abstract: UNASSIGNED: 102 Background: After a diagnosis of @entity0 , it can be difficult for @entity1 to understand the role their primary care physician (PCP) should play in their follow up care. METHODS: 65 @entity1 (mean age 60 years, SD = 10) with @entity0 (stage 0-III) were seen by a nurse practitioner for a 60-90 minute consultative survivorship visit and received a treatment summary and personalized survivorship care plan (SCP) utilizing Carevive Care Planning Systems software. The Carevive system incorporates @entity1 -reported and clinical data to create tailored care plans with personalized recommendations for follow up care and supportive referrals, including direction to follow up with primary care for specific care and health maintenance activities. Approximately 6 weeks following their survivorship care visit, @entity1 completed a survey assessing their use of and satisfaction with the SCP. @entity1 were advised that the SCP would be mailed to their referring oncologist and primary care physician. RESULTS: Out of 65 sent, 35 surveys have been completed to date. Survivors were diagnosed approximately 10 months prior, and all were within 6 months following completion of treatment. All @entity1 (100%) reported that they read, or planned to read, their survivorship care plan packet carefully. While all care plans included a recommendation to follow up with their PCP, only (71%) of survivors remembered receiving this recommendation. Of those who did, most (74%) had either seen or scheduled an appointment with their PCP. @entity1 who reported higher @entity3 at the time of the survivorship visit were more likely to report that the follow up care plan helped them take action about seeing their PCP (p = .03). CONCLUSIONS: Coordination between primary and oncology care providers has previously been shown to improve the quality of care for @entity2 survivors. SCPs that emphasize the importance of and activities to be undertaken in primary care may help to improve this coordination. Continuation of this research will help to better understand how to integrate the primary care physician into @entity2 follow up care. Updated data will be shared at time of presentation.

title: Integrating the primary care physician into XXXX follow-up.

answer: @entity2


abstract: The aim of this study was to assess protein overexpression and gene copy number alterations of MET in @entity2 , and to assess its potential as a novel therapeutic target. Ninety cases of clear-cell @entity5 were analyzed for MET protein overexpression and copy number alterations of the MET gene by immunohistochemistry and brightfield double in situ hybridization, respectively. In addition, 101 cases of the @entity2 at advanced stages were also evaluated for comparison. MET overexpression was assigned when complete membrane staining with moderate or strong intensity was observed in at least 10% of the @entity1 cells examined. Double in situ hybridization was determined as positive when the @entity1 exhibited high-level polysomy (>= 4 copies in >= 40% of @entity1 cells) or @entity3 . MET overexpression was detected in 20 of 90 clear-cell @entity5 (22%) and none of 111 @entity2 . Double in situ hybridization was positive in 21 of 89 informative clear-cell @entity5 (24%) and only 3 @entity2 (3%). In the whole population, true amplification of the MET gene was detected only in the clear-cell @entity5 histology (five cases, 6%). In clear-cell @entity5 , double in situ hybridization positivity was highly correlated with the presence of MET overexpression and a poorly differentiated histology of @entity1 (P=0.0105 and 0.00038, respectively). For the @entity0 with clear-cell @entity5 , MET overexpression, as well as advanced clinical stage and the poorly differentiated histology of @entity1 , was identified as an independent unfavorable prognostic factor for overall survival. In conclusion, among @entity2 , the amplification of the MET proto-oncogene is highly selective and commonly occurs in clear-cell @entity5 . MET could serve as a biomarker for the prognostication of @entity0 with clear-cell @entity5 and @entity1 progression, and has potential as a novel therapeutic target for this @entity4 .

title: Gene amplification and protein overexpression of MET are common events in XXXX : their roles in @entity1 progression and prognostication of the @entity0 .

answer: @entity2


abstract: OBJECTIVE: To evaluate the efficacy of a programme of group education for @entity1 , which succeeded in reducing base glucaemia, body mass index and glycosylated haemoglobin, stimulating insulin-treated @entity0 ' self-monitoring of glucaemia, improving their understanding of the disease, and bringing into group education 75% of the target population. DESIGN: A controlled clinical trial with paired samples, lasting two years. SETTING: "Las Fuentes Norte" Health Centre, Zaragoza. @entity0 : 243 type-2 @entity1 , distributed at random, with 120 in the intervention group and 123 in the control group. All @entity0 with no history of group education in the previous two years and with no restrictions on their attending talks and monitoring were included. No-one gave up in the first year; 9 did in the second year. INTERVENTION: Group health education workshop for two days in the first and second years. MEASUREMENTS AND MAIN RESULTS: In the intervention group, at the end of the study, success in the survey increased by 4.2; base glucaemia dropped by 17.1 mg/dl, glycate haemoglobin went down by 0.5, and self-analysis went up by 14.2%, all with significant differences (p < 0.005 and CI 95%). The body mass index went down by 0.3 without significant differences. Knowledge was lost between the first and second year, with worse metabolic control. In the control group there were no significant differences in any variable. CONCLUSIONS: A stable programme of group education may be effective, especially because of the increase in knowledge of the disease, fostering excellent conditions for a change to a healthier life-style.

title: [The education of type-2 XXXX : why not in groups?].

answer: @entity1


abstract: Surgical resection is thought to be the best treatment for @entity3 , including @entity4 and metastatic @entity3 if there are a small number of @entity1 . @entity3 is one of the main causes of @entity5 from @entity1 worldwide. The prognosis of @entity3 is still poor. Mutation of @entity6 , which is well known as a @entity1 suppressor gene, is observed in many cases of advanced @entity3 . @entity1 gene therapy using @entity6 , which transduces the wild-type @entity6 gene in the @entity1 , is a promising new strategy for treating @entity3 . Selective and less invasive gene delivery to the @entity3 is necessary for clinical @entity3 gene therapy. The first purpose of the current study was to determine the best way to deliver the gene of interest to the @entity3 selectively. The second purpose was to study the @entity1 suppressive effect of intrahepatic arterial injection of an adenovirus vector with the @entity6 gene (AdCMV- @entity6 ), followed by administration of CDDP and noting its side effects. We injected AdCMV-LacZ via hepatic arteries of @entity2 bearing RCN-9 colon @entity1 @entity0 in the liver. Injection via the hepatic artery resulted in more successful gene transduction to the @entity3 in a @entity1 -selective manner than did injection via the portal vein. At 48 hrs after arterial injection of AdCMV- @entity6 , CDDP (3 mg/kg) was administered in the peritoneal cavity of each @entity2 . The use of CDDP with arterial injection of AdCMV- @entity6 resulted in more extensive apoptosis in the @entity2 @entity3 without any deterioration in liver function. In conclusion, hepatic arterial injection of an adenovirus vector is better than portal vein injection for gene transduction efficiency, and causes no liver function disorder even when the injection is combined with CDDP.

title: Safety and growth suppressive effect of intra-hepatic arterial injection of AdCMV- XXXX combined with CDDP to @entity2 liver @entity0 .

answer: @entity6


abstract: OBJECTIVE: To evaluate the effects of @entity3 on the formation of adhesions and anastomotic healing in the left colon of @entity0 . METHODS: We divided 40 @entity0 into two groups of 20 animals, administration of @entity3 (study group-E) or saline (control group-C). Each group was divided into subgroups containing 10 animals each for euthanasia in the third (C3 and E3) or the seventh (E7 and C7) postoperative days. The @entity0 were submitted to section of the left colon and end-to-end @entity1 . On the day of reoperation, we evaluated the total amount of adhesions and removed a colonic segment containing the @entity1 for histopathological analysis, assessment of rupture strength and @entity2 concentration. RESULTS: There was no difference between groups in relation to clinical outcome. Two animals in the study group had blocked anastomotic leakage. The animals that received @entity3 had the number of intracavitary adhesions and adhesions to the @entity1 similar to the control group. The anastomoses from the group E3 animals showed lower resistance to rupture the one from the C3 group (p = 0.04). This effect did not occur on the seventh postoperative day (p = 0.37). There was no significant difference between groups in relation to histopathology and @entity2 concentration in the anastomoses. CONCLUSION: The use of @entity3 was associated with decreased tensile strength of left colon @entity1 in @entity0 in the third postoperative day.

title: Effects of XXXX on the healing of left colon anastomoses of @entity0 .

answer: @entity3


abstract: BACKGROUND: The objective was to evaluate the diagnostic accuracy of ultrasmall superparamagnetic @entity4 (USPIO)-enhanced magnetic resonance imaging (MRI) compared to plain MRI in @entity0 with a clinical N+ neck using histology as a gold standard. MATERIALS AND METHODS: Twenty-eight @entity0 underwent unenhanced and USPIO-enhanced MRI using T1-weighted spin echo (SE) sequences and high resolution Turbo-Spin-Echo (TSE) T2-weighted sequences, as well as T2-weighted Gradient Echo (GE) sequences in axial and sagittal slice orientation. The signal intensity (SI) decrease was measured by a region of interest evaluation and visual analysis was performed. RESULTS: Histopathological evaluation of 363 lymph nodes revealed 34 as metastatic. USPIO MRI detected 28 @entity1 (sensitivity 82.3%) and 329 non-metastatic lymph nodes (specificity 100%). Regarding lymph node size, USPIO MRI was correct in all @entity0 who underwent surgery. One lymph node with microinfiltration of @entity2 cells was detected by USPIO MRI. CONCLUSION: There were no side-effects during or after application of the contrast agent. This study confirms the efficacy of MRI with USPIO in @entity0 with @entity3 . USPIO-enhanced MRI could have an important effect on surgery planning. Because of its high specificity, USPIO-enhanced MRI seems to be a diagnostic modality able to differentiate borderline-sized lymph nodes.

title: The efficacy of MRI with ultrasmall superparamagnetic XXXX particles (USPIO) in @entity3 .

answer: @entity4


abstract: @entity4 ( @entity4 ) is a chemokine involved in the macrophage infiltration of @entity1 tissue. Tumor associated macrophages (TAMs) are a population of mononuclear-phagocytic cells, which can express complex functions related to @entity1 biology. The present study was designed to analyse the expression of @entity4 in parenchymal and stromal elements on frozen sections of 27 @entity5 not otherwise specified (NOS) by immunohistochemistry. The expression of @entity4 in @entity1 parenchyma and the degree of @entity1 differentiation were assessed. @entity4 was detected in the @entity3 . Positive immunoreactivity manifested as diffuse, homogeneous, moderate or strong, cytoplasmic staining, confined to @entity1 epithelium. Generally, @entity4 -negative @entity1 tended to be well differentiated, while chemokine-positive @entity1 exhibited a low level of differentiation. @entity4 immunoreactivity was also present in TAMs ( @entity2 positive cells) in 23 of 27 @entity1 , and in endothelial cells in 11 of 27 @entity1 . These results indicate that parenchymal and, more variably, stromal elements of @entity0 invasive @entity3 NOS can express @entity4 in vivo. Additionally, these findings suggest that @entity4 expression in @entity1 parenchyma is correlated with the histological grade of @entity5 .

title: Expression of @entity4 in XXXX invasive ductal breast cancer.

