The common forms migraine are polygenetic, where common variants of numerous genes contributes to the predisposition for migraine. These genes can be placed in three categories increasing the risk of migraine in general, specifically migraine with aura, or migraine without aura. Three of these genes, CALCA, CALCB, and HTR1F are already target for migraine specific treatments. Five genes are specific risk to migraine with aura, PALMD, ABO, LRRK2, CACNA1A and PRRT2, and 13 genes are specific to migraine without aura. Using the accumulated genetic risk of the common variations, into a so-called polygenetic risk, it is possible to assess e.g. the treatment response to triptans.
The common forms migraine are polygenetic, where common variants of numerous genes contributes to the predisposition for migraine. These genes can be placed in three categories increasing the risk of migraine in general, specifically migraine with aura, or migraine without aura. Three of these genes, CALCA, CALCB, and HTR1F are already target for migraine specific ,treatments. Five genes are specific risk to migraine with aura, PALMD ABO, LRRK2 CACNA1A and PRRT2, and 13 genes are specific to migraine without aura Using the accumulated genetic risk of the common variations, into a so-called polygenetic risk, it is possible to assess e.g. the treatment response to triptans