1. A computerized method for determining the impact of a perturbation on a biological system, comprising: receiving, at a processor, a first dataset corresponding to a response of a biological system to a first treatment, wherein the biological system comprises a plurality of biological entities wherein each biological entity in the biological system interacts with at least one other biological entities in the biological system; receiving, at a processor, a second dataset corresponding to a response of the biological system to a second treatment different from the first treatment; providing, at a processor, a plurality of computational network models that represent the biological system, each model including nodes representing a plurality of biological entities and edges representing relationships between the nodes in the model; generating, at a processor, a first set of scores representing the perturbation of the biological system based on the first dataset and the plurality of models, and a second set of scores representing the perturbation of the biological system based on the second dataset and the plurality of computational models; and generating, at a processor, one or more biological impact factor(s) based on each of the first set and second set of scores that represent the biological impact of the perturbation on the biological system.