1. A method for a managed pressure drilling (MPD) operation, comprising: designing a MPD drilling system comprising a rotating control device (RCD), a drilling string non-return valve (NRV), and a choke manifold; providing a first reliability model for a probability of a failure mode of the MPD operation; assessing the probability of the failure mode based on the first reliability model; and devising a first well control scheme to detect the failure mode assessed based on the first reliability model, wherein the first reliability model is chosen from a Failure Modes and Effects Analysis (FMEA), Fault Tree Analysis (FTA), Ishikawa diagram, Pareto Chart, Reliability Block Diagram (RBD), and combinations thereof.