abstract: UNASSIGNED: @entity6 reductase (RR) has been reported to be associated with several types of @entity2 while the expression and role of RR in @entity4 ( @entity4 ) has not been investigated. Here, we first examined the expression level of three RR subunit proteins ( @entity8 , @entity10 , and @entity11 ) in @entity7 ( @entity7 ) and @entity3 ( @entity3 ) @entity0 samples by immunohistochemistry. The results showed that @entity8 was higher expressed in 95.2  % @entity2 tissues compared with their adjacent normal tissues in 146 @entity7 samples. The expression level of @entity8 was positively correlated with T stage, lymph node @entity1 (LNM), @entity1 ( @entity1 ), and TNM stage in @entity7 @entity0 . However, in 12 @entity3 samples, @entity8 expression was negatively expressed in six cases. To further determine the biological role of @entity8 in @entity4 , ectopic expression or siRNA-mediated knockdown of @entity8 were carried out in the high-differentiated @entity4 cell line @entity9 and the poor-differentiated @entity4 cell line SW579, respectively. In @entity9 and @entity0 cells, overexpression and siRNA knockdown of @entity8 demonstrated that @entity8 promoted DNA synthesis and proliferation in both cell lines as shown by EdU incorporation and cell viability assays. However, @entity8 enhanced cell migration and invasion in @entity9 cells but inhibited that in @entity0 cells as shown by wound healing and transwell assays. Moreover, we also found that @entity8 promoted @entity5 expression and reduced Akt phosphorylation in a RR-activity-independent manner in the low-differentiated @entity4 cells but not in the high-differentiated @entity4 cells. In contrast, @entity10 expression was higher expressed in both @entity7 and @entity3 @entity0 samples, consisting with its oncogenic role in other @entity2 . Therefore, we suggest that @entity8 promotes @entity4 proliferation as a component of RR but may play a different role in the invasion and @entity1 of differently differentiated @entity4 through a non-RR pathway, which could be meaningful to precision treatment of @entity4 with RR inhibitors.

title: @entity6 reductase large subunit M1 plays a different role in the invasion and @entity1 of @entity7 and XXXX .

answer: @entity3


abstract: The aim of this study was to evaluate the correlation between the changes of SUV(max) and of apparent diffusion coefficient (ADC) before and after neoadjuvant therapy, to enable us predict the therapy response, in @entity0 with locally advanced @entity1 (LARC). A total of 30 @entity0 with LARC who underwent CRT were recruited for our study. All the @entity0 underwent a whole body @entity4 -PET/CT scan and a pelvic MR examination including DW imaging for staging (PET/ @entity5 and RM1), and after the chemoradiation therapy (PET/ @entity8 , and RM2). Histopathologic analysis of rectal specimen, according to @entity1 regression grade (Mandard's criteria) was used as the standard reference. MR and PET-CT images were analyzed, and measurements of ADC values and SUV(max) were taken. Diagnostic performance for selection of complete responders ( @entity6 -2) and overall diagnostic accuracy for each item were calculated. After neoadjuvant therapy, all @entity0 were submitted to surgery. According to Mandard's criteria, 21 @entity1 showed complete ( @entity6 ) or subtotal regression ( @entity7 ) and were classified as responders; nine @entity1 were classified as non responders ( @entity9 , 4, and 5). In all the @entity0 , mean value of SUV(max) in PET/ @entity5 was higher than those in PET/ @entity8 (P  <  0.001), whereas mean ADC value was lower in RM1 than RM2 (P  <  0.001), with a significant percentage decrease of values after the treatment (P  <  0.005).The best predictors cut-off values for TRG response were SUV(max) of 4.4 and ADC of 1.28     10(3)  mm(2)/s with sensitivity, specificity accuracy, negative predictive value, and positive predictive values of 77.3%, 88.9%, 80.7%, 61.5%, and 94.4%, respectively. We conclude from the overall data of this study that the absolute values of SUV(max) and ADC of @entity2 after CRT were the best parameters to define the response to treatment, by differentiating @entity3 from viable @entity1 tissue.

