1. A method for at least one of creating or modifying an anatomical structure mask, comprising: obtaining a first region of interest from at least one first image associated with at least one first subject; obtaining a second region of interest from at least one second image associated with at least one second subject; selectively analyzing each of the first and second regions of interest using an iterative procedure; determining a percentage of an overlap region that is common to the first and second regions of interest based on a predetermined criteria; determining a particular ratio of sensitivity to specificity for each of the first and second regions of interest; and using a computing arrangement, at least one of creating or modifying the anatomical structure mask based on the percentage of the overlap region, and modifying the anatomical structure mask to account for the particular ratio of sensitivity to specificity; wherein for the particular ratio of sensitivity to specificity, the sensitivity is defined as a volume of an anatomical structure correctly included in a sampling region divided by a total anatomical structure volume, and the specificity is defined as a volume of a non-anatomical structure correctly excluded from the mask divided by a total non-anatomical structure volume.