abstract: BACKGROUND: @entity1 ( @entity1 ) is the most common form of @entity2 in @entity0 with Down Syndrome (DS). @entity3 is a chemical found in the brain that has an important role in memory, attention, reason and language. @entity4 is a "pseudo-irreversible" inhibitor of acetylcholinesterase, which is thought to maintain levels of @entity3 . @entity4 can improve cognitive function and slow the decline of @entity1 in the general population over time. It is important to note that @entity0 with DS tend to present with @entity1 at a much younger age than the normal population as well as having subtle differences in physiology (e.g. metabolism and heart rate) and may therefore have different requirements from the general population. OBJECTIVES: To determine the effectiveness and safety of @entity4 for @entity0 with DS who develop @entity1 . SEARCH STRATEGY: CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, BIOSIS, SCI, SSCI and the NRR were searched up to October 2008. We contacted the manufacturers of @entity4 as well as experts in the field, to ask about reports of unpublished or ongoing trials. SELECTION CRITERIA: Randomised controlled trials of @entity0 with DS and @entity1 in which treatment with @entity4 was administered compared with a placebo group. DATA COLLECTION AND ANALYSIS: No study was identified which met inclusion criteria for this review. MAIN RESULTS: No study was identified which met inclusion criteria for this review. AUTHORS' CONCLUSIONS: As there are no included trials, recommendations cannot be made about @entity4 for @entity1 in DS. Well-designed, adequately powered studies are required.

title: @entity4 for XXXX in @entity0 with Down syndrome.

answer: @entity2


abstract: BACKGROUND: Although the occurrence of @entity8 ( @entity8 ) after chemotherapy for @entity5 ( @entity5 ) is common in clinical settings, the simultaneous occurrence of these @entity1 in @entity0 without previous exposure to chemotherapy is a rare event. Etiology, disease management, and clinical treatment remain unclear for this particular occurrence. To the best of our knowledge, this study is the first to report a case of simultaneous presentation of @entity8 and @entity5 after exposure to ultraviolet irradiation. CASE PRESENTATION: We reported the case of a 73-year-old @entity0 (Han Chinese ethnicity) without previous medical history of @entity8 and @entity5 . The morphology and immunology of bone marrow cells confirmed the co-existence of @entity8 and @entity5 . Fluorescent in situ hybridization analysis of immunomagnetically separated abnormal plasma cells showed abnormal expression of the amplified @entity3 , @entity2 , and @entity10 (1p32). Cytogenetic analysis demonstrated Y chromosome deletion. After the @entity0 was administered with @entity6 combined with @entity7   +   @entity9   +   @entity4 (CAG regimen), and evident curative effects were observed. The @entity0 achieved and maintained complete remission for more than 6  months. Prior to the disease occurrence, the @entity0 had received ultraviolet irradiation for 1  year and was detected with aberrant gene expression of @entity3 , @entity2 , and @entity10 (1p32). Nevertheless, the correlation of this phenomenon with the etiology of concurrent @entity8 with @entity5 remains unclear. CONCLUSION: This study discussed the case of a @entity0 diagnosed with @entity8 concurrent with @entity5 , who has no previous exposure to chemotherapy. This @entity0 was successfully treated by @entity6 combined with CAG regimen. This study provides a basis for clinical treatment guidance for this specific group of @entity0 and for confirmation of the disease etiology.

title: A case of simultaneous occurrence of @entity8 and XXXX .

answer: @entity5


abstract: AIM: To describe the long-term experience of a simplified frozen @entity8 trunk technique (sFETT) used in complicated acute @entity7 (AAAD) treatment. METHODS AND RESULTS: Between January 2001 and December 2012, 34 @entity0 (mean age 59.9        11.0 years) with complicated AAAD (DeBakey I) underwent an emergency surgery including sFETT. sFETT consisted in gluing the dissected aortic arch wall layers with gelatine- @entity9 adhesive and video-assisted antegrade open arch aortic stent-graft deployment in the arch or proximal descending aorta. In addition to sFETT, the aortic root was addressed with standard techniques. A 30-day mortality was 14.7% (five @entity0 ) due to bleeding (1), @entity6 (2), and @entity2 (2). Postoperative morbidity included @entity1 (4), as well as wound infection (1). Mean follow-up was 74.4        45.0 months. Actual survival rates were 73.5% at 1 year, 70.2% at 5 years, and 58.5% at 13 years of follow-up. Six @entity0 died during long-term follow-up from @entity5 (1) and unknown reasons (5). Five @entity0 required reoperation for aortic arch (3) or aorto-iliac (2) progression of @entity4 during the mid- and long-term follow-up. The remaining @entity0 showed favorable evolution of the dissected aorta with false @entity3 in most cases and stable aortic diameters. CONCLUSIONS: In AAAD @entity0 , sFETT as used in our series is an easy and safe technique to repair the aortic arch. Long-term results after sFETT showed false @entity3 and stable aortic diameter in up to 13 years of follow-up.

title: Long-term results of simplified frozen @entity8 trunk technique in complicated acute XXXX : A case-control study.

answer: @entity7


abstract: BACKGROUND: A progressive reduction in the speed and amplitude of repetitive action is an essential component of @entity6 , which is called @entity7 ( @entity7 ). Because @entity7 is specific to @entity2 ( @entity2 ) and is suggested to be associated with @entity4 , its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of @entity7 and to demonstrate whether dopaminergic deficit is correlated with @entity7 . METHODS: We enrolled 12 @entity0 with de novo @entity2 at a tertiary referral hospital. Correlations between @entity7 severity and alterations in gray and white matter were studied. The association between severity of the @entity1 was also analyzed. RESULTS: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of @entity7 . There was a significant correlation between the long association fibers (the superior @entity5 ) connecting the frontal lobes to the temporal, parietal, and occipital lobes and @entity7 . There was a significant negative correlation between @entity7 in the more affected hand and the caudate @entity3 transporter binding in the more affected hemisphere. CONCLUSIONS: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of @entity7 . Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to @entity7 .

title: Neural correlates of progressive reduction of @entity6 in de novo XXXX .

answer: @entity2


abstract: OBJECTIVES: Lung-preserving surgery was proved to be effective and safe to treat @entity0 with benign bronchial strictures. However, this surgical treatment has been rarely reported in @entity0 with complete occlusion in the left main bronchus. The aim of this study was to assess the value of this procedure and report our experience in the treatment of these @entity0 with left @entity3 caused by inflammatory bronchial occlusion. METHODS: We reviewed and analysed the medical records of 8 @entity0 who had undergone left main bronchus sleeve resection for symptomatic left @entity3 caused by inflammatory bronchial occlusion from May 2007 to April 2011. RESULTS: Eight @entity0 (3 @entity0 and 5 @entity0 ) with a medical history of @entity4 were involved in this study. The median age was 23 years. Parenchyma-sparing left main bronchus resection was performed in 4 @entity0 , 1 of whom received partial wedge resection in the lingual lobe. Left main bronchus sleeve resection plus superior lobectomy was performed in 2 @entity0 and left main bronchus sleeve resection plus left inferior lobectomy in 2 @entity0 , 1 of whom received additional partial wedge resection of the lingual lobe. The procedure was completed successfully in all 8 @entity0 without @entity1 . The mean follow-up time was 49.3 months, ranging from 23 to 69 months. No major complications, including @entity2 and @entity3 , were observed during the follow-up period. The symptoms of @entity3 disappeared and pulmonary ventilation function improved significantly. CONCLUSIONS: In symptomatic @entity0 with left @entity3 caused by inflammatory bronchial occlusion, lung-preserving surgery is an effective and safe surgical treatment.

title: Use of lung-preserving surgery in left inflammatory bronchial occlusion and distal XXXX : preliminary results.

answer: @entity3


abstract: PURPOSE: The expression of @entity5 ( @entity5 ) and @entity0 @entity9 ( @entity9 ) is associated with poor prognosis in sporadic @entity2 ( @entity2 ). @entity5 inhibitors are approved for the treatment of refractory @entity2 . The aim of this study was to investigate the expression of @entity5 and @entity9 and downstream @entity11 ( @entity11 ) and mitogen activated protein kinase (MAPK) in non-neoplastic colonic mucosa, @entity6 and @entity3 from @entity8 ( @entity8 ) @entity0 , exploring the expression along the @entity10 sequence. METHODS: The expression of @entity5 , @entity9 , phosphorylated MAPK/ @entity11 kinase (pMEK) and phosphorylated @entity11 (pERK) proteins was studied by immunohistochemistry in samples of @entity7 (n   =   65), @entity6 (n   =   149) and @entity4 (n   =   16) from each of the 16 @entity8 @entity0 . RESULTS: For @entity9 , only weak cytoplasmic expression was seen in 8% of @entity6 , 6% of @entity3 and 3% of the non-neoplastic mucosa. @entity5 was expressed in non-neoplastic mucosa, @entity6 and @entity3 with a statistically significant increase in expression in @entity6 compared with non-neoplastic mucosa (p   <   0.001). There was also a statistically significant increase in nuclear staining intensity for pERK (p   <   0.001) and pMEK (p   <   0.001) in @entity6 compared to non-neoplastic mucosa. CONCLUSIONS: This is the first study investigating the expression of these receptors in non-neoplastic mucosa, @entity6 and @entity3 from @entity8 @entity0 . @entity9 is not upregulated in the @entity1 of @entity8 @entity0 , while @entity5 appears to be upregulated in most @entity6 and @entity3 , with associated upregulation of pERK and pMEK. We conclude that @entity5 and downstream members of its signalling pathway, but not @entity9 , may be potential therapeutic targets in @entity8 @entity0 .

title: Expression of @entity5 , @entity9 , phosphorylated @entity11 and phosphorylated MEK in @entity7 of @entity8 XXXX .

answer: @entity0


abstract: BACKGROUND: Invasive @entity3 are an important cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation. METHODS: In an international, randomized, double-blind trial, we compared oral @entity6 with oral @entity5 for prophylaxis against invasive @entity3 in @entity0 with @entity4 ( @entity4 ) who were receiving immunosuppressive therapy. The primary end point was the incidence of proven or probable invasive @entity3 from randomization to day 112 of the fixed treatment period of the study. RESULTS: Of a total of 600 @entity0 , 301 were assigned to @entity6 and 299 to @entity5 . At the end of the fixed 112-day treatment period, @entity6 was found to be as effective as @entity5 in preventing all invasive @entity3 (incidence, 5.3% and 9.0%, respectively; odds ratio, 0.56; 95 percent confidence interval [CI], 0.30 to 1.07; P=0.07) and was superior to @entity5 in preventing proven or probable @entity1 (2.3% vs. 7.0%; odds ratio, 0.31; 95% CI, 0.13 to 0.75; P=0.006). While @entity0 were receiving study medications (exposure period), in the @entity6 group, as compared with the @entity5 group, there were fewer @entity3 (2.4% vs. 7.6%, P=0.004), particularly @entity1 (1.0% vs. 5.9%, P=0.001). Overall mortality was similar in the two groups, but the number of @entity2 from invasive @entity3 was lower in the @entity6 group (1%, vs. 4% in the @entity5 group; P=0.046). The incidence of treatment-related adverse events was similar in the two groups (36% in the @entity6 group and 38% in the @entity5 group), and the rates of treatment-related serious adverse events were 13% and 10%, respectively. CONCLUSIONS: @entity6 was similar to @entity5 for prophylaxis against @entity3 among @entity0 with @entity4 . It was superior in preventing @entity1 and reducing the rate of @entity2 related to @entity3 . (ClinicalTrials.gov number, NCT00034645 [ClinicalTrials.gov].).

