PCP, like ketamine, also acts as a potent dopamine D2High receptor partial agonist in rat brain homogenate and has affinity for the human cloned D2High receptor. This activity may be associated with some of the other more psychotic features of PCP intoxication, which is evidenced by the successful use of D2 receptor antagonists (such as haloperidol) in the treatment of PCP psychosis.
PCP like ketamine also acts as a potent dopamine D2High receptor partial agonist in rat brain homogenate and has affinity for the human cloned D2High receptor This activity may be associated with some of the other more psychotic features of PCP intoxication which is evidenced by the successful use of D2 receptor antagonists (such as haloperidol) in the treatment of PCP psychosis