abstract: INTRODUCTION: Topical @entity3 ( @entity3 ) has been used to treat @entity4 for decades. It has been an important and effective treatment which the @entity0 can self-administer, but is limited by the surface area of skin to be treated (according to the manufacturer's guidelines) of 500  cm(2). Other topical treatments can be @entity2 , or require hospital/health care professional input. The use of @entity3 under occlusion (chemowraps) for large areas of sun-damaged skin on the arms or legs has been described and is a potentially useful treatment option. We describe our experiences with this technique in the Norfolk and Norwich University Hospital Dermatology Department (Norwich, UK). METHODS: Five @entity0 were recruited into this pilot study. Topical @entity3 was applied to sun-damaged limbs under occlusion, and reviewed weekly for response, and local or systemic side effects. Treatment duration was 12-14  weeks. Clinical photography was undertaken prior to, during, and after treatment to document response. RESULTS: We show that there was substantial clinical improvement in the treated skin in our @entity0 . Experienced dermatologists reviewed all the @entity0 , and documented the changes photographically, and by counting lesions. All @entity0 were satisfied with their treatment regimen, and also with the end result; although two did not complete the treatment regimen due to complications not directly attributable to the treatment. CONCLUSION: Topical @entity3 under occlusion (chemowraps) may be a valid treatment option for large areas of sun-damaged skin with field cancerization changes, due to low systemic and local @entity1 , and acceptability to @entity0 .

title: XXXX "Chemowraps" in the Treatment of Multiple Actinic Keratoses: A Norwich Experience.

answer: @entity3


abstract: The association of kefir microbiota was observed by electron microscopic examination. Scanning electron microscopic (SEM) observations revealed that kefir grain surface is very rough and the inner portions had scattered irregular holes on its surface. The interior of the grain comprised fibrillar materials which were interpreted as protein, lipid and a soluble polysaccharide, the kefiran complex that surrounds @entity0 and bacteria in the grain. @entity0 was observed more clearly than bacteria on the outer portion of the grain. Transmission electron microscopic (TEM) observations of kefir revealed that the grain comprised a mixed culture of @entity0 and bacteria growing in close association with each other. Microbiota is dominated by budded and long-flattened @entity0 cells growing together with lactobacilli and lactococci bacteria. Bacterial cells with rounded ends were also observed in this mixed culture. Kefir grains, kefir suspensions, and kefiran were tested for antimicrobial activities against several bacterial and fungal species. The highest activity was obtained against @entity1 KR6 and @entity4 CZ1. Growth of @entity3 AH3 producing for @entity2 for 10 days in broth medium supplemented with varying concentrations of kefir filtrate (%, v/v) showed that sporulation was completely inhibited at the higher concentrations of kefir filtrate (7-10%, v/v). The average values of both mycelial dry weights and @entity2 were completely inhibited at 10% (v/v). This is the first in vitro study about the antifungal characteristics of kefir against filamentous fungi which was manifested by applying its inhibitory effect on the productivity of @entity2 by A. flavus AH3.

title: Milk kefir: ultrastructure, antimicrobial activity and efficacy on @entity2 production by XXXX .

answer: @entity3


abstract: BACKGROUND: Isolated @entity6 in the anterior cerebral artery (ACA) territory is rare, and its etiology has not yet been fully elucidated. Thus, we aimed to determine the etiologic and clinical characteristics of @entity0 with isolated ACA territory @entity4 due to @entity5 . METHODS: Of 2315 @entity0 with @entity3 admitted to our hospital between April 2007 and September 2013, 34 @entity0 (1.5%; 28 @entity0 , 6 @entity0 ; mean age, 65      15  years) suffered isolated ACA territory @entity4 . We performed cranial magnetic resonance (MR) imaging and MR angiography for all the @entity0 . Whenever possible, we also performed 3-dimensional computed tomography angiography, digital subtraction angiography, and MR cisternography to diagnose the @entity2 subtype. RESULTS: The @entity2 subtypes of the 34 @entity0 with isolated ACA territory @entity4 were @entity4 , @entity4 , @entity5 , and unclassified in 11 @entity0 (32%), 11 @entity0 (32%), 11 @entity0 (32%), and 1 @entity0 (3%), respectively. The mean ages at onset were 48      9 and 72      11  years in the dissection and nondissection groups, respectively (P  <  .001). Headaches were present at onset in 4 @entity0 (36%) and 1 @entity0 (4%) with and without dissection, respectively (P  =  .026). Blood pressure at onset was significantly higher among @entity0 with dissection (systolic, 179      34 mm Hg; diastolic, 102      17 mm Hg) than among @entity0 without dissection (systolic, 155      30 mm Hg; diastolic, 86      21 mm Hg; P  <  .05), and d-dimer values were significantly lower among @entity0 with dissection (P  =  .034). Favorable clinical outcome (modified Rankin Scale score, 0-2) at discharge was achieved in 9 @entity0 (82%) and 10 @entity0 (43%) with and without dissection, respectively (P  =  .035). CONCLUSIONS: @entity0 with isolated ACA territory @entity4 demonstrated a relatively high frequency of dissection (32%). @entity0 with dissection were younger, had a higher frequency of @entity1 , and demonstrated more favorable prognoses than @entity0 without dissection.

title: Research Article: Clinical Characteristics of Isolated Anterior Cerebral Artery Territory Infarction due to XXXX .

answer: @entity5


abstract: OBJECTIVES: To compare the efficacy and safety of @entity3 (EO) as a sclerosing agent, vs. absolute @entity2 (AE), in the treatment of symptomatic simple @entity1 . @entity0 AND METHODS: Between November 2009 and October 2012, 46 @entity0 were prospectively randomised into two groups. All @entity0 presented with a simple @entity1 underwent ultrasonographic aspiration and injection of a sclerosing agent. In group 1, 25 @entity0 had the cyst injected with EO, and in group 2, 21 were treated with AE. One injection was used in cysts of <200  mL and two injections were used in larger cysts. Complete and partial success were defined as complete cyst ablation or a >50% reduction in cyst volume with symptomatic relief, respectively. @entity0 were followed up using semi-annual ultrasonography and computed tomography for 2  years. RESULTS: Sclerotherapy was technically successful in all @entity0 . There was no significant difference in cyst volume between the groups. After    2 years of follow-up there was complete symptomatic relief in both groups, and the overall radiological success rate was 100% of both groups, at 79% complete and 21% partial in group 1, and 83% complete and 17% partial in group 2. The frequency of transient complications in the form of microscopic haematuria was 7% and 13%, and of low-grade fever in 4% and 10% in groups 1 and 2, respectively. CONCLUSION: EO can replace AE as a sclerosing agent for symptomatic simple @entity1 , as it has comparable efficacy with higher safety and tolerance.

title: XXXX vs. absolute @entity2 as sclerosing agents for treating symptomatic simple @entity1 .

answer: @entity3


abstract: UNASSIGNED: A large proportion of @entity0 with @entity6 movement @entity2 (iRBD) develop a synucleinopathy, mostly @entity4 , @entity5 with @entity7 , and @entity8 . Therefore, identifying markers of @entity3 in iRBD could have major implications. We aimed to assess the usefulness of electroencephalography (EEG) spectral analysis performed during wakefulness for predicting the development of a @entity3 in iRBD. Fifty-four iRBD @entity0 , 28 of whom developed @entity4 , @entity8 , or @entity5 with @entity7 (mean follow-up: 3.5  years), and 30 healthy controls underwent at baseline a resting-state waking EEG recording, neurological exam, and neuropsychological assessment. Absolute and relative spectral powers were analyzed for 5 frequency bands in frontal, central, parietal, temporal, and occipital regions. The slow-to-fast [(    +   )/(b1  + b2)] power ratio for each of the 5 cortical regions and the dominant occipital frequency were calculated as an index of @entity1 . @entity0 who developed disease showed higher absolute delta and theta power in all 5 cortical regions compared to disease-free @entity0 and controls. The slow-to-fast power ratio was higher in all regions in @entity0 who developed disease than in the 2 other groups. Moreover, @entity0 who developed disease had a slower dominant occipital frequency compared to controls. The only significant difference observed between disease-free iRBD @entity0 and controls was higher absolute delta power in frontal and occipital regions in iRBD @entity0 . Specific EEG abnormalities were identified during wakefulness in iRBD @entity0 who later developed a synucleinopathy. EEG slowing is a promising marker of @entity3 in iRBD @entity0 .

title: Electroencephalogram slowing predicts @entity3 in XXXX movement @entity2 .

answer: @entity6


abstract: UNASSIGNED: Adipose tissue expansion has been associated with system-wide metabolic dysfunction and increased vulnerability to @entity1 , @entity0 , and @entity3 .  A reduction in adiposity is a hallmark of caloric restriction (CR), an intervention that extends longevity and delays the onset of these same age-related conditions. Despite these parallels, the role of adipose tissue in coordinating the metabolism of @entity4 is poorly defined. Here, we show that adipose tissue metabolism and secretory profiles change with age and are responsive to CR. We conducted a cross-sectional study of CR in adult, late-middle-aged, and advanced-aged @entity2 . @entity5 and the relationship between adiposity and circulating levels of the adipose-derived peptide hormone @entity9 were age-sensitive. CR impacted adiposity but only levels of the high molecular weight isoform of @entity9 responded to CR. Activators of metabolism including @entity7 , @entity8 , and @entity10 were differentially expressed with CR in adipose tissues. Although age had a significant impact on @entity6 metabolism, as detected by biochemical assay and multiphoton imaging, the impact of CR was subtle and related to differences in reliance on oxidative metabolism. The impact of age on circulating lipids was limited to composition of circulating phospholipids. In contrast, the impact of CR was detected in all lipid classes regardless of age, suggesting a profound difference in lipid metabolism. These data demonstrate that aspects of adipose tissue metabolism are life phase specific and that CR is associated with a distinct metabolic state, suggesting that adipose tissue signaling presents a suitable target for interventions to delay @entity4 .

title: Aging and caloric restriction impact adipose tissue, XXXX , and circulating lipids.

answer: @entity9


abstract: UNASSIGNED: Small cell @entity3 , hypercalcemic type is a very rare aggressive @entity2 of unknown histogenesis, affecting mainly @entity0 and young @entity0 . Recently, inactivating mutations in @entity9 ( @entity9 ), a member of the switch/ @entity6 nonfermenting chromatin remodeling complex, has been identified as driver events in most cases. We herein describe 3 cases in 34, 34, and 37-year-old @entity0 . Symptoms were mainly abdominal pain and mass. One @entity0 was normocalcemic, and the other 2 had no preoperative serum @entity4 values available. All @entity0 received radical hysterectomy with salpingo-oophorectomy, lymphadenectomy, and variable multimodality therapy. Two developed abdominal recurrences/ @entity1 and died of disease at 4 and 12 months. One @entity0 was alive without disease 17 months after surgery and radiochemotherapy. Histologic examination showed undifferentiated @entity2 composed of diffuse sheets, nests and cords of noncohesive monomorphic small blue/basaloid cells (classic variant, 1 case), and large undifferentiated/rhabdoid cells with abundant cytoplasm (large cell/rhabdoid variant, 2 case) admixed with minor small cell areas. One case contained rare isolated goblet cells, but true glandular component was absent. All @entity2 expressed vimentin and variably pancytokeratin and @entity8 . Nuclear @entity7 was intact in all cases (1 case showed small foci with mosaic loss). All @entity2 showed complete loss of @entity9 . In conclusion, @entity9 immunohistochemistry represents a highly valuable emerging tool in identifying small cell @entity3 , hypercalcemic type in routine practice. Distinguishing this aggressive @entity2 from @entity5 and other undifferentiated @entity3 is mandatory in selecting appropriate chemotherapeutic regimens and would allow better characterization of this entity, for which targeted molecular therapy still remains to be established.

