26px U.S. Route 101 (US 101) is the most heavily used road transportation arterial for the city of Atascadero and serves as its north–south gateway. US 101 runs in a north–south direction and bisects the city (along with the Salinas River) into western and eastern portions. Traveling northward from the city, US 101 runs up to San Jose, San Francisco, and continues on along the coast up through Northern California, Oregon, and finally ends near Olympia in Washington state. Traveling southward from the city, US 101 heads down to San Luis Obispo, Santa Barbara, and on to Los Angeles, ending at the East Los Angeles Interchange. 24px State Route 41 (SR 41) is a major north–south highway in the State of California and runs in a northeast–southwest direction through the city. Traveling southbound, SR 41 leaves the city and gradually climbs up and over the Santa Lucia Coastal Range, where it then quickly descends and meets the Pacific Ocean, in the city of Morro Bay at its southern terminus where it meets SR 1 (the Pacific Coast Highway). Traveling northbound, SR 41 leaves the city and intersects with SR 229. After traveling through rolling countryside for about , it climbs up the Temblor Range and San Andreas Fault and overlaps with SR 46. About later, it crosses SR 33 and eventually Interstate 5 in the Central Valley before continuing toward Fresno.
26px U.S. Route 101 (US 101) is the most heavily used road transportation arterial for the city of Atascadero and serves as its north–south gateway. US 101 runs in a north–south direction and bisects the city (along with the Salinas River) into western and eastern portions. Traveling northward from the city, US 101 runs up to San Jose, San Francisco, and continues on along the coast up through Northern California, Oregon, and finally ends near Olympia in Washington state. Traveling southward from the city, US 101 heads down to San Luis Obispo, Santa Barbara, and on to Los Angeles, ending at the East Los Angeles Interchange. 24px State Route 41 (SR 41) is a major north–south highway in the State of California and runs in a northeast–southwest direction through the city. Traveling southbound, SR 41 leaves the city and gradually climbs up and over the Santa Lucia Coastal Range, where it then quickly descends and meets the Pacific Ocean, in the city of Morro Bay at its southern terminus where it meets SR 1 (the Pacific Coast Highway). Traveling northbound, SR 41 leaves the city and intersects with SR 229. After traveling through rolling countryside for about , it climbs up the Temblor Range and San Andreas Fault and overlaps with SR 46. About later, it crosses SR 33 and eventually Interstate 5 in the Central Valley before continuing toward Fresno.