Before VNTRs and STRs, people like Jeffreys used a process called restriction fragment length polymorphism (RFLP). This process regularly used large portions of DNA to analyze the differences between two DNA samples. RFLP was among the first technologies used in DNA profiling and analysis. However, as technology has evolved, new technologies, like STR, emerged and took the place of older technology like RFLP.
befoRe VNtRS aND Strs, pEopLE liKe jeffrEys useD a process cALLed reStrictioN fRagmeNT lEngTH poLymoRphism (rFLp). thIs PrOcesS regULArly usEd largE pOrTIons Of DNa to analyZe the DiFFereNCes Between two dna SaMplEs. rflp was amOng THe firSt tEChnOLOgIes uSed in dna profiLIng anD aNalYsis. hOwEver, aS tEcHNology hAs eVolveD, nEw teCHnOlogieS, LiKe stR, emerged aNd tOok THe plaCe of olDer tecHNOLogY likE rflp.