1. A thermostat comprising: a communication port configured to interface with a climate-control system of a building; and a controller configured to establish, via the communication port, at least one control setpoint of the climate-control system, the control setpoint associated with at least one of temperature, humidity, and ventilation of a controlled space in the building, the controller establishing the control setpoint for an activity state of at least one occupant in the building, the control setpoint determined from biofeedback data associated with the occupant.