thumb|507x507px|Hemodynamic changes observed on gyrencephalic brain cortex after an arterial vessel occlusion in IOS. The video has a speed of 50x to better appreciate the spreading depolarization over the brain cortex. Pictures are dynamically subtracted to a reference picture 40 s before. First we see the initial area of change at the exact moment where the middle cerebral artery group (left) is occluded. The area is highlighted with a white line. Later we appreciate the signal produced by Spreading Depolarizations. We see markedly the front of waves. https://doi.org/10.1007/s00701-019-04132-8 Neurodegenerative diseases such as Alzheimer's disease, show as a marker, an atrophy of the grey matter of the cerebral cortex.
thumb|507x507px|Hemodynamic changes observed on gyrencephalic brain cortex after an arterial vessel occlusion in IOS. The video has a speed of 50x to better appreciate the spreading depolarization over the brain cortex. Pictures are dynamically subtracted to a reference picture 40 s before. First we see the initial area of change at the exact. moment where the middle cerebral artery group (left) is occluded. The area is highlighted with a white line Later we appreciate the signal produced by Spreading Depolarizations. We see markedly the front of waves. https://doi.org/10.1007/s00701-019-04132-8 Neurodegenerative diseases such a.s Alzheimer's disease, show as a marker, an atrophy of the grey matter of the cerebral cortex