Safety and mammalian metabolism It is excreted as hippuric acid. Benzoic acid is metabolized by butyrate-CoA ligase into an intermediate product, benzoyl-CoA, Substrate/Product which is then metabolized by glycine N-acyltransferase into hippuric acid. Substrate/Product Humans metabolize toluene which is also excreted as hippuric acid.
SafEty aNd maMmaLiAN meTabOlIsM it is eXcreteD as hipPUric AcID. Benzoic acid iS MetaBOLiZed bY bUTyRate-coA LigaSE into an InterMedIAte prOduct, BenZOyL-coa, SubStRatE/produCt which is theN mETABolIzed bY GlycIne N-acylTrANSferasE inTO hIppuric acid. SubStRate/ProdUCt HumAns mETabolize ToLuEnE which Is aLso excREteD as hipPuriC AcID.