title: Response to neoadjuvant therapy in locally advanced XXXX : assessment with diffusion-weighted MR imaging and 18FDG PET/CT.

answer: @entity1


abstract: The @entity2 of @entity5 are rare, @entity1 , differentiated in their morphologic and clinical appearances. They may manifest either as asymptomatic @entity3 , or with the potentially fatal complication of @entity4 . They can be large in @entity5 , act as @entity6 and may result in massive @entity8 . Multiple imaging modalities have been employed in the diagnosis, including ultrasonography (US), computed tomography (CT), radionuclide studies, angiography, magnetic resonance (MR) imaging. Generally the US, Doppler and CT appearances of @entity2 may be diagnostic. Biopsy in often needed for diagnosis, especially if classic signs and symptoms are lacking. The diagnostic possibilities and difficulties in three @entity0 are discussed. Different US images were present in all three cases, with atypical CT appearance in one. Doppler signals were lacking in two cases. Sonographic appearance of infantile @entity2 is variable, non-specific, but Doppler US is useful as a non-invasive method in the follow-up of @entity7 .

title: [Diagnosis of neonatal XXXX ].

answer: @entity3


abstract: PURPOSE: To investigate @entity2 heterogeneity in the recurrence of @entity3 demonstrated by polycomb group (PcG) proteins. METHODS: Tissue microarrays containing matched primary and recurrent @entity3 from the same @entity0 were constructed for detection of PcG protein expression. Survival analyses of clinicopathological parameters and expression of PcG proteins were performed on progression-free survival (PFS) and @entity4 ( @entity4 ) of @entity0 . Genetic and epigenetic heterogeneity was explored in aspects of gene copy number and microRNA (miRNA) profiling. RESULTS: PcG proteins were heterogeneously expressed in primary versus recurrent @entity2 (P<0.05). In univariate survival analysis of the @entity3 cohorts, a significant association of intensive expression of @entity5 and @entity6 in first-onset lymph node @entity1 with shortened PFS was demonstrated (P=0.010, P=0.019); and a significant association of intensive expression of @entity5 and @entity6 in recurrent @entity2 with shortened @entity4 was demonstrated (P=0.042, P=0.047). Importantly, @entity5 and @entity6 expression provided significant independent prognostic parameters in multivariate analyses (P<0.05). Gene amplification did not always coincide with PcG protein expression. Eight miRNAs were found to be downregulated in recurrent @entity2 , among which @entity8 might indirectly regulate the expression of @entity6 through transcription factor @entity7 . CONCLUSION: @entity2 heterogeneity exists in the recurrence of @entity3 , manifested by PcG protein expression and underlying genetic and epigenetic alterations. Intensive expression of @entity5 and @entity6 are predictors of earlier relapse and @entity4 , independent of grade and chemotherapy sensitivity. @entity6 and @entity8 have great potential to be new targets for treatment of recurrent @entity3 .

title: XXXX heterogeneity in the recurrence of @entity3 demonstrated by polycomb group proteins.

answer: @entity2


abstract: In 33 @entity0 with @entity2 ( @entity2 ), 27 with combined @entity3 ( @entity2 + @entity1 ) and 23 with chronic @entity1 ( @entity1 ) left ventricular angiographic muscle mass (LMMI) was determined before and after successful valve replacement. Preoperative age in the three groups was 51, 47 and 42 years (P less than 0.05 vs. @entity2 ) respectively; recatheterization was carried out 17, 20 and 21 months postoperatively (not significant). In all three groups angiographic mass decreased (P less than 0.001) following surgery: In @entity2 from 167 to 117, in @entity2 + @entity1 from 200 to 127 and in @entity1 from 192 to 142 g/m2. Left ventricular end-diastolic wall thickness decreased from 1.22 to 1.02 (P less than 0.001) in @entity2 and from 1.19 to 1.03 cm (P less than 0.001) in @entity2 + @entity1 . No change of wall thickness occurred in the @entity0 with @entity1 . Left ventricular ejection fraction (EF) increased from 61 to 68% (P less than 0.01) in @entity2 , from 58 to 68% (P less than 0.005) in @entity2 + @entity1 and from 52 to 59% (P less than 0.02) in @entity1 . The postoperative EF in the @entity0 with @entity1 was smaller (P less than 0.05) than in @entity2 , @entity2 + @entity1 and in controls (EF = 68%, n = 18). Postoperative normalization of LMMI (less than or equal to 120 g/M2) occurred in 22/33 (67%) @entity0 with @entity2 , in 14/27 (52%) with @entity2 + @entity1 and in 8/23 (35%) with @entity1 . The age of the @entity0 and the time interval between surgery and recatheterization had no influence on postoperative normalization or non-normalization of LMMI.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Regression of heart hypertrophy in XXXX with operated @entity3 ].

