1. A method of modifying feature intensity of image data from a biological probe array comprising: a. obtaining one or more sample image data of a feature comprising a set of observed pixel values from a biological probe array; b. determining a theoretical pixel intensity with a transfer function representing the proportion of the intensity in a set of pixels due to a feature, a feature intensity of said feature, and a background value of said feature; c. determining an optimized multiplicative error function using a multiplicative error function and a standard deviation function, wherein said multiplicative error function comprises said theoretical pixel intensity and said set of observed pixel values; and d. determining said feature intensity with an update rule for said feature intensity using a weight function representing the weight of said pixel and the optimized multiplicative error function where said update rule for said feature intensity iteratively generates a unique value to which said feature intensity converges.