title: XXXX -deficient undifferentiated @entity3 (small cell carcinoma, hypercalcemic type): clinicopathologic and immunohistochemical study of 3 cases.

answer: @entity9


abstract: Strabismus caused by @entity3 can be the result of localized acute soft tissue swelling or may follow @entity4 , partial or complete loss of extraocular muscle (EOM) and/or @entity1 , or damage to surrounding tissues causing mechanical restriction. The strabismus is frequently incomitant and can be difficult, if not impossible to completely correct. The resulting @entity2 can affect the individual's ability to function at work, in sports and in common tasks of daily living like driving. The preoperative evaluation should include an assessment of the degree of limitation, muscle function and the condition of the surrounding tissue. In most cases, high resolution computed tomography and/or surface coil dynamic magnetic resonance imaging are required to determine the extent and nature of suspected bony or EOM injury, as well as muscle contractility. If the scan reveals an intact but paretic muscle or only minor @entity0 , surgical intervention is based on the degree of muscle recovery 6 months after the initial insult. If a rectus muscle has been lacerated, and the proximal stump is functional, retrieval should be attempted, either by a direct conjunctival approach if located anteriorly, or by an anterior medial orbitotomy if located deep in the orbit. If a damaged muscle cannot be found, recovered or repaired at any time, then muscle transposition should be considered. If multiple muscles are damaged or scar tissue is excessive, a tether procedure may be indicated. This paper will present an approach to some aspects of strabismus in this setting.

title: An Approach to Some Aspects of Strabismus from XXXX .

answer: @entity3


abstract: STUDY OBJECTIVE: We identify characteristics of @entity0 with @entity2 or @entity3 associated with favorable assessments of @entity1 ( @entity1 ) effectiveness and 30-day quality of life. METHODS: As part of a prospective observational study of @entity1 management and short-term outcomes of @entity0 with nonvalvular @entity2 or @entity3 , we adapted a disease-specific quality-of-life instrument. By telephone, we administered the @entity2 Effect on Quality-of-life survey to @entity0 30 days after an @entity1 visit in which they were treated for newly diagnosed or recent-onset @entity2 or @entity3 and discharged home. We also asked respondents to rate the effectiveness of @entity1 treatment. Using data prospectively collected in the @entity1 and extracted from electronic health records, we recorded rhythm management (cardioversion attempts and type) and @entity0 and @entity1 treatment characteristics. Using multivariable regression, we examined the association between these characteristics and @entity0 -reported effectiveness of @entity1 treatment ("very effective" or not) and any @entity2 or @entity3 quality-of-life effect. RESULTS: Six hundred fifty-two eligible @entity1 @entity0 (response rate 89%) treated between May 2011 and November 2012 completed follow-up. Of these @entity0 , 454 (69.6%) reported that their @entity1 treatment was "very effective" and 113 (17.3%) reported no quality-of-life influence. In multivariable analyses, there was an association between @entity1 electrocardioversion and perceived @entity1 effectiveness (P<.05) but none between treatment strategy and 30-day @entity2 or @entity3 quality-of-life score. Respondents who were younger, @entity0 , and had worse pre- @entity1 self-reported health (P<.05) were more likely to report a quality-of-life effect. CONCLUSION: In this observational study, @entity1 rhythm management strategy was associated with greater perceived effectiveness of the @entity1 visit but not with a difference in 30-day quality-of-life score.

title: Emergency Department Management of @entity2 and Flutter and XXXX Quality of Life at One Month Postvisit.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: With the increased investigation of cerebral arteries using magnetic resonance angiography in the general population, the detection of unruptured @entity4 (UIAs) has increased. Understanding the distribution and factors associated with UIAs might be helpful for understanding the pathomechanism. METHODS: Subjects who underwent magnetic resonance angiography with a health examination at the Health Screening and Promotion Center were enrolled. The incidence and risk factors of UIAs (age, sex, @entity2 , @entity1 , smoking, @entity3 , and @entity6 ) were investigated by comparing @entity0 with and without UIAs. These risk factors were also investigated by the UIA location, distal internal carotid artery, anterior cerebral artery and middle cerebral artery (MCA), MCA bifurcation, anterior and posterior communicating artery, and posterior circulation. RESULTS: Among 187 166 subjects who received health examination, 18 954 underwent magnetic resonance angiography. Of them, 367 (1.93%) had UIAs. Age (odds ratio [OR], 1.02; P=0.003), @entity0 (OR, 2.00; P<0.001), @entity2 (OR, 2.21; P<0.001), smoking (OR, 1.66; P=0.001), and @entity6 (OR, 0.23; P<0.001) were independently associated with the presence of UIAs. @entity2 was associated with most UIAs, except for those located at sidewalls (anterior cerebral artery and MCA). MCA @entity5 were associated with old age and smoking. Distal internal carotid artery, posterior communicating artery, and MCA-bifurcation @entity5 were associated with female sex. Anterior communicating artery @entity5 were associated with smoking and @entity3 . Posterior circulation UIAs were only associated with @entity2 . @entity6 was negatively associated with anterior circulation @entity5 . CONCLUSIONS: The risk factors for UIAs differ by their location, compared with the control. Interestingly, the presence of @entity6 was protective against the presence of UIAs.

title: Risk Factors Associated With the Presence of Unruptured XXXX .

answer: @entity4


abstract: Between 1982 and 1995 116 @entity0 underwent operations because of NC of the liver, 18 of them were operated on by laparoscopic way. There were 94 male (mean age: 51.9 years) and 66 female (mean age: 54.6 years) @entity0 . The mean size of the cysts were 57.4 mm in diameter (20-140 mm), In 94 cases they were solitary and in 11 they were multiple. In 31 cases we performed an enucleation, in 60 cases a fenestration and in one case a punction of the cysts. A liver resection had to be carried out in two cases. In 18 cases the fenestration of the cysts was performed by laparoscopy and in 10 cases cholecystectomy was simultaneously carried out. The most common complications were @entity2 and wound suppuration. There was no mortality. Another 26 @entity0 with NC have been treated with ultrasound guided puntion of the @entity1 . The cysts were solitary in twenty-three cases and multiple in three other cases. The number of the cysts were thirty-two. One case had to be operated on because of recurrence of the cyst. Mortality could not be observed. In the laparotomized group the average time of the hospitalisation was 14.3 days, and among the @entity0 who were operated on by laparoscopic way 7.0 days. An intervention is indicated only in case of severe complaints or the growing of the lesion. Recently we prefer the ultrasound guided punction or the fenestration of the @entity1 by means of the laparoscopic way.

title: Laparoscopic deroofing of nonparasitic XXXX . Comparison different methods.

answer: @entity1


abstract: We present the statistics for mortality in Navarre for the 1995-2004 period by sex, age and cause of @entity6 . METHODS: The data proceeds from the statistical bulletins on @entity6 . The 1995-1999 period is compared with the 2000-2004 period, using adjusted rates to the population of Navarre for the year 2001 and the rate of potential years of life lost between 0-70 years adjusted to the European population. RESULTS: Life expectancy at birth in the 2000-2004 period was 77.9 years in @entity1 and 85 years in @entity1 , the latter being one of the highest registered at the world level. @entity1 mortality fell to 3.3 per 1,000 living newborn @entity1 . The risk of @entity6 has fallen in practically all age groups, with a notable fall in mortality of 40% in the 25-34 group at the cost of @entity10 . There has been a significant increase of mortality due to @entity2 amongst @entity1 under 65 years of age (46%) in the 2000-2004 period with respect to the previous five year period and a sharp fall in mortality due to @entity0 (45.4%). In both sexes there has been a continued fall of mortality due to @entity4 , @entity8 , @entity9 and @entity12 and of mortality due to @entity11 and @entity5 . The rates of mortality in Navarre in all the main groups of causes are lower than those of Europe, except for the rate of mortality due to external causes. CONCLUSIONS: The increase of mortality due to @entity2 and other @entity3 related to smoking, due to the spread of consumption in recent decades, could have a negative influence on the life expectancy of @entity1 in Navarre in coming years. The prevention of mortality due to external causes and the prevention of @entity6 linked to @entity7 consumption are the two priorities that emerge from the data on mortality in this autonomous community.

title: [Recent trends of the main causes of XXXX in Navarre. 1995-2004].

answer: @entity6


abstract: @entity5 ( @entity5 ) inactivating mutations are present in most @entity0 @entity1 . The @entity5 protein regulates the b-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated transcription in Wnt pathway signaling. We studied effects of reduced dosage of the @entity7 gene encoding b-catenin in Apc-mutation-induced colon and ovarian @entity2 tumorigenesis and cell culture models. Concurrent somatic inactivation of one @entity7 allele, dramatically inhibited Apc mutation-induced @entity5 and greatly extended Apc-mutant @entity2 survival. @entity7 hemizygous dose markedly inhibited increases in b-catenin levels in the cytoplasm and nucleus following Apc inactivation in colon epithelium, with attenuated expression of key b-catenin/TCF-regulated target genes, including those encoding the EphB2/B3 receptors, the stem cell marker @entity9 , and @entity8 , leading to maintenance of crypt compartmentalization and restriction of stem and proliferating cells to the crypt base. A critical threshold for b-catenin levels in TCF-regulated transcription was uncovered for Apc mutation-induced effects in colon epithelium, along with evidence of a feed-forward role for b-catenin in @entity7 gene expression and @entity7 transcription. The active b-catenin protein pool was highly sensitive to @entity7 transcript levels in @entity4 cells. In @entity2 @entity3 ( @entity3 ) arising from Apc- and @entity6 -inactivation, while @entity7 hemizygous dose affected b-catenin levels and some b-catenin/TCF target genes, @entity8 induction was retained and @entity3 arose in a fashion akin to that seen with intact @entity7 gene dose. Our findings indicate @entity7 gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis. Differential expression of selected b-catenin/TCF-regulated genes, such as @entity8 , likely underlies context-dependent effects of @entity7 gene dosage in tumorigenesis.

title: Tissue-Specific Effects of Reduced b-catenin Expression on XXXX Mutation-Instigated Tumorigenesis in @entity2 Colon and Ovarian Epithelium.

