1. A method for altering one or more parameters of a measurement system, comprising: analyzing a sample using the system to generate values from classification channels of the system for a population of particles in the sample; identifying a region in a classification space in which the values for the population are located; and determining an optimized classification region for the population using one or more properties of the values of the population, wherein the optimized classification region contains a predetermined and fixed percentage of the values for the population, wherein the optimized classification region is used for classification of particles in additional samples, and wherein the one or more properties of the values of the population comprise an average, mean, peak, or median of the values of the population and a standard deviation of the values of the population.