abstract: In addition to immunomodulatory and cytokine-modulatory properties, @entity15 has antiangiogenic activity. It has been investigated in a number of @entity2 including @entity10 , @entity13 , @entity3 , @entity16 , @entity9 , @entity0 , and @entity4 . Its role has been best explored in @entity10 , where, at daily doses of 100 to 800 mg, it is remarkably active, causing clinically meaningful responses in one-third of extensively pretreated @entity1 and in over half of @entity1 treated early in the course of the disease. It also acts synergistically with corticosteroids and chemotherapy in @entity10 . @entity15 produces improvement of cytopenias characteristic of @entity13 , resulting in the reduction or elimination of transfusion dependence in some @entity1 . Responses have also been seen in one-third of @entity1 with @entity16 , in a small proportion of @entity1 with @entity9 and high grade @entity3 and, in combination with @entity14 , in some @entity1 with @entity4 . @entity15 is being investigated currently in a number of clinical trials for @entity2 . Drowsiness, @entity6 and @entity8 are common adverse effects seen in 75% of @entity1 . Symptoms of @entity11 and @entity12 are seen in 30%. A minority of @entity1 experience @entity7 and @entity5 phenomena. Despite the high frequency of adverse effects, those severe enough to necessitate cessation of therapy are seen in only 10 to 15% of @entity1 . A therapeutic trial of @entity15 should be considered in all @entity1 with @entity10 who are unresponsive to or relapse after standard therapy. In other @entity2 , the most appropriate way to use the drug is in the setting of well designed clinical trials. In the absence of access to such studies, @entity15 could be considered singly or in combination with standard therapy in @entity1 with no meaningful therapeutic options.

title: XXXX in @entity2 : potential uses and limitations.

answer: @entity15


abstract: Since the phospholipase B (PLB) was reported as a deacylase of both lecithin and lysolecithin yielding @entity3 and @entity8 (GPC), there was a question as to whether it is a single enzyme or a mixture of a phospholipase A2 (PLA2) and a lysophospholipase (LPL). We purified the PLB in @entity6 and showed that it catalyzed deacylation of sn-1 and sn-2 @entity3 of 1,2-diacylphospholipids and also sn-1 or sn-2 @entity3 of 1- or 2-monoacylphospholipids (lysophospholipids). Further, it also has a monoacyllipase activity. The purified PLB is a glycoprotein with m.w. of 91,300. The sugar moiety is M9 only and the protein moiety consists of 603 @entity2 . PLB, different from PLA2, shows other enzymatic activities, such as transacylase, lipase and acylesterase. PLB activity is influenced by various substances, e.g. detergents, @entity7 , @entity5 , @entity1 , and endogenous protease. Therefore, PLB might have broader roles than PLA2 in vivo. The database shows an extensive sequence similarity between @entity6 PLB and fungal PLB, cPLA2 and patatin, suggesting a homologous relationship. The catalytic triad of cPLA2, Ser, @entity4 and @entity0 , is also present in @entity6 PLB. Other related PLBs, PLB/Lipases are discussed.

title: Reminiscence of phospholipase B in XXXX .

answer: @entity6


abstract: PURPOSE: To study the incidence, clinical features and outcome of @entity1 with special reference to long-term @entity2 after Snip-punctoplasty and curettage. METHODS: Single center, retrospective, telephonic questionnaire study. The medical records of @entity0 who visited Orbit and Oculoplasty clinic, Tertiary Eye Hospital, India from 01 July 2011 to 31 June 2012 were analyzed. Records of the @entity0 with @entity1 were reviewed for clinical profile and management. Post-surgical @entity0 thus identified were telephonically contacted in December 2012. Questionnaire was used to assess the @entity2 . Symptomatic @entity0 were given clinic appointment, reassessed and managed. RESULTS: 2245 @entity0 visited Orbit and Oculoplasty clinic during the study period. The incidence of @entity1 was 1.4% (31 @entity0 ). The median age of the @entity0 with @entity1 was 65  years (range, 14-80  yrs). Sixteen @entity0 were male. All cases were unilateral and four eyes showed both upper and lower canalicular involvement. The commonest clinical presentations were pus or concretion from punctum (28), mucous discharge (23), @entity2 (18) and conjunctival injection (18). Three snip punctoplasty and canalicular curettage was performed in 30 of these @entity0 . Twenty of the 25 available culture results were positive and streptococcus species was the most common isolated organism. Records revealed that five (22%) of these @entity0 had persistence of symptoms. Twenty-three @entity0 could be contacted telephonically. The median follow-up of these @entity0 was 11  months. On telephonic communication we found that two (8.7%) @entity0 had @entity2 . @entity2 score in these @entity0 was three and one respectively. CONCLUSIONS: Incidence of @entity1 was 1.4%. Most common isolate was streptococcus species. Snip-punctoplasty and curettage is a safe and efficacious modality of treatment of @entity1 . @entity2 occurred in 8.7% @entity0 .

title: Primary @entity1 : The incidence, clinical features, outcome and long-term XXXX after snip-punctoplasty and curettage.

answer: @entity2


abstract: The functional properties of spontaneous, glutamatergic EPSCs and non- @entity2 receptors in AII amacrine cells were studied in whole cells and patches from slices of the @entity0 retina using single and dual electrode voltage clamp recording. Pharmacological analysis verified that the EPSCs (Erev approximately 0 mV) were mediated exclusively by @entity1 -type receptors. EPSCs displayed a wide range of waveforms, ranging from simple monophasic events to more complex multiphasic events. Amplitude distributions of EPSCs were moderately skewed towards larger amplitudes (modal peak 23 pA). Interevent interval histograms were best fitted with a double exponential function. Monophasic, monotonically rising EPSCs displayed very fast kinetics with an average 10-90 % rise time of approximately 340 micro s and a decay phase well fitted by a single exponential (taudecay approximately 760 micro s). The specific @entity1 receptor modulator @entity4 markedly slowed the decay phase of spontaneous EPSCs (taudecay approximately 3 ms). An increase in temperature decreased both 10-90 % rise time and taudecay with Q10 values of 1.3 and 1.5, respectively. The decay kinetics were slower at positive membrane potentials compared to negative membrane potentials (205 mV/e-fold change in taudecay). Step depolarization of individual presynaptic rod bipolar cells or OFF-cone bipolar cells evoked transient, CNQX-sensitive responses in AII amacrine cells with average peak amplitudes of approximately 330 pA. Ultrafast application of brief (approximately 1 ms) or long (approximately 500 ms) pulses of @entity3 to outside-out patches evoked strongly desensitizing responses with very fast deactivation and desensitization kinetics, well fitted by single (taudecay approximately 1.1 ms) and double exponential (tau1 approximately 3.5 ms; tau2 approximately 21 ms) functions, respectively. Double-pulse experiments indicated fast recovery from desensitization (tau approximately 12.4 ms). Our results indicate that spontaneous, @entity1 receptor-mediated EPSCs in AII amacrine cells have very fast, voltage-dependent kinetics that can be well accounted for by the kinetic properties of the @entity1 receptors themselves

title: Functional properties of spontaneous EPSCs and non- @entity2 receptors in rod amacrine (AII) cells in the XXXX retina.

answer: @entity0


abstract: INTRODUCTION: Pulmonary metastases occur in up to 25% of @entity2 ( @entity2 ) @entity0 . Many studies have reported that pulmonary metastasectomy might increase 5-year survival of these @entity0 . The aim of this study was to describe our experience with pulmonary metastasectomy for metastatic @entity2 and to explore the prognostic value of serum @entity3 ( @entity3 ) and other factors. METHODS: Between June 2002 and December 2013, the clinicopathological data of 88 @entity0 who underwent resection of pulmonary metastases from @entity2 were retrospectively reviewed and analyzed. Clinical, investigative and operative data were prospectively collected. Overall survival (OS) was calculated from resection of pulmonary metastases to death. RESULTS: There were 58 @entity0 and 30 @entity0 in this study, and their median age was 55 (range 31 to 85). Video-assisted thoracoscopic surgery (VATS) was performed in 59 cases (78%) and 29 @entity0 (19%) underwent thoracotomy. Lung wedge resection and pulmonary lobectomy were performed in 52 (59.1%) and 36 @entity0 (40.9%), respectively. Preoperative elevated @entity3 was present in 8 (9.1%) @entity0 . After a median follow-up duration of 44 months, the cumulative 5-year survival was 45.4% and the median overall survival (OS) was 57.8 months. A significantly longer survival was observed in @entity0 with normal preoperative @entity3 level compared with those with @entity3 level exceeding 10mg/L (62.6 months vs. 34.3 months, P=0.011). In multivariate analysis, preoperative @entity3 level was found to be independent significant prognostic factors for survival. CONCLUSIONS: Pulmonary resection of metastatic @entity2 might offer a chance to prolong survival including those @entity0 with extrapulmonary @entity1 . Preoperative serum @entity3 level was identified as prognosis-related factor for surgery.

title: XXXX ( @entity3 ) as a prognostic factor for @entity2 after surgical resection of pulmonary metastases.

answer: @entity3


abstract: Flow and stresses induced by blood flow acting on the blood cellular constituents can be represented to a certain extent by a continuum mechanics approach down to the order of the   m level. However, the molecular effects of, e.g., adhesion/aggregation bonds of @entity3 can be on the order of nm. The coupling of the disparate length and timescales between such molecular levels and macroscopic transport represents a major computational challenge. To address this challenge, a multiscale numerical approach based on discrete particle dynamics (DPD) methodology derived from @entity0 ( @entity0 ) principles is proposed. The feasibility of the approach was firstly tested for its ability to simulate viscous flow conditions. Simulations were conducted in low Reynolds numbers flows (Re = 25-33) through constricted tubes representing blood vessels with various degrees of @entity1 . Multiple discrete particles interacting with each other were simulated, with 1.24-1.36 million particles representing the flow domain and 0.4 million particles representing the vessel wall. The computation was carried out on the massive parallel supercomputer NY BlueGene/L employing NAMD-a parallel @entity0 package for @entity2 ( @entity2 ). Typical recirculation zones were formed distal to the stenoses. The velocity profiles and recirculation zones were in excellent agreement with @entity4 ( @entity4 ) 3D Navier-Stokes viscous fluid flow simulations and with classic numerical and experimental results by YC Fung in constricted tubes. This feasibility analysis demonstrates the potential of a methodology that widely departs from a continuum approach to simulate multiscale phenomena such as flow induced @entity3 .

title: Viscous flow simulation in a XXXX model using discrete particle dynamics: a comparison between DPD and @entity4 .

