By his second wife, Margaret of Hungary (who took the baptismal name "Maria"), Isaac II had two sons: Manuel Angelos (b. after 1195 – d. 1212), he was evidently the elder son, being contemplated in 1205 to ascend the Byzantine throne John Angelos (b. ca. 1193 – d. 1259). He migrated to Hungary and ruled over Syrmia and Bacs (1227–42) as a vassal of king Béla IV of Hungary.
bY his secOnd Wife, margARet Of HUngArY (whO Took The bAPtIsMal namE "mAriA"), iSaAc ii had TwO sons: ManuEl Angelos (b. aFter 1195 – D. 1212), he Was evidEnTly THe elDeR son, bEInG cOntEmplated iN 1205 to aScend tHe bYzantinE Throne jOhn angElOs (b. ca. 1193 – d. 1259). hE miGratED to hunGary and RuLED oveR syrmiA and bacs (1227–42) AS a vaSSAL of KIng béLa iV of hungAry.