1. A computer network comprising: a plurality of affiliate computing systems, each affiliate computing system including a processing unit and storage, the processing unit executing one or more programs for supporting care of a patient, where supporting includes enrolling patients in a centralized care network including assigning each patient a patient identifier, and receiving consent to collect data; and providing patient data to the centralized care network including patient data relating to one or more of disease progression, clinical trials or treatments rendered; and the centralized care network including a central health care computing system, the central health care computing system being coupled to each affiliate computing system by way of a network, the central health care computing system including a processing unit and storage, the processing unit executing one or more programs for managing patient records stored in the storage, where managing patient records includes receiving patient data from an affiliate computing system including new data for new patients and updated patient data reflecting new or changing data with respect to an already registered patient; tracking patients over time to develop longitudinal data relating to treatments and outcomes; developing treatment protocols based on the longitudinal data for treating future patients enrolled in the centralized care network, wherein developing treatment protocols further comprises developing at least one treatment protocol based on the longitudinal data and updating the at least one treatment protocol based at least in part on assessments of patients after treatment in accordance with a given treatment protocol; and distributing developed treatment protocols to one or more of the affiliate computing systems for use in treating future patients serviced by a treatment center associated with a given affiliate computing system, wherein distributing developed treatment protocols includes identifying a treatment protocol, from among the treatment protocols, for a patient based at least in part on a molecular profile, a current clinical characterization and the longitudinal data.