, and the excitatory neurotransmitter glutamate. The quantitative neuroanatomic analyses rely on computer-assisted microscopy and involve studies of cell distribution as well as morphologic and intracellular characteristics of individual neurons. An important underlying assumption in this proposal is that the selective vulnerability in Alzheimer's Disease is related to the molecular and anatomic heterogeneity of
, and the excitatory neurotransmitter glutamate. The quantitative neuroanatomic analyses rely on computer - assisted microscopy and imply cogitation of cell distribution equally well as morphologic and intracellular characteristic of individual neurons. An important implicit in assumption in this proposal is that the selective vulnerability in Alzheimer's Disease is associate to the molecular and anatomic heterogeneity of
, anf the excitatory neurotrxnsmitter glutamate. Thx quantjtative veuroanatomic analyses rely ln compyter-assisted microscoph and invllve stueies if cell distribution as scll av morphologic akd intracelnular charactesirtncs of individual neurons. An importagt undetljing assumptiog in ehis iriposal is that the selective bulnerauility in Alzheomer's Disease is related tl thf molecular and anwtomic hetetkgegwity of
, and the excitatory neurotransmitter glutamate. The analyses on computer-assisted and involve studies as and intracellular characteristics individual neurons. An underlying assumption in this proposal is the selective vulnerability in Alzheimer's Disease is related to the molecular and anatomic of
, and the excitatory neurotranSmitter gluTamatE. ThE quAnTitaTive Neuroanatomic aNAlysEs rely on computer-assistEd micRoSCopy ANd InvolVe studiES oF CEll DiStRibUtIOn As welL as MorpholOgic and intRacElLular charactERiStics of indIviDual neurons. AN imPortanT uNdeRLying AssUmptiOn in thIS propoSal is that ThE SelectIVe vulneRABiLity In Alzheimer's DiseaSE iS Related to the moLeculaR aND aNATomIc hEterogeneiTy Of
, and the excitatory neuro transmitte r glu tam ate .Thequan titative neuro a nato mic analyses rely on c omput er - assi s te d mic roscopy an d inv ol ve  st ud i es  of c ell  distri bution aswel las morpholog i cand intrac ell ular charact eri sticsof  in d ividu alneuro ns. An import ant under ly i ng ass u mptioni n  t hisproposal is thatt he selective vuln erabil it y  i n Alz hei mer's Dise as e isr elatedt ot h e  mo l ecular and an atomic hete r oge neityof 
, and_the excitatory_neurotransmitter glutamate. The quantitative_neuroanatomic analyses_rely_on computer-assisted_microscopy_and involve studies_of cell distribution_as well as morphologic_and intracellular characteristics_of_individual neurons. An important underlying assumption in this proposal is that the selective vulnerability_in_Alzheimer's Disease_is_related_to the molecular and anatomic_heterogeneity of