abstract: UNASSIGNED: This study aimed to review the clinical features and outcome of 53 @entity0 with @entity5 managed at our Institution between 1976 and 2012. Thirty-five @entity0 had @entity2 and 18 extramedullary @entity5 . @entity1 sizes were larger in @entity0 with bone involvement (P  =  0  003). Treatment consisted of local radiotherapy (n  =  26), radiotherapy  +  chemotherapy (n  =  15), surgery (n  =  4) and chemotherapy (n  =  8); the local control rate was 94  3%. Progression to multiple @entity4 was recorded in 20/35 (57  1%) @entity0 with bone involvement and in 1/18 (5  5%) @entity0 with extramedullary disease (P  =  0  0003). The 5-year @entity3 ( @entity3 ) rate was 78  4%; @entity2 @entity0 had a significantly worse @entity3 (71  9% vs. 88  2%, respectively; P  =  0  029) and 5-year progression-free survival (PFS; 53  0% vs. 88  5%; P  =  0  0003) compared to extramedullary @entity5 @entity0 . On univariate analysis, @entity2 and size (>= 5  cm) impacted negatively on PFS (P  =  0  0027 and P  =  0  04, respectively). @entity2 also affected @entity3 (P  =  0  04). In multivariate analysis bone location was the only independent prognostic factor for PFS (P  =  0  0041) and @entity3 (P  =  0  021). @entity0 with @entity2 have a significantly worse prognosis than extramedullary @entity5 cases.

title: Clinical features and prognostic factors in XXXX .

answer: @entity5


abstract: PURPOSE: To determine the clinical efficacy of diffusion-weighted and perfusion echo-planar magnetic resonance (MR) imaging in the evaluation of @entity8 . MATERIALS AND METHODS: Seventeen @entity0 with @entity8 were examined prospectively with diffusion-weighted and perfusion echo-planar MR imaging and conventional angiography. The change in the effective transverse relaxation rate (delta R2*) peak value, delta R2* peak time, and delta R2* integral were calculated to assess regional cerebral perfusion. The MR images were compared with angiographic images. RESULTS: Of the 34 posterior cerebral arteries (PCAs) of the 17 @entity0 , 14 PCAs (41%) in 11 @entity0 showed @entity4 or @entity3 . The delta R2* peak value ratio in the cerebral hemispheres decreased significantly, and the delta R2* peak time ratio increased significantly, with @entity7 and @entity3 . However, no correlation was apparent between perfusion and extent of the stenotic or occlusive lesions of the internal carotid artery bifurcation. The frequency of @entity2 was significantly increased in @entity0 with stenotic or occlusive @entity1 . For three acute @entity5 , a decrease in the apparent diffusion coefficient was significantly correlated with a decrease in the delta R2* peak value, an increase in the delta R2* peak time, and a decrease in the delta R2* integral. CONCLUSION: Regional cerebral perfusion in @entity8 is decreased and delayed with @entity7 , with greater decrease and delay with @entity3 . Diffusion-weighted and perfusion imaging are useful for evaluating @entity6 in @entity8 .

title: XXXX : evaluation with diffusion-weighted and perfusion echo-planar MR imaging.

answer: @entity8


abstract: James' adaptation of the Glasgow @entity1 scale (JGCS) was designed for young @entity0 . Intubated @entity0 are not allocated a verbal score, however, so important changes in a @entity0 's conscious level may be missed. A grimace score was therefore developed and assessed for use in intubated @entity0 . Two observers made a JGCS observation within 15 minutes of each other. One observer was the @entity0 's nurse and the other a trained investigator. Interobserver reliability was determined between the first and second observation for each component of the scale. Reliability was measured using kappa and weighted kappa statistics. Seventy three @entity0 had 104 sets of observations. Interobserver reliability was moderate to good for all components, with the grimace score better than the verbal score. It is concluded that the grimace score is more reliable than the verbal score and may be useful in intubated @entity0 in whom the verbal score cannot be used.

title: Development of a modified paediatric XXXX scale in intensive care clinical practice.

answer: @entity1


abstract: BACKGROUND: In 2002, an increased risk of @entity1 was reported for sons of @entity0 exposed to @entity2 ( @entity3 ) in utero, suggesting transgenerational effects of @entity3 . The aim of this study was to further assess the association between parental @entity3 exposure and @entity1 in a case-referent study. METHODS: Cases with @entity1 were retrieved from the hospital information system. Referents were recruited via the parents of cases. Both parents completed postal questionnaires. Associations were estimated by odds ratios (OR) with 95% confidence intervals (CI). Additionally, conditional logistic regression analyses were performed for a matched subset of parents. RESULTS: The final database included 583 cases and 251 referents. In the initial analyses, an indication was found for an increased risk of @entity1 when mothers were exposed to @entity3 in utero: OR=2.3 (95% CI 0.7-7.9). Conditional logistic regression resulted in a stronger risk estimate: OR=4.9 (95% CI 1.1-22.3). Paternal exposure to @entity3 did not increase the risk. CONCLUSIONS: The results confirm an increased risk of @entity1 when mothers were exposed to @entity3 in utero. However, the excess risk appears to be of much smaller magnitude than in the 2002 study. Further research on the potential health risks for the third generation is of great importance.

title: @entity1 : a transgenerational effect of XXXX ?

answer: @entity2


abstract: The intestinal protozoan @entity2 is a widespread opportunistic parasite of @entity0 and animals. This parasite inhabits the upper part of the small intestine and has a direct life cycle. After ingestion of cysts, which are the infective stage, the trophozoites emerge from the cysts in the duodenum and attach to the small intestinal mucosa of the host. Since the migration of trophozoites from the lumen of the intestine into surrounding tissues is an unusual occurrence, the immune response to Giardia remains localized. The identification of antigens that play a role in acquired immunity has been difficult because of the occurrence of antigenic variation and because, Giardia being an ubiquitous organism, it is possible that the antigenic profiles of isolates from different geographic areas will vary. Innate-immunity mechanisms play a role in the control and/or severity of the @entity1 . Both humoral and cell-mediated immune responses play a role in acquired immunity, but the mechanisms involved are unknown. A variety of serological assays have been used to detect circulating antibodies in serum. Because of the biological characteristics of the parasite and the lack of suitable antigens, the sensitivity of serological assays remains poor. On the other hand, detection of antigens in feces of infected @entity0 has met with success. Commercial kits are available, and they are reported to be more sensitive than microscopic examination for the detection of @entity3 on a single specimen.

title: Immune response to XXXX .

answer: @entity2


abstract: Anti-nucleosome antibodies have a role in the diagnosis and follow-up of @entity3 ( @entity3 ) and have a possible correlation with @entity3 activity and with kidney and hematological involvement. The aim of our study was to detect in 91 @entity0 with @entity1 ( @entity1 ) the positivity of anti-nucleosome antibodies during therapy with three different @entity2 blocking agents and to underline the possible correlation with the development of antinuclear autoantibodies (ANA) and anti-dsDNA autoantibodies. We detected anti-nucleosome antibodies, ANA, and anti-dsDNA during therapy with three different @entity2 blocking agents at T-0 and after 12 and 24 weeks of treatment, respectively. Anti-nucleosome antibodies (IgG class) were analyzed by ELISA technique (Orgentec Diagnostika GmbH, Mainz, Germany), ANA both by indirect immunofluorescence (IIF) technique on Hep-2 (Scimedx, USA) and by ELISA (Autoimmune EIA ANA screening test Bio-Rad Laboratories, CA, USA), and anti-dsDNA (IgG and IgM classes) by ELISA (Kallestad, Bio-Rad Laboratories, CA, USA) and confirmed by IIF on Crithidia luciliae (ImmunoConcepts N.A., Sacramento, CA, USA). We observed 19 @entity0 on infliximab treatment at 3 mg/kg every 8 weeks, 43 @entity0 on etanercept treatment at 25 mg twice a week, and 29 @entity0 on adalimumab treatment at 40 mg every other week. At baseline, we observed positivity as follow: in the group of @entity0 treated with infliximab-anti-nucleosome 1/19 (5.26%), ANA 3/19 (15.7%), anti-dsDNA 1/19 (5.26%); in the group treated with etanercept--anti-nucleosome 2/43 (4.65%), ANA 1/43 (2.43%), anti-dsDNA 0/43; and in the group treated with adalimumab--anti-nucleosome 2/29 (6.89%), ANA 1/29 (3.44%), anti-dsDNA 0/29. The results at 12 weeks for the three autoantibodies were: for infliximab--3/19 (15.7%), 10/19 (52.6%), 2/19 (10.5%); for etanercept--3/43 (6.9%), 10/43 (23.2%), 1/43 (2.32%); and for adalimumab--3/29 (10.3%), 4/29 (13.7%), 1/29 (3.4%). At 24 weeks, the results were for infliximab 6/19 (31.5%), 12/19 (63.1%), 2/19 (10.5%); for etanercept 11/43 (25.5%), 22/43 (51.1%), 2/43 (4.65%); and for adalimumab 4/29 (13.7%), 13/29 (44.8%), 1/29 (3.4%). We observed a concordance anti-nucleosome/ANA antibodies of 85.5% (p < 0.001). Our data showed a concordance between anti-nucleosome antibodies and ANA positivity in @entity0 with @entity1 during therapy with @entity2 blocking agents. The induction of autoantibodies positivity is different for each @entity2 blocking agent.

title: Anti-nucleosome antibodies as prediction factor of development of autoantibodies during therapy with three different @entity2 blocking agents in XXXX .

answer: @entity1


abstract: BACKGROUND: In @entity6 ( @entity6 ), conventional lifestyle modification measures such as dietary counseling and exercise are supplemented with relaxation techniques and psychological motivational elements. This review studied the effect of @entity6 on @entity2 and mortality in @entity0 with @entity3 ( @entity3 ). METHODS: This review is based on publications up to and including January 2015 that were retrieved by a systematic search in PubMed, the Cochrane Library, and Scopus. Randomized controlled trials of the effect of @entity6 programs (versus standard treatment) on @entity2 , overall mortality, and/or cardiac mortality were analyzed. @entity4 , blood pressure, LDL @entity1 , and the body mass index (BMI) were chosen as secondary outcomes. Random-effects meta-analyses were performed. The risk of bias was assessed with the Cochrane tool. RESULTS: Twelve trials, performed on a total of 1085 @entity0 , were included in the analysis. Significant differences between groups were found with respect to @entity2 (odds ratio [OR]: 0.38; 95% confidence interval [CI]: 0.23-0.61; p<0.01; heterogeneity [I2]: 0%), but not overall mortality (OR: 0.82; 95% CI: 0.46-1.45; p = 0.49; I2: 0%) or cardiac mortality (OR: 0.98; 95% CI: 0.43-2.25; p = 0.97; I2: 0%). Significant differences between groups were also found with respect to @entity4 (mean difference [MD] = -7.86% diameter @entity5 ; 95% CI: -15.06-[-0.65]; p = 0.03; I2: 0%) and systolic blood pressure (MD = -3.33 mm Hg; 95% CI: -5.76-[-0.91]; p<0.01; I2: 0%), but not with respect to diastolic blood pressure, LDL @entity1 , or BMI. CONCLUSION: In @entity0 with @entity3 , @entity6 programs can lessen the occurrence of @entity2 , reduce @entity4 , and lower systolic blood pressure, but they do not reduce mortality. They can be used as a complement to conventional rehabilitation programs.

