Tumor death with high functional heterogeneity low M2 feedback. This movie shows a representative simulation that results in tumor death in a regime with high functional heterogeneity and low secretion of M2S by M2 cells. Although M2 cells appear early in the simulation, with low secretion of M2S, these cells have a minimal effect on the overall state of the TME. In particular, naïve macrophages continue to polarize to M1 cells substantially after the arrival of the first M2 macrophage (which is not the case in S5 Movie and S7 Movie), and the tumor is eventually killed. All cells and signals are the same as in S1 Movie (see caption for S1 Movie).
Wells D, Chuang Y, Knapp L, Brockmann D, Kath W, Leonard J
CC BY 4.0
<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028/bin/pcbi.1004181.s018.mp4">S9 Movie</a> from <cite style="font-style:normal">Wells D, Chuang Y, Knapp L, Brockmann D, Kath W, Leonard J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028">Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks</a>". <i>PLOS Computational Biology</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pcbi.1004181">10.1371/journal.pcbi.1004181</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25905470">25905470</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028">4408028</a>.</cite>