abstract: BACKGROUND: Major joints of the lower limbs are commonly affected by @entity3 ( @entity3 ), with consequent @entity2 , loss of function, and progressive disability. Knee replacement represents a useful solution, but a highly constrained implant design is often needed in order to face the severe anatomical @entity1 and the gross instability that the surgeon may encounter in the rheumatoid knee. OBJECTIVES: The aim of this work was to evaluate the @entity5 -Model(  ) rotating hinge knee prosthesis implanted in @entity0 affected by @entity3 and severely damaged knees. @entity0 AND METHODS: We retrospectively evaluated a series of 38  @entity0 with @entity3 implanted with the @entity5 -Model(  ) rotating hinge knee prosthesis for primary or revision surgery (mean follow-up 6.1  years; mean age at surgery 71.5  years). At the time of surgery, the mean duration of @entity3 was 13.2  years. @entity0 were evaluated clinically and radiographically and the Knee Society Score (KSS) was used. RESULTS: Implant survival at most recent follow-up was 91.7   %. Mean final knee flexion was 102.7     . The mean KSS was 93.5 (excellent) and 67.1 (good) for clinical and functional score, respectively. Mild @entity2 was present in 10  @entity0 . No sign of @entity4 or residual instability was found. No evidence of loosening or implant failure was observed in x-rays. CONCLUSION: The @entity5 -Model(  ) rotating hinge knee prosthesis provides excellent @entity2 relief, functional recovery, and intrinsic knee stability both in complex primary and in revision knee arthroplasty in the majority of @entity0 with severely affected @entity3 .

title: The XXXX -Model(  ) rotating hinge for @entity3 : Functional results in primary and revision surgery.

answer: @entity5


abstract: OBJECTIVE: To assess the feasibility of applying lung autotransplantation technique in the treatment of @entity1 of the @entity6 . METHODS: Two @entity0 underwent @entity7 upper and middle bilobectomy. Because the length of resected bronchus or pulmonary artery involved by @entity2 was too long to perform tension-free @entity3 , we had to transplant the lower lobar vein into the proximal stump of the upper lobar vein. Another two @entity0 underwent pneumonectomy firstly, because we could not perform sleeve lobectomy in suit as the @entity2 extended through the oblique fissure to the margin of the lower lobe. Subsequently, we resected the @entity2 parts at a separate table, and replanted the preservable part of the lung into the chest. RESULTS: Being followed up to December 1999, the @entity0 1, 3 and 4 had been alive with @entity2 free for 31, 18 and 13 months. The @entity0 1 and 3 had a good living quality but the @entity0 4 had a very poor activity. The @entity0 4 received resection of the replanted lung for pulmonary artery bronchus @entity5 on the 42nd day after operation. The second @entity0 died of tension pneumothorax associated with @entity4 on the 19th day after operation. CONCLUSION: Lung autotransplantation is an alternative technique for pulmonary preservation in @entity0 with @entity2 of the @entity6 whose cardiopulmonary function is too poor to undergo pneumonectomy.

title: Lung autotransplantation technique for treating XXXX of @entity6 .

answer: @entity1


abstract: OBJECTIVE: Ultrasound is a widespread noninvasive method of prenatal diagnosis. The detection of fetal abnormalities can provoke @entity1 , which needs coping. The coping process of pregnant @entity0 with different risk conditions for fetal abnormality were studied in a longitudinal design and compared with a nonrisk control group of @entity0 with healthy uncomplicated pregnancies. METHODS: The coping strategies of @entity0 (n=664) during the second trimester were assessed with a questionnaire [Heim E, Augustiny KF, Blaser A, Schaffner L. Berner Bew  ltigungsformen (BEFO) Handbuch. Bern: Huber, 1991]. Data were collected at three points in time: immediately before the ultrasound scanning for @entity2 , at 5-6 and 10-12 weeks after the prenatal ultrasound examination. Questionnaires were also used to collect information about sociodemographic data, @entity1 , pregnancy data and personality. RESULTS: The analysis of the coping strategies of @entity0 with high-risk pregnancies (n=497) and as well of these with no-risk conditions in the control group (n=167) revealed three different factors of coping: Factor I: positive emotional attitude/distance, Factor II: negative emotional attitude/disapproval and Factor III: active coping. At all three points in time, Factor I correlated significantly with @entity1 decrease, Factor II with increase and Factor III did not correlate with @entity1 at all. CONCLUSIONS: @entity0 with risk-pregnancies used coping strategies similar to those @entity0 in the control-group. Different spectrums of coping strategies corresponded significantly to increasing or decreasing @entity1 . These @entity0 with high levels of @entity1 , especially, should be offered sensitive care or psychotherapeutic counseling, as their coping processes did not lead to successful coping in the form of a reduction in @entity1 .

title: Coping styles of pregnant XXXX after prenatal ultrasound screening for @entity2 .

answer: @entity0


abstract: UNASSIGNED: 4616 Background: @entity4 ( @entity4 ) are known to have a phenomenon called "benign ethnic neutropenia ( @entity3 )." This is well described in both the hematology and oncology literature and has been implicated as a source of disparity in @entity1 outcomes among AAs. Since @entity4 are more likely to have pathological subtypes of @entity2 , this investigation sought to determine if absolute neutrophil count (ANC) and therefore @entity3 is associated with adverse pathologic findings following radical prostatectomy (RP) within a cohort of @entity4 @entity0 . METHODS: The IRB-approved Columbia University urologic oncology database was retrospectively reviewed for all @entity0 undergoing a RP who met inclusion criteria: @entity4 race, pre-operative CBC with differential, and known final RP pathology. @entity3 was defined as ANC level <= 1.5x10(9)/L (1.5). Clinical and pathological variables were characterized within the @entity4 cohort and linear regression analysis was performed. The primary outcome was adverse @entity1 grade, defined as Gleason score 8-10. RESULTS: From 1994 to 2010, a total of 331 @entity0 were identified. In this cohort, 18 (5.5%) @entity0 with an ANC <= 1.5 were identified; the mean age was 59.9    7.5 years and mean follow-up time was 48.9    43.1 months. There were 273 (82.48%) @entity0 with pathological Gleason score 2-7 and 58 (17.52%) @entity0 with Gleason score 8-10 (p=0.045). Between the @entity3 and non- @entity3 cohorts, there was no significant difference in age, race, preoperative PSA, gleason score, node status, or @entity1 margins (p>0.05). The two groups differed with respect to pathologic gleason score: a higher percentage of @entity3 @entity0 had Gleason score >= 8 than non- @entity3 @entity0 (38.9% vs 16.3%; p=0.045). Univariable regression analysis showed that ANC <= 1.5 was associated with adverse @entity1 grade (HR 1.25, CI 1.05-1.50; p=0.014). Multivariable regression analysis showed that ANC <= 1.5 was an independent predictor of adverse @entity1 grade (HR 1.24, CI 1.02-1.51; p=0.030). CONCLUSIONS: @entity3 in AAs predicts adverse @entity1 grade at prostatectomy. Further studies are necessary to better understand the pathogenesis of @entity2 , particularly as it relates to the African American population.

title: Does absolute neutrophil count predict adverse @entity1 grade in African American XXXX with @entity2 ?

answer: @entity0


abstract: @entity3 (PCT) is one of the precursors in the synthesis of @entity1 in thyroidal C-cells and other neuroendocrine cells. PCT, among other @entity1 precursors, is elevated in the serum of many conditions associated with a systemic @entity0 , even in the absence of the thyroid gland. The aim of our study was to identify PCT-producing extrathyroidal tissues in primate @entity2 . In order to induce PCT production, we treated four @entity5 ( @entity5 ) with the endotoxin lipopolysaccharide (LPS) from @entity4 . We found an increase in serum PCT 3 to 5 hours after LPS injection to levels of 0.2 ng/ml, attaining a peak above 4 ng/ml PCT at 10 hours. In contrast, the untreated @entity5 had no detectable circulating PCT in the serum. In one animal, additional LPS boosting after 24 hours did not increase serum PCT further. Soluble proteins were extracted from different organs, fractionated by C18 extraction, and PCT was measured in an immunoluminometric assay (ILMA), which was specifically developed for this study. PCT concentrations above 0.2 ng/g of wet tissue were found in a variety of organs in LPS treated @entity6 , but not in the control @entity5 . Organs and tissues with the highest PCT concentration included liver, kidney, aorta, fat, ovaries, bladder and adrenal gland. RT-PCR confirmed an extrathyroidal origin of PCT. Importantly, CT-mRNA expression was found in liver, lung, kidney, adrenal, colon, skin, spleen, brain and pancreas. In conclusion, our data confirm previous findings in hamsters, indicating an extrathyroidal origin for PCT in @entity2 . Our primate model offers a valuable tool for further investigation of PCT's pathophysiological role and its immunoneutralization as a therapy for @entity2 .

title: Production of XXXX (PCT) in non-thyroidal tissue after LPS injection.

answer: @entity3


abstract: Radiotherapy is an important treatment option for many @entity0 @entity1 . Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various @entity1 . The cellular response to irradiation is driven by both direct DNA damage in the targeted cell and intercellular signalling leading to a broad range of bystander effects. This study aims to elucidate radiation-induced DNA damage response signalling in bystander cells and to identify potential molecular targets to modulate the radiation induced bystander response in a therapeutic setting. Stalled replication forks in T98G bystander cells were visualised via @entity2 ( @entity2 ) nuclear foci detection at sites of single stranded DNA. yH2AX co-localised with these @entity2 foci. @entity3 and @entity6 foci formed in T98G bystander cells. Using @entity4 mutant F02-98 hTERT and ATM deficient GM05849 fibroblasts it could be shown that @entity4 but not ATM was required for the recruitment of @entity6 to sites of replication associated DNA damage in bystander cells whereas @entity3 bystander foci were ATM-dependent. Phospho- @entity5 foci formation was observed in T98G bystander cells. Clonogenic survival assays showed moderate radiosensitisation of directly irradiated cells by the @entity5 inhibitor @entity7 but increased radioresistance of bystander cells. This study identifies @entity3 , @entity6 and @entity5 as potential targets for the modulation of radiation response in bystander cells. It adds to our understanding of the key molecular events propagating out-of-field effects of radiation and provides a rationale for the development of novel molecular targeted drugs for radiotherapy optimisation.

title: XXXX , @entity6 and @entity5 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.

answer: @entity3


abstract: BACKGROUND: Elevated plasma @entity2 levels are considered to play a part in the pathophysiology of hemodialysis-related @entity1 . However, antihistaminic therapy often fails to provide sufficient relief. Elevated @entity3 levels in @entity0 on dialysis therapy have also been described but the effects of 5-HT3 receptor antagonists on hemodialysis-related @entity1 remain controversial. METHODS: we conducted a study to determine plasma @entity2 and @entity3 levels before and after treatment with 5-HT3 receptor antagonists (tropisetron 5 mg and @entity4 8 mg) and an @entity6 ( @entity5 10 mg). Eleven hemodialysis @entity0 with a history of @entity1 participated in this study,10 healthy volunteers served as control group. RESULTS: @entity2 and @entity3 values were normal in @entity0 and controls. Treatment with @entity5 did not significantly reduce @entity2 levels in @entity0 or in controls. Tropisetron and ondansetron likewise did not alter @entity3 levels in @entity0 . Tropisetron treatment did not significantly change @entity3 levels in controls. CONCLUSION: @entity2 and @entity3 are no major mediators of @entity1 in hemodialysis @entity0 . Elevated @entity2 levels are occassionally seen and may be due to the increased mast cell number found in a subgroup of hemodialysis @entity0 . Our findings explain the only marginal relief of antihistamines and the controversial antipruritic effect of @entity3 receptor antagonists in hemodialysis-related @entity1 .

