<b>New ENU-induced alleles at the Kit locus.</b> (A) Three new point mutations inducing loss-of-function of the KIT protein (Sco1, Sco5 and Whc1) and one potential mutation affecting the regulation of the Kit gene (Sow3). Heterozygous individuals carrying the Sco1, Sco5, Sow3 and Whc1 mutations display white spotting on the belly and a white forehead blaze while homozygotes (-/-) have a white coat color with black eyes.
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Magnol L, Chevallier MC, Nalesso V, Retif S, Fuchs H, Klempt M, Pereira P, Riottot M, Andrzejewski S, Doan BT, Panthier JJ, Puech A, Beloeil JC, de Angelis MH, Herault Y: <b>KIT is required for hepatic function during mouse post-natal development.</b> BMC Dev Biol. 2007 Jul 5;7:81. PMID: 17612398 <a rel="nofollow" class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=17612398">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=17612398</a>