Evolution Genetic evidence from comparisons of multiple organisms showed that a glutathione-dependent formaldehyde dehydrogenase, identical to a class III alcohol dehydrogenase (ADH-3/ADH5), is presumed to be the ancestral enzyme for the entire ADH family. Early on in evolution, an effective method for eliminating both endogenous and exogenous formaldehyde was important and this capacity has conserved the ancestral ADH-3 through time. Gene duplication of ADH-3, followed by series of mutations, led to the evolution of other ADHs.
evolution genetic evidence from comparisons of multiple organisms showed that a glutathione-dependent formaldehyde dehydrogenase identical to a class iii alcohol dehydrogenase (adh-3/adh5) is presumed to be the ancestral enzyme for the entire adh family early on in evolution an effective method for eliminating both endogenous and exogenous formaldehyde was important and this capacity has conserved the ancestral adh-3 through time gene duplication of adh-3 followed by series of mutations led to the evolution of other adhs