1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising: A. a sensing-module, configured to sense an input related to affect; B. a signal processor in communication with sensing module and which calculates a neural state; C. a control module-in communication with signal processor and which is configured to generate-a signal which modulates the sympathetic nervous system; D. an output module in communication with said control module; and E. a modulator configured to interface with a portion of the sympathetic nervous system.