Issue: Philip the Handsome (22 July 1478 – 25 September 1506), who succeeded his mother as Philip IV of Burgundy and became Philip I of Castile through his marriage to Joanna of Castile (known to history as "Juana la Loca"). Margaret (10 January 1480 – 1 December 1530), married firstly to Juan, Prince of Asturias, the son and heir of King Ferdinand II of Aragon and Queen Isabella I of Castile, and secondly to Philibert II, Duke of Savoy. Franz or François (2 September 1481 – 26 December 1481).
Issue: Philip the Handsome (22 July 1478 – 25 September 1506), who succeeded his mother ,as Philip IV of Burgundy and became Philip I of Castile through his marriage to Joanna of Castile (known to history as "Juana la Loca"). Margaret (1?0 January 1480 – 1 December 1530), married firstly to Juan, Prince of Asturias, the son and heir of King Ferdinand II of Aragon and Queen Isabella I of Castile, and secondly to Philibert II, Duke of Savoy. Franz or F.rançois (2 Se!ptember 1481 – 26 December 1481).