abstract: BACKGROUND: Crusted scabies is a severe, @entity1 associated with immune suppression. Affected individuals typically present with crusted @entity2 in a variety of locations. This condition can lead to severe complications: institutional outbreaks and secondary @entity12 associated with @entity5 and high mortality. MAIN OBSERVATIONS: A 37-year-old @entity0 with a 12-year history of @entity7 treated with @entity4 , @entity8 , and @entity14 presented with a three-week history of a @entity3 scalp @entity10 with adherent yellow scale. Skin biopsy and tissue culture were consistent with a diagnosis of crusted scabies with superficial @entity12 . The @entity0 was treated with oral @entity13 and @entity6 cream, as well as @entity11 for the @entity12 . At one-week follow-up, the scalp was no longer tender and hyperkeratotic plaques had significantly improved. At one-month follow-up, the affected scalp demonstrated further improvement with decreasing erythema and @entity9 with follicular ostia. CONCLUSIONS: Our case highlights the atypical presentation of crusted scabies with primary scalp involvement and need for vigilance in recognizing and appropriately treating this condition to prevent the consequences of longstanding infection. Combination treatment with @entity13 and @entity6 is appropriate management for this condition.

title: Crusted scabies of the scalp in a XXXX with @entity7 .

answer: @entity0


abstract: @entity0 islet cells in culture are able to form tridimensional aggregates with an architecture and functional activity similar to native islets: pseudoislets. Pseudoislets represent an alternative source for islet transplantation, because their transplant results in a long term allograft acceptance without immunosuppression of the host. Use of pseudoislets has been limited by their reduced yield and by poor reaggregation mass. Since culture conditions have been reported to affect reaggregation, the aim of this study was to evaluate the effects of different concentrations of two sera ( @entity2 [ @entity2 ] and @entity3 [ @entity3 ]) on reaggregation and insulin gene expression in pseudoislets. Islets were isolated from male Lewis @entity0 by means of histopaque gradient centrifugation. The day after islets were disrupted into single cells and cultured in RPMI 1640 5.6 mM @entity1 with 2%, 5% and 10% solutions of both @entity2 and @entity3 . Cells spontaneously reaggregated to form pseudoislets. After seven days of culture, pseudoislets were counted and analysed for insulin secretion and insulin gene expression using RT-PCR. Rat serum increased the number of aggregates and their diameters. Insulin gene expression of pseudoislets cultured with @entity3 showed a ten fold increase in comparison to those cultured with @entity2 . These data show that the culture medium supplemented with @entity3 improves total reaggregate volume and increases insulin gene expression. With the perspective of pseudoislets' use in transplantation @entity3 is better indicated than @entity2 for the production of @entity0 pseudoislets.

title: Rat serum improves XXXX pseudoislet formation and insulin gene expression.

answer: @entity0


abstract: @entity1 has become an uncommon disease in developed countries. @entity1 is caused by exotoxins from the bacteria @entity2 . This microbe, which is obligate anaerobe, is present in soil, and animal and @entity0 faeces. The condition usually appears after contamination of wounds. However, reports have been published of @entity1 occurring after both acute and selective gastrointestinal surgery. We present a case of severe postoperative @entity1 in a 57 year-old @entity0 who underwent bowel resection after strangulation of the ileum. The @entity0 was treated on an intensive care unit and was artificially ventilated for 64 days. Seven months later she had fully recovered. Clinical presentation, diagnosis, treatment, and complications are discussed in the report. The diagnosis of @entity1 is made by clinical observation. Nowadays, lack of suspicion of this condition may cause delay in administering proper treatment. @entity0 and older @entity0 are often inadequately immunized. Doctors should therefore examine the immunization status of these groups of @entity0 regularly.

title: [Postoperative XXXX after gangrenous ileus].

answer: @entity1


abstract: In a randomized study, @entity9 was compared with @entity4 for the treatment of @entity1 in a total of 239 adults from 56 sites in 20 countries. This study provided a unique opportunity to assess the frequency and outcome of @entity1 caused by different Candida species worldwide, and the results are presented here. Efficacy was primarily assessed at the end of intravenous therapy using a modified intent-to-treat (MITT) analysis. This analysis was performed on 224 of the 239 @entity0 enrolled in the study. Attempts were made to collect baseline Candida isolates from all @entity0 for species identification at a central laboratory. @entity3 were identified to the species level using two commercial systems and microscopic examination. Viable baseline isolates were recovered from 210 of the 224 (94%) @entity0 included in the MITT analysis. @entity5 was the most frequently isolated species in all regions and was responsible for 45% of cases overall. Nevertheless, the majority of cases of @entity2 were caused by non- albicans Candida species. In the USA and Canada, @entity6 was the second most commonly isolated pathogen (18%). In contrast, @entity7 and @entity8 accounted for 55% of cases in Latin America. Outcomes were comparable for @entity0 treated with @entity9 (74% overall; 64% and 80% for infections due to @entity5 and non- albicans species) and @entity4 (62% overall; 58% and 68% for infections due to @entity5 and non- albicans species), and were generally similar across continents. The distribution of Candida species isolated from @entity0 enrolled in a clinical trial may not be representative of pathogens causing @entity1 in the general population. Nevertheless, our findings may affect the regional choice of empirical antifungal therapy for seriously ill @entity0 with suspected or documented @entity1 since different Candida species have varying susceptibility to conventional antifungal drugs.

title: Global distribution and outcomes for Candida species causing @entity1 : results from an international randomized double-blind study of XXXX versus @entity4 for the treatment of @entity1 .

answer: @entity9


abstract: UNASSIGNED: OBJECT Previous forceplate studies analyzing the impact of sagittal-plane @entity1 on pelvic parameters have demonstrated the compensatory mechanisms of pelvis translation in addition to rotation. However, the mechanisms recruited for this pelvic rotation were not assessed. This study aims to analyze the relationship between spinopelvic and @entity6 parameters and clarify the role of pelvic translation. METHODS This is a retrospective study of @entity0 with @entity1 images. @entity0 with only @entity3 or @entity5 were excluded. @entity0 were grouped according to T-1 spinopelvic inclination (T1SPi): sagittal forward (forward, > 0.5  ), neutral (-6.3   to 0.5  ), or backward (< -6.3  ). Pelvic translation was quantified by pelvic shift (sagittal offset between the posterosuperior corner of the sacrum and anterior cortex of the distal tibia), hip extension was measured using the sacrofemoral angle (SFA; the angle formed by the middle of the sacral endplate and the bicoxofemoral axis and the line between the bicoxofemoral @entity7 ), and chin-brow vertical angle (CBVA). Univariate and multivariate analyses were used to compare the parameters and correlation with the @entity2 Index (ODI). RESULTS In total, 336 @entity0 (71% female; mean age 57 years; mean body mass index 27 kg/m(2)) had mean T1SPi values of -8.8  , -3.5  , and 5.9   in the backward, neutral, and forward groups, respectively. There were significant differences in the @entity6 and spinopelvic parameters between T1SPi groups. The backward group had a @entity4 (LL), negative SVA and pelvic shift, and the largest hip extension. Forward @entity0 had a small LL and an increased SVA, with a large pelvic shift creating compensatory knee flexion. Significant correlations existed between lower-limb parameter and pelvic shift, pelvic tilt, T-1 pelvic angle, T1SPi, and sagittal vertical axis (0.3 < r < 0.8; p < 0.001). ODI was significantly correlated with knee flexion and pelvic shift. CONCLUSIONS This is the first study to describe full-body alignment in a large population of @entity0 with spinal pathologies. Furthermore, @entity0 categorized based on T1SPi were found to have significant differences in the pelvic shift and lower-limb compensatory mechanisms. Correlations between lower-limb angles, pelvic shift, and ODI were identified. These differences in compensatory mechanisms should be considered when evaluating and planning surgical intervention for adult @entity0 with @entity1 .

title: Role of pelvic translation and @entity6 to maintain gravity line position in XXXX .

answer: @entity1


abstract: Mating activates @entity3 sensitive neurons in several regions of male @entity0 brain, including the @entity6 ( @entity6 ). Infusion of the aromatase inhibitor, @entity5 , into the @entity6 reduced mating, presumably by inhibiting conversion of @entity4 (T) to @entity1 (E(2)). We investigated whether administering E(2) locally into the amygdala (AMG) would maintain @entity2 in male @entity0 given systemic @entity5 to eliminate E(2) elsewhere in the brain. Gonadally intact male @entity0 were divided into two matched groups, based on ejaculatory performance in weekly tests with receptive females. All males received 0.29 mg/kg/day sc @entity5 and bilateral implants to AMG. E(2)-in-AMG males (N=6 experimentals) received implants tipped with a cured mixture of E(2) in Silastic Medical Adhesive, whereas Vehicle-in-AMG males (N=6 controls) received implants tipped with cured adhesive alone (without E(2)). In E(2)-in-AMG males, postoperative mount and intromission frequency did not differ significantly from pretreatment baseline levels, but ejaculation frequency declined significantly (P<.01). Conversely, in Vehicle-in-AMG males, postoperative mounts and intromissions (P<.01) and ejaculations (P<.01) declined significantly. Postoperative mount and intromission frequency of Vehicle-in-AMG males was significantly lower than that of E(2)-in-AMG males (P<.01), but ejaculation frequency did not differ significantly between groups. This suggests that E(2)-sensitive AMG neurons are important for sexual arousal but not ejaculatory performance.

title: @entity1 in the male XXXX amygdala facilitates mounting but not ejaculation.

answer: @entity0


abstract: In male hypogonadic mutant @entity0 (hgn/hgn), gonocytes degenerate and peritubular cells form multiple layers around seminiferous tubules during early postnatal testicular development. Alkaline phosphatase (AP) activity has been used as not only a tracer for the @entity1 ( @entity1 ) but also a histochemical marker for the peritubular myoid cells. In the present study, we examined the localization of AP activity during the postnatal testicular development in the hgn/hgn and phenotypically normal (+/+ or +/hgn) @entity0 . In the normal testis, high AP activity was located in the surface of the @entity1 on 3 days of age. As the @entity1 differentiated into spermatogonia, the AP activity drastically decreased in intensity on 7 days and was completely lost by 12 days. In the hgn/hgn, the @entity1 showing high AP activity occupied the inside of dilated seminiferous tubules on 3 and 7 days of age. The luminal AP activity declined gradually by 18 days and disappeared on 21 days, when the germ cells completely degenerated in the hgn/hgn testis. In the normal, high AP activity emerged in a layer of the peritubular cells surrounding the tubules on 7 days and afterwards, indicating that the peritubular cells were differentiating into myoid cells. In the hgn/hgn, the peritubular cells formed multiple layers around the tubules and showed weak AP activity on 3 to 18 days of age. On 21 days of age, high AP activity emerged in a single layer of the peritubular cells directly attached to the basement membrane in the hgn/hgn. These results indicate that the @entity1 showing AP activity kept remained at later stage in the hgn/ hgn and that the single layer of mature myoid cells showing high AP activity appeared much later in the hgn/hgn testis than in normal.

