U.S. Route 40, the National Road, crosses Henry Clay Township, leading southeast to Cumberland, Maryland, and northwest to Uniontown. Pennsylvania Route 281 crosses US 40 near the center of the township, leading northeast to Confluence and southwest through Markleysburg to the West Virginia border.
U.S. Route 40, the National Road, crosses Henry Clay Township, leading southeast to Cumberland, Maryland, and northwest to Uniontown. Pennsylvania Route 281 crosses US 40 near the center of the township leading northeast to Confluence and southwest through Markleysburg to the West Virginia border.