answer: @entity0


abstract: PURPOSE: The oligometastatic state is an intermediate state between a malignancy that can be completely eradicated with conventional modalities and one in which a palliative approach is undertaken. Clinically, high rates of @entity2 control are possible with stereotactic ablative radiation therapy (SABR), using precisely targeted, high-dose, low-fraction radiation therapy. However, in @entity6 , virtually all @entity0 develop progression systemically at sites not initially treated with ablative radiation therapy that cannot be managed with conventional chemotherapy and immunotherapy. We have demonstrated in @entity3 that intravenous administration of @entity8 virus (VSV) expressing defined @entity2 -associated antigens (TAAs) generates systemic immune responses capable of clearing established @entity2 . Therefore, in the  present preclinical study, we tested whether the combination of systemic VSV-mediated antigen delivery and SABR would be effective against @entity4 . METHODS AND MATERIALS: We generated a model of @entity6 in C57BL/6 immunocompetent @entity3 and then used a combination of SABR and systemically administered VSV- @entity7 viral immunotherapy to treat both @entity5 . RESULTS: Our data showed that SABR generates excellent control or cure of local, clinically detectable, and accessible @entity2 through direct cell ablation. Also, the immunotherapeutic activity of systemically administered VSV- @entity7 generated T-cell responses that cleared subclinical @entity1 . We also showed that SABR induced weak T-cell-mediated @entity2 responses, which, particularly if boosted by VSV- @entity7 , might contribute to control of @entity5 . In addition, VSV- @entity7 therapy alone had significant effects on control of both local and @entity1 . CONCLUSIONS: We have shown in the present preliminary @entity3 study using a single @entity2 model that this approach represents an effective, complementary combination therapy model that addresses the need for both systemic and local control in @entity6 .

title: Definitive Management of XXXX in a @entity3 Model Using Combined  Ablative Radiation Therapy and  Viral  Immunotherapy.

answer: @entity6


abstract: To examine the role of protein kinase A (EC 2.7.1.37) isozymes in the @entity3 -induced growth inhibition and neuronal differentiation, we investigated the changes of protein kinase A isozyme patterns in @entity3 -treated SH-SY5Y @entity0 @entity2 cells. @entity3 induced growth inhibition and neuronal differentiation of SH-SY5Y cells in a dose- and time-dependent manner. Neuronal differentiation was evidenced by extensive neurite outgrowth, decrease of @entity4 oncoprotein, and increase of @entity5 mRNA. Type II protein kinase A activity increased by 1.5-fold in differentiated SH-SY5Y cells by @entity3 treatment. The increase of type II protein kinase A was due to the increase of @entity6 have been known to play important role(s) in the growth inhibition and differentiation of @entity1 cells, we further investigated the role of the increased type II protein kinase A by overexpressing @entity6 in SH-SY5Y cells. The growth of @entity6 -overexpressing cells was slower than that of parental cells, being comparable to that of @entity3 -treated cells. @entity3 treatment further increased the @entity6 level and further inhibited the growth of @entity6 -overexpressing cells, showing strong correlation between the level of @entity6 and growth inhibition. However, @entity6 -overexpressing cells did not show any sign of neuronal differentiation and responded to @entity3 in the same way as parental cells. These data suggest that protein kinase A participates in the @entity3 -induced growth inhibition through the up-regulation of @entity6 /type II protein kinase A.

title: Participation of type II protein kinase A in the @entity3 -induced growth inhibition of SH-SY5Y @entity0 XXXX cells.

answer: @entity2


abstract: BACKGROUND: To evaluate hospital costs and reimbursement for open (OAAA) and endovascular (EVAAA) repair of @entity1 . STUDY DESIGN: Review of all @entity0 who underwent OAAA or EVAAA in two teaching hospitals during the period January 1, 2000, to December 31, 2000, was completed for the following: demographics, Diagnosis Related Group (DRG), resource use, length of stay, hospital costs, and reimbursement data. RESULTS: There were 130 @entity1 performed. Fifty-seven (44%) OAAA were completed; EVAAA was attempted in 73 (56%). Seventy EVAAA @entity0 (96%) had endografts placed, and three (4%) required conversion to open repair. Significant differences were noted between OAAA and EVAAA in operative time (311.7 +/- 107.5 minutes versus 263.4 +/- 110.8 minutes, respectively, p = 0.02), ICU admission and length of stay (100%, 5.0 +/- 6.1 days versus 29%, 1.4 +/- 7.1 days, respectively, p = 0.003), and hospital length of stay (12.6 +/- 14.8 days versus 4.9 +/- 13.4 days, respectively, p = 0.002). Total costs were  17,539.00 for EVAAA and  9,042.00 for OAAA. EVAAA was profitable ( 3,072.00) for Medicare DRG 110 classification, but significant loss occurred with DRG 111 ( 5,065.00). Contract renegotiation with private payers (to cover graft costs) was necessary to avoid substantial per- @entity0 loss ( 12,108.00). Overall net per- @entity0 profit for EVAAA was  737.00. CONCLUSIONS: @entity1 repair is significantly more expensive than open repair, with the major portion attributed to graft cost. Although ICU use and total length of stay decreased with EVAAA, overall costs were not substantially reduced. Hospitals must develop new financial strategies and improve the efficiency of their infrastructures in order to offer EVAAA.

title: Hospital costs for endovascular and open repair of XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity3 is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between @entity5 ( @entity5 ) gene polymorphisms and @entity3 risk has attracted widespread attention due to the unique biological functions of FSH. The aim of this study was to further explore the associations between the @entity7 and @entity4 polymorphisms of the @entity5 gene and @entity3 . A case-control study of 212 @entity1 and 164 fertile @entity0 from North China was performed. @entity5 polymorphism genotypes were obtained through direct DNA sequencing. A meta-analysis was also performed. In the single-site association analysis, no significant associations were identified between @entity5 @entity7 and @entity4 polymorphisms and @entity3 (P > 0.05). However, we found that the combined genotypic frequency of Thr/Ala + @entity2 / @entity2 was higher in @entity1 @entity0 than in controls (6.6 vs 1.8%; odds ratio (OR) = 3.795; 95% confidence interval (CI): 1.072-13.434, P = 0.027). In the meta-analysis, there was also no evidence of @entity5 polymorphism ( @entity6 and @entity8 ) association with @entity3 (P > 0.05). However, we found that the combined genotypes Thr/Thr + @entity2 / @entity2 had an increased risk of @entity3 (OR = 1.238; 95%CI: 1.001-1.537, P = 0.049). Our studies further confirmed reports that there were no significant associations between the @entity5 @entity7 and @entity4 polymorphisms and @entity3 risk. However, a combined @entity5 genotype showed significant association with @entity3 .

title: @entity5 gene @entity7 and @entity4 polymorphisms in @entity1 XXXX : an association study in North China and meta-analysis.

answer: @entity0


abstract: OBJECTIVE: To investigate @entity2 (binocular single vision [ @entity5 ] test) and @entity3 (uniocular field of fixation [UFOF] test) characteristics in @entity4 of the orbit and their value in @entity1 management. MATERIAL AND METHODS: @entity0 with isolated @entity4 treated from 2000 to 2010 were included. @entity5 scores were stratified into three categories: low @entity5 category (0-60); moderate @entity5 category (61-80), and high @entity5 category (81-100). UFOF scores were also divided into three categories: low score (60-240), moderate score (241-270), and high score (271-365) categories. RESULTS: A total of 183 @entity0 (106 surgically and 77 conservatively managed) met the inclusion criteria. There was no significant improvement in @entity5 postoperatively in surgically managed @entity0 with preoperatively high @entity5 , whereas there was significant improvement (p  <  0.05) for the high @entity5 category in the conservative group. Preoperative @entity5 was found to be significantly related (p  <  0.05) to postoperative @entity5 , subjective @entity2 outcome, follow-up time, and number of follow-up visits. However, improvement of @entity5 score in the surgical group was not found to be significantly correlated with subjective outcome in relation to @entity2 . Preoperative UFOF score has no influence on subjective outcome in relation to @entity2 . Surgical timing, approach, and choice of implant material were not found to be statistically related to final @entity2 outcome, follow-up time, or number of follow-up visits. CONCLUSIONS: @entity5 is better correlated with @entity2 outcome, follow-up time, and number of follow-up visits than is UFOF. On the basis of this study, surgical intervention would not be recommended for blow-out @entity1 cases with @entity5 score >80% for correction of @entity2 alone.

title: @entity2 and XXXX in orbital @entity4 : 10-year retrospective study.

answer: @entity3


abstract: BACKGROUND: The leaf is an important plant organ, and how it will respond to future global warming is a question that remains unanswered. The effects of experimental warming on leaf photosynthesis and respiration acclimation has been well studied so far, but relatively little information exists on the structural and biochemical responses to warming. However, such information is very important to better understand the plant responses to global warming. Therefore, we grew @entity4 at the three day/night temperatures of 23/18  C (ambient temperature), 25.5/20.5  C (elevated by 2.5  C) and 28/23  C (elevated by 5  C) to simulate the middle and the upper projected warming expected within the 21st century for this purpose. RESULTS: The 28/23  C treatment significantly reduced the life span, total biomass and total weight of seeds compared with the other two temperatures. Among the three temperature regimes, the concentrations of starch, @entity0 , and @entity5 were the lowest at 28/23  C, whereas the total weight of seeds, concentrations of @entity0 and @entity5 , stomatal density (SD), stomatal conductance (gs), net @entity3 assimilation rate (A) and transpiration rate (E) were the highest at 25.5/20.5  C. Furthermore, the number of chloroplasts per cell and mitochondrial size were highest at 25.5/20.5  C and lowest at 28/23  C. CONCLUSIONS: The conditions whereby the temperature was increased by 2.5  C were advantageous for @entity4 . However, a rise of 5  C produced negative effects, suggesting that lower levels of warming may benefit plants, especially those which belong to the same functional group as @entity4 , whereas higher levels of warming may produce negative affects. In addition, the increase in A under moderately warm conditions may be attributed to the increase in SD, @entity0 content, and number of chloroplasts. Furthermore, starch accumulation in chloroplasts may be the main factor influencing chloroplast ultrastructure, and elevated temperature regulates plant respiration by probably affecting mitochondrial size. Finally, high SOD and CAT activities may enable plants grown at elevated temperatures to exhibit relatively high tolerance to temperature stress, thus alleviating the harmful effects of @entity1 anion radicals and @entity2 .

title: The effect of experimental warming on leaf functional traits, leaf structure and leaf biochemistry in XXXX .

