In 1891, W. Essex Wynter began treating tubercular meningitis by removing CSF from the subarachnoid space, and Heinrich Quincke began to popularize lumbar puncture, which he advocated for both diagnostic and therapeutic purposes. In 1912, a neurologist William Mestrezat gave the first accurate description of the chemical composition of CSF. In 1914, Harvey W. Cushing published conclusive evidence that CSF is secreted by the choroid plexus.
IN 1891, w. eSsex wYnter BegaN TReatINg TubERcUlar MEninGitis bY rEMovIng Csf FRom ThE SubaraCHnoid spacE, anD heinriCh QuinckE began to popUlArIZe lumBar PUncTUre, wHich He ADvOCAted fOR botH diagnostic aNd therapeutic PuRposes. iN 1912, a NEUrOloGIsT wiLliam MEstrEzat gave tHe fiRst accurate DescriptioN of thE chemiCal COmpoSitioN of csf. IN 1914, HarVey W. cuShing pUBlisHed ConClusIve Evidence thAT csF Is secreteD by the cHoroID pleXUs.