1. A hybrid computational system comprising: at least one quantum processor comprising a plurality of qubits and a plurality of couplers; a configuration subsystem communicatively coupled to configure the at least one quantum processor, the configuration subsystem including at least one digital processor, and at least one non-transitory computer-readable storage medium communicatively coupled to the at least one digital processor and that stores at least one of processor-executable instructions or data, where in use the at least one digital processor: receives a problem Hamiltonian defined over at least two of the qubits, the problem Hamiltonian having a ground state that encodes a solution to a computational problem; during a first iteration on the computational problem: determines a plurality of change values for the problem Hamiltonian; updates the problem Hamiltonian to a new problem Hamiltonian using the plurality of change values; sends the new problem Hamiltonian to the at least one quantum processor; receives a changed solution set from the at least one quantum processor; and transforms the changed solution set to a solution set.