NMDA receptor antagonists Ketamine, an NMDA receptor antagonist, is used primarily for its analgesic effects and in an off-label capacity for its anti-depressant effects. This drug, however, also alters arousal and is often used in parallel with other general anesthetics to help maintain a state of general anesthesia. Administration of ketamine alone leads to a dissociative state, in which a patient may experience auditory and visual hallucinations. Additionally, the perception of pain is dissociated from the perception of noxious stimuli. Ketamine appears to bind preferentially to the NMDA receptors on GABAergic interneurons, which may partially explain its effects.
NMDA receptor antagonists Ketamine, an NMDA receptor antagonist, is used primarily for ,its analgesic effects and in an off-label capacity ,for its anti-depressant effects. This drug however, also alters arousal and is often used in parallel with other general anesthetics to help maintain a state of general anesthesia. Administration of ketamine alone leads to a dissociative state in which a patient may experience auditory and visual hallucinations. Additionally, the perception of pain is dissociated from the perception of noxious stimuli. Ketamine appears to bind preferentially to the NMDA receptors on G,ABAergic interneurons which may partially explain its effects.