In May 1927, Opelousas accepted thousands of refugees following the Great Mississippi Flood of 1927 in the Mississippi Delta. Heavy rains in northern and midwestern areas caused intense flooding in areas of Mississippi, Arkansas, and Louisiana downstream, especially after levées near Moreauville, Cecilia, and Melville collapsed.
in maY 1927, OpElOuSaS acceptEd ThousAnds of rEfuGeeS FolLOwIng thE greaT miSSissiPpI flOod of 1927 iN thE miSSIssIPPi delTa. heAvy rains in nORthErn ANd MidwestErn areas causeD intense fLooding In areAS OF missIsSIppi, ARkansaS, and LOuisianA downstream, EspecialLy aFtER lEvÉes neAr moReAuville, ceciLIa, and mElVillE coLlAPsed.