Interstate 87 (the "Adirondack Northway") and U.S. Route 9 pass through the eastern part of the town. New York State Route 146 is an east–west highway through most of the center of Clifton Park until it takes a 90 degree turn southward, passing east of the hamlet of Rexford and then crossing the Rexford bridge into the Town of Niskayuna in Schenectady County.
Interstate 87 (the "Adirondack Northway") and US. Route 9 pass through the eastern part of the town. New York State Route 146 is an east–west highway through most of the center of Clifton Park until it takes a 90 degree turn southward, passing east of the hamlet of Rexford and then crossing the Rexford bridge into the Town of Niskayuna in Schenectady County.