Geography Chesnee is located near the northeast corner of Spartanburg County, and a small part of the city extends east into Cherokee County. U.S. Route 221 passes through the city as Alabama Avenue and Hampton Street, leading north to Rutherfordton, North Carolina, and south to Spartanburg. South Carolina Highway 11 (Cherokee Street) crosses US 221 in the center of town and leads west to Campobello and east past Cowpens National Battlefield to Gaffney.
Geography Chesnee is located near the northeast corner of Spartanburg County, and a small part of the city extends east into Cherokee County. U.S. Route 221 passes through the city as Alabama Avenue and Hampton Street, leading north to Rutherfordton, North Carolina, and south to Spartanburg South Carolina Highway 11 (Cherokee Street) crosses US 221 in the center of town and leads west to Campobello and east past. Cowpens National Battlefield to Gaffney.