abstract: We examined whether plasma @entity7 levels and the beta- @entity7 gene G(-455)-->A polymorphism were related to microvascular or @entity2 in @entity0 (n = 909) with type 1 @entity1 enrolled in the @entity1 Control and Complications Trial/Epidemiology of @entity1 Interventions and Complications (DCCT/ EDIC). Univariate regression showed that @entity7 levels were correlated with BMI (r = 0.15; P < 0.0001), HbA(1c) (r = 0.11; P = 0.0014), total @entity3 (r = 0.17; P < 0.0001), and LDL @entity3 (r = 0.16; P < 0.0001) in all @entity0 . In @entity0 , but not @entity0 , waist-to-hip ratio (r = 0.20; P < 0.0001) and @entity6 (r = 0.13; P = 0.0047) also became powerful predictors of @entity7 level; in @entity0 , but not @entity0 , @entity7 was correlated with both diastolic (r = 0.16; P = 0.0011) and systolic (r = 0.11; P = 0.0241) blood pressure. @entity7 was correlated with urinary albumin excretion rates in @entity0 (r = 0.13; P = 0.0033), but not in @entity0 . In both sexes, however, the development of @entity4 (albumin excretion >300 mg/24 h) was accompanied by 1.5-fold increment in plasma @entity7 compared with @entity0 with normal excretion or microalbuminuria. In addition, high @entity7 levels were associated with a lower average ankle-brachial index in @entity0 (r = -0.13; P = 0.0075), but not @entity0 . Multiple regression analyses demonstrated that plasma @entity7 was independently correlated with high albumin excretion rate in @entity0 , and with low average ankle-brachial index in @entity0 . @entity7 was not correlated with the severity of @entity5 . Carotid artery intima-medial thickness was not correlated with @entity7 , and the G(-455)-->A polymorphism in the 5' promoter region of the beta- @entity7 gene did not influence circulating @entity7 levels. However, the presence of the more common G(-455) allele was associated with greater intima-medial thickness in the internal carotid artery (ANCOVA P = 0.045). Last, hyperfibrinogenemia in type 1 @entity1 is associated with components of the insulin resistance syndrome trait cluster, and the association is influenced by sex.

title: @entity7 is a marker for nephropathy and peripheral vascular disease in type 1 @entity1 : studies of plasma @entity7 and XXXX gene polymorphism in the DCCT/EDIC cohort.

answer: @entity7


abstract: OBJECTIVE: We sought to assess the early success and safety of catheter-directed, ultrasound-assisted (CDUA) thrombolysis for @entity7 ( @entity7 ) in @entity0 deemed to be "high risk" for thrombolytic therapy. METHODS: A retrospective evaluation of @entity0 who underwent CDUA pulmonary thrombolysis in our practice during 39 months is reported. There were 91 @entity0 considered, all of whom presented with acute @entity7 as diagnosed by computed tomography angiography. The ratio of the right ventricle to left ventricle diameter (RVaxial:LVaxial) was noted, as were preprocedure pulmonary artery pressures (PAPs). Demographic data, significant medical history, and procedure details were recorded. Standard thrombolysis protocol was followed (1 mg of tissue plasminogen activator per hour per catheter after an initial 2-mg bolus per catheter). Minitab 17 (Minitab Inc, State College, PA) was used for data analysis. RESULTS: There were 91 @entity0 who had a computed tomography diagnosis of acute @entity7 and @entity2 (PAP >25 mm Hg). Seventeen @entity0 (19%) were deemed to be at high risk for @entity4 , predicted by recent @entity4 , major surgery within 3 weeks, acute @entity5 , and @entity8 with cardiopulmonary resuscitation within 1 week. The high-risk @entity0 in our study were noted to have higher RV:LV ratios and lower @entity1 saturations on admission (P  < .05). On computed tomography angiography, the mean pretherapy RVaxial:LVaxial ratio was 1.5     0.4. The mean pretherapy PAP was 56.2     15.2 mm Hg. After 18.5     3.5 hours of thrombolysis, the mean post-therapy PAP was 34.3     10.4 mm Hg, with a pressure drop of 21.9     4.8 mm Hg (39% decrease; P  < .001). In total, seven @entity0 (8%) suffered @entity4 complications that required intervention-four @entity3 , a @entity9 , and one gross @entity6 . Three of the seven complications occurred in the high-risk group (3/17) and the other four in the general population of @entity0 (4/74; P  = .118). Minor @entity4 complications (n  = 14 [15%]) did not require intervention and included puncture site @entity9 , ecchymosis, and mild traumatic @entity6 . Considering all @entity4 complications, increasing RVaxial:LVaxial ratio was a predictor of any @entity4 complication, independent of all risk factors (P  = .005). CONCLUSIONS: CDUA thrombolysis for acute @entity7 effectively reduced mean PAPs. Given the low incidence of major @entity4 complications, even in those deemed to be clinically at high risk for @entity4 , we additionally conclude that this procedure can be performed safely. Although larger studies with longer follow-up are necessary, CDUA pulmonary thrombolysis for the management of acute submassive @entity7 appears to be effective in decreasing right-sided heart strain and can be performed with an acceptable risk profile.

title: Catheter-directed, ultrasound-assisted thrombolysis is a safe and effective treatment for @entity7 , even in high-risk XXXX .

answer: @entity0


abstract: UNASSIGNED: Background Malaria treatment is recommended for @entity0 with suspected @entity4 ( @entity4 ) in West Africa, whether systeomatically or based on confirmed @entity2 diagnosis. At the Ebola treatment center in Foya, Lofa County, Liberia, the supply of @entity5 - @entity6 , a first-line antimalarial combination drug, ran out for a 12-day period in August 2014. During this time, @entity0 received the combination drug @entity3 - @entity7 ; @entity7 is a compound with anti-Ebola virus activity in vitro. No other obvious change in the care of @entity0 occurred during this period. Methods We fit unadjusted and adjusted regression models to standardized @entity0 -level data to estimate the risk ratio for @entity1 among @entity0 with confirmed @entity4 who were prescribed @entity3 - @entity7 ( @entity3 - @entity7 group), as compared with those who were prescribed @entity5 - @entity6 ( @entity5 - @entity6 group) and those who were not prescribed any antimalarial drug (no-antimalarial group). Results Between June 5 and October 24, 2014, a total of 382 @entity0 with confirmed @entity4 were admitted to the Ebola treatment center in Foya. At admission, 194 @entity0 were prescribed @entity5 - @entity6 and 71 were prescribed @entity3 - @entity7 . The characteristics of the @entity0 in the @entity3 - @entity7 group were similar to those in the @entity5 - @entity6 group and those in the no-antimalarial group. A total of 125 of the 194 @entity0 in the @entity5 - @entity6 group (64.4%) died, as compared with 36 of the 71 @entity0 in the @entity3 - @entity7 group (50.7%). In adjusted analyses, the @entity3 - @entity7 group had a 31% lower risk of @entity1 than the @entity5 - @entity6 group (risk ratio, 0.69; 95% confidence interval, 0.54 to 0.89), with a stronger effect observed among @entity0 without @entity2 . Conclusions @entity0 who were prescribed @entity3 - @entity7 had a lower risk of @entity1 from @entity4 than did @entity0 who were prescribed @entity5 - @entity6 . However, our analyses cannot exclude the possibility that @entity5 - @entity6 is associated with an increased risk of @entity1 or that the use of @entity3 - @entity7 was associated with unmeasured @entity0 characteristics that directly altered the risk of @entity1 .

title: Effect of @entity3 - XXXX on Mortality Related to @entity4 .

answer: @entity7


abstract: PURPOSE: @entity6 are lesions marked by a disorganized arrangement of mature neural elements and represent a rare cause of medically intractable @entity5 . We present the clinical presentation and imaging findings of this rare entity. METHODS: History and neurophysiological studies of 14 @entity0 with pathologically confirmed @entity6 who had surgery for intractable @entity5 were reviewed. MRIs were available for review in 10 @entity0 . RESULTS: The lesions were most commonly located in the @entity4 . @entity3 semiology was concordant with the anatomic location of the @entity6 in all @entity0 . Nine of the thirteen @entity0 (69%) with the @entity6 confined to one lobe had interictal spikes and sharp waves at the corresponding electrodes. The ictal pattern was confined to the same lobe of the @entity6 in five of nine @entity0 with ictal recordings. Although imaging characteristics were variable, all @entity0 had signal increase on T2-weighted images and 50% of them had mild mass effect. Neocortical involvement was present in the majority of @entity0 (7/10), blurring of the gray/white matter interface was seen in seven @entity0 . Five of those seven @entity0 were found to have associated @entity7 by pathology. CONCLUSION: @entity6 represent a rare entity and may cause devastating @entity2 . Imaging characteristics are difficult to distinguish from those of some other developmental @entity1 . @entity6 are frequently associated with microscopic @entity7 ( @entity7 ), thus underlining their malformative etiology.

title: @entity6 and XXXX : clinical and imaging characteristics.

answer: @entity2


abstract: BACKGROUND: Antibiotic resistance typically confers a biological fitness cost on bacteria that can be manifested as a decreased growth rate in culture media and experimental animals. However, there are limited experimental data on the relative fitness of resistant and susceptible bacteria during growth in their natural environment. OBJECTIVE: We have developed a @entity0 competition model to investigate the relative fitness of antibiotic-resistant and -susceptible bacteria. MATERIALS AND METHODS: A non-epidemic @entity3 was isolated from skin, and a @entity1 -resistant (RifR) clone was selected. The RifR marker was used to distinguish the inoculated strains from the resident population of coagulase-negative staphylococci. The RifR strains were further selected for resistance to @entity2 (CipR) and @entity4 (FusR). A 1:1 mix of susceptible and resistant bacteria was applied on the forearms of 12 volunteers. Competition was monitored by sampling bacteria from skin and determining their relative numbers. RESULTS: Resistance to @entity2 due to @entity5 mutations did not decrease the growth rate in vitro, and the CipR/CipS ratio was close to 1 during day 1 and 3 in the in vivo competition experiments. In contrast, @entity4 resistance due to fusA mutations resulted in a decrease in the growth rate in vitro and a considerable loss of fitness in the competition. The FusR/FusS ratio diminished from 1.3 to 0.023 in 3 days. CONCLUSIONS: These data show that @entity0 volunteers can be used as a simple and relevant model to study the biological cost of resistance.

title: Fitness of antibiotic resistant XXXX assessed by competition on the skin of @entity0 volunteers.

