abstract: CD176 (Thomsen-Friedenreich antigen) is a @entity1 -associated @entity5 structure. In a previous study, we observed that the anti-CD176 antibody can induce the apoptosis of CD176-positive @entity6 cells. In this study, we investigated the mechanisms of apoptosis induced by the CD176 antibody. We found that @entity4 (FAS, @entity4 ) and the @entity7 ( @entity7 ) ( @entity7 ) are co-expressed with CD176 on the surface of defined @entity6 cells as observed by confocal microscopy and flow cytometry analyses. Further-more, @entity4 , @entity3 , @entity12 and @entity7 are carrier proteins of CD176 in hematopoietic cells recognized by means of sandwich solid-phase enzyme linked immunosorbent assay and co-immunoprecipitation. As shown by microarray analysis, 20 genes which are directly related to the execution, induction or positive regulation of apoptosis, were up-regulated after CD176 antibody treatment of the KG1 cell line. Nine differentially expressed genes observed in the microarray analysis were verified by quantitative real-time polymerase chain reaction in the KG1 and MT4 cell lines. Six genes ( @entity11 , @entity2 , @entity14 , @entity15 , @entity10 and @entity13 ) out of these nine are involved in five apoptotic pathways: The @entity4 signaling pathway, the @entity9 and @entity7 /5 death receptor pathway, caspase cascade in apoptosis, the mitochondrial signaling pathway, and apoptotic DNA fragmentation and tissue homeo- @entity8 . Thus, we hypothesized that the CD176 antibody binds to the CD176 @entity5 structure present on apoptosis-associated glycoproteins, such as @entity4 and @entity7 at the cellular surface, which activates apoptotic pathways, and consequently results in the apoptosis of CD176-positive cells. CD176 is expressed at the surface of @entity0 @entity6 cells, but is almost absent in normal and benign adult @entity0 tissues. Thus, CD176 could be a promising target for anti- @entity1 therapy based on the induction of @entity1 -specific apoptosis.

title: Mechanisms of the apoptosis induced by CD176 antibody in XXXX @entity6 cells.

answer: @entity0


abstract: UNASSIGNED: Approximately 94.000 @entity1 were killed or disappeared and about 1.8 million @entity1 were forced to flee from their homes during the war in Bosnia and Herzegovina, from April 1992 to December 1995. The Dayton Peace Agreement, signed on November 21, 1995, ended the war. Life and health conditions of the population in B_H characterized with @entity2 caused by severe war and post-war traumatic events. The aim of this work is to establish the connection between @entity0 in @entity1 and stress caused by traumatic experiences during the war in B_H. We performed this study of pairs at the Clinic for Oncology, University Clinical Hospital Mostar, from November 2008 to March 2009. Two hundred @entity1 from Herzegovina region participated in this research. The study group consisted of 100 @entity1 with diagnosed @entity0 . The control group consisted of 100 @entity1 without @entity0 diagnosis, of the same age and living in the same area. We have found that @entity1 with @entity0 had statistically considerably more war traumatic experiences and thus more stress than the @entity1 in control group (p=0.000). The following conclusions are also noteworthy: 39% of @entity1 in the study group were under the ages of 50, when diagnosed @entity0 . Only one @entity1 got psychosocially care within @entity0 treatment. High middle age of physiological loss of period (>= 50), longer fertile period, as well as the smoking habit are @entity0 risk factors statistically more present. @entity1 with @entity0 have experienced more stress due to significantly more war traumatic experiences, so that war-related stress considered a risk factor.

title: The stress of war and XXXX incidence.

answer: @entity0


abstract: Differentiation of the fish-borne trematodes belonging to the Opisthorchiidae, Heterophyidae and Lecithodendriidae is important from a clinical and epidemiological perspective, yet it is impossible to do using conventional coprological techniques, as the eggs are morphologically similar. Epidemiological investigation therefore currently relies on morphological examination of adult worms following expulsion chemotherapy. A PCR test capable of amplifying a segment of the internal transcribed spacer region of ribosomal DNA for the opisthorchiid and heterophyid flukes eggs taken directly from faeces was developed and evaluated in a rural community in central Thailand. The lowest quantity of DNA that could be amplified from individual adults of Opisthorchis viverrini, @entity1 and Haplorchis taichui was estimated at 0.6 pg, 0.8 pg and 3 pg, respectively. The PCR was capable of detecting @entity0 with the aforementioned species of flukes under experimental conditions. A total of 11.6% of individuals in rural communities in Sanamchaikaet district, central Thailand, were positive for 'Opisthorchis-like' eggs in their faeces using conventional parasitological detection techniques. In comparison to microscopy, the PCR yielded a sensitivity and specificity of 71.0% and 76.7%, respectively. Analysis of the microscopy-positive PCR products revealed 64% and 23% of individuals to be infected with O. viverrini and @entity2 , respectively. The remaining 13% (three individuals) were identified as eggs of Didymozoidae, presumably being passed mechanically in the faeces following the ingestion of infected fishes. An immediate finding of this study is the identification and first report of a @entity2 -endemic community in central Thailand. This extends the known range of this @entity3 in Southeast Asia. The PCR developed herein provides an important tool for the specific identification of liver and intestinal fluke species for future epidemiological surveys.

title: A new PCR-based approach indicates the range of XXXX now extends to Central Thailand.

answer: @entity1


abstract: We report a case of @entity6 resulting from @entity12 or @entity12 . @entity12 is characterized by profuse watery @entity1 that has a low @entity7 and high @entity4 concentration. It is seen in a variety of medical and surgical conditions, but its exact cause remains unknown. It is thought to result from an imbalance of sympathetic and parasympathetic input in the distal colon. The @entity1 is secretory and driven by @entity4 secretion rather than the inhibition of @entity7 reabsorption or @entity10 secretion, which are the most common pathophysiologic mechanisms of @entity14 . Affected @entity0 often lose >100 mmol of @entity4 daily. @entity12 is associated with a dramatic upregulation of the @entity11 or BK @entity4 channel. This channel plays a prominent role in flow-mediated @entity4 secretion in the connecting tubule and collecting duct and is also upregulated in the distal colon in @entity0 with @entity3 and @entity2 . In vitro studies show that the channel is regulated by @entity13 binding to the b receptor and @entity8 upregulation, @entity9 and @entity5 , insights that can be used to help guide pharmacologic therapy. Nephrologists should be aware of @entity12 as a cause of extrarenal @entity4 loss.

title: @entity6 Associated with XXXX ( @entity12 ).

answer: @entity12


abstract: BACKGROUND: @entity6 ( @entity6 ) is a not very well known disease; it has been described principally in @entity2 and @entity1 @entity0 without significant @entity5 consumption. The @entity0 are practically asymptomatic, and the hepatic function test (HFT) shows minimal changes. The liver biopsy findings are identical to those found in @entity7 . @entity6 may progress to @entity3 . OBJECTIVE: To determine the prevalence of @entity6 in a Mexican community. METHODS: In the City of Pachuca, Mexico, we studied volunteers of both sexes who were between the ages of 17 and 75 years, all with an @entity5 consumption of < 20 g/week without any known @entity4 . A clinical review, laboratory test, and hepatic ultrasound were carried out. Subjects with HFT and ultrasound disorders were invited to continue the study with a hepatic biopsy. RESULTS: Ninety-seven volunteers completed the study, of whom 70 were non- @entity1 and 27 were @entity1 . Ten @entity0 (10.3%) had @entity6 confirmed by hepatic biopsy; the prevalence in @entity1 was 18.5% and in non- @entity1 , 7.1%. In spite of the differences between @entity6 @entity0 and the control group concerning gender, age, and @entity1 status, there was no significant statistical difference except for the gallbladder antecedent. CONCLUSIONS: The prevalence of @entity6 was 10.3% in the studied group. @entity6 is more frequent in @entity1 and @entity0 , but without a significant statistical difference. However, the odds ratio (OR) analysis shows @entity1 and female sex to be a risk factor for @entity6 ; therefore it is probable than our sample size is not large enough.

title: [Prevalence of non-alcoholic steatohepatitis. Comparative study with XXXX @entity0 ].

answer: @entity1


abstract: UNASSIGNED: In the treatment of @entity1 ( @entity1 ), interferon beta ( @entity12 ) applies. It rarely can lead to @entity9 ( @entity9 ). A 42-year-old female with @entity1 was admitted to the Department because of @entity10 , @entity7 , drowsiness and @entity6 . Four weeks earlier, she had started therapy with @entity12 -1a. Liver tests made prior to initiation of @entity12 -1a were normal but on admission to the Department exceed several times the upper limit. @entity9 was recognized and @entity12 -1a was immediately stopped. In the fourth day of hospitalization, symptoms of @entity4 have progressed. The @entity0 was transferred to the Department of Transplantation, where @entity13 developed and three days later the orthotopic liver transplantation was performed. In histopathological picture of the removed liver extensive @entity2 and @entity3 dominated. Immunosuppressive therapy consisted of @entity11 , @entity8 and tapering @entity5 . Within five years after surgery, there was no recurrence of symptoms of @entity1 and the transplanted organ is functioning properly. @entity9 is a rare complication of @entity12 therapy but it can occur. The appearance of symptoms suggestive of @entity4 should prompt extension of diagnosis and, if necessary, discontinuation of therapy.

title: @entity9 and liver transplantation in a XXXX with @entity1 treated with interferon beta.

answer: @entity0


abstract: @entity7 arising in @entity0 with @entity5 is extremely rare; to our knowledge, only three cases have been reported in the English language literature. We report a case of @entity7 in a 39-year-old @entity0 with @entity5 . Gross examination revealed that the @entity2 was a solid and irregular mass measuring 90 mm in diameter. The cut surfaces of this ill-defined @entity2 were yellow-white with @entity3 foci. Histologically, the @entity2 cells were separated into lobules by branching, fibrous septa containing lymphocytes. In some parts of the @entity2 , a cord-like arrangement of @entity2 cells was present. Immunohistochemically, the @entity2 cells were strongly and diffusely positive for antiplacental alkaline phosphatase antibody along their cytoplasmic membranes, but negative for both chorionic gonadotrophin and @entity4 . Based on these findings, we diagnosed this @entity2 as a @entity7 . The testes when examined were found to be @entity6 bilaterally, but with no @entity2 lesions. Chromosomal analysis yielded a 47XXY karyotype, compatible with @entity5 . These findings indicate a case of primary @entity7 in @entity5 . The @entity0 underwent intensive radiation therapy postoperatively, and he demonstrated no evidence of recurrence or @entity1 during the 13-month period following surgery.

title: @entity7 in XXXX .

