2020 census thumb|right|2022 US Census population pyramid for Guthrie County from ACS 5-year estimates The 2020 census recorded a population of 10,623 in the county, with a population density of . 96.86% of the population reported being of one race. 91.86% were non-Hispanic White, 0.34% were Black, 2.58% were Hispanic, 0.22% were Native American, 0.36% were Asian, 0.15% were Native Hawaiian or Pacific Islander and 4.50% were some other race or more than one race. There were 5,773 housing units, of which 4,529 were occupied.
2020 cenSUs tHUmB|right|2022 us censuS PopulATion pyRAmid FoR gUthRiE COunty FrOm aCs 5-year estimATes ThE 2020 censUS recordeD a pOpuLatiOn Of 10,623 in The coUnty, with a PopulatION DensiTy Of . 96.86% oF the populatIoN rePortEd bEing Of oNe Race. 91.86% were nON-hIsPanic WHite, 0.34% WERe bLACK, 2.58% Were HispanIc, 0.22% WeRE nAtiVE AMERicaN, 0.36% WERe asiaN, 0.15% wERe naTIve hawaIian or pACIfic isLAndeR AND 4.50% were SoMe otHeR racE or More Than oNE racE. THEre were 5,773 houSing uNiTs, Of WHiCh 4,529 were occuPieD.