abstract: OBJECTIVE: To retrospectively evaluate the efficacy of high-dose-rate brachytherapy of @entity6 with a special focus on analysis of @entity2 . STUDY DESIGN: Twenty consecutive @entity0 were irradiated with brachytherapy of @entity6 with component ca in situ (N=3). Late complications of the vagina graded using the CTCAE v.3.0. General assessment three-step scale was introduced for simplicity of analysis. RESULTS: The median age was 57 years (range: 28-80 years). The median follow-up time was 39 months (range: 14-115 months). @entity6 recurrence was observed in 1 @entity0 . The 3-year disease free survival rate was 90% (95% confidence interval [CI]: 71-100%). Observed late side effects: libido grades 1-2 in 15 (75%), vaginal discharge grade 2 (pad use indicated) in 2 (10%), @entity5 ( @entity3 ) in 7 (35%), @entity1 grades 2-3 in 6 (30%), @entity4 grades 2-3 in 7 (35%) and vaginitis grades 2-3 in 4 (20%) cases. General assessment was good in 9 (45%), average in 2 (10%), and bad in 9 (45%) @entity0 . Treatment dose affected the @entity2 (p=0.05). In groups of @entity0 irradiated with biologically equivalent dose (assuming a/b=3Gy) of 47.3-63Gy and >= 70Gy, the risk of poor or moderate @entity2 amounted to 16.7% (95% CI: 0-47%) and 71.4% (95% CI: 48-95%), respectively. CONCLUSION: Brachytherapy revealed to be effective method of @entity6 treatment, but applying EQD2>= 70Gy into vagina generates unacceptable @entity2 .

title: Brachytherapy for XXXX .

answer: @entity6


abstract: UNASSIGNED: 561 Background: Mutations in @entity0 gene 1 and 2( @entity5 ) account for 50% of the @entity3 . About one third of the mutations are of unknown pathogenetic relevance (unclassified variants, UCV). We recently identified @entity9 as a third high penetrance gene (Meindl et al., 2010). Like @entity5 , @entity9 is also involved in homologous recombination repair (HRR) in response to DNA double strand breaks. It has recently been shown that cells with @entity7 are sensitive to synthetic lethality mediated by @entity6 inhibition. Under the assumption that further high risk genes may exist which acts through the HRR pathway we aimed to develop a reliable functional test system which allows the evaluation of @entity7 in heterozygous carriers. METHODS: We included eight carriers of a pathogenic @entity2 mutation, two carriers of a pathogenic @entity9 mutation and nine healthy controls as well as seven @entity2 UCV carriers. @entity1 and control lymphocytes were y-irradiated in G2 phase to introduce DNA-DSB. For the assessment of HRR capacity, metaphase chromosomes were stained by multicolour fluorescence in situ hybridisation ( @entity8 ). Chromosomal translocations and breakages were counted per mitosis and referred to total chromosomal number. The aberration frequency of @entity2 and @entity9 carriers versus the controls was compared. RESULTS: Lymphocytes from @entity2 and @entity9 pathogenic mutation carriers versus controls showed a mean aberration frequency of 2.51  0.36 (standard deviation, SD) and 2.7  0.25 (SD), respectively, versus 1.4  0.44 (SD) chromosomal aberrations per metaphase with no overlap (p-value <0.001; Student's t-test). Seven @entity1 carrying an UCV in @entity2 could be allocated to either the pathogenic or the control group. CONCLUSIONS: Our test system allows the detection of @entity7 in heterozygous lymphocytes of @entity2 and @entity9 gene mutation carriers and is currently evaluated in @entity4 positive cases. The assay may enable the identification of @entity7 irrespective of the underlying gene defect and may also serve as a biomarker for sensitivity to @entity6 inhibition.

title: A functional assay for the identification of DNA double-strand break repair deficiency in heterozygous carriers of @entity5 and XXXX mutations.

answer: @entity9


abstract: UNASSIGNED: 465^ Background: Multiple targeted therapies have become available for @entity4 over the past decade. @entity6 is an orally active multikinase inhibitor which has been shown to improve progression free survival in low-risk and intermediate-risk status advanced clear-cell @entity4 after previous systemic therapy. METHODS: Between May 2006 and December 2010, @entity0 with advanced @entity4 with either clear cell or non-clear cell histopathology who had progressed on prior systemic chemotherapy or were treatment na  ve, ECOG performance status 0-2, commenced treatment with @entity6 (400-mg twice daily continuously) through an expanded access clinical trial in two tertiary centres in Sydney and Melbourne. We report the pooled outcomes of these two studies. RESULTS: Total 47 @entity0 with metastatic @entity4 were treated with @entity6 . The median overall survival of advanced @entity4 was 11.9 months. After median follow up of 51.3 months, the median PFS was 6.5 months. 38 @entity0 died by the time of analysis. Overall 1 @entity0 showed complete response (CR), 6 @entity0 (13%) had partial response (PR), and 29 @entity0 (62%) had stable disease (SD) as the best response. 8 (17%) had non-clear cell histopathology and 5 (10%) had sarcomatoid features. In non-clear cell cohort, 5 @entity0 (62.5%) showed SD. 23 (49%) @entity0 were treatment na  ve; 1/23 showed CR, 5/23 had PR and 13/23 had SD (clinical benefit: 83%). Overall 14 (30%) and 22 (47%) @entity0 had high risk status according to MSKCC and Heng prognostic scores, respectively. Median PFS for poor prognostic @entity0 was 5.1 and 4.2 months based on MSKCC and Heng scores, respectively. In MSKCC poor prognostic group, 1 @entity0 had CR, 2/14 showed PR and 8/14 had SD (clinical benefit: 79%). In Heng poor prognostic group, one @entity0 had CR, 2/22 showed PR and 13/22 had SD (clinical benefit: 73%). @entity6 -related serious adverse events were seen in 10 @entity0 . The most common adverse events were @entity7 (53%), @entity5 (47%), @entity3 (42%), @entity2 (40%), and @entity1 (32%). CONCLUSIONS: This study confirms the efficacy and tolerability of @entity6 in a different spectrum of advanced @entity4 @entity0 including non-clear cell histology, poor prognostic status and as first-line treatment. CLINICAL TRIAL INFORMATION: ACTRN12606000140550.

title: Efficacy of @entity6 in advanced @entity4 ( XXXX ) independent of prior treatment, histology, or prognostic group.

answer: @entity4


abstract: BACKGROUND: Fear of reinjury and lack of confidence influence return-to-sport outcomes after anterior cruciate ligament (ACL) reconstruction. The physical, psychosocial, and functional recovery of @entity0 reporting fear of reinjury or lack of confidence as their primary barrier to resuming sports participation is unknown. PURPOSE: To compare physical impairment, functional, and psychosocial measures between subgroups based on return-to-sport status and fear of reinjury/lack of confidence in the return-to-sport stage and to determine the association of physical impairment and psychosocial measures with function for each subgroup at 6 months and 1 year after surgery. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: @entity1 (quadriceps index [QI], quadriceps strength/body weight [QSBW], hamstring:quadriceps strength ratio [HQ ratio], @entity2 intensity), self-report of function ( @entity4 [ @entity4 ]), and psychosocial (Tampa Scale for Kinesiophobia-shortened form [TSK-11]) measures were collected at 6 months and 1 year after surgery in 73 @entity0 with ACL reconstruction. At 1 year, subjects were divided into "return-to-sport" (YRTS) or "not return-to-sport" (NRTS) subgroups based on their self-reported return to preinjury sport status. @entity0 in the NRTS subgroup were subcategorized as NRTS-Fear/Confidence if fear of reinjury/lack of confidence was the primary reason for not returning to sports, and all others were categorized as NRTS-Other. RESULTS: A total of 46 subjects were assigned to YRTS, 13 to NRTS-Other, and 14 to NRTS-Fear/Confidence. Compared with the YRTS subgroup, the NRTS-Fear/Confidence subgroup was older and had lower QSBW, lower @entity4 score, and higher TSK-11 score at 6 months and 1 year; however, they had similar @entity2 levels. In the NRTS-Fear/Confidence subgroup, the @entity4 score was associated with QSBW and @entity2 at 6 months and QSBW, QI, @entity2 , and TSK-11 scores at 1 year. CONCLUSION: @entity2 -related fear of movement/reinjury, @entity3 , and reduced @entity4 score distinguish @entity0 who are unable to return to preinjury sports participation because of fear of reinjury/lack of confidence. Despite low average @entity2 ratings, fear of @entity2 may influence function in this subgroup. Assessment of fear of reinjury, quadriceps strength, and self-reported function at 6 months may help identify @entity0 at risk for not returning to sports at 1 year and should be considered for inclusion in return-to-sport guidelines.

title: XXXX , Functional, and Psychosocial Measures Based on Fear of Reinjury/Lack of Confidence and Return-to-Sport Status After ACL Reconstruction.

answer: @entity1


abstract: The gastric pathogen @entity0 forms biofilms on abiotic and biotic surfaces. We have shown previously that @entity0 perceives the quorum signal @entity1 ( @entity1 ) as a chemorepellent. We report here that @entity0 chemorepulsion from endogenous @entity1 influences the proportions and spatial organization of cells within biofilms. Strains that fail to produce @entity1 (   luxS strains) or are defective for @entity2 (   cheA strains) formed more spatially homogenous biofilms with a greater proportion of adherent versus planktonic cells than wild-type biofilms. Reciprocally, a strain that overproduced @entity1 (luxS(OP)) formed biofilms with proportionally fewer adherent cells. Along with the known @entity1 chemoreceptor, TlpB, we identified AibA and AibB, two novel periplasmic binding proteins that are required for the @entity1 chemorepulsion response. Disruptions in any of the proteins required for @entity1 @entity2 recapitulated the biofilm adherence and spatial organization phenotype of the    luxS mutant. Furthermore, exogenous administration of @entity1 was sufficient to decrease the proportion of adherent cells in biofilms and promote dispersal of cells from biofilms in a @entity2 -dependent manner. Finally, we found that disruption of @entity1 production or @entity1 @entity2 resulted in increased clustering of cells in microcolonies on cultured epithelial cells. We conclude that @entity2 from @entity1 is a determinant of @entity0 biofilm spatial organization and dispersal. IMPORTANCE: Bacterial biofilms are ubiquitous in nature, but the mechanisms governing their assembly and spatial organization are not fully understood. Bacterial communication through quorum sensing has been shown to influence biofilm growth through the regulation of biofilm genes. Our study revealed a new role for quorum sensing in biofilms through rapid chemotactic responses to quorum signals. Specifically, we studied how chemorepulsion of @entity0 from the universal quorum signal @entity1 ( @entity1 ) shapes the spatial organization of its biofilms. We demonstrate that the chemorepulsive response of @entity0 to @entity1 is necessary to promote its dispersal from biofilms grown on both abiotic and biotic surfaces and is sufficient to promote dispersal in a @entity2 -dependent manner. This work has broad implications for understanding the mechanisms by which endogenously produced microbial compounds shape the assembly and spatial organization of microbial communities in their environments.

title: Chemorepulsion from the Quorum Signal Autoinducer-2 Promotes XXXX Biofilm Dispersal.

