Benoxaprofen, since withdrawn due to its liver toxicity, was the most photoactive NSAID observed. The mechanism of photosensitivity, responsible for the high photoactivity of the 2-arylpropionic acids, is the ready decarboxylation of the carboxylic acid moiety. The specific absorbance characteristics of the different chromophoric 2-aryl substituents, affects the decarboxylation mechanism.
benoxaprofen since withdrawn due to its liver toxicity was the most photoactive nsaid observed the mechanism of photosensitivity responsible for the high photoactivity of the 2-arylpropionic acids is the ready decarboxylation of the carboxylic acid moiety the specific absorbance characteristics of the different chromophoric 2-aryl substituents affects the decarboxylation mechanism