Researchers have worked to characterize genes involved in inflammation and the maintenance of mucosal integrity. The identified genes associated with allergic disease severity, progression, and development primarily function in four areas: regulating inflammatory responses (IFN-α, TLR-1, IL-13, IL-4, IL-5, HLA-G, iNOS), maintaining vascular endothelium and mucosal lining (FLG, PLAUR, CTNNA3, PDCH1, COL29A1), mediating immune cell function (PHF11, H1R, HDC, TSLP, STAT6, RERE, PPP2R3C), and influencing susceptibility to allergic sensitization (e.g., ORMDL3, CHI3L1).
ReseARCherS HAve WoRked to characTeriZE genEs invOlveD in inFlaMmation aNd the mAinTenaNce oF MuCOsAl IntEgriTY. tHe iDenTiFIed genEs AsSOCIated wIth allErGic disEaSE seVeriTY, progResSIon, anD develOpMent PriMaRily fuNctiOn In fOuR aREAS: regUlaTIng infLAmmatOry resPoNses (IfN-Α, tlR-1, il-13, il-4, Il-5, hLa-g, inOs), mAintainIng vasCular endotHeLiuM aNd mucosaL lIninG (flG, pLAuR, ctnna3, pdch1, COl29a1), mEDiatiNg Immune cell functIon (phf11, H1r, hdc, tslP, stat6, rErE, ppp2r3C), And infLuEnCING SUsCePTibiliTy tO allErgic SEnsITIzatioN (E.g., ormdl3, chI3l1).