abstract: @entity1 risk is associated with excess body weight and elevated plasma free @entity5 ( @entity6 ) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma @entity6 profiles in the context of @entity3 , and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 @entity0 (BMI 30-39.9   kg/m(2)) 25-65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual @entity6 and plasma lipid concentrations were measured before and after @entity3 . Body weight, BMI, fat mass, total @entity2 , LDL-C and @entity4 concentrations decreased (P < 0.05) in both groups. Total @entity6 concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, @entity6 concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, @entity3 with an ADF diet decreases @entity6 concentrations through potentially different mechanisms.

title: Effects of @entity3 via high fat vs. low fat alternate day fasting diets on free XXXX profiles.

answer: @entity5


abstract: Telomere length maintenance is essential for tumorigenesis; most @entity0 @entity1 stabilize their chromosome ends via the activity of a specialized reverse transcriptase, telomerase, that uses the template region of the RNA moiety complementary to the TTAGGG repeat to synthesize one strand of telomeric DNA. @entity2 are estimated to constitute between 13% and 26% of primary @entity1 . The aim of this study was to evaluate telomerase activity and its messenger expression in @entity2 in relation to their different histologic pattern and grade of cytonuclear atypies, which are associated with relapse, and consequently represent the most important parameter for the evaluation of the clinical behavior of this @entity1 . Telomerase activity was examined by the telomeric repeat amplification protocol (TRAP) assay in 32 @entity2 (26 typical and 6 atypical/anaplastic). Telomerase messenger expression ( @entity3 mRNA) was evaluated by reverse transcription-PCR analysis in the same group of @entity1 . Telomerase activity ranged from undetectable to low levels in 19/26 (73%) of @entity2 , while all the atypical/ @entity2 showed medium-high levels of activity (>3 TPG units, median value), (chi(2) test; p=0.001). The levels of telomerase in terms of its messenger level expression overlapped the activity; a significant association between telomerase activity and @entity3 mRNA expression was also found (chi(2) test; p=0.01). Moreover, 2 atypical/ @entity2 of our series relapsed; in these samples we found high levels of telomerase, both in terms of activity and mRNA expression. Telomerase activity and its @entity3 mRNA expression tended to increase as the histologic grading of @entity1 increased, suggesting a role of telomerase reactivation in the progression of these @entity1 . Moreover, our results indicate RT-PCR assay as a rapid tool to identify and quantify telomerase RNA in @entity2 as in other @entity0 @entity1 models.

title: Telomerase in XXXX .

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVES: The traditional 4-tiered @entity2 ( @entity2 ) is widely accepted as histopathological classification for @entity3 ( @entity3 ) and has shown prognostic value. As intra- and inter-observer agreement are sub-optimal, simplified 2- or 3-tiered FGSs have been proposed. We aimed to validate these simplified 2- or 3-tiered FGSs for prediction of @entity1 -specific mortality (CSM) in a large study population from 2 European tertiary care centers. METHODS: We identified and followed-up 2415 @entity0 with @entity3 who underwent radical or partial nephrectomy in 2 European tertiary care centers. Univariable and multivariable analyses and prognostic accuracy analyses were performed to evaluate the ability of several simplified FGSs (i.e. grades I  +  II vs., grades III  +  IV, grades I  +  II vs. grade III and grade IV) to predict CSM. RESULTS: Independent predictor status in multivariate analyses was proved for the simplified 2-tiered @entity2 (high-grade vs. low-grade), for the simplified 3-tiered @entity2 (grades I  +  II vs. grade III and grade IV) as well as for the traditional 4-tiered @entity2 . The prognostic accuracy of multivariable models of 77% was identical for all tested models. Prognostic accuracy of the model without FG was 75%. CONCLUSIONS: A simplified 2- or 3-tiered @entity2 could predict CSM as accurate as the traditional 4-tiered @entity2 in a large European study population. Application of new simplified 2- or 3-tiered @entity2 may reduce inter-observer-variability and facilitate clinical practice without compromising the ability to predict CSM in @entity3 @entity0 after radical or partial nephrectomy.

title: Critical analysis of a simplified Fuhrman grading scheme for prediction of @entity1 specific mortality in XXXX with @entity3 - Impact on prognosis.

answer: @entity0


abstract: BACKGROUND: Two treatments, ranibizumab and @entity3 implant, for @entity2 due to @entity1 ( @entity1 ) secondary to @entity4 ( @entity4 ) have recently been studied in clinical trials. There have been no head to head comparisons of the two treatments, and improvement measured as gain in Best Corrected Visual Acuity (BCVA) was reported using different outcomes thresholds between trials. To overcome these limitations, and inform an economic model, we developed a combination of a multinomial model and an indirect Bayesian comparison model for multinomial outcomes. METHODS: Outcomes of change from baseline in BCVA for @entity3 compatible with those available for ranibizumab, reported by 4 randomised controlled trials, were estimated by fitting a multinomial distribution model to the probability of a @entity0 achieving outcomes in a range of changes from baseline in BCVA (numbers of letters) at month 1. A Bayesian indirect comparison multinomial model was then developed to compare treatments in the Branch @entity4 (BRVO) and Central @entity4 (CRVO) populations. RESULTS: The multinomial model had excellent fit to the observed results. With the Bayesian indirect comparison, the probabilities of achieving >= 20 letters, with 95% credible intervals, at month 1 in @entity0 with BRVO were 0.191 (0.130, 0.261) with ranibizumab and 0.093 (0.027, 0.213) with @entity3 . In @entity0 with CRVO, probabilities were 0.133 (0.082, 0.195) (ranibizumab) and 0.063 (0.016, 0.153) ( @entity3 ). Probabilities of a gain in >= 10 letters in BRVO @entity0 were 0.500 (0.365, 0.650) v 0.459 (0.248, 0.724) and in CRVO @entity0 0.459 (0.332, 0.602) v 0.498 (0.263, 0.791) for ranibizumab and @entity3 treatments respectively. The comparisons also favoured ranibizumab at month 6 although changes to therapies after month 3 may have introduced bias. CONCLUSION: The newly developed combination of multinomial and indirect Bayesian comparison models indicated a trend for ranibizumab association with a greater percentage of @entity1 @entity0 achieving @entity2 than @entity3 at months 1 and 6 in a common clinical context, although results were not classically significant. The method was a useful tool for comparisons of probability distributions between clinical trials that reported events on different categorical scales and estimates can be used to inform economic models.

title: Indirect comparisons of ranibizumab and XXXX in @entity1 secondary to @entity4 .

answer: @entity3


abstract: STUDY OBJECTIVES: The objectives of the study were to investigate the effects of 36   h of @entity7 on the discrete mood states of anger, @entity3 , @entity2 , @entity4 , @entity5 , and vigour in healthy adolescents. METHOD: Twelve healthy adolescent @entity1 (six male), aged 14-18 years (M   =   16.17, standard deviation (SD)   =   0.83), spent three consecutive nights in the sleep laboratory of the Centre for Sleep Research: two baseline nights with 10-h sleep opportunities and one night of @entity7 . Every 2   h during wakefulness, they completed the Profile of Mood States - Short Form. Mood across two baseline days was compared to mood at the same clock time (0900   h to 1900   h) following one night without sleep. RESULTS: The subscales of @entity3 , anger, @entity4 , @entity2 , vigour, and @entity5 were compared across days. All mood states significantly worsened following one night without sleep. Females showed a greater vulnerability to @entity6 following @entity1 , with greater depressed mood and @entity7 only witnessed among female @entity0 . While both males and females reported more @entity7 , the magnitude of this effect was greater for females. CONCLUSIONS: This study provides empirical support for the notion that @entity1 can causally affect mood states in healthy adolescents, with females having heightened vulnerability. Understanding the detrimental effects of insufficient sleep during adolescence is important, as it is a stage where @entity6 are highly prevalent. These findings escalate the importance of promoting sleep for the well-being of adolescents at this critical life phase.

title: Sleep deprivation leads to XXXX in healthy adolescents.

answer: @entity6


abstract: UNASSIGNED: The analgesic effects of preoperative ultrasound-guided nerve blocks wear off after about 12  hours, leaving some @entity0 in @entity2 . Transdermal @entity5 concentrations peak at 12 to 24  hours after application and maintain this concentration for approximately 72  hours. We sought to determine whether combining the use of a transdermal @entity5 patch with either a @entity4 would improve @entity2 control in @entity0 undergoing foot and/or ankle surgery. Consecutive @entity0 in the no-patch control group (n  =  104) were enrolled from July 2011 to October 2011, and those in the treatment group (n  =  232) were enrolled from November 2011 to May 2012 and received a transdermal patch (4.125  mg/7.5  cm(2) releasing 25   g of @entity5 per hour) applied to their chest postoperatively. @entity2 was assessed using a visual analog scale at 6, 12, 24, and 48  hours after surgery. The primary outcome measure was the number of requests for additional @entity3 medication. @entity1 was requested by 49 of the 104 control @entity0 (47.1%) and 63 of the 232 treated @entity0 (27.1%; p  =  .002). The mean @entity2 scores were also lower in the treatment group, with a statistically significant difference (p  <  .05) at 12, 24, and 48  hours. Thus, @entity0 receiving a @entity5 patch combined with an ultrasound-guided nerve block required less supplemental analgesia to maintain @entity2 control than did those receiving a nerve block alone. In conclusion, a @entity5 patch is a useful adjunct to an ultrasound-guided nerve block in foot and ankle surgery.

title: XXXX Patches to Supplement Ultrasound-Guided Nerve Blocks for  Improving @entity2 Control After Foot and Ankle Surgery: A Prospective Study.

answer: @entity5


abstract: OBJECTIVE: To evaluate the diagnostic accuracy of clinical, laboratory, and ultrasound (US) imaging characteristics of thyroid nodules in assessing the likelihood of @entity1 . STUDY DESIGN: Data from 184 @entity0 and adolescents with thyroid nodules were evaluated and compared with respective cytologic/histologic outcomes. A regression model was designed to assess the predictors associated with @entity1 and to calculate ORs. RESULTS: Twenty-nine @entity1 (25 papillary, 1 medullary, 3 @entity4 ), 8 follicular @entity3 , and 147 goitrous nodules (92 based on cytology, 55 on follow-up) were diagnosed. Fine-needle aspiration biopsy diagnostic accuracy, sensitivity, and specificity were 91%, 100%, and 88%, respectively. Male sex, compression symptoms, palpable lymphopathy, thyroid stimulating hormone concentration, microcalcifications, indistinct margins, hypoechoic US pattern, pathologic lymph node alterations, and @entity2 were associated with @entity1 . Regular margins, mixed echoic pattern, and peripheral-only vascularization were associated with benignity. During follow-up, nodule growth was associated with @entity1 , especially with @entity5 therapy. A multivariate analysis confirmed that microcalcifications, hypoechoic pattern, intranodular vascularization, lymph node alterations, and thyroid stimulating hormone concentration were independent predictors of malignant outcome. For each predictor, we provide sensitivity, specificity, and positive/negative predictive values. CONCLUSIONS: Clinical, laboratory, and US features of nodules can be used as predictors of @entity1 in @entity0 . Although none has diagnostic accuracy as high as that of fine-needle aspiration biopsy, these predictors should be considered in deciding the diagnostic approach of @entity0 with thyroid nodules.

