1. A system for modulating a patient's neurological disease state, the system comprising: one or more sensors that sense at least one signal that comprise a characteristic that is indicative of a neurological disease state; a signal processing assembly in communication with the one or more sensors that processes the at least one signal to estimate the neurological disease state and to generate a therapy to the patient that is based at least in part on the estimated neurological disease state; and a treatment assembly in communication with the signal processing assembly, wherein said treatment assembly delivers the therapy to a nervous system component of the patient.