answer: @entity1


abstract: UNASSIGNED: Introduction. @entity1 ( @entity1 ) is a constellation of clinical and radiologic findings. Fluctuations in blood pressure, @entity3 , and reversible brain MRI findings mainly in posterior cerebral white matter are the main manifestations. @entity1 has been associated with multiple conditions such as @entity5 , pregnancy, organ transplant, and @entity10 ( @entity10 ). Case Presentation. A 22-year-old @entity0 with history of @entity8 complicated with @entity4 secondary to @entity9 class IV presented with recurrent @entity3 and uncontrolled @entity2 . She was found to have @entity6 and @entity7 . Repeat kidney biopsy showed diffuse endocapillary and extracapillary proliferative and membranous @entity9 (ISN-RPS class IV-G+V) and endothelial swelling secondary to severe @entity2 but no evidence of @entity10 . Brain MRI showed reversible @entity1 that resolved after controlling the blood pressure, making @entity1 the diagnosis. Conclusion. @entity1 is an important entity that must be recognized and treated early due to the potential reversibility in the early stages. Physicians must have high suspicion for these unusual presentations. We present a case where performing kidney biopsy clinched the diagnosis in our @entity0 with multiple confounding factors.

title: @entity6 , Recurrent @entity3 , and @entity7 in a Young @entity0 with XXXX : A Diagnostic Dilemma.

answer: @entity9


abstract: UNASSIGNED: The removal of @entity4 from gaseous emissions was studied using two biotrickling filters (BTF1 and BTF2) packed with @entity2 foam. Two different inoculum sources were used: a pure culture of @entity3 sp. BOE200 (BTF1) and activated sludge from a municipal wastewater treatment plant (BTF2). The bioreactors were operated at inlet loads (ILs) of 130 and 195gm(-3)hour(-1) and at an empty bed residence time (EBRT) of 12.5s. Under an IL of    130gm(-3)hour(-1), BTF1 presented higher elimination capacities (ECs) than BTF2, with average values of 106  7 and 68  8gm(-3)hour(-1), respectively. However, differences in ECs between BTFs were decreased by reducing the irrigation intervals from 1min every 12min to 1min every 2hours in BTF2. Average values of EC were 111  25 and 90  7gm(-3)hour(-1) for BTF1 and BTF2, respectively, when working at an IL of    195gm(-3)hour(-1). Microbial analysis revealed a significant shift in the microbial community of BTF1 inoculated with @entity3 sp. BOE200. At the end of the experiment, the species Microbacterium sp., Chryseobacterium sp., Acinetobacter sp., @entity3 sp. and Mycobacterium sp. were detected. In BTF2 inoculated with activated sludge, the denaturing gradient gel electrophoresis (DGGE) technique showed a diverse microbial community including species that was able to use @entity4 as its @entity0 source, such as @entity1 and @entity3 as representative species. Although BTF1 inoculated with @entity3 sp. BOE200 and higher gas velocity (probably greater gas/liquid mass transfer rate) showed a slight improvement in performance, the use of activated sludge as inoculum seems to be a more feasible option for the industrial application of this technology.

title: Removal of XXXX gaseous emissions by biotrickling filtration packed with @entity2 foam.

answer: @entity4


abstract: BACKGROUND: There is limited information on the validity of magnetic resonance imaging (MRI) in detection of @entity1 . The purpose of this study was to examine the measurement properties of noncontrasted MRI in diagnosis of @entity1 using arthroscopic surgery as the "gold standard." MATERIALS AND METHODS: Prospectively collected surgical data of @entity0 with @entity5 or @entity3 cuff tear, with @entity1 (study group) or without @entity1 (control group), were reviewed. MRI reports of radiologists with fellowship training in musculoskeletal imaging were retrospectively reviewed and compared with surgical findings. RESULTS: Data of 183 (130 study and 53 control) @entity0 (73 @entity0 [40%], 110 @entity0 [60%]; mean age,  62 years [standard deviation,  9]) who had undergone arthroscopic @entity3 cuff-related surgery during a period of 11  years were used for analysis. Sensitivity and specificity of MRI for detection of full @entity4 were 0.54 and 0.98, respectively. Sensitivity and specificity were 0.27 and 0.86 for partial @entity4 , respectively. For @entity2 subluxation or dislocation, sensitivity was 1.00 and specificity was 0.83. The areas under the receiver operating characteristic curves, which quantify the overall accuracy of the tests, were 0.57, 0.75, and 0.92 for partial tear, full tear, and instability of the @entity2 tendon, respectively. CONCLUSIONS: Noncontrasted MRI has a low sensitivity and high specificity for detection of full-thickness @entity4 . It is highly sensitive for diagnosis of instability of the long head of the @entity2 . However, its usefulness for diagnosis of partial @entity4 remains limited.

title: Accuracy of magnetic resonance imaging in detecting @entity2 pathology in XXXX with @entity3 cuff disorders: comparison with arthroscopy.

answer: @entity0


abstract: The effects in the brain of selective @entity3 receptor modulators (SERMs) such as @entity4 and @entity5 have not yet been fully elucidated. Based upon the hypothesis that @entity6 ( @entity6 )- @entity2 hormone interactions are important in mood regulation, we have compared six SERMs ( @entity4 , @entity5 , @entity9 , NNC 45-0781, NNC 45-0320, NNC 45-1506) with @entity1 (E(2)) in terms of their ability to regulate mRNA levels of @entity3 receptor (ER)alpha, @entity8 , @entity6 (1A) receptor, and @entity6 reuptake transporter (SERT) in the midbrain, amygdala, and hypothalamus of ovariectomized (OVX) @entity0 . Female @entity0 (n = 6/group, 8 groups total) were OVX and allowed to recover for 2 weeks. During the third post-OVX week, @entity0 were injected subcutaneously with E(2) (0.1 mg/kg) or one of the SERMs (5 mg/kg) once per day for 7 days. Twenty-four hours after the last injection, tissue was collected for the determination of mRNA levels by ribonuclease protection assay (RPA). E(2) treatment significantly decreased mRNA levels for @entity7 , @entity8 , and SERT in midbrain and @entity7 in hypothalamus. @entity4 increased @entity8 mRNA levels in hypothalamus, while @entity5 increased @entity8 mRNA levels in amygdala. NNC 45-0320 decreased @entity7 mRNA in hypothalamus and decreased @entity8 mRNA in amygdala. These results suggest that while SERMs are not full @entity3 receptor agonists in the brain, the agonist/antagonist profiles for individual SERMs may differ among brain areas. This raises the possibility of developing new SERMs for selective functions in specific brain areas.

title: Selective @entity3 receptor modulator effects in the XXXX brain.

answer: @entity0


abstract: OBJECTIVES: We conducted a multicenter retrospective study to determine the results of treatment for @entity3 in solid organ transplant recipients. METHODS: A retrospective analysis of all @entity0 diagnosed with @entity3 after organ transplantation at five centers was conducted. Data were obtained by chart review and a multipoint data sheet was used to abstract the data from the @entity0 charts. RESULTS: Eighteen cases of @entity3 were identified from six institutions. Most (84%) of the @entity1 were clinically localized at the time of diagnosis. Nine (50%) of 18 @entity0 underwent radical prostatectomy, which was the predominant mode of treatment. Overall survival at a mean follow-up of 32 months was 66%, with a @entity1 specific mortality of 16%. Mortality was 13% for the 15 @entity0 with @entity2 and 33% for the 3 @entity0 with metastatic disease at the time of diagnosis. CONCLUSIONS: Most of the @entity0 with @entity3 being detected after solid organ transplantation were diagnosed with @entity2 . Aggressive therapeutic intervention as in the general (nontransplant) population yields good results and should be pursued. Diligent surveillance for @entity3 in this population using periodic digital rectal examination, serum @entity4 , and prostate needle biopsy as needed will ensure earlier @entity1 detection and allow for definitive therapeutic intervention.

title: XXXX in the post-transplant population. Urologic Society for Transplantation and Vascular Surgery.

answer: @entity3


abstract: UNASSIGNED: Dendritic cells (DCs) are powerful APCs that can induce Ag-specific adaptive immune responses and are increasingly recognized as important players in innate immunity to both @entity1 . Interestingly, although there are multiple described @entity4 , DC @entity1 are rarely observed in @entity0 . Whether this is linked to the immunogenic potential of DCs, which might render them uniquely susceptible to immune control upon neoplastic transformation, has not been fully investigated. To address the issue, we generated a genetically engineered @entity2 model in which expression of Cre recombinase driven by the C-type lectin domain family 9, member a ( @entity8 ) locus causes expression of the Kirsten @entity3 sarcoma viral oncogene homolog (Kras)( @entity6 ) oncogenic driver and deletion of the @entity1 suppressor @entity7 within developing and differentiated DCs. We show that these @entity8 (Kras- @entity6 ) @entity2 rapidly succumb from disease and display massive accumulation of transformed DCs in multiple organs. In bone marrow chimeras, the development of DC @entity1 could be induced by a small number of transformed cells and was not prevented by the presence of untransformed DCs. Notably, activation of transformed DCs did not happen spontaneously but could be induced upon stimulation. Although @entity8 (Kras- @entity6 ) @entity2 showed altered thymic T cell development, @entity5 cells were largely unaffected during DC @entity1 development. Interestingly, transformed DCs were rejected upon adoptive transfer into wild-type but not lymphocyte-deficient @entity2 , indicating that immunological control of DC @entity1 is in principle possible but does not occur during spontaneous generation in @entity8 (Kras- @entity6 ) @entity2 . Our findings suggest that neoplastic transformation of DCs does not by default induce anti- @entity1 immunity and can develop unhindered by immunological barriers.

title: Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in XXXX .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) is a noninvasive technique that can be used to assess the integrity of cerebral tissue. The purpose of this study was to assess DTI measurements in the hippocampal formation (HF) and to investigate the role of DTI in lateralizing the @entity2 focus in @entity3 ( @entity3 ). METHODS: We evaluated 12 @entity0 with unilateral @entity3 and 14 healthy subjects. We collected diffusion-weighted images along six different directions with a b value of 1000 s/mm(2), as well as an image acquired without diffusion weighting (b = 0 s/mm(2)). A 1.5-T imager was used to acquire 17 (3-mm) coronal sections covering the temporal lobes. We compared the mean diffusivity (trace D) and fractional anisotropy (FA) from symmetrical voxels by sampling the anterior HF bilaterally. We compared measurements with the EEG, high-resolution MR imaging, and clinical information. RESULTS: The @entity0 group had significantly increased diffusivity and decreased FA in the HF ipsilateral to the @entity2 focus, as compared with values in the contralateral HF. When compared with healthy subjects, @entity0 had significantly higher mean diffusivity in the ipsilateral HF; ipsilateral FA values were lower and did not reach statistical significance. Measurements in the contralateral HF did not show differences. Left-right and absolute diffusivity indices lateralized the abnormal HF in eight and five of 12 @entity0 , respectively. CONCLUSION: Abnormal DTI measurements and the epileptogenic HF are associated in unilateral @entity3 . This finding may reflect @entity1 and may aid in presurgical evaluation.

title: Diffusion tensor imaging of the hippocampal formation in XXXX .

