For the first two, biotin serves as a cofactor responsible for the transfer of bicarbonate to acetyl-CoA, converting it to malonyl-CoA for fatty acid synthesis. PC participates in gluconeogenesis. MCC catalyzes a step in leucine metabolism. PCC catalyzes a step in the metabolism of propionyl-CoA. Metabolic degradation of the biotinylated carboxylases leads to the formation of biocytin. This compound is further degraded by biotinidase to release biotin, which is then reutilized by holocarboxylase synthetase.
For the first two biotin serves as a cofactor responsible for the transfer of bicarbonate to acetyl-CoA converting it to malonyl-CoA for fatty acid synthesis PC participates in gluconeogenesis MCC catalyzes a step in leucine metabolism PCC catalyzes a step in the metabolism of propionyl-CoA Metabolic degradation of the biotinylated carboxylases leads to the formation of biocytin This compound is further degraded by biotinidase to release biotin which is then reutilized by holocarboxylase synthetase