Ciclosporin is highly metabolized in humans and animals after ingestion. The metabolites, which include cyclosporin B, C, D, E, H, and L, have less than 10% of ciclosporin's immunosuppressant activity and are associated with higher kidney toxicity.
ciclosporin is highly metabolized in humans and animals after ingestion the metabolites which include cyclosporin b c d e h and l have less than 10% of ciclosporin's immunosuppressant activity and are associated with higher kidney toxicity