title: @entity6 or XXXX for prophylaxis in severe @entity4 .

answer: @entity5


abstract: HISTORY AND CLINICAL FINDINGS: A 66-year-old @entity0 with known remitting @entity4 episodes was admitted to a psychiatric hospital where a severe major @entity4 was diagnosed. The @entity0 failed to respond to SSRI medication. In addition, she developed a pronounced speech disturbance and @entity11 . Therefore she was referred to the department of neurology 5 months after disease onset. She presented with a @entity2 . Because of a severe @entity9 testing of cognitive functions were impossible. INVESTIGATIONS: EEG revealed a general slowing of the basic activity. Periodic sharp wave complexes were not seen during the entire disease course. Cerebrospinal fluid analysis (CSF) was normal with regard to cell count and blood-csf-barrier function. 14- 3-3 proteins were detected in CSF, and CSF levels of tau-protein and neuron-specific enolase were strongly elevated. A point mutation was detected at codon 196 ( @entity12 ) of the prion proteine gene. In addition, codon 129 was found homozygous for @entity10 . TREATMENT AND COURSE: During the following 10 weeks the @entity0 developed @entity1 , @entity6 and @entity7 mutism. Complications were decubital ulcers and infections of the urinary tract. The @entity6 slightly regressed following treatment with @entity5 . The @entity0 died 9 months after disease onset. CONCLUSION: A rapid disease course and typical changes of surrogate markers in CSF may support the in-vivo diagnosis of @entity8 despite incomplete clinical criteria (e. g. lack of @entity3 ). In such cases, detection of mutations by molecular genetic analysis is of importance to further support the diagnosis of @entity8 .

title: [Clinically atypical XXXX : diagnostic relevance of cerebrospinal fluid markers and molecular genetic analysis?].

answer: @entity8


abstract: BACKGROUND: Giant cell tumor of bone is benign but locally aggressive @entity1 with a tendency for local recurrence. Although various treatment options have been utilized and reported, it remains a difficult therapeutic problem for the orthopedic surgeon. METHODS: We reviewed the results of the treatment of @entity3 in 27 @entity0 . Eleven @entity0 were treated with extended curettage and burring then packing with cement, while 16 @entity0 had wide resection and reconstruction. RESULTS: At an average of 50 months after surgery, the recurrence rate of curettage was 27% and that of wide resection was 6.25%. Two of the three @entity0 who had a recurrence after curettage were treated by a secondary curettage procedure and were later free of disease. Overall, the local control rate after second curettage and packing with cement was 90.9%. There was no @entity2 in the curettage group but @entity2 occurred in 3 @entity0 of the resection group. Eight @entity0 in the curettage group (80%) had an excellent functional result but only 2 @entity0 in the resection group (13%) achieved an excellent result. CONCLUSION: This study demonstrates that either curettage and packing with cement or wide resection are effective in treatment of @entity3 . There is, however, a better functional result after curettage and packing with cement than following wide resection. We recommend curettage and cement packing for @entity3 whenever it is technically feasible.

title: Treatment of XXXX : a comparison of local curettage and wide resection.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) is a typical manifestation of @entity4 vera (PV) or essential thrombocythaemia (ET). The recently discovered JAK2V617F somatic mutation is closely associated with @entity1 ( @entity1 ). We investigated whether @entity2 involving the inferior vena cava (IVC) is also related to the JAK2V617F mutation or @entity1 . METHODS: Blood samples were obtained from 40 IVC @entity2 @entity0 . Fifty-three @entity0 with isolated @entity3 ( @entity3 ) and 20 @entity2 @entity0 served as controls. The presence of the JAK2V617F mutation was assessed by real-time polymerase chain reaction (RT-PCR). RESULTS: The JAK2V617F allele was not detected in any of the IVC @entity2 @entity0 but was detected in one @entity0 (2%) with isolated @entity3 . However, the mutation-carrying @entity0 did not exhibit symptoms of @entity1 . Even after an observation period of 30months, the @entity0 's complete blood cell count did not exhibit any pathology. In contrast, the JAK2V617F allele was detected in four @entity0 with @entity2 (20%) and @entity1 . CONCLUSION: According to our data, there is no evidence that IVC @entity2 is associated with the JAK2V617F mutation or the presence of @entity1 .

title: Inferior vena cava @entity2 and its relationship with the JAK2V617F mutation and XXXX .

answer: @entity1


abstract: AIM: To assess long-term subjective, objective, and urodynamic outcomes of retropubic mid-urethral slings at 13-year follow-up. METHODS: This was a prospective observational study. Consecutive @entity0 with proven urodynamic stress @entity2 were treated with standard retropubic @entity3 ( @entity3 ). @entity0 with mixed @entity2 and/or anatomic evidence of pelvic organ prolapse were excluded. All the included @entity0 underwent preoperative clinical and urodynamic evaluations. During follow-up examinations, @entity0 were assessed for subjective satisfaction and objective cure rates. The Cox model was used in order to investigate factors predicting the risk of recurrent stress @entity2 (SUI), over the study period. RESULTS: Overall, 55 @entity0 were suitable for the analysis. At 13-year follow-up, 47 out of 55 (85.5%) @entity0 declared themselves cured (p-for-trend 0.02) and 48 out of 58 (87.2%) were at least improved (p-for-trend 0.07). No significant deterioration of objective cure rates was observed over time (P   =   0.29). At the time of the last evaluation, 50 out of 55 (90.9%) @entity0 were objectively cured; urodynamic evaluation confirmed this finding in 49 (89.1%) @entity0 . Considering factors predictive of SUI recurrence, we observed that, via multivariate analysis, @entity1 (HR 7.2; P   =   0.01) and maximum detrusor pressure during the voiding phase  <=29   @entity4 O (HR 8.0; P   =   0.01) were the only independent predictors of recurrent SUI. CONCLUSION: Our data confirmed that @entity3 is a highly effective and safe procedure also at 13-year follow-up. Interestingly, we observed a significant decrease of subjective satisfaction over time. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: @entity3 for the treatment of urodynamic stress XXXX : Efficacy and adverse effects at 13-year follow-up.

answer: @entity2


abstract: The purpose of this study was to determine the efficacy and @entity1 of the @entity4 and @entity8 (CF) regimen in @entity0 with newly diagnosed and relapsed/ @entity6 ( @entity6 ). Thirty @entity0 with pathologically confirmed @entity6 were treated with the CF regimen. Ten (33%) had no prior therapy, six (20%) had one previous regimen, and 14 (47%) received two or more prior regimens. Ninety cycles of CF with a median of 3 cycles/ @entity0 (range, 1-5 cycles) were administered to @entity0 with @entity6 . Nine @entity0 (30%) had a complete response (CR) and 10 (33%) had a partial response (PR) for an overall response rate (RR) of 63%. The median failure-free survival (FFS) and overall survival (OS) was 4.8 months and 17.5 months, respectively. When @entity0 were analyzed based upon the number of previous treatments (0, 1, or 2 or more), those with no previous treatment (n=10) had an overall response of 100%, with 70% CR. The median FFS was 28.1 months and the median OS for this group has not been reached at 42.3+ months. Hematologic and @entity1 were the major @entity1 encountered with the CF regimen. Grade 3-4 @entity7 , @entity5 and @entity3 were seen in 50%, 37%, and 36% of @entity0 , respectively. There were 13 episodes of grade 3 @entity2 . There was no treatment related mortality, In conclusion, the high response rate associated with the CF regimen merits further investigation in previously untreated @entity0 with @entity6 , particularly in those who are not candidates for aggressive therapy.

title: @entity4 / XXXX (CF) is active in the treatment of @entity6 .

answer: @entity8


abstract: PURPOSE: This study examined the clinical results of an arthroscopic simple pleated capsular shift to treat severe recurrent @entity3 . METHODS: Twenty-four @entity0 with anterior labroligamentous periosteal sleeve @entity1 or advanced lesions who underwent an arthroscopic simple pleated capsular shift were included in this study. To create an arthroscopic simple pleated capsular shift, redundant capsules, including glenohumeral ligaments, were brought at least 1 cm lateral and 1 cm inferior and shifted to the prepared glenoid. Four sutures were made at the 5, 4, 3, and 1-2 o'clock positions with four anchors. Clinical results were evaluated using a visual analog scale (VAS), ROWE scores, active motion, and return to activity. Statistical analyses were carried out using paired t tests. RESULTS: Three out of 24 @entity0 had complaints. Two @entity0 with recurrent instability underwent a repeat surgery, while the other @entity0 complained of a stiff shoulder. There was a significant improvement in the VAS and ROWE scores post-operatively versus pre-operatively (p < 0.001, p < 0.001, respectively), but no significant differences in active motion except for external rotation, which decreased post-operatively (p = 0.02). CONCLUSIONS: In @entity0 with severe recurrent @entity2 , simple pleated capsular shift provided a reliable result. Four capsular shift sutures, 1 cm lateral and 1 cm inferior from the glenoid, were sufficient to reduce shoulder joint volume and restore stability. The arthroscopic capsular shift could be an alternative method in the case of no available labral lesion for repair. LEVEL OF EVIDENCE: Case series, Therapeutic, Level IV.

title: An arthroscopic pleated capsular shift for recurrent XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity1 is a core feature of @entity4 . Antipsychotics have at best small positive effects on cognitive performance. There is a lack of knowledge regarding the effects of antidepressants on cognitive functioning in these disorders. In the present study cognitive performance was investigated in relation to serum levels of antidepressants in @entity0 with @entity3 and @entity2 . Serum concentrations of @entity5 , @entity5 and @entity6 plus @entity8 were measured in a total of 187 @entity0 with @entity3 (N=74) or @entity2 spectrum disorders (N=113), and analyzed in relation to neuropsychological tests performance of verbal @entity7 , executive functioning and processing speed. Analyses were performed using linear regression adjusting for a range of confounders. There was a significant positive association between the serum level of @entity6 plus @entity8 and verbal memory (immediate recall: Logical Memory Test immediate recall [p=0.015], and long term delayed recall: Logical Memory Test delayed recall [p=0.011]). No significant associations were seen between @entity5 or @entity5 and verbal memory. There were no significant associations between the tested antidepressants and verbal learning, attention, working memory, executive functioning, or processing speed. @entity6 seem to be associated with better verbal memory in @entity3 and @entity2 . This suggests a possible beneficial role of certain antidepressants on @entity1 , which may have clinical implications and provide insight into underlying pathophysiology. However, the current findings should be replicated in independent samples.

title: Serum level of XXXX is associated with better memory in psychotic disorders.

