1. A method for generating a synthetic two-dimensional mammogram with enhanced contrast for structures of interest, the method comprising: acquiring, with a medical scanner, a three-dimensional digital breast tomosynthesis volume having a plurality of voxels; generating a three-dimensional relevance map that encodes for the plurality of voxels a relevance of an underlying structure for a diagnosis; and calculating a synthetic two-dimensional mammogram based on the three-dimensional digital breast tomosynthesis volume and the three-dimensional relevance map, wherein calculating the synthetic two-dimensional mammogram is based on ray-casting in the generated three-dimensional relevance map and the acquired three-dimensional digital breast tomosynthesis volume.