answer: @entity0


abstract: BACKGROUND: Mistletoe extracts are widely used in @entity1 @entity0 due to their cytostatic and immunomodulatory effects. Essential components include mistletoe lectins which act as biomodulators with proinflammatory and apoptosisinducing effects. This study investigates the acute and longterm effects of standardized mistletoe extract (Iscador(R) M spec 5 mg) on thymocyte subpopulations and peripheral T-cells using a @entity2 (Balb/c) model. MATERIALS AND METHODS: Using cell surface @entity4 /CD8 staining and flow cytometry, we followed the changes in @entity4 -CD8- @entity7 ( @entity7 ), @entity4 (+)CD8(+) double-positive (DP) and @entity4 (+) or CD8(+) single-positive (SP) T-cells 24 h after single or repeated injections of 3 different dilutions (1:12, 1:60, 1:300) corresponding to 2.1, 0.42 and 0.08 mg/kg of Iscador. Thymocyte apoptosis was detected by flow cytometry using @entity6 and @entity5 . RESULTS: 24 h after a single injection of the 2 lower doses, the number of @entity7 thymocytes increased significantly with an enhanced ratio of apoptotic cells. Following administration of the lowest dose, in peripheral blood the @entity4 (+)/CD8(+) ratio was elevated. In the long-term trial, Balb/c @entity2 were treated twice a week with 3 different doses of Iscador +/- 20 mg/kg of @entity3 (DX), resulting in significantly enhanced @entity7 thymocytes and elevated levels of apoptotic cells after treatment with the 2 lower doses. Iscador also inhibited the DX-induced reduction in the thymic @entity7 cell count, as well as the DX-induced decrease in the @entity4 (+)/CD8(+) ratio and @entity4 (+) in the peripheral blood. CONCLUSION: Our results suggest that standardized mistletoe extract modulates proliferation and apoptosis of thymocytes in a dose-dependent manner and may act lymphoprotective during DX treatment.

title: Effects of mistletoe extract on XXXX thymocytes in vivo and on glucocorticoid-induced cell count reduction.

answer: @entity2


abstract: The operative records of 2816 @entity0 undergoing repair for @entity7 ( @entity7 ) from 1955 to 1985 were reviewed. Inflammatory aortic or @entity8 were present in 127 @entity0 (4.5%), 123 @entity0 and four @entity0 . Most @entity0 were heavy smokers (92.1%). Clinical evidence of peripheral @entity2 and @entity4 was found in 26.6% and 39.4%, respectively. Additional @entity3 occurred in half of the @entity0 ; @entity8 were the most common (55 @entity0 ), followed by @entity9 or thoracoabdominal (17 @entity0 ), femoral (16 @entity0 ), and popliteal @entity3 (10 @entity0 ). Ultrasound and computed tomography suggested the diagnosis in 13.5% and 50%, respectively; angiography was not helpful. Excretory urographic findings of medial ureteral displacement or obstruction suggested the diagnosis in 31.4%. The @entity3 was repaired in 126 @entity0 . Only one @entity0 experienced acute @entity10 , but eight @entity0 had chronic contained leakage. When compared with @entity0 who have ordinary @entity6 , @entity0 with inflammatory @entity3 are significantly more likely to have an elevated erythrocyte sedimentation rate (ESR, 73% vs. 33%, p less than 0.0001); @entity1 (20.5% vs. 10%, p less than 0.05); symptoms (66% vs. 20%, p less than 0.0001); and an increased operative mortality rate (7.9% vs. 2.4%, p less than 0.002). The triad of chronic @entity5 , @entity1 , and elevated ESR in a @entity0 with an @entity7 is highly suggestive of an inflammatory @entity3 and may be beneficial in the preoperative preparation of the @entity0 for @entity3 repair.

title: Inflammatory XXXX : a thirty-year review.

answer: @entity7


abstract: OBJECTIVE: Research has demonstrated that exposure to violence and adversity has negative effects on both mental health and biobehavioral outcomes, such as @entity1 . Research examining the relationship between past and recent violence exposure and mental health suggests that the effects of childhood adversity are especially pernicious, but to date, no studies have attempted to disentangle the direct, indirect and relative effects of past year versus childhood exposure to violence and adversity on sleep. The objective of the current study was to examine the direct effects of adverse childhood experiences (ACEs) and past year intimate partner violence (IPV) on different aspects of @entity1 in pregnant @entity0 . METHOD: A sample of high-risk pregnant @entity0 (n = 101) were interviewed. Mediation analysis with bias-corrected, bootstrapped confidence intervals was used to evaluate direct and indirect effects. RESULTS: Findings indicated that while ACEs had significant direct effects on mental health, past year IPV had stronger effects on @entity1 , latency, and efficiency. ACEs did, however, indirectly affect subjective @entity1 via past year @entity3 . CONCLUSION: These findings suggest that @entity1 may be a regulatory stress response that is most clearly linked to past year violence and @entity2 . That is, though long-term @entity1 may be evident following childhood adversity, it is likely that this relationship is better explained by the role of childhood adversity in predicting adulthood revictimization or due to long-term mental health difficulties associated with early @entity2 . (PsycINFO Database Record

title: Consequences of Violence Across the Lifespan: Mental Health and Sleep Quality in Pregnant XXXX .

answer: @entity0


abstract: INTRODUCTION: Extra @entity1 (EPN) alone represents a subgroup of @entity3 with better outcome than @entity0 with @entity1 ( @entity1 ). However, data on clinical significance of @entity7 is limited and significance of extent of EPN is not known. METHODS: 213 @entity0 (136 (63.8%) males; mean age: 39.8    13.2 years) with @entity2 ( @entity2 ) were prospectively enrolled and followed up till recovery or death. Contrast enhanced computed tomography (CECT) of each @entity0 was retrospectively evaluated for presence of @entity1 and EPN, @entity6 and @entity4 . EPN was termed extensive if it extended to paracolic gutters or pelvis. RESULTS: 21 (9.9%) @entity0 had @entity3 , 7 (3.3%) @entity0 had @entity1 alone, 48 (22.5%) @entity0 had EPN alone and 137 (64.3%) @entity0 had combined @entity1 _ EPN. @entity0 with EPN alone had significantly higher frequency of organ failure than @entity0 with @entity3 . Compared with @entity0 with EPN alone, the @entity0 with combined @entity1 had significantly higher frequency of @entity6 (88.2% versus 75%), @entity4 (41% versus 20.8%), and need for intervention (32.6% versus 14.6%). @entity0 with extensive EPN (n=57) had significantly higher frequency of @entity6 , @entity4 and @entity5 ( @entity5 ) than those with limited EPN. CONCLUSION: EPN alone should be considered as a separate category of @entity2 as it has less severe course than @entity1 but has more severe course than @entity3 . @entity0 with extensive EPN in spite of having increased frequency of @entity4 , @entity6 and @entity5 had similar outcome as compared to @entity0 with limited EPN.

title: Clinical Significance of Presence and Extent of Extra @entity1 in Acute XXXX .

answer: @entity3


abstract: BACKGROUND: Some @entity0 seem to show a particular propensity to experience systemic reactions (SR) when undergoing @entity2 . This study looked at their features. METHODS: 423 adults submitted to @entity2 ( @entity2 ) with 583 depot allergens extracts were studied. A "slow" build-up schedule was followed, and maintenance doses were given monthly. No mixtures of allergens were employed; multi-sensitized @entity0 were treated with two extracts at the same time. IgE to pollen allergen components were measured. @entity0 experiencing several SR and those showing repeated large local reactions preventing up dosing were analyzed. RESULT: Altogether, 14% of @entity0 experienced at least 2 SR to @entity2 and further 13% repeated local reactions. All SR involved the skin. Eight treatments were stopped. No reactor was using beta-blockers. SR were not associated with pollen season, use of freshly prepared vials, administration of 2 allergens, or extract producer, nor were preceded by large local reactions. Reactors were younger than tolerant subjects (p < 0.05), and females were less frequently fully tolerant than males (p < 0.001). The multiple regression analysis showed that both ragweed and grass @entity2 were significantly associated with adverse reactions (p < 0.001). Specific IgE to Amb a 1 or Phl p 1 did not differ statistically between reactors and tolerant subjects, whereas grass pollen-allergic reactors showed higher levels of IgE to Phl p 5. Intolerance did not depend on the number of primary sensitizations or on @entity1 to pollen pan-allergens. CONCLUSION: Young @entity0 or @entity0 hypersensitive to grass and ragweed pollen seem at higher risk for SR during @entity2 .

title: Detection of risk factors for systemic adverse reactions to XXXX with natural depot allergen extracts: a retrospective study.

answer: @entity2


abstract: A 48-year-old @entity0 admitted with progressive @entity11 had previously been diagnosed with @entity10 , @entity12 , and @entity3 , and had undergone mitral valve replacement with a Carpentier-Edwards pericardial bioprosthesis for @entity5 9 years before. She suffered a @entity6 5 years earlier, despite appropriate anticoagulant therapy. On admission, echocardiography showed severe @entity8 . Repeat mitral valve replacement was conducted using a Mosaic bioprosthesis. On postoperative day 2, when heparinization was commenced, she suddenly had an @entity4 fit. She also developed @entity1 , considered secondary to microthrombosis. @entity2 was administered and heparin replaced by @entity9 . @entity1 gradually disappeared, and she was discharged 3 months after surgery. The original bioprosthesis showed degenerative changes with significant @entity7 formation on cusps, thought to be mainly due to her hypercoagulable state. Considering the thrombophilic tendency in patients with @entity12 , strict management of anticoagulant therapy is required.

title: Secondary mitral valve replacement in XXXX and @entity3 .

answer: @entity12


abstract: BACKGROUND: Alterations of @entity5 ( @entity5 ) have been associated with the development of addiction to different drugs of abuse, including @entity4 ( @entity2 ). @entity2 exposure activates the @entity5 -signaling cascade in dorsal striatum, which in turn affects further @entity2 intake. Different @entity3 exposures have been widely demonstrated to modulate chromatin remodeling, affecting histone acetylation/deacetylation balance. Recently, class I histone deacetylases (HDACs) inhibition has been reported to modulate @entity5 mRNA expression and to attenuate morphological and behavioral phenomena related to @entity2 exposure. However, the role played by different HDAC isoforms in @entity2 -induced plasticity is still unclear. METHODS: We investigated the effects induced by acute @entity2 exposure on the protein levels of class I @entity6 -3 isoforms of @entity1 ( @entity1 ) and @entity5 heterozygous @entity0 ( @entity5 (+/-)), in nuclear and cytoplasmic extracts of specific brain regions associated with @entity2 addiction. RESULTS: Nuclear @entity6 -3 levels were markedly reduced after acute @entity2 treatment in the caudate putamen (CPu) of @entity1 @entity0 only. Furthermore, CPu basal levels of nuclear HDAC isoforms were significantly lower in @entity5 (+/-) @entity0 compared to @entity1 . With the exception of nuclear @entity7 , no significant changes were observed after acute @entity2 treatment in the prefrontal cortex (PFCx) of @entity5 (+/-) and @entity1 @entity0 . In this area, the nuclear HDAC basal levels were significantly different between the two experimental groups. CONCLUSIONS: These results provide details about @entity2 effects on class I HDAC isoforms and strongly support a correlation between @entity5 and class I HDACs, suggesting a possible influence of BNDF on these enzymes.

title: Effects of acute @entity4 exposure on class I HDACs family enzymes in XXXX and @entity5 (+/-) @entity0 .

