 neuron in vivo. Aim 1. This project will determine the mechanism of de novo VP16 gene activation and silencing in sensory neurons in vivo. The working hypothesis is that the VP16 gene in the HSV-1 genome can be regulated by action of neuron-specific and stress-responsive promoter elements and corresponding transcription factors either to
neuron in vivo. Aim 1. This project will determine the mechanism of de novo VP16 gene activation and hush in centripetal neurons in vivo. The working hypothesis is that the VP16 gene in the HSV-1 genome can be regulate by action of neuron - specific and tension - responsive promoter elements and comparable arrangement factors either to
 nekron in vivo. Aim 1. This pvoject will detetmune thx mechahism of ae novo VP16 gene activation aid sulencung in sensory neurons in vivo. Nhe workibg hbpothesis is thav the VP16 gene jk the ISV-1 genome can ne regulateg by action of nduxon-specific and stress-responsive proioter ekelents and corrgsponcyng fgakscription factors either to
neuron in vivo. Aim 1. This project the of de VP16 gene activation in The working hypothesis that the VP16 in the HSV-1 genome can be by action of neuron-specific and stress-responsive promoter elements and corresponding transcription factors either
 neuron in vivo. Aim 1. This projecT will deterMine tHe mEchAnIsm oF de nOvo VP16 gene activATion And silencing in sensory nEuronS iN Vivo. tHe WorkiNg hypotHEsIS Is tHaT tHe Vp16 gENe In the hSV-1 Genome cAn be regulaTed By Action of neurON-sPecific and StrEss-responsivE prOmoter ElEmeNTs and CorRespoNding tRAnscriPtion factOrS Either TO
 neuron in vivo. Aim 1. Th is project  will  de ter mi ne t he m echanism of de novo  VP16 gene activationand s il e ncin g  i n sen sory ne u ro n s  in  v iv o.Th e  w orkin g h ypothes is is that  th eVP16 gene in th e HSV-1 ge nom e can be reg ula ted by  a cti o n ofneu ron-s pecifi c  and s tress-res po n sive p r omotere l em ents  and correspondin g  t r anscription fa ctorsei t he r to
 neuron_in vivo._Aim 1. This project_will determine_the_mechanism of_de_novo VP16 gene_activation and silencing_in sensory neurons in_vivo. The working_hypothesis_is that the VP16 gene in the HSV-1 genome can be regulated by action_of_neuron-specific and_stress-responsive_promoter_elements and corresponding transcription factors_either to