1. A platform adapted to provide electrical stimulation to a heart and to receive a feedback data set via physiologic instrumentation coupled to the device and adapted to couple to a subject, said platform comprising: a controller comprising a general purpose digital processor and a digital memory, wherein the controller operatively provides a first electrical stimulation therapy to a heart as a function of a feedback data set from physiologic instrumentation adapted to couple to a subject; and an interface electrically coupling the controller to the physiologic instrumentation; wherein the digital memory comprises software instructions executable by the general-purpose digital processor to receive the feedback data set from the interface and to process the feedback data set using a modeling algorithm to modify the electrical stimulation therapy parameters.