abstract: BACKGROUND: Left hepatic trisectionectomy (LHT) is a challenging major anatomical hepatectomy with a high complication rate and a worldwide experience that remains limited. The aim of this study was to describe changes in surgical practice over time, to analyse the outcomes of @entity0 undergoing LHT for @entity1 , and to identify factors associated with morbidity and mortality. METHODS: A cohort study was undertaken of @entity0 who underwent LHT at a single tertiary hepatobiliary referral centre between January 1993 and March 2013. Univariable and multivariable analysis was used to identify factors associated with short- and long-term outcomes following LHT. RESULT: Some 113 @entity0 underwent LHT for @entity2 (57), @entity5 (22), @entity6 (12) and @entity4 (11); 11 @entity0 had various other indications. Overall morbidity and 90-day mortality rates were 46  0 and 9  7 per cent respectively. Overall 1- and 3-year survival rates were 71  3 and 44  4 per cent respectively. @entity3 and intraoperative blood transfusion were independent predictors of postoperative morbidity, whereas blood transfusion was the only factor predictive of in-hospital mortality. Time period analysis revealed a decreasing trend in blood transfusion, duration of hospital stay, and postoperative morbidity and mortality in the last 5 years. CONCLUSION: Morbidity, mortality and long-term survival after LHT support its use in selected @entity0 with a significant @entity1 burden.

title: Clinical outcomes of left hepatic trisectionectomy for XXXX .

answer: @entity1


abstract: @entity8 ( @entity8 ) is a novel approach for delivering drugs directly into @entity5 by intracranial infusion, enabling the distribution of high drug concentrations over large tissue volumes. This study was designed to present a method for binding @entity6 ( @entity7 ) to unique crystalline, highly ordered and superparamagnetic maghemite nanoparticles via human serum albumin (HSA) coating, optimized for @entity8 treatments of @entity0 . Naked nanoparticles and HSA- or @entity3 ( @entity4 )-coated nanoparticles with/without @entity7 were studied. In vitro results showed no @entity2 and a similar cell-kill efficacy of the @entity7 -loaded particles via HSA coating to that of free @entity7 , while @entity7 -loaded particles via @entity4 coating showed low efficacy. In vivo, the @entity4 -coated nanoparticles provided the largest distributions in normal @entity1 brain and long clearance times, but due to their low efficacy in vitro, were not considered optimal. The naked nanoparticles provided the smallest distributions and shortest clearance times. The HSA-coated nanoparticles (with/without @entity7 ) provided good distributions and long clearance times (nearly 50% of the distribution volume remained in the brain 3 weeks post treatment). No @entity7 -related @entity2 was noted. These results suggest that the formulation in which HSA was bound to our nanoparticles via a unique precipitation method, and @entity7 was bound covalently to the HSA, could enable efficient and stable drug loading with no apparent @entity2 . The cell-kill efficacy of the bound @entity7 remained similar to that of free @entity7 , and the nanoparticles presented efficient distribution volumes and slow clearance times in vivo, suggesting that these particles are optimal for @entity8 .

title: XXXX of @entity6 -loaded maghemite nanoparticles.

answer: @entity8


abstract: AIM: In this study we investigated sleep and circadian rhythm, functioning and psychopathological symptoms in @entity0 with @entity4 . We looked for answers to the following questions: What percentage of @entity0 with @entity4 after a therapeutic process in the daily psychiatric ward suffers from @entity1 and excessive @entity2 ? What factors influence the functioning of @entity0 with @entity4 . METHODS: 23 @entity0 and 23 healthy controls matched for age and sex (14 @entity0 , 9 @entity0 ; mean age 40.5 +/- 13.66) were examined. All subjects filled out sleep diaries, underwent actigraphy for 7 days, and ratings with scales for the assessment of sleep quality, @entity2 , general clinical state and the degree of improvement, presence and severity of @entity5 , @entity3 . RESULTS: Moderate @entity1 was found in 6 (26%), severe @entity1 in 2 (8%) @entity0 . Four @entity0 (17%) suffered from severe @entity2 . Actigraphy showed a low activity level that had influence on the functioning of @entity0 . The functioning of the @entity0 was most negatively influenced by negative symptoms of @entity4 and @entity3 . Older @entity0 and those who were ill for a longer time presented more @entity3 and they were more @entity5 . The @entity0 spent more time in bed and had longer sleep time than healthy controls. The @entity0 presented highest activity at the time of therapeutic activities. CONCLUSIONS: Despite improvement of psychopathological symptoms, many @entity0 with @entity4 still present low daytime activity and clinically significant @entity1 and/or @entity2 , which deteriorates their functioning.

title: [Sleep and circadian rhythm disturbances in XXXX ].

answer: @entity4


abstract: BACKGROUND: Sleep duration holds considerable importance as an indicator of mental/physical health. The objective of this study was to investigate the association between sleep duration, @entity8 , and @entity4 prevalence in Koreans. METHODS: Of 31,596 subjects eligible for the Korean National Health and Nutrition Examination Survey V (2010-2012), 17,638 @entity0 who answered items on sleep duration (aged >= 19  yrs) were analyzed in a cross-sectional study. Association between sleep duration, @entity8 , and @entity4 prevalence was assessed using logistic regression, and adjusted for various socioeconomic and lifestyle characteristics. RESULTS: Short or long sleep duration showed correlations with @entity8 , and items of significance showed gender-specific patterns. @entity0 displayed significant associations with stress and @entity6 , and @entity0 with stress, thoughts of suicide, and @entity5 counseling. While stress was related with @entity3 in both genders, @entity6 showed a relationship with long duration in @entity0 , and short duration in @entity0 . Prevalence of any @entity4 was associated with  <=6  h sleep when adjusted for factors including @entity8 , and among @entity4 , @entity1 and @entity7 showed associations with @entity3 , while @entity2 and @entity9 were associated with normal sleep duration. CONCLUSIONS: Mental health problems were associated with sleep duration with gender-specific patterns. Associations with @entity7 , @entity1 , @entity2 , @entity9 and @entity3 persisted after adjustment for @entity8 .

title: The association between XXXX , @entity4 and sleep duration in Koreans: a cross-sectional study.

answer: @entity8


abstract: Activation of cannabinoid CB(2) receptors attenuates thermal nociception in untreated animals while failing to produce centrally mediated effects such as @entity4 and @entity6 [Pain 93 (2001) 239]. The present study was conducted to test the hypothesis that activation of CB(2) in the periphery suppresses the development of @entity1 as well as @entity0 -evoked neuronal activity at the level of the CNS. The CB(2)-selective cannabinoid agonist @entity8 (100, 330 micrograms/kg i.p.) suppressed the development of carrageenan-evoked thermal and @entity3 and @entity3 . The @entity8 -induced suppression of carrageenan-evoked behavioral sensitization was blocked by the CB(2) antagonist @entity7 but not by the CB(1) antagonist @entity2 . Intraplantar (ipl) administration of @entity8 (33 micrograms/kg ipl) @entity3 and @entity3 following administration to the carrageenan-injected paw but was inactive following administration in the contralateral (noninflamed) paw, consistent with a local site of action. In immunocytochemical studies, @entity8 suppressed spinal @entity5 protein expression, a marker of neuronal activity, in the carrageenan model of @entity0 . @entity8 suppressed carrageenan-evoked @entity5 protein expression in the superficial and neck region of the dorsal horn but not in the nucleus proprius or the ventral horn. The suppression of carrageenan-evoked @entity5 protein expression induced by @entity8 was blocked by coadministration of @entity7 in all spinal laminae. These data provide evidence that actions at cannabinoid CB(2) receptors are sufficient to suppress @entity0 -evoked neuronal activity at rostral levels of processing in the spinal dorsal horn, consistent with the ability of @entity8 to normalize nociceptive thresholds and produce antinociception in @entity1 states.

title: Selective activation of cannabinoid CB(2) receptors suppresses spinal @entity5 protein expression and @entity1 behavior in a rat model of XXXX .

answer: @entity0


abstract: BACKGROUND: Phosphodiesterases (PDEs) break down @entity1 , thereby regulating intracellular @entity1 concentrations and diffusion. Since @entity6 predominates in airway epithelial cells, @entity6 inhibitors can stimulate @entity9 ( @entity9 ) by increasing @entity1 . @entity2 smoking and @entity4 are associated with decreased @entity9 function and impaired mucociliary clearance (MCC). However, the effects of the @entity6 inhibitor @entity12 on smoke-induced @entity3 have not been fully explored. METHODS: Primary normal @entity0 bronchial epithelial cells (NHBE) from non-smokers, cultured at the air-liquid interface (ALI) were used for most experiments. Cultures were exposed to cigarette smoke in a Vitrocell VC-10 smoking robot. To evaluate the effect of @entity12 on intracellular @entity1 concentrations, fluorescence resonance energy transfer (FRET) between @entity11 (PKA) subunits was recorded. Airway surface liquid (ASL) was measured using light refraction scanning and ciliary beat frequency (CBF) employing infrared differential interference contrast microscopy. @entity7 conductance was measured in Ussing chambers and @entity9 expression was quantified with qPCR. RESULTS: While treatment with 100 nM @entity12 had little effect alone, it increased intracellular @entity1 upon stimulation with @entity5 and @entity8 in cultures exposed to cigarette smoke and in control conditions. @entity1 baselines were lower in smoke-exposed cells. @entity12 prolonged @entity1 increases in smoke-exposed and control cultures. Smoke-induced reduction in functional, @entity8 -mediated @entity7 conductance through @entity9 was improved by @entity12 . ASL volumes also increased in smoke-exposed cultures in the presence of @entity12 while it did not in its absence. Cigarette smoke exposure decreased CBF, an effect rescued with @entity12 , particularly when used together with the long-acting   -mimetic @entity10 . @entity12 also enhanced @entity5 -induced CBF stimulation in ASL volume supplemented smoked and control cells, confirming the direct stimulatory effect of rising @entity1 on ciliary function. In active smokers, @entity9 mRNA expression was increased compared to non-smokers and ex-smokers. @entity12 also increased @entity9 mRNA levels in cigarette-smoke exposed cell cultures. CONCLUSIONS: Our results show that @entity12 can rescue smoke-induced @entity3 by reversing decreased @entity9 activity, augmenting ASL volume, and stimulating CBF, the latter particularly in combination with @entity10 . As expected, @entity9 mRNA expression was not indicative of apical @entity9 function.

title: @entity12 partially reverses smoke-induced XXXX .

