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on a genome-wide scale in the context chromatin With this aspects of gene in to transcription factor and the transcriptional of histone modifications. These studies are to shed light on two fundamental questions in gene regulation: Can transcription factors access their binding sites in native
 on a genome-wide scale in the coNtext of proPer chRomAtiN sTrucTure. with this assay aSPectS of gene expression regulAtion WiLL be iNVeStigaTed in reGArDS To tRaNsCriPtIOn FactoR biNding anD the transcRipTiOnal requiremENtS of histone ModIfications. ThEse StudieS aRe iNTendeD to Shed lIght on TWo fundAmental quEsTIons in GEne reguLATiOn: CaN transcription facTOrS Intrinsically aCcess tHeIR bINDinG siTes in nativE
 on a genome-wide scale in  the conte xt of  pr ope rchro mati n structure. W i th t his assay aspects of g ene e xp r essi o nregul ation w i ll b e i nv es tig at e din re gar ds to t ranscripti onfa ctor binding an d the tran scr iptional req uir ements  o f h i stone  mo dific ations .  These  studiesar e  inten d ed to s h e dligh t on two fundamen t al questions in g ene re gu l at i o n:Can  transcrip ti on fa c tors in t ri n s i cal l y access thei r binding s i tes  in na ti ve
 on_a genome-wide_scale in the context_of proper_chromatin_structure. With_this_assay aspects of_gene expression regulation_will be investigated in_regards to transcription_factor_binding and the transcriptional requirements of histone modifications. These studies are intended to shed_light_on two_fundamental_questions_in gene regulation: Can transcription_factors intrinsically access their binding_sites in_native