title: Temporal and spatial distribution of alkaline phosphatase activity in male hypogonadic XXXX (hgn/hgn) testis during postnatal development.

answer: @entity0


abstract: UNASSIGNED: Background Delirium is an acute change in mental status characterized by sudden onset, fluctuating course, inattention, disorganized thinking, and abnormal level of consciousness. The objective of the randomized controlled trial "A STrategy to Reduce the Incidence of @entity2 in Elderly @entity0 " (STRIDE) is to assess the effectiveness of light versus heavy sedation on @entity3 and other outcomes in elderly @entity0 undergoing @entity1 repair surgery. Our goal is to describe the design considerations and lessons learned in planning and implementing the STRIDE trial. Methods Discussed are challenges encountered including (1) how to ensure that we quickly identify, assess the eligibility of, and randomize traumatic @entity1 @entity0 ; (2) how to implement interventions that involve continuous monitoring and adjustment during the surgery; and (3) how to measure and ascertain the primary outcome, @entity3 . Results To address the first challenge, we monitored the operating room schedule more actively than anticipated. We constructed and organized eligibility assessment data collection forms by purpose and by source of information needed to complete them. We decided that randomization needs to take place in the operating room. To address the second challenge, we designed and implemented a treatment protocol and covered the bispectral index monitor to prevent the Anesthesiologist/Anesthetist from being influenced by the bispectral index reading while administering the intervention. Finally, clinical assessment of @entity3 consisted of standardized interviews of the @entity0 using validated instruments, interviews of those caring for the @entity0 , and review of the medical record. A consensus panel made the final determination of a @entity3 diagnosis. We note that STRIDE is a single-center trial. The decisions we took may have different implications for multi-center trials. Conclusions Lessons learned are likely to provide useful information to others designing trials in emergency and surgical setting and for those who are interested in unbiased assessment of @entity3 .

title: Design considerations of a randomized controlled trial of sedation level during XXXX repair surgery: a strategy to reduce the incidence of @entity2 in elderly @entity0 .

answer: @entity1


abstract: UNASSIGNED: @entity3 is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between @entity5 ( @entity5 ) gene polymorphisms and @entity3 risk has attracted widespread attention due to the unique biological functions of FSH. The aim of this study was to further explore the associations between the @entity7 and @entity4 polymorphisms of the @entity5 gene and @entity3 . A case-control study of 212 @entity1 and 164 fertile @entity0 from North China was performed. @entity5 polymorphism genotypes were obtained through direct DNA sequencing. A meta-analysis was also performed. In the single-site association analysis, no significant associations were identified between @entity5 @entity7 and @entity4 polymorphisms and @entity3 (P > 0.05). However, we found that the combined genotypic frequency of Thr/Ala + @entity2 / @entity2 was higher in @entity1 @entity0 than in controls (6.6 vs 1.8%; odds ratio (OR) = 3.795; 95% confidence interval (CI): 1.072-13.434, P = 0.027). In the meta-analysis, there was also no evidence of @entity5 polymorphism ( @entity6 and @entity8 ) association with @entity3 (P > 0.05). However, we found that the combined genotypes Thr/Thr + @entity2 / @entity2 had an increased risk of @entity3 (OR = 1.238; 95%CI: 1.001-1.537, P = 0.049). Our studies further confirmed reports that there were no significant associations between the @entity5 @entity7 and @entity4 polymorphisms and @entity3 risk. However, a combined @entity5 genotype showed significant association with @entity3 .

title: @entity5 gene @entity7 and @entity4 polymorphisms in XXXX @entity0 : an association study in North China and meta-analysis.

answer: @entity1


abstract: We report on a case of a @entity2 of the sporadic type successfully treated by endoscopic electroresection. From January 1998 to October 2002, 1523 gastroscopies were performed in the Palermo University General Emergency Surgery and Organ Transplant Unit. In a 59-year-old @entity0 with a history of @entity4 , a @entity3 was observed in the gastric corpus. Laboratory data were normal. The lesion was successfully treated by electroresection. Histological evaluation revealed an 8-mm-diameter well-differentiated @entity1 infiltrating the muscularis mucosa. According to Rindi et al.'s classification, the polyp was a carcinoid of the sporadic type. A two-year follow-up consisting in gastroscopy every 6 months and evaluation of @entity1 markers and CT scans once a year has so far shown no recurrence. Surgical treatment is the therapy of choice for @entity2 , but endoscopic resection may be a successful alternative in cases of @entity5 measuring less than 1 cm and presenting multricentric growth. Moreover, endoscopy can also be used in patents at high surgical risk.

title: [Endoscopic treatment of XXXX . Report of a clinical case].

answer: @entity2


abstract: We report the successful treatment of a 77-year-old @entity0 after a difficult diagnosis of @entity2 resulting from complete rupture of the anterior papillary muscle. The @entity0 with @entity7 was an emergency admission. An electrocardiogram showed acute lateral wall @entity5 . He had complications of @entity4 and a high-grade fever. Transesophageal echocardiography seemed to show the appearance of a large area of @entity1 attached to the anterior mitral valve leaflet and aortic non-coronary cusp, resulting in severe @entity2 . We performed coronary angiography, which showed @entity3 . We determined that the condition was caused by @entity6 . Emergency surgery showed the complete rupture of the anterior papillary muscle, but there was no @entity1 . The mitral valve was replaced with a bioprosthetic valve and the circumflex coronary artery was bypassed with a saphenous vein graft. Pathological examination revealed mitral valve to be non-mycotic, and the postoperative course was uneventful.

title: Acute XXXX due to complete rupture of anterior papillary muscle mimicking mitral valve vegetation.

answer: @entity2


abstract: OBJECTIVE: To establish the prevalence of @entity2 ( @entity2 ) in @entity0 with @entity5 treated with swallowed @entity4 (FP) or @entity3 . STUDY DESIGN: @entity0 treated with FP or @entity3 for >= 6  months underwent a low-dose adrenocorticotropin stimulation test. @entity0 using systemic, inhaled, intranasal, or topical glucocorticoids were excluded. The primary outcome is @entity2 , defined as peak serum @entity1 <18   g/dL ( <=495  nmol/L). RESULTS: Of 58 @entity0 (81% male), 67% were on FP (median age 13.7  years [range 4.3-19.1], dose 1320   g/d [440-1760], treatment duration 4.0  years [0.6-13.5]). Thirty-three percent were on @entity3 (median age 10.7  years [range 3.2-17.2], dose 1000   g/d [500-2000], treatment duration 3.4  years [0.6-7.7]). The overall prevalence of abnormal peak @entity1 response ( <=20   g/dL) was 15% (95% CI 6%-25%) (indeterminate [18-20   g/dL] 5% [n  =  3] vs @entity2 [<18   g/dL] 10% [n  =  6]). All @entity0 on @entity3 had a normal response vs only 77% of @entity0 on FP (P  =  .02), all of whom were taking FP at a dose >440   g/d. CONCLUSIONS: @entity2 was present in 10% of @entity0 treated with swallowed glucocorticoids for >= 6  months and was found only in those treated with FP >440   g/d. We recommend low-dose adrenocorticotropin stimulation testing in @entity0 treated long term with high dose FP to allow early detection of @entity2 .

title: XXXX after Chronic Swallowed Glucocorticoid Therapy for @entity5 .

answer: @entity2


abstract: BACKGROUND: Conventional pacemaker implantation induces @entity2 , which might affect the LV function. We sought to evaluate the impact of different right ventricular (RV) pacing sites on the @entity2 and performance. METHODS: Comprehensive echocardiographic evaluation including the @entity1 based on M-mode, conventional Doppler and tissue Doppler imaging (TDI) was done before and immediately after (< 7 days) pacemaker implantation. For the LV performance, LV ejection fraction, longitudinal peak systolic velocity at the mitral annulus (S') annular or mean longitudinal velocity of the 6 basal segments (Sm) were used. These results were compared with those of 15 age matched controls. RESULTS: A total of 79 @entity0 (48 females, mean age 63    12 years) underwent RV pacing at the apex (n = 45, group I) or the septum (n = 34, group II). After pacemaker implantation, the QRS duration was significantly increased in both groups, but the change was greater in group I (57.1    28.3 versus 32.8    40.5 msec). Both the S' and Sm were lower in pacing groups than those in controls and Sm was significantly higher in group II (4.2    1.0 versus 4.9    1.3 m/sec) than group I despite a similar LV ejection fraction. The aortic pre-ejection time and septal to posterior wall motion delay in @entity0 with pacemaker were longer compared to normal controls, but there were no significant differences. Both the TDI velocity and strain analysis showed no difference of the dyssynchrony indices between the two groups, despite a higher tendency of @entity3 indices in the RV apical pacing group compared to those of the control. CONCLUSION: Despite the marked increase of the QRS duration after pacing, M-mode, Doppler and @entity4 failed to demonstrate any difference according to the pacing sites. The long-term effect of the longitudinal contraction being less affected and a smaller increase of the QRS duration in the RV septal pacing group needs to be confirmed in a longitudinal follow-up study.

title: Comparison of XXXX according to the position of right ventricular pacing electrode: a multi-center prospective echocardiographic study.

answer: @entity1


abstract: Summary. With increasing use of motorcycle as means of transport in developing countries, @entity2 from motorcycle crashes have been increasing. The only single gadget that protects riders from @entity2 is crash helmet. Objective. The objectives were to determine the treatment outcome among @entity2 @entity0 from motorcycle crashes and the rate of helmet use among them. Methods. It was a prospective, cross-sectional study of motorcycle-related @entity2 @entity0 managed in our center from 2010 to 2014. @entity0 were managed using our unit protocol for @entity2 . Data for the study were collected in accident and @entity3 , intensive care unit, wards, and outpatient clinic. The data were analyzed using Environmental Performance Index (EPI) info 7 software. Results. Ninety-six @entity0 were studied. There were 87 males. Drivers were 65. Only one @entity0 wore helmet. Majority of them were between 20 and 40 years. Fifty-three @entity0 had mild @entity4 . Favorable outcome among them was 84.35% while mortality was 12.5%. Severity of the injury affected the outcome significantly. Conclusion. Our study showed that the helmet use by motorcycle riders was close to zero despite the existing laws making its use compulsory in Nigeria. The outcome was related to severity of @entity1 .

title: Motorcycle-Related XXXX : Helmet Use and Treatment Outcome.