answer: @entity0


abstract: OBJECTIVE: To evaluate the outcomes and @entity3 of concurrent full-dose @entity2 and intensity-modulated radiation therapy (IMRT) for @entity0 with borderline resectable and locally advanced @entity4 after induction chemotherapy. MATERIALS AND METHODS: From 2009 to 2012, 32 @entity0 were treated with concurrent @entity2 and IMRT for borderline resectable or locally advanced @entity4 . All @entity0 received induction FOLFIRINOX or @entity2 -based chemotherapy before chemoradiation. The radiotherapy volume was limited to the @entity1 , and the median dose was 55 Gy in 25 fractions. @entity2 was administered weekly during radiotherapy on days 1, 8, 22, and 29 at a median weekly dose of 800 mg/m. RESULTS: Twenty-five @entity0 had locally advanced disease and 7 had borderline resectable disease. The median follow-up time was 14.6 months. The median progression-free and overall survival were 13.9 and 23.1 months, with a trend toward improved overall survival for @entity0 receiving induction FOLFIRINOX compared with @entity2 -based therapy. A radiographic complete or partial response was achieved in 13 @entity0 (41%), with 4 (13%) having complete radiographic responses. Surgical resection was performed in 10 @entity0 (31%)-6 @entity0 with locally advanced disease and 4 with borderline resectable disease. Grade 3/4 hematologic @entity3 during and up to 6 weeks after chemoradiation occurred in 12 @entity0 (38%); grade 3 nonhematologic @entity3 occurred in 7 @entity0 (22%), with no grade 4 or 5 @entity3 . All @entity0 completed their radiotherapy. CONCLUSIONS: Concurrent full-dose @entity2 and limited-field IMRT after induction chemotherapy for the treatment of borderline resectable and locally advanced @entity4 is promising with acceptable @entity3 rates.

title: Induction Chemotherapy Followed by Concurrent Full-dose @entity2 and Intensity-modulated Radiation Therapy for Borderline Resectable and Locally Advanced XXXX .

answer: @entity4


abstract: UNASSIGNED: The clinical significance of ineffective esophageal motility (IEM) together with @entity2 ( @entity2 ) has not been yet evaluated in the Chicago Classification v3.0. This study evaluated the adjunctive role of @entity2 in IEM and determined the criteria of abnormal @entity2 to maximize the utility of IEM. We analyzed 186 @entity0 showing IEM or normal esophageal motility (NEM), who underwent esophageal high-resolution impedance-manometry for esophageal symptoms. Two different criteria for abnormal @entity2 were applied to IEM subjects, resulting in 2 corresponding subgroups: IEM-A when distal contractile integral (DCI) ratio between an average wet swallows and @entity2 contraction was <1 and IEM-B when @entity2 contraction DCI was <450mm Hg-s-cm. One IEM subject inadequately performed @entity2 . Among the remaining 52 IEM subjects, 18 (34.6%) were classified into IEM-A and 23 (44.2%) into IEM-B. IEM subjects showed less complete bolus transit (median 0.0%, interquartile range 0.0-20.0% vs 60.0%, 30.0-80.0; P<0.001) resulting in higher impaired bolus transit than NEM subjects (98.1% vs 66.9%, P=0.001). IEM-B subjects showed additionally higher pathologic bolus exposure than NEM subjects (55.6% vs 29.3%, P=0.001), whereas IEM-A subjects could not. Although IEM-B subjects had the highest prevalence of @entity1 among the subjects groups, it did not reach statistical significance. In conclusion, IEM @entity0 with abnormal @entity2 contraction have an increased risk of prolonged bolus clearance, poor bolus transit, and pathologic bolus exposure. IEM @entity0 need to be assessed concerning whether @entity2 contraction DCI is <450mm Hg-s-cm to segregate clinically relevant @entity0 .

