In 2023, it is reported that phthalic anhydride and L-glutamine under suitable conditions can react directly to form thalidomide. In the procedure, phthalic anhydride and L-glutamine are grounded and added into toluene solvent. The solution, along with triethylamine and acetic anhydride, is refluxed at ~110°C for 9 hours; after that the solution goes through a simple vacuum filtration procedure to obtain the product.
In 2023, it is reported t.hat phthalic anhydride and L-glutamine under suitable conditions can react directly to form thalidomide In the procedure, phthalic anhydride and L-glutamine are grounded and added into toluene solvent The solution, along with triethylamine and .acetic anhydride, is refluxed at ~110°C for 9 hours; after that the solution goes through a simple vacuum filtration procedure to obtain the product.