answer: @entity6


abstract: Advanced glycation end products (AGEs) are a contributing factor in the @entity9 that is characteristic of proliferative @entity1 . However, a previous study made a promising observation that domain I  -IV of b2  -glycoprotein  I (DI  -IV) inhibits @entity9 in @entity0 umbilical vein cells. The present study aimed to confirm the inhibition of AGE  -induced @entity9 in retinal endothelial cells by DI  -IV and to investigate the potential underlying mechanisms. The RF/6A @entity6 choroid  -retinal vascular endothelial cell line was cultured in  vitro and treated with AGEs in the presence or absence of different concentrations of DI  -IV. The proliferation, migration and tube formation of the RF/6A cells were evaluated using MTS assays, in  vitro wound healing assays and in  vitro Matrigel @entity9 assays, respectively. The mRNA expression of @entity2 ( @entity2 ), @entity3 ( @entity3 )  2, @entity3  1 and receptor for AGE ( @entity7 ) were quantified by reverse transcription quantitative polymerase chain reaction. The expression of @entity8 , @entity3 and the activation of protein kinase B ( @entity4 ) and extracellular signal  -regulated kinase (ERK) were also assessed by western blot analysis. The results indicated that AGEs promoted the migration, proliferation and tube formation of RF/6A cells in  vitro  (P<0.05), increased the expression of @entity2 , @entity3 and @entity7  (P<0.05) and increased the phosphorylation of @entity4 and ERK (P<0.05). DI  -IV inhibited the increase in @entity3 mRNA and protein, but did not inhibit the increase in @entity2 or @entity7 mRNAs. These results led to the conclusion that DI  -IV inhibited AGE  -induced @entity9 in the RF/6A cells, which was accompanied by a downregulation in the expression of @entity3 and its downstream phosphatidylinosol 3  -kinase/ @entity4 and mitogen  -activated protein kinase/ @entity5  pathways. These findings provide further support towards the treatment of proliferative @entity1 by interventions that act via a mechanism similar to that of DI  -IV.

title: Domain I-IV of b2-glycoprotein  I inhibits advanced glycation end product-induced XXXX by down-regulating @entity2  2 signaling.

answer: @entity9


abstract: BACKGROUND: The optimal treatment for resected @entity2 is controversial because direct comparisons of adjuvant chemotherapy (CT) alone and chemotherapy and radiotherapy (CRT) are limited. This study assessed outcomes of CT versus CRT in a national cohort to provide a modern estimate of comparative effectiveness. METHODS: @entity0 with @entity5 -3N0-1M0 @entity2 after pancreatectomy were identified in the National @entity1 Data Base. @entity3 ( @entity3 ) was compared for CT and CRT groups with Cox regression and propensity score matching. Subset analyses by clinicopathologic characteristics were performed. RESULTS: This study identified 6165 @entity0 treated with CT (n   =   2334 or 38%) or CRT (n   =   3831 or 62%). Most were classified as @entity4 (72%), @entity6 (67%), and status-post R0 resection (84%). For CRT @entity0 , the median radiotherapy dose was 50.4 Gy. Compared with CT, CRT was associated with improved @entity3 in a univariate analysis (median, 20.0 vs 22.3 months; at 5 years, 16.5% vs 19.6%; P   <   .001) and a multivariate analysis (hazard ratio [HR], 0.893; 95% confidence interval [CI], 0.837-0.953; P   =   .001). CRT remained associated with improved @entity3 after propensity score matching (HR, 0.851; 95% CI, 0.793-0.913; P   <   .001). Subset analyses showed that CRT was associated with improved @entity3 among @entity0 with @entity4 (HR, 0.892; 95% CI, 0.828-0.962; P   =   .003) or @entity6 disease (HR, 0.856; 95% CI, 0.793-0.924; P   <   .001) and both R0 resection (HR, 0.901; 95% CI, 0.839-0.969; P   =   .005) and R1 resection (HR, 0.842; 95% CI, 0.722-0.983; P   =   .030). CONCLUSIONS: CRT was independently associated with improved @entity3 after the resection of @entity2 in a large national cohort and particularly among @entity0 with R1 resection and @entity6 disease. Well-designed randomized comparisons of CRT and CT are urgently needed. @entity1 2015;121:4141-4149.    2015 American @entity1 Society.

title: Addition of radiotherapy to adjuvant chemotherapy is associated with improved overall survival in resected @entity2 : An analysis of the National XXXX Data Base.

answer: @entity1


abstract: BACKGROUND: Application of @entity8 ( @entity8 ) to treat @entity0 suffering from @entity1 (GDOO) is today considered a well-recognized palliative treatment. Use of @entity8 has emerged as an attractive alternative to surgical treatment of such @entity0 . PURPOSE: To report the immediate and the mid-term clinical outcomes from a series of consecutive @entity0 treated with exclusively fluoroscopic-guided insertion of @entity8 . MATERIAL AND METHODS: This was a retrospective study including @entity0 suffering from GDOO that were either ineligible for or unwilling to undergo surgery. @entity0 with potentially curable disease, uncorrectable @entity6 , @entity5 , @entity4 , presence of @entity9 , and @entity2 were excluded. Technical success, clinical success, and major complications were calculated. In addition, stent migration, stent re-obstruction, restenosis, and overall re-interventions due to recurrent symptoms were considered. Kaplan-Meier survival analysis was used for @entity0 survival estimation while both bivariable and multivariable analysis were performed to identify any independent predictors of outcomes. RESULTS: Fifty-one @entity0 , (mean age, 63.73        15.62 years) met the study's criteria and were included in the final analysis. Technical and clinical success were 90.19% (n   =   46/51) and 91.30% (n   =   42/46), respectively. Major complications rate was 3.92%. Stent migration was noted in four cases. @entity3 and re-obstruction rates were 19.57% and 10.87%, respectively. No cases of peri-procedural mortality were noted, while Kaplan-Meier estimates for 1- and 2-year survival were 16.8% and 7.2%, respectively. Clinically successful cases and @entity0 with primary @entity1 were related with more favorable survival compared to unsuccessful and @entity0 suffering from GDOO due to extrinsic compression by neoplastic or @entity7 . CONCLUSION: Exclusively fluoroscopically inserted @entity8 for GDOO is safe and highly effective method for palliative treatment.

title: Fluoroscopic-guided insertion of XXXX for @entity1 : immediate results and clinical outcomes.

answer: @entity8


abstract: OBJECTIVE: To estimate the cost-effectiveness of three @entity8 ( @entity10 , @entity9 , and @entity4 ) and generic @entity6 in the treatment of nonneutropenic adult @entity0 with @entity7 and/or @entity1 in intensive care units in Spain. MATERIALS AND METHODS: A decision-tree model was applied. The success and safety (hepatic and renal adverse effects) of first-line treatments were obtained from meta-analyses and systematic reviews of clinical trials. In the case of failure, a second-line treatment (liposomal @entity5 after the @entity8 , or one of the @entity8 after @entity6 ) was administered. The duration of the treatments (14 days total) was established by a panel of clinical experts using the Delphi method and according to @entity3 Society of America guidelines. The cost of the medications and renal @entity2 were considered. Deterministic and probabilistic sensitivity analysis using Monte Carlo simulations were carried out. RESULTS: The total cost of the treatment of @entity7 and/or @entity1 with @entity10 , @entity9 , @entity4 , and @entity6 was    5,483,    5,968,    6,231, and    2,088, respectively. @entity10 was the dominant treatment (more effective, less expensive) compared to @entity4 and @entity9 . The cost of achieving one more @entity0 successfully treated with @entity10 , @entity9 , and @entity4 compared to @entity6 was    17,199,    23,962, and    27,339, respectively. The result remained stable, despite modification of the duration of the first-line and second-line treatments, as well as most of the dosing regimens. The probabilistic analysis also remained stable. CONCLUSION: In accordance with this economic study, @entity10 would produce savings and would be the dominant treatment compared with @entity4 and @entity9 in nonneutropenic adult @entity0 with @entity7 and/or @entity1 in intensive care units in Spain.

title: Cost-effectiveness of three @entity8 and @entity6 in the treatment of XXXX and/or @entity1 in nonneutropenic adult @entity0 .

answer: @entity7


abstract: BACKGROUND: In preschool @entity0 , no study assessed the relation between wheezing and @entity2 severity. Our aims were to estimate the prevalence of current wheezing (CW) in preschoolers and to study the association between CW and current @entity2 (CR), considering its severity/persistency. METHODS: This is a cross-sectional, nationwide, population-based study including a representative sample of 5003 Portuguese @entity0 aged 3-5 years. Data were collected by a face-to-face interview with caregivers using an adapted ISAAC questionnaire. CW was defined as presence of >= 1 wheezing episode in the previous 12 months. @entity2 severity/persistency was classified according to @entity1 and its Impact on Asthma. RESULTS: Current wheezing prevalence was 24.5% [95% CI 23.3-25.7]; 9.4% of the @entity0 had >= 4 wheezing episodes in the previous year. @entity0 with CR had an odds ratio (OR) of 4.0 [95% CI 3.4-4.5] for CW; it was highest for @entity0 with moderate-severe persistent @entity2 (11.5 [95% CI 8.1-16.3]), even after adjusting for possible confounders. Wheezers with CR reported more wheezing treatment use (p = 0.024) than those without CR. There was a trend for a higher number of wheezing episodes with more persistent and severe nasal disease - 48.4% of @entity0 with moderate-severe persistent @entity2 had >4 wheezing episodes vs. 28.9% in moderate-severe intermittent, 20.0% in mild persistent, 10.8% in mild intermittent, and 3.6% in those without CR; p < 0.001. CONCLUSIONS: Current wheezing was present in almost 25% of preschool @entity0 and was strongly associated with @entity2 , especially moderate-severe persistent disease. Preschoolers with both CW and @entity2 seem to have a more severe phenotype, emphasizing the need for concurrent evaluation of nasal and bronchial symptoms even in small @entity0 .

title: Severity of XXXX and wheezing is strongly associated in preschoolers: A population-based study.

answer: @entity2


abstract: UNASSIGNED: High affinity @entity4 receptor (HFR) can be overexpressed in @entity0 and is associated with poor prognosis, however the expression in @entity0 ( @entity0 ) is unknown. The aim of this study was to analyze the rate of HFR expression in @entity0 and its role in the prognosis of this high-risk cohort. We analyzed 19 brain @entity2 (BM) and 13 @entity3 ( @entity3 ) from a total of 25 @entity1 . HFR status was assessed by immunohistochemistry. Median follow-up was 4.2 years (range 0.6-18.5). HFR was positive in 4/19 BM (21.1%) and in 1/13 @entity3 (7.7%). Positive samples had low H-scores (range 1-50). 56% of @entity1 had apocrine differentiation. @entity5 was similar between @entity1 with positive HFR (median @entity5 48 months) and negative HFR (median @entity5 69 months) (P = 0.25); and between @entity1 with apocrine differentiation (median @entity5 63 months) and those without apocrine differentiation (median @entity5 69 months) (P = 0.49). To the best of our knowledge, this is the first analysis of HFR expression in @entity0 . While previous studies associated the presence of HFR with worse prognosis; in our cohort HFR was positive in only 21.1% of BM with low levels of positivity. Neither HFR nor apocrine features had impact in @entity5 .

title: Expression of high affinity @entity4 receptor in @entity0 brain XXXX .