answer: @entity5


abstract: Some @entity2 @entity0 suffering acute @entity7 develop massive @entity9 and @entity10 , a condition known as @entity7 . Severe swelling @entity4 ( @entity4 ) and leads to progressive @entity3 . Once @entity4 reaches critical values (>30 mm Hg) @entity10 occurs, usually within 2 to 5 days. @entity0 rarely survive (80% mortality) with standard treatment, and those who do are often severely disabled. @entity7 is often missed by neurologists, despite well-defined clinical and neuroimaging (CT scan) diagnostic criteria. After diagnosis, conventional treatments such as osmotherapy, barbiturates, buffers, and hyperventilation center on reducing @entity4 . The goal of hyperosmolar therapy is to increase the serum osmolarity to approximately 315-320 mOsm/L. Enteric @entity5 is used routinely to reduce @entity4 . In more severe cases and when @entity5 fails, @entity8 may be administered. Other therapies are also available, including hypertonic saline solution, THAM ( @entity11 ) buffer, and high-dose barbiturates. Hyperventilation also helps reduce @entity4 . All measures work effectively for a short time only. Other approaches to control @entity4 , including decompression surgery and @entity6 , have shown promising results. In the Heidelberg decompression surgery trial, mortality in surgically treated @entity0 was significantly lower (32%) than in non-treated @entity0 (76%) despite conventional treatment. Importantly, of the surviving treated @entity0 , 66% were rated independent with only mild to moderate disability. Moderate @entity6 (33-36 degrees C) has recently been shown to be effective in severe @entity7 . @entity6 induction within 14 hours of @entity1 and maintained for 72 hours significantly reduced @entity4 and mortality (44%).

title: Treatment options for large hemispheric XXXX .

answer: @entity2


abstract: Understanding @entity0 clonality is critical to understanding the mechanisms involved in tumorigenesis and disease progression. In addition, understanding the clonal composition changes that occur within a @entity0 in response to certain micro-environment or treatments may lead to the design of more sophisticated and effective approaches to eradicate @entity0 cells. However, tracking @entity0 clonal sub-populations has been challenging due to the lack of distinguishable markers. To address this problem, a VDJ-seq protocol was created to trace the @entity3 patterns of @entity2 ( @entity2 ) relapse by exploiting VDJ recombination and somatic hypermutation (SHM), two unique features of B cell lymphomas. In this protocol, Next-Generation sequencing (NGS) libraries with indexing potential were constructed from amplified rearranged @entity4 ( @entity4 ) VDJ region from pairs of primary diagnosis and relapse @entity2 samples. On average more than half million VDJ sequences per sample were obtained after sequencing, which contain both VDJ rearrangement and SHM information. In addition, customized bioinformatics pipelines were developed to fully utilize sequence information for the characterization of @entity4 -VDJ repertoire within these samples. Furthermore, the pipeline allows the reconstruction and comparison of the clonal architecture of individual @entity0 , which enables the examination of the clonal heterogeneity within the diagnosis @entity0 and deduction of @entity3 patterns between diagnosis and @entity0 pairs. When applying this analysis to several diagnosis-relapse pairs, we uncovered key evidence that multiple distinctive @entity0 evolutionary patterns could lead to @entity2 relapse. Additionally, this approach can be expanded into other clinical aspects, such as identification of minimal @entity1 , monitoring relapse progress and treatment response, and investigation of immune repertoires in non-lymphoma contexts.

title: VDJ-Seq: Deep Sequencing Analysis of Rearranged @entity4 Gene to Reveal XXXX .

answer: @entity2


abstract: The expression and distribution of @entity4 , @entity3 and @entity6 receptors was examined by immunohistochemical staining in 31 @entity5 -embedded sections from @entity1 and the results were assessed by semiquantitative image analysis. Immunohistochemical staining showed heterogeneous patterns of @entity2 receptor distribution, with mainly nuclear immunoreactivity. Eighty-four percent of benign and @entity1 expressed @entity4 receptors (AR), 74.19% @entity3 receptors (ER) and 41.16% @entity6 receptors (PR). All @entity0 showed immunoreactivity for the three @entity2 receptors. @entity0 expressed higher AR and ER histochemical scores (H-scores) than PR (82% vs 71% vs 39%). The incidence and expression levels of the @entity2 receptors varied widely in the different histological types of @entity0 . Spearman rank analysis showed a positive significant (P < 0.05) correlation between AR- and ER and between ER- and PR-H-scores. In @entity1 , neither AR, ER nor PR immunohistochemical scores correlated with @entity0 FIGO stage. Densitrometric analysis of immunostained @entity2 receptors is a valid method for assessing the @entity2 status, because it reduces subjective elements in scoring sections and increases the reliability of results. The high incidence of AR expression confirms the functional role of AR in @entity1 and suggests that the determination of AR content in @entity1 could have prognostic value.

title: @entity4 receptors in XXXX : correlation with oestrogen and @entity6 receptors in an immunohistochemical and semiquantitative image analysis study.

answer: @entity1


abstract: The authors have previously described a model of in vivo tissue generation based on an implanted, microsurgically created vessel loop in a plastic chamber (volume, 0.45 ml) containing a @entity1 ( @entity1 ) scaffold. Tissue grew spontaneously in association with an intense angiogenic sprouting from the loop and almost filled the chamber, resulting in a mean amount of tissue in chambers of 0.23 g with no added matrix scaffold and 0.33 g of tissue in @entity1 -filled chambers after 4 weeks of incubation. The aim of the present study was to investigate whether a greater volume of tissue could be generated when the same-size vessel loop was inserted into a larger (1.9 ml) chamber. In four groups of five @entity0 , an arteriovenous shunt sandwiched between two disks of @entity1 , used as a scaffold for structural support, was placed inside a large polycarbonate growth chamber. Tissue and @entity1 weight and volume, as well as histological characteristics of the newly formed tissue, were assessed at 2, 4, 6, and 8 weeks. Tissue weight and volume showed a strong linear correlation. Tissue weight increased progressively from 0.13 +/- 0.04 g at 2 weeks to 0.57 +/- 0.06 g at 6 weeks (p < 0.0005). @entity1 weight decreased progressively from 0.89 +/- 0.07 g at 2 weeks to 0.20 +/- 0.09 g at 8 weeks (p < 0.0005). Histological examination of the specimens confirmed increased tissue growth and maturation over time. It is concluded that larger quantities of tissue can be grown over a longer period of time by using larger-size growth chambers.

title: Increasing the volume of vascularized tissue formation in engineered constructs: an experimental study in XXXX .

answer: @entity0


abstract: @entity4 is a rare and @entity5 . Pathogenic driver mutations are largely unknown. We present the case of a @entity0 with recurrent @entity4 , who initially showed good response to @entity9 , followed by progression. Using comprehensive molecular techniques, we explored the potential mechanisms of resistance. By low-read-depth whole-genome sequencing, the comparison of copy number aberrations (CNAs) of the @entity2 to the skin metastatic lesion that developed after progression on @entity9 , revealed high-level amplification of the 4q11-q13.1 region (containing @entity10 , @entity7 and @entity6 genes) that was sustained in both lesions. Whole exome sequencing on the germline, primary and @entity1 DNAs, resulted in 27 confirmed mutations, 19 of which (including @entity8 mutation) presented in both primary and metastatic lesions. One mutation, @entity13 frameshift deletion, was detected only in the @entity2 . In contrast, seven other mutations, including @entity11 ( @entity11 ) @entity12 mutation, were found only in the @entity1 , indicating selection of cells with the resistant genotype under @entity9 pressure. Our study supports the notion that @entity11 - @entity12 mutation may confer @entity6 -independent signaling and may thus cause resistance against @entity3 (R)-directed therapies. This case illustrates also the advantages of using next-generation technologies in identifying individualized targeted therapy.

title: XXXX ( @entity11 ) @entity12 mutation is counterselected under targeted therapy in a @entity0 with @entity4 .

answer: @entity11


abstract: OBJECTIVE: A phase II study was performed to assess the activity of @entity6 plus @entity7 ( @entity7 ) modulated by @entity9 , as second-line treatment in locally advanced or metastatic @entity5 pretreated with @entity3 -containing schedule. METHODS: @entity0 received weekly intravenous infusions of @entity6 40 mg/m, @entity7 500 mg/m, and @entity9 250 mg/m (3 weeks on, 1 week off). RESULTS: Twenty-three @entity0 affected with metastatic (16) or locally advanced (7) @entity5 were involved in this study. A total of 148 weeks of chemotherapy was delivered (median 2 courses each @entity0 ). Among 17 assessable @entity0 , no objective response was registered and 4 @entity0 had stable disease, whereas 13 had @entity1 progression. Median duration of stable disease was 14 weeks. Median @entity2 ( @entity8 ) was 11.6 weeks [95% confidence interval (CI), 7.6-5.6]. Kaplan-Meier estimated median overall survival (OS) was 17.1 week (95% CI, 4.0-30.1) and 3 months survival rate was 69.6%. Seven @entity0 experienced grade 3 to 4 @entity4 . The regimen was associated with 36% clinical benefit. CONCLUSIONS: The median @entity8 and median OS in this population with poor prognosis suggests some activity, however, only further investigations will be able to establish the clinical value of this combination.

title: @entity6 , @entity7 , and XXXX as second-line treatment for advanced pancreatic cancer.

answer: @entity9


abstract: PURPOSE: To investigate the safety of thrice-daily hyperfractionated radiotherapy (RT) given in conjunction with @entity4 ( @entity4 ) in high-grade @entity1 . METHODS AND MATERIALS: @entity0 >18 years old with newly diagnosed high-grade @entity1 were eligible. The dose of radiation was 5040 cGy, with a 1440-cGy boost in 180 cGy fractions delivered thrice daily in two 6-day periods with a 2-week interval. @entity4 (200 mg/m(2)) was administered on the first day of radiation, then every 7 weeks for 1 year and every 10 weeks for another year. RESULTS: Eighteen @entity0 were enrolled. The mean age was 49.6 years. Sixteen @entity0 had @entity3 (Grade 3 or 4 in 5 and 11 @entity0 , respectively) and 2 had @entity3 (Grade 3 and 4 in 1 @entity0 each). One underwent total resection, 9 subtotal resection, and 8 biopsy only. Thirteen @entity0 had stable disease, 4 regression, and 1 progression. The median time to progression was 37.8 weeks. The median overall survival was 44.4 weeks. Nine @entity0 had @entity2 , including 2 deaths at 69 and 139 weeks. CONCLUSION: This regimen is unacceptably toxic. Factors that could have contributed to the @entity2 may include the total radiation dose, thrice-daily hyperfractionation, and the concurrent use of i.v. @entity4 .

title: Safety of thrice-daily hyperfractionated radiation and @entity4 for high-grade XXXX .

answer: @entity1


abstract: PURPOSE OF REVIEW: Detrusor underactivity is a highly prevalent type of @entity1 in @entity0 and responsible for residual urine and decreased voiding efficiency. @entity0 with detrusor underactivity have an unfavorable outcome after prostatic surgery and do not have better long-term results than untreated detrusor underactivity @entity0 . Therefore, differentiation between detrusor underactivity and @entity3 ( @entity3 ) is crucial for the prediction of the outcome of prostatic surgery. RECENT FINDINGS: @entity0 with detrusor underactivity report more frequently about decreased/interrupted urinary flow, hesitancy, feeling of @entity2 and/or @entity2 compared with @entity0 with normal pressure-flow studies. Determination of and differentiation between detrusor underactivity and @entity3 is only possible by pressure-flow studies. Threshold values for the diagnosis of detrusor underactivity have to be adjusted to the @entity3 -grade. A nomogram using @entity3 -index and maximum Watts factor is currently the most advanced tool to diagnose detrusor underactivity and/or @entity3 ; values below the 25th percentile line indicate detrusor underactivity. It is desirable to establish tests to noninvasively diagnose detrusor underactivity. The combination of ultrasound detrusor wall thickness and bladder capacity can safely detect detrusor underactivity. SUMMARY: Careful assessment of @entity1 to discriminate between detrusor underactivity and @entity3 should be done with pressure-flow studies, can avoid unsuccessful prostate surgery and helps in counselling @entity0 .

