1. A method, comprising; a) contacting deoxyribonucleic acid with a cross-linking agent under conditions such that interacting chromatin segments are cross-linked; b) digesting said cross-linked chromatin segments to generate digested chromatin segments; c) ligating said digested chromatin segments to generate a first genomic interaction library comprising a plurality of ligation products; d) contacting said plurality of ligation products with a plurality of unique primers under conditions such that ligation mediated amplification generates a second genomic interaction library that is a copy of a part of said first genomic interaction library; and e) amplifying said second genomic library with a single pair of PCR primers.