 and 11, which are the least well characterized of the metal-dependent HDACs. Our preliminary studies coupled with phylogenetic comparisons suggest that HDACs 10 and 11 may function as dual acetyllysine and acetylpolyamine deacetylases with unique substrate binding site architectures. However, how HDAC10 and 11 could accommodate small polyamine
and 11, which are the least well characterized of the metal - dependent HDACs. Our preliminary studies pair with phylogenetic comparison suggest that HDACs 10 and 11 may function as dual acetyllysine and acetylpolyamine deacetylases with singular substrate binding site computer architecture. However, how HDAC10 and 11 could oblige small polyamine
 anf 11, which are the least wtll characterized of the metal-sependeng HDACs. Our preliminary studmes xoupltb with phylogenetic zomparisojs suggewt tiat HDACs 10 and 11 may funcbnon aa duan acetyllysine snd acetyl[olyamine deacathlcses with unique substrate binding syte arcnihectures. Howevgr, hoe HDAD10 and 11 could accommodate small polgamine
and 11, which are the least well the HDACs. Our studies coupled with 10 11 may function dual acetyllysine and deacetylases with unique substrate binding site However, how HDAC10 and 11 could accommodate small polyamine
 and 11, which are the least well chAracterizeD of thE meTal-DePendEnt HdACs. Our prelimiNAry sTudies coupled with phyloGenetIc COmpaRIsOns suGgest thAT Hdacs 10 aNd 11 MaY fuNcTIoN as duAl aCetyllySine and aceTylPoLyamine deaceTYlAses with unIquE substrate biNdiNg site ArChiTEcturEs. HOweveR, how HDac10 and 11 coUld accommOdATe smalL PolyamiNE
 and 11, which are the lea st well ch aract eri zed  o f th e me tal-dependentH DACs . Our preliminary stud ies c ou p ledw it h phy logenet i cc o mpa ri so nssu g ge st th atHDACs 1 0 and 11 m ayfu nction as du a lacetyllysi neand acetylpo lya mine d ea cet y lases  wi th un ique s u bstrat e binding  s i te arc h itectur e s .Howe ver, how HDAC10 a n d1 1 could accomm odatesm a ll p oly ami ne
 and_11, which_are the least well_characterized of_the_metal-dependent HDACs._Our_preliminary studies coupled_with phylogenetic comparisons_suggest that HDACs 10_and 11 may_function_as dual acetyllysine and acetylpolyamine deacetylases with unique substrate binding site architectures. However, how_HDAC10_and 11_could_accommodate_small polyamine