Geography Harleyville is located in northern Dorchester County at (33.2122, -80.4486). U.S. Route 178 passes through the center of town, leading northwest to Orangeburg and southeast to its terminus at U.S. Route 78. South Carolina Highway 453 leads north to Exit 177 on Interstate 26; I-26 leads northwest to Columbia and southeast to Charleston.
Geography Harleyville is located in northern Dorchester County at (332122 -804486) US Route 178 passes through the center of town leading northwest to Orangeburg and southeast to its terminus at US Route 78 South Carolina Highway 453 leads north to Exit 177 on Interstate 26; I-26 leads northwest to Columbia and southeast to Charleston