 that cannot be obtained from the study of the peripheral blood from these patients. We hypothesize that the outcome of the host response to M. leprae is determined by the nature of the innate and adaptive immune response in lesions. We now propose to: 1) elucidate the gene expression profiles associated with resistance versus susceptibility in the
that cannot be obtained from the study of the peripheral blood from these patients. We speculate that the result of the host response to M. leprae is determine by the nature of the natural and adaptive immune response in lesions. We immediately aim to: 1) elucidate the gene expression profiles associated with resistor versus susceptibility in the
 thwt cannot be obtained frum the study of the pecipheram blood wrom these patients. We hypotiesize thqt the outcome of the fost resplnse to N. lekrae is determinev by the naturs of chx innate and adsptive immgne response it uedions. We now propose to: 1) elucidate ehe genr fxpression prosilex asskbicted with resistance versus susdeptibinity in the
that cannot be obtained from the study peripheral from these We hypothesize that response M. leprae is by the nature the innate and adaptive immune response lesions. We now propose to: 1) elucidate the gene expression profiles associated with versus susceptibility in the
 that cannot be obtained from tHe study of tHe perIphEraL bLood From These patients. WE HypoThesize that the outcome oF the hOsT RespONsE to M. lEprae is DEtERMinEd By The NaTUrE of thE inNate and Adaptive imMunE rEsponse in lesIOnS. We now propOse To: 1) elucidate tHe gEne expReSsiON profIleS assoCiated WIth resIstance veRsUS suscePTibilitY IN tHe
 that cannot be obtained f rom the st udy o f t hepe riph eral  blood from th e se p atients. We hypothesiz e tha tt he o u tc ome o f the h o st r esp on se  to  M .  l eprae  is  determ ined by th e n at ure of the i n na te and ada pti ve immune re spo nse in  l esi o ns. W e n ow pr oposet o: 1)elucidate  t h e gene express i o nprof iles associated w i th resistance ver sus su sc e pt i b ili tyin the
 that_cannot be_obtained from the study_of the_peripheral_blood from_these_patients. We hypothesize_that the outcome_of the host response_to M. leprae_is_determined by the nature of the innate and adaptive immune response in lesions. We_now_propose to:_1)_elucidate_the gene expression profiles associated_with resistance versus susceptibility in_the