answer: @entity3


abstract: PURPOSE: To investigate the efficacy of the Amsler grid test in detecting central @entity1 ( @entity1 ) defects in @entity2 . DESIGN: Prospective, cross-sectional study. @entity0 : @entity0 with @entity2 with reliable Humphrey 10-2 Swedish Interactive Threshold Algorithm standard @entity1 on the date of enrollment or within the previous 3 months. METHODS: Amsler grid tests were performed for each eye and were considered "abnormal" if there was any perceived @entity4 with missing or blurry grid lines within the central 10 degrees ("Amsler grid @entity4 "). An abnormal 10-2 @entity1 was defined as >= 3 adjacent points at P < 0.01 with at least 1 point at P < 0.005 in the same hemifield on the pattern deviation plot. Sensitivity, specificity, and positive and negative predictive values of the Amsler grid @entity4 area were calculated with the 10-2 @entity1 as the clinical reference standard. Among eyes with an abnormal 10-2 @entity1 , regression analyses were performed between the Amsler grid @entity4 area and the 10-2 @entity1 parameters ( @entity5 [ @entity5 ], @entity4 extent [number of test points with P < 0.01 in total deviation map] and @entity4 mean depth [mean sensitivity of test points with P < 0.01 in total deviation map]). MAIN OUTCOME MEASURES: Sensitivity, specificity, and positive and negative predictive values of the Amsler grid @entity4 area. RESULTS: A total of 106 eyes (53 @entity0 ) were included (mean    standard deviation age, 24-2 @entity5 and 10-2 @entity5  = 66  12 years,  -9.61  8.64 decibels [dB] and  -9.75  9.00 dB, respectively). Sensitivity, specificity, and positive and negative predictive values of the Amsler grid test were 68%, 92%, 97%, and 46%, respectively. Sensitivity was 40% in eyes with 10-2 @entity5 better than  -6 dB, 58% in eyes with 10-2 @entity5 between  -12 and  -6 dB, and 92% in eyes with 10-2 @entity5 worse than  -12 dB. The area under the receiver operating characteristic curve of the Amsler grid @entity4 area was 0.810 (95% confidence interval, 0.723-0.880, P < 0.001). The Amsler grid @entity4 area had the strongest relationship with 10-2 @entity5 (quadratic R(2)=0.681), followed by 10-2 @entity4 extent (quadratic R(2)=0.611) and 10-2 @entity4 mean depth (quadratic R(2)=0.299) (all P < 0.001). CONCLUSIONS: The Amsler grid can be used to screen for moderate to severe central @entity3 from @entity2 .

title: Efficacy of the Amsler Grid Test in Evaluating Glaucomatous Central XXXX .

answer: @entity1


abstract: The distribution of glucuronic and @entity6 within the chains of anticoagulantly active and inactive beef lung heparin was investigated. A fraction with an average molecular weight of 19,500 was isolated from the heterodisperse mixture and then separated into active and inactive components by affinity chromatography. Each sample was linked through its reducing terminus to @entity0 , reduced with @entity3 , and bound covalently to Sepharose via an azo bridge. The bound reduced heparin was treated with a limited amount of @entity4 and the degraded fragments were removed. The sections of the chain contiguous with the original reducing terminus were then detached from the insoluble matrix by reaction with @entity1 . The recovered polysaccharide was fractionated according to size on Sephadex G-200 and the amount of each @entity5 in the individual fractions was determined. Inactive heparin showed a constant percentage of @entity2 in all fragments, i.e. about 8.9% of the total @entity5 . With active heparin the percentage of @entity2 increased with the distance from the reducing terminus of the polysaccharide chain, ranging from 9.5 to 20% of the uronic acids. These results suggest that the biosynthesis of active heparin involves unique reactions or specific processing of the macromolecule.

title: Distribution of glucuronic and XXXX units in heparin chains.

answer: @entity6


abstract: PURPOSE: To draw attention to @entity2 which is a rare @entity5 symptom mostly causing wrong diagnosis and delayed treatment. We present nine @entity0 in whom @entity2 was a prominent initial or early ictal symptom. METHODS: We reviewed the records of 4736 @entity0 , and found nine @entity0 who had @entity2 as an aura or an early prominent symptom of their @entity5 . @entity5 semiology, EEG, and cranial imaging features were evaluated retrospectively. RESULTS: Age at @entity5 onset ranged from 6months to 50years, and the mean age during the study was 37.7  11.9years. @entity2 was predominantly peripherally localized in four @entity0 , whereas @entity2 was detected in three @entity0 , and @entity6 was detected in two @entity0 . Electroencephalography (EEG) revealed @entity4 on the temporoparietal and frontotemporal regions in three @entity0 each. Photosensitive generalized @entity4 discharges were detected in one and diffuse background slowing in the remaining two other @entity0 . Electroencephalography abnormalities were lateralized to the contralateral site of the @entity2 in four @entity0 with strictly localized @entity2 . Three @entity0 revealed no abnormality on the cranial MR imaging, whereas others showed different types of abnormality such as @entity7 (n:1), mesial temporal lobe @entity3 (n:1), white and gray matter sequela lesions (n:1), diffuse @entity1 (n:1), chronic @entity9 and @entity8 (n:1), and perivascular space dilatation (n:1). CONCLUSION: @entity2 is a neglected, but important, semiologic symptom with localization and lateralization value in the @entity0 with @entity5 as well as temporal lobe origin. It occurs mainly as peripherally localized, cephalic, or @entity6 and is usually associated with a symptomatic etiology. Awareness of @entity2 is important to avoid misdiagnosis and delayed treatment.

title: Reappraisal of XXXX as a rare symptom of @entity5 .

answer: @entity2


abstract: AIM: To examine the incidence of @entity4 oncogene amplification in clinically localised @entity2 using in situ hybridisation. METHODS: One hundred and seventeen @entity0 , who had undergone radical prostatectomy, were identified and in situ hybridisation was performed on @entity3 fixed, paraffin wax embedded tissue using the Quantum Appligene probe for @entity4 . The enzyme peroxidase was used to detect the probe because this enabled a permanent record to be kept. @entity1 in which there were five or more signals in each nucleus in > 20% of the @entity1 cells were considered to have a significantly increased copy number. A serial section from these @entity1 was then hybridised with the chromosome 17 alpha satellite probe. The ratio of the percentage of cells showing an increase in @entity4 copy number to the number showing polysomy for chromosome 17 was calculated. A ratio above 2 was considered amplified. RESULTS: Biochemical recurrence occurred in 50 (43%) @entity0 and 24 (21%) had clinical recurrence. In situ hybridisation for @entity4 was accessible in 114 (97%) @entity0 . A significant increase in copy number was present in two @entity0 (1.75 %), but chromosome 17 hybridisation showed that the increase was the result of polysomy rather than true amplification. Both these @entity0 had a Gleason score of 7 and stage T3; they also had recurrent clinical disease with distal metastasis within two and 19 months. CONCLUSIONS: Increased @entity4 oncogene copy number appears to be rare in clinically localised @entity2 and is related to chromosome 17 polysomy rather than true amplification. As a result, it would not be a useful biomarker for identifying those @entity0 who will have recurrences after radical prostatectomy.

title: @entity4 oncogene amplification in clinically localised XXXX .

answer: @entity2


abstract: BACKGROUND/AIM: The Fracture Risk Assessment Tool (FRAX score) is the 10-year estimated risk calculation tool for @entity3 that includes clinical data and hip bone mineral density measured by dual-energy x-ray absorptiometry (DXA). The aim of this cross-sectional study was to elucidate the ability of the FRAX score in discriminating between @entity3 positive and negative pre- and postmenopausal @entity0 with @entity4 . METHODS: The bone mineral density (by DXA), thyroid stimulating hormone (TSH) level, free @entity6 (fT4) level, thyroid peroxidase antibodies (TPOAb) titre, osteocalcin and beta-cross-laps were measured in 27 pre- and postmenopausal @entity0 with newly discovered @entity4 [age 58.85 +/- 7.83 years, body mass index (BMI) 27.89 +/- 3.46 kg/m2, menopause onset in 46.88 +/- 10.21 years] and 51 matched euthyroid controls (age 59.69 +/- 5.72 years, BMI 27.68 +/- 4.66 kg/m2, menopause onset in 48.53 +/- 4.58 years). The etiology of subclinical hyperthyroisims was @entity5 or @entity2 . FRAX score calculation was performed in both groups. RESULTS: In the group with @entity4 the main FRAX score was significantly higher than in the controls (6.50 +/- 1.58 vs. 4.35 +/- 1.56 respectively; p = 0.015). The FRAX score for hip was also higher in the evaluated group than in the controls (1.33 +/- 3.92 vs. 0.50 +/- 0.46 respectively; p = 0.022). There was no correlations between low TSH and @entity3 risk (P > 0.05). The ability of the FRAX score in discriminating between @entity3 positive and negative pre- and postmenopausal female subjects (p < 0.001) is presented by the area under the curve (AUC) plotted via ROC analysis. The determined FRAX score cut-off value by this analysis was 6%, with estimated sensitivity and specificity of 95% and 75.9%, respectively. CONCLUSION: Pre- and postmenopausal @entity0 with @entity4 have higher FRAX scores and thus greater risk for low- @entity1 hip @entity3 than euthyroid premenopausal @entity0 . Our results point to the use of FRAX calculator in monitoring pre- and postmenopausal @entity0 with @entity4 to detect subjects with high @entity3 risk in order to prevent further @entity3 .

title: The Fracture Risk Assessment Tool (FRAX score) in XXXX .

answer: @entity4


abstract: The prevalence and yearly incidence of @entity1 between 1 and 16 years of age were studied in a cohort of 16-year-olds, born in 1975, and residing in the County of V  sterbotten, northern Sweden. The study comprised 3007 dental records from the public dental health service. The general distribution was 50.3% @entity0 and 49.7% @entity0 . The records showed that 35% of the @entity0 on one or more occasions had sustained injury to their primary or permanent dentition. The frequency was nearly twice as high for @entity0 (64%) as for @entity0 (36%). Twenty-five percent of the 16-year-olds had met with @entity3 more than once and this group consisted predominantly of @entity0 . The incidence of @entity1 to primary and permanent teeth was 28 per 1000 per year. The @entity0 had sustained @entity1 to their teeth most frequently when they were 4 years of age and between the ages of 8 and 11. This was also true for @entity0 at 4 and at 9 years of age, although less evidently so. In the primary dentition, the majority of @entity3 had affected the supporting tissue of the maxillary incisors. In the permanent dentition, 75% of the traumatised teeth were upper incisors. @entity2 of varying severity constituted 60% of all registered diagnoses in this dentition, followed by subluxation (19%) and concussion (11%).

title: XXXX in a cohort of 16-year-olds in northern Sweden.

answer: @entity1


abstract: This study attempted to determine the failure pattern after radiotherapy for @entity3 using systematic biopsies and serum PSA in assessment of outcome. Between July 1987 and February 1993, 226 @entity0 treated with radical external beam radiotherapy were followed prospectively with systematic transrectal ultrasound-guided biopsies and serum PSA. Four hundred and ten transrectal ultrasound-guided biopsies were performed with 4-7 samples (usually six) per session. Stage distribution was T1b: 32, T1c: 11, T2a: 45, T2b: 62, T3: 50, T4: 6. Median follow-up was 41 months. The rate of positive biopsies continued to decrease over time, reaching a nadir of 30.5% at 30 months post radiotherapy. Local failures have occurred in 17% (38/226) overall, or 13% of T1b, 0% of T1c, 13% of T2a, 20% of T2b and 21% of T3-4. Six additional @entity0 (2.5%) have had biochemical failure and 34 (15%) have biopsy-only failure. Forty seven @entity0 @entity2 on post radiotherapy biopsies (median time 18 months), demonstrated late @entity1 clearance, achieving negative biopsies at a median time of 28 months. Median nadir PSA in @entity0 with no evidence of disease (NED) at last follow-up was 0.5 ng/mL, achieved at 24 months post radiotherapy. For @entity0 with delayed @entity1 clearance, the median nadir PSA was 0.6 ng.mL at 27 months. For those with local failure it was 1.6 ng.mL at 16 months and for all failures, 1.8 ng/mL at 13 months. Systematic prostate biopsies show that @entity1 clearance after radiotherapy may take up to 30 months. @entity1 clearance parallels the fall in serum PSA. Serum PSA nadirs earlier and at a higher value in @entity0 destined to fail.