answer: @entity2


abstract: Of 1300 @entity1 @entity0 76 (5.8%) were found to have @entity7 ( @entity7 ). These 76 @entity0 were examined at the @entity1 outpatient clinic of Bakirk  y State Hospital for Neurological and Psychiatric Diseases between 1991 and 1996 and data obtained were analysed retrospectively. Clinically typical @entity6 were reported in 40.8%, @entity5 in 100%, and generalized @entity3 in 82.9% of the @entity0 . Neurological and mental examination was normal for all @entity0 with the exception of three cases; two with essential @entity2 and one with minimal @entity8 . Precipitating factors were noted in 85.5% of cases. Abnormal EEG was recorded in 73 (6.1%) @entity0 . Abnormalities mainly consisted of generalized discharges of spike/polyspike and slow-wave (86.6%) and generalized paroxysmal theta or delta (9.2%). Fifteen (19.7%) had focal abnormalities and 20 (26.4%) had @entity9 discharges. Of the 76 @entity0 , 40 (52.6%) were not diagnosed at the initial interview; definite diagnosis was delayed by a mean of 5.9 years. As a result of misdiagnosis at the initial interview 40 @entity0 had been administered AED except for @entity4 . After reassessment of clinical and EEG findings, the medication was changed to valproate therapy. As a result, 65 of our @entity7 @entity0 (85.5%) were @entity3 free after a one-year follow-up period.

title: Misdiagnosis and treatment in XXXX .

answer: @entity7


abstract: UNASSIGNED: 4596 Background: Controversy exists regarding the optimal management of @entity1 . This analysis defines the Kaiser experience over a 20-year period. Options after orchiectomy were observation vs. adjuvant radiation or chemotherapy. METHODS: This is a retrospective study of 502 @entity0 diagnosed with @entity1 from 1990-2010. All @entity0 underwent orchiectomy. Outcomes examined were @entity6 ( @entity6 ), @entity4 ( @entity4 ), and @entity4 ( @entity4 ). RESULTS: Of the 502 @entity0 , 329 were treated with @entity2 (113 to a pelvic/paraaortic field, 202 to a paraaortic field, and 14 to other fields), 79 had chemotherapy (33 had @entity5 x 1, 36 had carboplatin x 2, and 10 had other agents), and 94 were observed. Among the @entity2 @entity0 (median follow-up 7.5 y), there were 8 relapses and 12 @entity3 , of which 2 were @entity3 from @entity7 . @entity6 was 97.6% and 97.2% at 2 and 5 years. Median time to relapse was 13.1 mos. Of the @entity0 who relapsed, 6 were successfully salvaged with chemotherapy; 2 died of disease. @entity4 was 99.6% and 98.0% and @entity4 was 99.6% and 99.3% at 2 and 5 years. @entity3 from disease occurred at a median of 22.4 mos. Among the chemotherapy @entity0 (median follow-up 2.6 y), there was 1 relapse at 14 mos and no @entity3 . Two-year @entity6 was 98.3% and @entity4 and @entity4 were 100%. The @entity0 who relapsed was successfully salvaged with @entity8 . Among the observation @entity0 (median follow-up 5.2 y), there were 11 relapses, 3 @entity3 , and no @entity3 from @entity7 . @entity6 was 89.2%, @entity4 was 98.8%, and @entity4 was 100% at 2 and 5 years. Median time to relapse was 11.5 mos. Of the @entity0 who relapsed, 6 were salvaged with @entity2 and 4 with chemotherapy; all were NED at last follow-up. One @entity0 is currently undergoing chemotherapy. @entity6 , @entity4 , and @entity4 were compared via the log-rank test. There was no difference in @entity4 or @entity4 among the groups. @entity6 was lower among observation @entity0 (p < 0.001). CONCLUSIONS: Consistent with published trials, our data show that adjuvant radiation and chemotherapy yield similar outcomes in the management of @entity1 . Observation is a viable option that allows @entity0 to avoid the toxicities of therapy. Our data confirm that while observation results in a lower @entity6 , @entity0 who relapse can be salvaged, and @entity4 and @entity4 are not affected.

title: Observation versus adjuvant radiation or chemotherapy in the management of XXXX .

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) associated with @entity3 ( @entity3 ) can be severe and is well known to reduce mobility early in the disease. However the burden of @entity2 is unknown and overlooked. We studied the frequency of @entity2 and their impact on quality of life. METHODS: A cross-sectional study of 60 @entity0 who had @entity4 -IgG positive @entity3 associated @entity6 was performed using the Bladder Control Scale, Lower Urinary Tract Quality of Life, Bowel Control Scale and Neurogenic Bowel Score, Short-Form-36 Health Survey and EDSS. The relationships between the variables were analysed with multiple linear regression. RESULTS: Fifty @entity0 and 10 @entity0 participated. 78% (47/60) @entity0 reported @entity2 and a similar number reported bowel problems. 87% (52/60) @entity0 reported either @entity2 . 65% (39/60) developed residual symptoms after the first episode of @entity5 and the remaining by the second episode. Both @entity2 reduced quality of life and required modification of lifestyle in 83% (39/47) and 70% (33/47) respectively. CONCLUSION: Bladder and @entity1 is very common in @entity3 associated @entity5 developing early in the disease and significantly affects quality of life.

title: Bladder and @entity1 affect quality of life. A cross sectional study of 60 @entity0 with XXXX antibody positive @entity3 .

answer: @entity4


abstract: The effect of @entity0 on root growth, secondary-root formation and root gravitropism in seedlings of @entity1 was investigated by using @entity2 -treated seedlings and a viviparous mutant, both of which lack carotenoids and @entity0 . Primary roots of seedlings grown in the presence of @entity2 grew significantly slower than those of control (i.e. untreated) roots. Elongation of @entity2 -treated roots was inhibited significantly by the exogenous application of 1 mM @entity0 . Exogenous application of 1 micromole and 1 nmole @entity0 had either no effect or only a slight stimulatory effect on root elongation, depending on the method of application. The absence of @entity0 in @entity2 -treated plants was not an important factor in secondary-root formation in seedlings less than 9-10 d old. However, @entity0 may suppress secondary-root formation in older seedlings, since 11-d-old control seedlings had significantly fewer secondary roots than @entity2 -treated seedlings. Roots of @entity2 -treated and control seedlings were graviresponsive. Similar data were obtained for vp-9 mutants of @entity1 , which are phenotypically identical to @entity2 -treated seedlings. These results indicate that @entity0 is necessary for neither secondary-root formation nor for positive gravitropism by primary roots.

title: Root growth, secondary root formation and root gravitropism in carotenoid-deficient seedlings of XXXX .

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Ankle-brachial index (ABI) is currently recommended for the screening of @entity3 . However, this method becomes less reliable in the presence of calcified, incompressible arteries, as they result in an erroneously elevated ABI, and an additional measure termed the @entity4 ( @entity4 ) is recommended. The evaluation of ABI, and in particular @entity4 , typically requires significant technical skill and often involves referral to a vascular laboratory. This present situation reveals the need for a valid and reliable, automatic, noninvasive device that will provide both ABI and @entity4 at the level of the primary care physician. The aim of this study was to evaluate the accuracy and reliability of such a device, the Vasera VS-1500AT, in the assessment of toe, ankle, and @entity2 . MATERIALS AND METHODS: This study involved the assessment of 80 limbs from 40 normotensive and @entity1 individuals (17 @entity0 and 23 @entity0 ) with a mean age of 45    18 years. RESULTS: There was a statistically significant correlation (r=0.92) between toe systolic blood pressures obtained manually with photoplethysmography compared with those obtained through the automated device. The same significant correlation was also seen between the two with ankle (r=0.87) and @entity2 . CONCLUSION: These strong correlations demonstrate that further investigation of this device is warranted regarding its use as a screening tool for the assessment of @entity3 . The automation provided by this device could potentially eliminate variability in these measurements thereby allowing for screening and diagnosis to be done without referral to a vascular laboratory.

title: Preliminary assessment of an automatic screening device for XXXX using ankle-brachial and toe-brachial indices.

answer: @entity3


abstract: BACKGROUND: In recent years, many surgeons dealing with endocrine surgery have increasingly performed total thyroidectomy for @entity3 . However, total excision of the thyroid in the treatment of benign lesions has been surrounded by even more controversy than its role in @entity1 treatment. The complication rate appears to be higher when the operation is done by inexperienced surgeons who have no special skills in endocrine surgery using proper techniques. The aim of this study is to determine whether surgeons experience and the refinement of surgical techniques are associated with postoperative recurrent @entity4 or @entity5 after total thyroidectomy for @entity3 . METHODS: A total of 68 consecutive @entity0 who underwent total thyroidectomy for @entity3 were reviewed. Twenty-six of these were from between January 1998 and June 1999 (first period) and 42 from between June 1999 and September 2000 (second period). @entity0 were divided into two subgroups according to different periods and different surgical techniques to identify the RLNs and the parathyroid glands. RLNs function was evaluated pre- and postoperatively by an otolaryngologist, and serum @entity2 levels were measured at the postoperative follow-up. RESULTS: During the first period of the study, transient hypocalcaemia was determined in 8 (31%) @entity0 . Hypocalcaemia was clinically symptomatic in 5 (19%) @entity0 . Transient @entity6 palsy developed in 4 (15%) @entity0 . Unilateral permanent @entity6 palsy due to operative injury was observed in 1 (4%) @entity0 . During the second period, we noted transient @entity5 in 11 (26%) @entity0 and symptomatic @entity5 in 6 (4%) patients. Serum @entity2 levels returned to normal within 4 weeks after operation in all @entity0 . Neither transient nor permanent @entity6 palsy was observed during this period. CONCLUSIONS: Complications of total thyroidectomy can be minimized with increasing experience and the refinement of surgical technique.

title: Influence of the refinement of surgical technique and surgeon's experience on the rate of complications after total thyroidectomy for XXXX .

answer: @entity3


abstract: OBJECTIVE: To evaluate the demographics and characteristics of @entity0 with @entity5 ( @entity5 ). MATERIAL AND METHODS: In this retrospective study, we analyzed the medical records of all @entity0 who were treated for @entity5 in the department of pediatric surgery of Tepecik Training and Research Hospital over a period of 10 years (1995-2004). Age, gender, clinical manifestations, diagnostic approaches, and histopathological reports were documented. RESULTS: In total, 57 @entity0 were diagnosed with @entity5 . Of these, 40 @entity0 were treated surgically. Furthermore, 26 had acute abdomen, 15 had @entity3 , 10 had @entity1 , and 6 had some other diagnosis. The mean age of the @entity0 (n=43) was 4.77  3.82 years, whereas that of the @entity0 (n=14) was 3.85  3.67 years. Histopathological examination revealed ectopic mucosa in 9 @entity0 , omphalomesenteric duct remnants in 4 @entity0 , @entity4 in 24 @entity0 , and @entity2 in 14 @entity0 . CONCLUSION: The prevalence of @entity5 was 1.6%. @entity0 were approximately 3 times more commonly affected than @entity0 . In most cases, the initial diagnosis was acute abdomen and the presenting symptoms on admission were @entity3 and @entity1 .

title: XXXX : Ten years' experience.