answer: @entity3


abstract: OBJECTIVE: To compare the relative effectiveness of the Polysymptomatic Distress Scale (PSD) with the Symptom Impact Questionnaire (SIQR), the disease-neutral revision of the updated @entity2 Impact Questionnaire (FIQR), in their ability to assess disease activity in @entity0 with @entity3 both with and without @entity2 ( @entity2 ). METHODS: The study included 321 @entity0 from 8 clinical practices with some 16 different @entity4 . Disease severity was assessed by the Medical Outcomes Study Short Form-36 (SF-36). Univariate analyses were used to assess the magnitude of PSD and SIQR correlations with SF-36 subscales. Hierarchical stepwise regression was used to evaluate the unique contribution of the PSD and SIQR to the SF-36. Random forest regression probed the relative importance of the SIQR and PSD components as predictors of SF-36. RESULTS: The correlations with the SF-36 subscales were significantly higher for the SIQR (0.48 to 0.78) than the PSD (0.29 to 0.56; p < 0.001). Stepwise regression revealed that the SIQR was contributing additional unique variance on SF-36 subscales, which was not the case for the PSD. Random forest regression showed SIQR Function, Symptoms, and Global Impact subscales were more important predictors of SF-36 than the PSD. The single SIQR @entity1 item contributed 55% of SF-36 @entity1 variance compared to 23% with the 19-point WPI (the @entity1 ). CONCLUSION: The SIQR, the disease-neutral revision of the updated FIQ, has several important advantages over the PSD in the evaluation of disease severity in @entity4 .

title: Evaluating Disease Severity in @entity4 @entity0 with and without XXXX : A Comparison of the Symptom Impact Questionnaire and the Polysymptomatic Distress Scale.

answer: @entity2


abstract: BACKGROUND: Overweight and @entity1 decrease the effectiveness of antihypertensive therapy despite the more frequent use of polytherapy. One method for improving therapy effectiveness is by decreasing non-compliance with the use of @entity3 ( @entity3 ). The aim of this study was to assess the effectiveness, tolerance, and satisfaction with @entity4 / @entity5 @entity3 antihypertensive therapy in relation to nutritional status. METHODS: The survey enrolled 24,240 @entity2 @entity0 recently switched to @entity4 / @entity5 @entity3 (EGIRAMLON) at the same doses as previously prescribed separate pills. RESULTS: The effectiveness of antihypertensive therapy increased during follow-up from 32.9% to 76.5%. Overweight and @entity1 were associated with the increased risk of not attaining the recommended BP values [adjusted for age OR=0.74 (95% CI 0.67-0.83) and 0.70 (0.61-0.81) for overweight; 0.54 (0.47-0.60) and 0.49 (0.42-0.57) for @entity1 , at the first and the second examination, respectively]. "Very good" or "good" the FDP tolerance was reported by 98.8%, 97.6% and 96.4%, respectively. Adverse events (AE) were reported in 0.35% of @entity0 regardless of nutritional status. High levels of satisfaction with the @entity3 were reported by 57.0% of @entity0 with normal weight, 54.5% of overweight, and 50.6% with @entity1 . Effectiveness and convenience were the most important for @entity0 . CONCLUSIONS: The effectiveness of therapy with @entity4 / @entity5 @entity3 in the study population was high, but slightly lower in overweigh and @entity1 . This @entity3 was well tolerated and a significant number of @entity0 satisfied with the therapy regardless of nutritional status. Although the perceived tolerance and satisfaction with treatment were lower in @entity1 and overweight than in normal weight @entity0 ; the incidence of AE and perceived benefit from the use of a single-pill, compared to multiple tablets, were comparable irrespective of nutritional status.

title: @entity4 / XXXX single pill - Effectiveness, tolerance and @entity0 satisfaction with antihypertensive therapy in relation to nutritional status.

answer: @entity5


abstract: @entity0 with @entity9 have a twofold to fourfold increased risk of dying from the complications of @entity3 . @entity8 and vascular @entity7 are major contributors. The increased risk is present before fasting @entity12 is seen. These individuals often have a sedentary life-style, poor physical conditioning, @entity11 resistance, @entity2 , @entity5 , @entity10 , and a prothrombotic state. @entity12 is then added to these risk markers. Microalbuminuria may precede @entity12 in @entity9 , occurs in 30% to 40% of these individuals after @entity1 is established, and is a predictor of cardiovascular events. Early intervention in high-risk individuals may delay or prevent fasting @entity12 . An all-inclusive approach that focuses on early risk factor (or marker) identification and management to prevent or delay accelerated @entity8 and @entity7 in @entity9 is an attractive strategy. However, the database to support this strategy is limited. In particular, large-scale prospective trial data are not available to support the concept of intensive glycemic regulation to prevent progression of @entity4 in @entity9 . This is in contrast to the situation regarding microvascular disease of the eyes and kidneys. Recently, indirect data of a correlative nature have emerged, and short- and long-term prospective trials at early and late stages of @entity9 are now being reported. These studies are analyzed and interpreted in this report. In contrast, the database to support an intensive antiplatelet regimen to prevent vascular @entity7 events in @entity0 with @entity9 is large, and these studies are reviewed. They are of a type and magnitude to allow definite recommendations for aspirin therapy in @entity9 . Aggressive therapy directed at @entity5 , @entity6 , and elevated urinary albumin in @entity0 with @entity9 appears to be indicated. Increased attention to the multifactorial aspects of treatment of the type II @entity1 @entity0 is needed. Our present challenge is to translate these findings for @entity0 and primary health care providers so that effective actions may be implemented.

title: Multifactorial aspects of the treatment of the type II XXXX @entity0 .

answer: @entity1


abstract: @entity0 with @entity3 were given repeated cycles consisting of infusions of @entity2 followed by "rescue" with @entity5 . Peripheral blood leukemic cells were harvested from @entity0 before cyclical treatment, and the rates of incorporation of @entity1 and of @entity7 into @entity4 (DNA) were measuared in vitro. There was no relationship between the pretreatment incorporation of either @entity8 into DNA and the clinical response to therapy. @entity2 suppressed @entity7 incorporation into DNA by the leukemic blasts in vitro, but the @entity0 whose cells were most sensitive to this effect did not necessarily go into remission when treated. Leukemic cells were sampled during @entity2 infusions and the @entity8 incorporation rates were determined. @entity1 incorporation into DNA was variably affected. If, by the end of the first infusion, it remained elevated, remission rarely followed, whereas if it was below the pretreatment value, remission was much more likely. In all cases, @entity7 incorporation was suppressed during the infusion. The greatest suppression occurred in @entity0 who went on to remission, but the suppression did not correlate with that expected from pretreatment in vitro tests unless due weight was given to the concomitant effects of the @entity2 therapy on @entity1 incorporation. Leukemic blasts surviving successive cycles of therapy became progressively more resistant to the suppressing effects of @entity2 in vitro. This resistance became especially marked in the blasts of @entity0 who did not go into remission. During @entity2 infusions, inhibition of leukemic cell @entity6 reductase activity was greatest in blasts of @entity0 whose disease subsequently remitted.

title: Treatment of leukemia with large doses of @entity2 and XXXX : clinical-biochemical correlates.

answer: @entity5


abstract: BACKGROUND: Very little is known about the pharmacokinetics of chemotherapeutic agents in @entity0 also being treated with continuous ambulatory peritoneal dialysis. We sought to evaluate the pharmacokinetics of @entity3 and @entity5 in plasma and peritoneal dialysate in a @entity0 being treated for @entity1 . METHODS: A single @entity0 with @entity1 and on peritoneal dialysis for @entity2 was treated with @entity3 25  mg/m(2) on day 1 of weeks 1 and 5 and continuous infusional @entity5 1000  mg/m(2)/day on days 1-4 of weeks 1 and 5 along with daily radiation therapy. Intense plasma and dialysate sampling was performed during the week 5 administration, followed by quantitation of @entity4 by atomic absorption spectrophotometry and @entity5 by LC-MS/MS. RESULTS: Following systemic administration, clearance of ultrafilterable (active) @entity4 over the first 6  h was 20.8  L/h, which is lower than previously reported clearance levels of ultrafilterable @entity4 . Total @entity4 AUC was 131   g  h/mL, also higher than an AUC previously reported for total @entity4 in @entity0 with normal renal function. @entity4 -related material was detected in the peritoneal cavity, but this is likely inactive. @entity5 penetrated the intraperitoneal cavity, but the contribution of peritoneal dialysis to drug clearance was negligible at 0.072  %. CONCLUSIONS: Administration of intravenous @entity3 and @entity5 chemotherapy to a @entity0 treated with continuous ambulatory peritoneal dialysis is feasible, but clearance in dialysate is nominal, thus suggesting that dose reduction is indicated for @entity3 . Systemic drug administration results in limited intraperitoneal penetration of @entity5 and inactive @entity4 species.

title: A pharmacokinetic analysis of XXXX and @entity5 in a @entity0 with esophageal cancer on peritoneal dialysis.

answer: @entity3


abstract: OBJECTIVE: To describe methods, recruitment success, and 1-y results of a study evaluating the effectiveness of phone- and mail-based weight-loss interventions in a managed care setting. DESIGN: Randomized clinical trial with three groups, that is, usual care, mail intervention, and phone intervention. SUBJECTS: In total, 1801 overweight members of a managed-care organization (MCO). MEASUREMENTS: Height, weight, medical status, and weight-loss history were measured at baseline. Participation in intervention activities was monitored for 12 months in the two active treatment groups. Self-reported weight was obtained at 6 and 12 months. RESULTS: More individuals assigned to mail treatment started it (88%) than did those assigned to phone treatment (69%). However, program completion rates were higher in the phone (36%) than mail (7%) intervention. The mean weight losses were 1.93, 2.38, and 1.47 kg at 6 months in the mail, phone, and usual care groups, respectively. The differences between the phone and usual care groups were statistically significant. The mean weight losses at 12 months did not differ by treatment group (2.28 kg mail, 2.29 kg phone, and 1.92 kg usual care). Greater @entity2 was seen in @entity0 , older @entity0 , and those with no prior experience in a weight-loss program. Heavier @entity0 and those who reported current treatment for @entity1 lost less weight. CONCLUSION: Although mail- and phone-based weight-loss programs can be delivered to large numbers of @entity0 in an MCO setting, additional work is needed to enhance their clinical efficacy as well as to assess their costs.

title: Mail and phone interventions for XXXX in a managed-care setting: Weigh-To-Be one-year outcomes.

answer: @entity2


abstract: BACKGROUND: Only a minority of @entity0 with @entity1 ( @entity1 ) have access to pulmonary rehabilitation (PR). Home-based solutions such as telehealthcare, have been used in efforts to make PR more available. The aim of this systematic review was to investigate the effects of telehealthcare on physical activity level, physical capacity and @entity2 in @entity0 with @entity1 , and to describe the interventions used. METHODS: Randomized controlled trials were identified through database searches, reference lists and included authors. Articles were reviewed based on eligibility criteria by three authors. Risk of bias was assessed by two authors. Standardized mean differences (SMD) or mean differences (MD) with 95% CI were calculated. Forest plots were used to present data visually. RESULTS: Nine studies (982 @entity0 ) were included. For physical activity level, there was a significant effect favoring telehealthcare (MD, 64.7  min; 95% CI, 54.4-74.9). No difference between groups was found for physical capacity (MD, -1.3  m; 95% CI, -8.1-5.5) and @entity2 (SMD, 0.088; 95% CI, -0.056-0.233). Telehealthcare was promoted through phone calls, websites or mobile phones, often combined with education and/or exercise training. Comparators were ordinary care, exercise training and/or education. CONCLUSIONS: The use of telehealthcare may lead to improvements in physical activity level, although the results should be interpreted with caution given the heterogeneity in studies. This is an important area of research and further studies of the effect of telehealthcare for @entity0 with @entity1 would be beneficial. REGISTRATION: In PROSPERO 2012: CRD42012003294. Study protocol: http://www.crd.york.ac.uk/PROSPEROFILES/3294_PROTOCOL_20121016.pdf.

