1. A method for detecting anatomical abnormalities in a body part, the body part including (i) an imaged tissue region captured in a medical image by a medical imaging process, and (ii) a non-imaged tissue region not captured in the medical image by the medical imaging process, the non-imaged tissue region of the body part adjacently outlying the imaged tissue region of the body part with respect to the medical imaging process, the method being implemented by a computing device comprising at least one processor and memory, comprising: receiving, by the computing device, the medical image; and processing, by the computing device, the medical image to identify likely anatomical abnormalities centered in the non-imaged tissue region of the body part, wherein said processing the medical image comprises: defining a first image array that includes both (i) the medical image and (ii) an extended region adjacently outlying the medical image, the extended region being spatially representative of the non-imaged tissue region, the extended region being devoid of image information captured in the medical imaging process; and processing the first image array according to a computer-aided detection (CAD) algorithm, including computing at least one neighborhood-based CAD feature for at least one location in said extended region.