 signaling and to a lesser extent, that of AP-1. A systematic examination of the known steps in the NF-kappaB signaling pathway revealed that pateamine A does not affect early signaling steps up to the DNA binding by NF-kappaB. Instead, pateamine A was found to block the transactivation
signaling and to a lesser extent, that of AP-1. A systematic examination of the know step in the NF - kappaB signaling pathway revealed that pateamine vitamin a does not affect early bespeak dance step up to the DNA bind by NF - kappaB. Instead, pateamine A was found to stop the transactivation
 sihnaling and to a lesser txtent, that of AP-1. A systxmatic sxaminatkon of the known steps in thx NF-jappaV signaling pathway rexealed thwt pateanine Q does not affect ccrly algnalnnj steps up to tme DNA bindhng by NF-kappaT. Kndtead, pateamine A was found to bloch the ttajsactivation
signaling and to a lesser extent, that A examination of known steps in that A does not early signaling steps to the DNA binding by NF-kappaB. pateamine A was found to block the transactivation
 signaling and to a lesser exteNt, that of AP-1. a systEmaTic ExAminAtioN of the known stePS in tHe NF-kappaB signaling patHway rEvEAled THaT pateAmine A dOEs NOT afFeCt EarLy SIgNalinG stEps up to The DNA bindIng By nF-kappaB. InstEAd, Pateamine A Was Found to block The TransaCtIvaTIon
 signaling and to a lesser  extent, t hat o f A P-1 .A sy stem atic examinati o n of  the known steps in th e NF- ka p paBs ig nalin g pathw a yr e vea le dtha tp at eamin e A  does n ot affectear ly  signaling s t ep s up to th e D NA binding b y N F-kapp aB . I n stead , p ateam ine Aw as fou nd to blo ck the tr a nsactiv a t io n
 signaling_and to_a lesser extent, that_of AP-1._A_systematic examination_of_the known steps_in the NF-kappaB_signaling pathway revealed that_pateamine A does_not_affect early signaling steps up to the DNA binding by NF-kappaB. Instead, pateamine A_was_found to_block_the_transactivation