abstract: In an analysis of a large single-institution experience in the surgical management of @entity6 ( @entity6 ) and @entity7 , the authors present the effect of @entity6 characteristics on survival, and aim to identify potential preoperative variables predictive of intraoperative complexity with regard to estimated @entity2 , transfusion volume, surgical time, length of stay, and @entity3 rates. Age, American Society of Anesthesiologists score, Charlson Comorbidity Index, preoperative @entity4 , preoperative @entity5 , and IVC wall invasion were significantly related to complication rates. INTRODUCTION: Preoperative laboratory values are commonly used as markers of health and potential disease burden, however, their effect on perioperative complexity has not previously been assessed. The authors aimed to evaluate the effect of @entity6 and @entity7 characteristics on @entity1 -specific survival (CSS), and identify potential preoperative variables predictive of intraoperative complexity. MATERIALS AND METHODS: In a retrospective chart review we identified 144 @entity0 who underwent nephrectomy and IVC thrombectomy. Univariate and multivariate analyses were used to assess the effect of disease characteristics on CSS and @entity3 . Linear regression analysis was used to determine the association between preoperative laboratory values and intraoperative complexity characterized by estimated @entity2 (EBL), transfusion volume (TV), operative time, and length of hospital stay (LOS). RESULTS: Analysis of intraoperative complexity revealed a significant correlation between preoperative @entity5 ( @entity8 ) and EBL (P = .022), TV (P = .041), and LOS (P = .005), and preoperative hemoglobin (Hgb) was associated with increased EBL (P < .001) and TV (P < .001). Multivariate analyses showed a significant relationship between overall complication rates and preoperative @entity4 ( @entity9 ; P = .012), American Society of Anesthesiologists (ASA) score (P = .003), and IVC wall invasion (P = .005), and a significant association between major complications and preoperative @entity9 (P = .011), preoperative @entity8 (P = .041), age (P = .050), and Charlson Comorbidity Index (CCI; P = .002). CONCLUSION: With regard to intraoperative @entity3 , preoperative @entity8 and Hgb were significantly associated with increased EBL, TV, and LOS, and ASA score, preoperative @entity9 , preoperative @entity8 , IVC wall invasion, age, and CCI were found to have significant relationships with complication rates.

title: Predictors of @entity3 in XXXX Who Undergo Radical Nephrectomy and IVC Thrombectomy: A Large Contemporary Tertiary Center Analysis.

answer: @entity0


abstract: Developmental changes in the synthesis of @entity2 ( @entity3 ) were investigated in @entity0 hippocampus and frontal cortex. Particular reference was made to the conversion, into @entity3 , of the @entity4 accumulated by high-affinity uptake as defined using 1 microM @entity7 (HC-3). Using solutions containing 11.1 mM @entity1 , conversions were respectively 31 and 55%, in fine slices from 4-8-day-olds. Free @entity4 accounted very largely for the remainder of the @entity4 accumulated. In samples from adults, @entity3 accounted for 80% of the uptake. The inefficient conversions (into @entity3 ) in immature brain were not the result of a requirement for @entity5 bodies as the source of @entity6 ( @entity6 ). Greater rates of release of newly synthesised @entity3 , than in mature samples, were not responsible, neither were greater cholinesterase activities. The stimulation of high-affinity @entity4 uptake, caused by prior depolarisation of the tissues using K+, also increased during development from 78 to 238% with hippocampus and from 49 to 170% with frontal cortex. Furthermore, prior depolarisation increased the efficiency with which @entity4 , accumulated by high-affinity uptake, was converted into @entity3 . At all stages of development 80% of the additional @entity4 accumulated, after depolarisation, was converted into @entity3 . It is concluded that the specificity of HC-3-sensitive uptake is incomplete in immature brain, i.e. high-affinity @entity4 uptake is not exclusively into cholinergic neurones. The cholinergic neuronal compartment becomes more prominent during development so that the specificity is complete in mature brain.(ABSTRACT TRUNCATED AT 250 WORDS)

title: High-affinity uptake of @entity4 , a marker for cholinergic nerve terminals, is not specific in developing XXXX brain.

answer: @entity0


abstract: BACKGROUND: The authors investigated the maximum tolerated dose (MTD) and dose limiting @entity2 (DLT) associated with the addition of a biomodulating dose of @entity1 to an established regimen of @entity6 and @entity5 as part of a program to explore the potential of low-dose @entity1 to modulate the activity of alkylating agents. METHODS: A Phase I trial was carried out in a population of @entity0 with @entity3 for whom no standard therapy was available. Doses of @entity6 and @entity5 were held fixed at 2 g/m(2) for 4 days and 20 mg/m(2) for 3 days, respectively. @entity1 was given on Day 2 and Day 4 at doses of 90 mg/m(2), 150 mg/m(2), and 200 mg/m(2) per dose. RESULTS: A total of 18 @entity0 received 53 courses of therapy. Myelosuppression was dose limiting. Nonhematologic @entity2 also was significant, with 10 of 18 @entity0 experiencing @entity2 of Grade 3 or greater. For previously untreated @entity0 with an intact performance status, the MTD for @entity1 in this context was at least 150 mg/m(2) per dose. According to an intent-to-treat analysis, 11 of 18 @entity0 demonstrated a clinically significant response to this regimen. CONCLUSIONS: The regimen of @entity6 and @entity5 with the addition of @entity1 was significantly toxic but has promising activity. Based on the observed activity and the generally reversible nature of the @entity2 , the authors have initiated a Phase II trial of this regimen in @entity0 with untreated, metastatic @entity4 .

title: @entity1 modulation of alkylator therapy: a phase I trial of escalating @entity1 added to fixed doses of XXXX and @entity5 .

answer: @entity6


abstract: PURPOSE: Prior studies suggest that specialist care associates with improved health-related quality of life (HRQL) in @entity5 @entity0 . However, there are limited studies focused on differences in HRQL among subspecialties. The aim of this study was to assess the differences in HRQL between adult @entity5 @entity0 treated in pneumology or @entity4 practices, and to estimate to what extent the differences in HRQL can be explained by sociodemographic, clinical or psychological characteristics of @entity0 from each specialty. METHODS: We recruited adult @entity5 outpatients from @entity4 and pneumology practices. Information on sociodemographic, clinical and psychological characteristics was collected, and HRQL was assessed with generic and disease-specific questionnaires. HRQL was compared between groups adjusting for sociodemographic, clinical and psychological characteristics. RESULTS: A total of 287 @entity5 @entity0 participated in the study (105 from pneumology and 182 from @entity4 ). @entity0 treated by pneumologists reported significantly poorer HRQL in physical dimensions of generic questionnaire and all dimensions of disease-specific questionnaire. Pneumology @entity0 were older (p  <  .001) and had a lower education level (p  <  .001); a higher number of @entity0 were in a non-active employment situation (p  =  .003) and had worse pulmonary function (p  <  .001), longer duration of disease (p  =  .020), higher prevalence of @entity1 (p  <  .001) and uncontrolled @entity3 (p  <  .001), and a higher rate of previous absenteeism (p  =  .001). @entity2 and the use of cognitive avoidance coping were also higher among pneumology @entity0 (p  =  .050 and p  =  .022, respectively). There were not significant differences in HRQL between pneumology and @entity4 @entity0 after adjustment for these sociodemographic, clinical and psychological characteristics. CONCLUSIONS: @entity5 @entity0 treated by pneumologists reported poorer HRQL than @entity0 treated by allergists, but this outcome is attributed to differences in several sociodemographic, clinical and psychological characteristics between the two groups of @entity0 .

title: Quality of life in adults with @entity3 treated in XXXX and pneumology subspecialties: relationship with sociodemographic, clinical and psychological variables.

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ) is the major limitation of allogeneic haemopoietic stem-cell transplantation (HSCT), for which no approved treatments are available. Use of mesenchymal stromal cells (MSCs) has become standard practice in some European countries, but controversy exists for their benefit. The aim of this meta-analysis was to analyse available evidence for the benefit of MSC treatments in @entity1 -resistant acute @entity2 . METHODS: We did a systematic review and meta-analysis to assess response to and survival after MSC treatment in @entity0 with @entity1 -refractory acute @entity2 . We searched MEDLINE, Embase, Ovid, and Cochrane Central databases for published studies, and we used ClinicalTrials.gov and other websites to find unpublished studies and conference abstracts. We included prospective and retrospective studies in which MSCs were administered to @entity0 with @entity1 -refractory acute @entity2 . Data were extracted independently by two investigators based on strict selection criteria. A random-effects model was used to pool outcomes across studies because of anticipated heterogeneity. Our primary outcome was survival at 6 months from the first infusion of MSCs. FINDINGS: We identified 628 citations with our search, of which 610 were excluded after review and a further five did not contain pertinent data. Thus, our meta-analysis included 13 non-randomised studies at moderate risk of bias, comprising a total of 336 @entity0 . Six studies provided data for the primary outcome analysis (119 @entity0 ). Survival at 6 months after MSC treatment was 63% (95% CI 50-74; I(2)=41%). Survival did not differ with respect to age, MSC culture medium, or dose of MSCs delivered. INTERPRETATION: Available evidence suggests that infusion of MSCs could be an acceptable treatment for @entity0 with @entity1 -refractory acute @entity2 . Randomised clinical trials are needed urgently to assess different treatment modalities for @entity1 -refractory acute @entity2 . FUNDING: None.

title: Survival after mesenchymal stromal cell therapy in XXXX -refractory acute graft-versus-host disease: systematic review and meta-analysis.

answer: @entity1


abstract: All forms of life maintain a reducing environment (homeostasis) within their cells. Perturbations in the normal redox state can lead to an oxidative environment which has deleterious effects, especially in health. In biological systems, metabolic activities are dependent mainly on mitochondrial oxidative phosphorylation, a metabolic pathway that uses energy released by the oxidation of nutrients to produce @entity3 . In the process of oxidative phosphorylation, electrons are transferred from electron donors to electron acceptors such as @entity0 in redox reactions and often results to the generation of reactive species. Reactive @entity0 species consist of a class of radical and non-radical @entity0 derivatives. The imbalance between the reactive @entity0 species and antioxidant defence systems leads to oxidative burden and hence, damage biological molecules. Antioxidants help to prevent or fix the deleterious effects of reactive species. @entity2 is an important element in biological systems. This atom is usually integrated into proteins as the redox-active @entity1 residue and in molecules such as @entity4 , @entity5 and @entity6 which are vital antioxidant molecules and are therefore essential for life. This review covers the role of @entity2 containing antioxidant systems in oxidative environments.

title: Potential Role of XXXX -Containing Antioxidant Systems in Highly Oxidative Environments.

