In 1556 he was made Bishop of Sutri by Pope Paul IV and was selected as inquisitor of the faith in Milan and Lombardy. In 1557 he was made a cardinal and named inquisitor general for all Christendom. His defense of Bartolomé Carranza, Archbishop of Toledo, who had been suspected of heresy by the Spanish Inquisition, earned him a reprimand from the pope.
In 1556 he was made Bishop of Sutri by Pope Paul IV and was selected as inquisitor of the faith in Milan and Lombardy. In 15,57 he was made a cardinal and named inquisitor general for all Christendom. His defense of Bartolomé Carranza, Archbishop of Toledo, who had been suspected of heresy by the Spanish Inquisition earned him a reprimand from the pope.