answer: @entity1


abstract: UNASSIGNED: In a previous longitudinal diffusion tensor imaging (DTI) study, we observed cerebral white matter (WM) alterations (reduced fractional anisotropy (FA)) related to decreased cognitive performance 3-5  months after chemotherapy-treatment (t2) when compared to baseline (t1) (Deprez et al. in Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 30(3), 274-281. doi:10.1200/JCO.2011.36.8571, 2012). The current study investigates the evolution and the nature of these previously observed microstructural changes. Twenty-five young @entity1 with @entity0 who received chemotherapy treatment (C+), 14 who did not receive chemotherapy (C-) and 15 healthy controls (HC) previously studied, underwent reassessment 3-4  years after treatment (t3). We assessed (1) longitudinal changes of cognitive performance and FA and (2) cross-sectional group differences in myelin-water-imaging and multishell diffusion MRI metrics at t3. MRI metrics were assessed on a voxel-by-voxel basis and in regions-of-interest (ROI) in which previous @entity2 was detected. Longitudinal results: Mixed-effects modeling revealed significant group-time interactions for verbal memory and processing speed (p  <  0.05) reflecting regained performance in the C+ group at t3. Furthermore, in chemotherapy-treated @entity1 , FA returned to baseline levels at t3 in all ROIs (p  <  0.002), whereas no FA changes were seen in controls. Additionally, FA increase from t2 to t3 correlated with time since treatment in two of the four regions (r  =  0.40, p  <  0.05). Cross-sectional results: Advanced diffusion MRI and myelin-water imaging metrics in the ROIs did not differ between groups. Similarly, no whole-brain voxelwise differences were detected. Initial WM alterations and reduced cognitive performance following chemotherapy-treatment were found to recover in a group of young @entity0 survivors three to four years after treatment.

title: Recovery from chemotherapy-induced white matter changes in young XXXX survivors?

answer: @entity0


abstract: UNASSIGNED: Metastatic lesions in the large bowel are rare. A case of single symptomatic colonic @entity2 as first presentation of @entity1 ( @entity7 ) is described. A 62-year-old male was admitted with @entity5 and @entity3 . Colonoscopy revealed extrinsic compression at sigmoid colon, and microscopy suggested a secondary origin. Subsequent chest computed tomography confirmed a right perihilar mass invading posterior mediastinum, carina and esophagus, and also a second consolidation on right lower lobe and ipsilateral mediastinal and subcarinal lymph nodes. After pathologic evaluation of a transthoracic biopsy specimen, the diagnosis of pulmonary high-grade @entity7 , stage IV (T4, N3, M1b - 7th ed. @entity6 ), was established. Chemotherapy with carboplatin and paclitaxel was initiated, and disease progression occurred after two cycles with increasing @entity4 . Palliative surgery was rejected because of advanced stage, and the @entity0 was submitted to palliative pelvic radiotherapy. Second-line chemotherapy with gemcitabine was initiated, but clinical status worsened and the @entity0 died because of severe lung failure. Clinical, pathological and therapeutic aspects of this uncommon site of extrathoracic @entity2 are discussed, emphasizing the important contribution of special stains and immunohistochemistry to the diagnosis.

title: Single symptomatic colonic XXXX as first presentation of a @entity1 .

answer: @entity2


abstract: @entity6 ( @entity6 ) and insulin resistance (IR) are frequently associated with @entity1 and @entity3 . However, the exact roles of @entity6 and IR in the development of @entity1 are unclear. Mitogen-activated protein kinases (MAPK) are well-characterized intracellular mediators of cell proliferation. In this study, we examined the contribution of MAPK pathway in insulin-stimulated mitogenesis using primary vascular smooth muscle cells (VSMCs) isolated from aortas of normotensive @entity0 -Kyoto @entity0 (WKY) and spontaneous @entity1 @entity0 (SHR). VSMCs were grown to confluence in culture, serum starved, and examined for DNA synthesis (using @entity2 (TDR), immunoprecipitated MAPK activity, and MAPK phosphatase ( @entity10 ) induction). Basal rate of TDR incorporation into DNA was twofold higher in SHR compared with WKY (P < 0.005). Insulin caused a dose-dependent increase in TDR incorporation (150% over basal levels with 100 nM in 12 h). Stimulation was sustained for 24 h with a decline toward basal in 36 h. Pretreatment with @entity4 ( @entity9 antibody did not abolish mitogenesis mediated by 10-100 nM insulin, suggesting that insulin effect is mediated via its own receptors. Insulin had a small mitogenic effect in WKY (33% over basal). Insulin-stimulated mitogenesis was accompanied by a dose-dependent increase in MAPK activity in SHR, with a peak activation (>2-fold over basal) between 5 and 10 min with 100 nM insulin. Insulin had very small effects on MAPK activity in WKY. In contrast, serum-stimulated MAPK activation was comparable in WKY and SHR. Pretreatment with MEK inhibitor, @entity7 , completely blocked insulin's effect on MAPK activation and mitogenesis. Inhibition of @entity8 3-kinase with @entity5 also prevented insulin's effects on MAPK activation and mitogenesis. In WKY, insulin and @entity4 treatment resulted in a rapid induction of @entity10 , the dual-specificity MAPK phosphatase. In contrast, VSMCs from SHR were resistant to insulin with respect to MPK-1 expression. We conclude that insulin is mitogenic in SHR, and the effect appears to be mediated by sustained MAPK activation due to impaired insulin-mediated @entity10 mRNA expression, which may act as an inhibitory feedback loop in attenuating MAPK signaling.

title: Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in XXXX .

answer: @entity1


abstract: @entity4 (JCV) is a common @entity0 polyomavirus that infects 70-80% of the population worldwide. In immunosuppressed individuals, JCV infects oligodendrocytes and causes a fatal @entity1 known as @entity3 ( @entity3 ). The tropism of JCV is restricted to oligodendrocytes, astrocytes, and B lymphocytes. Several mechanisms may contribute to the restricted tropism of JCV, including the presence or absence of cell-type-specific transcription and replication factors and the presence or absence of cell-type-specific receptors. We have established a system to investigate cellular factors that influence viral tropism by selecting JCV-resistant cells from a susceptible glial cell line (SVG-A). SVG-A cells were subjected to several rounds of @entity2 using @entity4 ( @entity5 ). A population of resistant cells emerged (SVGR2) that were refractory to infection with the @entity6 strain of JCV, the hybrid virus @entity5 , as well as to the related polyomavirus SV40. SVGR2 cells were as susceptible as the SVG-A cells to infection with an unrelated amphotropic retrovirus. The stage at which these cells are resistant to infection was investigated and the block appears to be at early viral gene transcription. This system should ultimately allow us to identify glial specific factors that influence the tropism of JCV.

title: Derivation of a @entity4 -resistant XXXX glial cell line: implications for the identification of host cell factors that determine viral tropism.

answer: @entity0


abstract: BACKGROUND: Elevated fasting levels of branched chain @entity4 (BCAAs: @entity5 , @entity6 , @entity1 ) in venous blood are associated with a variety of @entity0 , including increased risk of @entity3 ( @entity3 ). Fasting @entity7 levels are influenced by non-dietary factors. However, it is unknown whether fasting BCAAs can be altered through manipulation of dietary intake alone. OBJECTIVE: To test whether a specific dietary intervention, using differences in @entity7 intake, alters fasting @entity7 levels independent of other factors. DESIGN: Five healthy male volunteers underwent 4 days of a low and 4 days of a high @entity7 content dietary intervention (ClinicalTrials.gov [NCT02110602]). All food and supplements were provided. Fasting BCAAs were measured from venous blood samples by mass spectrometry at baseline and after each intervention. RESULTS: Diets were isocaloric; contained equal percentages of calories from @entity2 , fats, and protein; and differed from each other in @entity7 content (1.5  0.1 vs. 14.0  0.6 g for @entity5 ; 4.5  0.9 g vs. 13.8  0.5 g for @entity6 ; 2.1  0.2 g vs. 27.1  1.0 g for @entity1 ; p<0.0001 for all). Fasting @entity5 was significantly lower (p=0.02) and fasting @entity6 and @entity1 were numerically lower following the low @entity7 content vs. the high @entity7 content diet levels. The inter-individual response to the dietary interventions was variable and not explained by adherence. CONCLUSION: Short-term dietary manipulation of @entity7 intake led to modest changes in fasting levels of BCAAs. The approach from our pilot study can be expanded to test the metabolic implications of dietary @entity7 manipulation.

title: A pilot, short-term dietary manipulation of branched chain XXXX has modest influence on fasting levels of branched chain @entity4 .

answer: @entity4


abstract: @entity1 ( @entity1 ) is a class of medications widely prescribed to @entity0 in the Western world. Evidence from animal models and in vitro studies suggests that @entity2 may protect against @entity6 and increase @entity5 synthesis, metabolism, and transport. Existing epidemiologic research indicates a possible reduced risk of @entity3 ( @entity3 ) associated with @entity1 use. The objective of this study was to evaluate @entity3 risk associated with specific @entity1 formulations. Neurologist-confirmed cases and age-matched controls were identified from Group Health Cooperative (GHC) of Washington State. Final analysis included 137 female cases and 227 controls. @entity1 use was ascertained from the GHC pharmacy database, further classified as conjugated @entity2 , esterified @entity2 , and @entity7 . Ever use of @entity1 formulation demonstrated a suggested elevated risk with esterified @entity2 use (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.0-9.8), and no risk associated with conjugated @entity2 use (OR, 0.6; 95% CI, 0.6-1.3). Restricting this analysis to prescriptions that included @entity7 further elevated the risk associated with esterified @entity2 use (OR, 6.9; 95% CI, 2.1-22.9); again, no risk was associated with conjugated @entity2 use (OR, 1.7; 95% CI, 0.6-5.0). The findings from this study suggest an increase in @entity3 risk associated with esterified @entity2 use combined with @entity7 , and no risk associated with conjugated @entity2 with @entity7 . These findings could have important implications for choice of @entity1 in clinical practice.    2014 International Parkinson and @entity4 Society.

title: Formulations of hormone therapy and risk of XXXX .

answer: @entity3


abstract: In 33 pediatric cases of @entity4 of the @entity9 (so-called @entity8 ), clinical features and CAG findings were studied with emphasis on their evolutionary aspects. The subjects were clinically classified as follows; 23 cases of pure transient @entity2 attacks ( @entity6 ), one presenting purely with @entity5 , one mixed @entity6 and @entity3 , two mixed @entity6 + @entity5 , and 6 mixed @entity3 and @entity5 . The core symptom of the @entity6 type is a recurrent unilateral or alternating unilateral paresis persisting for minutes or hours. Frequently hyperpnea provoked a @entity6 . Follow-up observation of the @entity6 type @entity0 for an average of 6 yrs 11 mos shows that about half the subjects became completely free of symptoms and the other half mostly improved considerably. In contrast, all @entity0 not presenting purely with @entity6 ("non- @entity6 " type) still had persistent @entity1 after a mean interval of 6 yrs 4 mos from the onset. The CAG findings in most cases belonged to stage III according to @entity7 's classification. Therefore the authors subdivided stage III into 3 substages, IIIa, IIIb and IIIc. The longer the duration of the disease up to the CAG examination, the more advanced was the CAG stage. Repeat CAGs examined after a mean interval of 2 yrs 11 mos demonstrated the same stage in 32%, and progress by one or two stages in 55% and 14% of the sides examined, respectively.