answer: @entity5


abstract: Pulse pressure has been recognized as a marker of @entity1 in normotensives. Moreover, internal carotid artery @entity2 ( @entity2 ) has been proposed to reflect @entity4 . The aim of the present study was to evaluate the predictive value of other parameters derived from ambulatory blood pressure monitoring (ABPM), myocardial ultrasound, and carotid ultrasound to predict the location and the severity of @entity4 in normotensives. One hundred and thirteen @entity0 with suspected @entity4 underwent coronary angiography, 24-h ABPM and myocardial/carotid ultrasound. Multivariate analysis was applied and equations were extrapolated based on independent variables derived from ABPM and ultrasound. The Gensini score was independently correlated with male gender, pulse pressure, average heart rate for both 24-h (p=0.001) and night (p=0.006) values, as well as percentage of high systolic blood pressure (BP), average diastolic BP, average mean BP, and heart rate concerning daily mesurements (p=0.001). Moreover, the Gensini score was independently correlated with end-systolic volume, posterior wall thickness during systole and intraventricular septum thickness during diastole, along with male gender and age (p=0.001), as well as mean internal and right common carotid artery @entity2 (p=0.002). Similar mathematical formulas have been calculated separately for the coronary arteries and their main branches. In conclusion, the location and the severity of @entity3 can be effectively evaluated by ABPM and myocardial/carotid ultrasound in normotensives. This approach could be useful for determining atypical @entity0 at risk and/or for treating @entity0 with suspected @entity3 who refuse coronary angiography.

title: Ability of ambulatory blood pressure monitoring and myocardial/carotid ultrasound to predict the location and the severity of @entity4 in normotensive XXXX : a clinical study.

answer: @entity0


abstract: BACKGROUND: Collagenase clostridium histolyticum (CCH) injection for @entity2 was approved in the USA in 2010. Current FDA guidelines stipulate that finger manipulation occurs the day following injection. To investigate the safety and efficacy of delaying manipulation to 2 or 4  days following CCH injection, we conducted a prospective, randomized trial at two sites. METHODS: @entity0 with @entity2 involving the metacarpophalangeal (MCP) joint >= 20   caused by a palpable cord participated. All @entity0 received one dose of CCH (0.58  mg/0.25  ml) and were followed for 90  days. The primary end point was the percent of @entity0 maintaining clinical success (reduction of contracture to 0  -5  ) at 90  days post-injection. Adverse events and change in Michigan Hand Questionnaire (MHQ) score were recorded as secondary end points. RESULTS: Thirty-seven @entity0 enrolled; 13 were manipulated on day 1, 11 on day 2, and 13 on day 4. At 30  days after injection, the percentage of @entity0 obtaining reduction of contracture to <0  -5   extension was 92, 82, and 85  % in groups 1, 2, and 3, respectively, with no significant difference. At 90  days follow-up, the percentage of @entity0 maintaining 0  -5   extension was 91, 82, and 83  % in groups 1, 2, and 3, respectively, with no significant difference. Adverse events were comparable to rates in prior studies. There were no serious adverse events. There was no statistical difference in MHQ scores between groups at any time point. CONCLUSIONS: Delaying manipulation to day 2 or 4 following CCH injection for @entity1 does not increase adverse events or result in loss of efficacy. LEVEL OF EVIDENCE: Therapeutic, Level II.

title: Delayed manipulation after collagenase clostridium histolyticum injection for XXXX .

answer: @entity2


abstract: BACKGROUND: @entity0 evaluation of @entity2 severity and medication needs is mostly based on respiratory symptoms and may be influenced by changes in perception of bronchoconstriction-induced sensations. However, the influence of @entity2 medication on the ability to perceive symptoms is still to be documented. This study evaluated the effects of short-term and regular use of @entity6 on the perception of @entity3 -induced bronchoconstriction (MIB) in subjects with mild @entity2 , using inhaled @entity5 on an "as required" basis (n=15), and in subjects with moderate @entity2 , using daily inhaled @entity4 (mean daily dose, 640 microg; n=15) in addition to @entity5 to control their @entity2 . METHODS: @entity3 challenges (MC) were performed at entry into the study, and then before, 1, and 12 h following inhalation of 50 microg of @entity6 or a placebo, after a 15-day baseline period; and after 4 weeks of twice daily use of those treatments. The measurements were then repeated with the alternate treatment after a 15-day washout period. Finally, a last MC was performed after another 15-day washout period. For each MC, the perception score of bronchoconstriction-associated breathlessness at 20% fall in FEV1 ( @entity7 ) was evaluated on a modified Borg scale from 0 to 10. RESULTS: Subjects using regular @entity4 had a higher baseline @entity7 than those using only @entity5 (means: 3.06 0.06 and 2.01+/-0.07, p=0.0001). Short- and long-term use of @entity6 did not change significantly the @entity7 compared with placebo (p>0.05) in either group (with or without @entity1 ). Although there were some intraindividual variations, mean @entity7 did not vary significantly throughout the study. CONCLUSION: These observations show that the perception of bronchoconstriction-associated breathlessness is not influenced by regular use of @entity6 . @entity0 using inhaled corticosteroids show a greater perception of MIB.

title: Influence of XXXX and @entity6 on the perception of @entity3 -induced bronchoconstriction.

answer: @entity4


abstract: Recently, there has been strong interest in the development of imaging techniques to quantify axonal and myelin pathology in @entity0 with @entity1 ( @entity1 ). @entity7 , a condition characterised by inflammatory demyelination of the optic nerve, is one of the commonest sites of @entity1 relapse, and exhibits similar pathological alterations to @entity1 lesions elsewhere in the central nervous system (CNS). Unlike other regions of the CNS, however, the function of the optic nerve can be accurately assessed using clinical measures, as well as electrophysiological techniques such as visual evoked potential recordings. Therefore, @entity7 is useful for investigating the relationship between abnormalities in optic nerve structure, assessed using magnetic resonance imaging (MRI), and @entity4 , assessed clinically and electrophysiologically. The aims of the present study were to assess optic nerve @entity6 in @entity0 with a history of unilateral @entity7 using MRI, and then to identify correlations between @entity2 . Ten controls and sixteen @entity0 underwent high resolution optic nerve diffusion tensor imaging (DTI), T2- and T1-weighted MRI. In addition, Snellen visual acuity and the latency and amplitude of multifocal visual evoked potentials (mfVEP) were tested in all @entity0 . Diffusion and volumetric MRI indices were correlated to mfVEP functional indices. Significant abnormalities were detected in MRI and mfVEP measures in @entity0 ' affected nerves compared to unaffected optic nerves or optic nerves from healthy controls. Reduced mfVEP amplitude in the affected side significantly correlated with both affected @entity5 (R=0.58, p=0.02) and reduced fractional anisotropy (FA) (R=0.52, p=0.04). However, @entity3 and reduced FA did not correlate with each other. To further investigate this disassociation, we used linear regression analysis with @entity5 and optic nerve FA as independent variables and mfVEP amplitude as the dependent variable. The resulting linear regression model was highly significant (R=0.819, p=0.001). These results show that, 4 years after unilateral @entity7 , MRI-based measures of optic nerve @entity6 (decreased anisotropy and volume) independently predict @entity4 .

title: Optic nerve diffusion changes and @entity3 jointly predict @entity4 after XXXX .

answer: @entity7


abstract: @entity2 is caused by the unicellular apicomplexan parasites of the genus @entity4 , some of which, including the major @entity0 parasite @entity4 , have extreme genome compositions (A/T content > 80%). In this overview of RNA production, roles and degradation, we show that despite their unusual genome composition these parasites generally exhibit the standard eukaryotic features of these processes. Thus genes are monocistronic and transcribed by RNA polymerases that conform to the general categories of I, II, and III. @entity4 spp. are unusual in that they possess structurally distinct rRNA genes that are expressed at different points in the complicated life cycle of the parasite. @entity1 follows a cascade consistent with a dependency upon plant-like apetala 2 (AP2) DNA-binding proteins. mRNA is transported to, translated and degraded in the cytoplasm and the transcription pattern is largely inflexible and responsive to temperature and @entity3 but not drugs. Furthermore, although @entity4 spp. undertake controlled repression of mRNA species at a number of points in their life cycle only one mechanism, employed by female gametocytes (gamete precursor cells), is clear; it resembles that of metazoan female gametes, consisting of a complex of repression-associated proteins in an architecture formed with the mRNA 5' cap and dependent on U-rich untranslated region (UTR) elements. Extensive antisense transcription has been documented resulting in the production of both short and long transcripts of generally unknown functional significance. This review attempts to summarize what is currently known about the biology of @entity4 RNA.

title: From cradle to grave: RNA biology in XXXX parasites.

answer: @entity2


abstract: OBJECTIVE: This study examines relationships between multiple aspects of the home food environment and @entity1 -promoting characteristics of 12- to 13-year-old adolescents' diets, specifically frequency of consumption of high-energy fluids, sweet snacks, savory snacks, and take-out foods. RESEARCH METHODS: This was a cross-sectional study including 347 adolescents 12 to 13 years of age and their parents. Data were collected via self-completed surveys. The adolescents' diets were assessed using a Food Frequency Questionnaire derived from existing age-appropriate National Nutrition Survey data. An extensive range of domains within the home food environment were assessed. Bivariate linear regression analyses were run split by gender. Forced entry multiple linear regression analyses (adjusting for all variables significant in bivariate analyses as well as for maternal education) were also performed, stratified by the sex of the @entity0 . RESULTS: The influence of mothers, either as models for eating behaviors or as the providers of food, was pervasive. Mothers' intake of high-energy fluids (p = 0.003), sweet snacks (p = 0.010), savory snacks (p = 0.008), and take-out food (p = 0.007) was positively associated with @entity0 ' intake of all these foods. In addition, mothers' intake of high-energy fluids was positively associated with daughters' consumption of these drinks (p = 0.025). Furthermore, availability of unhealthy foods at home was positively associated with @entity0 ' sweet snack (p = 0.001), @entity0 ' savory snack (p < 0.001), @entity0 ' savory snack (p = 0.002), and, in the bivariate analyses, @entity0 ' high-energy fluid consumption (p = 0.002). DISCUSSION: This study of home food environment influences on adolescent diet highlights the pervasive influence of mothers in determining adolescents' @entity1 -promoting eating, providing direction for @entity1 prevention strategies and future research.

title: Associations between the home food environment and XXXX -promoting eating behaviors in adolescence.

answer: @entity1


abstract: The experience of surgical treatment of 34 @entity0 , suffering the heart valves affection in @entity2 ( @entity2 ), was summarized. In 29 @entity0 the affection of a mitral valve (MV) was noted and in 5--of a tricuspid one. Functional disorders of valves was observed in presence of a large, moving, frequently calcified @entity2 owing high density. Radical reconstructive-restoration interventions were performed with artificial blood circulation. In 9 @entity0 the MV prosthesis was performed, in 3--the @entity1 excision, affecting undervalvular apparatus and in 4--the MV plasty (annuloplication). The MV cuspids deformity was corrected in 8 @entity0 and for the MV chords rupture in 1 @entity0 the plasty was performed, using sectored resection. The MV cuspids implantation was done in 9 @entity0 . Late follow-up results were studied up in 26 @entity0 in terms from 2 mo to 20 years postoperatively. Good result was achieved in 18 @entity0 , fair--in 5 and unsatisfactory--in 3. Thus, the presence of @entity2 may be accompanied by necessity to correct the coexistent valve affection, what improves the operation result.

title: [ XXXX and its correction in the @entity2 ].

