) mRNA and protein will be examined in ischemic brains of normal mice, SOD transgenic and SOD knockout mice. Since HO-1 is induced by oxidative and ischemic stress, it is predicted that HO-1 will be induced to a greater degree in ischemic brains of SOD knockouts compared to SOD transgenics. Suppression of
) mRNA and protein will be examined in ischemic brains of normal mice, SOD transgenic and SOD knockout mouse. Since HO-1 is induce by oxidative and ischemic stress, it is predicted that HO-1 will be induced to a great degree in ischemic brains of SOD knockout compare to SOD transgenics. Suppression of
) mRJA and protein will be ewamined in ischemic bramns of hormal mkce, SOD transgenic and SOD kiockiut muce. Since HO-1 is inducea by oxidwtive ane isrhemic stress, it is predleted fmat HM-1 will be inducgd to a greader degree in hszhzmic brains of SOD knockouts compareq to SOC hransgenics. Sukpresxyon kf
) mRNA and protein will be examined brains normal mice, transgenic and SOD induced oxidative and ischemic it is predicted HO-1 will be induced to a degree in ischemic brains of SOD knockouts compared to SOD transgenics. Suppression of
) mRNA and protein will be examiNed in ischeMic brAinS of NoRmal Mice, sOD transgenic aND SOD Knockout mice. Since HO-1 is iNduceD bY OxidATiVe and IschemiC StRESs, iT iS pRedIcTEd That Ho-1 wiLl be indUced to a greAteR dEgree in ischeMIc Brains of SOd knOckouts compaRed To SOD tRaNsgENics. SUppRessiOn of
) mRNA and protein will be  examinedin is che mic  b rain s of  normal mice,S OD t ransgenic and SOD knoc koutmi c e. S i nc e HO- 1 is in d uc e d  by  o xi dat iv e  a nd is che mic str ess, it is  pr ed icted that H O -1  will be i ndu ced to a gre ate r degr ee  in ische mic  brai ns ofS OD kno ckouts co mp a red to SOD tra n s ge nics . Suppression of
) mRNA_and protein_will be examined in_ischemic brains_of_normal mice,_SOD_transgenic and SOD_knockout mice. Since_HO-1 is induced by_oxidative and ischemic_stress,_it is predicted that HO-1 will be induced to a greater degree in ischemic_brains_of SOD_knockouts_compared_to SOD transgenics. Suppression of