premise: Norepinephrine induces neuromodulation by binding to receptor proteins.
hypothesis: Norepinephrine . Outside the brain , norepinephrine is used as a neurotransmitter by sympathetic ganglia located near the spinal cord or in the abdomen , and it is also released directly into the bloodstream by the adrenal glands . Regardless of how and where it is released , norepinephrine acts on target cells by binding to and activating noradrenergic receptors located on the cell surface . Norepinephrine (medication) . Norepinephrine works by binding and activating alpha adrenergic receptors .