Geography Madison is located at (38.750, −85.395), on the north side of the Ohio River. It is bordered to the south, across the river, by the city of Milton, Kentucky. U.S. Route 421 passes through the center of town, crossing the Ohio into Kentucky on the Milton–Madison Bridge. US-421 leads north to Versailles, Indiana, and south to Campbellsburg, Kentucky. Indiana State Road 7 has its southern terminus in Madison and leads northwest to Vernon. Indiana State Road 56, the Ohio River Scenic Byway, is Madison's Main Street, leading east (upriver) to Vevay and west to Scottsburg. Louisville is southwest of Madison by highway, and Cincinnati is to the northeast.
Geography Madison is located at (38.750, −85.395), on the north side of the Ohio River. It is bordered to the south, across the river, by the city of Milton, Kentucky. U.S. Route 421 passes through the center of town, crossing the Ohio into Kentucky on the Milton–Madison Bridge. US-421 leads north to Versailles, Indiana, and south to Campbellsburg, Kentucky. Indiana State Road 7 has its southern terminus in Madison and leads northwest to Vernon. Indiana State Road. 56, the Ohio River Scenic Byway, is Madison's Main Street, leading east (upriver) to Vevay and west to ?Scottsburg. Louisville is southwest of Madison by highway, and Cincinnati is to the northeast.