16th century The exile of the Medici lasted until 1512, after which the "senior" branch of the family—those descended from Cosimo the Elder—were able to rule until the assassination of Alessandro de' Medici, first Duke of Florence, in 1537. This century-long rule was interrupted only on two occasions (between 1494–1512 and 1527–1530), when anti-Medici factions took control of Florence. Following the assassination of Duke Alessandro, power passed to the "junior" Medici branch—those descended from Lorenzo the Elder, the youngest son of Giovanni di Bicci, starting with his great-great-grandson Cosimo I "the Great".
16th century The exile of the Medici lasted until 1512 after which the "senior" branch of the family—those descended from Cosimo the Elder—were able to rule until the assassination of Alessandro de' Medici, first Duke of Florence, in 1537. This century-long rule was interrupted only on two occasions (between 1494–1512 and 1527–1530) when anti-Medici factions took control of Florence. Following the assassination of Duke Alessandro, power passed to the "junior" Medici branch—those descended from Lorenzo the Elder, the youngest son of Giovanni di Bicci, starting with his great-great-grandson Cosimo I "the Great".