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"An antioxidant supplement known to help prevent blood clots during long air travel may also fight jet lag. Three times daily, starting two days before 10- to 14-hour flights, 32 people took 50 milligrams of Pycnogenol, an extract from maritime pine trees. Relative to untreated passengers, these people reported a more than 50 percent decrease in the severity and duration of fatigue, sleeping problems, irritability, and headaches. Though it's possible that some placebo effect was involved, Pycnogenol takers exhibited reduced brain and leg swelling caused by flying, which might partially explain the results, says Frank Schonlau, director of scientific communications at Horphag Research, the manufacturer of the supplement. It may cause mild stomach discomfort, he adds, so it's best taken after a meal."^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.allure.com/story/jet-lag-aid>