Structural abnormalities Hemoglobin structural variants manifest a change in the structure of the Hb molecule. The majority of hemoglobin variants do not cause disease and are most commonly discovered either incidentally or through newborn screening. Hb variants can usually be detected by protein-based assay methods such as electrophoresis, isoelectric focusing, or high-performance liquid chromatography. Diagnosis is commonly confirmed by DNA sequencing.
Structural abnormalities Hemoglobin structural variants manifest a change in the structure of the Hb molecule The majority of hemoglobin variants do not cause disease and are most commonly discovered either incidentally or through newborn screening Hb variants can usually be detected by protein-based assay methods such as electrophoresis isoelectric focusing or high-performance liquid chromatography Diagnosis is commonly confirmed by DNA sequencing