1. A method for providing planning and dispensation of research and/or treatment for brain disease, comprising: generating radiological information in a region of interest in an area of the a brain of an individual using a radiological imaging system, the region of interest comprising a pathological lesion associated with the brain disease and an area outside the pathological lesion; constructing, using a computer, a physiological states model which assesses physiological states of the region of interest; obtaining, using the computer, locations of sources of interstitial fluid flow, fluid conductivities of paths, and anatomical information in the region of interest using the radiological imaging information; computing, using the computer, velocities of the interstitial fluid flow in the region of interest using the physiological states model, the locations of sources of interstitial flow, the fluid conductivities, and the anatomic information, wherein said computing takes into account changes in interstitial fluid flow caused by the pathological lesion; creating, using the computer, a model of the area of the brain including the region of interest, wherein said model shows the computed velocities of the interstitial flow and interstitial pressure variations in the interstitial fluid changed due to the pathological lesion, within and outside the lesion in the region of interest; and displaying the model for the planning and the dispensation of research and/or treatment for brain disease.