title: Mind-Body Medicine in the Secondary Prevention of XXXX .

answer: @entity3


abstract: Numerous microRNAs (miRNAs), small non-coding RNAs encoded in the @entity0 genome, have been shown to be involved in @entity1 pathogenesis and progression. There is evidence that some of these miRNAs possess proapoptotic or proliferation promoting roles in the cell by negatively regulating target mRNAs. Oncogenic viruses are able to produce persistent @entity3 , favoring @entity1 development by deregulating cell proliferation and inhibiting apoptosis. It has been recently suggested that cellular miRNAs may participate in host-virus interactions, influencing viral replication. Many @entity0 viruses counteract this cellular antiviral defense by using viral proteins but also by encoding viral miRNAs involved in virus-induced @entity2 . Interferons (IFNs) modulate a number of non-coding RNA genes, especially miRNAs, that may be used by @entity0 organisms as a mechanism of IFN system to combat @entity5 . In particular, IFNs might induce specific cellular miRNAs that target viral transcripts thereby using this strategy as part of their effectiveness against invading viruses. Therefore IFNs, interferon stimulated genes and miRNAs could act synergistically as innate response to @entity4 to induce a potent non-permissive cellular environment for virus replication and virus-induced @entity1 . The relevance of this reviewed research topic is clearly related to the observation that although @entity4 are responsible of specific @entity1 , other unidentified genetic alterations are likely involved in the induction of malignant transformation. The identification of such genetic alterations, i.e. miRNA expression in transformed cells, would be of considerable importance for the analysis of the pathogenesis and for the treatment of @entity1 induced by specific viruses as well as for the advancement of the current knowledge on the molecular mechanisms underlying virus-host interaction. In this respect, we will review also the important, still little explored, roles of miRNAs acting both as IFN-stimulated anti-viral molecules and as critical regulators of IFNs and IFN-stimulated genes.

title: MicroRNAs in virus-induced XXXX and IFN system.

answer: @entity2


abstract: OBJECTIVES: @entity5 is a rare primary @entity2 that differs from @entity3 in several aspects. The aim of this study was to describe the clinical, surgical and histopathological features of @entity5 and to analyze the factors associated with survival. METHODS: We identified 21 @entity0 with histopathologically diagnosed @entity5 over a 22-year period. Clinical information was collected from medical records and biopsies, and surgical specimens were reviewed. RESULTS: The median age at diagnosis was 20 years. Most @entity0 were female (67%) and did not have associated @entity4 . Most @entity0 had a single nodule, and the median @entity1 size was 120 mm. Vascular invasion was present in 31% of @entity0 , and extra-hepatic metastases were present in 53%. Fourteen @entity0 underwent surgery as the first-line therapy, three received chemotherapy, and four received palliative care. Eighteen @entity0 had "pure @entity5 ," whereas three had a distinct area of @entity3 and were classified as having "mixed @entity5 ." The median overall survival was 36 months. The presence of "mixed @entity5 " and macrovascular invasion were predictors of poor survival. Vascular invasion was associated with an increased risk of recurrence in @entity0 who underwent surgery. CONCLUSION: @entity5 was more common in young female @entity0 without @entity4 . Surgery was the first therapeutic option to achieve disease control, even in advanced cases. Vascular invasion was a risk factor for @entity1 recurrence. The presence of macrovascular invasion and areas of @entity3 were directly related to poor survival.

title: Clinical and pathological evaluation of XXXX : a single center study of 21 cases.

answer: @entity5


abstract: AIM: The aim was to examine trends in socio-demographic differences in the prevalence of @entity2 and @entity1 among the Lithuanian adult population from 1994 to 2014. METHODS: The data from 11 postal surveys were analysed. For every survey, a nationally representative random sample aged 20-64 was drawn from the National Population Register. The sample consisted of 3000 individuals in each of the 1994-2008 surveys and 4000 in the last three surveys. Altogether, 8738 @entity0 and 11,822 @entity0 participated in the surveys. Self-reported weight and height were used to calculate BMI. RESULTS: From 1994 to 2014, the prevalence of @entity2 and @entity1 increased in all socio-demographic groups of @entity0 , reaching 58.6% and 19.5% respectively. Highly educated @entity0 and those living in cities had higher BMI values than lower educated and non-urban inhabitants without substantial changes in the differences in BMI over the study period. In @entity0 , the prevalence of @entity2 decreased from 51.7% to 46%, whereas the prevalence of @entity1 did not change being 19.2% in 2014. Overweight and @entity1 were more common among lower educated @entity0 and those living in non-urban areas than in the others. Educational inequalities in weight status of @entity0 increased due to the decrease of BMI only in @entity0 with university education. CONCLUSIONS: Time trends in BMI were more pronounced among Lithuanian @entity0 than @entity0 , whereas socio-demographic inequalities were greater among @entity0 . The strategies for prevention and control of @entity1 should target all @entity0 and @entity0 with lower education and living in non-urban areas of Lithuania.

title: Socio-demographic inequalities in @entity2 and XXXX among Lithuanian adults: time trends from 1994 to 2014.

answer: @entity1


abstract: BACKGROUND: The detection of BRAFV600 mutations in @entity0 with @entity3 is important because of the availability of @entity5 inhibitor therapy. However, the clinical relevance of the frequency of BRAFV600 mutant alleles is unclear. @entity0 AND METHODS: Allele frequencies of BRAFV600 mutations were analyzed by ultra-deep next generation sequencing in @entity4 -fixed, @entity6 -embedded @entity3 tissue (75 primary @entity3 and 88 matched @entity1 ). In a second study, pretreatment specimens from 76 @entity0 who received @entity5 inhibitors were retrospectively analyzed, and BRAFV600 allele frequencies were correlated with therapeutic results. RESULTS: Thirty-five @entity0 had concordantly @entity5 -positive and 36 (48%) @entity0 had concordantly @entity5 -negative primary @entity3 and matched @entity1 , and four @entity0 had discordant samples with low allele frequencies (3.4-5.2%). Twenty-six of 35 @entity0 with concordant samples had BRAFV600E mutations, three of whom had additional mutations ( @entity8 in two @entity0 and @entity9 in one) and nine @entity0 had exclusively non- @entity7 mutations ( @entity8 in eight @entity0 and @entity7 - @entity10 - in one @entity0 ). The frequency of mutated BRAFV600 alleles was similar in the primary @entity3 and matched metastasis in 27/35 @entity0 , but differed by >3-fold in 8/35 of samples. BRAFV600E allele frequencies in @entity2 specimens were not significantly correlated with treatment outcomes in 76 @entity0 with @entity3 who were treated with @entity5 inhibitors. CONCLUSIONS: BRAFV600 mutation status and allele frequency is consistent in the majority of primary @entity3 and matched @entity1 . A small subgroup of @entity0 has double mutations. BRAFV600 allele frequencies are not correlated with the response to @entity5 inhibitors.

title: Allele frequencies of BRAFV600 mutations in primary @entity3 and matched @entity1 and their relevance for XXXX inhibitor therapy in @entity3 .

answer: @entity5


abstract: OBJECTIVE: To investigate delays in the presentation to hospital and evaluation of @entity0 with suspected @entity1 . DESIGN: Multicentre prospective observational study. SETTING: 22 hospitals in the United Kingdom and Dublin. @entity0 : 739 @entity0 with suspected @entity1 presenting to hospital. MAIN OUTCOME MEASURES: Time from onset of @entity1 symptoms to arrival at hospital, and time from arrival to evaluation by a senior doctor. RESULTS: The median age of @entity0 was 75 years, and 400 were @entity0 . The median delay between onset of symptoms and arrival at hospital was 6 hours (interquartile range 1 hour 48 minutes to 19 hours 12 minutes). 37% of @entity0 arrived within 3 hours, 50% within 6 hours. The median delay for @entity0 using the emergency service was 2 hours 3 minutes (47 minutes to 7 hours 12 minutes) compared with 7 hours 12 minutes (2 hours 5 minutes to 20 hours 37 minutes) for referrals from general practitioners (P<0.0001). Use of emergency services reduced delays to hospital (odds ratio 0.45, 95% confidence interval 0.23 to 0.61). The median time to evaluation by a senior doctor was 1 hour 9 minutes (interquartile range 33 minutes to 1 hour 50 minutes) but was undertaken in only 477 (65%) @entity0 within 3 hours of arrival. This was not influenced by age, sex, time of presentation, mode of referral, hospital type, or the presence of a @entity1 unit. Computed tomography was requested within 3 hours of arrival in 166 (22%) @entity0 but undertaken in only 60 (8%). CONCLUSION: Delays in @entity0 arriving at hospital with suspected @entity1 can be reduced by the increased use of emergency services. Over a third of @entity0 arrive at hospital within three hours of @entity1 ; their management can be improved by expediting medical evaluation and performing computed tomography early.

title: A multicentre observational study of presentation and early assessment of acute XXXX .

answer: @entity1


abstract: BACKGROUND: @entity1 (POI) is the predominant cause of extended hospitalization after bowel resection surgery. @entity3 accelerates gastrointestinal recovery, potentially reducing health care costs. We examined the value of @entity3 in reducing prolonged POI and length of stay for @entity0 undergoing abdominal surgery using different definitions of POI. STUDY DESIGN: We developed a decision analytic model to examine costs and outcomes associated with postoperative treatment with either an @entity2 ( @entity2 ) only or @entity3 + @entity2 . To represent an overall perspective for @entity3 , data from four phase 3 bowel resection trials and one phase 4 radical cystectomy trial were used to populate the model with 3 different definitions of POI. The period analyzed included start of surgery to 7 days post discharge. Costs were obtained from standard US costing sources and are reported in 2015 US dollars. Due to variations in published definitions of POI, alternative definitions based on adverse event reports, NG tube insertion, and time to food toleration were examined. RESULTS: The combined clinical trial data included 1,003 @entity2 and 1,013 @entity3 + @entity2 @entity0 . When POI was reported as an adverse event, the incidence of POI was significantly lower with @entity3 + @entity2 (n  = 70 [7%]) vs @entity2 alone (n  = 148 [15%]; p < 0.0001). Time to discharge order written was shorter for @entity0 with POI who were treated with @entity3 + @entity2 than with @entity2 (202    115 hours vs 266    138 hours; p < 0.0001). As a result, costs were  731 lower with @entity3 + @entity2 ( 17,835) vs @entity2 ( 18,566). Alternative definitions of POI produced similar results. CONCLUSIONS: The addition of @entity3 to existing treatment pathways for @entity0 undergoing abdominal surgery can reduce overall hospital costs.

title: Economic Impact of XXXX Considering Varying Definitions of @entity1 .

answer: @entity3


abstract: @entity3 ( @entity2 ) is a leading cause of serious @entity1 . In this study we determine the prevalence, serotype distribution and genomic diversity of @entity2 in vagina of pregnant @entity0 . Vaginal swabs of 531 pregnant @entity0 were cultured on Columbia Agar Base Blood, @entity2 Agar Base and Todd Hewitt Broth. @entity2 were characterized by group and type-specific agglutination. Genomic polymorphism was studied by random amplification of DNA (RAPD). Seventeen @entity0 (3.2%) were positive for @entity2 , resulting serotype III the most frequent. RAPD detected 16 different RAPD profiles from 21 @entity2 studied, revealing a good discriminatory power. In this sense, this method showed different genotype from @entity2 serotype III recovered from successive samples of two @entity0 , suggesting reinfection. In conclusion, the combination of RAPD and serotyping appear promising for epidemiological studies. Finally, findings of reinfection after therapy during pregnancy, led us to suggest performing prenatal @entity2 screening and intrapartum prophylaxis in order to reduce neonatal risk.

