1. A method, comprising: identifying a first number of processors in a computer; identifying a second number of interrupt request (IRQ) lines on a hardware acceleration device in the computer and coupled to the processors, the second number greater than or equal to the first number; associating, using a device driver by a first given one of the processors, each of the IRQ lines with one of the processors; selecting, by the first given processor, a given IRQ line for an application thread; identifying, by the first given processor, a second given one of the processors associated with the given IRQ line; initiating, by the first given processor, execution of the application thread on the second given processor; configuring through the device driver by the first given processor, using the given IRQ line, a completion queue for the application thread; and prior to selecting the given IRQ line, identifying a plurality of event queues on the hardware acceleration device, and associating each of the IRQ lines with one of the event queues by the first given processor; wherein a given one of the event queues is bound to the completion queue prior to the first given processor initiating execution of the application thread on the second given processor; and wherein the second given processor is configured to lock the completion queue upon detecting that the given IRQ line is associated with a third given one of the processors by acquiring a spinlock for the completion queue, setting an processor owner flag to an invalid value, activating a read memory barrier, waiting for an in-use flag to clear, and releasing the spinlock.