title: Plasma XXXX and @entity2 levels in hemodialysis-related @entity1 are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy.

answer: @entity3


abstract: This study was carried out for three years from 1968 to 1970. Three coastal villages and four remote islets of Che Ju Island were surveyed and 90% of all inhabitants were blood smeared. These study areas were grouped into five according to its characteristic for evaluation of mass treatment with @entity4 (Hetrazan U.S.P.) and insecticide spray in control of @entity0 @entity3 . To set baseline up for control group, placebo was administered. Followings are the results obtained: 1. 81.1% of all mf positives accepted and completed the mass chemotherapy; main reason for refusal was side reactions told by neighboring villagers who experienced them. 2. 6 mg of @entity4 /kg B.W. X12 doses given every day turned mf postives to mf negative in 92.1%. The @entity0 who had high mf density remained mf positive in 16.5% whereas only 2.1% for low mf density. 3. 73.8% of mf positives after the treatment showed marked decrease in mf density. Most of them to less than 15n mg/20 mm(3) of blood that can not infect mosquito effectively. 4. Mosquito infection rates were also dropped markedly in areas where mf positive were mass treated. 5. Side reaction induced by @entity4 was frequent(64%-90%) and various. The most frequent symptom was @entity1 and @entity2 . 6. DDT spray did not influence @entity0 mf rate and mosquito infection rate.

title: Efficacy Of Mass Treatment For Control Of XXXX Filariasis.

answer: @entity0


abstract: BACKGROUND: Presence of numerous diet responsive comorbidities and high @entity4 among adults with @entity2 demands attention is given to diet in an effort to delay progression of @entity10 . The aim of this study was to compare diet of adults with @entity2 : (a) against dietary recommendations; (b) following 12  weeks of supervised exercise training; and (c) against @entity10 controls. METHODS: Diet was assessed using a food frequency questionnaire pre and post supervised exercise training. Pre-exercise diet was compared against Suggested Dietary Targets and against @entity10 controls matched for gender, age and body weight. Pre-exercise diet was also compared against post-exercise diet. RESULTS: Pre-exercise 25/31 @entity0 , 5/31 @entity0 , 16/31 @entity0 and 4/31 @entity0 achieved recommendations for protein, @entity9 , total fat and saturated fat respectively. Few achieved recommended intakes for fibre (3/31 @entity0 ), @entity1 (8/31 @entity0 ), @entity8 (11/31 @entity0 ), @entity6 (1/31 @entity0 ), @entity7 (4/31 @entity0 ), @entity5 equivalents (1/31 @entity0 ) and @entity3 (3/31 @entity0 ). There were no differences observed between @entity0 compared to controls in achievement of recommendations. Post-exercise, marginally more @entity0 were able to achieve targets for @entity1 , @entity7 and @entity3 but not for any other nutrients. CONCLUSIONS: Despite evidence to support benefits of dietary modification in risk reduction of @entity10 , adults with @entity2 continue to consume poor diets. Research is required to determine whether dietary changes can be achieved with greater attention to nutrition counselling and the impact assessed in terms of delayed disease progression and long term health outcomes. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01871779.

title: Change in dietary intake of adults with XXXX undergoing a supervised exercise program and compared to matched controls.

answer: @entity2


abstract: Ninety-four @entity0 with classical @entity1 are reviewed. Early treatment with a low @entity2 diet usually results in normal or near-normal I.Q. Twenty-seven of the 38 @entity0 diagnosed before 2 months of age have an I.Q. in the normal range. Of the other 11, six are dull normal, four are borderline and one is @entity3 . Adequate reasons are given for the less than optimal results in these 11 early-treated @entity0 . Twenty-one of the 28 @entity0 presenting with abnormal electroencephalograms showed normal tracings soon after initiation of diet and four of the other seven improved. Nine of 12 on continuous anticonvulsant medication at the time of presentation were able to discontinue this soon after institution of dietary measures. Eighteen of the 19 sibling pair comparisons revealed a better ultimate I.Q. in the early-treated sib. A plea for early diagnosis by continuation of newborn screening programs and for centralization of diagnostic confirmation and treatment is made.

title: The efficacy of dietary therapy for XXXX .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Organized acute @entity1 treatment reduces mortality, functional deficits, and the need of institutionalization after @entity1 . It is largely unknown whether the effects of treatment are due to early or subacute efforts. The aim of this randomized, controlled study was to test the hypothesis that rehabilitation of @entity1 @entity0 in the subacute phase in a hospital rehabilitation unit is beneficial in reducing @entity2 and dependency and increasing health-related quality of life. METHODS: 251 @entity0 initially treated in the hospital were randomized to subacute rehabilitation in a hospital rehabilitation unit (n = 127) or to the health services in the municipality (n = 124) and were followed up for 7 months. RESULTS: The combined outcome of @entity0 being dead or dependent (Barthel Index score of < 75) was 23% in the hospital group and 38% in the municipality group (P=.01). Seven-month survival rates were 90.6% and 83.9% (P=.11), respectively. Dependency in activities of daily living was 12.6% in the hospital group and 25.0% in the municipality group (P=.07). @entity0 with a BI score of < 50 before rehabilitation had significantly better outcome in the hospital rehabilitation unit, with fewer @entity0 becoming dependent (P=.005) and @entity0 having higher Scandinavian @entity1 Scale (P=.026) and BI scores (P=.005). No significant differences in health-related quality of life were found. Many @entity0 treated in the municipalities (30%) did not receive any organized rehabilitation in this study. CONCLUSIONS: Subacute rehabilitation of @entity1 @entity0 in a hospital-based rehabilitation unit improves outcome. @entity0 with moderate or severe @entity1 appear to benefit most.

title: Outcome of subacute XXXX rehabilitation: a randomized controlled trial.

answer: @entity1


abstract: AIM: In this study, it was aimed to investigate which method was superior by applying selective head cooling or whole body cooling therapy in newborns diagnosed with moderate or severe @entity2 ischemic @entity1 . MATERIALS AND METHOD: Newborns above the 35th gestational age diagnosed with moderate or severe @entity2 ischemic @entity1 were included in the study and selective head cooling or whole body cooling therapy was performed randomly. The newborns who were treated by both methods were compared in terms of adverse effects in the early stage and in terms of short-term results. Ethics committee approval was obtained for the study (06.01.2010/35). RESULTS: Fifty three babies diagnosed with @entity2 ischemic @entity1 were studied. Selective head cooling was applied to 17 babies and whole body cooling was applied to 12 babies. There was no significant difference in terms of adverse effects related to cooling therapy between the two groups. When the short-term results were examined, it was found that the hospitalization time was 34 (7-65) days in the selective head cooling group and 18 (7-57) days in the whole body cooling group and there was no significant difference between the two groups (p=0.097). Four @entity0 in the selective head cooling group and two @entity0 in the whole body cooling group were discharged with tracheostomy because of the need for prolonged mechanical ventilation and there was no difference between the groups in terms of discharge with tracheostomy (p=0.528). Five @entity0 in the selective head cooling group and three @entity0 in the whole body cooling group were discharged with a @entity3 because they could not be fed orally and there was no difference between the groups in terms of discharge with a @entity3 (p=0.586). One @entity0 who was applied selective head cooling and one @entity0 who was applied whole body cooling died during hospitalization and there was no difference between the groups in terms of mortality (p=0.665). CONCLUSIONS: There is no difference between the methods of selective head cooling and whole body cooling in terms of adverse effects and short-term results.

title: Comparison of selective head cooling therapy and whole body cooling therapy in newborns with XXXX ischemic @entity1 : short term results.

answer: @entity2


abstract: AIMS: We performed a network meta-analysis of randomized controlled trials (RCTs) in @entity0 with @entity4 to compare the impact of proprotein convertase subtilisin-kexin type 9 @entity6 protease ( @entity7 ) inhibitors with placebo and @entity8 on lipid levels and outcomes. METHODS AND RESULTS: MEDLINE/PubMed, Cochrane CENTRAL, and ClinicalTrials.gov were searched for RCTs assessing @entity7 inhibitors vs. other therapies in @entity0 with @entity4 . Network meta-analysis with both a frequentist approach and a Bayesian framework was performed to directly and indirectly compare @entity7 inhibition on lipid levels with @entity8 and placebo. Odds ratios with 95% confidence intervals (OR [95% CIs]) were generated with random-effects models to compare outcomes. Our meta-analysis included 17 RCTs with 13 083 @entity0 that were randomized to @entity7 inhibitors (n = 8250), placebo (n = 3957), @entity8 (n = 846), or @entity7 inhibitors and @entity8 (n = 30). The mean age was 59    10, 52% were male, 34% had @entity5 , 51% had @entity2 , 19% had @entity1 , baseline LDL of 122    36 mg/dL, total @entity3 of 199    39 mg/dL, and HDL of 51    14 mg/dL. inhibitors significantly reduced LDL @entity3 by 57% relative to placebo (P < 0.001) and 36.1% relative to @entity8 (P < 0.001). Proprotein convertase subtilisin-kexin type 9 @entity6 protease inhibitors reduced the incidence of all-cause mortality [OR 0.43 (95% CI 0.22-0.82), P = 0.01] but was associated with an increased incidence of neurocognitive adverse events [OR 2.34 (95% CI 1.11-4.93), I(2) = 4%, P = 0.02] when compared with placebo. CONCLUSION: Proprotein convertase subtilisin-kexin type 9 @entity6 protease inhibition significantly improved lipid profiles and reduced the incidence of all-cause mortality compared with placebo but had a higher rate of neurocognitive adverse events. Thus, @entity7 inhibitor therapy may serve as an alternative for @entity0 with statin intolerance and for those who do not respond to other lipid reduction therapy.

title: The impact of proprotein convertase subtilisin-kexin type 9 XXXX protease inhibitors on lipid levels and outcomes in @entity0 with @entity4 : a network meta-analysis.

answer: @entity6


abstract: UNASSIGNED: @entity10 red pulp small @entity8 (SDRPL) is considered an indolent @entity1 and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL @entity0 , 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and @entity12 rearrangements in 3, with @entity11 and potentially @entity14 as partners in each one of them. Copy number arrays showed aberrations in 69% of the @entity1 , including recurrent losses of 10q23, 14q31-q32, and 17p13 in 3, and 9p21 in 2 cases. Deletion of 7q31.3-q32.3 was present in only 1 case and no trisomies 3 or 18 were detected. @entity2 and @entity13 were mutated in 2 cases each, whereas @entity6 , @entity7 , and @entity15 were mutated each in single cases. No mutations were found in @entity3 or @entity9 . Four of the 5 @entity0 with @entity4 had mutations in @entity2 (2 cases), @entity7 (1 case), and @entity13 (1 case). The progression-free survival of @entity0 with mutated genes was significantly shorter than in the unmutated (P=0.011). These findings show that SDRPL share some mutated genes but not chromosomal alterations, with other @entity5 , that may confer a more @entity4 .

