1. A method performed by a processor for comparative image analysis, the method comprising: receiving by the processor data representing two or more three dimensional images representing different imaging volumes; registering two or more three-dimensional images using the processor; automatically generating a change map comprising differences between the two or more three-dimensional images using the processor; automatically detecting anomalies in at least one of the two or more three-dimensional images based on the change map using the processor; and displaying the anomalies using a display device.