George Gamow established a group of scientists interested in the role of RNA as an intermediary between DNA as the genetic storage molecule in the nucleus of cells and the synthesis of proteins in the cytoplasm (the RNA Tie Club). It was clear to Crick that there had to be a code by which a short sequence of nucleotides would specify a particular amino acid in a newly synthesised protein. In 1956, Crick wrote an informal paper about the genetic coding problem for the small group of scientists in Gamow's RNA group."On Degenerate Templates and the Adaptor Hypothesis: A Note for the RNA Tie Club" by Francis Crick (1956). In this article, Crick reviewed the evidence supporting the idea that there was a common set of about 20 amino acids used to synthesise proteins. Crick proposed that there was a corresponding set of small "adaptor molecules" that would hydrogen bond to short sequences of a nucleic acid, and also link to one of the amino acids. He also explored the many theoretical possibilities by which short nucleic acid sequences might code for the 20 amino acids.
george gamow established a group of scientists interested in the role of rna as an intermediary between dna as the genetic storage molecule in the nucleus of cells and the synthesis of proteins in the cytoplasm (the rna tie club) it was clear to crick that there had to be a code by which a short sequence of nucleotides would specify a particular amino acid in a newly synthesised protein in 1956 crick wrote an informal paper about the genetic coding problem for the small group of scientists in gamow's rna group"on degenerate templates and the adaptor hypothesis a note for the rna tie club" by francis crick (1956) in this article crick reviewed the evidence supporting the idea that there was a common set of about 20 amino acids used to synthesise proteins crick proposed that there was a corresponding set of small "adaptor molecules" that would hydrogen bond to short sequences of a nucleic acid and also link to one of the amino acids he also explored the many theoretical possibilities by which short nucleic acid sequences might code for the 20 amino acids