1. A method programmed in a non-transitory memory of a device comprising: performing whole tumor segmentation, wherein the whole tumor segmentation includes: utilizing multi-modal MRIs including T1, T1c, Flair and T2; determining a least-tumor hemisphere; classifying tissue; identifying intensity control points based on intensities of different tissue structures; normalizing the intensity for each of the MRIs based on the intensity control points; locating initial tumor seeds; and segmenting a tumor based on the tumor seeds; and performing multi-class tumor segmentation.