class II ik dendritic cells upon ISV-1 infsction. Bjilding on these preliminary srudiew, we propose to examind the implrtance if antophagy in both innate and adzitive mmmune responsex using a eariety of molacjlcr and cell biological techniques anq using edtablished moufe mpqels of virus infection. In the first Ajm, we wpll determine the mechanism by
antigens on MHC class II in dendritic HSV-1 Building on preliminary studies, we of in both innate adaptive immune responses a variety of molecular and cell techniques and using established mouse models of virus infection. In the first Aim, will determine the mechanism by
 antigens on MHC class II in denDritic cellS upon hSV-1 InfEcTion. builDing on these preLIminAry studies, we propose to eXaminE tHE impORtAnce oF autophAGy IN BotH iNnAte AnD AdAptivE imMune resPonses usinG a vArIety of molecuLAr And cell bioLogIcal techniquEs aNd usinG eStaBLisheD moUse moDels of VIrus inFection. In ThE First AIM, we will DETeRminE the mechanism by
 antigens on MHC class IIin dendrit ic ce lls  up on  HSV -1 i nfection. Buil d ingon these preliminary s tudie s, we p r op ose t o exami n et h e i mp or tan ce of  auto pha gy in b oth innate  an dadaptive imm u ne  responses  us ing a variet y o f mole cu lar and c ell  biol ogical techni ques andus i ng est a blished m ou se m odels of virus in f ec t ion. In the fi rst Ai m, we w ill  de termine th emecha n ism by
 antigens_on MHC_class II in dendritic_cells upon_HSV-1_infection. Building_on_these preliminary studies,_we propose to_examine the importance of_autophagy in both_innate_and adaptive immune responses using a variety of molecular and cell biological techniques and_using_established mouse_models_of_virus infection. In the first_Aim, we will determine the_mechanism by