1. A method of processing a plurality of medical billing claims stored in a queue by defining at least one cluster comprising a subset of the plurality of medical billing claims, the method comprising acts of: grouping, using at least one processor, each of the plurality of medical billing claims into the at least one cluster based on at least one predetermined cluster pattern that includes at least one attribute; validating the at least one cluster using predetermined criteria to determine if the at least one cluster should be analyzed, discarded, and/or marked for further analysis; collecting information, based on the at least one predetermined cluster pattern, about each of the medical billing claims in the at least one cluster; and determining a root cause issue for the plurality of medical billing claims in the at least one cluster based on the collected information.