1. A method of image registration comprising the steps of: providing at least first image data and second image data, selecting of sub-volumes of the first and the second image data, performing a registration for each one of the sub-volumes, each registration providing a transformation parameter set, performing a global registration for the first and second image data, the global registration providing a global transformation parameter set, comparing one of the transformation parameter sets to other transformation parameter sets and/or to the global transformation parameter set for identification of an outlier transformation parameter set of the transformation parameter sets, outputting of a signal being indicative of the sub-volume of the outlier transformation parameter set.