answer: @entity4


abstract: The effect of glucagon on renal haemodynamics in @entity1 is controversial. In this study we have examined the effects of perfused glucagon on renal blood flow (RBF) in six conscious @entity1 bilaterally implanted with transit-time ultrasonic flow metering probes around the renal arteries. Glucagon was perfused intravenously over 90 min at doses of 3.12, 6.25, 12.5, 25, 50 and 100 ng kg(-1) min(-1). Mean RBF was calculated over 10 min periods. Blood samples were taken to monitor the time course of the changes in glycaemia and glucagonaemia. The perfusions of glucagon induced rapid and progressive dose-dependent increases in RBF (9-19.2 %, P < 0.05) and glycaemia (29-155 %, P < 0.05) for doses of 25-100 ng kg(-1) min(-1). High positive correlations were found between the increases in RBF and glucagonaemia (R2 = 0.95) and between the increases in RBF and glycaemia (R2 = 0.96). At the lowest doses of glucagon (3.12-12.5 ng kg(-1) min(-1)), the increase in RBF was highly significant; however, the rise in @entity0 level was not. At the highest doses (25-100 ng kg(-1) min(-1)) the time course of the changes in RBF was parallel to that of glucagonaemia throughout the perfusion time. However, between minutes 45 and 90 of the glucagon perfusion, the increase in RBF was the inverse of the change in glycaemia, which decreased. One hour after the end of the 50 and 100 ng kg(-1) min(-1) perfusions, the @entity0 levels were still significantly higher than the baseline, while the RBF values were not. These results are consistent with the idea that the enhanced RBF cannot be attributed to a rise in blood @entity0 level. They also show that the haemodynamic response to glucagon perfusion was more sensitive than the metabolic response. It is concluded that the intravenous perfusion of physiological doses of glucagon induced a highly sensitive dose-dependent increase in RBF in @entity1 .

title: Effects of intravenous perfusion of glucagon on renal blood flow in conscious XXXX .

answer: @entity1


abstract: AIM: To identify differences between defense styles and mechanisms in @entity3 @entity0 with or without @entity1 and their relationship to quality of life. STUDY DESIGN: The study included 37  @entity3 @entity0 with @entity1 (SNP), 36  @entity3 @entity0 without @entity1 and 38  healthy subjects. @entity2 severity was measured using the Visual Analogue Scale (VAS). Psychological condition was assessed using the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI). Defense mechanisms were assessed using a 40-item Defense Style Questionnaire (DSQ-40) and quality of life was assessed using Short Form-36 (SF-36). RESULTS: BDI and BAI scores were significantly higher in the SNP group (p   <   0.001). Idealization and immature defense styles, as well as isolation, displacement and somatization were significantly higher in the SNP group (p   <   0.05). SF-36 parameters also differed significantly between the groups, with controls having the best scores and the SNP group the worst. In linear regression analysis, acting out and BDI were found to affect the @entity2 domain of the SF-36 (p   <   0.001). CONCLUSION: The acting out defensive style and BDI were independently associated with @entity2 -related quality of life. In the SNP group, significant differences were found in the immature and neurotic styles of the defense mechanisms.

title: @entity3 XXXX with @entity1 and its relationship to quality of life.

answer: @entity0


abstract: Magnetic activated @entity0 composite ( @entity6 /AC, MACC) was prepared by a co-precipitation-calcination method. The MACC consisted of porous micro-particle morphology with homogeneously distributed @entity6 and possessed high magnetic saturation moment (8.1emug(-1)). The performance of MACC was evaluated as catalyst and regenerable adsorbent via @entity3 ( @entity4 , @entity5 (  )) activation for @entity1 (MB) removal. Optimum @entity6 /AC w/w ratio was 1:1.5 giving excellent performance and can be reused for at least 3 cycles. The presence of common inorganic ions, namely Cl(-) and @entity2 did not exert significant influence on MB degradation but humic acid decreased the MB degradation rate. As a regenerable adsorbent, negligible difference in regeneration efficiency was observed when a higher @entity5 (  ) dosage was employed but a better efficiency was obtained at a lower MACC loading. The factors hindering complete MACC regeneration are MB adsorption irreversibility and AC surface modification by @entity4 making it less favorable for subsequent MB adsorption. With an additional mild heat treatment (150  C) after regeneration, 82% of the active sites were successfully regenerated. A kinetic model incorporating simultaneous first-order desorption, second-order adsorption and pseudo-first order degradation processes was numerically-solved to describe the rate of regeneration. The regeneration rate increased linearly with increasing @entity5 (  ):MACC ratio. The MACC could potentially serve as a catalyst for @entity4 activation and regenerable adsorbent.

title: Performance of magnetic activated @entity0 composite as XXXX activator and regenerable adsorbent via sulfate radical-mediated oxidation processes.

answer: @entity3


abstract: PURPOSE: @entity4 ( @entity4 ) is usually @entity6 (+) and rapidly fatal. Anti- @entity6 recombinant immunotoxin LMB-2 had phase I activity limited by immunogenicity and rapid growth. To prevent antidrug antibodies and @entity5 progression between cycles, a phase II trial was performed with LMB-2 after @entity3 and @entity7 . EXPERIMENTAL DESIGN: @entity4 @entity0 received @entity3 and @entity7 days 1 to 3 and 2 weeks later began up to 6 cycles at 3-week intervals of @entity3 and @entity7 days 1 to 3 followed by LMB-2 30-40  g/kg i.v. days 3, 5, and 7. Three different dose levels of @entity3 and @entity7 were used, 20+200 (n = 3), 25+250 (n = 12), and 30+300 mg/m(2) (n = 2). RESULTS: Of 17 @entity0 enrolled and treated with @entity7 and @entity3 for cycle-1, 15 received subsequent cycle(s) containing LMB-2 and were therefore evaluable for response. Lack of antibody formation permitted retreatment in most @entity0 . Of 10 evaluable @entity5 @entity0 receiving 25+250 or 30+300 mg/m(2) of @entity7 and @entity3 , 6 (60%) achieved @entity8 (20%) partial remission (PR), and all 5 with >25% @entity5 cells achieved CR. No responses were achieved in 5 with @entity4 or lower @entity7 and @entity3 doses. Median CR duration for the 6 CRs was 40 weeks. One is without detectable @entity4 at 47 months. @entity1 was mostly attributable to @entity7 and @entity3 . Capillary leak from LMB-2 was non-dose limiting. One @entity0 in CR died of a preexisting @entity2 . CONCLUSIONS: LMB-2, administered with @entity7 and @entity3 to prevent antidrug antibodies and rapid intercycle progression, is highly effective in achieving CR in @entity5 @entity4 . @entity7 and @entity3 dose/schedule is important for safety and efficacy in this high-risk population. Clin Cancer Res; 22(2); 310-8.   2015 AACR.

title: Complete Remissions of @entity4 with Anti- XXXX Recombinant Immunotoxin LMB-2 and Chemotherapy to Block Immunogenicity.

answer: @entity6


abstract: BACKGROUND: Previous studies have demonstrated that @entity0 with @entity8 have higher rates of comorbidities compared to the general population. Despite the clinical and economic burden of @entity10 , there have been few large-scale observational studies focused on this condition. OBJECTIVE: To assess rates of cardiovascular, autoimmune, @entity4 and other conditions in @entity0 with @entity8 or @entity10 ( @entity10 ). METHODS: The data for this retrospective study were obtained from the Clinical Practice Research Datalink (CRPD). Cohorts of @entity0 with @entity8 (n  =  27  672; mild, n  =  22  174, severe, n  =  5498) and @entity10 (n  =  1952) were generated based on the diagnosis made by general practitioner or specialist recorded in CPRD between 2006 and 2010. Frequencies of comorbidities at baseline and incidence rate ratios (IRR) of medical conditions occurring during follow-up were calculated and compared between groups. Cox proportional hazard models were employed to compare hazard ratios (HR) of comorbidities across the same subpopulations previously described. RESULTS: Significant differences in the unadjusted risk of @entity2 , hyperlipidaemia, @entity1 , @entity7 and @entity6 were observed between @entity0 with differing severity of @entity8 or between @entity10 and @entity8 @entity0 . The adjusted HR analyses confirmed @entity0 with severe @entity8 had significantly higher rates of several conditions including @entity1 (1.23; 95% CI: 1.01-1.51) and @entity5 (2.88; 95% CI: 2.25-3.67) compared to @entity0 with mild @entity8 . @entity0 with @entity10 had significantly higher adjusted rates of @entity3 (1.30; 95% CI: 1.01-1.68), @entity5 (6.93; 95% CI: 5.45-8.80) and @entity9 (6.98; 95% CI: 2.37-20.58) compared to those with severe @entity8 . CONCLUSION: @entity0 with mild @entity8 are less affected by comorbid conditions than those with severe @entity8 , and @entity0 with @entity8 are less affected by comorbidities than those with @entity10 . Given the differences observed across severities of @entity8 and between @entity8 and @entity10 , each @entity0 subgroup should be taken into consideration in clinical practice and future research.

title: Prevalence and incidence rates of cardiovascular, autoimmune, and other diseases in @entity0 with XXXX : a retrospective study using Clinical Practice Research Datalink.

answer: @entity10


abstract: OBJECTIVES: This study sought to evaluate the incidence of @entity3 ( @entity3 ), @entity7 ( @entity7 ), and calcified nodule (CN) using optical coherence tomography (OCT) in @entity0 with @entity5 ( @entity5 ); to compare detailed morphologic plaque characteristics of @entity3 , @entity7 , and CN with optical coherence tomography and intravascular ultrasound; and to compare the post-procedure outcomes among @entity3 , @entity7 , and CN. BACKGROUND: The incidence and detailed morphologic characteristics of @entity3 , @entity7 , and CN in @entity5 @entity0 and their outcome after percutaneous coronary intervention (PCI) are unknown. METHODS: A total of 112 @entity5 @entity0 who underwent PCI within 12 h from symptom onset were included. Both optical coherence tomography and intravascular ultrasound were performed following aspiration thrombectomy. RESULTS: The incidence of @entity3 , @entity7 , and CN was 64.3%, 26.8%, and 8.0%, respectively. @entity7 and CN, compared with @entity3 , had more @entity2 (p  < 0.001 and p  < 0.001) and less thin-cap @entity6 (p  < 0.001 and p  < 0.001) as well as smaller plaque burden (p  = 0.003 and p  = 0.001) and remodeling index (p  = 0.003 and p  < 0.001). @entity7 had greater plaque eccentricity index than @entity3 and CN (p  < 0.001 and p  < 0.001). CN had greater calcified arc and shallower @entity4 than @entity3 (p  < 0.001 and p  < 0.001) or @entity7 (p  < 0.001 and p  < 0.001). More than one-half of CN had negative remodeling. @entity7 had a lower incidence of no-reflow phenomenon after PCI than @entity3 (p  = 0.011). CONCLUSIONS: @entity7 was the underlying mechanism in one-fourth of @entity5 . @entity7 was characterized by @entity2 . CN was characterized by superficial large @entity4 and negative remodeling. @entity7 was associated with less @entity1 after PCI.

title: A Combined Optical Coherence Tomography and Intravascular Ultrasound  Study on Plaque Rupture, Plaque Erosion, and Calcified Nodule in  XXXX With ST-Segment Elevation @entity5 : Incidence, Morphologic Characteristics, and Outcomes After Percutaneous Coronary Intervention.