answer: @entity5


abstract: UNASSIGNED: The prevalence of @entity1 ( @entity1 ) and @entity2 ( @entity2 ) among Latinas is comparable to those of the general population; however, few interventions and treatment trial research have focused on this group. Cognitive-behavioral therapy (CBT) is the treatment of choice for @entity2 . CBT-based guided self-help (CBTgsh)-a low-cost minimal intervention-has also been shown effective in improving @entity3 related symptom, but the effectiveness of the CBTgsh among ethnic minority @entity0 is not well understood. Cultural adaptation of evidence-based treatments can be an important step for promoting treatment accessibility and engagement among underserved groups. This qualitative study was part of a larger investigation that examined the feasibility and efficacy of a culturally adapted CBTgsh program among Mexican American @entity0 with @entity2 . Posttreatment focus groups were conducted with 12 Mexican American @entity0 with @entity1 or @entity2 who participated in the intervention. Data were analyzed with the grounded theory methodology (Corbin _ Strauss, 2008). Three themes emerged from the data: (a) eating behavior and body ideals are socially and culturally constructed, (b) multifaceted support system is crucial to Mexican American @entity0 's treatment engagement and success, and (c) the culturally adapted CBTgsh program is feasible and relevant to Mexican American @entity0 's experience, but it can be strengthened with increased family and peer involvement. The findings provide suggestions for further adaptation and refinement of the CBTgsh, and implications for future research as well as early intervention for disordered eating in organized care settings. (PsycINFO Database Record

title: Mexican American XXXX 's perspectives on a culturally adapted cognitive-behavioral therapy guided self-help program for @entity3 .

answer: @entity0


abstract: Because the paired lobes (ventral, dorsal, lateral, and anterior) of the @entity2 prostate have not been consistently sampled in many carcinogenicity and @entity5 studies, comparison among different investigations has been compromised. The lack of specific site identification for @entity13 further lessens the value of incidences reported. We present here the lobe-specific incidences and degree of severity of background prostatic, seminal vesicular, and @entity4 in 1768 control Fischer-344 @entity2 from 35 recent National Toxicology Program 2-year carcinogenicity and @entity5 studies conducted in 4 laboratories. The dorsal and lateral lobes were combined and considered the dorsolateral lobe where @entity1 , epithelial degeneration, @entity3 , and @entity0 were observed. @entity1 in the dorsolateral lobes was significantly associated with @entity8 whose @entity12 was suggested to play an important role in pathogenesis of @entity9 . @entity6 , @entity11 , @entity1 , @entity0 , and @entity7 were @entity10 . @entity1 and @entity0 occurred in the anterior lobes (coagulating glands). @entity1 , dilatation, @entity11 , @entity0 , and @entity7 were observed in the seminal vesicles. @entity1 was also present in the ampullary glands. We suggest an optimal embedment and trimming method in @entity2 prostate and seminal vesicle to ensure adequate, consistent sampling.

title: A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 XXXX .

answer: @entity2


abstract: UNASSIGNED: Complement-dependent @entity1 (CDC) has been suggested to be an important mechanism of action of @entity0 -targeting Abs. However, single unmodified @entity2 ( @entity2 )-targeting IgG1 Abs fail to trigger efficient CDC. For the current study, we generated a CDC-optimized variant of the @entity2 Ab matuzumab (H425 wt) by introducing @entity4 substitutions @entity5 / @entity6 (H425 mt). This Ab was then used to elucidate the impact of complement activation on the capacity of effector cells such as mononuclear cells (MNC) and polymorphonuclear cells (PMN) to exert @entity1 ( @entity1 ). H425 mt, but not H425 wt, significantly induced complement deposition, release of anaphylatoxins, and CDC against distinct @entity0 cell lines, whereas no differences in @entity1 by MNC or PMN were detected. Notably, stronger @entity1 was induced by H425 mt than by H425 wt in whole blood assays and in experiments in which MNC or PMN were combined with serum. Although MNC- @entity1 was not affected by C5 cleavage, the cytotoxic activity of PMN in the presence of serum strongly depended on C5 cleavage, pointing to a direct interaction between complement and PMN. Strong cell surface expression of @entity3 receptors was detected on PMN, whereas NK cells completely lacked expression. Stimulation of PMN with @entity3 led to upregulation of activated complement receptor 3, resulting in enhanced complement receptor 3-dependent PMN- @entity1 against @entity0 cells. In conclusion, complement-optimized @entity2 Abs may constitute a promising strategy to improve @entity0 cell killing by enhancing the interaction between humoral and cellular effector functions in Ab-based @entity0 therapy.

title: A Complement-Optimized @entity2 Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against XXXX Cells.

answer: @entity0


abstract: OBJECTIVE: To study the effects of inhalation @entity5 (Enf) before aortic clamping on @entity1 in cardiac surgery with cardiopulmonary bypass (CPB). METHODS: hirty patents undergoing selective cardiac valve replacement were randomly allocated to three groups. Group I and group II inhaled 1.0 MAC and 0.5 MAC Enf before clamping aorta, respectively. Group III was the control group interval administration with @entity4 . RESULTS: Immediately upon aortic clamp release (T2), the value of CK-MB, @entity3 and SOD of all the groups was significantly increased, however,their concentration did not peak significantly until T3 and T4(10 and 30 min after clamp aorta release). The levels at 60 min (T5) and 24 hours (T6) aorta were lower than T4 but still higher than T(0). At T3 and T4, CK-MB levels in group I were significantly higher than those in II and III groups (P=0.0220, 0.0108 and 0.0202, 0.0295). At T6, the CK-MB level of group II was significantly higher than that of group III (P<0.0001). At T4 and T5, the @entity3 value of group I was higher than that of group II (P=0.0060 and 0.0364). Meanwhile, the SOD level in group I was also higher than that of group II and group III at the T4 point (P<0.0001 and 0.0084). There was a correlation between the CK-MB value and the aorta clamping time,correlation coefficient range being 0.55 - 0.81,(P<0.05). However, there was no correlation between the CK-MB and @entity3 , SOD. CONCLUSION: There is @entity0 reperfusion injury during cardiac surgery CPB with the increase of OFR production and elevation of the antioxidant reserve. Inhalation of large dose of @entity5 may result in increased @entity2 reperfusion injury manifested by elevated levels of myocardial enzymes and OFR production.

title: [Effects of @entity5 on XXXX during cardiac surgery with cardiopulmonary bypass].

answer: @entity1


abstract: Objective The standard treatment for submucosal @entity3 is esophagectomy or chemoradiotherapy (CRT). However, these treatment modalities could deteriorate the general condition and quality of life of the @entity0 who are intolerant to invasive therapy. It is therefore important and beneficial to develop less invasive treatment protocols for these @entity0 . Methods The study included 43 @entity0 who were clinically suspected of @entity3 but underwent endoscopic submucosal dissection (ESD) as a primary treatment, due to the @entity0 ' poor performance statuses and/or preferences for less invasive therapy. According to the pathological findings and @entity0 's general condition, whether the @entity0 underwent additional treatments or remained hospitalized without additional treatments was thereafter decided for each @entity0 . We retrospectively analyzed the outcomes of these @entity0 . Results Fifteen @entity0 underwent additional surgery, 11 @entity0 underwent CRT/radiation therapy (RT) and 17 @entity0 were followed without additional treatments. During the 3-year follow-up period, the relapse-free survival rates in the @entity0 who received or did not receive additional treatments were 88% and 64%, respectively (95% confidence interval, 0.45-0.76, p=0.04). The relapse-free and overall survival rates in the @entity0 with additional treatments were equivalent or superior to those described in previous reports of the standard treatments. Preceding ESD contributed to reduce the local relapse significantly to approximately 3.5% and additional CRT-related @entity2 . Conclusion Preceding ESD is very effective for the local control of @entity1 , and useful for histologically confirming the high-risk factors of relapse, such as >= submucosal layer 2 (SM2) invasion and @entity4 . ESD with additional therapy may be a promising strategy for optimizing the selection of therapy depending on the @entity0 's general condition.

title: Endoscopic Submucosal Dissection (ESD) with Additional Therapy for Superficial XXXX with Submucosal Invasion.

answer: @entity3


abstract: Assigning a @entity1 grade to @entity0 provides important prognostic information and guides optimal therapy. The present study was undertaken to grade @entity0 on aspirates by Robinson grading ( @entity2 ) and Scarff-Bloom-Richardson grading system (SBR). Histological grading was done according to Nottingham modification of Scarff-Bloom-Richardson method and the two cytological grading systems were compared. Fifty cases of @entity0 with preoperative cytologic diagnosis were assigned @entity1 grade. Histologic grading was done on corresponding mastectomy or partially resected specimens. Statistical analysis was performed; correlation between cytologic and histologic grading was established using Spearman correlation coefficient. Regression analysis was done to assess the significance of each cytological feature. Univariate analysis showed strong correlation (P < 0.01) for all features except dissociation. Multiple regression analysis of cytologic features revealed cell dissociation nucleoli and nuclear margin as the most influential features. A concordance of 72.5% between @entity2 (cyto) and SBR (cyto), 64% for @entity2 (cyto) and SBR (histo), 82% for SBR (cyto) and SBR (histo) was noted. There was a significant association (P < 0.001) between the grades assigned to cytologic and histologic specimens. Cytologic grade could be used to predict histologic grade as significant relationship exists between grades assigned to cytologic and histologic specimens.

title: Cytohistological correlation of grading in XXXX .

answer: @entity0


abstract: The authors discuss their successful preliminary experience with 36 cases of cervical spondylotic disease by performing facetal distraction using specially designed Goel cervical facet spacers. The clinical and radiological results of treatment are analyzed. The mechanism of action of the proposed spacers and the rationale for their use are evaluated. Between 2006 and February 2010, 36 @entity0 were treated using the proposed technique. Of these @entity0 , 18 had multilevel and 18 had single-level cervical @entity3 and/or @entity2 . The average follow-up period was 17 months with a minimum of 6 months. The Japanese Orthopaedic Association classification system, visual analog scale ( @entity4 and @entity3 ), and Odom criteria were used to monitor the clinical status of the @entity0 . The @entity0 were prospectively analyzed. The technique of surgery involved wide opening of the facet joints, denuding of articular cartilage, distraction of facets, and forced impaction of Goel cervical facet spacers into the articular cavity. Additionally, the interspinous process ligaments were resected, and corticocancellous bone graft from the iliac crest was placed and was stabilized over the adjoining laminae and facets after adequately preparing the host bone. Eighteen @entity0 underwent single-level, 6 @entity0 underwent 2-level, and 12 @entity0 underwent 3-level treatment. The alterations in the physical architecture of spine and canal dimensions were evaluated before and after the placement of intrafacet joint spacers and after at least 6 months of follow-up. All @entity0 had varying degrees of relief from symptoms of @entity1 , @entity3 , and @entity2 . Analysis of radiological features suggested that the distraction of facets with the spacers resulted in an increase in the intervertebral foraminal dimension (mean 2.2 mm), an increase in the height of the intervertebral disc space (range 0.4-1.2 mm), and an increase in the interspinous distance (mean 2.2 mm). The circumferential distraction resulted in reduction in the buckling of the posterior longitudinal ligament and ligamentum flavum. The procedure ultimately resulted in segmental bone fusion. No @entity0 worsened after treatment. There was no noticeable implant malfunction. During the follow-up period, all @entity0 had evidence of segmental bone fusion. No @entity0 underwent reexploration or further surgery of the neck. Distraction of the facets of the cervical vertebra can lead to remarkable and immediate stabilization-fixation of the spinal segment and increase in space for the spinal cord and roots. The procedure results in reversal of several pathological events related to spondylotic disease. The safe, firm, and secure stabilization at the fulcrum of cervical spinal movements provided a ground for segmental spinal arthrodesis. The immediate postoperative improvement and lasting recovery from symptoms suggest the validity of the procedure.