title: Radiotherapy for XXXX : assessment of results by systematic biopsy and PSA.

answer: @entity3


abstract: Despite an improvement in the surgical management of aortic @entity1 , the observed morbidity and mortality rates remain high. The use of aortic endoprostheses could improve these results, but there are not yet many medium term studies on @entity1 of the isthmus. Between January 2000 and December 2005, we treated endovascularly 9 @entity0 (7 males and 2 females) presenting with a @entity1 of the aortic isthmus, acute in 8 of them and chronic in one case. The average age was 46 years. All of the @entity0 presented with significant traumatic co-morbidity. Ten endoprostheses were used in these 9 @entity0 , and no immediate conversion was necessary. Complete excision of the lesions lasted on average 112 +/- 27 min and there were no per-operative deaths. Hospital mortality was 22% (2 @entity0 : multiple organ failure on day 3, and a CVA on day 10). The mean length of hospital stay was 16 +/- 20 days. The mean follow up of the 7 surviving @entity0 was 38 +/- 17 months. No complications relating to the endoprostheses were reported. In all of the @entity0 an almost complete disappearance of lesions on CT scan was noted: by 6 months for the acute @entity1 and at 1 year for the chronic @entity1 . CONCLUSION: the medium term results of endovascular treatment of @entity1 are good.

title: [Endovascular treatment of aortic XXXX : medium term results].

answer: @entity1


abstract: BACKGROUND: Limited information is available on treatment response of @entity1 in chronic forms of @entity2 . Concurrent @entity1 are @entity2 , but the responsiveness of @entity0 with such comorbidity to different treatments is largely unknown. This study investigated the comparative efficacy of @entity3 , Cognitive Behavioral Analysis System of Psychotherapy (CBASP), and their combination in improving @entity1 in @entity0 with chronic forms of @entity2 , including those with a concurrent @entity1 . METHOD: 681 @entity0 with chronic @entity2 (DSM-IV criteria) participated in a multicenter study of 12 weeks of acute treatment with @entity3 (N = 226), CBASP (N = 228), or the combination (N = 227). The Hamilton Rating Scale for @entity1 (HAM-A), the HAM-A psychic @entity1 factor, and the @entity1 /arousal subscale of the 30-item Inventory for Depressive Symptomatology-Self Report (IDS-SR-30) were used to assess @entity1 . RESULTS: In the full sample. without controlling for change in depressive symptoms, combination therapy was superior to both monotherapies on all 3 @entity1 measures both in the rate of change and at endpoint. When change in depressive symptoms was controlled for, there were no treatment differences in rate of change from baseline to week 12 on any of the 3 @entity1 measures. In those @entity0 with a concurrent @entity1 , however, the combination was superior to CBASP on the HAM-A and the IDS-SR-30. @entity3 alone and combination therapy were both superior to CBASP on the HAM-A psychic @entity1 factor. CONCLUSION: For @entity0 with @entity2 , combination therapy is superior to CBASP or @entity3 alone. Among @entity0 with a concurrent @entity1 , @entity3 . either alone or in combination with CBASP, improves @entity1 faster than CBASP alone, independent of depressive symptom reduction.

title: Symptomatic and syndromal XXXX : effect of @entity3 , cognitive behavioral analysis system of psychotherapy, and their combination.

answer: @entity2


abstract: INTRODUCTION AND AIM: @entity5 ( @entity5 ) is a @entity4 which represents only about 0.2% of all @entity2 . The ratio of female to @entity5 is approximately 100:1. In this study, we review our experience with diagnosis, surgical treatment, and overall management of @entity1 with @entity5 . METHODS: Overall, 5384 @entity0 @entity1 underwent surgery in Masaryk Memorial Cancer Institute, Brno, Czech Republic during the period of 2001 to 2009. Among these, seventeen were @entity1 . In these @entity1 , data on incidence, clinical symptoms, diagnostic procedures, types of surgical resection, histopathology, adjuvant systematic therapy, genetic investigation and therapeutic results were retrospectively reviewed from their medical records. RESULTS: None of the @entity1 have distant metastases at the time of surgery. In sixteen cases an invasive @entity2 was histopathologically diagnosed, one @entity1 had @entity6 ( @entity6 ). Eight @entity1 exhibited locally advanced stage of the disease (IIIB). All @entity1 were primarily treated surgically; in no case neoadjuvant therapy was recommended. From the five @entity1 operated primarily elsewhere, four underwent completion of modified radical mastectomy (RAME) at our institution and one @entity1 underwent subcutaneous (nipple-sparing) mastectomy without the surgery on lymph nodes. Twelve @entity1 were primarily diagnosed and operated at our institution. Ten of these were scheduled for RAME, one @entity1 was recommended total mastectomy with sentinel lymph node biopsy, and one @entity1 underwent total mastectomy without surgery on regional lymph nodes. Adjuvant therapy overall comprised radiotherapy, chemotherapy, hormonal therapy, and biological therapy. Investigation of BRCA genes was suggested in nine @entity1 , but the results of only four of them are available to date. Two @entity1 exhibited a mutation in BRCA genes. One mutation is explicitly pathogenic; another case represents variation with unknown clinical effect. Twelve @entity1 of the cohort are in complete remission, two are alive with distant metastases and three died (two on @entity2 , one on @entity3 ). CONCLUSION: Our study should point out a rare form of @entity0 . There are some particular differences between male and female @entity0 though the overall clinical management of both is generally similar. There is a necessity of appropriate health education to prevent late diagnosis of @entity0 in @entity1 . Genetic testing should be recommended to every male @entity1 with this disease.

title: [ XXXX --our experience].

answer: @entity5


abstract: OBJECT: @entity3 is a rare cause of progressive @entity3 and can be corrected surgically. In most previous reports, closure of the dural defect was the recommended procedure. The object of this paper is to describe a new procedure in which spinal cord constriction is released by enlarging the @entity2 ; additionally the postoperative results will be discussed. METHODS: In nine @entity0 with @entity3 , @entity4 was performed. In eight @entity0 , @entity1 resolved immediately after surgery. In one @entity0 with a severe preoperative @entity1 whose spinal cord herniated massively, deterioration occurred postoperatively. To date, no recurrence of @entity5 has been observed. CONCLUSIONS: The goals of surgery are to reduce the @entity5 , return the spinal cord to the normal position, and prevent the recurrence of @entity5 . The use of sutures to close the dural defect has been the method of choice to date. The surgical space in front of the spinal cord, however, is insufficient to accommodate this procedure safely. Because symptoms are caused by the constriction of the spinal cord at the @entity2 , surgical expansion of the @entity2 allows the goals of surgery to be achieved. This procedure, which is technically easier and less invasive with regard to the vulnerable spinal cord than the closure of the dural defect, could be a viable alternative for the treatment of this rare disease.

title: Surgical management of idiopathic @entity3 : a review of nine cases treated by the XXXX .

answer: @entity4


abstract: UNASSIGNED: Paresthesia-dominant and @entity1 -dominant subgroups have been noted in @entity3 ( @entity3 ), a peripheral @entity4 characterized by altered primary somatosensory/motor (S1/M1) physiology. We aimed to investigate whether brain morphometry dissociates these subgroups. Subjects with @entity3 were evaluated with nerve conduction studies, whereas symptom severity ratings were used to allocate subjects into @entity2 -dominant ( @entity3 - @entity2 ), @entity1 -dominant ( @entity1 ), and @entity1 / @entity2 nondominant (not included in further analysis) subgroups. Structural brain magnetic resonance imaging data were acquired at 3T using a multiecho MPRAGE T1-weighted pulse sequence, and gray matter cortical @entity0 was calculated across the entire brain using validated, automated methods. @entity3 - @entity2 subjects demonstrated reduced median sensory nerve conduction velocity (P = 0.05) compared with @entity1 subjects. In addition, cortical @entity0 in precentral and postcentral gyri (S1/M1 hand area) contralateral to the more affected hand was significantly reduced in @entity3 - @entity2 subgroup compared with @entity1 subgroup. Moreover, in @entity3 - @entity2 subjects, precentral cortical @entity0 was negatively correlated with @entity2 severity (r(34) = -0.40, P = 0.016) and positively correlated with median nerve sensory velocity (r(36) = 0.51, P = 0.001), but not with @entity1 severity. Conversely, in @entity1 subjects, contralesional S1 (r(9) = 0.62, P = 0.042) and M1 (r(9) = 0.61, P = 0.046) cortical @entity0 were correlated with @entity1 severity, but not median nerve velocity or @entity2 severity. This double dissociation in somatotopically specific S1/M1 areas suggests a neuroanatomical substrate for symptom-based @entity3 subgroups. Such fine-grained subgrouping of @entity3 may lead to improved personalized therapeutic approaches, based on superior characterization of the linkage between peripheral and central neuroplasticity.

title: Primary somatosensory/motor cortical @entity0 distinguishes @entity2 -dominant from XXXX .

answer: @entity1


abstract: BACKGROUND: Psoriasis is a chronic recurrent inflammatory skin disease that affects 2-3% of the world population. Biologics are relatively new systemic treatments that block molecular steps important in the pathogenesis of @entity3 . In vivo Reflectance confocal microscopy (RCM) is a non-invasive, imaging technique already reported to be useful in the evaluation of the follow-up of PP under treatment with topical actives and phototherapy. No reports on systemic treatments have been proposed in literature so far. OBJECTIVE: The aim of this study was to evaluate the feasibility of RCM in the monitoring of microscopic response to a subcutaneous anti- @entity2 treatment, Adalimumab. METHODS: One @entity1 with typical clinical aspect, from 48 psoriatic @entity0 , was evaluated using RCM at baseline, after 4 and 8  weeks of treatment. RESULTS: Microscopic confocal changes were followed up during treatment. Results disclosed identification of early microscopic evidence of the anti-inflammatory activity of Adalimumab not detected at clinical examination. Confocal feature related to the effect of @entity2 on melanocytes activity has been also identified. CONCLUSION: Early detected RCM parameters related to Adalimumab activity could be used to identify an early response to the treatment. RCM seems to be able to give useful and practical information about follow-up in @entity0 with PP under treatment with Adalimumab.

title: Reflectance confocal microscopy for plaque @entity3 therapeutic follow-up during an anti- XXXX monoclonal antibody: an observational multicenter study.

