“Behavioral despair” in the tail suspension test. After a period of initial struggle, control mice demonstrate intervals of immobile behavior, reflecting reluctance to maintain active escape-oriented behavior. Indicated is a representative 1 min interval from the tail suspension test of a sham-treated mouse (trial period: 2 min 30 s—3min 30 s), during which the mouse shows primarily immobile behavior. The video is shown at 4x its normal speed.
Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A
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<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937/bin/Video1.MP4">Supplementary Video 1</a> from <cite style="font-style:normal">Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937">Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein</a>". <i>Frontiers in Behavioral Neuroscience</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3389/fnbeh.2015.00068">10.3389/fnbeh.2015.00068</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25873870">25873870</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937">4379937</a>.</cite>