Minor akathisia-like behavior in mice treated with 3 μg LAC. In comparison to sham mice, LAC-treated mice demonstrate less immobile behavior and increased restlessness in the tail suspension test. Indicated is a representative 1 min interval from the tail suspension test of a LAC-treated mouse (trial period: 2 min 30 s—3 min 30 s), during which the mouse shows minor akathisia-like behavior (periods of continuous movement, combined with intervals of immobility). The video is shown at 4x its normal speed.
Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A
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<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937/bin/Video2.MP4">Supplementary Video 2</a> from <cite style="font-style:normal">Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937">Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein</a>". <i>Frontiers in Behavioral Neuroscience</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3389/fnbeh.2015.00068">10.3389/fnbeh.2015.00068</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25873870">25873870</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937">4379937</a>.</cite>