1. A method of operating a neurostimulation device, comprising: varying a first stimulation parameter under user control while fixing a second stimulation parameter; generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter; outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the plurality of stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation; changing the second stimulation parameter; varying the first stimulation parameter under user control while fixing the second changed stimulation parameter; generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter; outputting the pulsed electrical waveform from the neurostimulation device between the plurality of electrodes in accordance with the other plurality of stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.