1. A compound having the Formula I: 20 R 1 is alkyl, haloalkyl, aminoalkyl, C 1-10 alkylaminoalkyl. di(C 1-10 )alkylaminoalkyl, alkenyl, alkynyl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, cyanoalkyl, alkanoylamidoalkyl, alkanoyloxyalkyl, azidoalkyl, alkenyloxyalkyl, or alkoxyalkyl; R 6 and R 7 are taken together to form a five or six membered carbocyclic or heterocyclic ring; R 5 and R 8 are independently selected from the group consisting of hydrogen, halogen, haloalkyl, aryl, heterocyclic, heteroaryl, alkyl, alkenyl, alkynyl, aralkyl, aralkenyl, aralkynyl, hydroxyalkyl, nitro, amino, cyano, alkanoylamido, hydroxy, thiol, alkanoyloxy, alkoxy, carboxy, carbonylamido and thioalkoxy; X is O or S; and Y is optionally substituted aryl or optionally substituted heteroaryl; with the proviso that when R 6 and R 7 are taken together as —OCH 2 O—, then Y is not 2-thienyl, unsubstituted phenyl or a phenyl group that is substituted with a non-fused substituent; when R 6 and R 7 are taken together as —OCH 2 O— and Y is 3,4-methylenedioxyphenyl, R 1 is not C 1-5 alkyl, C 3-6 cycloalkyl, or C 3-6 cycloalkyl-C 1-3 alkyl; or when R 6 and R 7 are taken together as —OCH 2 CH 2 O—, then Y is not unsubstituted phenyl or a phenyl group that is substituted with a non-fused substituent.