 that the v-sis oncogene encodes a PDGF-related product whose transforming activity requires functional interaction with the PDGF receptor has suggested the importance of identifying the active site of the v-sis translational product. Site-directed mutagenesis of v-sis has localized an 89 codon stretch as its minimum transforming region and has shown
that the v - sis oncogene encodes a PDGF - related product whose transforming natural process command functional interaction with the PDGF receptor has suggested the importance of name the active site of the v - sis translational intersection. web site - directed mutagenesis of v - sis has localized an 89 codon stretch as its minimum transforming area and has shown
 thwt the v-sis oncogene encudes a PDGF-relajee prodnct whoae transworming activity requires fuictiinal unteraction with the PAGF recepnor has syggewred the im'krtance of idsktifynnj the active sije of the v-shs translationdl pxoduct. Site-directed mutagenesis of v-fis has llcalized an 89 cjdon ftrefbh as its minimum transforming degion end has shown
that the v-sis oncogene encodes a PDGF-related transforming requires functional with the PDGF of the active site the v-sis translational Site-directed mutagenesis of v-sis has localized 89 codon stretch as its minimum transforming region and has shown
 that the v-sis oncogene encodeS a PDGF-relaTed prOduCt wHoSe trAnsfOrming activity REquiRes functional interactiOn witH tHE PDGf ReCeptoR has sugGEsTED thE iMpOrtAnCE oF idenTifYing the Active site Of tHe V-sis translatIOnAl product. SIte-Directed mutaGenEsis of V-sIs hAS locaLizEd an 89 cOdon stREtch as Its minimuM tRAnsforMIng regiON AnD has Shown
 that the v-sis oncogene e ncodes a P DGF-r ela ted  p rodu ct w hose transform i ng a ctivity requires funct ional  i n tera c ti on wi th theP DG F rec ep to r h as su ggest edthe imp ortance of  id en tifying thea ct ive site o f t he v-sis tra nsl ationa lpro d uct.Sit e-dir ectedm utagen esis of v -s i s hasl ocalize d an  89codon stretch asi ts minimum transf orming  r e gi o n  an d h as shown
 that_the v-sis_oncogene encodes a PDGF-related_product whose_transforming_activity requires_functional_interaction with the_PDGF receptor has_suggested the importance of_identifying the active_site_of the v-sis translational product. Site-directed mutagenesis of v-sis has localized an 89 codon_stretch_as its_minimum_transforming_region and has shown