premise: Melancholia is a disease.
hypothesis: Melancholia ( from µέλαινα χολή , ) , also lugubriousness , from the Latin lugere , to mourn ; moroseness , from the Latin morosus , self-willed , fastidious habit ; wistfulness , from old English wist : intent , or saturnine , was a concept in ancient and pre-modern medicine . Melancholia is a 2011 science-fiction drama-psychological thriller film written and directed by Lars von Trier and starring Kirsten Dunst , Charlotte Gainsbourg , Alexander Skarsgård , Cameron Spurr , and Kiefer Sutherland .