1. An apparatus for automated, non-invasive evaluation of cell activity, comprising: a hypothesis selection module configured to select a first hypothesis from a plurality of hypotheses characterizing cells as shown in an image, each of the plurality of hypotheses including an inferred characteristic of one or more of the cells based on a mapping of a representation of each of the one or more of the cells to one or more boundary segments associated with each of the one or more of the cells, the hypothesis selection module being configured to determine a characteristic of the one or more of the cells based on the inferred characteristic associated with the first hypothesis; the hypothesis selection module being implemented in at least one of a memory or a processing device.