Estimates of hypothetical influenza deaths in the 2010 United States population (308,745,538 persons) across varying values of case-fatality ratio and the cumulative incidence of infection in the population. Selected estimated numbers of deaths are indicated with a black line, across each relevant combination of case-fatality ratio and cumulative incidence. In addition, the background color transitions from blue to yellow to red as the estimated absolute number of deaths increases.  Case-fatality ratio is an example of a clinical severity measure and cumulative incidence of infection is an example of a transmissibility measure in the Pandemic Severity Assessment Framework.
Carrie Reed, Matthew Biggerstaff, Lyn Finelli, Lisa M. Koonin, Denise Beauvais, Amra Uzicanin, Andrew Plummer, Joe Bresee, Stephen C. Redd, and Daniel B. Jernigan
<p>Reed C, Biggerstaff M, Finelli L, Koonin LM, Beauvais D, Uzicanin A, et al. Novel Framework for Assessing Epidemiologic Effects of Influenza Epidemics and Pandemics. Emerg Infect Dis. 2013;19(1):85-91. <a rel="nofollow" class="external free" href="https://dx.doi.org/10.3201/eid1901.120124">https://dx.doi.org/10.3201/eid1901.120124</a>
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