Mesembrenone, an alkaloid from the herb Sceletium tortuosum Rolipram, used as investigative tool in pharmacological research Ibudilast, a neuroprotective and bronchodilator drug used mainly in the treatment of asthma and stroke. It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a more potent inhibitor than rolipram. Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Drotaverine, used to alleviate renal colic pain, also to hasten cervical dilatation in labor Roflumilast, indicated for people with severe COPD to prevent symptoms such as coughing and excess mucus from worsening Apremilast, used to treat psoriasis and psoriatic arthritis. Crisaborole, used to treat atopic dermatitis. Glaucine, an aporphine alkaloid, low-potency PDE4 inhibitor, calcium channel blocker, dopamine antagonist and 5-HT2A positive allosteric modulator, used as antitussive in Eastern Europe and Iceland.
MesEmBrenone, an AlkALOid from the Herb sceletium toRtUosUm rOlipram, used aS iNvestIgAtive Tool IN phArmACologiCal rESeaRch iBuDIlAsT, a NeuroproTeCTivE anD bronchoDILatOr drug uSEd mAiNly in The treatMent of aSThma anD stRoke. IT InhIbits pde4 to The greATest extent, BuT also sHOWs significaNt iNHIbiTioN Of other pde suBtyPEs, aND sO aCts as a sElective Pde4 inHIbitor Or a non-SeleCTiVE PhOSphOdIESTeRaSE inhibitOr, DepenDINg oN thE dOsE. piclamilast, a more pOtEnt inHIBitor THan rOlipRAm. luteolin, supplemEnT extRacTed frOM peanuts thAt alSo posSEsses IGF-1 pRoperTieS. drOtAverine, used To allEvIate reNaL colIC pAIN, ALSo To HaSTen CErVical DilaTaTiOn IN labor RoflUMilast, indIcated for PEople WitH severe copd to preVENt Symptoms sUcH As cougHiNg aND excess mucuS from woRSeNing apremilast, useD TO TreaT psorIASis AnD psoRiatIc artHRitis. CrisABOrolE, used To treAT aTOpic Dermatitis. gLaUcINE, AN aporPHinE aLKaLoid, low-pOtEncy Pde4 INHiBiTOr, calcium CHannel blockER, dopamine antagOnISt AnD 5-ht2a posiTiVe aLlosTErIC modulator, UsEd aS aNtitUSSIvE in EastERN Europe aNd icElanD.