1. A method of enhancing a refresh PCI translation (RPCIT) instruction to refresh a translation lookaside buffer (TLB), the method comprising: communicating a PCI command response block including at least one of a single-frame (SF) control bit field and a synchronization bypass (SB) control bit field; determining a single-frame TLB refresh operation is available based on a SF control bit existing in the SF control bit field; when the SF control bit indicates that the single-frame TLB refresh operation is available, determining, by a computer processor, a request to purge a translation for a single frame of the TLB in response to executing an enhanced RPCIT instruction configured to selectively perform one of the single-frame TLB refresh operation and a range-bounded TLB refresh operation; determining, by the computer processor, an absolute storage frame based on a translation of a PCI virtual address in response to the request to purge a translation for a single frame of the TLB; and performing, by the computer processor, the single-frame TLB refresh operation to purge the translation for the single frame.