1 ) A process (IMIERP process) for modifying the features of electrophysiological activity in response to a stimulus, in the brain of a subject, by interactively applying a brain-wave-state modifying stimulus, said process including the steps of: (a) initially monitoring the subjects brain-wave-state; (b) comparing the monitored brain-wave-state with pre-selected modifying criteria associated with a requisite (post-modification) brain-wave-state; (c) applying a brain-wave-state modifying TMS pulse to the subject when the brain wave state substantially meets the pre-selected criteria, otherwise returning to step (a); (d) monitoring the subject's modified brain-wave-state; (e) comparing the monitored brain wave state with pre-selected stimulus-response criteria, associated with a requisite (post-stimulus) response; (f) applying a selected response-stimulus to the subject when the brain wave state substantially meets the pre-selected response criteria;