In 2018, Kane was cast in Jacques Audiard's Western film The Sisters Brothers. In 2019, she appeared in Jim Jarmusch's horror comedy The Dead Don't Die, marking another collaboration with Bill Murray. That same year, she was featured in the recurring role of Bianca Nova in season one of the HBO series Los Espookys, where she reunited with her Unbreakable Kimmy Schmidt castmate Fred Armisen.
In 2018, Kane was cast in Jacques Audiard's Western film The Sisters Brother.s. In 2019, she appeared in Jim Jarmusch's horror comedy The Dead Don't Die, marking another collaboration with Bill Murray. That same year, she was featured in the recurring role of Bianca Nova in season one of the HBO series Los Espookys, where she reunited with her Unbreakable Kimmy Schmidt castmate Fred Armisen