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"It’s not your imagination that it seems harder to lose weight once you’re overweight, as opposed to if you had just a little winter weight hanging around your middle. Your body wants to keep those extra pounds on, says science.One study conducted by researchers at the University of Cambridge in the U.K. found that the&nbsp;fatter we are, the more our body appears to produce a protein that inhibits our ability to burn fat, called sLR11. Though this initial research was based on a study of mice published in the journal Nature Communications, the researchers also examined sLR11 in humans and discovered that the greater the levels of the protein in the body, the higher the total fat mass. The protein binds to specific receptors on body’s fat cells, inhibiting their ability to activate thermogenesis, the production of heat in humans. Thermogenesis affects metabolism and helps you burn more calories."
<https://www.muscleandfitness.com/nutrition/healthy-eating/12-facts-you-should-know-about-fat/>