answer: @entity2


abstract: @entity2 metabolism leads to the generation of biologically active metabolites that regulate cell growth and proliferation, as well as survival and apoptosis. We have demonstrated previously that @entity3 (LOX) regulates the growth and survival of a number of @entity0 cells. In this study, we show that overexpression of platelet-type 12-LOX in @entity1 @entity5 cells or epithelial @entity0 A431 cells significantly extended their survival and delayed apoptosis when cultured under serum-free conditions. These effects were shown to be a result of enhanced surface integrin expression, resulting in a more spread morphology of the cells in culture. @entity5 cells transfected with 12-LOX displayed increased alpha(v)beta(3) and alpha(v)beta(5) integrin expression, whereas other integrins were unaltered. Transfected A431 cells did not express alpha(v)beta(3); however, alpha(v)beta(5) integrin expression was increased. Treatment of both transfected cell lines with monoclonal antibody to alpha(v)beta(5) (and in the case of @entity5 cells, anti-alpha(v)beta(3)) resulted in significant apoptosis. In addition, treatment with 100 nM @entity6 , the end product of platelet-type 12-LOX, but not other @entity4 , enhanced the survival of wild-type @entity5 and A431 cells and resulted in increased expression of alpha(v)beta(5). Furthermore, @entity7 or @entity8 , specific 12-LOX inhibitors, significantly decreased alpha(v)beta(5)-mediated adhesion and survival in 12-LOX-overexpressing cells. The results show that 12-LOX regulates cell survival and apoptosis by affecting the expression and localization of the vitronectin receptors, alpha(v)beta(3) and alpha(v)beta(5), in two @entity0 cell lines.

title: Overexpression of @entity3 promotes XXXX cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Preoperative glucocorticoid administration has been proposed for reducing postoperative morbidity. This is not widely used before esophageal resection because of incomplete knowledge regarding its effectiveness. The aim here was to assess the effects of preoperative glucocorticoid administration in adults undergoing esophageal resection for @entity5 . METHODS: Studies were identified by searching the Cochrane Controlled Trials Register, MEDLINE, EMBASE, CancerLit, SCIELO and Cochrane Library, and by manual searching from relevant articles. The last search for clinical trials for this systematic review was performed in December 2005. This review included randomized studies of @entity0 with potentially resectable @entity2 of the esophagus that compared preoperative glucocorticoid administration with placebo. Data were extracted by the reviewer, and the trial quality was assessed using Jadad scoring. Odds ratio with 95% confidence limits and bayesian relative risk were used to assess the significance of the difference between the treatment arms. RESULTS: Four randomized trials involving 169 @entity0 were found. There were no differences in postoperative mortality, @entity6 , hepatic and @entity1 between the glucocorticoid and placebo groups. There were fewer @entity3 (95% CI = 0.09-0.46), @entity4 (95% CI = 0.10-0.81), and @entity3 (95% CI = 0.06-0.23) with preoperative glucocorticoid administration. CONCLUSIONS: Prophylactic administration of glucocorticoids is associated with @entity3 .

title: [Use of preoperative glucocorticoid to risk reduction of complications after esophagectomy by XXXX : meta-analysis].

answer: @entity2


abstract: Gac fruit (Momordica cochinchinensis Spreng) is indigenous to Vietnam and other countries in Southeast Asia. Its seed pulp contains high concentrations of carotenoids, especially the provitamin A, @entity4 . In northern Vietnam, gac fruits are seasonal and are mainly used in making a @entity2 dish called xoi gac. The purpose of this study was to develop a method to collect and preserve gac fruit oil, to evaluate the nutritional composition of the oil, and to assess the acceptability of the gac oil by typical Vietnamese homemakers. One hundred @entity0 participated in training to learn how to prepare the fruits and operate the oil press. The @entity0 also participated in a survey of gac fruit use and their habitual use of animal fat and vegetable oil. Among all the @entity0 in the training and surveys, 35 @entity0 actually produced oil from gac fruits grown in the village, using manual oil presses and locally available materials. The total carotene concentration in gac fruit oil was 5,700 micrograms/ml. The concentration of @entity4 was 2,710 micrograms/ml. Sixty-nine percent of total fat was unsaturated, and 35% of that was polyunsaturated. The average daily consumption of gac fruit oil was estimated at 2 ml per @entity0 . The daily @entity4 intake (from gac fruit oil) averaged approximately 5 mg per @entity0 . It was found that gac oil can be produced locally by village @entity0 using manual presses and locally available materials. The oil is a rich source of @entity4 , @entity1 , and essential @entity3 . Although the @entity4 concentration declines with time without a preservative or proper storage, it was still high after three months. The oil was readily accepted by the @entity0 and their @entity0 , and consumption of the oil increased the intake of @entity4 and reduced the intake of lard.

title: A method of preserving and testing the acceptability of gac fruit oil, a good source of @entity4 and essential XXXX .

answer: @entity3


abstract: BACKGROUND: @entity0 with @entity3 ( @entity3 ) have a highly variable occurrence of aortic complications. Aortic tortuosity is often present in @entity3 and may help to identify @entity0 at risk for aortic complications. METHODS: 3D-visualization of the total aorta by MR imaging was performed in 211 adult @entity3 @entity0 (28% with prior aortic root replacement) and 20 controls. A method to assess aortic tortuosity (aortic tortuosity index: ATI) was developed and reproducibility was tested. The relation between ATI and age, and body size and aortic dimensions at baseline was investigated. Relations between ATI at baseline and the occurrence of a clinical endpoint ( @entity2 , and/or aortic surgery) and @entity1 rate during 3years of follow-up were investigated. RESULTS: ATI intra- and interobserver agreements were excellent (ICC: 0.968 and 0.955, respectively). Mean ATI was higher in 28 age-matched @entity3 @entity0 than in the controls (1.92  0.2 vs. 1.82  0.1, p=0.048). In the total @entity3 cohort, mean ATI was 1.87  0.20, and correlated with age (r=0.281, p<0.001), aortic root diameter (r=0.223, p=0.006), and aortic volume expansion rate (r=0.177, p=0.026). After 49.3  8.8months follow-up, 33 @entity0 met the combined clinical endpoint (7 dissections) with a significantly higher ATI at baseline than @entity0 without endpoint (1.98  0.2 vs. 1.86  0.2, p=0.002). @entity0 with an ATI>1.95 had a 12.8 times higher probability of meeting the combined endpoint (log rank-test, p<0.001) and a 12.1 times higher probability of developing an @entity2 (log rank-test, p=0.003) compared to @entity0 with an ATI<1.95. CONCLUSIONS: Increased ATI is associated with a more severe aortic phenotype in @entity3 @entity0 .

title: Increased aortic tortuosity indicates a more severe aortic phenotype in adults with XXXX .

answer: @entity3


abstract: UNASSIGNED: The objective of the present study was to prepare taste-masked mini-tablets, which are easily swallowed dosage forms primarily used by pediatric and geriatric @entity0 . Hot-melt extrusion technology was used to prepare mini-tablets of the bitter model drug @entity2 . @entity3 was used as a taste-masking polymer for the mini-tablets. Thermo gravimetric analysis studies showed that the drug was thermally stable under the employed extrusion parameters. Differential scanning calorimetry and polarized light microscopy-hot stage microscopy studies confirmed that the binary mixtures were miscible under the employed extrusion temperatures. The binary mixtures (10%-50% w/w) were blended and extruded with a 5-mm strand die and cut into consistent mini-tablets by using an adapted downstream pelletizer.In vitro release studies showed that drug release was less than 0.5% within the first 2 min in simulated salivary fluid (pH 6.8) and more than 90% in the first 20 min in gastric media (pH 1.0). The results of the electronic tongue analysis were well correlated with the drug release results obtained for the mini-tablets in artificial saliva. SEM revealed no pores or cracks on the surface of the mini-tablets, confirming that the mini-tablets were compact solids. Fourier transform infrared studies revealed that the @entity1 group in @entity2 had an intermolecular interaction with the carrier. Chemical imaging confirmed the uniform distribution of @entity2 inside the polymer matrices. These results confirmed the excellent suitability of @entity3 for the preparation of novel pediatric and geriatric dosage forms aimed at masking drug taste and improving @entity0 compliance.

title: Preparation and Evaluation of Hot-Melt Extruded XXXX -CentricKetoprofenMini-tablets.

answer: @entity0


abstract: @entity2 in @entity0 can be defined as a binary trait, reflecting presence or absence of @entity1 ( @entity1 ), or as a count variable, number of @entity2 cases (NCM), within a defined time interval. Many different models have been proposed for genetic analyses of @entity2 , and the objective of this study was to evaluate the predictive ability and sire predictions of a set of models for genetic evaluation of @entity1 or NCM. Linear- and threshold liability models for @entity1 , and linear, censored ordinal threshold, and zero-inflated Poisson (ZIP) models for NCM were compared in a cross-validation study. To assess the ability of these models to predict future data, records from 620492 first-lactation Norwegian Red @entity0 , which were daughters of 3064 sires, were evaluated in a fourfold cross-validation scheme. The mean squared error of prediction was used for model comparison. All models but ordinal threshold model equally performed when comparing the overall predictive ability. This result was on average, across sick and healthy @entity0 ; however, the models behaved differently for each category of animals. For example, healthy @entity0 were predicted better by the threshold and linear models for binary data and ZIP model, whereas for mastitic @entity0 , the ordinal threshold model was by far the best model. Predicted sire effects and rankings of sires were highly correlated across all models. For practical purposes, the linear models are very competitive with the nonlinear models.

title: Predictive ability of alternative models for genetic analysis of XXXX .

answer: @entity1


abstract: BACKGROUND _ OBJECTIVES: @entity0 frequently experience @entity1 of moderate to severe degree during gynaecologic procedures. This prospective, randomized, placebo-controlled trial was aimed to investigate the analgesic efficacy of preoperative oral @entity6 , intravenous @entity2 , @entity3 spray, @entity5 and @entity4 on fractional curettage procedure. METHODS: A total of 144 mutiparous @entity0 were randomly allocated to one of the six groups. The first group (control group) consisted of 22 @entity0 and they did not receive any treatment. The second group had 26 @entity0 receiving oral 25 mg @entity6 . The 23 @entity0 of the third group received two puff @entity3 sprays on cervical mucosa. t0 he forth group consisted of 25 @entity0 receiving 100 mg @entity5 . In the fifth group, the 23 @entity0 received 1000 mg intravenous @entity2 and the sixth group consisted of 25 @entity0 receiving @entity4 . RESULTS: @entity5 was the best choice for reducing @entity1 score during curettage procedure (t2:intra-operative). All analgesic procedures were significantly effective in reducing @entity1 during postoperative period (t3). Significant @entity1 reduction was achieved for both intra- and postoperative period by using analgesics. INTERPRETATION _ CONCLUSIONS: The results of our study showed that @entity3 puffs provided the @entity1 relief than the other analgesics used. Therefore, @entity3 may be considered as the first choice analgesic in fractional curettage (NCT ID: 01993589).

title: Effect of XXXX , @entity6 , @entity3 spray, @entity5 _ @entity4 application for @entity1 relief during fractional curettage: A randomized controlled trial.

