1. A method of implementing a modified priority routing of an input/output (I/O) interruption, comprising: determining, by a processor, whether the I/O interruption is pending for a core; determining, by the processor, whether any of a plurality of guest threads of the core is enabled for guest thread processing of the interruption in response to determining that the I/O interruption is pending; determining, by the processor, whether at least one of the plurality of guest threads enabled for guest thread processing is in a wait state; and based upon determining that the at least one of the plurality of guest threads enabled for guest thread processing is in the wait state, routing, by the processor, the I/O interruption to a guest thread enabled for guest thread processing and in the wait state.