title: Telehealthcare in XXXX : A systematic review and meta-analysis on physical outcomes and @entity2 .

answer: @entity1


abstract: @entity5 ( @entity8 ) has been shown to attenuate cytokine release from LPS-stimulated @entity0 peripheral blood mononuclear cells; however, the in vivo antiinflammatory effect of @entity8 in polymicrobial sepsis and @entity3 is unknown. This study evaluates the effect of @entity8 on inflammatory cytokine release and the pathways that may mediate antiinflammatory effects of @entity8 in the lung. Either 0.75 g/kg of @entity8 or saline placebo (SP) was administered to male @entity1 1 h after cecal ligation and puncture (CLP). NF-kappaB activation, IKBalpha degradation, phosphorylation of @entity6 MAPK, @entity7 , and @entity11 expression were evaluated in lung tissue 6 h post-CLP. Lung tissue iNOS and @entity10 , @entity2 , @entity4 , and @entity9 cytokines were assayed. Last, lung histopathology for occurrence of @entity3 and survival were examined. @entity8 given 1 h postsepsis led to inhibition of lung tissue NF-kappaB activation (P < 0.001 vs. SP), attenuated degradation of IKBalpha, and inhibited phosphorylation of @entity6 MAPK, and @entity7 , pathways critical for cytokine release. @entity8 treatment increased @entity11 peptide expression and significantly attenuated @entity2 and @entity4 6 h after CLP. @entity9 was attenuated by @entity8 at multiple time points post-CLP. Further, @entity8 abrogated increases in lung iNOS expression and enhanced lung @entity10 postsepsis. Finally, @entity8 prevented the histopathologic appearance of @entity3 after sepsis and significantly improved survival. These data reveal that @entity8 exerts an antiinflammatory effect in sepsis that may be mediated via attenuation of multiple pathways of inflammation such as NF-kappaB, @entity6 MAPK, @entity7 , and @entity11 . @entity8 also showed an inhibition of increases in iNOS expression. The antiinflammatory effect of @entity8 was associated with attenuation of @entity3 and mortality.

title: GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS XXXX ( @entity3 ) FOLLOWING SEPSIS.

answer: @entity3


abstract: OBJECTIVE: @entity1 is a common manifestation of systemic @entity2 . Apart from traditional risk factors, genetic determinants, such as polymorphisms of the @entity3 angiotensin system (RAS), may be relevant in modulating the @entity2 process leading to @entity1 . In this study, we investigated the role of @entity4 ( @entity4 ) I/D and @entity9 , @entity5 ( @entity5 ) @entity6 , and angiotensin type 1 receptor ( @entity7 ) @entity8 polymorphisms in modulating the susceptibility to the disease. METHODS: Eight hundred twenty-one consecutive @entity0 with severe @entity1 (>= 70%) and 847 control subjects were investigated. RESULTS: A significant difference in genotype distribution (P < .0001) and allele frequency (P < .0001) between @entity0 and controls for the @entity4 I/D polymorphism, but not for the other single-nucleotide polymorphisms investigated, was observed. The @entity4 D allele frequency was significantly higher in @entity0 without traditional risk factors in comparison with that observed in those with at least one risk factor (0.71 vs 0.61; P = .04). The @entity4 D allele significantly influenced @entity1 under dominant, recessive, and additive model of inheritance at both univariate (P < .0001) and multivariate analysis (P < .0001). When the combined effect of RAS unfavorable alleles was considered, @entity0 carrying less than three alleles had a lower risk of @entity1 (odds ratio [OR], 0.79 [0.63-0.99]; P = .05), while carriers of more than four unfavorable alleles had an increased risk (OR, 1.44 [1.12-1.84]; P = .004), in comparison with subjects carrying three or four unfavorable alleles. @entity4 D allele frequency was similar in @entity0 with and without additional @entity2 localizations (0.61 vs 0.62, respectively). CONCLUSIONS: Our findings evidence a role for @entity4 I/D polymorphism in influencing the susceptibility to @entity1 , even in the absence of traditional risk factors. Interestingly, our findings provided further information concerning the role of this polymorphism in modulating the @entity2 process apart from its different localizations.

title: Association between polymorphisms of the @entity3 angiotensin system and XXXX .

answer: @entity1


abstract: OBJECTIVE: To describe the diagnostic yield and prognosis for @entity0 with @entity2 . BACKGROUND: The aetiology, utility of diagnostic procedures, and outcome of @entity2 in @entity0 with @entity7 having only subjective @entity6 on examination is unknown. METHODS: @entity0 were prospectively identified with @entity2 in a tertiary care institution from 1998-2002. Diagnostic procedures were analysed for sensitivity and clinical follow up was performed. RESULTS: Thirty four @entity0 , 25 (74%) @entity0 , of age 35 (SD 11) years were identified. The @entity2 occurred on the left side in 23 (68%) cases. Neuroimaging of the brain demonstrated @entity3 representing ischaemic aetiology in one case. Other diagnostic testing including cerebrospinal fluid examination, electrophysiological testing, carotid ultrasonography, echocardiography, and blood testing revealed no @entity3 . Sixteen @entity0 (47%) continued to complain of hemisensory difficulties after all investigations were completed at 9.6 (5.8) days. One @entity0 with a history of @entity4 and positive antiphospholipid antibodies had a second event diagnosed as @entity1 seven months after presentation. Clinical follow up at 16 (7) months revealed persisting symptoms in 6 (20%) of 30 @entity0 . Six (50%) of 12 @entity0 agreeing to psychiatric assessment received diagnoses of @entity5 . CONCLUSIONS: Diagnostic yield in @entity2 is low, and prognosis is almost always uniformly benign. The author advocates careful assessment of medical history and consideration for neuroimaging in this group of @entity0 .

title: XXXX is associated with a low diagnostic yield and a nearly uniform benign prognosis.

answer: @entity2


abstract: The extensive use of invasive procedures and of long-term @entity10 prophylaxis in the management of cirrhotic @entity0 may have influenced the epidemiology of @entity9 in @entity1 . We conducted a prospective evaluation of all @entity9 diagnosed in @entity0 with @entity1 in a Liver Unit between April 1998 and April 2000. A total of 405 @entity0 presented 572 @entity9 in 507 admissions. @entity5 was the most frequent @entity4 (138 cases). Gram-positive cocci were responsible for 53% of total @entity9 in the study, being the main bacteria isolated in @entity6 (59%). @entity0 requiring treatment in an intensive care unit and those submitted to invasive procedures presented a higher rate of @entity4 caused by gram-positive cocci (77% vs. 48%, P <.001 and 58% vs. 40%, P <.02, respectively). Fifty percent of culture-positive spontaneous @entity5 in @entity0 on long-term @entity10 administration (n = 93) and 16% in @entity0 not receiving this therapy (n = 414) were caused by @entity8 -resistant gram-negative bacilli, P =.01. The rate of culture-positive spontaneous @entity5 caused by @entity2 - @entity3 -resistant gram-negative bacilli was also very high in @entity0 on long-term @entity10 administration (44% vs. 18%, P =.09). In conclusion, @entity4 caused by gram-positive cocci have markedly increased in @entity1 . This phenomenon may be related to the current high degree of instrumentation of cirrhotic @entity0 . @entity8 -resistant spontaneous @entity5 constitutes an emergent problem in @entity0 on long-term @entity10 prophylaxis, with @entity7 not being a valid alternative.

title: @entity9 in @entity1 : epidemiological changes with invasive procedures and XXXX prophylaxis.

answer: @entity10


abstract: OBJECTIVE: To determine the incidence of @entity6 in workers following @entity4 in the work place, to define its relationship to the site, severity of injury and direction of force. The demographics of head injured workers were also assessed to determine if those with olfactory loss were more likely to have sustained a @entity1 . METHODS: 3438 consecutive @entity0 referred from the Workplace Safety and Insurance Board (WSIB) in the province of Ontario who sustained a work related @entity4 were assessed between 1987-2014 for olfactory and @entity3 at a tertiary referral university hospital. RESULTS: @entity6 ( @entity6 ) was identified in 413 of 3438 @entity0 (12.0%) of which 321 were diagnosed with @entity6 and 92 with @entity7 . In our series, injuries from a fall were the commonest cause for @entity6 and a frontal or mid-face impact was more likely to result in @entity6 than other regions [p=0.0002]. A @entity5 ( @entity5 ) of any duration correlated with @entity6 . In those with @entity6 , an associated skull @entity2 occurred in 37.1% of @entity0 and a CSF leak in 4.1%, which was significantly higher compared, to those without @entity6 (<0.0001). @entity0 with @entity6 had a higher incidence of cochlear and vestibular loss (19.9% and 20.6% respectively) compared to those without @entity6 (14.3% and 17.1% respectively). CONCLUSIONS: Post traumatic @entity6 is more likely to occur in @entity0 who experienced a moderate to severe @entity4 , @entity5 and more likely to result from a frontal or mid-face blow to the skull. @entity3 is likely to occur concurrently with @entity6 . This article is protected by copyright. All rights reserved.

title: Olfactory and XXXX after @entity4 in the workplace: an updated series.

answer: @entity3


abstract: AIM: To determine the activity of @entity2 dismutase, @entity7 and the concentration of @entity3 ( @entity5 ) in @entity6 , lens and red blood cells after application of @entity8 ( @entity9 ) into vitreous of @entity1 . MATERIAL AND METHODS: 0.5 ml of 100% SF6 was injected into the vitreous of 24 @entity1 of New Zealand race. The animals were randomly divided into 3 groups (of 8 @entity1 each) depending on the observation day: group 1-2nd day of experiment, group 2-7th day and group 3-14th observation day. The control group (gr. 0) consisted of 6 @entity1 that did not undergo any operations. Activity of @entity2 dismutase, @entity7 and @entity5 concentration were determined in @entity4 . RESULTS: On the 7th day of observation an increased activity of dismutase and @entity7 as well as simultaneous increased @entity5 concentration were observed. In the lens on the 7th day the increased activity of dismutase was significant in relation to the results in the next time interval, whereas @entity5 concentration was significantly lower in all time intervals of the experiment in comparison with control group. In erythrocytes an increased activity of @entity7 was noticed on the 2nd and 14th day. CONCLUSIONS: Increased occurrence of active @entity0 species in @entity6 leads to insufficiency of the antioxidant system and intensification of peroxidation processes, which is reflected by increased @entity5 concentration. However, in the lens of this experimental model a slight stimulation of antioxidant system by a small number of free radicals is observed, which provokes a reaction of sweeping them away. Efficiency of lens antioxidant system is secured by weakening of peroxidation processes, which is expressed in minimal drop of @entity5 concentration.

title: [Changes in the antioxidant system of the @entity6 , lens and erythrocytes after @entity8 application to the vitreous of XXXX ].

