abstract: UNASSIGNED: The mechanisms of @entity3 after @entity2 - @entity1 (HI) are different in the immature and the adult brain, but microglia activation has not been compared. The purpose of this study was to phenotype resident microglia and blood-derived macrophages in the hippocampus after HI in neonatal (postnatal day 9, P9) or adult (3 months of age, 3mo) @entity0 . Unilateral @entity4 after HI was induced in @entity8 (GFP/+) @entity7 (RFP/+) male @entity0 on P9 (n   =   34) or at 3mo (n   =   53) using the Vannucci model. Resident microglia ( @entity8 -GFP+) proliferated and were activated earlier after HI in the P9 (1-3 days) than that in the 3mo hippocampus, but remained longer in the adult brain (3-7 days). Blood-derived macrophages ( @entity7 -RFP+) peaked 3 days after HI in both immature (P9) and adult (3mo) hippocampi but were twice as frequent in adult brains, 41% vs. 21% of all microglia/macrophages. @entity5 expression was three times higher in the P9 hippocampi, indicating that the proinflammatory response was more pronounced in the immature brain after HI. This corresponded well with the higher numbers of galectin-3-positive resident microglia in the P9 hippocampi, but did not correlate with @entity9 /32- or @entity6 -positive resident microglia or blood-derived macrophages. In conclusion, resident microglia, rather than infiltrating blood-derived macrophages, proliferate and are activated earlier in the immature than in the adult brain, but remain increased longer in the adult brain. The inflammatory response is more pronounced in the immature brain, and this correlate well with galectin-3 expression in resident microglia. GLIA 2015;63:2220-2230.

title: Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after XXXX - @entity1 .

answer: @entity2


abstract: The effect of @entity7 on the oligosaccharide structure of follicle-stimulating hormone (FSH) isoforms was studied in adult male @entity0 treated with a potent @entity3 (GnRH) antagonist. Animals were castrated (Cx), and 24 h later were treated with physiological doses of either @entity6 (T) or @entity9 ( @entity2 ) (0.25 mg/ @entity0 in @entity8 oil, daily, s.c.) for 7 days. The antiandrogen @entity10 (F; 5 mg/day/ @entity0 , twice a day, s.c.) was administered to either @entity4 or Cx- @entity2 @entity0 to block @entity1 action. The GnRH antagonist @entity12 ( @entity11 mg/kg/day, s.c.) was injected to both Cx- and Cx- @entity2 treated rats. FSH serum levels reached normal values in Cx @entity0 treated with either T or @entity2 , whereas those treated with F retained Cx conditions. Both Cx-Ant and Cx-Ant- @entity2 treated animals presented normal serum FSH levels. Concanavalin A affinity chromatography was used to isolate pituitary FSH isoforms according to their @entity5 inner structure. An increased proportion of FSH isoforms bearing complex-type oligosaccharides was observed in Cx @entity0 treated with T or @entity2 , whereas the proportion of these isoforms was reduced in Cx and @entity4 -F or Cx- @entity2 -F @entity0 . These results demonstrate that functional @entity7 are needed to complete the oligosaccharide processing of FSH. In addition, the proportion of the different pituitary FSH isoforms after @entity2 replacement was equivalent to that found when @entity3 action was blocked, indicating that @entity7 are involved in the regulation of @entity5 incorporation to the FSH molecule by acting mainly at the pituitary level, independently of GnRH action.

title: Effect of dihydrotestosterone on pituitary follicle-stimulating hormone isoforms in adult male @entity0 treated with a XXXX antagonist.

answer: @entity3


abstract: BACKGROUND: @entity2 exposure during development has been shown to alter a variety of social behaviors in both @entity0 and rodents. Sexual behavior in rodents has been well characterized and lends itself to a detailed investigation of the manner in which @entity3 impacts this particular social behavior. METHODS: @entity1 were exposed to @entity3 during both the prenatal and early postnatal period (ET). Control groups included @entity1 exposed to the administration procedures alone (intubated-control) and nontreated controls (NC). Sexual behavior of intact na  ve female @entity1 in estrus was assessed in adulthood (approximately postnatal day 90) and activity was measured by the number of crossings between chambers in the 3-chamber test apparatus. A separate study examined the olfactory preferences for 4 odors by intact na  ve female @entity1 in all 3 groups. The 4 odors were the odors resulting from 1 hour of occupation of the test chamber by an intact male, 1 hour of occupation of the test chamber by a gonadectomized male, 0.5 ml of urine from an intact male, and 0.5 ml of urine from a gonadectomized male. RESULTS: ET female @entity1 showed a reduced return latency after ejaculation compared to both control groups. There was a trend toward a reduction in percent exits after all forms of male behavior in the ET animals compared to the control groups. No significant differences across groups were seen in the @entity4 quotient, activity, or the behavior of the nonexperimental male. ET female @entity1 showed a reduced preference for the odor from the intact male compared to both control groups and a reduced preference for the odor from the gonadectomized male compared to NC females only. CONCLUSIONS: These data suggest that @entity3 exposure during the prenatal and postnatal period in females alters sexual motivation and changes the processing of olfactory cues and possibly coital cues from male @entity1 .

title: XXXX exposure during development: analysis of effects on female sexual behavior.

answer: @entity2


abstract: This paper describes the findings of an ethnographic study that sought to explore the influence of @entity1 / @entity2 on the practice of primary care nurses in Jordan. The study was undertaken in three (3) rural and three (3) urban comprehensive primary health care centres. Data collection included @entity0 observation, key informant interviews, field notation and document analysis. These data informed the development of descriptive ethnographic accounts that allowed for the subsequent identification of common and divergent themes reflective of factors recognized as influencing the practice of nurses. The findings indicate that the ability of the nurses to raise awareness and therefore reduce the spread of @entity1 / @entity2 is unrealistic. Data shows that the population is at risk because the nurses' knowledge and skill base is inadequate and the health care facilities are crippled by limited @entity0 and physical resources. Poor management and the lack of localised leadership are also factors identified as contributing to the vulnerability of Jordanians. Enhanced commitment from the Ministry of Health and the senior nursing administration in Jordan is required if the comprehensive primary health care centres are to meet expectations and improve health outcomes of the population. Funding must be directed to improve the infrastructure of the comprehensive primary health care centres and adequate concurrent funds provided for the purchase of non-capital items. It is crucial that support be made available to up-skill the nursing staff and superior recruitment and retention initiatives implemented to address the current nursing shortages.

title: Jordan's vulnerability: a population at risk of @entity1 / XXXX .

answer: @entity2


abstract: BACKGROUND: In a new health care economy, there is an emerging need to understand and quantify predictors of @entity3 ( @entity3 ) outcomes. We investigated the association between preoperative radiographic disease (as measured quantitatively by joint space width [JSW]) and @entity0 -reported function, activity, @entity1 , and quality of life after @entity3 . METHODS: We retrospectively analyzed 146 @entity0 (146 hips) 55 years or younger with a diagnosis of @entity2 who underwent cementless @entity3 between January 2009 and December 2010. Preoperative pelvic radiographs were measured by 1 author blinded to clinical outcomes to establish JSW, defined as the shortest distance between the femoral head margin and the superolateral weight-bearing portion of the acetabulum. The JSW value was treated as a continuous variable when applied to statistical modeling. The relationship between the JSW and the improvement of clinical outcome was examined via a general linear modeling approach with adjustments for @entity0 ' age, body mass index, and sex. RESULTS: We identified an inverse relationship between preoperative JSW and improvements in functional, activity, @entity1 , and quality of life. We found that, as JSW decreased by 1 mm, the outcome measure improvements were modified Harris Hip Score of 6.3 (p<0.001); SF-12 physical: 2.1 (p=0.027); WOMAC- @entity1 : 4.8 (p=0.01); and UCLA Activity: 0.44 (p=0.02). CONCLUSIONS: Our results demonstrate that @entity0 with greater preoperative joint space have less predictable improvement in terms of function, @entity1 relief, and activity. These findings suggest that @entity3 in young @entity0 with a JSW less than 1.5 to 2 mm provides more predictable improvements in @entity1 and functional outcomes.

title: Preoperative Joint Space Width Predicts XXXX -Reported Outcomes After Total Hip Arthroplasty in Young @entity0 .

answer: @entity0


abstract: BACKGROUND: The role of endoscopy in the management of malignant-pedunculated @entity3 has been well studied, but endoscopic management of @entity3 has not. Sometimes @entity0 with @entity3 have comorbidities that make surgery exceptionally risky, and endoscopy beckons as a definitive management option. The aim of this study is to evaluate the potential role of endoscopy in the management of @entity3 . METHODS: @entity0 undergoing colonoscopic polypectomy for @entity3 by a single endoscopist from 1997 to 2010 were evaluated. Demographic data, clinicopathological variables as well as long-term outcomes were recorded. RESULTS: Sixteen @entity0 had @entity3 . Six (37.5  %) were male and 10 (62.5  %) were female. Mean age at diagnosis was 72.9      12.2  years. Six @entity3 were proximal to the @entity4 (37.5  %) and 10 (62.5  %) were distal. The mean size of the @entity3 was 30.5      15.9  mm. All @entity3 were removed endoscopically but 7 @entity0 (43.8  %) had formal colectomy following colonoscopic resection. There were no demographic differences between @entity0 with and without surgery. Piecemeal polypectomy was necessary in 8 @entity0 , 4 from the surgery group, and 4 from the endoscopy group. More @entity0 in the surgery group had poorly differentiated @entity2 (4/6 vs. 0/6) and incomplete margins (5/6 vs. 1/6) and more @entity0 in the endoscopically treated group had serious comorbidity (5/9 vs. 3/7). There was no procedure-related morbidity or mortality. After a mean follow-up of 48.4      27.2  months, one @entity0 from the polypectomy group @entity0 had a local recurrence and a liver @entity1 , after originally declining surgery. In the surgery group, one @entity0 had lung @entity1 . The two @entity0 who recurred with distant @entity1 died. CONCLUSION: Endoscopic management of sessile @entity3 appears to be feasible and safe in @entity0 with well/moderately differentiated @entity2 and negative margins. Larger studies are needed to confirm these findings.

title: Management of sessile malignant XXXX : is colonoscopic polypectomy enough?

answer: @entity3


abstract: UNASSIGNED: Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of @entity2 ( @entity2 ). @entity4 was found to play either oncogenic or @entity1 suppressive roles in @entity0 @entity1 . Recent study reported that the levels of @entity4 in late recurrent @entity2 @entity0 were evidently higher than that in early recurrent cases, suggesting that @entity4 may function as a @entity1 suppressive miRNA in @entity2 . Yet, the clinical value and biological function of @entity4 remain rarely known in @entity2 . Here, we presented that @entity4 level in @entity2 tissues was notably reduced compared to matched non-cancerous specimens. Its decreased level was evidently correlated with adverse clinical parameters and poor prognosis of @entity2 @entity0 . Accordingly, the levels of @entity4 were obviously down-regulated in @entity2 cells. Ectopic expression of @entity4 in HCCLM3 and MHCC97H cells prominently inhibits the migration and invasion of @entity1 cells and reduced lung metastases in vivo, while @entity4 knockdown increased these behaviors of HepG2 and MHCC97L cells. Mechanically, @entity4 negatively regulated @entity3 ( @entity3 ) abundance in @entity2 cells. Herein, @entity3 was found to be a downstream molecule of @entity4 in @entity2 . An inversely correlation between @entity4 and @entity3 was confirmed in @entity2 specimens. @entity3 knockdown prohibited cell migration and invasion while @entity3 overexpression showed opposite effects on @entity2 cells. Furthermore, restoration of @entity3 expression could abrogate the anti-metastatic effects of @entity4 on HCCLM3 cells with enhanced cell migration and invasion. Altogether, @entity4 potentially acts as a prognostic predictor and a drug-target for @entity2 @entity0 .

