1. A host comprising: a processor; a host memory coupled to said processor; and a host-fabric adapter coupled to said processor and provided to interface with a switched fabric including one or more fabric-attached I/O controllers, the host-fabric adapter including logic for accessing a translation and protection table from said host memory for a data transaction, said translation and protection table including a plurality of translation entries and at least one region entry, said at least one region entry comprising multiple levels of translation entries.