answer: @entity2


abstract: Soluble @entity0 binding proteins (FABPs) are thought to facilitate exchange of @entity1 between intracellular membranes. Although many FABP variants have been described, they fall into two general classes. "Membrane-active" FABPs exchange @entity1 with membranes during transient collisions with the membrane surface, whereas "membrane-inactive" FABPs do not. We used modeling of @entity0 transport between two planar membranes to examine the hypothesis that these two classes catalyze different steps in intracellular @entity0 transport. In the absence of FABP, the steady-state flux of @entity0 from the donor to the acceptor membrane depends on membrane separation distance (d) approaching a maximum value (J(max)) as d approaches zero. J(max) is one-half the rate of dissociation of @entity0 from the donor membrane, indicating that newly dissociated @entity0 has a 50% chance of successfully reaching the acceptor membrane before rebinding to the donor membrane. For larger membrane separations, successful transfer becomes less likely as diffusional concentration gradients develop. The mean diffusional excursion of the @entity0 into the water phase (d(m)) defines this transition. For d<d(m), dissociation from the membrane is rate limiting, whereas for d>d(m), aqueous diffusion is rate limiting. All forms of FABP increase d(m) by reducing the rate of rebinding to the donor membrane, thus maintaining J(max) over larger membrane separations. Membrane-active FABPs further increase J(max) by catalyzing the rate of dissociation of @entity1 from the donor membrane, although frequent membrane interactions would be expected to reduce their diffusional mobility through a membrane-rich cytoplasm. Individual FABPs may have evolved to match the membrane separations and densities found in specific cell lines.

title: Transfer of XXXX between intracellular membranes: roles of soluble binding proteins, distance, and time.

answer: @entity1


abstract: PURPOSE: To determine outcome measures for a clinical trial of @entity5 ( @entity5 ) associated with mutations in the @entity6 gene. DESIGN: Retrospective observational case series. METHODS: 28 @entity0 with @entity6 - @entity5 (ages 2-59) were studied clinically and with chromatic full-field sensitivity testing (FST), optical coherence tomography (OCT), pupillometry, and the NEI Visual Function Questionnaire. RESULTS: FST permitted quantitation of cone and rod sensitivity in these @entity0 with severe @entity1 . For most @entity0 , the degree of rod and cone sensitivity losses showed a relationship, thereby providing an opportunity to divide @entity0 into cohorts by severity of @entity4 . OCT analyses indicated that retinal structure could be used not only as an objective safety measure but also as an exploratory efficacy outcome. A foveal bulge was not present in 67% of @entity0 . The intensity of IS/ @entity3 (EZ line) reflectivity was reduced significantly at the fovea and in the rod-dense superior retina. Based on OCT and FST parameters, most @entity0 had dissociation of structure and function. Abnormal pupillometry sensitivity in the majority of @entity6 - @entity5 @entity0 provided another objective efficacy outcome. NEI VFQ scores showed a similar range of findings to those of other severe @entity2 . CONCLUSION: Conventional outcome measures, such as visual acuity and the NEI VFQ, will need to be complemented by methods more specific to this @entity6 - @entity5 population. Any therapeutic strategy should determine if there is an effect on rod as well as cone function and structure. FST provides a photoreceptor-based subjective outcome; and OCT in two retinal regions, fovea and superior retina, can assess photoreceptor structure. A change in the relationship of structure and function away from baseline becomes evidence of efficacy.

title: Defining Outcomes for Clinical Trials of @entity5 caused by XXXX Mutations.

answer: @entity6


abstract: AIM: To assess the prospective association between objectively measured physical activity and kidney function over 4  years in @entity0 with @entity2  2 @entity1 . METHODS: Individuals (120 @entity0 and 206 @entity0 ) participating in the ADDITION-Plus trial underwent assessment of sedentary time (SED-time), time spent in moderate-to-vigorous-intensity physical activity (MVPA) and total physical activity energy expenditure (PAEE) using a combined heart rate and movement sensor, and kidney function [estimated glomerular filtration rate (eGFR), serum @entity3 and urine albumin-to- @entity3 ratio (ACR)] at baseline and after 4  years of follow-up. Multivariate regression was used to quantify the association between change in SED-time, MVPA and PAEE and kidney measures at four-year follow-up, adjusting for change in current smoking status, waist circumference, HbA1c , systolic blood pressure, @entity4 and medication usage. RESULTS: Over 4  years, there was a decline in eGFR values from 87.3 to 81.7  ml/min/1.73m(2) (P  <  0.001); the prevalence of reduced eGFR (eGFR  <  60  ml/min/1.73m(2) ) increased from 6.1 to 13.2% (P  <  0.001). There were small increases in serum @entity3 (median: 81-84   mol/l, P  <  0.001) and urine ACR (median: 0.9-1.0  mg/mmol, P  =  0.005). Increases in SED-time were associated with increases in serum @entity3 after adjustment for MVPA and cardiovascular risk factors (b  =  0.013, 95%  CI: 0.001, 0.03). Conversely, increases in PAEE were associated with reductions in serum @entity3 (b  =  -0.001, 95%  CI: -0.003, -0.0001). CONCLUSION: Reducing time spent sedentary and increasing overall physical activity may offer intervention opportunities to improve kidney function among individuals with @entity1 . (Trial Registry no. ISRCTN  99175498).

title: Objectively measured sedentary time, physical activity and kidney function in @entity0 with recently diagnosed @entity2  2 XXXX : a prospective cohort analysis.

answer: @entity1


abstract: UNASSIGNED: Development of novel imaging probes for @entity0 diagnostics remains critical for early detection of disease, yet most imaging agents are hindered by high off-target accumulation (e.g. liver, spleen) and suboptimal @entity0 accumulation. To overcome these limitations, researchers have adapted antibodies for imaging purposes. As @entity0 express atypical patterns of cell surface proteins in comparison to non-cancerous tissues, novel antibody-based imaging agents can be constructed to target individual @entity0 cells or surrounding vasculature. Using molecular imaging techniques, these agents may be utilized for detection of @entity0 and monitoring of therapeutic response. Currently, there are several imaging modalities commonly employed for molecular imaging. These imaging modalities include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance (MR) imaging, optical imaging (fluorescence and bioluminescence), and photoacoustic (PA) imaging. While antibody-based imaging agents may be employed for a broad range of diseases, this review focuses on the molecular imaging of @entity1 , as there are limited resources for imaging and treatment of @entity2 . Additionally, @entity1 remains the most lethal @entity0 with an overall 5-year survival rate of approximately 7%, despite significant advances in the imaging and treatment of many other @entity0 . In this review, we discuss recent advances in molecular imaging of @entity1 using antibody-based imaging agents. This task is accomplished by summarizing the current progress in each type of molecular imaging modality described above. Also, several considerations for designing and synthesizing novel antibody-based imaging agents are discussed. Lastly, the future directions of antibody-based imaging agents are discussed, emphasizing the potential applications for personalized medicine.

title: Molecular Imaging of XXXX with Antibodies.

answer: @entity1


abstract: OBJECTIVE: To investigate the effect of transcutaneous electrical nerve stimulation (TENS) on acupuncture points and neck exercise in @entity2 @entity0 . DESIGN: A randomized clinical trial. SETTING: Hospital-based practice. SUBJECTS: Two hundred and eighteen @entity0 with @entity2 . INTERVENTIONS: Subjects were randomized into three groups, receiving either (1) TENS over the acupuncture points plus infrared irradiation (TENS group); (2) exercise training plus infrared irradiation (exercise group); or (3) infrared irradiation alone (control); twice a week for six weeks. OUTCOME MEASURES: The values of verbal numeric @entity1 scale, Northwick Park Neck Pain Questionnaire, and isometric neck muscle strength were assessed before, at the end of the six-week treatment, and at the six-month follow-up. RESULTS: Results demonstrated that after the six-week treatment, significant improvement in the verbal numerical @entity1 scale was found only in the TENS group (0.60+/-2.54, p = 0.027) and the exercise group (1.57+/-2.67, p < 0.001). Though significant reduction in Northwick Park Neck Pain Questionnaire score was found in all three groups, post-hoc tests showed that both the TENS and the exercise group produced better improvement (0.38+/-0.60% and 0.39+/-0.62% respectively) than the control group (0.23+/-0.63%). Significant improvement (p = < 0.001 to 0.03) in neck muscle strength was observed in all three groups, however, the improvement in the control group was not clinically significant and it could not be maintained at the six-month follow-up. CONCLUSIONS: After the six-week treatment, @entity0 in the TENS and exercise group had a better and clinically relevant improvement in disability, isometric neck muscle strength, and @entity1 . All the improvements in the intervention groups were maintained at the six-month follow-up.

title: A randomized clinical trial of TENS and exercise for @entity0 with XXXX .

answer: @entity2


abstract: @entity3 are @entity2 accounting for a high percentage of @entity2 morbidity and mortality in @entity0 and young adults. Surgery and radiation therapy are the accepted treatments for most @entity3 ; however, @entity0 with @entity1 are treated with systemic chemotherapy. Many @entity2 display marginal levels of chemoresponsiveness and new treatment approaches are needed. Deregulation of the G1 checkpoint is crucial for various oncogenic transformation processes, suggesting that many @entity2 cell types depend on @entity8 activity. Thus, @entity8 activity appears to represent a promising therapeutic target for @entity2 treatment. In the present work, we explore the efficacy of @entity7 inhibition using palbociclib ( @entity9 ), a highly selective inhibitor of @entity8 , in a panel of @entity3 cell lines and @entity2 xenografts (PDXs). Palbociclib induces senescence in these cell lines and the responsiveness of these cell lines correlated with their levels of @entity7 mRNA. @entity9 is also active in vivo against @entity3 displaying high levels of @entity7 but not against @entity3 displaying low levels of @entity7 and high levels of @entity5 . The analysis of @entity2 growing after @entity9 showed a clear decrease in the @entity7 levels, indicating that clonal selection occurred in these treated @entity2 . In summary, our data support the efficacy of @entity7 inhibitors against @entity3 displaying increased @entity7 levels, particularly @entity6 and @entity4 . Our results also suggest that high levels of @entity5 may indicate poor efficacy of @entity7 inhibitors.

title: Efficacy of @entity7 inhibition against @entity3 depends on their levels of @entity7 and XXXX mRNA.

answer: @entity5


abstract: OBJECTIVE: We sought to explore whether @entity2 and @entity3 are predictive of entrapment. Study design and setting We retrospectively evaluated the data regarding orbital floor @entity1 in @entity0 younger than 19-years-old presenting at a tertiary care center from 1990 to 2001. Zygomatic, naso-orbital ethmoid, and displaced orbital rim @entity1 were excluded from our analysis. Data on the @entity1 type, signs and symptoms, ocular motility, surgical repair, and resolution of @entity4 were also collected. RESULTS: Twenty-nine orbital floor @entity1 were identified. One fourth of the @entity0 had @entity2 / @entity3 , and half had trapdoor @entity1 . Seventeen percent of @entity0 had entrapment of the inferior rectus. The positive predictive @entity5 with a trapdoor @entity1 for entrapment was 83.3% (P = 0.002, Fisher exact test). Half the @entity0 required surgical intervention, most commonly for @entity4 or gaze restriction. Gaze impairment did not resolve in 2 @entity0 . CONCLUSION: @entity0 with trapdoor @entity1 who present with @entity2 / @entity3 are at a high risk of inferior rectus entrapment and poor outcome.

title: Pediatric orbital floor fractures: XXXX / @entity3 as signs of entrapment.

