 recombination, may involve DSBs and thus, employ NHEJ. We have shown that defective NHEJ during attempted V(D)J recombination in a p53 tumor-suppressor deficient background reproducibly leads to murine pro-B cell lymphomas that harbor translocations between the IgH and c-myc
recombination, may involve DSBs and thus, employ NHEJ. We have shown that bad NHEJ during try V(D)J recombination in a p53 tumor - suppressor deficient background reproducibly lead to murine pro - B cellular telephone lymphomas that harbor translocations between the IgH and c - myc
 refombination, may involve ASBs and thus, employ NIEJ. We gave shodn that defective NHEJ durinj atrempttb V(D)J recombination kn a p53 tulor-supprwssoc deficient backjdound rc'rodudlbly nxads to murine kro-B cell lykphomas that hdrcox translocations between the IgH and c-myc
recombination, may involve DSBs and thus, employ have that defective during attempted V(D)J deficient reproducibly leads to pro-B cell lymphomas harbor translocations between the IgH and
 recombination, may involve DSbs and thus, eMploy nHEj. We HaVe shOwn tHat defective NHej durIng attempted V(D)J recombiNatioN iN A p53 tuMOr-SupprEssor deFIcIENt bAcKgRouNd REpRoducIblY leads tO murine pro-b ceLl Lymphomas thaT HaRbor translOcaTions between The igH and C-mYc
 recombination, may involv e DSBs and  thus , e mpl oy  NHE J. W e have shown t h at d efective NHEJ during a ttemp te d  V(D ) Jrecom binatio n  i n a p 53  t umo r- s up press ordeficie nt backgro und  r eproduciblyl ea ds to muri nepro-B cell l ymp homasth ath arbor  tr anslo cation s  betwe en the Ig Ha nd c-m y c
 recombination,_may involve_DSBs and thus, employ_NHEJ. We_have_shown that_defective_NHEJ during attempted_V(D)J recombination in_a p53 tumor-suppressor deficient_background reproducibly leads_to_murine pro-B cell lymphomas that harbor translocations between the IgH and c-myc