PLK1 is required for full activation of the APC/C. Time-lapse imaging of securin-EGFP (green) and H2B-mCherry (red) after DMSO (control, top) or 100 nM BI2536 (bottom) was added at the time of metaphase I (6.5 hours after the induction of meiotic resumption). Time after BI2536 addition (hh:mm). Scale bar = 20 μm.
Solc P, Kitajima T, Yoshida S, Brzakova A, Kaido M, Baran V, Mayer A, Samalova P, Motlik J, Ellenberg J
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<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319955/bin/pone.0116783.s013.mp4">S6 Movie</a> from <cite style="font-style:normal">Solc P, Kitajima T, Yoshida S, Brzakova A, Kaido M, Baran V, Mayer A, Samalova P, Motlik J, Ellenberg J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319955">Multiple Requirements of PLK1 during Mouse Oocyte Maturation</a>". <i>PLOS ONE</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pone.0116783">10.1371/journal.pone.0116783</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25658810">25658810</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319955">4319955</a>.</cite>