1. A computer program product for performing a frame management function in a computer system of a machine architecture, the computer system configured to perform dynamic address translation (DAT) using a hierarchy of DAT translation tables to obtain any one of an absolute address of a large block of main storage or a real address of a small block of main storage, wherein a real address is subject to prefixing to form an absolute address, each block of main storage having an associated storage key separate and distinct from any of said DAT translation tables, the computer program product comprising: a storage medium readable by said computer system, said computer readable medium storing instructions for performing: obtaining a machine instruction comprising an opcode for a perform frame management function instruction, the machine instruction further comprising a first register field identifying a first general register and a second general register field identifying a second general register; and executing a clear-frame operation of said machine instruction comprising: obtaining, from said first general register, clear frame information comprising a frame size field indicating whether a storage frame is any one of a small block of main storage or a large block of main storage; obtaining, from said second general register, an operand address of said storage frame, said operand address comprising any one of an address of said small block of main storage or an address of an initial sub-block of said large block of main storage, said large block of main storage consisting of a plurality of contiguous sub-blocks of main storage; based on said operand address, in response to said indicated storage frame being said small block of main storage, clearing said small block of main storage, wherein said clearing sets all bytes of the small block of main storage to zero; and based on said operand address, in response to said indicated storage frame being said large block of main storage, clearing a range of one or more sub-blocks of said plurality sub-blocks of main storage, said range beginning with said initial sub-block of main storage, wherein said clearing sets all bytes of the range of sub-blocks of main storage to zero.