title: Facetal distraction as treatment for single- and multilevel cervical @entity3 and XXXX : a preliminary report.

answer: @entity2


abstract: The outcome of 30 proximal @entity4 and pathological lesions in 29 @entity0 treated with the Russell-Taylor reconstruction nail are reported. Four @entity0 had @entity2 involving both the femoral neck and shaft (segmental). Fifteen @entity0 had extensive comminuted @entity2 of the proximal femur and ten @entity0 underwent nailing because of @entity2 (one bilateral). In nineteen operations there were technical difficulties, nail insertion and proximal interlocking being the commonest. In the elderly there was a high post-operative complication rate. Three nails needed to be revised for failure of fixation. On review, all @entity0 under sixty years of age regained full mobility and returned to their pre-fracture level of activities. @entity0 with per-trochanteric @entity2 over the age of sixty had less favourable results. No @entity1 @entity0 returned to their prefracture mobility level. The Russell-Taylor reconstruction nail proved to be useful in the treatment of segmented and, in a lesser degree, @entity2 . However, the surgical technique is demanding and there is a high incidence of @entity3 in the @entity0 over the age of sixty.

title: The treatment of XXXX with the Russell-Taylor reconstruction nail.

answer: @entity4


abstract: BACKGROUND: We hypothesized that the cardiac time intervals reveal @entity5 in @entity0 with @entity4 and are strong predictors of @entity3 in the general population. METHODS AND RESULTS: In a large community-based population study, cardiac function was evaluated in 1915 @entity0 by using both conventional echocardiography and tissue Doppler imaging (TDI). The cardiac time intervals, including the isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET), were obtained by TDI M-mode through the mitral leaflet. IVCT/ET, IVRT/ET, and myocardial performance index [MPI=(IVRT+IVCT)/ET] were calculated. After multivariable adjustment for clinical variables the IVRT, IVRT/ET, and MPI, remained significantly impaired in @entity0 with @entity4 (n=826) compared with @entity0 without @entity4 (n=1082). Additionally, they displayed a significant dose-response relationship, between increasing severity of elevated blood pressure and increasing left ventricular mass index (P<0.001 for all). Further, during follow-up of a median of 10.7 years, 435 had an @entity3 ( @entity1 @entity6 , @entity7 , or @entity2 ). The IVRT/ET and MPI were powerful and independent predictors of future @entity3 , especially in @entity0 with known @entity4 . They provide prognostic information incremental to clinical variables from the Framingham Risk Score, the SCORE risk chart, and the European Society of @entity4 /European Society of Cardiology risk chart. CONCLUSION: The cardiac time intervals identify @entity6 in individuals with @entity4 , not only independent of conventional risk factors but also in @entity0 with a normal conventional echocardiographic examination. The IVRT/ET and MPI are independent predictors of future @entity3 especially in @entity0 with known @entity4 .

title: Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode: Association With @entity4 , Left Ventricular Geometry, and Future XXXX .

answer: @entity3


abstract: BACKGROUND: There is controversy over whether a lack of breastfeeding is related to @entity1 development. OBJECTIVE: We examined the effects of feeding different types of milk in late infancy on childhood growth. DESIGN: A cohort of 1112 term, singleton @entity0 (born in 1992) from the Avon Longitudinal Study of Parents and @entity0 , United Kingdom, were studied prospectively. Food records collected at 8 mo of age were used to define the following 5 mutually exclusive feeding groups on the basis of the type and amount of milk consumed: breast milk (BM), <600 mL formula milk/d (FMlow), >= 600 mL formula milk/d (FMhigh), <600 mL @entity2 milk/d (CMlow), and >= 600 mL @entity2 milk/d (CMhigh). Weight, height, and BMI were measured at 14 time points from birth to 10 y of age, and SD scores (SDSs) were calculated. Dietary energy and macronutrient intakes were available at 7 time points. RESULTS: CMhigh @entity0 were heavier than were BM @entity0 from 8 mo to 10 y of age with weight differences (after adjustment for maternal education, smoking, and parity) >= 0.27 SDSs and an average of 0.48 SDSs. The maximum weight difference was at 18 mo of age (0.70 SDS; 95% CI: 0.41, 1.00 SDS; P = <0.0001). CMhigh @entity0 were taller at some ages (25-43 mo; P < 0.01) and had greater BMI SDSs from >= 8 mo of age (at 9 y of age; P = 0.001). FMhigh @entity0 were heavier and taller than were BM @entity0 from 8 to 37 mo of age. There were marked dietary differences between milk groups at 8 mo of age, some of which persisted to 18 mo of age. Adjustments for current energy and protein intakes did not attenuate the growth differences observed. CONCLUSIONS: The feeding of high volumes of @entity2 milk in late infancy is associated with faster weight and height gain than is BM feeding. The feeding of bottle-fed @entity0 with high volumes of @entity2 milk in late infancy may have a persisting effect on body habitus through childhood.

title: Effects on childhood body habitus of feeding large volumes of XXXX or formula milk compared with breastfeeding in the latter part of infancy.

answer: @entity2


abstract: PURPOSE: @entity5 following a @entity4 procedure occurs in 5 to 20% of @entity0 . We examine the success of transvaginal urethrolysis in resolving @entity2 . MATERIALS AND METHODS: A retrospective chart review was performed on 39 @entity0 who had undergone transvaginal urethrolysis for @entity5 following an anti- @entity1 procedure. Preoperatively, a history was taken, and pelvic examination and either video urodynamics or cystoscopy were done. RESULTS: All 39 @entity0 complained of urge @entity1 , 13% had urinary retention, 51% had @entity3 and 36% voided to completion but had irritative voiding symptoms. Previous surgery included retropubic urethropexy in 41% of the cases, pubovaginal sling in 38% and bladder neck suspension in 21%. Mean length of followup after urethrolysis was 16 months. Of the 39 @entity0 33 (85%) had resolution of urge @entity1 but 5 still required occasional intermittent catheterization. The remaining 6 @entity0 had continued urge @entity1 . An augmentation procedure was performed in 4 @entity0 with improvement of symptoms. CONCLUSIONS: Our data support transvaginal urethrolysis for the treatment of iatrogenic @entity5 . It is a rapid, effective and minimally invasive technique that should be considered if @entity2 does not resolve spontaneously.

title: Transvaginal urethrolysis for @entity5 after anti- XXXX surgery.

answer: @entity1


abstract: PURPOSE: Current practices applied to @entity0 pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles.   The purpose of this work was to evaluate and optimize blood microsampling techniques coupled with dried blood spot (DBS) and LC-MS/MS analysis to generate reliable PK data in @entity0 .   In addition, the feasibility of cross-over designs was assessed and recommendations are presented. METHODS: The work describes a comprehensive evaluation of five blood microsampling techniques (tail clip, tail vein with needle hub, submandibular, retro-orbital, and @entity1 ) in CD-1 @entity0 .   The feasibility of blood sampling was evaluated based on animal observations, ease of @entity1 , and ability to collect serial samples.   @entity2 , @entity3 and @entity4 were used as test compounds and were dosed either orally or intravenously, followed by DBS collection and LC-MS/MS analysis to compare PK with various @entity1 methods. RESULTS: Submandibular and retro-orbital methods that required non-serial blood collections did not allow for inter-animal variability assessments and resulted in poorly described absorption and distribution kinetics.   The submandibular and tail vein with needle-hub methods were the least favorable from a technical feasibility perspective.   Serial @entity1 was possible with cannulated animals or @entity1 in non-cannulated animals. CONCLUSIONS:    Of the methods that allowed serial sampling, the saphenous method when executed as described in this report, was most practical, reproducible and provided for assessment of inter-animal variability.   It enabled the collection of complete exposure profiles from a single @entity0 and the conduct of an intravenous/oral cross-over study design.   This methodology can be used routinely, it promotes the 3Rs principles by achieving reductions in the number of animals used, decreased restraints and animal stress, and improved the quality of data obtained in @entity0 PK studies.  This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual XXXX .

answer: @entity0


abstract: We have demonstrated previously that protein kinase Calpha (PKCalpha) plays a key role in regulating phospholipase D (PLD) activation by @entity6 and the @entity11 @entity4 in Madin-Darby @entity1 kidney (MDCK-D1) cells. In the current work, we investigated PLD activation in MDCK-D1 cells triggered by the adrenergic receptor agonist @entity5 and its mechanism of activation. @entity5 , acting through the alpha1-adrenergic receptor subtype, promoted transient translocation of PKCalpha and more prolonged translocation of PKCepsilon to the membrane fraction, indicating activation of these two isoforms. In addition, @entity5 promoted activation of PLD, as shown by a sustained accumulation of @entity12 . All of these events were blocked by pretreatment of cells with the alpha1-adrenergic antagonist @entity8 . D609, an inhibitor of @entity7 hydrolysis, blocked translocation of PKCalpha and PKCepsilon but did not inhibit PLD activation. Unlike results with @entity9 , or with the P2 purinergic receptor agonist @entity3 , @entity5 -stimulated PLD activity was not inhibited in MDCK-D1 cells in which PKCalpha expression is attenuated by an antisense cDNA construct or in cells in which PKC activity was inhibited by 1 microM GF 109203X. However, PLD activation by @entity5 was abolished by concomitant incubation of cells with the @entity2 chelator @entity10 . These data, together with previous results, are consistent with the hypothesis that in MDCK-D1 cells, @entity5 acting on alpha1-adrenergic receptors, promotes a rapid increase in cytosolic @entity0 that promotes activation of PLD through an as-yet poorly defined mechanism. The data demonstrate that different types of G protein-linked receptors that activate PLD can mediate this activation in either a PKC activation-dependent or -independent manner within a single cell type.

title: Stimulation of phospholipase D via alpha1-adrenergic receptors in Madin-Darby XXXX kidney cells is independent of PKCalpha and -epsilon activation.