answer: @entity3


abstract: The purpose of this study was to determine the role of the CD11b-dependent respiratory burst in neutrophil oxidant generation and activation, @entity5 ( @entity5 ) production, and @entity0 after @entity2 by using the monoclonal antibody M1/70 to block this pathway. Twelve male New Zealand White @entity1 were randomly assigned to a treatment group: M1/70 (n = 6), IgG isotype control (n = 3), or saline control (n = 3). After intravenous injection of the assigned agent under gas anesthesia, a standardized single- @entity3 was created in the right tibialis anterior, whereas the left tibialis anterior underwent a sham surgery. Blood-borne neutrophil oxidant generation and CD11b receptor density and plasma @entity5 levels were measured pre- and 24 h postinjury. Damage was assessed histologically at the @entity4 site by counting torn myofibers. M1/70 group demonstrated decreased blood-borne neutrophil oxidant generation (P < 0.05) and CD11b receptor density (P < 0.05), an increase in plasma @entity5 concentration (P < 0.01), and less torn myofibers (P < 0.01) compared with IgG isotype or saline control groups. These data indicate that 1). CD11b-dependent respiratory burst is a major source of oxidants produced by the neutrophil, and that treatment with M1/70 2). attenuates neutrophil activation status, 3). increases plasma @entity5 concentration, and 4). minimizes @entity0 24 h postmuscle @entity3 .

title: M1/70 attenuates blood-borne neutrophil oxidants, activation, and XXXX following @entity3 .

answer: @entity0


abstract: @entity5 , including @entity0 ( @entity0 ), are the most commonly induced @entity0 resulting from chemical carcinogen evaluation. Our objective was to image @entity0 using computed tomography. In a preliminary study using @entity1 with @entity3 ( @entity4 ) induced @entity0 , lesions smaller than 1.5 cm were difficult to identify by CT. Since @entity0 do not take up excess @entity2 whereas normal liver does accumulate @entity2 , we studied @entity2 as a CT contrast material. @entity6 was induced in 15 control @entity1 by subcutaneous injections of @entity2 dextran. A linear increase in @entity2 -loading dose produces a linear CT liver enhancement (r = 0.97): 68, 80, 84, 94, and 104 HU at 0, one, two, four, and six weeks, respectively. No loss of enhancement was noted ten weeks later. @entity1 hepatic tissue was chemically analyzed after a similar @entity2 -loading regimen. The @entity2 concentration (microgram/g hepatic tissue) progressively increased during the first four weeks of loading and remained stable for three weeks following @entity2 -loading. Four animals that had been given @entity4 and @entity2 were examined by CT scanning to detect small @entity0 . @entity2 -enhanced CT allowed the visualization of small lesions (less than 5 mm). Histopathologic sections confirmed a homogeneous pattern of @entity2 uptake in normal liver with a deficiency of @entity2 in @entity0 . We conclude that CT scanning following @entity2 -loading is a noninvasive method to detect small nodules and may provide a method to study the progression or regression of small liver nodules in rodents.

title: A CT technique to evaluate the development of carcinogen-induced @entity0 in the XXXX liver.

answer: @entity1


abstract: @entity1 ( @entity1 ) of marrow is a proven method of @entity3 ( @entity3 ) prophylaxis in allogeneic bone marrow transplantation (BMT). Nonetheless, @entity1 is associated with an increased risk of developing @entity2 ( @entity2 ). Between 1986 and 1998, 241 pediatric @entity0 at the University of Iowa underwent BMT using ex vivo @entity1 of marrow from mismatched related or matched unrelated donors. Additional @entity3 prophylaxis included antithymocyte globulin (ATG) or anti lymphocyte globulin (ALG) post transplant (in vivo @entity1 ). A total of 30 cases of @entity2 were identified based upon a combination of clinical, histological, and immunological features. Nearly all cases occurred within 3 months post BMT. A statistically significant increase in @entity2 incidence was noted for @entity0 treated with ATG vs ALG (33 vs 9%). While grade I-II acute @entity3 was more common in @entity0 receiving ATG vs ALG, no difference in grade III-IV @entity3 or overall survival was noted between the two groups. Assessment of immune recovery at various times post BMT revealed significantly fewer T cells in the ATG-treated group, suggesting the deleterious effect of ATG may be due to excessive depletion of donor-derived @entity4 -specific cytotoxic T cells. Thus, caution should be exercised in the use of anti-T-cell antibody therapy for additional @entity3 prophylaxis in the setting of @entity1 BMT.

title: Effect of in vivo lymphocyte-depleting strategies on development of @entity2 in XXXX post allogeneic bone marrow transplantation.

answer: @entity0


abstract: UNASSIGNED: The purpose of this study is to compare the effect of topical @entity6 and topical @entity3 on anterior chamber flare and @entity2 following @entity4 ( @entity4 ) surgery. This prospective study included 40 eyes of 40 @entity0 treated for @entity4 . Twenty-eight @entity0 underwent scleral buckling and 12 @entity0 underwent 20-gauge pars plana vitrectomy ( @entity5 ). For each surgical procedure, @entity0 were postoperatively randomly divided into two groups: the first group received topical @entity7 0.1  % four times daily for 28  days; the second group received topical @entity6 0.1  % three times daily for 28  days. The inflammatory reaction in the anterior chamber was measured with laser flare photometry preoperatively and 1, 7, 14, 28, and 90  days postoperatively. @entity1 level was evaluated with Scott's visual analog scale at day 1, 7, 14, and 28 postoperatively. For @entity0 treated with scleral buckling, there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p  =  0.096), day 7 (p  =  0.435), day 14 (p  =  0.510), day 28 (p  =  0.583), and day 90 (p  =  0.423). The group who received @entity6 had significantly lower @entity1 score at days 7, 14, and 28 (p  =  0.048, p  =  0.017, and p  =  0.028, respectively). For @entity0 treated with @entity5 , there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p  =  0.400), day 7 (p  =  0.728), day 14 (p  =  0.843), day 28 (p  =  0.939), and day 90 (p  =  0.568). @entity0 who received @entity6 had significantly lower @entity1 score at days 7, 14, and 28 (p  =  0.032, p  =  0.030, and p  =  0.023, respectively). Topical @entity6 seems to be as potent as topical @entity3 in managing postoperative inflammatory response induced by surgery for @entity4 with better analgesic effect. Both of them are consequences of blood-aqueous barrier and blood-retinal barrier breakdown.

title: Comparative effect of topical @entity6 and topical @entity3 on anterior chamber flare and XXXX following @entity4 surgery.

answer: @entity2


abstract: PURPOSE: To evaluate the safety and efficacy of a new mesh in the pre-peritoneal repair of @entity2 . METHODS: We randomly divided 120 @entity0 undergoing pre-peritoneal repair into 2 groups between March 2012 and December 2013. The @entity0 were randomized to receive the Swing mesh (n=60; study group) or the Modified Kugel mesh (n=60; control group). The primary end point of this study was to compare postoperative groin @entity1 of the two groups. Complications, recurrence and analgesic use were also recorded. RESULTS: There were no recurrent cases in either group throughout the study period. There was no significant difference between the groups with respect to @entity3 . The VAS of early @entity4 was 1.32  1.69 in study group and 1.52  1.93 in control group, with the difference being not statistically significant (p = 0.547). Concerning @entity5 , no remarkable statistically significant difference was observed between the two groups at 3-month, 6-month, 12- and 18-month follow-up period. CONCLUSION: Swing mesh can be safely and effectively used in @entity2 with the same advantage compared to the Modified Kugel mesh.

title: Swing mesh versus Modified Kugel mesh for primary XXXX . A prospective randomized clinical trial.

answer: @entity2


abstract: BACKGROUND: @entity4 inhibitors (DPP4Is) are drugs for the treatment of @entity1 ( @entity1 ). There is increasing evidence that DPP4Is may result in suppression of the immune system and may increase the risk of infections such as @entity2 . Aim of this study was to evaluate the association between the use of DPP4Is and the risk of @entity2 in a population-based study. METHODS: We conducted a population-based cohort study using data from the world's largest primary care database, the UK Clinical Practice Research Datalink (CPRD). We selected all users of @entity3 ( @entity3 ), including DPP4Is, between 2007 and 2012. To each NIAD user, we matched randomly selected non-users. The NIAD user's first prescription defined the index date, which was then assigned to the matched non-users. @entity0 were followed from their first prescription until end of data collection or the first event of @entity2 , whichever came first. Cox regression analysis estimated the association between @entity2 and current use of DPP4Is versus 1) current use of other @entity3 and 2) non-users. DPP4I use was then stratified to daily and cumulative dose. Analyses were statistically adjusted for age, sex, lifestyle factors and comorbidities and concomitant use of various other drugs. RESULTS: Risk of @entity2 was not increased with current DPP4I use versus use of other @entity3 , adjusted Hazard Ratio (HR) 0.70; 95% Confidence Interval (CI) 0.55-0.91. Also higher cumulative doses or daily doses did not further increase risk of @entity2 . CONCLUSION: We found no increased risk of @entity2 in @entity1 @entity0 using DPP4Is compared to @entity1 @entity0 using other @entity3 . Our finding is in line with direct and indirect evidence from observational studies and RCTs. There is probably no need to avoid prescribing of DPP4Is to elderly @entity0 who are at risk of @entity2 .

title: Use of XXXX Inhibitors and the Risk of Pneumonia: A Population-Based Cohort Study.

answer: @entity4


abstract: PURPOSE: The purpose of this study was to develop an instrument that measures response to acute @entity1 exposure for firefighter and emergency medical service (EMS) personnel. The Acute @entity1 Exposure Response Scale (ATERS) was intended to assess firefighter and EMS personnel response to acute @entity1 exposure from analytical, emotional, and physical perspectives. METHODS: Data were analyzed on 97 firefighter and EMS personnel employed by a fire department in a mid-sized city in a western state. Principal component analysis (PCAR) using Winsteps software was employed to discover which variables in the set formed logical subsets that were independent of one another and included item analyses and assessment of internal consistency reliability (Cronbach's alpha). Rasch analysis included examination of dimensionality, @entity0 and item reliability, scale use and function, and construct validity including @entity0 -item fit statistics. RESULTS: Principal component analyses of residuals (PCAR) revealed three primary scales which were termed Emotional Psyche, Coping Ability, and Support Systems. Rasch analyses showed the ATERS performance to be acceptable as a new pilot measure with three distinct scales through reliability of @entity0 separation of .81 for Emotional Psyche, .66 for Coping Ability, and .63 for Support Systems, respectively (Nunnally and Bernstein, 1994; Carmines and Zeller, 1979; Devellis, 2012). The Rasch item reliability was .96 for Emotional Psyche, .95 for Coping Ability, and .97 for Support Systems. Response scale use and function was appropriate for each subscale. Validity was supported through PCA by evidence of good internal consistency. High item correlations indicated the items for each subscale were measuring a single construct. Likewise, Rasch analyses provided evidence of validity through an even spread of @entity0 ability to item difficulty for each of the three constructs. Good item fit provided proof of construct relevant variance and the absence of gaps along the unidimensional continuum indicated each construct to be represented adequately. CONCLUSION: The ATERS performs well as a measure of acute @entity1 exposure response for three primary constructs: Emotional Psyche, Coping Ability, and Support Systems with good Rasch @entity0 internal consistency reliability and factor structure. Items were deleted for each scale following PCA and Rasch analyses due to misfit and low loadings. Further research is recommended to optimally represent each construct in regards to @entity0 -item fit. Fire departments may utilize results of this study to assess current program effectiveness. Through evaluation, departments may incorporate programs and resources that are more effective at reducing stress associated with acute @entity1 , thereby increasing employees overall job satisfaction and performance.

