1. A method for providing an assessment for disease status of a disease in which each step of the method is performed on a computer, comprising the steps of: a) constructing a computational, three-dimensional model of an organ representative of said disease status of a disease based on data for the organ, wherein the organ data includes image data of the organ, and the three-dimensional model includes a fluid-structure interaction and multiple components of the organ; b) computationally obtaining a certain mechanical distribution using the three-dimensional organ model; and c) computationally applying quantitative analysis of the mechanical distribution to provide a quantitative assessment for disease status of a disease, including providing a mechanical biological index that quantifies a degree of the disease status and identifies vulnerability of a plaque to rupture, vulnerability to rupture being based on histopathological plaque classifications.