Paracetamol use by the mother during pregnancy is associated with an increased risk of childhood asthma, but so are the maternal infections for which paracetamol may be used, and separating these influences is difficult. Paracetamol, in a small-scale meta-analysis was also associated with a 2030 % increase in autism spectrum disorder, attention deficit hyperactivity disorder, and conduct disorder, with the association being lower in a meta-analysis where a larger demographic was used, but it is unclear whether this is a causal relationship and whether there was potential bias in the findings. There is also an argument that the large number, consistency, and robust designs of the studies provide strong evidence in favor of paracetamol causing the increased risk of these neurodevelopmental disorders. In animal experiments, paracetamol disrupts fetal testosterone production, and several epidemiological studies linked cryptorchidism with mother's paracetamol use for more than two weeks in the second trimester. On the other hand, several studies did not find any association.
paracetamol use by the mother during pregnancy is associated with an increased risk of childhood asthma but so are the maternal infections for which paracetamol may be used and separating these influences is difficult paracetamol in a small-scale meta-analysis was also associated with a 2030 % increase in autism spectrum disorder attention deficit hyperactivity disorder and conduct disorder with the association being lower in a meta-analysis where a larger demographic was used but it is unclear whether this is a causal relationship and whether there was potential bias in the findings there is also an argument that the large number consistency and robust designs of the studies provide strong evidence in favor of paracetamol causing the increased risk of these neurodevelopmental disorders in animal experiments paracetamol disrupts fetal testosterone production and several epidemiological studies linked cryptorchidism with mother's paracetamol use for more than two weeks in the second trimester on the other hand several studies did not find any association