title: Assessment of Acute XXXX Exposure Response for FIRE-EMS Personnel.

answer: @entity1


abstract: BACKGROUND: Intensive speech therapy improves language function in @entity0 with chronic @entity3 , although treatment in the acute phase is more effective than in the chronic phase. Unfortunately, most @entity0 with @entity1 go untreated due to socioeconomic problems. This study was performed to develop and test a speech therapy-based telerehabilitation program (iAphasia), suitable for use on a mobile device platform, which would expand access to therapy to @entity0 who frequently go untreated. SUBJECTS AND METHODS: We enrolled 8 @entity0 with @entity2 to receive therapy via our iPad(  ) (Apple, Cupertino, CA)-based telespeech therapy program, iAphasia. @entity0 received 4 weeks of telespeech therapy using iAphasia, which generates six domains with six levels of difficulty. We compared pre- and posttreatment scores on the Korean version of the Western Aphasia Battery (K-WAB) to evaluate effectiveness. Additionally, a 1-month follow-up assessment was performed. RESULTS: We investigated user satisfaction using a questionnaire to assess the feasibility of iAphasia. After the 4-week treatment, language function as measured by the K-WAB improved significantly. The improvement was persistent at the 1-month follow-up visit. The degree of improvement was strongly associated with usage time, regardless of @entity0 ' age and severity of @entity3 . Overall, satisfaction with iAphasia was rated high. CONCLUSIONS: The results from this study suggest it to be an effective and feasible treatment method for chronic @entity3 , although follow-up studies with more subjects and a control group are needed for a more thorough assessment.

title: A Telerehabilitation Approach for @entity2 Following XXXX .

answer: @entity1


abstract: PURPOSE: To report pathological outcomes and predictors of adverse pathology in @entity0 undergoing radical prostatectomy (RP) after an initial period of @entity1 ( @entity1 ). MATERIALS AND METHODS: We studied pathological outcomes in @entity0 who underwent RP after some time on @entity1 . Pathological outcomes were compared between @entity0 with and without evidence of disease reclassification on @entity1 . Rates of adverse pathology (defined as pathological stage>= pT3a, RP Gleason >= 4+3, or lymph node involvement) were determined, and were compared depending on the variable that defined disease reclassification. RESULTS: Of 1086 @entity0 enrolled in @entity1 , 130 (12.0%) underwent RP after a median time of 1.96 years (range 0.55-12.26 years) on @entity1 . 97 (74.6%) of these @entity0 had evidence of disease reclassification on @entity1 . Rates of adverse pathology were greater in @entity0 with evidence of reclassification compared to those without (p=0.05). Among @entity0 with disease reclassification, rates of adverse pathology ranged from 23.8% to 44.7% depending on the variable used to define reclassification. Longer time on @entity1 was not associated with adverse pathology (p=0.68). CONCLUSIONS: Adverse pathology after RP is more common in @entity0 with evidence of disease reclassification on @entity1 compared to those undergoing RP for other reasons. However, we identified varying outcomes among these @entity0 depending on the criterion that defined reclassification. These data may enable identification of @entity0 who can safely continue on @entity1 despite evidence of disease reclassification.

title: Predictors of Adverse Pathology in XXXX Undergoing Radical Prostatectomy Following Initial Active Surveillance.

answer: @entity0


abstract: OBJECTIVE: To report the anatomical and functional results of intravitreal injections of aflibercept (Eylea) (A-IVI) for the treatment of na  ve eyes with neovascular age-related @entity4 (nv- @entity6 ). SUBJECTS AND METHODS: This retrospective, one-center, non-comparative chart review included 26 treatment na  ve eyes with nv- @entity6 of 26 @entity0 (14 male) with a mean age of 80.5 (range 63-91) who had a complete follow-up of 14 months. The morphological analysis included spectral domain optical coherence tomography and fundus @entity3 angiography, while the functional assessment included logarithm of the minimum angle of resolution (LogMAR) best correct visual acuity (BCVA). The timing of the follow-up was: baseline, 3, 6, and 14 months. All @entity0 received 8 A-IVI according to the protocol (first 3 consecutive monthly A-IVI, followed by bi-monthly retreatment for the first year, regardless of disease activity as per local guidelines). Statistical analysis was performed using ANOVA. Improvement of visual acuity more than 15 letters was considered as "improvement", less than 5 letters as "stable" and any letter loss as "worsening". RESULTS: Mean  standard deviation LogMAR visual acuity improved from 0.26  0.15 at presentation to 0.14  0.20 at the final follow-up of 14 months (P=0.02). BCVA was stable in 23.1%, improved in 61.5% (16 eyes) worsened in 15.4%. A mean pretreatment central macular thickness of 409 m reduced significantly to 229 m at month 14 (P<0.02). The OCT of eyes with worsened BCVA showed resolution of retinal fluid but presence of subretinal @entity1 . No adverse events were attributed to aflibercept. CONCLUSIONS: @entity0 who had a worsening in visual acuity were found to have longer duration of symptoms prior to treatment and presence of @entity5 , and/or subretinal @entity2 and/or subretinal @entity1 at baseline. From our experience, with 14 months follow-up, A-IVI is an effective treatment for treatment na  ve @entity0 with nv- @entity6 . Our real world results were similar to pivotal trials.

title: Intravitreal aflibercept (A-IVI) for the treatment of neovascular age-related XXXX (nv- @entity6 ): one year experience.

answer: @entity4


abstract: BACKGROUND: @entity1 ( @entity1 ) and @entity4 ( @entity4 ) are chronic @entity2 of unknown aetiology of increasing incidence and changing disease activity or severity. Approximately 60-80% of @entity1 @entity0 suffer from @entity4 . Monitoring and treatment goals of @entity1 are to optimise the disease course by prolonging remission periods and preventing or shortening periods of active disease. Constant-care web-monitoring and treatment approaches with active @entity0 involvement have been proven effective in UC, increasing @entity0 ' adherence and improving the disease outcomes.    AIM: To assess the feasibility and efficacy of the novel constant-care eHealth applications in: i) @entity3 @entity0 treated with infliximab (IFX), ii) UC @entity0 with active disease on @entity5 , iii) @entity4 @entity0 and iv) @entity1 @entity0 with @entity4 on a low FODMAP diet (LFD).    METHODS: New constant-care web applications www.cd.constant-care.dk, www.meza.constant-care.dk and www.ibs.constant-care.dk in @entity1 @entity0 were developed and assessed in this thesis. An integrated inflammatory burden measure of disease activity, consisting of a subjective (clinical indices) and of an objective (faecal calprotectin) part and a treatment guide to drug doses and intervals, was incorporated into the web applications and used by @entity0 . RESULTS: Web-guided IFX treatment in @entity3 demonstrated @entity0 ' inter- and intra-individual variability in infusion intervals and provided @entity0 with individualised treatment according to their needs. Web-guided treatment with multimatrix @entity5 was efficacious in a majority of UC @entity0 with mild-to-moderate disease activity. Web-guided @entity4 -monitoring in @entity1 and in @entity4 @entity0 on LFD was shown to be a feasible method that actively involved @entity0 in their disease management and had a positive short-term impact on the disease. Moreover, the new constant-care concepts were demonstrated to be safe and to have a positive impact on quality of life and adherence to treatment and helped to reduce the costs.    CONCLUSIONS: The novel constant-care web applications have proven feasible in improving the disease outcomes in @entity3 @entity0 on IFX, in UC @entity0 on @entity5 , and in monitoring @entity4 . These applications are expected to be implemented in the clinical practice of gastroenterology in Denmark in the coming years. Future studies will help to assess whether the natural disease course can be improved in the long-term.

title: EHealth: self-management in @entity1 and in @entity4 using novel constant-care web applications. eHealth by constant-care in XXXX and @entity4 .

answer: @entity1


abstract: INTRODUCTION: Fewer than 5% of @entity5 (SCC) are presented in the maxilla. The absence of cervical @entity8 ( @entity8 ) is one of the main positive prognostic factors. This single-centre study analysed the cervical @entity8 behaviour in @entity0 with oral SCC of the upper jaw and serves as a basis for a cervical lymph node treatment suggestion. MATERIAL AND METHODS: The retrospective study includes 171 @entity0 with isolated SCC of the maxilla. In addition to @entity2 resection, 83% of the @entity0 underwent a selective @entity3 ( @entity3 ). The data of cervical @entity1 , TNM-status, @entity2 grade, @entity2 location as well as @entity6 and @entity4 behaviour were statistically analysed. RESULTS: The average rate of cervical @entity1 was 44% in total. @entity2 stage significantly affected risk for cervical @entity1 (T1  =  6%, T2  =  41%, T3  =  60% and T4  =  60%) (p  <  0.01). Development of cervical @entity8 was seemingly influenced by male gender. DISCUSSION: This study postulates a high rate of cervical @entity1 of maxillary SCC. Risk for @entity1 is mainly determined by the @entity2 stage. @entity4 and @entity6 abuse have a negative impact on cervical @entity8 . CONCLUSION: Reviewing recent literature underlined by the illustrated data, we put up for discussion the treatment of SCC of the maxilla as similar to therapy protocols for @entity7 . This would include an @entity3 even in low @entity2 stage and in T4 staged @entity2 on both sides. However, prospective multicentre studies are needed to verify and recommend these therapy assumptions.

title: Occurrence of cervical XXXX of @entity5 - A monocentric study of 171 @entity0 .

answer: @entity8


abstract: OBJECTIVE: To evaluate the risk of @entity4 after surgical excision of congenital @entity3 . DESIGN: Retrospective analysis and case series. SETTING: Tertiary care teaching hospital. @entity0 : A total of 13 pediatric @entity0 diagnosed with @entity3 with unilateral, bilateral, or circular lesions and more than 50% airway obstruction between 1992 and 2001. INTERVENTION: Open surgical excision was performed as a single-stage procedure either as primary or secondary intention. The cricoid cartilage was left open at the end of the procedure. Postoperative intubation was carried out in a pediatric intensive care unit. MAIN OUTCOME MEASURE: An adequate airway after surgical excision. RESULTS: All @entity0 were successfully extubated. No recurrence was noted. Three @entity0 developed @entity4 , two grade 1 and one grade 2. @entity5 showed a favorable outcome and did not require reintubation. One needed endoscopic management of the @entity2 . Of these 3 cases, 2 occurred after @entity1 laser treatment (out of 3) and 1 after circumferential dissection (out of 3). CONCLUSIONS: Extubation after surgery was successful in all cases of @entity3 . Risk of @entity4 was limited and occurred only after circumferential dissection, especially if associated with prior traumatic laser damage of the @entity3 .