answer: @entity2


abstract: PURPOSE: To determine the safety and effectiveness of Guglielmi detachable coils in the endovascular treatment of ruptured and nonruptured basilar tip @entity3 . MATERIALS AND METHODS: A basilar @entity3 was occluded with Guglielmi detachable coils in 21 @entity0 . The aneurysmal diameter was small (less than 12 mm) in 15 @entity0 , large (12-25 mm) in four @entity0 , and giant (more than 25 mm) in two @entity0 . Angiographic follow-up ranged from 6 to 48 months (mean, 26 months); clinical follow-up ranged from 1 to 48 months. RESULTS: Embolization was technically successful in all @entity0 . Complete occlusion was achieved in 14 (67%) @entity0 ; 90% occlusion was achieved in seven (33%) @entity0 . There was partial reperfusion of the @entity3 in three @entity0 (14%) after 6 months, which necessitated repeated embolization. The clinical results were excellent in 13 @entity0 , good in six, and fair in one. One @entity0 died 2 months after the embolization due to @entity2 . A posterior cerebral artery was occluded in five (24%) @entity0 ; one of these @entity0 developed a permanent @entity1 , one developed a transient @entity1 , and three had no clinical symptoms. CONCLUSION: Endovascular treatment of a basilar @entity3 with Guglielmi detachable coils seems to be a safe and less invasive alternative to surgical clipping.

title: Basilar XXXX : endovascular treatment with Guglielmi detachable coils--midterm results.

answer: @entity3


abstract: BACKGROUND: The growing number of @entity0 with @entity1 has increased both the pressure on hospital resources and the need for community management of the condition. Improving hospital-to-home transition for this population is a logical step in responding to current practice guidelines' recommendations for coordination and education. Positive outcomes have been reported from trials evaluating multiple interventions, enhanced hospital discharge, and follow-up through the addition of a case management role. The question remains if similar gains could be achieved working with usual hospital and community nurses. METHODS: A 12-week, prospective, randomized controlled trial was conducted of the effect of transitional care on health-related quality of life (disease-specific and generic measures), rates of readmission, and emergency room use. The nurse-led intervention focused on the transition from hospital-to-home and supportive care for self-management 2 weeks after hospital discharge. RESULTS: At 6 weeks after hospital discharge, the overall Minnesota Living with @entity1 Questionnaire (MLHFQ) score was better among the Transitional Care @entity0 (27.2 +/- 19.1 SD) than among the Usual Care @entity0 (37.5 +/- 20.3 SD; P = 0.002). Similar results were found at 12 weeks postdischarge for the overall MLHFQ and at 6- and 12-weeks postdischarge for the MLHFQ's Physical Dimension and Emotional Dimension subscales. Differences in generic quality life, as assessed by the SF-36 Physical component, Mental Component, and General Health subscales, were not significantly different between the Transition and Usual Care groups. At 12 weeks postdischarge, 31% of the Usual Care @entity0 had been readmitted compared with 23% of the Transitional Care @entity0 (P = 0.26), and 46% of the Usual Care group visited the emergency department compared with 29% in the Transitional Care group (chi2 = 4.86, df 1, P = 0.03). CONCLUSIONS: There were significant improvements in health-related quality of life (HRQL) associated with Transitional Care and less use of emergency rooms.

title: Quality of life of individuals with XXXX : a randomized trial of the effectiveness of two models of hospital-to-home transition.

answer: @entity1


abstract: UNASSIGNED: It is widely accepted that substantial nighttime sap flux (J s,n) or transpiration (E) occurs in most plants, but the physiological implications are poorly known. It has been hypothesized that J s,n or E serves to enhance @entity2 uptake or deliver @entity0 ; however, no clear evidence is currently available. In this study, sap flux (J s) in @entity6 * urophylla with apparent stem photosynthesis was measured, including control trees which were covered by @entity3 foil (approximately 1/3 of tree height) to block stem photosynthesis. We hypothesized that the nighttime water flux would be suppressed in trees with lower stem photosynthesis. The results showed that the green tissue degraded after 3  months, demonstrating a decrease in stem photosynthesis. The daytime J s decreased by 21.47  %, while J s,n decreased by 12.03  % in covered trees as compared to that of control, and the difference was statistically significant (P   <   0.01). The linear quantile regression model showed that J s,n decreased for a given daytime transpiration water loss, indicating that J s,n was suppressed by lower stem photosynthesis in covered trees. Predawn (   pd) of covered trees was marginally higher than that of control while lower at predawn stomatal conductance (g s), indicating a suppressed water flux in covered trees. There was no difference in leaf @entity1 content and   @entity4 between the two groups, while leaf @entity2 content and   @entity5 were significantly higher in covered trees than that of the control (P   <   0.05), indicating that J s,n was not used for @entity2 uptake. These results suggest that J s,n may act as an @entity0 pathway since green tissue has a higher respiration or @entity0 demand than non-green tissue. Thus, this study demonstrated the physiological implications of J s,n and the possible benefits of nighttime water use or E by the tree.

title: Suppression of nighttime sap flux with lower stem photosynthesis in XXXX trees.

answer: @entity6


abstract: UNASSIGNED: The gold standard for identifying @entity1 lesions is manual tracing, a method that is known to be observer dependent and time consuming, thus impractical for big data studies. We propose LINDA (Lesion Identification with Neighborhood Data Analysis), an automated segmentation algorithm capable of learning the relationship between existing manual segmentations and a single T1-weighted MRI. A dataset of 60 left hemispheric @entity1 @entity0 is used to build the method and test it with k-fold and leave-one-out procedures. With respect to manual tracings, predicted lesion maps showed a mean dice overlap of 0.696        0.16, Hausdorff distance of 17.9        9.8 mm, and average displacement of 2.54        1.38 mm. The manual and predicted lesion volumes correlated at r   =   0.961. An additional dataset of 45 @entity0 was utilized to test LINDA with independent data, achieving high accuracy rates and confirming its cross-institutional applicability. To investigate the cost of moving from manual tracings to automated segmentation, we performed comparative lesion-to-symptom mapping (LSM) on five behavioral scores. Predicted and manual lesions produced similar neuro-cognitive maps, albeit with some discussed discrepancies. Of note, region-wise LSM was more robust to the prediction error than voxel-wise LSM. Our results show that, while several limitations exist, our current results compete with or exceed the state-of-the-art, producing consistent predictions, very low failure rates, and transferable knowledge between labs. This work also establishes a new viewpoint on evaluating automated methods not only with segmentation accuracy but also with brain-behavior relationships. LINDA is made available online with trained models from over 100 @entity0 . Hum Brain Mapp, 2016.    2016 Wiley Periodicals, Inc.

title: Automated segmentation of XXXX using LINDA: Lesion identification with neighborhood data analysis.

answer: @entity1


abstract: UNASSIGNED: Objective. The aim of this pilot study was to compare the occurrence of @entity3 ( @entity3 ) symptoms, @entity2 ( @entity2 )-related symptoms, and negative mood regulation capacities among Israeli Jewish and Arab @entity0 and their parents, all of whom had been exposed to recurrent missiles attacks during the Second Lebanon War. Methods. @entity0 consisted of 28 Jewish and 14 Arab @entity0 (aged 4-18 years) and their parents. They were assessed by self-report instruments and a semi-structured interview (K-SADS-PL). Results. Among @entity0 , @entity3 and @entity2 were found to be interrelated. Parents' @entity2 and mood regulation were found to be related to their @entity0 's @entity3 and @entity2 responses. Both @entity0 's and parents' negative mood regulation capacities were inversely related to @entity0 's @entity2 and @entity3 symptoms. Both Jewish and Arab @entity0 's scores on the @entity0 Depression Inventory (CDI) and on the @entity3 Scale Symptoms Interview (PSS-I) showed significant levels of @entity1 following the missile attacks. However, Arab @entity0 reported significantly higher levels of @entity3 and @entity2 in comparison to Jewish @entity0 . Conclusion. Ethnicity seems to be an important factor in @entity0 's responses to war-related events.

title: Effects of ethnicity on sub-clinical XXXX and @entity2 , following exposure to missile attacks in Israel-A pilot study.

answer: @entity3


abstract: AIMS AND OBJECTIVES: To understand the experiences of @entity0 with a history of @entity1 when they attempted to gain parenting support. BACKGROUND: Becoming a mother provides a window of opportunity to support @entity0 with a @entity1 make changes to their lives and the way they will parent their @entity0 and young @entity0 . Yet there are many barriers and a constant fear of the removal of their @entity0 from their care. DESIGN: Focus groups were conducted using a qualitative interpretive descriptive approach to enable exploration of the @entity0 's experiences as mothers with @entity0 and young @entity0 . METHOD: A series of three focus groups were facilitated with three to six @entity0 per group. Thirteen @entity0 who were substance dependent participated in this study. Semi-structured interviews guided the collection of data. Thematic content analysis was used to work with the data. RESULTS: Four themes were identified: (1) feelings of guilt, (2) judged by others, (3) normalising and (4) support and learning to be a mother. CONCLUSION: The mothers expressed alienation from mainstream health services. Providing parenting and @entity0 health services, which avoid mothers feeling judged by the staff and other mothers, is an important step to enabling these @entity0 to appropriately and sensitively care for their @entity0 and young @entity0 . RELEVANCE TO CLINICAL PRACTICE: Midwives and nurses working with mothers and their @entity0 and young @entity0 are well positioned to support @entity0 who are or have experienced @entity1 . Working with this group of mothers requires the development of a therapeutic relationship to provide optimum support, education and, if necessary, intervention.

title: Experiences of mothers with XXXX : Informing the development of parenting support.

answer: @entity1


abstract: INTRODUCTION: Workers' compensation @entity0 are known to be associated with inferior outcomes following lumbar surgery. We investigated demographics and clinical characteristics between the reoperative and non-reoperative group of @entity0 undergoing decompression-alone lumbar surgery (discectomy and/or laminectomy) for on-the-job injuries (OJI) at our institute, and evaluated its possible impact on the @entity1 ( @entity1 ). METHODS: A retrospective analysis of @entity0 undergoing lumbar surgery for OJI between 2003 through 2010 by a single surgeon (A.N.) was performed. A comparison of baseline clinical and demographic parameters between the two groups was compared using Fisher's exact test for the categorical variables and the independent t-test (2-tailed) for the continuous variables. Overall, @entity1 was presented in Kaplan-Meier curves and the @entity1 difference was compared using log-rank (Mantel-Cox) test. Cox proportional hazard model was used for the univariate and multivariate analysis and hazard ratios with 95% confidence intervals were reported. RESULTS: About 92 @entity0 with mean age 48.07  10.10 years and mean follow-up of 36.4 (range 24.3-66.0) months were included. About 38 (41.3%) @entity0 underwent reoperation for failed decompression-alone procedures whereas the non-reoperative cohort comprises 54 (58.7%) @entity0 . Female gender (p=0.015) and history of previous surgery (p=0.05) were associated with a higher chance of reoperation. Majority of the reoperations (20/38, 52.6%) were performed within the first 2 years, with a @entity1 at the end of 2 years being 78.3% (n=72) and 58.9% (n=53) at 5 years. Cox-regression analysis did not demonstrate any influence of @entity0 and treatment-related factors on the @entity1 . CONCLUSION: There is a substantial risk of redo surgeries following decompression-alone lumbar procedures for OJI. As @entity0 and treatment-related factors did not influence the reoperation rates and @entity1 in this study, it appears that workman compensation status of @entity0 is inherently associated with poor outcomes following spine surgeries.

