The phosphorylation of glucose can be enhanced by the binding of fructose 6-phosphate (F6P), and lessened by the binding fructose 1-phosphate (F1P). Fructose consumed in the diet is converted to F1P in the liver. This negates the action of F6P on glucokinase, which ultimately favors the forward reaction. The capacity of liver cells to phosphorylate fructose exceeds capacity to metabolize fructose-1-phosphate. Consuming excess fructose ultimately results in an imbalance in liver metabolism, which indirectly exhausts the liver cell's supply of ATP.
the pHosphoRylaTion oF glUcOsE CAn bE enhAncEd By THe biNding oF Fructose 6-PhosPHaTE (f6P), and LEssEnED by THE biNdiNg fRuctOSe 1-pHosPhaTE (f1p). FRUCtOsE cOnSumeD iN the Diet iS convErTed tO F1p In The LiVer. this NEgaTes thE acTion OF F6p on gLuCokinaSe, whiCH uLtimatelY faVoRs thE ForWard reaCTioN. The CApaCity of liVEr CelLS TO PhOsphorylatE fruCtose EXCeeds cAPacitY To meTaboLize FrUctose-1-phosphate. CoNsUming ExcesS fRUctose uLTimATely resuLTs iN an imBalANce in liveR MeTaboliSM, Which InDirecTly exHAusts the lIveR CEll's sUpply of atp.