1. A ventilator system comprising: a pressure generating system adapted to generate a volume of breathing gas; a ventilation tubing system including a patient interface for connecting the pressure generating system to a patient; at least one sensor operatively coupled to at least one of the pressure generating system and the ventilation tubing system; a ventilator self-test, the ventilator self-test configured to: consecutively deliver a plurality of substantially equal volume amounts into a closed ventilator circuit; and consecutively release a plurality of substantially equal volume amounts from the closed ventilator circuit; a loss effect compensation module, the loss effect compensation module configured to: receive a pressure measurement for each volume delivery and each volume release from the ventilator self-test; calculate a change in pressure for each volume delivery and each volume release; fit the calculated change in pressure data for each volume delivery and each volume release to an inhalation non-linear tubing compliance model equation and an exhalation non-linear tubing compliance model equation, respectively; derive one or more inhalation tubing compliance compensation coefficients from the inhalation non-linear tubing compliance model equation; and derive one or more exhalation tubing compliance compensation coefficients from the exhalation non-linear tubing compliance model equation; and a processor in communication with and controlling the pressure generating system, the at least one sensor, the ventilator self-test, and the loss effect compensation module.