title: Detrusor underactivity in XXXX with lower urinary tract symptoms/benign prostatic obstruction: characterization and potential impact on indications for surgical treatment of the prostate.

answer: @entity0


abstract: Transboundary @entity6 , several of which are vector borne, can maintain a dynamic focus and have pathogens circulating in geographic regions encircling multiple geopolitical boundaries. Global change is intensifying transboundary problems, including the spatial variation of the risk and incidence of @entity6 . The complexity of these challenges can be greater in areas where rivers delineate international boundaries and encompass transitions between ecozones. The Rio Grande serves as a natural border between the US State of Texas and the Mexican States of Chihuahua, Coahuila, Nuevo Le  n, and Tamaulipas. Not only do millions of @entity0 live in this transboundary region, but also a substantial amount of goods and @entity0 pass through it everyday. Moreover, it occurs over a region that functions as a corridor for animal migrations, and thus links the Neotropic and Nearctic biogeographic zones, with the latter being a known foci of @entity6 . However, the pathogenic landscape of important @entity6 in the south Texas-Mexico transboundary region remains to be fully understood. An international perspective on the interplay between disease systems, ecosystem processes, land use, and @entity0 behaviors is applied here to analyze landscape and spatial features of @entity9 , @entity1 , @entity7 , @entity5 , @entity8 , @entity4 , @entity0 @entity3 , and @entity2 . Surveillance systems following the One Health approach with a regional perspective will help identifying opportunities to mitigate the health burden of those diseases on @entity0 and animal populations. It is proposed that the Mexico-US border along the Rio Grande region be viewed as a continuum landscape where zoonotic pathogens circulate regardless of national borders.

title: Pathogenic Landscape of Transboundary XXXX in the Mexico-US Border Along the Rio Grande.

answer: @entity6


abstract: UNASSIGNED: While selective @entity5 inhibitors have demonstrated improved outcomes in @entity0 with metastatic @entity5 @entity7 mutant @entity4 , management of brain @entity1 prior to and during therapy presents challenges. Stereotactic radiosurgery (SRS) is an effective treatment for @entity4 brain @entity1 , but there is limited safety and efficacy data on the use of SRS during @entity5 therapy. An analysis was performed of @entity0 with @entity4 and brain @entity1 treated with SRS while on @entity6 . MRI scans were reviewed post-SRS to evaluate local control (LC) as well as distant control. We identified 80 metastatic @entity2 treated in 24 @entity0 . The median planning target volume was 0.28  cm(3) (range 0.05-4.19  cm(3)), and lesions were treated to a median dose of 24  Gy (range 15-24  Gy). The median follow up was 5.1  months (range 2-25.2  months). Eight (10  %) lesions showed progression at a median of 6.1  months (range 2-20.1  months) following SRS. Kaplan-Meier LC estimates at 6 and 12  months were 92 and 75  %, respectively. Fourteen (58  %) @entity0 were noted to have distant brain failure at a median of 3.4  months (range 1.9-16.1  months) following treatment with SRS. Median overall (OS) from the date of SRS was 7.2  months (range 1.5-26.8  months) with a median of 11.9  months (range 1.5-28.5  months) since the date of brain @entity1 diagnosis. There was no evidence of increased @entity3 with the combination of SRS and @entity6 . SRS to brain @entity1 appears to be both safe and effective for @entity0 treated concurrently with @entity5 inhibitors.

title: LINAC-based stereotactic radiosurgery to the brain with concurrent @entity6 for @entity4 XXXX .

answer: @entity1


abstract: PURPOSE: The purpose of this study was to evaluate the initial clinical efficacy of a retrieval stent filter for the management of @entity3 complicated with @entity1 . DESCRIPTION: The retrieval stent filter consists of two parts (ie, the filter and the Z-stent). The filter was composed of seven legs arranged in the shape of a cone with a retrieval hook at its apex. The filter and the Z-stent were connected with each other, and the retrieval of the stent filter was performed with an Amplatz gooseneck snare (MicroVena [ @entity4 Lake, MN]). Eight consecutive @entity0 were treated with the stent filters. EVALUATION: The stent filter placement was technically successful in all @entity0 . Inferior vena cavography demonstrated that all of the inferior vena cavae were patent without incidental @entity2 after deploying the stent filter. A 3-11 months follow-up study showed that all of the stent filters were removed after approximately 5 to 24 days of placement. All @entity0 were still alive with resolution of the symptoms. CONCLUSIONS: The use of a retrieval stent filter proved to be expedient, safe, and effective in the treatment of @entity3 complicated with @entity1 .

title: Retrieval stent filter: treatment of @entity3 complicated with XXXX --initial clinical experience.

answer: @entity1


abstract: Serum IgE levels and the expression of low affinity receptor for IgE ( @entity6 / @entity6 ) are increased in @entity4 . The ligation of @entity6 receptor by IgE-anti-IgE immune complexes results in @entity2 (NO) production, which is a critical leishmanicidal factor. @entity0 monocytes/macrophages express @entity6 / @entity6 after activation with @entity1 and @entity3 . In the present study, we assessed the relationship between NO, total and Leishmania-specific IgE and soluble @entity6 across the clinical spectrum of @entity4 ( @entity4 ). Sixty-nine @entity4 @entity0 and 22 endemic controls were studied. NO concentration was estimated using the Greiss method. Soluble @entity6 , total IgE and anti-Leishmania IgE levels were measured using ELISA. Soluble @entity6 was increased in the four @entity0 groups (0.001<P<0.05) compared by the Mann-Whitney test to healthy subjects, particularly in @entity8 ( @entity8 ) and @entity9 ( @entity9 ) @entity0 . Total IgE levels were higher in @entity4 @entity0 (P<0.0001). Anti-Leishmania IgE showed a similar tendency, where @entity8 and @entity9 @entity0 had greater levels. All @entity0 groups, except @entity4 ( @entity4 ) @entity0 , showed elevated levels of @entity5 /NO(3)(-) compared to healthy individuals (0.001<P<0.01). Interestingly, @entity4 @entity0 did not produce significant levels of @entity5 / @entity7 . @entity4 @entity0 showed a significant positive correlation between soluble @entity6 and anti-Leishmania IgE. @entity9 @entity0 showed a positive correlation between both parameters. Overall results suggest that sCD23, IgE and NO may play different roles across the @entity4 spectrum.

title: Variations in the serum levels of soluble @entity6 , XXXX and IgE across the spectrum of @entity4 .

answer: @entity2


abstract: OBJECTIVE: To investigate long-term psychosocial outcomes in young adults who survived @entity2 caused by @entity3 ( @entity4 ) during childhood. DESIGN: A cross-sectional study. SETTING: The psychological investigation took place in the department of @entity0 and Adolescent Psychiatry of the Erasmus MC-Sophia @entity0 's Hospital. @entity0 : All consecutive surviving @entity0 with @entity4 requiring intensive care treatment at the pediatric intensive care unit between 1988 and 2001. INTERVENTION: To explore biographical characteristics (such as living conditions, educational, occupational, and marital status) and illness-related physical or social consequences a structured interview was used. To assess intellectual functioning the Groninger Intelligence Test 2 was used and to assess @entity1 , the Adult Self-Report was used. MEASUREMENTS AND MAIN RESULTS: Fifty-eight of 83 eligible @entity2 survivors were evaluated (response rate: 70%). The @entity0 were 16-31 yrs old at time of follow-up (median age: 21 yrs old). These @entity0 had had @entity4 before 18 yrs of age. Median follow-up interval was 13 yrs, with a range of 4 to 16 yrs. For the vast majority of @entity4 @entity0 , outcomes on biographical characteristics, intellectual functioning, and levels of @entity1 were comparable to those of reference groups. A minority (5% to 20%) still report illness-related physical or social consequences, @entity1 , and lower intellectual functioning. CONCLUSIONS: Despite favorable outcomes for the majority of @entity4 @entity0 in the long term, an important minority (5% to 20%) still struggles with ongoing problems as to @entity1 , intellectual functioning, biographical characteristics, and illness-related physical or social consequences.

title: Survivors of XXXX caused by @entity3 in childhood: psychosocial outcomes in young adulthood.

answer: @entity2


abstract: PURPOSE: To evaluate technique effectiveness, safety, and interoperator performance of stereotactic radiofrequency ablation (SRFA) of @entity4 . METHODS: Retrospective review including 90 consecutive @entity0 from January 2008 to January 2010 with 106 computed tomography-guided SRFA sessions using both single and multiple electrodes for the treatment of 177 lesions: 72 @entity3 ( @entity3 ) and 105 @entity1 with a mean size of 2.9 cm (range 0.5-11 cm). Technique effectiveness and 1-year local recurrence were evaluated by computed tomographic scans. Complications, mortality, and hospital days were recorded. The performance between an experienced and inexperienced interventional radiologist was compared. RESULTS: The overall technique effectiveness after a single SRFA was 95.5% (93.1% for @entity3 and 97.1% for @entity1 ). Four of the eight unsuccessfully treated lesions could be retreated (secondary technique effectiveness of 97.7%). Local recurrence at 1 year was 2.9%. Technique effectiveness was significantly different for lesions<5 cm (96.7%) and >5 cm (87.5%) (P=0.044) but not for lesions<3 cm (95.9%) and 3-5 cm (100%). Compared to clear parenchymal property (97.3%), vessel vicinity (93.3%) (P=0.349) and subcapsular (95.2%) (P=0.532) had no, but hollow viscera vicinity (83.3%) had a significantly lower technique effectiveness (P=0.020). Mortality rate was 0.9%. Major complications and hospital days were higher for @entity2 @entity0 -Pugh B (20%, 7.2 days) than @entity0 -Pugh A (3.1%, 4.7 days) @entity0 and for @entity1 (5.1%, 4.3 days). There was no significant difference in interoperator performance. CONCLUSION: SRFA allowed for efficient, reliable, and safe ablation of large-volume @entity4 .

title: Stereotactic radiofrequency ablation (SRFA) of XXXX : technique effectiveness, safety, and interoperator performance.

answer: @entity4


abstract: @entity8 cells were normal @entity0 nasopharvngeal epithelial cells transformed by transfection with @entity5 deoxyribonucleic acid. @entity3 pituitary extract (BPE) was one of the indispensable ingredients for in vitro culture of @entity8 cells in a serum-free medium. Chromatographic fractionation of BPE and subsequent immunoblotting analyses identified the hemoglobin growth-stimulating factor. @entity7 (metHb) was then synthesized, and also found to be growth stimulating. The growth-stimulating effect of metHb was abolished when @entity8 cells were cultured in a medium that also contained @entity6 , a molecule that binds to hemoglobin. A defined medium consisting of insulin and metHb was then developed for optimal growth of @entity8 cells. MetHb kept under the conditions identical to those of cell culture released hemin which also enhanced the cell growth. Though all the degradation products of hemin are currently known to be physiologically significant. only ferric @entity2 derived from metHb or hemin could stimulate the growth of @entity8 cells. Abnormal vasculature showing leaky walls and @entity4 is a common feature of @entity1 . Hemoglobin originating from extravasated red blood cells and subsequently oxidized to metHb because of the presence of activated inflammatory cells might contribute to the increased proliferation of cancerous cells.

