Carbon monoxide has a second toxic effect, namely removing the allosteric shift of the oxygen dissociation curve and shifting the foot of the curve to the left. In so doing, the hemoglobin is less likely to release its oxygen at the peripheral tissues. Certain abnormal hemoglobin variants also have higher than normal affinity for oxygen, and so are also poor at delivering oxygen to the periphery.
Carbon monoxide has a second toxic eff.ect, namely removing the allosteric shift of the oxygen dissociation curve and shifting the foot of the curve to the left In so doing, the hemoglobin is less likely to release its oxygen at the peripheral tissues. Certain abnormal hemoglobin variants also have higher than normal affinity for oxygen, and so are also poor at delivering oxygen to the periphery.