. In AIM 1, the investigators will study the molecular mechanisms underlying perturbed protein homeostasis in a well-established mouse model for mitochondrial FAO disorders. For this they will determine the dynamics of metabolic signaling during fasting in liver, heart and skeletal muscle and will quantify metabolic fluxes in protein synthesis and degradation. They will use a
. In AIM 1, the investigators will study the molecular mechanisms underlying perturb protein homeostasis in a well - prove mouse model for mitochondrial FAO disorders. For this they will decide the dynamics of metabolic signaling during fast in liver, kernel and skeletal muscle and will quantify metabolic fluxes in protein synthesis and abasement. They will use a
. In AIM 1, the investigators dill study the moleculer mechznisms uvderlying perturbed protein iomeistasus in a well-establishea mouse mldel for mitixhondrial HZO disovbers. Rlr tkiw they will dejermine the gynamics of medacopic signaling during fasting in livqr, heary wnd skeletal moscle wnd splo quantify metabolic fluxes ih protepn synthesis and cegradation. They will use w
. In AIM 1, the investigators will molecular underlying perturbed homeostasis in a FAO For this they determine the dynamics metabolic signaling during fasting in liver, and skeletal muscle and will quantify metabolic fluxes in protein synthesis and degradation. will use a
. In AIM 1, the investigators will Study the moLeculAr mEchAnIsms UndeRlying perturbeD ProtEin homeostasis in a well-eStablIsHEd moUSe Model For mitoCHoNDRiaL FaO DisOrDErS. For tHis They wilL determine The DyNamics of metaBOlIc signalinG duRing fasting iN liVer, heaRt And SKeletAl mUscle And wilL QuantiFy metabolIc FLuxes iN Protein SYNtHesiS and degradation. ThEY wILl use a
. In AIM 1, the investigat ors will s tudythe  mo le cula r me chanisms under l ying  perturbed protein hom eosta si s  ina  w ell-e stablis h ed m ous emo del  f o rmitoc hon drial F AO disorde rs.  F or this they wi ll determi nethe dynamics  of  metab ol ics ignal ing  duri ng fas t ing in  liver, h ea r t ands keletal m us cleand will quantify me t abolic fluxesin pro te i ns y nth esi s and degr ad ation .  They w i ll u s e a 
. In_AIM 1,_the investigators will study_the molecular_mechanisms_underlying perturbed_protein_homeostasis in a_well-established mouse model_for mitochondrial FAO disorders._For this they_will_determine the dynamics of metabolic signaling during fasting in liver, heart and skeletal muscle_and_will quantify_metabolic_fluxes_in protein synthesis and degradation._They will use a