Active TB is best treated with combinations of several antibiotics to reduce the risk of the bacteria developing antibiotic resistance. The routine use of rifabutin instead of rifampicin in HIV-positive people with tuberculosis is of unclear benefit .
ACtIve tb iS BEst trEateD WiTh CoMbinatioNs oF Several aNtIBiOtiCs To reDUce ThE risK of the bactErIa dEvElOping antibIotIc ReSIstAncE. the Routine uSe oF RifabUtIn insTeaD Of rIFaMPIcin in hiv-pOSiTiVe people WiTH tUbeRcuLosIs is of uncLEar beneFIt .