answer: @entity2


abstract: The infectivity and pathogenicity of the penaeid shrimp virus, Baculovirus penaei (BP), is influenced by the stage of viral development. This study consisted of a preliminary experiment which showed that nonocculuded virus administered per os is infective, followed by two infectivity experiments. In the first phase of each infectivity experiment, mysis stage larvae of @entity1 were inoculated with BP and samples of infected tissue were collected at various times postinoculation (p.i.). These samples were then used to inoculate either mysis or postlarval stage @entity1 in the second phase of each experiment. Viral inocula prepared from patently infected tissues consistently produced @entity0 in both mysis and postlarval stage shrimp. Inocula prepared from prepatently infected tissue collected 12-18 h p.i. produced @entity0 in some, but not all replicate cultures, while inocula prepared from tissues collected earlier than 12 h p.i. were not infective. Viral development in mysis stage larvae was substantially delayed and the mortality was significantly lower when the viral inocula were prepared from prepatently compared to patently infected tissues. BP appears to be most pathogenic to larvae that have been exposed to inocula prepared from tissues that had recently developed a high prevalence of patent @entity0 or about 72 h p.i.

title: Infectivity and pathogenicity of Baculovirus penaei (BP) in cultured larval and postlarval @entity1 , XXXX , related to the stage of viral development.

answer: @entity1


abstract: @entity2 of @entity0 during cardiac operations are closely associated with affections of the carotid arteries. The relationship of @entity1 to these findings was not investigated so far. During the period between July 1 and Dec. 31 2000 the authors examined sonographically 127 @entity0 indicated for aortocoronary bypass on account of affection of three arteries. @entity1 was present in 44 @entity0 . A significant @entity5 was detected in 4 (5%) without @entity1 and in 5 (11%) @entity0 with @entity1 (p < 0.05), moreover in two @entity0 with @entity1 was found. An insignificant @entity5 (up to 70% was found in 3 (3%) of the @entity0 without @entity1 and in 3 (7%) @entity0 with @entity1 (p < 0.05). The thickness of the intima and media (IMT) was in @entity0 with @entity1 insignificantly greater (0.76 vs. 0.89 mm, NS). The mean index of echogenicity of plaques was in @entity1 @entity0 also insignificantly greater (2.1 vs. 2.9 NS). @entity4 greater than 2 mm were more frequent in @entity1 (7.8% vs. 8 (18%), p < 0.05). A significantly more frequent finding of @entity3 or larger plaques was proved in @entity0 with a history of CMP. Sonographic findings on the vertebral arteries were not associated with the presence of @entity1 . CONCLUSION: Carotid sonography in @entity0 of three arteries reveals in @entity1 @entity0 and in those with a history of CMP more frequent significant @entity5 and the presence of major @entity4 .

title: [Sonography findings in the carotid arteries in XXXX before aortocoronary bypass].

answer: @entity1


abstract: In a previous prospective study, @entity2 was identified as the causative agent in 148 (42.8%) of 346 adult @entity0 hospitalized over the course of one year with @entity3 ( @entity3 ) in the Soroka Medical Center, Beer-Sheva, Israel. The present study characterizes those cases in which @entity2 was the only pathogen and those in which additional etiological agents were identified. Pneumococcal @entity3 was diagnosed by standard blood cultures or positive serological tests by one of two laboratory methods. In 100 (67.6%) @entity0 , at least one other etiological agent of @entity3 was identified in addition to @entity2 . Compared with @entity0 who were not infected by @entity2 , @entity0 with @entity2 @entity3 were older and had a higher rate of comorbidity (39.5% vs. 29.8%). @entity2 @entity3 had a more severe clinical course and a higher mortality rate, especially when @entity2 was the only pathogen. @entity3 due to @entity2 only was more similar in its clinical manifestations to classic @entity4 . When an additional etiological agent was identified, the clinical characteristics could not be distinguished from those of @entity1 . It is concluded that @entity2 remains the principal cause of @entity3 in this region. The frequency of additional etiological agents of @entity3 and the difficulty in differentiating clinically between cases due to @entity2 only and those due to @entity2 plus other organisms necessitates initial empirical treatment that covers @entity2 as well as other causative agents of @entity1 .

title: Pneumococcal XXXX in 148 hospitalized adult @entity0 .

answer: @entity3


abstract: UNASSIGNED: 187 Background: Distress is a multifactorial, emotional experience that may interfere with @entity1 ' ability to cope with @entity2 and its treatment. Recognizing and managing distress may benefit @entity1 . The Commission on Cancer requires implementation of Standard 3.2, Psychosocial Distress Screening in 2015 and integrating distress intervention in @entity2 care. This study evaluates @entity1 ' perception on benefits in this regard. METHODS: @entity1 were screened at least once at a pivotal medical visit using a questionnaire that included various aspects of stress. NCCN's Psychosocial Distress Screening Tool was used to measure seriousness of distress. @entity1 marked their distress level on a scale of 1 to 10. A threshold of 5 was set as a trigger point to start addressing distress. RESULTS: Answers from 311 @entity2 @entity1 (male 61%; female 39%) were evaluated since January 2015. A majority of @entity1 had @entity0 (29%), followed by lung (18%), GI (18%), and hematological (12%) @entity2 . The mean distress score was 3.72 (male 3.14; female 3.97). 131 @entity1 had a score above five. Age group, 40-49 years had a higher distress (4.79) compared to others. @entity5 (1%) had the highest mean score 7.33 followed by @entity3 (4%) with 5.67. In most @entity1 , @entity4 about @entity2 and its treatment was the cause of distress. However, they did not want any additional psychosocial intervention except for talking to their oncologist and primary physician. The distress of some @entity1 was family related and they were unsure of the help needed. Two @entity1 refused screening stating the questions were intrusive. CONCLUSIONS: Coordinated psychosocial care may benefit @entity2 @entity1 with significant distress. NCCN tool helps to assess the severity of @entity1 ' distress and to determine the need for intervention. The results (mean score of 3.72) suggest most @entity2 @entity1 need no major intervention or special psychosocial counseling other than discussing with their physician and family, which is done routinely in most oncology practices. However, when stress is expressed, this tool does help the treating physicians to determine the specific area and degree of stress, to focus on the type of help needed for the @entity1 , and to channel resources appropriately.

title: Psychosocial distress screening in XXXX care.

answer: @entity2


abstract: INTRODUCTION: Abnormal repolarization is one of the acknowledged mechanisms leading to malignant @entity2 . We used a novel magnetocardiographic technique to investigate the role of inhomogeneous repolarization in @entity0 with @entity1 prone to sustained @entity2 . METHODS AND RESULTS: Forty-nine @entity1 @entity0 were studied, 18 with a history of sustained @entity4 (n = 6) or @entity5 (n = 12) and 31 with no @entity2 . The magnetocardiogram was registered and @entity3 apex and @entity3 end intervals were determined by a computer algorithm. Inhomogeneity of repolarization was characterized with indices describing @entity3 apex and @entity3 end dispersion, and T wave end duration. In addition, time-domain late fields of the QRS complex in magnetocardiography and @entity3 dispersion in 12-lead ECG were determined. T wave end was longer in the @entity2 group in @entity0 with sinus rhythm (87 +/- 15 msec vs 73 +/- 12 msec; P = 0.005) and in those not having @entity6 . Magnetocardiographic late fields of the QRS complex were not different between groups. @entity3 apex and end dispersion on magnetocardiography or 12-lead ECG showed no difference. CONCLUSION: Prolongation of the end part of the T wave revealed by magnetocardiography is related to malignant @entity2 in @entity1 . The results suggest that abnormal repolarization rather than delayed conduction underlies the @entity2 in this disease.

title: Repolarization abnormalities detected by magnetocardiography in XXXX with @entity1 and @entity2 .

answer: @entity0


abstract: The in vivo nitrosation capacity of third-instar larvae of @entity0 was assessed using the wing somatic mutation and recombination test (SMART). Larvate derived from two different crosses, the standard cross (ST) and the high bioactivation cross (HB) both involving the recessive wing cell markers multiple wing hairs (mwh) and flare (flr3), were used. The HB cross is characterised by an increased @entity7 -dependent bioactivation capacity for promutagens and procarcinogens. The larvae were treated either with @entity6 , @entity4 or its combination. @entity3 was used as a positive control. The wings of the resulting flies were analysed for the occurrence of mutant spots produced by various types of mutational events or by mitotic recombination. @entity6 is negative in the ST and the HB cross, whereas @entity4 is weakly genotoxic in both crosses. However, the combination of both compounds produces highly increased frequencies of mutations and recombinations predominantly in the HB cross. The genotoxic effects produced by the combined treatments were considerably increased when mashed @entity2 or an agar- @entity1 medium were used for the treatment instead of the standard instant medium. Treatment of larvae with the mixture resulting from the in vitro reaction of nitrosation precursors also resulted in high frequencies of induced spots comparable to those recorded with the potent genotoxin @entity3 . Further experiments showed that the genotoxic effect resulting from the in vivo exposure to nitrosation precursors can be reduced by co-treatment with @entity5 , a known nitrosation inhibitor. The present study demonstrates that the wing spot test is well suited for the determination of genotoxicity produced by in vivo nitrosation processes and for the study of their modulation by individual compounds or dietary complex mixtures.

title: Analysis of the in vivo nitrosation capacity of the larvae used in the wing somatic mutation and recombination test of XXXX .

answer: @entity0


abstract: Chemotherapy sensitivity has been identified as an important prognostic factor in @entity1 ( @entity1 ) for @entity7 ( @entity7 ). However, the effect of uniform salvage chemotherapy before @entity1 has not been studied prospectively. We examined whether the response to prospectively administered uniform salvage therapy ( @entity8 , @entity2 , @entity6 , @entity4 , @entity3 , and @entity9 ) influenced the subsequent outcome of @entity1 in 28 @entity0 with relapsed or @entity7 . After @entity1 , @entity5 ( @entity5 ) at 36 months is 49%, whereas @entity5 ( @entity5 ) is 32%. In Cox model analyses, the response to chemotherapy was the best predictor of @entity5 (P = .0006) and @entity5 (P = .0006) after @entity1 . Differentiating stable disease from progressive disease after salvage chemotherapy strengthened the association with survival. Among chemotherapy-sensitive @entity0 , the median @entity5 and @entity5 have not been reached. In @entity0 with stable disease, @entity5 and @entity5 at 24 months are 50% and 25%, respectively. In contrast, only 1 @entity0 with progressive disease during salvage therapy survived longer than 12 months. These prospective data confirm the favorable prognosis for chemotherapy-sensitive @entity7 after @entity1 and suggest that chemotherapy resistance is not an absolute contraindication to @entity1 for @entity7 @entity0 with stable disease during salvage therapy.

title: Efficacy of @entity1 in chemotherapy-refractory XXXX .