title: @entity7 is a supplement for in vitro culture of @entity0 nasopharyngeal epithelial cells transformed by XXXX DNA.

answer: @entity5


abstract: PURPOSE: The aim of the study was to investigate the effect of @entity1 ( @entity5 ) on @entity2 / @entity6 signaling in @entity0 gingival fibroblasts and to explore the mechanism of @entity5 induced @entity4 . METHODS: Healthy @entity0 gingival fibroblasts were cultured with different concentrations of @entity5 and the cell proliferations were assessed with CCK-8 assay. The mRNA levels of @entity2 , @entity6 and collagen I were measured by real-time PCR. The protein level of @entity2 , @entity6 , p- @entity6 and collagen I were determined using western blot and immumofluorescence. Cell migration ability was detected by cell wound scratch assay. The data was analyzed with SPSS 20.0 software package. RESULTS: The use of 200 ng/mL @entity5 stimulated proliferation and @entity3 . The mRNA levels of @entity2 and collagen I were significantly promoted after @entity5 exposure. The protein syntheses of @entity2 , p- @entity6 and Collagen I were also increased by @entity5 stimulation. CONCLUSIONS: @entity5 may activate @entity2 / @entity6 signaling pathway, thus promoting the proliferation and migration of @entity0 gingival fibroblasts as well as collagen accumulation, which eventually lead to @entity4 .

title: [Effect of @entity1 on @entity2 / XXXX signaling in @entity0 gingival fibroblasts].

answer: @entity6


abstract: BACKGROUND: The cell type responsible for the @entity7 surrounding @entity0 @entity9 is unknown. Hepatic stellate cells, which activate to a myofibroblast-like form, are responsible for collagen deposition in @entity1 and around @entity2 . Recently, pancreatic stellate cells have been described and implicated in the @entity1 of chronic @entity5 . We sought to determine whether these cells are responsible for the scirrhous reaction surrounding pancreatic @entity4 . METHODS: Archival @entity3 -fixed, @entity6 -embedded pancreatic tissues from 10 @entity0 undergoing pancreaticoduodenectomy for @entity4 and from 2 @entity0 with @entity10 were examined immunohistochemically for alpha-smooth muscle actin (alpha-SMA), @entity12 ( @entity12 ), procollagen I, collagen IV, and endothelial cell markers, @entity8 factor and cluster of differentiation 31. RESULTS: In non-neoplastic areas, staining for alpha-SMA and @entity12 was confined to interlobular septal regions. In contrast, the @entity7 surrounding all 10 pancreatic @entity4 specimens displayed intense interstitial staining for alpha-SMA, @entity12 , and collagen IV but no staining for @entity8 factor and cluster of differentiation 31. Procollagen I staining localized intracellularly to fibroblast-shaped cells within this alpha-SMA/ @entity12 -positive scirrhous region. @entity11 demonstrated an increase in alpha-SMA staining, although this was not as marked as in ductal @entity4 . CONCLUSIONS: A massive increase in myofibroblast activity, compatible with the activation of stellate cells, is associated with the deposition of collagen types I and IV in the @entity7 around pancreatic @entity4 .

title: Myofibroblasts are responsible for the @entity7 surrounding @entity0 XXXX .

answer: @entity9


abstract: BACKGROUND: @entity6 ( @entity6 ) and its antagonist @entity3 ( @entity3 ) act on the endothelial cell @entity4 receptor to regulate vascular integrity and remodeling. The local balance of these factors and the level of other angiogenic factors determine whether blood vessels grow, are maintained or regress. Profound angiogenesis and vascular remodeling occur in the placenta and this is altered in @entity5 , a major cause of maternal and fetal morbidity and mortality. MATERIALS AND METHODS: The mRNAs encoding @entity6 , @entity3 , and @entity4 were detected and localized in @entity0 placentae throughout gestation. The mechanism of regulation angiopoietin mRNAs level was determined by explant culture in ambient and reduced @entity1 , and in the presence of @entity7 . RESULTS: In situ hybridization showed that @entity3 mRNA was abundant in the syncytiotrophoblast in the first trimester of @entity0 pregnancy. @entity6 mRNA could not be detected by in situ hybridization, but was by reverse transcriptase-polymerase chain reaction (RT-PCR) and Northern blotting. Placental vascular structure is altered in @entity5 and intrauterine growth restriction, conditions where feto-placental oxygenation is perturbed. In villous explant cultures, a reduction in @entity1 tension significantly raised the levels of @entity3 mRNA, and this was dependent on transcription. However, similar experiments showed that the stability of the @entity6 message was greatly reduced under these conditions. Thus, @entity2 has opposite effects on @entity6 and @entity3 mRNA levels. Placentae obtained from @entity0 with @entity5 had reduced levels of @entity3 mRNA compared to gestationally matched controls. There was no difference in the levels of @entity6 mRNAs. CONCLUSIONS: These data show that the relative levels of @entity6 and @entity3 mRNA are regulated by local @entity1 tension by different mechanisms and that this may be important during normal @entity0 placentation.

title: The regulation and localization of angiopoietin-1, -2, and their receptor XXXX in normal and pathologic @entity0 placentae.

answer: @entity4


abstract: Regulation of apoptosis by extracellular molecules binding to cell @entity3 receptors has received much attention in recent years. Fas, a member of the @entity1 necrosis factor receptor superfamily, is a transmembrane protein whose extracellular domain binds its cognate ligand ( @entity2 ), which can induce apoptosis in sensitive cells. Fas ligation leads to activation of cell @entity3 proteases, thereby initiating a proteolytic cascade which results in cellular fragmentation and @entity3 . Apoptosis is also regulated by inhibitory signals which promote cell survival. The @entity4 family of proteins is composed of both inhibitors and activators of programmed cell @entity3 . The @entity4 protein itself inhibits many apoptotic stimuli while other members of the @entity4 family such as bak and bid promote cell @entity3 . Many types of @entity1 chemotherapy induce cellular stress leading to induction of apoptosis. Stress-activated protein kinases such as @entity6 have been shown to inactivate @entity4 through phosphorylation and induce cleavage of bid. Deficiency of proapoptotic @entity4 family members has been associated with drug-resistant phenotypes. We report that exposure of @entity0 @entity5 lines to different chemotherapy drugs activates a caspase cascade which is distinct from that of receptor-mediated apoptosis. The variable sensitivity of each @entity1 cell line to different forms of chemotherapy was not due to differences in caspase or @entity4 family protein expression. Rather, the stress-activated protein kinase @entity6 was overexpressed by resistant SCC lines which correlated with reductions in proapoptotic bid and bak protein expression. These two proteins exhibit distinct patterns of intracellular localization during chemotherapy-induced apoptosis.

title: A common pathway for chemotherapy-induced apoptosis in XXXX @entity5 lines distinct from that of receptor-mediated cell @entity3 .

answer: @entity0


abstract: PURPOSE: To investigate imaging findings in @entity1 with @entity0 ( @entity0 ). MATERIALS AND METHODS: A retrospective search in the databases of 10 radiological departments in Germany from 2000 to 2011 was performed. Only histologically proven cases of @entity0 were included into the study. Mammography was available in 31 @entity1 (33 lesions), ultrasound images in 24 @entity1 (24 lesions), and for 10 @entity1 (14 lesions) magnetic resonance imaging (MRI) of the breast was performed. The breast findings were classified according to the American College of Radiology Breast Imaging Reporting and Data Systems (BI-RADS) 5th edition categories. Collected data were evaluated by means of descriptive statistics. RESULTS: Forty-two female @entity1 (mean age 62.0 years, range, 30-86 years) were included in the study. Clinically, all @entity1 had painless lumps. Irregular (53.3% [16/30]) or oval (30.0% [9/30]) mass with indistinct (73.3% [22/30]) or microlobulated (10% [3/30]) margins were common findings on mammograms. Ultrasound revealed typically an irregular (79.2% [19/24]), hypoechoic (62.5% [15/24]) mass, with indistinct margins (79.2% [19/24]), and posterior acoustic shadowing (79.2% [19/24]). MRI showed irregular masses (81.8% [9/11]) with irregular or spiculated margins, and a rapid initial signal increase with a delayed washout in kinetic analysis. CONCLUSION: Overall, @entity0 has no pathognomonic imaging features and can mimic those of invasive @entity2 . @entity0 should be taken into the differential diagnosis of breast findings described above.

title: Imaging findings of XXXX : Results of a first multicenter study.

answer: @entity0


abstract: BACKGROUND: There is no validated case definition for @entity0 @entity5 virus-associated immune reconstitution @entity2 (IRIS). We measured the level of agreement of 2 published case definitions (hereafter referred to as @entity9 and @entity8 ) with expert opinion in a prospective cohort of @entity0 who were starting antiretroviral therapy in South Africa. METHODS: A total of 498 adult @entity0 were monitored for the first 6 months of antiretroviral therapy. All new or worsening clinical events were reviewed by 2 investigators and classified on the basis of expert opinion, @entity9 , and @entity8 . Events were categorized according to whether they were paradoxical or unmasking in presentation. We measured positive, negative, and chance-corrected agreement (kappa) with expert opinion for @entity9 and @entity8 , and reviewed areas of disagreement. RESULTS: A total of 620 clinical events were recorded, of which, on the basis of expert opinion, 144 (23.2%) were defined as probable IRIS and 112 (18.1%) were defined as possible IRIS. Of the 144 probable IRIS events, 93 (64.6%) were unmasking in presentation, 99 (68.8%) were associated with @entity3 , and 45 (31.3%) were associated with @entity4 or major @entity6 . Of the 620 clinical events recorded, 41 (6.6%) were classified as IRIS on the basis of @entity9 , and 156 (25.2%) were classified as IRIS on the basis of @entity8 . Positive agreement between @entity9 and expert opinion was low for both unmasking (17.2%; kappa = 0.24) and paradoxical events (37.3%; kappa = 0.43), mainly because 1 major criterion requires IRIS to be atypical and either an @entity6 or a @entity1 , although negative agreement was >98%. In contrast, @entity8 had good positive agreement (>75% for most event types), with a kappa value of 0.75 for paradoxical and 0.62 for unmasking. CONCLUSIONS: @entity8 agreed well with expert opinion, with additional clinical events, such as @entity7 and inflammatory dermatoses, being classified as IRIS and added to @entity8 . We propose revised case definitions for both paradoxical and unmasking IRIS.

title: Defining immune reconstitution XXXX : evaluation of expert opinion versus 2 case definitions in a South African cohort.

answer: @entity2


abstract: UNASSIGNED: Triple-negative @entity0 is a malignant @entity3 type with a high risk of early recurrence and distant @entity2 . Unlike other @entity0 , triple-negative @entity0 is lack of targetable receptors and, therefore, @entity1 largely receive systemic chemotherapy. However, inevitable adverse effects and acquired drug resistance severely constrain the therapeutic outcome. Here we tailor-designed a @entity7 -based micelle that was self-assembled from a hybrid amphiphilic polymer comprising @entity5 , @entity6 and @entity7 . The bilayer micelles can be simultaneously loaded with two chemotherapeutic drugs with synergistic @entity4 and distinct physiochemical properties, forming a uniform and spherical nanostructure. The drug-loaded micelles showed a tendency to accumulate in the @entity3 and can be internalized by @entity3 cells for drug release in acidic organelles. Under near-infrared laser irradiation, high density of self-quenched @entity8 in the hydrophobic layer absorbed light efficiently and converted into an excited state, leading to the release of sufficient heat for photothermal therapy. The integration of localized photothermal effect and synergistic chemotherapy conferred great chemosensitivity to @entity3 cells and achieved @entity3 regression using about 1/10 of traditional drug dosage. As a result, chemotherapy-associated adverse effects were successfully avoided. Our present study established a novel @entity7 -based nanoplatform with photothermal activity and expanded drug loading capacity, providing new opportunities for challenging conventional chemotherapy and fighting against stubborn triple-negative @entity0 .

