 Y2 receptor antagonists (Aim 2A). Previous studies indicate that inflammation up-regulates the expression of NPY and Y1 in the arcuate nucleus of the hypothalamus (ARC), and that microinjection of NPY into the ARC attenuated behavioral signs of heat hypersensitivity. In Aim 2B, I propose to
Y2 receptor antagonists (Aim 2A). Previous studies bespeak that excitement up - regulates the expression of NPY and Y1 in the arcuate lens nucleus of the hypothalamus (ARC), and that microinjection of NPY into the ARC attenuated behavioral signs of hotness hypersensitivity. In Aim 2B, I propose to
 Y2 geceptor antagonists (Aim 2A). Previous stubues invicate fhat infuammation up-regulates the ex'reswion if NPY and Y1 in the arzuate nucpeus of rhe iypothalamus (ARC), and thab micdlinjzcvion of NPY intp the ARC dttenuated behdvkoxal signs of heat hypersensitivity. Ig Aim 2B, I propose to
Y2 receptor antagonists (Aim 2A). Previous studies inflammation the expression NPY and Y1 the (ARC), and that of NPY into ARC attenuated behavioral signs of heat In Aim 2B, I propose to
 Y2 receptor antagonists (Aim 2A). PRevious stuDies iNdiCatE tHat iNflaMmation up-regulATes tHe expression of NPY and Y1 iN the aRcUAte nUClEus of The hypoTHaLAMus (aRc), aNd tHaT MiCroinJecTion of NpY into the ArC aTtEnuated behavIOrAl signs of hEat HypersensitiVitY. In Aim 2b, I ProPOse to
 Y2 receptor antagonists ( Aim 2A). P revio usstu di es i ndic ate that infla m mati on up-regulates the ex press io n  ofN PY  andY1 in t h ea r cua te  n ucl eu s  o f the  hy pothala mus (ARC),  an dthat microin j ec tion of NP Y i nto the ARCatt enuate dbeh a viora l s ignsof hea t  hyper sensitivi ty .  In Ai m  2B, Ip r op oseto
 Y2_receptor antagonists_(Aim 2A). Previous studies_indicate that_inflammation_up-regulates the_expression_of NPY and_Y1 in the_arcuate nucleus of the_hypothalamus (ARC), and_that_microinjection of NPY into the ARC attenuated behavioral signs of heat hypersensitivity. In Aim_2B,_I propose_to