, selected high priority candidate substrates and the corresponding F-box adaptor proteins will be analyzed through biochemical and cell biological methods to place these proteins into regulatory and physiological pathways with an initial focus on a BACH1, a signal-dependent transcriptional repressor of NRF2-dependent genes and a novel substrate of SCFF
, selected high priority candidate substrate and the correspond F - box adaptor proteins will be analyzed through biochemical and cellular telephone biological methods to place these proteins into regulative and physiologic pathways with an initial focus on a BACH1, a signal - dependent transcriptional repressor of NRF2 - dependent genes and a fresh substrate of SCFF
, sepected high priority canaidate substratgs and tie corrsspondine F-box adaptor proteins will bw anaoyzed through biochemizal and cvll bioloticao methods to place bkese lvoteius into regulatoty and physimlogical pathwdyr cith an initial focus on a BACH1, a sidnal-deprnfent transcripjionak repdvswor of NRF2-dependent genes and a noven substrate og SCFF
, selected high priority candidate substrates and F-box proteins will analyzed through biochemical place proteins into regulatory physiological pathways with initial focus on a BACH1, a transcriptional repressor of NRF2-dependent genes and a novel substrate of SCFF
, selected high priority candiDate substrAtes aNd tHe cOrRespOndiNg F-box adaptor pROteiNs will be analyzed througH biocHeMIcal ANd Cell bIologicAL mETHodS tO pLacE tHEsE protEinS into reGulatory anD phYsIological patHWaYs with an inItiAl focus on a BAcH1, a Signal-DePenDEnt trAnsCriptIonal rEPressoR of NRF2-depEnDEnt genES and a noVEL sUbstRate of SCFF
, selected high priority c andidate s ubstr ate s a nd  the  cor responding F-b o x ad aptor proteins will be  anal yz e d th r ou gh bi ochemic a la n d c el lbio lo g ic al me tho ds to p lace these  pr ot eins into re g ul atory andphy siological p ath ways w it h a n  init ial  focu s on a BACH1,  a signal -d e penden t  transc r i pt iona l repressor of NR F 2- d ependent genes  and a  n o ve l sub str ate of SCF F
, selected_high priority_candidate substrates and the_corresponding F-box_adaptor_proteins will_be_analyzed through biochemical_and cell biological_methods to place these_proteins into regulatory_and_physiological pathways with an initial focus on a BACH1, a signal-dependent transcriptional repressor of_NRF2-dependent_genes and_a_novel_substrate of SCFF