title: Clinical and cerebral angiographic evolutions of @entity4 of the XXXX ("moyamoya" disease) in @entity0 .

answer: @entity9


abstract: BACKGROUND: An elevated intramuscular pressure during a single forearm isometric muscle contraction may restrict muscle @entity1 . However, during repeated isometric exercise, it is unclear to what extent mechanical compression and muscle vasodilatation contribute to the magnitude and time course of beat-to-beat limb hemodynamics, due to alterations in leg vascular conductance (LVC). METHODS: In eight healthy male subjects, the time course of both beat-to-beat leg blood flow (LBF) and LVC in the femoral artery was determined between repeated 10-s isometric thigh muscle contractions and 10-s @entity0 (a duty cycle of 20  s) for steady-state 120  s at five target workloads (10, 30, 50, 70, and 90  % of maximum @entity2 (MVC)). The ratio of restricted LBF due to mechanical compression across workloads was determined by the formula (relaxation LBF   -   contraction LBF)/relaxation LBF (%). RESULTS: The exercise protocol was performed completely by all subjects ( <=50  % MVC), seven subjects ( <=70  % MVC), and two subjects ( <=90  % MVC). During a 10-s isometric muscle contraction, the time course in both beat-to-beat LBF and LVC displayed a fitting curve with an exponential increase (P   <   0.001, r (2)   >=    0.956) at each workload but no significant difference in mean LBF across workloads and pre-exercise. During a 10-s @entity0 , the time course in both beat-to-beat LBF and LVC increased as a function of workload, followed by a linear decline (P   <   0.001, r (2)   >=    0.889), that was workload-dependent, resulting in mean LBF increasing linearly across workloads (P   <   0.01, r (2)   =   0.984). The ratio of restricted LBF can be described as a single exponential decay with an increase in workload, which has inflection point distinctions between 30 and 50  % MVC. CONCLUSIONS: In a 20-s duty cycle of steady-state repeated @entity2 , the post-contraction @entity1 (magnitude of both LBF and LVC) during @entity0 was in proportion to the workload, which is in agreement with previous findings. Furthermore, time-dependent beat-to-beat muscle vasodilatation was seen, but not restricted, during @entity2 through all target workloads. Additionally, the relative contribution of mechanical obstruction and vasodilatation to the @entity1 observed in the repeated isometric exercise protocol was non-linear with regard to workload. In combination with repeated isometric exercise, the findings could potentially prove to be useful indicators of circulatory adjustment by mechanical compression for muscle-related disease.

title: Mechanical compression during repeated sustained XXXX and hyperemic recovery in healthy young males.

answer: @entity2


abstract: @entity2 frequently occurs after arterial interventions. The inducible form of @entity3 synthase ( @entity7 ) may both promote and inhibit @entity6 formation. This study investigated the role of @entity7 for @entity6 formation in a @entity0 model of @entity4 . The common carotid artery was ligated in anesthetized @entity0 . Homozygous @entity7 knockout @entity0 were compared with wild-type B6/129 @entity0 or wild-type @entity0 treated with the pharmacologic @entity7 inhibitor @entity5 given orally daily after ligation (n = 6-8 in each group). Vessels were harvested for quantification of lesion size 4 weeks later, or serially after ligation for tissue analysis. mRNA for @entity7 increased 1-4 days after ligation of the carotid artery. Cell proliferation could be visualized with an antibody against proliferating cell nuclear antigen. An intimal smooth muscle cell layer, confirmed by an alpha-actin antibody, was observed in the lumen 4 weeks after injury. Inhibition of @entity7 by either pharmacologic or genetic approaches tended to increase the area of intima formation (P = 0.13 or P < 0.05, respectively) and increased the intima/media ratio (P = 0.14 and P < 0.01, respectively). Inhibition of @entity7 by two different approaches increased @entity6 formation in a @entity0 model of @entity1 , indicating that the @entity7 expressed in the injured vessel wall is beneficial.

title: Deficiency of @entity3 synthase 2 results in increased @entity6 formation in a XXXX model of vascular injury.

answer: @entity0


abstract: BACKGROUND: Despite its increased incidence and status as the most prevalent @entity1 in Canada, there is a paucity of epidemiological data on @entity4 ( @entity4 ). OBJECTIVE: To assess @entity2 (KC) in Canada over 5 decades. METHODS: Articles published from 1960 to 2015 on @entity4 in Canada were identified through MEDLINE. Six articles met our search criteria. RESULTS: Overall, KC has increased. However, the rate of increase in the past decade has slowed down and decreased in younger age cohorts. @entity0 had higher incidences of KC. In both sexes, the @entity5 and @entity3 ratio was >= 2.5:1. Keratinocyte @entity2 were most commonly located on the head and neck, and increasing rates are occurring on the trunk. LIMITATIONS: The methods of registering @entity4 cases vary among different provinces. CONCLUSION: Keratinocyte @entity2 incidence is overall increasing; however, there may be evidence that the incidence is leveling off and decreasing in younger age cohorts.

title: Trends in @entity3 ( XXXX and @entity3 ) in Canada: A Descriptive Analysis of Available Data.

answer: @entity5


abstract: Three @entity1 were infested 4 times with 100 Amblyomma americanum tick pairs and kept indoors until the natural termination of the @entity0 . Characteristics of the tick populations that show efficiency of feeding, fertility, and offspring development, and ELISA antibodies to tick salivary gland extracts were studied at each @entity0 . On average, female ticks fed on tick-naive @entity1 detached at 12.1 +/- 0.2 (mean +/- standard error) days, weighed 492 +/- 16.8 mg, engorged 40.7 mg per day, and 35% survived to detachment during the first @entity0 . During the fourth @entity0 , they detached at 17.3 +/- 0.8 days, weighed 321 +/- 14.4 mg, engorged 18.8 mg per day on average, and 23% survived to detachment. On average, oviposition of female ticks fed on tick-naive @entity1 started at 11.8 +/- 0.6 days of detachment, the egg mass weighed 236 +/- 13.2 mg, 43% of the female weight turned into eggs, and 89% of the ticks that detached survived to oviposition during the first @entity0 . During the fourth @entity0 , oviposition started at 15.1 +/- 0.5 days, the eggs weighed 103 +/- 9.9 mg, 13% of the tick weight became eggs, and 67% of the ticks survived to oviposition. On average, eclosion started at 35.4 +/- 0.9 days of oviposition and 83% of the egg batches hatched in the first @entity0 . During the fourth @entity0 , eclosion started on day 34.9 +/- 0.7, and 47% of the egg batches hatched. Anti-tick resistance was expressed as an inhibition of feeding, fertility, and offspring development.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Manifestations of immunity in XXXX repeatedly infested with Amblyomma americanum ticks.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: The safety and efficacy of thrombolysis in @entity3 ( @entity3 ) are controversial. The aim of this meta-analysis was to pool all individual @entity0 data and provide a valid estimate of safety and outcome of thrombolysis in @entity3 . METHODS: We performed a systematic literature search on intravenous and intra-arterial thrombolysis in @entity3 . We calculated the rates of pooled symptomatic @entity2 and mortality and indirectly compared them with matched controls from the Safe Implementation of Thrombolysis in @entity1 Register. We applied multivariate regression models to identify predictors of excellent (modified Rankin Scale=0 to 1) and favorable (modified Rankin Scale=0 to 2) outcome. RESULTS: We obtained individual @entity0 data of 180 @entity0 from 14 retrospective series and 22 case reports. @entity0 were predominantly female (68%), with a mean  SD age of 46  11 years. Most @entity0 presented with severe @entity1 (median National Institutes of Health @entity1 Scale score=16). Treatment was intravenous thrombolysis in 67% and intra-arterial thrombolysis in 33%. Median follow-up was 3 months. The pooled symptomatic @entity2 rate was 3.1% (95% CI, 1.3 to 7.2). Overall mortality was 8.1% (95% CI, 4.9 to 13.2), and 41.0% (95% CI, 31.4 to 51.4) had an excellent outcome. @entity1 severity was a strong predictor of outcome. Overlapping confidence intervals of end points indicated no relevant differences with matched controls from the Safe Implementation of Thrombolysis in @entity1 Register. CONCLUSIONS: Safety and outcome of thrombolysis in @entity0 with @entity3 -related @entity1 appear similar to those for @entity1 from all causes. Based on our findings, thrombolysis should not be withheld in @entity0 with @entity3 .

title: Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: a meta-analysis of individual XXXX data.

answer: @entity0


abstract: Neutrophils, monocytes and dendritic cells are effectors of innate immunity and essential coactivators in the acquired immune response. Understanding the biochemical basis of their mature cell functions, their differentiation from hematopoietic progenitors, and the mechanisms by which @entity5 oncogenes block their differentiation programs, continue to be areas of active research. Four major problems limit progress in these fields. First, the biochemical analysis of mature cells is limited by the time and cost of purifying neutrophils, monocytes, or dendritic cells from wild-type and genetically modified @entity0 strains. Second, while immortal myeloid cell lines are used to understand the transcriptional basis of normal terminal differentiation following their treatment with differentiationpromoting agents (e.g. @entity7 , @entity2 , RA, @entity3 ), these cells contain stable defects responsible for their immortalization, and the degree to which they model normal differentiation is often incomplete. Third, these same inducible cell lines are used as model systems to determine how myeloid oncoproteins prevent differentiation; however, oncoproteins that block differentiation of marrow progenitors cultured in @entity4 or @entity6 but permit their differentiation in response to @entity7 or RA, do not score effectively in these assays (e.g. @entity8 , @entity9 -Enl). Fourth, there is no reproducible method to derive myeloid progenitor lines that execute predictable terminal differentiation to neutrophils, monocytes, or dendritic cells. Developing this type of system is needed to evaluate how myeloid gene inactivation by knockout technologies alters lineage-specific differentiation and mature cell function. Conditional myeloid oncoproteins provide a tool to solve these research problems by providing a predictable and inexpensive means of expanding, in culture, @entity4 - or @entity6 -dependent myeloid progenitors from any genotype, and by permitting their synchronous differentiation to neutrophils, monocytes, or dendritic cells under defined culture conditions following inactivation of the conditional oncoprotein. This system of conditionally immortalizing normal bone marrow precursors provides the large numbers of normal cells required for analysis of cell biology and protein biochemistry, and further provides a model system in which to study the genetic mechanisms controlling terminal differentiation and how specific oncoproteins expressed in the cell lines prevent this differentiation program. The ability to derive conditionally-immortalized progenitor lines from knock-out @entity0 provides cell lines for the reconstitution of knockout gene function and subsequent dissection of knockout protein function by mutational analysis. Finally, conditional myeloid cell lines can be established from both ES cells and from d10 fetal liver cells, allowing for the analysis of embryonic lethal mutants on both the maturation and terminal differentiation of mature myeloid cells. In this review,we summarize the importance and limitations of current approaches in myeloid cell research, and how @entity1 -regulated conditional oncoproteins help to solve these problems.

title: @entity1 -regulated conditional oncoproteins: tools to address open questions in normal myeloid cell function, normal myeloid differentiation, and the genetic basis of differentiation arrest in XXXX .