title: Predictors of XXXX following decompression-alone lumbar spine surgery for on-the-job injuries.

answer: @entity1


abstract: OBJECTIVE: Surgical resection of sacral @entity5 offers the best long-term prognosis but has high rates of local recurrence, @entity1 , and mortality. Most prognostic studies are limited by low @entity0 numbers, variation in treatment, follow-up, and prognostic variables studied. The objective of this study was to identify factors associated with recurrence, @entity1 , and survival. METHODS: Retrospective review of 58 @entity0 undergoing sacrectomy for @entity5 with a mean age of 63 years (range: 41-80 years) and a mean follow-up of 45.3 months (range: 2-144 months). Data on prognostic variables and outcomes were collected. Forty-two @entity0 underwent a combined anterior and posterior approach and 16 underwent a posterior-only approach. RESULTS: Twenty-six @entity0 (44.8%) died during follow-up. Kaplan-Meier estimates for 5- and 10-year survival were 62% and 26%, respectively. Local recurrence occurred in 32 @entity0 (51.7%) and @entity1 in 19 (32.7%). Adequacy of resection margins was the most important predictor of disease recurrence, @entity1 , and survival. Tumors >8 cm were associated with significantly increased risk of @entity1 and reduced survival (P < 0.05). @entity3 and infiltration of the @entity4 and/or adjacent musculature were also associated with reduced survival. Median survival was 23 months for @entity0 with @entity1 , 66 months for gluteus maximus and @entity1 , 67 months for @entity1 , and 90 months for @entity0 with no muscle invasion. CONCLUSIONS: @entity0 with inadequate resection margins, @entity2 >8 cm, sacroiliac joint and/or musculature infiltration, and dedifferentiated disease have significantly worse oncologic outcomes. Involvement of gluteus maximus alone confers a higher risk of @entity1 and local recurrence than involvement of piriformis and gluteus maximus, or piriformis alone.

title: Prognostic Factors in the Operative Management of Sacral XXXX .

answer: @entity5


abstract: The aim of this study was to evaluate the efficiency and safety of single-agent bevacizumab therapy for recurrent @entity4 ( @entity4 ). We identified @entity0 with histologically confirmed @entity4 and World Health Organization Grade III @entity1 who were previously treated with @entity5 plus radiotherapy and received 10  mg/kg bevacizumab intravenous infusion every 2  weeks until disease progression for recurrent disease. A total 24 @entity0 included to this study. Twenty-two @entity0 had @entity4 , and two @entity0 had WHO grade III @entity1 . No complete response was observed, five @entity0 (20.8  %) had partial response, nine @entity0 (37.5  %) had stable diseases, and ten @entity0 (41.7  %) had progressive diseases. The overall response rate was 20.8  %. The 6-month PFS rate (PFS6) and median PFS were determined as 37.5  % and 4.1  months, respectively. Median @entity6 was 6.4  months. Performance status of 17 (70.8  %) @entity0 was improved following bevacizumab regimen. Univariate analysis showed that improvement @entity3 ( @entity3 ) following bevacizumab therapy was a significant predictor of both PFS (p  <  0.001) and @entity6 (p  <  0.020). Bevacizumab-related adverse effects were observed in 13 (54.1  %) @entity0 . Grade 3-4 @entity2 was observed in 4 (16.6  %) @entity0 . Therapy interruptions were experienced in two @entity0 due to adverse effects. Single-agent bevacizumab is an effective and safe treatment alternative in recurrent @entity4 . @entity3 following bevacizumab therapy was a significant predictor of both PFS and @entity6 .

title: Single-agent bevacizumab is an effective treatment in recurrent XXXX .

answer: @entity4


abstract: UNASSIGNED: 5090 Background: Phase I trials have established the combination of pegylated liposomal @entity6 ( @entity13 [D]) and @entity4 as a tolerable regimen for @entity0 (pts) with recurrent @entity1 . Response rates and durations to single agent therapies in recurrent @entity2 are disappointingly low enough to warrant investigation of combination therapies. METHODS: Twenty-five pts with recurrent @entity2 were enrolled in a phase II trial of D 25mg/m2 day 1 with @entity4 650mg/m2 day 1 and 8. All pts were previously treated with @entity11 and @entity9 , and 11 pts had received a second @entity8 regimen for @entity3 . Four pts were @entity8 refractory, four were @entity8 resistant, and 17(68%) were @entity8 sensitive with a mean of 14.5 (range 7 to 29) months since the last @entity8 therapy. The median number of prior chemotherapy regimens was 2 (range 1 to 4). All pts had measurable disease and radiographic responses were determined with CAT scans every three cycles. RESULTS: Twenty-four pts completed 3 to 12 (mean 6) cycles of therapy, and one pt was lost to followup after cycle four. Objective responses were demonstrated in 16 (64%) pts. Seven pts achieved a complete response (CR) with a mean progression free interval (PFI) of 7 (range 6 to 18) months. Nine (36%) pts had a partial response (PR) and six (24%) pts demonstrated @entity3 ( @entity3 ). The PFI for both PR and @entity3 pts was 5.4 (range 3 to 10) months. Three (12%) pts showed progression at cycle 3. Overall 22/25 (88%) pts demonstrated a clinical benefit with disease response or stabilization (17/17 @entity8 sensitive vs. 5/8 @entity8 resistant/refractory). Two pts with PR withdrew secondary to @entity5 at 4 and 5 cycles (recurrent @entity14 ) @entity7 , @entity12 ). There were no episodes of @entity10 . Transient @entity14 @entity10 was observed in 6 (24%) pts and @entity14 @entity7 in one. CONCLUSIONS: The combination of D and @entity4 is an active regimen for recurrent @entity2 , with response rates that exceed those reported for either single agent. No significant financial relationships to disclose.

title: @entity13 and XXXX combination therapy for recurrent @entity2 : Results of a phase II trial.

answer: @entity4


abstract: OBJECTIVE: @entity2 is one of the most serious @entity1 . However, clinical outcomes are generally unsatisfactory. It has been reported that cortical plasticity could influence the restoration of motor function. However, the neurological mechanism of BPI remains unclear, which provides a basis for further investigation. Supplementary motor area ( @entity3 ) plays an important role in the regulation of motor function. This study aims to explore @entity3 -whole brain functional connectivity after deafferentation of the brachial plexus. METHODS: Sixteen BPI @entity0 and eight healthy volunteers were recruited. The seed region was defined by a block-design fMRI program which used unilateral imaginary hand grasp motion as a task stimulus. Next, the ROI-wise functional connectivity between the predefined region and the other regions of the brain was calculated. RESULTS: We discovered decreased ROI-wise functional connectivity between @entity3 and multiple brain regions including precuneus, posterior cingulum cortex and anterior cingulum cortex. CONCLUSIONS: BPI @entity0 showed weakened functional connectivity between hand-grasp related areas and @entity3 as well as multiple regions associated with motor processing or information integration A clear image of the functional status of the brain after deafferentation was provided. On the basis of this discovery, a relationship between changes in neural imaging measurements and clinical outcomes can be expected in future studies.

title: Supplementary Motor Cortical Changes Explored by Resting-state Functional Connectivity in XXXX .

answer: @entity2


abstract: OBJECTIVES: The purpose of this systematic review is to analyze the available literature on structural and functional @entity2 in @entity4 ( @entity4 ) using several brain magnetic resonance imaging (MRI) techniques. METHODS: PubMed and Web of Science were systematically screened for relevant literature using different combinations of keywords regarding structural and functional brain imaging techniques in @entity0 with @entity4 . Reference lists of included articles were hand-searched for additional literature. Eligible articles were assessed on risk of bias and reviewed by two independent researchers. RESULTS: The search query returned 27 articles meeting the inclusion criteria. Methodological quality varied from poor to good. A total of 10 studies evaluated structural gray matter changes. There is conflicting evidence in global gray matter changes, with both increases and decreases shown in different studies. Gray matter changes were demonstrated in specific brain regions. Structural white matter changes were reported in five studies. There is conflicting evidence in total white matter volume due to both @entity1 . Several regional differences were identified in which white matter changes were shown. Functional organization during rest was evaluated in 10 studies. @entity4 @entity0 showed increased activation in specific regions, together with a @entity5 . A total of six studies evaluated brain activity in response to a nociceptive stimulus. Findings suggest that @entity0 demonstrated increased activity in @entity3 -related regions, and decreased activity in analgesic regions. CONCLUSIONS: Overall, there is moderate evidence for regional changes in gray and white matter, together with an altered functional connectivity during rest and increased activity in @entity3 following painful stimulation, evidencing an @entity3 matrix. More longitudinal research is needed to clarify the temporal relationship regarding @entity3 and neuroplastic changes, and integration of different brain imaging techniques is warranted.

title: @entity2 in XXXX : A systematic review(   ).

answer: @entity4


abstract: PURPOSE: To characterize intravoxel incoherent motion (IVIM) parameters in different regions of interest (ROIs) of @entity1 VX2 @entity2 during a follow-up of 4 weeks. MATERIALS AND METHODS: This study was approved by the Institutional Animal Care and Use Committee. In 18 VX2 @entity2 -bearing @entity1 , IVIM DW imaging was serially performed at the 2nd, 3rd, and 4th week separately after @entity0 implantation at 1.5T by using 12 b values. Three ROIs were drawn on the apparent diffusion coefficient (ADC) maps, including the whole lesion, the visibly most restricted diffusion area (MRDA), and peripheral area of @entity0 . For each ROI of @entity0 , serial changes in ADC and D, D*, and f at three timepoints were calculated. The differences of IVIM parameters in different @entity0 at each timepoint were compared. RESULTS: Serial measurements of f in all three ROIs (P   =   0.000, P   =   0.002, and P   =   0.000), ADC for the whole lesion, MRDA (P   =   0.000 and P   =   0.024), and D for MRDA (P   =   0.001) from the 2nd to 4th week illustrated a statistical difference. The overall comparison of ADC (P   =   0.000, P   =   0.014, and P   =   0.000), D (P   =   0.000, P   =   0.001, and P   =   0.000), and f (P   =   0.001, P   =   0.001, and P   =   0.000) for three @entity0 regions at weeks 2, 3, and 4 showed significant differences. D* in all three ROIs at each timepoint showed no significant differences (P   =   0.612, P   =   0.723, and P   =   0.699; 95% confidence interval: 0.184-0.950). CONCLUSION: The peripheral area of @entity0 could be used as an alternative to the whole lesion as ROIs to assess the VX2 @entity2 with IVIM DW imaging, and in the period between weeks 2 and 3. J. Magn. Reson. Imaging 2015.

