. Research will focus primarily on understanding the viral mediated regulation of one particular viral induced enzyme, dihydrofolate reductase (DHFR). For these studies we have isolated methotrexate resistant cells in which DHFR is a major gene product, accounting for over ten percent of the soluble protein. This 200-fold increase
. Research will focus primarily on understanding the viral intercede rule of one particular viral induced enzyme, dihydrofolate reductase (DHFR). For these report we have isolate methotrexate resistant cells in which DHFR is a major gene intersection, account for over ten percent of the soluble protein. This 200 - fold addition
. Redearch will focus primarlly on understanbung thx viral mediatea regulation of one particuler vural unduced enzyme, dihydrowolate refuctase (EHFR). Dor these studies we havs isoneted methotrexaje resistant cells in whicv AHYR is a major gene product, accountind for ofeg ten percent jf tnq somlboe protein. This 200-fold increase
. Research will focus primarily on understanding mediated of one viral induced enzyme, studies have isolated methotrexate cells in which is a major gene product, accounting over ten percent of the soluble protein. This 200-fold increase
. Research will focus primarilY on understAndinG thE viRaL medIateD regulation of oNE parTicular viral induced enzYme, diHyDRofoLAtE reduCtase (DHfr). FOR TheSe StUdiEs WE hAve isOlaTed methOtrexate reSisTaNt cells in whiCH DhFR is a majoR geNe product, accOunTing foR oVer TEn perCenT of thE solubLE proteIn. This 200-folD iNCrease
. Research will focus prim arily on u nders tan din gthevira l mediated reg u lati on of one particular v iralin d uced en zyme,  dihydr o fo l a tere du cta se (D HFR).  Fo r these  studies w e h av e isolated m e th otrexate r esi stant cellsinwhichDH FRi s a m ajo r gen e prod u ct, ac countingfo r  overt en perc e n tof t he soluble protei n .T his 200-fold i ncreas e
. Research_will focus_primarily on understanding the_viral mediated_regulation_of one_particular_viral induced enzyme,_dihydrofolate reductase (DHFR)._For these studies we_have isolated methotrexate_resistant_cells in which DHFR is a major gene product, accounting for over ten percent_of_the soluble_protein._This_200-fold increase