title: Predictors of Malignancy in XXXX with Thyroid Nodules.

answer: @entity0


abstract: The @entity2 iceA gene was recently identified as a genetic marker for the development of peptic @entity1 in a Western population. To assess the significance of iceA subtypes of @entity2 in relation to peptic @entity1 , 140 Japanese clinical isolates (88 from Fukui and 52 from Okinawa) were characterized. Sequence analysis of the iceA1 gene from 25 representative Japanese strains was also carried out to identify the differences in iceA between the @entity1 group and the @entity3 group. The iceA1 genotype was not correlated with the presence of peptic ulceration in either area. In addition, sequence analysis led to identification of five deletions and five point mutations (a nonsense mutation or a 1-bp insertion) within the iceA1 open reading frame corresponding to previously published sequences. These mutations were identified in both clinical groups ( @entity1 and @entity3 groups) in each area. Local DNA sequence analysis revealed that the endpoints of all five deletions coincided with direct repeats. We also found four strains that carried longer iceA1 open reading frames compared with that for strain 60190. In conclusion, carriage of an iceA1 strain does not seem to be a risk factor for peptic @entity1 in Japanese subjects. The critical mutations in the iceA1 gene in some isolates from @entity0 with peptic ulcers suggested that IceA does not participate in the pathogenesis of peptic @entity1 in Japan. We also found deletion hot spots that were associated with direct repeats in iceA1 and that favored a small-deletion model of slipped mispairing events during replication. We showed that iceA1 sequence variations may be useful tools for analysis of the population genetics of @entity2 .

title: Sequence analysis and clinical significance of the iceA gene from XXXX strains in Japan.

answer: @entity2


abstract: The worldwide increase in @entity4 is a major challenge to the health care system and society. The proper treatment of @entity6 in the elderly is still controversial, and even more so from an international perspective. Optimising the treatment for improved outcomes and a reduced need for secondary surgery is mandatory for humanitarian and economical reasons. The importance of incorporating the @entity0 's perspective of the outcome in clinical trials has been acknowledged and there are now numerous instruments for assessing the quality of life. We evaluated two quality of life instruments, the EQ-5D and the SF-36, in @entity0 with @entity6 and also measured the quality of life two years after different interventions. The EQ-5D was validated in two prospective studies and it appeared to be an appropriate quality of life instrument in elderly @entity0 with @entity6 . There was a good correlation between the quality of life (EQ-5Dindexscores) and other outcome measures such as @entity3 , mobility and independence in activities of daily living (ADL). The results also showed high responsiveness, i.e., ability to capture clinically important changes, for both the EQ-5D and the SF-36. The questionnaire response rate for both instruments was high. The rated prefracture EQ-5Dindexscores showed good correspondence with the scores of an age-matched Swedish reference population. The quality of life in @entity0 with @entity6 treated with internal fixation (IF) decreased, particularly in @entity0 with @entity5 healing complications. The @entity5 healing complications rate at two years in @entity0 with displaced @entity6 treated with IF was 36% compared with 7% in @entity0 with undisplaced @entity5 . The quality of life of @entity0 with uneventfully healed @entity5 at two year was lower in @entity0 with primary displaced @entity5 than in @entity0 with primary undisplaced @entity5 . In a prospective randomised trial, @entity0 with displaced @entity6 were randomised to IF or total hip replacement (THR). IF resulted in more complications than THR, 36% versus 4%, and necessitated more reoperations, 42% versus 4%. Hip function and quality of life (EQ-5D) were generally better in the THR group. In summary, THR yielded a better outcome than IF for an elderly, relatively healthy, lucid @entity0 with a displaced @entity6 . In a study of elderly @entity0 with @entity6 , nearly half of the @entity0 displayed signs of @entity7 . Underweight was associated with @entity2 , @entity1 and a low quality of life (Nottingham Health Profile). In a prospective randomised trial, protein-rich liquid supplementation in combination with an anabolic steroid given for 6 months to lean elderly @entity0 after a @entity6 was shown to positively affect lean body mass, ADL and quality of life (EQ-5D). @entity5 healing complications had a negative impact on body weight, lean body mass and quality of life.

title: Quality of life and XXXX .

answer: @entity6


abstract: PURPOSE: To describe the ophthalmic findings of @entity1 of the orbit. METHODS: Prospective case series. Twenty-one @entity0 with @entity1 with orbital involvement underwent a complete ophthalmic examination and orbital imaging by CT. RESULTS: Four of the 21 @entity0 had @entity7 and 1 had @entity6 . In 17 @entity0 (81%), the disease was restricted to the craniofacial region. @entity5 , @entity3 were detected in 62% of the @entity0 . Nasolacrimal duct obstruction and strabismus were detected in only 1 and 2 @entity0 , respectively. Of the 34 orbits affected, the roof was affected in 67.6%. The floor was the least affected wall. For most orbits, the disease was seen in more than 1 wall, and in 9 orbits (26.5%) all 4 walls were involved. Twelve orbits (35.2%) showed cysts on CT within the affected bones. In 19 orbits (55.9%), the optic canal was circumferentially narrowed. Blindness was detected in only 1 @entity0 who had undergone optic canal decompression. CONCLUSIONS: The main consequences of orbital involvement in @entity1 are eye @entity9 and @entity8 . @entity2 is a common feature. Optic canal narrowing does not necessarily induce @entity4 . We believe that @entity0 with apical involvement should be carefully followed and have their apices decompressed only when their vision is clearly deteriorating. Our data do not support prophylactic optic canal decompression as a therapeutic measure.

title: @entity2 with XXXX : implications for vision.

answer: @entity1


abstract: BACKGROUND: Nasal @entity3 demonstrates histological features of epithelial remodeling and variable inflammatory cellular infiltration. We studied a large series of Chinese @entity1 ( @entity1 ) samples to characterize these histological features and their associations with clinical characteristics. METHODS: A detailed histological study of @entity3 was performed employing various histopathological techniques. A total of 153 intraoperative @entity1 biopsies were analyzed histologically. Sections were examined under microscopy to determine the percentages of different types of inflammatory cells, and types of epithelial remodeling. Two systems of subtyping NPs based on inflammatory cell infiltration were assessed. These were correlated with @entity0 characteristics. RESULTS: Epithelial remodeling patterns include @entity6 (87.8% of specimens), @entity2 (53.2%), and @entity4 (44.6%). Smoking was a strong independent association of @entity4 (adjusted odds ratio [OR] 9.9; 95% confidence interval [CI], 4.2 to 22.9; p < 0.01). The most common inflammatory cells were neutrophils (median of 12.8%) and CD8+ T cells (12.8%), followed by macrophages (11.0%), CD4+ T cells (9.7%), @entity5 (8.6%), and mast cells (7.6%). We defined 2 systems to classify NPs based on proportions of @entity5 and neutrophils. The majority of @entity1 samples were neutrophilic. The first classification system has greater histological correlation. Based on the first classification, @entity3 was associated with @entity6 (OR 3.7, p = 0.019) and @entity2 (OR 3.4, p < 0.001). CONCLUSION: The majority of Chinese NPs are neutrophilic and @entity6 is the most common pattern of epithelial remodeling. We show for the first time that smoking has a strong association with @entity4 in @entity3 .

title: Smoking is an independent association of @entity4 in Chinese XXXX .

answer: @entity1


abstract: PURPOSE: @entity2 ( @entity2 ) is the primary cause of @entity1 in preterm @entity0 . There are available data confirming that circulating endothelial progenitor cells (EPCs) are involved in forming the growing network of blood vessels in the developing retina. In this study we sought to explore potential relationship between concentration of circulating bone marrow-derived EPCs and development of @entity2 in prospective study. MATERIAL AND METHODS: The study groups consisted of 90 preterm (23-36 weeks of gestational age), and 52 full-term control @entity0 . EPCs were analyzed in cord blood (CB) and subsequently in peripheral blood (PB) in second and sixth week since delivery. The incidence and stage of @entity2 was prospectively documented in the preterm @entity0 . RESULTS: EPC concentration in CB was considerably higher in the preterm @entity0 developing @entity2 . In the preterm @entity0 a noticeable decrease in PB EPC concentration within six weeks of the follow up was found, whereas in full-term @entity0 EPC concentration was maintained at invariable level. Of note, in the sixth week since delivery, EPC concentration in preterm @entity0 with @entity2 was lower compared to preterm @entity0 without @entity2 . CONCLUSIONS: Increase in CB EPC concentration in preterm @entity0 , including those developing @entity2 , indicates that the circulating EPC cells contribute to the process of blood vessel formation, and their number in CB reflects the degree of @entity3 . Impaired blood vessel formation within retina in the course of @entity2 may result from decrease in circulating EPC number observed at the sixth week since delivery.

title: [The role of circulating endothelial progenitor cells in the progression of @entity2 of XXXX --a prospective study].

answer: @entity3


abstract: Background. @entity6 ( @entity6 ) are a group of @entity1 in which glycosylation required for proper protein-protein interactions and protein stability is disrupted, manifesting clinically with multiple system involvement and @entity3 . The insulin-like growth factor (IGF) system plays an important role in childhood growth and has been shown to be dysfunctional with low @entity2 levels in @entity0 with @entity6 type Ia ( @entity7 deficiency). Case report. A 3-year-old Caucasian male with failure to thrive was diagnosed with @entity7 - @entity6 at 5 months of age. Initially, his length and weight were less than -2 standard deviation score, @entity2 <25 ng/mL (normal 55-327 ng/mL), @entity5 1.0   g/mL (normal 0.7-3.6 ng/mL), and acid-labile subunit 1.3 mg/L (normal 0.7-7.9 mg/L). Despite aggressive feeding, he continued to show poor linear growth and @entity4 . At 17 months, he underwent an @entity2 generation test with growth hormone (0.1 mg/kg/d) for 7 days; baseline @entity2 of 27 ng/mL (normal 55-327 ng/mL) stimulated to only 33 ng/mL. Recombinant @entity0 @entity2 (rhIGF-1) therapy (up to 130   g/kg/dose twice daily) was initiated at 21 months of age resulting in an excellent linear growth response with height increasing from -2.73 to -1.39 standard deviation score over 22 months. @entity2 and @entity5 levels also increased. Conclusion. This is the first case report of rhIGF-1 therapy in a @entity0 with @entity7 - @entity6 . The @entity0 had an excellent linear growth response. These results provide additional in vivo evidence for IGF dysfunction in @entity7 - @entity6 and suggest that rhIGF-1 may be a novel treatment for @entity3 in @entity7 - @entity6 .

title: rhIGF-1 Therapy for Growth Failure and XXXX Deficiency in Congenital Disorder of Glycosylation Ia ( @entity7 Deficiency).

