The disease progresses by forming granulation tissue at the edges of the synovial lining, pannus with extensive angiogenesis and enzymes causing tissue damage. The fibroblast-like synoviocytes have a prominent role in these pathogenic processes. The synovium thickens, cartilage and underlying bone disintegrate, and the joint deteriorates, with raised calprotectin levels serving as a biomarker of these events.
THe dIseASe pRogResses by formiNg graNulatiON tiSSuE At tHE eDGes of thE synOvial liNinG, PanNuS with exTeNsivE angiOgEnesIS and enzyMes causinG tISsue damage. the fIbroblAst-lIke SyNOViocyTes Have a pRoMinEnt rolE in THeSe pathOGenIc PrOcesses. ThE SynovIum THicKens, cartilaGe AnD underlYinG bONe dIsiNtegrATE, and The jOinT detErioratEs, with RAiseD calpRotectin LeVeLs serVing aS a biomaRkeR OF thEse eventS.