12. The method of claim 9 , wherein the determining and outputting an assertion is guided by the imaging decision support system.
9. A computer readable medium embodying instructions executable by a processor to perform a method for knowledge-based image computer aided detection, the method comprising: receiving an electronic patient record; determining and outputting an assertion relevant for the electronic patient record; detecting anatomical and functional structures in an input image corresponding to the electronic patient record based on the assertion and outputting an annotated image; and outputting a classification an annotated structure in the annotated image based on the assertion; and wherein the detecting anatomical and functional structures in input images is guided at least in part by the assertion.