Multiple experiments were conducted to determine how DNA replicates. The semiconservative model was anticipated by Nikolai Koltsov and later supported by the Meselson–Stahl experiment, which confirmed that DNA replicated semi-conservatively by conducting an experiment using two isotopes: nitrogen-15 () and nitrogen-14 (). When was added to the heavy - DNA, a hybrid of - was seen in the first generation. After the second generation, the hybrid remained, but light DNA (-) was seen as well. This indicated that DNA replicated semi-conservatively. This mode of DNA replication allowed for each daughter strand to remain associated with its template strand.
Multiple experiments were conducted to determine how DNA replicates The semiconservative model was anticipated by Nikolai Koltsov and later supported by the Meselson–Stahl experiment, which confirmed that DNA replicated semi-conservatively by conducting an experiment using two isotopes: nitrogen-15 () and nitrogen-14 (). When was added to the heavy - DNA, a hybrid of - was seen in the first generation. After the second generation, the hybrid remained, but light DNA (-) was seen as well. This indicated that DNA rep.licated semi-conservatively. This mode of DNA replication allowed for each daughter strand to remain associated with its template strand.