answer: @entity2


abstract: OBJECTIVE: Most @entity1 @entity0 become increasingly anxious toward the end of their life. The objective of this study was to identify predictors of increased opioid dosage in the last week of a @entity1 @entity0 's life. METHODS: We retrospectively reviewed charts of @entity0 who died in our palliative care unit. We assigned the @entity0 to increased group or decreased group according to changes in oral @entity4 equivalent dosage in their last 7 days. Logistic regression analysis was used to identify predictors of increased oral @entity4 equivalent dosage. RESULTS: We analyzed data of 158 @entity0 (female: 43.7%, median age: 64 years). The median oral @entity4 equivalent dosages on Days 7 and 1 before death were 50 mg (interquartile range: 24-122) and 61 mg (28-129), respectively. Independent predictors of increased oral @entity4 equivalent dosage included @entity5 (odds ratio: 11.5, 95% confidence interval: 4.98-28.83, P < 0.01), age <65 years (odds ratio: 2.3, 95% confidence interval: 1.04-5.26, P = 0.04) and oral @entity4 equivalent dosage <50 mg on Day 7 before death (odds ratio: 3.7, 95% confidence interval: 1.68-8.89, P < 0.01). The median oral @entity4 equivalent dosages on Days 7 and 1 before death were 48 mg (interquartile range: 20-126) and 75 mg (36-170) in @entity0 with @entity5 , and 50 mg (25-120) and 57 mg (25-124) in @entity0 with @entity3 , respectively. CONCLUSIONS: @entity5 , relative youth and oral @entity4 equivalent dosage <50 mg on Day 7 before death were predictive of increased oral @entity4 equivalent dosage in the last 7 days. Our findings may help oncologists to more accurately inform @entity0 about expected opioid requirements and thus relieve their end-of-life @entity2 .

title: XXXX , Relative Youth and Low Daily Doses of Opioids Predict Increased Opioid Dosage in the Last Week of a @entity1 @entity0 's Life.

answer: @entity5


abstract: OBJECTIVE: To explore the clinical effect of subtotal vertebrectomy, decompression and strut grafting in treating thoracolumbar burst @entity2 through @entity5 . METHODS: From May 2005 to July 2008, 14 @entity0 with thoracolumbar burst @entity2 were treated with subtotal vertebrectomy, decompression and strut grafting through @entity5 . There were 9 males and 5 females, ranging in age from 24 to 68 years, with an average of 42.3 years. All @entity0 were single segment @entity2 , of them, @entity9 was in 1 case, @entity10 in 5, L1 in 5 and L2 in 3. According to AO classification in spinal @entity2 , type A3 was in 5 cases, B1 in 3, B2 in 3, C1 in 2, C2 in 1. According to the ASIA classification in neurological function, grade A was in 3 cases, B in 3, C in 5, D in 2, E in 1. The height of anterior border vertebral body, volume of spinal canal and neurological function were analyzed by X-ray films, CT scanning and ASIA classification preoperative, postoperative and at final follow-up. RESULTS: Operative time was from 3.5 to 5.5 hours with the mean of 4.0 hours; @entity4 during operation was from 800 to 2 600 ml with the mean of 1 300 ml. Two cases with nerve @entity1 recovered without special handling after 3-6 months; 1 case with leakage of cerebrospinal fluid restored through lumbar cerebrospinal fluid drainage; 1 case with pleura tear healed through closed thoracic drainage. No @entity6 or @entity3 was found. The follow-up time was from 8 to 36 months with the mean of 16.5 months. All @entity0 had neurofunctional recovery at different degree, except that 3 @entity0 in grade A. The height of @entity7 restored from (42.25 +/- 11.87)% preoperatively to (94.38 +/- 3.08)% postoperatively, and (92.87 +/- 3.32)% at final follow-up (P<0.05); volume of spinal canal (the actual volume of spinal canal/normal volume of spine canal) increased from (45.63 +/- 6.88)% preoperatively to (95.26 +/- 3.31)% postoperatively, and (96.13 +/- 2.56)% at final follow-up (P<0.05). Cobb angle were corrected from (25.64 +/- 4.40) degrees preoperatively to (5.80 +/- 1.14) degrees postoperatively; Cobb angle lost from 0 degrees to 6 degrees at final follow-up with (8.10 +/- 2.65) degrees. All @entity0 obtained complete bony fusion without @entity8 formation at final follow-up. CONCLUSION: Subtotal vertebrectomy decompression and strut grafting through @entity5 is an effective and safe method in treating thoracolumbar burst @entity2 , which can restored height of intervertebral body, volume of spinal canal and physiological flexion of spinal column, and retain spinal permanent stability.

title: [Treatment of thoracolumbar burst XXXX with subtotal vertebrectomy, decompression and strut grafting through posterolateral approach].

answer: @entity2


abstract: UNASSIGNED: Respite workers (RW) commonly care for @entity0 with @entity3 ( @entity3 ), and @entity2 is common for these @entity0 . Little is known about factors which inform @entity2 assessment and management-related decisions. OBJECTIVES: To describe/determine the following in response to a series of @entity2 -related scenarios (e.g., @entity1 , falling): (1) factors considered important by RW when assessing @entity0 with @entity3 's @entity2 ; (2) whether @entity0 's verbal ability impacts @entity2 assessment factors considered; (3) RW assessment and management approach. @entity0 : Fifty-six RW (18-67 years, Mage=33.37, 46 female). PROCEDURE/MEASURES: In an online survey, @entity0 read and responded to six vignettes manipulating @entity0 verbal ability (verbal, nonverbal) and @entity2 source. RESULTS: The factors most frequently considered when assessing @entity2 were @entity0 behavior (range: 20-57.4%), and history (e.g., @entity2 , general; 3.7-38.9%). Factors did not vary by @entity0 's verbal ability. RW indicated varied assessment and management-related actions (range: 1-11) for each scenario. DISCUSSION: Findings suggest: a) factors informing @entity2 assessment did not depend on whether or not the @entity0 was verbal and b) a degree of flexibility in RW response to @entity2 across situations. While these findings are encouraging, ensuring RW have adequate @entity2 assessment and management knowledge specific to @entity0 with @entity3 is critical.

title: Caring for @entity0 with XXXX part 2: Detailed analyses of factors involved in respite workers' reported assessment and care decisions.

answer: @entity3


abstract: UNASSIGNED: The psychological impact of an unfavorable genetic test result for counselees at risk for @entity4 seems to be limited: only 10-20  % of counselees have @entity2 after testing positive for a known familial mutation. The objective of this study was to find prognostic factors that can predict which counselees are most likely to develop @entity2 after presymptomatic genetic testing. Counselees with a 50  % risk of @entity5 or @entity3 completed questionnaires at three time-points: after receiving a written invitation for a genetic counseling intake (T1), 2-3  days after receiving their DNA test result (T2), and 4-6  weeks later (T3). The psychological impact of the genetic test result was examined shortly and 4-6  weeks after learning their test result. Subsequently, the influence of various potentially prognostic factors on psychological impact were examined in the whole group. Data from 165 counselees were analyzed. Counselees with an unfavorable outcome did not have more @entity1 , but showed significantly more @entity0 worries 4-6  weeks after learning their test result. Prognostic factors for @entity0 worries after genetic testing were pre-existing @entity0 worries, being single, a high risk perception of getting @entity0 , and an unfavorable test result. @entity1 was best predicted by pre-existing @entity0 worries and pre-existing @entity1 . The psychological impact of an unfavorable genetic test result appears considerable if it is measured as "worries about @entity0 ." Genetic counselors should provide additional guidance to counselees with many @entity0 worries, @entity1 , a high risk perception or a weak social network.

title: Prognostic Factors for Distress After Genetic Testing for XXXX .

answer: @entity4


abstract: BACKGROUND: Campylobacter spp. has been identified as one of the leading causes of @entity3 in the world. In recent years, an increase was demonstrated in the incidence of campylobacteriosis in several countries, including Israel. The incidence rate of campylobacteriosis in Israel increased from 22.3 per 100000 in 1997 to 77.4 per 100000 in 2009. The aim of this study was to explore risk factors for @entity1 with Campylobacter among young @entity0 in Israel. METHODS: A matched case-control study was performed to investigate risk factors for sporadic @entity4 among 113 affected @entity0 1 to 5 years of age and 113 age-, gender- and neighborhood-matched controls. Information about exposure to potential risk factors was obtained via telephone interview and was evaluated by conditional logistic regression analysis. RESULTS: In the multivariable model, for each additional @entity2 meal consumed during the week before the onset of illness, the odds for @entity4 increased by 32% (adjusted matched odds ratios (aMOR)=1.32, 95%CI: 1.01-1.72, p-value=0.04) while consumption of fruits and vegetables decreased the odds for @entity4 by 97% (aMOR=0.03, 95%CI: 0.00-0.28, p-value<0.01), and for each additional @entity0 living in the household, the odds for @entity1 decreased by 48% (aMOR=0.52, 95%CI: 0.33-0.83, p-value<0.01). Using diaper increased the odds for campylobacteriosis (aMOR=7.36, 95%CI: 1.66-32.70, p-value<0.01). CONCLUSIONS: Interventions that focus on proper handling of @entity2 and @entity2 products, hand washing and encouraging consumption of fruits and vegetables could help in controlling Campylobacterinfections.

title: Risk Factors for Sporadic Infection with Campylobacter Spp. among XXXX in Israel: A Case-Control Study.

answer: @entity0


abstract: OBJECTIVES/HYPOTHESIS: Transtympanic @entity2 therapy has become a popular treatment modality for @entity4 , but questions regarding the ideal dose of medicine, the best administration paradigm, and the safest treatment end-point remain unanswered. The goal of this study is to examine the inner ear kinetics of transtympanic @entity2 and compare this with the kinetics of sustained-release delivery in a basic science model. In addition, we plan to examine the relationship of these kinetics curves to the effect of the two treatment modalities on inner ear function and morphology. It is hoped that this analysis will help clinicians to better apply local medical therapy to the ear. STUDY DESIGN: The study is a basic science project designed to examine perilymph @entity2 concentrations, hearing results, and inner ear morphology in an animal model. METHODS: @entity2 was applied to the right ear of chinchillas either through a transtympanic approach or in a sustained-release device. The left ear remained untreated as an internal control. At set time points the animals' hearing and balance function was studied and the perilymph was harvested, after which the animal was killed and preserved for histological evaluation. Kinetics curves were constructed for each of the two treatment paradigms and compared with histological and functional outcomes. RESULTS: The two groups yielded dramatically different kinetics curves. The transtympanic curve had a high peak level at 24 hours with rapid fall-off and almost total elimination by 48 hours, whereas the sustained-release curve was characterized by a long, flat plateau phase with a peak that was approximately one-third that of the transtympanic curve. In addition, the variability seen in perilymph concentrations was significantly higher in the transtympanic group than in the sustained-release group. Immunohistochemical analysis using antibodies against cleaved @entity1 and cleaved @entity5 demonstrated early damage in the @entity3 of both groups, before any obvious morphological change in the hair cells. The staining was significantly more dense in animals with transtympanic delivery. Cochlear and vestibular hair cell damage was seen at late time points in animals from both groups. @entity0 ( @entity0 ) progressed in an orderly fashion in the sustained-release group of animals, with no @entity0 seen in the early time points and universal significant threshold shifts present by 72 hours. In the transtympanic group, the @entity0 was more variable, with significant threshold shifts occurring as early as 4 hours after treatment, but with some animals demonstrating preserved hearing at the 72-hour time point. All animals demonstrated profound @entity0 at the 6-day time point. CONCLUSIONS: There is a significant difference in the shape and variability of the perilymph kinetics curve when comparing sustained-release delivery to transtympanic delivery of @entity2 . High early peak levels of @entity2 seen with transtympanic therapy may have a profound effect on the @entity3 and produce early @entity0 before obvious hair cell damage. Sustained delivery of @entity2 produces universal @entity0 at 72 hours. The reliability of sustained-release delivery to the ear reduces functional and morphological variations between animals.

