1. An electronic device for performing active biological operations, comprising: a support substrate having a first and second surface, and a via between the first and second surfaces to permit fluid flow through the substrate, the second surface supporting electrical traces, a second substrate including at least a first surface, the first surface being adapted to be disposed in facing arrangement with the second surface of the first substrate, the second substrate including electrically conductive traces connecting to an array of microlocations, the array being adapted to receive said fluid through the via, electrical interconnections disposed between the electrical traces on the second surface of the support substrate and the electrical traces on the first surface of the second substrate, sealant disposed between the second face of the support substrate and the first face of the second substrate, said sealant providing a fluidic seal by and between the first substrate and the second substrate, and a flowcell dispose on the first surface of the first substrate.