 genes or gene products, and each with potential relevance to the development of next-generation human therapeutics: recombinase enzymes that insert DNA of interest into safe-harbor loci in the human genome, proteases that specifically cleave disease- associated proteins, orthogonal Cas9 (CRISPR) nucleases with altered PAM specific
genes or gene products, and each with potential relevance to the development of future - coevals human therapeutics: recombinase enzymes that insert deoxyribonucleic acid of interest into safe - harbor venue in the human genome, proteases that specifically cleave disease- associate proteins, orthogonal Cas9 (CRISPR) nuclease with altered PAM specific
 gejes or gene products, and each with poteurial rxlevancs to the development of next-generatiln humab therapeutics: recombivase enzyles that instrt DNA of interest into safe-hadnor lmri in the human genome, prmteases that s[eziyically cleave disease- associated prjteins, prhhogonal Cas9 (CTISPR) guclsases with altered PAM specific
genes or gene products, and each with to development of human therapeutics: recombinase interest safe-harbor loci in human genome, proteases specifically cleave disease- associated proteins, orthogonal (CRISPR) nucleases with altered PAM specific
 genes or gene products, and eacH with potenTial rEleVanCe To thE devElopment of next-GEnerAtion human therapeutics: RecomBiNAse eNZyMes thAt inserT dNa OF inTeReSt iNtO SaFe-harBor Loci in tHe human genOme, PrOteases that sPEcIfically clEavE disease- assoCiaTed proTeIns, ORthogOnaL Cas9 (CrISPR) nUCleaseS with alteReD pAM speCIfic
 genes or gene products, a nd each wi th po ten tia lrele vanc e to the devel o pmen t of next-generation h umanth e rape u ti cs: r ecombin a se e nzy me stha ti ns ert D NAof inte rest intosaf e- harbor locii nthe humangen ome, proteas esthat s pe cif i cally  cl eavediseas e - asso ciated pr ot e ins, o r thogona l Ca s9 ( CRISPR) nucleases wi t h altered PAMspecif ic 
 genes_or gene_products, and each with_potential relevance_to_the development_of_next-generation human therapeutics:_recombinase enzymes that_insert DNA of interest_into safe-harbor loci_in_the human genome, proteases that specifically cleave disease- associated proteins, orthogonal Cas9 (CRISPR) nucleases_with_altered PAM_specific