title: Transtympanic versus sustained-release administration of XXXX : kinetics, morphology, and function.

answer: @entity2


abstract: Serial changes in @entity1 after anterior mitral valve repair were examined by transesophageal echocardiography (TEE) in 34 of 86 consecutive @entity0 with pure @entity1 who underwent anterior mitral valve repair from 1987 to 1996. The @entity0 were divided into two groups: 15 @entity0 undergoing mitral repair with @entity2 ( @entity2 ; @entity2 group) and 19 undergoing conventional mitral repair without @entity2 (non- @entity2 group). The @entity2 group included 11 @entity0 and 4 @entity0 with a mean age of 52.1 years. They were followed for mean 22.8 +/- 12.0 months. The non- @entity2 group included 12 @entity0 and 7 @entity0 with a mean age of 53.9 years. They were followed for mean 33.9 +/- 20.4 months. @entity1 jet areas were observed at the time of operation, 1 month after mitral valve repair, and in the late follow-up period. Regurgitation jet areas were 0.7 +/- 0.7, 1.1 +/- 0.9 and 2.5 +/- 2.1 cm2 in the @entity2 group, and 1.1 +/- 1.3, 2.4 +/- 1.7, 4.7 +/- 2.9 cm2 in the non- @entity2 group. The jet area was significantly smaller in the @entity2 group than in the non- @entity2 group at 1 month after operation and in the late follow-up period. Moderate to severe regurgitation was observed in two @entity0 (13.3%) in the @entity2 group, and eight @entity0 (42.1%) in the non- @entity2 group. Mitral valve repair with @entity2 showed better results than conventional mitral valve repair without @entity2 during the mean follow-up period of 23 months.

title: [Serial changes in XXXX after mitral valve repair with artificial chordae tendineae: assessment by transesophageal echocardiography].

answer: @entity1


abstract: This paper examines the spread of @entity2 from the Opening of Korea to the early Japanese colonial period. It focuses on the formation and expansion of Japanese settlement in Korea, the influence of wars, and the state control of VD. The Opening of Korea made the foreign settlement, and Japanese licensed prostitution flourished in Japanese settlement. According to the First Annual Report of the Korean Government Hospital (1886) and Gyelimuisa (1887), VD @entity0 occupied 18.3% of outpatients in Jejungwon hospital of Seoul and 8.9% of outpatients in Busan hospital. Directly after the Opening of Korea, Korean @entity0 's VD became lesser critical than Japanese @entity0 's VD. But the expansion of Japanese settlement and outbreak of two wars such as Sino-Japanese War and Russo-Japanese War made worse Korean @entity0 's VD. According to the Residency-General resources (1904-1909), @entity1 @entity0 was registered in 0.8-6.6% (average 3.6%). If it add to @entity3 and @entity5 @entity0 which often could not be found out by the naked eyes, the number of VD @entity0 will be increase. Ji Seok-yeong (1855-1935), the earliest @entity4 vaccinarian in Korea, asserted the need of VD control. Though he warned @entity0 bought sex as well as prostitutes became the main culprit of VD diffusion, he supported licensed prostitution because of realistic possibility. The Great Han Empire (1897-1910) tried to control the lower grade whore, and gathered prostitutes in some area by police power. After Japanese annexation of Korea, while Japanese has gradually decreased in VD @entity0 , Korean has gradually increased in VD @entity0 .

title: [Trade, wars and the XXXX : VD epidemic and control of Korea in the late nineteenth and early twentieth century].

answer: @entity2


abstract: AIM OF THE STUDY: We present the case of a @entity0 with @entity7 associated with @entity1 in the middle of philtrum at the upper lip. @entity0 AND METHODS: The @entity0 was supported from birth for @entity7 . Several procedures were performed in childhood to correct a @entity8 and @entity4 right. At 14 years old, she has a rhinoplasty to correct a complex nasal @entity2 . During the procedure, a hole in the upper central incisor inter-space is found. It is extended by a @entity1 which runs through the front palate towards the vomer rail at the base of the partition. This @entity1 is blind behind the vomer and can be completely resected. Pathological examination of the resection reveals a squamous lining. RESULTS: The median @entity1 of the upper lip are extremely rare  : less than 30 cases reported in the literature. The unusual run of the @entity1 and the recent appearance of a @entity5 in this @entity0 makes us look for a continuity between it and Rathke's pocket by computed tomography imaging type. CONCLUSION: The association of @entity7 and median @entity3 was never yet described in the literature. The association with @entity6 was suspected with the posterior extension of the @entity2 , not confirmed by the scanner, but strongly suspected jointly by the neurosurgical and plastic surgery team.

title: [Median XXXX associated with @entity7 : Report of a case].

answer: @entity3


abstract: OBJECTIVE: Evaluate TENS effectiveness as a complementary treatment of chronic @entity4 and @entity3 in @entity0 with @entity1 . STUDY DESIGN: This randomized controlled trial was performed in a tertiary health care center, including twenty-two @entity0 with @entity1 undergoing hormone therapy with persistent @entity4 and/or @entity3 . This study was registered in the Brazilian Record of Clinical Trials (ReBEC), under n RBR-3rndh6. TENS application for 8 weeks followed a randomized allocation into two groups: Group 1 - acupuncture-like TENS (Frequency: 8Hz, pulse duration: 250 s) - VIF (n=11) and Group 2 - self-applied TENS (Frequency: 85Hz, pulse duration: 75 s) (n=11). The intensity applied was "strong, but comfortable". We evaluated @entity0 before and after treatment by the use of the Visual Analogue Scale, Deep @entity3 Scale and Endometriosis Quality of Life Questionnaire. We used the Wilcoxon and Mann-Whitney tests to compare before and after treatment conditions. RESULTS: Despite the use of hormone therapy for 1.65  2.08 years, the 22 @entity0 with @entity1 sustained @entity4 complaints (VAS=5.95  2.13 and 2.45  2.42, p<.001) and/or @entity3 ( @entity5 =2.29  0.46 and 1.20  1.01, p=.001). We observed significant improvement for chronic @entity4 , @entity3 and quality of life by the use of TENS. Both application types of TENS were effective for improving the evaluated types of @entity2 . CONCLUSIONS: Both resources (acupuncture-like TENS and self-applied TENS) demonstrated effectiveness as a complementary treatment of @entity4 and @entity3 , improving quality of life in @entity0 with @entity1 regardless of the device used for treatment.

title: Effectiveness of XXXX treatment for @entity0 with @entity1 through Transcutaneous Electrical Nerve Stimulation (TENS): randomized controlled trial.

answer: @entity2


abstract: UNASSIGNED: @entity8 multisystem crisis is a rare and life-threatening disease that is associated with numerous symptoms and which is also difficult to diagnose. We herein report an autopsy case of a 61-year-old @entity0 who died due to @entity8 . The @entity0 complained of @entity3 and breathlessness. Computed tomography showed a shadow-like region with a similar appearance to @entity4 . The @entity0 was diagnosed with @entity6 induced by severe @entity2 based on the results of echocardiography and coronary angiography. The @entity0 was treated for @entity4 . However, his condition rapidly deteriorated and he died 6 hours after arrival. We were later informed of his extremely high @entity9 serum levels. We found @entity8 with @entity5 at autopsy. The @entity0 's lungs showed @entity7 with @entity1 and extravasation.

title: @entity8 Multisystem Crisis Behaving Like XXXX : An Autopsy Case.

answer: @entity4


abstract: UNASSIGNED:     OBJECTIVE: To explore the effect of glycated hemoglobin (HbA1c) and albumin-corrected glycated serum proteins ( @entity4 - @entity6 ) on the mortality of @entity1 @entity0 receiving continuous @entity3 ( @entity3 ).     METHODS: In this single-center retrospective cohort study, incident @entity1 @entity0 from January 1, 2006, to December 31, 2010, were recruited, and followed up until December 31, 2011. The effect of HbA1c and @entity4 - @entity6 on mortality was evaluated by Cox proportional hazards models.     RESULTS: A total of 200 @entity0 (60% male, mean age 60.3    10.6 years) with a mean follow-up of 29.0 months (range: 4.3 - 71.5 months) were recruited. Sixty-four @entity0 died during the follow-up period, of whom 21 died of @entity2 ( @entity2 ). Mean values for HbA1c, @entity6 and @entity4 - @entity6 were 6.7% (range: 4.1 - 12.5%), 202  mol/L (range: 69 - 459  mol/L), and 5.78  mol/g (range: 2.16 - 14.98  mol/g), respectively. The concentrations of @entity6 and @entity4 - @entity6 were closely correlated with HbA1c (r = 0.41, p < 0.001 and r = 0.45, p < 0.001, respectively). In multivariate Cox proportional hazards models, @entity0 with HbA1c >=  8% were associated with increased risk of all-cause mortality (hazard ratio [HR] = 2.29, 95% confidence interval [CI]: 1.06 - 4.96, p = 0.04), but no increased mortality in @entity0 with 6.0%  <= HbA1c  <= 7.9%. @entity0 with @entity4 - @entity6  <= 4.50  mol/g had increased all-cause and non-cardiovascular mortality (HR = 2.42, 95% CI: 1.13 - 5.19, p = 0.02; and HR = 2.98, 95% CI: 1.05 - 8.48, p = 0.04 respectively).     CONCLUSIONS: Increased @entity5 c and decreased @entity4 - @entity6 may be associated with poorer survival in @entity1 @entity0 , with a non-significant trend observed for poorer survival with the highest level of @entity4 - @entity6 .

title: The Effect of Glycated Hemoglobin and Albumin-Corrected Glycated Serum Protein on Mortality in @entity1 XXXX Receiving Continuous Peritoneal Dialysis.

answer: @entity0


abstract: This study was undertaken to investigate electrophysiological properties of immortalized SV40-transfected @entity0 corneal endothelial cells (HCEC-SV40) combined with the analysis of intracellular @entity1 responses mediated by ligands for receptor @entity5 kinases (RTK). In addition, the effects of several @entity5 kinase inhibitors were tested on @entity1 inflow mediated by induction of capacitative @entity2 entry (CCE). Patch-clamp techniques and measurements of the intracellular free @entity1 ([ @entity1 ](i)) by @entity3 were performed using HCEC-SV40. Stimulation of fibroblast growth factor receptors (FGFR) (e.g. by basic-FGF) (10 ng ml(-1)) elicited activation of @entity1 permeable channels and a subsequent increase of cytosolic free @entity1 in HCEC-SV40. This effect could be disrupted by the L-type @entity1 channel blocker @entity4 (5 microM). In addition, @entity4 significantly reduced the magnitude of CCE. Inhibition of protein @entity5 kinases (PTKs) by @entity6 , @entity7 , or @entity8 51 (all 5 microM) also led to a reduction of CCE in HCEC-SV40. This study demonstrates for the first time that L-type @entity1 channel activity in HCEC-SV40 is linked to the activity of FGF receptor @entity5 kinases. These data regarding @entity1 inflow through @entity1 channels could be useful for investigation of culture and vitality conditions of HCEC.