title: microRNA-489 Plays an Anti-Metastatic Role in XXXX @entity2 by Targeting @entity3 .

answer: @entity0


abstract: UNASSIGNED: Although historically restricted from combat roles, @entity0 suffer from combat-related @entity1 , especially in recent conflicts where asymmetrical warfare erases distinctions between forward and rear operating areas. U.S. servicewomen who sustained combat-related injury in @entity3 ( @entity3 ) or @entity3 ( @entity3 ) between January 2003 and May 2014 were identified from the Expeditionary Medical Encounter Database. Injuries were characterized using Abbreviated Injury Scale and International Classification of Diseases, 9th Revision codes. Of the 844 combat-related @entity1 in @entity0 , 51% (n = 433) were @entity1 and 49% (n = 411) were @entity1 . Blast events were responsible for 90% of @entity1 . The average Injury Severity Score was 3, with no statistical difference in means between @entity3 and @entity3 . Of significance were @entity2 in @entity3 compared with @entity3 (80% vs. 48%; p < 0.001). Although the majority of combat-related @entity1 suffered by @entity0 were mild, some @entity0 suffered life-threatening @entity1 , and nearly 65% of the @entity1 resulted in more than one injury. More research is needed as the roles of @entity0 in the military continue to expand. Future studies will investigate quality of life outcomes and gender differences in combat-related @entity1 .

title: Characterization and Comparison of Combat-Related Injuries in XXXX During @entity3 and @entity3 .

answer: @entity0


abstract: BACKGROUND: Emotional reactions of couples were investigated during @entity1 ( @entity1 ) at a private clinic in Sweden. The purpose was to compare such reactions between couples who obtained supernumerary embryos that could be cryopreserved and couples without such embryos. METHODS: Forty @entity0 and @entity0 undergoing @entity1 treatment monitored individually their emotional reactions daily for one complete treatment cycle from the first day of down-regulation until the outcome of treatment was known. Ratings were extracted and analyzed from two separate days; the very first day of treatment and the day of embryo transfer. RESULTS: The group of @entity0 (n=16; 40%) with supernumerary embryos suitable for cryopreservation reported a greater increase in optimism than the group (n=24; 60%) without such embryos (p=0.024). Correspondingly, @entity0 with supernumerary embryos reported less pessimism than @entity0 without such embryos (p=0.014). Among @entity0 there was no difference in optimism or pessimism between the groups. The @entity0 and @entity0 with supernumerary embryos did not differ in distress reactions compared to those @entity0 and @entity0 without such embryos. There was no correlation between optimism and distress on the day of embryo transfer in @entity0 ; r=-0.167 and @entity0 ; r=-0.135 respectively. CONCLUSION: The presence of frozen embryos increased optimistic and reduced pessimistic feelings about pregnancy among @entity0 undergoing @entity1 treatment. However, the couples' increased optimism on the day of embryo transfer did not seem to reduce their experience of distress.

title: The impact of frozen embryos on emotional reactions during XXXX .

answer: @entity1


abstract: PURPOSE: To determine whether serum levels of @entity2 ( @entity2 ) could differentiate @entity8 @entity0 , @entity5 -exposed individuals, and unexposed controls. EXPERIMENTAL DESIGN: Hyperacetylated and nonacetylated @entity2 (together referred to as total @entity2 ) were blindly measured in blood collected from @entity8 @entity0 (n= 22), individuals with verified chronic @entity5 exposure (n= 20), @entity0 with benign @entity4 (n= 13) or @entity7 not due to @entity8 (n= 25), and healthy controls (n= 20). Blood levels of previously proposed @entity8 biomarkers @entity9 , mesothelin, and @entity3 were also measured in nonhealthy individuals. RESULTS: @entity2 serum levels reliably distinguished @entity8 @entity0 , @entity5 -exposed individuals, and unexposed controls. Total @entity2 was significantly higher in @entity8 @entity0 and @entity5 -exposed individuals compared with healthy controls. Hyperacetylated @entity2 was significantly higher in @entity8 @entity0 compared with @entity5 -exposed individuals and healthy controls, and did not vary with @entity1 stage. At the cut-off value of 2.00 ng/mL, the sensitivity and specificity of serum hyperacetylated @entity2 in differentiating @entity8 @entity0 from @entity5 -exposed individuals and healthy controls was 100%, outperforming other previously proposed biomarkers. Combining @entity2 and @entity9 provided increased sensitivity and specificity in differentiating @entity8 @entity0 from @entity0 with cytologically benign or malignant non- @entity6 @entity4 . CONCLUSIONS: Our results are significant and clinically relevant as they provide the first biomarker of @entity5 exposure and indicate that hyperacetylated @entity2 is an accurate biomarker to differentiate @entity8 @entity0 from individuals occupationally exposed to @entity5 and unexposed controls. A trial to independently validate these findings will start soon.Clin Cancer Res; 1-10.   2016 AACR.

title: @entity2 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify @entity6 XXXX .

answer: @entity0


abstract: OBJECTIVE: To summarize the application of protective terminal ileostomy in laparoscopic total mesorectal excision for @entity1 @entity0 , and explore the risk factors associated with @entity3 and timing of stoma closure. METHODS: Clinical data of 77 @entity0 with middle or low @entity1 undergoing laparoscopic total mesorectal excision (TME) with preventive terminal ileostomy in our department from January 2007 to December 2013 were retrospectively analyzed. Independent risk factors associated to @entity3 of terminal ileostomy were examined by logistic regression and timing of stoma closure was investigated. RESULT: The total postoperative complication morbidity was 57.1%(44/77). Electrolyte disturbance was found in 39 cases (50.6%, 39/77), including 1 case of @entity6 . @entity4 occurred in 9 cases (11.7%, 9/77). @entity7 and @entity5 was observed in 1 case (1.3%, 1/77). The result of the single factor analysis of the water electrolyte disturbance after operation, the risk factors of P<0.2 were new adjuvant chemotherapy (P=0.094), @entity1 antigen (P=0.086) and TNM staging (P=0.026); @entity2 hernia of the single factor analysis results, the risk factors of P<0.2 included uses of antidiabetic drugs (P=0.172), ASA anesthesia (P=0.168) grading and TNM stage(P=0.161); But multivariate analysis revealed no risk factors associated with the above complications (all P>0.05). Sixty-five @entity0 underwent stoma closure during follow-up, including 2 cases (3.1%) within 90 days, 20 cases (30.8%) from 90 to 180 days, and 43 cases (66.2%) more than 180 days. CONCLUSIONS: No risk factors were found to be associated with @entity3 of protective terminal ileostomy after laparoscopic TME for @entity1 @entity0 , such as electrolytes imbalance and @entity4 . The timing of stoma closure should be longer than 180 days.

title: [Risk factor analysis on XXXX after laparoscopic total mesorectal excision with preventive terminal ileostomy and timing of stoma closure in @entity1 ].

answer: @entity3


abstract: STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To retrospectively evaluate the safety and efficacy of one-stage spinal osteotomy in the treatment of severe and progressive @entity6 ( @entity6 ) associated with @entity5 ( @entity5 ). SUMMARY OF BACKGROUND DATA: For severe and @entity7 , @entity8 are often advocated for correcting the deformity. However, the safety and efficacy of one-stage spinal osteotomy in the treatment of severe and rigid @entity6 with @entity5 have been unclear thus far. METHODS: @entity0 were treated by one-stage spinal osteotomy between September 2007 and June 2011 in our hospital. The clinical records were reviewed for demographic and radiographical data, operative time, intraoperative @entity2 , blood transfusion, perioperative complications, and functional outcomes. RESULTS: There were 18 females and 11 males with an average age of 15.5    3.6 years (range, 12-28 yr). Spinal cord was longitudinally split by a @entity9 in 11 @entity0 (type I @entity5 ) and by a fibrous band in 18 @entity0 (type II @entity5 ). @entity0 were observed for a minimum of 24 months after initial surgical treatment with an average follow-up of 43.0    17.1 months (range 24-68 mo) from September 2007 to June 2013. The mean operative time and average @entity2 of type ISSCM was significantly greater than those of type II @entity5 (P < 0.05). The major curve was corrected from an average of 97.2     17.8   to 35.7     15.9  , a mean correction rate of 64.3%    11.0%. The average loss of correction at final follow-up was 2.9% for major curves. The overall complication rate was 24.1%, including transient @entity1 in 3 @entity0 , cerebrospinal fluid leakage in 2 @entity0 , @entity3 in 1 @entity0 and @entity4 in 1 @entity0 . CONCLUSION: Relative to multistage corrective surgery, one-stage spinal osteotomy is effective for the correction of severe @entity6 and @entity5 without increasing the rate of surgical complications. However, surgical treatment of type I @entity5 does require more operating time and @entity2 . LEVEL OF EVIDENCE: 4.

title: Safety and Efficacy of One-stage Spinal Osteotomy for Severe and Rigid @entity6 Associated with Split XXXX .

answer: @entity5


abstract: BACKGROUND: The ability to wait and to weigh evidence is critical to behavioral regulation. These behaviors are known as waiting and reflection @entity0 . In Study 1, we examined the effects of @entity4 , a @entity2 and @entity3 reuptake inhibitor, on waiting and reflection @entity0 in healthy young individuals. In study 2, we assessed the role of learning from feedback in @entity1 . METHODS: We used the recently developed 4-Choice Serial Reaction Time task and the Beads task. Twenty-eight healthy volunteers were tested twice in a randomized, double-blind, placebo-controlled cross-over trial with 20mg @entity4 . In the second study, we analyzed premature responses as a function of prior feedback in @entity1 . RESULTS: Study 1: @entity4 was associated with greater waiting @entity0 to a cue predicting reward along with faster responding to target onset without a generalized effect on reaction time or attention. @entity4 influenced reflection @entity0 based on baseline @entity0 . Study 2: More premature responses occurred after premature responses in stimulant-dependent subjects. CONCLUSIONS: We show that @entity4 has dissociable effects on waiting and reflection @entity0 . Chronic stimulant exposure impairs learning from prior premature responses, suggesting a failure to learn that premature responding is suboptimal. These findings provide a greater mechanistic understanding of waiting @entity0 .

title: Waiting Impulsivity: The Influence of Acute XXXX and Feedback.

