Geography Interstate 85 crosses the southeastern edge of the town, with access from Exits 202, 204, and 206; I-85 leads southwest to Durham and northeast to Petersburg, Virginia. U.S. Route 15 passes through the center of Oxford as Lewis Street, Hillsboro Street, and College Street, leading southwest to Creedmoor and north to Clarksville, Virginia. U.S. Route 158 bypasses Oxford on the northern side, leading east to Henderson and west to Roxboro.
Geography Interstate 85 crosses the southeastern edge of the town, with access from Exits 202, 204 and 206; I-85 leads southwest to Durham and northeast to Petersburg, Virginia. U.S. Route 15 passes through the center of Oxford as Lewis Street Hillsboro Street, and College Street, leading southwest to Creedmoor and north to Clarksville, Virginia. U.S. Route 158 bypasses Oxford on the northern side, leading east to Henderson and west to Roxboro.