<p>A simulation shows what the grocery store aisle looks like to someone with age-related macular degeneration (AMD). AMD damages the macula, a small spot near the center of the eye’s light-sensing retina. The macula lets us see objects that are straight ahead — it’s the part of the eye used for sharp, central vision.
NIH researchers  from the National Eye Institute (NEI) profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. The findings, published online April 21, 2020 in Cell Reports, suggest that the epigenome could be targeted as a therapeutic strategy to prevent leading causes of vision loss, such as AMD.
Learn more: &lt;a href="<a rel="nofollow" class="external free" href="https://www.nih.gov/news-events/news-releases/nei-researchers-link-age-related-dna-modifications-susceptibility-eye-disease">https://www.nih.gov/news-events/news-releases/nei-researchers-link-age-related-dna-modifications-susceptibility-eye-disease</a>" rel="noreferrer nofollow"&gt;www.nih.gov/news-events/news-releases/nei-researchers-lin...&lt;/a&gt;
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Credit: National Eye Institute, NIH
<a rel="nofollow" class="external text" href="https://www.flickr.com/people/132318516@N08">NIH Image Gallery</a> from Bethesda, Maryland, USA
<a rel="nofollow" class="external text" href="https://www.flickr.com/photos/nihgov/50337925921/">AMD Simulation</a>