answer: @entity4


abstract: BACKGROUND: @entity7 is a major modulation network among the nervous, endocrine and immune system and weights greatly in maintaining homeostasis of organisms during stress and @entity2 . Some microRNAs are found interacting with NEI system (designated NeurimmiRs), addressing @entity3 modulations on immune system. The oyster @entity8 , as an intertidal bivalve, has evolved a primary NEI system. However, the knowledge about NeurimmiRs in oysters remains largely unknown. RESULTS: Six small RNA libraries from haemocytes of oysters stimulated with @entity4 ( @entity6 ) and @entity5 (NE) were sequenced to identify neurotransmitter-responsive miRNAs and survey their immunomodulation roles. A total of 331 miRNAs (132 identified in the present study plus 199 identified previously) were subjected to expression analysis, and twenty-one and sixteen of them were found @entity6 - or NE-responsive, respectively (FDR   <   0.05). Meanwhile, 21 miRNAs exhibited different expression pattern after @entity6 or NE stimulation. Consequently, 355 genes were predicted as putative targets of these neurotransmitter-responsive miRNAs in oyster. Through gene onthology analysis, multiple genes involved in @entity1 , immune system process and response to stimulus were annotated to be modulated by NeurimmiRs. Besides, a significant decrease in haemocyte phagocytosis and late-apoptosis or @entity0 rate was observed after @entity6 and NE stimulation (p   <   0.05) while early-apoptosis rate remained unchanged. CONCLUSIONS: A comprehensive immune-related network involving PRRs, intracellular receptors, signaling transducers and immune effectors was proposed to be modulated by @entity6 - and NE-responsive NeurimmiRs, which would be indispensable for oyster haemocytes  to respond against stress and @entity2 . Characterization of the NeurimmiRs would be an essential step to understand the NEI system of invertebrate and the adaptation mechanism of oyster.

title: The comprehensive immunomodulation of NeurimmiRs in haemocytes of oyster XXXX after @entity4 and @entity5 stimulation.

answer: @entity8


abstract: BACKGROUND: @entity2 ( @entity4 )-induced @entity1 is common after liver transplantation. We evaluated the efficacy of tapering @entity4 to a very low dose and introducing @entity3 ( @entity7 ) in long-term liver-transplant recipients with @entity1 . In addition, we assessed the impact of this strategy on calcineurin inhibition and on transforming growth factor (TGF)-beta levels. METHODS: We prospectively enrolled 19 adult, long-term (>1 year) liver-transplant recipients with a decreased @entity5 clearance greater than 25% compared with the first month posttransplant. @entity7 was introduced, and @entity4 was tapered to 25 mg twice daily. Calcineurin inhibition and @entity8 were measured at baseline and 3 months thereafter. RESULTS: The @entity4 dose was tapered over 13+/-3 weeks. At 1-year follow-up, serum @entity5 decreased from 141+/-24 to 105+/-22 micromol/L (P=0.002), @entity5 clearance increased from 53+/-9 to 71+/-19 ml/min (P=0.02), and glomerular filtration rate increased from 40+/-13 to 64+/-18 mL/min (P=0.002). The incidence of acute rejection was 29%. Antihypertensive medications were discontinued in 71% of the @entity0 . Although @entity4 levels decreased significantly, serum @entity8 did not differ from normal controls, and calcineurin inhibition remained stable. The incidence of gastrointestinal side-effects and @entity6 was 18% and 24%, respectively. CONCLUSION: In long-term liver-transplant recipients with @entity1 , the introduction of @entity7 followed by tapering of @entity4 to a very low dose resulted in a significant improvement in renal function. However, this strategy maybe associated with a risk of acute rejection. The clinical pertinence of measuring serum @entity8 levels and calcineurin inhibition remains to be determined.

title: Efficacy of @entity3 combined with very low-dose @entity2 microemulsion in long-term liver-transplant @entity0 with XXXX .

answer: @entity1


abstract: UNASSIGNED: Positron emission tomography-computed tomography (PET/CT) is widely used for initial staging and monitoring treatment responses in Hodgkin and diffuse large @entity4 . However, its prognostic value in extranodal natural killer (NK)/ @entity2 (ENKL) remains unclear. Here, we conducted a retrospective study to determine the impact of PET/CT in ENKL. Fifty-two @entity0 newly diagnosed with ENKL were enrolled. Baseline maximum standardized uptake values (SUVmax), whole-body metabolic @entity1 volume (WBMTV) and whole-body total lesion glycolysis (WBTLG) were recorded. Additionally, interim PET/CT (I-PET) and end-of-treatment PET/CT (E-PET) results were scored using a 5-point scale. @entity0 were divided into groups using baseline parameter cut-off values; significant differences were found in @entity3 ( @entity3 ) and progression-free survival (PFS) between the high and low WBMTV and WBTLG groups and in @entity3 between the two SUVmax groups. Positive I-PET and E-PET results predicted @entity3 . A multivariate analysis showed that baseline WBTLG, I-PET and E-PET results were associated with PFS and @entity3 , and baseline SUVmax was an independent predictor of @entity3 . Thus, baseline WBTLG, I-PET and E-PET results are good predictors of PFS and @entity3 in ENKL @entity0 who received @entity5 /pegaspargase in their first-line treatment, and baseline SUVmax is a valuable tool for assessing @entity3 .

title: Utility of baseline, interim and end-of-treatment (18)F-FDG PET/CT in extranodal natural killer/ @entity2 XXXX treated with @entity5 /pegaspargase.

answer: @entity0


abstract: PURPOSE OF INVESTIGATION: @entity3 ( @entity3 ) is a hallmark of defective mismatch repair and is present in approximately 20% of @entity2 . It is not known if the presence of @entity3 predicts survival in @entity0 with @entity2 . MATERIALS AND METHODS: Cases of @entity2 were ascertained from a population-based study in Ontario and @entity1 samples were tested for @entity3 , using five @entity3 markers. @entity0 were divided into @entity3 -high and @entity3 -low/normal, according to National @entity1 Institute criteria. The authors compared the prevalence of specific prognostic factors in the two subgroups, including age, grade, stage, and histology. They estimated the hazard ratio for @entity4 from @entity2 associated with @entity3 -high and with other prognostic factors using a multi-variate analysis. RESULTS: A total of 418 @entity2 @entity0 were included. One hundred and twenty-seven (19.7%) @entity1 were @entity3 - high. Subgroup analyses did not reveal any statistically significant differences for pathologic features associated with @entity3 status. No survival difference was seen according to @entity3 status. CONCLUSIONS: The presence of @entity3 in @entity2 is not associated with survival.

title: Survival in @entity0 with XXXX with and without microsatellite instability.

answer: @entity2


abstract: UNASSIGNED: Ruminant animals (domesticated or wild) emit @entity2 ( @entity3 ) through enteric fermentation in their digestive tract and from decomposition of manure during storage. These processes are the major sources of greenhouse gas (GHG) emissions from animal production systems. Techniques for measuring enteric @entity3 vary from direct measurements (respiration chambers, which are highly accurate, but with limited applicability) to various indirect methods (sniffers, laser technology, which are practical, but with variable accuracy). The @entity5 (SF6)  tracer gas method is commonly used to measure enteric @entity3 production by animal scientists and more recently, application of an Automated Head-Chamber System (AHCS) (GreenFeed, C-Lock, Inc., Rapid City, SD), which is the focus of this experiment, has been growing. AHCS is an automated system to monitor @entity3 and @entity1 ( @entity4 ) mass fluxes from the breath of ruminant animals. In a typical AHCS operation, small quantities of baiting feed are dispensed to individual animals to lure them to AHCS multiple times daily. As the animal visits AHCS, a fan system pulls air past the animal's muzzle into an intake manifold, and through an air collection pipe where continuous airflow rates are measured. A sub-sample of air is pumped out of the pipe into non-dispersive infra-red sensors for continuous measurement of @entity3 and @entity4 concentrations. Field comparisons of AHCS to respiration chambers or SF6 have demonstrated that AHCS produces repeatable and accurate @entity3 emission results, provided that animal visits to AHCS are sufficient so emission estimates are representative of the diurnal rhythm of rumen gas production. Here, we demonstrate the use of AHCS to measure @entity4 and @entity3 fluxes from dairy @entity0 given a control diet or a diet supplemented with technical-grade cashew nut shell liquid.

title: The Use of an Automated System (GreenFeed) to Monitor Enteric @entity2 and XXXX Emissions from Ruminant Animals.

answer: @entity1


abstract: OBJECTIVE: To obtain the long-term follow-up information on @entity0 born with severe @entity7 associated with @entity6 who underwent a staged surgical correction of their @entity5 and were raised as males. @entity0 AND METHODS: The study comprised @entity0 who had undergone a surgical correction of @entity5 before 1978 and were traced successfully. Postal questionnaires which were completed and returned by 19 @entity0 and 28 general practitioners (GPs) were evaluated; in addition, nine cases were clinically reviewed. RESULTS: Of the 19 @entity0 who completed and returned the questionnaire, four were married or living with a partner and 12 had had intercourse, with debut at a median age of 17 years. Satisfactory erection and orgasm were reported by 15 @entity0 but only seven had satisfactory ejaculation. Nine @entity0 had continued difficulties with micturition and urological function. Four @entity0 considered that their psychological well-being and quality of life had been markedly impaired by their condition and two other @entity0 had evidence of mild @entity4 . Nine @entity0 did not complete the questionnaires but allowed their GPs to provide information about them; only one was reported to have marked @entity2 and @entity2 . Two of the @entity0 who did not participate in the study are known to have significant @entity3 problems. CONCLUSIONS: @entity1 repair in @entity0 with severe @entity7 is associated with continued difficulty with both ejaculation and micturition, but is not usually associated with major @entity3 . The findings indicate the importance of follow-up in adolescence and adult life with adequate counselling when necessary.

title: Severe XXXX with @entity6 : adult outcome after @entity1 repair.

answer: @entity5


abstract: UNASSIGNED: @entity2 ( @entity2 ) is a rare @entity4 featuring pleiotropic neurological, @entity1 and visceral manifestations. Since many of the adult manifestations can be non-specific or missed, @entity2 often goes undetected in adult-onset @entity0 . Here we hypothesized that targeted high-throughput sequencing allows identifying @entity2 @entity0 among subjects with unexplained early-onset @entity3 (EOA) and, moreover, that this population is enriched for @entity5 mutations. From 204 consecutive EOA @entity0 , all 108 subjects with an established diagnosis were removed (including 4 @entity5 @entity0 ), yielding a target cohort of 96 subjects with unexplained EOA, but without primary suspicion of @entity2 . This cohort was investigated for @entity5 / @entity6 mutations using a high-coverage HaloPlex gene panel including 122 @entity3 genes. Among 96 samples, we identified 4 known @entity5 mutations, 3 novel @entity5 missense variants of uncertain significance (VUS) and 1 novel @entity6 missense VUS. The total mutant allele frequency (8/192  =  4.17  %) was significantly enriched compared with control population data (1.57  %; p  =  0.011). Two @entity5 -positive @entity0 were identified (both with non-specific incipient clinical features), giving a @entity5 @entity0 frequency of 2/96  =  2.1  % in unexplained EOA and of 6/204  =  2.9  % in the total EOA series. @entity5 mutations are substantially enriched in unexplained EOA, demonstrating EOA as a risk-group for @entity2 disease. Targeted high-throughput sequencing allows to identify also those @entity2 @entity0 with non-specific conditions where the diagnosis has initially been missed. This method does not require having considered @entity2 during differential diagnosis, but allows identification of @entity2 as part of the default analysis.

title: XXXX is enriched in unexplained early onset @entity3 : a targeted high-throughput screening.

