1. A computer-implemented method for controlling a manufacturing process, the method comprising: receiving dependent variable data measured during the manufacturing process, the dependent variable data representative of values of a first set of process parameters observed by one or more sensors; receiving manipulated variable data measured during the manufacturing process from a plurality of process tools and predicted manipulated variable data representative of a second set of process parameters. determining at least one of a predicted score value, a multivariate statistic, or both based on at least the received data; and determining operating parameters of the manufacturing process based on at least the predicted score value, the multivariate statistic, or both.