A number of phenothiazines other than methylene blue have been shown to have antimicrobial effects. In particular, thioridazine has been shown to make extensively drug-resistant tuberculosis (XDR-TB) drug-susceptible again and make methicillin-resistant Staphylococcus aureus (MRSA) susceptible to beta-lactam antibiotics. The major reason why thioridazine has not been utilized as an antimicrobial agent is due to adverse effects on the central nervous system and cardiovascular system (particularly QT interval prolongation).
A number of phenothiazines other than methylene b,lue have been shown to have antimicrobial effects. In particular, thioridazine has been shown to make extensively drug-resistant tuberculosis (XDR-TB) drug-susceptible again and make methicillin-resistant Staphylococ,cus aureus (MRSA) susceptible to beta-lactam antibiotics. The major reason why thioridazine has not been utilized as an antimicrobial agent is due to adverse effects on: the central nervous system and cardiovascular system (particularly QT interval prolongation).