The surface area to volume ratio (SA:V) of a cell imposes upper limits on size, as the volume increases much faster than does the surface area, thus limiting the rate at which substances diffuse from the interior across the cell membrane to interstitial spaces or to other cells. Indeed, representing a cell as an idealized sphere of radius , the volume and surface area are, respectively, and . The resulting surface area to volume ratio is therefore . Thus, if a cell has a radius of 1 μm, the SA:V ratio is 3; whereas if the radius of the cell is instead 10 μm, then the SA:V ratio becomes 0.3. With a cell radius of 100, SA:V ratio is 0.03. Thus, the surface area falls off steeply with increasing volume.
The surface area to volume ratio (SA:V) of a cell imposes upper limits on size, as the volume increases much faster than does the surface area, thus limiting the rate at which substances diffuse from the interior across the cell membrane to interstitial spaces or to other cells. Indeed, representing a cell as an idealized sphere of radius , the volume and surface area are, respectively, and . The resulting surface area to volume ratio is therefore . Thus, if a cell has a radius of 1 μm, the SA:V ratio is 3; whereas if the radius of the cell is instead 10 μm, then the SA:V ratio becomes 0.3. With a cell radius of 100, SA:V ratio is 0.03. Thus, the surface area falls off steeply with increasing volume.