It is assumed that the subject of the painting may not be the obvious one of card players, but may in fact refer to a secret political alliance at the highest level. In this case the figure on the left would be Emperor Charles V and on the right Cardinal Wolsey, and both would be entering into a secret agreement between Spain and England against Francis I of France. The woman in the centre would be Margaret of Austria, sister of Charles V and regent of the Netherlands.
<bdi><a href="https://en.wikipedia.org/wiki/en:Lucas_van_Leyden" class="extiw" title="w:en:Lucas van Leyden"><span title="artist, painter (1494-1533)">Lucas van Leyden</span></a>
</bdi>
1525 <a href="https://www.wikidata.org/wiki/Q21711541#P571" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="https://upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" style="vertical-align: text-top" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20"></a>
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