title: perMANOVA for small sample size
body: <p>I have data of 6 groups with sample size of <code>n = 2, 10, 2, 9, 3, 1</code> and I want to perform Permutational multivariate analysis of variance (PERMANOVA) on these data.</p>
  <p>My question is: Is it correct to run perMANOVA on these data with the small sample size? The results look strange for me because the group of <code>n = 1</code> showed insignificant difference to other groups although the graphical representation of the groups clearly show a difference.</p>
  <p>Thank you</p>