Inhibition of all three mitotic cyclins maintains ER reorganization in an interphase state. Pdi-GFP (green) H2-RFP (red) were injected with double stranded RNAs targeting all three mitotic cyclins (CycA, CycB, and CycB3) at cycle 8 and imaged during cycle 11. Knockdown of all three mitotic cyclins blocked entry into mitosis and maintained the ER reorganization in an interphase-like state. Frames were taken every 10 seconds. This video corresponds to Fig. 6A. Playback at 10 fps.
Bergman Z, Mclaurin J, Eritano A, Johnson B, Sims A, Riggs B
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<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331435/bin/pone.0117859.s011.mov">S5 Movie</a> from <cite style="font-style:normal">Bergman Z, Mclaurin J, Eritano A, Johnson B, Sims A, Riggs B (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331435">Spatial Reorganization of the Endoplasmic Reticulum during Mitosis Relies on Mitotic Kinase Cyclin A in the Early Drosophila Embryo</a>". <i>PLOS ONE</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pone.0117859">10.1371/journal.pone.0117859</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25689737">25689737</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331435">4331435</a>.</cite>