Pathophysiology thumb|Continuous pressure on the spine can destroy the intervertebral disc and cause the sciatic nerve to actively produce pain. The mechanism of continuous activation and transmission of pain messages, leads the body to an activity to relieve pain (a mechanism to prevent damage in the body), this action causes the release of prostaglandin and increase the sensitivity of that part to stimulation; Prostaglandin secretion causes unbearable and chronic pain. Under persistent activation, the transmission of pain signals to the dorsal horn may produce a pain wind-up phenomenon. This triggers changes that lower the threshold for pain signals to be transmitted. In addition, it may cause non-nociceptive nerve fibers to respond to, generate, and transmit pain signals. Researchers believe that the nerve fibers that cause this type of pain are group C nerve fibers; these fibers are not myelinated (have low transmission speed) and cause long-term pain.
pathophysiology thumb|continuous pressure on the spine can destroy the intervertebral disc and cause the sciatic nerve to actively produce pain the mechanism of continuous activation and transmission of pain messages leads the body to an activity to relieve pain (a mechanism to prevent damage in the body) this action causes the release of prostaglandin and increase the sensitivity of that part to stimulation; prostaglandin secretion causes unbearable and chronic pain under persistent activation the transmission of pain signals to the dorsal horn may produce a pain wind-up phenomenon this triggers changes that lower the threshold for pain signals to be transmitted in addition it may cause non-nociceptive nerve fibers to respond to generate and transmit pain signals researchers believe that the nerve fibers that cause this type of pain are group c nerve fibers; these fibers are not myelinated (have low transmission speed) and cause long-term pain