answer: @entity2


abstract: Walking is generated by the interaction between neural rhythmic and physical activities. In fact, @entity2 ( @entity2 ), which is an example of disease, causes not only @entity4 but also @entity3 . However, the relationship between @entity4 and @entity3 has not been determined. The aim of this study was to identify the mechanism of gait rhythm generation. In former research, @entity4 in @entity2 @entity0 ' walking were characterized by stride intervals, which are more variable and fluctuate randomly. The variability and fluctuation property were quantified using the coefficient of variation (CV) and scaling exponent a. Conversely, because walking is a dynamic process, @entity1 ( @entity1 ) is considered the best way to estimate @entity3 in walking. Therefore, we classified the severity of @entity1 using CV and a. Specifically, @entity2 @entity0 and healthy elderly were classified into three groups: no- @entity1 , mild- @entity1 , and obvious- @entity1 . We compared the contributions of CV and a to the accuracy of this classification. In this study, 45 @entity2 @entity0 and 17 healthy elderly @entity0 walked 200 m. The severity of @entity1 was determined using the modified Hoehn-Yahr scale (mH-Y). @entity0 with mH-Y scores of 2.5 and 3 had mild- @entity1 and obvious- @entity1 , respectively. As a result, CV differentiated no- @entity1 from @entity1 , indicating the correlation between CV and @entity1 . Considering that @entity1 is independent of neural rhythm generation, this result suggests the existence of feedback process from physical activities to neural rhythmic activities. Moreover, a differentiated obvious- @entity1 from mild- @entity1 . Considering a reflects the intensity of interaction between factors, this result suggests the change of the interaction. Therefore, the interaction between neural rhythmic and physical activities is thought to plays an important role for gait rhythm generation. These characteristics have potential to evaluate the symptoms of @entity2 .

title: Relationship between @entity4 and @entity3 in XXXX @entity0 ' walking.

answer: @entity2


abstract: Localization of @entity7 to the pineal region is rare. The 7-year-old @entity0 now reported presented with an 18-month history of progressive @entity6 . CT and MRI scans demonstrated a 2.5x2.5 cm cyst at the pineal region with obstructive @entity4 . At surgery via an occipital transtentorial approach, a @entity1 " was encountered, and complete resection was achieved. We present the management of this @entity0 with pineal region epidermoid cyst and review 11 cases reported in the literature since 1968. In all, 8 of the 12 @entity0 were males. The age at the time of diagnosis ranged from 7 years to 69 years. @entity5 and @entity4 are the most common presenting findings. All but 1 @entity0 underwent direct surgical resection; 1 had stereotactic decompression. Surgical treatment brought about complete resolution of the presenting symptoms and signs in 10 of the 12 cases. One @entity0 had persistent upgaze palsy. One @entity0 died from progression of the pineal region mass. This @entity0 presented with @entity3 , which is a marker of clinical @entity2 . The authors advocate direct surgical attack as opposed to stereotactic diagnosis and aspiration to: (1) obtain maximal resection and thereby limit the potential for recurrence and delayed complications of the cyst; (2) possibly avoid shunt placement in @entity0 who present with @entity4 ; and (3) decrease the likelihood of sampling error.

title: XXXX of the pineal region.

answer: @entity7


abstract: BACKGROUND: @entity0 U three protein 14a ( @entity5 ) promotes @entity3 degradation. Moreover, @entity5 expression is upregulated in several types of @entity1 . However, the expression pattern of @entity5 in @entity2 ( @entity2 ) remains unknown. The aim of this study was to investigate @entity5 expression and its prognostic value in @entity2 . METHODS: The @entity5 expression was evaluated using immunohistochemistry (IHC) in @entity2 tissue specimens. The correlations between @entity5 expression and clinicopathological variables were analyzed. The Kaplan-Meier method was used to analyze the association between @entity5 expression and survival. Independent prognostic factors associated with @entity4 ( @entity4 ) and disease-free survival (DFS) were analyzed using the Cox proportional-hazards regression model. RESULTS: The IHC data revealed that the @entity5 positivity rate in @entity2 tissue specimens was significantly higher than that in nontumorous tissue specimens (89.9% vs. 72.7%, P < 0.05). The @entity5 expression was detected in both the nucleolus and the cytoplasm. The positivity rate of nucleolar @entity5 expression in @entity2 tissue specimens was higher than that in the nontumorous tissue specimens (29.3% vs. 10.1%, P < 0.05). No significant difference was found between @entity2 and nontumorous tissue specimens of cytoplasmic @entity5 expression (60.6% vs. 62.6%, P > 0.05). In addition, no significant correlation was found between nucleolar @entity5 expression and other clinicopathological variables. The 5-year @entity4 and DFS rates in @entity0 with positive nucleolar @entity5 expression were significantly lower than those in @entity0 with negative @entity5 expression (P = 0.004 for @entity4 , P = 0.003 for DFS). Multivariate analysis showed that nucleolar @entity5 expression was an independent prognostic factor for @entity4 (P = 0.004) and DFS (P < 0.001). CONCLUSIONS: The positivity rate of @entity5 expression was significantly higher in @entity2 specimens. Positive expression of nucleolar @entity5 might act as a novel prognostic predictor for @entity0 with @entity2 .

title: @entity0 U Three Protein 14a Expression is Increased in XXXX and Associated with Poor Prognosis.

answer: @entity2


abstract: The case records of 23 @entity0 with classic @entity3 ( @entity3 ), or @entity3 , seen at the National Skin Centre in Singapore, from 1990 to 2001 were reviewed. All @entity0 had clinical and histopathological findings consistent with @entity3 . There were eight @entity0 and 15 @entity0 (ratio 1:1.6). The mean age at presentation was 35 years. There was a marked predilection for Chinese @entity0 (87%), with a racial distribution of 20:2:1 of Chinese, Malay and Indian @entity0 , respectively. The most frequent site of occurrence was the face, particularly over both cheeks. The majority of @entity0 (90%) treated with oral @entity1 had a good response within 2-4 weeks. Relapses were frequent in 82.6% of @entity0 and maintenance with @entity1 or @entity2 was beneficial. @entity3 is a rare but important disease entity presenting with recurrent indurated erythematous papulopustules and plaques on the face. Increased awareness of this condition is important as it can mimic many other conditions presenting as red plaques on the face.

title: XXXX ( @entity3 ) in Singapore: a review of 23 adult cases.

answer: @entity3


abstract: The possible association of increased @entity3 ( @entity3 ) in @entity0 with increased serum @entity1 was observed in our clinic. Six @entity0 with confirmed @entity2 and hypercalcaemia were studied prospectively. Tc-99m sestamibi gated SPECT was done pre- and postoperatively. The @entity3 was abnormally high in all the @entity0 pre-operatively, i.e. above the normal reference range (47-61%) as used in our clinic. It decreased in all of them postoperatively, yet in only three @entity0 to values within the normal range. This was associated with normalisation of the serum @entity1 values. The median of the pre-operative @entity3 was 74% and postoperative it was 61.5%. The median difference was 9% with a 95% CI for the median difference for paired data (6; 26). This was statistically significant. Increased @entity3 was not previously described as part of the clinical picture of @entity2 . The in vivo effect of chronic hypercalcaemia on LV pump function my need to be revisited.

title: Enhanced myocardial contractility associated with hypercalcaemia of hyperparathyroidism - a case study in six XXXX .

answer: @entity0


abstract: OBJECTIVE: We evaluated therapeutic microcoil embolization in a group of @entity0 with severe @entity2 . MATERIALS AND METHODS: Twenty-seven @entity0 with severe @entity3 due to @entity1 (n = 19), @entity6 (n = 6), cecal @entity4 (n = 1), or unknown cause (n = 1) underwent attempted microcoil embolization (n = 25). Microcatheters were used in all procedures, and embolization was performed at the level of the vasa recta or the marginal artery of Drummond. Branches of the superior mesenteric artery were embolized in 12 @entity0 , branches of the inferior mesenteric artery were embolized in 12 @entity0 , and branches of both the superior and inferior mesenteric arteries were embolized in one @entity0 . RESULTS: Technical success was achieved in 93% (25/27) of the procedures. However, immediate hemostasis occurred in 96% (26/27) of @entity0 because in one failed procedure, an occlusive dissection of the inferior mesenteric artery arrested bleeding. Three @entity0 rebled within 24 hr. One @entity0 was treated with endoscopic cauterization, and two @entity0 underwent right hemicolectomy. One @entity0 who underwent right hemicolectomy for rebleeding had ischemic changes found on pathologic analysis of the resected specimen, and a second @entity0 who underwent embolization of branches of the superior and inferior mesenteric arteries developed @entity5 requiring left hemicolectomy. Prolonged clinical success occurred in 81% (22/27) of @entity0 . CONCLUSION: Therapeutic microcoil embolization for severe @entity2 is an effective and well-tolerated procedure.

title: Superselective microcoil embolization of XXXX .

answer: @entity2


abstract: OBJECT: The goal of this study was to investigate outcomes in @entity0 with @entity6 ( @entity6 ) who were treated with fractionated stereotactic radiotherapy (SRT). METHODS: One hundred one @entity0 with @entity6 were treated with fractionated SRT at a radiation level of 40 to 50 Gy administered in 20 to 25 fractions over a 5- to 6-week period. The median @entity1 size in these @entity0 was 19 mm (range 3-40 mm), and 27 @entity1 were larger than 25 mm. @entity0 were consistently followed up using magnetic resonance imaging every 6 months for 5 years in principle. The median follow-up period was 45 months. The actuarial 5-year rate of @entity1 control (no growth > 2 mm and no requirement for salvage surgery) was 91.4% (95% confidence interval 85.2-97.6%). Three @entity0 with progressive @entity1 underwent salvage @entity1 resection. The actuarial 5-year rate of useful hearing preservation (Gardner-Robertson Class I or II) was 71%. The observed complications of fractionated SRT included transient @entity5 (4% of @entity0 ), trigeminal @entity2 (14% of @entity0 ), and balance disturbance (17% of @entity0 ). No new permanent @entity3 occurred after fractionated SRT. Eleven @entity0 (11%) who had progressive communicating @entity4 ( @entity7 ) and no evidence of @entity1 growth after fractionated SRT required a shunt. The symptoms of this type of @entity4 were similar to those of normal-pressure @entity4 and occurred 4 to 20 months (median 12 months) after fractionated SRT. The mean size (+/- standard deviation) of @entity1 causing symptomatic @entity4 (25.5 +/- 7.8 mm) was significantly larger than that of other @entity1 (18.2 +/- 8.7 mm) (p = 0.011). Only four of the 72 @entity0 with @entity1 smaller than 25 mm in maximum diameter received a shunt. CONCLUSIONS: Fractionated SRT resulted in an excellent @entity1 control rate, even for relatively large @entity1 , and produced a high rate of hearing preservation that was comparable to the best results of single-fraction radiosurgery. The progression of communicating @entity4 should be monitored closely, particularly in @entity0 harboring a large @entity6 .

title: Management of @entity6 by fractionated stereotactic radiotherapy and associated XXXX .

