polarized lactate to pyruvate (Lac/Pyr). We therefore hypothesize that measurement of Lac/Pyr could serve as an early indicator of drug action in patients following treatment with TMZ, PI3K inhibitors, and potentially a range of other agents. This hypothesis will be tested by 1) defining in vitro sensitivity
polarized lactate to pyruvate (Lac / Pyr). We therefore hypothesize that measurement of Lac / Pyr could serve as an early index of drug legal action in patients following discussion with TMZ, PI3 K inhibitors, and potentially a stove of other agents. This guess will be test by 1) defining in vitro sensitivity
polwrized lactate to pyruvaue (Lac/Pyr). We thergfire hy'othesiae that oeasurement of Lac/Pyr could deeve aw an early indicator ow drug acnion in pqtieits following trxztment with TJD, PI3K mnhibitors, and kotentially d range of othar ayents. This hypothesis will be tested by 1) degijing in vitro fensptyvitg
polarized lactate to pyruvate (Lac/Pyr). We therefore measurement Lac/Pyr could as an early patients treatment with TMZ, inhibitors, and potentially range of other agents. This hypothesis be tested by 1) defining in vitro sensitivity
polarized lactate to pyruvatE (Lac/Pyr). We tHerefOre HypOtHesiZe thAt measurement oF lac/PYr could serve as an early iNdicaToR Of drUG aCtion In patieNTs FOLloWiNg TreAtMEnT with tMZ, pI3K inhiBitors, and pOteNtIally a range oF OtHer agents. THis Hypothesis wiLl bE testeD bY 1) deFIning In vItro sEnsitiVIty
polarized lactate to pyruv ate (Lac/P yr).Wethe re fore  hyp othesize thatm easu rement of Lac/Pyr coul d ser ve as a n  e arlyindicat o ro f  dr ug  a cti on in  pati ent s follo wing treat men twith TMZ, PI 3 Kinhibitors , a nd potential lya rang eofo therage nts.This h y pothes is will b et estedb y 1) de f i ni ng i n vitro sensitivi t y
polarized lactate_to pyruvate_(Lac/Pyr). We therefore hypothesize_that measurement_of_Lac/Pyr could_serve_as an early_indicator of drug_action in patients following_treatment with TMZ,_PI3K_inhibitors, and potentially a range of other agents. This hypothesis will be tested by_1)_defining in_vitro_sensitivity