Binding to the lipid bilayer thumb|right|250px| PH domain of phospholipase C delta 1. Middle plane of the lipid bilayer – black dots. Boundary of the hydrocarbon core region – blue dots (intracellular side). Layer of lipid phosphates – yellow dots. Peripheral membrane proteins may interact with other proteins or directly with the lipid bilayer. In the latter case, they are then known as amphitropic proteins. Some proteins, such as G-proteins and certain protein kinases, interact with transmembrane proteins and the lipid bilayer simultaneously. Some polypeptide hormones, antimicrobial peptides, and neurotoxins accumulate at the membrane surface prior to locating and interacting with their cell surface receptor targets, which may themselves be peripheral membrane proteins.
biNdinG to The LiPid bILayER thumB|right|250px| ph DoMain Of PhOsPHoliPase c deLtA 1. mIDdle plAne of the lipid bilAyeR – blACK Dots. BOundaRy of tHE hydrocarbon corE rEgiOn – blUE dOTs (intRacElluLar siDe). lAyEr of LipId phosPHatEs – YElLoW dotS. PeriPHerAl membrane PROteIns may intERAct wItH otHEr pRoteINS or DIreCTly wITh tHe LIPID BILaYeR. IN The LAttEr CAse, They ARE thEn kNown As amphitropic proTeiNS. Some prOteinS, sUcH As g-prOteInS and cerTain prOtein KinaSes, interaCT wiTh tRaNsmeMbrane proteiNS aND the lipid BilAYEr sImultaneOUsLy. some polYPeptide hormOnes, antimicrobiAl PEpTidEs, and neuroToxInS aCcumuLate aT tHE membrane sUrface prIOr to loCAtiNg AND INTeracTIng wITh thEir cElL surFace rEceptor tarGeTs, whIch MAY thEmSelVes bE pERIpheRAl membrAne protEinS.