answer: @entity1


abstract: BACKGROUND: @entity7 are caused by obligate intracellular bacteria belonging to the spotted fever group (SFG) rickettsiae. Although Spotted @entity0 is prevalent in the Middle East, no reports for the presence of tick-borne pathogens are available or any studies on the epidemiology of this disease in the West Bank. We aimed to identify the circulating hard tick vectors and genetically characterize SFG @entity10 species in ixodid ticks from the West Bank-Palestinian territories. METHODOLOGY/PRINCIPAL FINDINGS: A total of 1,123 ixodid ticks belonging to eight species (Haemaphysalis parva, Haemaphysalis adleri, @entity2 turanicus, @entity2 , @entity2 bursa, Hyalomma dromedarii, Hyalomma aegyptium and Hyalomma impeltatum) were collected from @entity5 , @entity4 , @entity8 , @entity1 , a wolf, a @entity6 and a tortoise in different localities throughout the West Bank during the period of January-April, 2014. A total of 867 ticks were screened for the presence of rickettsiae by PCR targeting a partial sequence of the ompA gene followed by sequence analysis. Two additional genes, 17 kDa and 16SrRNA were also targeted for further characterization of the detected @entity10 species. Rickettsial DNA was detected in 148 out of the 867 (17%) tested ticks. The infection rates in Rh. turanicus, Rh. sanguineus, H. adleri, H. parva, H. dromedarii, and H. impeltatum ticks were 41.7, 11.6, 16.7, 16.2, 11.8 and 20%, respectively. None of the ticks, belonging to the species Rh. bursa and H. aegyptium, were infected. Four SFG rickettsiae were identified: @entity10 massiliae, @entity10 africae, Candidatus @entity10 barbariae and Candidatus @entity10 goldwasserii. SIGNIFICANCE: The results of this study demonstrate the geographic distribution of SFG rickettsiae and clearly indicate the presence of at least four of them in collected ticks. Palestinian clinicians should be aware of emerging @entity7 in the West Bank, particularly @entity3 due to @entity10 and @entity9 .

title: Molecular Detection and Identification of Spotted XXXX Group Rickettsiae in Ticks Collected from the West Bank, Palestinian Territories.

answer: @entity0


abstract: OBJECTIVE: To investigate the information provision concerning possible benefits and harms of short-course preoperative radiotherapy (PRT) at pre-treatment consultations between radiation oncologists and @entity1 @entity0 . DESIGN: Observational study. METHOD: We audiotaped the consultations between 17 radiation oncologists and 81 @entity0 with primary @entity1 who were eligible for PRT. The recordings were transcribed and analysed descriptively. RESULTS: A median of seven benefits/harms of PRT were addressed at each consultation (range, 2-13). This number differed both in and between individual oncologists and was not consistently associated with the @entity0 's characteristics. A total of 30 different treatment outcomes was addressed. The effect of PRT on local control was addressed in all consultations, and the effect on survival in 16%. The most important adverse effects according to the literature are @entity2 and @entity3 . These were addressed in 82% and 85% of consultations, respectively; sexual problems were discussed significantly more often with male than female @entity0 . Four out of five @entity0 did not initiate discussion on potential benefits/harms. CONCLUSION: There was a considerable variation in the number and nature of benefits and harms of PRT that were discussed prior to treatment. This variation indicates a lack of clarity concerning which benefits/harms of radiotherapy should be discussed with newly-diagnosed @entity0 . This suboptimal provision of information to @entity0 hampers the process of shared decision making, in which the decision is based on each individual @entity0 's weighing of benefits and harms. We do not believe our findings to be specific for PRT, but expect to find similar variation in provision of information with regard to other treatment decisions.

title: [Decision-making in preoperative radiotherapy in XXXX : variation in provision of information].

answer: @entity1


abstract: UNASSIGNED: Abusive @entity4 includes any @entity2 inflicted to a @entity0 's head and body. It is often characterized by, but not  limited to, the repetitive acceleration-deceleration forces with or without blunt head impact. It has a mortality rate of 30%, and 80% of survivors experience permanent @entity1 . In this case series, we hypothesize that bedside ultrasonography can be useful in the identification of @entity5 that are consistent with abusive @entity4 . Ocular manifestations of abusive @entity4 are identified by dilated ophthalmic examination showing @entity7 that are too numerous to count, multilayered, and extending to the periphery. @entity8 , splitting of the retinal layers with or without blood accumulating in the intervening space, is exclusive for abusive @entity4 in @entity0 without a history of significant cerebral @entity2 . Direct visualization of intraocular structures is difficult when the eyelids are swollen shut or when dilatation must be delayed. We present a series of 11 @entity0 with @entity6 who underwent ophthalmic point-of-care ultrasonography that revealed @entity8 on average 60 hours earlier than direct ophthalmic visualization. Dilated ophthalmic examinations and autopsy reports confirmed @entity8 and other forms of @entity7 that were too numerous to count, multilayered, and extending to the periphery in all 11 @entity0 . One @entity0 did not have a dilated ophthalmic examination; however, @entity8 and @entity7 were confirmed on autopsy. Ocular point-of-care ultrasonography is a promising tool to investigate abusive @entity4 through the identification of @entity8 and @entity7 when @entity3 and direct ophthalmic examination is delayed.

title: The Use of Ophthalmic Ultrasonography to Identify @entity5 Associated With Abusive XXXX .

answer: @entity4


abstract: UNASSIGNED: Spontaneous @entity1 (SRAD) is a rare disease entity. The diagnosis is usually delayed because clinical presentation is non-specific. We report three cases of symptomatic SRAD complicated by @entity5 which occurred in previously healthy middle-aged male @entity0 . They visited the hospital due to acute @entity4 . They had no specific underlying disease or @entity2 history. The laboratory tests and physical examination were normal. They were not suspected of having SRAD initially, but computed tomography (CT) revealed @entity1 with distal hypoperfusion leading to @entity5 . They were treated conservatively with anticoagulation and/or antiplatelets for 6 months. They had a 6-month regular follow-up with CT, where resolution was confirmed in one @entity0 and all @entity0 remained asymptomatic. These cases emphasize the importance of clinical suspicion of SRAD in previously healthy @entity0 who complain of @entity3 without specific findings on initial investigation.

title: Spontaneous Renal Artery Dissection Complicated by XXXX : Three Case Reports.

answer: @entity5


abstract: UNASSIGNED: @entity5 and subsequent @entity4 ( @entity4 ) increase the risk of @entity7 in the newborn by 40 fold. The latter, in turn, increases the risk of @entity2 and @entity3 . This study seeks to determine the effectiveness of broccoli sprouts (BrSp), a rich source of the isothiocyanate @entity8 , as a neuroprotectant in a @entity0 model of @entity5 and @entity4 . @entity5 and @entity4 was induced by bilateral uterine artery ligation (BUAL) on day E20 of gestation. Dams were fed standard chow or chow supplemented with 200mg of dried BrSp from E15 - postnatal day 14 (PD14). Controls received Sham surgery and the same dietary regime. Pups underwent neurologic reflex testing and open field testing, following which they were euthanized and their brains frozen for neuropathologic assessment. Compared to Sham, @entity4 pups were delayed in attaining early reflexes and performed worse in the open field, both of which were significantly improved by maternal supplementation of BrSp (p<0.05). Neuropathology revealed diminished white matter, @entity6 , astrogliosis and reduction in hippocampal neurons in @entity4 animals compared to Sham, whereas broccoli sprout supplementation improved outcome in all histological assessments (p<0.05). Maternal dietary supplementation with BrSp prevented the detrimental neurocognitive and neuropathologic effects of chronic intrauterine @entity1 . These findings suggest a novel approach for prevention of @entity2 and/or @entity3 associated with @entity5 .

title: Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn XXXX following @entity5 .

answer: @entity0


abstract: INTRODUCTION: @entity2 is a neurodegenerative condition involving @entity1 . It is important to know why all these different deficits co-occur in the affected @entity0 . This paper aims to clarify whether these comorbid deficits result from the selective impairment of a computational primitive, namely, a context-sensitive computational ability according to Chomsky's Hierarchy (a well-established research tool in comparative neuroscience). @entity0 AND METHODS: A total of 15 medicated subjects with @entity2 and 15 controls were selected. They were matched in age and education. A battery of tasks was designed to test 3 different domains (motor capacities, cognition, and language) and 2 different computational abilities (context-free and context-sensitive operations). RESULTS: Significant differences between groups were observed only regarding the linguistic task involving context-sensitive computations (correferences). CONCLUSIONS: The observed deficits in our @entity0 with @entity2 cannot be explained in terms of the selective impairment of one only unspecific, low-level computational process. At the same time, differences between @entity0 and controls are expected to be greater if the former are not medicated. Moreover, we should pursue in the search of (this kind of) computational primitives than can be selectively impaired in @entity0 with @entity2 , because they may help to achieve an earlier diagnosis of this condition.

title: A core deficit in XXXX ?

answer: @entity2


abstract: CONTEXT: Pragmatic trials lack the relatively tight quality control of traditional efficacy studies and hence may pose added analytic challenges owing to the practical realities faced in carrying them out. CASE DESCRIPTION: STOP @entity1 is a cluster randomized trial testing the effectiveness of automated, electronic medical record (EMR)-driven strategies to raise @entity1 ( @entity1 ) screening rates in safety net clinics. Screen-eligible @entity0 were accrued during year 1 and followed for 12 months (measurement window) to assess completion of a fecal screening test. Control clinics implemented the intervention in year 2. IMPLEMENTATION CHALLENGES/ANALYTIC ISSUES: Due to limitations on how we could build the intervention tools, the overlap of the year 1 measurement windows with year 2 intervention rollout posed a potential for contamination of the primary outcome for control @entity0 . In addition, a variety of factors led to a lack of synchronization of the measurement windows with actual intervention delivery. In both cases, the net impact of these factors would be to diminish the estimated impact of the intervention. PROPOSED SOLUTIONS: We dealt with the overlap issue by delaying the start of intervention rollout to control clinics in year 2 by 6 months and by truncating the measurement windows for intervention and control @entity0 at this point. In addition we formulated three sensitivity analyses to help address the issue of asynchronization. CONCLUSION: This case study might help other investigators facing similar challenges think about such issues and the pros and cons of various strategies for dealing with them.

title: Analytic Challenges Arising from the STOP XXXX Trial: Pragmatic Solutions for Pragmatic Problems.

answer: @entity1


abstract: Aim. The aim of this study was to evaluate the role of the @entity4 ( @entity5 ) @entity2 gene polymorphism in clinical parameters and the risk for development of @entity1 . Material and Methods. The study consisted of 430 @entity0 with @entity1 (mean age: 53.2    10.11) and 430 healthy subjects (mean age: 50.31    18.21). Analysis of the gene polymorphisms was performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP). The odds ratios (ORs) and 95% confidence intervals (CIs) for each genotype and allele were calculated. Results. The results obtained indicate that the genotype @entity3 / @entity3 is associated with an increased risk of @entity1 (OR 5.01; 95% CI 3.37-7.43; p < 0.0001). Association of @entity4 polymorphism with histological grading showed increased @entity2 @entity3 / @entity3 (OR = 6.96; 95% CI 3.41-14.21; p < 0.0001) genotype in grading 1 as well as @entity3 allele overrepresentation (OR = 4.98; 95% CI 3.37-7.40; p < 0.0001) in G1 ovarian @entity0 . Finally, with clinical FIGO staging under evaluation, an increase in @entity2 @entity3 / @entity3 homozygote frequencies in staging I and @entity3 allele frequencies in SI were observed. Conclusion. On the basis of these results, we conclude that @entity2 gene polymorphism @entity4 may be associated with an increased risk of @entity1 .

title: An Association between Single Nucleotide Polymorphisms of @entity4 XXXX Gene and @entity1 in Polish @entity0 .

