1. A process control system for controlling a process, comprising: a multiple-input/multiple-output controller adapted to produce, during each operational cycle of the process control system, multiple control outputs configured to control the process based on multiple measured inputs from the process and based on a set of target values provided to the multiple-input/multiple output controller during each operational cycle of the process control system; and an optimizer adapted to develop the set of target values for use by the multiple-input/multiple-output controller during each operational cycle of the process control system.