1. A system for managing patient data comprising: a computing system including a processing unit and a storage, the processing unit executing one or more programs for managing patient data, where managing patient data includes enrolling patients in a centralized care network including presenting each patient with an electronic enrollment interface, assigning each patient a patient identifier, and receiving an electronic consent to collect data; providing patient data to the centralized care network including patient data relating to disease progression, clinical trials and treatments rendered; receiving a treatment regimen, from among a plurality of treatment regimens available to treat a given patient, the treatment regimen based at least in part on the patient data including a molecular profile, a current clinical characterization of the patient and evidence based data; processing the received treatment regimen including monitoring clinical outcome of the given patient after application of the treatment regimen, and based at least in part on the clinical outcome, enabling an update to the treatment regimen including providing clinical outcome data to the centralized care network; and receiving an updated treatment regimen, from among a plurality of treatment regimens available to treat a given patient, the updated treatment regimen based at least in part on the patient data including a molecular profile, a current clinical characterization of the patient, evidence based data and the clinical outcome data.