1. A method of predicting a result of genetic mutation, comprising: determining differences between (i) values of a first plurality of features, of amino acids encoded by a variant of a wild-type polynucleotide sequence, and (ii) values of a second plurality of features, of amino acids encoded by the wild-type polynucleotide sequence; wherein the features of the first plurality are the same as the features of the second plurality; and by a processor and based on the differences, determining a predicted phenotype severity of the variant.