answer: @entity1


abstract: BACKGROUND/PURPOSE: The purpose of this systematic review is to update the available data for complications following orthognathic surgery in @entity9 @entity0 . METHODS: Three electronic databases (Medline, Embase, and Cochrane) were searched for publications from 1990 to 2014. RESULTS: A total of 26 articles were selected including 1003 @entity0 (male: 391, female: 353, 259: not mentioned) who underwent @entity10 for @entity9 . Mean age at surgery was 19.3 years (range: 8.5-60 years). Overall perioperative complications were reported in 126 cases (12.76%). The most common complication was closure failure of pre-existing palatal @entity3 (28.57%), followed by @entity1 (16.79%), closure failure of pre-existing @entity3 (10.74%), @entity7 (4.55%), and @entity2 stabilization in bilateral cases (4.55%). Severe @entity5 included one @entity8 (0.10%), one maxillary @entity4 (0.10%), and one cavernous sinus @entity6 (0.10%). Mean horizontal relapse rate was 17.9% (range: -20.0% to 37.2%), and mean vertical relapse rate was 35.4% (range: -25.9% to 162.5%). Reoperation rate was 12.2% (range: 0.0-64.0%). Prospective studies or randomized trials were rare. CONCLUSION: To obtain a dataset with higher evidence, a prospective multicenter study should be conducted with clearly defined criteria for each complication.

title: Complications following orthognathic surgery for @entity0 with XXXX : A  systematic review.

answer: @entity9


abstract: INTRODUCTION: Lymphovascular invasion (LVI) is a histopathological feature that is associated with an increased risk for micrometastasis. The aim of this study was to determine the prognostic and staging value of LVI among @entity0 with @entity4 ( @entity4 ) undergoing esophagectomy. METHODS: A prospective database of @entity0 with @entity4 was used to retrospectively analyze 666 cases to identify the relationship between LVI and survival, and to evaluate predictive accuracy of prognosis after combining LVI and the @entity2 , node, and @entity1 (TNM) system. Pathological slides were reassessed by gastrointestinal pathologists according  to the strict criteria; 1000-bootstrap resampling was used for internal validation, and 222 cases from an independent multicenter database were used for external validation. RESULTS: LVI was present in 33.8% of @entity0 , and the proportion increased with advancing T and N classification. LVI was an independent predictor of unfavorable @entity3 ( @entity3 ) (hazard ratio  = 1.59, 95% confidence interval: 1.30-1.94) and @entity3 ( @entity3 ) (hazard ratio  = 1.62, 95% confidence interval: 1.32-1.98) after T classification. Among node-negative @entity0 , LVI and T classification were two independent predictors of @entity3 and @entity3 (p < 0.001). The risk score model combing LVI and T classification improved the predictive accuracy of the TNM system for @entity3 and @entity3 by 3.5% and 4.8%, respectively (p < 0.001). The external validation showed congruent results. The @entity3 of TxN0MO disease with LVI was similar to the @entity3 of TxN1M0 (both p > 0.05). In contrast, LVI was not associated with @entity3 or @entity3 among node-positive @entity0 . CONCLUSIONS: The independent prognostic significance of  LVI existed only in node-negative @entity0 with @entity4 , and  the combination of LVI and the TNM system enhanced the  predictive accuracy of prognosis. After confirmation, node-negative @entity0 with LVI might be considered for upstaging in pathological staging.

title: Identification and Validation of Lymphovascular Invasion as a Prognostic and Staging Factor in Node-Negative XXXX .

answer: @entity4


abstract: @entity3 may occur secondarily to @entity1 or independently. The course of @entity3 is not known in either type. Twenty-one @entity3 @entity0 were included in this study (13 females, 8 males). The @entity0 were divided into two groups according to the presence or absence of @entity1 . In the group (11 @entity0 ) of @entity3 which was secondary to @entity2 were partially improved in 5 @entity0 who had controlled @entity1 , although it was difficult to control @entity1 with insulin or oral hypoglycemics in such @entity0 . @entity3 appeared insidiously in nine of these eleven @entity0 . The posterior neck was involved, but the face was not. In @entity0 without @entity1 , the @entity3 lesions began acutely in eight of ten of them. The course of the disease was usually stationary rather than showing acute improvement. Facial involvement was found in half of all the @entity0 . In conclusion, @entity3 @entity0 with @entity1 may improve if their @entity1 is controlled, and facial involvement may be related to @entity3 without @entity1 .

title: A clinical observation of XXXX and its relationship to @entity1 .

answer: @entity3


abstract: UNASSIGNED: @entity4 aerobically respires with several terminal oxidases. The @entity2 oxidase (Cyo) encoded by cyoABCD is needed for efficient adaptation to low @entity0 conditions, and cyo transcription is up-regulated at low @entity0 . This study sought to determine how transcription of the cyo operon is regulated. The 5' sequence upstream of cyo was analyzed in silico and revealed putative binding sites for ActR of the ActSR two-component regulatory system. The expression of cyo was decreased in an actSR mutant regardless of the @entity0 condition. Because ActSR is known to be important for growth at low pH in another rhizobial species, the effect of growth-medium pH on cyo expression was tested. As the pH of the media was incrementally decreased, cyo expression gradually increased in the wild type, eventually reaching approximately 10-fold higher levels at low pH (4.8) compared to neutral pH (7.0) conditions. This up-regulation of cyo under decreasing pH conditions was eliminated in the actSR mutant. Both the actSR and cyo mutants had severe growth defects at low pH (4.8). Lastly, the actSR and cyo mutants had severe growth defects when grown in media treated with an @entity1 chelator. In this condition, cyo was up-regulated in the wild type whereas cyo was not induced in the actSR mutant. Altogether, the results indicate cyo expression is largely dependent on the ActSR 2-component system. This study also demonstrates additional physiological roles for Cyo in @entity3 , in which it is the preferred oxidase for growth in acidic and low @entity1 conditions.

title: The @entity2 oxidase encoded by cyoABCD in XXXX is regulated by ActSR and is crucial for growth at low pH or low @entity1 conditions.

answer: @entity3


abstract: OBJECTIVES: Endoscopic surveillance of @entity0 with columnar-lined oesophagus (CLO) may identify those with @entity3 (AC). The benefits of surveillance are unproven and there is little evidence to support recommendations for precise endoscopic intervals. We sought to examine surveillance practice for CLO in the UK and the impact of endoscopic intervals on detection of @entity1 . METHODS: Eight hundred and seventeen @entity0 with CLO, registered with the UK National Barrett's Oesophagus registry and undergoing surveillance were studied. Endoscopic intervals were calculated and frequency of detection of @entity1 analysed using chi2 test of association. Factors affecting surveillance intervals were analysed using multiple linear regression. RESULTS: 94.7% of @entity0 with @entity2 ( @entity2 ), 95.0% with @entity6 ( @entity6 ) and 71.4% with AC were diagnosed on surveillance endoscopies. Mean endoscopic surveillance intervals varied between the centres from 1.07 to 1.63 years for nondysplastic @entity7 ; 0.69-1.19 years for @entity2 , and 0.35-1.17 years for @entity6 ; with overall mean surveillance intervals of 1.29, 1.01 and 0.44 years, respectively. When @entity2 was surveyed, significantly higher proportions of @entity6 /AC were detected at intervals of 3 months or less (P=0.013). Shorter endoscopic intervals were significantly associated with the presence of oesophageal strictures (P=0.002), @entity4 (P=0.046), increasing @entity0 age (P<0.001) and higher grade of @entity5 surveyed (P<0.001). CONCLUSION: A variation in surveillance practice for CLO was observed throughout the UK. A large proportion of @entity1 is detected on specific surveillance endoscopies. Shorter endoscopic intervals for surveillance of @entity2 are associated with an increased detection of @entity6 /AC.

title: Surveillance of Barrett's columnar-lined oesophagus in the UK: endoscopic intervals and frequency of detection of XXXX .

answer: @entity5


abstract: @entity3 are increasingly used to risk stratify adults with @entity2 . Published data describing the age-specific incidence of @entity3 and their prognostic relevance are largely derived from clinical trials. Trials frequently have age restrictions and low recruitment rates. Thus we investigated these factors in a population-based cohort of 349 @entity0 diagnosed during the course of 19 years in the northern part of England. The incidence of most @entity3 varied significantly with age. The incidence of t(9;22)(q34;q11) increased in each successive decade, up to 24% among 40- to 49-year-old subjects. Thereafter the incidence reached a plateau. t(4;11)(q21;q23) and t(1;19)(q23;p13) were a rare occurrence among @entity0 older than 60 years of age. In contrast, the frequency of t(8;14)(q24;q32) and t(14;18)(q32;q21) increased with age. High hyperdiploidy occurred in 13% of @entity0 younger than 20 years of age but in only 5% of older @entity0 . The incidence of @entity1 /near-triploidy and complex karyotype increased with age from 4% (15-29 years) to 16% (>or= 60 years). Overall survival varied significantly by age and cytogenetics. Older @entity0 and those with t(9;22), t(4;11), @entity1 /near-triploidy, or complex karyotype had a significantly inferior outcome. These population-based results demonstrate the cytogenetic heterogeneity of adult @entity2 . These data will inform the delivery of routine clinical services and the design of new age-focused clinical trials.

title: A population-based cytogenetic study of adults with XXXX .

answer: @entity2


abstract: BACKGROUND: The @entity0 microenvironment plays in an important role in the progression of @entity0 by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellular proliferation and tumorigenesis. Exposure to environmental toxicants, such as inorganic @entity3 (iAs), has also been implicated in the progression of @entity1 . OBJECTIVE: The role of iAs exposure on stromal signaling in the @entity0 microenvironment largely has been unexplored. Our objective was to elucidate molecular mechanisms of iAs-induced changes to stromal signaling by an enriched @entity1 microenvironment cell population, adipose-derived mesenchymal stem/stromal cells (ASC). RESULTS: ASC conditioned media (CM) collected after one week of iAs exposure @entity1 cell viability compared to ASC CM which received no iAs exposure. Cytokine array analysis suggested changes to cytokine signaling associated with iAs exposure. Subsequent proteomic analysis suggested a concentration-dependent alteration to the @entity5 / @entity4 / @entity2 signaling pathway by iAs. These results were validated by quantitative RT-PCR and Western blot, confirming a concentration-dependent increase in @entity5 and decrease in @entity4 expression in ASC following iAs exposure. Subsequently, utilizing a @entity2 pathway reporter construct we confirmed a decrease in stromal @entity2 signaling in ASC following iAs exposure. CONCLUSIONS: Our results suggest a concentration-dependent alteration of stromal signaling, specifically attenuation of stromal-mediated @entity2 signaling following exposure to iAs. Our results indicate iAs may enhance @entity1 cell viability through a previously unreported stromal-based mechanism. These findings illustrate that the stroma may mediate the effects of iAs in @entity0 progression, which may have future therapeutic implications.

title: Inorganic @entity3 Related Changes in the XXXX Microenvironment in a @entity1 Cell-Conditioned Media Model.