answer: @entity2


abstract: Angiogenesis is important in the pathogenesis of @entity1 and correlates with clinical outcome in certain @entity1 . Recent advances in staining techniques have raised doubts about the prognostic value of @entity3 in muscle-invasive @entity2 , for which relatively few predictors for survival exist. Twenty-one radical cystectomy specimens from @entity0 with stage pT2-3NOMO transitional cell @entity1 were examined by staining with @entity4 and @entity5 (H_E). Factor VIII-related antigen (FVIII RAG) which is specific for vascular endothelium, and MOVAT which highlights large vessels. Angiogenesis, estimated by microvessel density, and presence of @entity3 were then correlated with survival in the follow-up period which ranged from 3 to 141 months. Six of 21 @entity0 survived disease-free with follow-up ranging from 47 to 141 months. Twelve @entity0 had lower microvessel density than 178/mm2 and five of these survived, whereas only one of nine @entity0 having higher microvessel density survived. Twelve of 21 @entity0 had @entity3 and three survived whereas three of nine @entity0 without @entity3 survived. There was no correlation found between @entity3 and survival in this study. Analysis by Kaplan-Meir survival curves demonstrated trends which were not statistically significant between high and low angiogenesis groups. The preliminary data suggest that further assessment of the prognostic role of angiogenesis and @entity3 in muscle-invasive @entity2 is indicated.

title: Prognostic value of angiogenesis and @entity3 in muscle-invasive XXXX .

answer: @entity2


abstract: PURPOSE: We aimed to develop a @entity6 surrogate marker for early prediction of late @entity4 in @entity0 receiving brain @entity5 ( @entity5 ). METHODS AND MATERIALS: Twenty-seven @entity0 (17 males and 10 females, 31-80 years of age) were enrolled in an institutional review board-approved prospective longitudinal study. @entity0 received diagnoses of @entity3 or @entity2 and were treated by (3D) conformal or intensity-modulated @entity5 with a median dose of 54 Gy (50.4-59.4 Gy in 1.8-Gy fractions). Six dynamic-contrast enhanced MRI scans were performed from pre- @entity5 to 18-month post- @entity5 , and quantified for vascular parameters related to blood-brain barrier permeability, K(trans), and the fraction of blood plasma volume, Vp. The temporal changes in the means of hippocampal transfer constant K(trans) and Vp after starting @entity5 were modeled by integrating the dose effects with age, sex, hippocampal laterality, and presence of @entity2 or @entity1 near a hippocampus. Finally, the early vascular dose response in hippocampi was correlated with @entity4 at 6 and 18 months post- @entity5 . RESULTS: The mean K(trans) Increased significantly from pre- @entity5 to 1-month post- @entity5 (P<.0004), which significantly depended on sex (P<.0007) and age (P<.00004), with the dose response more pronounced in older females. Also, the vascular dose response in the left hippocampus of females correlated significantly with changes in memory function at 6 (r=-0.95, P<.0006) and 18-months (r=-0.88, @entity7 ) post- @entity5 . CONCLUSIONS: The early hippocampal vascular dose response could be a predictor of late @entity4 . A personalized hippocampus sparing strategy may be considered in the future.

title: A Radiation-Induced XXXX Surrogate Marker Predicts Late @entity4 .

answer: @entity6


abstract: OBJECTIVE: To determine the incidence and outcome of @entity2 encountered unexpectedly during gastric bariatric operations. DESIGN: A cohort study. SETTING: A tertiary care center. @entity0 : One hundred twenty-five @entity0 in whom @entity2 was discovered during gastric bariatric operations. @entity2 may have been caused by severe @entity1 in 93 (74%) of the @entity0 . INTERVENTIONS: A questionnaire survey of bariatric surgeons worldwide, including one of us (R.E.B.). RESULTS: One hundred twenty-six (52%) of the 243 surgeons responded to the survey. Planned bariatric operations were performed in 91 (73%) of the cases. Seventeen (14%) of the remaining cases were closed after the discovery of @entity2 . There were no intraoperative deaths. However, the perioperative mortality rate was 4% and there were 7 late deaths, 6 due to complications of @entity3 . Eleven other @entity0 are described as alive with progressive @entity3 . The remaining 50 @entity0 are "alive and well." The survey also included opinion questions. Regarding the appropriate operation to perform after discovering @entity2 , 40% replied "perform liver biopsy only and close"; the remaining 60% would perform a bariatric procedure. Regarding bariatric operations that can be safely performed in @entity0 with @entity2 , 59% would perform banded gastroplasty, 39% would perform standard Roux-en-Y gastric bypass, 5% would perform biliopancreatic bypass, and 27% would perform none of the above. CONCLUSION: Although operative mortality is higher in cirrhotic vs other bariatric @entity0 , most surveyed surgeons believe that gastric restrictive operations can be performed safely in this group of @entity0 .

title: Unsuspected @entity2 discovered during elective XXXX operations.

answer: @entity1


abstract: High-sensitivity @entity6 ( @entity6 ), proposed as a new coronary risk marker, may reflect either an acute phase reaction or the level of chronic @entity1 . Thus, @entity6 may be less predictive of long-term outcomes when measured after @entity4 ( @entity7 ) than after unstable @entity5 (UAP) or @entity8 ( @entity8 ). A total of 1,360 @entity0 with severe @entity3 (>/=1 stenosis >/=70%) had @entity6 levels obtained at angiography. Presenting diagnoses were @entity8 (n = 599), UAP (n = 442), or @entity7 (n = 319). During follow-up (mean 2.8 years), @entity2 or nonfatal @entity7 ( @entity7 ) occurred in 19.5%, 16.1%, and 17.2% (p = NS) with @entity8 , UAP, and @entity7 , respectively. Corresponding median @entity6 levels were 1.31, 1.27, and 2.50 mg/dl (p <0.001). For the overall cohort, increasing age, low ejection fraction, revascularization, and elevated @entity6 were the strongest of 6 independent predictors for @entity7 . Among those presenting with @entity8 , @entity6 levels above the first tertile were associated with an adjusted hazard ratio of 1.8 (95% confidence interval [CI] 1.2 to 2.8, p <0.009) for @entity7 . After UAP, the hazard ratio was 2.7 (95% CI 1.4 to 5.0, p <0.002). However, when measured during hospitalization for @entity7 , @entity6 was not predictive of long-term outcome (hazard ratio 1.0 [95 % CI 0.5 to 1.7] p = 0.86). In conclusion, predischarge @entity6 levels are higher after @entity7 than after UAP or @entity8 . However, whereas @entity6 is strongly predictive of long-term @entity7 for @entity0 presenting with @entity8 or UAP, it is not predictive shortly after @entity7 , suggesting that measurements should be delayed until the acute phase reaction is over and levels have returned to baseline.

title: Usefulness of high-sensitivity @entity6 in predicting long-term risk of XXXX or @entity4 in @entity0 with unstable or @entity8 or @entity4 .

answer: @entity2


abstract: BACKGROUND: @entity4 is an autosomal dominantly inherited connective tissue disorder characterised by ocular, orofacial, skeletal and auditory features. The estimated prevalence is 1:10,000. MATERIAL AND METHODS: We present a @entity0 with the salient features of @entity4 . Based on a literature search on Medline, we present an overview of this disorder. RESULTS: The @entity0 presented at birth with Pierre Robin sequence and bilateral exophtalmus. Serial ophthalmological investigations have revealed a non-progressive @entity3 of high degree and @entity2 . From the age of three, she had joint @entity5 and @entity1 . Her intelligence is normal, but she requires speech therapy because of problems with articulation. INTERPRETATION: Recent research has provided a better understanding of the molecular genetic background of this condition. According to mutations in three genes encoding type II- and/or type XI-collagen, @entity4 can be subclassified into type 1, 2 and 3, but there is a considerable clinical overlap in symptoms. @entity0 with mild symptoms may be undiagnosed. Once the diagnosis is established, a coordinated multidisciplinary follow-up approach is recommended.

title: [ XXXX --an underdiagnosed condition?].

answer: @entity4


abstract: UNASSIGNED: @entity7 has been shown to promote hair growth in several recent studies. However, its effects on @entity0 hair follicles and its mechanisms of action have not been sufficiently elucidated. This study aimed to investigate the hair growth-promoting effects of red @entity7 extract (RGE) and its ginsenosides. The proliferative activities of cultured @entity0 hair follicles treated with RGE and ginsenoside- @entity3 were assessed using Ki-67 immunostaining. Their effects on isolated @entity0 @entity5 cells (hDPCs) were evaluated using cytotoxicity assays, immunoblot analysis of signaling proteins, and the determination of associated growth factors. We examined the ability of RGE and ginsenosides to protect hair matrix keratinocyte proliferation against dihydrotestosterone (DHT)-induced @entity4 and their effects on the expression of @entity8 . The in vivo hair growth-promoting effect of RGE was also investigated in C57BL/6 @entity1 . Both RGE and ginsenoside- @entity3 enhanced the proliferation of hair matrix keratinocytes. hDPCs treated with RGE or ginsenoside- @entity3 exhibited substantial cell proliferation and the associated phosphorylation of @entity6 and @entity2 . Moreover, RGE, ginsenoside- @entity3 , and ginsenoside-Rg3 abrogated the DHT-induced @entity4 of hair matrix keratinocyte proliferation and the DHT-induced upregulation of the mRNA expression of @entity8 in hDPCs. @entity1 experiments revealed that the subcutaneous injection of 3% RGE resulted in more rapid hair growth than the negative control. In conclusion, RGE and its ginsenosides may enhance hDPC proliferation, activate @entity6 and @entity2 signaling pathways in hDPCs, upregulate hair matrix keratinocyte proliferation, and inhibit the DHT-induced @entity8 transcription. These results suggest that red @entity7 may promote hair growth in @entity0 .

title: Red @entity7 Extract Promotes the Hair Growth in Cultured XXXX Hair Follicles.

answer: @entity0


abstract: BACKGROUND: Low concentrations of inhaled anesthetics present in the early postoperative period can increase @entity3 sensitivity. Changes in @entity3 threshold associated with inhaled anesthetics have been reported in male @entity1 , @entity2 , and @entity0 . METHODS: The authors compared the @entity3 -enhancing effects of @entity6 in male and female @entity1 in response to a thermal stimulus and studied the consequences of hormonal manipulation. RESULTS: @entity6 produced a larger increase in @entity3 sensitivity in female @entity1 . Both castration and oophorectomy resulted in an increase in baseline @entity3 sensitivity and potentiated @entity3 enhancement by @entity6 . At stages of the estrus cycle when @entity4 was low, female @entity1 showed greater @entity3 enhancement from @entity6 than at high @entity4 stages. Treatment with exogenous @entity4 reduced @entity6 -induced @entity3 sensitivity. Exogenous @entity5 treatment had a similar effect, which did not occur when enzymatic conversion to @entity4 was prevented. CONCLUSIONS: Because both @entity4 and @entity5 reduce the pronociceptive action of @entity6 , intact females may exhibit a larger increase in @entity3 sensitivity because of their cyclical @entity4 levels. @entity5 is effective in the male because of conversion to @entity4 . Enhanced @entity3 sensitivity is clearly undesirable in the postoperative setting. If these findings also apply to @entity0 , the menstrual cycle may be an important factor in determining @entity3 levels after emergence from general anesthesia.

