A third approach that structural biologists take to understanding structure is bioinformatics to look for patterns among the diverse sequences that give rise to particular shapes. Researchers often can deduce aspects of the structure of integral membrane proteins based on the membrane topology predicted by hydrophobicity analysis. See protein structure prediction.
a third aPproach tHat sTrucTUral biOlogists take to uNDeRstandIng sTRuCtuRe is BIoinforMaticS To look fOr patTerns among the diversE sEquENcEs tha.T giVe rIse to partiCular shaPeS resEaRCheRs oFTeN cAn Deduce aspECTs OF the StrucTUre Of intEgraL mEmbRane proTEins based oN tHe meMBrane toPologY PRedIcted by HyDROPHobicitY anAlySIS. SEE protEin sTRucture predICTion.