1. A method of spatially segmenting an anatomical structure from 3-D medical image data, comprising: receiving the 3-D medical image data, and a plurality of grid locations from within a section of the 3-D medical data, the section including a sub-portion of the anatomical structure; determining a first seed selection, based on the grid locations and the section; determining a partial segmentation of the anatomical structure within the section, based on the first seed selection; determining a second seed selection, based on the location of the partial segmentation within the 3-D medical image data; and determining a 3-D segmentation of the anatomical structure, based on the second seed selection and the 3-D medical image data.