1. A method, comprising: receiving, by a prefetch optimizer tool of an information handling system (IHS), an instruction sequence of interest including a plurality of instructions with respective software prefetch instructions in advance of particular load instructions; instructing, by the prefetch optimizer tool, a hardware prefetch mechanism in a processor of the IHS to fetch instructions from a memory store to one of a plurality of hardware prefetch depths; disabling, by the prefetch optimizer tool, particular prefetch instructions in the instruction sequence of interest; measuring, by the prefetch optimizer tool, execution times of the instruction sequence of interest when the particular prefetch instructions are disabled, the measuring being conducted by the prefetch optimizer tool while the hardware prefetch mechanism is set to a particular prefetch depth; and changing, by the prefetch optimizer tool, the hardware prefetch depth of the hardware prefetch mechanism to another hardware prefetch depth and repeating the measuring of the execution times of the instruction sequence of interest while disabling different particular fetch instructions in the instruction sequence of interest.