7. The method of claim 1 , wherein the nucleotide sequence further comprises one or more regulatory regions for controlling transcription or translation of the wild-type prokaryotic MutS gene, or the mutant form of MutS gene.
7. The method of claim 1 , wherein the nucleotide sequence further comprises one or more regulatory regions for controlling transcription or translation of the wild-type prokaryotic MutS gene, or the mutant form of MutS gene. 8. The method of claim 7 , wherein the one or more regulatory regions comprises a constitutive promoter, a meiotic promoter, an S-phase promoter, a pre-meiotic S-phase promoter, a G2-phase promoter, or a preferentially meiotic promoter.