Biosynthesis and regulation Biosynthesis Almost all animal tissues synthesize cholesterol from acetyl-CoA. All animal cells (exceptions exist within the invertebrates) manufacture cholesterol, for both membrane structure and other uses, with relative production rates varying by cell type and organ function. About 80% of total daily cholesterol production occurs in the liver and the intestines; other sites of higher synthesis rates include the brain, the adrenal glands, and the reproductive organs.
BiOsynthEsIs and regulAtIOn BiOsYntheSIs aLMost all aniMal TIssues sYntheSiZe choleStErol fRoM aCetyl-coa. All AniMal cElls (ExcEpTionS exIsT witHIN the inverteBraTeS) MAnuFactUre choLesTeRoL, for botH mEmbrane sTruCTUre And other UsEs, wiTh rElatIve productIon rates varYING By cEll type and orgaN FuNction. aBOuT 80% Of tOtAl daiLy cHOlestEroL PRoDuction occurS in tHe liVeR aNd the inteSTiNEs; otHer siTes Of HIghEr SyNthesiS rates iNcludE The brain, thE adrENAl glandS, and tHe reproDuctivE oRgans.