title: @entity2 , @entity7 , and XXXX Mutations in Splenic Diffuse Red Pulp @entity8 Are Associated With Progressive Disease.

answer: @entity13


abstract: Antibodies were raised to @entity1 ( @entity1 ) enriched fractions obtained from brains of individuals with @entity2 by extraction with ionic detergent followed by @entity4 gradient centrifugation. Electron microscopic examination showed that the fractions were enriched in @entity2 but contained also lipofuscin, amyloid, granular material and membranous elements. Analysis of these fractions with @entity3 -PAGE stained with Coomassie blue showed only a faint band at approximately 60 kDa while most of the material was excluded from the stacking gel. BALB/c @entity0 were injected weekly with 100 or 200 micrograms of these fractions or corresponding fractions from age-matched control brains. The 3 @entity0 injected with Alzheimer brain, but not the 5 @entity0 injected with control brain fractions, produced antibodies that reacted with central and peripheral nervous system axons, @entity5 in intact tissue as well as with isolated, @entity3 -treated paired helical filaments. In gel strips antibodies from all 3 @entity0 injected with Alzheimer brain fractions reacted with the 200-kDa and 168-kDa but not the 68-kDa neurofilament subunits. The 3 antisera reacted also with some forms of the @entity6 . Adsorptions with the insoluble fraction from Alzheimer but not from control brains blocked staining of axons and NFT by all 3 antisera. Adsorption with highly purified neurofilament proteins or with a preparation containing the 200-kDa and 168-kDa neurofilament subunits blocked axon and NFT immunostaining only in one antiserum. Adsorptions with microtubule protein, heat-stable microtubule-associated protein, or a preparation of tau did not completely block immunostaining by any of the 3 antisera. These results demonstrate that fractions enriched with @entity2 helical filaments contain insoluble neurofilament, tau and other yet unidentified antigens.

title: Antibodies to the neuronal cytoskeleton are elicited by Alzheimer XXXX fractions.

answer: @entity1


abstract: UNASSIGNED: Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm.   Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of @entity0 . @entity1 , or @entity0 composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. @entity4 has only been rarely reported in various cutaneous @entity0 .   We report a case of an elderly male presenting with a 5 millimeter erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based @entity0 with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged, bland-appearing epithelioid cells. @entity2 , EMA, and mCEA immunohistochemical stains were positive, consistent with adnexal differentiation. PTAH and LFB stains highlighted the cytoplasmic granules, consistent with mitochondria.   The overall findings were consistent with oncocytic nodular @entity3 . Oncocytic @entity3 is a very rare entity, with only 1 previously reported case in the literature.

title: A Rare Case of XXXX .

answer: @entity3


abstract: Micelacking both @entity11 and both @entity12 K+ channel alleles display severe @entity1 such as @entity5 , @entity7 , and @entity8 . Micelacking one to three alleles at the @entity11 and Kv3.3 loci exhibit in an allele dose-dependent manner a modest degree of @entity8 . Cerebellar granule cells coexpress @entity11 and Kv3.3 K+ channels and are therefore candidate neurons that might be involved in these @entity3 . Hence, we investigated the synaptic mechanisms of transmission in the parallel fiber-Purkinje cell system. Action potentials of parallel fibers were broader in @entity0 lacking both @entity11 and both @entity12 alleles and in @entity0 lacking both @entity11 and a single @entity12 allele compared with those of wild-type @entity0 . The transmission of high-frequency trains of action potentials was only impaired at 200 Hz but not at 100 Hz in @entity0 lacking both @entity11 and Kv3.3 genes. However, paired-pulse facilitation (PPF) at parallel fiber-Purkinje cell synapses was dramatically reduced in a gene dose-dependent manner in @entity0 lacking @entity11 or @entity12 alleles. Normal PPF could be restored by reducing the extracellular @entity2 concentration indicating that increased activity-dependent presynaptic @entity2 influx, at least in part caused the altered @entity10 in mutant @entity0 . Induction of metabotropic @entity9 receptor-mediated EPSCs was facilitated, whereas longterm @entity4 was not impaired but rather facilitated in @entity11 / @entity12 double-knockout @entity0 . These results demonstrate the importance of Kv3 @entity6 channels in regulating the dynamics of synaptic transmission at the parallel fiber-Purkinje cell synapse and suggest a correlation between short-term plasticity at the parallel fiber-Purkinje cell synapse and motor performance.

title: Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in XXXX lacking @entity6 channels Kv3.1 and Kv3.3.

answer: @entity0


abstract: PURPOSE: To describe the operative procedure and report the clinical outcomes of articular surface reconstruction for various @entity4 using autologous osteochondral grafts from the knee. METHODS: Ten @entity0 underwent articular surface reconstruction for @entity4 with autologous osteochondral grafts from the patellofemoral joint. Mean @entity0 age was 35 years (range, 15-52 y). The @entity0 were followed for an average of 48 months (range, 16-89 mo). Arthroplasty was performed on the metacarpophalangeal joint in 4 cases, and on the proximal interphalangeal joint in 6 cases. The @entity0 ' clinical outcomes were evaluated with joint range of motion, visual analog scale (0-10 points), and Disabilities of the Arm, Shoulder, and Hand (DASH) score. Histological examination was performed in 3 cases after surgery. RESULTS: Graft union was confirmed in all cases without radiographic evidence of resorption or @entity1 . Follow-up radiographic examinations showed good graft incorporation without signs of @entity3 such as joint space narrowing. The finger flexion-extension arc improved significantly from an average of 21   to 61  . The mean visual analog scale also improved significantly from 7.0 to 1.5. The mean total active motion showed a significant improvement from 151   before surgery to 201   after surgery, and the mean DASH score improved significantly from 33 to 12. There were no significant differences for the arc of finger motion and DASH score between metacarpophalangeal and proximal @entity4 or between hemiarthroplasty and @entity4 . Histological examination revealed viable chondrocytes in the implanted cartilage. CONCLUSIONS: Autologous osteochondral grafting from the patellofemoral joint provided satisfactory outcomes and may be a useful option for joint surface reconstruction of traumatic or @entity2 . TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

title: Joint Arthroplasty With Osteochondral Grafting From the Knee for Posttraumatic or XXXX .

answer: @entity2


abstract: @entity2 can not always be done immediately because of long waiting lists. In this study, 209 consecutive @entity0 (mean age 48 years, 93% female) with a @entity1 were randomized into 3 groups: immediate operation or 1 year waiting with or without foot orthoses. The follow-up period was 2 years. The main outcome measurement was the intensity of @entity1 during walking. During the first year, 64/71, 0/69 and 4/69 @entity0 were operated on in the surgery, orthosis and no orthosis groups, respectively, and during the 2-year follow-up, 66, 43 and 48, respectively. At the 1-year follow-up, the @entity1 was least intense in the surgery group. At the 2-year follow-up, the intensity of @entity1 was similar in all groups. The satisfaction with treatment was best in the surgery and orthosis groups. The total costs of care were similar in all groups. We conclude that immediate operation is superior to delayed operation or foot orthoses. However, if this is not possible because of limited possibilities for surgery, waiting for 1 year, with or without an orthosis, does not jeopardize the final outcome.

title: @entity2 : immediate operation versus 1 year of waiting with or without orthoses: a randomized controlled trial of 209 XXXX .

answer: @entity0


abstract: One-hundred-fourteen consecutive cases of venography after primary uncemented total hip replacement were performed in a randomized trial to identify the natural incidence of @entity7 , the effectiveness of prophylactic regimens such as 1.2 grams of @entity3 daily and low-molecular-weight dextran for 3 days, and other relative factors for the development of @entity2 . In addition, intraoperative venography was conducted in 10 @entity0 to study the speed of the flow of contrast media in the femoral vein and the development of @entity7 and the extent of the twisting of the femoral vein during hip joint manipulation. The incidence of @entity2 in the control, @entity3 , and dextran prophylaxis groups were 20%, 11.5%, and 5.2% respectively. The incidence in the @entity3 group was reduced, but this was statistically insignificant. The dextran group showed a marked decrease in incidence, and the difference with the control group was statistically significant. With regard to the development site of @entity2 , it was prevalent in iliofemoral, lower femoral, and major @entity5 vein in the control group, while the popliteal and major @entity5 vein were the major site of @entity6 development in the @entity3 and dextran groups. The risk factors affecting the incidence of the @entity2 are confirmed to be @entity1 and long-term administration of @entity4 . Hematologic analysis was meaningless in investigating the development of @entity2 . The reliable clinical sign and symptom suggestive of the development of @entity2 was the severe swelling on the entire portion of affected lower extremity. In the intraoperative venogram, no correlation was found between the venous blood flow speed and the development of @entity8 . A remarkable change in the blood flow of the femoral vein was noticed when the hip joint was flexed an average of 40.4 degrees, adducted at 11.5 degrees, and internally rotated at 81.5 degrees. Especially, when the joint was internally rotated, severe kinking of the vein could be observed. Thus it seems desirable to reduce the duration of internal rotation of the hip joint as much as possible to prevent @entity2 .

title: XXXX after uncemented total hip replacement.

answer: @entity7


abstract: Background: To support cancer therapy, development of low cost library preparation techniques for targeted next generation sequencing (NGS) is needed. In this study we designed and tested a PCR-based library preparation panel with limited target area for sequencing the top 12 somatic mutation hot spots in @entity0 on the GS Junior instrument. Materials and Methods: A multiplex PCR panel was designed to amplify regions of mutation hot spots in 12 selected genes ( @entity9 , @entity6 , @entity12 , @entity3 , @entity16 , @entity8 , @entity14 , @entity13 , @entity15 , @entity11 , @entity10 , @entity7 ). Amplicons were sequenced on a GS Junior instrument using ligated and barcoded adaptors. Eight samples were sequenced in a single run. Colonic DNA samples (8 normal mucosa; 33 @entity4 ; 17 @entity2 ) as well as HT-29 and Caco-2 cell lines with known mutation profiles were analyzed. Variants found by the panel on @entity9 , @entity6 , @entity8 and @entity14 genes were validated by conventional sequencing. Results: In total, 34 kinds of mutations were detected including two novel mutations ( @entity16 c.1740:C>G and @entity10 @entity17 ) that have not been recorded in mutation databases, and one potential germline mutation ( @entity9 ). The most frequently mutated genes were @entity9 , @entity7 and @entity8 with 30%, 15% and 21% frequencies in @entity4 and 29%, 53% and 29% frequencies in @entity1 , respectively. In cell lines, all the expected mutations were detected except for one located in a homopolymer region. According to re-sequencing results sensitivity and specificity was 100% and 92% respectively. Conclusions: Our NGS-based screening panel denotes a promising step towards low cost @entity0 genotyping on the GS Junior instrument. Despite the relatively low coverage, we discovered two novel mutations and obtained mutation frequencies comparable to literature data. Additionally, as an advantage, this panel requires less template DNA than sequence capture @entity5 panels currently available for the GS Junior instrument.

