1. A computer-implemented method comprising: receiving, by a computer processor, user input selecting a neuromodulation effect region of a patient; and responsive to the input, determining, by the processor, electrode neuromodulation settings estimated by the processor to, when applied to an implanted electrode leadwire, produce a volume of tissue activation that at least partially encompasses at least one target anatomical stimulation candidate region which is mapped by the processor to, and is at a distance from, the selected neuromodulation effect region; wherein at least one of: the leadwire is implanted in the patient's brain; the at least one target anatomical stimulation candidate region includes a plurality of distinct regions; the user input specifies the neuromodulation effect region as a region at which neural activity is to be reduced; and the mapping at least one of: is based on a susceptibility weighted imaging (SWI) image; is based on a probabilistic tractography model; and includes a patient-specific mapping that is specific to the patient and that is based on response information indicating prior responses by the patient to previous neuromodulations.