answer: @entity0


abstract: PURPOSE: @entity2 are sometimes encountered in MRIs performed for a variety of reasons. In @entity0 with @entity3 , particularly those with @entity3 , @entity2 are often assumed to be related to their @entity4 focus. We conducted a study to investigate this putative relationship. METHODS: A retrospective study on the incidence of @entity2 was performed in @entity0 seen in our @entity3 Clinic who had CT or MRI scans, interictal EEGs or ictal EEGS. Locations of @entity4 foci in these @entity0 were defined from clinical and electrophysiologic data. RESULTS: Seventeen of 867 @entity0 had @entity2 . Twelve @entity0 had temporal lobe cysts and only 3 of them had temporal lobe @entity4 . Four @entity0 @entity1 and only 1 had @entity4 ipsilateral to the cyst. One @entity0 had a cerebello-pontine angle @entity4 . Thus, clinical manifestations of @entity4 and EEG findings (interictal and/or ictal) indicated that the @entity4 focus was adjacent to the cysts in only 4 @entity0 (23.5%). CONCLUSIONS: Our findings suggest that @entity2 are often an incidental finding in @entity0 with @entity3 and do not necessarily reflect the location of the @entity4 focus.

title: What is the relationship between @entity2 and XXXX foci?

answer: @entity4


abstract: BACKGROUND: Benign tracheo-bronchial @entity1 are rare, but potentially dangerous conditions with life threatening consequences. @entity1 removal should be pursued by methods minimizing the procedural stress. The role of endoscopic treatment, as an alternative to open surgery, remains controversial. OBJECTIVES: report the twelve-years endoscopic experience in Rome, Italy. Fifty-seven benign tracheo- @entity1 were diagnosed and 130 tracheo-bronchial resections by rigid bronchoscopy performed. METHODS: we identified histotypes associated with higher recurrence rate and assessed their relationship with gender, age and tracheo-bronchial location. We provided data on safety and complications and suggested a decision making flow chart to address the @entity0 to endoscopic resection. RESULTS: complete eradication after a single procedure without recurrence at 2 years was obtained in 63.1% of cases (36/57). Need of a second intervention within few months but no further recurrence at follow up was seen in a further 8.8% (5/57). Histotypes associated with recurrence were @entity3 and @entity2 . Seven @entity0 (12.3%) were addressed to surgery because of multiple recurrence. Ten @entity0 (17.5%) were lost at follow up. In case of recurrence, the bronchial biopsy was always repeated and no malignant transformation was observed. No major complications, pneumothorax or @entity5 occurred. CONCLUSIONS: endoscopic treatment of benign tracheo @entity1 is safe and effective, provided that the procedure is carefully and systematically planned. The rate of eradication is satisfactory and the incidence of complications negligible. This will encourage this approach as first line treatment especially in @entity0 , frequently elderly @entity0 , having increased surgical risk due to concomitant @entity4 or major comorbidities.

title: Endoscopic treatment of primary XXXX : Results from a large consecutive case series and decision making flow chart to address bronchoscopic excision.

answer: @entity1


abstract: PURPOSE: The efficacy of three matrix metalloproteinase (MMP) inhibitors with various selectivities ( @entity11 , @entity12 , and @entity13 ) was investigated in a @entity2 model of @entity4 , to examine the roles of @entity10 in @entity8 . The susceptibilities of @entity9 (-/-) and -9(-/-) @entity0 to preretinal neovascularization were investigated in a @entity0 model of @entity1 -induced @entity4 . METHODS: Sprague-Dawley newborn @entity2 were exposed to alternating episodes of 50% and 10% @entity1 (variable @entity1 exposure) to induce @entity8 . Three MMP inhibitors with various selectivity profiles were administered to variable @entity1 -exposed @entity2 via local or systemic routes. Antineovascular efficacy was determined in drug-treated versus vehicle-treated @entity2 pups by computerized imaging of @entity3 diphosphatase (ADPase)-stained retinal flatmounts. Wild-type C57BL/6J and isogenic @entity9 (-/-) and -9(-/-) @entity0 were exposed to 75% @entity1 followed by normoxia. The @entity0 were killed immediately before or after the normoxic exposure, and eyes were either harvested for retinal dissection and flatmounting or were paraffin embedded and sectioned. @entity8 were assessed by @entity3 diphosphatase staining of retinal flatmounts and by counting preretinal nuclei of @entity5 and @entity6 -stained retinal sections, respectively. RESULTS: @entity11 , @entity12 , and @entity13 had no effect on normal development of the @entity2 retinal vasculature, regardless of dose or route of administration. Intravitreal injection of @entity11 (broad-spectrum) immediately after variable- @entity1 exposure and 2 days after exposure resulted in 78% and 82% inhibition of @entity8 , respectively. @entity12 ( @entity9 - and -9-selective inhibitor) and @entity13 ( @entity9 -selective inhibitor) resulted in 65% and 52% inhibition, respectively, when administered by intravitreal injection immediately after variable- @entity1 exposure. Intraperitoneal injection of 5, 15, and 50 mg/mL @entity12 or @entity13 for 6 days after variable @entity1 exposure resulted in 22% to 39% and 0% to 31% inhibition of neovascularization, respectively. @entity12 and @entity13 administered by oral gavage at doses of 3, 10, or 30 mg/mL provided up to 42% and 86% inhibition of neovascularization, respectively. The average vascular areas of retinas from @entity9 (-/-) or -9(-/-) @entity0 at postnatal day 12 were not significantly different from the wild-type control. There was a 75% (P < 0.001) and 44% (P < 0.01) reduction in preretinal neovascularization in @entity1 -exposed @entity9 (-/-) and -9(-/-) @entity0 at postnatal day 19, respectively, compared with wild-type control @entity0 . CONCLUSIONS: The results of this study suggest that @entity9 plays a predominant role in retinal angiogenesis in both the @entity0 and @entity2 models of @entity1 -induced @entity4 . Furthermore, @entity9 inhibition may be a viable therapeutic approach for @entity7 characterized by @entity8 .

title: Pharmacologic and genetic manipulation of MMP-2 and -9 affects XXXX in rodent models of OIR.

answer: @entity8


abstract: @entity6 of the major salivary gland is a rare condition. We report on a case of bilateral aplasia of the submandibular glands associated with a @entity3 . A 62-year-old @entity0 came to our department complaining of a 3-year history of left submandibular swelling. She had no notable family or personal medical history. On physical examination of the head and neck region, a 30 mm, non-tender mass was palpated in the left submandibular area. On imaging examinations including ultrasonography and CT, lack of the right submandibular gland and a left submandibular mass with @entity2 were demonstrated. Fine needle aspiration cytology resulted in blood elements only. Functioning tissue could not be observed in the bilateral submandibular glands on @entity4 scintigraphy. We performed a left submandibular @entity1 extirpation. Intraoperatively, the left submandibular gland and duct were missing. On pathologic examination, the @entity1 was found to be a @entity5 . The parotid and sublingual glands were recognized bilaterally on postoperative MRI. Her postoperative condition was satisfactory. This condition may be due to the dysfunction of several factors, such as fibroblast growth factors, related to gland differentiation.

title: [A case of bilateral aplasia of the submandibular glands associated with a unilateral submandibular XXXX ].

answer: @entity5


abstract: OBJECTIVE: During @entity3 ( @entity3 ), a transient @entity4 and secretion triggers @entity5 , which is followed by a substantial increase in mortality. Recent findings in cellular models indicate that HDL may act on @entity2 homeostasis by improving insulin sensitivity and secretion. In this study, we explored this potential effect in @entity0 during the acute phase of @entity3 . METHODS: Plasma @entity2 , insulin and C-peptide were measured at admission in the first 24h and on the fifth day after @entity3 with ST-segment elevation in 183 consecutive non- @entity1 @entity0 . @entity0 were divided into HDL-C quartiles for the analyses (Q1: <31, Q2: 31-38, Q3: 38-47 and Q4: >47mg/dL). The Homeostasis Model Assessment version 2 was used to assess insulin sensitivity (HOMA2S) and beta-cell function (HOMA2B). RESULTS: On admission, no difference was found between the quartiles in @entity2 (p=0.6), insulin (p=0.6) or C-peptide (p=0.5) levels, HOMA2S (p=0.9) or HOMA2B (p=1.0). On the fifth day there was a reduction in @entity2 levels whose intensity was directly proportional to the HDL-C quartile (p<0.001). At the same time, there was a reduction in plasma insulin (p<0.001) and C-peptides (p<0.001) whose magnitude was inversely proportional to the HDL-C quartile. Consistently, the increase of HOMA2S (p<0.001) and HOMA2B (p=0.01) were also positively associated with HDL-C levels. Furthermore, plasma HDL-C levels were inversely and independently associated with blood @entity2 change during the acute phase. CONCLUSION: This study demonstrates the association between low plasma HDL-C levels and increased duration of @entity5 during @entity3 and suggests in @entity0 the interaction between HDL and insulin secretion and sensitivity.

title: High plasma HDL-C attenuates XXXX during acute phase of @entity3 .

answer: @entity5


abstract: @entity0 have significant exposures to @entity10 , as these chemical plasticizers are ubiquitously present in flexible plastics. Recent epidemiological evidence indicates that @entity0 born to @entity0 exposed to @entity10 during pregnancy have an increased incidence of @entity3 and @entity6 , signs of a condition referred to as @entity11 ( @entity11 ). @entity11 is thought to develop as a result of environmental factors that cause a testicular disturbance at an early fetal stage with a resultant spectrum of clinical @entity6 , ranging from @entity7 to increased risk for development of @entity1 . Proposed environmental factors in the etiology of @entity11 include endocrine disrupting compounds such as the @entity10 . Leydig cells have been classified as one of the main targets for @entity8 @entity2 in the body based on studies in rodents. In support of this hypothesis, two Leydig cell products - insulin-like growth factor 3 ( @entity12 ) and @entity5 (T) - are both suppressed after @entity9 exposures. Both fetal and adult generations of Leydig cells are affected by @entity8 , although their sensitivities may differ. In rodent models, when pregnant dams are exposed to @entity8 , fetal Leydig cells form enlarged clusters that are retained in the testis even after birth, in contrast to untreated controls. Despite the retention of fetal Leydig cells, however, their numbers and average cell volume of total in exposed males are reduced, as are @entity12 production and steroidogenic competence. These alterations are directly associated with clinical features of @entity11 , including @entity4 and impaired spermatogenesis.

title: @entity8 XXXX in Leydig cells: developmental timing and dosage considerations.

answer: @entity2


abstract: UNASSIGNED: Elderly @entity0 with acute @entity1 are prone to severe disability, @entity5 ( @entity5 ), and resultant complications. A @entity3 ( @entity3 ), based on the orthopedic suspension traction system commonly used for conservative treatment of @entity7 and uncomplicated adult pelvic @entity2 , was developed to facilitate @entity5 management in @entity0 immobilized secondary to an acute @entity1 . To evaluate the effectiveness and safety of the system, a prospective, randomized, controlled study was conducted between October 2009 and July 2012. Two hundred (200) elderly, bedridden, hospitalized @entity0 with acute, nonchronic @entity1 were randomly assigned to receive routine @entity5 nursing care (ie, individualized dietary modification, psychological support, health education, and social support for caregivers and family members [control group]) or routine incontinence care plus the @entity3 (experimental group) during the day. Rates of perianal fecal contamination, skin breakdown, incontinenceassociated @entity6 , pressure ulcer development, and @entity4 ( @entity4 ) were significantly lower in the @entity3 than in the control group (P <0.05). Length of hospitalization and costs of care were also lower in the @entity3 group (P <0.05). @entity0 quality-of-life (QoL) and @entity5 QoL scores were similar at baseline but significantly higher (better) at the 6-month follow-up interview in the @entity3 than in the control group (P <0.05). In this study, the rate of @entity5 -associated morbidities was lower and 6-month @entity0 QoL scores were higher in the @entity3 than in the control group. No adverse events were observed, and all @entity0 completed the study. Further clinical studies are needed to examine the long-term effects of @entity3 use among neurologically impaired @entity5 @entity0 .

