1. A portable ambulatory infusion system, comprising: a housing; a delivery mechanism at least partially contained within the housing and adapted to facilitate delivery of fluid to a user; a user interface comprising a touchscreen, the touchscreen adapted to display a plurality of input screens and receive touch input from a user on the plurality of input screens; a memory adapted to store operating parameters and settings relating to use of the delivery mechanism; and a processor disposed in the housing and configured to control operation of the portable ambulatory infusion system in an active mode and a safe mode, wherein in the safe mode the processor disables at least one ambulatory infusion system operation that is active in the active mode, the processor further configured to: define one or more active areas on the plurality of input screens configured to receive touch input with selectable icons from the user for the ambulatory infusion system operation; define one or more out of bounds regions associated with corresponding input screens in the memory, wherein the one or more out of bounds regions displayed on the corresponding input screen are defined as areas of the corresponding input screen that are not the one or more active areas associated with the selectable icons configured to receive control input from the user on the corresponding input screen; identify a touch input on the touchscreen on one of the plurality of input screens that is in at least one of the one or more out of bounds regions of the corresponding input screen while the portable ambulatory infusion system operation is in the active mode; suspend the ambulatory infusion system operation in the active mode and place the ambulatory infusion system operation in the safe mode in response to the touch input received in the at least one of the one or more out of bounds regions that are not the one or more active areas associated with the selectable icons, including disabling at least one of the one or more active areas on the corresponding input screen from receiving touch input.