1. A computerized image guided pre-colony selection method comprising the steps of: a) Input at least one pre-colony cell image; b) Perform pre-colony region recognition using the pre-colony cell image to generate pre-colony region context output; c) Perform pre-colony region context measurement using the pre-colony region context to generate at least one pre-colony region context feature output; d) Perform pre-colony decision using the pre-colony region context feature to generate pre-colony selection decision output.