1. A chemical detection device, comprising: a substrate of a first semiconductor type; and a chemical detection pixel including: a chemically-sensitive field effect transistor formed in the substrate, the chemically-sensitive field effect transistor having a floating gate structure and a body terminal, the body terminal coupled to a body biasing voltage source line; a first switch consisting of a first field effect transistor formed in the substrate; a second switch consisting of a second field effect transistor formed in the substrate; wherein a channel of the chemically-sensitive field effect transistor, a channel of the first field effect transistor and a channel of the second field effect transistor are each a same semiconductor type; and a passivation layer formed over the floating gate structure.