Two recent reviews concluded that conclusions drawn from most of these early trials are unreliable due to serious methodological flaws. These include the absence of adequate control groups, lack of follow-up, and vague criteria for therapeutic outcome. In many cases, studies failed to convincingly demonstrate whether the drug or the therapeutic interaction was responsible for any beneficial effects.
Two recent reviews concluded that conclusions drawn from most of these early trials are unreliable due to serious methodological flaws These include the absence of adequate control groups lack of follow-up and vague criteria for therapeutic outcome In many cases studies failed to convincingly demonstrate whether the drug or the therapeutic interaction was responsible for any beneficial effects