1. A device for generating alternative of normal brain database to be used for diagnosing brain disease based on brain status images of subjects including patients, the alternative of normal brain database showing normal status of each points of brain, the device comprising: means for normalizing status value at each point of each brain status image of subject based on status values of a part or whole of brain status image of the subject; means for spatially transforming each brain status image of subject in accordance with anatomical standard brain; means for rejecting status values presumed as indicating disease with regard to each points of brain to be used for diagnosing disease based on said anatomically transformed and normalized brain status images of subjects; and means for generating the alternative of normal brain database by obtaining at least mean status value for said each point of brain to be used for diagnosing disease based on said anatomically transformed and normalized brain status images of subjects in which said status values presumed as indicating disease are rejected, wherein the rejecting means calculates the maximum value of deviation/standard deviation of status values of the plurality of subjects for each points as an ESD (extream studentized deviate), and rejects at least the status value selected as the ESD when the ESD exceeds a critical value λ calculated based on a predetermined risk α.