1. A method of reducing oxidative stress in a subject suffering from Alzheimer's, the method comprising: (a) identifying a subject suffering from Alzheimer's and (b) administering to the subject an effective amount of a formulation comprising an isolated nucleic acid comprising a first sequence that encodes ASPA under conditions whereby the nucleic acid is expressed in a host cell of the subject and whereby expression of ASPA leads to enhanced catabolism of NAA, increased concentration of AcCoA, and reduced oxidative stress.