title: Phenotypic and genotypic study of @entity3 in vagina of pregnant XXXX in Argentina.

answer: @entity0


abstract: PURPOSE: The primary goal was to describe the injury patterns in a population of primary (first time) lateral patellar dislocators (LPD) to lend clarity to commonly held notions about injury patterns in this population. METHODS: A prospective study identifying @entity0 presenting with LPD between 2008 and 2012. Inclusion criteria were a history and physical exam consistent with primary LPD, and an MRI consistent with the diagnosis without other significant @entity2 . On MRI, location of cartilage, medial patellofemoral ligament (MPFL) injury, and bone @entity4 were noted. Severity was categorized as partial or complete for MPFL and cartilage lesions. @entity5 patellar instability risk factors ( @entity8 , @entity6 , @entity1 , and lateral patella tilt) were recorded and compared to the injury patterns. RESULTS: This study involved 157 @entity0 ; 107 @entity0 were skeletally mature. Of the 157 @entity0 , 26 had surgery for this injury due to clinician-perceived need for cartilage debridement. MPFL injury severity was @entity3 (N   =   69, 44%), partial (N   =   67, 43%), and none (N   =   19, 13%). MPFL injury location was isolated femoral (N   =   16, 10%), isolated patella (N   =   26, 17%), isolated mid-substance (0%), multiple locations (N   =   95, 61%), and none (N   =   20, 13%). @entity2 location was patella (N   =   67, 43%), lateral femoral condyle (N   =   11, 7%), multiple locations (N   =   53, 34%), and none (N   =   26, 17%). A majority (61%) of patellar chondral lesions were at its inferomedial aspect; all medial patellar retinacular partial injuries involved the inferomedial aspect of the patella, consistent with the insertion of the medial patellotibial ligament (MPTL). Skeletally immature @entity0 had a greater risk of isolated patellar MPFL and @entity2 . No clear relationship was found between/across the location and/or severity of bone @entity4 , MPFL, or @entity2 . CLINICAL RELEVANCE: Underlying anatomic patellar instability risk factors defined by MRI, do not predict injury patterns. MPFL and @entity2 , as well as bone @entity4 , are common following LPD. The medial patellotibial ligament is torn in patellar-based medial retinacular injuries, based on MRI injury location. Skeletal immaturity plays a role in the location of the injury pattern with isolated patellar-based MPFL/ @entity2 being more common in the skeletally immature @entity0 . Sex does not appear to be a factor in injury patterns after primary LPD. Knowledge of these injury trends will help focus the clinician in injury evaluation when managing primary @entity7 . LEVEL OF EVIDENCE: Case series, Level IV.

title: XXXX patellar instability risk factors in primary @entity7 do not predict injury patterns: an MRI-based study.

answer: @entity5


abstract: UNASSIGNED: 7556 Background: Prognostic index for second-line chemotherapy of @entity2 was previously developed, based on individual @entity0 data (IPD) of 9 randomized trials (Table) (Di Maio et al, Eur J Cancer 2010; 46: 735-743). In this study, we aimed to validate the prognostic score, with the use of an external dataset. METHODS: We analyzed IPD of @entity0 (pts) enrolled in a non-inferiority phase III trial comparing @entity4 vs. @entity3 in second-line treatment of advanced @entity2 . The study showed similar efficacy for both agents. Primary endpoint of this analysis was overall survival (OS). The following variables were considered for survival analysis and score calculation: gender, performance status (PS), extent of disease, @entity1 histotype, type of first-line treatment, response to first-line treatment. Cox model, stratified by treatment arm, was used for multivariate analysis. Individual prognostic scores were derived according to our scoring system, and pts were divided into 3 categories according to the score: <5 (best), 5-9 (intermediate), >9 (worst). RESULTS: All 551 pts enrolled in the trial had complete information for prognostic score calculation. Median OS in all pts was 6.9 months. Median OS was 12.9, 6.9 and 3.8 months for the best, intermediate and worst categories, respectively. Cox model analysis showed a significant effect for intermediate vs. best category comparison (hazard ratio 1.79, 95%CI 1.31 - 2.47, p=0.0003) and for worst vs. best category comparison (hazard ratio 3.25, 95%CI 2.18 - 4.83, p<0.0001). The C-index of the model was high (0.926), indicating a good discrimination according to the proposed risk categories. CONCLUSIONS: Prognostic ability of our score for candidates to second-line treatment in advanced @entity2 was validated. Subgroups of @entity0 with more vs. less favorable prognosis were identified. Prognostic score could be useful in clinical practice. [Table: see text].

title: Prognostic score for second-line chemotherapy of advanced @entity2 ( @entity2 ): External validation in a phase III trial comparing XXXX with @entity3 .

answer: @entity4


abstract: PURPOSE: The production and administration of drugs used intrathecally requires special care to prevent contamination with @entity6 agents. In 2007, we investigated a widespread outbreak of @entity2 and @entity4 among Chinese @entity0 who received intrathecal drugs to identify the presumed contaminant and its source to prevent further cases. @entity0 AND METHODS: We defined a case as onset from January 1 to October 31, 2007, of bilateral flaccid @entity4 or @entity2 or retention and incontinence of stool or urine, in a @entity0 receiving intrathecal drugs. Using a retrospective cohort approach, we selected 12 hospitals from all hospitals that had reported cases. In these hospitals, we identified all 448 @entity0 (including 107 cases) who received intrathecal chemotherapy or chemoprophylaxis in 2007. We calculated attack rates and Mantel-Haenszel adjusted risk ratios for intrathecal drug type and lot. RESULTS: All 12 hospitals used intrathecal @entity3 or @entity7 produced by one pharmaceutical plant. Only two lots of each drug were associated with cases. Lot-specific attack rates ranged from 42% to 100% (risk ratio,    ; lower confidence bounds, 1.8 to 7.3). @entity5 production had immediately preceded production of the implicated lots on the same equipment. By using ultra performance liquid chromatography, we detected @entity5 (0.28 to 18  g) in unused vials from implicated lots of @entity3 and @entity7 . CONCLUSION: Trace amounts of @entity5 that contaminated intrathecal drugs caused a large outbreak of severe @entity1 . @entity5 and other @entity6 drugs should not be produced on any equipment that is also used for producing drugs that are to be administered intrathecally.

title: XXXX and @entity4 from intrathecal @entity3 and @entity7 contaminated with trace amounts of @entity5 in China during 2007.

answer: @entity2


abstract: PURPOSE: To determine the efficacy and safety of infliximab in the treatment of refractory posterior @entity2 . DESIGN: Noncomparative interventional case series. @entity0 : Five @entity0 with posterior @entity2 were treated: 3 had Beh  et's syndrome, and 2 had @entity4 . INTERVENTIONS: @entity0 with sight-threatening @entity2 refractory to other immunosuppressive agents were treated with infliximab. MAIN OUTCOME MEASURES: Intraocular inflammation, by using binocular indirect ophthalmoscopy score, @entity3 , and visual acuity. Adverse effects of infliximab were documented. RESULTS: Within 2 weeks of the first infusion of infliximab, 4 of 5 @entity0 showed marked improvement in vitreous haze and visual acuity. By the 6-month follow-up, the same four @entity0 had achieved remission of posterior @entity2 and had successfully withdrawn all other immunosuppressive therapy. Further infusions of infliximab were required in 3 @entity0 . One @entity0 developed @entity5 , which responded to antituberculous treatment. CONCLUSIONS: Infliximab is effective in the treatment of sight-threatening refractory posterior @entity2 . However, @entity0 should be thoroughly screened for @entity1 before treatment and followed up closely during and after therapy with infliximab.

title: Infliximab in the treatment of refractory posterior XXXX .

answer: @entity2


abstract: BACKGROUND: Jumping translocations (JT) are uncommon cytogenetic abnormalities involving nonreciprocal translocations of a single donor chromosome onto 2 or more chromosomes. The clinical characteristics and prognosis of JTs in @entity0 with @entity1 are not well described. MATERIALS AND METHODS: We searched our cytogenetic database from 2003 to 2014 to identify cases of @entity1 associated with a JT. These cases were cross-referenced with our clinical databases to determine @entity0 characteristics, response to treatment and overall survival. RESULTS: We identified 10 @entity0 with @entity1 and a JT: 4 cases of @entity3 with @entity2 -related changes, 4 cases of @entity2 , and 2 cases of postpolycythemia @entity4 . The donor segment was derived from chromosome 1 in every case. The acquisition of a JT was a late occurrence, with a median time to JT development of 24.9 months (range, 0-248 months) from diagnosis. The overall response to treatment was poor, with no @entity0 experiencing a response to conventional chemotherapy or hypomethylating agents. The median overall survival for the group was 9 months (95% confidence interval, 2.5-15.5) after identification of a JT. CONCLUSION: The acquisition of a JT in @entity0 with @entity1 appears to be a late event and is associated with @entity2 . In our series, this was associated with a poor prognosis with a poor response to treatment, disease transformation to @entity3 , and short overall survival.

title: Jumping Translocations in XXXX Associated With Treatment Resistance and Poor Survival.

answer: @entity1


abstract: Mitogen-activated protein kinase (MAPK) cascades play pivotal roles in plant innate immunity. Overexpression of StMEK1( @entity4 ), a constitutively active MAPK kinase that activates @entity9 -induced protein kinase (SIPK) and wound-induced protein kinase (WIPK), provokes @entity0 in Nicotiana benthamiana. Here we purified a 51-kD MAPK, which was activated in @entity5 ( @entity5 ) tubers treated with hyphal wall elicitor of a plant pathogen, and isolated the cDNA designated @entity11 . The deduced @entity6 sequence of the @entity11 showed strong similarity to stress-responsive MAPKs, such as @entity3 ( @entity3 ) SIPK and @entity7 ( @entity7 ) @entity10 . To investigate the downstream signaling of @entity11 , we identified several proteins phosphorylated by @entity11 (PPSs) using an in vitro expression cloning method. To dissect the biological function of PPSs in the plant defense, we employed virus-induced gene silencing (VIGS) in N. benthamiana. VIGS of NbPPS3 significantly delayed cell @entity1 induced by the transient expression of StMEK1( @entity4 ) and treatment with hyphal wall elicitor. Furthermore, the mobility shift of NbPPS3 on @entity2 - @entity8 gel was induced by transient expression of StMEK1( @entity4 ). The mobility shift of NbPPS3 induced by StMEK1( @entity4 ) was not compromised by VIGS of WIPK or SIPK alone, but drastically reduced by the silencing of both WIPK and SIPK. This work strongly supports the idea that PPS3 is a physiological substrate of @entity11 and is involved in cell @entity1 activated by a MAPK cascade.

title: Involvement of PPS3 phosphorylated by elicitor-responsive mitogen-activated protein kinases in the regulation of plant cell XXXX .

