1. A fluid delivery system, comprising: a pressurizing device for delivering injection fluid under pressure; a low pressure fluid delivery system; and a pressure isolation mechanism comprising: a first lumen associated with the pressurizing device, a second lumen associated with the low pressure fluid delivery system, and a pressure isolation port; a first valve having a normally open position permitting fluid communication between the first lumen and the second lumen and movable to a closed position when fluid pressure in the first lumen reaches a predetermined pressure level, the first valve isolating the pressure isolation port from the first lumen in the closed position; and a second valve associated with the second lumen and regulating fluid flow through the second lumen.