1. A method, comprising: identifying a first number of processors in a computer; identifying a second number of interrupt request (IRQ) lines on a hardware acceleration device in the computer and coupled to the processors, the second number greater than or equal to the first number; associating each of the IRQ lines with one of the processors; selecting a given IRQ line for an application thread; identifying a given processor associated with the given IRQ line; initiating execution of the application thread on the given processor; and configuring, using the given IRQ line, a completion queue for the application thread.