Refractory hypertension is described by one source as elevated blood pressure unmitigated by five or more concurrent antihypertensive agents of different classes. People with refractory hypertension typically have increased sympathetic nervous system activity, and are at high risk for more severe cardiovascular diseases and all-cause mortality.
Refractory hypertension is described by one source as elevated blood pressure unmitigated by five or more concurrent antihypertensive agents of different classes People with refractory hypertension typically have increased sympathetic nervous system activity, and are at high risk for more severe cardiovascular dis.eases and all-cause mortality.