 substantial increase in both electroneutral Cl- absorption and HCO3- secretion in the CCD and increased mean arterial blood pressure. We hypothesize that NEDD4-2 associates with intercalated cell Cl- transporters such as pendrin and ClC-5, which leads to their ubiquitination, endocytosis and
substantial increase in both electroneutral Cl- absorption and HCO3- secretion in the CCD and increase base arterial blood pressure. We hypothesize that NEDD4 - 2 companion with intercalated cell Cl- transporters such as pendrin and ClC-5, which precede to their ubiquitination, endocytosis and
 suhstantial increase in bouh electroneutral Cl- absmrptioh and HCU3- secretion in the CCD and iicreqsed nean arterial blood prdssure. We hypothewize rhat NEDD4-2 easociatcf wifm intzrralated cell Cl- transportars such as petdfiu and ClC-5, which leads to their ubiquytinatipn, endocytosis agd
substantial increase in both electroneutral Cl- absorption secretion the CCD increased mean arterial NEDD4-2 with intercalated cell transporters such as and ClC-5, which leads to their endocytosis and
 substantial increase in both ElectroneuTral CL- abSorPtIon aNd HCo3- secretion in thE cCD aNd increased mean arteriaL blooD pREssuRE. WE hypoThesize THaT neDD4-2 AsSoCiaTeS WiTh intErcAlated cEll Cl- transPorTeRs such as pendRIn And ClC-5, whicH leAds to their ubIquItinatIoN, enDOcytoSis And
 substantial increase in b oth electr oneut ral  Cl -abso rpti on and HCO3- s e cret ion in the CCD and inc rease dm eana rt erial  bloodp re s s ure .We  hy po t he sizetha t NEDD4 -2 associa tes  w ith intercal a te d cell Cl-  tr ansporters s uch  as pe nd rin and C lC- 5, wh ich le a ds totheir ubi qu i tinati o n, endo c y to sisand
 substantial_increase in_both electroneutral Cl- absorption_and HCO3-_secretion_in the_CCD_and increased mean_arterial blood pressure._We hypothesize that NEDD4-2_associates with intercalated_cell_Cl- transporters such as pendrin and ClC-5, which leads to their ubiquitination, endocytosis and