answer: @entity0


abstract: BACKGROUND: A significantly increased rate of positive preinterventional @entity6 histories in the unruptured @entity8 collective was demonstrated previously. The current study was designed to analyze the influence of the preinterventional @entity6 status on the outcome after treatment of unruptured @entity7 . METHODS: @entity0 treated due to @entity9 World Health Organization   I and unruptured @entity7 in 2 German neurosurgical centers between 2007 and 2013 were screened for exclusion criteria including @entity5 , recurrence of the @entity1 / @entity8 , and @entity4 among others. The preinterventional @entity6 histories and the rates of postinterventional @entity2 , @entity3 , symptoms of @entity10 , and quality of life (QOL) were determined by questionnaires that were mailed to the @entity0 in a printed version. RESULTS: A total of 58 M @entity0 and 45 iA @entity0 who met the inclusion criteria returned the questionnaires; 10 M (17.2%) and 17 iA @entity0 (37.8%) had a positive @entity6 history. The overall Incidental @entity8 collective demonstrated significantly lower overall QOL scores (P = 0.003) and significant greater rates of @entity10 (P = 0.009) compared with the M collective. After we excluded all @entity0 with positive pre-interventional @entity6 histories, those differences were no longer reproducible. Subjectively, the @entity0 did not realize any significant changes in their QOL after successful @entity8 treatment. CONCLUSIONS: The results of the current study demonstrate the importance of taking the preinterventional @entity6 history into considerations when evaluating the outcome after unruptured @entity8 treatment. The unfavorable outcome of the @entity8 group seems to be caused by factors that are not related the @entity8 diagnosis or treatment itself.

title: The Preinterventional Psychiatric History as a Major Predictor for a Reduced Quality of Life After Treatment of Unruptured XXXX .

answer: @entity7


abstract: Oral tolerance is the mechanism by which the immune system remains unresponsive to orally administered soluble antigens. @entity1 immunized with @entity0 TG (hTG), resulting in the induction of experimental @entity3 (EAT), provide an ideal in vivo system in which to examine oral tolerance to hTG. In the present study, we characterize epitopes of hTG that are capable of inducing oral tolerance. hTG is a large homodimeric protein, 660 Kd. The limited proteolysis of hTG using trypsin (TR) generates several smaller fragments of hTG ranging in size from 29 Kd to 145 Kd. Using hTG fragments h1TR (residues 1-521), h4bisTR (residues 2513-2713), h6TR (residues 522-1626), and h7TR (residues 1627-2512), prepared from both @entity2 rich and @entity2 poor hTG, we investigated the ability of these fragments to induce oral tolerance. The oral administration of @entity2 rich h6TR or h7TR suppresses hTG specific immune responses in a manner similar to whole hTG. In contrast, the oral administration of @entity2 rich h1TR or h4bisTR exacerbates hTG specific immune responses. Unlike @entity2 rich h1TR or h4bisTR, the oral administration of @entity2 poor h1TR or h4bisTR fails to augment hTG specific immune responses. In fact, h4bisTR suppresses hTG specific immune responses. These results indicate that hTG contains multiple epitopes that differentially affect oral tolerization. Tolerogenic epitopes reside within fragments h6TR and h7TR. The removal of @entity2 , and presumably hormone, from h4bisTR converts an immunogenic epitope to a tolerogenic epitope.

title: Multiple fragments of @entity0 TG are capable of inducing oral tolerance to whole XXXX TG.

answer: @entity0


abstract: AIM OF THE STUDY: A retrospective analysis of @entity7 in @entity0 with @entity4 consulted in the @entity0 's University Hospital of Krakow in the period 2007-2010. MATERIAL AND METHODS: The analysis included 60 @entity0 (33 @entity0 , and 27 @entity0 ) aged 1.2-32 years, mean 11.6 years. The @entity0 were followed up by many health care professionals: neurologists (EEG), neurosurgeons (CT, MRI), ophthalmologists, psychologists, ENT specialists, anthropologists (the assessment of body height and weight), geneticists, endocrinologists and gynecologists (the assessment of puberty according to Tanner scale, diagnostics of @entity3 , precocious puberty), and cardiologists (echo-cardiography). RESULTS: In the analyzed group of 60 @entity0 , 46 were consulted by geneticists, 20 by endocrinologists, 19 by neurologists and cardiologists. The imaging of the central nervous system (CNS) was performed in 37 @entity0 . Twenty-two @entity0 presented with familial @entity9 , 13 with sporadic @entity9 , and in 25 @entity0 , the family history was unavailable. @entity3 were present in 27.7% of @entity0 (13/47) that were referred to the anthropometric assessment. @entity3 (height < or = (-) 2 SD) was recognized in 9/47 of @entity0 (19.1%). Tall stature (> (+) 2 SD) was recognized in 4/47 of @entity0 (8.5%). All of the @entity0 with tall stature presented with central precocious puberty ( @entity6 ). Precocious puberty was also recognized in two @entity0 with normal stature. In all cases of @entity6 , @entity8 were recognized. Generally, organic CSN disorders were detected in 24 @entity0 (63.2%). MRI revealed @entity8 in 8 @entity0 , 4 presented with @entity1 of one or two optic nerves, 10 presented with hyperintensive areas on T2-weighted images, without enhancement after contrast injection, that may suggest the diagnosis of @entity2 , and 2 with @entity5 . CONCLUSIONS: 1. The most common disorders of the somatic development revealed in @entity9 @entity0 are @entity3 : @entity3 and tall stature caused by central precocious puberty. 2. In view of the incidence of @entity7 in @entity0 with @entity9 , the authors suggest an endocrine consultation in each case of @entity9 .

title: [ XXXX --the pediatric endocrinologist's point of view].

answer: @entity4


abstract: INTRODUCTION: Conventional radiologic modalities provide details only about the anatomic aspect of the various structures of the spine. Frequently the structures that show abnormal morphology may not be the cause of @entity4 ( @entity4 ). Functional imaging in the form of bone scan along with single photon emission computerized tomography (SPECT/CT) may be helpful in identifying structures causing @entity1 , whether morphologically normal or not. The objective of this study is to evaluate the role of bone scan with SPECT/CT in management of @entity0 with @entity4 . METHODS: This is randomized double-blinded controlled study performed on 80 @entity0 with @entity4 aged 20 to 80 years, ASA physical status I to III. @entity0 were randomized into bone scan and control groups consisting of 40 @entity0 each. On the basis of the clinical features and radiologic findings a clinical diagnosis was made. After making a clinical diagnosis, the @entity0 in bone scan group were subjected to bone scan with SPECT/CT. On the basis of the finding of the bone scan and SPECT/CT, a new working diagnosis was made and intervention was performed according to the new working diagnosis. @entity2 in the control group were given based on clinical diagnosis. Controlled comparative diagnostic blocks were performed with local anesthetic. The @entity1 score just after the diagnostic block and at the time of discharge (approximately 4 h later) was recorded; the @entity1 relief was recorded in percentage. RESULTS: In both the groups, sacroilitis was the most common diagnosis followed by facet joint @entity7 . The number of @entity0 obtaining @entity1 relief of >50% was significantly higher in the bone scan-positive group as compared with the control group. Three new clinical conditions were identified in the bone scan group. These conditions were @entity3 , @entity6 of the @entity8 , and @entity5 . CONCLUSIONS: Bone scan with SPECT/CT was found to complement the clinical workup of @entity0 with @entity4 . Inclusion of bone scan with SPECT/CT in @entity4 management protocol can help in making a correct diagnosis. At times it might bring out some new information that may be vital for further management of the @entity0 with @entity4 .

title: Evaluation of Efficacy of Bone Scan With SPECT/CT in the Management of Low Back XXXX : A Study Supported by Differential Diagnostic Local Anesthetic Blocks.

answer: @entity1


abstract: OBJECTIVES: To investigate the role of Cryptococcus in the immune system of immunocompetent @entity0 with @entity1 ( @entity1 ) by analysing the dynamic changes of @entity0 ' immune status before and after antifungal therapy. METHODS: The level of the serum @entity2 ( @entity2 ) and @entity5 was measured before and after 6-months of treatment. Peripheral blood samples were obtained from 30 immunocompetent @entity1 @entity0 and 30 age- and gender-matched healthy controls. Peripheral blood mononuclear cells (PBMCs) were isolated and incubated with recombinant @entity0 IL-12 (rhIL-12) for 48 h. Then the concentrations of @entity2 and @entity4 in the supernatant were analysed. RESULTS: Baseline serum @entity2 level was significantly lower in the @entity1 @entity0 as compared with the control group (P < 0.001). The serum @entity3 and @entity2 of @entity1 @entity0 were significantly increased after appropriate treatments (P < 0.05 and P < 0.001 when compared to their baseline levels). The productions of @entity2 in the culture supernatant of PBMCs showed no significant difference between the control and @entity1 @entity0 both before and after antifungal treatments. RhIL-12 is a potent stimulus for @entity2 production. Culture PBMCs collected from @entity1 @entity0 before treatments had a smaller increase of @entity2 production in the present of rhIL-12 than the control (P < 0.01); PBMCs from @entity1 @entity0 completing 6-months of treatment showed a comparable increase of @entity2 production by rhIL-12 stimulation to the control group. CONCLUSIONS: In apparently immunocompetent @entity0 with @entity1 , a normalization of serum @entity2 was achieved after recovery from infection. This suggests that Cryptococcus infection per se can suppress the immune system and its elimination contributes to the reestablishment of an immune equilibrium.

title: The Role of Cryptococcus in the Immune System of XXXX @entity0 .

answer: @entity1


abstract: BACKGROUND @entity1 is one of the most common problems in @entity0 with @entity5 , leading to increased morbidity and mortality. Effective management for @entity1 is based mainly on surgical and medical techniques with hyperosmolar therapy as one of the core medical treatments. The study aimed to explore the effects of continuous micro-pump infusions of 3% hypertonic saline combined with @entity4 on intracranial pressure control. MATERIAL AND METHODS We analyzed data on 56 eligible @entity0 with intracranial pressure >20 mmHg from March 2013 to July 2014. The target was to increase and maintain plasma @entity3 to a level between 145 and 155 mmol/L and osmolarity to a level of 310 to 320 mOsmol/kg. RESULTS Plasma @entity3 levels significantly increased from 138  5 mmol/L at admission to 151  3 mmol/L at 24 h (P<0.01). Osmolarity increased from 282  11 mOsmol/kg at baseline to 311  8 mOsmol/kg at 24 h (P<0.01). Intracranial pressure significantly decreased from 32  7 mmHg to 15  6 mmHg at 24 h (P<0.01). There was a significant improvement in CPP (P<0.01). Moreover, central venous pressure, mean arterial pressure, and Glasgow @entity2 Scale slightly increased. However, these changes were not statistically significant. CONCLUSIONS Continuous infusion of 3% hypertonic saline + @entity4 is effective and safe for intracranial pressure control.

title: Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with @entity4 to Control XXXX .