title: A Prospective, Randomized, Controlled Study of a Suspension Positioning System Used With Elderly Bedridden XXXX with @entity5 .

answer: @entity0


abstract: The nasal angiocentric T-cell-natural killer cell lymphoma is an aggressive @entity1 , exceptional in Tunisia, which is observed especially in Asia, Mexico and South America. We report the case of an 11-year-old @entity0 , presenting with an exuberant and @entity1 of the right nasal pit. Radiological investigation evidenced a right ethmo  do-frontal @entity1 . Evolution was characterized by the installation of @entity3 and @entity2 , the evidenciation of a mass within the head of the pancreas that compressed the extra hepatic biliary duct and Wirsung's canal and was associated to @entity6 . Biopsy under ultrasound revealed a histiocytic nature. Nasal biopsy found histiocytic and lymphocytic cells and led to a diagnosis of @entity7 . The absence of improvement under antibiotic treatment and the development of @entity2 with leuconeutropenia oriented towards the diagnosis of a non-Hodgkinian @entity5 . Medullary biopsy and immunohistochimic study confirmed a T/NK cells lymphoma, with medullary invasion. The @entity0 died from acute @entity4 . The authors insist on the rarity of this bipolar location, in particular in @entity0 , emphasize the difficulty of the diagnosis and review the literature.

title: [Nasal angiocentric T cell-natural killer cell lymphoma with pancreatic localisation in a XXXX ].

answer: @entity0


abstract: PURPOSE: The alpha angle is used to quantify in a single plane the head-neck junction deformity of cam @entity2 ( @entity2 ). When the deformity overlaps the superior retinaculum, @entity3 in this area can jeopardise intra-articular vascular structures. This study proposes a new angular measure of the linear radial extension of @entity1 as a planning tool for bone resection and compares the accuracy of @entity3 using open and arthroscopic surgery. METHODS: Twenty-five symptomatic @entity0 operated on for @entity2 were included in this study. Radial magnetic resonance imaging (MRI) was done before and after surgery. Bi-dimensional coordinates of the vascular foramina and radial extension of the deformity (omega angle) were measured. This extension was correlated with the vascular foramina location and alpha-angle value. Accuracy of resection and hip function were evaluated before and after surgery. RESULTS: The cam lesion frequently extended posteriorly. No relation between values of alpha and omega angles was found. Cam resection was complete in 88  % of cases; there was a significant improvement in outcome score after surgery. CONCLUSIONS: This study showed that alpha angle, measured in one plane, was not a predictor of the radial extension of @entity1 . To achieve a full resection, it was frequently necessary to extend the @entity3 over the retinacular area. Pre-operative determination of the omega angle and location of the vascular foramina helped improve cam resection safety and accuracy.

title: Morphologic and angular planning for cam resection in XXXX : value of the omega angle.

answer: @entity2


abstract: BACKGROUND: @entity1 are occasionally found in the lymphoid or solid organs of @entity0 with common variable @entity3 . OBJECTIVE: To examine the clinical and immunologic conditions in @entity0 with common variable @entity3 who have @entity4 . DESIGN: Case series. SETTING: Large tertiary care medical center. @entity0 : 17 hypogammaglobulinemic @entity0 with common variable @entity3 whose organ or tissue biopsy samples contained noncaseating @entity4 . MEASUREMENTS: Results of lymphocyte function tests. RESULTS: Eight of 17 @entity0 had @entity4 at some point before @entity7 was diagnosed. Sixteen of the 17 had @entity5 . Although 14 @entity0 received standard treatment with intravenous immunoglobulin, they have had substantial illness, including frequent @entity6 . CONCLUSIONS: Dysregulated T-cell function or macrophage activation may have been involved in formation of @entity4 and @entity2 in hypogammaglobulinemic @entity0 with common variable @entity3 . @entity3 may have contributed to the severity of illness in these @entity0 .

title: @entity4 in common variable XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity4 ( @entity4 ) are often prescribed to @entity1 @entity0 aiming to reduce @entity3 risk. The goal of this meta-analysis was to determine if @entity4 indeed reduced the risk of @entity3 and @entity2 in @entity1 @entity0 compared to regular diets (RD). We identified studies in @entity1 @entity0 that compared the effect of @entity4 vs. RD on the risk of @entity3 and mortality of any cause. The overall effect was calculated by use of a random effects model. Four studies were identified encompassing 918 @entity0 . There was no difference in major @entity3 or mortality rates between @entity4 and RD groups. When analyzing for the overall composite outcome of any @entity3 or fever, the hazard ratio was significantly higher in the @entity4 arm (relative risk = 1.18, confidence interval: 1.05 to 1.34, P= 0.007). When the analysis was restricted to only the randomized trials, both groups had a comparable composite outcome. This meta-analysis shows no superiority with respect to mortality or @entity3 of using a neutropenic diet in @entity1 @entity0 . Larger studies are needed that study a broader range of nutritional issues, including the microbiome, in this @entity0 population. Until then, it may be time to relax the restrictions of @entity4 .

title: The Effect of a Neutropenic Diet on Infection and Mortality Rates in @entity1 XXXX : A Meta-Analysis.

answer: @entity0


abstract: WHAT IS KNOWN AND OBJECTIVE: @entity8 ( @entity8 ) is an acute self-limiting systemic @entity9 with specific predilection for the coronary arteries that affects previously healthy young @entity0 and @entity0 . It is the leading cause of childhood-acquired @entity6 in the developed world. Although the stimulus for the cascade of @entity1 in @entity8 is unknown, prompt treatment within 10 days of symptom onset has been shown to improve clinical outcomes and reduce the risk of coronary artery complications. Standard initial therapy is intravenous immunoglobulin (IVIG) and @entity2 . Non-responders to initial therapy remain a challenge. This present review summarizes the treatment options for initial and refractory @entity8 , including the role of @entity4 and other immunosuppressive therapies. METHODS: Literature search using PubMed database to identify pharmacologic studies in @entity8 using the terms @entity8 , intravenous immunoglobulin, refractory, @entity5 , infliximab, @entity3 , @entity10 , high risk from January 1988-May 2015 was performed. Bibliographies of selected references were also evaluated for relevant articles. Results were limited to those published in English. All articles identified from the PubMed searches were evaluated. RESULTS AND DISCUSSION: Initial IVIG therapy results in rapid resolution of clinical symptoms in 80-90% of @entity0 and has been shown to reduce the risk of @entity7 . Although concomitant @entity2 remains the standard of care for the initial management of @entity8 , the evidence to support its efficacy in improving coronary artery outcomes are lacking. Initial therapy with @entity5 in addition to intravenous immunoglobulin and @entity2 improves outcomes in @entity0 in Japan. However, identifying @entity0 at high risk who may benefit from additional @entity5 in heterogeneous populations has been challenging. Therapeutic options for non-responders to initial therapy are also challenging given the paucity of data. @entity0 who fail to respond to the first dose of IVIG will most often receive a second dose. @entity0 who fail to respond to two doses of IVIG present a unique challenge as the appropriate treatment remains uncertain. Although their effectiveness remains unproven, treatment with infliximab, @entity3 or @entity10 may be considered in those @entity0 who fail multiple doses of IVIG and @entity4 . WHAT IS NEW AND CONCLUSION: The role of @entity4 in high-risk non-Japanese @entity0 is unclear, with the biggest challenge being early identification of @entity0 at high risk of developing adverse coronary artery outcomes. Limited data evaluating other immunosuppressive agents are available and should be reserved for @entity0 failing two doses of IVIG. Although recent advances in research have broadened our understanding of the epidemiology, genetic susceptibility and pathogenesis of @entity8 , the aetiology of @entity8 remains unclear. Ongoing research will help determine more precise pathogenesis and may assist in developing a diagnostic test as well as identifying new targets for more precise treatment interventions.

title: XXXX : a comprehensive review of treatment options.

answer: @entity8


abstract: Recent experimental evidence underscores the contribution of intestinal bacteria to the inflammatory process of @entity1 . This open study examined the efficacy and safety of combination @entity5 and @entity3 for @entity0 with active @entity1 and/or colon. Seventy-two @entity0 with active @entity1 (n = 27), ileocolon (n = 22) or colon (n = 23) were treated with @entity5 500 mg bid and @entity3 250 mg tid for a mean of 10 weeks. Clinical remission was defined as a Harvey-Bradshaw index of three points or less; an index reduction of at least three points indicated a clinical response. Clinical remission was observed in 49 @entity0 (68%), and 55 @entity0 (76%) showed a clinical response. A clinical response was noted in 29 of 43 @entity0 (67%) who were not taking concurrent @entity2 treatment and in 26 of 29 @entity0 (90%) receiving @entity2 (mean dose of 15 mg/day). A clinical response also occurred in a greater proportion of @entity0 with @entity4 , with or without ileal involvement (84%), compared with @entity0 with @entity6 alone (64%), and in @entity0 without resection (86%) compared with those with previous resection (61%). Five patients discontinued antibiotics because of adverse events. After a mean follow-up of nine months, clinical remission was maintained in 26 @entity0 off treatment and in 12 @entity0 who continued antibiotic therapy. @entity5 in combination with @entity3 is well tolerated and appears to play a beneficial role in achieving clinical remission for @entity0 with active @entity1 , particularly when there is involvement of the colon.

title: Combination XXXX and @entity3 for active @entity1 .

answer: @entity5


abstract: @entity3 -mediated signaling is involved in a variety of functions in @entity0 cells. To determine whether this is true for immunocompetent cells, we generated mutant (Lck- @entity11 -) @entity1 in which the @entity11 gene was deleted in a T cell-specific manner using the Cre/loxP system. These @entity1 showed @entity2 cell development. Thymi at most ages were small and their architecture was disorganized. This defect was not due to increased thymocyte apoptosis but to decreased cell proliferation. T cell development was found to be severely arrested at the @entity4 /CD8 double-negative 3 stage and the thymus contained very few double-positive or single-positive (SP) mature thymocytes. The mutant thymocytes showed impaired proliferative responses to anti- @entity9 monoclonal antibody (mAb) stimulation or to the cytokines @entity5 , @entity8 or @entity6 . In the spleen, the numbers of mature SP T cells were decreased and their proliferative responses to anti- @entity9 plus @entity5 or to anti- @entity10 mAb were impaired. A severe impairment of @entity9 -induced expression of @entity7 was also observed. These data suggest that @entity11 plays a critical role in the proliferation of thymocytes, which is necessary for early T cell development.

title: T cell-specific gene targeting reveals that XXXX is required for early T cell development.