answer: @entity7


abstract: PURPOSE: The goal of this study was to determine if a @entity8 powder intradermal system designed to provide cutaneous @entity6 is efficacious, safe, and tolerable for pediatric subjects compared with a sham placebo system. METHODS: COMFORT-004, A Phase III, Randomized, Double-Blind, Placebo-Controlled Study to Confirm the Effectiveness and Safety of ALGRX 3268 in Pediatric Subjects, was a single-dose, parallel group study of @entity0 undergoing venipuncture or peripheral venous cannulation at the antecubital fossa or back of the hand. Included were subjects (3-18 years) in 3 age groups: 3-7, 8-12, and 13-18 years. Excluded were those with recent similar procedures or with implantable devices or skin pathologies at the anatomical site, insufficient @entity1 , or @entity5 to local anesthetics or adhesives. Subjects were randomized to receive the needle-free powder @entity7 delivery system (active system, 0.5 mg of @entity7 /21    1 bar of pressure [n = 269]) or sham placebo (n = 266) 1-3 minutes before venipuncture or peripheral venous cannulation. Analgesic efficacy was assessed @entity0 self-report of @entity2 (Wong-Baker FACES Pain Rating Scale [3-18 years] and visual analog scale [VAS; 8-18 years]) and parental observational VAS. Safety assessments included adverse events (AEs) and relationship to study treatment. Skin signs and symptoms were graded numerically. Wong-Baker FACES scores, VAS, and parental VAS were analyzed by using an ANOVA model. Responder ratings and success rates were compared by using a Cochran-Mantel-Haenszel test stratified according to center, age group, and body site. FINDINGS: The active system group had significantly (P = 0.0022) less @entity2 compared with the sham placebo in all age groups combined according to the modified Wong-Baker FACES scale. Secondary efficacy analyses found that the active system resulted in less @entity2 as assessed by subjects' VAS @entity2 assessments aged 8-18 years (P = 0.1856), responder analysis (P = 0.054), and parents' VAS assessments (P = 0.002). Venous procedures were successful in 95.5% and 96.2% of the active system and sham placebo groups, respectively. Treatment-emergent AEs, most commonly @entity3 and/or emesis, were not significant between groups. There were no serious AEs. The active system group had significantly more minor erythema and @entity4 /petechiae. IMPLICATIONS: The needle-free powder @entity7 delivery system was well tolerated and produced superior @entity6 compared with sham placebo when administered 1-3 minutes before pediatric venipuncture or peripheral venous cannulation. Treatment-related AEs occurred primarily at the administration site and were infrequent, generally mild, and resolved without sequelae. ClinicalTrials.gov identifier: NCT00140088.

title: Safety and Efficacy of a Needle-free Powder XXXX Delivery System in Pediatric @entity0 Undergoing Venipuncture or Peripheral Venous Cannulation: Randomized Double-blind COMFORT-004 Trial.

answer: @entity7


abstract: AIM: This study established predictive properties of single language milestones for @entity1 ( @entity1 ) after the age of four, as these had not previously been reported in the literature. METHODS: In this nested case-control study, @entity0 attending special needs schools for severe speech and language difficulties were matched with @entity0 attending mainstream schools. Data covering the ages of zero to four years were retrieved from well- @entity0 care clinics and the outcomes of 23 language milestones in the Dutch Developmental Instrument were analysed. The predictive properties were expressed as positive likelihood ratios, sensitivity and specificity. RESULTS: We included 253 pairs of @entity0 with and without @entity1 , aged from four to 11 years. The mean age was eight years and three months, and 77% were @entity0 . From the age of 18 months, cases and controls differed significantly on all milestones (p < 0.01). After 24 months, the language milestones had positive likelihood ratios that ranging from 6 to 108. In general, language milestones had a high specificity (range 77-100%), but the sensitivity was relatively low (range 0-68%). CONCLUSION: Failure to meet language milestones from the age of 24 months was predictive of @entity1 , but the use of separate milestones had limited value due to low sensitivity.

title: Failure to meet language milestones at two years of age is predictive of XXXX .

answer: @entity1


abstract: Two disorders of neuromuscular transmission producing @entity1 and easy fatigability which may confront the physician are @entity3 and the @entity5 . The former has @entity2 and signs of oculobulbar and then @entity1 with rapid decline of action potential and contractile strength with repetitive use and nerve-muscle stimulation. Anticholinesterases improve strength. The @entity5 has @entity2 and signs of pelvic girdle, pectoral girdle and proximal limb @entity1 . This is worst when first starting to use or carry out nerve muscle stimulation in the rested muscles. It improves significantly for a time with use or on rapid stimulation, and then declines with continued activation. Deep tendon reflexes are sluggish or absent. @entity0 is often associated. @entity4 improves the strength. Other features and possible underlying mechanisms of the two disorders help to differentiate and treat them.

title: XXXX and the @entity5 .

answer: @entity3


abstract: UNASSIGNED: Pharmaceuticals are increasingly detected in environmental matrices, but information on their trophic transfer in aquatic food webs is insufficient. This study investigated the bioaccumulation and trophic transfer of 23 pharmaceuticals in Taihu @entity9 , China. Pharmaceutical concentrations were analyzed in surface water, sediments and 14 aquatic species, including plankton, invertebrates and fish collected from the @entity9 . The median concentrations of the detected pharmaceuticals ranged from not detected (ND) to 49  ng/L in water, ND to 49  ng/g dry weight (dw) in sediments, and from ND to 130  ng/g dw in @entity10 . Higher concentrations of pharmaceuticals were found in zoobenthos relative to plankton, shrimp and fish muscle. In fish tissues, the observed pharmaceutical contents in the liver and brain were generally higher than those in the gills and muscle. Both bioaccumulation factors (median BAFs: 19-2008  L/kg) and @entity10 -sediment accumulation factors (median BSAFs: 0.0010-0.037) indicated a low bioaccumulation potential for the target pharmaceuticals. For eight of the most frequently detected pharmaceuticals in food webs, the @entity5 ( @entity5 ) were analyzed from two different regions of Taihu @entity9 . The @entity5 for @entity8 , @entity2 , @entity4 , @entity7 , @entity0 , @entity6 , @entity3 and @entity1 in the two food webs ranged from 0.28 to 1.25, suggesting that none of these pharmaceuticals experienced trophic magnification. In addition, the pharmaceutical @entity5 did not differ significantly between the two regions in Taihu @entity9 .

title: Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater XXXX .

answer: @entity9


abstract: UNASSIGNED: A large proportion of @entity0 with @entity6 movement @entity2 (iRBD) develop a synucleinopathy, mostly @entity4 , @entity5 with @entity7 , and @entity8 . Therefore, identifying markers of @entity3 in iRBD could have major implications. We aimed to assess the usefulness of electroencephalography (EEG) spectral analysis performed during wakefulness for predicting the development of a @entity3 in iRBD. Fifty-four iRBD @entity0 , 28 of whom developed @entity4 , @entity8 , or @entity5 with @entity7 (mean follow-up: 3.5  years), and 30 healthy controls underwent at baseline a resting-state waking EEG recording, neurological exam, and neuropsychological assessment. Absolute and relative spectral powers were analyzed for 5 frequency bands in frontal, central, parietal, temporal, and occipital regions. The slow-to-fast [(    +   )/(b1  + b2)] power ratio for each of the 5 cortical regions and the dominant occipital frequency were calculated as an index of @entity1 . @entity0 who developed disease showed higher absolute delta and theta power in all 5 cortical regions compared to disease-free @entity0 and controls. The slow-to-fast power ratio was higher in all regions in @entity0 who developed disease than in the 2 other groups. Moreover, @entity0 who developed disease had a slower dominant occipital frequency compared to controls. The only significant difference observed between disease-free iRBD @entity0 and controls was higher absolute delta power in frontal and occipital regions in iRBD @entity0 . Specific EEG abnormalities were identified during wakefulness in iRBD @entity0 who later developed a synucleinopathy. EEG slowing is a promising marker of @entity3 in iRBD @entity0 .

title: Electroencephalogram slowing predicts @entity3 in @entity6 movement XXXX .

answer: @entity2


abstract: This study evaluated the predictive value of @entity4 PET for distant @entity1 -free survival and peritoneal recurrence-free survival as well as recurrence-free survival and overall survival after curative surgical resection in @entity0 with advanced @entity3 (AGC). METHODS: Two hundred seventy-nine @entity0 with AGC who underwent preoperative @entity4 PET and subsequent curative surgical resection were included. The @entity2 -to-normal liver uptake ratio (TLR) of @entity2 was measured, and the prognostic significance of TLR and @entity2 factors for distant @entity1 -free survival, peritoneal recurrence-free survival, recurrence-free survival, and overall survival was assessed. RESULTS: The 5-y recurrence-free survival, peritoneal recurrence-free survival, distant @entity1 -free survival, and overall survival rates were 46.9%, 68.5%, 76.0%, and 58.1%, respectively. Depth of @entity2 invasion, lymph node @entity1 , lymphovascular invasion, and TLR were independent prognostic factors for both recurrence-free survival and overall survival (P<0.05). For distant @entity1 -free survival, lymphovascular invasion and TLR were independent risk factors (P<0.05). In @entity0 with a TLR of 2.0 or less, the 5-y distant @entity1 -free survival rate was 95.5%; in @entity0 with a TLR greater than 2.0, the 5-y distant @entity1 -free survival rate was 68.8%. For peritoneal recurrence-free survival, TLR showed no statistical significance (P=0.7) whereas pT stage, lymph node @entity1 , Lauren classification, and Bormann type were independent prognostic factors (P<0.05). CONCLUSION: @entity4 uptake of AGC is an independent prognostic factor for distant @entity1 -free survival, recurrence-free survival, and overall survival. The possibility of distant @entity1 during follow-up should be considered in @entity0 with high @entity4 uptake.

title: Relationship Between @entity4 Uptake on PET and Recurrence Patterns After Curative Surgical Resection in @entity0 with Advanced XXXX .

answer: @entity3


abstract: UNASSIGNED: While important changes in circadian rhythms take place during adolescence and young adulthood, it is unclear how circadian profiles during this period relate to @entity1 . This study aimed to: (i) characterise morningness-eveningness preference in young @entity0 with primary @entity2 , @entity4 , @entity3 as compared to healthy controls, and (ii) to investigate associations between morningness-eveningness preference and the severity of @entity1 symptoms. Four hundred and ninety-six males and females aged between 12 and 30 years were divided into five groups according to primary diagnosis. The Hamilton Depression Rating Scale and the Brief Psychiatric Rating Scale were administered by a research psychologist and @entity0 completed the Kessler Psychological Distress Scale and the Horne-  stberg Morningness-Eveningness Questionnaire (ME). ME scores were significantly lower (i.e. higher levels of "eveningness") in all @entity0 diagnosis subgroups compared to the control group. The @entity6 group had higher ME scores than the @entity4 and @entity2 groups. Compared to the control group, the @entity2 , @entity4 and @entity3 had a significantly higher proportion of "moderate evening" types, with a similar trend for the @entity6 group. The proportion of "extreme evening" types was significantly higher in the @entity2 and @entity4 subgroups than in the control group. Lower ME scores correlated with worse @entity5 in males from the bipolar group. Lower ME scores correlated with higher @entity4 severity in females with @entity4 and in males with @entity3 . These results suggest that young @entity0 with various @entity1 , especially those with @entity7 , present with a stronger "eveningness" preference and higher rates of evening chronotypes than healthy controls from the same age group. Later chronotypes were generally associated with worse @entity5 and symptoms severity. These associations were modulated by sex and primary diagnosis.

