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<p>Biopsy Tissue Submission Guidelines<br>Major Heather Olmo, DC, USA, Lieutenant Commander Laura Carle, DC,USN, Captain Robert D. Foss, DC, USN and Captain Paul Shick, DC, USN<br><br>Introduction<br>In the practice of modern medicine it is imperative that an accurate diagnosis be obtained. A biopsy, which is defined as the removal of tissue from a living body for diagnostic study, is the gold standard and an integral part of the diagnostic process. It is the key tool in establishing a definitive diagnosis through which treatment is guided. It is a critical component of evidence based medicine.<br><br>Biopsies may be either excisional or incisional. Exfoliative cytology, fine needle aspiration and cytobrush technique are adjunctive procedures that may not produce a definitive diagnosis and therefore should not be substituted when a biopsy is indicated. An excisional biopsy is a surgical procedure that re-moves an entire clinically abnormal lesion for histologic examination. It may represent the only treatment rendered or be utilized for complete removal of a previously biopsied lesion. In contrast, an incisional biopsy is a surgical procedure in which only a representative area or areas of a lesion are submitted for microscopic examination. When submitting incisional biopsies the surgeon needs to ensure that the biopsy material is representative of the disease process or lesion. This is accomplished by ensuring that sufficient tissue is submitted and including a margin of clinically normal tissue. Submission of multiple specimens may be necessary for an extensive lesion. Clinical judgment, along with the size and location of the lesion or lesions, usually determines whether an excisional or incisional biopsy is appropriate.
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<br>Subjects: Biopsy; Fine-Needle;  Cytodiagnosis</div>
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U.S. Navy. Naval Postgraduate Dental School</div>
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