1. A process control system for controlling a process, comprising: a process simulator adapted to simulate the process and produce a simulated output of the process, wherein the simulated output includes one or more predicted future values of the process; an optimizer adapted to develop a set of target values based on measured inputs from the process and based on the simulated output from the process simulator; and a multiple-input/multiple-output controller adapted to produce, during each operational cycle of the process control system, multiple control outputs configured to control the process based on the set of target values provided to the multiple-input/multiple output controller from the optimizer during each operational cycle of the process control system.