 I mean, they can cause bulk symptoms too. So even if you're not bleeding or having any pain, they can cause bulky symptoms. I have patients not even be able to button up their pants because the tumors get so large. Another severe symptom is infertility. This can happen in a couple different ways. One being that the tumor interferes with implantation. Since it's growing inside the uterus, there's nowhere for the fertilized egg to safely attach itself.