1. A method of configuring system memory of a computer system, the computer system having at least one input/output (I/O) adapter attached thereto, the at least one I/O adapter capable of providing a plurality of physical functions to the computer system, the method comprising: assigning a memory region of the system memory to the at least one I/O adapter, the memory region being sub-divided into a plurality of sub-memory regions; associating each physical function being provided by the at least one I/O adapter to the computer system with a sub-memory region; and in response to detecting that an I/O error occurs, determining in which of the plurality of sub-memory regions the I/O error is located to isolate the physical function with which the sub-memory region is associated.