Thymidine imbalance induces mutation and recombination During growth of bacteriophage T4, an excess of thymidine availability increases mutation. A deficiency of thymidine during growth also increases mutation. A thymidylate auxotroph of the diploid yeast Saccharomyces cerevisiae was grown under conditions in which thymidyate levels varied from excess to depletion. High levels of thymidylate were observed to be mutagenic and recombinogenic, whereas starvation for thymidylate was recombinogenic but only slightly mutagenic.
thymidine imbalance induces mutation and recombination during growth of bacteriophage t4 an excess of thymidine availability increases mutation a deficiency of thymidine during growth also increases mutation a thymidylate auxotroph of the diploid yeast saccharomyces cerevisiae was grown under conditions in which thymidyate levels varied from excess to depletion high levels of thymidylate were observed to be mutagenic and recombinogenic whereas starvation for thymidylate was recombinogenic but only slightly mutagenic