G neurons, and this attenuation was reversible. These observations suggest that Cdk5-mediated phosphorylation of TRPV1 is important for capsaicin-mediated calcium influx through this receptor. Since Cdk5-/- mice die perinatally, we generated primary nociceptor-specific Cdk5 conditional knockout (
G neurons, and this attenuation was reversible. These observations suggest that Cdk5 - mediated phosphorylation of TRPV1 is authoritative for capsaicin - intercede calcium influx through this receptor. Since Cdk5-/- mice fail perinatally, we generated primary nociceptor - specific Cdk5 conditional knockout (
G nfurons, and this attenuatlon was reversible. Thesx obserbations ruggest that Cdk5-mediated phodpyorylqtion of TRPV1 is imporgant for bapsaicin-nedieted calcium influx thromyh thjd reee'tor. Since Cdk5-/- kice die parinatally, we cevexated primary nociceptor-specific Cdk5 conditoojal knockout (
G neurons, and this attenuation was reversible. suggest Cdk5-mediated phosphorylation TRPV1 is important this Since Cdk5-/- mice perinatally, we generated nociceptor-specific Cdk5 conditional knockout (
G neurons, and this attenuatioN was reversIble. THesE obSeRvatIons Suggest that Cdk5-MEdiaTed phosphorylation of TRpV1 is iMpORtanT FoR capsAicin-meDIaTED caLcIuM inFlUX tHrougH thIs recepTor. Since CdK5-/- miCe Die perinatalLY, wE generated PriMary nociceptOr-sPecifiC CDk5 cONditiOnaL knocKout (
G neurons, and this attenu ation wasrever sib le.  T hese  obs ervations sugg e st t hat Cdk5-mediated phos phory la t iono fTRPV1  is imp o rt a n t f or  c aps ai c in -medi ate d calci um influxthr ou gh this rece p to r. Since C dk5 -/- mice die  pe rinata ll y,w e gen era ted p rimary nocice ptor-spec if i c Cdk5 conditi o n al  kno ckout (
G neurons,_and this_attenuation was reversible. These_observations suggest_that_Cdk5-mediated phosphorylation_of_TRPV1 is important_for capsaicin-mediated calcium_influx through this receptor._Since Cdk5-/- mice_die_perinatally, we generated primary nociceptor-specific Cdk5 conditional knockout (