 of treatment on aerobic and hypoxic populations exposed simultaneously and to determine whether thermal enhancements are possible at MISO concentrations and pharmaco-kinetics achievable in the clinic. These later experiments will make use of a spheroid treatment device designed to permit pharmacokinetic modeling in vitro. Finally, the effect of heat on the chemopotent
of treatment on aerobic and hypoxic populations exposed simultaneously and to determine whether thermal enhancement are potential at MISO concentration and pharmaco - kinetics achievable in the clinic. These late experiments will make manipulation of a spheroid discussion device designed to permit pharmacokinetic modeling in vitro. Finally, the effect of heating system on the chemopotent
 of treatment on aerobic ana hypoxic populcrions xxposed simultaveously and to determine whevher thernal enhancements are pussible an MISO cobcenurations and pharmaco-kinebncs admievaylx in the clinic. These latar experiments wklp make use of a spheroid treatment qevice cedigned to permyt pnwrmadokinetic modeling in vitro. Finallg, the ehfect of heat om the chemopotent
of treatment on aerobic and hypoxic populations and determine whether enhancements are possible achievable the clinic. These experiments will make of a spheroid treatment device designed permit pharmacokinetic modeling in vitro. Finally, the effect of heat on the chemopotent
 of treatment on aerobic and hyPoxic populAtionS exPosEd SimuLtanEously and to detERminE whether thermal enhanceMents ArE PossIBlE at MIsO conceNTrATIonS aNd PhaRmACo-KinetIcs AchievaBle in the clIniC. THese later expERiMents will mAke Use of a spheroId tReatmeNt DevICe desIgnEd to pErmit pHArmacoKinetic moDeLIng in vITro. FinaLLY, tHe efFect of heat on the chEMoPOtent
 of treatment on aerobic a nd hypoxic  popu lat ion sexpo sedsimultaneously andto determine whether t herma le nhan c em entsare pos s ib l e  at  M IS O c on c en trati ons  and ph armaco-kin eti cs  achievablei nthe clinic . T hese later e xpe riment swil l  make  us e ofa sphe r oid tr eatment d ev i ce des i gned to p er mitpharmacokinetic m o de l ing in vitro.Finall y, th e eff ect  of heat o nthe c h emopote n t
 of_treatment on_aerobic and hypoxic populations_exposed simultaneously_and_to determine_whether_thermal enhancements are_possible at MISO_concentrations and pharmaco-kinetics achievable_in the clinic._These_later experiments will make use of a spheroid treatment device designed to permit pharmacokinetic_modeling_in vitro._Finally,_the_effect of heat on the_chemopotent