title: Controlled risk of XXXX after surgical excision of @entity3 .

answer: @entity2


abstract: OBJECTIVE: To compare the efficacy and safety of selective penile denervation to that of circumcision for primary @entity1 (PPE). MATERIALS AND METHODS: A prospective study comprised 138 @entity0 with PPE, divided into two groups. @entity0 in Group 1 (n=50) underwent selective penile denervation by dissecting about a half of dorsal penile nerve branches. Large nerves (> 2 mm) were subjected to microsurgical neurorrhaphy. In group 2 (n=88) circumcision was carried out using guillotine technique. The evaluation of treatment efficacy was carried out using the Criteria for @entity1 questionnaire (CriPE), measuring intravaginal ejaculation latency time (IELT) with a stopwatch and testing penile vibration sensitivity. These examinations were performed at baseline and after 2, 4, 6, 8, 10 and 12 months after operation. RESULTS: By the end of follow-up, 88% and 10.2% of @entity0 of group 1 and group 2 had no signs of PPE, respectively. At 12 months IELT index increased 6-fold in @entity0 of group 1 from 53,6+/-12,7 to 335,6+/-81,5 seconds, while remaining unchanged in group 2 with 51,8+/-10,4 seconds at baseline and 53.9+/-20.1 seconds at the end of follow-up. Group 1 showed statistically significant and sustained reduction in penile vibration sensitivity compared with baseline (p<0,001). In group 2, the baseline and endpoint characteristics of bio-tensiometry did not differ significantly (p>0,05). CONCLUSIONS: The resulting effectiveness of selective penile denervation and circumcision for PPE was 88% and 10.2%, respectively, with comparable safety.

title: [Comparing efficacy of selective penile denervation and circumcision for primary XXXX ].

answer: @entity1


abstract: OBJECTIVE: To determine the clinic and ambulatory blood pressure when the same dose of @entity1 (4 mg) is administered in the morning (0900 h), or at night (2100 h), in particular, to determine whether the early morning blood pressure rise, the duration of effect and the pattern of response differed. METHODS: Twenty male @entity0 with diastolic blood pressure 95-110 mmHg when seated and 24 h mean ambulatory diastolic blood pressure > 85 mmHg after 4 weeks' placebo were allocated randomly to be administered 4 mg @entity1 at 0900 h or at 2100 h. Clinic blood pressure (with the @entity0 seated and erect) was measured 2 and 4 weeks after the therapy had been started and ambulatory blood pressure monitoring with a SpaceLabs device was performed for 26 h during week 4. The @entity0 then crossed over to the other time of dosage and the measurements were repeated. The study was conducted from a hospital clinic. RESULTS: The clinic analysis concerned all 20 @entity0 but the ambulatory analysis concerned 18 @entity0 because the ambulatory blood pressure monitor data sets were inadequate for two @entity0 . Compliance was high (97 +/- 3%), with a suggestion that it was better with the 0900 h dose. Clinic blood pressure (with the @entity0 seated and erect) was lower under both regimes and the blood pressure with night-time administration of @entity1 tended to be lower than that with daytime administration (P = 0.05-0.10). Twenty-four-hour mean, daytime and night-time means were lower with both doses than they were with placebo and did not differ. Both regimes reduced the early morning peak blood pressure rise and the effect tended to be greater with the 2100 h dose (P = 0.05-0.10). The 0900 h dose had an effect that persisted for > 24 h but the effect of the 2100 h dose had dissipated 18 h after the dose. There was no excessive night-time fall in blood pressure with the 2100 h dose. The trough : peak ratio with the 0900 h dose was 0.86 for systolic and 0.70 for diastolic blood pressure. CONCLUSION: The early morning blood pressure rise is reduced more when 4 mg @entity1 is administered at 2100 h. However, the 2100 h dose regime does not reduce blood pressure over 24 h whereas 24 h control is achieved with the 0900 h dose. In clinical practice the 2100 h dose would have been titrated to the next dose range in more @entity0 . This study indicates that the response profile obtained with an angiotensin converting enzyme inhibitor cannot be transformed from one dose time to another automatically and that chronobiology has important effects on a drug's action.

title: The effect on 24 h blood pressure control of an angiotensin converting enzyme inhibitor ( XXXX ) administered in the morning or at night.

answer: @entity1


abstract: BACKGROUND: The probability of response to chemotherapy following @entity4 based treatment in @entity2 has usually been related to the ' @entity4 -free interval'. However, in a recent European-Canadian trial of @entity7 , serous histology, @entity1 bulk, and hemoglobin, but not treatment free interval, were predictors of response. To determine if these observations were unique to this study (or this drug), data from other active agents given as second- or third-line treatment in @entity2 were obtained and analyzed. METHODS: In the first part of the study, results of trials in 1185 @entity4 pretreated @entity2 @entity0 were obtained on six agents: @entity7 , @entity6 , @entity5 , @entity9 , @entity8 , and @entity3 . Response results according to histology, baseline hemoglobin, @entity1 size and time from last chemotherapy were determined for each agent and the Cochran-Mantel-Haenszel procedure was used to obtain an overall assessment of significance for each factor. In the second part of the study, individual data from 704 @entity0 in four studies (three agents: @entity7 , @entity5 and @entity6 ) were pooled for univariate and multivariate analysis of factors predictive of response. RESULTS: In the analysis of results of individual agents all factors examined were significant predictors of response: serous histology (P = 0.001), @entity1 size < or = 5 cm (P = 0.02), normal baseline hemoglobin (P = 0.003), and > or = 6 mo since last treatment (P = 0.001). While these results were interesting, they did not supply definitive answers regarding independent response predictors. Therefore a multifactor analysis was undertaken on the 704 @entity0 for whom individual data were available. Of the 11 factors examined in a univariate analysis, 10 met the criteria for inclusion in a stepwise logistic regression. In the final model only 3 factors remained as significant independent predictors of response: serous histology (P = 0.009), no. disease sites (P = 0.003), and @entity1 size (P = 0.001). Time from last treatment, when evaluated as a continuous variable, was not in the final model and was highly correlated with @entity1 size (P = 0.0005). CONCLUSIONS: On the basis of this analysis, we conclude that @entity1 burden (as assessed by size of the largest lesion and number of disease sites) and histology are factors of importance in response to subsequent chemotherapy in relapsed @entity2 . Time from last treatment was correlated with @entity1 size in this data set and its effect on response was dependent on whether it was examined as a categorical or continuous variable, so we conclude it is not the sole critical factor of biologic importance. We recommend description of these factors in reports of phase II studies, confirmation of these findings in other data sets and further investigation of the mechanism of sensitivity of serous @entity1 .

title: Predictors of response to subsequent chemotherapy in @entity4 pretreated @entity2 : a multivariate analysis of 704 XXXX [seecomments].

answer: @entity0


abstract: UNASSIGNED: Approximately up to 40% of @entity1 with @entity2 develop bone @entity3 , with 22% to 59% of them experiencing skeletal-related events (SREs), which result in an important quality of life deterioration and economic burden. Denosumab, a fully human antibody that targets the receptor activator of nuclear factor-kB (RANK) ligand ( @entity8 ), is indicated for prevention of SREs in @entity1 with @entity4 and has demonstrated superiority in @entity0 , and in other @entity4 , in reducing the risk of first SRE by 17% versus @entity7 . In the subset of @entity1 with @entity5 ( @entity5 ), denosumab has also shown a positive trend to SRE risk reduction. Denosumab might have direct or indirect antitumor effects. @entity4 cells produce factors that stimulate increased bone resorption by osteoclasts, which in turn release @entity4 growth factors into the bone microenvironment, initiating a @entity4 /bone vicious cycle. An increasing body of evidence suggests RANK/ @entity8 signaling plays a role in this tumorigenesis. Both proteins are overexpressed in different @entity4 types including @entity2 cells. RANK/ @entity8 signaling activates nuclear factor-kB pathways related to lung carcinogenesis and increases @entity6 expression and @entity9 /extracellular signal-regulated kinase phosphorylation, which in turn enhances @entity4 cell migration. In animal @entity5 models, denosumab delayed bone @entity3 and reduced skeletal @entity4 growth. In @entity1 with @entity2 (post hoc analysis), denosumab prolonged overall survival by 1.2 months versus @entity7 (P  = .01). This hypothesis-generating outcome warrants further investigation and 2 studies in @entity2 are ongoing to elucidate the therapeutic potential of denosumab beyond SRE prevention.

title: Therapeutic Potential of Denosumab in @entity1 With XXXX : Beyond Prevention of Skeletal Complications.

answer: @entity2


abstract: Many of the beneficial and toxic biological effects of nanoparticles have been shown to have a negative correlation with particle size. However, few studies have demonstrated biological effects that only occur at specific nanoparticle sizes. Further elucidation of the size-specific biological effects of nanoparticles may reveal not only unknown @entity2 , but also novel benefits of nanoparticles. We used surface-unmodified @entity6 particles with a wide range of diameters and narrow size intervals between the diameters (10, 30, 50, 70, 100, 300, and 1000 nm) to investigate the relationship between particle size and acute @entity2 after intravenous administration in @entity0 . Negative correlations between particle size and @entity4 , @entity3 , and lethal @entity2 were observed. However, a specific size-effect was observed for the severity of @entity5 , where @entity6 nanoparticles with a diameter of 50 nm induced the most severe @entity5 . Further investigation revealed that this @entity5 was mediated not by @entity1 , but by platelet-activating factor, and it was independent of the @entity4 and the @entity3 . In addition, macrophages/Kupffer cells and platelets, but not neutrophils, play a critical role in the @entity5 . The present results reveal that @entity6 nanoparticles have particle size-specific @entity2 in @entity0 , suggesting that other types of nanoparticles may also have biological effects that only manifest at specific particle sizes. Further study of the size-specific effects of nanoparticles is essential for safer and more effective nanomedicines.

title: Identifying a size-specific hazard of @entity6 nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in XXXX .