answer: @entity1


abstract: Tumor relapse after therapy typifies @entity1 ( @entity1 ) and is believed to be attributable to @entity0 stem cells (CSCs) that survive treatment. We have previously identified a CSC population derived from @entity1 that is characterized by @entity2 . Despite our growing knowledge of the importance of this subset of cells in driving @entity1 , the regulatory mechanism of @entity2 is not known. Epigenetic changes are believed to be essential in the control of @entity0 and stem cells. Here, we report the epigenetic regulation of @entity2 by miR-142-3p. The interaction between @entity2 and miR-142-3p was identified by in silico prediction and substantiated by luciferase reporter analysis. Expression of @entity2 was found to be inversely correlated with miR-142-3p in @entity1 clinical samples as well as in cell lines. Importantly, lower miR-142-3p expression in @entity1 was significantly associated with worst survival. Functional studies with miR-142-3p stably transduced in @entity1 cells demonstrated a diminished ability to self-renew, initiate @entity0 growth, invade, migrate, induce angiogenesis and resist chemotherapy. Rescue experiments whereby @entity2 and miR-142-3p is simultaneously overexpressed compensated the deregulated ability of the cells to confer these features. Thus, miR-142-3p directly targets @entity2 to regulate its ability to confer @entity0 and stem cell-like features in @entity1 .

title: Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker XXXX .

answer: @entity2


abstract: OBJECTIVES: This study sought to evaluate differential effects of @entity6 ( @entity6 ) and subcutaneous fat and their effects on @entity3 ( @entity3 ) risk across body mass index (BMI) categories. BACKGROUND: The regional distribution of adipose tissue is an emerging risk factor for @entity2 , although serial changes in fat distribution have not been extensively investigated. @entity6 and its alterations over time may be a better marker for risk than BMI in normal weight and overweight or @entity1 individuals. METHODS: We studied 1,511 individuals in the MESA (Multi-Ethnic Study of @entity5 ) with adiposity assessment by computed tomography (CT). A total of 253 @entity0 without @entity3 at initial scan underwent repeat CT (median interval 3.3 years). We used discrete Cox regression with net reclassification to investigate whether baseline and changes in @entity6 area are associated with @entity3 . RESULTS: Higher @entity6 was associated with cardiometabolic risk and @entity4 , regardless of BMI. After adjustment, @entity6 was more strongly associated with incident @entity3 than subcutaneous fat regardless of weight, with a 28% greater @entity3 hazard per 100 cm(2)/m @entity6 area and significant net reclassification (net reclassification index: 0.44, 95% confidence interval [CI]: 0.29 to 0.60) over clinical risk. In individuals with serial imaging, initial @entity6 (hazard ratio: 1.24 per 100 cm(2)/m, 95% CI: 1.08 to 1.44 per 100 cm(2)/m, p  = 0.003) and change in @entity6 (hazard ratio: 1.05 per 5% change, 95% CI: 1.01 to 1.08 per 5% change, p  = 0.02) were associated with @entity3 after adjustment. Changes in subcutaneous fat were not associated with incident @entity3 after adjustment for clinical risk and @entity6 area. CONCLUSIONS: @entity6 is modestly associated with BMI. However, across BMI, a single measure of and longitudinal change in @entity6 predict @entity3 , even accounting for weight changes. Visceral adiposity is essential to assessing cardiometabolic risk, regardless of age, race, or BMI, and may serve as a marker and target of therapy in @entity2 .

title: Visceral Adiposity and the Risk of XXXX Across Body  Mass  Index: The MESA Study.

answer: @entity3


abstract: Ten individuals developed an @entity1 -like illness after a single exposure to high levels of an irritating vapor, fume, or smoke. In most instances, the high level exposure was the result of an accident occurring in the workplace or a situation where there was poor ventilation and limited air exchange in the area. In all cases, symptoms developed within a few hours and often minutes after exposure. We have designated the illness as @entity0 ( @entity0 ) because a consistent physiologic accompaniment was airways hyperreactivity. When tested, all subjects showed positive @entity5 challenge tests. No documented preexisting @entity4 was identified nor did subjects relate past @entity4 . In two subjects, atopy was documented, but in all others, no evidence of @entity2 was identified. In the majority of the cases, there was persistence of respiratory symptoms and continuation of airways hyperreactivity for more than one year and often several years after the incident. The incriminated etiologic agent varied, but all shared a common characteristic of being irritant in nature. In two cases, bronchial biopsy specimens were available, and an airways inflammatory response was noted. This investigation suggests acute high level, uncontrolled irritant exposures may cause an @entity1 in some individuals which is different from typical @entity6 . It can lead to long-term sequelae and @entity3 . Nonimmunologic mechanisms seem operative in the pathogenesis of this syndrome.

title: Reactive @entity0 ( @entity0 ). XXXX after high level irritant exposures.

answer: @entity1


abstract: Oxidized low-density lipoproteins (oxLDL) exhibit proinflammatory properties and play a role in @entity5 plaque formation, @entity3 , and subsequent @entity4 . OxLDL alter the activity of the transcription factor NF-kappaB that is involved in the expression of immune and inflammatory genes. In contrast, high-density lipoproteins (HDL) are anti-atherogenic and exhibit anti-inflammatory properties. This work aimed to investigate how oxLDL activate NF-kappaB and whether and how HDL may prevent NF-kappaB activation. In cultured @entity1 smooth muscle cells, mitogenic concentrations of mildly oxLDL trigger a rapid and transient NF-kappaB activation, which is strongly inhibited by HDL. Growth factors, @entity7 3-kinase/Akt, and @entity8 kinase pathways are not implicated in the oxLDL-induced NF-kappaB activation and are not targets of HDL. OxLDL induce reactive @entity0 species (ROS) generation and proteasome activation, which are implicated in NF-kappaB activation, as suggested by the inhibitory effect of the antioxidants @entity6 and @entity9 and the proteasome inhibitor PSI. HDL were able to prevent the intracellular ROS rise triggered by oxLDL or @entity2 , thereby inhibiting the subsequent proteasome activation, IkappaB degradation, and NF-kappaB activation. In conclusion, the oxLDL-induced NF-kappaB activation involves ROS generation and proteasome activation, both events being inhibited by HDL. This 'antioxidant' and potentially anti-inflammatory effect of HDL may participate in their general anti-atherogenic properties.

title: HDL counterbalance the proinflammatory effect of oxidized LDL by inhibiting intracellular reactive XXXX species rise, proteasome activation, and subsequent NF-kappaB activation in smooth muscle cells.

answer: @entity0


abstract: UNASSIGNED: High throughput screens allow us to understand how transcription factors trigger developmental processes including cell specification. A major challenge is the identification of their binding sites because feedback loops and homeostatic interactions may mask the direct impact of those factors in transcriptome analyses. Moreover, this approach dissects the downstream signaling cascades and facilitates the identification of conserved transcriptional programs. Here we show the results and the validation of a DamID genome-wide screen that identifies the direct targets of Glide/Gcm, a potent transcription factor that controls glia, hemocyte and tendon cell differentiation in @entity1 . The screen identifies many genes that had not been previously associated to Glide/Gcm and highlights three major signaling pathways interacting with Glide/Gcm: @entity2 , @entity3 and @entity4 / @entity5 , which all involve feedback loops. Furthermore, the screen identifies effector molecules that are necessary for cell-cell interactions during late developmental processes and/or in ontogeny. Typically, Immunoglobulin domain-containing (or Ig-domain-containing) proteins control cell adhesion and axonal navigation (PATEL AND VAN VACTOR 2002). This shows that early and transiently expressed fate determinants not only control other transcription factors that in turn implement a specific developmental program but also directly affect late developmental events and cell function. Finally, while the @entity0 genome contains two orthologous Gcm genes, their function has been demonstrated in vertebrate-specific tissues, placenta and parathyroid glands, begging questions on the evolutionary conservation of the Gcm cascade in higher organisms. Here we provide the first evidence for the conservation of Gcm direct targets in @entity0 . In sum, this work uncovers novel aspects of cell-specification and sets the bases for further understanding of the role of conserved Gcm gene regulatory cascades.

title: Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte and Tendon Cell Differentiation in XXXX .

answer: @entity1


abstract: This article contributes to the research on demographics and public health of urban populations of preindustrial Europe. The key source is a burial register that contains information on the deceased, such as age and sex, residence and cause of @entity2 . This register is one of the earliest compilations of data sets of individuals with this high degree of @entity7 and consistency. Critical assessment of the register's origin, formation and upkeep promises high validity and reliability. Between 1805 and 1815, 4,390 deceased inhabitants were registered. Information concerning these individuals provides the basis for this study. Life tables of Bern's population were created using different models. The causes of @entity2 were classified and their frequency calculated. Furthermore, the susceptibility of age groups to certain causes of @entity2 was established. Special attention was given to causes of @entity2 and mortality of newborns, @entity0 and birth-giving @entity0 . In comparison to other cities and regions in Central Europe, Bern's mortality structure shows low rates for @entity0 (q0=0.144) and @entity0 (q1-4=0.068). This could have simply indicated better living conditions. Life expectancy at birth was 43 years. Mortality was high in winter and spring, and decreased in summer to a low level with a short rise in August. The study of the causes of @entity2 was inhibited by difficulties in translating early 19th century nomenclature into the modern medical system. Nonetheless, @entity2 from @entity3 , illnesses of the respiratory system, and debilitation were the most prominent causes in Bern. Apparently, the worst killer of @entity0 up to 12 months was the "gichteren", an obsolete German term for lethal spasmodic @entity6 . The exact modern identification of this disease remains unclear. Possibilities such as @entity0 @entity1 or @entity0 @entity5 are discussed. The maternal @entity2 rate of 0.72% is comparable with values calculated from contemporaneous sources. Relevance of childbed @entity4 in the early 1800s was low. Bern's data indicate that the extent of deaths related to childbirth in this period is overrated. This research has an explicit interdisciplinary value for various fields including both the humanities and natural sciences, since information reported here represents the complete age and sex structure of a deceased population. Physical anthropologists can use these data as a true reference group for their palaeodemographic studies of preindustrial Central Europe of the late 18th and early 19th century. It is a call to both historians and anthropologists to use our resources to a better effect through combination of methods and exchange of knowledge.

title: Mortality and morbidity in the city of Bern, Switzerland, 1805-1815 with special emphasis on XXXX , @entity0 and maternal deaths.

answer: @entity0


abstract: Biventricular pacing ( @entity2 ) is emerging for @entity0 with @entity1 ( @entity1 ) and asynchrony. We measured basal asynchrony and early resynchronization by radionuclide angioscintigraphy (RNA) in order to predict long-term evolution of ventricular function after @entity2 . Thirty-four @entity0 (NYHA Class III-IV,65.4 +/- 11 years) with large QRS(179 +/- 18 ms)were implanted with @entity2 and studied by RNA before (D0), at day 8 (D8), and during follow-up(20 +/- 7 months). We calculated left and right ejection fractions, the @entity3 (TRVLV), and the apicobasal dyssynchrony (Tab). LVEF improved from 20.2 +/- 8.1%(D0) to27.1%+/- 12.6%(follow-up,P < 0.003 vs D0) and RVEF from 28.6%+/- 13%(D0) to 34.3 +/- 11.5%(follow-up,P < 0.03 vs D0). Inter- (DeltaTRVLV) and intraventricular resynchronization was immediate and remained stable: TRVLV decreased from 68.3 +/- 38 ms(D0) to 13.4 +/- 48.5 ms(D8) and1.8 +/- 39.2 ms(follow-up,P < 0.0001 vs D0); and Tab from 45.8 +/- 64.1 msto-18 +/- 68(D8) and-28.3 +/- 53.6 ms(follow-up,P < 0.0001 vs D0). Early inter- and intraventricular resynchronization (DeltaTab) at D8 were related to late LVEF and RVEF improvement. Together, an LVEF > 15% and a significant @entity3 (TRVLV > 60 ms) at D0 have a sensitivity of 79% and a positive predictive value of 83% to predict an improvement of LVEF superior to 5% at follow-up. In @entity1 @entity0 , @entity2 resynchronizes ventricles early and in the long-term, while RVEF and LVEF improve progressively. @entity0 with large electromechanical dyssynchrony benefit most from @entity2 .

