The town contains the northern termini of both Interstate 91 and U.S. Route 5, which parallel each other over the entire length of their routes. Interstate 91 has its final three interchanges in Derby. Several Vermont state routes, including Vermont Route 105, Vermont Route 111, and Vermont Route 191 also serve the town of Derby.
The town ContaiNs The nOrtHErn TermiNi of BOTh INterstate 91 anD U.S. rOuTe 5, whicH pAraLlEl EacH otHer oVer The entiRe LengtH Of ThEir roUtEs. inTerstate 91 Has iTS FINAL Three InteRchangEs in dErBy. several Vermont state rOutEs, incLuding vermonT rOutE 105, veRmont roUte 111, and vermont route 191 also SERVe tHe tOWn of Derby.