Titanium dioxide (TiO2), an insoluble white powder, is used extensively in many commercial products, including paint, cosmetics, plastics, paper, and food, as an anticaking or whitening agent. It is produced and used in the workplace in varying particle-size fractions, including fine and ultrafine sizes. The number of U.S. workers currently exposed to TiO2 dust is unknown.
<p>This NIOSH CIB, based on our assessment of the current available scientific information about this widely used material, (1) reviews the animal and human data relevant to assessing the carcinogenicity and other adverse health effects of TiO2, (2) provides a quantitative risk assessment using dose-response information from the rat and human lung dosimetry modeling and recommended occupational exposure limits for fine and ultrafine (including engineered nanoscale) TiO2, and (3) describes exposure monitoring techniques, exposure control strategies, and research needs. This report only addresses occupational exposures by inhalation, and conclusions derived here should not be inferred to pertain to nonoccupational exposures.
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DHHS (NIOSH) Publication Number 2011-160
U.S. <a href="https://en.wikipedia.org/wiki/National_Institute_for_Occupational_Safety_and_Health" class="extiw" title="w:National Institute for Occupational Safety and Health">National Institute for Occupational Safety and Health</a>
2011-04
<a rel="nofollow" class="external free" href="https://www.cdc.gov/niosh/docs/2011-160/">https://www.cdc.gov/niosh/docs/2011-160/</a>