answer: @entity2


abstract: Five-year survival in @entity0 with unresectable @entity4 ( @entity4 ) is less than 10%. In the present phase II study, 43 @entity0 with locally advanced stage IIIA or selected IIIB @entity4 were given four courses of @entity6 AUC = 6 and @entity5 200 mg/m2 (3-hour infusion), every 3 weeks. Responsive @entity0 , when possible, underwent surgery followed by standard radiotherapy (50 Gy) or radiotherapy (60 Gy), with concurrent @entity3 as intravenous continuous infusion of 4 mg/m2/d. Sixteen of the 42 evaluable @entity0 achieved partial response (38%) and 3 complete response (CR) (7%) for an overall response rate of 45% (95% CI 30.1-60.2). R0 resectability rate was 29%, with 21% of pathologic CRs. Three more CRs were achieved with concurrent chemoradiotherapy in responsive but unresected @entity0 . Grade III/IV hematologic @entity1 was 9%, while one perioperative @entity2 occurred. The median duration of response was 14 months (range: 3-44+); median survival was 15 months (range: 9-47+). One-year and 2-year survival rates were 51% and 22%, respectively. The median survival in the responsive resected @entity0 was 26 months, with 2-year survival of 57%. @entity6 / @entity5 represents an effective and well-tolerated induction therapy, suggesting its possible role in combination with radiotherapy as neoadjuvant treatment in locally advanced @entity4 in alternative to @entity3 -based regimens.

title: Induction chemotherapy with @entity6 / @entity5 followed by surgery or standard radiotherapy and concurrent daily low-dose XXXX for locally advanced @entity4 ( @entity4 ).

answer: @entity3


abstract: The response to treatment and the malignant progression of @entity1 are influenced by the ability of the @entity1 cells to withstand severe @entity7 during prolonged exposure to @entity5 at normal or low extracellular pH (pHe). The objective of the present work was to demonstrate intertumour heterogeneity under conditions of microenvironment-induced @entity7 and to investigate whether the heterogeneity can be attributed to differences in the capacity of the @entity1 cells to generate energy in an @entity2 -deficient microenvironment. Cultures of four @entity0 @entity3 cell lines (BEX-c, COX-c, SAX-c, WIX-c) were exposed to @entity5 in vitro at pHe 7.4, 7.0 or 6.6 for times up to 31 h by using the steel-chamber method. High-performance liquid chromatography was used to assess adenylate energy charge as a function of exposure time. Cellular rates of @entity4 uptake and @entity6 release were determined by using standard enzymatic test kits. The adenylate energy charge decreased with time under @entity5 in all cell lines. The decrease was most pronounced shortly after the treatment had been initiated and then tapered off. BEX-c and SAX-c showed a significantly higher adenylate energy charge under @entity5 conditions than did COX-c and WIX-c whether the pHe was 7.4, 7.0 or 6.6, showing that @entity1 can differ in the ability to avoid @entity7 during microenvironmental stress. There was no correlation between the adenylate energy charge and the rates of @entity4 uptake and @entity6 release. Intertumour heterogeneity in the ability to withstand @entity7 in an @entity2 -deficient microenvironment cannot therefore be attributed mainly to differences in the capacity of the @entity1 cells to generate energy by anaerobic metabolism. The data presented here suggest that the heterogeneity is rather caused by differences in the capacity of the @entity1 cells to reduce the rate of energy consumption when exposed to @entity5 .

title: Energy metabolism in XXXX @entity3 cells under @entity5 and acidic conditions in vitro.

answer: @entity0


abstract: Although surgery remains the mainstay of curative treatment for @entity2 ( @entity2 ), many @entity0 still have high chance to experience disease relapse. It is therefore imperative to identify prognostic markers that can help predict the clinical outcomes of @entity2 . Aberrant microRNA expression holds great potential as diagnostic and prognostic biomarker for @entity2 . Here we aimed to investigate clinical potential of miR-34a-5p as a prognostic marker for @entity2 recurrence and its functional significance. First, we validated that miR-34a-5p was downregulated in @entity2 tissues (P<0.05). The expression level of tissue miR-34a-5p was then evaluated in two independent cohorts of 268 @entity2 @entity0 . miR-34a-5p expression was positively correlated with disease-free survival in two independent cohorts (cohort I: n=205, P<0.001; cohort II: n=63, P=0.006). Moreover, the expression of miR-34a-5p was an independent prognostic factor for @entity2 recurrence by multivariate analysis (P<0.001 for cohort I, P=0.007 for cohort II). Ectopic expression of miR-34a-5p in @entity4 wild-type @entity3 cell HCT116 significantly inhibited cell growth, migration, invasion and @entity1 . miR-34a-5p induced cell apoptosis, cell cycle arrest at G1 phase and @entity4 transcription activity in HCT116 cells, but not in the HCT116 @entity4 knockout ( @entity4 (-/-)) cells. miR-34a-5p significantly suppressed the HCT116 growth in vivo, whereas it showed no effect on the HCT116 @entity4 (-/-) xenograft, indicating that the growth-inhibiting effect by miR-34a-5p was dependent on @entity4 . In addition, the expression level of miR-34a-5p in @entity0 with @entity4 -positive expression was higher than that in @entity0 with @entity4 -negative expression (P<0.01). In conclusion, miR-34a-5p inhibits recurrence of @entity2 through inhibiting cell growth, migration and invasion, inducing cell apoptosis and cell cycle arrest in a @entity4 -dependent manner.Oncogene advance online publication, 3 November 2014; doi:10.1038/onc.2014.348.

title: miR-34a-5p suppresses @entity2 XXXX and predicts recurrence in @entity0 with @entity2 .

answer: @entity1


abstract: BACKGROUND: Existence of true @entity3 has been questioned in recent years. Therefore an @entity3 was analyzed with two new specific markers of lymphatic endothelium. METHODS: Case-report with clinicopathological, immunohistochemical, and ultrastructural findings. A 25-year-old @entity0 presented with recurrent lower lid " @entity2 " and a @entity4 -sized @entity1 palpable in the left lower lid. Magnetic resonance imaging showed an inferonasally located orbital @entity1 which extended to the posterior pole of the eye. The highly vascularized @entity1 was excised by medial orbitotomy. RESULTS: Histopathologically, the mass consisted of large, erythrocyte-filled cavernous vessels without evidence of smooth muscle cells or pericytes surrounding them. Numerous lymph follicles and small arterioles were scattered between them. Immunohistochemically, endothelial cells lining the lumina of the cavernous vessels were partly positive for @entity6 and vascular endothelial growth factor receptor 3 ( @entity5 ), two markers of lymphatic endothelium. These markers did not react with endothelial cells lining the arterioles. Ultrastructurally, cavernous vessels displayed features characteristic of lymphatic vessels, and the smaller vessels demonstrated signs of arterioles. CONCLUSION: Ultrastructural analysis and immunohistochemistry using two new markers of lymphatic endothelium suggest a lymphatic nature of large vessels in an @entity3 . A greater series of @entity1 must be studied with these new lymph endothelial markers to confirm the existence of true @entity3 and to analyze different profiles of lymph endothelial marker expression.

title: @entity3 with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and XXXX ).

answer: @entity6


abstract: BACKGROUND: @entity8 is a rare but serious @entity9 leading to substantial morbidity and early mortality due to @entity6 and @entity3 . The X-linked nature of inheritance accounts for reported differences in phenotypic severity between @entity0 and @entity0 . The rarity of @entity8 has limited understanding of the complete phenotype. Clinical estimates of ages of disease onset and survival based on gender have not been published. METHODS AND RESULTS: We present data on 82 @entity0 with @entity8 from 36 families, the largest series to date. @entity0 were severely affected with @entity1 (100%), @entity7 (88%), and @entity5 (80%). @entity0 had a high morbidity and were unlikely to reach the age of 25 years without a cardiac transplantation. @entity0 were less severely affected but reported higher than expected levels of cognitive (47%) and skeletal muscle complaints (50%) and manifesting an equal prevalence of @entity4 and @entity7 . Combining our data with that of 63 other @entity8 case reports in the literature, the average ages of first symptom, cardiac transplantation, and @entity2 were 12.1, 17.9, and 19.0 years in @entity0 and 27.9, 33.7, and 34.6 years in @entity0 , respectively. CONCLUSION: These data more broadly illuminate the @entity8 phenotype and should prove useful to physicians working with and providing genetic counseling to families with @entity8 . @entity0 with @entity8 present with clinical symptoms and events approximately 15 years after @entity0 and report a higher proportion of cognitive and skeletal muscle problems than previously recognized.

title: Natural history of XXXX .

answer: @entity8


abstract: The @entity4 ( @entity4 ) is the only focus of axillary metastasis in a significant proportion of @entity1 . In this single institutional study, clinicopathologic characteristics were investigated to determine the factors predicting the status of a @entity4 biopsy and the metastatic involvement of non-SLNs. Data were retrospectively reveiwed for 400 consecutive @entity1 with clinical T1/T2 N0 @entity0 who underwent a @entity4 biopsy including axillary and/or internal mammary lymph nodes. The SLNs were evaluated by using the new AJCC staging criteria following multiple sectioning and immunohistochemical (IHC) analyses of nodes. The @entity4 contained @entity2 in 148 @entity1 (38.5%) including 18 @entity1 (12.2%) with micrometastases (<or=0.2 mm) and 130 @entity1 (87.8%) with macrometastases (>0.2 cm). Five @entity1 had @entity3 cells detected by IHC (<or=0.2 mm, N(0i)). @entity1 with @entity3 size more than 2 cm (T1, 29.8% versus T2, 51.6%; OR=2.31, 95% CI, 1.50-3.56) and lymphovascular invasion (LVI-, 30.3% versus LVI+, 51.3%; OR=2.07, 95% CI, 1.34-3.19) were more likely to have positive SLNs in both univariate and multivariate analyses. Among @entity1 with a positive @entity4 biopsy, those with T2 @entity3 (versus T1; 63.1% versus 36.9; OR=2.93, 95% CI, 1.43-6.04), macrometastases in SLNs (versus micrometastases; 88.9% versus 11.1%; OR=8.83; 95% CI, 1.82-42.87) and extracapsular node extension (versus without extracapsular node extension; 65.4% versus 34.6%; OR, 2.23; 95% CI, 1.05-4.72) were more likely to have non- @entity4 @entity2 in both univariate and multivarite analyses. These results indicate that clinicopathologic factors might be helpful to select @entity1 who were less likely to have negative @entity4 or non-SLNs. However, additional factors are still needed to be identified to omit surgical axillary staging.

title: Factors predicting the sentinel and non- @entity4 @entity2 in XXXX .

answer: @entity0


abstract: STUDY DESIGN: A retrospective evaluation of anterior instrumentation of the vertebral bodies in the thoracolumbar spine. OBJECTIVE: To evaluate the possibility of preserving the segmental vessels following anterior instrumentation. SUMMARY OF BACKGROUND DATA: Occlusion of the segmental vessels, routinely performed during anterior spine instrumentation, might cause @entity1 secondary to cord @entity2 . METHODS: The medical data of 29 @entity0 following anterior instrumentation of the vertebral bodies at the thoracolumbar spine were reviewed. All underwent surgery recently when we decided to preserve the segmental vessels whenever possible. We sought the reasons that enabled us to do so regarding age, gender, underlying pathology, surgical technique, operation duration, instrumentation type and size, and location in the vertebral body. RESULTS: In only 7 @entity0 , fused between T10 and L5, were we able to preserve the segmental vessels. All were instrumented with one 6.25-7-mm wide screw in each vertebral body connected by one rod, approximately half the screws above and half below the segmental vessels. In 22 @entity0 , we were unable to preserve the vessels due to the need to insert 2 screws or a large threaded wide vertebral cage into each vertebra. CONCLUSIONS: There is adequate space anteriorly in the vertebral body, above and below the segmental vessels, for the insertion of one screw, even with staples.

