1. A computer program product for managing isolation requirements of a multi-node workload application, the computer program product comprising: one or more computer readable storage media and program instructions stored on the one or more computer readable storage media, the program instructions comprising: program instructions to determine one or more first isolation levels for each of a plurality of workload nodes; program instructions to receive performance data for the plurality of workload nodes; program instructions to analyze the performance data for statistical trends in the performance data; program instructions to identify an adverse trend in the statistical trends of the performance data, wherein the performance data represents a plurality of performance metrics and the adverse trend is in a first performance metric of the plurality of performance metrics that describes a first performance characteristic of the plurality of workload nodes; program instructions to analyze a second performance metric of the plurality of performance metrics, wherein the second performance metric describes a second performance characteristic of the plurality of workload nodes; program instructions to, in response to determining that the second performance metric began to deteriorate contemporaneously with the adverse trend in the first performance metric, determine that the deterioration of the second performance metric is a root cause of the adverse trend in the performance data; and program instructions to identify one or more second isolation levels required to meet performance targets, the second isolation levels including an adjustment to the first isolation levels for the plurality of workload nodes.