In the blood stream, nascent chylomicron particles interact with HDL particles, resulting in HDL donation of apolipoprotein C-II and apolipoprotein E to the nascent chylomicron. The chylomicron at this stage is then considered mature. Via apolipoprotein C-II, mature chylomicrons activate lipoprotein lipase (LPL), an enzyme on endothelial cells lining the blood vessels. LPL catalyzes the hydrolysis of triglycerides that ultimately releases glycerol and fatty acids from the chylomicrons. Glycerol and fatty acids can then be absorbed in peripheral tissues, especially adipose and muscle, for energy and storage.
In tHe blOod stReam, NascEnt chylOmIcron partICles intEract wiTH hDL paRticles, Resulting in Hdl DOnAtiOn of apolipoprotein C-Ii aND APOlipopRoTein e TO the NAscent ChyloMiCrOn tHe ChylOMICROn at this sTaGe Is TheN considered mAtUre viA apOlipoprotein c-Ii, maTure chylomIcRons aCtIvate LipoproTeIn liPase (lpl), An enZYMe ON eNdoTheliAl cells linIng The blood vessElS. lpl catalYzes thE hydrolysis Of trigLyCERides That ULtimateLy reLeaSes glyCerol and FatTy ACIds from tHe ChYlOmicrOnS. glYCEROl and FATty acIds cAN tHeN be absorBed iN peRIpherAl tIssues, especiallY adipose And musCLe, fOr enERgy and Storage.