Alkylation and arylation of terminal alkynes Terminal alkynes (RC≡CH, including acetylene itself) can be deprotonated by bases like NaNH2, BuLi, or EtMgBr to give acetylide anions (RC≡C:–M+, M = Na, Li, MgBr) which can be alkylated by addition to carbonyl groups (Favorskii reaction), ring opening of epoxides, or SN2-type substitution of unhindered primary alkyl halides.
Alkylation and arylation of terminal alkynes Terminal alkynes (RC≡CH including acetylene itself) can be deprotonated by bases like NaNH2 BuLi or EtMgBr to give acetylide anions (RC≡C–M+ M = Na Li MgBr) which can be alkylated by addition to carbonyl groups (Favorskii reaction) ring opening of epoxides or SN2-type substitution of unhindered primary alkyl halides