title: Avoiding XXXX following ligation of the segmental vessels during anterior instrumentation of the thoracolumbar spine.

answer: @entity1


abstract: BACKGROUND: Mild @entity2 (mTBI) is a common problem in general practice settings, yet previous research does not take into account those who do not attend hospital after injury. This is important as there is evidence that effects may be far from mild. AIM: To determine whether @entity0 sustain any persistent effects 1 year after mTBI, and to identify the predictors of health outcomes. DESIGN AND SETTING: A community-based, longitudinal population study of an mTBI incidence cohort (n = 341) from a mixed urban and rural region (Hamilton and Waikato Districts) of the North Island of New Zealand (NZ). METHOD: Adults (>16 years) completed assessments of cognitive functioning, global functioning, post-concussion symptoms, mood, and quality of life over the year after injury. RESULTS: Nearly half of @entity0 (47.9%) reported experiencing four or more post-concussion symptoms 1 year post-injury. Additionally, 10.9% of @entity0 revealed @entity1 . Levels of @entity3 , @entity5 , or reduced quality of life were comparable with the general population. Having at least one comorbidity, history of @entity6 , living alone, non-white ethnic group, @entity4 and medication use, and being female were significant predictors of poorer outcomes at 12 months. CONCLUSION: Although some @entity0 make a spontaneous recovery after mTBI, nearly half continue to experience persistent symptoms linked to their injury. Monitoring of recovery from mTBI may be needed and interventions provided for those experiencing persistent difficulties. Demographic factors and medical history should be taken into account in treatment planning.

title: Persistent problems 1 year after mild XXXX : a longitudinal population study in New Zealand.

answer: @entity2


abstract: Dietary phytic acid (PA; @entity9 [MI] hexaphosphate) is known to inhibit @entity5 in rodents. Dietary fiber, which is a negative risk factor of @entity5 , improves characteristics of the colonic environment, such as the content of organic acids and microflora. We hypothesized that dietary PA would improve the colonic luminal environment in @entity1 fed a high-fat diet. To test this hypothesis, @entity1 were fed diets containing 30% beef tallow with 2.04% @entity6 PA, 0.4% MI, or 1.02% @entity6 PA + 0.2% MI for 3 weeks. Compared with the control diet, the @entity6 PA diet up-regulated cecal organic acids, including @entity4 , @entity8 , and @entity7 ; this effect was especially prominent for cecal butyrate. The sodium PA + MI diet also significantly increased cecal butyrate, although this effect was less pronounced when compared with the @entity6 PA diet. The cecal ratio of Lactobacillales, cecal and fecal mucins (an index of intestinal barrier function), and fecal b-glucosidase activity were higher in @entity1 fed the @entity6 PA diet than in those fed the control diet. The sodium PA, MI, and sodium PA + MI diets decreased levels of serum @entity0 @entity2 factor a, which is a proinflammatory cytokine. Another proinflammatory cytokine, serum @entity3 , was also down-regulated by the @entity6 PA and sodium PA + MI diets. These data showed that PA may improve the composition of cecal organic acids, microflora, and mucins, and it may decrease the levels of serum proinflammatory cytokines in @entity1 fed a high-fat, mineral-sufficient diet.

title: Dietary phytic acid modulates characteristics of the colonic luminal environment and reduces serum levels of proinflammatory cytokines in XXXX fed a high-fat diet.

answer: @entity1


abstract: BACKGROUND: @entity1 (COX-2)-specific inhibitors are marketed as safer analgesics than non-selective non-steroidal anti-inflammatory drugs. However, there has been conflicting evidence concerning endothelial function and cardiovascular risk after COX-2 inhibitor use. We investigated forearm skin vascular reactivity to brief axillary @entity0 in healthy volunteers after a single dose of the non-steroidal anti-inflammatory drugs @entity2 (non-selective) and @entity3 (COX-2 specific). METHODS: Ten healthy male volunteers were studied. Forearm skin blood flow was measured using laser Doppler flowmetry. Two non-invasive probes were placed on the volar surface of the forearm. The magnitude of hyperaemic response to brief (20 s) and prolonged (5 min) occlusion of the axillary artery was measured before and 2-3 h after administration of @entity2 800 mg or @entity3 25 mg. The transient hyperaemic response ratio (THRR), defined as the net peak hyperaemic flow-flux divided by the net baseline flow-flux, was calculated. Each volunteer received both drugs in random order at least 1 week apart. RESULTS: @entity2 and @entity3 increased net baseline blood flow (median (range): @entity2 , from 23.3 (12.1-40.8) to 31.5 (17.4-77.3); @entity3 , from 22.0 (14.6-41.0) to 29.9 (19.5-112.0); P<0.01). The net hyperaemic peak flow-flux after brief and prolonged occlusion was unchanged after both drugs. THRR was reduced by both drugs ( @entity2 , from 2.92 (2.38-3.86) to 2.09 (1.45-3.54); @entity3 , from 3.36 (2.06-5.16) to 2.67 (1.15 -3.84); P<0.01). CONCLUSIONS: Both COX-2 and non-selective non-steroidal anti-inflammatory drugs, when given to healthy volunteers as single therapeutic doses, decrease skin microvascular tone but do not impair maximal vasodilatory ability.

title: Non-selective and XXXX -specific non-steroidal anti-inflammatory drugs impair the hyperaemic response of skin to brief axillary @entity0 .

answer: @entity1


abstract: OBJECTIVES: We hypothesized that @entity2 ( @entity6 ) might alter the beneficial effect of beta-blockers on left ventricular ejection fraction (LVEF) in @entity0 with @entity4 . BACKGROUND: @entity2 blunts the vasodilation caused by both @entity7 ( @entity7 ) inhibitors and beta-blockers in @entity1 @entity0 and in @entity0 with @entity4 . Several studies suggest that @entity6 also blunts some of beneficial effects of @entity7 inhibitors on mortality in @entity0 with @entity4 . To our knowledge, there have been no data evaluating the possible interaction of @entity6 and beta-blockers on left ventricular remodeling in @entity0 with @entity4 . METHODS: We retrospectively evaluated @entity0 entered into the Multicenter Oral @entity8 Heart failure Assessment (MOCHA) trial, a 6-month, double-blind, randomized, placebo-controlled, multicenter, dose-response evaluation of @entity8 in @entity0 with chronic stable symptomatic @entity4 . Multivariate analysis was performed to determine if @entity2 independently influenced the improvement in LVEF. RESULTS: Over all randomized @entity0 (n = 293), LVEF improved 8.2 +/- 0.8 ejection fraction (EF) units in @entity6 nonusers and 4.5 +/- 0.7 EF units in @entity6 users (p = 0.005). In subjects randomized to treatment with @entity8 (n = 231), LVEF improved 9.5 +/- 0.9 EF units in @entity6 nonusers and 5.8 +/- 0.8 EF units in @entity6 users (p = 0.02). In subjects randomized to treatment with placebo (n = 62), LVEF improved 2.8 +/- 1.2 EF units in @entity6 nonusers and 0.5 +/- 1.4 EF units in @entity6 users (p = 0.20). @entity2 did not significantly affect the heart rate or systolic blood pressure response in either the placebo or @entity8 groups. The effect of @entity6 became more significant on multivariate analysis. The change in LVEF was also influenced by @entity8 dose, etiology of @entity4 , baseline heart rate, EF and @entity5 use. The detrimental effect of @entity6 on the improvement in LVEF was dose-related and was present in both placebo and @entity8 groups, although the effect was statistically significant only in the much larger @entity8 group. CONCLUSIONS: @entity2 significantly affects the changes in LVEF over time in @entity0 with @entity4 and @entity3 treated with @entity8 . The specific mechanism(s) underlying this interaction are unknown and further studies are needed to provide additional understanding of the molecular basis of factors influencing reverse remodeling in @entity0 with @entity4 .

title: XXXX impairs reverse myocardial remodeling in @entity0 with @entity4 treated with beta-blockers.

answer: @entity2


abstract: AIM: To investigate the effects of activated @entity0 hepatic stellate cells (HSCs) on @entity0 Th1/Th2 profile in vitro. METHODS: Growth and survival of activated HSCs and @entity1 (+) T lymphocytes cultured alone or together was assessed after 24 or 48 h. @entity1 (+) T lymphocytes were then cultured with or without activated HSCs for 24 or 48 h and the proportion of Th1 [interferon (IFN)-y(+)] and Th2 [interleukin (IL)-4(+)] cells was assessed by flow cytometry. Th1 and Th2 cell apoptosis was assessed after 24 h of co-culture using a caspase-3 staining procedure. Differentiation rates of Th1 and Th2 cells from @entity1 (+) T lymphocytes that were positive for CD25 but did not express IFN-y or @entity2 were also assessed after 48 h of co-culture with activated HSCs. Galectin-9 expression in HSCs was determined by immunofluorescence and Western blotting. ELISA was performed to assess galectin-9 secretion from activated HSCs. RESULTS: Co-culture of @entity1 (+) T lymphocytes with activated @entity0 HSCs for 48 h significantly reduced the proportion of Th1 cells compared to culture-alone conditions (-1.73%    0.71%; P < 0.05), whereas the proportion of Th2 cells was not altered; the Th1/Th2 ratio was significantly decreased (-0.44    0.13; P < 0.05). In addition, the level of IFN-y in Th1 cells was decreased (-65.71    9.67; P < 0.01), whereas the level of @entity2 in Th2 cells was increased (82.79    25.12; P < 0.05) by co-culturing, as measured by mean fluorescence intensity by flow cytometry. Apoptosis rates in Th1 (12.27%    0.99%; P < 0.01) and Th2 (1.71%    0.185%; P < 0.01) cells were increased 24 h after co-culturing with activated HSCs; the Th1 cell apoptosis rate was significantly higher than in Th2 cells (P < 0.01). Galectin-9 protein expression was significantly decreased in HSCs only 24 h after co-culturing (P < 0.05) but not after 48 h. Co-culture for 48 h significantly increased the differentiation of Th1 and Th2 cells; however, the increase in the proportion of Th2 cells was significantly higher than that of Th1 cells (1.85%    0.48%; P < 0.05). CONCLUSION: Activated @entity0 HSCs lower the Th1/Th2 profile, inhibiting the Th1 response and enhancing the Th2 response, and this may be a novel pathway for liver fibrogenesis.

title: Activated XXXX hepatic stellate cells influence Th1/Th2 profile in vitro.