title: Intravoxel incoherent motion diffusion-weighted MRI for characterizing regional variability and monitoring serial changes of parameters in @entity1 VX2 XXXX .

answer: @entity2


abstract: @entity1 and @entity4 have been associated with extremely high @entity5 rates following successful angioplasty, resulting in increased morbidity and mortality. @entity9 end products (AGEs) accumulate in vascular tissues with aging and at an accelerated rate in @entity1 and @entity4 . AGEs are particularly abundant at sites of @entity6 . AGEs interact with specific receptors ( @entity11 ) present on all cells relevant to the @entity5 process including inflammatory cells and smooth muscle cells. AGEs- @entity11 interaction in vessel wall may lead to @entity3 , smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal @entity8 and @entity5 . Following @entity7 , the interaction of AGEs with monocytes expressing @entity11 can promote migration of inflammatory cells into the lesion and subsequent release of growth factors and cytokines. Binding of AGEs- @entity11 on smooth muscle cells increases chemotactic migration and cellular proliferation. AGEs trigger the generation of reactive @entity2 species, and upregulate the multifunctional transcription factor @entity10 . Finally, AGEs can augment extracellular matrix production by upregulating transforming growth factor-beta. Thus, accumulation of AGEs in vessel wall provides a common mechanism for the high @entity5 rates of @entity0 with @entity1 and @entity4 .

title: Potential role of advanced glycosylation end products in promoting @entity5 in @entity1 and XXXX .

answer: @entity4


abstract: AIM: The purpose was to evaluate the diagnosis and efficacy of management of @entity2 ( @entity2 ) in a tertiary health center of a developing country. METHODS: Forty-six @entity0 aged from 1 day to 7 years were studied. Parameters studied were age, sex, clinical features, and management. RESULTS: Fifty-six percent of @entity0 presented in the neonatal period; however, none of them presented on the first day of life. The majority (91.3%) of @entity0 had left-sided @entity2 . Respiratory distress was the most common clinical feature observed (91.3%). Chest X-ray confirmed the diagnosis in 82.6% of @entity0 , and contrast study was needed in the remaining 17.4%. The survival rate was 87%. It was better in @entity0 presenting late than those presenting in the early neonatal period. Stabilization in the preoperative period improved survival. Not using a chest tube had no adverse effect on survival. CONCLUSION: The relatively increased survival rate of @entity2 in a tertiary health center of a developing country is attributed to delayed arrival to the center. @entity1 compound the survival. More studies are needed before it can be safely said that not using a chest tube has no adverse outcome. Late presentation has been associated with varied manifestations, hence proper clinical evaluation, a high index of suspicion and adequate management, which includes imaging and surgery after stabilization, gives excellent results.

title: Evaluation of XXXX in a tertiary health center of a developing country: management and survival.

answer: @entity2


abstract: PURPOSE: Tumoural @entity3 ( @entity3 ) is a major prognostic @entity2 ( @entity2 ). The efficacy of @entity5 , the only treatment approved at an advanced stage, is limited. Based on previous data, selective internal radiation therapy (SIRT), or (90)Y radioembolization, seems an interesting option. We aimed to compare both treatments in this population. METHODS: We retrospectively compared @entity0 treated in two centres for @entity2 with @entity1 @entity3 . We compared @entity4 ( @entity4 ) between @entity0 treated with SIRT and @entity0 treated with @entity5 . Analyses were performed before and after 1:1 matching with a propensity score for controlling indication bias, using a Cox proportional hazards model. RESULTS: A total of 151 @entity0 were analysed, 34 @entity0 treated with SIRT and 117 @entity0 treated with @entity5 only. In the whole population, SIRT was associated with a higher median @entity4 as compared with @entity5 : 18.8 vs 6.5  months (log-rank p   <   0.001). There was an imbalance of baseline characteristics between @entity0 treated by SIRT and @entity5 , which justified @entity0 matching with use of a propensity score: 24 @entity0 treated with SIRT could be matched with 24 @entity0 treated with @entity5 . @entity4 was estimated with a median of 26.2 vs 8.7  months in @entity0 treated with SIRT vs @entity5 , respectively (log-rank p   =   0.054). Before and after @entity0 matching, the adjusted hazard ratio related to treatment by SIRT was estimated at 0.62 [95  % confidence interval (CI) 0.39-0.97] (p   =   0.037) and 0.40 (95  % CI 0.19-0.82) (p   =   0.013), respectively. CONCLUSION: SIRT seems more effective than @entity5 in @entity0 presenting with @entity2 and @entity1 @entity3 . This hypothesis is being tested in prospective randomized trials.

title: Selective internal radiation therapy compared with @entity5 for XXXX with @entity3 .

answer: @entity2


abstract: Antipsychotic agents, such as @entity3 and @entity4 , have been reported to be beneficial in the treatment of some @entity1 @entity0 . Many @entity1 @entity0 experience 'breakthrough episodes' of @entity7 , with @entity1 or @entity2 recurring despite adequate ongoing levels of one or more mood-stabilizing medications. There are no controlled studies of breakthrough episodes, and there is little open experience to guide clinicians in pharmacotherapy of breakthrough episodes. This report describes the outcome of adjunctive @entity4 treatment in breakthrough episodes of @entity1 . We assessed the outcome of openly adding @entity4 to the medication regimen of 12 outpatients with @entity1 , type I, who suffered breakthrough episodes despite adequate maintenance medication ( @entity5 , @entity6 , or @entity8 , or a combination of these). Prospective ratings were made at each clinical visit using the Clinical Global Impressions and Global Assessment of Functioning scales. @entity0 received @entity4 for a mean of 6.0 months (23.96 weeks, range 0.5-72 weeks) at a mean dose of 2.75 mg/day (range 1-4.5 mg/day). Four @entity0 discontinued medication (two because of lack of efficacy at weeks 6 and 64, and two because of adverse events at weeks 0.5 and 23). Among the remaining eight @entity0 , four experienced a 10-25 point improvement in Global Assessment of Functioning scores and were rated much better on the Clinical Global Impression-Improvement scale. Although one @entity0 suffered a major @entity2 (at week 22), no @entity0 experienced worsening of @entity1 . This small open series suggests a subgroup of @entity1 @entity0 with breakthrough episodes may benefit from treatment with @entity4 .

title: Long-term @entity4 treatment in XXXX : 6-month follow up.

answer: @entity1


abstract: Dendritic cells (DC) are known to be the most potent @entity5 and to stimulate antigen-specific T cell responses. Recently it was reported that @entity1 DC were also capable of modulating the innate immunity by stimulating NK cells through cell-to-cell contact. In the present study, we examined whether @entity0 DC could affect NK activity. Both monocyte-derived and @entity8 (+) blood DC were tested. The addition of DC to cultures of @entity6 (+) cells resulted in the significant dose-dependent enhancement of the killing activity against various NK-sensitive targets. The resultant activity was comparable to that induced by optimal concentrations of various cytokines, including @entity4 , IL-12, @entity7 and @entity3 . Interestingly, DC enhanced the @entity2 of CD3(-) @entity6 (+) NK cells, but not that of CD3(+) @entity6 (+) T cells. Experiments using transwells clearly demonstrated that the enhancement of NK activity by DC was mediated by soluble factors produced by DC. The culture supernatants of DC also stimulated NK activity. The treatment of both DC and their supernatants with anti-human IL-12 or @entity9 antibodies did not block the enhancement of NK cell-mediated cytolysis by DC, indicating that other factor(s) produced by DC were responsible for the enhancement of NK activity. These results suggest that @entity0 myeloid DC can modulate innate immunity by enhancing NK activity.

title: @entity0 monocyte-derived and @entity8 (+) blood dendritic cells enhance NK cell-mediated XXXX .

answer: @entity2


abstract: OBJECTIVE: The objective of this study was to assess the level of agreement between @entity2 subtype classifications made using the Trial of @entity5 Acute @entity2 Treatment (TOAST) and Causative Classification of @entity2 (CCS) systems. METHODS: Study subjects included 13,596 adult @entity0 and @entity0 accrued from 20 US and European genetic research centers participating in the National Institute of @entity1 and @entity2 (NINDS) @entity2 Genetics Network (SiGN). All cases had independently classified TOAST and CCS @entity2 subtypes. Kappa statistics were calculated for the 5 major @entity3 subtypes common to both systems. RESULTS: The overall agreement between TOAST and CCS was moderate (agreement rate, 70%; k = 0.59, 95% confidence interval [CI] 0.58-0.60). Agreement varied widely across study sites, ranging from 28% to 90%. Agreement on specific subtypes was highest for large-artery @entity4 (k = 0.71, 95% CI 0.69-0.73) and lowest for small-artery occlusion (k = 0.56, 95% CI 0.54-0.58). CONCLUSION: Agreement between TOAST and CCS diagnoses was moderate. Caution is warranted when comparing or combining results based on the 2 systems. Replication of study results, for example, genome-wide association studies, should utilize phenotypes determined by the same classification system, ideally applied in the same manner.

title: Agreement between TOAST and CCS XXXX classification: The NINDS SiGN Study.

answer: @entity3


abstract: BACKGROUND: Current guidelines indicate that D2 resection is the standard of care for @entity0 with locally advanced @entity1 . To assess the impact of quality assurance of lymph node removal, non-compliance and contamination in the @entity2 study arms of the Dutch @entity1 Trial were investigated with respect to recurrence and survival. METHODS: The location and numbers of lymph nodes detected at pathological investigation in the Dutch @entity1 Trial were compared according to the guidelines of the Japanese Research Society for the study of @entity1 . Non-compliance was defined as inadequate removal of lymph node stations. Contamination was defined as lymph nodes removed outside the intended level of resection. The dissection groups @entity2 were divided into non-compliance, compliance and contamination categories. Long-term overall survival was calculated for minor (2 or fewer lymph nodes) and major (more than 2 lymph nodes) non-compliance and contamination in the @entity2 group, using Kaplan-Meier plots. RESULTS: Some 1078 @entity0 were included, of whom 711 with potentially curative surgical resections were evaluated. Overall non-compliance was 80  5 per cent in the D1 and 81  6 per cent in the D2 group. Major non-compliance occurred in 15  3 per cent of the D1 and 26  0 per cent of the D2 group. Major contamination hardly occurred. Overall 15-year survival rates in the randomized groups were 21  2 per cent (D1) and 29  0 per cent (D2) (P   =   0  351). After exclusion of @entity0 with major non-compliance and/or major contamination, survival rates were 23  2 per cent (319 @entity0 ) and 32  6 per cent (245) respectively (P   =   0  261). Where there was major non-compliance, survival rates in the D1 (58 @entity0 ) and D2 (86) groups were 10 and 17 per cent respectively (P   =   0  302). Survival in the D2 compliant   +   contaminated group (139 @entity0 ) was significantly better than that in the D1 group without contamination (282): 35  7 versus 19  9 per cent (P   =   0  041). In the D2 group, there was a significant difference in survival between contaminated (95 @entity0 ) and non-contaminated (236) groups: 39 versus 25  1 per cent (P   =   0  041). CONCLUSION: Non-compliance in the D2 dissection group may have obscured a significant difference in survival between the randomized groups. A D2 dissection with contamination was associated with the best survival, suggesting that extended D2 lymph node dissections improve survival.

