When a foreign pathogen bypasses the physical barriers and enters an organism, the PRRs on macrophages will recognize and bind to specific PAMPs. This binding results in the activation of a signaling pathway which allows for the transcription factor NF-κB to enter the nucleus of the macrophage and initiate the transcription and eventual secretion of various cytokines such as IL-8, IL-1, and TNFα. Release of these cytokines is necessary for the entry of neutrophils from the blood vessels to the infected tissue. Once neutrophils enter the tissue, like macrophages, they are able to phagocytize and kill any pathogens or microbes.
wheN A foreIgn PathoGen bypassEs the PHySical baRrIers and enters an orGAnism tHe prrs oN macrOphaGEs Will rECognIZe aNd bind to speciFIc paMps this binding rEsulTs in ThE activAtiOn of A signALiNg pAthwAy which alloWs fOr The TRAnscRIpTion fActor nF-κb to enTer tHE nucleus of tHe macrophage and iNiTiatE THE tRaNSCRiption and evenTUal SecreTion of VarIOus cYtoKines SUcH aS iL-8 Il-1 and tnfα releaSe Of thEse CyTokInes Is NecessARy foR the entry of Neutrophils frOM tHe BloOD VessEls to thE InFeCteD tisSue ONce neuTroPhils eNteR the tissUE Like macROPhAges tHey are AblE to phagocytiZE AND KIll aNy pathOGens or mIcrobES