answer: @entity0


abstract: OBJECTIVE: To investigate the combined treatment of surgery and radiotherapy as well as prognosis significance for advanced @entity1 . METHODS: Fourty-three cases of advanced @entity1 treated by surgery and pre- and post-operative radiation were retrospectively analysed. Twenty-nine @entity0 were treated by preoperative radiotherapy with surgery, fourteen by surgery with postoperative irradiation. 43 @entity0 were underwent radical vulvectomy with inguinal lymphadenectomy (20 cases) and with biopsies of inguinal lymph nodes (16 cases). Partial resection of vagina, distant urethra or anus were done concurrently with radical vulvectomy in 41 @entity0 with adjacent organs invaded. The effects with various doses of radiation for local @entity1 were compared and the recurrences in @entity0 with @entity1 resected completely and with @entity2 after surgery were analysed. RESULTS: The overall 5-yr survival rate was 45.0% for this group (by Kaplan-Meier). @entity0 received preoperative irradiation with dose maximum (Dm) > or = 40 Gy had a better @entity1 regression than with Dm < 40 Gy (75.0% vs 18.2%, P < 0.05). 4 out of 6 @entity0 received postoperative irradiation Dm > 40 Gy were survived over 5-yr, in contrast, 2 out of 8 @entity0 with Dm < or = 40 Gy were survived over 3 and 5 years respectively. The local recurrence rate was 25.0% in @entity0 with no residual disease and 68.4% with microscopic @entity1 in the surgical margins or nearby (P < 0.05). CONCLUSION: The results demonstrate that the dosage of irradiation and the thoroughness of radical surgery are the most important factors influencing the prognosis.

title: [Combined treatment for advanced XXXX ].

answer: @entity1


abstract: UNASSIGNED: Angiogenesis denotes the formation of new blood vessels from pre-existing vasculature. Progression of diseases such as @entity0 and several @entity2 may be promoted by excess angiogenesis. Novel therapeutics to inhibit angiogenesis and diagnostic tools for monitoring angiogenesis during therapy, hold great potential for improving treatment of such diseases. We have previously generated so-called biparatopic Affibody constructs with high affinity for the @entity3 ( @entity3 ), which recognize two non-overlapping epitopes in the ligand-binding site on the receptor. Affibody molecules have previously been demonstrated suitable for imaging purposes. Their small size also makes them attractive for applications where an alternative route of administration is beneficial, such as topical delivery using eye drops. In this study, we show that decreasing linker length between the two Affibody domains resulted in even slower dissociation from the receptor. The new variants of the biparatopic Affibody bound to @entity3 -expressing cells, blocked @entity1 binding, and inhibited @entity1 -induced signaling of @entity3 over expressing cells. Moreover, the biparatopic Affibody inhibited sprout formation of endothelial cells in an in vitro angiogenesis assay with similar potency as the bivalent monoclonal antibody ramucirumab. This study demonstrates that the biparatopic Affibody constructs show promise for future therapeutic as well as in vivo imaging applications.

title: Novel affinity binders for neutralization of XXXX ( @entity1 ) signaling.

answer: @entity1


abstract: Entry of influenza virus into the host cell is dependent on the fusion of the viral envelope with the endosomal membrane and is mediated by a low-pH-induced change of the viral hemagglutinin (HA) to a conformation that is fusogenic. A compound related to @entity3 (180299) was identified that inhibits multicycle replication of influenza A/Kawasaki/86 (H1N1) virus in culture. Treatment of Madin-Darby @entity1 kidney (MDCK) cells with 180299 at 1 h before infection resulted in the inhibition of viral protein synthesis. Addition of 20 microgram of 180299/ml at 1 h p.i. had no effect, indicating that 180299 affects an early step of the influenza viral replication cycle. Genetic analysis of reassortants between sensitive and resistant viruses demonstrated that hemagglutinin (HA) conferred the 180299-resistant (180299(r)) phenotype. Twelve independent isolates of influenza A/Kawasaki/86 were selected for resistance to 180299, and sequence analysis revealed that each of these viruses contained @entity2 substitutions in the HA. These mutations are dispersed throughout the HA primary @entity2 sequence and cluster in one of two regions: the interface between HA1 and HA2 and in a region near the fusion domain of HA2. When compared with the parent virus, the pH-of-inactivation of the resistant mutants was increased by 0.3 to 0.6 pH unit, suggesting that the mutant HAs undergo the conformational change at an elevated pH. Fusion of @entity0 erythrocytes to MDCK cells infected with parent influenza A/Kawasaki/86 was inhibited by 180299 (0.1-10 microgram/ml) in a concentration-dependent manner, whereas fusion of erythrocytes to MDCK cells infected with 180299(r) mutants was not affected. These results suggest that 180299 interacts with the neutral pH conformation of influenza A HA and prevents the low-pH-induced change of HA to its fusogenic conformation.

title: Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to XXXX .

answer: @entity3


abstract: PURPOSE: Standard therapies for localized inoperable @entity5 ( @entity5 ) are ineffective. Advances in radiotherapy (RT) techniques and image guidance have enabled ablative doses to be delivered to large @entity2 . This study evaluated the effects of RT dose escalation in the treatment of @entity5 . @entity0 AND METHODS: Seventy-nine consecutive @entity0 with inoperable @entity5 were identified and treated with definitive RT from 2002 to 2014. At diagnosis, the median @entity1 size was 7.9 cm (range, 2.2 to 17 cm). Seventy @entity0 (89%) received systemic chemotherapy before RT. RT doses were 35 to 100 Gy (median, 58.05 Gy) in three to 30 fractions for a median @entity6 ( @entity6 ) of 80.5 Gy (range, 43.75 to 180 Gy). RESULTS: Median follow-up time for @entity0 alive at time of analysis was 33 months (range, 11 to 93 months). Median @entity4 ( @entity4 ) time after diagnosis was 30 months; 3-year @entity4 rate was 44%. Radiation dose was the single most important prognostic factor; higher doses correlated with an improved local control (LC) rate and @entity4 . The 3-year @entity4 rate for @entity0 receiving @entity6 greater than 80.5 Gy was 73% versus 38% for those receiving lower doses (P = .017); 3-year LC rate was significantly higher (78%) after a @entity6 greater than 80.5 Gy than after lower doses (45%, P = .04). @entity6 as a continuous variable significantly affected LC (P = .009) and @entity4 (P = .004). There were no significant treatment-related @entity3 . CONCLUSION: Delivery of higher doses of RT improves LC and @entity4 in inoperable @entity5 . A @entity6 greater than 80.5 Gy seems to be an ablative dose of RT for large IHCCs, with long-term survival rates that compare favorably with resection.

title: Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in XXXX With Inoperable @entity5 : A Retrospective Dose Response Analysis.

answer: @entity0


abstract: Using the @entity0 ( @entity0 ) two-hybrid system and a @entity1 ( @entity1 ) KNOX protein, designated @entity8 , as bait, we have identified seven distinct interacting proteins from a stolon library of @entity1 . All seven cDNAs are members of the BEL1-like family of transcription factors. Among these proteins, there are at least four regions of high sequence conservation including the homeodomain, the @entity6 - @entity3 - @entity6 three- @entity2 loop extension, the SKY box, and a 120- @entity2 region upstream from the homeodomain. Through deletion analysis, we identified a protein-binding domain present in the @entity5 end of the KNOX domain of @entity8 . The protein-binding domain in the BEL1 protein is located in the @entity4 -terminal one-half of the 120-residue conserved region of the BELs. RNA-blot analysis showed differential patterns of RNA accumulation for the BELs in various @entity1 organs. The level of @entity7 mRNA increased in response to a short-day photoperiod in both leaves and stolons. Similar to sense mutants of @entity8 , transgenic lines that overexpressed @entity7 exhibited enhanced tuber formation even under noninductive conditions. Unlike @entity8 sense lines, however, these BEL lines did not exhibit the extreme leaf and stem morphology characteristic of KNOX overexpressers and displayed a more rapid rate of growth than control plants. Both @entity7 and @entity8 sense lines exhibited an increase in cytokinin levels in shoot tips. @entity7 lines also exhibited a decrease in the levels of GA 20-oxidase1 mRNA in stolon tips from long-day plants. Our results demonstrate an interaction between KNOX and BEL1-like transcription factors of @entity1 that may potentially regulate processes of development.

title: Interacting transcription factors from the three- XXXX loop extension superclass regulate tuber formation.

answer: @entity2


abstract: BACKGROUND: The increased risk of second @entity1 , including nonmelanoma @entity5 , in @entity3 ( @entity3 ) @entity0 has been well documented. However, relatively few studies of @entity2 in @entity3 @entity0 have been reported. METHODS: A database of 250 @entity3 @entity0 registered over a 3-year period was searched to identify @entity0 with diagnoses of both @entity7 ( @entity7 ) and @entity2 . RESULTS: We identified six cases of @entity7 associated with @entity2 and one associated with @entity8 , which is a marker of increased risk of @entity2 . In four @entity0 , @entity2 was diagnosed along with or before @entity7 . In the remaining two @entity0 , @entity7 was diagnosed prior to @entity2 , although @entity8 were noted at the time @entity7 was diagnosed. These two @entity0 received treatment for their @entity7 (one with topical @entity6 mustard and another with radiation therapy and @entity6 mustard) prior to the histologic confirmation of @entity2 . Six @entity0 had early stages of @entity7 (IA or IB), while one @entity0 presented with simultaneous @entity7 involving the lymph nodes as well as @entity2 metastatic to the lymph nodes from an unknown primary. CONCLUSION: There is an elevated prevalence of @entity2 in @entity7 @entity0 compared to the general US population (P < 0.00001) with a relative risk of 15.3 for observing @entity2 in @entity7 @entity0 (95% confidence interval 7.0-33.8). Possible pathologic links between the two diagnoses include effects of @entity7 therapies, immunosuppression secondary to @entity7 , and genetic alterations in the @entity4 @entity1 suppressor protein.

title: Mycosis fungoides associated with XXXX and @entity8 .

answer: @entity2


abstract: PURPOSE: The purpose of this study was to determine the frequency of @entity2 (+)CD25(+) @entity1 (+) regulatory T cells (Treg) in the peripheral blood of @entity0 with childhood chronic @entity4 ( @entity4 ) exhibiting @entity3 and spontaneous remission. The findings of this study indicate the possibility of predicting spontaneous recovery and pathogenesis of childhood chronic @entity4 . METHODS: Eleven @entity0 with chronic @entity4 (seven @entity3 and four spontaneous remission cases; mean age, 8.8 years; range, 1.7-14.9 years) were enrolled in this study. Five healthy @entity0 and eight healthy adults were included as controls. The frequency of Treg was evaluated by flow cytometry in the peripheral blood. RESULTS: In this study, four @entity0 (36%) achieved spontaneous remission within 2.8 years (mean year; range, 1.0-4.4 years). The frequency of Treg was significantly lower in @entity0 with persisting @entity3 (0.13%  0.09%, P<0.05), than that in the @entity0 with spontaneous remission (0.30%  0.02%), healthy adults controls (0.55%  0.44%), and healthy @entity0 controls (0.46%  0.26%). A significantly positive correlation was found between the frequency of Treg and the platelet count in @entity0 . CONCLUSION: These data suggest that a lower frequency of Treg contributes to the breakdown of self-tolerance, and may form the basis for future development of specific immunomodulatory therapies. Furthermore, Treg frequency has prognostic implication toward the natural course and long-term outcomes of childhood chronic @entity4 .

title: Association of @entity2 (+)CD25(+) XXXX (+) regulatory T cells with natural course of childhood chronic @entity4 .