answer: @entity1


abstract: @entity7 (cADPR) is a novel cyclic @entity2 derived from @entity4 that has now been established as a general @entity0 messenger in a wide variety of cells. Despite the obvious importance of monitoring its cellular levels under various physiological conditions, its measurement has been technically difficult and requires specialized reagents. In this study a widely applicable high-sensitivity assay for cADPR is described. @entity3 - @entity6 cyclase normally catalyses the synthesis of cADPR from @entity4 , but the reaction can be reversed in the presence of high concentrations of @entity5 , producing @entity4 from cADPR stoichiometrically. The resultant @entity4 can then be coupled to a cycling assay involving @entity1 dehydrogenase and @entity9 . Each time @entity4 cycles through these coupled reactions, a molecule of highly fluorescent @entity8 is generated. The reaction can be conducted for hours, resulting in more than a thousand-fold amplification of cADPR. Concentrations of cADPR in the nanomolar range can be measured routinely. The unique ability of @entity3 - @entity6 cyclase to catalyse the reverse reaction provides the required specificity. Using this assay, it is demonstrated that cADPR is present in all tissues tested and that the levels measured are directly comparable with those obtained using a radioimmunoassay. All the necessary reagents are widely available and the assay can be performed using a multiwell fluorescence plate reader, providing a high-throughput method for monitoring cADPR levels. This assay should be valuable in elucidating the messenger role of cADPR in cells.

title: A novel cycling assay for cellular XXXX with nanomolar sensitivity.

answer: @entity7


abstract: @entity6 has the worst prognosis of all @entity1 with a dismal 5-year survival rate. Hence, there is a tremendous need for development of new and effective therapy for this @entity1 . In an earlier study we reported a potent antitumor activity of @entity9 (AuriPE) against @entity6 . In addition, we have also reported that @entity8 (bryo1) induces @entity7 cells, but the effect of bryo1 has not been investigated in @entity6 . This is the first report where we demonstrate that bryo1 induces differentiation and potentiates the antitumor effect of AuriPE in a @entity0 @entity6 (PANC-1) xenograft model. A xenograft model was established by injecting the PANC-1 cells s.c. in @entity5 ( @entity5 ) @entity2 . After development of the s.c. @entity1 , @entity1 were dissected and small fragments were transplanted in vivo to new @entity5 @entity2 , with a success rate of 100% and a doubling time of 4.8 days. The @entity5 @entity2 xenograft model was used to test the in vivo differentiation effect of bryo1 and its efficacy when given alone or in combination with AuriPE. Sections from paraffin-embedded @entity1 excised from untreated (control) @entity5 @entity2 revealed typical poorly differentiated @entity4 . Interestingly, sections of s.c. @entity1 taken from bryo1-treated @entity2 revealed @entity3 that were much lower grade and less aggressive, and displayed prominent squamous and glandular differentiation. In this study, the @entity1 growth inhibition (T/C), activity score and cure rate for bryo1, AuriPE and bryo1+AuriPE were 80%, (+) and 0/4; 0.0%, (++++) and 3/5; and 0.0%, (++++) and 3/4, respectively. @entity2 treated with either AuriPE or bryo1+AuriPE were free of @entity1 for more than 150 days and were considered cured. The use of bryo1 as a novel differentiating agent and its combination with AuriPE should be further explored for the treatment of @entity4 .

title: XXXX induces differentiation and potentiates the antitumor effect of @entity9 in a @entity0 @entity6 (PANC-1) xenograft model.

answer: @entity8


abstract: CONTEXT: Assessment techniques used to measure functional tasks involving active trunk control are restricted to linear movements that lack the explosive movements and dynamic tasks associated with activities of daily living and sport. Reliable clinical methods used to assess the diagonal and ballistic movements about the trunk are lacking. OBJECTIVE: To assess the interday reliability of peak muscular power outputs while @entity0 performed diagonal @entity1 and lift tests and maintained a stable trunk. DESIGN: Controlled laboratory study. SETTING: University research laboratory. @entity0 OR OTHER @entity0 : Eighteen healthy individuals (10 @entity0 and 8 @entity0 ; age = 32    11 years, height = 168    12 cm, mass = 80    19 kg) from the general population participated. INTERVENTION(S): @entity0 performed 2 power tests ( @entity1 , lift) using an isotonic dynamometer and 3 endurance tests (Biering-S  rensen, side-plank left, side-plank right) to assess active trunk control. Testing was performed on 3 different days separated by at least 1 week. Reliability was compared between days 1 and 2 and between days 2 and 3. Correlations between the power and endurance tests were evaluated to determine the degree of similarity. MAIN OUTCOME MEASURE(S): Peak muscular power outputs (watts) derived from a 1-repetition maximum protocol for the @entity1 and lift tests were collected for both the right and left sides. RESULTS: Intraclass correlation coefficients for peak muscular power were highly reliable for the @entity1 (range, 0.87-0.98), lift (range, 0.83-0.96), and endurance (range, 0.80-0.98) tests between test sessions. The correlations between the power assessments and the Biering-S  rensen test (r range, -0.008 to 0.017) were low. The side-plank tests were moderately correlated with the @entity1 (r range, 0.528-0.590) and the lift (r range, 0.359-0.467) tests. CONCLUSIONS: The diagonal @entity1 and lift power protocol generated reliable data and appears to be a dynamic test that simulates functional tasks, which require dynamic trunk control.

title: Interday reliability of peak muscular power outputs on an isotonic dynamometer and assessment of active trunk control using the XXXX and lift tests.

answer: @entity1


abstract: AIM: This retrospective study aimed to investigate the effect of @entity7 ( @entity7 ) in the management of @entity2 @entity0 with internal fixation instrument exposure caused by early @entity1 after open reduction and internal fixation (ORIF). METHODS: Fourteen @entity0 (11 @entity0 , 3 @entity0 , age range 9-63 years) with spinal and extremities @entity2 were enrolled in this study, including atlanto-axial @entity2 (N.=1), thoraco-lumbar @entity2 (N.=1), humerus @entity2 (N.=1), @entity6 (N.=2), humerus @entity2 together with @entity6 (N.=1), @entity2 of @entity4 and @entity8 (N.=3), L1 @entity2 together with @entity4 and @entity8 @entity2 (N.=2), L1 @entity2 (N.=2) and L1 @entity2 complicated by @entity5 (N.=1). @entity3 occurred at the surgical incisions 1-7 days after ORIF operation. Deep spread of the infection caused exposure of internal fixation device. All @entity0 underwent local debridement with retention of internal fixation device. @entity7 foam dressings containing the drainage tube were placed into the wound, covering external fixation devices and fully eliminating the dead space of soft tissue to avoid effusion. Continuous drainage and @entity7 irrigation was performed for 24 h with regular replacement of @entity7 . RESULTS: After 14-43 days of @entity7 treatment, internal fixation devices were covered by healthy granulation tissue and complete wound healing was achieved. During a postoperative follow-up period of between 2 to 52 months, physical examinations and imaging studies of all @entity0 showed good functional recovery, no loosening of internal fixation devices, and no @entity3 . CONCLUSION: The use of @entity7 , while retaining the internal fixation device can be safe and effective with earlier wound healing and functional recovery.

title: Application of @entity7 in the treatment of internal fixation instrument exposure after early XXXX .

answer: @entity1


abstract: UNASSIGNED: Sequential endocrine therapy (ET) is recommended for postmenopausal @entity1 with hormone receptor-positive (HR+)/ @entity1 epidermal growth factor receptor 2-negative ( @entity4 -) metastatic @entity0 (mBC) and without visceral symptoms. Chemotherapy (CT) can be considered after sequential ETs, but is associated with adverse side effects. We assessed physicians' preferences and self-reported prescribing patterns for ET and CT in the treatment of HR+/ @entity4 - mBC at community practices in the United States. Community-based oncologists/hematologists from a nationwide online panel who treated postmenopausal @entity1 with HR+/ @entity4 - mBC were invited to complete a survey, blinded to the identity of study sponsor. Treatment preferences were collected by treatment class of ET-based regimens versus CT and by agent for postmenopausal HR+/ @entity4 - mBC @entity1 after prior nonsteroidal aromatase inhibitor use in the adjuvant or mBC setting. Among 213 physicians who completed the survey, 78% were male, 71% were based in small/intermediate practices (2-9 oncologists/subspecialists), 55% had >10  years of experience, and 58% referred to the National @entity2 Network Guidelines when treating mBC. Among first-line ETs, @entity6 was the most frequently used treatment (35%), followed by @entity5 -based (EVE, 34%) and @entity3 -based (FUL, 15%) therapy. After first-line ET, the most preferred second- and third-line treatments were ET monotherapy (48% and 39%), ET combination therapy (31% and 19%), and CT monotherapy (13% and 30%). Comparing EVE versus FUL, physicians preferred EVE in all lines but first line. Efficacy was the most important consideration for treatment choice. Physicians prescribed CT in early lines mainly because of visceral symptoms. This survey of treatment patterns for HR+/ @entity4 - mBC in community practice suggested that after first-line ET, ET mono- or combination therapy was commonly used for the second- and third-line treatments and CT monotherapy for third- or later line treatments. CTs were used in early lines for @entity1 with visceral symptoms.

title: Physician experiences and preferences in the treatment of HR+/ @entity4 - metastatic XXXX in the United States: a  physician survey.

answer: @entity0


abstract: This multicenter phase I/II study investigated the maximum tolerated dose ( @entity10 ), safety, and efficacy of low dose intravenous (IV) @entity8 in combination with @entity7 for @entity0 with relapsed @entity6 ( @entity6 ). @entity0 received @entity7 1.3 mg/m(2) on days 1, 4, 8, and 11 and escalating doses of IV @entity8 (2.5-10.0 mg/m(2)) on day 2 of a 28-day cycle for a maximum of eight cycles. @entity3 20 mg was added for progressive or stable disease. Fifty-three @entity0 were enrolled. The @entity10 was defined at @entity8 7.5 mg/m(2) and @entity7 1.3 mg/m(2). The overall response rate (ORR) was 68% (23% complete or near-complete responses [ @entity9 ]) whilst at the @entity10 (n = 33) the ORR was 76% (34% @entity9 ). After median follow-up of 17 months, the median progression free survival was 10 months, rising to 12 months at the @entity10 (P < 0.05 vs. non- @entity10 regimens). The median overall survival was 28 months, but was not yet reached at the @entity10 . Grade 3/4 adverse events included @entity4 (62%), @entity5 (57%), @entity2 (21%), and @entity1 (15%). @entity7 and low-dose IV @entity8 combination therapy is a safe and highly effective regimen for @entity0 with relapsed @entity6 . These data suggest further investigation of this combination is warranted.

title: @entity7 , low-dose intravenous @entity8 , and XXXX for @entity0 with relapsed @entity6 .

answer: @entity3


abstract: We present a case in which @entity4 was applied for @entity2 following the administration of @entity8 . An emergency surgery under general anesthesia was planned for a 43-year-old male @entity0 due to an L1 vertebral corpus and right tibia-fibula shaft fracture. Anesthesia was induced with @entity6 , @entity3 and @entity5 . After applying only 30mg of the total induction dose of @entity4 , it was learned that the neurological examination should be controlled again from the surgeon because of the controversial of the @entity1 . As a result, @entity0 awakened from anesthesia. We administered 2mg/kg @entity8 and spontaneous breathing of @entity0 returned immediately. The @entity0 became conscious and orientated immediately afterwards. The neurological examination of the lower extremities was performed. The @entity0 was anesthetized once again and 0.6mg/kg @entity4 was given in order to gain neoromuscular block approximately 10min after @entity8 administration. 2min later, the @entity0 was smoothly intubated. Neuromuscular monitorization was not used because of emergency. We administered 2mg/kg @entity8 at the end of the procedure and the @entity0 was extubated. The most suitable time for the re-establishment of @entity4 following @entity8 is currently unclear. This case showed that @entity7 can be effectively re-induced by @entity4 following the reversal of @entity4 -induced @entity7 with @entity8 . In this case, we consider that the ability to effectively reuse normal induction doses of @entity4 is an important clinical observation.

