1. A method of performing contrast-enhanced medical imaging, the method including the steps of: a) prior to injection of a contrast agent to a subject, acquiring one or more baseline images of the subject; b) determining an average baseline image from the one or more baseline images; and after injection of the contrast agent to the subject; c) acquiring a post-injection image; d) generating at least one cumulative map including image data from previously measured post-injection images, the cumulative map further including a baseline correction based on the average baseline image; e) generating a histogram associated with the cumulative map; f) determining a quantity associated with the shape of the histogram and comparing the quantity to a pre-determined threshold; and g) repeating steps c) to f) until the quantity exceeds the pre-determined threshold.