1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising: A. a signal conditioning circuit; B. a sensor array in communication with said signal conditioning circuit; C. a signal processor in communication with said signal conditioning circuit, wherein said signal processor performs neural state estimation; D. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state; E. an output stage circuit in communication with said control circuit; and F. a stimulating electrode array, in communication with said output stage circuit, said stimulating electrode array configured to be in communication with a component of the sympathetic nervous system.