6. The method of claim 1 , further comprising defining a plurality of groups of annotation types, the groups comprising different annotation types from each other.
6. The method of claim 1 , further comprising defining a plurality of groups of annotation types, the groups comprising different annotation types from each other. 7. The method of claim 6 , further comprising generating annotations for each of the variants in a plurality of parallel processes, the plurality of parallel processes corresponding to the plurality of groups.