1. A method of assaying a cell comprising: a. Receiving a reference database, wherein the reference database comprises cell datasets produced from characteristic data for at least two known cell lines, tissues, or primary cells, b. Wherein the data was obtained by global profiling, c. Wherein the data was associated with one or more labeled associated biological classes of the cells, d. Receiving a test dataset, wherein the test dataset comprises data produced for an unknown cell line, tissue, or primary cell, e. Wherein the test dataset was obtained by a similar global profiling as for the reference database, f. merging the test dataset into the database producing an updated reference database, g. performing unsupervised classification of the updated reference database producing a computed label classification of the cells in the test dataset.