 I mean, they can cause bulk symptoms too. So even if you're not bleeding or having any pain, they can cause bulky symptoms. Patients not even be able to button up their pants because the tumors get so large. Another severe symptom is infertility. This can happen in a couple different ways. One being that the tumor interferes with implantation. Since it's growing inside the uterus, there's nowhere for the fertilized egg to safely attach itself.