title: @entity2 influx induced by activation of receptor XXXX kinases in SV40-transfected @entity0 corneal endothelial cells.

answer: @entity5


abstract: UNASSIGNED: 9728 Background: To evaluate the age of presentation of @entity0 ( @entity0 ) and its correlation with the expression of @entity2 and hormonal receptors in Mexican @entity1 Methods: A descriptive analysis of 101 @entity1 with @entity0 was carried out in the Oncology Hospital 'Siglo XXI' during the year 2002-2003.Testing of herceptes and determination of hormonal receptors were correlated with the clinical stage and the @entity1 age. RESULTS: The average @entity1 age was 52 years (range 29-86), the most frequent clinical stage was stage III (58.41%). 26 @entity1 with @entity2 positive, 75 @entity1 @entity2 negative. 37 @entity1 with RE positive, 62 RE negative, 37 @entity1 with @entity3 positive and 61 with @entity3 negative. A description of the subgroups is detailed in the table below. [Figure: see text] Undeterminable = 2, non classification = 5 When correlating @entity2 /neu with hormonal receptors the following results were established: @entity2 positive is associated with RE negative (80.76%) and with RE positive (15.38%); @entity2 /neu negative is associated with @entity3 negative (84.61%), and with @entity3 positive (7.69%), with RE negative (54.60%), and with RE positive (44.00%). CONCLUSIONS: The age of presentation of @entity0 is at least 10 years earlier than in developed countries, the over-expression of @entity2 is similar to that reported in the literature, and in the same way the appearance of positive hormonal receptors is associated with under-expression of @entity2 . The RE and @entity3 are expressed in equal percentage in @entity1 with @entity2 negative. Environmental and inherent factors need studying in order to investigate the early appearance of @entity0 . No significant financial relationships to disclose.

title: Early appearance of @entity0 ( XXXX ) and its patterns of expression for @entity2 and hormonal receptors (HR).

answer: @entity0


abstract: UNASSIGNED: 236 Background: @entity0 (pts) with @entity3 are generally treated with curative intent and many become long-term survivors. There is little data on health behaviors after @entity6 diagnosis and their effect on QOL and long-term outcomes. METHODS: Lymphoma pts were prospectively enrolled within 9 months of diagnosis in the University of Iowa/Mayo Clinic SPORE Molecular Epidemiology Resource (MER) and systematically followed. We measured QOL (FACT-G) and health behaviors ( @entity5 / @entity4 use; diet/exercise habits) 3 years after diagnosis. For this study, "survivor" was defined as alive at 3 years from diagnosis with no active disease or treatment within the previous year. RESULTS: From 2002-2012, 671 @entity0 with @entity3 were enrolled, met survivor definition, and completed 3-year QOL and health behavior questionnaires. At 3-years, 31% of female (F) and 48% of male (M) reported a history of @entity5 use for 6+ months. Of these, 13% of F and 7% of M were still smoking; 52% reported decreased use from baseline. 66% reported no change in @entity4 intake at 3-years while 25% of F and 34% of M reported decreased intake. 60% often chose whole grains and 65% get 2+ servings of vegetables daily. 42% of F and 38% of M "somewhat" believed diet could change the course of their @entity6 . Most pts endorsed no significant change in diet as a result of diagnosis. Those who made changes did so primarily out of concern for "health problems other than @entity1 ". Overweight/ @entity2 responders were 72% pre- and 66% post-treatment. A desire to lose weight was reported by 55% of pts. 14% of F and 23% of M often engaged in regular physical activity (PA). Nearly 50% reported a decrease in PA. Pts with advanced stage (p = 0.006), age > 60 (p = 0.001), ECOG PS > 2 (p = 0.04), and worse prognostic score (p = 0.006) were more likely to report decreased PA since diagnosis. 68% of F and 61% of M intend to become more active in the next months. Regular PA (p = < 0.0001) was associated with higher QOL, while increased @entity4 intake was associated with lower QOL (p = 0.009) at 3 years. CONCLUSIONS: Many survivors of aggressive @entity7 strive to adopt healthy behaviors and these behaviors are associated with higher QOL. Interventions aimed at emphasizing these behaviors may have potential to improve long-term outcomes and QOL.

title: Health behaviors in survivors of aggressive XXXX .

answer: @entity7


abstract: OBJECTIVE: @entity1 are highly prevalent in population of European countries. However, the effect of @entity3 ( @entity3 -chrono) on @entity1 ( @entity1 ) has not been studied in a double-blind placebo-controlled design. METHOD: Eighty @entity0 (all @entity0 ) were washout from the all medications. Each @entity0 was randomized to receive either @entity3 -chrono (40 @entity0 ) for 6 weeks or matched placebo (40 @entity0 ) in a double-blind manner. Eligible @entity0 , in addition to meeting the DSM-IV criteria for @entity1 and having a minimum score of 25 and more on the Hamilton Anxiety Scale, were required to be between 18 and 65 years. Response was defined as a 50% reduction in the Hamilton anxiety scale score. Response and side effects with @entity3 -chrono and placebo were compared by using analysis of variance (ANOVA) and chi-square tests. Six @entity0 did not return for at least one subsequent assessment, leaving 74 @entity0 (36 taking @entity3 -chrono and 38 taking placebo) in the valuables study group. RESULTS: Twenty six of the 36 @entity3 -chrono-treated @entity0 responded by 6 weeks, versus six of the 38 placebo-treated @entity0 (p<0.001). The most common and problematic side effect in the @entity3 -chrono group was @entity4 and @entity2 . CONCLUSIONS: The authors believe this to be the first double-blind placebo-controlled randomization study to test the efficacy of a @entity3 -chrono in the management of @entity1 . They need to be replicated in a larger study group.

title: @entity3 ( XXXX -chrono) in the acute treatment of outpatients with @entity1 without psychiatric comorbidity: randomized, double-blind placebo-controlled study.

answer: @entity3


abstract: Allergen-induced inhibition of pulmonary surfactant in @entity3 may promote @entity1 and consequently potentiate the severity of the @entity4 response. A randomised, single-blind, cross-over study of an inhaled synthetic phospholipid dry-powder surfactant (Pumactant) was conducted in atopic, @entity4 subjects with previously documented early and late @entity4 responses (EAR and LAR) to an inhaled allergen. This was conducted to evaluate the role of exogenous surfactant administration on EAR and LAR. A total of seven subjects had complete evaluable data and received the full dose of Pumactant. Asthmatic subjects inhaled two separate doses of 400 mg Pumactant prior to an allergen exposure. The first dose was administered 8 h in advance and the second dose 30 min in advance. The dosage occurred through a purpose-built administration device. This was followed by a standard bronchial-provocation test, and forced expiratory volume in one second (FEV1) was measured at regular intervals over a 10-h period. Pumactant was well tolerated and, surprisingly, abolished the EAR but not the LAR in all seven subjects. The mean area under the curve between 0-2 h (EAR) following bronchial provocation test was 0.08 for the Pumactant treatment group (PT) and 13.29 for the no treatment (NT) group. The maximum drop in FEV1 for EAR was 4.19% and 23.98% in the PT and the NT group, respectively. The demonstration of inhibition of the early @entity4 response by exogenous surfactant, provides the first evidence that pulmonary surfactant dysfunction may also contribute to the very early @entity4 response to allergen. Exogenous surfactant administration could serve as a useful adjunct in controlling the early allergen-induced symptoms in @entity0 with @entity2 .

title: Inhaled synthetic surfactant abolishes the early allergen-induced response in XXXX .

answer: @entity3


abstract: OBJECTIVES: To evaluate the use of contrast-enhanced helical computed tomography (HCT) scanning with three-dimensional reconstructions as a possible identifier of crossing vessels in ureteropelvic junction (UPJ) obstruction. Endoscopic treatment of @entity2 has a success rate that approaches 90%. These results drop to 40% in the presence of crossing vessels. Unrecognized crossing vessels can also result in significant @entity1 during endopyelotomy. The presence of crossing vessels is, for many, an indication for open or laparoscopic UPJ repair. Therefore, accurate preoperative imaging is crucial for appropriate treatment planning. METHODS: Our study population consisted of 18 @entity0 evaluated and treated for @entity2 at the University of Michigan Health System. These @entity0 underwent routine contrast-enhanced preoperative HCT scanning before UPJ repair. A prior history of failed endoscopic treatment, @entity0 preference, and HCT findings of crossing vessels were indications for open or laparoscopic repair. The imaging findings were compared with open findings during laparoscopic or open pyeloplasty. RESULTS: An HCT finding of the presence of crossing vessels was a significant positive predictor, with a value of 100%. The sensitivity in this population was 91% and the specificity was 100%. No difference was noted between the detection of arterial or venous crossing vessels. The positive predictive value was 100%, and the negative predictive value was 88%. CONCLUSIONS: HCT is an accurate predictor of the presence of crossing vessels in @entity2 . Because crossing vessels may have a profound impact on treatment outcome, HCT can serve as an effective, noninvasive, preoperative screening tool.

title: Helical computed tomography for identification of crossing vessels in XXXX with operative findings.

answer: @entity2


abstract: Aim of this study is to determine the expression of apoptosis and @entity3 ( @entity3 ) in the cardiac conduction system in @entity4 and @entity1 ( @entity1 ) cases. Postnatal morphogenesis of the conducting tissue is an important part of its normal development. In the atrio-ventricular node (AVN) and His bundle (HB) it consists of @entity1 and replacing in an orderly programmed way. However, its nature and its relation to @entity4 is not yet fully explained. Apoptosis and @entity3 were investigated in 8 heart conduction systems of @entity0 dying of @entity4 and in 3 conduction systems of @entity0 dying of @entity1 as controls. The cardiac conduction system was removed in two blocks: the first included the sino-atrial node (SAN) and the crista terminalis, the second contained the atrio-ventricular node (AVN), His bundle (HB), bifurcation, and bundle branches. In the conduction systems as well as in the common myocardium the @entity3 Labeling Index ( @entity3 -LI) was found to be negative in all cases. The apoptotic indices (AI) in @entity4 and in @entity1 were found to have no statistically significant differences (p>0.05). The SAN, in both groups, showed an AI similar to the one detected in common myocardium. In almost all cases, TUNEL labeling was detected in peripheral region of the AVN, close to the @entity2 . The AI was higher in the AVN, HB and the initial tract of bundle branches than in the common myocardium (p<0.05; Student's t test).

title: Expression of apoptosis and @entity3 ( XXXX ) in the cardiac conduction system of @entity4 ( @entity4 ).

