However, in a study of emergency department patients with fractures, it was found that an equal amount of either drug provided about the same degree of pain relief, indicating that there is little practical difference between them when used for that purpose. Some references state that the analgesic action of hydrocodone begins in 20–30 minutes and lasts about 4–8 hours. The manufacturer's information says onset of action is about 10–30 minutes and duration is about 4–6 hours. Recommended dosing interval is 4–6 hours. Hydrocodone reaches peak serum levels after 1.3 hours.
howEVer, In a stUDY of emerGEncy DEparTMENT patIEnTs with fractUres, it waS foUnd That an equAl AMoUnt of eithER dRUg PRoVided ABoUt the SamE DEgRee OF paiN Relief, inDicating that thEre is littLe practIcAL difFErENCE betweeN them WHen used fOr thAt pUrPoSe. some REfEReNces staTe tHAt the anaLgesic actIon of hydroCoDone bEGinS In 20–30 MinUtes anD LAsts abOut 4–8 houRs. the mAnufaCturer's InfoRmation Says onSet OF ActIOn Is aBoUt 10–30 minUteS AnD DURatIoN is ABouT 4–6 Hours. rECOMmeNDed DoSing inTERvAL IS 4–6 hourS. HYDroCodoNe reaCheS peaK seRum LevElS aFter 1.3 Hours.