1. A scientist-centric interface system for conducting research using a mass spectrometry instrument with an informatics search tool that utilizes a search algorithm to identify biomolecules such as proteins and peptides, the search algorithm having a set of predefined algorithm control parameters used to control how the idenfication algorithm operates, comprising: a user interface that prompts a user to supply scientist-centric information expressed utilizing terminology of a scientific domain selected from the domains of biology, analytical chemistry or any combination thereof; a translation system receptive of said scientist-centric information and operative to generate control parameters selected from said set of predefined algorithm control parameters; and said translation system having a search algorithm interface whereby said generated control parameters are supplied to said search algorithm to control how the algorithm operates.