answer: @entity3


abstract: Synergistic @entity1 catabolite repression of the @entity4 aconitase (citB) gene by @entity0 and a source of @entity6 is dependent on DNA sequences located upstream of the gene. Mutations in a dyad symmetry element centered at position -66 and in a repeat of the downstream arm of the dyad symmetry at position -27 cause derepressed citB expression. In this work, a protein able to bind to a DNA fragment containing these elements was purified and identified. This protein, named CcpC (Catabolite control protein C), shares sequence similarity with members of the LysR family of transcriptional regulators. In addition to binding to the citB promoter, CcpC bound to the promoter of the citZ gene, which encodes the cell' @entity5 @entity3 synthase and is subject to @entity1 catabolite repression. In a ccpC null mutant, expression of both citB and citZ was derepressed in @entity0 - @entity2 minimal medium, indicating that CcpC is a negative regulator of citB and citZ gene expression. DNase I footprinting experiments showed that CcpC binds to two sites within the citB promoter region, corresponding to the dyad symmetry and -27 elements. In the presence of @entity3 , a putative inducer, only the dyad symmetry element was fully protected by CcpC. When the dyad symmetry element was mutated, CcpC was no longer able to bind to either the dyad symmetry or -27 elements. Repression of citB and citZ gene expression during anaerobiosis also proved to be mediated by CcpC.

title: CcpC, a novel regulator of the LysR family required for XXXX repression of the citB gene in @entity4 .

answer: @entity0


abstract: Purpose To assess the ability of noninvasive vascular elastography (NIVE) to help characterize @entity4 and @entity2 organization in a @entity0 model of @entity3 after @entity1 repair with stent-grafts, in comparison with computed tomography (CT) and pathologic examination findings. Materials and Methods All protocols were approved by the Animal Care Committee in accordance with the guidelines of the Canadian Council of Animal Care. Stent-grafts were implanted in a group of 18 @entity0 with @entity1 created in the abdominal aorta. @entity4 was created in four @entity1 ; @entity4 , in 13 @entity1 ; and no @entity4 , in one @entity1 . Doppler ultrasonography and NIVE examinations were performed at baseline and at 1-week, 1-month, 3-month, and 6-month follow-up. Angiography, CT, and macroscopic tissue examination were performed at sacrifice. Strain values were computed by using the Lagrangian speckle model estimator. @entity4 , solid organized @entity2 , and fresh @entity2 were identified and segmented by comparing the results of CT and macroscopic tissue examination. Strain values were compared by using the Wilcoxon rank-sum and Kruskal-Wallis tests. Results All stent-grafts were successfully deployed, and @entity4 were clearly depicted in the last follow-up elastography examinations. Maximal axial strains over consecutive heart cycles in @entity4 , organized @entity2 , and fresh @entity2 areas were 0.78%    0.22, 0.23%    0.02, 0.10%    0.04, respectively. Strain values were significantly different between @entity4 and organized or fresh @entity2 areas (P < .000) and between organized and fresh @entity2 areas (P < .0002). No correlation was found between strain values and type of @entity4 , sac pressure, @entity4 size, and @entity1 size. Conclusion NIVE may be able to help characterize @entity4 and @entity2 organization, regardless of the size, pressure, and type of @entity4 . (  ) RSNA, 2015.

title: Endovascular Repair of XXXX : Follow-up with Noninvasive Vascular Elastography in a @entity0 Model.

answer: @entity3


abstract: OBJECTIVE: Prognostic factors in @entity0 who underwent pulmonary angioplasty remain controversial. Here, we report a case-series study of this surgical procedure based on our 20-year single-center experience. METHODS: Medical records of @entity0 , who underwent a major @entity1 operation with pulmonary artery resection, were reviewed retrospectively. RESULTS: From 1986 to 2006, 61 (3%) of 2296 @entity0 required pulmonary artery resection to avoid pneumonectomy for @entity1 surgery. We performed 34 circumferential resections and 27 wedge resections accompanied by lobectomy or bilobectomy, and all repairs were performed with end-to-end anastomoses or direct suturing. Patch reconstruction, synthetic/biological prosthesis, and pericardial conduit were not used. Forty-nine @entity0 (80%) underwent concomitant carinoplasty (n = 2) or bronchoplasty (n = 47). After surgery, two @entity0 died (mortality 3.3%) and major complications were noted in 14 @entity0 (morbidity 23.0%). Although seven @entity0 had local recurrences (four intrathoracic and three lymph nodes), no recurrence was observed along the pulmonary artery suture line. With a mean follow-up period of 46.0    40.5 months, overall and disease-free survival rates for all cases were 47.0% and 40.0% at 5 years, and 40.2% and 33.6% at 10 years. According to the nodal status, the 5-years' overall and disease-free survivals were 76.0% and 62.9% for pN0 cases (n = 14), 45.7% and 43.5% for @entity3 cases (n = 27), and 28.9% and 20.0% for @entity2 + @entity4 cases (n = 20), respectively (p = 0.014 and 0.036). Multivariate analysis indicated that nodal status was the only prognostic factor on both overall and disease-free survival. CONCLUSIONS: A major anatomical lung operation with pulmonary artery resection is feasible for selected @entity0 with primary @entity1 . Long-term outcomes are significantly influenced by nodal status and are comparable to those of conventional lobectomy. Most operative complications are controllable with acceptable mortality and morbidity rates. The anastomosed site was not placed at risk for local recurrence. These data support pulmonary angioplasty as a valuable option in the treatment of @entity1 .

title: Factors affecting survival after lobectomy with pulmonary artery resection for primary XXXX .

answer: @entity1


abstract: The Ottawa Knee Rule (OKR) is a clinical decision rule for the ordering of knee radiographs by physicians in @entity0 with blunt @entity2 . However, in many Emergency Departments, radiographs are also ordered by nurses during triage. This study was designed to compare application of the OKR by triage nurses and physicians. A consecutive sample of all @entity0 presenting to the Emergency Department (ED) of a tertiary care military teaching hospital with blunt @entity2 that met OKR inclusion criteria were enrolled. Radiographs were ordered on all @entity0 . Nurses and physicians were blinded to each other's examinations. Nurse-physician inter-reviewer reliability was compared using the kappa statistic. Of 172 enrolled subjects, 38 were excluded for incomplete data or multiple entries, leaving 134 study @entity0 . Four @entity1 (3%) were detected. Fair inter-observer reliability was found on four of the five OKR components: patellar tenderness (PT, kappa = 0.31), proximal fibula tenderness (PFT, kappa = 0.31), inability to flex > 90 degrees (FLEX, kappa = 0.24) and inability to walk four steps (WALK, kappa = 0.44). Nurses were more likely to overestimate the presence of individual components (PT 3.5x, @entity3 6.6x, FLEX 1.9x and WALK 4.8x) and were 3.6 times more likely than Emergency Physicians (EP), overall, to order radiographs, representing a 21% vs. 37% reduced radiography rate, respectively. No @entity1 were missed by physicians or nurses. Triage nurses and EPs in this study had fair agreement in their application of the OKR. Triage nurses greatly overestimated @entity2 , while maintaining sensitivity, at the expense of specificity and cost savings.

title: Ottawa Knee Rule: a comparison of physician and triage-nurse utilization of a decision rule for XXXX radiography.

answer: @entity2


abstract: BACKGROUND: Disease surveillance in @entity0 with @entity3 is important for early diagnosis of progression and @entity1 and for optimised treatment. OBJECTIVE: To develop urine and plasma assays for disease surveillance for @entity0 with @entity4 and @entity5 @entity2 mutations. DESIGN, SETTING, AND @entity0 : Droplet digital polymerase chain reaction (ddPCR) assays were developed and @entity2 DNA from two @entity0 cohorts was screened for @entity4 and @entity5 hotspot mutations. One cohort included 363 @entity0 with non-muscle-invasive @entity3 (NMIBC). The other cohort included 468 @entity0 with @entity3 undergoing radical cystectomy (Cx). Urine supernatants (NMIBC n=216, Cx n=27) and plasma samples (NMIBC n=39, Cx n=27) from @entity0 harbouring mutations were subsequently screened using ddPCR assays. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Progression-free survival, recurrence-free survival, and overall survival were measured. @entity6 's exact test, the Wilcoxon rank-sum test and Cox regression analysis were applied. RESULTS AND LIMITATIONS: In total, 36% of the NMIBC @entity0 (129/363) and 11% of the Cx @entity0 (44/403) harboured at least one @entity4 or @entity5 mutation. Screening of DNA from serial urine supernatants from the NMIBC cohort revealed that high levels of @entity2 DNA (tDNA) were associated with later disease progression in NMIBC (p=0.003). Furthermore, high levels of tDNA in plasma samples were associated with recurrence in the Cx cohort (p=0.016). A positive correlation between tDNA levels in urine and plasma was observed (correlation coefficient 0.6). The retrospective study design and low volumes of plasma available for analysis were limitations of the study. CONCLUSIONS: Increased levels of @entity4 and @entity5 mutated DNA in urine and plasma are indicative of later progression and @entity1 in @entity3 . @entity0 SUMMARY: Urine and plasma from @entity0 with @entity3 may be monitored for diagnosis of progression and @entity1 using mutation assays.

title: Liquid Biopsy Analysis of @entity4 and @entity5 Hotspot Mutations for Disease Surveillance in XXXX .

answer: @entity3


abstract: It is the position of the American Dietetic Association (ADA) that access to adequate amounts of safe, nutritious, and culturally appropriate food at all times is a fundamental @entity0 right. Hunger continues to be a worldwide problem of staggering proportions. The Association supports programs and encourages practices that combat hunger and @entity1 , produce food security, promote self-sufficiency, and are environmentally and economically sustainable. The Association is aware that hunger exists in a world of plenty and that poverty, gender inequity, ethnocentrism, racism, and the lack of political will are key constraints to solving the problems of global hunger and @entity1 . Recognizing that simplistic approaches are inadequate, the ADA identifies sustainable development as the long-term strategy to ending world hunger and achieving food security. Sustainable development requires political, economic, and social changes that include empowering the disenfranchised, widening access to assets and other resources, narrowing the gap between rich and poor, and adjusting consumption patterns so as to foster good stewardship of nature. Additionally, because the health status of future generations is related to the well-being of their mothers, achieving food security will also require increased access for @entity0 to education, adequate health care and sanitation, and economic opportunities. This position paper reviews the complex issues of global food insecurity and discusses long-term solutions for achieving world food security. Achieving the end of world hunger has been and is now within our grasp. There is sufficient food to feed everyone, and solutions can be realized now that will benefit all of humanity. As noted in the paper, most @entity0 who examine the costs of ending versus not ending world hunger are bewildered by the question of why humanity did not solve the problem a long time ago. The Association supports programs and encourages practices that combat hunger and @entity1 , produce food security, promote self-sufficiency, respect local cultures, and are environmentally and economically sustainable. The ADA recognizes that decisions and actions that dietetics professionals make as practitioners and consumers can help reduce the extent of poverty and hunger both here and abroad. This paper provides information, resources, and strategies to assist dietetics professionals in improving the public's understanding of key issues, becoming advocates of the poor, and influencing the political will to end world hunger.

title: Position of the American Dietetic Association: Addressing world hunger, XXXX , and food insecurity.

