15. A computer system for targeting a message response, the computer system comprising: one or more computer processors; one or more computer-readable storage media; program instructions stored on at least one of the one or more computer-readable storage media for execution by at least one of the one or more computer processors, the program instructions comprising: program instructions to monitor recipient activity related to one or more electronic messages received by a recipient; program instructions to gather recipient interest data, wherein gathering includes collecting one or more keywords that interest the recipient as evidenced by one or more positive indicators of interest associated with the one or more keywords; program instructions to store the one or more keywords within a database associated with the recipient; program instructions to calculate a recipient interest rating for each of the one or more keywords, wherein the recipient interest rating is based, at least in part, on the recipient activity and an established recipient interest baseline; in response to a sender drafting a subsequent electronic message addressed to the recipient, program instructions to compare the one or more keywords within a database associated with the recipient to a subject line and message content of the subsequent electronic message; and program instructions to suggest one or more alternative subject lines incorporating at least one of the one or more keywords stored within the database associated with the recipient, wherein suggesting the one or more alternative subject lines includes utilizing a predictive analytics system to determine a relative percentage increase in likelihood that the recipient will respond based on the one or more alternative subject lines.
16. The computer system of claim 15 , wherein program instructions to monitor recipient activity related to one or more electronic messages received by a recipient, comprise at least one of: program instructions to determine an order in which the one or more electronic messages are opened; program instructions to determine a length of time spent on each of the one or more electronic messages when opened; program instructions to determine a type of action taken on each of the one or more electronic messages; program instructions to determine a frequency of words used in the one or more electronic messages; program instructions to determine one or more affiliations of the recipient; program instructions to determine a type of words used in the one or more electronic messages; and program instructions to determine a format of words used in the one or more electronic messages.