1. A channel estimation method with channel adaptation for receiving an input signal comprising a plurality of input symbols each comprising a plurality of pilot signals, wherein the channel estimation method comprises: receiving an n-th input symbol of the input signal, and obtaining a plurality of the pilot channel gains by calculating a plurality of pilot channels transmitting the pilot signals of the n-th input symbol, wherein n is a natural number; executing an operation of interpolation on the pilot channel gains by a Wiener filter to obtain a plurality of data channel gains, corresponding to a plurality of data channels transmitting a plurality of respective data signals of the n-th input symbol; calculating an adaptive alteration for a first and a second multi-path statistical characteristic parameters according to the data channel gains and the pilot channel gains, and accordingly having the first and the second multi-path statistical characteristic parameters adjusted; generating an updated Wiener filter according to the adjusted first and second multi-path statistical characteristic parameters; and after generating the updated Wiener filter, increasing the value of n by 1 and repeating the operation of channel estimation to execute an operation of channel estimation on a next input symbol of the input signal.