1. A method for evaluating phosphorylation of an array of proteins, comprising: 1) exposing an ion-sensitive field effect transistor (ISFET) to a protein phosphorylation reaction; and 2) detecting an electrical signal output from said ISFET; wherein the ISFET is integrated into a complementary metal-oxide semiconductor (CMOS); wherein a CMOS surface is coated with a chloroalkane compound; and wherein at least one protein comprising a protein tag involved in the protein phosphorylation reaction is deposited onto the CMOS surface by using nucleic-acid programmable protein array (NAPPA) technology.