1. A method of treating a target tissue region of a patient's body, comprising: exposing the target tissue region to a therapeutic x-ray radiation beam; introducing a hyperthermic probe into contact with the target tissue region; operating the probe to increase the temperature of the target tissue region, thereby facilitating a therapeutic effect of the radiation beam; acquiring image data of the probe while in contact with the target tissue region, the image data containing a fiducial datum; determining a position of the target tissue region within a treatment coordinate system based on the fiducial datum; and spatially adjusting the radiation beam relative to the target tissue region based on the determined position of the target tissue region.