 an energy deficit and impaired vesicular transport. We have shown that treatment of either TGF-beta1 (-/-) and TGF-beta1 (+/+) cells with TGF-beta in vitro results in rapid upregulation of expression of mitochondrial genes. Present investigations are aimed at determining the mechanism whereby TGF-beta1 regulates expression of
an energy deficit and impaired vesicular transport. We have shown that discussion of either TGF - beta1 (-/-) and TGF - beta1 (+ /+) cell with TGF - beta in vitro results in rapid upregulation of expression of mitochondrial gene. Present investigations are calculate at determining the mechanism whereby TGF - beta1 baffle construction of
 an energy deficit and impalred vesicular ttabsport. We habe shown that treatment of either TGH-betq1 (-/-) ane TGF-beta1 (+/+) cells with GGF-beta ij vitro eesuors in rapiv upregulation lf erpcession of mitoghondrial ganes. Present itvdscigations are aimed at determining tre mechsnlsm whereby TGS-bets1 reghlates expression of
an energy deficit and impaired vesicular transport. shown treatment of TGF-beta1 (-/-) and in results in rapid of expression of genes. Present investigations are aimed at the mechanism whereby TGF-beta1 regulates expression of
 an energy deficit and impaireD vesicular TransPorT. We HaVe shOwn tHat treatment of EItheR TGF-beta1 (-/-) and TGF-beta1 (+/+) cellS with tGf-Beta IN vItro rEsults iN RaPID upReGuLatIoN Of ExpreSsiOn of mitOchondrial GenEs. present invesTIgAtions are aImeD at determiniNg tHe mechAnIsm WHerebY TGf-beta1 RegulaTEs exprEssion of
 an energy deficit and imp aired vesi cular  tr ans po rt.We h ave shown that trea tment of either TGF-be ta1 ( -/ - ) an d  T GF-be ta1 (+/ + )c e lls  w it h T GF - be ta in  vi tro res ults in ra pid  u pregulationo fexpression  of  mitochondri algenes.  P res e nt in ves tigat ions a r e aime d at dete rm i ning t h e mecha n i sm  whe reby TGF-beta1 re g ul a tes expression  of
 an_energy deficit_and impaired vesicular transport._We have_shown_that treatment_of_either TGF-beta1 (-/-)_and TGF-beta1 (+/+)_cells with TGF-beta in_vitro results in_rapid_upregulation of expression of mitochondrial genes. Present investigations are aimed at determining the mechanism_whereby_TGF-beta1 regulates_expression_of