title: Clinical correlates of chronotypes in young XXXX with @entity1 .

answer: @entity0


abstract: BACKGROUND: No uniform consensus exists to decide type of fixation for arthroscopic anterior cruciate ligament reconstruction. Hypothsis: There is similar functional outcome after rigid @entity1 compared to other methods of fixation which has been published. STUDY DESIGN: Retrospective observational study. METHODS: A total of 50 @entity0 underwent arthroscopic anterior cruciate ligament reconstruction with hamstring tendons using femoral Rigid @entity1 cross-pin and interference screw tibial fixation. The evaluation methods were clinical examination, IKDC scores, Lysholm and pre injury and post reconstruction Tegner score. @entity0 were followed up from minimum of 6 months to 4 year seven months. RESULTS: C In our study of sample size 50 we found that mean age of @entity0 was 30.8 Years with male preponderance. Mean post operative IKDC and Lysholm score has been 75.6 and 84.4 respectively. Mean Tegner pre-injury score and post reconstruction score has been 5.4 and 4.26. Box plot comparison of pre injury and post operativeTegner score reveals a statistically significant difference with respect to paired t test P<0.001. CONCLUSIONS: Arthroscopic anterior cruciate ligament reconstruction with femoral rigid @entity1 cross pins and tibial interference screws results in comparable short term to midterm functional results compared to other types of fixation.

title: Functional Outcome Following Arthroscopic ACL Reconstruction with Rigid XXXX : A Retrospective Observational Study.

answer: @entity1


abstract: OBJECTIVE: Constitute hypothesis for origin of supernumerary phantom limb (SPL) after @entity1 . METHOD: Single case description, review of literature and formulation of hypothesis. RESULTS: A 59-year-old lady was evaluated for complaints of left-sided @entity5 and extra limbs attached to her left shoulder for the past 7 months. Neuropsychological assessment revealed left hemineglect with SPL, and profile suggested bilateral frontal, right parietotemporal and basal ganglia involvement. Magnetic resonance imaging brain scan showed gliotic cavity secondary to the old haematoma in right putamen with white matter changes in the right frontoparietotemporal lobes. CONCLUSIONS: The conceptual framework of @entity4 can be used to classify many of the @entity0 of body representation. Generation of SPL comes under the subtype of pathology of updating among the @entity2 . The continuous updating allows the @entity4 to modulate perceptual processing of objects according to their position in space. Brain areas classified as parts of motor system can, under pathological conditions ( @entity3 ), influence body perception. So, when she used to move her arm, the representation of the estimated position was not updated by the motor commands. Sensory and motor information therefore becomes discrepant, and failure to integrate these two sources of information leads to loss of normal coherence, and the perceived shape of the body was altered by adding a SPL to accommodate the discrepancy.

title: XXXX with supernumerary phantom limb: case study, review of literature and pathogenesis.

answer: @entity1


abstract: @entity1 are mostly caused initially by dermatophytes, @entity2 and less frequently by bacteria. Erythrasma caused by Corynebacterium minutissimum can be confused with superficial mycoses. The aim of the study was to determine the prevalence of the etiologic agents of superficial mycoses and the frequency of Corynebacterium minutissimum in @entity1 . All the samples obtained from the 121 @entity0 with @entity1 were examined directly with the use of 20% @entity3 mounts and Gram stain under the microscope and cultured on Sabouraud's dextrose agar plates. In identification of superficial mycoses, the rate was found to be 14% with the cultural method and 14% with direct microscopic examination. Using a combination of direct microscopic examination and culture, a 33.8% ratio was achieved. In the culture of these samples, the most isolated factor was @entity5 (33.7%). In 24 of the @entity0 (19.8%) Corynebacterium minutissimum was detected by Gram staining, in 6 of these @entity0 @entity5 was found, @entity6 was found in 2 and Trichosporon spp. was found in 1. The examination of @entity4 in the laboratory, the coexistence of erythrasma with dermatophytes and @entity2 should be considered.

title: XXXX : Corynebacterium minutissimum and agents of superficial mycoses.

answer: @entity1


abstract: A @entity0 's ability to cope with having @entity1 may be an important factor in determining their quality of life. We have developed a scale to measure coping strategies in @entity0 with MND. A disease-specific and @entity0 -focused approach was employed. Open-ended interviews were used to generate initial items. Coping with the condition was an important consideration for all subjects. The final scale was administered to a sample of 44 @entity0 with MND. A factor analysis of the results demonstrated subscales comprised of distinct styles of coping. Reliability and validity were demonstrated within individual subscales. Significant correlations were shown between coping styles and psychological well being, disease duration and disability. Although still at a preliminary stage of development, the MND Coping Scale is proposed as a useful tool for further longitudinal study of coping in MND, with the potential to discover cause effect relationships between coping and psychological outcome.

title: Quality of life issues in XXXX : the development and validation of a coping strategies questionnaire, the MND Coping Scale.

answer: @entity1


abstract: @entity1 was shown to inhibit @entity2 (NE) release from sympathetic nerve endings. The purpose of this study was to examine whether endogenous @entity1 restrains NE and @entity3 release from the adrenal medulla. The effects of an @entity1 receptor antagonist, @entity7 ( @entity7 ), on @entity3 and NE release induced by intravenous administration of insulin in conscious @entity0 were examined. Plasma @entity4 were measured by HPLC with an electrochemical detector. @entity7 significantly increased plasma @entity5 in both control @entity0 and @entity0 treated with insulin. The effect of @entity7 on plasma @entity5 was significantly greater in @entity0 treated with insulin. Additional experiments were performed in adrenalectomized @entity0 to investigate the contribution of the adrenal medulla to the effect of @entity7 on plasma @entity5 . The effect of @entity7 and insulin on @entity3 in adrenalectomized @entity0 was significantly reduced compared with that of the controls. Finally, we tested whether endogenous @entity1 restrains @entity5 secretion partially through inhibiting the renin-angiotensin system. The effect of @entity7 on plasma @entity5 in @entity0 pretreated with @entity6 (an angiotensin-converting enzyme inhibitor) was reduced. These results demonstrate that under basal physiological conditions, endogenous @entity1 tonically inhibits @entity5 secretion from the adrenal medulla, and this effect is augmented when the sympathetic system is stimulated. The effect of endogenous @entity1 on @entity5 secretion from the adrenal medulla is achieved partially through the inhibitory effect of @entity1 on the renin-angiotensin system.

title: Modulation of @entity5 release by endogenous XXXX in the @entity0 adrenal medulla.

answer: @entity1


abstract: BACKGROUND: Compliance with continuous positive airway pressure (CPAP) therapy is essential in @entity0 with @entity2 ( @entity2 ), but adequate control is not always possible. This is clinically important because CPAP can reverse the morbidity and mortality associated with @entity2 . Telemedicine, with support provided via a web platform and video conferences, could represent a cost-effective alternative to standard care management. AIM: To assess the telemedicine impact on treatment compliance, cost-effectiveness and improvement in quality of life (QoL) when compared with traditional face-to-face follow-up. METHODS: A randomised controlled trial was performed to compare a telemedicine-based CPAP follow-up strategy with standard face-to-face management. Consecutive @entity2 @entity0 requiring CPAP treatment, with sufficient internet skills and who agreed to participate, were enrolled. They were followed-up at 1, 3 and 6   months and answered surveys about sleep, CPAP side effects and lifestyle. We compared CPAP compliance, cost-effectiveness and QoL between the beginning and the end of the study. A Bayesian cost-effectiveness analysis with non-informative priors was performed. RESULTS: We randomised 139 @entity0 . At 6   months, we found similar levels of CPAP compliance, and improved @entity1 , QoL, side effects and degree of satisfaction in both groups. Despite requiring more visits, the telemedicine group was more cost-effective: costs were lower and differences in effectiveness were not relevant. CONCLUSIONS: A telemedicine-based strategy for the follow-up of CPAP treatment in @entity0 with @entity2 was as effective as standard hospital-based care in terms of CPAP compliance and symptom improvement, with comparable side effects and satisfaction rates. The telemedicine-based strategy had lower total costs due to savings on transport and less lost productivity (indirect costs). TRIAL REGISTER NUMBER: NCT01716676.

title: A Bayesian cost-effectiveness analysis of a telemedicine-based strategy for the management of XXXX : a multicentre randomised controlled trial.

answer: @entity1


abstract: UNASSIGNED: Urine drug screens (UDSs) are used to identify the presence of certain medications. One limitation of UDSs is the potential for false-positive results caused by cross-reactivity with other substances. @entity3 have an extensive list of cross-reacting medications. The literature contains reports of false-positive @entity5 UDSs with multiple antidepressants and antipsychotics. We present 2 cases of presumed false-positive UDSs for @entity3 after ingestion of @entity4 . Case 1 was a 16-month-old @entity0 who accidently ingested 15 to 45 mg of @entity4 . She was lethargic and ataxic at home with 1 episode of @entity2 containing no identifiable tablets. She remained sluggish with periods of @entity1 and was admitted for observation. UDS on 2 consecutive days came back positive for @entity3 . Case 2 was of a 20-month-old @entity0 who was brought into the hospital after accidental ingestion of an unknown quantity of her father's medications which included @entity4 . UDS on the first day of admission came back positive only for @entity3 . Confirmatory testing with gas chromatography-mass spectrometry (GC-MS) on the blood and urine samples were also performed for both @entity0 on presentation to detect @entity3 and were subsequently negative. Both @entity0 returned to baseline and were discharged from the hospital. To our knowledge, these cases represent the first reports of false-positive @entity5 urine drug tests with @entity4 . In both cases, @entity4 was the drug with the highest likelihood of causing the positive @entity5 screen. The implications of these false-positives include the possibility of unnecessary treatment and monitoring of @entity0 .

title: Case Reports of @entity4 Causing False-Positive Urine XXXX Drug Screens in @entity0 .

answer: @entity5


abstract: BACKGROUND: Next-generation sequencing (NGS) offers great opportunities for studying the biology of insect vectors of disease. Prerequisites for successful analyses include high quality annotated genome assemblies and that techniques designed for use with model organisms be tested and optimised for use with these insects. We aimed to test and improve genomic tools for studying the major @entity3 vector @entity4 . RESULTS: To guide future RNAseq transcriptomic studies of An. funestus, we compared two methods for enrichment of non-ribosomal RNA for analysis: enrichment of polyadenylated RNA and ribosomal RNA depletion using a kit designed to deplete @entity0 / @entity2 / @entity1 rRNA. We found large differences between the two methods in the resulting transcriptomes, some of which is due to differential representation of polyadenylated and non-polyadenylated transcripts. We used the RNAseq data for validation and targeted manual editing of the draft An. funestus genome annotation, validating 62  % of annotated introns, manually improving the annotation of seven gene families involved in the detoxification of xenobiotics and integrated two published transcriptomic datasets with the recently published genome assembly. CONCLUSIONS: The mRNA enrichment method makes a substantial, replicable difference to the transcriptome composition, at least partly due to the representation of non-polyadenylated transcripts in the final transcriptome. Therefore, great care should be taken in comparing gene expression data among studies. Ribosomal RNA depletion of total RNA using a kit designed to deplete @entity0 / @entity2 / @entity1 rRNA works in mosquitoes and, we argue, results in a truer representation of the transcriptome than poly(A) selection. The An. funestus genome annotation can be considerably improved with the help of these new RNAseq data and further guided manual gene editing efforts will be of great benefit to the Anopheles research community for studies of this insect's genome and transcriptome.