title: Construction of a multiplex mutation hot spot PCR panel: the first step towards XXXX genotyping on the GS Junior platform.

answer: @entity0


abstract: PURPOSE: Traditional survival analytical tools do not reveal the ability of significant prognostic factors to predict (that is, explain variation in) survival. We used survival data in @entity0 with @entity3 to illustrate how the association of factors with survival diverges from their ability to explain @entity2 was included as a point of general comparison. MATERIALS AND METHODS: We used the 1973 to 1990 records of the Surveillance Epidemiology and End Results program. Multivariate proportional hazards models were used to identify factors that significantly associated with survival. The proportion of variation explained by these factors was estimated with the Schemper method. RESULTS: The dataset included 10,636 @entity0 with @entity3 and 1,070 with @entity2 . Median survival was significantly longer in prostate than @entity2 ; other characteristics were similarly distributed. Age, stage and marital status were associated with survival in both @entity1 (p value range 0.0001 to 0.0009). The total proportion of variation explained was 7.1% and 32.1% for prostate and @entity2 , respectively. In @entity3 , age, stage and marital status explained 0.6, 5.5 and 0.4%, of the adjusted proportion of variation explained, respectively, and in @entity2 , they explained 14.7, 8.9 and 0.6%, respectively. CONCLUSIONS: Proportional hazards models identified but did not reveal the ability of significant prognostic factors to explain variations in survival. The proportion of variation explained analyses illustrate why predicting survival is so difficult, especially in @entity3 . The prognostic factors used do not possess the ability to explain variation in survival; new prognostic factors must be identified.

title: Variation in XXXX survival explained by significant prognostic factors.

answer: @entity3


abstract: PURPOSE: To identify key genes related to the effect of @entity1 on @entity0 . METHODS: Microarray data (GSE22600) were downloaded from Gene Expression Omnibus. Eight @entity1 and seven placebo treatment samples were obtained using a 2  *  2 factorial designs, which contained 2 cell lines (PEO4 and 2008) and 2 treatments ( @entity1 and placebo). Differentially expressed genes were identified by Bayesian methods, and the genes with P  <  0.05 and  log2FC (fold change)   >= 0.5 were chosen as cut-off criterion. Differentially co-expressed genes (DCGs) and differentially regulated genes (DRGs) were, respectively, identified by DCe function and DRsort function in DCGL package. Topological structure analysis was performed on the important transcriptional factors (TFs) and genes in transcriptional regulatory network using tYNA. Functional enrichment analysis was, respectively, performed for @entity6 and the important genes using Gene Ontology and KEGG databases. RESULTS: In total, 465 @entity6 were identified. Functional enrichment analysis of @entity6 indicated that @entity7 , @entity3 , @entity5 and MYC involved in TGF-beta signaling pathway. The 2285 DCG pairs and 357 DRGs were identified. Topological structure analysis showed that 52 important TFs and 65 important genes were identified. Functional enrichment analysis of the important genes showed that @entity2 and @entity4 participated in DNA damage response and the genes ( @entity7 , @entity3 , @entity5 and MYC) involved in TGF-beta signaling pathway. CONCLUSION: @entity2 , @entity4 , @entity7 , @entity3 and @entity5 might participate in the pathogenesis of @entity0 .

title: Identification of key genes associated with the effect of XXXX on @entity0 using microarray analysis.

answer: @entity1


abstract: [Purpose] To investigate the effects of Phase II cardiac exercise therapy (CET) on exercise capacity and changes in coronary risk factors (CRFs) of @entity0 with @entity3 ( @entity3 ). [Subjects] Thirty male subjects with @entity3 were divided into an experimental group (EG) and a control group (CG). Another 30 age-matched subjects with patent coronary arteries served as a normal-control group (NCG). [Methods] Subjects in EG (n=20) trained using a stationary bicycle for 30   min at their target heart rate twice a week for 8 weeks. Exercise capacity was defined as the maximal @entity2 ( @entity2 ) that subjects reached during the symptom-limited maximal exercise test. HR, BP and RPP were recorded. Subjects in EG and CG received exercise tests and screening for CRFs at the beginning of, end of, and 3 months after Phase II CET, while subjects in NCG participated only in the 1st test. [Results] @entity2 of CG did not improve until the 3rd test, while RPP at the 2nd test showed a significant increase. However, EG showed increased @entity2 at the 2nd test without increase of RPP, and increased their high density lipoprotein @entity1 (HDL-C) during the follow-up period between the 2nd and 3rd tests. [Conclusion] Phase II CET shortens the recovery time of exercise capacity, helps to maintain the gained exercise capacity and increases HDL-C in phase III.

title: Supervised Phase II Cardiac Exercise Therapy Shortens the Recovery of Exercise Capacity in XXXX with Acute @entity3 .

answer: @entity0


abstract: AIM: To investigated the performance of the tissue resonance interaction method (TRIM) for the non-invasive detection of @entity7 . METHODS: We performed a prospective single-center blinded pilot study of consecutive adults undergoing colonoscopy at the University Hospital in Sassari, Italy. Before @entity0 underwent colonoscopy, they were examined by the TRIMprobe which detects differences in electromagnetic properties between pathological and normal tissues. All @entity0 had completed the @entity6 -containing bowel prep for the colonoscopy procedure before being screened. During the procedure the subjects remained fully dressed. A hand-held probe was moved over the abdomen and variations in electromagnetic signals were recorded for 3 spectral lines (462-465 MHz, 930 MHz, and 1395 MHz). A single investigator, blind to any clinical information, performed the test using the TRIMprob system. Abnormal signals were identified and recorded as malignant or benign ( @entity5 or @entity8 ). Findings were compared with those from colonoscopy with histologic confirmation. Statistical analysis was performed by   (2) test. RESULTS: A total of 305 consecutive @entity0 fulfilling the inclusion criteria were enrolled over a period of 12 months. The most frequent indication for colonoscopy was @entity4 (33%). The TRIMprob was well accepted by all @entity0 ; none spontaneously complained about the procedure, and no adverse effects were observed. TRIM proved inaccurate for polyp detection in @entity0 with @entity2 ( @entity2 ) and they were excluded leaving 281 subjects (mean age 59    13 years; 107 males). The TRIM detected and accurately characterized all 12 @entity3 and 135/137 @entity8 (98.5%) including 64 adenomatous (100%) found. The method identified @entity1 and @entity8 with 98.7% sensitivity, 96.2% specificity, and 97.5% diagnostic accuracy, compared to colonoscopy and histology analyses. The positive predictive value was 96.7% and the negative predictive value 98.4%. Among the 281 non- @entity2 subjects, there were 7 cases with discordant results (2.5%) between TRIMprob and the reference standard including 5 false positive results (1.8%) and 2 false negative (0.7%) results. The main limitation of the TRIMprob system is the need for trained operators. CONCLUSION: The study confirmed that TRIM provides rapid, accurate, convenient and noninvasive means to identify individuals most likely to benefit from colonoscopy.

title: Tissue resonance interaction accurately detects XXXX : A double-blind pilot study.

answer: @entity7


abstract: PURPOSE: To explore the relation between @entity3 -related variables and @entity1 in @entity0 with severe intractable @entity2 . METHODS: A retrospective analysis of data from 136 @entity0 who had undergone a cognitive assessment on two occasions at an interval of > or =10 years. Cognitive measures included tests of memory and executive skills in addition to intelligence quotients (IQ). Details were available regarding @entity3 type and frequency in the intertest interval. RESULTS: @entity1 was severe and occurred across a wide range of cognitive functions. The frequency of generalised @entity3 was the strongest predictor of decline. Complex partial @entity3 frequency was associated with a decline in memory and executive skills but not in IQ. @entity3 -related @entity4 and advancing age carried a poor cognitive prognosis, whereas periods of remission were associated with a better cognitive outcome. Early age at onset was not implicated, and duration of @entity2 was a much less potent predictor of @entity1 than has been reported in cross-sectional studies. No evidence indicated that a higher level of cognitive function protected against @entity1 . CONCLUSIONS: Our findings, together with those from animal studies and surgically treated @entity0 , suggest that @entity3 can have a direct adverse effect on cognition and that good @entity3 control even after years of intractability can have a beneficial impact on cognitive prognosis. This study was based on individuals who merited two cognitive assessments > or =10 years apart and hence is biased in favor of those with the most severe forms of @entity2 and those with decline.

title: @entity1 in severe intractable XXXX .

answer: @entity2


abstract: UNASSIGNED: 5087 Background: There is no current standard of salvage chemotherapy in recurrent @entity2 . @entity7 is an effective third generation @entity8 compound which has no complete cross-resistance with @entity11 or @entity6 in @entity2 . The purpose of our study was to assess efficacy and tolerability of combination of @entity7 and @entity4 in second-line chemotherapy of @entity2 . METHODS: In case of disease progression following first-line chemotherapy pts received second-line chemotherapy with @entity7 130 mg/m(2) and @entity4 50 mg/m(2) q3w. @entity9 ( @entity9 ) was chosen as the primary end-point. Three investigator centers participated in the study. RESULTS: Totally 29 pts were included in this study. @entity0 were @entity8 -sensitive (PFI>12 m) in 5 (17.2%), partially @entity8 -sensitive (PFI>6 m) in 12 (41.4%), @entity8 -resistant (PFI<6 m) in 11 (38.0%) cases, in 1 (3.4%) case sensitivity of @entity0 to @entity8 was not known. Objective response rate was 55.1% (24.1% complete remissions and 31.0% partial remissions). The median @entity9 was 10.7 m. With the median f.-up of 14.8 m the median overall survival was not reached. 1-year overall survival was 89%. There were no statistically significant differences in response rate and @entity9 between @entity8 -sensitive and @entity8 -resistant @entity0 (p>0.05). The median number of cycles was 5 (range 2-6). @entity3 grade 3-4 per cycle included @entity10 14.6%, @entity10 0.7%, @entity5 5.1%. @entity1 grade 1-2 and 3 was observed in 8 (27.6%) and 2 (1.4%) cases respectively. There were 5 cases of @entity7 dose reductions and 10 cases of @entity4 dose reductions; 10 cycles of chemotherapy were delayed due to @entity3 . CONCLUSIONS: The combination of @entity7 and @entity4 showed promising efficacy in either @entity8 -sensitive or @entity8 -resistant recurrent @entity2 . Tolerability of this regimen was acceptable.

title: The phase II study of efficacy and safety of XXXX with @entity4 in recurrent @entity2 ( @entity2 ).

