Integral polytopic proteins are transmembrane proteins that span across the membrane more than once. These proteins may have different transmembrane topology. These proteins have one of two structural architectures: Helix bundle proteins, which are present in all types of biological membranes; Beta barrel proteins, which are found only in outer membranes of Gram-negative bacteria, and outer membranes of mitochondria and chloroplasts. Bitopic proteins are transmembrane proteins that span across the membrane only once. Transmembrane helices from these proteins have significantly different amino acid distributions to transmembrane helices from polytopic proteins. Integral monotopic proteins are integral membrane proteins that are attached to only one side of the membrane and do not span the whole way across.
Integral polytopic proteins are transmembrane proteins that span across the membrane more than once These proteins may have different transmembrane topology These proteins have one of two structural architectures Helix bundle proteins which are present in all types of biological membranes; Beta barrel proteins which are found only in outer membranes of Gram-negative bacteria and outer membranes of mitochondria and chloroplasts Bitopic proteins are transmembrane proteins that span across the membrane only once Transmembrane helices from these proteins have significantly different amino acid distributions to transmembrane helices from polytopic proteins Integral monotopic proteins are integral membrane proteins that are attached to only one side of the membrane and do not span the whole way across