1. A method, comprising: a) providing a chromosome conformation capture (3C) library constructed from cross-linked interacting chromatin segments derived from at least one cell, wherein said 3C library comprises a plurality of ligation products representative of interacting genomic loci, wherein each of said plurality of ligation products is formed by two adjacent restriction fragments; b) annealing unique primer pairs to said plurality of ligation products; and c) ligating said annealed unique primer pairs together, thereby providing a carbon copy chromosome capture (5C) library.