answer: @entity11


abstract: PURPOSE: We present a series of @entity5 following a pubovaginal sling procedure due to synthetic and nonsynthetic materials and discuss their management and continence outcome. MATERIALS AND METHODS: During a 3-year period 57 @entity0 underwent urethrolysis for @entity7 after receiving a pubovaginal sling. @entity5 , defined as sling material entering the urethral lumen, was present in 9 @entity0 and this cohort comprises the focus of our review. In 3 @entity0 the eroded material was synthetic, that is ProteGen (Boston Scientific, Natick, Massachusetts) in 2 and @entity6 in 1. This condition was treated with removal of the whole sling, multilayer closure of the erosion and selective use of a Martius flap. In 6 @entity0 the eroded material was nonsynthetic, that is allograft fascia in 5 and autograft fascia in 1. This condition was treated with sling incision and multilayer closure of the urethra. Preoperative assessment included a urogynecologic questionnaire, measurement of pad use, a voiding diary, cystourethroscopy and videourodynamics. Postoperatively similar parameters were used to assess continence outcomes and the need for subsequent procedures. RESULTS: Nine @entity0 were followed 30 months after urethrolysis. All 9 @entity0 had some manifestation of @entity3 following the pubovaginal sling procedure, including urinary retention in 4, urge @entity2 in 3 and mixed @entity2 in 2. Urinary retention resolved in 3 @entity0 and urge @entity2 resolved in 4. @entity4 ( @entity4 ) persisted in 2 of the 3 @entity0 in the synthetic group, while no @entity0 in the nonsynthetic group had recurrent @entity4 . There were no recurrent @entity5 or @entity1 in either group. CONCLUSIONS: @entity5 after a pubovaginal sling procedure can occur irrespective of the sling material. However, recurrent @entity4 is not an invariable outcome of the management of @entity5 following the pubovaginal sling procedure.

title: XXXX after synthetic and nonsynthetic pubovaginal slings: differences in management and continence outcome.

answer: @entity5


abstract: UNASSIGNED: Hemodialysis catheters are vital for @entity1 @entity0 . Permanent tunneled dialysis catheters may be inserted through the jugular, subclavian, and femoral veins. In this paper, we aimed to present the computed tomography findings of a @entity1 @entity0 who had referred our clinic with @entity3 and @entity5 symptoms. This @entity0 had a formerly inserted hemodialysis catheter for @entity1 and her catheter was found to be extending towards the middle hepatic vein with the tip leaning onto the parenchyma. Hemodialysis catheters can provide instant vascular access and can also be used for the consecutive procedures. Permanent hemodialysis catheters are ideal for long-term use when placing an @entity6 is contraindicated or is no longer possible under conditions like advanced @entity4 , peripheral @entity2 or short life expectancy. The internal jugular, subclavian, the femoral veins, and the inferior vena cava can be used for catheter insertion. The tip of the catheters inserted in the neck or the thorax must extend to the vena cava superior. Catheter malposition may both lead to fatal outcomes and ineffective dialysis. It is important to obtain chest X-rays after the procedure, particularly to detect catheter malposition.

title: A rare cause of XXXX : Catheter in the middle hepatic vein.

answer: @entity3


abstract: Subcoracoid transfer of the pectoralis major has recently been described as a reconstruction for subscapularis insufficiency. The purpose of this study was to examine the surgically relevant anatomy of this transfer. The importance of understanding this anatomy was recently highlighted to us following our encounter with musculocutaneous neuropraxia in 2 @entity0 after transfer of the entire pectoralis major, one deep to the musculocutaneous nerve. Dissections were performed on 20 fresh, whole @entity0 cadavers in which the entire pectoralis major muscle, medial and lateral pectoral nerves, and musculocutaneous nerve were explored and quantified. The relationship between the pectoralis major and the conjoined tendon was studied in situ and after simulated transfers. The medial and lateral pectoral nerves were located far medial to the pectoralis major tendon insertion and appeared to be safe from injury as long as surgical dissection remained lateral to the pectoris minor and less than 8.5 cm from the humeral insertion. Transfer of the pectoralis major superficial to the musculocutaneous nerve created less @entity3 . Because proximal innervation of the coracobrachialis and short head of the @entity1 is not an uncommon occurrence, a split pectoralis major transfer, release of the proximal musculocutaneous branches, or debulking of the pectoralis major muscle belly may be required in some instances to prevent @entity2 on the nerve. Because of the variability and location of the musculocutaneous nerve, it should always be visualized operatively. Transfer of the pectoralis major tendon lateral to the @entity1 tendon appeared to best restore the muscle length- @entity2 relationship.

title: Anatomic evaluation of the subcoracoid pectoralis major transfer in XXXX cadavers.

answer: @entity0


abstract: Concurrent falls in milk production and electrical resistance of composite milk were examined in Israeli Holstein @entity0 . The @entity0 were milked three times a day by a system that recorded yield and the lowest electrical resistance in the composite milk from the four glands. The study included two groups: @entity0 that experienced on day 0 a decline in resistance and milk production > or = 20% from the mean of the previous 9 d (62 @entity0 , case group) and @entity0 that experienced no such episodes over 9 d before and after a fixed day (118 @entity0 , control group). Bacteriological status and somatic cell count (SCC) or @entity2 test scores were assessed on the fixed day in the control group, and on days 0, 1 and 2 in the case group. @entity2 test scores greater than 2 and SCC thresholds of 5 x 10(5) cells/ml were used to create two classes of leucocytosis. There was no statistically significant difference between the two groups in frequency distributions of pathogens and their types: in 30% of @entity0 infection was not detected, 33% were infected by major pathogens (95% of which were @entity1 ), and 53.5% by minor pathogens (80% Micrococcus spp.). @entity0 in the case group had lower milk production during the 8 d following day 0. Mean electrical resistance was lower in infected @entity0 and particularly in @entity0 infected by Staph. aureus. High leucocytosis was associated with reduced electrical resistance in both groups, and was found in 93% of @entity0 in the case group v. 25% in the control group. The results suggest that falls in electrical resistance of milk and in milk production were not linked to a specific pathogen, and were followed by 3-8 d of reduced milk production and electrical resistance. The study suggests that there are episodic aggravations in mammary health that do not evolve into clinical @entity2 but may induce significant losses in milk yield and quality.

title: Subclinical XXXX assessed by deviations in milk yield and electrical resistance.

answer: @entity2


abstract: PURPOSE: The purpose of this study was to determine the outcomes for @entity0 with @entity2 Greenfield vena caval filters (TGFs) and, in particular, to evaluate the effect of filter leg distribution on recurrent @entity3 ( @entity3 ) and @entity1 . METHODS: Physical examination, abdominal plain films, and duplex ultrasound examinations of the inferior vena cava and lower extremities were obtained annually and recorded in a Filter Database. RESULTS: Seven hundred eighty-three TGFs have been placed since 1989. Follow-up was available for 373 @entity0 , or 65% of the surviving @entity0 , over 1 to 84 months (mean, 33 months). Asymmetry was identified in 42 placements (5%), and 35 of these @entity0 had at least one follow-up examination. The overall incidence of recurrent @entity3 was 3.2% (12 of 373), whereas the caval patency rate was 97.8% (265 of 271). These outcomes were not significantly different for @entity0 who had asymmetric filters (p = 0.1 and 0.18, respectively). CONCLUSIONS: Filter leg distribution does not appear to be associated with an increased incidence of recurrent @entity3 or @entity1 . These data support earlier in vitro findings. The long-term results with the TGF are comparable with the results of the original stainless steel Greenfield filter.

title: Limb asymmetry in XXXX Greenfield filters: clinically significant?

answer: @entity2


abstract: Severe @entity3 is widely distributed throughout the world, showing a high prevalence in developing countries. Experimental animal models have been useful to study the effects of @entity3 at different levels and ages. Apoptosis is a well recognised process of cell death occurring under several physiological and pathological conditions. It represents the principal mechanism involved in cell selection in the thymus. Thymocyte apoptosis induction by @entity1 is one of the best characterised experimental models of programmed cell death. The aim of the present study was to determine whether severe @entity3 increased spontaneous and/or @entity1 -induced apoptosis in vivo in thymocytes of experimentally malnourished @entity0 during lactation. Thymocytes were obtained from malnourished @entity0 at weaning (21d of age). Apoptosis frequency was estimated by the terminal transferase-mediated @entity2 nick end labelling assay. Spontaneous apoptosis was 1.9 (sd 1.0) % in well nourished @entity0 in contrast to 13.3 (sd 3.8) % in malnourished animals; this is seven times greater (P<0.001). Interestingly, the frequency of @entity1 -induced apoptosis was similar in both groups of animals (47.9 (sd 10.1) % in well nourished @entity0 and 53.8 (sd 8.0) % in malnourished @entity0 ). The results obtained in the present study indicate that @entity3 is associated with a significant increase of spontaneously apoptotic cells. In addition, the data showed that the fraction of thymocytes susceptible to @entity1 -induced apoptosis was similar in well nourished and malnourished animals. The greater levels of spontaneously apoptotic cells associated with @entity3 could be related to alterations of the microenvironment of the thymus and/or to an obstruction of early thymocyte maturation.

title: Flow cytometric analysis of spontaneous and XXXX -induced apoptosis in thymocytes from severely malnourished @entity0 .

answer: @entity1


abstract: Because metabolism is a determinant of the ventilatory chemosensitivity, we tested the hypothesis that the ventilatory response to acute and prolonged @entity3 is adjusted to the circadian oscillations in @entity0 consumption (VO2). Adult @entity1 were instrumented for measurements of body temperature (T(b)) and activity by telemetry. Pulmonary ventilation (VE) was measured by the barometric method and VO2 by the flow-through method. In the acute experiments, 16 conscious @entity1 entrained to a 12:12-h light (L)-dark (D) cycle (lights on 7:00 AM) were exposed to air, 2%, and then 5% @entity2 in normoxia (30-45 min each) at 11:00 AM and 11:00 PM. In a separate group of seven @entity1 , simultaneous recordings of all variables were made continuously for 3 consecutive days in air followed by 3 days in 2% @entity2 in normoxia, in a 12:12-h L-D cycle (lights on 7:00 AM). In air, all variables were significantly higher at night, whether @entity1 were studied acutely or chronically. Acute @entity2 exposure had similar significant effects at 11:00 AM and 11:00 PM on VE (approximately 25 and 100% increase with 2 and 5% @entity2 , respectively) and @entity4 (approximately 8% drop with 5% @entity2 ), such that the hyperventilatory response (% increase in VE/VO2 from air) was similar at both times. Chronic @entity2 breathing increased VE at all times of the day, but less so during the L phase (approximately 15 vs. 22% increase in L and D, respectively), when activity was lower. However, VO2 was reduced from the air level (approximately 10% drop) in the L, such that the VE/VO2 response was similar between L and D. The same result was obtained when the VE/VO2 response was compared between the L and D phases for the same level of activity. These results suggest that, throughout the day, the hypercapnic hyperpnea, whether during acute or prolonged @entity2 , is perfectly adjusted to the metabolic level.

title: Circadian pattern of ventilation during acute and chronic @entity3 in conscious adult XXXX .