answer: @entity1


abstract: UNASSIGNED: Background @entity1 are usually seen as minute low-density lesions and this may be attributed to relatively low sensitivity on visual assessment using computed tomography (CT). @entity1 can be detected by using the accurate region of interest (ROI) setting, while small ROI settings by less-experienced radiologists may result in false negative findings. Purpose To evaluate the diagnostic ability of our proposed method (" @entity2 -weighted" imaging [OWI]), which is based on reversing the density, compared with conventional CT (CCT) imaging alone. Material and Methods Temporal bone CTs of consecutive @entity0 with @entity2 were analyzed. Gender- and age-matched control @entity0 were also included. All CT images were obtained using a 64-detector row scanner. OWI was obtained by extracting the temporal bone region using the threshold technique and reversing the density (black to white). Four independent radiologists took part in two reading sessions. In the first session, the observers read only CCT imaging. In the second session, they read OWI along with the CCT imaging. Sensitivity was assessed for the four readers. Results Thirty temporal bones of 25 @entity0 with @entity2 (3 @entity0 , 22 @entity0 ; mean age, 53.9        9.0 years) and 30 temporal bones of 30 control @entity0 (4 @entity0 , 26 @entity0 ; mean age, 44.0        16.2 years) were included. For all observers, reading with a combination of the two methods was associated with a higher sensitivity (63.3-80.0%) than with conventional CT images alone (30.0-60.0%; P   <   0.05, each). Conclusion Application of our proposed method based on threshold value may help detect foci of @entity2 .

title: Additive value of " XXXX -weighted" images for the CT diagnosis of @entity2 .

answer: @entity2


abstract: @entity4 is the most frequent complication of surgical treatment. The occurrence of @entity2 depends on many factors, but the most important is bacterial contamination of wound according to the site of operation. The aim of this study was to establish wound @entity2 rate and to determine the relationship between site of operation, wound contamination and the other surgery related factors and @entity4 risk. The material was 1527 surgically treated @entity0 in the 3rd Surgical Department of the Collegium Medicum of the Jagiellonian University during one year. From the study population were excluded 66 @entity0 with wounds of the head and 7 @entity0 who died within three days after surgery without wound @entity2 signs. The healing of each wound was observed during the @entity0 's hospitalisation and 30 days after discharge from hospital, and in orthopedic @entity0 6 months after discharge. The total number of 132 infected wounds was identified. The population of 1352 wounds healed without any complications was a control group. Data were recorded in a Wound Infection Register Card and were collected in the computer database. The data were statistically analysed. Relations between single factor and @entity4 were evaluated using chi2 statistics and in the small group Fisher's exact probability test. Odds ratios and corresponding 95% confidence intervals were computed for all variables. The overall wound @entity2 rate was 8.9%. The significant factors (p < 0.05) were @entity3 , reoperation, intraoperative X-ray examination, haematoma of the wound after operation, skeletal traction prior to surgery and implantation of prosthetic material in clean wounds. CONCLUSIONS: 1. Wound contamination, site of operation (GI tract), open drainage, reoperation, intraoperative X-ray examination and postoperative haematoma of the wound are statistically significant risk factors which influence @entity4 rate. 2. @entity1 of wound is the most important local risk factor of wound @entity2 after surgery.

title: [ XXXX . II. Risk factors related to surgery].

answer: @entity4


abstract: OBJECTIVES: We investigated homecare @entity0 with @entity2 ( @entity2 ; n = 36) or @entity4 ( @entity4 ; n = 36) and their care-providing relatives regarding clinical and psychosocial variables to determine whether @entity2 and @entity4 impose different burdens on caregivers. METHOD: All @entity0 were diagnosed according to ICD-10 criteria. The diagnoses were confirmed by internal medical, clinical-neurological, and @entity1 parameters. The severity of the @entity3 was graded according to the Global Deterioration Scale (GDS). Caregiving relatives responded to the Behavioral Pathology in @entity2 Rating Scale (BAD), the Blessed @entity3 Scale (BDS), and the Screen for Caregiver Burden (SCB). RESULTS: Analyses revealed that caregivers' burden (SCB), disease symptoms and personality changes of @entity0 (BAD), and the @entity0 ' inability to cope with everyday tasks (BDS) were sharply higher for @entity2 than for @entity4 @entity0 in the group with severe @entity3 . Concerning @entity0 with mild or moderately severe disease, scores in the @entity2 group were similar or lower than those in the @entity4 group. CONCLUSION: In early stages, @entity4 @entity0 impose a greater burden on relatives than do @entity0 with @entity2 . In severe stages this relationship undergoes a reversal, with relatives of @entity2 @entity0 experiencing the burden more adversely than those of @entity4 @entity0 . The differences in the onset and course characteristics, as well as the specific differences between these two types of @entity3 with respect to caregiver burden factors, call for their diagnostic separation and the development of specific homecare support systems for family caregivers.

title: XXXX versus @entity2 : do they have differential effects on caregivers' burden?

answer: @entity4


abstract: BACKGROUND: Partial tetrasomy is mainly described as a cytogenetically visible rearrangement due to a supernumerary chromosome (i(12p), i(18p), @entity6 dup(15)). Except for chromosome 15q11q13, intrachromosomal triplications are rare and so far not associated with a recognisable phenotype. METHODS AND RESULTS: This report describes two unrelated @entity0 with a de novo non-recurrent submicroscopic interstitial triplication 11q24.1 detected with array comparative genomic hybridisation and confirmed by fluorescence in situ hybridisation, molecular combing, and quantitative PCR. Microsatellite analysis suggested that a common mechanism of rearrangement might have been involved. These @entity0 share remarkably similar clinical features including distinctive @entity2 , @entity4 with small extremities, @entity5 , overweight, and @entity3 . The overlapping region of 1.8 Mb contains 11 RefSeq genes and three microRNA related genes. Interestingly, the overexpression of @entity7 , a gene encoding an adipocyte specific adhesion molecule, may contribute to @entity0 ' @entity1 . Upregulation of BILD, known to mediate apoptosis in a caspase dependent manner, could deserve further investigation into the pathological mechanism of @entity5 . CONCLUSION: Isolated duplications of distal 11q region have been previously reported and associated with @entity3 but without a consistent set of clinical features. These findings support the proposal that microtriplication 11q24.1 is a well recognisable clinical entity.

title: Microtriplication of 11q24.1: a highly recognisable phenotype with @entity4 , distinctive facial features, XXXX , overweight, and @entity3 .

answer: @entity5


abstract: In @entity4 , endothelial cell selectins can promote @entity1 cell attachment via interactions with sialylated Lewis antigens present at the surface of @entity1 cells, thereby facilitating @entity1 cell arrest and transmigration into the extravascular space. However, it is not known whether Lewis antigens interact with @entity4 cells and modify their migration. Our aim was to detect the presence of binding sites on @entity0 @entity1 cells for Lewis(a/x) antigens and their sialylated derivatives in vitro and in vivo and to analyze their influence on migration of @entity4 cells. The immunocytochemical and histochemical levels of expression of the four Lewis antigens were quantitatively determined in four @entity0 @entity4 cell lines and in in vivo @entity2 xenografts. The levels of expression of specific binding sites for these sugar epitopes were determined by synthetic neoglycoconjugates. The influence of binding of these @entity5 ligands on @entity1 cell migration was quantitatively evaluated by computer-assisted phase-contrast videomicroscopy performed on Matrigel culture supports either left uncoated or coated with neoglycoconjugate presenting synthetic Lewis(a), sialyl Lewis(a), Lewis(x), or sialyl Lewis(x) antigens. The influence of the @entity3 concentration in the culture medium on the Lewis antigen-mediated effects was checked. @entity0 @entity4 cells expressed significant amounts of specific binding sites detected by the synthetic probes in addition to the oligosaccharide epitopes. The expression levels differed considerably between the four cell lines and between in vitro and in vivo specimens. Cell migration analysis revealed that the four Lewis antigens markedly decreased the levels of migration of the HCT-15 and LoVo @entity1 cells. This effect depends on the @entity3 concentration in the culture medium. Binding sites for @entity6 are present on @entity4 cells. The functional relevance of these sites is indicated by the negative influence on cell migration of a matrix containing the oligosaccharides as ligand parts.

title: Binding sites for Lewis antigens are expressed by @entity0 XXXX cells and negatively affect their migration.

answer: @entity4


abstract: STUDY OBJECTIVE: To report the feasibility of performing robotic single-port surgery including pelvic lymphadenectomy in @entity2 . DESIGN: Canadian Task Force III SETTING: A 49 year-old, multiparous @entity0 diagnosed with well differentiated, FIGO stage I, @entity4 . The @entity0 underwent a robotic single-port peritoneal washing, total hysterectomy, bilateral adnexectomy and pelvic lymphadenectomy. The procedure was performed using the da Vinci Si Surgical System (Intuitive Surgical, Sunnyvale, CA) through a single 2.5cm umbilical incision. We used the 5 lumen port for single site instruments, 3-dimensional @entity3 8.5mm endoscope, 5mm accessory port and insufflation channel. Monopolar cautery and bipolar Maryland dissector were used for lymphadenectomy. Vaginal cuff closure was performed using needle driver and Maryland dissector with V-lock suture. Near the end of the surgery, 5mm assistant port was changed with 10mm-sized port. Then dissected lymph node in endobag and a needle used in vaginal cuff closure were removed through 10mm port. INTERVENTION: Total hysterectomy, bilateral adnexectomy with both pelvic lymphadenectomy were performed using robotic single-site platform. MEASUREMENTS AND MAIN RESULTS: Total operative time was 206 minutes. Total vaginal cuff closure time was 22 minutes and both lymphadenectomy have taken 48 minutes. Estimated @entity1 was 100 ml, no intra-operative and post-operative complications occurred. Total number of excised lymph-node was 11. CONCLUSION: Robotic single-port pelvic lymphadenectomy is feasible. Further studies should be performed to assess the benefits of this procedure.

title: Robotic Single-Port hysterectomy, adnexectomy and lymphadenectomy in XXXX .

answer: @entity2


abstract: UNASSIGNED: OBJECTIVE @entity8 ( @entity8 ) may cause @entity6 due to @entity2 ( @entity2 ). @entity1 has been identified in select @entity0 , leading to stenting as a potential treatment, but its effects on global @entity2 have not been completely defined. The purpose of this pilot study was to assess the effects of @entity1 stenting on @entity2 in a small group of @entity0 with @entity8 . METHODS Ten @entity0 for whom medical therapy had failed were prospectively followed. Ophthalmological examinations were assessed, and @entity0 with @entity1 on MR angiography proceeded to catheter angiography, venography with assessment of pressure gradient, and @entity2 monitoring. @entity0 with @entity2 measurements and an elevated pressure gradient across the @entity4 were treated with stent placement. RESULTS All @entity0 had elevated venous pressure (mean 39.5    14.9 mm Hg), an elevated gradient across the @entity1 (30.0    13.2 mm Hg), and @entity2 (42.2    15.9 mm Hg). Following stent placement, all @entity0 had resolution of the @entity4 and gradient (1    1 mm Hg). The @entity2 values showed an immediate decrease (to a mean of 17.0    8.3 mm Hg), and further decreased overnight (to a mean of 8    4.2 mm Hg). All @entity0 had subjective and objective improvement, and all but one improved during follow-up (median 23.4 months; range 15.7-31.6 months). Two @entity0 developed stent-adjacent @entity4 ; retreatment abolished the @entity4 and gradient in both cases. @entity0 presenting with @entity5 had resolution on follow-up funduscopic imaging and optical coherence tomography (OCT) and improvement on visual field testing. @entity0 presenting with @entity7 had optic nerve thinning on follow-up OCT, but improved visual fields. CONCLUSIONS For selected @entity0 with @entity8 and @entity1 with an elevated pressure gradient and @entity2 , @entity1 stenting results in resolution of the venous pressure gradient, @entity3 , and functional, neurological, and ophthalmological improvement. As @entity0 are at risk for stent-adjacent @entity4 , further follow-up is necessary to determine long-term outcomes and gain an understanding of @entity1 as a primary or secondary pathological process behind @entity2 .