title: Molecular tools for studying the major XXXX vector @entity4 : improving the utility of the genome using a comparative poly(A) and Ribo-Zero RNAseq analysis.

answer: @entity3


abstract: BACKGROUND: The 585-nm flashlamp-pumped pulsed-dye laser (PDL) has proven to be the treatment of choice for certain keloids and @entity2 , but the precise fluence, numbers of treatment, and treatment interval remain anecdotal. OBJECTIVE: This study was performed to determine whether the therapeutic outcome of the PDL varies with the energy density (fluence) of the laser pulses and numbers of treatment. METHOD: Ten previously untreated, erythematous, keloidal or @entity1 median sternotomy scars of 10 @entity0 were divided into 4 segments and were randomly treated with a 585-nm PDL at a fluence of 3, 5, and 7 J/cm(2) to 3 of 4 segments every 4 weeks for a total of 6 treatment sessions. One segment of each @entity0 's scars was untreated and served as a control. Clinical improvement including scar height, erythema, and pliability was evaluated before treatment and every 8 weeks for a total period of 32 weeks. Self-assessment was also determined by @entity0 on a 25% increment of improvement scale comparing week 0 and week 32. RESULTS: A significant improvement in scar height, erythema, and pliability was noted in all laser-treated scar areas. There was no significant difference in treatment outcome versus the fluence of the laser (3, 5, and 7 J/cm(2)), although there was a trend for lower fluences to show more improvement. Objective clinical improvement was seen as early as week 16, after more than two treatments were given. Multiple treatments (>2) appeared to provide a greater percentage of scar resolution. CONCLUSIONS: The clinical improvement of scars after PDL treatment demonstrates no statistically significant fluence dependence in this study, but a trend toward better response with lower fluences is seen. In addition, multiple treatment sessions are suggested for achieving greater response.

title: Energy density and numbers of treatment affect response of keloidal and XXXX sternotomy scars to the 585-nm flashlamp-pumped pulsed-dye laser.

answer: @entity1


abstract: BACKGROUND: Exposure to fine particulate matter (PM2.5) may promote hepatic tumorgenesis through low-grade @entity2 . Therefore, we assessed the association of long-term exposure levels of PM2.5 and subsequent risk of @entity4 ( @entity4 ) and investigated the mediation effect of @entity2 as represented by @entity5 aminotransferase (ALT) on this association. METHODS: Between 1991 and 1992, we recruited 23 820 @entity0 in Taiwan with no history of @entity4 . Case @entity0 of @entity4 were ascertained through computerized data linkage with the National @entity1 Registry and death certification systems. @entity0 ' exposures to PM2.5 were based on a four-year average retrieved from stationary monitoring sites. Cox proportional hazards models were used to assess the association between PM2.5 exposure and @entity4 incidence. Mediation effects of ALT on PM2.5-associated @entity4 incidence were estimated. RESULTS: A total of 464 @entity4 cases were newly diagnosed with a median follow-up of 16.9 years. Statistically significantly increasing trends between PM2.5 exposures and ALT were observed on the Main Island and Penghu Islets. The adjusted hazard ratio (HR) for @entity4 on the Penghu Islets was 1.22 (95% confidence interval [CI] = 1.02 to 1.47) per PM2.5 interquartile range (IQR) increment (0.73   g/m(3)) exposure. We also found a positive association between PM2.5 exposure (per IQR increment, 13.1   g/m(3) ) and @entity4 incidence on the Main Island. Furthermore, ALT had a statistically significant mediation effect on PM2.5-associated @entity4 incidence (HR = 1.17, 95% CI = 1.02 to1.52 on the Main Island; HR = 1.04, 95% CI = 1.03 to 1.07 on the Penghu Islets) per PM2.5 IQR increment. CONCLUSIONS: Long-term PM2.5 exposure increased the risk for @entity3 , and chronic @entity2 of the liver may underlie the pathogenesis.

title: Fine Particle Pollution, @entity5 Transaminase, and XXXX : A Taiwanese Prospective Cohort Study (REVEAL-HBV).

answer: @entity3


abstract: The current taxonomy of probiotic @entity0 bacteria is reviewed with special focus on the genera @entity6 , @entity7 and Enterococcus. The physiology and taxonomic position of species and strains of these genera were investigated by phenotypic and genomic methods. In total, 176 strains, including the type strains, have been included. Phenotypic methods applied were based on biochemical, enzymatical and physiological characteristics, including growth temperatures, cell wall analysis and analysis of the total soluble cytoplasmatic proteins. Genomic methods used were pulsed field gel electrophoresis (PFGE), randomly amplified polymorphic DNA-PCR (RAPD-PCR) and DNA-DNA hybridization for bifidobacteria. In the genus @entity6 the following species of importance as probiotics were investigated: @entity4 group, @entity1 group and @entity2 / @entity5 group. Most strains referred to as @entity4 in probiotic products could be identified either as @entity9 or as @entity6 , both members of the @entity4 group. A similar situation could be shown in the @entity1 group, where most of the strains named @entity1 belonged to @entity3 subspp. A recent proposal to reject the species @entity3 and to include this species in the restored species @entity1 with a neotype strain was supported by protein analysis. @entity7 spp. strains have been reported to be used for production of fermented dairy and recently of probiotic products. According to phenotypic features and confirmed by DNA-DNA hybridization most of the bifidobacteria strains from dairy origin belonged to @entity8 , although they were often declared as @entity7 by the manufacturer. From the genus Enterococcus, probiotic Ec. faecium strains were investigated with regard to the vanA-mediated resistance against glycopeptides. These unwanted resistances could be ruled out by analysis of the 39 kDa resistance protein. In conclusion, the taxonomy and physiology of probiotic @entity0 bacteria can only be understood by using polyphasic taxonomy combining morphological, biochemical and physiological characteristics with molecular-based phenotypic and genomic techniques.

title: Taxonomy and physiology of probiotic XXXX bacteria.

answer: @entity0


abstract: The effect of @entity1 injections on the ultrastructural localization of @entity2 ( @entity2 ) was studied in the mitral cells of the @entity0 olfactory bulb. In control animals, electron-dense reaction product representing @entity2 activity was observed in lysosomes, lipofuscin granules, short cisternae located close to the granular endoplasmic reticulum, and dense granules. Lysosomes and lipofuscin granules were the most intensely stained organelles. @entity2 -containing organelles were localized mainly to the cell body and were randomly distributed in the perikaryal cytoplasm. Twenty-four hours after a 100-micrograms intracerebroventricular @entity1 injection, the distribution of @entity2 -containing organelles was drastically altered. Short cisternae and dense granules containing @entity2 reaction product were noticeably absent in these preparations. Lysosomes and lipofuscin granules were depleted from the perikaryal cytoplasm and were concentrated in dendrites. Lysosomes were observed to extend for considerable distances in dendrites where they acquired elongated and dumbbell shapes. The shapes of some of these labeled lysosomes gave the impression that they were actively being "pulled" into the dendrites. These results indicate that microtubules sequester lysosomes to the perikaryal cytoplasm and suggest the presence of a novel transport system responsible for the movement of lysosomes from the cell body to the dendrites.

title: Dendritic transport. II. Somatofugal movement of neuronal lysosomes induced by XXXX : evidence for a novel transport system in dendrites.

answer: @entity1


abstract: Scintimammography is a relatively new, non-invasive diagnostic modality in the evaluation of @entity0 . The purpose of the current study was to review the existing literature on the accuracy of scintimammography in the diagnosis of @entity0 . A search of all articles published between 1st January 1967 and 31st December 1999 was conducted. A total of 64 unique studies were selected. Each scientific paper was reviewed for scientific merit by an epidemiologist, a surgeon and a surgical resident. Assessment of scientific merit was based on a scoring scheme developed for the study. The articles included in this review reported data on a total of 5340 @entity1 assessed for @entity0 with scintimammography. The aggregated summary estimates on these @entity1 were sensitivity: 85.2% and specificity: 86.6%. For @entity1 with a palpable mass the sensitivity and specificity were 87.8 and 87.5%, respectively. For @entity1 without a palpable mass the sensitivity was 66.8% and that for specificity was 86.9%. The results of this review have shown that scintimammography may be used effectively as an adjunct to mammography and physical examination in the diagnosis of @entity0 .

title: XXXX diagnosis by scintimammography: a meta-analysis and review of the literature.

answer: @entity0


abstract: We studied the psychological impact and psychosocial consequences of direct presymptomatic testing for @entity3 in Norway. We interviewed 30 out of a total of 43 @entity0 at risk for @entity3 who had been tested one to three years earlier, and had been through the test program, and 19 of their spouses. We also included 16 @entity0 at risk who had decided not to take the test. 22 @entity0 were non-carriers, and seven carriers. One had decided not to know the answer so far. 13 out of 30 answered that the risk of getting @entity3 had influenced choices they had made in their lives, but quite a few did not know that they were at risk before they had grown up. Six couples out of 21 had divorced after the test; only three said it happened because of the test result. The main problem for many of the @entity0 who now know they are non-carriers is that siblings already are sick or know they will get the disease. 15 @entity0 (50%) experienced the need for some kind of psychiatric treatment during the pre-test period, during the test procedure, or after the test. Eight @entity0 said they had wanted a closer follow-up after the test; most of them had got a negative answer. In this study most of those at risk had adapted reasonably well to the test results. Only seven @entity0 out of 30 were found to be carriers in our study. We therefore have reason to believe that among the 13 tested @entity0 who declined to be involved in the study, the majority had been identified as carriers. Our findings may lend support to a hypothesis suggesting two kinds of response to being identified as carrier. According to studies of @entity2 , one group adjusts reasonably well. The other group responds by avoiding follow-up contact with professional teams, which suggests more @entity1 and distress.

title: [Psychosocial consequences of presymptomatic genetic testing. A retrospective study of testing for XXXX ].

answer: @entity3


abstract: 1. Comparative studies of the @entity3 -directed @entity1 -incorporating activity of cell-free systems derived from @entity0 and @entity2 livers demonstrated markedly lower activity in the @entity2 liver system. 2. The @entity2 liver cell @entity4 contained the factor(s) responsible for this lower activity. Ribosomes from @entity2 and @entity0 performed equally well in the presence of @entity0 liver cell @entity4 . @entity2 liver cell @entity4 , when mixed with @entity0 liver cell @entity4 , caused an inhibition of incorporation of @entity1 into acid-insoluble material. 3. Though ribosomal preparations and cell @entity4 from both @entity0 and @entity2 liver degraded @entity3 to some extent, the @entity2 liver cell @entity4 contained the largest amount of activity. 4. @entity0 liver cell @entity4 inhibited the @entity5 activities of ribosomal preparations, but no such @entity5 inhibition could be demonstrated with @entity2 liver cell @entity4 .

