1. A method optimizing an association of a request for communication with at least one respective member of a set of targets, each member of the set of targets having an associated cost of association, and the association having a utility, comprising: determining at least one characteristic of the request for communication; retrieving a profile representing at least one characteristic of a respective member of the set of targets, for a plurality of respective members of a set of targets available to be associated with the request for communication; determining, with at least one automated processor, a predicted cost-utility value of a predicted change in respective profiles of the plurality of respective members of the set of targets available to be associated with the request for communication as a result of a prospective association with the request for communication; determining, with the at least one automated processor, a predicted cost-utility value for the prospective association of the request for communication with respective different subsets of the plurality of respective members of the set of targets available to be associated with the request for communication, dependent on at least the at least one characteristic of the request for communication and the respective profiles of the plurality of respective members of the set of targets available to be associated with the request for communication; determining, with the at least one automated processor, a predicted quantitative relationship of an availability of members of the set of targets available to be associated with the request for communication, and a demand for requests for communication; matching, with the at least one automated processor, the request for communication with a respective subset of the members of a set of targets available to be associated with the request for communication, optimized based on at least: the predicted quantitative relationship of the availability of members of the set of targets available to be associated with the request for communication, and the demand for requests for communication; the determined predicted cost-utility value of the predicted change in the respective profiles of the respective members of the respective subset of the members of a set of targets available to be associated with the request for communication as a result of a prospective matching with the request for communication, and the determined predicted cost-utility value for the prospective matching of the request for communication with the respective different subsets of the members of a set of targets available to be associated with the request for communication as a result of a prospective matching with the request for communication; and configuring a communications network selectively dependent on the optimized matching.