1. A method for resolving a discrepancy arising in a clinical data management system (CDMS), the method comprising: converting the discrepancy from a back-end format, used to store a clinical value corresponding to said discrepancy, into a front-end format that is compatible with a front-end study definition; transferring said discrepancy, in said front-end format, to a front-end site where the clinical value associated with said discrepancy was entered; receiving a discrepancy response from said front-end site; and when said discrepancy response resolves said discrepancy, storing said discrepancy response.