1. A medical system for improving memory or cognitive function in a subject comprising: a. an intracranial access device; b. a mapping means for locating a predetermined location in the brain; c. a deliverable amount of a small interfering RNA or vector encoding said small interfering RNA selected from one or more sequences coded from SEQ ID NOS:24-40; and d. a delivery means for delivering said small interfering RNA or vector encoding said small interfering RNA to said location of the brain from said intracranial access device.