title: Multiple Rapid Swallow Maneuver Enhances the Clinical Utility of High-Resolution Manometry in XXXX Showing Ineffective Esophageal Motility.

answer: @entity0


abstract: BACKGROUND CONTEXT: Recent advances in image guidance and stereotactic body radiotherapy (SBRT) have resulted in unprecedented local control for spinal metastases of all histologies. However, little is known about early imaging biomarkers of local control. PURPOSE: This study aimed to identify early magnetic resonance imaging (MRI) biomarkers to predict local control after SBRT for @entity0 with @entity3 spine metastases. STUDY DESIGN/SETTING: This study used a retrospective case series at a large tertiary @entity1 center. @entity0 SAMPLE: From 2011 to 2014, 9 consecutive @entity0 with 12 metastatic @entity2 to the spine were treated with SBRT and underwent evaluation with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) both pre- and post-SBRT. OUTCOME MEASURE: Changes in perfusion metrics, including the wash-in rate constant (Ktrans), plasma volume (Vp), composite multiparametric magnetic resonance imaging (mpMRI) score, bi-dimensional @entity1 size, and a graded response assessment were performed and correlated to local control. METHODS: All measurements were independent and blinded by two neuroradiologists. R(2) statistics were performed to document correlation, and two-tailed t tests were used to compare groups. p<.05 was deemed statistically significant. RESULTS: The median time from SBRT until posttreatment MRI was 57 days. Local failure developed in one lesion (8.3%) 10 months after SBRT. The Vp mean, Ktrans mean, Vp max, and Ktrans max were significantly decreased post-SBRT as compared with pre-SBRT (58.7%, 63.2%, 59.0%, and 55.2%; all p-values <.05). Bi-dimensional @entity1 measurements demonstrated an average increase in size across the cohort, and 50%, 25%, and 25% of the treated lesions demonstrated features of "worsening," "no change," or "improvement," respectively, by both radiologists' graded impressions. There was good inter-reader reliability for both size and subjective disease response scores(R(2)=0.84). The mpMRI score had 100% accuracy in predicting local control at time of last follow-up. There was no apparent correlation with size changes compared with the mpMRI score change post-SBRT (R(2)=0.026). CONCLUSIONS: We report the first analysis on the utility of DCE-MRI for metastatic @entity3 spine metastases treated with SBRT. We demonstrate that early assessment at 2 months post-SBRT using size and subjective neuroradiology impressions is insufficient to judge ultimate disease progression, and that a combination of perfusion parameters provides excellent correlation to local control.

title: Early magnetic resonance imaging biomarkers to predict local control after high dose stereotactic body radiotherapy for @entity0 with XXXX spine metastases.

