ANGPT1, ANGPT2 and ANGPT4 activate TIE2. Intracellular signal transduction can proceed via DOK-R (yellow arrow) or alternatively via Akt to eNOS (orange arrow).
<a href="//commons.wikimedia.org/wiki/User:Mjeltsch" title="User:Mjeltsch">Mjeltsch</a>
CC BY-SA 4.0
<span class="int-own-work" lang="en">Own work</span>