premise: Francis I of France and Charles V, the Holy Roman Emperor, were rivals who engaged in wars against each other.
hypothesis: Francis I of France . He was also known as François au Grand Nez ( `` Francis of the Large Nose '' ) , the Grand Colas , and the Roi-Chevalier ( the `` Knight-King '' ) for his personal involvement in the wars against his great rival the Holy Roman Emperor and King of Spain Charles V. The succession of Charles V to the Burgundian Netherlands , the throne of Spain , and his subsequent election as Holy Roman Emperor , meant that France was geographically encircled by the Habsburg monarchy .