1. A non-transitory computer-readable storage medium storing computer executable instructions that when executed by a computer control the computer to perform a method for detecting cancerous pathology in a region of tissue, the method comprising: accessing an image of a region of tissue demonstrating cancerous pathology, where the image comprises a set of tiles; generating a tile sampling selection, where the tile sampling selection defines a sampling subset of the set of tiles, where the number of tiles in the sampling subset is N, where N is less than the number of tiles in the set of tiles, N being an integer; upon determining that a termination condition has not been met: extracting the sampling subset from the image based on the tile sampling selection; providing the sampling subset to an automated classifier; receiving, from the automated classifier, a prediction probability based, at least in part, on the sampling subset, where the prediction probability indicates the probability of invasive pathology at a location in the image occupied by a tile; constructing a probability map of the region of tissue based on the prediction probability or the sampling subset; computing a gradient of the probability map; and updating the tile sampling selection based on the gradient of the probability map; upon determining that the termination condition has been met: constructing a final probability map based, at least in part, on the probability map; and controlling a computer aided diagnosis (CADx) system to generate a classification of the region of tissue based, at least in part, on the final probability map.