Other medicines Melatonin, there is tentative evidence for its use (at a dose of 10 mg) in reducing pain related to endometriosis. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis. Opioids: Morphine sulphate tablets and other opioid painkillers work by mimicking the action of naturally occurring pain-reducing chemicals called "endorphins". There are different long acting and short acting medications that can be used alone or in combination to provide appropriate pain control. Chinese herbal medicine was reported to have comparable benefits to gestrinone and danazol in patients who had had laparoscopic surgery, though the review notes that the two trials were small and of "poor methodological quality" and results should be "interpreted cautiously" as better quality research is needed. Serrapeptase, a digestive enzyme found in the intestines of silkworms. Serrapeptase is widely used in Japan and Europe as an anti-inflammatory treatment. More research is needed but serrapeptase may be used by endometriosis patients to reduce inflammation. Angiogenesis inhibitors lack clinical evidence of efficacy in endometriosis therapy. Under experimental in vitro and in vivo conditions, compounds that have been shown to exert inhibitory effects on endometriotic lesions include growth factor inhibitors, endogenous angiogenesis inhibitors, fumagillin analogues, statins, cyclo-oxygenase-2 inhibitors, phytochemical compounds, immunomodulators, dopamine agonists, peroxisome proliferator-activated receptor agonists, progestins, danazol and gonadotropin-releasing hormone agonists. However, many of these agents are associated with undesirable side effects and more research is necessary. An ideal therapy would diminish inflammation and underlying symptoms without being contraceptive. Pentoxifylline, an immunomodulating agent, has been theorized to improve pain as well as improve pregnancy rates in individuals with endometriosis. There is not enough evidence to support the effectiveness or safety of either of these uses. Current American Congress of Obstetricians and Gynecologists (ACOG) guidelines do not include immunomodulators, such as pentoxifylline, in standard treatment protocols. NSAIDs are anti-inflammatory medications commonly used for endometriosis patients despite unproven efficacy and unintended adverse effects. Neuromodulators like gabapentin did not prove to be superior to placebo in managing pain caused by endometriosis.
other medicines melatonin there is tentative evidence for its use (at a dose of 10 mg) in reducing pain related to endometriosis vitamin c and e antioxidant supplementation may significantly reduce pain symptoms in endometriosis opioids morphine sulphate tablets and other opioid painkillers work by mimicking the action of naturally occurring pain-reducing chemicals called "endorphins" there are different long acting and short acting medications that can be used alone or in combination to provide appropriate pain control chinese herbal medicine was reported to have comparable benefits to gestrinone and danazol in patients who had had laparoscopic surgery though the review notes that the two trials were small and of "poor methodological quality" and results should be "interpreted cautiously" as better quality research is needed serrapeptase a digestive enzyme found in the intestines of silkworms serrapeptase is widely used in japan and europe as an anti-inflammatory treatment more research is needed but serrapeptase may be used by endometriosis patients to reduce inflammation angiogenesis inhibitors lack clinical evidence of efficacy in endometriosis therapy under experimental in vitro and in vivo conditions compounds that have been shown to exert inhibitory effects on endometriotic lesions include growth factor inhibitors endogenous angiogenesis inhibitors fumagillin analogues statins cyclo-oxygenase-2 inhibitors phytochemical compounds immunomodulators dopamine agonists peroxisome proliferator-activated receptor agonists progestins danazol and gonadotropin-releasing hormone agonists however many of these agents are associated with undesirable side effects and more research is necessary an ideal therapy would diminish inflammation and underlying symptoms without being contraceptive pentoxifylline an immunomodulating agent has been theorized to improve pain as well as improve pregnancy rates in individuals with endometriosis there is not enough evidence to support the effectiveness or safety of either of these uses current american congress of obstetricians and gynecologists (acog) guidelines do not include immunomodulators such as pentoxifylline in standard treatment protocols nsaids are anti-inflammatory medications commonly used for endometriosis patients despite unproven efficacy and unintended adverse effects neuromodulators like gabapentin did not prove to be superior to placebo in managing pain caused by endometriosis