Clinical signs of recipient animal with CH1641 scrapie. A clinical examination carried out at 514 days post inoculation reveals a bilaterally absent menace response: the sheep does not blink in response to movement of a hand/finger towards the eye but blinks when the skin surrounding the eye is touched with artery forceps. Hind limb ataxia is present (excessive swaying of the hind limbs and awkward placement of the limbs when it moves in the corner of the corridor). It bumps its head against the corner of one of the food troughs protruding into the corridor when it turns and also moves once with its head very close to the food trough after it walks from the corner towards the camera, which suggests some visual impairment. It is however able to negotiate obstacles placed on the floor of the corridor without difficulty. Camera surveillance of the pen showed abnormal lying down and rising behaviour of this sheep (identifiable by the orange arrow) compared to its pen mates (identifiable by the white circle).
Simmons M, Moore S, Lockey R, Chaplin M, Konold T, Vickery C, Spiropoulos J
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<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339189/bin/pone.0117063.s001.mov">S1 File</a> from <cite style="font-style:normal">Simmons M, Moore S, Lockey R, Chaplin M, Konold T, Vickery C, Spiropoulos J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339189">Phenotype Shift from Atypical Scrapie to CH1641 following Experimental Transmission in Sheep</a>". <i>PLOS ONE</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pone.0117063">10.1371/journal.pone.0117063</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25710519">25710519</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339189">4339189</a>.</cite>