answer: @entity7


abstract: AIMS: The @entity1 breath test may have value in the initial assessment of @entity3 in primary care. This pilot study tracks @entity0 and general practitioner behaviour which cannot be predicted with modelling studies. METHODS: The @entity1 breath test was made available over a period of 18 months. The test was requested when general practitioners would normally have used a trial of medication or referred for endoscopy. @entity0 with a positive @entity1 breath test had early endoscopy before treatment. @entity0 with a negative @entity1 breath test were treated according to symptom response. A follow-up questionnaire was given 6-24 months after the @entity1 breath test. RESULTS: @entity1 breath tests were requested on 249 @entity0 ; clinical notes and follow-up interview data were available for 207 @entity0 (83%). The @entity1 breath test was positive for 89 @entity0 (43%); 70 were referred for endoscopy and @entity4 was found in 33 (47%). The @entity1 breath test was negative for 118 @entity0 ; 14 were follow-up tests after previous @entity2 treatment. For the 104 @entity0 with @entity3 , a negative test and no previous treatment, 42% had 1 or more previous investigations for @entity3 and 66% had @entity3 symptoms for more than one year. During follow-up, 21 @entity0 had endoscopy. Dyspepsia symptom scores were significantly lower at follow-up (p < 0.01). Using a global assessment, 66% had fewer symptoms, 22% same and 12% had more symptoms. The symptom improvement was greater if the duration of symptoms was less than one year (p < 0.05). Medication use did not change significantly. Twelve @entity0 were dissatisfied with management; most of these would have preferred endoscopy. CONCLUSIONS: A negative @entity1 breath test appears to have some reassurance value. The use of the @entity1 breath test as initial assessment for dyspespia may prevent the need for some endoscopy. Further controlled studies of breath testing compared with early endoscopy are required.

title: Can the XXXX breath test for @entity2 replace endoscopy for the assessment of @entity3 in primary care?

answer: @entity1


abstract: Acquired genomic aberrations have been shown to significantly impact survival in several @entity2 . We analyzed the prognostic value of the most frequent chromosomal changes in a large series of @entity0 with newly diagnosed symptomatic @entity1 prospectively enrolled in homogeneous therapeutic trials. All the 1064 @entity0 enrolled in the IFM99 trials conducted by the Intergroupe Francophone du My  lome benefited from an interphase fluorescence in situ hybridization analysis performed on purified bone marrow plasma cells. They were systematically screened for the following genomic aberrations: del(13), t(11;14), t(4;14), hyperdiploidy, MYC translocations, and del(17p). Chromosomal changes were observed in 90% of the @entity0 . The del(13), t(11;14), t(4;14), hyperdiploidy, MYC translocations, and del(17p) were present in 48%, 21%, 14%, 39%, 13%, and 11% of the @entity0 , respectively. After a median follow-up of 41 months, univariate statistical analyses revealed that del(13), t(4;14), nonhyperdiploidy, and del(17p) negatively impacted both the event-free survival and the overall survival, whereas t(11;14) and MYC translocations did not influence the prognosis. Multivariate analyses on 513 @entity0 annotated for all the parameters showed that only t(4;14) and del(17p) retained prognostic value for both the event-free and overall survivals. When compared with the currently used International Staging System, this prognostic model compares favorably. In @entity1 , the genomic aberrations t(4;14) and del(17p), together with @entity3 level, are important independent predictors of survival. These findings have implications for the design of risk-adapted treatment strategies.

title: Genetic abnormalities and survival in multiple XXXX : the experience of the Intergroupe Francophone du My  lome.

answer: @entity1


abstract: UNASSIGNED: @entity2 ( @entity2 ) exhibit high biological activity, they are cytotoxic, genotoxic, and are constantly released into the environment as a result of incomplete metabolism. Consequently they pose a serious threat to the environment and @entity0 health due to their carcinogenic, mutagenic and/or reproductive @entity1 properties. Knowledge of their bioavailability, including their sorption to soils and their impact on the soil-groundwater pathway, is crucial for their risk assessment. Laboratory batch and column leaching tests are important tools for determining the release potential of contaminants from soil or waste material. Batch and column tests were carried out with soils differing in physicochemical properties, each spiked with @entity3 (CK) or @entity4 (IF). Moreover, due to the fact that environmental pollutants may occur as coexisting compounds in the soil the mobility evaluation for @entity2 in the mixture with @entity5 ( @entity6 ; b-blocker) as a co-contaminant was performed. In order to assess appropriateness, the batch and column tests were compared. The release depended on the properties of both the soil and the presence of co-contaminants. The faster release was observed for coarse-grained soil with the smallest organic matter content (MS soil: 90% decrease in concentration until liquid-to-solid ratio (L/S) of 0.3Lkg(-1) for all tests' layout) than for loamy sand (LS soil: 90% decrease in concentration until ratio L/S of 0.75Lkg(-1)). @entity2 are highly mobile in soil systems. Furthermore, the decrease of mobility of @entity4 was observed with the presence of a co-contaminant ( @entity5 ) in both of the soils (in MS soil a decrease of 29%; in LS soil a decrease of 26%). The mobility of @entity3 does not depend on the presence of a contaminant for MS soil, but also exhibits a decrease of 21% in LS soil.

title: The leaching behavior of XXXX and @entity4 from soil in the presence of co-contaminant - Mixture sorption approach.

answer: @entity3


abstract: INTRODUCTION: @entity5 is the most common endocrine malignancy. In childhood, @entity5 usually behaves aggressively and relapses frequently. Nevertheless, it has a favorable prognosis. Our aim is to present our experience with pediatric @entity5 ( @entity5 ) treated at the Portuguese Institute of Oncology in Lisbon (L-PIO), between 1964 and 2006. METHODS: Review of clinical files of @entity5 in <=18-year-old @entity0 selected from the databases of the Endocrinology Service of L-PIO and the South Portugal Regional Cancer Registry (SPCR). RESULTS: 93 cases of @entity5 were found. Of these, 70 (75.3%) were @entity0 . The median age was 15 years old (range 5-18) with a median follow-up time of 15.1 years (range 0.2-47.8). The most common histological diagnosis was @entity6 of the classical variant (n=60, 64.5%). Initial @entity2 showed locoregional dissemination in 27 (29.0%) @entity0 and distant @entity1 in 16 (17.2%) @entity0 . Median age was lower in @entity0 with distant disease than in @entity0 with @entity3 or with disease confined to the thyroid (P=0.007). After the initial treatment, 44 (47.3%) @entity0 were in remission and 46 (49.5%) had persistent disease (lost follow-up in 3). Of the disease-free @entity0 after initial treatment, 11 (25.0%) relapsed later. At the last observation, most @entity0 (n=63, 67.7%) showed no evidence of disease. CONCLUSION: Our study demonstrates that @entity0 with distant metastatic disease are younger than @entity0 with a @entity4 . However, in both groups the response to treatment is favorable and the prognosis is usually excellent.

title: Review of clinical and pathological features of 93 cases of XXXX in pediatric age at the Lisbon Centre of the Portuguese Institute of Oncology between 1964 and 2006.

answer: @entity5


abstract: Several prospective studies with @entity2 as endpoint have supported @entity3 as a cause of @entity5 . However, the largest study used seroepidemiology and did not analyse presence of @entity3 DNA in the subsequent @entity1 . Linkage of serum bank registries and @entity1 registries had identified 196 @entity0 with a registered @entity5 after donation of a serum sample. For the present study, biopsies for 127 cases could be located, verified to contain @entity2 and be amplified by PCR. Three control @entity0 who had remained alive and without @entity5 during an equal length of follow-up had been matched to each of the case @entity0 and tested for HPV antibodies. Presence of @entity3 DNA in the @entity1 was analysed by general primer and type specific PCR. @entity4 -seropositive @entity0 had a relative risk of 4.4 (95% CI: 2.2-8.8) to develop @entity5 carrying @entity4 DNA. By contrast, there was no excess risk for @entity4 -seropositive @entity0 to develop @entity5 devoid of @entity4 DNA. Prediagnostic @entity4 seropositivity was strongly correlated with later @entity4 DNA positivity of the @entity1 (P<0.001) and prediagnostic HPV18 seropositivity correlated with HPV18 DNA in the @entity1 (P<0.03). The link between prediagnostic seropositivity and type of viral DNA in the @entity1 implies that the carcinogenic effect of infection with these viruses is dependent on persistent presence of type-specific viral DNA.

title: A prospective study of the relationship between prediagnostic @entity3 seropositivity and HPV DNA in subsequent cervical XXXX .

answer: @entity2


abstract: @entity5 in @entity4 has been recognized to be morphologically heterogenous, featuring adenomatous, foveolar, and hybrid phenotypes. Recent studies have suggested a @entity0 suppressor role for @entity11 in the @entity3 sequence. The phenotypic stability and role of @entity11 in the @entity0 progression of different types of @entity5 have not been evaluated. Thirty-eight endoscopic mucosal resections with @entity5 and/or @entity3 ( @entity3 ) arising in @entity4 were evaluated for the expression of @entity9 , @entity12 , @entity10 , @entity8 , and @entity11 . The background mucosa was also evaluated. The results were correlated with morphologic classification and clinicopathologic parameters. Of 38 endoscopic mucosal resections, 23 had @entity3 and @entity5 , 8 had @entity3 only, and 7 had @entity5 only. Among @entity1 , 73% were foveolar, 17% were adenomatous, and 10% were hybrid. Twenty of 23 cases with @entity5 and adjacent @entity3 showed an identical immunophenotype of @entity5 and @entity3 comprising 16 gastric, 3 intestinal, and 1 mixed immunophenotype. Three cases showed discordance of @entity5 and @entity3 immunophenotype. These findings suggest that most Barrett-related @entity3 cases are either gastric or intestinal, with phenotypic stability during progression supporting separate gastric and intestinal pathways of @entity2 . @entity11 showed gradual downregulation of expression during progression in @entity6 but not in foveolar or hybrid @entity5 , supporting a @entity0 suppressor role, at least in the intestinal pathway. @entity11 was also found to be expressed to a greater degree in @entity7 compared with nonintestinalized columnar metaplasia. Consistent with @entity11 as a @entity0 suppressor, this suggests that nonintestinalized columnar metaplasia may be an unstable intermediate state at risk for @entity0 progression.

title: Divergent expression of @entity9 , @entity12 , @entity10 , @entity8 , and XXXX in @entity5 and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to @entity2 in @entity4 ?

answer: @entity11


abstract: OBJECTIVE: To assess the frequency and significance of @entity6 infection in type 1 @entity4 . MATERIAL AND METHODS: Serum specimens from 94 @entity0 with type 1 @entity4 were tested for @entity6 RNA by reverse transcription and polymerase chain reaction. Serum samples from 50 normal subjects were also assessed. RESULTS: Three of the 94 specimens from @entity0 with @entity4 were positive for @entity6 RNA in comparison with none of the 50 control samples (3% versus 0%; P = 0.5). Two @entity0 were seropositive after @entity2 and blood transfusion, including one @entity0 who clearly acquired the infection in this fashion. One @entity0 had no epidemiologic basis for his seropositivity. @entity3 was prolonged in all infected @entity0 (mean duration, 69 +/- 23 months; range, 36 to 113); however, no clinical features suggested a concurrent @entity5 , and mortality was similar to that among the uninfected counterparts (33% versus 8%; P = 0.2). Liver transplantation was more common in the infected @entity0 (67% versus 9%; P = 0.03), but the duration of disease was also longer in these @entity0 (277 +/- 29 months versus 106 +/- 9 months; P = 0.0008). Clinical features and immediate responses to @entity1 therapy were similar in both groups. CONCLUSION: @entity6 RNA is found infrequently in type 1 @entity4 , and @entity6 is unlikely to be an important etiologic agent or prognostic determinant.

title: XXXX infection in type 1 @entity4 .