title: Quality control of lymph node dissection in the Dutch XXXX Trial.

answer: @entity1


abstract: BACKGROUND: The United States (US) has re-instituted @entity4 vaccinations to prepare for an intentional release of the @entity4 into the civilian population. In an outbreak, @entity0 of all ages will be vaccinated. To prepare for the impact of large-scale ring and mass vaccinations, we conducted a systematic review of the complication and mortality risks of @entity4 vaccination. We summarized these risks for post-vaccinial @entity1 , @entity5 ( @entity5 ), @entity6 , @entity5 , and accidental @entity3 (inadvertant autoinoculation). METHODS: Using a MEDLINE search strategy, we identified 348 articles, of which seven studies met our inclusion criteria (the number of primary vaccinations and re-vaccinations were reported, sufficient data were provided to calculate complication or case-fatality risks, and comparable case definitions were used). For each complication, we estimated of the complication, @entity2 , and case-fatality risks. RESULTS: The life-threatening complications of post-vaccinial @entity1 and @entity5 were at least 3 and 1 per million primary vaccinations, respectively. Twenty-nine percent of vaccinees with post-vaccinial @entity1 died and 15% with @entity5 died. There were no deaths among vaccinees that developed @entity6 ; however, 2.3% of non-vaccinated contacts with @entity6 died. Among re-vaccinees, the risk of post-vaccinial @entity1 was reduced 26-fold, the risk of @entity5 was reduced 29-fold, and the risk of @entity6 was reduced 12-fold. However, the risk reductions of accidental @entity3 were modest (3.8 and 1.5 fold respectively).

title: Risks of serious complications and XXXX from @entity4 vaccination: a systematic review of the United States experience, 1963-1968.

answer: @entity2


abstract: A @entity0 with @entity3 and anti-I antibody was studied. The titer of the patient's serum at 4 degrees C was 700 with adult I RBC, 256 with cord RBC, 256 with adult i RBC. At room temperature the titers were decreased and the serum also reacted at a titer of 4,000 with enzyme treated adult I RBC. @entity2 treatment of the serum and purified antibody decreased reactivity only slightly, indicating that the antibody was IgG. The heat eluate contained 1.2 mg/ml IgG kappa, but only 80 micrograms/ml IgM kappa. A hybridoma made by fusing the @entity0 's peripheral blood lymphocytes with a @entity0 @entity1 cell line contained only IgM kappa (30 micrograms/ml) anti-I activity. The IgM fraction of the heat eluate reacted similarly to the hybridoma supernatant. The IgG fraction resembled the serum and heat eluate. In this case study, IgG kappa and IgM kappa immunoglobulins, both possessing cold agglutinin activity, were present in the patient's serum. This finding is unusual in @entity3 and in view of the predominance of an IgG cold agglutinin, splenectomy was recommended for treatment.

title: A combination of IgG and IgM autoantibodies in XXXX : immunologic studies and response to splenectomy.

answer: @entity3


abstract: Non-digestible oligosaccharides (NDO) were shown to reduce @entity1 in experimental @entity4 , but it remains unclear whether microbiota changes mediate their @entity4 -modulating effects. This study assessed intestinal microbiota and intestinal @entity1 after feeding chemically defined AIN-76A or @entity2 chow diets, with or without supplementation with 8 g/kg body weight of fructo-oligosaccharides (FOS) or isomalto-oligosaccharides (IMO). The study used HLA-B27 transgenic @entity2 , a validated model of @entity0 ( @entity0 ), in a factorial design with 6 treatment groups. Intestinal @entity1 and intestinal microbiota were analysed after 12 weeks of treatment. FOS and IMO reduced @entity4 in animals fed @entity2 chow, but exhibited no anti-inflammatory effect when added to AIN-76A diets. Both NDO induced specific but divergent microbiota changes. Bifidobacteria and Enterobacteriaceae were stimulated by FOS, whereas copy numbers of Clostridium cluster IV were decreased. In addition, higher concentrations of total @entity10 (SCFA) were observed in cecal contents of @entity2 on @entity2 chow compared to the chemically defined diet. AIN-76A increased the relative proportions of @entity6 , @entity9 , valerate and @entity7 irrespective of the oligosaccharide treatment. The SCFA composition, particularly the relative concentration of @entity9 , @entity8 and @entity7 , was associated (P  <= 0.004 and r >=  0.4) with @entity4 and @entity5 concentration of the cecal mucosa. This study demonstrated that the protective effects of fibres on @entity4 development depend on the diet. Although diets modified specific cecal microbiota, our study indicates that these changes were not associated with @entity4 reduction. Intestinal @entity1 was positively correlated to protein fermentation and negatively correlated with @entity3 fermentation in the large intestine.

title: Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic XXXX .

answer: @entity2


abstract: BACKGROUND: Bariatric procedures can induce a massive @entity4 that lasts for >15 years after surgery; in addition, they achieve important metabolic effects including @entity2 resolution in the majority of morbidly @entity3 @entity0 . However, some bariatric interventions may cause @entity5 and other serious complications. The aim of our study is to evaluate the risk of @entity1 after bariatric surgery. METHODS: We conducted a review of the literature about the cases of @entity6 arising after any bariatric procedure, including a case of @entity7 incidentally discovered by the authors 6 months after laparoscopic adjustable gastric banding. RESULTS: Globally, 17 case reports describing 18 @entity0 were retrieved, including the case study by the authors. The diagnosis of @entity1 was at a mean of 8.6 years after bariatric surgery, 9.3 years after RYGB, and 8.1 years after restrictive procedures. The @entity7 represented most cases (15 @entity0 , 83%). In the @entity0 with RYGB, the @entity7 was localized in the excluded stomach in 5 @entity0 (83%) and in the pouch in 1 @entity0 (17%). After a restrictive procedure, the @entity1 was localized in the pouch in 5 @entity0 (62.5%), in the pylorus in 2 @entity0 (25%), and in lesser curvature only in 1 @entity0 (12.5%). CONCLUSIONS: There is a lack of evidence about a connection between the late occurrence of @entity6 and the bariatric surgery. For this reason, although the preoperative @entity8 is still mandatory, there is no need for a regular endoscopic evaluation of @entity0 after surgery.

title: XXXX following bariatric surgery: a review.

answer: @entity6


abstract: UNASSIGNED: The therapeutic strategy to be recommended in case of recurrent or persistent @entity1 after completed definitive chemoradiotherapy (dCRT) has to be documented. Salvage esophagectomy has traditionally been recognized as a viable option, but many clinicians oppose the use of surgery due to the associated excessive morbidity and mortality. 'Second-line' chemoradiotherapy (CRT) without surgery may offer a treatment alternative in these difficult and demanding clinical situations. Until now, no comprehensive attempt has been carried out to compare the respective therapeutic options. A systematic literature search was performed focusing on studies comparing survival and treatment-related mortality in @entity0 submitted to salvage esophagectomy or second-line CRT for recurrent or persistent @entity2 after dCRT. Hazard ratios and risk ratios were calculated to compare the effect of these therapeutic strategies on overall survival and treatment-related mortality, respectively. Four studies containing 219 @entity0 , with persistent or recurrent @entity2 after dCRT, were included in the meta-analysis. The analysis revealed an overall survival benefit following salvage esophagectomy with a pooled hazard ratio for death of 0.42 (95% confidence interval 0.21-0.86, P = 0.017) compared with second-line CRT. A treatment-related mortality of 10.3% was recorded in the 36 @entity0 who were submitted to salvage esophagectomy, while it was impossible to perform a meta-analysis comparing treatment-related mortality between the groups. Salvage esophagectomy offers significant gain in long-term survival compared with second-line CRT, although the surgery is potentially at a price of a high treatment-related mortality.

title: Systematic review and meta-analysis on the significance of salvage esophagectomy for persistent or recurrent XXXX after definitive chemoradiotherapy.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Acute vertebrobasilar @entity2 is often associated with high morbidity and mortality with limited therapeutic options. Endovascular treatment with thrombolysis has offered some hope for affected @entity0 ; however, overall outcomes have been less than satisfactory. In this report, we present the results of our approach in six consecutive cases of acute vertebrobasilar @entity2 by combined proximal vessel stent placement and thrombolysis. METHODS: Six consecutive cases were retrospectively reviewed for the clinical outcome of @entity0 presenting to our institution with acute posterior circulation @entity1 who underwent cerebral revascularization including proximal arterial stent placement by using balloon-expandable coronary stents and intraarterial thrombolysis. All of these @entity0 were initially evaluated by @entity1 team neurologists and imaged with MR, including diffusion-weighted imaging documenting acute posterior circulation @entity1 . MR angiography of the circle of Willis was also obtained. Short-term follow-up was conducted to assess National Institutes of @entity1 scores (NIHSS) and modified Rankin scores. RESULTS: In these six cases, a combined approach of proximal arterial stent placement (five cases of vertebral artery origin and one case of carotid and subclavian stent placement plus vertebral artery revascularization) and thrombolysis was performed at variable times after @entity1 onset (range, 30 hours to 5 days). Four of the six @entity0 had good basilar artery recanalization (Thrombolysis in @entity3 [TIMI] grade 0-1 before tissue plasminogen activator thrombolysis and TIMI grade 2 after procedure). Four of six @entity0 had excellent immediate recovery and were discharged to an acute rehabilitation unit or their homes with improved neurologic symptoms and functional status. Two @entity0 died: one @entity0 presented with @entity4 at outset with an NIHSS of 38, and the other @entity0 probably had reocclusion of the basilar artery within 24 hours despite initial postprocedural improvement. CONCLUSION: We demonstrate that, in the setting of @entity1 , stent placement in combination with revascularization and thrombolysis is practical and allows quick access to a clot and simultaneously increases perfusion through collaterals during the thrombolytic process. In particular, basilar thrombolysis may be facilitated by proximal vertebral stent placement as concomitant @entity5 is common.

title: Combined stent placement and thrombolysis in acute vertebrobasilar XXXX .

