1. A method for the spatially resolved determination of tissues states of a tissue section, comprising: (a) acquiring a plurality of spatially resolved mass spectra of the tissue section or parts of the tissue section; (b) selecting at least two mass images from the plurality of spatially resolved mass spectra, the selected mass images comprising the mass signals of predetermined mass intervals; (c) smoothing the selected mass images using a smoothing algorithm with smoothing parameters; and (d) calculating a status image from the smoothed mass images using a classification algorithm derived from mathematical statistics.