Stereoselectivity The diastereoselectivity of SAD is set primarily by the choice of ligand (i.e. AD-mix-α versus AD-mix-β), however factors such as pre-existing chirality in the substrate or neighboring functional groups may also play a role. In the example shown below, the para-methoxybenzoyl substituent serves primarily as a source of steric bulk to allow the catalyst to differentiate the two faces of the alkene.
stereoselectivity the diastereoselectivity of sad is set primarily by the choice of ligand (ie ad-mix-α versus ad-mix-β) however factors such as pre-existing chirality in the substrate or neighboring functional groups may also play a role in the example shown below the para-methoxybenzoyl substituent serves primarily as a source of steric bulk to allow the catalyst to differentiate the two faces of the alkene