1. A method for automated, non-invasive evaluation of cell activity in human embryos, oocytes, or pluripotent cells to determine a developmental potential with an imaging system, the method comprising: acquiring a series of time-sequential images of the cells in a multi-well culture dish with a camera of at least one time-lapse microscope of the imaging system; selecting an image from the series of time-sequential images, wherein the selected image is preceded by a previous image in the series of time-sequential images of the cells; extracting observable geometric information of the cells from the selected image; generating a plurality of first hypotheses characterizing the cells as shown in the image, wherein generating the plurality of first hypotheses comprises: determining an inferred characteristic of one or more of the cells based on a mapping of a representation of each of the one or more of the cells to the observable geometric information associated with the cells; retrieving a plurality of parent hypotheses associated with the previous image in the series of time-sequential images of the cells; generating a plurality of preliminary hypotheses based on the plurality of parent hypotheses; and generating the plurality of first hypotheses based on the plurality of preliminary hypotheses and based on the observable geometric information of the cells from the selected image; selecting a first hypothesis from the plurality of first hypotheses associated with the image; and determining a characteristic of the one or more of the cells based on the inferred characteristic associated with the first hypothesis to determine an indicator of developmental potential for the cells.