answer: @entity5


abstract: OBJECT: In this article the authors present a retrospective analysis of 654 surgical outcomes in @entity0 with @entity5 entrapments, @entity2 , and @entity1 during a 30-year period. METHODS: Data were gathered between 1968 and 1998 at Louisiana State University Health Sciences Center. Mechanisms of @entity2 or lesions included 460 entrapments at the elbow level (70%), 76 lacerations (12%), 52 stretches/contusions (8%), 34 @entity3 / @entity4 (5%), 12 gunshot wounds (2%), two injection-induced @entity2 (0.3%), and 13 nerve @entity1 (2%). In cases of entrapment, direct operative recordings uniformly demonstrated a slowing of conduction at the elbow, even in cases in which preoperative noninvasive studies had been nondiagnostic. Intraoperative electrical "inching" studies also demonstrated significant conduction abnormalities that lie just proximal to and through the olecranon notch rather than distal, beneath the flexor carpi ulnaris muscle. There were only eight exceptions to this. Lesions not in continuity due to the injury required primary or secondary end-to-end sutures or graft repair. Aided by intraoperative nerve action potential recording, lesions in continuity received either external or internal neurolysis and split repair or resection followed by end-to-end suture or graft repair. Functional recoveries of Grade 3 or better were seen in 81 (92%) of 88 @entity0 who underwent neurolysis, 42 (72%) of 58 @entity0 who received suture repair, and 24 (67%) of 36 @entity0 who received graft repair. Nevertheless, fewer Grade 4 or 5 recoveries were reached than those seen in @entity0 with radial or median nerve @entity2 . @entity6 were resected with preservation of preoperative function in five of seven @entity0 . CONCLUSIONS: Although difficult to obtain, useful functional recovery can be achieved with proper surgical management of @entity5 entrapments and @entity2 .

title: Surgical outcomes of 654 XXXX lesions.

answer: @entity5


abstract: UNASSIGNED: Syndecans are heparan sulfate proteoglycans characterized as transmembrane receptors that act cooperatively with the cell surface and extracellular matrix proteins. @entity4 knockdown was performed in order to address its role in endothelial cells (EC) behavior. Normal EC and shRNA- @entity4 -EC cells were studied comparatively using complementary confocal, super-resolution and non-linear microscopic techniques. Confocal and super-resolution microscopy revealed that @entity4 knockdown alters the level and arrangement of essential proteins for focal adhesion, evidenced by the decoupling of @entity2 from F-actin filaments. Furthermore, @entity4 knockdown alters the actin network leading to filopodial protrusions connected by @entity0 -rich junction. shRNA- @entity4 -EC showed reduced adhesion and increased migration. Also, @entity4 silencing alters cell cycle as well as cell proliferation. Moreover, the ability of EC to form tube-like structures in matrigel is reduced when @entity4 is silenced. Together, the results suggest a mechanism in which @entity3 acts as a central mediator that bridges @entity1 , integrin and intracellular components (actin and @entity2 ) and once silenced, the cytoskeleton protein network is disrupted. Ultimately, the results highlight @entity4 relevance for balanced cell behavior.

title: Coupling of XXXX to F-actin demands @entity3 proteoglycan.

answer: @entity2


abstract: BACKGROUND: Matrix metalloproteinases (MMPs) and Tissue Inhibitor of Matrix Metalloproteinases (TIMPs) may be associated with atherogenesis and @entity2 . We evaluated the relationship between @entity11 , @entity9 , @entity10 and @entity5 levels and risk factors, presentation, extent and severity of @entity3 ( @entity3 ). METHODS: Consecutive @entity0 who underwent coronary angiography were randomly included. The serum concentrations of @entity11 , @entity9 , @entity10 and @entity5 were analyzed with ELISA method in 134 @entity0 . @entity0 were divided into 5 groups; @entity12 ( @entity12 ; n= 34), unstable @entity7 (USAP; n=29), @entity4 ( @entity4 ; n=16), @entity4 ( @entity4 ; n=25) and controls (n=30). Coronary angiographic Gensini score was calculated. RESULTS: @entity11 levels were higher in @entity4 and @entity4 groups compared with USAP, @entity12 and control groups ( @entity4 vs USAP p=0.005; @entity4 vs @entity12 p=0.001; @entity4 vs control p<0.001; @entity4 vs USAP p=0.02; @entity4 vs @entity12 p=0.027; @entity4 vs control p<0.001). In @entity4 group, @entity9 levels were higher than USAP and control groups (p=0.002; p<0,001). @entity10 levels were not significantly different within all 5 groups. @entity11 levels were found to be elevated in @entity1 @entity0 (p=0.020); whereas @entity9 levels were higher in smokers (p=0.043). Higher @entity11 , @entity9 and @entity5 levels were correlated with severe @entity13 ( @entity13 ) @entity6 and higher angiographic Gensini Score (for severe @entity13 @entity6 ; r = 0.671, 0.363, 0.509 p<0.001; for Gensini score; r = 0.717, 0.371, 0.578 p<0.001). CONCLUSIONS: Serum levels of @entity11 , @entity9 , and @entity5 are elevated in @entity0 with @entity3 ; more so in @entity8 . @entity11 , @entity9 and @entity5 are associated with more extensive and severe @entity3 (as represented by Gensini score).

title: Relationship Between @entity11 , @entity9 , @entity10 , XXXX and Risk Factors, Clinical Presentation, Extent and Severity of @entity3 .

answer: @entity5


abstract: Angiogenesis is required for @entity1 growth and @entity0 , and inhibition of angiogenesis is a promising approach for anticancer therapy. @entity6 (a.k.a @entity6 ) is an endothelium-specific receptor @entity5 kinase known to play a role in @entity1 angiogenesis. To explore the therapeutic potential of blocking the @entity6 pathway, an adenoviral vector was constructed to deliver a recombinant, soluble @entity6 receptor (AdExTek) capable of blocking @entity6 activation. Two days after i.v. injection of AdExTek, the plasma concentration of ExTek exceeded 1 mg/ml and was maintained for about 8 days. Administration of AdExTek to @entity2 with two different well established @entity1 , a @entity2 @entity3 (4T1) or a @entity2 @entity4 (B16F10.9), significantly inhibited the growth rate of both @entity1 (64% and 47%, respectively). To study the effect of ExTek on @entity1 @entity0 , both @entity1 cell lines were coinjected i.v. with either AdExTek or a control virus. @entity2 coinjected with control virus developed numerous large, well vascularized lung metastases. In contrast, @entity2 coinjected with AdExTek virus developed few, if any, grossly apparent metastases, and histologic examination revealed only small avascular clusters of @entity1 cells. Administration of AdExTek also inhibited @entity1 @entity0 when delivered at the time of surgical excision of @entity1 in a clinically relevant model of @entity1 @entity0 . This study demonstrates the potential utility of gene therapy for systemic delivery of an antiangiogenic agent targeting an endothelium-specific receptor, @entity6 .

title: Antiangiogenic gene therapy targeting the endothelium-specific receptor XXXX kinase @entity6 .

answer: @entity5


abstract: Compared with other parts of the hand, the area beneath fingernails harbors the most microorganisms and is most difficult to clean. Artificial fingernails, which are usually long and polished, reportedly harbor higher microbial populations than natural nails. Hence, the efficacy of different hand washing methods for removing microbes from natural and artificial fingernails was evaluated. Strains of nonpathogenic @entity1 JM109 and @entity2 F9 were used as bacterial and viral indicators, respectively. Volunteers with artificial or natural nails were artificially contaminated with ground beef containing @entity1 JM109 or artificial feces containing @entity2 . Volunteers washed their hands with tap water, regular liquid soap, antibacterial liquid soap, @entity0 -based hand sanitizer gel, regular liquid soap followed by @entity0 gel, or regular liquid soap plus a nailbrush. The greatest reduction of inoculated microbial populations was obtained by washing with liquid soap plus a nailbrush, and the least reduction was obtained by rubbing hands with @entity0 gel. Lower but not significantly different (P > 0.05) reductions of @entity1 and @entity2 counts were obtained from beneath artificial than from natural fingernails. However, significantly (P < or = 0.05) higher @entity1 and @entity2 counts were recovered from hands with artificial nails than from natural nails before and after hand washing. In addition, microbial cell numbers were correlated with fingernail length, with greater numbers beneath fingernails with longer nails. These results indicate that best practices for fingernail sanitation of food handlers are to maintain short fingernails and scrub fingernails with soap and a nailbrush when washing hands.

title: A comparison of hand washing techniques to remove XXXX and caliciviruses under natural or artificial fingernails.

answer: @entity1


abstract: UNASSIGNED: Allogeneic stem cell transplantation (allo-SCT) outcomes in @entity0 with @entity1 ( @entity1 ) remain poorly defined. We performed a meta-analysis of allo-SCT studies in @entity1 @entity0 . The primary endpoints were 6-month, 1-year, 2-year and 3-year relapse-free survival (RFS) and @entity2 ( @entity2 ). A total of 42 reports (1850 @entity0 ) was included. The pooled estimates (95% confidence interval) for 6-month, 1-year, 2-year and 3-year RFS were 77 (59-91)%, 50 (42-57)%, 37 (31-43)% and 31 (25-37)%, respectively. The corresponding numbers for @entity2 were 83 (75-91)%, 68 (62-74)%, 58 (52-64)% and 50 (41-58)%, respectively. There was statistical heterogeneity among studies in all outcomes. In meta-regression, accrual initiation year in 2000 or later was associated with higher 6-month (P=0.012) and 1-year @entity2 (P=0.046), and pre-SCT remission with higher 2-year @entity2 (P=0.047) and 1-year RFS (P=0.016). In conclusion, outcomes of allo-SCT in @entity1 have improved over time, with 5-10% lower non-relapse mortality and relapse rates, and 15-20% higher RFS and @entity2 in studies that initiated accrual in 2000 or later compared with earlier studies. However, there is no apparent survival plateau, demonstrating the need to improve on current allo-SCT strategies in relapsed/refractory @entity1 .Bone Marrow Transplantation advance online publication, 4 January 2016; doi:10.1038/bmt.2015.332.

title: Allogeneic hematopoietic stem cell transplantation in XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: @entity8 refers to a group of uncommon and frequently fatal mycoses caused by fungi of the class Zygomycetes, the organisms of which are usually found in decaying organic matter. Disease can be transmitted by the inhalation of spores or by direct inoculation on disrupted skin or mucosa. For @entity3 such as @entity8 , two or more cases occurring in a short time should be investigated as a probable @entity5 . Twelve hospital outbreaks and two pseudoepidemics caused by Zygomycetes have been cited in the English literature. The first @entity5 was recorded in 1977 and the last in 2008. Outbreaks have been reported in the USA, the UK and elsewhere in Europe. Cases have included cutaneous, disseminated, @entity2 . Species identified have included @entity7 , Rhizopus rhizopodiformis, Rhizopus microsporus, Rhizopus spp., Absidia corymbifera and Rhizomucor pusillius. Sources of infection have included Elastoplast adhesive bandage rolls, ventilation systems, @entity6 , karaya (plant-derived adhesive) ostomy bags, and water damage to a linen store and @entity0 shower room. @entity0 have included cardiosurgery @entity0 , renal transplant recipients, orthopaedic @entity0 , adult @entity4 @entity0 , intensive care unit neonates, immunocompromised haematology @entity0 , and burn unit @entity0 . Although @entity8 outbreaks in the hospital environment are infrequent, a high index of suspicion should exist if @entity1 appear in proximity to a postoperative wound. Direct tissue examination and tissue culture and histopathology must be routinely performed.

