1. A method for segmenting an image series of at least one image of a region of interest of a subject, comprising: generating a plurality of eigenimages for the image series, the generating including extracting at least one motion region of the region of interest as the plurality of eigenimages; registering at least one reference eigenimage to a training model of the region of interest, the at least one reference eigenimage being based on at least one eigenimage of the plurality of eigenimages and the training model including at least one segmented image of the region of interest; segmenting each image, the segmenting including applying a localized region based level set function; and outputting each segmented image.