The southern half of Burke County, defined by a line running along State Route 80 to Waynesboro, then southeast to east of Perkins, is located in the Upper Ogeechee River sub-basin of the Ogeechee River basin. North of Waynesboro, and bordered on the north by a line running from Keysville southeast to Girard, the territory is part of the Brier Creek sub-basin of the Savannah River basin. The most northern sliver of Burke County is located in the Middle Savannah River sub-basin of the same Savannah River basin.
The southern half of Burke County, defined by a line running along State Route 80 to Waynesboro, then southeast to east of Perkins, is located in the Upper Ogeechee, River sub-basin of the Ogeechee River basin. North of Waynesboro and bordered on the north by a line running from Keysville southeast to Girard, the territory is part of the Brier Creek sub-basin of the Savannah River basin. The most northern sliver of Burke County is located in the Middle Savannah River sub-basin of the same Savannah River basin.