1. A method for therapy response assessment, the method comprising: obtaining a pre-therapy medical image of a patient, the pre-therapy medical image representing at least one lesion of the patient; obtaining a post-therapy medical image of the patient, the post-therapy medical image of the patient representing the at least one lesion of the patient; convolving, by a processor, the pre-therapy and post therapy medical images with a texture feature learned from training images; and classifying, by the processor, a therapy response of the lesion with a machine-learnt classifier with a result of the convolving as an input feature to the machine-learnt classifier.