answer: @entity1


abstract: BACKGROUND: Magnetic resonance imaging (MRI) allows precise detection of intracranial lesions in head injured @entity0 . We compared intracranial lesions detected in MRI to somatosensory evoked potentials (SEP) and brainstem auditory evoked potentials (BAEP) concerning their prognostic value. METHODS: Thirty @entity0 with @entity2 and prolonged recovery were studied. Size, side and number of 474 intra- and extraparenchymal lesions as well as lesion localisation based on a specific anatomical classification were entered into a database (a total of 7080 data). In addition, we recorded median-nerve SEP (M-SEP), tibial nerve SEP (T-SEP) and BAEP in all of the @entity0 . FINDINGS: M-SEP and Glasgow-Outcome-Score (GOS) one year after injury correlated significantly to @entity0 with lesions in the brainstem (p<0.0001) and corpus callosum (p<0.001). Similar results were found for T-SEP (p<0.0001). All @entity0 with bicortical loss of M-SEP had an unfavourable outcome (GOS 2). Among the analysis of lesion volume, only the volume of @entity1 correlated to GOS (p<0.001), but this was not found for @entity1 . However, comparing the vegetative (GOS 2) to the non-vegetative group ( @entity4 -5), for both callosal (p<0.02) and brainstem (p<0.005) lesions a significant correlation was found. INTERPRETATION: MRI does not improve the prognostic reliability of SEP in @entity3 but offers possibilities for clarifying electrophysiological and clinical pathologies. This explains that the volume of @entity1 , essentially influencing the clinical outcome, is strongly correlated to T-SEP and M-SEP. In contrast, @entity1 did not show a clear relationship to outcome despite large @entity1 (>4 ml) which tended to poor outcome. In conclusion, we suggest that MRI and SEP are supplementary to each other concerning prognostic evaluation.

title: Evoked potentials in acute head injured XXXX with MRI-detected intracerebral lesions.

answer: @entity0


abstract: PURPOSE: To evaluate the magnetic susceptibility properties of different anatomical structures within the knee joint using quantitative susceptibility mapping (QSM). METHODS: A collagen tissue model was simulated and ex vivo animal cartilage experiments were conducted at 9.4 Tesla (T) to evaluate the B0 orientation-dependent magnetic susceptibility contrast observed in cartilage. Furthermore, nine volunteers (six healthy subjects without knee @entity1 history and three @entity0 with known @entity5 , between 29 and 58 years old) were scanned using gradient-echo acquisitions on a high-field 7T MR scanner. Susceptibility values of different tissues were quantified and diseased cartilage and meniscus were compared against that of healthy volunteers. RESULTS: Simulation and ex vivo animal cartilage experiments demonstrated that collagen fibrils exhibit an anisotropic susceptibility. A gradual change of magnetic susceptibility was observed in the articular cartilage from the superficial zone to the deep zone, forming a multilayer ultrastructure consistent with anisotropy of collagen fibrils. @entity3 caused a clear reduction of susceptibility contrast between the injured meniscus and surrounding cartilage illustrated by a loss of the sharp boundaries between the two. Moreover, QSM showed more dramatic contrast in the focal @entity2 than R2* mapping. CONCLUSION: The arrangement of the collagen fibrils is significant, and likely the most dominant source of magnetic susceptibility anisotropy. Quantitative susceptibility mapping offers a means to characterize magnetic susceptibility properties of tissues in the knee joint. It is sensitive to collagen damage or degeneration and may be useful for evaluating the status of knee diseases, such as @entity3 and @entity4 . Magn Reson Med, 2017.    2017 International Society for Magnetic Resonance in Medicine.

title: Investigating magnetic susceptibility of XXXX knee joint at 7 tesla.

answer: @entity0


abstract: UNASSIGNED: Although under-diagnosed, @entity2 and @entity3 are among the most prevalent @entity1 in @entity0 and adolescents, leading to severe impairment, increased risk of future @entity1 problems, and a high economic burden to society. Universal prevention may be a potent way to address these widespread problems. There are several benefits to universal relative to targeted interventions because there is limited knowledge as to how to screen for @entity2 and @entity3 in the general population. Earlier meta-analyses of the prevention of @entity3 and @entity2 among @entity0 suffer from methodological inadequacies such as combining universal, selective, and indicated interventions in the same analyses, and comparing cluster-randomized trials with randomized trials without any correction for clustering effects. The present meta-analysis attempted to determine the effectiveness of universal interventions to prevent @entity2 and @entity3 after correcting for clustering effects. A systematic search of randomized studies in PsychINFO, Cochrane Library, and Google Scholar resulted in 30 eligible studies meeting inclusion criteria, namely peer-reviewed, randomized or cluster-randomized trials of universal interventions for @entity2 and @entity3 in school-aged @entity0 . Sixty-three percent of the studies reported outcome data regarding @entity2 and 87  % reported outcome data regarding @entity3 . Seventy percent of the studies used randomization at the cluster level. There were small but significant effects regarding @entity2 (.13) and @entity3 (.11) symptoms as measured at immediate posttest. At follow-up, which ranged from 3 to 48  months, effects were significantly larger than zero regarding @entity3 (.07) but not @entity2 (.11) symptoms. There was no significant moderation effect of the following pre-selected variables: the primary aim of the intervention ( @entity2 or @entity3 ), deliverer of the intervention, gender distribution, @entity0 's age, and length of the intervention. Despite small effects, we argue for the possible clinical and practical significance of these programs. Future evaluations should carefully investigate the moderators and mediators of program effects to identify active program components.

title: Universal Prevention for @entity3 in XXXX : A Meta-analysis of Randomized and Cluster-Randomized Trials.

answer: @entity0


abstract: BACKGROUND: @entity3 is prevalent among @entity1 and associated with reduced quality of life, and therefore it is important to determine its incidence in adult @entity1 , especially in those with @entity0 . OBJECTIVE: To determine the occurrence of @entity3 in @entity1 who underwent conservative surgery for @entity0 with or without breast reconstruction. METHODS: Seventy-five @entity1 aged between 18 and 65 years were enrolled. @entity1 had undergone conservative surgery for @entity0 with immediate breast reconstruction (n = 25) or without breast reconstruction (n = 25) at least one year before the study. The control group consisted of 25 @entity1 without @entity2 , but of similar age and educational level distribution as the other two groups. The Beck @entity3 Inventory was used to measure @entity3 . The collected data were assessed using analysis of variance and the      test. RESULTS: There were no significant differences between groups in age (p = 0.72) or educational level (p = 0.20). A smaller number of @entity1 had undergone the menopause (p = 0.02) in the control group than in other groups. There were no significant differences in occurrence of @entity3 between groups (     = 9.97; p = 0.126). CONCLUS  ON: Conservative surgery for @entity0 did not affect the occurrence of @entity3 in @entity1 , regardless of whether breast reconstruction was performed.

title: XXXX and conservative surgery for @entity0 .

answer: @entity3


abstract: BACKGROUND: The purpose of this study was to review our experiences treating @entity1 ( @entity1 ) by common femoral artery endarterectomy (CFE) with and without endovascular therapy (EVT), and to describe the role of CFE in the endovascular @entity2 . METHODS: We retrospectively reviewed a contemporary series of 38 limbs from January 2010 to September 2014. Clinical outcomes of primary patency, assisted primary patency, limb salvage, and survival were analyzed with the Kaplan-Meier method. Multivariable perioperative predictors of primary patency were identified using the stepwise Cox proportional hazards regression model. RESULTS: Hemodynamic success was achieved in 36 of the 38 limbs (95%). The mean ankle brachial pressure index improved significantly, rising from 0.56    0.04 preoperatively to 0.89    0.04 postoperatively (P = 0.0001). Overall primary and assisted primary patency rates, respectively, were 90% and 100% at 12 months and 85% and 94% at 24 months. There was no significant difference in primary patency rate between isolated CFE and hybrid CFE plus EVT. Both limb salvage and survival rates were 97% at 12 months and 97% at 24 months. Multivariate Cox regression analysis revealed that no clinical or perioperative risk factors were predictive of decreased primary patency. CONCLUSIONS: CFE is a safe, effective, and durable procedure for common femoral @entity0 , and hybrid CFE plus EVT can be a valid alternative to open surgical bypass for multilevel occlusive @entity0 . These observations stress that CFE plays a vital role in the management of @entity1 even in the endovascular @entity2 .

title: The Role of Common Femoral Artery Endarterectomy in the Endovascular XXXX .

answer: @entity2


abstract: BACKGROUND: The guidelines for digital @entity3 (DUs) management in @entity2 ( @entity2 ) indicate the use of iloprost to induce wound healing and @entity4 to prevent the onset of new DU. The aim of our study was to evaluate whether the combination treatment may surmount the effect of the single drug. METHODS: We analyzed data regarding 34 @entity0 with @entity2 and at least one active DU persisting despite 6 months of iloprost therapy, and treated for other 6 months with a combination therapy, i.e. iloprost plus @entity4 . RESULTS: Overall, @entity0 initially presented 69 DUs (58 on the fingers and 11 on the legs). At the end of the study 34 (49.3%) DUs were completely healed (responding, R), 18 (26.1%) started the healing process (partially responding, PR), and 17 (24.6%) did not respond (NR) to therapy. No new DU was recorded and the @entity3 localized on the legs did not respond to the combination therapy. Finally, data have been analyzed by dividing the @entity0 in two groups according to the @entity1 level on the finger. In the group with mild @entity1 , 83.4% of DUs resulted with showing complete healing while, in the group with severe @entity1 , only 18% of DUs were healed (P = 0.024). CONCLUSION: The treatment with iloprost plus @entity4 is effective in determining healing of DUs in @entity2 @entity0 with mild @entity1 . Conversely, the severity of skin @entity1 strongly influences the healing process of DUs. The study confirmed the efficacy of @entity4 to prevent onset of new DUs.

title: Digital @entity3 in scleroderma XXXX : A retrospective observational study.

answer: @entity0


abstract: UNASSIGNED: Our previous studies showed oral gavage of @entity14 (AFG1) induced @entity10 in NIH @entity1 . We recently found that a single intratracheal administration of AFG1 caused chronic inflammatory changes in @entity3 alveolar septum. Here, we examine whether oral gavage of AFG1 induces @entity4 and how it contributes to @entity5 . We evaluated chronic lung inflammatory responses in Balb/c @entity1 after oral gavage of AFG1 for 1, 3 and 6 months. Inflammatory responses were heightened in the lung alveolar septum, 3 and 6 months after AFG1 treatment, evidenced by increased macrophages and lymphocytes infiltration, up-regulation of NF-kB and p- @entity13 , and cytokines production. High expression levels of @entity8 dismutase ( @entity7 ) and hemoxygenase-1 (HO-1), two established markers of oxidative stress, were detected in alveolar epithelium of AFG1-treated @entity1 . Promoted @entity6 in alveolar epithelium and angiogenesis, as well as increased @entity12 expression were also observed in lung tissues of AFG1-treated @entity1 . Furthermore, we prolonged survival of the @entity1 in the above model for another 6 months to examine the contribution of AFG1-induced chronic @entity2 to lung tumorigenesis. Twelve months later, we observed that AFG1 induced @entity11 and @entity9 in Balb/c @entity1 . Up-regulation of NF-kB, p- @entity13 , and @entity12 was also induced in @entity10 , thus establishing a link between AFG1-induced chronic @entity2 and lung tumorigenesis. This is the first study to show that oral administration of AFG1 could induce @entity4 , which may provide a pro- @entity0 microenvironment to contribute to lung tumorigenesis.

title: Oral administration of @entity14 induces XXXX associated with lung tumorigenesis.

answer: @entity2