title: Outbreaks of XXXX in hospitals.

answer: @entity8


abstract: OBJECTIVE: Although there are still some controversies, large previous studies have confirmed that intravenous (i.v.) @entity6 ( @entity7 ) can effectively reduce @entity2 and transfusions in @entity5 ( @entity5 ) without increasing the risk of @entity9 . However, few studies have investigated the combination of i.v. and topical application of @entity7 in primary @entity5 . The purpose of our current study is to examine whether i.v. combined with topical administration of @entity7 @entity1 and transfusion rates after @entity5 . METHODS: From December 2013 to May 2014, all adult @entity0 undergoing primary @entity5 at our arthroplasty center were considered for inclusion in the present study. Included @entity0 were randomly assigned to two groups by computer-generated list number: a @entity7 group and a placebo group. @entity0 in the @entity7 group received i.v. (15   mg/kg) combined with topical administration (1.0   g) of @entity7 during the @entity5 procedure, and @entity0 in the other group received the same dosage of normal saline both i.v. and topically. Our primary outcome measures were @entity2 (calculated using Gross's equation), hemoglobin, hematocrit and platelet concentration changes on the third postoperative day, the amount of drainage, the amount of intraoperative @entity2 , the frequency of transfusion, and the number of blood units transfused. Secondary outcome measures were the length of postoperative stay, range of hip motion (measured by goniometer), @entity5 ( @entity5 ), and any perioperative @entity4 or events such as @entity3 , @entity11 or PE. Range of motion and @entity5 were measured at 3   week follow-up and compared with preoperative values. RESULTS: This trial included 100 @entity0 (50 in each group). @entity0 in the @entity7 group had significantly higher postoperative hemoglobin (103 vs 87.7   g/dL, P < 0.01), lower hemoglobin changes (32.2 vs 44.9   g/dL, P < 0.01), higher postoperative hematocrit (0.32 vs 0.27   L/L, P < 0.01), lower hematocrit changes (0.1 vs 0.14   L/L, P < 0.01), @entity2 (822 vs 1100   mL, P = 0.004), lower drainage (117.8 vs 242.4   mL, P < 0.01), lower intraoperative @entity2 (193.8 vs 288.2   mL, P < 0.01), and lower transfusion rate (2% vs 34%, P < 0.01) compared with those in the placebo group. No statistical difference was found in postoperative platelets between the two groups. There were no differences in perioperative @entity4 or @entity10 ( @entity10 ) events. CONCLUSIONS: The combined administration of i.v. and topical @entity7 resulted in a clinically relevant reduction in @entity2 , compared with placebo group. No @entity8 @entity4 were observed. This randomized controlled trial supports the combined i.v. and topical administration of @entity7 in primary @entity5 .

title: Intravenous Combined with Topical Administration of XXXX in Primary Total Hip Arthroplasty: A Randomized Controlled Trial.

answer: @entity6


abstract: BACKGROUND: Maternal @entity1 and @entity4 increase risk of @entity1 and @entity0 in offspring later in life. OBJECTIVE: We examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort. DESIGN: Pregnant mothers undertook a 75-g 2-h oral- @entity2 -tolerance test at 26-28 wk of gestation. In 937 singleton offspring,  <=9 serial measurements of weight and length were obtained from birth until 36 mo of age. RESULTS: Gestational fasting plasma @entity2 (FPG) was positively associated with birth weight (B: 0.17; 95% CI: 0.10, 0.24; P < 0.001) and birth BMI (B: 0.15; 95% CI: 0.06, 0.40; P = 0.001) but not at >= 3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy @entity1 status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% CI: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in @entity1 mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: -0.01; 95% CI: -0.02, -0.003) and BMI (B: -0.008; 95% CI: -0.01, -0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life. CONCLUSIONS: Prepregnancy @entity3 was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and @entity1 mothers separately. This study was registered at clinicaltrials.gov as NCT01174875.

title: Associations of gestational glycemia and prepregnancy @entity3 with offspring growth and XXXX in an Asian population.

answer: @entity3


abstract: BACKGROUND/AIM: @entity2 is a potential factor contributing to @entity8 . @entity5 depletes intestinal integrity and causes gut @entity9 . @entity6 , a fermentation byproduct of gut microbiota, is altered negatively following chronic @entity5 exposure. This study aimed to determine whether prophylactic @entity10 could protect the intestinal barrier and liver in @entity0 during combined chronic-binge @entity5 exposure. METHODS: C57BL/6   J @entity0 exposed to 5% v/v @entity5 -containing diet for 10   days received a single @entity5 gavage (5   g/kg) 9   hrs prior to euthanasia. Control @entity0 were isocalorically pair-fed maltose dextrin for @entity5 . Diets were supplemented (5   mM) with @entity10 or @entity4 . Intestine and @entity2 activity was assessed histologically. Protein and mRNA expression of tight junction proteins (TJ), TLRs and @entity3 were assessed. Caco-2 monolayers with/without @entity5 exposure and/or @entity7 were used to test @entity6 's direct effects on intestinal integrity. RESULTS: Chronic-binge @entity5 feeding impaired intestinal TJ protein co-localization staining; however, @entity10 co-treatment mitigated these effects. @entity5 depleted TJ and transepithelial electrical resistance in Caco-2 monolayers, but @entity6 co-treatment reduced these effects. Hepatic TLR mRNA expression and @entity3 protein expression was induced by @entity5 ; however, the response was significantly dampened in @entity0 co-treated with @entity10 . @entity10 altered localization of both neutrophils and single hepatocyte death: leukocytes and apoptotic hepatocytes localized predominantly around the portal tract in @entity5 -only treated @entity0 , whereas localization predominated around the central vein in @entity5 - @entity10 @entity0 . CONCLUSIONS: Prophylactic @entity10 supplementation mitigated effects of combined chronic-binge @entity5 exposure on disruption of intestinal TJ localization and intestinal permeability and @entity1 .

title: Prophylactic XXXX treatment mitigates chronic-binge alcohol-induced intestinal barrier and @entity1 .

answer: @entity10


abstract: The DSM-IV section of the DSM-IV and ICD-10 Personality Questionnaire (DIP-Q) was used to screen for @entity4 in 448 subjects from three clinical samples (general and forensic @entity2 @entity0 and candidates for psychotherapy) and a sample of 139 healthy volunteers. Differences between the samples with regard to patterns of personality pathology in relation to concurrent @entity1 and sociodemographic variables were analysed. The prevalence of @entity4 according to DIP-Q was 14% among the healthy volunteers, compared to 59% in the general @entity2 sample, 68% in the forensic @entity2 sample and up to 90% among psychotherapy candidates. Moreover, from a dimensional perspective (i.e. the number of fulfilled @entity5 ), all clinical groups differed significantly from the control group in all specified personality dimensions and clusters. Dimensional DIP-Q cluster scores also discriminated significantly between the three clinical samples. Unexpectedly, the odds ratio for an @entity1 was nearly five times higher among psychotherapy applicants than among general @entity2 @entity0 , independent of concomitant @entity1 , gender or age. The strongest association between DIP-Q score and @entity1 was found for @entity3 , which more than doubled the odds ratio for a @entity4 diagnosis. This association could result from high true comorbidity, but could also be due to the fact that a concomitant @entity3 state can increase self-reported personality difficulties. The high prevalence among psychotherapy candidates may to some extent reflect help-seeking exaggeration of problems. These are aspects to consider when using the DIP-Q, which overall appears to discriminate well between different samples.

title: Validation of the self-report questionnaire DIP-Q in diagnosing DSM-IV XXXX : a comparison of three @entity2 samples.

answer: @entity4


abstract: @entity1 is a worldwide uncontrolled @entity7 due to the lack of effective drug and vaccine. To speed up effective drug development, we need powerful methods to rapidly assess drug effectiveness against the intracellular form of @entity6 in high throughput assays. Reporter gene technology has proven to be an excellent tool for drug screening in vitro. The effects of reporter proteins on parasite infectivity should be identified both in vitro and in vivo. In this research, we initially compared the infectivity rate of recombinant @entity6 expressing stably enhanced green fluorescent protein (EGFP) alone or EGFP-luciferase (EGFP-LUC) with the wild-type strain. Next, we evaluated the sensitivity of these parasites to @entity5 ( @entity2 ) as a standard drug in 2 parasitic phases, promastigote and amastigote. This comparison was made by @entity0 and @entity3 (NO) assay and by quantifying the specific signals derived from reporter genes like EGFP intensity and luciferase activity. To study the amastigote form, both B10R and @entity4 macrophage cell lines were infected in the stationary phase and were exposed to @entity2 at different time points. Our results clearly revealed that the 3 parasite lines had similar in vitro infectivity rates with comparable parasite-induced levels of NO following interferon-y/lipopolysaccharide induction. Based on our results we proposed the more reporter gene, the faster and more sensitive evaluation of the drug efficiency.

title: In Vitro Infectivity Assessment by Drug Susceptibility Comparison of Recombinant XXXX Expressing Enhanced Green Fluorescent Protein or EGFP-Luciferase Fused Genes with Wild-Type Parasite.

answer: @entity6


abstract: UNASSIGNED: Increased atmospheric [ @entity2 ] is likely to affect photosynthesis, plant growth, and yield potential of plants. Mustard ( @entity3 L.) is an important oil seed crop that is widely grown in India. Therefore, the impact of elevated [ @entity2 ] (585   mol  mol(-1)) on pigment and protein content, chlorophyll a fluorescence, photosynthetic electron transport reactions, @entity2 assimilation, biomass production, and seed yield potential was measured in @entity3 cv Pusa Bold, grown inside free air @entity1 enrichment (FACE) rings installed on the campus of Jawaharlal Nehru University, New Delhi, India. Plants were grown for three consecutive winter seasons (2010-2013), in ambient (385   mol  mol(-1)) or elevated [ @entity2 ], in field conditions. Elevated [ @entity2 ] had no significant effect on the minimal @entity0 fluorescence (F 0), while the quantum efficiency of Photosystem II, measured as variable fluorescence (F v   =   F m-F 0) to maximum fluoresence (F m), increased by 3  %. Electron transport rate, photosystem I, photosystem II, and whole chain electron transport rates increased by 8  % in elevated [ @entity2 ]. However, the net photosynthesis rate increased by    50  % in three growing seasons under elevated [ @entity2 ] condition. The stomatal conductance and transpiration rate decreased resulting in higher photosynthetic water use efficiency. The photosynthesizing surface, i.e., leaf area index substantially increased leading to higher biomass and seed yield under elevated [ @entity2 ] condition. Acclimatory downregulation of photosynthesis and plant productivity was not observed in three consecutive growing years suggesting that in the absence of nutrient limitation, @entity3 is highly responsive to elevated @entity2 whose yield potential shall increase in changing climatic conditions.

title: Photosynthesis and growth responses of mustard ( @entity3 L. cv Pusa Bold) plants to free air XXXX enrichment (FACE).

