1. A communication system, comprising: (a) a communication device, comprising: (1) a digital radio frequency communication system configured to wirelessly transmit messages comprising first digital data addressed based on targeting information in a first mode of operation, and to wirelessly receive messages comprising second digital data in a second mode of operation; (2) an automated processor, configured to: (i) receive the first digital data and targeting information in the first mode of operation, control the digital radio frequency communication system to establish a first communication session with a target corresponding to the targeting information, and to transmit the first digital data to the target; and (ii) control the digital radio frequency communication system in a second mode of operation to establish a second communication session with a source, and to receive second digital data from the source; and (b) a computer readable medium, configured to store therein computer executable program instructions, which cause an automated programmable device to: (1) generate a user interface for interaction with a human user; (2) control communication of the first digital data to the communication device; (3) define the transmission targeting information, having at least one mode of operation in which the transmission targeting information is derived by a user selection, through the generated user interface, of an entry from an address book containing at least telephone numbers, and in which a human editable label comprises the transmission targeting information communicated to the communication device; and (4) present the second digital data received from the communication device to the human user.