answer: @entity1


abstract: UNASSIGNED: 7063 Background: The addition of @entity2 (G) to doublet chemotherapy with @entity12 (C) and @entity7 (P) has demonstrated to improve clinical outcome of advanced stage IIIB and IV @entity5 in a phase II-III study, albeit with significant hematologic @entity3 . In a previous dose finding study, we identified a safe GEMCAP regimen based on dose-limiting @entity3 . METHODS: @entity0 aged 18-75 years, with ECOG PS 0-1, and unresectable clinical stage IIIA @entity5 , or stage IIIB suitable for definitive radiation treatment were treated in a phase II study with C AUC 5 i.v., P 175 mg/m(2) i.v. on day 1, and G 800 mg/m(2) i.v. on days 1 and 8, every 3 weeks for 3 cycles. @entity0 with stage IIIA disease in response following GEMCAP were reassessed for surgery; those with unresectable stage IIIA disease and stage IIIB, were treated with radiotherapy. Primary endpoint was response rate. Secondary endpoints included: @entity3 , progression-free survival (PFS), resection rate, and @entity8 ( @entity8 ). RESULTS: Of the 53 enrolled @entity0 , 42 were males, 11 females, 29 (55%) had stage IIIA, 24 (45%) stage IIIB @entity5 , 47 (89%) had a PS 0. Forty partial responses and one complete response were observed, for an overall response rate of 80%. G3-4 and G2 @entity3 , occurring in >=  5% of @entity0 , included: @entity10 (19-8%), hypertransaminemia (11-2%), @entity4 (6-0%), G3-4 @entity3 ; @entity10 (34%), @entity9 (25%), @entity4 (15%), @entity11 (13%), osteomialgya (11%), hypertransaminemia (6%), @entity6 (9%), G2 @entity3 . With a median follow-up of 20 months (range, 6-77) PFS was 10.5 months (95% CI, 9.9-11.4); @entity8 was 21.1 months (95% CI, 19.6-22.9). Thirteen @entity0 were operated, for a resection rate of 44%. CONCLUSIONS: The GEMCAP regimen at the dose employed produced high response and resection rate, with acceptable @entity3 , as induction chemotherapy for clinical stage III @entity5 . PFS and @entity8 compared favourably with that expected for clinical @entity1 .

title: Induction chemotherapy with @entity2 - XXXX - @entity7 (GEMCAP) in @entity1 ( @entity5 ).

answer: @entity12


abstract: Assisted reproductive technologies (ART) used in fertility clinics include @entity1 ( @entity1 ) and @entity4 ( @entity4 ), followed by embryo transfer into the biological or a surrogate mother. Over 1,000,000 liveborn offspring--an estimated 1 in 150 United States newborns--have been produced worldwide by ART since 1978. @entity1 appears to produce healthy @entity0 in singleton pregnancies, though concerns remain regarding preterm deliveries, multiple pregnancies, as well as the longer-term consequences of all ART procedures. Clinical studies remain difficult to interpret and subject to confounding variables, as developmental problems may be due to a parent's reproductive conditions rather than, or in addition to, an ART procedure. Also, because of expense and time commitments, the United States ART clinical population is not fully representative of society diversities. This socio-economic skewing might compensate for negative effects, masking small, or modest @entity2 . Embryo splitting (ES), an ART procedure used only with animals, can produce genetically identical offspring. ES involves dividing four- to eight-cell embryos into separate blastomeres and implanting them into empty zona pellucida, followed by embryo transfer. Although these ART techniques have produced nonhuman primate offspring, there has been no research on behavioral safety. Here, we report the first study of behavioral development by @entity3 @entity0 produced through ES, @entity4 , and @entity1 . We assessed neonatal reflexes, self-feeding ability, recognition memory, object concept attainment, simple discrimination learning and reversal, and learning set (LS) acquisition. Although the sample sizes are small, we found no overall ART group delayed development. Surprisingly, the ES and @entity4 monkeys appeared to be accelerated in attaining age milestones involving sensory-motor behaviors and a difficult Well Hiding object concept task. We conclude that macaque monkeys may provide an excellent model for the study of early @entity0 development by offspring of parents with conditions requiring ART pregnancies, as well as a model for the behavioral study of genetic-environment interactions using identical twins produced by ES.

title: Neonatal behavior and XXXX cognitive development in @entity3 produced by assisted reproductive technologies.

answer: @entity0


abstract: To study the dorsal surface of the @entity0 tongue using a @entity3 ( @entity3 ), tissue specimens were taken from the anterior part of the tongues of 15 individuals aged from 21- to 28-years-old. The @entity1 -fixed samples were processed routinely for @entity3 . With @entity3 the surface of the normal tongue mucosa was shown to be rather evenly covered by filiform papillae, with some @entity2 scattered among them. @entity2 consisted of two parts: the body and hairs. The mucosal surface of the body was smooth; the squamous epithelial cells were polygonal, and their boundaries were prominent. On the surface of the superficial epithelial cells were parallel or branching microplicae. Each filiform papilla had 6-10 hairs, which were scaled and covered by an extensive plaque of microorganism. The upper surface of the @entity2 was smooth; only a few desquamating cells were seen. The superficial cells had a pitted appearance and cell boundaries overlapped. Taste pores, up to 3 pores in a single papilla, were found on the upper surface. Desquamation was more pronounced on the base of the @entity2 than on the upper surface. In almost all @entity2 some hairs protruded from the base. Parallel microplicae were found on the surface of the superficial cells of the base. The structure and function of the @entity0 tongue, as well as the microplicae of its superficial cells, are compared to those of various species of animals.

title: A scanning electron microscopic study of the dorsal surface of the XXXX tongue.

answer: @entity0


abstract: Anatomical studies suggest that sites of @entity6 are subject to early @entity2 . Coronary angiography is unable to confirm the lesions or provide information about their nature. On the other hand, endocoronary ultrasound is able to identify and, it is hoped, to determine the frequency and composition of the lesions. Nineteen @entity0 with @entity1 and angiographically normal or subnormal coronary arteries were included in a prospective study (16 @entity0 and 3 @entity0 : average age 53 +/- 10 years). Four @entity0 had spontaneous @entity4 and in the other 15, @entity4 was induced by intravenous injection of @entity7 (6 micrograms/kg). After countering the @entity4 with @entity8 , the site of @entity4 and adjacent segments were examined by endocoronary ultrasound. Localised @entity5 which was stenotic in 14 cases and obstructive in 5 cases, was observed. The ECG was unchanged in 4 cases and showed ST-T segment changes in 15 cases. The artery affected was the left anterior descending in 10 cases, the left circumflex in 2 cases and the right coronary in 7 cases. A plaque of @entity3 , defined as significant intimal thickening, was detected in 18 out of the 19 cases. This @entity3 was classified as soft in 17 cases and hard in one case. The authors conclude that @entity5 is not only associated with a plaque of @entity3 , nearly always suspected at coronary angiography, but also its composition is nearly always soft (lipidic) from ultrasonographic data.

title: [Frequency and nature of @entity3 at the site of XXXX of angiographically normal or subnormal coronary arteries: an endocoronary ultrasonographic study].

answer: @entity4


abstract: UNASSIGNED: Behavioral sensitization to @entity3 ( @entity1 ) manifests as a progressive and enduring @entity4 with repeated drug exposure. However, not all @entity0 sensitize to @entity1 and the neuronal mechanisms mediating vulnerability and resistance to @entity1 sensitization remain unclear. We examined regional brain expression of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc) in order to identify brain areas in which neuroplastic changes may contribute to the development and expression of @entity1 sensitization. Male DBA/2J @entity0 received 5 biweekly injections of @entity1 (2.2g/kg, i.p.) or saline (SAL). They were categorized as high- ( @entity5 ) or @entity2 ( @entity2 ) on the basis of final locomotor activity scores. In both @entity2 and @entity5 @entity0 sacrificed after the last sensitization injection, Arc expression was decreased throughout the brain in comparison to SAL animals. A similar pattern was seen in @entity0 sacrificed after an @entity1 challenge two weeks after the last sensitization injection. However in this cohort, Arc expression was significantly increased in the central amygdala (CeA) in @entity2 @entity0 and in SAL @entity0 receiving @entity1 for the first time. No significant increases in Arc expression were seen in brains of sensitized ( @entity5 ) animals. These results indicate an acute @entity1 challenge results in different patterns of Arc expression in brains of @entity2 , @entity5 , and SAL @entity0 . The dramatic increases in Arc expression in the CeA in @entity2 and SAL @entity0 showing little or no behavioral activation suggests that neural activity in this region may serve to inhibit the stimulant effects of @entity1 . The observation that @entity5 @entity0 do not show increases in Arc expression with an @entity1 challenge suggests the possibility that increased tolerance to the Arc-inducing effects of @entity1 may be a factor in behavioral sensitization.

title: Localized brain differences in Arc expression between XXXX showing low vs. high propensity to @entity3 sensitization.

answer: @entity0


abstract: Basal plasma ACTH(1-39) concentrations are elevated in long-term @entity2 (LTH) fetal @entity4 . This study was designed to determine whether the expression of genes regulating @entity3 biosynthesis was altered after LTH. Pregnant ewes were maintained at high altitude (3,820 m) from day 30 of gestation to near term, when the animals were transported to the laboratory. Reduced @entity8 was maintained by @entity5 infusion through a maternal tracheal catheter. On days 137-141, fetal adrenal glands were collected from LTH and normoxic control fetuses. Real-time PCR was used to quantify mRNA for steroidogenic acute regulatory protein, 17alpha-hydroxylase ( @entity11 ), 21-hydroxylase (CYP21), @entity0 side-chain cleavage ( @entity12 ), @entity6 dehydrogenase type II (HSD3B2), and the @entity10 . We analyzed mRNA by slot-blot hybridization and also quantified mRNA for transcription factors necessary for adrenocortical development by quantitative real-time PCR: @entity13 and @entity9 , @entity1 congenital, critical region on the X chromosome (DAX-1). Protein was quantified by Western blot analysis. Adrenal mRNAs for @entity11 , @entity12 , and the @entity10 were significantly reduced in LTH fetal @entity4 compared with levels shown in controls. Similarly, @entity12 protein and @entity11 protein were reduced in the LTH group. CYP21, steroidogenic acute regulatory protein, @entity13 , and DAX-1 expressions were not altered in response to LTH. We conclude that expression of two key steroidogenic enzymes ( @entity11 , @entity12 ) regulating @entity3 biosynthesis and the @entity10 is lower in response to LTH. This likely represents an adaptive response to LTH, to prevent excessive @entity3 production that would restrict fetal growth and potentially induce @entity7 .

title: Long-term @entity2 represses the expression of key genes regulating XXXX biosynthesis in the near-term ovine fetus.