answer: @entity1


abstract: The @entity2 of transvenous cardioversion shocks in awake @entity0 is an important clinical problem. It is unknown whether psychological factors modulate any observed variation in @entity2 perception. Thirty-seven @entity0 with chronic @entity4 ( @entity4 ; mean age 61.9 years, 29 @entity0 , 8 @entity0 ) were consecutively included in the study. @entity2 perception of a low energy test shock (60V, 0.1J) during internal cardioversion was assessed immediately following the stimulus. Before treatment @entity1 , @entity3 , somatization were evaluated. The @entity5 was perceived as hypalgesic in 15 (41%) @entity0 , as normalgesic in 10 (27%), and as @entity6 in 10 (32%) @entity0 . @entity2 threshold was significantly lower in @entity0 in which @entity4 was accidentally diagnosed (p < 0.029). Age, sex, and the level of education were equally distributed over the three @entity2 groups. The @entity2 threshold was not associated with @entity1 , @entity3 , or the @entity0 ' tendency to amplify benign bodily sensations. This study discloses a wide range of perceived @entity2 intensity caused by a homogenous intracardiac stimulation. @entity1 and @entity3 do not amplify perception of @entity5 . Sensory gating mechanisms may play a more important role in the level of @entity5 perception than distressing affective factors.

title: Absence of an impact of emotional distress on the perception of XXXX discharges.

answer: @entity5


abstract: OBJECTIVE: To analyze trends in the surgical management of @entity3 in Ontario over the past 2 decades. DESIGN: Retrospective analysis of health records. METHODS: Ontario Health Insurance Plan billing service claims between 1992 and 2012 were analyzed for the yearly number of @entity3 laser and incisional surgical procedures. The yearly number of Ontarians with @entity2 ( @entity2 ) was estimated by applying composite prevalence curves to published population data and the yearly number of procedures per 1000 Ontarians with @entity2 was calculated. RESULTS: Per 1000 @entity0 with @entity2 , laser trabeculoplasty (LT) rates increased nearly 2-fold (185%) from 1992 to 2012, with the rates stabilizing between 2008 and 2012, and total @entity3 filtration procedure (GFP) rates (trabeculectomy, aqueous shunts, and combined GFP and @entity1 extraction) in 2012 were similar to those in 1992, with a peak rate noted in 1996. Shunts represented 0.9% of GFP in 1992 and 33% in 2012. Data for combination codes billed on the same day for the same @entity0 were available from 2000. From 2000 to 2012 the rates of trabeculectomy alone remained unchanged, the number of aqueous shunts alone increased more than 5-fold, combined trabeculectomy and @entity1 extraction decreased 81%, whereas combined shunts and @entity1 extraction increased from 6 in 2000 to 420 in 2012. Combined aqueous shunts and @entity1 extraction represented 0.4% of combined @entity1 extractions in 2000 and 26.3% in 2012. CONCLUSIONS: Over the past 2 decades there was an overall increase in the rate of LT, no change in the rate of trabeculectomies, and a significant increase in aqueous shunt surgery.

title: Trends in XXXX surgical procedures in Ontario: 1992-2012.

answer: @entity3


abstract: PURPOSE: To describe corneal surface changes in @entity3 ( @entity3 ). METHODS: In all 23 @entity0 with @entity3 were examined with the slit lamp and photographed by non-contact photomicrography. RESULTS: Without staining, grey surface cells and small epithelial cysts were visible. Application of @entity2 resulted in two types of micropunctuate (15-30 microm) staining, a nonfluorescent (yellow/brown) and a fluorescent (green) one, in brilliantly green staining of cysts, and in enlarging fluorescent (green) flecks (70-1600 microm) with propensity to confluence. The flecks often developed in inconspicuous areas and showed abnormal subsurface cells. Application of rose bengal resulted in more or less intensively red-stained cells measuring about 30 mm in diameter, often less (15-20 microm), with or without a centrally located nucleus, individual or gathered in small groups or larger patches, and in confluent staining. Smaller and larger cells, with or without nuclei, weakly or strongly stained, were often located close to each other. The smaller green flecks showed a few centrally located red-stained cells, and the larger ones showed many almost uniform small red-stained nucleated ones. CONCLUSIONS: Corneal epithelial surface disease in the present @entity3 @entity0 consisted of unspecific features-such as increased light-reflecting property (grey cells), disruptions of intercellular junctions (micropunctuate green @entity2 staining), pathological dye uptake (micropunctuate yellow/brown @entity2 and red rose bengal stainings), and epithelial @entity1 (microcysts)--and also of features that seemed to be disease specific. Such features were, with @entity2 , focal disruptions of the epithelial barrier function manifesting in enlarging green flecks, and, with rose bengal, abundant nucleated cells, particularly small ones organised in foci. The nature of the abnormal subsurface cells present in the areas of the green flecks, and the mechanisms behind the focal involvement are unclear.

title: Corneal surface changes in XXXX . Part I: The surface proper. A non-contact photomicrographic in vivo study in the @entity0 cornea.

answer: @entity3


abstract: BACKGROUND: Anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty have been widely used to treat @entity0 with cervical spondylotic @entity3 and/or @entity4 . In our clinical practice, many @entity0 with @entity5 also complain of @entity1 , and wish to know if the surgical treatment for @entity5 can also alleviate this symptom. Considering that there is no literature concerning this extra benefit of surgical manipulation on @entity5 , we have carried out this retrospective study. METHODS: Among the @entity0 treated with anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty in our institute for cervical spondylotic @entity3 and/or @entity4 between February 2002 to March 2011, 108 of whom that have complained about @entity1 at the same time were included in this study. Those @entity0 were followed by 25 to 145  months. Severity of @entity1 before the surgery and at the last follow up was recorded by VAS @entity2 scores and compared among the @entity0 with different surgical methods using SPSS17.0 software. One way ANOVA was used to compare VAS scores between the groups, paired sample t-tests were used to compare the differences in a group at different time points. RESULTS: @entity1 was significantly alleviated in all groups (P   <   0.01). Respectively, 75.0  % of the @entity0 in the ACDF group, 84.6  % of the @entity0 in the TDR group and 82.2  % of the @entity0 in the laminoplasty group were significantly relieved of the @entity1 after the surgery. No significant differences were found with the VAS score at the last follow up among the groups (P   >   0.05). No significant differences were found among the groups comparing the degree of alleviation of VAS scores before and after the surgery (P   >   0.05). DISCUSSION: Considering that all the three procedures in the current study have achieved similar effect on alliviating @entity1 in @entity0 with cevical @entity3 , and that what they have in common was that was the decompression of spinal cord, it can be assumed that the @entity1 associated with @entity5 may be the result of compression on the spinal cord. CONCLUSIONS: Anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty can all significantly alleviate @entity1 in @entity0 with cervical spondylotic @entity3 and/or @entity4 . No surgical technique is better than any other technique on alleviating cervical @entity1 associated with cervical spondylotic @entity3 and/or @entity4 .

title: Effect of different surgical methods on @entity1 associated with cervical spondylotic XXXX and/or @entity4 .

answer: @entity3


abstract: UNASSIGNED: Dietary patterns with @entity1 have been recommended, but the relative contributions of individual foods and food components, alone or in combination, remain undefined. Male @entity10 (-/-) @entity0 were fed either a purified AIN-93G control diet, a @entity11 ( @entity11 ), or a @entity11 with 10% @entity3 powder (TP), 2% soy germ (SG), or the combination, for 4 wk (n = 10 per group). Plasma total @entity2 and @entity6 were measured with enzymatic colorimetric kits, and @entity14 ( @entity14 ) was measured by ELISA. Liver lipids were extracted with @entity9 : @entity5 , and @entity6 , free and esterified @entity2 measured with enzymatic colorimetric kits. Expression of @entity16 , @entity15 , @entity12 , and @entity13 in the liver was determined by quantitative polymerase chain reaction. Sections of the aortic root and aorta were cut and stained with @entity7 and @entity8 (H_E) to assess extent of @entity4 . @entity11 -fed animals had greater liver and adipose weights, plasma @entity2 and @entity14 , hepatic lipids, and @entity4 than AIN-93G animals. TP and SG did not decrease @entity4 as measured by H_E-stained sections of the aortic root, aortic arch, and descending aorta. The TP diets further increased plasma @entity2 , but also led to increased expression of the @entity12 /8 transporters involved in @entity2 efflux. Addition of SG alone to the @entity11 attenuated @entity11 -induced increases in plasma @entity2 , liver lipids, and gonadal adipose weight. The results of this study do not support the use of either TP or SG for reduction of @entity4 , but suggest some beneficial effects of SG on lipid metabolism in this model of @entity1 .

title: Effects of @entity3 and Soy Germ on Lipid Bioaccumulation and @entity4 in XXXX (-/-) @entity0 .

answer: @entity10


abstract: BACKGROUND: Neuropathies associated with @entity5 (NAL) are rare and present a great clinical heterogeneity, making them difficult to diagnose and worsening their prognosis. OBJECTIVES: (1) To report the different patterns of NAL and discuss the mechanisms encountered; (2) to determine the relationship between a given type of @entity5 and a specific @entity1 ; and (3) to assess the prognosis of NAL. METHODS: Among 150 @entity0 with @entity5 and @entity1 , we selected 26 in whom the @entity1 was not related to drug induced or IgM-antimyelin associated @entity1 . The pattern of @entity1 was defined in terms of its clinical and electrophysiological features. Neurological improvement, haematological remission and occurrence of @entity2 were taken into account to determine the prognosis. RESULTS: 13 @entity0 (50%) had a demyelinating @entity3 ( @entity3 ), seven (27%) had a @entity4 linked to proximal root tumoral infiltration and six (23%) had an @entity8 (MM) related to @entity7 or to @entity9 . @entity6 was only associated with demyelinating @entity3 . High grade B cell @entity5 was strongly associated with @entity4 . Neurological improvement was observed in 69% of @entity0 with demyelinating @entity3 , 29% with @entity4 and 50% with MM. Haematological remission was observed in 46% of @entity0 with demyelinating @entity3 , 29% with @entity4 and 83% with MM. CONCLUSIONS: Demyelinating @entity3 , the most frequently observed @entity1 in this study, had the best neurological prognosis. Chemotherapy combined with immune mediated treatment was the most effective treatment in this group. Identifying the type and mechanism of NAL is crucial in order to define the therapeutic strategy and improve the prognosis.

title: XXXX : a relationship between the pattern of @entity1 , type of @entity5 and prognosis?