answer: @entity2


abstract: PURPOSE: To assess the efficacy of a concomitant boost fractionation schedule of radiotherapy for treating @entity0 with @entity5 of the tonsillar fossa. @entity0 AND METHODS: Between December 1983 and November 1992, 83 @entity0 with @entity5 of the tonsil were treated with concomitant boost fractionation. The distribution of American Joint Committee on @entity1 stages was TX-4, T1-5, T2-29, T3-41, T4-4; N stages were NX-1, N0-26, N1-13, N2-31, N3-12. @entity0 were treated with standard large fields to 54 Gy in 6 weeks. The boost treatment consisted of a second daily 1.5 Gy fraction for 10-12 fractions, usually delivered during the final phase of treatment. The @entity1 dose was 69-72 Gy, given over 6 weeks. Twenty-one @entity0 , who all had N2 or N3 regional disease, underwent neck dissections, either before (13 @entity0 ) or 6 weeks after radiotherapy (8 @entity0 ); the other @entity0 were treated with radiotherapy alone. RESULTS: The 5-year actuarial disease-specific survival and overall survival rates were 71 and 60%, respectively. @entity0 with T2 and T3 @entity1 had 5-year actuarial local control rates of 96 and 78%, respectively. @entity0 with T3 disease who received the final-phase boost had a 5-year actuarial local control rate of 82%. Actuarial 5-year regional disease control rates were N0, 92%; N1, 76%; N2, 89%; and N3, 89%. The 21 @entity0 who had neck dissections all had their disease regionally controlled. @entity0 presenting with @entity3 or after a node excision who were treated with radiation alone had a 5-year actuarial regional disease control rate of 79%. All but five @entity0 had confluent Grade 4 @entity2 during treatment. Severe late complications attributable to radiation included mandibular necrosis [1], in-field @entity4 [1], and chronic @entity6 for solid foods [5]. CONCLUSIONS: High rates of local and regional disease control were achieved with the concomitant boost fractionation schedule, with few cases of severe late morbidity. @entity0 with N2 and N3 neck disease were effectively treated with radiation and the selective use of neck dissections. The concomitant boost schedule is our preferred fractionation approach for treating @entity0 with intermediate stage tonsil @entity1 who are not participating in our current research protocols.

title: Concomitant boost radiotherapy for XXXX of the tonsillar fossa.

answer: @entity5


abstract: BACKGROUND: @entity0 with a severe @entity2 ( @entity2 ) often experience problems understanding non-literal utterances such as sarcasm and lies in dyadic exchanges. This study aimed to investigate whether these problems extend to settings where speakers vary in their degree of sincerity and whether such problems are associated with @entity1 (emotion perception, theory of mind, and self-reported empathy) or cognitive abilities (abstract reasoning, working memory, processing speed, attentional switching). METHODS: Thirty-one adults with severe @entity2 (24 males) and 25 demographically matched controls (20 males) participated. They watched video vignettes depicting four actors volunteering for additional duties. Each speaker made a limited verbal response which literally suggested a willingness to be involved, but the sincerity with which the response was made was tempered by the actor's emotional demeanour. @entity0 rated each speaker in the vignettes for degree of sincerity (0-100%). Standardized measures of @entity1 were also taken. RESULTS: Control @entity0 had excellent agreement (a  =  .90) in their rankings of actors according to sincerity. @entity2 @entity0 were less consistent (a  =  .65). Overall, they were sensitive to decreasing sincerity but generally less accurate than control @entity0 . They were poorer at differentiating between levels of sincerity and rated insincere expressions as more sincere, although they rated sincere expressions similarly. Poorer working memory and poorer social cognition were associated with poorer sincerity/sarcasm detection in the @entity0 with @entity2 , but only social cognition was uniquely associated. CONCLUSIONS: Some adults with @entity2 have difficulty assessing the level of sincerity of speakers. Moreover, poorer social cognition abilities are associated with this difficulty.

title: XXXX of sincerity after severe @entity2 .

answer: @entity1


abstract: BACKGROUND: Few studies of @entity0 with @entity3 ( @entity3 ) have been conducted. Choice of treatment remains controversial. METHODS: The authors analyzed data on 199 evaluable esophageal @entity3 @entity0 , selected from among 230 @entity0 found in the literature, and a data extraction form that recorded 11 features was completed. To allow for the evaluation of prognostic factors that influenced survival, the @entity0 were grouped according to @entity1 ( @entity1 ), which was defined as disease confined to the esophagus, or @entity1 ( @entity1 ), which was defined as disease that had spread beyond locoregional boundaries. Univariate and multivariate analyses were performed. Treatment was categorized as either local or local with systemic; for the @entity1 cases, the categories were defined as treatment versus no treatment. RESULTS: The @entity1 site was described in 178 cases (89%). Mean @entity1 size was 6.1. Pure @entity3 was found in 137 cases (68.8%), whereas 62 cases (31.2%) showed mixed @entity3 ; 93 (46.7%) were @entity1 , whereas 95 (47.7%) were @entity1 . In 11 cases (5.5%), the stage was not determined. There was a significant difference in survival between @entity0 with @entity1 and those with @entity1 (P < 0.0001). The median survival was 8 months for @entity0 with @entity1 and 3 months for those with @entity1 . Univariate analysis of @entity1 showed 3 significant prognostic factors: age (for @entity0 age < or =60 years, the median survival was 11 months, whereas for those age >60 years, the median survival was 6 months), @entity1 size (for those with @entity1 < or =5 cm, the median survival was 12 months, whereas for those with @entity1 >5 cm, the median survival was 4 months), and type of treatment (with local plus systemic treatment, the median survival was 20 months, whereas with local it was 5 months). In multivariate analysis, @entity1 size (P = 0.007) and type of treatment (P < 0.001) were shown to be independent predictive variables. CONCLUSIONS: Esophageal @entity3 is an @entity2 . This study shows that there are significant differences between @entity1 and @entity1 and that in @entity1 , both @entity1 size and type of treatment are possible prognostic factors.

title: XXXX of the esophagus: a review of the literature with emphasis on therapy and prognosis.

answer: @entity3


abstract: AIM: The aim of this study was to examine the relationship between @entity4 , repeat biopsies and other demographic and clinical factors in @entity0 on @entity8 ( @entity8 ). METHODS: @entity0 -reported outcomes (PROs) measures were administered at enrollment and every 6 months to assess quality of life (QOL), psychosocial and urological health outcomes. Using mixed-effects models, we examined the impact of repeat biopsies, total number of cores taken, @entity3 , age, and comorbidity on sexual function over the first 24 months of enrolling in @entity8 . MAIN OUTCOME MEASURES: PROs included the Expanded @entity5 Index Composite-26 (EPIC-26) Sexual Function (SF) subscale, the American Urological Association-Symptom Index (AUA-SI), and the Memorial @entity3 Scale for @entity5 (MAX-PC). RESULTS: At enrollment (n   =   195), mean age was 66.5        6.8 with a mean EPIC-26 SF score of 61.4        30.4. EPIC-26 SF scores steadily decreased to 53.9        30.7 at 24 months (P   <   0.01). MAX-PC scores also progressively decreased over time (P   =   0.03). Factors associated with lower EPIC-26 scores over time included age, unemployed status, @entity1 , @entity6 , and @entity2 (all P   <   0.05). Higher @entity7 (PSA) was associated with a more rapid decline in EPIC-26 SF over time (P   =   0.03). In multivariable analysis, age, @entity1 , and PSA   *   time interaction remained significant predictors of diminished sexual function. @entity3 , number of biopsies, and total cores taken did not predict @entity4 or change over time in our cohort. CONCLUSIONS: @entity0 on @entity8 experienced a gradual decline in sexual function during the first 24 months of enrollment. Older age, PSA   *   time, and @entity1 were all independent predictors of diminished sexual function over time. @entity3 , AUA-SI, the number of cores and the number of biopsies were not predictors of reduced sexual function in @entity0 in @entity8 .

title: A Longitudinal Study of Predictors of @entity4 in @entity0 on Active Surveillance for XXXX .

answer: @entity5


abstract: We have identified an @entity0 mutant that displays enhanced disease resistance to the fungus Erysiphe cichoracearum, causal agent of powdery mildew. The @entity6 mutant does not constitutively express the pathogenesis-related genes @entity4 , @entity5 , or @entity3 and thus differs from previously described disease-resistant mutants of @entity0 . E. cichoracearum conidia (asexual spores) germinated normally and formed extensive hyphae on @entity6 plants, indicating that the initial stages of infection were not inhibited. Production of conidiophores on @entity6 plants, however, was <16% of that observed on wild-type @entity0 . Reduction in sporulation correlated with a more rapid induction of defense responses. Autofluorescent compounds and callose accumulated in @entity6 leaves 3 days after inoculation with E. cichoracearum, and dead mesophyll cells accumulated in @entity6 leaves starting 5 days after inoculation. Macroscopic patches of dead cells appeared 6 days after inoculation. This resistance phenotype is similar to that conferred by "late-acting" powdery mildew resistance genes of @entity2 and @entity1 . The @entity6 mutation is recessive and maps to chromosome 1 between molecular markers ATEAT1 and NCC1. We speculate that the @entity6 mutation derepresses multiple defense responses, making them more easily induced by virulent pathogens.

title: An XXXX mutant with enhanced resistance to powdery mildew.

answer: @entity0


abstract: BACKGROUND: The authors' earlier retrospective report of surgical complications after abdominal contouring surgery provided evidence that post-bariatric surgery @entity0 are at increased risk of developing wound complications compared with a normal population. This prospective pilot study was designed as a comparative analysis of both surgical and wound healing characteristics between massive @entity1 and normal @entity0 who present for abdominal contouring surgery. METHODS: Excisional wounds were created and @entity2 tubing was inserted during the preoperative period for later harvesting in @entity0 undergoing abdominal contouring following Roux-en-Y gastric bypass for @entity1 (n = 16) or abdominoplasty (n = 17). Wound fluids were sequentially collected from drains and subjected to matrix metalloproteinase (MMP) analysis. Standard postsurgical complications were documented. RESULTS: Surgical complications were more common in @entity1 @entity0 (47 percent) than in control @entity0 (25 percent). MMP analyses showed that @entity3 levels remained significantly elevated at postoperative day 4 in @entity0 who subsequently experienced complications in either the @entity1 group (p = 0.02) or the control group (p = 0.03). Other parameters showed no significant differences between massive @entity1 @entity0 and controls. CONCLUSIONS: Although many markers were examined, the ratio of @entity3 to albumin was the only predictor of postsurgical complications in any group. This lends further support to growing evidence that @entity3 may be a useful biomarker of postsurgical complications. This pilot work showed no causal factors that explain the higher rates of postsurgical complications in the post-bariatric surgery @entity0 population. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, II.

title: The correlation of XXXX -to-albumin ratio in wound fluid with postsurgical complications after body contouring.