answer: @entity3


abstract: The combination of sunitinb (37.5 mg orally daily) + @entity9 (90 mg/m intravenously on days 1, 8, 15 every 4 weeks) was examined in @entity0 with advanced esophageal or gastroesophageal junction @entity1 , and progression-free survival (PFS) was compared to that of historical controls. The end points included response rate, overall survival, and @entity2 . Twenty-eight @entity0 were enrolled at six centers. Median age was 59.5 years. The 24-week PFS rate was 25% (90% confidence interval [CI], 12-42%). Three (11%) of 23 evaluable @entity0 had a response (1 complete response and 2 partial response) (90% CI, 3-25%). Median overall survival was 228 days (90% CI, 140-283 days). Grade 3/4 @entity2 included @entity11 / @entity10 (25%), @entity6 (18%), @entity8 (11%), and @entity7 (11%). There were four grade 5 @entity2 including upper @entity5 (n = 2), @entity4 (n = 1), and unexplained @entity3 (n = 1). In our study, we found that @entity12 + @entity9 in @entity0 with advanced esophageal or gastroesophageal junction @entity1 had a 24-week PFS no better than the PFS of historical controls. The combination also had a high rate of serious @entity2 and will not be pursued.

title: @entity12 plus @entity9 in XXXX with advanced esophageal cancer: a phase II study from the Hoosier Oncology Group.

answer: @entity0


abstract: BACKGROUND: Sensorineural complications of stapes surgery are rare but potentially serious. Imaging is usually performed to identify an underlying cause, such as excessive intravestibular penetration of the prosthesis or pneumolabyrinth suggesting perilymphatic @entity1 . Unfortunately, there is very little data in an unselected series of uneventful @entity0 .The aim of this study was to analyze the depth of prosthesis penetration within the vestibule and the rate of pneumolabyrinth the day or the day after the procedure by performing a cone beam computed tomography of the temporal bone in a cohort of unselected @entity0 , and to correlate imaging findings to clinical outcome. METHODS: A prospective monocentric study was conducted in a tertiary referral medical center. A cone beam computed tomography was performed in 80 consecutive @entity0 having undergone stapes surgery for @entity2 , the day or the day after the procedure. Penetration length and location of the prosthesis within the vestibule, as well as presence or absence of a pneumolabyrinth, were recorded, and compared with clinical data (vertigo, nystagmus, hearing measurement). RESULTS: Pneumolabyrinth was found in 15% of the @entity0 . The mean penetration length of the prosthesis within the vestibule was 1mm (0-1.9mm). No serious complication occurred during the study period. No correlations were found when comparing imaging findings to clinical outcome. CONCLUSION: Our results do not support empirically insights into detrimental effects of postoperative pneumolabyrinth or too long prosthesis after stapes surgery. Further studies are needed to better understand the causes of postoperative complications of stapes surgery.

title: Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for XXXX With Correlation to Audiovestibular Outcome.

answer: @entity2


abstract: Discs containing the @entity5 compound @entity6 at various concentrations may be useful in differentiating the following closely related species belonging to the genus Bacillus, viz. @entity0 , @entity2 and @entity4 ; @entity3 and B. macerans; together with @entity1 and its subspecies @entity1 . mycoides. At concentrations of 10 micrograms O129, the ATCC type strain of @entity0 was resistant whereas @entity2 and @entity4 were sensitive. However, @entity0 was sensitive to O129 at 150 micrograms. Similar reactions differentiated the ATCC type strains of @entity3 and B. macerans. The ATCC type strain of @entity1 was resistant to O129 at both 150 micrograms and 10 micrograms, but its subspecies @entity1 . mycoides (ATCC 28) was partially sensitive at 150 micrograms concentration. When clinical isolates of @entity1 . mycoides were subsequently tested, this partial sensitivity was found to be a variable characteristic.

title: Sensitivity of aerobic spore-forming species of the genus Bacillus to the XXXX compound O129.

answer: @entity5


abstract: BACKGROUND: @entity2 ( @entity2 ) is characterized by senile plaques, extracellular deposits composed primarily of @entity7 ( @entity7 ), and @entity6 , which are abnormal intracellular inclusions containing hyperphosphorylated tau. The amyloid cascade hypothesis posits that the deposition of @entity7 in the brain parenchyma initiates a sequence of events that leads to @entity3 . However, the molecular process by which the extracellular accumulation of @entity7 peptides promotes intracellular pathologic changes in tau filaments remains unclear. To elucidate this process, we presumed that astrocytes might trigger neuronal reactions, leading to tau phosphorylation. In this study, we examined @entity2 pathology from the perspective of the astrocyte-neuron interaction. RESULTS: A cytokine-array analysis revealed that @entity7 stimulates astrocytes to release several chemical mediators that are primarily related to @entity1 and cell adhesion. Among those mediators, @entity5 ( @entity5 ) was highly upregulated. In @entity2 brains, the expression of @entity5 was found to be increased by western blot analysis, and increased expression of @entity5 was observed in astrocytes via fluorescence microscopy. In addition, we reproduced the increase in @entity5 after treatment with @entity7 using @entity0 @entity4 cell lines and found that @entity5 was expressed via calcineurin. In @entity2 brains, the activated forms of calcineurin were found to be increased by western blot analysis, and increased expression of calcineurin was observed in astrocytes via fluorescence microscopy. When Ser9 of glycogen synthase kinase-3b ( @entity8 ) is phosphorylated, @entity8 is controlled and tau phosphorylation is suppressed. @entity7 suppresses the phosphorylation of @entity8 , leading to tau phosphorylation. In this study, we found that IGF-   suppressed tau phosphorylation induced by @entity7 , although @entity5 inhibited this property of IGF-  . As a result, @entity5 contributed to tau phosphorylation and cell death induced by @entity7 . CONCLUSIONS: Our study suggested that calcineurin in astrocytes was activated by @entity7 , leading to @entity5 release. We further demonstrated that @entity5 produced by astrocytes induced tau phosphorylation in neurons. Our study provides novel insights into the role of astrocytes in the induction of tau phosphorylation and suggests that @entity5 could be an important link between @entity7 and tau pathology and an important therapeutic target.

title: The participation of @entity5 released by astrocytes in the pathology of XXXX .

answer: @entity2


abstract: PURPOSE: To determine if contrast-enhanced electron beam CT (EBCT) can detect areas of acute @entity1 , and if pharmacological stress testing improves the diagnostic accuracy of EBCT. MATERIAL AND METHODS: We injected 0.5 ml/kg and 1.0 ml/kg b.w. of @entity3 at a rate of 4 ml/s into the right atrium of 5 ventilated female minipigs at rest and after occlusion of the left anterior descending (LAD) coronary artery. Both ventricles were examined at six short axis levels with an EBCT unit. Myocardial perfusion was calculated from the time-density curves of four left ventricular myocardial segments and the aorta. We also tested the effect of the contrast agent on myocardial density after i.v. administration of 0.6 mg/kg @entity2 before and after @entity0 . RESULTS: At rest, the contrast agent increased myocardial density by 28+/-2 HU, corresponding to a myocardial perfusion estimate of 67+/-7 ml/min/100 g. After @entity2 , myocardial density increased by 29+/-4 HU. Following occlusion of the LAD, anteroseptal myocardium displayed 10+/-4 HU density increase. The area of non-enhancement corresponded to ischemic myocardium in stained pathologic sections. CONCLUSION: Contrast-enhanced stress EBCT can be used to detect areas of @entity1 , and EBCT stress perfusion imaging may be necessary to consistently differentiate ischemic from non-ischemic myocardial tissue.

title: Detection of XXXX by electron beam CT. Experimental studies.

answer: @entity1


abstract: Evidence suggests that @entity1 could be a preferential energy substrate transferred from astrocytes to neurons. Such a process implies the presence of specific @entity2 transporters on both cell types. Expression of @entity4 and @entity5 , two isoforms of the @entity2 transporter (MCT) family, was studied in enriched cultures of @entity0 cortical astrocytes or neurons. It was observed that, at both the mRNA and the protein levels, astrocytes strongly expressed @entity4 but had very little if any @entity5 . By contrast, neurons had high amounts of @entity5 mRNA, although @entity4 mRNA was also detected. Double immunofluorescent labelings with appropriate markers confirmed the cell-specific preference in the expression of @entity4 and @entity5 , but they revealed that a subset of neurons expresses low to moderate levels of @entity4 . Parallel immunocytochemical stainings of cultured neurons with the presynaptic marker @entity3 showed that @entity5 expression is correlated with synaptic development. Although @entity5 and @entity3 were not colocalized, their distribution was similar, and they were often closely apposed, suggesting that @entity5 could be associated with postsynaptic terminals. Interaction between astrocytes and neurons, as occurring in layered cultures, did not modify the levels of @entity4 and @entity5 expression or their distribution and cell-specific preference under the conditions used. However, a close apposition between neurites and @entity4 -expressing astrocytic processes was apparent and developed as cultures evolved. In addition to providing an extensive description of MCT distribution in cultured cells, our data underscore the potential of such preparations for future studies on the regulation of MCT expression.

title: Cell-specific expression pattern of XXXX transporters in astrocytes and neurons observed in different @entity0 brain cortical cell cultures.

answer: @entity2


abstract: The subrenal capsule assay (SRCA) is used in clinical oncology to assess the sensitivity of individual @entity1 to various anticancer agents and their combinations. Mitotic indices reflect @entity1 cell proliferation and have prognostic value in @entity6 , including @entity3 . We combined the two tests (SRCA, mitotic index) by evaluating the numbers of mitotic figures per square millimeter of neoplastic epithelium (M/V) in @entity5 -embedded @entity1 samples after SRCA. The M/V index was compared with the @entity1 size measurement (dTS), which is used in conventional SRCA to predict the drug response. Histology examination showed insignificant changes in the size of @entity1 transplants due to host reaction but disclosed a number of potential errors in the use of dTS to evaluate transplant growth and drug effects. In our series of 62 @entity0 with advanced @entity3 the M/V value was superior to the dTS in explaining the clinical response after 6 months as assessed at second-look laparotomy. @entity0 showing no response had significantly higher M/V values than did those displaying complete or partial responses (P < 0.033). The use of 6 mitotic figures/ @entity4 as a limit differentiating responders from nonresponders resulted in an overall predictive accuracy of 79% in the logistic regression analysis. In comparison to the FIGO stage, @entity2 size, and the dTS, the M/V value obtained for the cytostatic combination given to the @entity0 was the single most significant factor predicting the 6-month clinical response. The results indicate that the combined use of the M/V index and SRCA is a promising new approach to prediction of the drug response in @entity3 .

title: Mitotic index in the subrenal capsule assay as an indicator of the XXXX .

answer: @entity3


abstract: OBJECTIVE: To compare endocrine profiles and IVF outcomes after using @entity2 agonists ( @entity5 ) to trigger final oocyte maturation in @entity0 with @entity3 ( @entity3 ) with other hyper-responders. DESIGN: Retrospective cohort study. SETTING: @entity4 center. @entity0 (S): Forty @entity0 with @entity3 and 74 hyper-responders without @entity3 . INTERVENTION(S): @entity5 trigger. MAIN OUTCOME MEASURE(S): Number of oocytes. RESULT(S): Serum E2, LH, and P levels on the day of @entity5 trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No @entity0 developed @entity1 ( @entity1 ). CONCLUSION(S): The similar post- @entity5 trigger hormone profiles and mature oocyte yield support the routine use of @entity5 trigger to prevent @entity1 in @entity0 with @entity3 .

title: Use of gonadotropin-releasing hormone agonist trigger during in  vitro fertilization is associated with similar endocrine profiles and oocyte measures in XXXX with and without @entity3 .

answer: @entity0