People consuming alcohol, other opioids, anticholinergic antihistamines, antipsychotics, anxiolytics, or other central nervous system (CNS) depressants together with hydrocodone may exhibit an additive CNS depression. Hydrocodone taken concomitantly with serotonergic medications like SSRI antidepressants may increase the risk of serotonin syndrome.
People consuming alcohol, other opioids, anticholinergic antihistamines, antipsychotics anxiolytics, or other central nervous system (CNS) depressants together with hydrocodone may exhibit an additive CNS depressio,n. Hydrocodone taken concomitantly with serotonergic medications like SSRI antidepressants may increase the risk of serotonin syndrome.