1. A method of application program-operating system decoupling comprising: performing, through an application program configured to execute on a client machine, a system call to a first operating system executing on a server machine over an interconnect configured to couple the server machine to the client machine; serving the application program configured to execute on the client machine through the first operating system executing on the server machine in accordance with the system call; wherein the client machine and the server machine are one of standalone computing devices executing a second operating system and the first operating system respectively thereon and virtual machines (VMs) executing instances of the second operating system and the first operating system respectively thereon; and wherein performing the system call to the first operating system executing on the server machine includes: implementing a second operating system proxy layer at the client machine through the second operating system to route a request associated with the system call to the first operating system; implementing a first operating system communication layer at the server machine through the first operating system to interpret the request; and communicating between the second operating system proxy layer and the first operating system communication layer in accordance with the request and the interpretation thereof; and creating a special shell on the client machine such that the application program configured to execute thereon performs the system call to the first operating system instead of the second operating system; marking one of the special shell and the application program executable on the client machine with a loader flag through the second operating system to indicate the system call routing to the first operating system; and intercepting the system call through the second operating system proxy layer early on based on the marked one of the special shell and the application program.