premise: Rabies affects the brain.
hypothesis: Rabies is a viral disease that causes inflammation of the brain in humans and other mammals . The rabies virus travels to the brain by following the peripheral nerves . Rabies is a viral zoonotic neuroinvasive disease which causes inflammation in the brain and is usually fatal . Animals with rabies suffer deterioration of the brain and tend to behave bizarrely and often aggressively , increasing the chances that they will bite another animal or a person and transmit the disease .