answer: @entity6


abstract: The authors present two cases of primary @entity4 ( @entity4 ) of the kidney. Both @entity0 had a mass in the upper part of the left kidney without any primary @entity3 . Grossly, the @entity1 were solid masses both measuring 7.5  cm in the greatest diameter. Histologically, one of the lesions exhibited a predominantly lobular growth of round or oval small uniform epithelioid cells in variable cellularity. Circular zones of crowded @entity1 cells alternating with hypocellular collagenous tissue in a concentric fashion around entrapped native renal tubules were distinctive. The second case was distinctive with significant cytological atypia in the neoplastic cells and prominent reactive proliferations in the trapped renal tubules. Immunohistochemically, @entity5 , @entity2 and @entity9 were diffusely positive in both. They were negative for @entity7 protein, @entity6 , and desmin, whereas @entity8 were positive in one lesion. Fluorescence in situ hybridization assay using dual staining probes detected @entity11 - @entity10 fusion in each lesion, which is characteristic molecular findings of @entity4 . One @entity0 presented widespread distant metastases at the time of diagnosis. In the other, no @entity1 deposits were detected other than primary. Both @entity0 have been alive with 30 and 10  month follow-ups, respectively. These @entity1 are 6th and 7th cases of primary renal @entity4 in the literature confirmed by FISH study, which exhibit unique and remarkable histomorphologic features.

title: Primary XXXX of kidney with variant histomorphologic features: report of 2 cases and review of the literature.

answer: @entity4


abstract: OBJECTIVE: @entity0 with @entity5 have increased risk of @entity10 . It is already known that lifestyle-related disorders and the use of antipsychotics are closely related with the progression of @entity10 in @entity4 @entity0 . @entity2 as well as @entity8 play an important role in the cause of @entity7 in Asia and Japan. Thus, we studied the prevalence of @entity3 in @entity4 inpatients in Japan using brain magnetic resonance imaging (MRI). METHOD: This cross-sectional study was performed from January 2012 to December 2013. Study @entity0 were 152 hospitalized @entity0 (61 @entity0 and 91 @entity0 ) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa City, Japan. Mean ages were 50.0 and 57.1 years old for @entity0 and @entity0 , respectively. The diagnoses (DSM-IV-TR criteria) of @entity0 were @entity5 (69.1%), @entity11 (18.4%), and other @entity4 (12.5%). We checked physical status, metabolic status of @entity9 and lipid levels, and brain MRI within 1 week of admission. RESULTS: The study group showed a significantly high prevalence of @entity1 and low high-density lipoprotein (HDL) cholesterolemia in both sexes (n = 61 in @entity0 , n = 91 in @entity0 , P < .05). In the study group, serum fasting plasma @entity9 and hemoglobin A1c levels were significantly high (n = 152, P < .05), but serum HDL @entity6 and total @entity6 were significantly low in both sexes (n = 61 in @entity0 , n = 90 in @entity0 , P < .05), and @entity12 were low in @entity0 (n = 61, P < .05). Silent @entity13 was recognized at a higher rate (n = 98, P < .05) compared with healthy controls. CONCLUSIONS: @entity0 in this study had an increased ratio of silent @entity13 compared with Japanese healthy controls, accompanied with higher ratios of @entity1 and low HDL @entity6 .

title: Increased Silent Brain Infarction Accompanied With High Prevalence of XXXX and Dyslipidemia in @entity4 Inpatients: A Cross-Sectional Study.

answer: @entity1


abstract: The antinociceptive effect of alpha(2)-adrenoceptor agonists is mediated by activation of descending inhibiting noradrenergic systems, which modulates 'wide-dynamic-range' neurones. Furthermore, they inhibit the liberation of @entity11 and endorphines and activate serotoninergic neurones. Despite this variety of antinociceptive actions, there is still little experience with alpha(2)-adrenoceptor agonists as therapeutic agents for use in @entity5 syndromes. Studies in animals and @entity0 have shown that the transdermal, epidural and intravenous administration of the alpha(2)-adrenoceptor agonist @entity8 reduces @entity3 intensity in @entity2 syndromes for periods varying from some hours up to 1 month. @entity0 suffering from lancinating or sharp @entity3 respond best to this therapy. Topically applied @entity8 (200-300 microg) relieves @entity9 in sympathetically maintained @entity3 . Epidural administration of 300 microg @entity8 dissolved in 5 ml @entity7 0.9 % has also been shown to be effective. In @entity0 suffering from @entity1 tolerant to opioids, @entity3 control has proved possible again with combinations of opioids and @entity8 . In isolated cases @entity8 has been administered epidurally at a dose of 1500 microg/day for almost 5 months without evidence for any histotoxic property of @entity8 . Side effects often observed during administration of alpha(2)-adrenoceptor agonists are @entity10 , sedation, @entity4 and @entity6 . Therapeutic interventions are usually not required.

title: [Alpha 2-adrenoceptor agonists for the treatment of XXXX ].

answer: @entity5


abstract: OBJECTIVE: Orbital complications of acute @entity2 can be severe. Nowadays, surgical drainage of intraorbital abscess formations is performed endoscopically in the majority of cases. This study aims to illustrate the Graz experience in the endoscopic treatment of orbital complications and to present our treatment algorithm. METHODS: In a retrospective study, 53 @entity0 were examined who were referred to the Department of General Otorhinolaryngology of the ENT-University Hospital Graz from 2000 to 2011. RESULTS: Of 53 @entity0 , @entity0 were affected more frequently than @entity0 (n = 37, 69.81% vs n = 16, 30.19%). The following diagnoses were obtained: 9 @entity3 , 7 @entity4 , 14 subperiosteal @entity1 , and 23 orbital @entity1 . In 16 @entity0 , a conservative therapy was administered; 37 @entity0 underwent surgery, most of them purely endoscopically (n = 31, 83.78%). Two of the @entity0 who underwent conservative treatment and 7 of those who underwent surgery experienced a recurrence (n = 9, 16.98%). CONCLUSION: Based on analysis of our recurrences, we have tried to create the optimal treatment algorithm as a point of reference in the management of orbital complications of acute @entity2 . In this way, 7 of 9 recurrences could have been avoided, equaling a hypothetical recurrence rate of 3.77% instead of 16.98% (hypothetical success rate 96.23%).

title: Transnasal Endoscopic Treatment of Orbital Complications of Acute XXXX : The Graz Concept.

answer: @entity2


abstract: BACKGROUND: Colorectal resection is performed in a majority of @entity0 presenting with large @entity1 of mid and lower rectum; however, it may negatively and irreversibly impact postoperative rectal function. To avoid such unfavourable outcomes, we propose an original technique combining laparoscopic deep rectal shaving and transanal disc excision using a semi-circular stapler. METHODS: The video presents the procedure performed in a 29-year-old nullipara referred with a large endometriotic nodule infiltrating the lower rectum on more than 30  mm length. The first step is laparoscopic and involves deep rectal shaving performed using exclusively the plasma energy. Then, transanal excision of shaved area is performed, by placing traction parachute sutures in the middle and outside the shaved area. Their traction induces the prolapse of shaved area that is resected using a semicircular stapler. Insufflating the rectum with air checks the integrity of the staple line. RESULTS: Operative time was 210  min. Immediate postoperative outcomes were uneventful, and bowel movements were normal beginning with day 6. Our technique is suitable in large rectal nodules located up to 10  cm above the anus, infiltrating the rectum on up to 6  cm length, and these parameters are preoperatively assessed using MRI and computed tomography. To date, it was successfully carried out in 29 @entity0 with large deep @entity1 of the mid and lower rectum. @entity3 was recorded in one @entity0 (3.6  %) and transitory @entity2 in seven @entity0 (25  %). Digestive function assessment using standardized questionnaires revealed an overall improvement, without de novo anal continence troubles. Postoperative pregnancy rate was 78  % with a majority of @entity0 having conceived spontaneously. CONCLUSIONS: Based on our experience, we believe that our conservative technique is feasible and reproducible in large mid and lower @entity1 and might avoid the risk of unfavourable outcomes related to low colorectal resection.

title: Deep shaving and transanal disc excision in large XXXX of mid and lower rectum: the Rouen technique.

answer: @entity1


abstract: New crown-appended @entity0 -based organogelator 1, which has two @entity0 skeletons as a chiral aggregate-forming site, two @entity3 groups as an acidic proton-binding site, and one crown moiety as a cation-binding site, was synthesized, and the gelation ability was evaluated in organic solvents. It can gelate @entity4 , @entity5 , @entity2 , @entity1 , @entity12 , @entity11 , @entity8 , and @entity10 under 1.0 wt %, indicating that 1 acts as a versatile gelator of various organic solvents. To characterize the aggregation mode in the organogel system, we observed a CD spectrum of the @entity4 gel 1. In the CD spectrum, the lambda(theta)=0 value appears at 353 nm, which is the same as the absorption maximum lambda(max) = 353 nm. The positive sign for the first @entity6 effect indicates that the dipole moments of @entity14 chromophores tend to orient in a clockwise direction. Very surprisingly, the TEM images of the 1 + @entity4 gel resulted in the helical ribbon and the tubular structures. @entity9 -gel polymerization of @entity13 was carried out using 1 in the gel phase. The @entity7 obtained from the 1 + @entity4 gel showed the helical ribbon with 1700-1800-nm pitches and the tubular structure of the @entity7 with approximately 560-nm outer diameter. As far as can be recognized, all the helicity possesses a right-handed helical motif. Since the exciton-coupling band of the organogel also shows R (right-handed) helicity, we consider that a microscopic helicity is reflected by a macroscopic helicity.

title: Helical ribbon aggregate composed of a crown-appended XXXX derivative which acts as an amphiphilic gelator of organic solvents and as a template for chiral @entity7 transcription.

answer: @entity0


abstract: BACKGROUND: @entity1 disorders are common in both intensive care units and in @entity0 with @entity2 and are associated with increased morbidity and mortality. It is unknown whether @entity1 abnormalities in unselected emergency department admissions have an impact on in-hospital mortality. METHODS: This cross-sectional analysis included all admissions to the Emergency Department at the Inselspital Bern, Switzerland from 2010 to 2011. For hyper- and hypocalcaemic @entity0 with a Mann-Whitney U-test, the differences between subgroups divided by age, length of hospital stay, @entity4 , @entity5 , @entity7 , @entity8 , @entity3 and @entity6 were compared. Associations between @entity1 disorders and 28-day in-hospital mortality were assessed using the Cox proportional hazard regression model. RESULTS: 8,270 @entity0 with @entity1 measurements were included in our study. Overall 264 (3.2%) @entity0 died. 150 @entity0 (6.13%) with hypocalcaemia and 7 @entity0 with hypercalcaemia (6.19%) died, in contrast to 104 normocalcaemic @entity0 (1.82%). In univariate analysis, @entity1 serum levels were associated with sex, mortality and pre-existing diuretic therapy (all p<0.05). In multivariate Cox regression analysis, hypocalcaemia and hypercalcaemia were independent risk factors for mortality (HR 2.00 and HR 1.88, respectively; both p<0.01). CONCLUSION: Both hypocalcaemia and hypercalcaemia are associated with increased 28-day in-hospital mortality in unselected emergency department admissions.

