U.S. Route 30 is the main highway serving Downingtown. It follows the Coatesville-Downingtown Bypass on an east-west alignment across the northern tip of the borough. U.S. Route 30 Business follows the old alignment of US 30 through the heart of the borough along Lancaster Avenue. U.S. Route 322 also runs through the heart of the borough, following a northwest-to-southeast alignment via Manor Avenue, Lancaster Avenue and Brandywine Avenue and running concurrently with US 30 Business for a short stretch. Pennsylvania Route 113 starts at US 30 Business in the central part of the borough and heads north along Uwchlan Avenue. Finally, Pennsylvania Route 282 also starts at US 30 Business in the core of the borough and heads northward along Green Street, Pennsylvania Avenue and Wallace Avenue.
U.S. Route 30 is the main highway serving Downingtown. It follows the Coatesville-Downingtown Bypass on an east-west alignment across the northern tip of the borough. U.S. Route 30 Business follows the old alignment of US 30 through the heart of the borough along Lancaster Avenue. U.S. Route 322 also runs through the heart of the borough, following a northwest-to-southeast alignment via Manor Avenue Lancaster Avenue and Brandywine Avenue and running concurrently with US 30 Business for a short stretch. Pennsylvania Route 113 starts at US 30 Business in the central part of the borough and heads north along Uwchlan Avenue. Finally, Pennsylvania Route 282 also starts at US 30 Business in the core of the borough and heads northward along Green Street, Pennsylvania Avenue and Wall,ace Avenue.