1. A method of image registration comprising the steps of: providing at least first image data and second image data; selecting of sub-volumes of the first and the second image data; performing with a processor a registration for each one of the sub-volumes, each registration providing a transformation parameter set; performing with the processor a global registration for the first and second image data, the global registration providing a global transformation parameter set; comparing with the processor one of the transformation parameter sets to other transformation parameter sets and/or to the global transformation parameter set for identification of an outlier transformation parameter set of the transformation parameter sets; performing a registration of the outlier transformation parameter set; and outputting of a signal being indicative of the sub-volume of the outlier transformation parameter set.