title: XXXX Disorders in the Emergency Department: Independent Risk Factors for Mortality.

answer: @entity1


abstract: OBJECTIVES: We evaluated the effects of irradiation, @entity3 and @entity2 on @entity0 @entity1 cells, investigating whether @entity2 and @entity3 can alter the irradiation cytotoxicity of PC-3 cells. METHODS: We used the @entity0 @entity1 cells, analyzing cell growth with @entity4 exclusion, indices of the cell cycle with flow cytometry and apoptosis with flow cytometry and analysis of DNA fragmentation on simple agarose gel. RESULTS: @entity3 (100 nM) arrested cell cycle at the G2/M phase, decreased cell growth and produced apoptosis of PC-3 cells in a time-dependent manner. @entity2 (100 nM) increased the distribution of PC-3 cells at G0/G1 phase in the cell cycle, exerting an inhibitory effect on the proliferation of PC-3 cells after 48 and 72 hr, but it did not produce apoptosis. Irradiation (4 Gy) initially arrested cells at the G2/M phase in the cell cycle (24 hr) which was gradually overcome and the PC-3 cells were shifted into G0/G1 phase or apoptosis after 48 and 72 hr. Irradiation decreased the PC-3 cell growth by 40-50% after 48 and 72 hr, respectively. Treatment with @entity3 (100 nM) for 24, 48, and 72 hr after irradiation potentiated irradiation cytotoxicity of PC-3 cells. @entity2 treatment 24 hr before and 24, 48 and 72 hr after irradiation increased the number of surviving PC-3 cells and partially neutralized the irradiation effects on cell cycle. CONCLUSION: @entity3 potentiated while @entity2 partially reversed the irradiation cytotoxicity of PC-3 cells. These data may be of clinical importance for the treatment of hormone @entity1 .

title: Response of @entity1 cells to combination therapy using irradiation with glucocorticoids or XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity1 is a multisystemic @entity3 disease of unknown aetiology. Neurologic manifestations are found in 5 to 10% of cases. @entity0 AND METHODS: We conducted a retrospective study over 6-year period including 18  @entity0 diagnosed with @entity5 in the Neurologic department of the Military Hospital of Instruction of Tunis. Clinical, radiological, therapeutic features and outcome were studied. RESULTS: The mean age was 43.44  years. Neurologic signs were the first symptom in 10  cases. @entity4 was often found. @entity2 was noted in 8  cases. Biological tests are not contributive for the diagnosis. The brain magnetic resonance imaging was pathologic in 10  cases. Corticosteroids were administrated in the majority of cases. Eight @entity0 did not show any sign of improvement. Ten cases improved with treatment. DISCUSSION AND CONCLUSION: Diagnosis of @entity5 is difficult because of its clinical and radiological polymorphism. It is based on a clinical history suggestive of @entity5 , laboratory, imaging and histological studies.

title: [Neurologic manifestations of XXXX : A study of 18  cases].

answer: @entity1


abstract: AIM: To compare the efficacy of antibiotics therapy alone with antibiotics and @entity4 boulardii in treatment of acute @entity8 . METHODS: In a double blind, random clinical trial on @entity0 with @entity9 , 57 adult @entity0 with acute @entity8 , diagnosed with clinical manifestations ( @entity6 ) and amebic trophozoites engulfing RBCs found in stool were enrolled in the study. Regimen 1 included @entity7 (750 mg Tid) and @entity10 (630 mg Tid) for 10 days. Regimen 2 contained capsules of lyophilized @entity4 boulardii (250 mg Tid) orally in addition to regimen 1. @entity0 were re-examined at two and four weeks after the treatment, and stool examination was performed at the end of week 4. Student's t-test, chi(2) and McNemar's tests were used for statistical analysis. RESULTS: Three @entity0 refused to participate. The other 54 @entity0 were randomized to receive either regimen 1 or regimen 2 (Groups 1 and 2 respectively, each with 27 @entity0 ). The two groups were similar regarding their age, sex and clinical manifestations. In Group 1, @entity3 lasted 48.0+/-18.5 hours and in Group 2, 12.0+/-3.7 hours (P<0.0001). In Group 1, the durations of @entity2 and @entity5 were 24.0+/-8.8 and 24.0+/-7.3 hours and in Group 2 they were 12.0+/-5.3 and 12.0+/-3.2 hours, respectively (P<0.001). Duration of @entity1 was similar in both groups. At week 4, amebic cysts were detected in 5 cases (18.5 %) of Group 1 but in none of the Group 2 (P<0.02). CONCLUSION: Adding @entity4 boulardii to antibiotics in the treatment of acute @entity8 seems to decrease the duration of clinical symptoms and cyst passage.

title: Efficacy of XXXX boulardii with antibiotics in acute @entity8 .

answer: @entity4


abstract: PURPOSE: Ictal motor phenomena play a crucial role in the localization of @entity2 focus in the management of refractory focal @entity1 . While the importance of unilateral @entity5 is well established, little attention is paid to the contralateral relatively immobile limb. In cases where @entity5 mimic @entity7 and in the absence of previously well-established signs, unilateral relative ictal immobility (RII) is potentially useful as a lateralizing sign. This study was carried out to examine the lateralizing value of this sign and to define its characteristics among @entity0 of refractory focal @entity1 . METHODS: VEEGs of 69 consecutive @entity0 of refractory focal @entity1 who had undergone @entity1 surgery at our center over last four years were reviewed and analyzed for the presence of RII. Unilateral RII was defined as a paucity of movement in one limb lasting for at least 10s while the contralateral limb showed @entity3 (in the absence of @entity4 or clonic movements in the involved limb). The findings were seen in the light of VEEG, radiological and nuclear imaging data, and with post-surgical outcome. RESULTS: Unilateral RII as a lateralizing sign was found in 24 of 69 @entity0 (34.78%), consisting of both temporal and extra @entity6 , with 100% concordance with VEEG and MRI data. All @entity0 demonstrating this sign had a good post-surgical outcome. CONCLUSION: RII, when well characterized is a frequent and reliable lateralizing sign in @entity0 of refractory focal @entity1 .

title: Lateralizing value of unilateral relative ictal immobility in @entity0 with refractory focal XXXX - Looking beyond unilateral @entity5 .

answer: @entity2


abstract: BACKGROUND: SIAscopy (Spectrophotometric Intracutaneous Analysis) enables non-invasive analysis of the skin. OBJECTIVE: We wanted to determine whether SIAscopy is able to detect and differentiate the skin chromophores melanin, collagen and haemoglobin and the influence of immunosuppressive drugs and other known risk factors for @entity1 ( @entity1 ). METHODS: Volunteers and @entity0 were measured by SIAscopy at six spots on sun-exposed and two spots on sun-protected skin. Measurements were transformed by SIAmetrics into arbitrary units and statistically analysed. RESULTS: Melanin was shown to be higher with age (+1.73759  a.u.; P  <  0.0001), sun exposure (+47.03998 a.u.; P  <  0.0001), immunosuppression (+10.48526  a.u.; P  <  0.0001) and lower in males (-26.50952 a.u.; P  <  0.0001). Collagen was lower with increasing age (-0.29162 a.u.; P  <  0.0001) and sun exposure (-6.85586  a.u.; P  <  0.0001) but higher with male sex (+8.34251  a.u.; P  <  0.0001) and immunosuppression (+5.79171  a.u.; P  =  0.0001). Haemoglobin was lower with increasing age (-0.23833  a.u.; P  =  0.0005), but higher with male sex (+18.51976  a.u.; P  <  0.0001) and sun exposure (+13.74523  a.u.; P  <  0.0001). Haemoglobin content was not associated to immunosuppression. CONCLUSION: Our results encourage the use of SIAscopy as a tool to better gauge an individual @entity0 's @entity1 risk factors. Further studies should help to better delineate SIAscopy as a prognostic tool.

title: Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised XXXX .

answer: @entity0


abstract: BACKGROUND: @entity3 combined with an extremely @entity1 remains as a complex condition to deal with. And the emergence of microincision vitrectomy surgery (MIVS) system may provide an ideal option for the treatment of that. We report a clinical study of surgical outcomes of 23-gauge transconjunctival pars plana vitrectomy ( @entity5 ) combined with lensectomy in the treatment of @entity4 with extremely shallow anterior chamber and @entity1 . METHODS: Prospective, nonrandomized and noncomparative case series study. Consecutive @entity0 with @entity3 , extremely shallow anterior chamber and @entity1 were recruited to have combined surgeries of 23-gauge transconjunctival pars plana vitrectomy and lensectomy. The main outcomes were best corrected visual acuity (BCVA), intraocular pressure (IOP), @entity6 ( @entity6 ), number of anti- @entity3 medications and surgery-associated complications. RESULTS: Seventeen consecutive @entity0 with @entity3 , extremely shallow anterior chamber and @entity1 were recruited. The mean follow-up was 21.2        8.8  months. Postoperatively, there was no significant improvement of BCVA (P   =   0.25). The mean intraocular (IOP) decreased significantly from 43.14        6.53  mmHg to 17.29        1.80  mmHg (P   <   0.001), and the mean depth of anterior chamber increased significantly from 0.507        0.212  mm to 3.080        0.313  mm (P   <   0.001). The mean number of anti- @entity3 medications decreased from 4.1        0.8 to 0.6        0.8 (P   <   0.001). No severe vision-threatening intra- or post-operative complications occurred. CONCLUSIONS: @entity3 with an extremely shallow anterior chamber and @entity1 can be managed well with the combined surgeries of 23-gauge pars plana vitrectomy and lensectomy. The surgical procedure is an effective and safe method to resolve the @entity2 and deepen the anterior chamber.

title: Surgical outcomes of 23-gauge transconjunctival pars plana vitrectomy combined with lensectomy for @entity4 with extremely shallow anterior chamber and XXXX .

answer: @entity1


abstract: Snake venoms are mixtures of bioactive proteins and peptides that exhibit diverse biochemical activities. This wide array of pharmacologies associated with snake venoms has made them attractive sources for research into potentially novel therapeutics, and several venom-derived drugs are now in use. In the current study we performed a broad screen of a variety of venoms (61 taxa) from the major @entity7 families (Viperidae, Elapidae and "Colubridae") in order to examine cytotoxic effects toward MCF-7 @entity0 cells and A-375 @entity6 cells. @entity3 cell viability assays of @entity1 cells incubated with crude venoms revealed that most venoms showed significant @entity4 . We further investigated venom from the Red-bellied Blacksnake (Pseudechis porphyriacus); venom was fractionated by ion exchange fast protein liquid chromatography and several cytotoxic components were isolated. @entity5 -PAGE and MALDI-TOF mass spectrometry were used to identify the compounds in this venom responsible for the cytotoxic effects. In general, viper venoms were potently cytotoxic, with MCF-7 cells showing greater sensitivity, while elapid and colubrid venoms were much less toxic; notable exceptions included the elapid genera Micrurus, Naja and Pseudechis, which were quite cytotoxic to both cell lines. However, venoms with the most potent @entity4 were often not those with low @entity2 LD50s, including some dangerously venomous viperids and Australian elapids. This study confirmed that many venoms contain cytotoxic compounds, including catalytic @entity8 , and several venoms also showed significant differential @entity4 toward the two @entity1 cell lines. Our results indicate that several previously uncharacterized venoms could contain promising lead compounds for drug development.

