Enzymes function by lowering the activation energy of the transition state of a chemical reaction, thereby enabling the formation of an otherwise less-favorable molecular intermediate between the reactant(s) and the product(s). If an antibody is developed to bind to a molecule that is structurally and electronically similar to the transition state of a given chemical reaction, the developed antibody will bind to, and stabilize, the transition state, just like a natural enzyme, lowering the activation energy of the reaction, and thus catalyzing the reaction. By raising an antibody to bind to a stable transition-state analog, a new and unique type of enzyme is produced.
Enzymes function by lowering the activation energy of the transition state of a chemical reaction thereby enabling the formation of an otherwise less-favorable molecular intermediate between the reactant(s) and the product(s) If an antibody is developed to bind to a molecule that is structurally and electronically similar to the transition state of a given chemical reaction the developed antibody will bind to and stabilize the transition state just like a natural enzyme lowering the activation energy of the reaction and thus catalyzing the reaction By raising an antibody to bind to a stable transition-state analog a new and unique type of enzyme is produced