1. A computer program product comprising a computer usable medium having a computer readable program, wherein the computer readable program, when executed on computing device, causes the computing device to: receive an input/output (I/O) request from an application instance, wherein the I/O request includes a key value for identifying an entry in a translation protection table data structure, and wherein the I/O request targets a portion of a storage device in a remotely located storage system upon which an I/O operation is to be performed; retrieve an entry from a translation protection table based on the key value, wherein the entry includes an identifier of the storage device and a logical unit number corresponding to the portion of the storage device targeted by the I/O request; generate a storage command based on the identifier of the storage device and the logical unit number retrieved with the entry from the translation protection table; and place the storage command in a storage command queue for transmission to the remotely located storage system.