1. A method for use in medical imaging, comprising the steps of: 1) immobilizing a patient with respect to an imaging reference frame; and 2) with said patient immobilized; a) acquiring first digital imaging information including a first region of interest using a first imaging modality; b) processing said first digital imaging information using a computer-based diagnostic tool to identify a feature for analysis; and c) based on said step of processing, using a second imaging modality different than said first imaging modality to acquire targeted second imaging information for a second region of interest, said second region of interest corresponding to a subset of said first region of interest, wherein said second region of interest includes said feature for analysis.