1. An automated method for calibrating in real time a diagnostic analyzer, which comprises the steps of: receiving diagnostic results of patient samples calculated by the analyzer using pre-set parameters of the analyzer; calculating a centroid of the patient sample diagnostic results of the analyzer; comparing the centroid of the patient sample diagnostic results of the analyzer with a centroid of actual patient sample diagnostic results of a field population of comparable analyzers to determine a bias in the centroid of the patient sample diagnostic results of the analyzer; comparing the bias in the centroid of the patient sample diagnostic results of the analyzer with predetermined acceptable limits; if the bias of the centroid of the patient sample diagnostic results of the analyzer falls within the predetermined acceptable limits, then not applying an optimization factor to the patient sample diagnostic results calculated by the analyzer using the pre-set parameters of the analyzer; if the bias of the centroid of the patient sample diagnostic results of the analyzer falls outside the predetermined acceptable limits, then applying the optimization factor to the patient sample diagnostic results of the analyzer to obtain optimized patient sample diagnostic results; and outputting the optimized or un-optimized patient sample diagnostic results by the analyzer.