 ion transport proteins. The general functional properties of most Na+ transport proteins are understood. However, it is not clear what contribution individual Na+ transport proteins make to the overall secretion process, or which compensatory mechanisms may arise if the activity of a given transporter is perturbed. Thus, Aim 1 will determine which Na+ transport mechanisms
ion transport proteins. The general functional place of most Na+ ecstasy proteins are understood. However, it is not clear what contribution individual Na+ transportation proteins make to the overall secretion summons, or which compensatory mechanism may arise if the action of a given transporter is perturb. Thus, Aim 1 will decide which Na+ tape drive mechanisms
 ioj transport proteins. The general functional prmpertiss of mort Na+ transport proteins are ubdersujod. However, it is vot clear what cobtriuution individual Na+ trakfporf procemns make to the overall sacretion procevs, ox which compensatory mechanisms may wrise ig hhe activity os a byven nrcnsporter is perturbed. Thus, Aim 1 will vetermine which Na+ transport mechanisms
ion transport proteins. The general functional properties Na+ proteins are However, it is Na+ proteins make to overall secretion process, which compensatory mechanisms may arise if activity of a given transporter is perturbed. Thus, Aim 1 will determine which transport mechanisms
 ion transport proteins. The geNeral functIonal ProPerTiEs of Most na+ transport proTEins Are understood. However, it Is not ClEAr whAT cOntriBution iNDiVIDuaL NA+ tRanSpORt ProteIns Make to tHe overall sEcrEtIon process, or WHiCh compensaTorY mechanisms mAy aRise if ThE acTIvity Of a Given TranspORter is Perturbed. thUS, Aim 1 wiLL determINE wHich na+ transport mechanISmS
 ion transport proteins. T he general  func tio nal  p rope rtie s of most Na+t rans port proteins are unde rstoo d. Howe v er , itis notc le a r  wh at  c ont ri b ut ion i ndi vidualNa+ transp ort  p roteins make to  the overa llsecretion pr oce ss, or  w hic h  comp ens atory  mecha n isms m ay ariseif the ac t ivity o f agive n transporter isp er t urbed. Thus, A im 1 w il l  d e t erm ine  which Na+  t ransp o rt mech a ni s m s 
 ion_transport proteins._The general functional properties_of most_Na+_transport proteins_are_understood. However, it_is not clear_what contribution individual Na+_transport proteins make_to_the overall secretion process, or which compensatory mechanisms may arise if the activity of_a_given transporter_is_perturbed._Thus, Aim 1 will determine_which Na+ transport mechanisms