answer: @entity0


abstract: The stress-inducible protein @entity7 provides protection against oxidative stress and modulates pro-inflammatory cytokines. As the @entity4 results from the release of pro-inflammatory mediators, we postulated that @entity7 and its enzymatic product CO would protect against lethality in a @entity0 model of @entity1 . @entity0 treated with a lethal dose of lipopolysaccharide (LPS) and subsequently exposed to inhaled CO had significantly better survival and lower serum interleukin (IL)-6 and @entity2 levels than their untreated counterparts. In vitro, @entity0 macrophages exposed to LPS and CO had significantly attenuated @entity3 production; this effect was concentration-dependent and occurred at a transcriptional level. The same effect was seen with increased endogenous CO production through overexpression of @entity7 . Mutation within the @entity5 -binding site in the @entity3 promoter diminished the effect of CO on promoter activity, and treatment of macrophages with CO decreased @entity5 binding in an electrophoretic mobility shift assay. Electrophoretic mobility supershift assay indicated that the @entity10 , @entity11 , and @entity6 components of @entity5 were particularly affected. Upstream of @entity5 , CO decreased @entity8 phosphorylation in @entity0 macrophages and lung endothelial cells. @entity0 deficient in the @entity8 pathway had decreased serum levels of @entity3 and @entity2 in response to LPS compared with control @entity0 , and no effect of CO on these cytokine levels was seen in @entity8 or @entity9 genedeleted @entity0 . In summary, these results suggest that CO provides protection in a @entity0 model of @entity1 through modulation of inflammatory cytokine production. For the first time, the effect of CO is shown to be mediated via the @entity8 signaling pathway and the transcription factor @entity5 .

title: Suppression of inflammatory cytokine production by carbon monoxide involves the XXXX pathway and @entity5 .

answer: @entity8


abstract: Specific IgE anti-ragweed antibodies (IgEAR) were measured over two years in two groups of highly sensitive @entity0 treated (immunized) with either ragweed extract or placebo and in a third group of placebo-treated, relatively insensitive @entity0 . The IgEAR on the @entity0 ' basophils were assessed by ragweed antigen E (AgE)-induced @entity1 release; blocking (IgG) antibodies were measured by their ability to inhibit AgE induced @entity1 release. These data were evaluated against the clinical severity of ragweed hay @entity2 in each @entity0 . WE FOUND THAT: (a) In placebo treated @entity0 IgEAR usually declined gradually prior to the ragweed season and were boosted by environmental exposure to ragweed pollen. (b) In immunized @entity0 the IgEAR rose at the beginning of treatment, but fell as immunotherapy proceeded; by the end of the second year the levels had decreased in 18/19 @entity0 . (c) The increase in blocking antibody during immunotherapy correlated significantly (P < 0.05) with the decrease in serum IgEAR. (d) Judged by their sensitivity to AgE induced @entity1 release, IgEAR on basophils correlated significantly with IgEAR in the serum of untreated @entity0 (P < 0.01). (e) The highly sensitive placebo treated @entity0 ' symptom scores were significantly correlated with their IgEAR in serum (P < 0.01) and with the sensitivity of their basophils to AgE-induced @entity1 release (P < 0.01). Neither correlation was observed in the relatively insensitive @entity0 . (f) In the treated group the IgEAR measurements predicted neither the degree of their illness nor their clinical improvement We conclude tha IgE antibody measurements may be useful in the assessment of the severity of reaginic @entity3 in highly sensitive @entity0 . Its use in modestly sensitive @entity0 requires @entity0 requires further study, as does the inverse association between IgE and IgG antiragweed antibodies.

title: IgE antibody measurements in ragweed hay XXXX . Relationship to clinical severity and the results of immunotherapy.

answer: @entity2


abstract: In the @entity0 brain, the transformation of radial glial cells (RGC) into astrocytes has been studied only rarely. In this work, we were interested in studying the morphologic aspects underlying this transformation during the fetal/perinatal period, particularly emphasizing the region-specific glial fiber anatomy in the medial cortex. We have used @entity6 dyes ( @entity5 / @entity7 ) to identify the RGC transitional forms and glial fiber morphology. Immunocytochemical markers such as vimentin and @entity1 ( @entity1 ) were also employed to label the radial cells of glial lineage and to reveal the early pattern of astrocyte distribution. Neuronal markers such as @entity3 ( @entity3 ) and @entity2 ( @entity4 ) were employed to discern whether or not these radial cells could, in fact, be neurons or neuronal precursors. The main findings concern the beginning of RGC transformation showing loss of the ventricular fixation in most cases, followed by transitional figures and the appearance of mature astrocytes. In addition, diverse fiber morphology related to depth within the cortical mantle was clearly demonstrated. We concluded that during the fetal/perinatal period the cerebral cortex is undergoing the final stages of radial neuronal migration, followed by involution of RGC ventricular processes and transformation into astrocytes. None of the transitional or other radial glia were positive for neuronal markers. Furthermore, the differential morphology of RGC fibers according to depth suggests that factors may act locally in the subplate and could have a role in the process of cortical RGC transformation and astrocyte localization. The early pattern of astrocyte distribution is bilaminar, sparing the cortical plate. Few astrocytes ( @entity1 +) in the upper band could be found with radial processes at anytime. This suggests that astrocytes in the marginal zone could be derived from different precursors than those that differentiate from RGCs during this period.

title: Cortical radial glial cells in XXXX fetuses: depth-correlated transformation into astrocytes.

answer: @entity0


abstract: The differences of neuromuscular junctions (NMJs) between different muscle fibers had been examined with scanning electron microscopy and analyzed morphometrically. The anterior and posterior latissimus dorsi muscles of the @entity3 were compared. The former consisted exclusively of slow tonic fibers and the latter of fast twitch fibers. The former had numerous, small NMJs. The @entity1 were small in number. The latter had a large NMJ. The @entity1 were large in number, and subsynaptic folds were found. The extensor digitorum longus and soleus muscles in the @entity0 were also compared. The former consisted mostly of fast twitch fibers whereas the latter consisted of slow twitch fibers (75%) and fast twitch fibers (25%). NMJ of slow twitch fiber was small and the subsynaptic folds had sparse, @entity2 . NMJ of fast twitch fiber was large and the subsynaptic folds had numerous, wide and slit-like openings.

title: [A scanning electron microscopical and morphometrical analysis of neuromuscular junctions in different muscle fiber types in the @entity3 and XXXX ].

answer: @entity0


abstract: BACKGROUND: -Although vascular smooth muscle cell (VSMC) proliferation is implicated in atherogenesis, VSMCs in advanced plaques and cultured from plaques show evidence of VSMC senescence and DNA damage. In particular plaque VSMCs show shortening of telomeres, which can directly induce senescence. Senescence can have multiple effects on plaque development and morphology; however, the consequences of VSMC senescence or the mechanisms underlying VSMC senescence in @entity3 are mostly unknown. METHODS AND RESULTS: -We examined expression of proteins that protect telomeres in VSMCs derived from @entity0 plaques and normal vessels. Plaque VSMCs showed reduced expression and telomere binding of @entity6 ( @entity6 ), associated with increased DNA damage. @entity6 expression was regulated by @entity4 -dependent degradation of @entity6 protein. To examine the functional consequences of loss of @entity6 , we expressed @entity6 or a @entity6 functional mutant ( @entity7 ) as either gain or loss of function studies in vitro and in @entity5 (-/-) @entity1 . @entity6 overexpression bypassed senescence, reduced DNA damage, and accelerated DNA repair, whereas @entity6 (188A) showed opposite effects. @entity1 expressing VSMC-specific @entity6 ( @entity7 ) showed increased @entity3 and @entity2 core formation in vivo, whereas VSMC-specific @entity6 increased relative fibrous cap and decreased @entity2 core areas. @entity6 protected against @entity3 independent of secretion of senescence-associated cytokines. CONCLUSIONS: -We conclude that plaque VSMC senescence in @entity3 is associated with loss of @entity6 . VSMC senescence promotes both @entity3 and features of plaque vulnerability, identifying prevention of senescence as a potential target for intervention.

title: Vascular Smooth Muscle Cell Senescence Promotes XXXX and Features of Plaque Vulnerability.

answer: @entity3


abstract: Glucocorticoids have been used in the treatment of inflammatory and @entity5 and to prevent graft rejection for over 50 years. These hormones exert their effects through cytoplasmic, @entity7 protein-bound glucocorticoid receptors that translocate into the nucleus, where they regulate the transcriptional activity of responsive genes by binding to specific promoter DNA sequences (transactivation) or by interacting with transcription factors (transrepression). By interacting with different signaling pathways, newly characterized nuclear receptor coregulators enhance or diminish the actions of glucocorticoids, thus explaining the gene-, cell-, tissue- and context-dependent actions of glucocorticoids. Glucocorticoids modulate genes involved in the priming of the innate immune response, while their actions on the adaptive immune response are to suppress cellular [T helper (Th)1-directed] immunity and promote humoral (Th2-directed) immunity and tolerance. The past decade has produced new insights into the mechanisms of glucocorticoid sensitivity and resistance of inflammatory, autoimmune and @entity2 . Both the quality and severity of the inflammatory stimulus, as well as the genetics and constitution of the @entity0 , play key roles in the glucocorticoid sensitivity, dependency and resistance of these diseases. Although glucocorticoids increase susceptibility to @entity6 , they are also highly beneficial in the presence of serious systemic @entity1 , such as that observed in @entity3 and acute @entity4 , when administered in a sustained fashion throughout the course of the disease. Glucocorticoids produce their cardiovascular, metabolic and antigrowth side effects through molecular mechanisms distinct from those involved in immunomodulation. Fortunately, the first generation of tissue- and immune- versus cardiovascular/metabolic effect-selective glucocorticoids is available for study and further improvement. 'Designer' glucocorticoids promise to be a great new advance in the therapy of inflammatory diseases.

title: Glucocorticoids and XXXX revisited: the state of the art. NIH clinical staff conference.

answer: @entity1


abstract: OBJECTIVE: To quantify the collagen fibers in the lacrimal gland of female @entity0 with @entity5 . METHODS: Forty adult female @entity0 were randomly divided into two groups with 20 animals each: nonpregnant control ( @entity6 , control group, 0.2 mL of saline solution) and nonpregnant experimental (HPRL1, experimental group, 200   g/day @entity4 ). Treatments lasted for 50 consecutive days. On day 50, 10 females from each group (control and experimental) were euthanized in the proestrus phase; then, the blood was collected and the lacrimal glands were removed. Thereafter, the remaining females were placed with the mates and continued to receive treatment with saline solution or @entity4 . On the 6th post-coital day, 10 pregnant females from the control group ( @entity7 ) and 10 pregnant females from the experimental group (HPRL2) were euthanized, after which blood was collected and the lacrimal glands removed. The lacrimal glands were processed for morphological analyses and collagen quantification, and prolactin and sex @entity2 levels were measured in the blood samples. Data were statistically analyzed using an unpaired Student t test (p<0.05). RESULTS: Morphological analysis revealed greater structural tissue disorganization of the lacrimal glands in the @entity4 -treated groups. The total collagen content was significantly higher in the HPRL1 group than in the @entity6 group (p<0.05), whereas the difference between the @entity7 and HPRL2 groups was not significant. CONCLUSION: Our data suggest an impairment in the functioning of the lacrimal gland as a consequence of increased prolactin levels and decreased serum levels of @entity1 and @entity3 .

title: Influence of XXXX on collagen fibers in the lacrimal gland of female @entity0 .