title: Pronociceptive actions of @entity6 : a protective role for XXXX .

answer: @entity4


abstract: The @entity3 (FA) is a crosslinking agent that reacts with cellular macromolecules such as proteins, nucleic acids and molecules with low molecular weight such as @entity7 , and it has been linked to inflammatory processes and oxidative stress. This study aimed to analyze the oxidative effects on pulmonary inflammatory response in Fischer @entity0 exposed to different concentrations of FA. Twenty-eight Fischer @entity0 were divided into 4 groups (N  =  7). The control group (CG) was exposed to ambient air and three groups were exposed to different concentrations of FA: 1% (FA1%), 5% (FA5%) and 10% (FA10%). In the Bronchoalveolar Lavage Fluid (BALF), the exposure to a concentration of 10% promoted the increase of inflammatory cells compared to CG. There was also an increase of macrophages and lymphocytes in FA10% and lymphocytes in FA5% compared to CG. The activity of @entity5 oxidase in the blood had been higher in FA5% and FA10% compared to CG. The activity of @entity2 dismutase enzyme (SOD) had an increase in FA5% and the activity of the catalase enzyme (CAT) showed an increase in FA1% compared to CG. As for the @entity6 system, there was an increase in total @entity6 (tGSH), @entity6 ( @entity8 ) and @entity11 ( @entity11 ) in FA5% compared to CG. The reduced/oxidized @entity6 ratio ( @entity8 / @entity11 ) had a decrease in FA5% compared to CG. There was an increase in lipid peroxidation compared to all groups and the protein @entity9 formation in FA10% compared to CG. We also observed an increase in @entity4 and @entity12 chemokines in the treatment groups compared to CG and in serum there was an increase in @entity4 , @entity10 and @entity12 compared to CG. Our results point out to the potential of @entity3 in promoting @entity1 by increasing the inflammatory process as well as by the redox imbalance.

title: Oxidative effects on lung inflammatory response in @entity0 exposed to different concentrations of XXXX .

answer: @entity3


abstract: BACKGROUND: Spasticity arises from hyperexcitability of the neural stretch reflex arc secondary to injury of the corticospinal tract. In response to injury, the density of glutamatergic inputs from afferent 1A fibers to motor neurons increases dramatically and adaptive changes occur in the morphology of microglia cells in the spinal cord. SUMMARY: Involvement of the endocannabinoid system in pathophysiological mechanisms responsible for @entity4 has been demonstrated in animal models of @entity0 . Stimulation of cannabinoid (CB)1 receptors reduces the hyperglutamatergic drive from sensory afferents to spinal cord motor neurons and blocks the synaptic effects of activated microglia and pro-inflammatory mediators (e.g. @entity3 ) on glutamatergic transmission. Enhancing corticospinal tract excitability through intermittent theta burst stimulation inhibits the stretch reflex and @entity4 by promoting long-term potentiation, a form of synaptic plasticity that requires stimulation of @entity6 receptors. Evidence indicates that the antispasticity effects of @entity5 :CBD oromucosal spray (Sativex  ) are associated with enhanced cortical long-term potentiation. Key Messages: Glutamatergic and GABAergic pathways are involved in the regulation of muscle tone. @entity6 receptors, which are associated with movement, postural control, and @entity1 and sensory perception, influence glutamatergic pathways. @entity5 :CBD oromucosal spray was shown to reverse motor cortex plasticity from long-term @entity2 through long-term potentiation of synaptic transmission, thereby restoring, at least in part, effective corticospinal inputs to spinal circuits.    2014 S. Karger AG, Basel.

title: Advances in the management of @entity0 XXXX : @entity0 @entity4 nervous pathways.

answer: @entity4


abstract: Electrocardiographic repolarization parameters are potential markers of arrhythmogenic risk and have not been evaluated in @entity6 . The aim of this report was to investigate their associations with LV systolic function assessed by two-dimensional echocardiography. In a cross-sectional study involving 738 adult outpatients in the chronic phase of @entity6 , maximal QTc and T wave peak-to-end (TpTe) intervals, and @entity4 , QTapex (QTa), IT and TpTe interval dispersions, and variation coefficients were measured and calculated from 12-lead standard ECGs. Clinical, radiological, ECG, and echocardiographic data were recorded. In bivariate statistical analysis, all repolarization parameters were significantly increased in @entity0 with moderate or severe LV @entity1 , and these @entity0 showed more clinical, radiologic, and ECG abnormalities. Receiver operating characteristic curve analysis demonstrated that isolatedly QTd had the best predictive performance for @entity2 , with an 80% specificity and 67% sensitivity for values >60 ms in the subgroup of chagasic @entity0 with abnormal ECGs and no @entity3 . Multivariate logistic regression selected, as the best predictive model for @entity2 in this subgroup of @entity0 , the presence of @entity5 on chest X ray (OR 14.06, 95% CI, 5.54-35.71), QTd >60 ms (OR 9.35, 95% CI, 4.01-21.81), male gender (OR 7.70, 95% CI, 2.98-19.91) and the presence of frequent @entity7 ( @entity7 ) on ECG (OR 4.06, 95% CI, 1.65-9.97). This model showed 90% specificity and 71% sensitivity. In conclusion, QTd was associated to LV systolic function and could be used to predict @entity8 in chronic @entity6 . The presence of @entity5 , frequent @entity7 , and male sex refined LV function stratification in these @entity0 .

title: Electrocardiographic ventricular repolarization parameters in chronic XXXX as predictors of asymptomatic left ventricular systolic dysfunction.

answer: @entity6


abstract: A 49-year-old @entity0 was admitted with @entity8 , dyspnoea, pretibial @entity1 and decreased daily urination. Seven years ago she was treated with @entity4 , @entity10 , @entity16 and @entity12 , alternating with @entity14 , @entity11 , @entity15 and @entity3 and 80 Gy abdominal radiotherapy for @entity6 . Two years later, malignant @entity2 was diagnosed. Angiotensin-2 antagonist and beta-blocker treatment was given. After increased serum @entity7 levels were determined, renal angiography was performed and @entity13 in the right side was observed. She was admitted to our clinic with @entity9 , and @entity5 was diagnosed. Balloon angioplasty and stent implantation was performed to the right renal artery. After a polyuric period, serum @entity7 reduced to near normal levels. Angiotensin-2 antagonist treatment worsened the course in this @entity0 . @entity0 with resistant @entity2 occurring years after abdominal radiotherapy should be evaluated for @entity13 .

title: XXXX after abdominal radiotherapy for @entity6 .

answer: @entity13


abstract: OBJECTIVE: To compare @entity3 gene expression between @entity0 osteoarthritic and healthy cartilage and to examine whether expression is regulated by the promoter DNA methylation of the gene. METHODS: @entity0 cartilage samples were collected from @entity0 undergoing total hip/knee joint replacement surgery due to @entity2 ( @entity2 ), and from @entity0 with hip @entity1 as controls. DNA/RNA was extracted from the cartilage tissues. Real-time quantitative PCR was performed to measure gene expression, and Sequenom EpiTyper was used to assay DNA methylation. Mann-Whitney test was used to compare the methylation and expression levels between @entity2 cases and controls. Spearman rank correlation coefficient was calculated to examine the association between the methylation and gene expression. RESULTS: A total of 58 @entity0 with @entity2 (36 @entity0 , 22 @entity0 ; mean age 64    9 yrs) and 55 controls (43 @entity0 , 12 @entity0 ; mean age 79    10 yrs) were studied. @entity3 expression was on average 83% higher in @entity2 cartilage than in controls (p = 0.0005). No difference was observed for DNA methylation levels in the @entity3 promoter region between @entity2 cases and controls. No correlation was found between @entity3 expression and promoter DNA methylation. CONCLUSION: Our study demonstrates that @entity3 is significantly overexpressed in @entity2 . This overexpression cannot be explained by DNA methylation in the promoter region. The results suggest that the transforming growth factor-b/ @entity3 pathway may be overactivated in @entity2 cartilage and has potential in developing targeted therapies for @entity2 .

title: @entity3 Is Upregulated in XXXX Osteoarthritic Cartilage Independent of the Promoter DNA Methylation.

answer: @entity0


abstract: INTRODUCTION AND HYPOTHESIS: The aim of the study was to develop a Polish version of the @entity3 /Urinary Incontinence Sexual Questionnaire (PISQ) to evaluate sexual function in @entity0 with stress @entity1 (SUI) and pelvic organ prolapse (POP) versus a control group. METHODS: Before the validation study, a pilot study of the Polish version of the PISQ was performed in 22 @entity0 with @entity2 . The respondents completed the questionnaire at recruitment and 2  weeks later. Test-retest reliability and internal consistency were determined. The validation study was performed in 249 sexually active @entity0 (123 with urodynamic SUI and POP; 126 healthy controls). The study group reported @entity1 ( @entity1 ) at the urogynecological ambulatory clinic, where they underwent urogynecological and urodynamic examinations. All @entity0 completed the questionnaire. PISQ results from both groups were compared and correlated with those of the King's Health Questionnaire (KHQ) and @entity0 age. RESULTS: Test-retest reliability was good according to Pearson's correlation coefficient (r   =   0.89, p   <   0.001). PISQ had high internal consistency (Cronbach's a   =   0.878). The total PISQ score was significantly lower in the study group compared with the controls (83.6        14.9 vs 95.7        10.3, p   <   0.001), as were scores for individual domains: Behavioral/Emotive, Physical, Partner-Related (33.9        10.2 vs 39.8        7.8, 31.7        6.9 vs 37.1        2.8, and 18.0        3.1 vs 19.4        2.6 respectively; p   <   0.001), confirming the lower quality of sexual function in @entity0 with SUI and POP. A correlation between PISQ and KHQ scores and @entity0 age was confirmed. CONCLUSIONS: The Polish version of the PISQ is a reliable tool for evaluating sexual function in @entity0 with POP and @entity1 .

title: Validation of the Polish version of the XXXX /Urinary Incontinence Sexual Questionnaire.

answer: @entity3


abstract: PURPOSE: In primary treatment of @entity1 ( @entity1 ) in situ fixation reliably prevents slip progression. The aim of this study was to examine the long-term outcome of @entity1 - @entity0 treated by transfixation with Kirschner wires with a special focus on the remodelling process of the hips under this fixation method. METHODS: 30 @entity0 with stable @entity1 (mean initial slip angle: 29  , mean follow-up: 10 years), who were treated with bilateral transfixation by Kirschner wires, were recruited for this study. At most recent follow-up @entity0 were clinically and radiologically ( @entity2 ) examined. Medical records were reviewed for previous follow-up time points. RESULTS: Range of motion: At most recent follow-up the mean range of motion was: extension/flexion: 0/0/121, abduction/adduction: 44/0/31, external rotation/internal rotation: 39/0/24. Nearly all dimensions of motion significantly improved during the postoperative course.Head-shaft angle: We saw a significant reduction of the mean head-shaft angle from 29   preoperatively to 11   at most recent follow-up (p<0.0001).Harris Hip Score (HHS): 24 @entity0 had an excellent, 3 a good, 2 a fair and 1 a poor outcome defined by HHS.Remodelling: At most recent follow-up 25 @entity0 achieved complete remodelling. The remodelling process took place especially during the first postoperative year.Angle alpha: The mean angle alpha of the affected hips at most recent follow-up was 62  . CONCLUSIONS: Transfixation with Kirschner wires leads to very good clinical, functional and radiologic results with a low complication rate. Furthermore the femoral head-neck junction retains enough plasticity for an active remodelling process.

