1. A method for early detection of localized exposure to an agent active on a biological population, the method comprising the steps of: collecting, for each data type of a plurality of different data types relevant for detecting exposure to the agent, a plurality of time series of data at a corresponding plurality of locations associated with the data type; generating measures of anomalous conditions at the plurality of locations for each of the plurality of different data types based on the plurality of time series and a temporal model for each data type; and performing cluster analysis on the measures of anomalous conditions to determine an estimated location and estimated extent of effects from the agent.