1. A method of Coupled Neuraxial Mesoscopic Desynchronization Electrostimulation Therapy (cNMDET) for applying ambulatory, non-invasive therapeutic electrostimulatory modalities, comprising mechanisms of action that are reparative, palliative and support adaptive recovery, in a preferred embodiment utilizing Coupled Neuraxial Transcutaneous Electrical Nerve Stimulation (cNTENS) and Coupled Neuraxial Transcranial Direct Stimulation (ctDCS n ), wherein the electrostimulatory modalities are configured to treat both acute and chronic pain, the method comprising; placing a combination of at least two progressively sequenced electrodes on clinically targeted nerve areas, wherein the clinically targeted nerve areas establish a targeted neural pathway, the targeted neural pathway including at least one of; a) central nervous system (CNS) sites, b) underlying contributory clinicopathologic mechanisms of autonomic nervous system (ANS) sites and c) clinically involved components of peripheral nervous system (PNS) sites; wherein the CNS sites are comprised of brain regions, spinal cord regions and intervening structures; applying therapeutic electrostimulation along a longitudinally coursing path of the targeted neural pathway, wherein the longitudinally coursing path consists of targeted neural system pathways, and wherein an additional combination of progressively sequenced electrostimulation electrodes further includes a patterned placement of the additional electrostimulation electrodes in an array of electrodes configured to treat involved joints, muscles, fascia, ligaments, tendons and areas involved in an inflammatory process.