 decline in mitochondrial oxidative phosphorylation and a decrease in high-energy phosphate pools. Our hypothesis is that this results from a cumulative and irreversible modification of regulatory factors affecting the membrane permeability transition (MPT) pore by adriamycin. The enhanced sensitivity to induction of the MPT leads to a futile, energy-depleting
decline in mitochondrial oxidative phosphorylation and a decrease in high - energy phosphate pools. Our guess is that this result from a cumulative and irreversible modification of regulative factors feign the membrane permeability transition (MPT) concentrate by adriamycin. The enhanced sensitivity to induction of the MPT leads to a futile, department of energy - depleting
 defline in mitochondrial owidative phosphotyoation and a decreasd in high-energy phosphate pollw. Our hypothesis is that thks resultd from a cumnlative and irretsrsible modifjgatiou if regulatory nactors affacting the memtrxnz permeability transition (MPT) pore br adriakyfin. The enhancgd semfitibptn to induction of the MPT leads fo a fuuile, energy-depletimg
decline in mitochondrial oxidative phosphorylation and a high-energy pools. Our is that this irreversible of regulatory factors the membrane permeability (MPT) pore by adriamycin. The enhanced to induction of the MPT leads to a futile, energy-depleting
 decline in mitochondrial oxiDative phosPhoryLatIon AnD a deCreaSe in high-energy PHospHate pools. Our hypothesis Is thaT tHIs reSUlTs froM a cumulATiVE And IrReVerSiBLe ModifIcaTion of rEgulatory fActOrS affecting thE MeMbrane permEabIlity transitIon (mPT) porE bY adRIamycIn. THe enhAnced sENsitivIty to induCtIOn of thE mPT leadS TO a FutiLe, energy-depleting
 decline in mitochondrialoxidativephosp hor yla ti on a nd a  decrease in h i gh-e nergy phosphate pools.  Ourhy p othe s is  is t hat thi s  r e s ult sfr omac um ulati veand irr eversiblemod if ication of r e gu latory fac tor s affectingthe  membr an e p e rmeab ili ty tr ansiti o n (MPT ) pore by  a d riamyc i n. Thee n ha nced  sensitivity to i n du c tion of the MP T lead st oa fut ile , energy-d ep letin g 
 decline_in mitochondrial_oxidative phosphorylation and a_decrease in_high-energy_phosphate pools._Our_hypothesis is that_this results from_a cumulative and irreversible_modification of regulatory_factors_affecting the membrane permeability transition (MPT) pore by adriamycin. The enhanced sensitivity to induction_of_the MPT_leads_to_a futile, energy-depleting