1. A computer-implemented method of anatomical modeling, the method comprising: receiving image data of one or more blood vessels of a patient, the image data being obtained while the patient's body is at a first physiological state; determining, using a processor, a patient-specific anatomic model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state; determining a patient-specific biomechanical model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state; determining a second physiological state of the patient's body different from the first physiological state, wherein the second physiological state includes a hyperemic state, an exercise state, or a medicated state; determining one or more parameters associated with the second physiological state of the patient's body; and updating the anatomic model by incorporating one or more geometric changes associated with the one or more parameters of the second physiological state of the patient's body and the biomechanical model.