answer: @entity5


abstract: Rumenocentesis is commonly used to collect rumen fluid to screen for @entity2 . This study was designed to investigate whether rumenocentesis induced @entity0 and stress and, if so, whether local anaesthesia could limit this. Twenty-four dairy @entity1 were assigned to one of three treatments: (1) rumenocentesis with local anaesthesia (AR); (2) rumenocentesis without local anaesthesia (R); and (3) local anaesthesia only (A). Treatments were performed in a restraining cage. The @entity1 were placed in the cage on three consecutive days and anaesthesia and/or rumenocentesis was performed on the second day. Blood samples for @entity3 determination and heart rate were recorded from 0.25 h before treatment until 4h after. Behaviour was noted while the @entity1 were caged. Feed intake and milk production were measured the week before treatment, on the day of treatment, and the day after. With all three treatments, @entity3 concentrations and heart rate were increased while @entity1 were in the cage. @entity3 , cardiac and behavioural responses were not significantly higher in the R and AR treatments than the A group. @entity3 concentrations and heart rate did not change between days. Feed intake and milk production were unaffected by the treatments. It was concluded that rumenocentesis does not appear more stressful than local anaesthesia or handling.

title: An assessment of the impact of rumenocentesis on XXXX and stress in @entity1 and the effect of local anaesthesia.

answer: @entity0


abstract: OBJECTIVE: @entity7 , an orally active third-generation selective @entity4 -receptor modulator (SERM), opposes the action of @entity4 on the breast and endometrium but exerts an @entity4 -agonist effect on bone and the lipid profile. Since this is an appealing combination for hormonal therapy of @entity4 -related @entity2 , we initiated testing the potential of @entity7 in @entity1 with @entity6 . METHODS: Two phase I studies were conducted to evaluate the safety and pharmacokinetics of single and multiple doses of @entity7 . In addition, two multi-institutional phase II trials have been completed on 100 @entity1 with metastatic or recurrent @entity6 . RESULTS: No serious adverse events were observed in the single-dose phase I study, the principal side effect being hot flashes in 5/15 healthy volunteers. In the second phase I study, conducted in 32 @entity1 with metastatic @entity0 , one @entity1 had a serious, possibly drug-related adverse reaction ( @entity5 ). The two multi-institutional trials demonstrated significant activity at 20 mg/day in @entity1 with metastatic or recurrent @entity6 . Observed clinical response rates were 25 and 31%, with a median response duration of 19.3 and 13.9 months, respectively. Progression of the disease was stabilized in a substantial number of @entity1 . @entity3 was mild, except for two cases of @entity5 that might have been drug related. CONCLUSIONS: Further investigation is warranted to verify these preliminary response rates and the clinical significance of the stable disease cases, to compare clinical outcomes with those in progestin-treated @entity1 , and to elucidate the mechanisms of SERM action in this disease.

title: @entity7 as therapy for XXXX .

answer: @entity6


abstract: The large majority of childhood B-precursor cell @entity2 cases present @entity4 and TCRdelta gene rearrangements. These rearrangements have been widely used as specific markers for monitoring @entity1 . However, their prognostic value still remains unclear. In order to determine whether @entity4 and TCRdelta gene rearrangements have any influence on relapse and @entity3 ( @entity3 ), we analysed the clinical impact of these genetic characteristics in 51 B-precursor @entity2 @entity0 . 46/51 @entity0 (90.2%) showed @entity4 gene rearrangements by Southern blot and/or polymerase chain reaction (PCR) analysis. No statistically significant associations were found between @entity4 gene rearrangement pattern and age, sex, WBC count, immunophenotype, risk factor, relapse or @entity3 . 27/41 @entity0 (66%) showed Vdelta2Ddelta3 recombination by Southern blot and/or PCR analysis. At a median follow-up of 53 months the estimated 5-year @entity3 probability was 78 +/- 3% for the whole group. The @entity3 probability among @entity0 with a Vdelta2Ddelta3 recombination pattern in the TCRdelta locus was 90 +/- 3%, whereas for @entity0 without Vdelta2Ddelta3 recombination was 39 +/- 13% (P < 0.005). @entity4 rearrangement patterns do not appear to influence relapse or @entity3 probability. However, TCRdelta gene rearrangement patterns have a relevant impact on the relapse rate and the @entity3 probability. @entity0 with Vdelta2Ddelta3 recombination have better clinical outcome than @entity0 without this recombination, independent of any other prognostic factors.

title: Clinical relevance of T-cell receptor delta gene rearrangements in childhood B-precursor cell XXXX .

answer: @entity2


abstract: A diagnosis of @entity12 with @entity12 (GPA) can be challenging given various clinical manifestations. We report an incident case of GPA presenting with chronic @entity8 and mimicking an early @entity11 without renal involvement. A 51 year-old @entity0 with @entity7 presented with subacute @entity10 , @entity6 and @entity3 . Physical examination revealed a right nasal mass without discharge or @entity5 . @entity10 sounds and dullness to percussion were noted at the left lung base. Laboratory findings were significant for @entity4 but normal renal function. The chest CT demonstrated dense consolidation with hypo-enhancement of the lingula. The sinus CT revealed an enhancing mass in the right nasal cavity and anterior ethmoid sinuses with associated bony destruction. @entity0 did not improve with empiric antibiotics for @entity11 . Aspiration of the lingular fluid showed purulent material, however, microbes did not grow in culture. A positive @entity13 screen was confirmed. A right nasal biopsy was performed which revealed @entity1 with focal @entity2 and @entity9 . The final diagnosis was GPA. Given various clinical manifestations, the diagnosis of GPA can be difficult to distinguish from infectious etiologies. This can delay the treatment, which may be life-saving and organ sparing. We emphasize that an initial screening ANCA serology test is recommended in @entity0 with suggestive clinical findings of GPA. Biopsy of an affected organ is paramount for the definitive diagnosis.

title: XXXX with @entity12 : A Case of Nasal Mass, Necrotic Lung, and Normal Kidneys.

answer: @entity12


abstract: We report a case of @entity2 presenting @entity5 due to overeating of seaweed that was noticed as a result of a discrepancy between glycated albumin (GA) and glycated hemoglobin (GHb). A 71-year-old @entity0 was undergoing managed treatment with oral medicines and insulin for @entity2 with no sign of @entity4 . Her thyroid function was euthyroid without aid of thyroid hormone. All of the @entity0 's thyroid autoantibodies were negative. Fifteen weeks prior to indications of @entity5 , she had started to consume large amounts (100-200 g dry weight equivalent) of cooked "wakame" seaweed every morning. Just before admission to our hospital, her GA was 26.9%, while GHb and fasting plasma @entity3 remained within normal ranges (less than 5.6%, and 106 mg, respectively). This discrepancy between GA and GHb drew our attention to the development of complications. Naive interview of the @entity0 led us to believe a @entity4 existed, though without any related complaints or findings, such as non-pitting @entity1 , cold intolerance, or easy fatiguing. Seaweed consumption was stopped and periodic observation of thyroid function started. As thyroid hormone levels moved into normal range, GA and GHb returned to their normal relative ratio after 3 months. Thus, measurement of the relative ratio of GA and GHb may be useful for glycemic monitoring, with the potential as a readily available glycemic control marker for @entity0 with changeable complications.

title: A case of @entity2 developing XXXX discovered as a result of a discrepancy between glycated hemoglobin and glycated albumin values.

answer: @entity5


abstract: OBJECTIVES: To investigate the characteristics of young @entity9 ( @entity9 ) @entity0 and determine outcome in terms of mortality and risk factors for suicide. METHOD: Information was collected on consecutive @entity9 @entity0 aged 15 through 24 years presenting to a general hospital during a 20-year period (1978-1997). Deaths to the end of 2000 were identified through national mortality registers. RESULTS: Of 5459 @entity0 in the cohort, 62.9% were female and 37.1% male. @entity5 (90.5% of @entity9 episodes) most frequently involved @entity4 (44.0%). @entity4 and antidepressant @entity5 increased during the study period, whereas @entity5 of minor tranquilizers decreased. More than one third of @entity0 (36.1%) drank @entity2 immediately before @entity9 . The most frequent problems faced by @entity0 involved family members, partners, employment/ studies, and friends. One quarter of @entity0 (26.3%) had a history of prior @entity9 . Of 4843 @entity0 followed up, 141 (2.9%) died (90 males [5.0%] and 51 females [1.7%]), the risk of death being 4 times greater than expected. More than half (81; 57.4%) of the @entity3 were from probable suicide, which was approximately 10 times more frequent than expected. Risk factors for suicide included male gender, previous @entity9 , prior @entity1 history (females), and high suicide intent. There were also more @entity3 than expected from @entity7 , @entity6 , and accidents that did not involve @entity8 . CONCLUSIONS: The range of characteristics of young @entity9 @entity0 indicates the multifactional nature of aftercare required following @entity9 . The very high risk of suicide after @entity9 in young @entity0 highlights the need for preventive initiatives in this population.

title: Deliberate self-harm in young XXXX : characteristics and subsequent mortality in a 20-year cohort of @entity0 presenting to hospital.

answer: @entity0


abstract: OBJECTIVE: This study was performed to determine whether MR imaging can be used to reliably measure global myocardial blood flow and coronary flow reserve in @entity0 with @entity2 as compared with such measurements obtained by positron emission tomography (PET). SUBJECTS AND METHODS: We measured myocardial blood flow first at baseline and then after @entity4 -induced @entity1 in 20 @entity0 with @entity2 . Myocardial blood flow as revealed by MR imaging was calculated by dividing coronary sinus flow by the left ventricular mass. Coronary flow reserve was calculated by dividing the rate of hyperemic flow by the rate of baseline flow. RESULTS: Using MR imaging, myocardial blood flow at baseline was 0.73 +/- 0.23 mL x @entity3 ) x g(-1), and at @entity1 the blood flow was 1.43 +/- 0.37 mL x @entity3 ) x g(-1), yielding an average coronary flow reserve of 1.99 +/- 0.47. Using PET, myocardial blood flow was 0.89 +/- 0.21 mL x @entity3 ) x g(-1) at baseline and 1.56 +/- 0.42 mL x @entity3 ) x g(-1) at @entity1 , yielding an average coronary flow reserve of 1.77 +/- 0.36. The correlation of myocardial blood flow and coronary flow reserve measurements for these two methods was an r of 0.80 (p < 0.01) and an r of 0.50 (p < 0.05), respectively. CONCLUSION: This study shows that myocardial blood flow measurements obtained using MR imaging have a good correlation with corresponding PET measurements. Coronary flow reserve measurements obtained using MR imaging had only moderate correlation with PET-obtained measurements. Our results suggest that MR imaging flow quantification could potentially be used for measuring global myocardial blood flow in @entity0 in whom interventional treatment for @entity2 is being evaluated.

title: Assessing coronary sinus blood flow in XXXX with @entity2 : a comparison of phase-contrast MR imaging with positron emission tomography.