title: Integration of photothermal therapy and synergistic chemotherapy by a XXXX self-assembled micelle confers chemosensitivity in triple-negative @entity0 .

answer: @entity7


abstract: PURPOSE: Ipsilateral adrenalectomy is usually performed during radical nephrectomy because of @entity4 . Because @entity3 are detected more often in the earlier stages due to widespread use of ultrasound and computerized tomography, we define a subset of @entity0 who would be eligible for adrenal sparing surgery. In a retrospective analysis we evaluated whether parameters obtained preoperatively are able to predict adrenal metastasis. MATERIALS AND METHODS: A total of 866 consecutive @entity0 who underwent nephrectomy and ipsilateral adrenalectomy from 1983 to 1999 were evaluated. Preoperative parameters, including @entity2 size, location, clinical stage, number of @entity2 , and @entity0 age and sex, were retrospectively compared with the histological results. Univariate and multivariate analyses were performed. RESULTS: A total of 27 (3.1%) adrenal @entity1 were noted in the 866 @entity0 , and 63% were on the left side and 37% on the right side. Mean @entity2 size was 10 cm. with versus 6 cm. without adrenal involvement. Of the 27 @entity0 21 had multiple @entity1 at diagnosis and only 6 (0.7% of all 866) presented with solitary ipsilateral adrenal metastasis. Univariate and multivariate analyses revealed @entity2 size and M stage as best preoperative predictors of adrenal involvement. CONCLUSIONS: Adrenal sparing surgery is possible, and we suggest a new algorithm. If maximum @entity2 size measured by computerized tomography is less than 8 cm. and staging examination does not show organ or lymph node @entity1 , adrenalectomy is not necessary because of oncological reasons. This algorithm has to be validated by a prospective analysis.

title: Adrenal sparing surgery during radical nephrectomy in XXXX with @entity4 : a new algorithm.

answer: @entity0


abstract: INTRODUCTION: In ancient and current traditional medicine in M  xico, extracts from the leaves or whole plant of 'life leaf' (Kalanchoe pinnata [K. pinnata]Lam) have been used to treat an entity known locally as 'yellow @entity1 ' (alferec  a amarilla) when it is accompanied by @entity2 . However, the anticonvulsive activity of its stems and roots remains unexplored METHODS: The anticonvulsant activity of the methanolic root extract (MER) or stem (MES) of K. pinnata Lam. was evaluated in a @entity8 -induced @entity2 model in Balb/C @entity0 , and effects were compared to those of @entity6 . The stem extract fractions that produced anticonvulsant activity were subsequently evaluated using the @entity8 -induced @entity2 model. RESULTS: We observed increased latency of @entity2 that was inversely proportional to the dose of MRE, with a similar impact on the lethal effects of @entity8 . Different doses of the @entity10 showed a dose-dependent increase in latency to @entity4 , clonus, and @entity2 , acting similarly to @entity6 and offering 100% protection against the lethal effects of @entity8 . Fractioning @entity10 decreased its effectiveness, but when fractions were mixed with fractions of @entity7 and @entity3 , anticonvulsive activity was restored. The preliminary phytochemical analysis identified alkaloids and @entity5 in MRE, and @entity5 and @entity9 in @entity10 CONCLUSIONS: The anticonvulsant activity of K. pinnata Lam. decreases with increased doses of MRE, whereas the effect of @entity10 is dose-dependent and preserved in the mixture @entity7 and @entity3 . We suggest that the metabolites responsible for these effects are @entity5 in MRE, and @entity5 and @entity9 in @entity10 .

title: Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in XXXX : A comparison to @entity6 .

answer: @entity0


abstract: In a pilot study four @entity0 with @entity4 ( @entity4 ) and @entity6 ( @entity6 ) were treated with rituximab, a B cell depicting chimeric human/mouse anti- @entity5 antibody. Treatment could be performed without serious side effects and resulted in a depletion of B cells from the peripheral blood for at least 4 months. Examination of one @entity0 three months after treatment revealed a complete depletion of B cells in the bone marrow and in the spleen as well. The time point when peripheral B cells returned into the normal range varied between 8 months and over one year and could be observed also in the spleen. The follow up over more than 12 months revealed no significant treatment-associated side effects. Total immunoglobulin and specific antibody levels did not change except for one @entity4 - @entity0 receiving additional immunosuppressive treatment including @entity1 because of progressive disease. Clinical effectiveness cannot be judged by the small number of @entity0 . However, one @entity4 @entity0 with refractory severe @entity3 had a very Favourable response with stable platelet numbers over 100.000/microl now for more than 6 months and disappearance of anti-DNA antibodies. The treatment failure in another @entity4 @entity0 could be due to the persistence of @entity5 -negative plasmablasts in peripheral blood which are not targeted by anti- @entity5 treatment. Further studies are needed to assess the clinical benefit of B cell depletion in the treatment of @entity2 .

title: Effective B cell depletion with rituximab in the treatment of XXXX .

answer: @entity2


abstract: UNASSIGNED: Parenteral antibiotic prophylaxis is the current standard of therapy in clean-contaminated @entity1 surgery. Nevertheless, the incidence of @entity2 ( @entity2 ) in oral oncological surgery is relatively high, especially in major surgery with reconstruction and tracheotomy. The aims of this study were to investigate the perioperative condition related to microorganisms in the oral cavity and to examine the efficacy of the topical administration of @entity3 in reducing the number of bacteria in the oropharyngeal fluid during intubation. The number of oral bacteria was measured during intubation in @entity0 undergoing major @entity1 surgery. The efficacy of the topical administration of @entity3 or @entity4 gel in reducing the bacteria was then investigated. Bacteria in the oropharyngeal fluid grew from 10(6)CFU/ml to 10(8)CFU/ml during the 3h after intubation (CFU, colony-forming units). When @entity3 was applied to the dorsum of the tongue, oral bacteria decreased immediately to 10(5)CFU/ml, and the number of bacteria in the oropharyngeal fluid was maintained below 10(7)CFU/ml for 7h. The concentration of @entity3 in the oropharyngeal fluid was extremely high for several hours after topical administration. The topical administration of @entity3 could reduce oral bacteria in @entity0 undergoing clean-contaminated @entity1 surgery. This method is expected to be effective in the prevention of @entity2 .

title: Efficacy of topical antibiotic administration on the inhibition of perioperative oral bacterial growth in @entity1 XXXX : a preliminary study.

answer: @entity0


abstract: BACKGROUND: A review of the nonsteroidal anti-inflammatory drug (NSAID) literature suggested occurrences of low-level incidences of @entity1 in @entity2 fetuses exposed in utero. @entity3 ( @entity3 , @entity8 ) is a widely used NSAID that irreversibly inhibits @entity10 . @entity8 has been studied extensively in @entity0 and has consistently increased low-incidence @entity1 and defects in midline closure. The objectives of the current study were to comprehensively define the developmental toxicology profile of @entity8 in @entity2 by using a dosing paradigm encompassing the period of organogenesis and to test the hypothesis that maternal @entity5 after repeated dose administrations hampers the detection of low-incidence malformations with @entity8 in @entity2 by limiting @entity8 administration to sensitive windows for cardiovascular development and midline closure. METHODS: @entity8 was administered to pregnant New Zealand White @entity2 from gestation days (GDs) 7 to 19 at dose levels of 125, 250, and 350 mg/kg per day and as single doses of 500, 750, or 1000 mg/kg on GD 9, 10, or 11. Cesarean sections were performed on GD 29, and the fetuses were examined for external, visceral and skeletal development. RESULTS: In the repeated dose study, maternal @entity4 was exhibited in the 250- and 350-mg/kg per day groups by mortality and @entity9 and body @entity7 . In the single dose studies, maternal @entity4 was exhibited at all doses by reductions in body @entity7 and food consumption for 3 days after treatment. Fetal body weight was significantly reduced in the repeated dose study at 350 mg/kg per day. Fetal weights were not affected by single doses of @entity8 on GD 9, 10, or 11. There were no treatment-related external, @entity6 associated with @entity8 administration throughout organogenesis or with single doses administered during critical developmental windows. CONCLUSION: These findings supported previous work demonstrating that @entity8 is not teratogenic in @entity2 , as opposed to @entity0 , even when large doses are administered on single days during specific windows of development.

title: Comparison of the developmental XXXX of @entity3 in @entity2 when administered throughout organogenesis or during sensitive windows of development.

answer: @entity4


abstract: BACKGROUND: @entity4 with @entity6 have clinical and pathological features that distinguish them from @entity1 . We investigated the usefulness of @entity2 status as a predictor of the benefit of adjuvant chemotherapy with @entity5 in @entity1 . METHODS: Tumor specimens were collected from @entity0 with @entity4 who were enrolled in randomized trials of @entity5 -based adjuvant chemotherapy. Microsatellite instability was assessed with the use of @entity8 and dinucleotide markers. RESULTS: Of 570 tissue specimens, 95 (16.7 percent) exhibited @entity6 . Among 287 @entity0 who did not receive adjuvant therapy, those with @entity1 displaying @entity6 had a better five-year rate of overall survival than @entity0 with @entity1 exhibiting microsatellite stability or low-frequency instability (hazard ratio for @entity3 , 0.31 [95 percent confidence interval, 0.14 to 0.72]; P=0.004). Among @entity0 who received adjuvant chemotherapy, @entity6 was not correlated with increased overall survival (hazard ratio for @entity3 , 1.07 [95 percent confidence interval, 0.62 to 1.86]; P=0.80). The benefit of treatment differed significantly according to the @entity2 status (P=0.01). Adjuvant chemotherapy improved overall survival among @entity0 with @entity1 or @entity1 exhibiting @entity7 instability, according to a multivariate analysis adjusted for stage and grade (hazard ratio for @entity3 , 0.72 [95 percent confidence interval, 0.53 to 0.99]; P=0.04). By contrast, there was no benefit of adjuvant chemotherapy in the group with @entity6 . CONCLUSIONS: @entity5 -based adjuvant chemotherapy benefited @entity0 with @entity1 with @entity1 or @entity1 exhibiting @entity7 instability but not those with @entity1 exhibiting @entity6 .

title: Tumor @entity2 status as a predictor of benefit from XXXX -based adjuvant chemotherapy for @entity4 .