title: XXXX activity in cell-free amino acid-incorporating systems from @entity2 liver.

answer: @entity5


abstract: 1. The mechanisms of long-term potentiation (LTP) and long-term @entity3 (LTD) induced by brief high frequency stimulation (HFS), paired with a particular pattern and amplitude of depolarisation has been investigated in the medial perforant pathway of the dentate gyrus of the 2- to 3-week-old @entity0 hippocampus in vitro. 2. @entity4 ( @entity2 ) receptor (NMDAR) activation was measured quantitatively during HFS-induced NMDAR-dependent LTP, LTD and at the LTD--LTP crossover point in order to test the hypothesis that the induction of the particular form of plasticity depends on the intensity of NMDAR activation. 3. The induction of LTD, the LTD--LTP crossover point and LTP was associated with an increasing NMDAR charge transfer. 4. In addition to the NMDAR-dependent LTD, a group I metabotropic @entity5 receptor (mGluR)-dependent LTD could be induced by high intensity HFS paired with depolarisation under conditions of NMDAR inhibition. 5. The induction of mGluR-dependent LTD requires membrane depolarisation, @entity1 influx via L-type @entity1 channels and a rise in intracellular @entity1 . 6. Quantal analysis involving minimal stimulation demonstrated that the mGluR-dependent LTD induction was associated with a decrease in potency and an increase in failure rate.

title: @entity2 receptor- and metabotropic @entity5 receptor-dependent synaptic plasticity induced by high frequency stimulation in the XXXX dentate gyrus in vitro.

answer: @entity0


abstract: OBJECTIVE: This study focused on the efficacy of endoscopic decompression of the foramen guided by endoscopic aware-state @entity2 . BACKGROUND DATA: Endoscopic foraminoplasty consists of undercutting of the facet joint and endoscopic discectomy, mobilization and neurolysis of the exiting and transiting nerves, and ablation of osteophytes. This study sought the outcome of endoscopic foraminoplasty in 250 consecutive @entity0 followed for a minimum of 2 years, reviewed and assessed by an external independent assessor. It was applied to @entity0 with @entity4 and sciatica in multilevel @entity3 and also to those with prior surgery. METHODS: A prospective study of endoscopic laser foraminoplasty was performed on 121 males and 129 females with an average age of 48 years (21-86 years), followed for an average period of 30 months (26-43 months). The average preoperative duration of back, buttock, or leg @entity2 was 6.1 years (5-11 years). A total of 30% had undergone prior open spinal surgery. RESULTS: The cohort integrity at follow up was 97%. Outcome was analyzed using the percentage change in Oswestry Disability Scores and visual analogue @entity2 scores. Clinically relevant change in @entity2 and disability was observed in 73%. Using a percentage change in Oswestry Disability Score of 50 or more to determine good and excellent outcomes, 60% of @entity0 exceeded this score. A total of 95% @entity0 required no further surgical intervention. CONCLUSIONS: Endoscopic laser foraminoplasty provides a minimalist means of exploring the extraforaminal zone, the foramen, the disc, and the epidural space and performing discectomy, lateral recess decompression, osteophytectomy, and neural mobilization. Performed in the aware state, it serves to identify and localize precisely the causal source of @entity2 in multilevel @entity1 , in revision surgery, and in the infirm and elderly without open fusion or decompression.

title: Endoscopic foraminoplasty: a prospective study on 250 consecutive XXXX with independent evaluation.

answer: @entity0


abstract: PURPOSE: In a series of @entity2 ( @entity2 ) @entity0 , we evaluated the sensitivities of the individual microsatellites recommended by the National @entity1 Institute (NCI) consensus workshop for detection of @entity5 ( @entity3 ). On the basis of this evaluation, we developed a three-marker assay that assigns @entity3 ( @entity3 ) in a multiplex polymerase chain reaction. METHODS: Individual marker sensitivity was assessed in 18 @entity2 . Multiplex and NCI assays were then assessed in a series of 120 @entity0 with early-onset @entity4 . RESULTS: The sensitivity of microsatellite markers BAT25, BAT26, D2S123, D5S346, and D17S250 for ASI in @entity2 was 100%, 94%, 72%, 50%, and 50%, respectively. The three most accurate markers were combined and optimized in a multiplex assay that assigned @entity3 whenever at least two of three markers revealed ASI. In early-onset @entity4 , the prevalence of @entity3 determined by the multiplex assay and by the NCI assay was 16% and 23%, respectively. The @entity1 and @entity0 with @entity3 identified by the NCI assay lacked the traits characteristic of @entity3 seen in @entity1 and @entity0 identified by the multiplex assay: retention of heterozygosity (NCI additional 22% v multiplex 84%; P =.003), characteristic @entity1 morphology (0% v 64%; P =.006), and 5-year @entity1 survival rate (44% v 100%; P =.0003). CONCLUSION: The multiplex assay identifies @entity4 with @entity3 by assessing three highly accurate microsatellite markers. This assay identifies a smaller @entity3 cohort with more homogeneous clinical features and is superior as a marker of favorable prognosis. It merits prospective evaluation as a marker of prognosis and as a screening test for @entity2 .

title: Automated, multiplex assay for XXXX in @entity2 .

answer: @entity5


abstract: OBJECTIVE: The statement that @entity2 are @entity1 has to be seriously questioned from a surgical standpoint. The purpose of this study was 1) to analyze the operative reports of a personal series of @entity2 to evaluate the percentages of the @entity1 that could be dissected by passing in the extrapial plane (i.e., "cleavable") and of those in which the dissection had to be subpial (i.e., "noncleavable") and 2) to see whether preoperative angiography could help in predicting cleavability. METHODS: The series includes 150 consecutive @entity0 with @entity2 diagnosed with computed tomographic scans and explored preoperatively by selective external/internal carotid angiography, operated on using microsurgical techniques, and followed for more than 4 years. RESULTS: Dissection between @entity1 and underlying cortex could be achieved in the extrapial plane predominantly (i.e., on more than two-thirds of the interface) in only 54.6% of @entity0 . On angiography, the pial-cortical arterial supply participated in at least equal part with the meningeal-dural arterial supply in vascularization of the @entity1 in 59.4% of @entity0 . In this group, dissection could pass through the extrapial plane in only 34.8% of @entity0 . Conversely, when meningeal-dural arterial supply was predominant on angiography, which occurred in 40.6% of @entity0 , dissection could be achieved in the extrapial plane in 83.6% of @entity0 . This difference is statistically significant (P < 0.001). CONCLUSION: Participation of pia mater in the vascular supply of @entity2 , and consequently, difficulty of dissection, can be predicted preoperatively on angiography. Knowledge of the arterial supply of the @entity1 before surgery is an important aid to the surgeon in preparing for and performing the operation.

title: Most @entity2 are not XXXX : anatomic-surgical evidence and angiographic predictibility.

answer: @entity1


abstract: BACKGROUND: Since most studies concerning the frequency of @entity0 of @entity3 are based on samples of @entity1 services, the results of these studies may be influenced by their selection procedure. For this reason, we investigated the frequency of non-cognitive @entity3 symptoms based on an epidemiological nursing home study. METHODS: The sample consisted of 249 nursing home residents in Austria who were interviewed with the Clinical Interview Schedule within 2 weeks after admission (T1) and again 6 months later (T2). For the analyses of the @entity0 among the demented, only manifest clinical abnormalities observed during the interview were included. Further, mobility and impaired self-care were assessed. RESULTS: At admission, @entity3 was found in 63.9% of the sample. At T1, 38%, and at T2, 36.1% of the demented suffered from any @entity0 . Flattened or incongruous affect, suspiciousness or @entity1 , and @entity2 were found most frequently. Multiple regression analyses showed that @entity0 increase the risk for impaired self-care. DISCUSSION: Despite the fact that the frequency of several @entity0 found in our survey is lower than reported from studies based on @entity1 samples, a high proportion of the demented in nursing homes suffer from such symptoms. Non-cognitive symptoms of @entity3 increase the risk for an impaired self-care, which supports the assumption that they raise the costs of caring.

title: Non-cognitive symptoms of XXXX in nursing homes: frequency, course and consequences.

answer: @entity3


abstract: @entity0 intraepithelial lymphocytes are T cells primarily of the @entity5 + phenotype located between intestinal epithelial cells. The cytotoxic and suppressor activities of these lymphocytes are largely unexplored. The spontaneous cytotoxic activity of these cells is evaluated in this study. Jejunal intraepithelial lymphocytes spontaneously lysed a variety of epithelial cell @entity1 lines ( @entity7 and @entity3 ) but not the highly natural killer-sensitive K-562 cells. Cold target inhibition studies showed that these lymphocytes preferentially bind the DLD-1 @entity6 cells rather than the K-562 cells. Pretreatment of the effector cells with @entity4 did not change their cytotoxic activity. The cytotoxic cells are T lymphocytes (expressing @entity8 , CD3, and @entity5 ). In contrast, the spontaneous cytotoxic activity of peripheral blood lymphocytes is directed against both epithelial cell targets and K-562 cells, is enhanced by @entity4 , and is effected by natural killer cells (expressing @entity8 , @entity9 , and NKH1). Thus, the spontaneous @entity2 of intraepithelial lymphocytes differs from that of peripheral blood lymphocytes in their target cell restriction, lack of response to interferon gamma, and effector cell phenotype. Lymphocytes in the intestinal epithelium may have a novel and important role in recognizing and destroying transformed epithelial cells and @entity6 .

title: Spontaneous @entity2 of @entity0 intraepithelial lymphocytes against epithelial cell XXXX .

answer: @entity1


abstract: UNASSIGNED: High systolic blood pressure (SBP) variability has been associated with higher risk for target-organ damage. In a cross-sectional study done in a tertiary outpatient @entity2 clinic, we compared short-term SBP variability among controlled and uncontrolled @entity2 @entity0 and evaluated the association between higher levels of SBP variability and diastolic function and @entity3 ( @entity3 ). @entity0 were evaluated by 24-h ambulatory blood pressure monitoring and transthoracic Doppler echocardiogram. Blood pressure (BP) variability was evaluated by the time-rate index and high variability corresponded to index values in the top quartile of distribution. Echocardiographic parameters were compared in @entity0 with and without higher BP variability within controlled and uncontrolled office BP (   140/90   mm   Hg). The analyses included 447 @entity0 with 58  12 years of age, 67% were @entity0 , 68% white, 43% current or previous smokers and 32% with @entity1 . Among the whole sample, 137 @entity0 had controlled and 310 uncontrolled BP. The 75th percentile cutoff points for the time-rate index were 0.502   mm   Hg   min(-1) and 0.576   mm   Hg   min(-1) for @entity0 with controlled and uncontrolled BP, respectively. After adjustment for confounders, the time-rate index did not differ between controlled and uncontrolled @entity0 . BP variability was not associated with @entity3 or diastolic function in controlled and uncontrolled BP after adjustment for 24-h SBP and age. @entity0 with controlled and uncontrolled BP had similar SBP variability assessed by time-rate index, which was not associated with @entity3 or diastolic function. These findings should be confirmed in studies with larger sample size.Journal of @entity0 @entity2 advance online publication, 15 October 2015; doi:10.1038/jhh.2015.106.

