 contribute to development of chronic inflammatory diseases. Importantly, these pathogenic mechanisms allow the integration of environmental factors and genetic susceptibility loci that together contribute to the development of some of the most common chronic diseases, including type 2 diabetes, asthma, inflammatory bowel disease and chronic liver disease. In the previous grant period we have generated strong evidence in
contribute to development of chronic inflammatory diseases. Importantly, these infective mechanism allow the integration of environmental divisor and genic susceptibility loci that together put up to the exploitation of some of the most coarse chronic diseases, including character 2 diabetes, asthma, inflammatory bowel disease and chronic liver disease. In the previous grant time period we have generated strong evidence in
 cojtribute to development uf chronic inflcnmatorb diseaaes. Impoftantly, these pathogenic mecianiwms aolow the integration ow environlental fqctocs and genetic snaceptibljity poci vhat together cpntribute do the developkevt of some of the most common chronic diseasrs, including typg 2 disfetea, asthma, inflammatory bowel diseass and cironic liver dixease. In the previous granh pegiod we have generwted strong eviqwnce in
contribute to development of chronic inflammatory diseases. pathogenic allow the of environmental factors together to the development some of the common chronic diseases, including type 2 asthma, inflammatory bowel disease and chronic liver disease. In the previous grant period have generated strong evidence in
 contribute to development of Chronic infLammaTorY diSeAses. impoRtantly, these paTHogeNic mechanisms allow the iNtegrAtIOn of ENvIronmEntal faCToRS And GeNeTic SuSCePtibiLitY loci thAt together ConTrIbute to the deVElOpment of soMe oF the most commOn cHronic DiSeaSEs, incLudIng tyPe 2 diabETes, astHma, inflamMaTOry bowEL diseasE ANd ChroNic liver disease. In THe PRevious grant peRiod we HaVE gENEraTed Strong evidEnCe in
 contribute to development  of chroni c inf lam mat or y di seas es. Importantl y , th ese pathogenic mechani sms a ll o w th e  i ntegr ation o f  e n v iro nm en tal  f a ct ors a ndgenetic  susceptib ili ty  loci that t o ge ther contr ibu te to the de vel opment  o f s o me of  th e mos t comm o n chro nic disea se s , incl u ding ty p e  2  dia betes, asthma, in f la m matory bowel d isease  a n dc h ron icliver dise as e. In the pre v io u s gra n t period we h ave generat e d s trongev ide n ce in
 contribute_to development_of chronic inflammatory diseases._Importantly, these_pathogenic_mechanisms allow_the_integration of environmental_factors and genetic_susceptibility loci that together_contribute to the_development_of some of the most common chronic diseases, including type 2 diabetes, asthma, inflammatory_bowel_disease and_chronic_liver_disease. In the previous grant_period we have generated strong_evidence in