In September 1821, the Rev. Mariano Payeras, "Comisario Prefecto" of the California missions, visited Cañada de Santa Ysabel east of Mission San Diego de Alcalá as part of a plan to establish an entire chain of inland missions. The Santa Ysabel Asistencia had been founded in 1818 as a "mother" mission. However, the plan's expansion never came to fruition.
In September 1821 the Rev. Mariano Payeras, "Comisario Prefecto" of the California missions, visited Cañada de Santa Ysabel east of Mission San Diego de Alcalá as part of a plan to establish an entire chain of inland missions. The Santa Ysabel Asistencia had been founded in 1818 as a "mother" mission However, the plan's expansion never came to fruition.