title: Blood pressure variability in controlled and uncontrolled blood pressure and its association with XXXX and diastolic function.

answer: @entity3


abstract: Hepatic lipid synthesis is known to be regulated by food consumption. In rodents fasting decreases the synthesis of @entity1 as well as @entity3 . Refeeding a high @entity4 /low fat diet enhances @entity2 synthesis by 5- to 20-fold above the fed state, whereas @entity1 synthesis returns only to the prefasted level. @entity6 regulatory element binding proteins (SREBPs) are transcription factors that regulate genes involved in @entity1 and @entity2 synthesis. Here, we show that fasting markedly reduces the amounts of @entity8 in @entity0 liver nuclei, with corresponding decreases in the mRNAs for SREBP-activated target genes. Refeeding a high @entity4 /low fat diet resulted in a 4- to 5-fold increase of nuclear @entity5 above nonfasted levels, whereas nuclear @entity7 protein returned only to the nonfasted level. The hepatic mRNAs for @entity2 biosynthetic enzymes increased 5- to 10-fold above nonfasted levels, a pattern that paralleled the changes in nuclear @entity5 . The hepatic mRNAs for enzymes involved in @entity1 synthesis returned to the nonfasted level, closely following the pattern of nuclear @entity7 regulation. @entity0 that overproduce nuclear @entity5 failed to show the normal decrease in hepatic mRNA levels for @entity1 and @entity2 synthetic enzymes upon fasting. We conclude that SREBPs are regulated by food consumption in the @entity0 liver and that the decline in nuclear @entity5 upon fasting may explain in part the decrease in mRNAs encoding enzymes of the @entity2 biosynthetic pathway.

title: Regulation of @entity6 regulatory element binding proteins in livers of fasted and refed XXXX .

answer: @entity0


abstract: OBJECTIVES: This study reports survival, functional status, the change in post-operative left ventricular dimensions and function after'undersized mitral annuloplasty' in @entity0 with non-ischaemic @entity2 and secondary @entity1 . @entity0 AND METHODS: Between 2003 and 2009 10 @entity0 (mean age 61.5 +/- 14 years) with non-ischaemic, @entity2 with left ventricular ejection fraction (LV EF) <40% (mean +/- SD, 30.7 +/- 5.27) underwent isolated mitral repair and annuloplasty. All @entity0 were receiving maximal drug therapy. Preoperatively 1 @entity0 (10%) was functioning in New York Heart Association (NYHA) class II, 8 @entity0 (80%) in class III and 1 @entity0 (10%) in class IV. Transthoracic echocardiography was performed immediately before surgery and one year after surgery to assess valvular and ventricular function. For statistical analysis we have used paired t-tests and Wilcoxon's rank test. RESULTS: There were no hospital deaths. Duration of intubation and ICU stay was 1.8 +/- 1.3 and 3.8 +/- 1.8 days, respectively. Functional class after one year was significantly better than the preoperative value (from 3.00 +/- 0.47 to 1.40 +/- 0.52, P<0.001). One year post-operative data showed significant improvement of LV EF (from 30.70 +/- 5.27 to 46.60 +/- 14.47%) and a decrease of the left ventricular diastolic dimension (LVDd) (from 59.30 +/- 5.62 to 50.70 +/- 6.04 mm). CONCLUSION: Isolated undersized mitral annuloplasty in @entity0 with non-ischaemic @entity2 with associated @entity1 , is a safe method with the potential of improving functional class, LV EF, and LVDd after one year.

title: Mitral annuloplasty for @entity2 with XXXX .

answer: @entity1


abstract: Seventeen examples of a variant of @entity4 in situ (DCIS) composed exclusively or predominantly of spindle cells arranged in fascicles, whorls, and solid sheets are described. The fascicular arrangement of the spindle cells simulates the "streaming" phenomenon associated with @entity6 (IDH). This process also resembles the myoid, solid form of intraductal myoepithelial proliferation. The @entity0 ranged in age from 38 years to 79 years with a mean age of 59.3 years. Five @entity0 presented with a palpable mass. The remaining @entity2 were discovered using mammography. The radiological appearances of the lesions raised concern for @entity3 , but there were no distinctive mammographic findings to suggest an unusual variant of DCIS. Cytological preparations were suspicious for @entity2 in two @entity0 and were reported as malignant in another case. Sixteen @entity0 were treated with wide local excision, and one @entity0 had a partial mastectomy. The @entity2 measured from 3 mm to 15 mm (mean 8.65 mm). In three cases, minute foci of stromal invasion were associated with the spindle cell DCIS. In another specimen, a 2.7-cm @entity4 of no special type was identified in an area away from the foci of the spindle cell DCIS. None of the @entity0 has experienced recurrence or @entity1 during the relatively short mean follow-up period of 16.2 months (range 4-77 months). Spindle cell DCIS is distinguished from the streaming pattern of ordinary IDH by its solid growth pattern, lack of secondary spaces or peripheral fenestrations, uniformity of appearance and distribution of nuclei, cytological atypia in the range of low to intermediate-grade DCIS, and negative immunoreaction with CK-34betaE12 (HMW-CK903). When fenestrations are present, they are evident in areas of cribriform DCIS that merge with the solid, spindle cell areas in hybrid ducts harboring both patterns. This admixture, with conventional cribriform DCIS, and the association with foci of @entity4 in some cases further help recognition and confirmation of this lesion as in situ @entity3 . When there is no transition from the spindle cells to recognizable cribriform DCIS, distinction from @entity5 (myoepitheliosis) requires immunostains for actin and @entity7 protein. Recognition of this pattern of DCIS is important in order to avoid its frequent misclassification as a benign lesion.

title: @entity4 in situ. An unusual variant of XXXX that simulates @entity5 or a myoepithelial proliferation.

answer: @entity2


abstract: We assessed effects of passive sensitization on @entity0 bronchial smooth muscle (BSM) response to mechanical stretching in vitro. Bronchial rings were sham (control) or passively sensitized overnight by using sera from donors demonstrating sensitivity to @entity2 and having immunoglobulin E ( @entity3 ) concentrations of 2,600 +/- 200 U/ml. Tissues were fixed isometrically to force transducers to measure responses to electrical field stimulation (EFS) and quick stretch (QS). The myogenic response to QS was normalized to the maximal response to EFS (%EFS). The myogenic response of sensitized BSM was 47.9 +/- 10.9 %EFS to a QS of approximately 6.5% optimal length (Lo); sham-sensitized tissues had a myogenic response of 13.5 +/- 6.4 %EFS (P = 0.012 vs. passively sensitized). A QS of approximately 13% Lo in sensitized BSM caused a response of 82.8 +/- 20.9 %EFS; sham-sensitized tissues developed a response of 38.2 +/- 17.3 %EFS (P = 0.004). BSM incubated with serum from nonallergic donors did not demonstrate increased QS response (4.6 +/- 1.4 %EFS, P = not significant vs. tissue exposed to @entity1 ). However, tissues incubated in sera from nonatopic donors supplemented with hapten-specific chimeric @entity3 (JW8) demonstrated augmented myogenic response to QS of approximately 6.5% Lo (21.9 +/- 6.2 %EFS, P = 0. 027 vs. nonatopic sera alone). We demonstrate that passive sensitization of @entity0 BSM preparations causes induction and augmentation of myogenic contractions to QS; this hyperresponsiveness corresponds to the @entity3 concentration in sensitizing sera.

title: Passive sensitization of XXXX airways induces myogenic contractile responses in vitro.

answer: @entity0


abstract: OBJECTIVE: To investigate the neuromuscular activity of the gastrointestinal tract by antroduodenal manometry in @entity0 with @entity1 documented by laparoscopy, to assess the effects of diet and drug therapy on symptoms, and to assess the @entity15 that is commonly associated with these @entity2 . DESIGN: Prospective, open-label study. SETTING: A clinical center for the care of @entity0 's health. @entity0 (S): Fifty @entity0 with @entity1 documented by laparoscopy and @entity3 characterized by chronic @entity7 , @entity4 , @entity5 , early satiety, bloating and distention, and altered bowel habits. INTERVENTION(S): Motility of the gastrointestinal tract was recorded and @entity15 was assessed. Treatment consisted of dietary changes, including reduction of glycemic @entity11 , balancing with omega 9 oils, elimination of foods with @entity13 and @entity14 , and addition of @entity16 , as well as drug therapy with @entity9 (0.25 mg 3 times per day). RESULT(S): All 50 @entity0 showed a characteristic motility change (ampulla of @entity10 , a @entity6 equivalent of the enteric nervous system). Forty of the @entity0 showed @entity15 . There was a significant reduction in the total symptom score after 8 weeks of treatment. CONCLUSION(S): This study suggests that @entity1 and @entity3 are a result of the dysfunction of hollow organs. Correction of the biochemical imbalance of the eicosanoid system and the hypersecretion of insulin that results from excessive intake of glycemic @entity11 and lack of essential @entity8 significantly decreases symptoms in @entity0 with @entity1 and associated @entity12 of the gastrointestinal tract.

title: Relation of XXXX of the gastrointestinal tract: new insights.

answer: @entity12


abstract: BACKGROUND: The majority of @entity0 with @entity7 ( @entity7 ) are curable with standard therapy. The molecular differences between curable and incurable disease are unknown. We have studied the expression of @entity6 and the @entity4 ( @entity4 ) to determine their incidence in @entity3 . @entity0 AND METHODS: We retrospectively analyzed 23 @entity0 with chemorefractory non-seminomatous @entity7 (15 late relapse and eight transformed @entity2 ). None of these 23 @entity0 were cured by their initial chemotherapy and/or surgery. Immunohistochemical analysis of @entity6 and @entity4 was performed on the most recently available specimen from a metastatic site. PCR amplimers of @entity6 exon 17 were screened for mutations by a combination of denaturing high-performance liquid chromatography and direct sequencing. RESULTS: @entity6 was expressed (>/=10% of the @entity1 displaying membranous or cytoplasmic staining) in 11 of 23 @entity5 @entity0 [48%; 95% confidence interval (CI) 26% to 68%]. There were no activating @entity6 mutations in the phosphoryltransferase domain (exon 17) in 21 @entity0 analyzed. @entity4 was expressed (1+ to 3+) in 15 of 23 @entity5 @entity0 (65%; 95% CI 41% to 82%). CONCLUSIONS: @entity6 and @entity4 are expressed in a significant proportion of refractory @entity7 . The significance of these findings will be determined by ongoing clinical trials.

title: Expression of @entity6 and XXXX in chemotherapy refractory non-seminomatous @entity7 .