title: Slipped XXXX : long-term outcome and remodelling after in situ fixation.

answer: @entity1


abstract: PURPOSE: The authors describe a modified technique of primary transanal rectosigmoidectomy for @entity2 ( @entity2 ), using a Swenson like procedure to perform the anastomosis between the colon and the rectum, and the preliminary results from this in @entity0 . METHODS: Twenty @entity0 , of whom, 90% were @entity0 and 10% @entity0 , 50% white and 50% nonwhite, aged 15 days to 10 years and with @entity2 proven via biopsy, underwent a transanal pull-through procedure over a 29-month period. Postoperative follow-up ranged from 29 to 5 months. The proximal cut edge of the mucosal and submucosal cuff was tagged with multiple @entity4 4-0 sutures, which were used for traction of the intestinal layers outside. The rectal mucosa was incised circumferentially using cautery, to perform rectal dissection approximately 1.5 cm from the dentate line, except in newborn case, in which the proximal cut edge was 0.5 cm from the dentate line. The dissection extended in an upward direction around the entire rectal circumference as far as the opening of the peritoneal reflection. The full thickness of rectum and sigmoid were mobilized outside through the anus, with division and coagulation of the rectal and sigmoid vessels using cautery or ligatures with @entity3 4-0. The dissected colon then was divided above the transition zone, which was confirmed via full-thickness biopsy sections and with frozen section confirmation of ganglion cell presence. The authors performed a modified Swenson anastomosis technique, using a seromuscular polyglactin 4-0 separate-stitch suture. No drains were used. RESULTS: Normal bowel movements were displayed by all @entity0 at the follow-up. All @entity0 underwent a defecogram and anorectal computerized manometry at 3 months after surgery that showed an @entity1 and good anorectal sphincter muscle complex function. The incidence of complications in our series was 10%. CONCLUSIONS: During the follow-up period of 29 months, all @entity0 had normal bowel movements and normal anorectal manometric pressure profiles.

title: Modified transanal rectosigmoidectomy for XXXX : clinical and manometric results in the initial 20 cases.

answer: @entity2


abstract: @entity0 were sleep deprived by the platform method to look for differential effects on light and deep slow wave sleep depending on platform size. Diameters of large and small platforms were 15 cm and 5.1 cm respectively. Sleep was recorded during a baseline light period (09.00-19.00 h), continuously during 48 h of @entity2 and during the first lights on recovery period (09.00-19.00 h). In both platform conditions REM sleep was virtually abolished during the first light period (hours 0-10 of @entity2 ), while NREM sleep was reduced to approximately half of control values. During the second light period (hours 22-34 of @entity2 ) REM sleep recovered somewhat in the large platform group. Light slow wave sleep ( @entity1 -1) was comparable to baseline while deep slow wave sleep ( @entity1 -2) was still significantly reduced. In the small platform group both @entity2 was considerably reduced on day 2. Over the whole deprivation period there was an effect of platform size on @entity1 -1 (higher in the small platform group), and on @entity2 (lower in the small platform group). During the 9 h light-time recovery sleep there was an REM sleep rebound in both groups. @entity1 -1 was reduced in both groups while @entity1 -2 was not significantly increased. The ratio @entity1 -2/ @entity1 -1 was, however, significantly increased only in the small platform group recovery sleep. The results suggest that platform @entity2 deprives the animals of deep slow wave sleep in addition to REM sleep. This has implications for conclusions on REM sleep function based upon @entity2 .

title: Platform XXXX affects deep slow wave sleep in addition to REM sleep.

answer: @entity2


abstract: The left ventricular (LV) posterior wall in @entity0 with @entity4 or prior @entity2 ( @entity2 ) frequently demonstrates normal or supernormal motion to compensate for hypokinesis of the interventricular septum. This study evaluated the systolic motion velocity of the posterior wall in these conditions using a pulsed tissue Doppler imaging system. The study population consisted of 30 @entity0 with @entity3 ( @entity3 ) and @entity4 , 25 with prior @entity2 and 30 normal controls. The systolic excursion of the posterior wall was obtained by M-mode echocardiography. The endocardial motion velocities of the posterior wall were obtained by pulsed tissue Doppler imaging. The systolic excursion of the posterior wall was significantly greater in the @entity2 and @entity3 groups than in the control group, and was significantly greater in the @entity2 group than in the @entity3 group. The peak systolic velocity of the posterior wall was significantly lower in the @entity3 group than in the control and @entity2 groups, and the time from the electrocardiographic Q wave to the peak of the systolic wave of the posterior wall was significantly longer in the @entity3 group than in the other groups. There were rough negative and positive correlations between the LV end-diastolic pressure and the peak systolic velocity and time from the Q wave to the peak of the systolic wave, respectively. In conclusion, LV myocardial contractility in @entity3 @entity0 was impaired when compared to @entity2 @entity0 despite similar posterior wall motion on the M-mode echocardiogram. Pulsed tissue Doppler imaging method may provide new insights and allow further evaluation of @entity1 .

title: Difference in systolic motion velocity of the left ventricular posterior wall in XXXX with @entity4 and prior @entity2 . Evaluation by pulsed tissue Doppler imaging.

answer: @entity0


abstract: PURPOSE: The current recommended practice for pediatric @entity0 with metastatic @entity5 includes full-dose radiotherapy to each metastatic site. We wished to question this practice, which can cause side-effects and is often logistically challenging, by studying the pattern of failure in our pediatric and teenage @entity0 population. METHODS AND MATERIALS: Our institution's @entity2 registry was queried for @entity0 diagnosed with @entity5 aged 18 or less from January 1990 until January 2014. Twenty-nine @entity0 were found and, of these, six had @entity1 . Five of the six were treated with standard chemotherapy together with radiotherapy to the primary and metastatic sites with doses and fractionation according to the site. Progression-free survival was calculated from the end of radiotherapy until radiological or pathological evidence of disease progression  or @entity4 . RESULTS: Median age was 13 years (range: 12-18).  Three were @entity0 . All had alveolar histology and unfavorable primary sites. Twelve metastatic sites were treated with radiotherapy. Doses used were 41.4 - 50.4 Gy in 1.8 Gy fractions for most sites, and 15 Gy in 1.5 Gy fractions for whole lung radiotherapy. The median number of sites treated per @entity0 was two (range: 1 - 6). Median time to progression was 10.1 months (range: 1.9 - 15.7).  Local control was 100% for all metastatic sites. Median overall survival (OS) was 31.8 months (range: 20.4 - 95.4 months). Three @entity0 developed @entity3 outside the treated field. One @entity0 died from a secondary @entity6 without evidence of disease progression. One @entity0 remains progression-free at 88.6 months post-radiotherapy. CONCLUSIONS: Radiotherapy to @entity1 sites prevented in-field progression in all five @entity0 with metastatic @entity7 . However, failure at sites outside of the radiotherapy volume occurred in three of five of @entity0 and overall survival was very poor despite aggressive treatment to all sites of disease. Radiotherapy has a role in @entity1 , although future studies evaluating dose and fractionation are needed.

title: Radiotherapy is Important for Local Control at Primary and Metastatic Sites in XXXX .

answer: @entity5


abstract: We evaluated the prevalence of @entity3 in @entity0 who have taken anorectic medications. Two-dimensional echocardiograms with color flow Doppler were recorded in 200 consecutive @entity0 referred to a major metropolitan hospital for evaluation of cardiac function because of a history of anorectic medication use. Each @entity0 filled out a questionnaire at the time of the visit or through telephone contact. Each echocardiogram was reviewed by 2 observers. The degree of @entity3 was graded by a consensus of both observers. Significant @entity3 was defined as at least moderate @entity2 ( @entity2 ) or at least mild @entity1 ( @entity1 ), as recommended by the Food and Drug Administration and Centers for Disease Control and Prevention. For all @entity0 having taken anorectic drugs, there was a 5% prevalence of at least moderate @entity2 , a 12% prevalence of at least mild @entity1 , and a 16% prevalence of significant @entity2 and/or @entity1 . @entity0 with significant @entity1 and/or @entity2 were older than those without significant @entity3 (49+/-12 vs 44+/-11 years, p = 0.03). @entity0 with significant @entity2 and/or @entity1 had a longer exposure duration (8 vs 6 months, p = 0.049) to anorectic drugs. There was no difference in weight loss between those with and without significant regurgitation (p = NS). The 2 largest subgroups were @entity0 who took the @entity4 - @entity6 combination (n = 127) and those who took @entity5 alone (n = 42). The prevalence of significant @entity2 and @entity1 was 5% and 9% for the @entity4 - @entity6 group and 0% and 14% for the @entity5 group, respectively. There was also a high subthreshold level of @entity2 and @entity1 in these @entity0 .

title: Echocardiographic prevalence of mitral and/or XXXX in @entity0 exposed to either @entity4 - @entity6 combination or to @entity5 .

answer: @entity1


abstract: Recently, we have shown that @entity4 ( @entity5 ) treatments increase @entity7 mutant frequency in the liver, kidney and lung but not in other organs, and also enhance cell proliferation only in the bronchial epithelia. In the present study, organ specificity of @entity6 induced by @entity5 was compared to those of @entity7 mutation and cell proliferation in Big Blue @entity2 . Male 8-week-old Big Blue @entity2 were treated with daily i.p. injections of 1 or 10 mg/kg @entity5 for 5 days, or a single i.p. injection of 5 or 10 mg/kg @entity5 . Except for the 10 mg/kg x 5 @entity5 group, all animals survived until 78 weeks after the first treatment of @entity5 . In the present study, the induction of cell proliferation in the bronchial epithelia was confirmed in a dose-dependent manner. At the termination of 78 weeks, it was histopathologically shown that the @entity5 -treated @entity2 developed liver cell tumor in three out of seven (43%) of the 5 mg/kg group, @entity1 in three out of seven (43%) of the 1 mg/kg x 5 group, and @entity3 in one of seven (14%) of the 1 mg/kg x 5 group, although no neoplastic or preneoplastic lesions were found in the control @entity2 . Because non-transgenic C57BL/6 @entity2 are resistant to developing spontaneous liver cell and duodenal @entity0 , it was speculated that even these low doses of @entity5 could be sufficient to initiate target cells. Our results thus suggest that organ specificity of @entity6 by @entity5 is in favorable agreement with that of @entity7 mutation but not with possibly temporal cell proliferation induced by @entity5 .

title: Comparative study on organ-specificity of @entity6 , mutagenicity and cell proliferative activity induced by XXXX in Big Blue @entity2 .

answer: @entity4