Over more than six months of sertraline therapy for depression, people showed no significant weight increase. A 30-month-long treatment with sertraline for OCD also resulted in no significant weight gain. Although the difference did not reach statistical significance, the average weight gain was lower for fluoxetine (1%) but higher for citalopram, fluvoxamine and paroxetine (2.5%). Of the sertraline group, 4.5% gained a large amount of weight (defined as more than 7% gain). This result compares favorably with placebo, where, according to the literature, 3–6% of patients gained more than 7% of their initial weight. The large weight gain was observed only among female members of the sertraline group; the significance of this finding is unclear because of the small size of the group.
Over more than six months of sertraline therapy for depression, people showed no significant weight increase. A 30-month-long treatment with sertraline for OCD also resulted in no significant weight gain Although the difference did not reach statistical significance, the average weight gain was lower for fluoxetine (1%) but higher for citalopram, fluvoxamine and paroxetine (25%). Of the sertraline group, 4.5% gained a large amount of weight (defined as more than 7% gain). This result compares favorably with placebo, where, according to the literature, 3–6% of patients gained more than 7% of their initial weight The large weight gain was observed only among female members of the sertraline group; the significance of this finding is unclear because of the small size of the group.