premise: Elizabeth of York had no children.
hypothesis: Elizabeth of York . She was the mother of King Henry VIII . Therefore , she was the daughter , sister , niece , wife , mother and grandmother of successive Kings of England . Her two brothers disappeared , the `` Princes in the Tower '' , their fate unknown . Her marriage seems to have been successful , though her eldest son Arthur , Prince of Wales , died at age 15 in 1502 , and three other children died young . Her surviving children became a King of England and queens of France and Scotland ; it is through the Scottish Stuart dynasty that her many modern royal descendants trace their descent from her .