 This was a tough one. Coco Gauff lost a 19-seeded Navarro in a big, big upset. Gauff had been chasing a second major singles title since winning the U.S. Open last year. Earlier, fellow American Madison Keyes struggled to win the deciding third set against Jasmine Paolini of Italy. Keyes ultimately left the court in tears with an injury to her left thigh, defaulting the match. Only four Americans remain in the singles competition after other fan favorites, including Ben Shelton and Frances Tiafoe, were knocked out.