 of diabetic cardiovascular disease: We propose to create two new genetically altered mice. Aim 1a is to use the tet on system to allow expression of hAR in a time dependent manner. This system will allow us to test whether hAR expression in established lesions alters plaque morphology. These animals can also be used to produce tissue
of diabetic cardiovascular disease: We propose to create two new genetically altered mouse. Aim 1a is to practice the tet on system to allow formula of hAR in a fourth dimension dependent manner. This system will admit us to quiz whether hAR expression in establish lesions alters plaque morphology. These animal can also be used to produce tissue
 of diabetic cardiovascular disease: We prokowe to rreate fwo new eenetically altered mice. Aim 1a is ti use the tet on systeo to alloa expreswion if hAR in e time dc'endehb manuec. This system wlll allow uv to test whetvef kAR expression in established lesionf alterx olaque morpholjgy. Uhefe ahpmcls can also be used to produce tissue
of diabetic cardiovascular disease: We propose to new altered mice. 1a is to to expression of hAR a time dependent This system will allow us to whether hAR expression in established lesions alters plaque morphology. These animals can also used to produce tissue
 of diabetic cardiovascular dIsease: We prOpose To cReaTe Two nEw geNetically alterED micE. Aim 1a is to use the tet on syStem tO aLLow eXPrEssioN of hAR iN A tIME dePeNdEnt MaNNeR. This SysTem will Allow us to tEst WhEther hAR exprESsIon in estabLisHed lesions alTerS plaquE mOrpHOlogy. theSe aniMals caN Also be Used to proDuCE tissuE
 of diabetic cardiovascula r disease:  We p rop ose  t o cr eate  two new genet i call y altered mice. Aim 1a  is t ou se t h etet o n syste m  t o all ow  e xpr es s io n ofhAR  in a t ime depend ent  m anner. Thiss ys tem will a llo w us to test  wh etherhA R e x press ion  in e stabli s hed le sions alt er s  plaqu e  morpho l o gy . Th ese animals can a l so be used to pro duce t is s ue 
 of_diabetic cardiovascular_disease: We propose to_create two_new_genetically altered_mice._Aim 1a is_to use the_tet on system to_allow expression of_hAR_in a time dependent manner. This system will allow us to test whether hAR_expression_in established_lesions_alters_plaque morphology. These animals can_also be used to produce_tissue