title: Basal asynchrony and resynchronization with biventricular pacing predict long-term improvement of LV function in heart failure XXXX .

answer: @entity0


abstract: Hospital discharges and @entity1 attributed to chronic @entity5 and @entity4 have fallen in recent years while the number of those receiving invalidity benefit for these conditions has remained constant. One hundred and fifty seven such @entity0 were invited to take part in this study, in which the diagnosis, degree of @entity3 , and other factors contributing to disability were reviewed. The scope for rehabilitation was considered. One hundred subjects agreed to take part; 96 were @entity0 and 70 were over 60 years. In only 67 was the main diagnosis chronic @entity5 and @entity4 . There was a bimodal distribution of functional impairment, most being severely disabled, but in 20 the FEV1 was within the normal range. Among these @entity2 was more common and psychological factors were important. Economic factors contributed to "invalidity," especially among those with a normal FEV1. For 32 of the 57 who had declined to take part some information was available from hospital records. The findings in this group were similar. There was little scope for rehabilitation in the group as a whole as motivation was poor. Less than half had ever seen a chest physician. Specialist assessment before invalidity benefit is claimed is probably desirable.

title: "Invalidity" due to chronic @entity5 and XXXX : how real is it?

answer: @entity4


abstract: Crude brain extract (100,000 g supernate from newborn or fetal @entity0 brain homogenate) was studied for its effects on the number and distribution of @entity1 receptors (AChRs) on myotubes of the L5 cloned myogenic cell line and compared to that of @entity0 primary cultures. Gamma counting, light autoradiography and scanning electron microscopic autoradiography were used. We found that the L5 cells responded to the brain extract with an increase in the average @entity2 site density (2-5-fold) and with an increase in @entity2 clustering. Clustering was manifested by both an increase in the number of @entity2 clusters and in the ratio of receptor site density within clusters relative to that between clusters. The increase in average @entity2 site density was shown to be due to an increase in the rate of @entity2 insertion into the surface membrane with little change in the rate of receptor degradation. As also previously reported, the @entity0 myotubes had a similar clustering response but only a very slight (approximately 1.2-fold) increase in average @entity2 site density. The surface area of myotubes was also increased slightly (approximately 1.2-1.3-fold) by the brain extract. Autoradiography viewed by scanning EM was found to be very useful in illustrating the shape and distribution of the receptor clusters. After the brain extract was fractionated on Sephadex G-200, the fractions with greatest clustering activity could be separated from those causing predominantly an increase in receptor site density. Increased receptor site density was primarily produced by the low molecular weight fractions (less than 12 kD), whereas the strongest (but not exclusive) effect on clustering was produced by the high molecular weight fractions (greater than 140 kD). Furthermore, the two cell types assayed had different sensitivity to the different factors. L5 cells responded to both the high and low molecular weight factors while @entity0 primary cells are sensitive primarily to the high molecular weight factors.

title: Differential responses of L5 and XXXX primary muscle cells to factors in @entity0 brain extract.

answer: @entity0


abstract: PURPOSE: To retrospectively review bilateral venograms free of @entity1 to evaluate the frequency and types of variations seen in venous anatomy. MATERIALS AND METHODS: A retrospective review of 404 bilateral (808 limbs) lower limb venograms obtained from medical @entity0 participating in a thromboprophylaxis clinical trial and found to be free of @entity1 was performed. Venograms were evaluated according to predetermined criteria for the presence of duplication of vessels and inter- and intraindividual variations in venous anatomy. Variations were assessed with analysis of variance and chi2 tests. RESULTS: Two vessels were seen in the popliteal fossa on 337 (42%) of 808 venograms, and 41 (5%) were true duplicated popliteal veins. There were 253 (31%) duplicated superficial femoral veins (SFVs), with 12 (1.5%) being complex duplicated systems. Of 265 duplicated SFVs, 138 (52%) began in the midthigh region and 80 (30%), in the adductor canal region. The duplicated vessel was medial to the main @entity3 in 122 (46%), lateral in 131 (49%), and both (ie, triplications) in 12 (4.5%). The length of the duplicated @entity3 ranged from 1 to 35 cm; 6-15 cm was the most common length in 162 (62%) SFVs. There was no significant association between the incidence of anatomic variations and age or sex (P >.1). The presence of multiple vessels in one leg was strongly correlated with the probability of occurrence in the other leg (P <.001). CONCLUSION: Variations in lower limb venous anatomy are common and have important implications for the US diagnosis of @entity2 .

title: Variations in lower limb venous anatomy: implications for US diagnosis of XXXX .

answer: @entity2


abstract: BACKGROUND: @entity6 , @entity3 and @entity5 are associated with increased risk of @entity4 . However, little is known about the underlying signaling events influencing risk. We aimed to investigate the relationship between these risk factors and @entity7 phosphorylation, to determine prognostic value. METHOD: VEGF-positive @entity4 biopsies, with known HPV status, were analyzed by immunohistochemistry (IHC) for @entity7 , phosphorylated at residues S473 and T308. Comparisons between the tissues were carried out using a Mann-Whitney U test. Associations between the variables and continuous immunohistochemical parameters were evaluated with general linear models. @entity0 characteristics and pAkt IHC score were analyzed for possible association with overall survival by Cox proportional hazard models. RESULTS: Immunohistochemistry revealed that @entity1 @entity0 had significantly higher levels of pAkt T308 than S473 (P   <   0.001). Smoking and @entity3 were found to be independent risk factors for @entity7 phosphorylation at T308 (P   =   0.022 and 0.027, respectively). @entity0 with @entity1 positive for HPV or pAkt S473 had a poorer prognosis (P   =   0.005, and 0.004, respectively). @entity0 who were heavy drinkers were 49 times more likely to die than non-drinkers (P   =   0.003). @entity0 with low pAkt T308 were more likely to be HPV positive (P   =   0.028). Non-drinkers were also found to have lower levels of pAkt T308 and were more likely to have @entity1 positive for HPV than heavy drinkers (P   =   0.044 and 0.007, respectively). CONCLUSION: This study suggests different mechanisms of @entity2 are initiated by smoking, @entity3 and HPV. Our data propose higher phosphorylation of @entity7 at T308 as a reliable biomarker for smoking and @entity3 induced @entity4 progression and higher phosphorylation of @entity7 at S473 as a prognostic factor for @entity4 .

title: Activation of @entity7 at T308 and S473 in @entity3 , @entity6 and HPV-induced XXXX : is there evidence to support a prognostic or diagnostic role?

answer: @entity4


abstract: The authors present results of treatment of 128 @entity0 aged 32-75 with great @entity2 using the method of autodermal immersion graft hernioplasty. Hernias most often appeared after low median laparotomies. Planned operations were performed in 94.6% of cases, in 5.4% plasty was carried out in @entity0 with @entity1 without pyo-inflammatory alterations in the @entity1 sac. The implant was treated by the V.N. Yanov method. The postoperative period was mainly favorable, without lethal outcomes. Suppuration of the wounds took place in 2.3% of cases. Long-term results were followed-up in 80.5% of the @entity0 (during the periods 6 months--11 years). Recurrent @entity1 were found in 3.1%. The other @entity0 had good results of operations.

title: [Dermal autograft immersion plasty by a flap method for large postoperative XXXX of the abdomen].

answer: @entity1


abstract: @entity2 exposure in vivo can reduce the material strength of bone, an effect that has been attributed to a change in mineral structure. An in vitro model of @entity2 exposure offers the potential to study directly the effects of @entity2 on bone mineral. Previous investigators have reported that soaking bones in @entity4 in vitro reduces bone strength. However, long soaking times and the absence of physiological buffering ions from their treatment solutions may have caused mineral dissolution that contributed to the decrease in bone strength. Our objectives were to further characterize the effects of in vitro @entity2 exposure on bone mechanical properties and to determine if the changes reported in previous studies of @entity1 cortical bone would be observed for whole rodent bones. We soaked 60 @entity0 femora in @entity4 solutions, with and without physiological buffering ions, and evaluated their torsional and bending properties. @entity2 soaked bones had a 30-fold increase in @entity2 content and a 23% increase in water content compared to controls. These changes were associated with average reductions in ultimate load of 45%, reductions in @entity3 of 70%, and increases in deformation to failure of 80%. The effect of @entity2 was similar for bones treated in buffered and non-buffered solutions, and was observed in both torsion and bending. Our findings confirm those of previous studies and highlight the strong effect that in vitro @entity2 exposure has on bone mechanical properties. The in vitro model of @entity2 exposure offers a tool to further study the effects of ion substitution in bone.

title: In vitro XXXX exposure decreases torsional and bending strength and increases ductility of @entity0 femora.

answer: @entity4


abstract: UNASSIGNED: Purpose. To evaluate the relationships among the optic nerve head (ONH) area, macular ganglion cell complex (mGCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and @entity1 in @entity0 with @entity2 ( @entity2 ). Methods. This retrospective study included 90 eyes of 90 @entity0 with @entity2 . The ONH area, rim area, mGCC thickness, and cpRNFL thickness were measured using optical coherence tomography. @entity3 ( @entity3 ) was measured using standard automated perimetry. The relationships among clinical factors including age, refraction, the ONH area, the rim area, the mGCC thickness, the cpRNFL thickness, and @entity3 were evaluated using correlation coefficients and multiple regression analyses. Results. The significant correlation of the ONH area with refraction (r = 0.362, P < 0.001), the mGCC thickness (r = 0.225, P = 0.033), and the cpRNFL thickness (r = 0.253, P = 0.016) was found. Multiple regression analysis showed that the ONH area, rim area, and @entity3 were selected as significant contributing factors to explain the mGCC thickness and cpRNFL thickness. No factor was selected to explain @entity3 . Conclusions. The ONH area, in other words, the disc size itself may affect the mGCC thickness and cpRNFL thickness in @entity2 @entity0 .

title: Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in XXXX with @entity2 .

