Refractory celiac disease can be divided in type I and II. A recent studied compared patients with type I and II. Refractory celiac disease type I more frequently exhibits diarrhea, anemia, hypoalbuminemia, parenteral nutrition need, ulcerative jejuno-ileitis, and extended small intestinal atrophy. Among patients with refractory celiac disease type II is more common to develope lymphoma. Among these patients, atrophy extension was the only parameter correlated with hypoalbuminemia and mortality. Elli L, Soru P, Roncoroni L, Rossi FG, Ferla V, Baldini L, Nandi N, Scaramella L, Scricciolo A, Rimondi A, Fusco N, Croci GA, Gianelli U, Cro L, Barbieri M, Lombardo V, Costantino A, Vaira V, Ferrero S, Tontini GE, Barigelletti G, Fabiano S, Doneda L, Vecchi M. Clinical features of type 1 and 2 refractory celiac disease: Results from a large cohort over a decade. Dig Liver Dis. 2023 Feb;55(2):235-242. doi: 10.1016/j.dld.2022.08.022. Epub 2022 Sep 10. PMID: 36096991.
Refractory celiac disease can be divided in type I and II. A recen,t studied compared patients with type I and II. Refractory celiac disease type I more frequently exhibits diarrhea anemia, hypoalbuminemia, parenteral nutrition need, ulcerative jejuno-ileitis, and extended small intestinal atrophy. Among patients with refractory celiac disease type II is more common to develope lymphoma. Among these patients, atrophy extension was the only parameter correlated with hypoalbuminemia and mortality. Elli L, Soru P, Roncoroni L, Rossi FG, Ferla V, Baldini L, Nandi N, Scaramella L, Scricciolo A, Rimondi A, Fusco N, Croci GA, Gianelli U, Cro L, Barbieri M, Lombardo V, Costantino A, Vaira V, Ferrero S, Tontini GE, Barigelletti G, Fabiano S, Doneda L, Vecchi M. Clinical features of type 1 and 2 refractory celiac disease: Results from a large cohort over a decade. Dig Liver Dis. 2023 Feb;55(2):235-242. doi: 10.1016/j.dld.2022.08.022. Epub 2022 Sep 10. PMID: 36096991.