1. A method of determining a physiologic perturbation of a patient, the method comprising: acquiring a video sequence, including a plurality of video frames, of an eye of a patient; selecting at least one parameter of a plurality of parameters including a baseline pupil size, a maximum change in size of a pupil, an average velocity of constriction of the pupil, a maximum velocity of constriction of the pupil, latency of constriction of the pupil, and a velocity of re-dilation of the pupil; determining, using processing circuitry and based on the plurality of video frames, the selected at least one parameter of the plurality of parameters; and determining the physiologic perturbation of the patient based on the determined at least one parameter, wherein the least one parameter of the plurality of parameters is selected based on which physiologic perturbation of the patient is to be determined.