1. An image reconstruction method, comprising: selecting a particular X and Y location corresponding to one or more selected voxels in an image volume; iteratively selecting one or more Z locations for the particular X and Y location, wherein the selected Z locations combined with the particular X and Y location correspond to the one or more selected voxels; pre-computing one or more partial sums corresponding to channel dependent portions of a separable system model associated with the particular X and Y location; computing row-dependent portions of the separable system model, wherein computing the row-dependent portions of the separable system model is independent of the pre-computing the one or more partial sums; combining the one or more partial sums and the row-dependent portions of the separable system model to compute corresponding updates for the one or more selected voxels; updating the one or more partial sums to be consistent with the computed updates for the one or more selected voxels; and applying the computed updates to the one or more selected voxels, wherein applying the computed updates is independent of updating the one or more partial sums corresponding to the one or more selected voxels.