What's the meaning behind S.A.D. and Smiles?


From the Punk Hazard arc, we have learned that Vegapunk had created a unique
substance called [S.A.D.](http://onepiece.wikia.com/wiki/SAD), which is one of
the few things needed to create
[Smiles](http://onepiece.wikia.com/wiki/Artificial_Devil_Fruit#Smiles),
artificial Zoan Devil Fruits.

So basically we have (a joker) using sadness to create smiles. I doubt Oda
named both objects that way accidentally. So does anybody know if Oda has ever
mentioned what the symbolism is behind S.A.D and Smiles?




The substance is just "SAD" not "S.A.D". Considering that Caesar Clown is the
only person in the world who knows how to manufacture it, and he uses it to
create artificial fruits that he calls "smiles", it was just an appropriate
name to fit into the theme. Clown, smiles, sad, etc.

![SAD
vat](https://vignette4.wikia.nocookie.net/onepiece/images/c/c2/SAD_Infobox.png/revision/latest/scale-
to-width-down/250?cb=20130915135855)

