. A basic understanding of the nature of keratin modification in MB should allow designing rational experiments to determine if changes in keratins are essential for alcohol induced injury and if such changes can be reversed. Our hypothesis is that Mallory Body formation may result from alterations in glycosylation and/or phosphorylation of hepatocyte keratins
. A basic understanding of the nature of keratin modification in MB should allow design intellectual experiments to determine if change in keratin are essential for alcohol induced injury and if such change can be reversed. Our hypothesis is that Mallory Body constitution may result from alterations in glycosylation and/or phosphorylation of hepatocyte keratin
. A hasic understanding of tme nature of kercrin movificatjon in MC should allow designing ratmonao exptgiments to determine kf changed in kerqtinw are essenvjal for alcohkp inbured injury and lf such chatges can be reeefszd. Our hypothesis is that Mallory Boqy formstlon may result frok altsgauions in glycosylation and/or phoslhorylauion of hepatocyte keratins
. A basic understanding of the nature modification MB should designing rational experiments keratins essential for alcohol injury and if changes can be reversed. Our hypothesis that Mallory Body formation may result from alterations in glycosylation and/or phosphorylation of keratins
. A basic understanding of the nAture of kerAtin mOdiFicAtIon iN MB sHould allow desiGNing Rational experiments to dEtermInE If chANgEs in kEratins ARe ESSenTiAl For AlCOhOl indUceD injury And if such cHanGeS can be reversED. OUr hypothesIs iS that Mallory bodY formaTiOn mAY resuLt fRom alTeratiONs in glYcosylatiOn ANd/or phOSphorylATIoN of hEpatocyte keratins
. A basic understanding of  the natur e ofker ati nmodi fica tion in MB sho u ld a llow designing rationa l exp er i ment s  t o det erminei fc h ang es  i n k er a ti ns ar e e ssentia l for alco hol  i nduced injur y  a nd if such  ch anges can be  re versed .Our hypot hes is is  thatM allory  Body for ma t ion ma y  result f ro m al terations in glyc o sy l ation and/or p hospho ry l at i o n o f h epatocyteke ratin s 
. A_basic understanding_of the nature of_keratin modification_in_MB should_allow_designing rational experiments_to determine if_changes in keratins are_essential for alcohol_induced_injury and if such changes can be reversed. Our hypothesis is that Mallory Body_formation_may result_from_alterations_in glycosylation and/or phosphorylation of_hepatocyte keratins