answer: @entity0


abstract: UNASSIGNED: Garlic contains numerous compounds that have the potential to influence immunity. Immune cells, especially innate immune cells, are responsible for the @entity1 necessary to kill pathogens. Two innate lymphocytes, y  -T and natural killer (NK) cells, appear to be susceptible to diet modification. The purpose of this review was to summarize the influence of aged garlic extract (AGE) on the immune system. The author's laboratory is interested in AGE's effects on cell proliferation and activation and @entity1 and to learn whether those changes might affect the occurrence and severity of colds and @entity2 . Healthy @entity0 @entity0 (n = 120), between 21 and 50 y of age, were recruited for a randomized, double-blind, placebo-controlled parallel-intervention study to consume 2.56 g AGE/d or placebo supplements for 90 d during the cold and @entity2 season. Peripheral blood mononuclear cells were isolated before and after consumption, and y  -T and NK cell function was assessed by flow cytometry. The effect on cold and @entity3 was determined by using daily diary records of self-reported illnesses. After 45 d of AGE consumption, y  -T and NK cells proliferated better and were more activated than cells from the placebo group. After 90 d, although the number of illnesses was not significantly different, the AGE group showed reduced cold and @entity2 severity, with a reduction in the number of symptoms, the number of days @entity0 functioned suboptimally, and the number of work/school days missed. These results suggest that AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and @entity2 reported. The results also suggest that the immune system functions well with AGE supplementation, perhaps with less accompanying @entity1 . This trial was registered at clinicaltrials.gov as NCT01390116.

title: Aged Garlic Extract Modifies XXXX Immunity.

answer: @entity0


abstract: BACKGROUND: The therapeutic outcome and @entity2 of 3-D conformal photon external beam therapy of @entity3 is well documented in the literature. Progress is still in work for optimization of treatment strategies by risk-adapted dose escalation studies to improve @entity1 control without increase of radiation side effects. @entity0 AND METHODS: We present our experience of 291 @entity0 treated between January 1994 and August 1997 with a 3-D planned four-field box technique and a central dose of 66 Gy. Biochemical response of @entity0 with radiotherapy alone (group 1, n = 72 pts.) has been analyzed in detail. Acute radiation side effects are given for all @entity0 (n = 291), late radiation side effects are given for @entity0 treated between Jan 1994 and Jan 1996 with a median follow-up of 22 months (n = 115 pts.). RESULTS: We have observed a biochemical response (nadir PSA < 1 after 12 months, < 2 after 6 months) for @entity0 treated with radiotherapy alone without hormone manipulation in 67%. Incidence of late rectal and bladder morbidity (grade 2 and 3) was 9.4% and 4%, respectively. CONCLUSION: Compared to other reports our results indicate a high rate of @entity1 control (early biochemical response) and a low rate of late morbidity. Nevertheless, we will start a risk-adapted dose escalation study up to 74 Gy for unfavorable subgroups (G2-3, Gleason Score > 7, PSA > 10) to improve treatment outcome.

title: Three dimensional conformal photon radiotherapy at a moderate dose level of 66 Gy for XXXX : early results.

answer: @entity3


abstract: PURPOSE: In @entity2 -in contrast to various other cancers-the impact of T-lymphocytes on clinical outcome is not clear. We investigated the clinical relevance and regulation of T-cell infiltration in @entity2 . EXPERIMENTAL DESIGN: T-cell subpopulations from entire sections of 93 WHO  II-IV @entity2 were computationally identified using markers CD3, @entity4 , and @entity3 ; survival analysis was then done on primary @entity5 (pGBM). Endothelial cells expressing cellular adhesion molecules (CAM) were similarly computationally quantified from the same @entity2 tissues. Influence of prominent cytokines (as measured by ELISA from 53 WHO  II-IV @entity2 lysates) on CAM-expression in @entity2 -isolated endothelial cells was determined using flow cytometry. The functional relevance of the cytokine-mediated CAM regulation was tested in a transmigration assay using @entity2 -derived endothelial cells and autologous T-cells. RESULTS: Infiltration of all T-cell subsets increased in high-grade @entity1 . Most strikingly, within pGBM, elevated numbers of intratumoral effector T cells (T(eff), cytotoxic and helper) significantly correlated with a better survival; regulatory T cells were infrequently present and not associated with @entity2 @entity0 outcome. Interestingly, increased infiltration of T(eff) cells was related to the expression of @entity6 on the vessel surface. Transmigration of autologous T cells in vitro was markedly reduced in the presence of CAM-blocking antibodies. We found that @entity7 molecules impeded transmigration and downregulated CAM-expression on @entity2 -isolated endothelial cells; blocking @entity7 receptor signaling increased transmigration. CONCLUSIONS: This study provides comprehensive and novel insights into occurrence and regulation of T-cell infiltration in @entity2 . Specifically, targeting @entity7 and @entity8 might improve intratumoral T-cell infiltration and thus enhance effectiveness of immunotherapeutic approaches.

title: Effector T-cell infiltration positively impacts survival of XXXX @entity0 and is impaired by tumor-derived @entity7 .

answer: @entity5


abstract: In this report, we describe a female @entity0 with trisomy 4p, a rare @entity1 , with unusual @entity2 semiology. The @entity0 is one of the oldest reported survivors with this condition. This semiology was noted while she was being monitored by inpatient video telemetry. We observed a series of @entity3 jerks, followed by @entity4 , and finally an atonic head drop. Corresponding ictal EEG showed semi-rhythmic high-amplitude slow waves with spikes superimposed over the frontotemporal areas. This semiology was confirmed as habitual by her parents. Subsequent @entity4 had no EEG correlate, and the head drop was again associated with semi-rhythmic high-amplitude slow waves and superimposed spikes, more prominent over the right hemisphere. In addition, we review the several cases in which @entity4 have been associated with @entity2 and how this may relate to the neural pathways involved in the pathophysiology of @entity4 . We believe the @entity4 followed by atonia to be a @entity2 semiology that has not previously been documented. [Published with video sequence].

title: Diaphragm XXXX followed by generalised atonia in a @entity0 with trisomy 4p: unusual semiology in an unusual condition.

answer: @entity3


abstract: OBJECTIVE: High-fidelity @entity0 simulation (HFPS) has been used in medical education to bridge gaps in medical knowledge and clinical skills. Few studies have analyzed the impact of HFPS in subspecialty rotations for pediatric residents. We hypothesized that pediatric residents exposed to HFPS with a structured content curriculum would perform better on a case quiz than residents without exposure to HFPS. DESIGN: Prospective randomized controlled SETTING: Tertiary-care free standing @entity0 's hospital INTERVENTIONS: During a @entity1 , senior pediatric residents completed an online pediatric cardiology curriculum and a cardiology quiz. After randomization into two groups, the study group participated in a fully debriefed HFPS session. The control group had no HFPS. OUTCOME MEASURE: Both groups completed a case quiz. Confidence surveys pre- and postsimulation were completed. RESULTS: From October 2010 through March 2013, 55 residents who rotated through the pediatric @entity1 were used in the final analysis (30 control, 25 in the study group). There was no significant difference between groups on the initial cardiology quiz. The study group scored higher on the case quiz compared with the control group (P = .024). Based on pre- and postsimulation questionnaires, residents' confidence in approaching a pediatric cardiology @entity0 improved from an average Likert score of 5.1 to 7.5 (on scale of 0-10) (P < .001). CONCLUSIONS: Incorporation of HFPS into a preexisting pediatric @entity1 was feasible and well received. Our study suggests that simulation promotes increased confidence and may modestly improve clinical reasoning compared to traditional educational techniques. Targeted simulation sessions may readily be incorporated into pediatric subspecialty rotations.

title: Embedding XXXX Simulation in a Pediatric Cardiology Rotation: A Unique Opportunity for Improving Resident Education.

answer: @entity0


abstract: Background. It is generally accepted that poor glycemic control, arterial @entity3 and/or @entity5 , and the associated oxidative stress may contribute to the development of macro- and microvascular complications in @entity8 ( @entity8 ). Such metabolic damage signals may activate inflammasome and trigger chronic @entity2 . We investigated common polymorphisms in inflammasome coding genes and the risk for macro- and microvascular complications in @entity8 . Methods. In total 181 clinically well-characterised @entity8 @entity0 were genotyped for @entity10 @entity13 and @entity11 @entity12 . Risk for @entity1 complications was assessed using logistic regression. Results. @entity0 with median duration of @entity8 11 (6-17) years had relatively well controlled blood @entity6 and lipid levels and blood pressure on the prescribed treatment regimen. Duration of @entity8 and plasma @entity4 levels were the most important clinical risk factors for macrovascular complications (P = 0.007 and P = 0.031). @entity10 @entity13 was associated with increased risk for macrovascular complications (P = 0.004), with @entity7 in particular (P = 0.052). No association was observed between @entity11 polymorphism and any of @entity8 complications. Conclusions. Our preliminary data suggest the role of @entity10 polymorphism in @entity9 , especially in @entity7 .

title: XXXX Inflammasome Polymorphism and Macrovascular Complications in Type 2 @entity1 @entity0 .

answer: @entity10


abstract: BACKGROUND: Exposure to high levels of cat allergen might prevent sensitization. OBJECTIVE: We sought to measure the incidence of allergic sensitization among schoolchildren living in a dust mite- and cockroach-free environment and the associated risk factors. METHODS: In 1996, a longitudinal cohort was established in northern Sweden, including 2454 @entity0 aged 7 to 8 years. @entity0 were skin tested, and the testing was repeated 4 years later. Questionnaires were completed yearly. Participation was 88% both in 1996 and 2000. RESULTS: The prevalence of positive skin test results increased from 20.6% at age 7 and 8 years to 30.4% at age 11 and 12 years, a cumulative incidence of 13.8%, and was significantly higher among @entity0 . The incidence was highest for cat (6.0%), timothy grass (5.9%), @entity1 (4.9%), and birch (3.6%). A family history of @entity2 was the major risk factor for both a positive skin test response at age 7 and 8 years (odds ratio [OR], 1.69; 95% CI, 1.36-2.10) and for development of a positive skin test response over the next 4 years (OR, 1.67; 95% CI, 1.23-2.28). A significant inverse association between cat and @entity1 ownership and the prevalence of type 1 @entity2 was found, particularly for those @entity0 who had lived with a cat both before age 7 and 8 years and during the next 4 years (OR, 0.44; 95% CI, 0.31-0.61). A similar pattern, although not significant, was found for incident cases. CONCLUSION: The high incidence of type 1 @entity2 at this age was similar to reports from communities with mite and cockroach allergen. Despite cat and @entity1 being the most common allergens of sensitization, keeping these animals at home was not associated with an increased risk for sensitization.

title: Four-year incidence of allergic sensitization among schoolchildren in a community where XXXX to cat and @entity1 dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group.

answer: @entity2


abstract: OBJECTIVE: @entity3 ( @entity3 ) are common in the female population and, over a lifetime, about half of @entity0 have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent @entity4 : intravesical instillation of hyaluronic acid (HA) plus @entity5 (CS), and antibiotic prophylaxis with @entity2 plus @entity1 . MATERIALS AND METHODS: This was a retrospective review of two different cohorts of @entity0 affected by recurrent @entity4 . Cases (experimental group) were @entity0 who received intravesical instillations of a sterile solution of high concentration of HA  +  CS in 50  mL water with @entity6 every week during the 1(st) month and then once monthly for 4 months. The control group included @entity0 who received traditional therapy for recurrent @entity4 based on daily antibiotic prophylaxis using @entity2 200  mg plus @entity1 40  mg for 6 weeks. RESULTS: Ninety-eight and 76 @entity0 were treated with experimental and control treatments, respectively. At 12 months after treatment, 69 and 109 @entity3 were detected in the experimental and control groups, respectively. The proportion of @entity0 free from @entity3 was significantly higher in the experimental than in the control group (36.7% vs. 21.0%; p  =  0.03). Experimental treatment was well tolerated and none of the @entity0 stopped it. CONCLUSION: The intravesical instillation of HA  +  CS is more effective than long-term antibiotic prophylaxis for preventing recurrent @entity4 .