title: Case report: @entity7 induced by XXXX following @entity8 administration.

answer: @entity4


abstract: The fumigant activity of essential oil vapors distilled from sweet basil Ocimum basilicum L. and spearmint Mentha spicata L. (Lamiaceae) were tested against two major stored products pests Ephestia kuehniella (Zeller) and Plodia interpunctella (H  bner) (Lepidoptera: Pyralidae). Various oil doses (0.5, 2.5, 5, 50, 250, 500, 1,000, and 1,500   l/liter air), for an exposure period of 24   h, were tested. The essential oils were subjected to gas chromatography-mass spectrometry analysis and revealed that the major compounds were for spearmint oil @entity4 (67.1%) and @entity1 (+1,8 cineole; 14.3%) and for basil oil @entity3 (45.9%), 1,8 cineole (16.7%) and @entity2 (10.3%). Apart from a few exceptions, no significant differences in insecticidal action were observed between basil and spearmint oil. Both oils were highly effective against adult moths, given that notable mortality (>80%) was recorded after exposure to low doses such as 2.5     l/liter. Noteworthy, egg mortality was also recorded, reaching 73-79% for basil and 56-60% for spearmint. @entity0 data indicated that larvae and pupae were the most tolerant stages in all cases. Larval mortality never exceeded 21 and 18%, for basil and spearmint, respectively, irrespective of moth species. Basil and spearmint oils displayed mortalities as high as 38 and 28% in pupae. Lethal doses (LD50 and LD99) values were estimated via probit analysis. Developmental stage proved to be a significant factor, whereas the effect of oil species on insect mortality was insignificant. With the exception of adult individuals, basil and spearmint oils did not show satisfactory overall insecticidal activity against E. kuehniella and P. interpunctella.

title: Fumigant XXXX of Essential Oils from Basil and Spearmint Against Two Major Pyralid Pests of Stored Products.

answer: @entity0


abstract: UNASSIGNED: Deep brain stimulation (DBS) of the nucleus accumbens (NAc) has been applied to attenuate drug relapses in animal studies and clinical treatments. However, the mechanisms by which DBS produces its therapeutic effects remain largely unknown. This study is the first to combine @entity1 -enhanced magnetic resonance imaging (MRI) with DBS to explore the effects of accumbal DBS on the relapse pathway of @entity0 . The images suggested that DBS produced an antidromic activation of the cortico-accumbal afferents. To verify the activating effects of DBS, the expression levels of the protein encoded by the immediate early gene @entity6 following DBS were measured using immunochemical methods. Intra-shell DBS increased @entity6 expression at the site of stimulation as well as in the infralimbic prefrontal cortex (IL), and increased @entity6 -expressing GABAergic interneurons in the IL. This activity is consistent with a previous study demonstrating that DBS of the NAc shell attenuated @entity4 reinstatement via local activation and/or the activation of GABAergic interneurons in the medial prefrontal cortex (mPFC). For further examination, @entity5 was microinjected into the NAc shell to block the fibers during DBS before the reinstatement test. Inactivation of the target fibers attenuated the effects of DBS on the reinstatement of @entity3 seeking. Moreover, @entity2 receptor antagonists administered into the IL weakened the effect of DBS, while @entity2 receptor agonists microinjected into the IL attenuated the reinstatement of @entity3 seeking.

title: Exploring the mechanism by which accumbal deep brain stimulation attenuates XXXX -induced reinstatement through @entity1 -enhanced MRI and pharmacological intervention.

answer: @entity3


abstract: PURPOSE: Sequence variations in the @entity3 ( @entity3 ) gene account for approximately 2% to 4% of @entity1 cases. One particular @entity3 mutation, @entity4 (dbSNP accession number: @entity5 ), is the most common genetic mutation causing @entity1 by @entity2 (IOP). The objective of this study was to evaluate the effect of this @entity3 mutation on IOP using data from large-scale European population panels (directly sequenced and imputation based). DESIGN: Cross-sectional, cohort study. @entity0 : For this study, the penetrance of the variant @entity5 was estimated in 2 population-based cohorts, the TwinsUK (N = 6092) and the Rotterdam Study (RS) (N =11 189). METHODS: Carriers of the risk allele for @entity5 were identified using whole-genome sequencing and imputation data (based on 1000 Genomes Project and Haplotype Reference Consortium panels). The penetrance of this variant was evaluated using IOP measurements and data on visual field testing/a diagnosis of @entity1 (if available). MAIN OUTCOME MEASURES: The penetrance of the variant @entity5 was estimated from the percentage of the carriers of the risk allele of the variant who had high IOP ( @entity2 ) or @entity1 . RESULTS: In our study, the observed penetrance of the variant @entity5 in relation to increased IOP was 12.5% and 19.4% in the TwinsUK and the RS, respectively. Thus, our study suggests a much lower penetrance for @entity5 for @entity2 (and thus @entity1 ), in comparison with that reported previously. CONCLUSIONS: The significance of this finding is that higher numbers of healthy individuals in the population are expected to be carriers of this mutation, which in turn reduces the utility of identifying carriers of this mutation as a screening tool for @entity1 .

title: Evaluation of the @entity3 Mutation Gln368Stop Demonstrates Reduced Penetrance for XXXX .

answer: @entity1


abstract: OBJECTIVE: To assess the impact of electronic health record (EHR) implementation on primary care @entity1 care. DATA SOURCES: Charts were abstracted semi-annually for 14,051 @entity1 @entity0 seen in 34 primary care practices in a large, fee-for-service network from January 1, 2005 to December 31, 2010. The study sample was limited to @entity0 aged 40 years or older. STUDY DESIGN: A naturalistic experiment in which GE Centricity Physician Office-EMR 2005 was rolled out over a staggered 3-year schedule. DATA COLLECTION: Chart audits were conducted using the AMA/Physician Consortium Adult @entity1 Measure set. The primary outcome was the HealthPartners' "optimal care" measure: HbA1c  <= 8 percent; LDL @entity3 < 100 mg/dl; blood pressure < 130/80 mmHg; not smoking; and documented @entity2 use in @entity0 >=  40 years of age. PRINCIPAL FINDINGS: After adjusting for @entity0 age, sex, and insulin use, @entity0 exposed to the EHR were significantly more likely to receive "optimal care" when compared with unexposed @entity0 (p < .001), with an estimated difference of 9.20 percent (95% CI: 6.08, 12.33) in the final year between exposed @entity0 and @entity0 never exposed. Components of the optimal care bundle showing positive improvement after adjustment were systolic blood pressure <80 mmHg, diastolic blood pressure <130 mmHg, @entity2 prescription, and smoking cessation. Among @entity0 exposed to EHR, all process and outcome measures except HbA1c and lipid control showed significant improvement. CONCLUSION: Implementation of a commercially available EHR in primary care practice may improve @entity1 care and clinical outcomes.

title: The effectiveness of implementing an electronic health record on XXXX care and outcomes.

answer: @entity1


abstract: OBJECTIVE: The aim of the study was to evaluate systematic thyroid ultrasonography (US) relevance in newly diagnosed @entity2 among @entity0 presenting without palpable @entity3 . SUBJECTS AND METHODS: We consecutively recruited 208 cases of @entity2 without palpable @entity3 . All @entity0 were screened for thyroid antibodies and underwent a thyroid US. Ultrasonically guided biopsy was proposed for the assessment of all @entity3 upper or equal to 10mm in diameter. RESULTS: Two third of @entity0 had an @entity1 requiring an US. One third of @entity0 had a normal thyroid at palpation and US was consequently unwarranted. Among all @entity0 , US detected non-palpable @entity3 in 26% of cases. We found no smears suspected to be cancerous. CONCLUSIONS: In newly diagnosed @entity2 , the US relevance is only questionable in @entity0 without @entity1 . Ultrasonography detected non-palpable @entity3 and none was suspected to be cancerous. These data suggest that US is not useful in @entity0 without @entity1 . Nevertheless, the recent Thyroid Imaging-Reporting And Data System classification (TI-RADS) might change our conclusions. The TI-RADS classification indeed improves the selection of @entity3 lower than 10mm in diameter requiring a biopsy. Nodules lower than 10mm in diameter were not biopsied in the present study. The other US data presented herein (echogenicity, vascularisation) provide no further relevance for systematic US in newly diagnosed @entity0 .

title: Screening for thyroid cancer according to French recommendations with thyroid ultrasound in newly diagnosed XXXX without palpable @entity3 is not useful.

answer: @entity2


abstract: PURPOSE: To investigate the correlations in target volumes based on @entity3 PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for @entity1 motion for primary @entity2 (EC). METHODS: Thirty-three @entity0 with EC sequentially underwent contrast-enhanced 3DCT, 4DCT, and @entity3 PET-CT thoracic simulation. The internal gross target volume (IGTV)10 was obtained by combining the GTV from ten phases of 4DCT. The GTVs based on PET/CT images were defined by setting of different standardized uptake value thresholds and visual contouring. The difference in volume ratio, conformity index (CI), and @entity4 ( @entity4 ) between IGTV10 and GTVPET was compared. RESULTS: The images from 20 @entity0 were suitable for further analysis. The optimal volume ratio of 0.95  0.32, 1.06  0.50, 1.07  0.49 was at standardized uptake value (SUV)2.5, SUV20%, or manual contouring. The mean CIs were from 0.33 to 0.54. The best CIs were at SUV2.0 (0.51  0.11), SUV2.5 (0.53  0.13), SUV20% (0.53  0.12), and manual contouring (0.54  0.14). The mean DIs of GTVPET in IGTV10 were from 0.60 to 0.90, and the mean DIs of IGTV10 in GTVPET ranged from 0.35 to 0.78. A negative correlation was found between the mean CI and different SUV (P=0.000). CONCLUSION: None of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV10. Further evaluation and optimization of PET as a tool for target identification are required.

title: A comparative study of target volumes based on XXXX PET-CT and ten phases of 4DCT for primary @entity2 .

answer: @entity3


abstract: The purpose of this study was to analyze changes in the T-helper cell 1/T-helper cell 2 ( @entity2 /Th2) balance of peripheral T-helper cells after autologous peripheral blood stem cell transplantation (auto-PBSCT) for @entity4 ( @entity4 ) and to evaluate the effects of chemotherapy and @entity3 ( @entity3 ) on the @entity2 /Th2 balance. A series of peripheral blood samples from four @entity0 with @entity4 were collected before peripheral blood stem cell harvest and after auto-PBSCT. Using flow cytometry, @entity2 and Th2 cells were identified by their intracellular cytokines: @entity1 + and @entity5 +/ @entity1 -, respectively. The @entity2 /Th2 balance was estimated as the ratio of IL4-/ @entity1 + cells to @entity5 +/ @entity1 - cells. Although the @entity2 /Th2 balance decreased initially, it increased markedly 28 days after the cessation of @entity3 , following auto-PBSCT, in parallel with an increase in lymphocytes. This increase was mainly due to an increase in the proportion of @entity2 cells. The @entity2 /Th2 balance did not change appreciably before PBSC harvest. Serum @entity1 increased after auto-PBSCT in three @entity0 . These preliminary data demonstrate that, after auto-PBSCT for @entity4 , the @entity2 /Th2 balance decreases initially and then increases after 1 month to levels above pretreatment levels and that the effects of chemotherapy and @entity3 on the @entity2 /Th2 balance are negligible before PBSC harvest. Further evaluation of the @entity2 /Th2 balance after allogeneic PBSCT at the single-cell level should be undertaken using this method.

