High magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of a <b><a href="https://en.wikipedia.org/wiki/Mallory_body" class="extiw" title="w:Mallory body">Mallory body</a></b>, as seen in <a href="https://en.wikipedia.org/wiki/steatohepatitis" class="extiw" title="w:steatohepatitis">steatohepatitis</a>. <a href="https://en.wikipedia.org/wiki/liver" class="extiw" title="w:liver">Liver</a> <a href="https://en.wikipedia.org/wiki/biopsy" class="extiw" title="w:biopsy">biopsy</a>. <a href="https://en.wikipedia.org/wiki/H%26E_stain" class="extiw" title="w:H&amp;E stain">H&amp;E stain</a>.
<p>Mallory bodies are eosinophilic cytoplasmic inclusions that are aggregates of denatured keratin filaments.  They have a <i>twisted rope-like</i> appearance.  On trichrome stain they are green/dark brown. 
</p><p>Associations (histologic):
</p>
<ul><li>They often have neutrophils around them.</li>
<li>They frequently are seen in hepatocytes undergoing <a href="https://en.wikipedia.org/wiki/ballooning_degeneration" class="extiw" title="w:ballooning degeneration">ballooning degeneration</a>.</li></ul><p>Deutsch: Starke mikroskopische Vergrösserung eines <a href="https://en.wikipedia.org/wiki/Mallory-K%C3%B6rper" class="extiw" title="w:Mallory-Körper">Mallory Körperchens</a>, welches als solches in einer <a href="https://en.wikipedia.org/wiki/Steatohepatitis" class="extiw" title="w:Steatohepatitis">Steatohepatitis</a> verkommt. <a href="https://en.wikipedia.org/wiki/Leber" class="extiw" title="w:Leber">Leber</a><a href="https://en.wikipedia.org/wiki/Biopsie" class="extiw" title="w:Biopsie">biopsie</a>. <a href="https://en.wikipedia.org/wiki/H%26E-F%C3%A4rbung" class="extiw" title="w:H&amp;E-Färbung">Hämatoxylin-Eosin-Färbung</a>.
</p><p>Mallory Körper sind <a href="https://en.wikipedia.org/wiki/Eosin" class="extiw" title="w:Eosin">eosinophile</a>, <a href="https://en.wikipedia.org/wiki/Zytoplasma" class="extiw" title="w:Zytoplasma">zytoplasmatische</a> Einschlüsse, wobei es sich um Aggregate von <a href="https://en.wikipedia.org/wiki/Denaturierung_(Biochemie)" class="extiw" title="w:Denaturierung (Biochemie)">denaturierten</a> <a href="https://en.wikipedia.org/wiki/Keratin" class="extiw" title="w:Keratin">Keratin</a><a href="https://en.wikipedia.org/wiki/Filament" class="extiw" title="w:Filament">filamenten</a> handelt. Sie erscheinen in ihrem Äusseren wie gewundene Stränge. In der trichromatischen Färbung sind sie grün/dunkel braun.
</p>
<h2><span class="mw-headline" id="Prevalence_and_associations">Prevalence and associations</span></h2>
<p>They are classically found in the livers of people suffering from <a href="https://en.wikipedia.org/wiki/alcoholic_liver_disease" class="extiw" title="w:alcoholic liver disease">alcoholic liver disease</a> and were once thought to be specific for that.
</p><p>They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).
</p><p>They are a recognized feature of <a href="https://en.wikipedia.org/wiki/Wilson%27s_disease" class="extiw" title="w:Wilson's disease">Wilson's disease</a> (25%), <a href="https://en.wikipedia.org/wiki/primary_biliary_cirrhosis" class="extiw" title="w:primary biliary cirrhosis">primary biliary cirrhosis</a> (24%), non-alcoholic cirrhosis (24%), <a href="https://en.wikipedia.org/wiki/hepatocellular_carcinoma" class="extiw" title="w:hepatocellular carcinoma">hepatocellular carcinoma</a> (23%) and morbid obesity (8%), among other conditions.
</p>
<h2><span class="mw-headline" id="See_also">See also</span></h2>
<ul><li><a href="//commons.wikimedia.org/wiki/File:Mallory_body_high_mag.jpg" title="File:Mallory body high mag.jpg">Image:Mallory body high mag.jpg</a> - uncropped version of this image.</li></ul>
<a href="//commons.wikimedia.org/wiki/User:Nephron" title="User:Nephron">Nephron</a>
CC BY-SA 3.0
<span class="int-own-work" lang="en">Own work</span>