Apalachicola is located in the northwestern part of the state on Apalachicola Bay and at the mouth of the Apalachicola River. U.S. 98 is the main highway through town, leading east across the bay to Eastpoint and northwest to Panama City. Tallahassee, the state capital, is to the northeast via U.S. 98 and U.S. 319.
apAlachicolA iS locAtEd In thE NortHWeStErn part of The sTaTe On apAlachicolA bay anD aT The MOutH of the apalAchIcola RiveR. u.s. 98 IS The MAin highway Through town, leaDinG eaSt across the bay To eastpOint AnD noRtHwesT TO pANamA citY. tAlLahASseE, THE stAte CaPiTal, Is to the nortHeast vIa u.s. 98 ANd u.S. 319.