1. A system for quantification of a selected attribute of an image volume, said system comprising a processor configured to: receive an image dataset for a volume of interest from at least one imaging modality; perform multi-resolution sampling on the volume of interest; perform real-time three-dimensional (3D) shape-based Gaussian filtering on the dataset, said real-time 3D shape-based Gaussian filtering comprising determining a cylindrical response and a spherical response; process the dataset for a selected attribute to obtain a plurality of responses from the real-time shape-based Gaussian filtering, said processing the dataset for the selected attribute comprising determining a degree of cylindricalness to eliminate vessel-like cylindrical responses from the obtained responses; identify a center of each response of the plurality of responses to provide a plurality of spatial references; assess a volume of each response of the plurality of responses using a respective spatial reference of the plurality of spatial references; and compute a volume index of an aggregate of the plurality of obtained responses based on the assessed volumes, the computed volume index representing a volume of the plurality of obtained responses.