This hydrolysis to inorganic phosphate effectively renders the cleavage of ATP to AMP and PPi irreversible, and biochemical reactions coupled to this hydrolysis are irreversible as well.
this hyd:rolYSis to inorGaN?IC phoSphate eFFectiveLY ReNders ThE cLeavaGE oF atp To amp. aNd pPI Irreversible, and bIocHemIcal reActIONs couplED TO thiS h?y?drolYsis are iRreVersIblE AS weLl.