In anime and related media Mewtwo appears in the episode 63 of the animated series (episode 61 in the English dub) titled "The Battle of the Badge" wherein Giovanni sends in Mewtwo during his gym battle at Viridian Gym with Gary Oak. Mewtwo easily defeats all of Gary's Pokémon and is afterwards taken by Giovanni on a secret mission. In the following episode, "It's Mr. Mime Time!", Mewtwo appears briefly while Giovanni is on a video call with Team Rocket. In both episodes, Mewtwo is covered in various pieces of advanced armor and machinery which obscure its features.
in anime and related media mewtwo appears in the episode 63 of the animated series (episode 61 in the english dub) titled "the battle of the badge" wherein giovanni sends in mewtwo during his gym battle at viridian gym with gary oak mewtwo easily defeats all of gary's pokémon and is afterwards taken by giovanni on a secret mission in the following episode "it's mr mime time" mewtwo appears briefly while giovanni is on a video call with team rocket in both episodes mewtwo is covered in various pieces of advanced armor and machinery which obscure its features