 unaffected. During virus replication, naturally occurring segments with sequence rearrangement are preferentially packaged over wild-type segments. The mechanism for the improved-replication phenotype is unclear, but may be connected to duplication of RNA sequences involved in packaging of the RV genome. As an extension of these observations, we used reverse genetics to engineer duplic
unaffected. During virus replication, naturally occurring segments with succession rearrangement are preferentially box over barbarian - type section. The mechanism for the better - replication phenotype is unclear, but may be connect to duplication of RNA sequences involve in packaging of the RV genome. As an extension of these observation, we used reverse genetics to mastermind duplic
 unwffected. During virus reklication, naturally occucring ssgments dith sequence rearrangement ere prefeeentially packaged ovef wild-typv segmentw. Tht mechanism for tis improyzd-repmlcatimi phenotype is onclear, but kay be connectad tl duplication of RNA sequences invojved in pwckaging of thg RV bqnoms. As an extension of these observafions, wt used reverse genrtics to engineer duplic
unaffected. During virus replication, naturally occurring segments rearrangement preferentially packaged wild-type segments. The is but may be to duplication of sequences involved in packaging of the genome. As an extension of these observations, we used reverse genetics to engineer
 unaffected. During virus replIcation, natUrallY ocCurRiNg seGmenTs with sequence REarrAngement are preferentiaLly paCkAGed oVEr Wild-tYpe segmENtS. tHe mEcHaNisM fOR tHe impRovEd-repliCation phenOtyPe Is unclear, but MAy Be connecteD to Duplication oF RNa sequeNcEs iNVolveD in PackaGing of THe RV geNome. As an eXtENsion oF These obSERvAtioNs, we used reverse geNEtICs to engineer duPlic
 unaffected. During virusreplicatio n, na tur all yoccu rrin g segments wit h  seq uence rearrangement ar e pre fe r enti a ll y pac kaged o v er w ild -t yp e s eg m en ts. T hemechani sm for the  im pr oved-replica t io n phenotyp e i s unclear, b utmay be  c onn e ctedtodupli cation of RNA  sequence si nvolve d  in pac k a gi ng o f the RV genome.A sa n extension of  these  o b se r v ati ons , we usedre verse genetic s  t o e ngi n eer duplic
 unaffected._During virus_replication, naturally occurring segments_with sequence_rearrangement_are preferentially_packaged_over wild-type segments._The mechanism for_the improved-replication phenotype is_unclear, but may_be_connected to duplication of RNA sequences involved in packaging of the RV genome. As_an_extension of_these_observations,_we used reverse genetics to_engineer duplic