title: Is intravesical instillation of hyaluronic acid and @entity5 useful in preventing recurrent XXXX ? A multicenter case control analysis.

answer: @entity4


abstract: A 56 year old @entity0 presented with increasing @entity4 . He suffered from @entity3 with @entity3 . iliaca communis. Angiography revealed partial @entity6 occlusion of the superior mesenteric artery. Urokinase (UK) at a dose of 150 IU/kg X minutes and heparin (1,000 U/h) was infused through the 7F angiographic catheter for 180 minutes. After 70 min of treatment, angiography showed improvement, and after 120 min the thrombus was nearly completely lysed. A stenosis of approximately 50% was still present after 180 min. Two hours after treatment the @entity0 was @entity1 free without analgesics. Laboratory studies showed systemic fibrinogenolysis, but fibrinogen was still within the upper normal range. Only slight systemic fibrinolytic activity (less than 5 IU UK/ml) could be determined. However, alpha 2-antiplasmin was depleted. The catheter was drawn 15 h after thrombolysis without @entity5 . While under concurrent heparin and phenprocoumon therapy, the @entity0 developed an @entity2 as a result of i.m. injections prior to this treatment. A repeat angiography approximately one month after thrombolysis revealed further improvement and patency. The @entity0 is well and free of @entity7 and under oral anticoagulant therapy.

title: [Successful treatment of superior mesenteric artery XXXX with local high-dose urokinase therapy].

answer: @entity6


abstract: There is scant knowledge on the changes in renal histological findings in type 1 @entity1 @entity0 those initially had @entity11 and @entity6 and later had complete remission of @entity12 by @entity3 ( @entity3 ). A 44-year-old Japanese type 1 @entity1 @entity0 (duration of @entity1 : 17 years) with massive @entity8 (2.9 g/day) and @entity6 ( @entity9 clearance rate (Ccr): 86 mL/min) was admitted. @entity5 @entity3 was started with intensive insulin treatment, a low protein and low salt diet, @entity10 inhibitor and a diuretic. Her levels of HbA1c decreased to less than 7% within 4 months, and her high blood pressure gradually decreased and remained around mean 116/68 mmHg. Her Ccr level gradually improved and reached 108 mL/min after 78 months. Her first renal biopsy performed before @entity3 demonstrated diffuse and/or global accumulation of periodic acid-Schiff staining-positive mesangial matrix with @entity13 /glomerulus ratio and tubulo-interstitial @entity4 . Her second renal biopsy performed 5 years after @entity3 demonstrated decreased mesangial matrix/glomerulus ratio (42.0+/-4.0% to 29.2+/-1.9% [mean+/-S.D.], p<0.001) and increased her number of glomerular capillaries lumen per glomerulus (47+/-11 to 77+/-12, p<0.006). The number of @entity2 ( @entity2 )-expressing cells in the glomerular capillary significantly increased. Increased tubulo-interstitial @entity4 and the thickness of @entity7 ( @entity7 ) seen in the first biopsy specimen had decreased in the specimen taken at the second biopsy. Our case provides evidence that glomerular morphological improvements including decreased mesangial deposit and @entity2 -related vasculogenesis in response to @entity3 goes along with functional normalization of @entity12 , which could not be attained in type 1 @entity1 @entity0 that underwent pancreas transplantation.

title: Complete remission of @entity12 in a type 1 @entity1 @entity0 with near- @entity11 range XXXX and @entity6 .

answer: @entity8


abstract: OBJECTIVE: Repeated percutaneous interventions on failing @entity1 ( @entity1 ) and @entity2 ( @entity2 ) for hemodialysis are common, but the outcomes are largely unknown. We sought to determine the results of the second percutaneous intervention on failing @entity2 and @entity1 and to identify factors associated with loss of patency. METHODS: For the purpose of this study, the second percutaneous intervention was identified as the index procedure. We reviewed the second percutaneous interventions on failing @entity1 and @entity2 at a single institution between 2007 and 2013. @entity0 comorbidities, graft or fistula configuration, lesion characteristics, and procedural characteristics of the intervention performed were analyzed with respect to technical success, primary patency, primary assisted patency, and secondary patency. Patency was defined per Society for Vascular Surgery recommended reporting standards and was determined from the time of the index procedure. Cox proportional hazards multivariable modeling was performed to identify independent determinants of loss of patency. RESULTS: Among 91 @entity0 , 96 second-time percutaneous interventions were performed on 52 @entity1 and 44 @entity2 . @entity0 included 56% @entity0 and 44% @entity0 with a mean age of 64     17  years. The lesions intervened on were primarily located along the accessed portion of the outflow in @entity1 and within the length of the graft and at the venous anastomosis in @entity2 . Transluminal angioplasty alone was performed in 82 procedures (85%), and uncovered or covered stents were placed in 15 procedures (16%). Pharmacomechanical thrombectomy was performed in 32 @entity0 (34%) and was more commonly performed in @entity2 compared with @entity1 (53% vs 17%; P  = .0002). Technical success was achieved in 90 procedures (97%; n  = 92). One-year primary patency, assisted primary patency, and secondary patency rates were 35%, 86%, and 86%, respectively. One-year primary patency did not differ between @entity1 and @entity2 , but secondary patency was lower for AVG in comparison to AVF (P  = .04). On multivariable analysis, only the need for pharmacomechanical thrombectomy significantly predicted failure of primary patency (hazard ratio, 2.6; 95% confidence interval, 1.6-4.3). The presence of an AVG rather than an AVF independently predicted failure of secondary patency (hazard ratio, 2.9; 95% confidence interval, 1.0-8.2). CONCLUSIONS: The second percutaneous interventions on @entity1 and @entity2 are associated with excellent technical success but poor primary patency. The need for pharmacomechanical thrombectomy predicts the need for additional percutaneous intervention to maintain patency. With additional interventions, acceptable secondary patency out to 5  years can be achieved, although @entity2 have inferior secondary patency to @entity1 . To develop optimal practice management algorithms, the effectiveness of repeated percutaneous interventions for failing @entity2 and @entity1 vs creation of a new access should be further investigated.

title: Results of repeated percutaneous interventions on failing XXXX and grafts and factors affecting outcomes.

answer: @entity1


abstract: OBJECTIVE: This retrospective study comes forward to study our management of left @entity4 by evaluating the mortality and the morbidity. @entity0 AND METHODS: From 1984 to 2001, 21 @entity0 with left @entity4 were treated in emergency. They were 12 males and 9 females with a mean age of 40.6 years. All the @entity0 had complete clinical and radiological @entity4 . The pre-operative neoplastic origin of the obstruction was unknown in 20 cases. Six @entity0 had hepatic metastases and 6 ovarian metastases. Six @entity0 were classified as Asa II and 6 other Asa III. Nineteen @entity0 (90.5%) underwent Hartmann's operation. The 2 remaining @entity0 had immediate @entity2 after colectomy, with diverting ileostomy. These procedures were associated with hepatectomy in 5 cases and annexectomy in 6 cases. Intestinal continuity restoration was possible in 13 cases between 6 months and 1 year. RESULTS: Operative mortality was 9.5% (2 cases). @entity1 were due to evisceration caused by parietal suppuration in one case and @entity5 in the other case. There was no anastomotic @entity3 . Mean hospital stay was 14 days (12-21). Survival was 84% at one year and 0% at 5 years. CONCLUSION: Our results suggest that Hartmann's operation is safe and may be usually performed in our conditions. However, near by amount colostomy and intra-operative colonic irrigation might be an alternating procedure in some selected @entity0 .

title: [Left XXXX in Ivory Coast].

answer: @entity4


abstract: An association between the @entity3 variant and an increased risk of @entity1 has been reported. Most previous studies were performed with clinically recruited @entity0 and controls. This approach may cause selection bias. The present analysis was performed with the aim to investigate the association between the @entity3 mutation and the risk of @entity2 in a population-based sample. The Study of Health in Pomerania (SHIP) is a survey that was carried out in North East Germany. A random sample from the population aged 20 to 79 years was taken. The total SHIP population comprised 4,310 @entity0 . The presence of the @entity3 variant was determined by PCR and Mnl I digestion. The presence of the @entity3 variant was neither associated with the number of pregnancies nor with the number of @entity0 per @entity0 . Data from 1,768 females who had at least one pregnancy with known outcome was available for the present analysis. Seventy-three @entity0 (4.1%) reported at least one @entity2 . @entity0 with and without the @entity3 mutation did not differ with respect to the number of @entity0 with at least one @entity2 (OR for @entity3 variant 1.57; 95%-CI 0.76 - 3.25). Furthermore, the number of @entity0 with two or more @entity2 , the number of @entity2 per affected @entity0 and the number of @entity2 per number of pregnancies per @entity0 was similar between both genotype groups. In conclusion, there is no association between the @entity3 mutation and the risk of @entity2 in a representative population sample.

title: XXXX and the risk of @entity2 in a German population.

answer: @entity3


abstract: BACKGROUND: @entity1 represent a group of @entity2 comprised of neuroendocrine cells. In 1999, the World Health Organization (W.H.O.) proposed the definitive classification of @entity2 based on the criteria from Travis and associates. The W.H.O. described two different groups of @entity2 : typical @entity4 (AC). Few reports have reviewed their data according to the current classification, and therefore, prognosis and standard therapy for TC and AC are still uncertain. METHODS: From 1980 to 2001, 98 pulmonary resections have been performed for primary @entity2 in our Thoracic Department of the University of Milan. We reviewed original histology using the current W.H.O. criteria and identified 88 @entity0 with TC and 10 with AC. We reviewed the outcomes in each group. RESULTS: The 5 year-overall survival rate was 91.9% for TC and 71% for AC. The 10-year overall survival rate was 89.7% for TC and 60% for AC. The 5-year @entity3 -related survival rates in the TC group were: IA-B, 100%; IIA-B, 75%; and IIIA, 50%. At 10 years, they were: IA-B, 100%; IIA-B, 75%; and IIIA, 0%. The 5-year survival rates in the AC group were: IA-B, 100%; IIA-B, 100%; and IIIA, 0%. At 10 years, they were: IA-B, 100%; IIA-B, 66%; and IIIA, 0%. CONCLUSIONS: Prognosis is favorable for both subtypes in the early stage. Advanced stages are related to better prognosis in TC. Recurrences rate is worse in the AC subtype. Our data suggest avoiding limited resections when feasible in AC. Parenchyma-sparing resections should be encouraged in TC.

title: Assessment of outcomes in XXXX according to latest WHO classification.

