thumb|left|Francisco Javier Girón y Ezpeleta Duque de Ahumada Several lines of descendants exist in Mexico and Spain through Moctezuma II's son and daughters, notably Tlacahuepan Ihualicahuaca, or Pedro Moctezuma, and Tecuichpoch Ixcaxochitzin, or Isabel Moctezuma. Following the conquest, Moctezuma's daughter, Techichpotzin (or Tecuichpoch), became known as Isabel Moctezuma and was given a large estate by Cortés, who also fathered a child by her, Leonor Cortés Moctezuma, who in turn was the mother of Isabel de Tolosa Cortés de Moctezuma. Isabel married consecutively to Cuauhtémoc (the last Mexican sovereign), to a conquistador in Cortés' original group, Alonso Grado (died c. 1527), a poblador (a Spaniard who had arrived after the fall of Tenochtitlán), to Pedro Andrade Gallego (died c. 1531), and to conquistador Juan Cano de Saavedra, who survived her. She had children by the latter two, from whom descend the illustrious families of Andrade-Montezuma and Cano-Montezuma. A nephew of Moctezuma II was Diego de Alvarado Huanitzin.
thumb|left|Francisco Javier Girón y Ezpeleta Duque de Ahumada Several lines of descendants exist in Mexico and Spain through Moctezuma II's son and daughters notably Tlacahuepan Ihualicahuaca or Pedro Moctezuma and Tecuichpoch Ixcaxochitzin or Isabel Moctezuma Following the conquest Moctezuma's daughter Techichpotzin (or Tecuichpoch) became known as Isabel Moctezuma and was given a large estate by Cortés who also fathered a child by her Leonor Cortés Moctezuma who in turn was the mother of Isabel de Tolosa Cortés de Moctezuma Isabel married consecutively to Cuauhtémoc (the last Mexican sovereign) to a conquistador in Cortés' original group Alonso Grado (died c 1527) a poblador (a Spaniard who had arrived after the fall of Tenochtitlán) to Pedro Andrade Gallego (died c 1531) and to conquistador Juan Cano de Saavedra who survived her She had children by the latter two from whom descend the illustrious families of Andrade-Montezuma and Cano-Montezuma A nephew of Moctezuma II was Diego de Alvarado Huanitzin