Mortality Published studies on the survival of Sjögren's syndrome patients have been limited in varied respects, perhaps owing to the relatively small sample sizes, and the fact that secondary Sjögren's syndrome is associated with other autoimmune diseases. A 2010 study found a slight increase in mortality rates of Sjögren's patients in comparison with the remainder of the population. A 2016 study found that primary Sjögren's was not associated with an increase in all-cause mortality as compared with the general population, but that a subset of patients with extraglandular involvement, vasculitis, hypocomplementaemia and cryoglobulinaemia may be at increased risk of mortality. A 2021 metaanalysis showed a 46% increase in mortality, with significantly greater mortality risk in patients with older age, male gender, vasculitis, interstitial lung disease, low complements, positive anti-La/SSB and cryoglobulinaemia.
mortality published studies on the survival of sjögren's syndrome patients have been limited in varied respects perhaps owing to the relatively small sample sizes and the fact that secondary sjögren's syndrome is associated with other autoimmune diseases a 2010 study found a slight increase in mortality rates of sjögren's patients in comparison with the remainder of the population a 2016 study found that primary sjögren's was not associated with an increase in all-cause mortality as compared with the general population but that a subset of patients with extraglandular involvement vasculitis hypocomplementaemia and cryoglobulinaemia may be at increased risk of mortality a 2021 metaanalysis showed a 46% increase in mortality with significantly greater mortality risk in patients with older age male gender vasculitis interstitial lung disease low complements positive anti-la/ssb and cryoglobulinaemia