1. A method for hemodynamic determination in medical imaging, the method comprising: acquiring medical scan data representing a vessel structure of a patient; extracting a set of features from the medical scan data; modifying a first of the features of the set, the modifying representing a change to the vessel structure due to therapy; assigning an uncertainty to the first feature of the set; inputting, by a processor, the features to a machine-trained classifier, the features including the first feature after the modifying and with the uncertainty, the machine trained classifier trained only from synthetic data not specific to any patients; and outputting, by the processor with application of the machine-trained classifier, a hemodynamic metric with a confidence interval for different values of the hemodynamic metric.