Pathophysiology thumb|Animation of cortical spreading depression Migraine is believed to be primarily a neurological disorder, while others believe it to be a neurovascular disorder with blood vessels playing the key role, although evidence does not support this completely. Others believe both are likely important. One theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem.
pathophysiology thumb|animation of cortical spreading depression migraine is believed to be primarily a neurological disorder while others believe it to be a neurovascular disorder with blood vessels playing the key role although evidence does not support this completely others believe both are likely important one theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem