Tumor survival with high functional heterogeneity. This movie shows a representative simulation that results in tumor survival in a regime with high functional heterogeneity. As in S5 Movie, the presence of cells with high functional heterogeneity ensures the early arrival of M2 macrophages and subsequently increases M2 feedback, which together reinforce the pro-tumor state of the TME and ensure tumor survival. All cells and signals are the same as in S1 Movie (see caption for S1 Movie).
Wells D, Chuang Y, Knapp L, Brockmann D, Kath W, Leonard J
CC BY 4.0
<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028/bin/pcbi.1004181.s016.mp4">S7 Movie</a> from <cite style="font-style:normal">Wells D, Chuang Y, Knapp L, Brockmann D, Kath W, Leonard J (2015). "<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028">Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks</a>". <i>PLOS Computational Biology</i>. <a href="https://en.wikipedia.org/wiki/Digital_object_identifier" class="extiw" title="w:Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pcbi.1004181">10.1371/journal.pcbi.1004181</a>. <a href="https://en.wikipedia.org/wiki/PMID" class="extiw" title="w:PMID">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25905470">25905470</a>. <a href="https://en.wikipedia.org/wiki/PubMed_Central" class="extiw" title="w:PubMed Central">PMC</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408028">4408028</a>.</cite>