1. A patient physiological information monitoring system, comprising: a plurality of patient monitoring devices that monitor physiological information from a patient and generate corresponding physiological signals; and a physiological information analyzer including one or more processors that processes the monitored physiological information and determines whether a physiological change is a clinically significant event or an artifact, the one or more processors being programmed to: receive the physiological signals from the patient monitoring devices; generate morphograms of one physiological signal versus another physiological signal from pairs of the received physiological signals within sampling intervals; apply a wavelet decomposition to each morphogram to compute a signature for each mapping morphogram; compare the morphogram signatures within and across the sampling intervals for a shape perturbation; and determine whether the shape perturbation is a result of a clinically significant change or an artifact.