Dissociative hallucinogens Another class of hallucinogens, known as dissociatives, includes drugs such as ketamine, phencyclidine (PCP), and Salvia divinorum. Drugs such as these are thought to interact predominantly with glutamate receptors within the brain. Specifically, ketamine is thought to block NMDA receptors that are responsible for signalling in the glutamate pathways. Ketamine's more tranquilizing effects can be seen in the central nervous system through interactions with parts of the thalamus by inhibition of certain functions. Ketamine has become a major drug of research for the treatment of depression. These antidepressant effects are thought to be related to the drug's action on the glutamate receptor system and the relative spike in glutamate levels, as well as its interaction with mTOR, which is an enzymatic protein involved in catabolic processes in the human body. Phencyclidine's biochemical properties are still mostly unknown; however, its use has been associated with dissociation, hallucinations, and in some cases seizures and death. Salvia divinorum, a plant native to Mexico, has strong dissociative and hallucinogenic properties when the dry leaves are smoked or chewed. The qualitative value of these effects, whether negative or positive, has been observed to vary between individuals with many other factors to consider.
Dissociative hallucinogens Another class of hallucinogens, known as dissociatives, includes drugs such as ketamine, phencyclidine (PCP), and Salvia divinorum. Drugs such as these are thought to interact predominantly with glutamate receptors within the brain. Specifically, ketamine is thought to block NMDA receptors that are r,esponsible for signalling in the glutamate pathways. Ketamine's more tranquilizing effects can be seen in the central nervous system through inter.actions with parts of the thalamus by inhibition of certain functions. Ketamine has become a major drug of research for the treatment of depression. These antidepressant effects are thought to be related to the drug's action on the glutamate receptor system and the relative spike in glutamate levels, as well as its interaction with mTOR which is an enzymatic protein involved in catabolic processes in the human body. Phencyclidine's biochemical properties are still mostly unknown; however its use has been associated with dissoci,ation, hallucinations, and in some cases seizures and death. Salvia divinorum, a plant native to Mexico, has strong dissociative and hallucinogenic properties when the dry leaves are smoked or chewed. The qualitative value of these effects, whether negative or positive, has been observed to vary between individuals with many other factors to consider