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" Question I&amp;#039;m taking Roaccutane for my acne.  I&amp;#039;ve been taking the tablets now for over five weeks and I&amp;#039;ve noticed in the last week or so that my urine has a very strong smell.  Could this be linked to my tablets? What do you advise?   Answer Roaccutane is an extremely effective drug in the treatment of acne and is used when milder treatments such as long-term antibiotics have not worked.  It is also an extremely powerful drug and as such can have very powerful side effects &amp;amp;#8211; this is why it is only prescribed by consultants rather than family doctors in the UK.  Although strong-smelling urine is not a side effect that is usually mentioned in connection with Roaccutane, it can cause excess production of protein in the urine, which could conceivably cause this symptom.  It should not be a reason for stopping this drug &amp;amp;#8211; which can take several months to clear severe acne &amp;amp;#8211; but it is a reason to collect a sample of your urine and get it tested by your doctor or practice nurse.  This will show up any infection or excess protein or blood, and if an infection is present this can be treated easily with antibiotics.  You should also let your doctor know of your symptoms. You may also simply be dehydrated &amp;amp;#8211; a very common cause of strong-smelling urine.  Your urine should be pale coloured or clear rather than dark yellow or orange and as a general rule the darker the urine the more dehydrated you are.  Try to drink at least eight glasses of water each day and cut down on tea and coffee since these have a diuretic effect (increase the amount of water lost from the kidneys). If you are prone to water infections anyway, you may also benefit from drinking cranberry juice every day since this is a natural antiseptic which helps keep the bladder and kidneys clear of infection.  Yours sincerely The NetDoctor Medical Team   Other Qs &amp;amp; As Antihistamine tablets Breathless and gaining weight Cataflam for a one-year-old Citalopram Citalopram hydrobromide Diclofenac and Kapake Glivec Glivec and AML Lamotrigiene Medicine for ear infection Medicines while breastfeeding Metronidazole and alcohol Steroid injections for pain Tylex Viral infection and antibiotics Warfarin Zyrtek and budesonide   Last updated 31.10.2010 "^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.netdoctor.co.uk/ask-the-expert/liver-kidney-and-urinary-system/a4045/urine-with-strong-smell/>