In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm (83 mg per liter), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2,100 mg daily for a adult). Until about 2010, quinine was often recommended as a relief for leg cramps, although medical research suggested some care was needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps.
in the united states the us food and drug administration (fda) limits the quinine content in tonic water to 83 ppm (83 mg per liter) while the daily therapeutic dose of quinine is in the range of 500–1000 mg and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a adult) until about 2010 quinine was often recommended as a relief for leg cramps although medical research suggested some care was needed in monitoring doses because of quinine's risks the fda cautions consumers against using "off-label" quinine drugs to treat leg cramps