During the 1970s and 1980s the population stagnated, and by the 1990s Muleshoe's population had begun to decrease. The population went from 5,048 in 1988 to 4,530 in 2000. The once lively and vibrant Main Street is now quiet, with many abandoned buildings. Many of the businesses that once called Main Street home are now on American Boulevard (US Highway 84/70).
During the 1970s and 1980s the population stagnated, and by the 1990s Muleshoe's population had begun to decrease. The population went from 5,048 in 1988 to 4,530 in 2000. The once lively and vibrant Main Street is now quiet, with many abandoned buildings. Many of the businesses that once called Main Street home are now on American Boulevard (US Highway 84/70).