1. An imaging system configured to generate an image of a region of interest (ROI), the imaging system comprising: a source configured to generate a beam; one or more detectors; and a processor in communication with the source and the one or more detectors, the processor configured to: control at least one of the source or the one or more detectors in order to generate ROI data corresponding to the ROI, the ROI data comprising erroneous data based on one or more defects in the one or more detectors; and generate an estimated image of the ROI based on ROI data.