The SUNS mutant M1 significantly suppresses severe locomotor defects in the  C .  elegans  model of ALS expressing SOD1 G85R  in neurons. An SOD1G85R-expressing C. elegans with severe locomotor defects is shown side by side with an isolated suppressor mutant (M1) that exhibits significantly improved movement. The animals were age matched and videotaped as day 1 adults.
Periz G, Lu J, Zhang T, Kankel M, Jablonski A, Kalb R, McCampbell A, Wang J
CC BY 4.0
<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383508/bin/pbio.1002114.s009.mp4">S1 Movie</a> from <cite style="font-style:normal">Periz G, Lu J, Zhang T, Kankel M, Jablonski A, Kalb R, McCampbell A, Wang J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383508">Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription</a>". <i>PLOS Biology</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pbio.1002114">10.1371/journal.pbio.1002114</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25837623">25837623</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383508">4383508</a>.</cite>