title: Changes in the T-helper cell 1/T-helper cell 2 balance of peripheral T-helper cells after autologous peripheral blood stem cell transplantation for XXXX .

answer: @entity4


abstract: An in vitro glucuronidation assay was used to optimize a series of @entity3 -containing @entity1 inhibitors for metabolic stability. The glucuronidation of these compounds in @entity2 microsomes followed Michaelis-Menten kinetics allowing calculation of V(max) and K(M). The V(max) values ranged from 0.02 to 7.9 nmol/min/mg microsomal protein, a 400-fold difference, whereas K(M) ranged from 204 to 2500 microM, only a 12-fold difference. In vitro intrinsic clearance values (CL(int) were calculated for 18 compounds tested in the kinetic assay and compared with the in vivo plasma clearance (CL(p)) calculated from intravenous studies done in @entity2 . These initial results suggested a relationship between the in vitro CL(int) and in vivo duration as defined by CL(p). A more rapid in vitro assay was developed in a 96-well format using a single concentration of substrate (100 microM) from which a glucuronidation rate was calculated. The results from this assay for 40 compounds correlated with in vivo plasma clearance (r = 0.57). This more efficient assay was used to test more than 100 compounds and develop structure-metabolism relationships based on metabolic stability and improved duration. The culmination of this effort contributed to the discovery of @entity4 , a @entity1 inhibitor with in vivo duration in monkey improved 40-fold over thefirst generation inhibitor. Further studies performed in @entity0 liver microsomes demonstrated a similar trend that was corroborated by the 8-fold increase in duration after oral dosing in @entity0 observed with @entity4 .

title: Improving the in vivo duration of XXXX inhibitors: application of an in vitro glucuronosyltransferase assay.

answer: @entity1


abstract: Repeated @entity2 , because it challenges already activated cells, may elicit a reaction that differs from that provoked by a single injury. We compared the response of @entity0 aorta to single and @entity1 and tested the inhibitory effect of heparin in both situations. For repeated injury, the first and second lesions were induced 3 weeks apart. Two weeks after repeated injury, the @entity5 that existed from the first lesion had expanded, with significant increases in intima-media wet weight and its DNA and @entity4 content and in the intima-to-media (I/M) thickness ratio. Two days after repeated injury, the expression of @entity3 ( @entity3 ) was enhanced in both the media and the intima, indicating that cells from both layers are involved in the aortic response to a second lesion. As established previously, treatment with heparin (continuous intravenous administration, 50 IU/kg.h-1) almost totally suppressed the response to single injury. However, heparin only attenuated the response to repeated injury, with a partial decrease in intima-media wet weight and its DNA and @entity4 content and in I/M thickness ratio. @entity3 labeling showed that heparin inhibited the proliferative activity in medial cells much more strongly than in intimal cells. In conclusion, repeated @entity1 elicits a reaction of both the media and preexisting @entity5 . In this mixed response, neointimal smooth muscle cells are less sensitive than medial cells to inhibition by heparin, which results in a weakened effect of the drug on the fibromuscular reaction.

title: @entity1 of @entity0 aorta. A model of XXXX with attenuated inhibition by heparin.

answer: @entity5


abstract: Deuteration provides a novel means for studying metabolism in biological organisms and avoids the use of radioisotopes. Ingestion of @entity2 enriched drinking water causes @entity4 to be metabolically incorporated into molecules within tissues. The incorporation of @entity4 into various chemical functional groups then can be monitored via infrared spectroscopy. The excellent spatial resolution that can be achieved with Fourier transform infrared (FT-IR) microspectrometers allows collection of infrared spectra from select microscopic regions of tissue specimens. Thus, combining deuteration together with FT-IR microspectroscopy enables analysis of metabolic activities by probing subregions within the microscopic field. In the present study, adult @entity0 were given drinking water containing 30% or 40% @entity2 for 5 1/2 weeks. Frozen sections were prepared from the cerebellum, and infrared spectra were collected from the molecular layer, granule cell layer and white matter with FT-IR microspectrometers, using both conventional and synchrotron sources. The CD:CH and @entity5 , @entity3 :NH, @entity1 ratios were highest in the molecular layer and lowest in the white matter. The high ratios in the molecular layer are consistent with the active synthesis and recycling at synapses, which are abundant structures in this layer. The low levels in the white matter are consistent with radioactive measures that found slow turnovers of proteins and lipids in myelin, which is the main constituent of white matter. In addition to describing the metabolic incorporation of @entity4 , a graphic description of the distribution of chemical functional groups in the various layers of the cerebellum is presented. In summary, this study demonstrates that FT-IR microspectroscopy in conjunction with administration of @entity2 in drinking water can be used to reveal relative metabolic activities in various layers of the cerebellum. We predict that metabolic activities in other tissues and tissues in different states, e.g., disease states, can be analyzed in a similar manner.

title: FT-IR microspectroscopic detection of metabolically deuterated compounds in the XXXX cerebellum: a novel approach for the study of brain metabolism.

answer: @entity0


abstract: OBJECTIVE: Rurally situated African Americans suffer from stress and drug-related health disparities. Unfortunately, research on potential mechanisms that underlie this public health problem have received limited focus in the scientific literature. This study investigated the effects of perceived stress, @entity1 consumption, and genotype on the @entity4 . METHODS: A rural sample of African American emerging adults (n = 84) completed a battery of assessments and provided six samples of salivary @entity2 at wakeup, 30 min post wakeup, 90 min post wakeup, 3:00 PM, 3:30 PM, and 4:30 PM. RESULTS: @entity0 with a TT genotype of the @entity5 ( @entity6 ) gene tended to produce the most basal @entity2 throughout the day while @entity0 with a CC genotype produced the least amount. Increased levels of perceived stress or @entity1 consumption were associated with a blunted @entity2 awakening response (CAR). Moreover, the CAR was obliterated for @entity0 who reported both higher stress and @entity1 consumption. CONCLUSION: Perceived stress and @entity1 consumption had a deleterious effect on the @entity4 . Furthermore, genotype predicted level of @entity2 production throughout the day. These findings support the need to further investigate the relationship between @entity3 , drug-use vulnerability, and associated health disparities that affect this community.

title: The relationship between XXXX consumption, perceived stress, and @entity5 genotype on the @entity4 in rural African Americans.

answer: @entity1


abstract: The importance of @entity5 ( @entity5 ) due to @entity1 is recognized in the treatment of @entity2 . We have investigated the physiological effects of plasmin generation in experimental acute @entity5 using @entity0 deficient in plasminogen ( @entity7 -/-) or @entity8 ( @entity8 -/-). @entity5 was induced by continuous induction of @entity6 in the left jugular vein by endothelial injury due to photochemical reaction. The mortality of wild-type @entity0 was 68.8% at 2 h after the initiation of @entity1 and it was significantly reduced in @entity8 -/- @entity0 (41.7%). In contrast, @entity7 -/- @entity0 did not survive. Histological evidence of @entity4 in the lung was obtained in all @entity0 . However, whereas a strict @entity4 was observed in @entity7 -/- @entity0 , only a few thrombi were detected in the lungs of @entity8 -/- @entity0 . Plasma fibrinogen levels measured in @entity0 were not different. When @entity8 was infused in @entity8 -/- @entity0 , the mortality was indistinguishable from wild-type @entity0 . Tissue-type plasminogen activator ( @entity3 ) did not reduce the mortality due to acute @entity5 in wild-type @entity0 . However, in @entity8 -/- @entity0 , @entity3 (0.52 mg x kg-1) significantly decreased the mortality compared with that of @entity8 -/- @entity0 without @entity3 . The bleeding time was not significantly prolonged in either type of @entity0 treated with @entity3 . The lack of plasminogen increases the mortality due to acute @entity5 while a lack of @entity8 decreases the mortality rate, which can be further reduced by @entity3 administration. Therefore, the combination of inhibition of @entity8 with thrombolytic therapy could be beneficial in the treatment of acute @entity5 .

title: @entity8 plays a significant role in XXXX .

answer: @entity5


abstract: @entity0 produces a low basal level of @entity4 (0.002 to 0.004 IU/mg of protein when @entity1 is used as substrate). The @entity4 specific activity can be increased several hundredfold by growing the bacteria in the presence of @entity2 antibiotics. This induction was studied in @entity0 1822s. The single-cell resistance to @entity1 was 750 mug/ml. In liquid culture all concentrations of @entity1 tested (25 to 2,000 mug/ml) affected the bacteria similarly: @entity4 formation was induced, the cells became cholate sensitive, growth rate decreased, filaments were formed, and @entity4 was excreted. The effect appeared earlier the higher the concentration of the antibiotic. Most of the effects obtained are concerned with the functioning of the outer membrane. The excretion of @entity4 seems to be due to an opening of the periplasmic volume rather than to lysis of the cells. @entity3 gave the same effects as @entity1 at the same concentrations; the 10-fold lower resistance to @entity3 than to @entity1 can be explained by the inability of the inducible @entity4 to hydrolyze @entity3 . The induced @entity4 was first cell bound and to a great extent located in the periplasmic volume, but later it was excreted into the medium. This extracellular activity was responsible for the detoxification of the medium. This is analogous to the behavior of gram-positive bacteria rather than to that of Enterobacteriaceae.

title: Effects of sublethal concentrations of @entity1 on XXXX .

answer: @entity0


abstract: OBJECTIVES: This study aims to describe time trends of epidemiologic characteristics and imaging features over 14 years among histologically confirmed @entity5 ( @entity3 ) in China and to discuss the possible reasons for these changes. MATERIALS AND METHODS: Data of 21,113 pathologically confirmed @entity1 @entity0 from January 1999 to December 2012 were analyzed retrospectively. Preoperative high-resolution computer tomography (HRCT) images were available and reviewed in 5,439 lung @entity3 @entity0 since 2005. Time trends of the @entity3 proportion of @entity1 cases, gender distribution, age at diagnosis, the proportion of early-stage @entity3 and imaging features were investigated. RESULTS: The proportion of @entity3 increased during the 14 years (P = 0.000). The ratio of female to male @entity3 cases was higher than both @entity4 ( @entity4 ) and @entity1 cases (P = 0.000). The median age at diagnosis of @entity3 @entity0 was younger than that of both @entity2 during the 14 years (P = 0.000). The proportion of age group 45-59 years @entity1 cases (P = 0.000). When stratified by @entity1 histopathologic subtypes, this trend was also observed in @entity3 (P = 0.001) and @entity4 (P = 0.007). The proportion of early-stage cases of @entity3 increased from 2008 to 2012 (P < 0.001). The proportion of subsolid nodules (SSN) in @entity3 increased (P = 0.001) from 2005 to 2012. CONCLUSION: The data suggests that the proportion of @entity3 increased from 1999 to 2012 especially in middle-aged, female @entity0 ; early-stage @entity3 and SSN on HRCT images gradually increased, which may have been caused by a change in smoking habits and increased application of HRCT.

