1. An assisted decision-making system that generates and evaluates a plurality of courses of action (COAs) for a problem of interest having an associated set of problem characteristics, comprising: a case based reasoner that generates an initial set of courses of action, each course of action comprising a plurality of COA packages and a set of associated fitness parameters, according to the associated problem characteristics; a genetic algorithm that refines the initial set of courses of action, according to a set of global influence values, to produce at least one optimized course of action; and a user interface that allows a user to adjust at least one value from the set of global influence values and the set of fitness parameters associated with each optimized course of action.