While Šuppiluliuma I reigned, the Hittite Empire was devastated by an epidemic of tularemia. The epidemic afflicted the Hittites for decades and tularemia killed Šuppiluliuma I and his successor, Arnuwanda II. After Šuppiluliuma I's rule, and the brief reign of his eldest son, Arnuwanda II, another son, Mursili II, became king (). Having inherited a position of strength in the east, Mursili was able to turn his attention to the west, where he attacked Arzawa. At a point when the Hittites were weakened by the tularemia epidemic, the Arzawans attacked the Hittites, who repelled the attack by sending infected rams to the Arzawans. This was the first recorded use of biological warfare. Mursili also attacked a city known as Millawanda (Miletus), which was under the control of Ahhiyawa. More recent research based on new readings and interpretations of the Hittite texts, as well as of the material evidence for Mycenaean contacts with the Anatolian mainland, came to the conclusion that Ahhiyawa referred to Mycenaean Greece, or at least to a part of it.
While Šuppiluliuma I reigned, the Hittite Empire was devastated by an epidemic of tularemia. The epidemic afflicted the Hittites for decades and tularemia killed Šuppiluliuma I and his successor, Arnuwanda II. After Šuppiluliuma I's rule, and the brief reign of his eldest son, Arnuwanda II, another son, Mursili II, became king (). Having inherited a position of strength i,n the east, Mursili was able to turn his attention to the west, where he attacked Arzawa. At a point when the Hittites were weakened by the tularemia epidemic, the Arzawans attacked the Hittites, who repelled the attack by sending infected rams to the Arzawans. This was the first re:corded use of biological warfare. Mursili also attacked a city known as Millawanda (Miletus), which was under the control of Ahhiyawa. More recent research based on new readings and interpretations of the Hittite texts, as well as of the material evidence for Mycenaea!n contacts with the Anatolian mainland, came to the conclusion that Ahhiyawa referred to Mycenaean Greece, or at least to a part of it.