answer: @entity4


abstract: STUDY OBJECTIVE: To determine whether changes in serum @entity4 , serum @entity6 , and plasma @entity7 levels are correlated in a cohort of @entity3 @entity0 . DESIGN: Prespecified subgroup analysis of results from a prospective, multicenter, randomized, open-label, parallel-group study. Setting. Primary care clinics at three tertiary care medical centers. @entity0 : Community-based ambulatory population of 202 @entity0 (age range 17-65 yrs) with a new diagnosis of @entity3 , untreated @entity3 , or known @entity3 , who were previously treated with fewer than three antihypertensive drugs and had no evidence of @entity2 or @entity1 . Intervention. Monotherapy with oral @entity5 12.5 or 25 mg/day for 9 weeks. MEASUREMENTS AND MAIN RESULTS: Fasting serum @entity4 , serum @entity6 , and plasma @entity7 levels were obtained at baseline (before @entity5 therapy was started) and after 9 weeks of therapy. Significant elevations were noted in fasting serum @entity4 (mean +/- SD 3.42 +/- 10.38 mg/dl, p<0.0001) and plasma @entity7 (2.35 +/- 9.47 microU/ml, p<0.0001) levels, and a significant reduction in serum @entity6 level (0.30 +/- 0.44 mEq/L, p<0.0001) was noted. No significant correlation was observed between changes in fasting serum @entity4 and @entity6 levels (r = 0.022, 95% confidence interval (CI) -0.120-0.164, p=0.757) or between changes in serum @entity6 and plasma @entity7 levels (r = -0.112, 95% CI -0.256-0.037, p=0.140). Changes in serum @entity4 levels did not differ significantly between patients maintaining serum @entity6 levels of 4.0 mEq/L or greater and those with levels below 4.0 mEq/L. CONCLUSION: Changes in serum @entity6 and serum @entity4 levels were not correlated in individuals receiving @entity5 monotherapy; thus maintenance of normal @entity6 levels may not attenuate the risk of @entity9 diuretic-induced @entity8 .

title: Lack of correlation between @entity9 -induced XXXX and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.

answer: @entity8


abstract: Because @entity2 is triggered by several parallel mechanisms, a combination of drugs active against individual death-promoting mechanisms may have synergistic effects. @entity5 is a noncompetitive @entity1 antagonist with anti-inflammatory effects and @entity6 is a @entity7 antioxidant. Therefore, we explored whether their combined use results in smaller @entity3 volumes as compared with their individual administration. @entity0 underwent @entity4 ( @entity4 ) and were given vehicle, @entity5 alone, @entity6 alone, or a combination of @entity5 and @entity6 (n = 13 per group) 1 h later. Five animals in each group were evaluated with a motor rating scale 24 h after @entity4 and the @entity3 volumes were then measured. The remaining animals were examined with motor and behavioral scales up to 30 days after @entity4 and their @entity3 volumes were then determined. Motor disability and water maze latencies at all time points examined and @entity3 volumes at days 1 and 30 were significantly reduced in all active treatment groups when compared with vehicle. However, no significant differences were observed between the active treatment groups. In conclusions, combination therapy with @entity5 and @entity6 does not appear to have additional neuroprotective effects compared to those conferred by each agent alone even when administered at optimal timing and dosing. Therefore, a ceiling neuroprotective effect that is impossible to overcome may exist.

title: Combination of @entity5 and XXXX in focal cerebral ischemia: is there a ceiling effect?

answer: @entity6


abstract: The feasibility of medical control of and prevention of uterine @entity5 secondary to @entity10 by the induction of prolonged @entity13 with @entity4 was investigated. 29 @entity0 were treated during a 30-month period. Mean age was 25.7 years and mean parity was 1.8. @entity6 and @entity14 were the most frequently primary diseases. @entity2 , @entity7 , and @entity12 were also diagnosed. In 23 @entity0 @entity9 had an unfavorable effect on the primary illness and in 14 it was present when treatment began. All platelet counts were very low. 3 drug regimens were used: 1) @entity15 + @entity16 , 2) @entity17 ( @entity18 ), and 3) @entity18 + conjugated @entity3 . Significant @entity11 occurred in 7 @entity0 (24%) and was not related to the degree of @entity8 . Average length of treatment was 15.3 weeks. During the study 18 @entity0 died of their @entity1 . Treatment was discontinued in 7 because of improvement in the @entity1 . In 4 treatment is being continued. As @entity18 is released slowly, in 10 urgent cases iv conjugated @entity3 were given until @entity5 was controlled or @entity17 was given orally for a few days. Results show the feasibility of this method of producing therapeutic @entity13 in the management of a variety of @entity10 . Fluid retention was more frequent with high @entity3 dosage.

title: Therapeutic @entity13 in XXXX .

answer: @entity10


abstract: Alternative RNA splicing can be regulated in a highly cell- and tissue-specific or developmentally specific manner. In neurons, the functions of many gene products, such as those of @entity3 genes are regulated by alternative splicing. In this paper the mechanism of neural-specific RNA splicing is investigated using @entity3 genes as models. First, we confirm the splicing patterns of @entity3 transcripts during neural differentiation of P19 @entity0 ( @entity0 ) cells. The full-length form of @entity4 was expressed in the neuronal state. In contrast, both the full-length and truncated forms of @entity3 C were expressed constitutively in all differentiation states. However, two alternatively spliced forms with either 42- or 117- @entity1 insertions in the @entity2 kinase domain were detected only in the neuronal state. Thus, the expression of functional @entity4 and C was found to be regulated by alternative splicing during neural differentiation. To examine the molecular basis of neural-specific splicing, and how splicing regulation is modulated in different neurons. The expression of a number of general splicing factors was studied. The mRNA levels of the splicing factors @entity5 , U2AF SF3a, @entity6 and @entity7 was found to decrease rapidly during differentiation. In contrast, Nova, an RNA-binding protein was expressed in the neuronal state. We also found that the levels of two SR proteins, members of a family of splicing factors, increased in the neuronal state. These results suggest that the stoichiometric balance among some splicing factors, including SR proteins, may be associated with the alternative splicing of @entity3 transcripts during differentiation.

title: Changes in pre-mRNA splicing factors during neural differentiation in P19 XXXX cells.

answer: @entity0


abstract: OBJECTIVE: Tubal lesions detected in specimen of risk reducing salpingo oophorectomy (RRSO) for mutation @entity6 seems to play a @entity2 . The main objective of this study is to evaluate the prevalence of occult @entity1 , of @entity3 ( @entity3 ), and signature @entity4 in a cohort of @entity0 who underwent a risk reducing salpingo oophorectomy. METHODS: From January  2010 to January  2014 unicentric, retrospective study on a consecutive cases cohort of RRSO for @entity0 with a high risk of @entity2 (mutation @entity6 or family history). Pathological specimen should be analysed according to the SEE-FIM protocol. RESULTS: Ninety-three RRSO were recorded. Among them, 44% of the @entity0 had the germ line mutation @entity5 , 30.1% BRAC2 and 18.2% had no identified mutation. In all, 33.3% of the RRSO reveal a signature @entity4 , in the fimbria for 93.9%, 7.9% of them were bilateral. 1,1    (n=1) of the @entity0 presented a unilateral @entity3 . We obtained 4.3% of occult neplasia: 3  ovarian high-grade serous @entity3 and 1  tubal high-grade @entity3 . Only the tubal @entity3 coexists with @entity3 . CONCLUSION: 5,4% of the @entity0 who underwent RRSO had a diagnostic of occult @entity1 . One percent of the @entity0 had an isolated @entity3 . These results agree with recent data of the literature. Extensive examination of the Fallopian tube opens up a new way to understand @entity2 .

title: [Early epithelial lesions in prophylactic annexectomies in XXXX at high risk of @entity2 : Report of a series of 93  cases].

answer: @entity0


abstract: The safety and effectiveness of @entity13 plus @entity5 was evaluated in an open study of 43 @entity0 with community-acquired lower @entity10 . The mean age of the 28 @entity0 in whom bacteriologic evaluations were possible was 55 years; at least two thirds of the @entity0 had a history of @entity8 or @entity9 . A pathogen was isolated from sputum samples in 23 @entity0 ; five of these 23 also had documented @entity11 . There were five additional cases of @entity11 associated with clinical signs and symptoms of @entity1 but with no organisms isolated from sputum cultures. Thirty-five pathogens were isolated from the 33 evaluable @entity2 sites, primarily @entity3 and @entity14 . @entity12 was the causative organism in all 10 cases of @entity11 . @entity13 plus @entity5 (3 g of @entity13 and 100 mg of @entity5 ) was administered intravenously for a mean of six days. All 35 organisms isolated before treatment were eradicated. In one @entity0 a superinfection with @entity4 developed after treatment with @entity13 plus @entity5 . A clinical evaluation was possible for 32 of the 33 @entity2 sites; clinical cure was achieved at 31 sites and improvement was seen at the other site. All 43 @entity0 were monitored for adverse reactions by both clinical observation and laboratory tests. In one @entity0 , reversible @entity6 developed that required discontinuation of @entity13 plus @entity5 . In another @entity0 , there was a slight decrease in the @entity7 level during therapy. No systemic adverse reactions occurred, nor was there any instance of local effects associated with the intravenous infusion of the drug.

title: Safety and effectiveness of @entity13 plus XXXX in treatment of lower @entity10 .

answer: @entity5


abstract: BACKGROUND: @entity0 with moderate-to-severe @entity1 ( @entity1 ) often require photo- or systemic immunomodulatory therapies to induce disease remission and maintain long-term control. The current evidence to guide clinical management is small, despite the frequent and often off-label use of these treatments. Registries of @entity0 on photo- and systemic immunomodulatory therapies could fill this gap, and the collection of a core set concerning these therapies in @entity1 will allow direct comparisons across registries as well as data sharing and pooling. Using an eDelphi approach, the international TREatment of @entity1 (TREAT) Registry Taskforce aims to seek consensus between key stakeholders internationally on a core set of domains and domain items for @entity1 @entity0 registries with a research focus that collect data of @entity0 and adults on photo- and systemic immunomodulatory therapies. METHODS/DESIGN: @entity0 from six stakeholder groups will be invited: doctors, nurses, non-clinical researchers, @entity0 , as well as industry and regulatory body representatives. The eDelphi will comprise three sequential online rounds, requesting @entity0 to rate the importance of each proposed domain and domain items. @entity0 will be able to add domains and domain items to the proposed list in round 1. A final consensus meeting will be held with representatives of each stakeholder group. DISCUSSION: Identifying a uniform core set of domains and domain items to be captured by @entity1 @entity0 registries will increase the utility of individual registries, and provide greater insight into the effectiveness, safety and cost-effectiveness of photo- and systemic immunomodulatory therapies to guide clinical management across dermatology centres and country borders. TRIAL REGISTRATION: Not applicable. This eDelphi study was registered in the Core Outcome Measures for Effectiveness Trials (COMET) database.

title: TREatment of XXXX (TREAT) Registry Taskforce: protocol for an international Delphi exercise to identify a core set of domains and domain items for national @entity1 registries.

answer: @entity1