1. A method of calibrating a neural interface system, comprising: detecting a set of multicellular signals emanating from a central nervous system of a patient using a sensor comprising a plurality of electrodes for chronic detection of the set of multicellular signals, while the patient imagines multiple movements; receiving the set of multicellular signals from the sensor on an interface and processing the set of multicellular signals to generate a processed signal, wherein the processing includes excluding a multicellular signal from the set of multicellular signals, and wherein the processed signal is generated using one or more calibration output parameters; transmitting the processed signal from the interface to a controlled device; receiving the processed signal on the controlled device, and entering into a lockout condition wherein the patient is prevented from controlling the controlled device prior to successfully completing the calibrating of the neural interface system and wherein a repeat calibration is required before the processed signals are transmitted to the controlled device.