answer: @entity0


abstract: OBJECTIVE: We conducted a randomized, double-blinded, placebo-controlled trial to investigate the efficacy of @entity4 536 (BB536) supplementation for induction of remission in Japanese @entity0 with active @entity1 ( @entity1 ). METHODS: Fifty-six @entity0 with mild to moderate @entity1 were enrolled. Eight @entity0 had pancolitis, 31 had left-sided @entity2 , and 17 had @entity3 . @entity0 were randomly treated with 2-3   *   10(11) freeze-dried viable BB536 (28 @entity0 ) or placebo (28 @entity0 ) for 8   weeks. RESULTS: In total, 63% of @entity0 receiving BB536 showed clinical remission ( @entity1 disease activity index [UCDAI]    <=   2) at week 8 compared to 52% of those receiving placebo (P   =   0.395). We observed a significant decrease of UCDAI scores (3.5        1.9 at baseline to 2.5        1.7 at week 8) in the BB536 group (P   <   0.01), while there was no significant decrease in the placebo group (P   =   0.88). There was also a significant decrease in the Rachmilewitz endoscopic index (EI) and the Mayo sub-score at week 8 in the BB536 group, while there was no significant decrease in the placebo group. Besides the single @entity0 in the BB536 group who complained of a mild side effect, no other adverse effects were observed. CONCLUSIONS: Supplementation with BB536 was well tolerated and reduced UCDAI scores, EI and Mayo sub-scores after 8   weeks in Japanese @entity0 with mild to moderately active @entity1 . This article is protected by copyright. All rights reserved.

title: Efficacy of probiotic treatment with @entity4 536 for induction of remission in active XXXX : A randomized, double-blinded, placebo-controlled multicenter trial.

answer: @entity1


abstract: OBJECTIVES: To investigate the association between random measured @entity6 levels in middle and old age and @entity5 -related @entity4 . DESIGN: Population-based cohort study. SETTING: Norwegian Counties Study (middle-aged individuals; 35-49) and Cohort of Norway @entity0 (older individuals; 65-80). @entity0 : Individuals without (n  =  74,630) and with (n  =  3,095) known @entity1 (N  =  77,725); 67,865 without and 2,341 with @entity1 were included in the complete case analyses (nonmissing for all included covariates), of whom 1,580 without and 131 with @entity1 died from @entity5 -related causes. MEASUREMENTS: @entity4 was ascertained according to the Norwegian Cause of Death Registry. Cox regression was used to assess the relationship between random @entity6 levels (nonfasting) in individuals without and with @entity1 and @entity5 -related @entity4 . Education, smoking, @entity2 , body mass index, @entity3 , blood pressure, and physical activity were adjusted for. RESULTS: Individuals without @entity1 at midlife with @entity6 levels between 6.5 and 11.0  mmol/L had a significantly greater risk of @entity5 -related @entity4 than those with levels less than 5.1  mmol/L (hazard ratio  =  1.32, 95% confidence interval  =  1.04-1.67) in a fully adjusted model. A dose-response relationship (P  =  .02) was observed. No significant association between high @entity6 levels in individuals aged 65 to 80 and @entity5 -related @entity4 was detected. CONCLUSION: High random @entity6 levels measured in middle-aged but not older age @entity0 without known @entity1 were associated with greater risk of @entity5 -related @entity4 up to four decades later.

title: Association Between Random Measured XXXX Levels in Middle and Old Age and Risk of @entity4 .

answer: @entity6


abstract: Suicide is one of the major causes of preventable @entity4 . We evaluated suicidality among pregnant @entity0 who participated in prenatal care in Brazil. A total of 255 @entity0 were assessed using semi-structured interviews as well as the Edinburgh Postnatal @entity5 Scale (EPDS), Beck @entity5 Inventory (BDI), and Mini-International @entity1 Interview (MINI) Plus. Thereafter, Stata 12 was used to identify the significant predictors of current suicide risk (CSR) among @entity0 using univariate and multivariate analyses (p   <   0.05). According to MINI Plus module C, the lifetime suicide attempt rate was 12.55  %. The overall CSR was 23.53  %, distributed across risk levels of low (12.55  %), moderate (1.18  %), and high (9.80  %). Our rates approximate those found in another Brazilian study (18.4  %). @entity5 ( @entity5 ), lifetime @entity3 , and any current @entity2 (as measured using the MINI) as well as BDI scores >= 15 and EPDS scores >= 11 were identified as positive risk factors in a univariate analysis (p   <   0.001). These factors changed after a multivariate analysis was employed, and only years of education [odds ratio (OR)   =   0.45; 95  % confidence intervals (CIs)   =   0.21-0.99], @entity5 (OR   =   3.42; 95  % CIs   =   1.37-8.53), and EPDS scores >= 11 (OR   =   4.44; 95  % CIs   =   1.97-9.97) remained independent risk factors. @entity5 and other @entity1 were the primary risk factors for suicidality, although only the former remained an independent factor after a multivariate analysis. More than 10  years of education and EPDS scores >= 11 were also independent factors; the latter can be used as a screening tool for suicide risk.

title: Suicidality among pregnant XXXX in Brazil: prevalence and risk factors.

answer: @entity0


abstract: OBJECTIVE: To study effect of overexpression of @entity4 -inducible factor-1a induced by @entity5 in  vivo in LNCaP @entity0 on @entity0 growth rate. METHODS: The @entity3 LNCaP cells were inoculated in the abdomen of @entity1 . All the @entity1 were randomly placed in the gas chamber with different @entity2 content. The groups were divided as follows: twelve @entity1 in @entity4 group, sixteen @entity1 in normoxia group, ten @entity1 in @entity5 group. After 28  d of treatment, the @entity1 were weighed, the blood samples were taken from the left ventricle, and the @entity0 was isolated and weighed. @entity0 growth, @entity8 and vascularization, @entity7 expression and intracellular signal transduction molecules expression in each group of xenografts were detected and analyzed by using Western blotting and immunofluorescence and determination of hemoglobin. RESULTS: Comparison of the growth of xenografts in each group showed that, the xenografts growth of @entity4 group was more quickly than that of normoxia group. The difference was statistically significant (P  =  0.004). The difference in xenografts growth between @entity5 group compared and normoxia group was not statistically significant (P  >  0.05). The expressions of @entity7 , @entity6 and @entity6 -R of xenografts in @entity5 group were significantly higher than those of normoxia group (P  <  0.05). The expression of @entity7 of xenografts in @entity4 group and normoxia group were similar. The blood growth rate of xenografts in @entity4 group (170%) was significantly higher than that of normoxia group (40%) (P  <  0.05). The expression of @entity9 of xenografts in @entity5 group was significantly higher than that of normoxia group (P  <  0.05). CONCLUSIONS: When @entity5 induces the overexpression of @entity7 in LNCaP @entity0 , it will not affect @entity0 growth. It provides a new ideas and theoretical basis for the clinical treatment of @entity3 .

title: Effect of overexpression of @entity4 -inducible factor-1a induced by XXXX in  vivo in LNCaP @entity0 on @entity0 growth rate.

answer: @entity5


abstract: BACKGROUND: Pituitary abscess is a rare but potentially life-threatening condition with an incidence of 0.2-1.1% of operative @entity9 . Diagnosis can be challenging, as this disorder shares many similarities with other @entity9 in terms of symptomatology and radiographic findings. Most pituitary abscesses are categorized as secondary, arising from pre-existing @entity9 or in conjunction with transsphenoidal surgery, @entity3 , @entity4 , or @entity6 . To date, there have been only a handful of reports of primary @entity5 , which occurs without any of the aforementioned risk factors. CASE DESCRIPTION: We present a case of primary @entity5 in a 38-year-old @entity0 with @entity1 , @entity2 , @entity8 , and @entity11 who was found to have @entity10 . Brain magnetic resonance imaging demonstrated a sellar/suprasellar mass, which was endoscopically resected via a transsphenoidal approach. Egress of yellow-greenish creamy fluid was noted upon dural incision. The @entity0 was treated with a 6-week course of antibiotic therapy postoperatively and had resolution of symptoms. CONCLUSIONS: A PubMed search was performed; all cases of @entity5 reported in the literature were screened, and 200 cases including our case were analyzed with a focus on outcomes. The most common presentations were @entity1 , @entity2 . Approximately 66.1% of @entity0 achieved partial or complete recovery of pituitary function; 75.7% with vision deficits recovered visual function. Treatment via a craniotomy had a recurrence rate of 17.2% compared to 9.7% via a transsphenoidal approach. To our knowledge, this is the first systematic review on the topic and the largest series reported.; Abbreviations: DI, @entity7 , MR, magnetic resonance.

title: Case Report of a Primary Pituitary Abscess and Systematic Literature Review of Pituitary Abscess with a Focus on XXXX Outcomes.

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) stress induces social avoidance and @entity2 -like phenotypes. Amygdala is recognized as an emotion-related brain region such as fear, aversion and @entity2 . It is conceivable to hypothesize that activation of amygdala is involved in @entity3 -dependent @entity1 . RESULTS: @entity3 model was established using C57BL/6J @entity0 that were physically defeated by different CD-1 @entity0 for 10  days. Stressed @entity0 exhibited decreased social interaction level in social interaction test and significant @entity1 in elevated plus maze and open field tests. Meanwhile, a higher phosphorylation of PKA and @entity8 with a mutually linear correlation, and increased @entity7 labeled cells in the basolateral amygdala (BLA) were observed. Activation of PKA in the BLA by @entity4 , a PKA activitor, significantly upregulated pCREB and @entity7 expression. To address the role of PKA activation on @entity3 stress-induced social avoidance and @entity1 , @entity4 or @entity6 , a PKA inhibitor, was continuously administered into the bilateral BLA by a micro-osmotic pump system during the 10-day @entity3 period. Neither @entity6 nor @entity4 affected the social behavior. Differently, @entity4 significantly relieved @entity1 in both general and moderate @entity3 protocols. @entity6 per se did not have anxiogenic effect in na  ve @entity0 , but aggravated moderate @entity3 stress-induced @entity1 . The antidepressant @entity5 reduced @entity3 -induced @entity2 and up-regulated pPKA level in the BLA. CONCLUSIONS: These results suggest that @entity3 -driven PKA activation in the basolateral amygdala is actually a compensatory rather than pathogenic response in the homeostasis, and modulating amygdaloid PKA may exhibit potency in the therapy of social derived disorders.

title: Activation of protein kinase A in the amygdala modulates XXXX in social defeat exposed @entity0 .

answer: @entity1


abstract: INTRODUCTION: We report our experience with the superselective embolization of @entity3 . We used new coaxial catheters and new microcoils to assess their technical features and efficacy. MATERIALS AND METHODS: Diagnostic angiography by catheterization of the main renal artery was performed in 7 @entity0 with suspected @entity1 to detect injury presence and site. After super-selective catheterization of the feeding arteries with a coaxial catheter (Tracker 18), we performed embolization with @entity2 microcoils inserted using a coil pusher. The procedure efficacy was assessed at angiography and by comparing serum hemoglobin and hematocrit levels before and after embolization; posttreatment renal function was also studied. RESULTS: Selective embolization permitted complete occlusion of the arteries feeding the @entity3 in all @entity0 , preserving as much parenchyma as possible. Hemoglobin and hematocrit levels were improved or unchanged after the maneuver (average hemoglobin level before embolization: 9.01 mg/dl versus 9.95 mg/dl after embolization; average hematocrit level before embolization: 27.3% versus 30.06% after embolization). We had no difficulty during microcoil insertion and the coaxial catheter was always stable. CONCLUSION: Superselective embolization of @entity3 is an effective and definitive treatment. We recommend it in the @entity0 with @entity1 due to @entity3 after percutaneous diagnostic or therapeutic procedures.

title: [Embolization of XXXX with coaxial catheters and microcoils].

answer: @entity1