title: Time Trends in Epidemiologic Characteristics and Imaging Features of XXXX : A Population Study of 21,113 Cases in China.

answer: @entity5


abstract: UNASSIGNED: Relapse of @entity2 ( @entity2 ) is deemed invariably fatal yet increasing numbers of @entity2 @entity0 achieve a second complete/very good partial remission (CR/VGPR), hence the urgency to find a successful consolidative therapy. Identifying efficacy in @entity0 without assessable disease, however, is problematic. We report the first study providing outcome data for this group of @entity0 with poor prognosis. To prevent another relapse, @entity2 @entity0 in second or later CR/VGPR received the anti-GD2 murine antibody 3F8 plus @entity4 plus @entity6 in a Phase II trial. Upon meeting the target aim for progression-free survival (PFS) in the initial cohort of 33 @entity0 , the trial was amended to allow @entity0 who developed human anti-mouse antibody (HAMA) to receive rituximab to ablate HAMA with or without low-dose maintenance chemotherapy until immunotherapy could resume. For the total of 101 study @entity0 , 5-year PFS and @entity3 ( @entity3 ) rates were 33%    5% and 48%    5%, respectively. Among the 33 long-term progression-free survivors, 19 had @entity5 amplification, 19 had previously received anti-GD2 immunotherapy plus @entity6 (as first-line therapy), and 15 never received maintenance chemotherapy. In a multivariate analysis of prognostic factors, only absence of minimal @entity1 in bone marrow after 2 cycles of immunotherapy and before initiation of @entity6 or anti-HAMA therapy was significantly favorable for both PFS and @entity3 . Therefore, long-term PFS is possible for @entity2 @entity0 who achieve at least a second CR/VGPR and receive consolidation that includes anti-GD2 immunotherapy plus @entity6 , even if the @entity0 received these biological treatments before relapse. Results from this prospective study will aid in the development of future Phase II studies for this growing ultra high-risk @entity0 population.

title: Prolonged progression-free survival after consolidating second or later remissions of XXXX with Anti-GD2 immunotherapy and @entity6 : a prospective Phase II study.

answer: @entity2


abstract: @entity2 ( @entity2 ) is a very prevalent disease and @entity1 ( @entity1 ) usually account for the @entity2 . However, the pathogenesis of @entity1 is complicated and difficult to elucidate. Alternative splicing is a sophisticated regulatory process which greatly increases cellular complexity and phenotypic diversity of eukaryotic organisms. In addition, the cartilage endplate-derived stem cells have been discovered and identified by our research group. In this paper, we continue to investigate gene expression profiling and alternative splicing events during chondrogenic differentiation of cartilage endplate-derived stem cells. We adopted Affymetrix @entity0 Transcriptome Array 2.0 (HTA 2.0) to compare the transcriptional and splicing changes between the control and differentiated samples. RT-PCR and quantitative PCR are used to validate the microarray results. The GO and KEGG pathway analysis was also performed. After bioinformatics analysis of the data, we detected 1953 differentially expressed genes. In terms of alternative splicing, the Splicing Index algorithm was used to select alternatively spliced genes. We detected 4411 alternatively spliced genes. GO and KEGG pathway analysis also revealed several functionally involved biological processes and signaling pathways. To our knowledge, this is the first study to investigate the alternative splicing mechanisms in chondrogenic differentiation of stem cells on a genome-wide scale.

title: Global Gene Expression Profiling and Alternative Splicing Events during the Chondrogenic Differentiation of XXXX Cartilage Endplate-Derived Stem Cells.

answer: @entity0


abstract: UNASSIGNED: Distinguishing primary cutaneous @entity5 from @entity5 of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old @entity0 presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. @entity2 cells had a histiocytoid appearance and displayed mild pleomorphism. The @entity2 was discohesive and had areas with a single file pattern. Signet ring cells were also present. Cells were reactive with @entity12 , @entity9 , @entity10 , @entity15 , @entity11 and @entity7 . Additional studies were negative, including @entity16 , @entity14 , E-cadherin, mammaglobin, @entity4 receptor and @entity6 receptor. Thorough clinical and radiologic evaluation failed to identify an occult primary extracutaneous @entity2 ; however, regional @entity8 , @entity3 and multiple subcentimeter liver @entity13 were noted. Considering the clinical and histopathologic features, the diagnosis of primary cutaneous @entity5 with distant @entity1 was favored.

title: Primary cutaneous XXXX with distant @entity1 .

answer: @entity5


abstract: BACKGROUND: The database of a major regional health insurer was employed to identify the number and frequency of covered @entity0 with @entity2 ( @entity2 ). We then examined the characteristics of their care as defined, in part, by the frequency of physician visits and specialty referral, the characteristics of laboratory testing and total costs as indices of the quality of care of the subject population. METHODS: This retrospective, cross-sectional study analyzed insurance claims, laboratory results and medication prescription data. @entity0 with two estimated glomerular filtration rate readings below 60  ml/ @entity3 .73  m(2) (n   =   20,388) were identified and classified by @entity2 stage. RESULTS: The prevalence of @entity2 stages 3a and above was 12 %. Vascular comorbidities were common with prevalence increasing steadily from stage 3a through stage 5. Only 55.6 % of stage 4 @entity2 @entity0 had claims for nephrology visits within one year of their index date. Fifty-nine percent of @entity0 had claims for renin-angiotensin system (RAS) blockers. Twenty-five percent of @entity0 in stage 3a @entity2 filled a prescription for non-steroidal anti-inflammatory drugs. Fifty-two percent of @entity0 who developed @entity1 received their first dialysis treatment as inpatients. CONCLUSIONS: The pattern of medical practice observed highlights apparent deficiencies in the care of @entity2 @entity0 including inappropriate medication use, delayed nephrology referral, and a lack of preparation for dialysis. This study shows the potential value of using large @entity0 databases available through insurers to assess and likely improve regional @entity2 care.

title: An observational study of the quality of care for XXXX : a Buffalo and Albany, New York metropolitan area study.

answer: @entity2


abstract: UNASSIGNED: @entity3 can be classified into three subgroups according to pattern of @entity2 infiltration into the surrounding tissue: @entity4 (expanding growth and a distinct border with the surrounding tissue), INFc (infiltrating growth and an indistinct border with the surrounding tissue), and INFb (in-between a and c). How the @entity2 infiltration pattern (INF) relates to prognosis and type of recurrence in advanced @entity3 has not been sufficiently explored. We examined 805 consecutive advanced @entity3 @entity0 who underwent curative gastrectomy at our institution between 1980 and 2005. Poor differentiation, serosal invasion, and lymph node @entity1 were significantly more frequent in @entity0 with @entity2 than in those with @entity4 /b @entity2 . For @entity0 with a T2 or T3 @entity2 , there was no significant difference in prognosis between those with @entity4 /b and with INFc. However, for @entity0 with a T4a or T4b @entity2 , the prognosis of those with INFc was significantly worse than that of those with @entity4 /b. In multivariate analysis, INF was an independent prognostic indicator in T4a but not T2, T3, and T4b. Furthermore, the prognosis of T4 @entity0 with @entity2 was significantly worse than that of those with @entity4 /b, especially in node-negative but not in node-positive cases. In @entity0 with a T4a or T4b @entity2 , peritoneal recurrence was significantly more frequent for those with INFc than for those with @entity4 /b. Our data indicate that INF is useful to predict the prognosis and recurrence pattern in T4a node-negative @entity3 .

title: Tumor infiltration pattern into the surrounding tissue has prognostic significance in advanced XXXX .

answer: @entity3


abstract: UNASSIGNED: Recent years have seen rising concerns over increasing antibiotic resistance of the @entity3 -causing bacterium, @entity4 . This is especially true for third-generation @entity2 , which are currently recommended for the treatment of such infections. Therefore, susceptibility to these antibiotics should be monitored internationally to the greatest extent possible. The susceptibility of @entity4 strains to @entity1 and @entity0 , as well as production of beta-lactamase by the Cefinase test was determined. Moreover, the presence and type of penicillinase plasmids were determined by PCR. All strains were susceptible to @entity1 , the minimal inhibitory concentration (MIC) values ranged from 0.002 to 0.125  mg/L; MIC50 was =0.016  mg/L and MIC90 was =0.064  mg/L. As much as 7.7  % of the strains demonstrated @entity1 MIC of 0.125  mg/L. For @entity0 , the MICs ranged from 0.064 to 32  mg/L; MIC50 was =0.5  mg/L and MIC90 was =4  mg/L. It was shown that only 1.5  % of the strains were sensitive to @entity0 according to The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Among the @entity0 -resistant strains, six (30.0  %) produced penicillinase. The MICs of @entity0 were substantially higher for penicillinase-producing than for @entity0 -resistant, penicillinase-negative strains. MICs of @entity1 for penicillinase-producing strains were low (0.002-0.016  mg/L). Three of the penicillinase-producing strains possessed plasmids of African type (50  %) and three Toronto/Rio type (50  %). An increase of the proportion of beta-lactamase-positive strains in the last years as well as emergence of strains with elevated MIC of @entity1 indicate a need to constantly monitor @entity4 strains for their susceptibility to @entity5 antibiotics, as well as for their ability to produce beta-lactamases.

title: Susceptibility to XXXX and occurrence of penicillinase plasmids in @entity4 strains isolated in Poland in 2012-2013.

answer: @entity1


abstract: To determine the origin of conduction disturbances commonly seen in the ECG after correction of Fallot's tetralogy, 36 @entity0 underwent electrophysiologic studies; these included endocardial recordings of right ventricular (RV) and left ventricular (LV) apical activation and His-bundle recordings. The surface ECG showed a pattern of complete @entity3 ( @entity3 ) in 22, and @entity3 with @entity4 ( @entity4 )--so-called @entity2 --in nine; the remaining five had @entity3 , @entity4 , and a long PR interval, often considered as indicating @entity2 . Eight of 22 @entity0 with @entity3 and normal axis had delayed RV apical activation (36%), indicating a proximal lesion. Of nine @entity0 with @entity3 and @entity4 , four only had delayed RV apical activation (44%); in the other five, therefore, the @entity3 pattern was due to a peripheral lesion (ventriculotomy); they cannot be considered as having true @entity2 . LV activation was not delayed in any case. In five cases, the surface ECG suggested @entity2 (long PR in the presence of @entity3 and @entity4 ). His-bundle recordings showed the HV interval to be prolonged in only two cases, at the upper limit of normal in two, and short in one. The AH interval was prolonged in all and was mainly responsible for the long PR interval. Thus, the surface ECG is not a reliable tool for making a diagnosis of true @entity2 and @entity1 after correction of Fallot's tetralogy. This may explain controversies existing about the prognosis of @entity2 .

title: Intraventricular conduction disturbances after correction of tetralogy of Fallot: can bifascicular and XXXX be diagnosed from the surface ECG?

