 reactive oxygen species. This hypothesis will be investigated by stretching both primary cultures of cat tracheal epithelial cells and human bronchial epithelial cells as well as lines of human bronchial epithelial cells grown on elastic membranes using a novel biaxial strain device. Preliminary results demonstrate that both cyclic mechanical elongation and compression delay wound closure by inhibiting cell
reactive oxygen species. This hypothesis will be investigated by stretching both basal acculturation of cat tracheal epithelial cells and human bronchial epithelial cells as well as line of human bronchial epithelial cells grown on elastic membrane use a novel biaxial stress device. Preliminary results demonstrate that both cyclic mechanical elongation and compaction delay wound closure by inhibiting cell
 rewctive oxygen species. Thls hypothesis will be iivestigzted by rtretching both primary cultnres of cqt tracheal epithelial cells anf human vronrhial epithelial cells as well ws lnnxs of human brokchial epitvelial cells gsodn on elastic membranes using a novel biaxiak dtrain device. Krelikynarg results demonstrate that both cydlic mebhanical elongatipn and compression delay wlund closure by inhibihing cell
reactive oxygen species. This hypothesis will be stretching primary cultures cat tracheal epithelial cells well as lines human bronchial epithelial grown on elastic membranes using a biaxial strain device. Preliminary results demonstrate that both cyclic mechanical elongation and compression wound closure by inhibiting cell
 reactive oxygen species. This Hypothesis Will bE inVesTiGateD by sTretching both pRImarY cultures of cat tracheal EpithElIAl ceLLs And huMan bronCHiAL EpiThElIal CeLLs As welL as Lines of Human broncHiaL ePithelial celLS gRown on elasTic Membranes usiNg a Novel bIaXiaL StraiN deVice. PRelimiNAry resUlts demonStRAte thaT Both cycLIC mEchaNical elongation anD CoMPression delay wOund clOsURe BY InhIbiTing cell
 reactive oxygen species.This hypot hesis  wi llbe  inv esti gated by stret c hing  both primary cultures  of c at trac h ea l epi thelial ce l l s a nd  h uma nb ro nchia l e pitheli al cells a s w el l as lines o f  h uman bronc hia l epithelial  ce lls gr ow n o n  elas tic  memb ranesu sing a  novel bi ax i al str a in devi c e .Prel iminary results d e mo n strate that bo th cyc li c  m e c han ica l elongati on  andc ompress i on d e lay wound closure  by inhibit i ngcell
 reactive_oxygen species._This hypothesis will be_investigated by_stretching_both primary_cultures_of cat tracheal_epithelial cells and_human bronchial epithelial cells_as well as_lines_of human bronchial epithelial cells grown on elastic membranes using a novel biaxial strain_device._Preliminary results_demonstrate_that_both cyclic mechanical elongation and_compression delay wound closure by_inhibiting cell