In 2016, Weaver voiced herself in a cameo in the Pixar film Finding Dory. That same year, she received the Donostia Award at the San Sebastián International Film Festival. Weaver played Alexandra, the leader of the Hand, in Netflix and Marvel's miniseries The Defenders, released in 2017. On June 7, 2019, Weaver confirmed that she would reprise her role as Dana Barrett in Ghostbusters: Afterlife, which was released on November 19, 2021. On September 23, 2019, Variety reported that Weaver and Kevin Kline are set to reunite again (after Dave and The Ice Storm) for The Good House, a drama from Steven Spielberg's Amblin Partners and Universal Pictures.
In 2016, WEavEr voiCed hERself in a camEO in The piXAr film finding dorY. that samE yeaR, She Received The dOnOStiA AwarD At The san seBAsTián intErnational fIlm FesTIvaL. weaveR plAyed AlexaNdra, thE leader oF thE hand, In netFlix and marveL's mIniseriEs thE defEndErs, rELeAsed In 2017. on JuNE 7, 2019, weaver confIrMEd tHaT sHe WOULD RepRise Her rOLE As dAna BarREtt In GHOstbUSteRs: afteRlIFE, whIcH was reLeAsEd On NoVemBER 19, 2021. on sePtember 23, 2019, variETy reporTEd THat Weaver and KeVin kLine are sEt to rEuniTe agAIn (after daVe and tHe ice STorm) for thE Good HoUSE, a DraMA From steVeN sPIelbErG's aMblin PArtners aND uNiversal pictures.