answer: @entity5


abstract: Eighty two @entity0 with chronic @entity1 and 17 @entity0 with @entity5 chronica multiformis were referred to our department from October 2004 to February 2007 and were tested for @entity2 @entity2 antigen using the polyclonal H.  @entity2 stool antigen test (enzyme-linked immunosorbent assay method). H.  @entity2 antigen was detected in 25 (30.5%) of the 82 @entity0 with chronic @entity1 and in 10 (58.8%) of the 17 @entity0 with @entity5 chronica multiformis. Those findings were not significantly higher than the positive rate for H.  @entity2 stool antigen in healthy age-matched controls. In @entity0 positive for H.  @entity2 antigen, seven of the 25 with chronic @entity1 had complications of @entity4 (six @entity0 ) or @entity3 (one @entity0 ). Three of the 10 @entity0 with @entity5 chronica multiformis had complications of @entity4 (two @entity0 ) or @entity3 (one @entity0 ). We examined the therapeutic efficacy of antibacterial treatment for the 17 @entity0 with chronic @entity1 and the eight @entity0 with @entity5 chronica multiformis who were positive for H.  @entity2 antigen and accepted the treatment based on informed consent. We evaluated the effectiveness of treatment by scoring the skin conditions and by using the Skindex-16, a measure of quality of life. The eradication therapy for @entity2 was more effective for treating @entity5 chronica multiformis and the skin symptoms started to improve within 3-14   days after the therapy. However, that therapy was not always effective for treating chronic @entity1 . We suggest that @entity2 may be an important pathogenetic factor, especially for @entity5 chronica multiformis, and that eradication therapy should be considered to treat intractable cases.

title: Clinical study of the relationship between XXXX and chronic @entity1 and @entity5 chronica multiformis: effectiveness of eradication therapy for @entity2 .

answer: @entity2


abstract: BACKGROUND AND AIMS: Meta-analyses point to a modest but significant effect of probiotics on symptoms in @entity2 ( @entity2 ). We aimed to assess the effect of the probiotic Lactobacillus casei Shirota (LcS) on symptoms and quality of life in @entity2 @entity0 in a randomized, double-blind, placebo-controlled intervention study. MATERIALS AND METHODS: @entity2 @entity0 (Rome II) between 18 and 65 years of age were included. The study consisted of an 8-week intervention period in which the @entity0 received probiotic (LcS) or placebo twice daily, followed by an 8-week follow-up period. Symptom diaries and quality of life were scored at weeks 0, 8 and 16. The primary outcome parameter was a decrease of at least 30% in a composite @entity1 ( @entity1 ) at week 8 on the basis of an intention-to-treat analysis. RESULTS: Thirty-nine individuals (67% @entity0 ) were included in the probiotic group and 41 individuals (71% @entity0 ) were included in the placebo group. After the intervention period, the mean relative improvement did not reach 30% for @entity1 or any individual symptom score. After follow-up (week 16), a mean improvement of at least 30% was achieved for @entity1 in the probiotic group, but no significant difference was found between both treatment groups (mean  SD: 34  7%; 13  8%, P=0.06). CONCLUSION: After probiotic treatment with LcS, no improvement of 30% in @entity1 was observed after 8 weeks.

title: Efficacy of Lactobacillus casei Shirota for XXXX with @entity2 .

answer: @entity0


abstract: OBJECTIVE: To increase @entity4 in the first 28 days after birth for very low birth weight (VLBW) @entity0 by isolating and sharing meaningful process differences between high- and low-weight-gain centers within a neonatal network. DESIGN/METHODS: We identified @entity4 as an important target for improvement in 1999 for our national group practice of neonatologists. Site-specific average @entity4 during the first 28 days was the primary outcome measure. Our target population was defined as inborn @entity0 who survived and remained in the hospital of birth, whose birth weights were between 401 and 1500 g (VLBW), and who were >22 weeks' estimated gestational age. A team of 6 neonatologists and 1 nurse met, reviewed processes that might influence growth, and developed a structured observation guide for site visits. Weight gain data were obtained from an existing administrative database for the period January 1, 1997, through June 30, 1999. Centers were ranked and divided into upper, middle, and lower thirds. Seven team members visited 1 high- and 1 low-weight-gain center without being informed of the center's performance. Following the site visits, the team isolated 16 meaningful differences between high- and low-weight-gain sites. Meaningful differences were defined as processes observed in all or virtually all (for this project, 6 or 7 of 7 centers) of the high and none or virtually none (for this project, 0 or 1 of 7) of the low centers. The meaningful differences were distributed to our medical directors in August 2000 along with their site-specific weight-gain performance. To document the impact of sharing this material, we compared @entity4 in a baseline period of January 1 through December 31, 1999 and a posteducational intervention period of January 1 through September 30, 2001. RESULTS: Compared with neonates admitted to our national neonatal practice in 1999, neonates admitted in 2001 were similar in birth weight, gestational age at birth, exposure to antenatal @entity1 , and male gender. Average daily @entity4 during the first 28 days increased from 10.4 +/- 6 g for neonates cared for in 1999 to 12.5 +/- 6 g for neonates cared for in 2001. Thirty-nine of 51 (76%) units noted improvements, 4 were unchanged and 8 noted a decrease in average @entity4 . Despite similar average lengths of stay, the average discharge weight for neonates sent home increased from 2.15 +/- 0.5 kg for 1999 to 2.29 +/- 0.5 kg for 2001. There were no differences in frequencies of mortality or major morbidities, including severe @entity2 , @entity3 , or @entity5 , between the 2 time periods. An increase in the use of continuous positive airway pressure was noted in the post implementation period. CONCLUSIONS: Variation in common processes can alter clinical outcomes. Although temporal trends in @entity4 may be, in part, responsible for this trend, it appears that isolation and implementation of meaningful differences in processes can augment our desire to rapidly improve clinical outcomes.

title: Improving growth of very low birth weight XXXX in the first 28 days.

answer: @entity0


abstract: @entity1 is the leading cause of @entity3 worldwide. Even early-stage @entity0 might encounter disease recurrence with relative high risk. Effective postoperative therapy is based on an accurate assessment of treatment failure after surgery. The aim of this study is to construct a disease-free survival (DFS) prediction model and stratify @entity0 into different risk score groups.A total of 356 pathological stage I @entity0 (7th American Joint Committee on @entity3 ) who underwent lung resection from January 2005 through June 2011 were retrospectively reviewed. Of these @entity0 , 63 @entity0 were eliminated for this study. A total of 293 p-stage I @entity0 were included for further univariate and multivariate analysis. Clinical, surgical, and pathological factors associated with high risk of recurrence were analyzed, including age, gender, smoking status, additional primary malignancy (APM), operation method, histology, visceral @entity2 , angiolymphatic invasion, @entity3 necrosis, and @entity3 size.Of the 293 p-stage I @entity5 ( @entity5 ) @entity0 examined, 143 were female and 150 were male, with a mean age of 62.8-years old (range: 25-83-years old). The 5-year DFS and overall survival rates after surgery were 58.9% and 75.3%, respectively. On multivariate analysis, current smoker (hazards ratio [HR]: 1.63), APM (HR: 1.86), @entity3 size (HR: 1.54, 2.03), nonanatomic resections (HR: 1.81), @entity4 histology (HR: 2.07), visceral @entity2 (HR: 1.54), and angiolymphatic invasion (HR: 1.53) were found to be associated with a higher risk of @entity3 recurrence. The final model showed a fair discrimination ability (C-statistic=0.68). According to the difference risk group, we found @entity0 with intermediate or higher risk group had a higher distal relapse tendency as compared with low risk group (P=0.016, odds ratio: 3.31, 95% confidence interval: 1.21-9.03).Greater than 30% of disease recurrences occurred after surgery for stage I @entity5 @entity0 . That is why we try to establish an effective DFS predicting model based on clinical, pathological, and surgical covariates. However, our initial results still need to be validated and refined into greater population for better application in clinical use.

title: Recurrence Risk Factors Analysis for Stage I XXXX .

answer: @entity5


abstract: INTRODUCTION: @entity4 ( @entity4 ) biopsy, primary used as an alternative to elective lymph node dissection in @entity3 , is being applied successfully in management of @entity1 with @entity0 . The aim of this method in @entity0 is to determine the presence of axillary node involvement while clinically normal axilla. The validity of the sentinel node concept in @entity0 is demonstrated in various studies. The results of identification rates, sensitivity, overall accuracy and false negative rate are so encouraging in most publications, as to implement this concept to every-day surgical practice. There is lack, however, of many fundamental answers pertaining relationship between @entity2 -size and the results of @entity4 Biopsy or related surgical standards. MATERIALS AND METHODS: 36 females at the age 33-66, with @entity0 underwent primary surgical treatment with @entity4 Biopsy in Department of Gynaecology and Oncology Jagiellonian University between 2001-2002. The study inclusion criteria were @entity2 size-T1, T2. The day before surgery the static scanning was performed after injection of Tc radiolabelled nannocolloid. @entity4 (s) were identified intraoperatively using a handheld gamma detection probe (Navigator GPS) and intraoperative lymphatic mapping with blue dye (Patent @entity5 V). After localization and excision of @entity4 (s), axillary's lymph node dissection (ALND) was performed. RESULTS: In 34 @entity1 @entity4 Biopsy revealed accumulation of the tracer in axilla, which was classified as @entity4 . Detection rate was 94.4% (34/36). Overall sensitivity of the procedure was 81%, whereas negative predictive value 92%. False negative rate was 2.2%. Detection rate for T1 @entity2 was 100% (15/15 cases), and for T2 @entity2 was 90.4% (19/21 cases). Sensitivity for @entity2 classified as T1 was 100% (3/3 cases), whereas for @entity2 T2 was 75% (6/8 cases). CONCLUSION: @entity4 Biopsy seems to be very interesting alternative to ALND in @entity1 with @entity2 's dimension.

title: [Sentinel node biopsy in XXXX and @entity2 dimension].

answer: @entity0


abstract: OBJECTIVE: Lumbo-pelvic core stabilization training (LPST) is one of the therapeutic exercises common in practice for rehabilitation of @entity0 with @entity1 . This study was carried out to examine the therapeutic effects of LPST on the muscle thickness of transversus abdominis (TrA) at rest and during contraction among @entity0 with chronic non-specific @entity1 . MATERIALS AND METHODS: A total of 25 @entity0 (7 males and 18 females) with chronic non-specific @entity1 participated in a within-subject, repeated measures, double-blinded, placebo-controlled comparisons trial. The @entity0 received three different types of experimental therapeutic training conditions which includes the lumbo-pelvic core stabilization training (LPST), the placebo treatment with passive cycling (PC) and a controlled intervention with rest (CI). The interventions were carried out by randomization with 48 hours between the sessions. The effectiveness of interventions was studied by measuring the changes in muscle thickness of TrA at rest and during contraction using a real time ultrasonography. RESULTS: Repeated measures ANOVA demonstrated that the LPST provided significant therapeutic benefits as measured by an increase in the muscle thickness of the TrA at rest (p<0.05) and during contraction (p<0.01). The percentage change of the muscle thickness observed during LPST was significantly higher (p<0.01) when compared to the other two experimental training conditions. CONCLUSIONS: The findings indicated that the LPST might provide therapeutic benefits by increasing the muscle thickness and function of TrA. Therefore, it is suggested that LPST technique should be considered as part of management program for treatment of @entity1 .

