1. A method comprising: accepting at least one treatment target pertaining to at least one patient via at least one user interface; determining, based at least partly on a least one tissue sample from the at least one patient, at least one characteristic of a subpopulation identifier, wherein the at least one characteristic includes at least one of a genetic expression parameter, an epigenetic expression parameter, or a demographic parameter; receiving at least one input indicating at least one minimum level of efficacy for at least one treatment agent; identifying at least one defined level of incidence of at least one adverse event, the defined level of incidence associated with the at least one characteristic of a subpopulation identifier; identifying at least one treatment agent and at least one supplemental agent for use in the context of the at least one treatment target and the at least one defined level of incidence, including at least: applying the at least one defined level of incidence and the at least one characteristic of the subpopulation identifier to identify at least one particular clinically relevant study data; identifying a list of treatment agent options based at least partly on the defined level of incidence associated with the at least one characteristic of the subpopulation identifier, the at least one level of efficacy, and the identified at least one particular study data; and identifying a corresponding list of supplemental agent options known to at least one of increase the efficacy or decrease the level of incidence of the at least one treatment agent; and transmitting for display on at least one display device the list of treatment options and the corresponding list of supplemental agent options, the options ranked based at least partly on the level of efficacy and the level of incidence when the at least one treatment agent is administered in conjunction with the at least one supplemental agent and correlating the treatment agent options with corresponding supplemental agent options; and initiating administration of at least a portion of the at least one treatment agent and the at least one supplemental agent to the at least one patient.