 degradation. We hypothesize further that aldosterone increases Cl- absorption in the CCD, in part, by reducing the association of these transporters with NEDD4-2. This proposal will dissect the mechanism whereby intercalated cell NEDD4-2 alters Cl- transport by intercalated cells. Aims
degradation. We hypothesize further that aldosterone increases Cl- concentration in the CCD, in character, by reducing the association of these transporters with NEDD4 - 2. This marriage proposal will dissect the mechanism whereby intercalated cell NEDD4 - 2 alters Cl- transportation by intercalated cells. Aims
 dehradation. We hypothesize further that aldostermne indreases Zl- absorption in the CCD, in 'art, by rtbucing the associatiun of thede transporttrs with NEDD4-2. This proposal wilm disvxct the mechanixm whereby intercalated weul NEDD4-2 alters Cl- transport by intercwlated vepls. Aims
degradation. We hypothesize further that aldosterone increases in CCD, in by reducing the NEDD4-2. proposal will dissect mechanism whereby intercalated NEDD4-2 alters Cl- transport by intercalated Aims
 degradation. We hypothesize fUrther that AldosTerOne InCreaSes CL- absorption in tHE CCD, In part, by reducing the assOciatIoN Of thESe TransPorters WItH neDD4-2. thIs ProPoSAl Will dIssEct the mEchanism whEreBy Intercalated CElL NEDD4-2 alterS Cl- Transport by iNteRcalatEd CelLS. Aims
 degradation. We hypothesi ze further  that  al dos te rone  inc reases Cl- abs o rpti on in the CCD, in part , byre d ucin g  t he as sociati o no f  th es etra ns p or terswit h NEDD4 -2. This p rop os al will diss e ct  the mecha nis m whereby in ter calate dcel l  NEDD 4-2  alte rs Cl- transp ort by in te r calate d  cells. A im s
 degradation._We hypothesize_further that aldosterone increases_Cl- absorption_in_the CCD,_in_part, by reducing_the association of_these transporters with NEDD4-2._This proposal will_dissect_the mechanism whereby intercalated cell NEDD4-2 alters Cl- transport by intercalated cells. Aims