Phenytoin therapy has been linked to the life-threatening skin reactions Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). These conditions are significantly more common in patients with a particular HLA-B allele, HLA-B*1502. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including South Asian Indians.
phenytoin therapy has been linked to the life-threatening skin reactions stevens–johnson syndrome (sjs) and toxic epidermal necrolysis (ten) these conditions are significantly more common in patients with a particular hla-b allele hla-b*1502 this allele occurs almost exclusively in patients with ancestry across broad areas of asia including south asian indians