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"Overview\n\nHMG-CoA Reductase Inhibitors\n\nIndication\n\nHigh cholesterol\nPrevention of stroke\nPrevention of coronary vascular disease\n\nDecreases plaque formation in vessels\nBlood vessels are wider and blood can flow pretty easily through it\nIncrease good cholesterol\n\n\n\n\nMechanism of action\n\nPrevents the liver from making cholesterolnhibits by inhibiting HMG-CoA reductase enzyme\nPatho background-\n\nHMG-CoA reductase is an enzyme in the liver that produces cholesterol\n\nTypes of cholesterol\n\nVLDL-very low density lipoprotein\nLDL-low density lipoproteins\nTriglycerides\n\n\n\n\n\n\n\n\n\n\n\nNursing Points\nGeneral\n\nCommonly prescribed to patients who are at risk of CVA or MI due to having elevated cholersterol\nExamples\n\nSimvastatin\nAtorvostatin\nRosuvastatin\n\n\n\nAssessment\n\nAssess for side effects\n\nRhabdomyolysis- the breakdown of muscles.\nElevated Creatinine kinase\n\nAs muscles breakdown creatinine kinase is produced\nNormal value for male over 18 is approximately 52 - 336 U/L\n\n\nMuscle pain and tenderness\nHepatotoxicity\nAnorexia\nN/V\nJaundice\nPruritus\nPeripheral neuropathy\nTingling in hands and feet\n\n\n\nTherapeutic Management\n\nMonitor\n\nFor elevated creatinine kinase\nLiver function\nFor signs of myopathy\n\n\nAdministration\n\nTake at night after- because liver is more active then\nAvoid grapefruit and grapefruit juice due to increased risk for toxicity\n\n\n\nNursing Concepts\n\nPerfusion\n\nHMG-CoA Reductase Inhibitors help decrease cholesterol levels which will help decrease plaque formation and improve blood flow and perfusion.\n\n\nPharmacology\n\nHMG-CoA Reductase Inhibitor are commonly prescribed to patients who are at risk of CVA or MI due to having elevated cholersterol.\n\n\n\nPatient Education\n\nHMG-CoA Reductase Inhibitors should be taken in conjunction with dietary and lifestyle changes to help lower cholesteral levels.\nPatient should be instructed to notify their provider of any muscle tenderness as this could be a sign of myopathy."
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