1. A lesion characterization system, including: a processor that receives anatomical image data for an image of a lesion volume, executes a segmentation protocol on the image data, and identifies intermediate segmentation results for the image data after one or more actions in the segmentation protocol are executed; a memory that stores at least the image data, and intermediate and final segmentation results; and a user interface on which at least the intermediate segmentation results and the final segmentation results are presented to a user for review; wherein the processor includes a segmentation comparator that calculates a rate of occurrence of non-enhanced voxels in the segmented image.