answer: @entity7


abstract: The perivascular epithelioid cell has been proposed to be the unifying proliferating cell type in a number of lesions such as @entity6 , @entity12 , @entity7 . With the exception of rare examples of @entity6 , they are non-metastasizing. We report four examples of a new member of this family of @entity8 that occur in abdominopelvic location and show metastatic properties. The @entity0 , all @entity0 , were aged 19 to 41 years (mean, 32), and presented with a @entity3 mass involving the serosa of the ileum, uterus or pelvic cavity. Morphologically, the @entity3 were composed of sheets of large polygonal cells with glycogen-rich clear or eosinophilic cytoplasm and moderately pleomorphic nuclei, traversed by a delicate vasculature, mimicking @entity7 . There were areas of coagulative @entity4 and occasional mitotic figures. Intracytoplasmic brown pigment was present in two cases. Spindly cells, smooth muscle and fat were absent. @entity2 was present in all, lymph node @entity2 was documented in two and @entity2 to the ovary was present in one case. Two @entity0 developed widespread metastatic disease after 10 and 28 months from diagnosis. One @entity0 showed the clinical signs of @entity11 . In spite of the epithelial-like appearance, the @entity3 cells were negative for epithelial markers but were strongly positive with the melanogenesis-related marker HMB45. Another melanogenesis marker ( @entity13 ) was positive in two cases. Other markers including S-100 protein, @entity9 , @entity10 and @entity14 were negative. Thus, these @entity3 are not readily classifiable in the existing schema of known entities, and show overlapping morpho-phenotypic features of clear cell "sugar" @entity1 . We consider them as @entity5 composed of a pure population of uncommitted perivascular epithelioid cell, that lack modulation toward smooth muscle or adipose cells.

title: @entity5 of perivascular epithelioid cells. Report of four cases in young @entity0 , one with XXXX .

answer: @entity11


abstract: BACKGROUND: Recent clinical trials using @entity9 + @entity0 cardiac stem cells (CSCs) demonstrated promising results in increasing cardiac function and improving quality of life. However, CSC efficiency is low, likely due to limited cell survival and engraftment after transplantation. The Rho-associated protein kinase (ROCK) inhibitor, @entity11 , significantly increased cell survival rate, adhesion, and migration in numerous types of cells, including stem cells, suggesting a common feature of the ROCK-mediated apoptotic pathway that may also exist in @entity0 CSCs. In this study, we examine the hypothesis that pretreatment of @entity0 CSCs with @entity11 protects cells from @entity7 ( @entity10 ) induced apoptosis. METHODS AND RESULTS: @entity9 + CSCs were cultured in CSC medium for 3-5 days followed by 48hr treatment with 0 to 10 M @entity11 alone, 0 to 1.0 M @entity10 alone, or @entity11 followed by @entity10 (48hrs). Cell viability, @entity2 , proliferation, morphology, migration, @entity3 activity, expression levels of apoptotic-related key proteins and @entity9 + were examined. Results showed that 48hr treatment with @entity11 alone did not result in great changes in @entity9 + expression, proliferation, @entity3 activity, or apoptosis; however cell viability was significantly increased and cell migration was promoted. These effects likely involve the ROCK/Actin pathways. In contrast, 48hr treatment with @entity10 alone dramatically increased @entity3 activity, resulting in cell death. Although @entity11 alone did not affect the expression levels of apoptotic-related key factors (p- @entity4 , @entity4 , @entity5 , @entity8 , @entity6 , cleaved @entity3 , and @entity3 ) under basal conditions, it significantly inhibited the @entity10 -induced increase in cleaved @entity3 and reduced cell death under @entity10 treatment. CONCLUSIONS: We conclude that preconditioning @entity0 CSCs with @entity11 significantly reduces @entity10 -induced cell death and possibly involves the cleaved @entity3 and ROCK/Actin pathways. The beneficial effects of @entity11 may be applied to stem cell-based therapy to increase cell survival rates after transplantation or to act as a cardiac protective agent for @entity10 -treated @entity1 @entity0 .

title: Rho-Associated Kinase Inhibitor ( @entity11 ) Attenuates XXXX -Induced Apoptosis of @entity0 Cardiac Stem Cells.

answer: @entity7


abstract: OBJECTIVE: To evaluate the therapeutic potential of @entity8 ( @entity8 ) in @entity3 ( @entity3 ) and @entity2 ( @entity2 ) by examining regulation of cytokine antagonist expression. METHODS: Expression of @entity6 ( @entity6 ) and soluble @entity1 necrosis factor receptor (sTNFR) was examined by ELISA in cells from freshly isolated synovial fluids (SF) and synovial tissues (ST) from @entity0 with @entity3 or @entity2 , either left untreated or treated with @entity8 . Single (7) and paired (5) SF and ST cells from @entity3 and @entity2 @entity0 were examined. As well, the ability of @entity8 to regulate gene expression levels for @entity7 ( @entity7 ) and @entity9 ( @entity9 ) was examined in freshly isolated SF cells from @entity0 with @entity2 , by reverse transcriptase polymerase chain reaction. RESULTS: @entity6 and sTNFR were found to be constitutively expressed in @entity3 and @entity2 SF and ST cells. @entity8 treatment resulted in an increase in both @entity6 and sTNFR production. Freshly isolated @entity2 SF cells exhibited constitutive @entity9 gene expression in both the @entity5 and T cell fractions of the SF. In contrast, @entity7 gene expression levels were undetectable or low. @entity8 treatment of @entity2 SF cells resulted in upregulation of @entity7 gene expression in the T cell fraction of the @entity2 SF cells, whereas @entity9 gene expression remained unaffected. CONCLUSION: These in vitro data suggest a therapeutic role for @entity8 in the treatment of @entity4 through upregulation of critical cytokine antagonists.

title: Therapeutic implications for interferon-alpha in XXXX : a pilot study.

answer: @entity4


abstract: @entity4 + @entity5 presenting in the skin are rare. We describe the clinical and histological features of 18 @entity0 with @entity4 + cutaneous @entity1 , which have been divided into four groups. Seven @entity0 had precedent long histories of rashes, which progressively spread in a presentation similar to that of @entity3 + @entity8 ( @entity8 ). Three @entity0 had long-standing localized plaques consistent with a @entity12 ( @entity12 ) pattern. Two @entity0 presented with @entity9 and had peripheral blood involvement consistent with a @entity11 ( @entity11 ) pattern and had rapidly progressive clinical courses. Six @entity0 presented with cutaneous nodules of varying sizes and had variable outcomes, with two having rapidly progressive disease, two with indolent recurrences and a further two with complete responses to treatment. Histologically, 12 of the 18 cases showed an @entity1 infiltrate that was most marked in the three @entity12 cases. @entity6 was seen in 11 cases. Similar to @entity3 + @entity8 , the skin-homing antigen, (cutaneous lymphocyte antigen: @entity7 ), was strongly expressed in 13 of 16 tested cases. Expression of the cytotoxic granule protein @entity10 was noted in a majority of @entity1 cells in only three of 16 tested cases. We conclude that approximately half of @entity4 + @entity5 clinically and histologically resemble @entity3 + @entity8 / @entity11 , whereas presentation as @entity2 are more common in @entity4 + @entity1 as compared to those that express @entity3 .

title: Clinical and pathological spectrum of @entity4 -positive XXXX .

answer: @entity5


abstract: BACKGROUND: @entity3 ( @entity3 ) is a poorly understood condition associated with periods of emotional and physical stress. The clinical approaches for management of @entity3 are supportive and reactive to @entity0 symptoms. OBJECTIVE: To utilize next-generation exome sequencing to define genetic variation associated with, and potentially responsible for, this disease. METHODS: We performed exome sequencing of 7 white female @entity0 with @entity3 . Filtering of the identified variants was performed to limit our investigation to those sequences that passed quality control criteria, were rare or novel, were determined algorithmically to have high impact on the associated protein, and were within regions of high species conservation. All variants were verified by using Sanger sequencing. RESULTS: Exome-sequencing analysis revealed that each @entity0 carried predicted deleterious variants affecting known @entity1 genes. In each case, the identified variant was either not previously found in public @entity0 genome data or was previously annotated in a database of clinical variants associated with @entity2 . CONCLUSION: @entity0 with @entity3 harbor deleterious mutations in established @entity1 genes at a level higher than healthy controls. We hypothesize that @entity0 at highest risk for @entity3 likely live in a compensated state of @entity2 that manifests clinically only after the myocardium is stressed. In short, we propose that @entity3 is another example of an @entity1 with a distinct physiological trigger and suggest that alternative clinical approaches to these @entity0 may be warranted. ABBREVIATIONS: CADD, Combined Annotation Dependent DepletionFPKM, fragments per kilobase pair of exon per million fragments mappedNHLBI GO ESP, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing ProjectPCR, polymerase chain reactionSIC, stress-induced @entity1 .

title: Rare Variants in XXXX Genes Associated With Stress-Induced @entity1 .

answer: @entity1


abstract: @entity2 is the most common reason why @entity0 see a physician. Within the USA, it has been estimated that at least 116 million US adults suffer from @entity4 , with an estimated annual national economic cost of  560-635 billion. While @entity2 is in part a sensory process, like sight, touch, or smell, @entity2 is also in part an emotional experience, like @entity3 , @entity1 , or anger. Thus, @entity4 is arguably the quintessential biopsychosocial condition. Due to the overwhelming evidence of the biopsychosocial nature of @entity2 and the value of psychological assessments, the majority of @entity4 guidelines recommend a psychological evaluation as an integral part of the diagnostic workup. One biopsychosocial inventory designed for the assessment of @entity0 with @entity4 is the Battery for Health Improvement 2 (BHI 2). The BHI 2 is a standardized psychometric measure, with three validity measures, 16 clinical scales, and a multidimensional assessment of @entity2 . This article will review how the BHI 2 was developed, BHI 2 concepts, validation research, and an overview of the description and interpretation of its scales. Like all measures, the BHI 2 has strengths and weaknesses of which the forensic psychologist should be aware, and particular purposes for which it is best suited. Guided by that knowledge, the BHI 2 can play a useful role in the forensic psychologist's toolbox.

title: The Psychological Evaluation of XXXX with @entity4 : a Review of BHI 2 Clinical and Forensic Interpretive Considerations.

answer: @entity0


abstract: BACKGROUND: Some @entity0 with @entity3 have generalized @entity2 (GTCS) while others have only partial @entity2 (PS). We investigated the relationship between @entity1 localization and @entity2 generalization using quantitative lesion mapping on magnetic resonance images. METHODS: Twenty one @entity0 with histologically proven @entity3 and GTCS (n=11) or PS (n=10) were studied. Data were acquired on a 3 Tesla MRI System. We performed lesion mapping techniques to compare the spatial distribution of @entity3 between @entity0 groups, and quantitatively determined the extent to which lesions intersected each probabilistic regions-of-interest, including the cerebral lobes, thalamus, striatum, and genu of the corpus callosum. RESULTS: In @entity0 experiencing GTCS, the greatest lesion load was observed in mesial frontal regions, including cortex connected to the genu. In contrast, the greatest lesion load in @entity0 experiencing PS was observed more caudo-laterally in orbitofrontal and temporal lobes, but typically sparing cortex connected to the genu. The number of lesion intersections with genu region of interest was significantly greater in @entity0 experiencing GTCS relative to @entity0 with PS (p=0.03). There were no significant differences between @entity0 groups with respect to lesion intersection with the individual cerebral lobes, thalamus and striatum, or with respect to overall @entity3 size. CONCLUSION: Our data suggest that the genu of the corpus callosum may be a major pathway for @entity2 generalization in @entity0 with @entity3 .

title: The role of the corpus callosum in XXXX spread: MRI lesion mapping in @entity3 .

answer: @entity2