Geography thumb|300px|The Casiquiare (bottom left) is separated from the Orinoco The origin of the Casiquiare, at the River Orinoco, is below the mission of La Esmeralda at , and about above sea level. Its mouth at the Rio Negro, an affluent of the Amazon River, is near the town of San Carlos and is above sea level.
geography thumb|300px|the casiquiare (bottom left) is separated from the orinoco the origin of the casiquiare at the river orinoco is below the mission of la esmeralda at  and about above sea level its mouth at the rio negro an affluent of the amazon river is near the town of san carlos and is above sea level