 electron microscopic observations of these tissues. The mechanism of cell stacking and its maintenance will be investigated in embryonic skin and during the development and remission of essential fatty acid deficiency. Studies will be made of the permeability of normal and essential fatty acid deficient mouse skin to ultrastructural tracer molecules. We have shown that targeted therapy to
electron microscopic observations of these tissues. The mechanism of cell stacking and its maintenance will be investigate in embryonic hide and during the development and remission of essential fatty acid insufficiency. Studies will be made of the permeability of normal and substantive fatty acid insufficient mouse skin to ultrastructural tracer molecules. We have shown that targeted therapy to
 elfctron microscopic obseryations of these tissuev. The jechaniso of cell stacking and its meintwnanct will be investigaged in emhryonic wkin qnd during the devcjopmskt anb cemission of esxential fadty acid defichevcv. Studies will be made of the permeafility pf normal and esfentpaj fafny acid deficient mouse skin to ultrasuructural tracer mplecules. We have shown thah taggeted therapy to
electron microscopic observations of these tissues. The cell and its will be investigated the and remission of fatty acid deficiency. will be made of the permeability normal and essential fatty acid deficient mouse skin to ultrastructural tracer molecules. We shown that targeted therapy to
 electron microscopic observAtions of thEse tiSsuEs. THe MechAnisM of cell stackinG And iTs maintenance will be invEstigAtED in eMBrYonic Skin and DUrING thE dEvEloPmENt And reMisSion of eSsential faTty AcId deficiency. sTuDies will be MadE of the permeaBilIty of nOrMal ANd essEntIal faTty aciD DeficiEnt mouse sKiN To ultrAStructuRAL tRaceR molecules. We have sHOwN That targeted thErapy tO
 electron microscopic obse rvations o f the setis su es.Themechanism of c e ll s tacking and its mainte nance  w i ll b e  i nvest igatedi ne m bry on ic  sk in an d dur ing  the de velopmentand  r emission ofe ss ential fat tyacid deficie ncy . Stud ie s w i ll be  ma de of  the p e rmeabi lity of n or m al and essenti a l  f atty  acid deficient m o us e  skin to ultra struct ur a lt r ace r m olecules.We  have shown t h at t a rge t ed therapy to 
 electron_microscopic observations_of these tissues. The_mechanism of_cell_stacking and_its_maintenance will be_investigated in embryonic_skin and during the_development and remission_of_essential fatty acid deficiency. Studies will be made of the permeability of normal and_essential_fatty acid_deficient_mouse_skin to ultrastructural tracer molecules._We have shown that targeted_therapy to