title: Evaluation of cytotoxic activities of snake XXXX (A-375) cell lines.

answer: @entity0


abstract: OBJECTIVES: To assess the effectiveness of continuous @entity5 acupressure as an adjunct to antiemetic drug therapy in the prevention and control of @entity1 and @entity2 in the first 24h after @entity3 ( @entity3 ). DESIGN: Partially randomised, partially blinded placebo-controlled, exploratory clinical study. SETTING: Coronary Care Unit, Torbay Hospital, Torquay, Devon. @entity0 : A total of 301 consecutive @entity0 (205 males, 96 females) admitted following acute @entity3 . INTERVENTION: The first 125 @entity0 recruited received no additional intervention. Subsequent @entity0 were randomised to receive either continuous @entity5 acupressure or placebo acupressure. OUTCOME MEASURES: (1) Incidence of @entity3 , (2) severity of symptoms, (3) use of antiemetic drugs, over 24h. RESULTS: There were no significant differences between the groups for the whole 24-h treatment period. However, the @entity5 acupressure group experienced significantly lower incidence of @entity4 during the last 20h (18%), compared with the placebo (32%) or control (43%) groups (P<0.05). The severity of symptoms and the need for antiemetic drugs were also reduced in the acupressure group, but these differences were not statistically significant. CONCLUSIONS: Continuous 24-h @entity5 acupressure therapy as an adjunct to standard antiemetic medication for @entity3 is feasible and is well accepted and tolerated by @entity0 . In view of its benefits, further studies are worthwhile using earlier onset of treatment.

title: Continuous @entity5 wristband acupressure for relief of @entity1 and XXXX associated with @entity3 : a partially randomised, placebo-controlled trial.

answer: @entity2


abstract: Chronic high frequency (130 Hz) stimulation (HFS) of the thalamic target @entity8 , first used in our group in 1987 as a treatment of @entity5 of various origins, has been used over the last ten years in 137 @entity0 . Since 1993, this method has been extended to two other targets (subthalamic nucleus (STN): 137 @entity0 and the medial pallidum ( @entity10 ): 12 @entity0 ), based on recent experimental data in @entity2 and monkeys. STN appears to be a target of major interest, able to control the three cardinal symptoms and to allow the decrease or suppression of levodopa treatment, which then also suppresses levodopa induced @entity6 . The stereotactic technique is based on the determination of the target using ventriculography, MRI and electrophysiology, with both microrecording of single neuron activity and microstimulation inducing therapeutic symptom suppression and side effects. Chronic electrodes are then placed bilaterally at the best physiologically defined location and then connected to implantable stimulators (either 2 Itrel II or the new double channel Kinetra), operated at 130-185 Hz, 60 ms pulse width, 2.5 to 3.5 volts. There was no operative mortality and permanent morbidity was observed in 3 @entity0 . The mechanisms of action of HFS are not fully understood, but are definitely related to high frequency and are probably different depending on the target. Inhibition of cellular activity or of neural network functions could be induced, by jamming of a retroactive loop for @entity5 , or by shutdown of neurotransmitter release in STN. Mechanisms within an individual target are also probably different for @entity5 or for other symptom alleviation. All cardinal symptoms are alleviated from @entity5 to @entity6 and @entity7 . This strong improvement allows the decrease of the drug dosage to approximately 30% of the preoperative level, which suppresses the levodopa-induced @entity6 . The off period @entity9 are also suppressed as well as freezings and falls. The effects remain stable over more than 5 years and in the same period, the off stimulation-off medication UPDRS remains stable and does not increase at the usual rate The low rate of permanent complications, the minor side effects and their immediate reversibility, the possibility of bilateral implantation in one session and the long-term persistence of symptom relief are strong arguments which support chronic HFS of STN as the method of choice when a surgical procedure is indicated for the treatment of @entity3 and even more when a bilateral procedure is necessary. Recent data show that STN stimulation could be useful in the treatment of @entity9 as well as some forms of @entity4 . It is therefore possible that DBS in STN as well as in other targets could become a potent therapeutic tool in the near future for @entity1 .

title: Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in @entity3 . Extension to new indications such as @entity9 and XXXX .

answer: @entity4


abstract: BACKGROUND/PURPOSE: Despite frequent use of percutaneous endoscopic gastrostomy ( @entity2 ) for enteral feeding, the relationship between it and @entity1 ( @entity1 ) remains an incompletely answered question. We conducted this study to compare the @entity1 between the same @entity0 fed with a nasogastric (NG) tube and later with a @entity2 tube. METHODS: We enrolled 15 @entity0 who had received NG tube feeding for > 6 months and were about to receive @entity2 tube insertion. We used Ponsky's pull method with 24 Fr feeding tubes. They received two @entity1 scans, one just before @entity2 tube insertion and another 1 week after insertion. We drew regions of interest of radioactivity in the esophagus and stomach manually. The ratios of radioactivity of the region of interest in the esophagus over the stomach ( @entity1 ratio) were calculated to evaluate the severity of @entity1 and compared. RESULTS: The @entity1 ratios of these @entity0 were all small and <3% except one that was 4.7% in one @entity0 before @entity2 tube insertion. There was a small but substantial decrease (65% risk reduction) in @entity1 ratio after @entity2 tube insertion. After arcsine transformation, the difference in the transformed data between @entity0 fed with an NG tube and after @entity2 tube insertion was significant (t= 2.46, p = 0.028), and was lower after @entity2 tube insertion. CONCLUSION: Our study demonstrates by scintigraphy a small but significant reduction of @entity1 after shifting from NG to @entity2 tube feeding.

title: Changes in XXXX in @entity0 with nasogastric tube followed by percutaneous endoscopic gastrostomy.

answer: @entity1


abstract: In our previous studies, we established a lymphogenous metastatic @entity4 @entity3 model using orthotopic implantation of @entity0 @entity1 cell lines. However, the lymphogenous metastatic potential of each cell line in our models does not reflect that of a @entity2 . In this study, we made orthotopic implanted models using primary cultured cells from surgically-resected @entity1 tissues. Tissues of 5 @entity0 with @entity5 ( @entity5 ) were applied to a primary culture method using a collagen gel coated flask. Suspensions of 2.0x10(4) @entity2 cells were injected into the left lung of @entity4 @entity3 . We could maintain primary culture cells from 2 (FM205 and FT821 cells) of 5 @entity1 , and made orthotopically implanted @entity4 @entity3 models. The size of both @entity2 in implanted sites of the lung increased with time. The FM205 cells microscopically were metastasized to the mediastinum by 4 weeks after implantation and macroscopically metastasized by 16 weeks. The FT821 cells were microscopically metastasized to the mediastinum by 4 weeks after implantation and macroscopically metastasized by 6 weeks. The lymphogenous metastatic potential of these primary culture cells was similar to that of clinical @entity2 . As the lymphogenous metastatic potential of this model reflects that of the clinical @entity2 , it is useful for elucidating the mechanism of lymphogenous metastasis and selecting anticancer drugs suitable for an individual @entity0 .

title: Establishment of @entity0 -like @entity4 XXXX model by orthotopically implanting primary cultured cells from surgically-resected @entity1 tissues.

answer: @entity3


abstract: INTRODUCTION: Bladder augmentation is widely used to treat otherwise unmanageable urinary incontinence. However, it is associated with a large number of complications, of which @entity1 formation is the most severe. @entity8 proteins and MUC genes are linked, among others, to @entity6 . OBJECTIVE: To investigate histological alterations as well as changes in expression of @entity7 and @entity9 genes and proteins following different types of urinary bladder augmentation or substitution performed in @entity0 and adolescents. @entity0 AND METHODS: Between 1988 and 2013, 91 @entity0 underwent urinary bladder augmentation or substitution at the study institute. @entity0 were included on whom cystoplasty had been performed 4 years previously or earlier, and could have been followed-up prospectively. Thus, 54 @entity0 were involved in the study. In eight @entity0 gastrocystoplasty was performed, in 17 @entity0 ileocystoplasty, and in 22 @entity0 colocystoplasty. Seven @entity0 underwent bladder substitution using a colonic-segment. Biopsies were taken via cystoscopy from the native bladder, from the @entity3 used for augmentation, and from the anastomotic line between these two. One part of the samples was fixed in @entity4 for routine histological processing. The other part of the biopsies was embedded into OCT medium, then cryosectioned and fluorescently double-immunostained for @entity7 and @entity9 proteins. Samples from the microscopically @entity2 and from the 15-year-old or older biopsies were processed by laser capture microdissection, and then real-time PCR was done. Data were statistically analyzed by ANOVA and ordinary least squares regression tests. RESULTS: One @entity5 was found in a female @entity0 , 11 years after colocystoplasty. There were no significant changes in the level of @entity7 and @entity9 proteins and gene expression in the urothelium and in the @entity3 used for augmentation following ileocystoplasty and gastrocystoplasty. Significant increase in @entity7 and decrease in @entity9 protein levels were detected following colocystoplasty in the large bowel segment used for augmentation, both with qualitative and quantitative methods (p  <  0.05) (Figure). The uroepithelium showed no significant change. RT-PCR revealed progressive increase in @entity7 gene expression and decrease in @entity9 gene expression after colocystoplasty in the course of time. It also showed highly increased @entity7 gene expression and decreased @entity9 gene expression in the samples of @entity0 . CONCLUSIONS: Alterations in gene expression of @entity7 and @entity9 might serve as promising markers for early detection of histological changes after colocystoplasty.

title: Long-term histological and @entity8 alterations in the neobladder mucosa following urinary bladder augmentation or substitution with XXXX .

answer: @entity3


abstract: BACKGROUND: Many institutions recommend a stepwise approach to intradermal testing for venom @entity1 . This is costly and uncomfortable for the @entity0 . The rationale for this approach is the risk of potential adverse reactions to testing with the maximal dose alone. OBJECTIVE: To evaluate the safety of a single-step approach to venom @entity1 testing. METHODS: The authors retrospectively reviewed the charts of 300 consecutive @entity0 with suspected hymenoptera venom @entity1 based on history who underwent venom @entity1 testing in a single allergist's clinic where a single-step protocol had been adopted. All @entity0 had positive skin test reaction to at least 1 hymenoptera venom. Charts were reviewed for testing protocol used, results of testing, and reported immediate and delayed adverse reactions to testing. RESULTS: All @entity0 underwent testing with an identical single-step protocol with an intradermal dose of 0.02 mL of a 1.0- g/mL concentration of each of the 5 commercially available vespid and @entity2 venoms. Only 1 @entity0 reported an adverse reaction to testing, which was delayed until the morning after his visit. There were no immediate adverse reactions. The @entity0 who had the delayed reaction was successfully started on venom immunotherapy subsequent to his reaction. CONCLUSION: A single-step venom @entity1 intradermal testing protocol with a 1.0- g/mL concentration of commercially available extracts is a safe option, which, if adopted into practice, could lead to more streamlined care for @entity0 and cost savings for the medical system.

title: XXXX testing: is a graded approach necessary?

answer: @entity1