 of NAFLD. Our preliminary studies identified the MAP3K mixed-lineage kinase 3 (MLK3) as an important mediator of saturated FFA- induced JNK signaling. Thus, we have demonstrated that MLK3 mediates FFA-induced JNK activation, promotes obesity-induced insulin resistance and modulates FFA-
of NAFLD. Our preliminary studies identified the MAP3 K mixed - lineage kinase 3 (MLK3) as an authoritative mediator of saturated FFA- induce JNK signaling. Thus, we have demonstrated that MLK3 mediates FFA - induce JNK activation, promotes fleshiness - induced insulin resistance and modulates FFA-
 of NAFLD. Our preliminary suudies identified the MA'3K mixes-lineage kinase 3 (MLK3) as an important mwdiatir of saturated FFA- inauced JNK signalibg. Tius, we have demoiatrated that JPK3 mzdmates FFA-inducec JNK actieation, promotev ubzsity-induced insulin resistance and iodulatrs FFA-
of NAFLD. Our preliminary studies identified the kinase (MLK3) as important mediator of Thus, have demonstrated that mediates FFA-induced JNK promotes obesity-induced insulin resistance and modulates
 of NAFLD. Our preliminary studIes identifIed thE MAp3K mIxEd-liNeagE kinase 3 (MLK3) as an IMporTant mediator of saturateD FFA- iNdUCed Jnk sIgnalIng. Thus, WE hAVE deMoNsTraTeD ThAt MLK3 MedIates FFa-induced JNk acTiVation, promotES oBesity-induCed Insulin resisTanCe and mOdUlaTEs FFA-
 of NAFLD. Our preliminary  studies i denti fie d t he  MAP 3K m ixed-lineage k i nase  3 (MLK3) as an import ant m ed i ator of  satu rated F F A- i ndu ce dJNK  s i gn aling . T hus, we  have demo nst ra ted that MLK 3  m ediates FF A-i nduced JNK a cti vation ,pro m otesobe sity- induce d  insul in resist an c e andm odulate s FF A-
 of_NAFLD. Our_preliminary studies identified the_MAP3K mixed-lineage_kinase_3 (MLK3)_as_an important mediator_of saturated FFA-_induced JNK signaling. Thus,_we have demonstrated_that_MLK3 mediates FFA-induced JNK activation, promotes obesity-induced insulin resistance and modulates FFA-