answer: @entity5


abstract: BACKGROUND: Large comparative studies that have evaluated long-term functional outcome of operatively treated @entity4 are lacking. This study was performed to analyse the influence of several combinations of @entity2 on long-term functional outcome and development of @entity3 . METHODS: Retrospective cohort-study on operated (1995-2007) @entity2 . Results were assessed with use of the AAOS- and AOFAS-questionnaires, VAS- @entity1 score, dorsiflexion restriction (range of motion) and @entity3 . Categorisation was determined using the number of malleoli involved. RESULTS: 243 @entity0 with a mean follow-up of 9.6  years were included. Significant differences for all outcomes were found between unimalleolar (isolated fibular) and bimalleolar (a combination of fibular and medial) @entity2 (AOFAS 97 vs 91, p   =   0.035; AAOS 97 vs 90, p   =   0.026; dorsiflexion restriction 2.8   vs 6.7  , p   =   0.003). Outcomes after fibular @entity2 with an additional posterior fragment were similar to isolated fibular @entity2 . However, significant differences were found between unimalleolar and trimalleolar (a combination of lateral, medial and posterior) @entity2 (AOFAS 97 vs 88, p   <   0.001; AAOS 97 vs 90, p   =   0.003; VAS- @entity1 1.1 vs 2.3 p   <   0.001; dorsiflexion restriction 2.9   vs 6.9  , p   <   0.001). There was no significant difference in isolated fibular @entity2 with or without additional deltoid ligament injury. In addition, no functional differences were found between bimalleolar and @entity4 . Surprisingly, poor outcomes were found for isolated @entity2 . Development of @entity3 occurred mainly in @entity4 with a posterior fragment larger than 5  %. CONCLUSIONS: The results of our study show that long-term functional outcome is strongly associated to @entity2 , isolated or as part of bi- or @entity4 . More cases of @entity3 are found in @entity4 .

title: Long-term functional and radiographic outcomes in 243 operated XXXX .

answer: @entity4


abstract: BACKGROUND: The clinical diagnosis is often subjective and susceptible to bias, yet it is the primary standard by which diagnostic tests are judged. Consequently, our opinions regarding various diagnostic tests may not be entirely accurate. OBJECTIVE: To investigate the accuracy of the clinical history compared with concordant skin and quantitative specific IgE (s-IgE) measurements. METHODS: Consecutive, consenting @entity0 (N = 152) at 2 different @entity1 centers were examined by @entity2 ( @entity2 ) alone to determine their sensitivity to 7 common allergens. Results were classified as positive, negative, or indeterminate. The @entity2 results were then compared to concordant skin prick testing (SPT) and s-IgE measurements and to quantitative IgE antibody measurements with and without knowledge of the SPT results. RESULTS: Diagnosis by @entity2 deviated considerably from concordant SPT and s-IgE results. This deviation differed between allergists and allergens, reflecting a positive @entity2 bias that averaged 22%. Seventy-six percent of the @entity2 results judged indeterminate were resolved as negative. Using additional information from the quantification of s-IgE antibodies, considerable differences between the sites in the level of s-IgE associated with a positive @entity2 result with and without SPT results were observed. CONCLUSIONS: Relative to the SPT and quantification of s-IgE antibodies, the diagnosis by @entity2 alone to common allergens is not consistent. Discrepancies were dependent on both allergen and allergist. The quantitative s-IgE data revealed that allergists use available information from the @entity2 and SPT differently. Since the @entity2 is the primary standard used in judging test efficacy (sensitivity and specificity), our current impressions of test performances are not likely to be accurate.

title: Are our impressions of XXXX test performances correct?

answer: @entity1


abstract: BACKGROUND: The altered hemodynamics, and therefore the arterial @entity4 is the most prevalent adverse effect after @entity3 . The objective of the study was to determine the exact role of local anesthetic selection underlying spinal anesthesia-induced @entity4 in the elderly @entity0 . We conducted a descriptive, observational pilot study to assess the hemodynamic impact of @entity3 with isobaric @entity7 versus hyperbaric @entity6 for @entity2 surgery. DESCRIPTION: Hundred twenty ASA status I-IV @entity0 aged 65 and older undergoing @entity2 surgery were enrolled. The primary objective of our study was to compare hemodynamic effects based on systolic blood pressure (SBP) and dyastolic blood pressure (DBP) values, heart rate (HR) and hemoglobin (Hb) and respiratory effects based on partial @entity1 saturation (SpO2%) values. The secondary objective was to assess potential adverse events with the use of @entity7 versus @entity6 . Assessments were performed preoperatively, at 30 minutes into surgery, at the end of anesthesia and at 48 hours and 6 months after surgery. Among intraoperative events, the incidence of @entity4 was statistically significantly higher (p <0.05) in group BUPI (38.3%) compared to group LEVO (13.3%). There was a decrease (p <0.05) in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 30 minutes intraoperatively (19% in group BUPI versus 17% in group LEVO). SpO2% increased at 30 minutes after anesthesia onset (1% in group BUPI versus 1.5% in group LEVO). Heart rate (HR) decreased at 30 minutes after anesthesia onset (5% in group BUPI versus 9% in group L). Hemoglobin (Hb) decreased from time of operating room (OR) admission to the end of anesthesia (9.3% in group BUPI versus 12.5% in group LEVO). The incidence of red blood cell (RBC) transfusion was 13.3% in group BUPI versus 31.7% in group LEVO, this difference was statistically significant. Among postoperative events, the incidence of @entity5 ( @entity5 ) was significantly higher in group BUPI (8,3%). At 6 months after anesthesia, no differences were found. CONCLUSIONS: Given the hemodynamic stability and lower incidence of intraoperative @entity4 observed, @entity7 could be the agent of choice for @entity3 in elderly @entity0 .

title: Hemodynamic impact of isobaric XXXX versus hyperbaric @entity6 for @entity3 in @entity0 aged 65 and older undergoing hip surgery.

answer: @entity7


abstract: @entity10 ( @entity10 ) is a @entity4 characterized by diffuse @entity0 , @entity5 , a @entity2 that is usually occipital encephalocele, and/or vermian agenesis, with intrahepatic biliary duct proliferation. @entity7 ( @entity7 ) is a viable @entity1 with a characteristic "molar tooth sign" (MTS) on axial images reflecting @entity8 / @entity3 . Both conditions are classified as ciliopathies with an autosomal recessive mode of inheritance. Allelism of @entity10 and @entity7 has been reported for @entity11 / @entity11 , @entity6 / @entity6 , and @entity12 / @entity12 . Recently, one homozygous splice mutation with a founder effect was reported in the @entity9 gene in Finnish fetuses with @entity10 , defining the 6th locus for @entity10 . Shortly thereafter, @entity9 mutations were also reported in @entity7 . The analysis of the @entity9 gene in our series of @entity10 fetuses, identified 14 novel truncating mutations in 11 cases. These results confirm the involvement of @entity9 in @entity10 and reveal a major contribution of @entity9 to the disease. We also identified three missense @entity9 mutations in two @entity7 cases. Therefore, and in accordance with the data reported regarding @entity12 , our results indicate phenotype-genotype correlations, as missense and presumably hypomorphic mutations lead to @entity7 while all null alleles lead to @entity10 .

title: XXXX mutations in Meckel and Joubert syndromes indicate a genotype-phenotype correlation.

answer: @entity9


abstract: UNASSIGNED: We aimed to identify and characterize subtypes of @entity2 ( @entity2 ) exhibiting different patterns of regional @entity4 on MRI using age- and gender-specific norms of regional brain volumes. @entity2 subjects included in the @entity2 Neuroimaging Initiative study were classified into subtypes based on standardized values (Z-scores) of hippocampal and regional cortical volumes on MRI with reference to age- and gender-specific norms obtained from 222 cognitively normal (CN) subjects. Baseline and longitudinal changes of clinical characteristics over 2 years were compared across subtypes. Whole-brain-level gray matter (GM) @entity1 pattern using voxel-based morphometry (VBM) and cerebrospinal fluid (CSF) biomarkers of the subtypes were also investigated. Of 163 @entity2 subjects, 58.9% were classified as the "both impaired" subtype with the typical hippocampal and @entity1 pattern, whereas 41.1% were classified as the subtypes with @entity1 patterns: "hippocampal @entity1 only" (19.0%), " @entity1 only" (11.7%), and "both spared" (10.4%). Voxel-based morphometric analysis demonstrated whole-brain-level differences in overall GM @entity1 across the subtypes. These subtypes showed different progression rates over 2 years; and all subtypes had significantly lower CSF amyloid-b1-42 levels compared to CN. In conclusion, we identified four @entity2 subtypes exhibiting @entity1 patterns on MRI with different progression rates after controlling the effects of aging and gender on @entity1 with normative information. CSF biomarker analysis suggests the presence of Ab neuropathology irrespective of subtypes. Such heterogeneity of MRI-based @entity3 biomarker and related heterogeneous progression patterns should be considered in clinical trials and practice with @entity2 @entity0 .

title: Heterogeneity of Regional Brain Atrophy Patterns Associated with Distinct Progression Rates in XXXX .

answer: @entity2


abstract: We studied the @entity2 and efficacy of adding to @entity10 five resistance modulators in the treatment of resistant solid @entity1 . Additional drugs were added in successive cohorts of @entity0 , such that cohort 1 @entity0 received two drugs along with their @entity10 , while cohort 4 @entity0 received five modulators along with their @entity10 . @entity9 , @entity8 (cohort 1), @entity14 (cohort 2), @entity13 (cohort 3) and @entity4 (cohort 4) were administered with @entity10 . A total of 22 @entity0 were treated. @entity6 and @entity7 was usually mild to moderate. There was an unexpectedly high incidence of possible @entity11 associated with treatment, although in some @entity0 it was uncertain whether or not observed @entity5 were related to treatment. @entity12 was significant in all four cohorts, but it was unclear whether it was increased by the modulators. There were two febrile neutropenic events in cohorts 1 and 2 successfully treated with antibiotics, and three @entity3 (one in each of cohorts 1, 2 and 4). It was elected to discontinue enrollment on the study prematurely in light of cardiac and other @entity2 seen in the first two @entity0 accrued in cohort 4. A single response was observed. While this approach is feasible, the observed @entity2 and the difficulty @entity0 experienced in ingesting the large number of prescribed pills will make further exploration of this approach difficult.

title: Pilot study of multiple chemotherapy resistance modulators plus @entity10 in the treatment of resistant XXXX .

answer: @entity1


abstract: Inability to breathe through the nose is an increasingly recognized cause of @entity5 . To test the hypothesis that this @entity6 could result from loss of neuronal input to respiration from receptors located in the nose, we anesthetized the nasal passages of 10 normal @entity0 during sleep. Each subject spent 4 consecutive nights in the sleep laboratory while sleep stages, @entity7 patterns, respiratory effort, and arterial @entity2 saturation were monitored. Night 1 was for acclimatization with Nights 3 and 4 being randomized to nasal spraying with either 4% @entity8 or placebo. On the @entity8 and placebo nights (Nights 3 and 4) the nasal passages were also sprayed with a decongestant to prevent increased nasal air-flow resistance resulting from @entity1 . To control for the possible effects of this decongestant, an additional night (Night 2) was included during which the nasal passages were sprayed with room air. Parallel studies conducted during wakefulness demonstrated low nasal resistance during the @entity8 -decongestant regimen. Because of the short duration of anesthesia with @entity8 , spraying was done at lights out and 2.5 and 5 h later. On the placebo night (decongestant plus saline) there were 6.4 +/- 1.8 (SEM) disordered @entity7 events ( @entity3 ) per subject, whereas with @entity8 (plus decongestant) this increased fourfold to 25.8 +/- 7.8 events per subject (p less than 0.05). The majority of the disordered @entity7 events were @entity4 and were fairly evenly distributed between central and obstructive events. The magnitude of these changes is similar to that previously reported with complete nasal obstruction. These results suggest that nasal receptors sensitive to air flow may be important in maintaining @entity7 rhythmicity during sleep.

title: The effects of nasal anesthesia on XXXX during sleep.

