1. A computer implemented method of segmenting a physiological image comprising: receiving extrinsic data defining extrinsic regions; receiving multiple sets of intrinsic data defining at least one intrinsic region, each intrinsic region corresponding to one extrinsic region and said multiple sets of intrinsic data being obtained from one or more sources; and modifying a shape and size of at least one extrinsic region having a corresponding intrinsic region based on a shape and size of the corresponding intrinsic region, to form a modified extrinsic data; segmenting the physiological image into segmented regions based on the modified extrinsic data, each segmented region which has a corresponding intrinsic region representing a modification based on the corresponding intrinsic region; receiving intrinsic tract data comprising tracts; receiving waypoint regions; identifying a bundle comprising an identified subset of the tracts; and updating the modified extrinsic data with tract data indicative of said bundle.