1. A system of optimizing throughput of tracked assets as work-in-progress (WIP) within a monitored environment, comprising: a plurality of assets; a tag transmitter associated with each asset and operative for transmitting a wireless RF signal that includes data relating to the identification of the asset to which the tag transmitter is associated; and a real time location system (RTLS) infrastructure for tracking the location of the plurality of assets through various containment, staging and processing task areas within the monitored environment as WIP, and including a processor operative with the RTLS infrastructure for determining an asset input rate into WIP at an origin to the WIP for optimizing asset flow rate as WIP through different containment, staging and processing areas within the monitored environment.