title: unable to install R packages depending on rtracklayer R3.4.0
body: <p>I have updated R to R3.4.0 on my mac. Unfortunately now I can't install any bioconductor packages which depends on the <code>rtracklayer</code>.</p>
  
  <p>I have <code>Bioc version 3.5</code> and <code>R version 3.4.0</code>
  I have installed the latest versions of <code>BiocInstaller</code> (v. 1.26.0).
  There are no problems installing package from bioc such as affy, limma or similar. BUT as soon rtracklayer is needed (all annotations packages) I get the follwoing error message:</p>
  
  <pre><code>&gt; biocLite("BSgenome.Rnorvegicus.UCSC.rn5")
  BioC_mirror: https://bioconductor.org
  Using Bioconductor 3.5 (BiocInstaller 1.26.0), R 3.4.0 (2017-04-21).
  Installing package(s) ‘BSgenome.Rnorvegicus.UCSC.rn5’
  installing the source package ‘BSgenome.Rnorvegicus.UCSC.rn5’
  
  trying URL 'https://bioconductor.org/packages/3.5/data/annotation/src/contrib/BSgenome.Rnorvegicus.UCSC.rn5_1.4.0.tar.gz'
  Content type 'application/x-gzip' length 614635033 bytes (586.2 MB)
  ==================================================
  downloaded 586.2 MB
  
  * installing *source* package ‘BSgenome.Rnorvegicus.UCSC.rn5’ ...
  ** R
  ** inst
  ** preparing package for lazy loading
  Error: package or namespace load failed for ‘rtracklayer’ in dyn.load(file, DLLpath = DLLpath, ...):
   unable to load shared object '/Library/Frameworks/R.framework/Versions/3.4/Resources/library/rtracklayer/libs/rtracklayer.so':
    dlopen(/Library/Frameworks/R.framework/Versions/3.4/Resources/library/rtracklayer/libs/rtracklayer.so, 6): Library not loaded: /usr/local/opt/openssl/lib/libssl.1.0.0.dylib
    Referenced from: /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rtracklayer/libs/rtracklayer.so
    Reason: image not found
  Error : package ‘rtracklayer’ could not be loaded
  ERROR: lazy loading failed for package ‘BSgenome.Rnorvegicus.UCSC.rn5’
  * removing ‘/Library/Frameworks/R.framework/Versions/3.4/Resources/library/BSgenome.Rnorvegicus.UCSC.rn5’
  
  The downloaded source packages are in
      ‘/private/var/folders/sh/kwc66sqn4x36cjf9vncy99xm0000gp/T/RtmpX7Ltad/downloaded_packages’
  Warning message:
  In install.packages(pkgs = doing, lib = lib, ...) :
    installation of package ‘BSgenome.Rnorvegicus.UCSC.rn5’ had non-zero exit status
  </code></pre>
  
  <p>I have found in a different post that it might be possible to set the path to the rtracklayer.so using R CMD otool -L path/to/rtrackalyer.so. I have tried it too.</p>
  
  <pre><code>R CMD otool -L /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rtracklayer/libs/rtracklayer.so
  /Library/Frameworks/R.framework/Versions/3.4/Resources/library/rtracklayer/libs/rtracklayer.so:
      rtracklayer.so (compatibility version 0.0.0, current version 0.0.0)
      /usr/lib/libz.1.dylib (compatibility version 1.0.0, current version 1.2.5)
      /usr/local/opt/openssl/lib/libssl.1.0.0.dylib (compatibility version 1.0.0, current version 1.0.0)
      /usr/local/opt/openssl/lib/libcrypto.1.0.0.dylib (compatibility version 1.0.0, current version 1.0.0)
      /Library/Frameworks/R.framework/Versions/3.4/Resources/lib/libR.dylib (compatibility version 3.4.0, current version 3.4.0)
      /System/Library/Frameworks/CoreFoundation.framework/Versions/A/CoreFoundation (compatibility version 150.0.0, current version 1259.0.0)
      /usr/lib/libSystem.B.dylib (compatibility version 1.0.0, current version 1226.10.1)
  </code></pre>
  
  <p>but it didn't solve the problem.  </p>
  
  <p>I would appreciate any help in solving the problem.</p>
  
  <p>Thanks</p>
  
  <p>Assa</p>
  
  <pre><code>&gt; R.version
                 _                           
  platform       x86_64-apple-darwin15.6.0   
  arch           x86_64                      
  os             darwin15.6.0                
  system         x86_64, darwin15.6.0        
  status                                     
  major          3                           
  minor          4.0                         
  year           2017                        
  month          04                          
  day            21                          
  svn rev        72570                       
  language       R                           
  version.string R version 3.4.0 (2017-04-21)
  nickname       You Stupid Darkness  
  
  &gt; sessionInfo()
  R version 3.4.0 (2017-04-21)
  Platform: x86_64-apple-darwin15.6.0 (64-bit)
  Running under: OS X El Capitan 10.11.6
  
  Matrix products: default
  BLAS: /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib
  LAPACK: /Library/Frameworks/R.framework/Versions/3.4/Resources/lib/libRlapack.dylib
  
  locale:
  [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
  
  attached base packages:
  [1] stats     graphics  grDevices utils     datasets  methods   base     
  
  other attached packages:
  [1] biomaRt_2.32.0
  
  loaded via a namespace (and not attached):
   [1] Rcpp_0.12.10         IRanges_2.10.0       XML_3.98-1.7         digest_0.6.12       
   [5] bitops_1.0-6         DBI_0.6-1            stats4_3.4.0         RSQLite_1.1-2       
   [9] S4Vectors_0.14.0     tools_3.4.0          Biobase_2.36.0       RCurl_1.95-4.8      
  [13] parallel_3.4.0       compiler_3.4.0       BiocGenerics_0.22.0  AnnotationDbi_1.38.0
  [17] memoise_1.1.0   
  </code></pre>