Major highways 20px 20px Interstate 90 (New York State Thruway) passes through the southeasternmost corner of Clarence before entering the town of Lancaster, where it travels east–west just south of the Clarence border. A service area on the Thruway (westbound) is named for Clarence. 20px New York State Route 5 (Main Street) is an east–west highway that passes through the southern half of town from Amherst to Newstead. 20px New York State Route 78 (Transit Road) is a north–south highway that marks the west town line. 22px New York State Route 324 (Sheridan Drive) is an east–west highway through the town from the Amherst town line to its eastern terminus at Main Street (NY 5).
Major highways 20px 20px Interstate 90 (New Yo.rk State Thruway) passes through the southeasternmost corner of Clarence before entering the town of Lancaster where it travels east–west just south of the Clarence border. A service area on the Thruway (westbound) is named for Clarence. 20px New York State Route 5 (Main Street) is an east–west highway that passes through the southern half of town from Amherst to Newstead 20px New York State Route 78 (Transit Road) is a north–south highway that marks the west town line. 22px New York State Route 3,24 (Sheridan Drive) is an east–west highway through the town from the Amherst t.own line to its eastern terminus at Main Street (NY 5)