. We have chosen five treatments that known to induce closure of Cx26 channels or hemichannels and are physiologically relevant. Conformational changes identified by AFM imaging will be further imaged using EM. Each of these goals is intended to complement the others and lead to structural and ph),siolo_ical models of Cx
. We have chosen five treatments that known to induce closure of Cx26 groove or hemichannels and are physiologically relevant. Conformational change identified by AFM imagination will be further visualize using EM. Each of these goals is intend to complement the others and lead to structural and ph),siolo_ical model of Cx
. We have chosen five treatmtnts that known to inducx closude of Cx26 channels or hemichannels anv arw phywiologically relevant. Zonformatponal chabges udentified by AFM liagihn wiln be further imsged using EM. Each of thasd yoals is intended to complement the jthers snf lead to strustursj ans ph),siolo_ical models of Cx
. We have chosen five treatments that induce of Cx26 or hemichannels and identified AFM imaging will further imaged using Each of these goals is intended complement the others and lead to structural and ph),siolo_ical models of Cx
. We have chosen five treatmentS that known To indUce CloSuRe of cx26 chAnnels or hemichANnelS and are physiologically RelevAnT. confORmAtionAl changES iDENtiFiEd By AfM IMaGing wIll Be furthEr imaged usIng eM. each of these gOAlS is intendeD to Complement thE otHers anD lEad TO struCtuRal anD ph),sioLO_ical mOdels of Cx
. We have chosen five trea tments tha t kno wntoin duce  clo sure of Cx26 c h anne ls or hemichannels and  areph y siol o gi cally  releva n t. C onf or ma tio na l  c hange s i dentifi ed by AFMima gi ng will be f u rt her imaged  us ing EM. Each  of  these  g oal s  is i nte ndedto com p lement  the othe rs and le a d to st r u ct ural  and ph),siolo_ic a lm odels of Cx
. We_have chosen_five treatments that known_to induce_closure_of Cx26_channels_or hemichannels and_are physiologically relevant._Conformational changes identified by_AFM imaging will_be_further imaged using EM. Each of these goals is intended to complement the others_and_lead to_structural_and_ph),siolo_ical models of Cx