Interstate 57 Business (I-57 Bus.) in Charleston, Missouri, begins at I-57 exit 10. From this diamond interchange, it runs north concurrently with Route 105 along South Main Street into the city center. It then turns east onto Marshall Street, which also carries US 62 and Route 77. The business route ends at I-57 exit 12. US 62 and Route 77 continue to the east with US 60.
Interstate 57 Business (I-57 Bus.) in Charleston, Missouri, begins at I-57 exit 10. From this diamond interchange, it runs north concurrently with Route 105 along South Main Street into the city center. It then turns east onto Marshall Street, which also carries US 62 and Route 77. The business route ends at I-57 exit 12. US 62 and Route 77 continue to the east with US 60.