title: Changes in Transversus Abdominis Muscle Thickness after Lumbo-Pelvic Core Stabilization Training among XXXX Individuals.

answer: @entity1


abstract: UNASSIGNED: Parallel imaging is essential for the acceleration of abdominal and pelvic 2D multi-slice imaging, in order to reduce scan time and mitigate motion artifacts. @entity0 ( @entity0 ) accelerated imaging has been shown to increase the signal-to-noise ratio (SNR) significantly compared with in-plane parallel imaging with similar acceleration. We hypothesize that for @entity0 -accelerated abdominal imaging the consistency of image quality and SNR is more difficult to achieve due to the subject-specific coil sensitivity profiles, caused by (1) flexible coil placement; (2) variations in anatomy; and (3) variations in scan coverage along the superior-inferior direction. To test this, a mathematical framework is introduced that calculates the (retained) SNR for in-plane and @entity1 ( @entity1 )-accelerated acquisitions. Moreover, this framework was used to optimize the sampling pattern by maximizing the local SNR within a region of interest (ROI) through non-linear, RF-induced @entity0 slice shifts. The framework was evaluated on 14 healthy subjects and the optimized sampling pattern was compared with in-plane acceleration and @entity0 acceleration with linear slice shifts, which are primarily used in brain imaging. We demonstrate that the field of view (FOV) in the superior-inferior direction, the coil positioning and the individual anatomy have a large impact on the image SNR (changes up to 50% for varying coil positions and 40% differences between subjects) and image artifacts for @entity1 acceleration. Consequently, sampling patterns have to be optimized for acquisitions employing different FOVs and ideally on an individual basis. Optimization of the sampling pattern, which exploits non-linear shifts between slices, showed a considerable SNR increase (10-30%) for higher acceleration factors. The framework outlined in this article can be used to optimize sampling patterns for a broad range of accelerated body acquisitions on an individual basis. Copyright    2015 John Wiley _ Sons, Ltd.

title: An optimization framework to maximize signal-to-noise ratio in XXXX body imaging.

answer: @entity1


abstract: PURPOSE: To evaluate the usefulness of transcatheter @entity4 (TAE) through the omental branch in the treatment of @entity2 ( @entity2 ) with blood supply from the omental branch. MATERIALS AND METHODS: Fifteen @entity0 with @entity2 fed by the omental branch underwent TAE. All but one had previously undergone several therapies for @entity2 , including TAE. Three @entity0 had intraperitoneal @entity3 caused by @entity2 fed by the omental branch, and two necessitated emergency TAE. The technical success rate, therapeutic effect, and safety of TAE via the omental branch were evaluated. RESULTS: Twenty-six omental branches that fed @entity2 were observed angiographically. Attenuation or occlusion of the hepatic artery was observed in 80%. @entity5 (73%) could be successfully embolized. Hepatic hemostasis was achieved in all @entity0 with @entity2 . @entity1 recurred in 80% of @entity0 who underwent successful TAE of the omental branch, and additional therapy was performed in six @entity0 . Ten @entity0 died after 2-26 months (mean, 8 mo). Five @entity0 were alive for 3-13 months (mean, 7 mo). Severe complications were not observed in any @entity0 . CONCLUSION: TAE of the omental branch is safe and has become technically feasible in almost all @entity0 , but @entity1 frequently recur.

title: XXXX with blood supply from omental branches: treatment with transcatheter @entity4 .

answer: @entity2


abstract: Detection of @entity0 colonized in the pharynx of healthy carriers currently relies on conventional culture methods of direct plating with pharyngeal swab specimens. The accurate measurement of the carriage of pneumococci, however, has not been necessarily achieved with these methods due to low density colonization and contamination of numerous oral streptococci that express a- @entity1 . A PCR-based detection method of pneumococci-specific for lytA as well as PCR serotyping of @entity2 was recently developed and their effectiveness was confirmed. We modified the reaction conditions of these methods to improve the detection rate and applied them to the measurement of @entity2 carried in healthy adults. Pharyngeal swab specimens obtained from 110 healthy volunteers over 40 and living in Nagoya were enriched for 5 hours with broth medium supplemented with rabbit serum and the template DNA for PCR was extracted from the mixed enriched culture. Of 110 specimens 36 (32.7%) were lytA-positive, the rate of which was much higher than the results of previous culture-based studies. The DNA template preparations were then used for PCR-based serotyping with primers specific for each of the types included in pneumococcal 23 valent vaccine (PPV23). We found that 28 out of 36 lytA-positive carriers were identified as being positive for the serotypes belonging to PPV23, although serotypes 6A and 6B were indistinguishable with the PCR method. The most frequent serotype was serotype 14, and serotypes 4, 18C, and 6A/B were also frequently identified. Five lytA-positive carriers were previously vaccinated with PPV23, and among them, 4 were positive for serotypes contained in PPV23. We recommend PCR-based identification and serotyping of @entity2 in broth enrichment culture of pharyngeal swab specimens as a reliable method for the surveillance of healthy carriers with low density colonization.

title: [Detection and Serotyping of XXXX Carried in Healthy Adults with a Modified PCR Method].

answer: @entity0


abstract: BACKGROUND: The @entity4 classification for @entity2 was first introduced in the 7th edition, which was published in 2009; however, prognostic accuracy compared with the 5th and 6th editions has not yet been evaluated and requires validation. METHODS: A prospective histological database of @entity0 with @entity3 was analyzed, and histological parameters and stage of the @entity2 were assessed according to the 5th, 6th, and 7th editions of the @entity4 classification. RESULTS: Between 1994 and 2012, a total of 516 @entity0 underwent pancreatic head resection, of whom 59 @entity0 (11.4  %) experienced histologically confirmed @entity2 . The median overall survival time was 22.2 months (13.1-31.4). @entity1 recurrence occurred in 23 @entity0 after a median disease-free survival time of 14.1  months. The 7th edition showed a monotonicity of all gradients, with a stepwise increase of mortality related to a stepwise increase of @entity1 stage (log-rank test; p  <  0.05) demonstrating best discrimination of all tested editions [area under the receiver operating characteristic curve (AUC)  0.82; 95  % CI 0.70-0.95; p  =  0.012]. The discrimination rate was low for the 5th (AUC  0.67; 95  % CI 0.42-0.91; p  =  0.18) and 6th editions (AUC  0.70; 95  % CI 0.47-0.93; p  =  0.11), while the log-rank test did not reach statistical significance. On multivariate analysis, lymph node involvement and positive resection margins were positive and independent predictors of inferior survival (p  <  0.05). CONCLUSIONS: The 7th edition of the @entity4 classification was favorable in terms of predicting outcome, and generated a monotonicity of all grades. Strikingly, the 7th edition, but not the 5th and 6th editions, was of prognostic significance to predict outcome.

title: Prognostic Accuracy of the Seventh Edition of the XXXX Classification Compared with the Fifth and Sixth Edition for @entity2 .

answer: @entity4


abstract: OBJECTIVE: To study the influence of multiple @entity2 cells on differentiation of endothelial cells to form capillary-like networks and the role of @entity3 ( @entity3 ) in this process. METHODS: @entity0 multiple @entity2 cell line RPMI8226 or fresh @entity2 cells were co-cultured with @entity0 umbilical vein endothelial cells (HUVECs) in two different systems: the contact and the non-contact systems. The HUVECs cultured alone were used as control. The effects of soluble cytokine and adhesion molecule on angiogenesis in HUVECs co-cultured with MM cell were studied by modified Matrigel capillary-like networks formation assay and @entity3 levels in co-culture system supernatant by enzyme-linked immunosorbent assay. In the contact co-culture system, the formation of capillary-like networks and the secretion of @entity3 were detected again after MM cell was preincubated and cultured with anti- @entity4 and anti- @entity1 monoclonal antibodies. RESULTS: In RPMI8226 co-culture system, the number of capillary-like structure was increased in non-contact HUVECs system compared with that in monoculture, but the increase was lower than that of contact HUVECs system (75% vs. 113%). In fresh @entity2 cells co-culture system, the numbers of capillary-like structure were 138% and 188% for the non-contact and the contact co-culture systems, respectively, above that in HUVECs cultured alone. The median @entity3 concentrations in culture supernatants of mono-cultured, contact co-cultured with RPMI8226, non-contact co-cultured with RPMI8226, contact co-cultured with fresh @entity2 cells and non-contact co-cultured with fresh @entity2 cells were (12.4 +/- 5.1) ng/ ml, (38.5 +/- 8.2) ng/ml, (31.6 +/- 7.2) ng/ml, (37.1 +/- 8.7) ng/ml and(27.9 +/- 7.6) ng/ml, respectively. Either of the two adhesion molecule monoclonal antibodies reduced the capillary-like networks formation and the @entity3 secretion in the contact co-culture system. CONCLUSION: @entity0 multiple @entity2 cells stimulate differentiation of endothelial cells to form capillary-like networks in two different co-culture systems. @entity3 takes part in this progress and is modulated by soluble cytokine and adhesion molecule expressed by both kinds of cells.

title: [ XXXX multiple @entity2 cells stimulate differentiation of endothelial cells to form capillary-like networks in two different co-culture systems].

answer: @entity0


abstract: To explore a novel method to use @entity4 in heavily treated @entity0 , 4-week cycles of high-dosage (280 mg/d) @entity6 were given to 11 asymptomatic @entity0 who had previously received an average of 6 years of @entity3 reverse transcriptase inhibitors (NRTIs). The @entity6 dose was targeted to produce a calculated steady-state concentration of 1.5 microM (336 ng/mL). @entity0 received @entity6 for the first 4 weeks, after which it was discontinued for 4 weeks. Additional 4-week drug cycles were given if plasma @entity5 RNA levels increased to at least 75% of baseline values. The 11 subjects received 38 cycles (average, 3.5 cycles per subject) during the 44-week study. @entity6 was well tolerated. Considering all data, there was a median 0.65 log(10) reduction in viral load as well as a median increase in CD4 cell count of 110/mm3 at the end of the cycles. However, plasma @entity2 increased and CD4 cell counts decreased between cycles. Viral load and CD4 cell responses were similar for up to 4 successive cycles. This suggested that increasing viral resistance was not a problem, as reflected by the acquisition of only one new @entity3 reverse transcriptase mutation among the @entity0 . Significant relationships between @entity6 exposure and changes in plasma @entity1 RNA levels were observed. A similar approach might be considered using a more potent regimen for @entity0 in whom resistance to @entity4 is a major reason for therapeutic failure.

title: Intermittent administration of high-dose @entity6 to XXXX -experienced individuals infected with @entity5 .

answer: @entity3