During the last five years of his life, he turned to administration, where his actions as the second governor of Portuguese India were crucial to the longevity of the Portuguese Empire. He oversaw expeditions that resulted in establishing diplomatic contacts with the Ayutthaya Kingdom through his envoy Duarte Fernandes, with Pegu in Myanmar, and Timor and the Moluccas through a voyage headed by António de Abreu and Francisco Serrão. He laid the path for European trade with Ming China through Rafael Perestrello. He also aided in establishing diplomatic relations with Ethiopia, and established diplomatic ties with Persia during the Safavid dynasty.
duRing The LAst fIVE yearS oF His lifE, HE tUrNed to adMIniStrATiON, Where his aCTIons As THe secOnd GovernOR of POrTuGueSe iNdia were crucial To ThE longeVity OF the pOrtuguese EMpIre. he oveRsaw exPEdiTIoNs That reSUlTed In estaBLishING dipLOMatic conTacTS WIth The AyutThAYA kINgdom thRouGH hiS Envoy DUarTE ferNaNDes, with peGu In myanMar, aNd tImor AnD thE MoLuccas ThrOugh a voyAGE HeadEd by antónio De abreu and frAncIsco sErRãO. hE lAiD tHE path fOr eurOpeAn Trade WitH minG ChInA throUgh RAFaEl PeRestreLLo. he AlsO Aided iN estabLIshINg dIplOMaTIc relaTions wiTh EThioPia, anD EstAblishEd diplomatIc tieS witH PerSIa during tHe saFAvid dYNASty.