Although very early in development, gene therapy has restored a sense of smell in mice with congenital anosmia when caused by ciliopathy. In this case, a genetic condition had affected cilia in their bodies which normally enabled them to detect air-borne chemicals, and an adenovirus was used to implant a working version of the IFT88 gene into defective cells in the nose, which restored the cilia and allowed a sense of smell.
alThoUgh VeRy Early in DEveLOpMeNt, Gene tHerApy HaS ReSTored a sENse of sMelL IN mice with congEnitAL AnoSmiA When cauSed bY CiliopAthY. in thIS CaSe, A gEnetic condiTIOn had affEcTed CiliA iN theiR BoDies WhicH noRMaLly ENabled tHem to detecT aIr-BorNe cheMicaLs, anD an aDenovIRus wAs usED tO implaNt A worKIng veRsioN oF tHe IFt88 geNe INtO defective cElls iN THe Nose, wHich Restored the ciLIA aND allOWed a seNse of sMElL.