answer: @entity5


abstract: Riparian buffer zones are known to reduce diffuse N pollution of streams by removing and modifying N from agricultural runoff. Denitrification, often identified as the key N removal process, is also considered as a major source of the greenhouse gas @entity3 ( @entity2 ). The risks of high @entity2 emissions during @entity0 mitigation and the environmental controls of emissions have been examined in relatively few riparian zones and the interactions between controls and emissions are still poorly understood. Our objectives were to assess the rates of @entity2 emission from riparian buffer zones that receive large loads of @entity0 , and to evaluate various factors that are purported to control N emissions. Denitrification, nitrification, and @entity2 emissions were measured seasonally in grassland and forested buffer zones along first-order streams in The Netherlands. Lateral @entity0 loading rates were high, up to 470 g N m(-2) yr(-1). @entity1 process rates were determined using flux chamber measurements and incubation experiments. @entity3 emissions were found to be significantly higher in the forested (20 kg N ha(-1) yr(-1)) compared with the grassland buffer zone (2-4 kg N ha(-1) yr(-1)), whereas denitrification rates were not significantly different. Higher rates of @entity2 emissions in the forested buffer zone were associated with higher @entity0 concentrations in the ground water. We conclude that N transformation by @entity0 -loaded buffer zones results in a significant increase of greenhouse gas emission. Considerable @entity2 fluxes measured in this study indicate that Intergovernmental Panel on Climate Change methodologies for quantifying indirect @entity2 emissions have to distinguish between agricultural uplands and riparian buffer zones in landscapes receiving large N inputs.

title: @entity3 emission and denitrification in chronically XXXX -loaded riparian buffer zones.

answer: @entity0


abstract: @entity4 ( @entity4 ) is a pregnancy associated disorder characterized by @entity1 and @entity2 , which causes neonatal and maternal morbidity and mortality. The @entity3 /Th2 cytokine paradigm of the immune adaptation in pregnancy is now expanded to include @entity3 /Th2/Th17 and regulatory T (Treg) cells. Among cytokines, @entity5 has properties that justify evaluation of its role in @entity4 etiopathology. In this investigation the polymorphisms of the @entity5 gene at promoter region, positions @entity7 and @entity6 , were studied in 142 @entity4 and 140 normal pregnant female subjects using PCR-RFLP. Additionally, serum @entity5 was determined by ELISA. At position @entity7 genotypes and allele frequencies showed no significant differences between @entity4 @entity0 (GG 73.9%; GA 21.1%; AA 4.93%) and normal control (GG 70%; GA 28.6%; AA 1.4%) @entity0 . However the AA genotype at this position was more frequent in @entity4 @entity0 than in the control group. At @entity6 position, genotypes and allele frequencies showed no significant differences between @entity4 @entity0 and control individuals. The CC genotype at @entity6 position was more prevalent in @entity4 @entity0 than in the control group. The mean serum @entity5 level was significantly higher (62.14 ng/ml) in @entity4 @entity0 compared with pregnant and non-pregnant control groups (and 47.01 and 40.68 ng/ml, respectively). In conclusion, the promoter region polymorphisms of @entity5 may not be associated with @entity4 , but serum levels of this cytokine may contribute to the etiopathology of @entity4 .

title: Promoter region polymorphisms in the @entity5 ( @entity5 ) gene and serum @entity5 concentration in preeclamptic and control Iranian XXXX .

answer: @entity0


abstract: The ability to fix the eyes on a target, visual fixation, is important for the maintenance of equilibrium. The @entity2 ( @entity2 ) test is one method of measuring the function of visual fixation. The test records @entity3 by electrooculography, and the maximum slow phase velocity of @entity3 in @entity5 is compared with the slow phase velocity in light with eyes fixed. Lesions of the cerebellum, brain stem, and cerebrum cause abnormalities of @entity2 . We report a @entity0 whose @entity2 became a clue in the diagnosis of a @entity9 . A 54-year-old @entity0 complained of @entity7 , which gradually increased in frequency over 5 months. He visited several clinics, where @entity4 and @entity8 were suspected and treated without improvement. Although a pure-tone auditory test revealed bilateral normal hearing, a caloric test showed a weak response and @entity2 was lost with augmentation of @entity3 in light on both sides. Both eye tracking and optokinetic nystagmus tests were abnormal. Although magnetic resonance imaging showed no abnormalities, single photon emission computed tomography revealed @entity6 in the parietal area. @entity2 of @entity3 towards the side of a lesion is reduced or abolished after unilateral flocculus damage, and is abolished bilaterally after bilateral flocculus damage. In the case of a parietal lobe or pontine lesion, @entity2 is strongly abolished, and even augmentation of @entity3 may be observed. In the present case, the @entity0 was diagnosed with multiple-system @entity1 after onset of @entity7 .

title: [A XXXX with Early-Stage Multiple System Atrophy Showing @entity3 in Light].

answer: @entity0


abstract: Impairment of movement execution in @entity2 could be due to @entity1 and/or of activation. These two factors are hard to separate by measuring response times only. Therefore, in this study response force and event-related EEG potentials were measured continuously during tasks in which subjects had to respond to cued signals. Fifteen @entity0 with @entity2 and 15 healthy subjects were studied during two tasks: (i) the 'clock task', in which the signal's identity was fully precued but its presentation time was uncertain and (ii) the 'validity task' in which the cue did not always predict the response validly. Thus, the clock task required more sustained attention, and the validity task sometimes required fast switching. The @entity0 generally responded slower than control subjects. In the clock task, the response times of both groups changed to the same extent with presentation time, whereas in the validity task the @entity0 were additionally slower than the control group with invalidly cued signals. The @entity0 generally had a weaker response force and a lower rate of force production. In the clock task, both force measures changed with presentation time in the control group only, whereas in the validity task, the two measures increased in both groups to the same extent with invalidly cued signals. The contingent negative variation amplitudes in the @entity0 ' event-related EEG potentials were reduced, reflecting reduced activation of movement preparation, whereas lateralization of the motor cortices (i.e. the lateralized readiness potential) did not differ significantly between groups, reflecting unimpaired response selection. Force and contingent negative variation were generally reduced in the @entity0 showing that their general slowing is at least partially due to impaired activation. Task-specific problems added to the general activation deficit; the lack of modulation of response force by presentation time revealed pronounced deficits of activation in the monotonous clock task. The specific delay of responses with invalidly cued signals, unparalleled by activation measures, might suggest a problem of cognition. The task-specific deficits may reflect a basic dilemma for @entity0 with @entity2 : @entity1 may arise in complex tasks but disorders of activation may become pronounced in more simple, monotonous tasks.

title: Responses to cued signals in XXXX . @entity1 and of activation.

answer: @entity2


abstract: The objective of the present study was to determine the effects of inhibition of @entity6 biosynthesis on fertility and embryonic survival in laying @entity1 . White Leghorn hens were fed for 5 weeks with a control diet alone or a diet supplemented with one of two concentrations (0.03 or 0.06%) of the @entity2 reductase inhibitors @entity3 , @entity5 or @entity4 . The hens were artificially inseminated once a week and eggs that were not analysed for @entity0 content were incubated. When averaged across dietary groups and expressed as a percentage of all eggs incubated, the incidence of unfertilized eggs was 1.6% (controls), 29.1% ( @entity3 ), 4.4% ( @entity5 ) and 7.9% ( @entity4 ). In contrast, with the exception of lower values for birds fed 0.06% @entity3 , all groups had comparable hatchabilities of fertilized eggs. Hatchability of all eggs incubated was decreased in both @entity3 groups compared with the other treatments. However, embryonic mortality of fertilized eggs was unaffected (P > 0.05) by diet. Compared with controls, maximum decreases in egg @entity0 of 46, 22 and 7% were obtained with @entity3 , @entity5 and @entity4 , respectively. Although the overall correlation of egg @entity0 content with hatchability was high (r = 0.82), the hatch rate of eggs containing approximately 105 mg @entity0 ranged from 0 to 67%, indicating that egg @entity0 content was not the only factor influencing embryo survival. This is the first study to indicate that a @entity6 -derived product or products plays an important role in avian fertility. In addition, this work challenges the contention that virtually all of the @entity0 in @entity1 egg yolk is essential for embryonic development and survival.

title: Relationship between inhibition of XXXX biosynthesis and reduced fertility in laying hens.

answer: @entity6


abstract: Automated immunoassay systems should be convenient to handle, flexible and give reliable results. To investigate the extent to which the UniCAP System met the above requirements, compared with the IMMULITE System, we compared the Phadiatop (UniCAP) and AlaTOP (IMMULITE) results of 110 @entity0 with positive clinical diagnoses for inhalant @entity1 . In addition, we compared food screening test results of 103 @entity0 with a clinical positive diagnosis for food, and 110 test results of controls with negative diagnosis for @entity1 . Phadiatop had a sensitivity of 96% and a specificity of 92%. AlaTOP had a sensitivity of 86% and a specificity of 94%. For food screening the results were: 75% sensitivity and 82% specificity for fx5 (UniCAP) and 63% sensitivity and 71% specificity for fp5 (IMMULITE). Furthermore, those samples for which the test results which were not in concordance with the clinical diagnosis were tested with the follow-up panel of the different screening tests. For the AlaTOP follow-up we had to use the DPC microplate System (Milenia), because single allergen testing is not yet possible on the IMMULITE System. With regard to sensitivity, the UniCAP specific inhalant allergen tests and the original Phadiatop results showed closer agreement with each other than did the Milenia specific allergen results with the AlaTOP. The specificity of the single inhalant allergen tests was the same for both systems. For @entity2 testing the UniCAP System shows closer agreement between the screening and the follow-up results than does the IMMULITE. The hands on time for loading 44 samples was practically the same for both systems, but for the follow-up tests the Milenia System is used next to the IMMULITE. Therefore from a logistical point of view the UniCAP System is more convenient. From these results we conclude that both logistically and clinically UniCAP seems to meet our requirements better than the IMMULITE.

title: The first fully automated @entity1 analyser UniCAP: comparison with IMMULITE for XXXX panel testing.

answer: @entity1


abstract: Two germicides, one containing 0.5% @entity1 and one containing 1% @entity3 , were tested for efficacy against new intramammary infections (IMI) caused by @entity0 and @entity4 . The model for the experimental challenge in the trials that were designed to test the efficacy of the two postmilking teat dips was recommended by the National @entity2 Council. The 0.5% @entity1 product reduced the number of new IMI caused by Staph. aureus by 73.2% and reduced the number of new IMI caused by Strep. agalactiae by 53.9%. The 1% @entity3 product reduced the number of new IMI caused by Staph. aureus by 75.6% and reduced the number of new IMI caused by Strep. agalactiae by 53.5%. In both trials, the incidence of clinical @entity2 was also reduced in dipped quarters compared with control quarters. Use of the two teat dips over the trial periods had no effect on the condition of teat skin or teat ends.

title: Efficacies of teat germicides containing 0.5% @entity1 and 1% XXXX during experimental challenge with @entity0 and @entity4 .