answer: @entity4


abstract: AIM OF THE STUDY: The aim of this study was to assess the oncology and functional outcome after preoperative radiotherapy and delayed coloanal @entity3 for @entity1 of the lower third of the rectum. @entity0 AND METHODS: From January 1988 to December 1997, 35 @entity0 received preoperative radiotherapy (45 Gy) followed by rectal resection through a combined abdominal and transanal approach. Thirty @entity0 had preoperative @entity1 staging with endorectal ultrasonography: uT1N0 = 2, uT2N0 = 6, uT2N+ = 2, uT3N0 = 6, and uT3N+ = 14. Colorectal resection was performed on average 32 days after the conclusion of radiotherapy, and the distal colon stump was pulled through the anal canal. On postoperative day 5, the colonic stump was resected and a direct coloanal @entity3 performed. RESULTS: Pathological examination of the specimens revealed @entity1 sterilization in two cases, pT1N0 = 3, pT2N0 = 14, pT2N+ = 1, pT3N0 = 6, and pT3N+ = 9. There was no postoperative mortality and there was no leakage. One @entity0 had a @entity4 , and another one had @entity2 which required re-operation. Median follow-up was 43 months (range 6-113). Two @entity0 had locoregional recurrence, seven had distant metastasis, and 3 had both. Actuarial survival rate at 1, 3 and 5 years was 97%, 86%, and 72% respectively. The rate of local control at 5 years was 78%. Functional results were evaluated by a new scoring system. Function was considered good in 59 and 70% at 1 and 2 years respectively. CONCLUSION: This new procedure is a safe and effective sphincter-preserving operation that avoids a diverting stoma. It is well adapted for @entity0 receiving preoperative radiotherapy, with low local morbidity and good functional results.

title: [Oncologic and functional results of resections with direct delayed coloanal @entity3 in previously irradiated XXXX of the lower rectum].

answer: @entity1


abstract: CONTEXT: Ten years after the use of alpha interferon in @entity5 ( @entity5 ) @entity2 treatment, we review this treatment. OBJECTIVE: We propose through this study to evaluate the therapeutic answer of the @entity0 reached of @entity5 in chronic phase and to study its impact on survival. MATERIAL AND METHODS: To be done we carried out a descriptive and analytical retrospective study concerning 40 @entity0 carrying @entity3 . RESULTS: The average age was 39.05 years and ratio sex was 0.9. 60% of the @entity0 profited from the arm @entity4 + Interferon alpha + @entity6 and 40% from @entity4 + @entity8 . The complete haematological answer was observed in 85.5%. The cytogenetic answer was documented only for two cases, and it acted of complete answer. On the evolutionary level, it was noted 27.5% of deaths related to a blastic transformation. The side effects were marked by occurred of @entity1 , @entity7 . The median of survival observed was 68.233 months or 5.68 years. The age, socioeconomic level, delay of treatment started, therapeutic protocol, length and regularity of treatment influenced the therapeutic response. CONCLUSION: Many factors influence the treatment response.

title: [Therapeutic impact of alpha interferon in chronic XXXX ].

answer: @entity2


abstract: UNASSIGNED: The aim of this study is to determine if thoracolumbar vertebral body collapse or canal compromise (CC) is associated with reposition of bone fragment. We retrospective review medical charts of @entity0 with thoracolumbar burst @entity1 from July 2010 to September 2013. The @entity1 were classified according to the Arbeit Fuer Osteoosynthese (AO) classification system. Neurological status was classified according to American @entity4 Association (ASIA). @entity0 were divided into two groups (reposition group and non-reposition group) according to whether the bone fragments were reposition or non-reposition after surgery. Mimics measured @entity6 ( @entity6 ), @entity5 ( @entity5 ), @entity2 ( @entity2 ) and @entity3 ratio (AVBCR), middle vertebral body compression ratio (MVBCR), posterior vertebral body compression ratio (PVBCR), and @entity6 compression ratio (MSDCR) on the preoperative CT image. The results indicated that 55 @entity0 were included in the study. There are 35 @entity0 with reposition of bone fragment and 20 @entity0 with non-reposition of bone fragment after surgery. There were significant difference on @entity6 (t = 3.258, P = 0.002), @entity5 (t = 2.197, P = 0.032), AVBCR (t = -2.063, P = 0.044), MVBCR (t = -2.526, P = 0.015), PVBCR (t = -2.211, P = 0.031), MSDCR (t = -4.975, P = 0.000) between two groups before surgery. There was a significant correlation between reposition of bone fragment and AO classification (OR = 5.251, P = 0.022), and MSDCR (OR = 7.366, P = 0.007). There was no significant correlation between reposition and AVBCR, MVBCR, PVBCR, @entity2 , @entity6 and @entity5 . In conclusion, this study indicates that AO classification and MSDCR are predictors of reposition of bone fragment.

title: Correlation of bone fragments reposition and related parameters in thoracolumbar burst XXXX @entity0 .

answer: @entity1


abstract: BACKGROUND: Many regimens of @entity1 - @entity4 chemotherapy have proven activity in @entity0 with advanced @entity5 ( @entity5 ). However, the optimal dose and schedule still have to be established. @entity0 AND METHODS: We conducted a phase II study with administration of @entity4 50 mg/m(2) on days 1 and 8 and @entity1 800 mg/m(2) on days 2, 9 and 15. This schedule was selected to optimise the synergism between the two drugs and reduce @entity2 due to high dose @entity4 . RESULTS: Thirty-six chemo-naive @entity0 with stage IIIA, IIIB or IV @entity5 entered the study (26 @entity0 , 10 @entity0 ; median age 58 years, range 29-74). Twenty @entity0 achieved a partial response: 7 out of 10 stage IIIA @entity0 , 7 out of 13 stage IIIB @entity0 and 6 out of 13 stage IV @entity0 . On intent-to-treat basis, the overall response rate (RR) was 58% (95% confidence interval, 42-74%). Ninety percent of stage IIIA @entity0 and 46% of stage IIIB @entity0 received adjuvant surgery or radiotherapy. Overall median duration of response was 28 weeks (range 6-147 weeks). For stage IIIA, IIIB and IV @entity0 , these numbers were 91, 13 and 23 weeks, respectively. One-year survival was 49% with 90%, 23% and 42% for stage IIIA, IIIB and IV @entity0 , respectively. The main @entity2 was myelosuppression. WHO grades 3 and 4 @entity6 occurred in 67% of @entity0 , whereas 61% experienced grade 3 or 4 @entity3 . Although hematological @entity2 was clinically tolerable, it frequently led to omission of @entity1 administration on day 15. The incidence of @entity7 was very low. CONCLUSION: This regimen of @entity4 on days 1 and 8 and @entity1 on days 2, 9 and 15 induced a high RR in @entity0 with advanced NCSLC. Frequent omission of @entity1 day 15 is a limitation of this schedule. This should be an important factor in a practical approach to decide on the most optimal schedule of the @entity4 plus @entity1 combination.

title: Combination of @entity1 and XXXX for advanced @entity5 : a phase II study with emphasis on scheduling.

answer: @entity4


abstract: Hematopoiesis undergoes several migrations from yolk sac to liver and spleen, and finally bone marrow until the end of life. A number of investigations have demonstrated that the hematopoietic microenvironment plays very important role in this process. However, the exact mechanisms remain unknown. In order to systematically analyze and understand the role of hematopoietic microenvironment in the regulation and control of hematopoiesis, a microarray containing 588 complementary DNAs was used to compare the gene expressions between those in @entity0 fetal liver and bone marrow cells. The results obtained from array hybridization were analyzed and reconfirmed by using bioinformatics and RT-PCR as well as Northern blot. The results showed that 65 and 131 genes were relatively high expressed in bone marrow and fetal liver cells respectively among 588 known genes in the array-membrane. According to the survey in the PubMed, 39 out of bone-marrow-expressed genes and 71 in fetal-liver-expressed genes were closely related to the hematopoiesis. Further reconfirmation by RT-PCR or Northern blot has demonstrated that @entity2 , @entity1 an d @entity3 genes chosen for analysis were highly expressed in adult bone marrow, but unexpressed or lower expressed in fetal liver cells, resulting in high similarity to the array results. Moreover, the expressions of @entity2 and @entity1 in fetal liver were down-regulated with the increment of gestational age. In conclusion, the gene expressions in bone marrow and fetal liver cells are obviously different, some of the genes are down-regulated at the different stages of ontogeny. The different gene expression levels between bone marrow and fetal liver, especially those genes closely related to the hematopoiesis, may be the molecular basis for the explanation of why hematopoietic stem cells derived from different tissues have different characterizations as well as the differences from the beginning and terminating of fetal liver hematopoiesis, and why hematopoietic stem cells derived from fetal liver is tremendously difficult to be grafted in bone marrow.

title: [Comparative study of differentially expressed genes in XXXX bone marrow and fetal liver cells].

answer: @entity0


abstract: PURPOSE: The International @entity2 Response Criteria (INRC) require serial measurements of @entity1 in three dimensions, whereas the Response Evaluation Criteria in @entity1 (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of @entity1 response assessment for use in revised INRC. @entity0 AND METHODS: @entity0 younger than 20 years with high-risk @entity2 were eligible if they were diagnosed between 2000 and 2012 and if three @entity1 measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as >=  30% reduction in longest dimension as per RECIST, >=  50% reduction in volume as per INRC, or >=  65% reduction in volume. RESULTS: Three-year event-free survival for all @entity0 (N = 229) was 44% and overall survival was 58%. The sensitivity of both volume response measures (ability to detect responses in @entity0 who survived) exceeded the sensitivity of the single dimension measure, but the specificity of all response measures (ability to identify lack of response in @entity0 who later died) was low. In multivariable analyses, none of the response measures studied was predictive of outcome, and none was predictive of the extent of resection. CONCLUSION: None of the methods of @entity1 response assessment was predictive of outcome. Measurement of three dimensions followed by calculation of resultant volume is more complex than measurement of a single dimension. @entity1 response in @entity0 with high-risk @entity2 should therefore be evaluated in accordance with RECIST criteria, using the single longest dimension.

title: Assessment of Primary Site Response in XXXX With High-Risk @entity2 : An International Multicenter Study.

answer: @entity0


abstract: Recently conducted clinical trials have provided impressive evidence that chemotherapy resistant metastatic @entity4 and several @entity5 can be cured using adoptive T cell therapy or T cell-recruiting bispecific antibodies. However, a significant fraction of @entity0 did not benefit from these treatments. Here we have evaluated the feasibility of a novel combination therapy which aims to further enhance the killing potential of bispecific antibody-redirected T lymphocytes by using these cells as targeted delivery system for photosensitizing agents. For a first in vitro proof-of-concept study, ex vivo activated @entity0 donor T cells were loaded with a @entity8 (PSS)-complex of the model photosensitizer 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin ( @entity9 ). In the absence of light and when loading with the water-soluble PSS/mTHPP-complex occurred at a tolerable concentration, viability and cytotoxic function of loaded T lymphocytes were not impaired. When "drug-enhanced" T cells were co-cultivated with @entity6 -expressing @entity0 @entity3 cells, mTHPP was transferred to target cells. Notably, in the presence of a bispecific antibody, which cross-links effector and target cells thereby inducing the cytolytic activity of cytotoxic T lymphocytes, significantly more photosensitizer was transferred. Consequently, upon irradiation of co-cultures, redirected drug-loaded T cells were more effective in killing A549 lung and SKOV-3 @entity2 cells than retargeted unloaded T lymphocytes. Particularly, the additive approach using redirected unloaded T cells in combination with appropriate amounts of separately applied PSS/mTHPP was less efficient as well. Thus, by loading T lymphocytes with a stimulus-sensitive anti- @entity1 drug, we were able to enhance the cytotoxic capacity of carrier cells. @entity7 cells could open new perspectives for adoptive T cell therapy as well as targeted photodynamic therapy.

title: A photosensitizer delivered by bispecific antibody redirected T lymphocytes enhances cytotoxicity against @entity6 -expressing XXXX cells upon light irradiation.

answer: @entity3