answer: @entity3


abstract: @entity0 with @entity3 also have respiratory problems in sleep. The continuous acoustic lung sound detection together with a cardiorespiratory polysomnography allows a synchronous registration of @entity2 as well as vigilance and respiratory parameters in sleep.A total of 20 @entity0 (9 male and 11 female) with @entity1 and evident diurnal @entity2 were investigated. We did a monitoring in all @entity0 with a nocturnal continuous acoustic lung sound detection together with a cardiorespiratory polysomnography. The mean age was 55 +/- 12 years (range 23 to 74). In all @entity0 acoustic nocturnal @entity2 could be registered. The wheezing-time (time portion of wheezing while sleeping) was 32.1 +/- 27.4 % (mean +/- SD). We could not proof reliable a rhythm of @entity2 . Only 3 @entity0 had increased @entity2 between 3 and 5 AM. The sleep structure was disturbed in 16 of 20 @entity0 with reduced deep sleep, REM sleep and prolonged sleep latency. Knowing about nocturnal @entity2 helps to adapt the antiobstructive therapy. One can expect that an improvement of the respiratory situation also improves sleep quality.

title: [Acoustic analysis of nocturnal XXXX ].

answer: @entity2


abstract: Perturbations of the trans-sarcolemmal and sarcoplasmic @entity0 transport contribute to the abnormal myocardial activity provoked by @entity2 and reoxygenation. Whether @entity0 pools of the extracellular compartment and sarcoplasmic reticulum (SR) are involved to the same extent in the @entity1 of the anoxic-reoxygenated immature heart has not been investigated. Spontaneously contracting hearts isolated from 4-day-old @entity4 embryos were submitted to repeated @entity2 (1 min) followed by reoxygenation (5 min). Heart rate, atrioventricular propagation velocity, ventricular shortening, velocities of contraction and relaxation, and incidence of @entity3 were studied, recorded continuously. Addition of @entity5 (10 nM), which blocks selectively sarcolemmal L-type @entity0 channels, was expected to protect against excessive entry of extracellular @entity0 , whereas addition of @entity6 (10 nM), which opens the SR @entity0 release channel, was expected to increase cytosolic @entity0 concentration. @entity5 (a) had no dromotropic effect by contrast to adult heart, (b) attenuated ventricular contracture induced by repeated @entity2 , (c) shortened cardioplegia induced by reoxygenation, and (d) had remarkable antiarrhythmic properties during reoxygenation specially. On the other hand, @entity6 potentiated markedly @entity3 both during @entity2 and at reoxygenation. Thus despite its immaturity, the SR seems to be functional early in the developing @entity4 heart and involved in the reversible @entity1 induced by @entity2 -reoxygenation. Moreover, @entity0 entry through L-type channels appears to worsen @entity3 especially during reoxygenation. These findings show that the @entity0 -handling systems involved in irregular activity in immature heart, such as the embryonic @entity4 heart, may differ from those in the adult.

title: Effects of @entity5 and XXXX on activity of the embryonic @entity4 heart during @entity2 and reoxygenation.

answer: @entity6


abstract: UNASSIGNED: 49 Background: Melanoma has a poor survival rate in advanced stages due to the lack of efficacious approved treatments. However, @entity3 's dermal location enables the application of @entity0 skin models. These models mimic many important characteristics of skin in vivo and obviate the use of invasive procedures. Monitoring gamma-H2AX foci to assess DNA double-strand break (DSB) levels in reconstituted @entity0 3D skin tissue harboring @entity3 cells may provide insights into important questions in @entity1 research. In addition to the differential toxicities of anti- @entity1 agents on the various cell types, we examine how the early drug response of normal tissues might serve as surrogates for predicting treatment efficacy on the @entity1 . METHODS: Commercially available reconstituted 3D human skin tissue consists of dermal fibroblast and epidermal keratinocyte layers with @entity3 A375 cells which have been cultured to form a multilayer, highly differentiated epidermis containing various stages of cutaneous @entity3 . Drugs representative of several different categories were studied, including @entity6 (a radiomimetic), @entity9 (a topoisomerase I inhibitor), @entity7 (a DNA alkylating agent), @entity10 (a @entity8 inhibitor), @entity4 (a HDAC inhibitor) and @entity5 (a DNA intercalatingagent). DNA DSB levels were monitored by gamma-H2AX foci formation and apoptosis by TUNEL assay. @entity1 growth was monitored by H_E staining. RESULTS: A wide range of responses in both @entity1 and normal tissue by various drugs were observed, including @entity1 regression and normal tissue @entity2 . The early responses of normal tissues depended on the treatment, providing insights into the use of surrogate tissues as predictors of drug efficacy and later @entity1 regression. CONCLUSIONS: Measuring DNA DSB damage in reconstituted 3D skin tissue is an attractive model for studying the efficacy and @entity2 of genotoxic drugs against @entity3 . If validated, such models would help reduce the use of animals for preclinical studies.

title: Examining the reliability of surrogate tissue predictability of drug efficacy in reconstituted @entity0 3D skin models containing XXXX .

answer: @entity3


abstract: Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether @entity4 lignans (sesamin/episesamin=1/1, 10 mg) with @entity1 (55 mg of @entity3 ) (SVE) could improve subjective statuses and anti-oxidative capacity in @entity0 using questionnaires on @entity2 , sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily @entity2 . After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding @entity2 , sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in @entity2 status at 4 and 8 weeks compared to 0 weeks in both groups (p<0.01), and sleep and physical appearance at 8 weeks compared to 0 weeks only in the SVE group (p<0.01). There were no significant differences observed between the groups. According to the 72-subject subgroup analysis (aged 40 and over), the sleep and physical appearance significantly improved compared to the P group (p<0.05), and @entity2 status showed a tendency for improvement compared to the P group. Anti-oxidative capacity in the SVE group significantly increased compared to the P group (p<0.01). No adverse events relating to SVE supplementation were confirmed. These results suggest SVE supplementation could safely alleviate daily @entity2 and oxidative stress.

title: @entity4 Lignans and @entity1 Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy XXXX With Feelings of Daily Fatigue.

answer: @entity0


abstract: @entity0 in intensive care units (ICU) are at risk of @entity2 . The incidence of @entity1 has increased in parallel with the increase of @entity2 . @entity5 is the most frequent pathogenic species among the fungi. The aim of this study was to make an epidemiological surveillance of @entity5 urine isolates which were isolated from @entity0 who were hospitalized in ICU between June 2000 and October 2001 by antifungal susceptibility testing and Randomly Amplified Polymorphic DNA (RAPD) analysis. For this purpose, 38 @entity5 which were isolated from 29 @entity0 were investigated for @entity3 and @entity4 susceptibility with the microdilution method. The range of minimal inhibitory concentration (MIC) of @entity3 was between 0.25-1 microgram/ml and MIC50 value was 0.5 microgram/ml and none of the isolates had high (MIC > 1 microgram/ml) MIC values. The MIC values for @entity4 varied between 0.25-16 micrograms/ml and MIC50 value was 1 microgram/ml. While none of the isolates was resistant to @entity4 , two isolates were detected as dose dependent susceptible. RAPD analysis was performed with two different primers in order to investigate clonal relationship, and 22 patterns were detected with one of the primers and 24 patterns were detected with the other. In conclusion, it is thought that the origin of the @entity5 urine isolates were mostly endogenous but exogenous spread might also be considered as isolates that were clonally related were isolated from different @entity0 at the same time interval.

title: [Molecular epidemiologic surveillance and antifungal agent sensitivity of XXXX isolated from anesthesia intensive care units].

answer: @entity5


abstract: BACKGROUND: @entity4 is a common consequence of @entity5 ( @entity5 ). No therapeutic drugs or drug groups are proven to be superior for @entity1 and treatments only aim to convert @entity2 from dull to tolerable levels and not to remove it. OBJECTIVE: This study was planned to compare the effect of @entity3 ( @entity3 ) and Transcutaneous electrical nerve stimulation (TENS) on @entity2 intensity, @entity2 quality and functional capacity in @entity5 @entity0 with @entity1 . METHODS: Twenty-four @entity0 were included and randomly categorized into two groups. In the first group (n=12), @entity3 was applied for first two weeks, 1 week wash out period and then TENS was applied for 2 weeks. In second group (n=12), TENS was applied firstly, 1 week wash out and then @entity3 were applied. @entity2 severity, @entity2 quality, and functional capacity were assessed with the visual analog scale (VAS), the @entity1 ( @entity1 ), and the Brief @entity2 Inventory (BPI), respectively. A pre-post-treatment and cross over design was used. RESULTS: Wilcoxon signed-rank tests were used for within group analyses. Mann-Whitney U tests were used for analyses that compared different groups. It was observed that @entity2 intensity decrease immediately after both applications ( @entity3 : p=0.07, TENS: p=0.08). After TENS application for 2 weeks, it was observed that significant decrease in most (p=0.04) and less (p=0.02) @entity2 intensity; while there was no significant decrease in @entity2 intensity after 2 weeks for @entity3 (p> 0.05). When findings of @entity1 were analyzed, hot (p=0.047), sharp (p=0.02), unpleasant (p= 0.03) and deep items (p=0.047) decreased after @entity3 application. When the results of BPI were detected, they were observed that the negative effect of @entity2 on moving ability (p=0.04) after @entity3 application and the negative effect of @entity2 on mood (p=0.03), relationships with others (p=0.04) and sleep (p=0.04) after TENS application decreased significantly.CONCLUSION: TENS and @entity3 therapies can be successfully used in clinical practice as an alternative treatment or as a supportive method separetely or together.

title: Effects of XXXX and transcutaneous electrical nerve stimulation on @entity1 in @entity0 with @entity5 : A randomised controlled cross-over trial.

answer: @entity3


abstract: UNASSIGNED: @entity6 ( @entity6 ) typically arises from skeletal muscle. Currently, @entity6 in @entity0 with recurrent and @entity1 have no successful treatment. The molecular pathogenesis of @entity6 varies based on @entity2 sub-types. Some embryonal @entity6 but not other sub-types are driven by sonic hedgehog ( @entity11 ) signaling pathway. However, @entity11 pathway inhibitors particularly smoothened inhibitors are not highly effective in animals. Here, we show that @entity11 pathway effectors @entity12 and/or @entity7 are over-expressed in the majority of @entity6 cells and that @entity15 , a specific @entity16 inhibitor dampens the proliferation of both embryonal and alveolar @entity6 cells-derived xenograft @entity2 thereby blocking their growth. As compared to vehicle-treated control, about 50% @entity2 growth inhibition occurs in @entity3 receiving @entity15 treatment. The proliferation inhibition was associated with slowing of cell cycle progression which was mediated by the reduced expression of cyclins @entity14 and the concomitant induction of @entity10 . @entity15 not only reduced expression of @entity16 in these @entity6 but also significantly diminished @entity5 / @entity9 signaling. The therapeutic action of @entity15 was significantly augmented when combined with chemotherapeutic agents employed for @entity6 therapy such as @entity13 or @entity8 . Finally, reduced expression of proteins driving epithelial mesenchymal transition (EMT) characterized the @entity4 .

title: GLI inhibitor @entity15 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting XXXX / @entity5 - @entity9 axis.

answer: @entity11