1. A system comprising: an X-ray detector and an X-ray source operable to acquire first two-dimensional images of a patient volume using first imaging parameters and to acquire second two-dimensional images of the patient volume using second imaging parameters; an interface configured to: receive the first two-dimensional projection images; receive the second two-dimensional projection images; a processor configured to execute processor-executable program code that causes the processor to: generate, using a first image reconstruction technique, a first three-dimensional image based on the first two-dimensional projection images; receive from an input device one or more indications of features of the patient volume in the first three-dimensional image, the indications identified by an operator of the input device; generate, using a second image reconstruction technique, a second three-dimensional image based on the second two-dimensional projection images; perform automated feature extraction on the second three-dimensional image to automatically extract information associated with features of the patient volume; generate a feature report of the patient volume based on the one or more indications of features and the information associated with features; a display configured to display a two-dimensional slice image of the first three-dimensional image to the operator.