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<p>Recombinant Human Platelet-Derived Growth Factor-ββ (rhPDGF-ββ)<br>LT Vinh T. Ton, DC, USN and Commander Ivan Roman, DC, USN<br><br>Introduction<br>Growth factors are proteins that have the ability to stimulate cell growth, proliferation and differentiation. Discovered in 1974, Platelet Derived Growth Factor (PDGF) is stored in the alpha granules of platelets and also produced by osteoblasts, macrophages and monocytes. Three different isomers of PDGF exist: PDGF-αα, PDGF-ββ, and PDGF-αβ. PDGF-ββ has chemotactic and mitogenic effects on periodontal mesenchymal stem cells, cementoblasts, periodontal ligament (PDL) fibroblasts  and osteoblasts . Because of these properties PDGF-ββ has been investigated as a potential biologic material to aid in periodontal soft and hard tissue regeneration. PDGF can be extracted from the patient by centrifugation of their whole blood to obtain platelet rich plasma (PRP). Activation of the platelets in PRP releases the PDGFs. Procuring PDGF in this manner has limitations. The number of platelets (and consequently PDGF-ββ levels) in PRP varies depending on the procurement method, it is time consuming, additional equipment increases expense, and requires a phlebotomy. Recombinant human PDGF-ββ (rhPDGF-ββ) now commercially available can be produced in unlimited quantities, contains pure and consistent concentrations of the protein, reduces need for additional equipment and does not require a phlebotomy. The purpose of this clinical update is to review the biological properties of rhPDGF-ββ and its possible clinical applications.
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<br>Subjects: Platelet-Derived Growth Facto; Periodontal Ligament; Platelet-Rich Plasma;</div>
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U.S. Navy. Naval Postgraduate Dental School</div>
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