answer: @entity3


abstract: PURPOSE: The aim of this study was to ascertain recent trends in noninvasive imaging utilization for suspected @entity0 . METHODS: The Medicare Part B databases for 2001 to 2013 were reviewed. Current Procedural Terminology primary codes for radionuclide myocardial perfusion imaging (MPI), @entity1 ( @entity1 ), and coronary CT angiography (CCTA) were selected. Physician specialty codes were used to designate providers as radiologists, cardiologists, and all others as a group. Procedure volumes were tabulated, and utilization rates per 1,000 Medicare beneficiaries were calculated over the period of study. RESULTS: Total MPI utilization rates per 1,000 rose rapidly from 63.4 in 2001 to a peak of 88.0 in 2006 but declined every year thereafter, dropping to 61.9 in 2013. @entity1 rates generally held steady around 12 to 13 from 2001 to 2010 but then began to decline, reaching 10.8 in  2013. Cardiologists predominate in both MPI and @entity1 . CCTA rates were far lower. They peaked at 2.1 in 2007, but then dropped before  leveling off at 1.07 in both 2012 and 2013. Radiologists and cardiologists have approximately equal roles in this procedure. CONCLUSIONS: Both MPI and @entity1 seem to be declining in use in recent years. This is likely due to unfavorable reimbursement trends caused by code bundling and resulting in the closure of many private cardiology offices. CCTA use is far lower than the two other types of imaging and has also declined in recent years. This is puzzling, as it is a new and promising procedure that has some advantages over MPI and @entity1 . In 2013, 58 times as many MPI studies as CCTA studies were performed.

title: Recent Trends in Imaging for Suspected XXXX : What Is the Best Approach?

answer: @entity0


abstract: PURPOSE: Most studies on treatment of prosody in individuals with @entity3 due to @entity1 are based on intensive treatment of loudness. The present study investigates the effect of intensive treatment of speech rate and intonation on the intelligibility of individuals with @entity3 due to @entity1 . METHODS: A one group pretest-posttest design was used to compare intelligibility, speech rate, and intonation before and after treatment. @entity0 included eleven Dutch-speaking individuals with predominantly moderate @entity3 due to @entity1 , who received five one-hour treatment sessions per week during three weeks. Treatment focused on lowering speech rate and magnifying the phrase final intonation contrast between statements and questions. Intelligibility was perceptually assessed using a standardized sentence intelligibility test. Speech rate was automatically assessed during the sentence intelligibility test as well as during a passage reading task and a storytelling task. Intonation was perceptually assessed using a sentence reading task and a sentence repetition task, and also acoustically analyzed in terms of maximum fundamental frequency. RESULTS: After treatment, there was a significant improvement of sentence intelligibility (effect size .83), a significant increase of pause frequency during the passage reading task, a significant improvement of correct listener identification of statements and questions, and a significant increase of the maximum fundamental frequency in the final syllable of questions during both intonation tasks. CONCLUSION: The findings suggest that @entity0 were more intelligible and more able to manipulate pause frequency and statement-question intonation after treatment. However, the relationship between the change in intelligibility on the one hand and the changes in speech rate and intonation on the other hand is not yet fully understood. Results are nuanced in the light of the operated research design. LEARNING OUTCOMES: The reader will be able to: (1) describe the effect of intensive speech rate and intonation treatment on intelligibility of speakers with @entity3 due to @entity2 , (2) describe the effect of intensive speech rate treatment on rate manipulation by speakers with @entity3 due to @entity2 , and (3) describe the effect of intensive intonation treatment on manipulation of the phrase final intonation contrast between statements and questions by speakers with @entity3 due to @entity2 .

title: The effect of intensive speech rate and intonation therapy on intelligibility in XXXX .

answer: @entity1


abstract: PURPOSE: To determine the safety and outcomes of performing endovascular interventions across pacemaker (PM) lead-related central @entity4 /occlusion. MATERIALS AND METHODS: Clinical and imaging records from April 2002 to August 2010 were reviewed for @entity0 presenting with clinically significant central @entity5 or central @entity3 with indwelling PM leads and were evaluated to determine if any @entity2 or complications occurred following intervention. Thirteen @entity0 were identified who underwent 14 interventions. Outcomes were assessed based on recurrent clinical symptoms and repeat venograms, and patency was determined with Kaplan-Meier analysis. RESULTS: All procedures were technically successful (100%) with no procedural complications. All @entity0 underwent balloon angioplasty; two @entity0 also underwent stent placement for persistent flow-limiting @entity4 within the superior vena cava. No incidence of PM or @entity2 , @entity1 , or need for PM intervention was identified in any @entity0 at the time of the index procedure and at 30 or 90 days. In the two @entity0 who received stents across PM leads, no manifestations of PM or @entity2 or @entity1 , or need for intervention, were identified at 1 year after stent placement in one @entity0 and at 3 years in the other @entity0 . For eight @entity0 , sufficient follow-up studies were available, with 30-, 60-, and 120-day primary patency rates of 87.5%, 75%, and 50%, respectively. CONCLUSIONS: Endovascular interventions across PM leads resulted in no adverse clinical cardiac or PM sequelae, but with limited primary patency compared with historical outcomes for central venous interventions in the absence of PM leads.

title: Central XXXX associated with pacemaker leads: short-term results of endovascular interventions.

answer: @entity5


abstract: The present study was conducted to determine the 24, 48, 72, and 96-h median lethal concentration (LC50) of @entity3 and investigate the antioxidant response and acetylcholinesterase (AChE) activities in liver, gill, and spleen of @entity2 exposed to 0 (control), 5, and 10 mg/L @entity3 , at the fixed interval time of 24, 48, 72, and 96 h, respectively. LC50 value was 60.83 mg/L at 24 h, 51.36 mg/L at 48 h, 47.07 mg/L at 72 h and 40.13 mg/L at 96 h, respectively. Dismutase (SOD), catalase (CAT), AChE activities, and @entity0 ( @entity1 ) levels in these tissues for the control remained stable over the exposure period. However, for the two tested groups, tissue-, dose-, and time-dependent responses of these parameters were observed in @entity2 . In general, hepatic SOD and CAT activities were significantly inhibited at 24 h, activated, and increased at 48 h, but again inhibited from 48 to 96 h in fish exposed to the two tested concentrations. Hepatic @entity1 levels of fish for the two tested concentration peaked at 48 h, significantly higher than the control. Hepatic AChE activity was inhibited at 24 h, peaked at 48 h, and then declined at 72 h for the two tested groups. For gills, the highest SOD and CAT activities for the two tested groups were observed at 48 h, higher than the control. AChE activities for the two tested groups were significantly inhibited at 24 h, but activated at 48 h. At 96 h, AChE activities among the treatments showed no significant differences. Gill @entity1 levels at 48 h for the tested groups were significantly higher than the control, but showed no significant differences at 24 and 72 h among the treatments. In spleen, SOD and CAT activities at 48 h for the two tested groups were significantly higher than those in the control, but at 96 h the vice versa was true. Spleenic AChE activities and @entity1 levels for the two tested groups were inhibited at 24 h, activated at 48 h, and then were again inhibited at 72 h. Based on these observations earlier, the results obtained in our study will have important toxicological implications for waterborne @entity3 pollution and, meantime, provide the basis for the effective risk assessment of @entity3 in water environment and appropriate safety recommendations for fish.

title: Effects of waterborne @entity3 exposure on antioxidant responses and acetylcholinesterase activities in XXXX .

answer: @entity2


abstract: BACKGROUND: One of the modalities of treatment for @entity0 surgery @entity2 is opioids, and opioids are associated with adverse effects such as @entity4 (PONV). Intravenous (IV) @entity7 has been shown to reduce opioid consumption and to improve overall postoperative outcomes in abdominal surgery. In this study, we tested the effect of intraoperative IV @entity7 infusion on the quality of postoperative recovery after @entity0 surgery. METHODS: Seventy-one @entity1 undergoing @entity0 surgery were randomly assigned to receive either placebo (group P; n = 34) or IV @entity7 (group L; n = 37, bolus 1.5 mg/kg at induction, then infusion at 2 mg/kg/h, stopped 2 hours after the end of surgery) in a prospective double-blind design. Intraoperative and postoperative @entity5 consumption was calculated. @entity3 scores, PONV, and @entity6 were assessed at 2, 24, and 48 hours after surgery. Duration of postoperative hospital stay was recorded. RESULTS: Demographics were the same between the groups. There was no statistically significant difference in intraoperative or postoperative @entity5 consumption (P = 0.188 and P = 0.758) between groups. Overall @entity2 scores either at rest or activity (P = 0.348 and P = 0.810, respectively), PONV (P = 0.350), @entity6 (P = 0.758), or duration of postoperative hospital stay (P = 0.218) were not statistically different. CONCLUSIONS: Our findings did not show a significant effect of IV @entity7 during @entity0 surgery on opioid consumption, @entity2 score, PONV, or @entity6 , indicating that the benefit of this approach does not generalize across all types of surgery.

title: Effect of intravenous @entity7 on postoperative recovery of XXXX undergoing mastectomy: a double-blind, placebo-controlled randomized trial.

answer: @entity1


abstract: OBJECTIVE: This study aims to present methods and baseline data from the Early versus Late Intervention Trial with @entity2 (ELITE), the only clinical trial designed to specifically test the timing hypothesis of postmenopausal @entity1 ( @entity1 ). The timing hypothesis posits that @entity1 effects depend on the temporal initiation of @entity1 relative to time since menopause. METHODS: ELITE is a randomized, double-blind, placebo-controlled trial with a 2 * 2 factorial design. Six hundred forty-three healthy postmenopausal @entity0 without @entity3 were randomized to oral @entity2 or placebo for up to 6 to 7 years according to time since menopause (<6 or >= 10 y). @entity7 ( @entity7 ) and cardiac computed tomography were conducted to determine @entity1 effects on subclinical @entity6 across menopause strata. RESULTS: @entity0 in the early and late postmenopausal strata were well-separated by mean age (55.4 vs 65.4 y) and median time since menopause (3.5 vs 14.3 y). Expected risk factors (age, blood pressure, and body mass index) were associated with @entity7 at baseline in both strata. In the early postmenopausal group, but not in the late postmenopausal group, we observed significant associations between @entity7 and factors that may play a role in the responsiveness of @entity6 progression according to timing of @entity1 initiation. These include low-density lipoprotein @entity4 , high-density lipoprotein @entity4 , sex hormone-binding globulin, and serum total @entity2 . CONCLUSIONS: The ELITE randomized controlled trial is timely and unique. Baseline data indicate that ELITE is well-positioned to test the @entity1 timing hypothesis in relation to @entity6 progression and @entity5 .

title: Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with XXXX testing the menopausal hormone timing hypothesis.

answer: @entity2


abstract: BACKGROUND: Coagulase-negative staphylococci (CNS) are a common cause of @entity1 . In recent years, an increase in the incidence of @entity2 -resistant coagulase-negative staphylococci (MRCNS) has led to the severity of the disease. OBJECTIVES: The aim of this study was to isolate and identify MRCNS strains by @entity3 disk agar diffusion, @entity3 agar screening, and polymerase chain reaction (PCR) and to evaluate their antibacterial resistance patterns. @entity0 AND METHODS: Totally, 122 CNS isolates were collected from the clinical specimens of four hospitals in Iran. Susceptibility testing was performed by disk agar diffusion against 15 antimicrobial agents. Then, disk agar diffusion, agar screening, and PCR were applied to determine susceptibility to @entity3 . RESULTS: Out of the 122 isolates, 92 isolates were found to be MRCNS by PCR. The sensitivities and specificities of disk agar diffusion and agar screening were 89.2% and 69% and 93.8% and 96.3%, respectively. Also, 93 CNS isolates were resistant to @entity2 according to disk agar diffusion. DISCUSSION: Our results indicated that agar screening was superior to @entity3 disk agar diffusion. A comparison between the antibiotic sensitivity patterns of the MRCNS and the @entity2 -Susceptible Coagulase-Negative Staphylococci (MSCNS) showed that the MRCNS were predominantly multiple-drug resistant isolates as the simultaneous resistance rate to 4 or more antibiotics in the MRCNS and MSCNS was 93% and 56%, respectively.

