Active Notch signalling, 64 cells,  k o f f H e r 1 / 7 = 1 / 3  min -1 . Oscillating Her1 protein levels for cells displayed on a hexagonal lattice. Dark green corresponds to low Her1 protein levels and light green to high Her1 protein levels. The amplitudes have been normalised to the maximum and minimum of each cell’s amplitude. Initial conditions are random for all cells. Notch signalling is strong enough to override random initial conditions and force neighbouring cell clocks into synchrony. From then on (200 minutes plus) cells oscillate in synchrony throughout.
Jenkins R, Hanisch A, Soza-Ried C, Sahai E, Lewis J
CC BY 4.0
<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654481/bin/pcbi.1004459.s017.avi">S4 Movie</a> from <cite style="font-style:normal">Jenkins R, Hanisch A, Soza-Ried C, Sahai E, Lewis J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654481">Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling</a>". <i>PLOS Computational Biology</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pcbi.1004459">10.1371/journal.pcbi.1004459</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/26588097">26588097</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654481">4654481</a>.</cite>