answer: @entity2


abstract: OBJECTIVE: To validate the ability of the American College of Rheumatology (ACR) clinical classification criteria and the ACR clinical plus radiographic classification criteria for @entity3 of the knee to predict articular @entity1 . METHODS: Ninety subjects with @entity4 ( @entity3 ) who were enrolled in a prospective study determining the therapeutic efficacy of arthroscopic irrigation were characterized as to whether they fulfilled the ACR clinical classification criteria or the ACR clinical plus radiographic classification criteria. Ten @entity2 ( @entity2 ) @entity0 were included as controls. @entity1 was defined using the ACR/Knee Arthroscopy @entity3 Scale (ACR/KAOS) system, which is a validated outcome instrument for knee @entity3 based on arthroscopic visualization. Mean values of the damage scores in each group were calculated and compared by t-test to determine statistical significance between the 3 groups. RESULTS: The mean ACR/KAOS score for the 10 @entity2 @entity0 was 1.8 [SD 1.22; range 0 to 4]. Of the 90 @entity3 @entity0 who underwent arthroscopy, only 73 @entity0 had sufficient videotape to make an accurate assessment by the blinded assessor. The mean ACR/KAOS score for the 6 @entity3 @entity0 who fulfilled only the ACR clinical classification was 17.4 [SD 11.3; range 5 to 34.3] and the mean ACR/KAOS score for the 67 @entity0 who fulfilled the ACR clinical plus radiographic classification criteria was 42.0 [SD 29.1; range 5.1 to 118.4]. These differences were statistically significant ( @entity2 versus @entity3 clinical P=0.02; @entity2 versus @entity3 clinical+radiographic P<or=0.01). Nonparametric multivariate analysis did not reveal significant correlations between ACR/KAOS scores and WOMAC global scores (r=0.11, P=0.39), @entity0 VAS (r=0.29, P=0.022), and age (r=0.29, P=0.08). CONCLUSIONS: The ACR clinical and clinical plus radiographic criteria for @entity3 of the knee accurately predict @entity1 as assessed by arthroscopy. Furthermore, the ACR clinical classification criteria identify @entity3 @entity0 with @entity1 before any radiographic change, while the ACR clinical plus radiographic classification criteria identify @entity3 @entity0 with more severe @entity1 . RELEVANCE: The ACR classification criteria correlates well with articular @entity1 in @entity0 with @entity3 .

title: Validation of American College of Rheumatology classification criteria for @entity4 using arthroscopically defined XXXX scores.

answer: @entity1


abstract: AIM: In this study, it was aimed to investigate which method was superior by applying selective head cooling or whole body cooling therapy in newborns diagnosed with moderate or severe @entity2 ischemic @entity1 . MATERIALS AND METHOD: Newborns above the 35th gestational age diagnosed with moderate or severe @entity2 ischemic @entity1 were included in the study and selective head cooling or whole body cooling therapy was performed randomly. The newborns who were treated by both methods were compared in terms of adverse effects in the early stage and in terms of short-term results. Ethics committee approval was obtained for the study (06.01.2010/35). RESULTS: Fifty three babies diagnosed with @entity2 ischemic @entity1 were studied. Selective head cooling was applied to 17 babies and whole body cooling was applied to 12 babies. There was no significant difference in terms of adverse effects related to cooling therapy between the two groups. When the short-term results were examined, it was found that the hospitalization time was 34 (7-65) days in the selective head cooling group and 18 (7-57) days in the whole body cooling group and there was no significant difference between the two groups (p=0.097). Four @entity0 in the selective head cooling group and two @entity0 in the whole body cooling group were discharged with tracheostomy because of the need for prolonged mechanical ventilation and there was no difference between the groups in terms of discharge with tracheostomy (p=0.528). Five @entity0 in the selective head cooling group and three @entity0 in the whole body cooling group were discharged with a @entity3 because they could not be fed orally and there was no difference between the groups in terms of discharge with a @entity3 (p=0.586). One @entity0 who was applied selective head cooling and one @entity0 who was applied whole body cooling died during hospitalization and there was no difference between the groups in terms of mortality (p=0.665). CONCLUSIONS: There is no difference between the methods of selective head cooling and whole body cooling in terms of adverse effects and short-term results.

title: Comparison of selective head cooling therapy and whole body cooling therapy in newborns with @entity2 ischemic XXXX : short term results.

answer: @entity1


abstract: BACKGROUND: Pemphigus is a group of autoimmune blistering diseases of which the major forms are @entity3 ( @entity3 ) and vulgaris ( @entity2 ). In Brazil, @entity3 occurs in an endemic form also known as fogo selvagem. The main autoantibody in @entity3 is against @entity4 ( @entity4 ), while in @entity2 the main antibody is anti- @entity5 ( @entity5 ), but often anti- @entity4 is also present. The aim of the present study was to analyze the levels of anti- @entity4 and antiDSG3 autoantibodies in Brazilian @entity3 and @entity2 @entity0 , considering different stages of the disease for @entity3 @entity0 and comparing these levels to those of healthy individuals living in and outside the endemic regions. METHODS: Levels of anti- @entity4 and anti- @entity5 were measured in the sera of Brazilian @entity3 (n = 68) and @entity2 (n = 20) @entity0 as well as in clinically healthy (control) individuals (n = 48) by Enzyme Linked Immunosorbent Assay (ELISA). Comparisons were made using Kruskal-Wallis and Mann-Whitney tests. RESULTS: As expected, anti- @entity4 was more prevalent among @entity3 @entity0 (84% against 43% in @entity2 ), while antiDSG3 was more prevalent in @entity2 @entity0 (50% against 4% in @entity3 ). Levels of anti- @entity4 in @entity3 @entity0 in remission differed from those in @entity0 undergoing active disease (p = 0.003), and @entity0 in long-term remission (more than two years without presenting @entity1 ) were similar to control individuals living in the endemic region and surrounding area (p = 0.09). Moreover, @entity0 with a more severe form of the disease had higher levels of anti- @entity4 (at least 134 U/mL, mean of 233 U/mL) than @entity0 with a less severe form (fewer lesions) (mean of 193 U/mL, including two negative individuals). CONCLUSIONS: Despite the importance of these antibodies for diagnosis and management purposes, their presence in a healthy individual and in @entity0 under remission indicates that caution should be taken when using anti-DSG for diagnosis, especially in endemic areas.

title: Anti- @entity4 and 3 Autoantibody Levels in Endemic Pemphigus Foliaceus and XXXX from Brazil.

answer: @entity3


abstract: UNASSIGNED: 57 Background: Histoscanning is a novel ultrasound-based software programme, which uses back-scattered ultrasound, to detect and @entity3 . It is not clear to date which additive information histoscanning will deliver terms of additive information to ultrasound guided transrectal biopsy as research is scarce.Therefore we aimed to analyze our data on repeat biopsy with histoscanning prior to intervention. METHODS: From Sept. 2009 till present, 61 @entity0 , mean age 62 yrs, that were scheduled for repeat biopsy received Histoscanning prior to intervention. Acquired data were retrospectively processed with Histoscanning software version 2.2 and prostate was divided into a 6 grid pattern. Lesions >= 0,5ml were considered positive. Biopsies were taken according to Vienna normogram and processed by an experienced uropathologist. RESULTS: Mean number of biopsies prior to repeat was 2. Mean PSA at repeat biopsy was 7,135 ng/ml, mean prostate volume accounted for 45.5 ml. A total of 15/61 @entity0 were diagnosed with @entity1 (24,59%), Gleason Score (Gl.) of 6 n=10, n=2 Gl. 3+4=7, n=2 Gl. 4+4; n=2 Gl. 4+5=9 respectively. A total of 43/834=5.15% positive cores were obtained, averaging 0.7 per @entity0 . Mean Volume of Histoscanning lesions per scan: 1,48 ml; no statistical significance can be detected regarding the volume per sextant and a positive core. False positive rate was 90/366=24,6%; false negative rate was 19/366=5,2%. Overall sensitivity was 29,69%, specifity accounted for 73.3%. @entity5 was calculated at 8.16% and NPV at 92,88%. PSA had no influence on detection rate. CONCLUSIONS: In this highly seleted @entity0 cohort Histoscanning had no beneficial nor additive information on detecting @entity3 . Further research should has to be done regarding Histoscanning lesions with different histopathological features such as @entity4 and @entity2 .

title: Is histoscanning a valid tool to XXXX in repeat biopsy?

answer: @entity3


abstract: UNASSIGNED: Intrarenal hemodynamics depend on blood pressure (BP), heart rate (HR), and smoking. Although BP levels have been associated with kidney function, the effect of HR levels, BP, and HR variability on renal function are less well clarified. This cross-sectional study sought to determine the association of 24-hour BP and HR variability with kidney function in @entity2 @entity0 , stratified by smoking. The study comprised 9600 nondiabetic, never-treated @entity2 individuals without evident @entity1 examined from 1985 to 2014 (aged 53.3  13.4  years, 55.3% males). The 24-hour systolic BP (SBP) and HR variability were estimated via their coefficient of variation (CV =standard deviation*100/mean value) derived from ambulatory recording. The CV SBP-to-CV HR ratio (CV R) was used as a marker of the interplay between 24-hour SBP and HR variability. Renal function was estimated via 24-hour urine @entity3 clearance (CrCl), estimated glomerular filtration rate (eGFR), albumin-to- @entity3 ratio (ACR), and 24-hour urine a1 -microglobulin. After adjustment for age, sex, and smoking, CV SBP was  found to be weakly correlated to eGFR (r=-0.017, P=.1) and somewhat more strongly to CrCl, ACR, and a1 -microglobulin (r=-0.032, 0.072, and 0.065; P=.002, <.001 and <.001, respectively). CV HR was much better related to renal function, with stronger adjusted correlations to CrCl, eGFR, ACR, and a1 -microglobulin (r=0.185, 0.134, -0.306, -0.247; all P<.001, respectively). CV R also showed equally good adjusted correlations (r=-0.175, -0.125, 0.336, 0.262; all P<.001, respectively). Most adjusted correlations for CV HR and CV R were even better in smokers (r=0.213, 0.158, -0.332, -0.272 and -0.183, -0.118, 0.351, 0.275, respectively; all P<.001). CV HR and CV R emerge as better related to kidney function than CV SBP, especially in smokers. The correlation of CV HR and CV SBP to renal function is inverse to each other. ACR and a1 -microglobulin are better related to variability indices than CrCl and eGFR. However, causal relations cannot be proved.

title: Correlation of 24-Hour Blood Pressure and Heart Rate Variability to Renal Function Parameters in @entity2 XXXX . The Effect of Smoking.

answer: @entity0


abstract: @entity4 , mainly @entity2 , that are synthesized in source organs are transported to sink organs to support growth and development. Phloem loading of @entity2 is a crucial step that drives long-distance transport by elevating hydrostatic pressure in the phloem. Three phloem loading strategies have been identified, two active mechanisms, apoplastic loading via @entity2 transporters and symplastic polymer trapping, and one passive mechanism. The first two active loading mechanisms require metabolic energy, @entity3 is loaded into the phloem against a concentration gradient. The passive process, diffusion, involves equilibration of @entity2 and other metabolites between cells through plasmodesmata. Many higher plant species including @entity1 utilize the active loading mechanisms to increase @entity3 in the phloem to higher concentrations than that in mesophyll cells. In contrast, recent data revealed that a large number of plants, especially woody species, load @entity2 passively by maintaining a high concentration in mesophyll cells. However, it still remains to be determined how the worldwide important cereal crop, @entity0 , loads @entity2 into the phloem in source organs. Based on the literature and our results, we propose a potential strategy of phloem loading in @entity0 . Elucidation of the phloem loading mechanism should improve our understanding of @entity0 development and facilitate its manipulation towards the increase of crop productivity.

title: The mechanism of phloem loading in @entity0 ( XXXX ).

answer: @entity0