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"Autoimmune disease is a condition in which the immune system attacks the body's own material just as aggressively as it would attack a foreign pathogen. Multiple sclerosis, MS for short, is just one such autoimmune disease, and is one of the most common neurological diseases in the 20 to 30 years age group. The disease can have very severe consequences for those afflicted, since the body's defenses attack the central nervous system. It has long been assumed that myelin is the most important target for the misdirected immune response. This white, fat-rich protective layer of specialized cells enshrouds the long extensions of neurons. However, the central nervous systems of MS patients also exhibit damage in the gray matter, where the nerve cell bodies are located. How the patient's disability develops depends greatly on the damage of the gray matter. An international group headed by medical scientist Professor Edgar Meinl of LMU Munich has now discovered a possible connection: The protein Contactin-2 is produced both in the myelin sheathing and by neurons in the gray matter - and is attacked by misdirected immune factors. &amp;quot;Our results suggest that these processes also play a role in MS patients,&amp;quot; says Meinl. &amp;quot;It could even be that proteins existing both in myelin and in the gray matter are in fact the critical points of attack.&amp;quot;"^^<http://www.w3.org/2001/XMLSchema#string>
<http://medicalxpress.com/news/2009-04-gray-multiple-sclerosis.html>