answer: @entity7


abstract: UNASSIGNED: @entity7 is a major bioactive constituent isolated from Anoectochilus formosanus and is investigated as an antihyperlipidemic candidate. In this study, a rapid, sensitive, and reliable bioanalytical method was developed for the determination of @entity7 in @entity1 plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC- @entity0 / @entity0 ). The plasma sample was pretreated with 1% @entity4 , followed by protein precipitation with @entity5 : @entity2 (70:30). Chromatographic separation was performed on a HILIC @entity6 column (2.1mm*100mm, 3 m). The mobile phases consisted of 0.1% @entity4 in distilled water (solvent A) and 0.1% @entity4 in @entity5 (solvent B). A gradient program was used at a flow rate of 0.2mL/min. For mass spectrometric detection, the multiple reaction monitoring mode was used; the MRM transitions were m/z 265.2 > m/z 102.9 for @entity7 and m/z 163.3 > m/z 132.1 for the internal standard (IS) @entity3 in the positive ionization mode. A calibration curve was constructed in the range of 2-500ng/mL. The intra- and interday precision and accuracy were within 5%. The HILIC- @entity0 / @entity0 method was specific, accurate, and reproducible and was successfully applied in a pharmacokinetic study of @entity7 in @entity1 .

title: Development of a hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the determination of @entity7 , an antihyperlipidemic candidate, in XXXX plasma and its application to pharmacokinetic studies.

answer: @entity1


abstract: @entity1 /chronic @entity2 ( @entity3 /CPPS) causes substantial morbidity afflicting approximately 10% of adult males. Treatment is often empirical and ineffective since the etiology is unknown. Other prostate and @entity5 have genetic components suggesting that @entity3 /CPPS may also be influenced by genetic predisposition. We recently reported a highly polymorphic short tandem repeat (STR) locus near the phosphoglycerate kinase gene within Xq11-13. Because this STR is in a region known to predispose towards other @entity4 , we compared STR polymorphisms in 120 @entity3 /CPPS @entity0 and 300 control blood donors. Nine distinct allele sizes were detected, ranging from 8 to 15 repeats of the tetrameric STR plus a mutant allele (9.5) with a six base deletion in the flanking DNA sequence. The overall allele size distribution in the @entity3 /CPPS @entity0 differed from controls (Chi-square=19.252, df=8, P=0.0231). Frequencies of two specific alleles, 9.5 and 15, differed significantly in @entity3 /CPPS vs. control subjects and allele 10 differed with marginal significance. Alleles 9.5 and 10 were both more common in @entity3 /CPPS @entity0 than controls while allele 15 was less common. These observations suggest that Xq11-13 may contain one or more genetic loci that predispose toward @entity3 /CPPS. Further investigations involving family studies, larger @entity0 populations, and other control groups may help elucidate this potential genetic predisposition in @entity3 /CPPS.

title: X Chromosomal short tandem repeat polymorphisms near the phosphoglycerate kinase gene in @entity0 with chronic XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the safety of withholding anticoagulation in @entity0 with suspected @entity3 after negative multislice computed tomography (MSCT) pulmonary angiography and lower-limb venography. MATERIALS AND METHODS: A total of 383 consecutive @entity0 with suspected @entity3 were prospectively studied. @entity0 underwent MSCT pulmonary angiography and lower-limb venography, as well as pulmonary scintigraphy and lower-limb ultrasound examination. @entity0 with negative MSCT results for both @entity3 and @entity1 were not administered anticoagulants and were followed up for 6 months to rule out @entity2 . RESULTS: At MSCT, 156 @entity0 were positive for @entity3 , @entity1 , or both; 224 were negative; and findings were inconclusive in three. False-negatives were five @entity0 with high probability scintigram and two with @entity1 detected at US. A total of 184 @entity0 with negative MSCT and without anticoagulation were followed up for 6 months. During this period of time just one recurrence of @entity3 was detected. The negative predictive value of MSCT pulmonary angiography plus lower-limb venography was 95.8% (183/191). CONCLUSION: MSCT is efficacious in diagnosing @entity3 , with negative predictive values reported in the literature ranging from 94% to 100%. This enables omission of anticoagulation in @entity0 with suspected @entity3 after negative MSCT findings without the need for other diagnostic tests.

title: Can multislice CT alone rule out reliably XXXX ? A prospective study.

answer: @entity3


abstract: Oncogenic HPV types are the major @entity1 , but only a small proportion of infected @entity0 will develop high-grade cervical @entity7 or @entity1 (CIN2/3+). We performed a prospective study including 781 @entity0 with normal, atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous @entity3 (LGSIL) cytology, and infected or not by high-risk (HR) HPV tested by Hybrid Capture II. @entity0 were followed up every 6 months for a median period of 22 months. Among the HR-HPV-positive @entity0 at entry, more than half cleared their virus in 7.5 months; the clearance rate was greater for low viral loads than for high loads and also was higher in @entity0 with an initial ASCUS/LGSIL smear than in @entity0 with normal cytology. The incidence of cytologic abnormalities strongly depended on baseline @entity6 persistence. Maintenance of cytologic abnormalities was associated with the outcome of HR-HPV status (negative<transient<persistent) but not with baseline load. Progression to CIN2/3+ was achieved only in @entity0 with persistent @entity4 . The risk of CIN2/3+ also was increased with initial high loads (> or =100 pg/mL). Conversely, @entity0 who were consistently HR-HPV negative or transiently HR-HPV positive, whatever the cytology at baseline was, did not develop CIN2/3+ during follow-up. Age seemed to affect only the rate of @entity4 . In conclusion, our data suggest that @entity0 repeatedly tested positive for HR-HPV are at risk of developing CIN2/3+, even when initial cytology is normal. A high viral load could be used as a short-term marker of progression toward @entity5 , although lower load does not inevitably exclude @entity2 .

title: Persistence and load of high-risk HPV are predictors for development of high-grade XXXX : a longitudinal French cohort study.

answer: @entity3


abstract: OBJECTIVES: There is currently a lack of recommendations about @entity0 with @entity1 requiring cardiac surgery. This study reports the results of our surgical strategy on this issue. METHODS: Eleven @entity0 , from three centers treated over a 9-year period were included in this study. @entity1 were operated with a modified Ravitch procedure. In the case of @entity2 repair and concomitant cardiac surgery, subperichondrial resection of abnormal rib cartilages was always performed before the sternotomy and an easily removable retrosternal metallic strut was inserted at the end of the procedure ensuring anterior chest wall stability. During follow-up @entity0 had to estimate their current appearance with a numeric scale ranging from 0 to 100. RESULTS: Mean age was 27    9.4 years. @entity2 was present in 8 @entity0 and pectus arcuatum in 3. There were 6 @entity3 @entity0 . Nine @entity0 had concomitant surgery and, 2 underwent pectus repair after a history of cardiac surgery. There was no operative mortality. In the case of concomitant surgery, heart exposure through median sternotomy was facilitated by abnormal rib cartilage resection. Median follow-up was 54 months (range 16.7-119.7). Mean cosmetic result evaluated by the @entity0 was 97.3 (  2.5). CONCLUSIONS: In adults, concomitant scheduled surgery is reliable and offers excellent long-term cosmetic results. Moreover, it allows a better thoracic exposition with no added perioperative risk. The modified Ravitch technique seems more adequate in these @entity0 as it can be used in all types of @entity1 .

title: Cardiac surgery and repair of XXXX : When and how?

answer: @entity1


abstract: OBJECTIVES: In this study, we have established an in vitro three-dimensional (3D) coculture, where normal endometrial stromal cells and @entity4 cells were cocultured under defined hormonal conditions, to investigate the potential paracrine effects on synthesis and secretion of matrix metalloproteinases (MMPs) and, thus, @entity1 . METHODS: Endometrial stromal cells were obtained by biopsy, cultured in the presence of 100 nM @entity2 for 3 days, and then mixed with extracellular matrix (ECM) composed of collagen I and matrigel in a 4:1 ratio. After 3 more days in culture, a 3D coculture was established with @entity0 cells, an @entity4 cell line, grown on top of the mixture under various ovarian @entity3 (no steroid, 100 nM @entity9 (E2), or 1.0 microM @entity5 (P4)) for 10 days. The expression and localization of @entity7 , @entity8 , and @entity6 subunit were visualized by immunocytochemistry and analyzed by reverse transcription polymerase chain reaction (RT-PCR). The extent of @entity1 was quantified by Boyden's chamber assay. RESULTS: @entity6 subunit was localized along the cell surface of @entity0 cell under all three hormonal conditions. @entity7 was located in the cytoplasm of stromal cells and on the surface of @entity0 cells. Synthesis and secretion of stromal @entity7 were increased in the presence of ovarian @entity3 . In contrast, expression of stromal @entity8 was suppressed in the presence of ovarian @entity3 . No MMPs were synthesized in @entity0 cells. Invasion assay revealed that @entity0 cells achieved high tumoral invasiveness in the presence of @entity9 . CONCLUSIONS: These findings suggest that stromal cell-derived @entity7 is translocated to the surface of @entity0 cells. @entity6 subunit might contribute, in part, to providing a binding site for @entity7 . Thus, @entity0 cells invade by recruiting @entity7 secreted by stromal cells, which is greatly enhanced in the presence of @entity9 . The 3D coculture provides an excellent experimental system in which single parameters can be isolated from a complex in vivo system in the process of @entity4 .

title: Localization of matrix metalloproteinases on XXXX cell invasion in vitro.

answer: @entity4


abstract: OBJECTIVE: To retrospectively evaluate the technical feasibility and midterm results of uncovered thoracoabdominal stent placement in complicated acute @entity4 Stanford type B (cAADB). @entity0 AND METHODS: Fourteen consecutive @entity0 (3 females; range, 44-71 years) with cAADB who had symptomatic @entity2 and claudication underwent immediate uncovered stent implantation (diameter, 7-28 mm; length, 40-100 mm) into the true lumen of the thoracoabdominal aorta (n = 23) and visceral arteries (n = 5). RESULTS: Stenting resulted in elimination of @entity2 and symptoms in 13 of 14 @entity0 ; persisting symptoms led to secondary surgical revascularization in only 1 @entity0 . More than 1 stent ( <= 4) was placed in 7 @entity0 (2 celiac, 1 mesenteric, 2 renal, 8 aorto-iliac). Follow-up computed tomographic angiography (CTA) revealed collapse of 4 aortic stents (diameter, 9-25 mm; length, 100 mm) at 1 week in the absence of symptoms. Balloon reexpansion was possible in all 4 stents, but recollapse occurred within 1 month. Despite stent collapse, the @entity0 remained asymptomatic; ultrasonography and CTA documented sufficient perfusion of the visceral arteries in all @entity0 . Follow-up ranged from 6 months to 5 years (average, 2.5 years). Except for the @entity0 who underwent iliacomesenteric bypass for unspecific @entity3 , no other @entity0 required additional interventional or surgical therapy. CONCLUSIONS: Acute @entity4 with suspicion of @entity1 should prompt for immediate intervention. Thoracoabdominal uncovered stent implantation is a technically feasible and effective minimally invasive approach that provided successful relief of acute @entity1 and claudication in cAADB. Stent size should be less than the normal aortic diameter to avoid possible stent collapse.

title: Uncovered stent implantation in complicated acute XXXX type B.

answer: @entity4