14. The method of claim 13 wherein said step of applying a background correction comprises the steps of estimating a likelihood of the mutual information score, MI, for a given pair of genes, genes i and j, representing row or column i and row or column j of said adjacency matrix, by comparing the mutual information score, MI ij , for that pair to a background distribution of mutual information values.
14. The method of claim 13 wherein said step of applying a background correction comprises the steps of estimating a likelihood of the mutual information score, MI, for a given pair of genes, genes i and j, representing row or column i and row or column j of said adjacency matrix, by comparing the mutual information score, MI ij , for that pair to a background distribution of mutual information values. 15. The method of claim 14 wherein said background distribution is determined through a process comprising: i) providing two sets of MI values: {MI i }, the set of all mutual information values for gene i, in row or column i of said matrix; and {MI j }, the set of mutual information values for gene j, in row or column j of said matrix; and ii) calculating marginal empirical distribution P i and P j for each set of MI values using an empirical distribution estimation method, then combining into a joint empirical distribution.