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<p>Epidemiology and Prevention of Acute Respiratory Disease in Navy Recruits<br>ANNUAL PROGRESS REPORT<br>by<br>ROBERT O. PECKINPAUGH, CAPTAIN MC USN<br>NOVEMBER 1970<br>Washington, D. C. 20315<br>Annual Report to the Commission on Influenza<br>of the Armed Forces Epidemiological Board<br>Navy Research Project Nos: MF 12.524.009-4013B; M4305.12-4001B<br><br>Surveillance studies<br>Recruit hospital admission rates for acute respiratory disease (ARD) at NTC,<br>Great Lakes remained low during 1969-70 despite the high incidence of adenovirus type 4 infections. Increased ARD rates at NTC, Orlando were noted during this time and were associated with adenovirus infections. Rubella surveys at Great Lakes indicated that only 9% of incoming recruits were without pre-existing antibody. Seventy percent of these susceptibles became infected, but most were not hospitalized. An increase in rubella infections at Orlando was noted. A 5-year study of various microbial infections at Great Lakes shewed that some recruits experienced no infections while others had multiple infections. Combinations of adenovirus and  meningocaecal infections occurred more frequently than would be expected by chance. <br><br>Influenza studies<br>A2 influenza infections occurred late 1969 and early 1970 (35%   seroconversions) without concomitant increase in ARD rates . Protection studies with aqueous and adjuvant hemagglutinin vaccines were inconclusive. Other studies on the reactogenicity of various influenza vaccines or methods of administration showed that the fewest local reactions were produced by a hemagglutinin vaccine, prepared by zonal centrifugation, when given IM in a 0 . 5 ml dose. An investigation of rheumatoid factor-like substances in recruit sera showed a correlation between titer increases of RFL with increases of naturally or artificially acquired influenza (A2) antibody .<br></p>
<br>Subjects: Acute Respiratory Disease; Navy recruits; epidemiology; influenza; vaccination; immunization; rubella</div>
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U.S. Naval Medical Research Unit No. 4</div>
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