thumb|The disc of Enheduanna. Enheduanna, the daughter of Sargon of Akkad, was a particularly famous en priestess. She is also the earliest attested holder of this office, with available evidence including the so-called "disc of Enheduanna", seals of her servants, and literary compositions copied in later periods traditionally attributed to her. It is it not certain if the office of en was only established at this point in time as an innovation, or if it developed from an earlier Early Dynastic title tied to the cult of the moon god. Later en priestesses include , daughter of Sargon's grandson Naram-Sin of Akkad (named as "zirru priestess of the god Nanna, spouse of the god N[anna], entu priestess of the god Sin at Ur"); Enannepada, daughter of Ur-Baba of Lagash and the only holder of this office from the Second Dynasty of Lagash; , daughter of Ur-Nammu of Ur; , a contemporary and possibly daughter of Shulgi; her successors Enuburzianna and Enmahgalana, the former also selected during the reign of Shulgi and the latter shortly after by Amar-Sin; , daughter of Ishme-Dagan of Isin who retained her position after his death and conquest of the city of Ur by Larsa; Enšakiag-Nanna, daughter of Sumuel of Larsa; and her successor , daughter of Kudur-Mabuk of Larsa and sister of Warad-Sin and Rim-Sîn I. She was the last known holder of this office before its revival of in the Neo-Babylonian period.
thumb|the disc of enheduanna enheduanna the daughter of sargon of akkad was a particularly famous en priestess she is also the earliest attested holder of this office with available evidence including the so-called "disc of enheduanna" seals of her servants and literary compositions copied in later periods traditionally attributed to her it is it not certain if the office of en was only established at this point in time as an innovation or if it developed from an earlier early dynastic title tied to the cult of the moon god later en priestesses include  daughter of sargon's grandson naram-sin of akkad (named as "zirru priestess of the god nanna spouse of the god n[anna] entu priestess of the god sin at ur"); enannepada daughter of ur-baba of lagash and the only holder of this office from the second dynasty of lagash;  daughter of ur-nammu of ur;  a contemporary and possibly daughter of shulgi; her successors enuburzianna and enmahgalana the former also selected during the reign of shulgi and the latter shortly after by amar-sin;  daughter of ishme-dagan of isin who retained her position after his death and conquest of the city of ur by larsa; enšakiag-nanna daughter of sumuel of larsa; and her successor  daughter of kudur-mabuk of larsa and sister of warad-sin and rim-sîn i she was the last known holder of this office before its revival of in the neo-babylonian period