title: Detection of XXXX -Resistant Coagulase-Negative Staphylococci and Surveillance of Antibacterial Resistance in a Multi-Center Study from Iran.

answer: @entity2


abstract: We wanted to determine whether allogeneic hematopoietic stem cell transplantation (HSCT) may result in long-term survival in @entity1 with solid @entity2 . HSCT was performed in 61 @entity1 with solid @entity2 : metastatic @entity6 (n  =  22), @entity3 (n  =  17), @entity5 (n  =  15), @entity4 (n  =  3), @entity7 (n  =  3), or @entity0 (n  =  1). Liver transplantation was performed for @entity2 debulking in 18 @entity1 . Median age was 56  years (range, 28 to 77). Donors were either HLA-identical siblings (n  =  29) or unrelated (n  =  32). Conditioning was nonmyeloablative (n  =  23), reduced (n  =  36), or myeloablative (n  =  2). Graft failure occurred in 13 @entity1 (21%). The cumulative incidence of @entity9 ( @entity9 ) of grades II to IV was 47%, and that of chronic @entity9 was 32%. Treatment-related mortality was 21%. At 5  years @entity2 -related mortality was 63%. Currently, 6 @entity1 are alive, 2 with @entity8 , 1 with @entity3 , and 3 with @entity10 . Eight-year survival was 12%. Risk factors for mortality were nonmyeloablative conditioning (HR, 2.95; P  <  .001), absence of chronic @entity9 (HR, 3.57; P  <  .001), acute @entity9 of grades II to IV (HR, 2.90; P  =  .002), and HLA-identical transplant (HR, 5.00; P  =  .03). With none of these risk factors, survival at 6  years was 50% (n  =  6). Long-term survival can be achieved in some @entity1 with solid @entity2 after HSCT.

title: Long-Term Follow-Up of Allogeneic Hematopoietic Stem Cell Transplantation for Solid XXXX .

answer: @entity2


abstract: BACKGROUND: The macrofollicular variant of @entity7 that is the subject of this study has only recently been characterized. Information about its morphologic spectrum and biologic behavior is limited. METHODS: The authors reviewed 29 examples, including 17 previously reported cases. The clinical and pathologic features of five @entity0 who had the macrofollicular variant of @entity7 with a @entity5 were analyzed in detail. The insular component in @entity4 has been associated with @entity3 clinical behavior. RESULTS: The ages of the 5 @entity0 ranged from 31 to 70 years; the mean age was 40 years. Three @entity0 presented with a palpable thyroid nodule and two with a large thyroid mass of long duration. The latter two @entity2 , which metastasized, were the largest (8 and 11 cm) and showed @entity6 . All five @entity2 were composed predominantly of macrofollicles (>50%) and had a @entity5 that comprised less than 5% of the @entity2 mass. In most @entity2 , the macrofollicles were lined by cells with large, clear, grooved nuclei, and all five contained areas of conventional follicular variant of @entity7 . In the two that metastasized, however, the lining of many macrofollicles consisted of cuboidal cells with small, hyperchromatic, follicular-type nuclei. Only the macrofollicular component was identified in the metastatic deposits in these two @entity0 . All five @entity0 were alive at last follow-up, two with @entity1 ; but follow-up for this study is limited. CONCLUSIONS: A @entity5 is an additional feature of the macrofollicular variant of @entity7 that may aid in diagnosis and does not appear to have an adverse effect on the excellent prognosis of @entity0 with these @entity2 .

title: Macrofollicular variant of @entity7 with XXXX .

answer: @entity5


abstract: PURPOSE: @entity1 dogma dictates that the physiologic response to injury is blunted by beta-blockers and other cardiac medications. We sought to determine how the @entity1 cardiac medication profile influences admission physiology and post-injury outcomes. MATERIALS AND METHODS: @entity1 @entity0 older than 45 evaluated at our center were retrospectively studied. Pre-injury medication profiles were evaluated for angiotensin-converting enzyme inhibitors / angiotensin receptor blockers (ACE-I/ARB), beta-blockers, @entity2 channel blockers, @entity5 , or a combination of the above mentioned agents. Multivariable logistic regression or linear regression analyses were used to identify relationships between @entity1 medications, vital signs on presentation, @entity4 , length of hospital stay, and mortality. RESULTS: Records of 645 @entity0 were reviewed (mean age 62.9 years, Injury Severity Score >10, 23%). Our analysis demonstrated no effect on @entity3 from beta-blocker, ACE-I/ARB, @entity2 channel blocker, and @entity5 use. The triple therapy (combined beta-blocker, @entity2 channel blocker, and ACE-I/ARB) @entity0 group had significantly lower heart rate than the no cardiac medication group. No other groups were statistically different for heart rate, systolic, and diastolic blood pressure. CONCLUSIONS: Pre-injury use of cardiac medication lowered heart rate in the triple-agent group (beta-blocker, @entity2 channel blocker, and ACEi/ARB) when compared the no cardiac medication group. While most combinations of cardiac medications do not blunt the hyperdynamic response in @entity1 cases, @entity0 on combined beta-blocker, @entity2 channel blocker, and ACE-I/ARB therapy had higher mortality and more in-hospital complications despite only mild attenuation of the hyperdynamic response.

title: Pre-injury beta blocker use does not affect the hyperdynamic response in older XXXX @entity0 .

answer: @entity1


abstract: UNASSIGNED: Type 2 @entity0 is a very prevalent @entity3 . Among dietary factors for its prevention and treatment, interest has grown in satiating fibre (konjac glucomannan) and spirulina. Our previous studies suggest that glucomannan itself and/or in conjunction to spirulina displayed hypolipemic and antioxidant effects when incorporated to squid surimi as functional ingredients. The present study aims to determine whether @entity10 - enriched or glucomannan plus spirulina-enriched squid-surimi improve plasma @entity4 and insulin levels in Zucker fa/fa @entity1 fed a high saturated fat diet. Twenty four growing @entity1 , divided into three groups, were given modified AIN-93M diets for seven weeks: 30% squid-surimi control diet (C), 30% glucomannan-enriched squid-surimi diet (G) and 30% glucomannan plus spirulina-enriched squid-surimi diet ( @entity6 ). All @entity1 became @entity7 and hyperinsulinemics, but G and @entity6 diets induced significantly lower @entity4 levels (20%; p < 0.05) but did not modify insulinemia with respect to C diet. @entity6 animals showed higher HOMA-D (p < 0.05) than C ones suggesting @entity2 . Plasma @entity9 and adiponectin decreased in G and @entity6 vs. C group (p < 0.05). Adipose adiponectin increased significantly in G and @entity6 vs. C @entity1 (16-20 times, p < 0.01). @entity9 in adipose tissue was higher in @entity6 vs. G group (p < 0.05). In conclusion, both glucomannan-diets were able to reduce @entity8 and increase adipose tissue adiponectin levels in fa/fa @entity1 , suggesting an anti- @entity5 and insulin-sensitizing adipokine effect in this tissue. Spirulina inclusion @entity2 . Although results are promising, the utility of consuming glucomannan surimis as part of usual diets demands future studies.

title: GLUCOMANNAN AND GLUCOMANNAN PLUS SPIRULINA-ENRICHED SQUID-SURIMI ADDED TO HIGH SATURATED DIET AFFECT GLYCEMIA, PLASMA AND ADIPOSE @entity9 AND ADIPONECTIN LEVELS IN GROWING FA/FA XXXX .

answer: @entity1


abstract: OBJECTIVE: To assess the efficacy and tolerability of @entity4 20mg daily, for the treatment of @entity2 and @entity2 associated with @entity1 . METHOD: An open, non-comparative study undertaken at three centers in three cities of Pakistan. A total of 112 in- or out- @entity0 , presenting with a major @entity2 were included in the study. @entity2 was diagnosed according to DSM IV criteria and a Hamilton Rating Scale for @entity2 (HAMD-D) score of >18 on the first 17 items of the HAM-D-21. After a placebo washout period of 7 days, @entity0 were given a 20-mg fixed dose of @entity4 daily in the morning for a period of 6 weeks. After baseline, regular assessments were made at 1, 2, 4 and 6 weeks. Efficacy measures included the HAMD-D, the Clinical Anxiety Scale, The Clinical Global Impression Severity of Illness Scale (CGI-S), and the Clinical Global Impression Improvement Scale (CGI-I). Tolerability was assessed by any adverse event. The primary therapeutic outcome measures were @entity0 who achieved a 50% or greater reduction in HAMD-D score at the end of the treatment or achieved a reduction in final HAMD-D score of < or = 10 points. The final scores of 1 or 2 for CGI-S and CGI-I were considered as full clinical response. RESULTS: Of 112 cases evaluated, 57 were males and 55 females whose ages ranged from 18 to 65 years. There was a clear and statistically significant efficacy of @entity4 on all the major outcome variables. A total of 88% @entity0 achieved a reduction in the final HAMD-D score at the end of treatment. The total HAM-D score reduced to 10 or less in 73% @entity0 at 6 weeks and by this week 76% and 92% @entity0 achieved a score of 1 or 2 for CGI-S and CGI-I, respectively. The mean Clinical Anxiety Scale score reduced from 12.6 at the baseline to 4.4 at the end of treatment. Safety data was evaluated in all 112 @entity0 and @entity4 was well tolerated. Adverse events were experienced by 10% of @entity0 of whom 4% were dropped from the study. @entity3 was the commonest adverse event reported. CONCLUSION: The study shows that @entity4 is an effective, well-tolerated, and safe drug for the treatment of @entity2 .

title: Efficacy and tolerability of @entity4 20 mg daily in the treatment of @entity2 and XXXX associated @entity1 .

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: One of the most cellular source used for cartilage tissue engineering are mesenchymal stem cells (MSCs). In present study, @entity0 MSCs were used as cellular source. Since scaffold plays an important role in tissue engineering the aim of this study is to assess fibrin scaffold ability in chondrogenic differentiation of adipose-derived mesenchymal stem cells (ADMSCs). METHODS: ADMSCs were isolated and cultured in DMEM medium supplemented with 10% @entity4 . Also ADMSCs expanded and characterised by flow cytometry. ADMSCs expressed @entity2 , @entity5 , CD105 but not @entity3 . After trypsinization, cells were entered within the fibrin scaffold. Then, chondrogenic medium was added to the scaffold. Seven days after cell culture, cell viability and proliferation were assessed by @entity1 test. Finally, 14 days after the ending of chondrogenic differentiation, analysis of chondrogenic genes expression was evaluated by RT-PCR and Real time PCR. Also, formation and development of chondrocyte cells was analysed by histological and immunohistochemistry evaluations. RESULTS: Viability and proliferation as well as chondrogenic genes expression within fibrin scaffold increased significantly compared with control group (cells free scaffold). Also, histological and immunohistochemistry evaluation showed that chondrocyte cells and collagen type II are formed on fibrin scaffold. CONCLUSIONS: Fibrin is a suitable scaffold for chondrogenic differentiation of ADMSCs.

title: Fibrin Scaffolds Designing in order to XXXX Adipose-derived Mesenchymal Stem Cells Differentiation to Chondrocytes in the Presence of TGF-b3.

answer: @entity0