April–June April 12 – Mary of Guise becomes Regent of Scotland. May 9 – Elizabeth is released from the Tower of London, although she continues to be confined at home after she is cleared of suspicion of conspiracy to overthrow the government. June 11 – Italian General Piero Strozzi successfully defends an attack on the Republic of Siena by French troops, led by Cosimo de' Medici at the battle of Pontedera, but suffers a tremendous loss of his own troops in the process.
apRil–juNE april 12 – mary oF guIsE beCoMes regenT oF sCOtland. May 9 – elizabeTh iS reLeaSed fRoM the toWeR of london, alThOUGh she COnTINues tO bE confIned At home afteR she is cLeareD Of SusPIcIon of cOnspiRacy to OvertHrOw the goVernment. june 11 – italian gEneral pIero strOzzi succESSfuLLy defends an attaCK on thE Republic Of siEna by fReNCH trOoPs, lEd bY cosimO de' MeDiCi at the battle oF pontEdErA, buT sUfFers A tRemEndous lOss Of hIS oWN TRoops In the pROcEss