1. Method of making secure the execution of a computer program (EXE) including a set of at least one instruction, which method is characterized in that it includes: a first step (E 30 ), prior to the execution of the computer program, of calculating and storing a first signature (SIG 1 ) representative of the intended execution of the set of instructions, a second step (E 50 ), during the execution of the set of instructions, of calculating and storing a second signature (SIG 2 ) representative of the execution of the set of instructions, and a step (E 60 ) of detecting an anomaly in the execution of the set of instructions on the basis of the first signature (SIG 1 ) and the second signature (SIG 2 ).