Simulation Example. This movie shows an example of a simulation with fewer molecules than those simulations used to generate the intensity carpets reported in the paper. Here, 1000 Rac1 molecules are plotted in a cell similar to Fig 4G; wherein, the actin islands increase in affinity from left to right. Each island, from left to right respectively, binds 3.125%, 6.25%, 9.375% and 12.5% of the total Rac1 population. To obtain statistically significant data, we simulate 100,000 Rac1 molecules to generate the intensity carpets reported above.
Lakhani V, Hinde E, Gratton E, Elston T
CC BY 4.0
<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659588/bin/pone.0143753.s007.mov">S1 Movie</a> from <cite style="font-style:normal">Lakhani V, Hinde E, Gratton E, Elston T (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659588">Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands</a>". <i>PLOS ONE</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pone.0143753">10.1371/journal.pone.0143753</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/26606145">26606145</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659588">4659588</a>.</cite>