Tumor survival with high spatial heterogeneity. This movie shows a representative simulation that results in tumor survival in a regime with high spatial heterogeneity. The first M2 macrophage arrives substantially earlier than in either S1 Movie or S3 Movie, resulting increased M2 feedback and ultimately the survival of the tumor. All cells and signals are the same as in S1 Movie (see caption for S1 Movie).
Wells D, Chuang Y, Knapp L, Brockmann D, Kath W, Leonard J
CC BY 4.0
<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028/bin/pcbi.1004181.s014.mp4">S5 Movie</a> from <cite style="font-style:normal">Wells D, Chuang Y, Knapp L, Brockmann D, Kath W, Leonard J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028">Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks</a>". <i>PLOS Computational Biology</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pcbi.1004181">10.1371/journal.pcbi.1004181</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25905470">25905470</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028">4408028</a>.</cite>