According to the United States Census Bureau, the Murrells Inlet CDP has a total area of , of which are land and , or 2.21%, are water. It has a humid subtropical climate (Cfa) and average monthly temperatures range from 46.5 °F in January to 80.5 °F in July. The local hardiness zone is 8b.
According to the United States Census Bureau the Murrells Inlet CDP has a total area of  of which are land and  or 221% are water It has a humid subtropical climate (Cfa) and average monthly temperatures range from 465 °F in January to 805 °F in July The local hardiness zone is 8b