title: @entity1 stenting for reduction of XXXX in @entity8 : a prospective pilot study.

answer: @entity2


abstract: INTRODUCTION: @entity4 (NO) modulates inflammatory reactions, having beneficial or toxic effects depending on the concentration. Its elevation can cause proinflammatory effects amplifying the inflammatory process with the participation of cytokines. Smoking has a negative impact on health and is considered one of the risk factors that influence disease development facilitating inflammatory processes. AIM: To compare the serum concentration of NO and cytokines in smokers at baseline and after 4months of abstinence treatment. METHODS: Blood samples which were collected to obtain the serum, at baseline and after 4months, were stored at -80  C until analysis. NO was measured by the total dose of @entity7 determined by the Greiss method. CBA was the used technique to determine the concentration of cytokines in supernatants serum. The initial and final results of NO, @entity0 , @entity5 , @entity1 , @entity2 , @entity3 and IL-12 that remained after 4months treatment were compared. Wilcoxon test was used to compare the data and Spearman test for correlations between NO and other variables. A significance level of p<0.05 was adopted. RESULTS: The analysis of NO observed a significant reduction (p=0.001) of the initial median value of 18.80 (3.55-80.01)  mol/L to 8.10 (2.85-14.97)  mol/L after 4months of treatment. There were no significant differences in cytokines from baseline to the end of treatment. CONCLUSION: The results may not mean harm to the body, but an adaptive process, decreasing the metabolism of abstinents due to the reduction of the use of @entity6 .

title: Serum levels of XXXX and cytokines in smokers at the beginning and after 4months of treatment for smoking cessation.

answer: @entity4


abstract: PURPOSE: @entity9 has been found to be dramatically reduced in a genetic @entity0 @entity5 model following exposure to sublethal, head-only irradiation. In this study, the same radiation treatment was used prior to experimental induction of @entity7 (IOP) to determine if radiation is neuroprotective in another @entity5 model. METHODS: Episcleral vein injection of hypertonic saline was used to elevate IOP unilaterally in two groups of @entity1 : (1) otherwise untreated and (2) radiation pretreated, n > 25/group. Intraocular pressure histories were collected for 5 weeks, when @entity6 were prepared and graded for injury. Statistical analyses were used to compare IOP history and @entity3 . The density of microglia and macrophages in two nerve head regions was determined by @entity8 immunolabeling. RESULTS: Mean and peak IOP elevations were not different between the two @entity5 model groups. Mean @entity9 grades were not different in @entity5 model @entity6 and were equivalent to approximately 35% of axons degenerating. Nerves selected for lower mean or peak IOP elevations did not differ in @entity9 . Similarly, nerves selected for lower injury grade did not differ in IOP exposure. By multiple regression modeling, @entity3 grade was most significantly associated with mean IOP (P < 0.002). There was no significant effect of radiation treatment. @entity8 + cell density was not altered by radiation treatment. CONCLUSIONS: In contrast to previous observations in a @entity0 @entity2 model, head-only irradiation offers the adult @entity1 optic nerve no protection from @entity4 due to chronic, experimentally induced IOP elevation.

title: Radiation pretreatment does not protect the XXXX optic nerve from @entity7 -induced injury.

answer: @entity1


abstract: OBJECTIVE: To compare lumbar paraspinal, gluteus maximus, and biceps femoris muscle function during sagittal trunk flexion and extension in @entity0 with @entity3 and healthy control subjects, and to assess the influence of rehabilitation in the @entity2 @entity0 . DESIGN: A cross-sectional study comparing @entity3 @entity0 and healthy controls, and a prospective follow-up in @entity2 @entity0 during rehabilitation. SETTING: Physical medicine and rehabilitation clinic. SUBJECTS: Nineteen @entity0 with @entity3 , and 19 @entity0 without @entity1 (controls). INTERVENTION: Five-week active outpatient rehabilitation (1 hour three times a week) guided by a physiotherapist, followed by 5-week self-motivated exercise at home. OUTCOME MEASURES: Subjects performed sagittal trunk flexion and extension while surface electromyogram was bilaterally recorded of paraspinal (L1-L2 level), gluteus maximus, and biceps femoris muscles. The muscle activity was assessed from the average electromyogram and the relative muscle activation onsets and their duration were calculated. RESULTS: During early flexion, lumbar paraspinal and biceps femoris were activated simultaneously before gluteus maximus. At the end of flexion and during extension all investigated muscles were activated and relaxed in order. Lumbar paraspinal and biceps femoris muscles were activated in a similar order in @entity3 @entity0 and healthy controls during flexion and extension. However, the duration of gluteus maximus activity was shorter in the @entity2 @entity0 than in controls during the trunk flexion (p<.05), and it ended earlier during extension. Active rehabilitation did not change the muscle activities of lumbar paraspinal and biceps femoris in the @entity2 @entity0 , but in the measurements after rehabilitation the onset of gluteus maximus activity occurred later in flexion and earlier in extension. CONCLUSIONS: The activity of the gluteus maximus muscle during the flexion-extension cycle was reduced in @entity0 with @entity3 . The gluteal muscles should be taken into consideration in the rehabilitation of these @entity0 .

title: Back and hip extensor activities during trunk flexion/extension: effects of XXXX and rehabilitation.

answer: @entity3


abstract: BACKGROUND: Intraoperative magnetic resonance imaging (MRI) for guided biopsy or microsurgical resection of @entity2 is gaining broader acceptance. It is not known whether intraoperative MRI has the potential to detect @entity0 of these surgical procedures, because scientific research has so far focussed on the signal characteristics of less acute clots. It is the objective of this experimental study to investigate whether MRI can visualise intracerebral blood within minutes after its occurrence. METHODS: In 26 @entity3 , a frontal @entity1 was produced by injecting autologous blood. Twenty @entity3 underwent MRI 30 minutes after injection, and 6 @entity3 within the first 10 minutes. MRI scans were performed on a 1.5T system. T1-weighted @entity4 ( @entity4 ), T2-weighted @entity4 ( @entity4 ), T2-weighted fluid attenuated inversion recovery (FLAIR), and T2-weighted gradient echo (GE) images were acquired. Depending on the differences of the signal intensities of the @entity1 and the surrounding brain, the detectability of the @entity1 was rated as good, fair, or poor. RESULTS: None of the induced @entity1 were rated to be clearly visible on T1-weighted sequences. Six of the 26 @entity1 (23%) were easily detectable on FLAIR sequences, 18 @entity1 (69%) on T2-weighted @entity4 sequences, and 23 @entity1 (88%) on the T2-weighted GE sequences. CONCLUSION: Extravasated blood can be identified with a high reliability within minutes after its occurrence on MRI provided that T2-weighted GE sequences are used for imaging. In conclusion, intraoperative MRI is not only of value for guidance of neurosurgical procedures, but also for immediate detection of @entity0 .

title: The role of intraoperative magnetic resonance imaging for the detection of XXXX during surgery for intracerebral lesions an experimental approach.

answer: @entity0


abstract: UNASSIGNED: A novel commercial training mask purportedly allows for combined respiratory muscle training and altitude exposure during exercise. We examined the mask's ability to deliver on this claim. Ten males completed three bouts of treadmill exercise at a matched workload(60%VO2peak) in a controlled laboratory environment. During exercise the mask was worn in two manufacturer-defined settings [9000ft(9k) and 15,000ft(15k)] and a Sham configuration(   3500ft). Ventilation(VE), tidal volume(VT), respiratory rate(RR), expired @entity0 (FEO2) and @entity2 (FECO2), peripheral @entity0 saturation(SPO2), heart rate(HR), and RPE were measured each minute during exercise and subjects completed the Beck Anxiety Inventory(BAI) immediately following. The mask caused a reduction in VE of    20L/min in both the 9k and 15k configurations(p<0.001). This was due to a reduction in RR of    10 bpm, but not VT, which was elevated by    250ml(p<0.001). FEO2 was reduced and FECO2 was elevated above Sham in both 9k and 15k(p<0.001). @entity3 was not different across conditions(p=0.210) butVCO2 trended lower at 9k(p=0.093) and was reduced at 15k(p=0.016). VE/VO2 was 18.3% lower than Sham at 9k and 19.2% lower at 15k. VE/VCO2 was 16.2% lower than Sham at 9k and 18.8% lower at 15k(all p<0.001). HR increased with exercise(p<0.001) but was not different between conditions(p=0.285). SPO2 averaged 94% in Sham, 91% at 9k, and 89% at 15k(p<0.001). RPE and BAI were also higher in 9k and 15k(p<0.010) but there was no difference between mask conditions. The training mask caused inadequate hyperventilation that led to arterial @entity1 and psychological discomfort, but the magnitude of these responses were small and they did not vary across mask configurations.

title: 'Functional' respiratory muscle training during endurance exercise causes modest XXXX but overall is well tolerated.

answer: @entity1


abstract: Look, no ortho substituents! A series of polycycles were prepared by using a three-component Joulli  -Ugi reaction. The rate of rotation about the bond between a highly hindered bridgehead and a @entity2 ring with no ortho substituents was measured, and was highly dependent on the substitution. Rotamer half-lives of up to 21 h at 298 K were observed (see figure). Rotamers resulting from this @entity1 were isolated for the first time.A series of polycycles was prepared by using a three-component Joulli  -Ugi reaction. The rate of rotation about the bond between a highly hindered bridgehead and a @entity2 ring with no ortho substituents was measured by using, in general, variable-temperature HPLC. The rate of rotation was highly dependent on substitution and rotamer half-lives of up to 21 h at 298 K were observed. Insights into the effect of substitution on the rate of rotation were gleaned through electronic structure calculations on closely related derivatives. Rotamers resulting from @entity1 about a bond between an sp(3)-hybridised @entity0 atom and a @entity2 ring with no ortho substituents were isolated for the first time, and the equilibration of the separated rotamers was followed by using analytical HPLC. It was demonstrated, for the first time, that a highly hindered environment for the sp(3)-hybridised atom is sufficient for @entity1 about a single bond between sp(3)- and sp(2)-hybridised @entity0 atoms.

title: Remarkably XXXX about a single bond between an sp(3)-hybridised @entity0 atom and an aromatic ring without ortho substituents.

answer: @entity1