Lymphomagenesis in primary Sjögren's syndrome patients is considered as a multistep process, with the first step being chronic stimulation of autoimmune B cells, especially B cells that produce rheumatoid factor at sites targeted by the disease. This increases the frequency of oncogenic mutation, leading to any dysfunction at checkpoints of autoimmune B-cell activation to transform into malignancy. A study's finding has concluded the continuous stimulation of autoimmune B cells, leading to subtle germinal abnormalities in genes having specific consequences in B cells, which underlies the susceptibility to lymphoma.
lymphomagenesis in primary sjögren's syndrome patients is considered as a multistep process with the first step being chronic stimulation of autoimmune b cells especially b cells that produce rheumatoid factor at sites targeted by the disease this increases the frequency of oncogenic mutation leading to any dysfunction at checkpoints of autoimmune b-cell activation to transform into malignancy a study's finding has concluded the continuous stimulation of autoimmune b cells leading to subtle germinal abnormalities in genes having specific consequences in b cells which underlies the susceptibility to lymphoma