answer: @entity3


abstract: PURPOSE: The physiological responses of the pulmonary vasculature and airway to various vasoconstrictors were studied using isolated perfused lungs and pulmonary arteries, but these responses were not systematically studied in in vivo @entity0 . We determined these responses and modulating effects of systemic circulation in anesthetized @entity0 . METHODS: We measured directly pulmonary arterial pressure (PAP), left atrial pressure (LAP), aortic blood flow, and airway pressure (AWP) to determine pulmonary vascular resistance (PVR), following injections of @entity2 ( @entity2 ), @entity3 ( @entity3 ), @entity4 , @entity6 and @entity5 mimetic @entity7 in anesthetized SD @entity0 . RESULTS: @entity2 , @entity6 and @entity4 at high doses caused strong systemic vasoconstriction and left heart overload, resulting in a transient increase in LAP and @entity1 , which consequently decreased PVR. Nonetheless, prior to LAP elevation, PVR was slightly but significantly increased by @entity2 and @entity6 . In contrast, @entity3 and @entity7 substantially increased PVR in the absence of LAP elevation, while @entity4 did not increase PVR. In separate experiments, PAP and AWP increased when LAP was forcedly elevated. AWP was increased by @entity7 through bronchoconstriction and by the other agents through increased LAP-induced @entity1 . CONCLUSION: Airway constriction is induced by @entity7 , and pulmonary vasoconstriction is induced strongly by @entity7 and @entity3 , and weakly by @entity2 and @entity6 , but not by @entity4 in anesthetized @entity0 . @entity2 , @entity4 and @entity6 exert indirectly a transient pulmonary vasodilatory action due to @entity1 evoked by strong systemic vasoconstriction, which may account for weak pulmonary pressor responses to these agents.

title: Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized XXXX .

answer: @entity0


abstract: INTRODUCTION: The increasing number of @entity0 requiring @entity2 treatment in South Africa calls for efficient use of its @entity0 resources for health in order to ensure optimum treatment coverage and outcomes. This paper describes an innovative public-private partnership model which uses private sector doctors to treat public sector @entity0 and ascertains the model's ability to maintain treatment outcomes over time. METHODS: The study used a retrospective design based on the electronic records of @entity0 who were down-referred from government hospitals to selected private general medical practitioners (GPs) between November 2005 and October 2012. In total, 2535 unique @entity0 records from 40 GPs were reviewed. The survival functions for mortality and attrition were calculated. Cumulative incidence of mortality for different time cohorts (defined by year of treatment initiation) was also established. RESULTS: The median number of @entity0 per GP was 143 (IQR: 66-246). At the time of down-referral to private GPs, 13.8% of the @entity0 had @entity1 count <200 cell/mm3, this proportion reduced to 6.6% at 12 months and 4.1% at 48 months. Similarly, 88.4% of the @entity0 had suppressed viral load (defined as @entity3 RNA <400 copies/ml) at 48 months. The @entity0 ' probability of survival at 12 and 48 months was 99.0% (95% CI: 98.4%-99.3%) and 89.0% (95% CI: 87.1%-90.0%) respectively. @entity0 retention at 48 months remained high at 94.3% (95% CI: 93.0%-95.7%). CONCLUSIONS: The study findings demonstrate the ability of the GPs to effectively maintain @entity0 treatment outcomes and potentially contribute to @entity2 treatment scale-up with the relevant support mechanism. The model demonstrates how an assisted private sector based programme can be effectively and efficiently used to either target specific health concerns, key populations or serve as a stop-gap measure to meet urgent health needs.

title: A South African Public-Private Partnership XXXX Treatment Model: Viability and Success Factors.

answer: @entity2


abstract: UNASSIGNED: @entity7 is one of the new oral anticoagulants, which is prescribed as an alternative to @entity6 antagonists (VKAs). Concerns regarding its @entity3 profile persist and require further evaluation. Therefore, we conducted a meta-analysis of @entity1 ( @entity1 ) to compare the risks of @entity3 and all-cause mortality between @entity7 and VKAs. The MEDLINE, EMBASE, and Cochrane Library of Clinical Trials databases were systematically searched for @entity1 comparing the risks of @entity3 and all-cause mortality of @entity7 (2.5 or 5  mg twice daily) with those of VKAs. We included @entity1 conducted in adults and published in English or French. Data were pooled across @entity1 using random-effects meta-analytical models. Our systematic search identified 5 @entity1 meeting our inclusion criteria (n  = 24,435). They included @entity0 with @entity4 (n  = 18,358), total knee replacement surgery (n  = 458), and @entity5 (n  = 5,619). Data pooled across @entity1 revealed that @entity7 was associated with reduced risks of any @entity3 (relative risk [RR] 0.73, 95% confidence interval [CI] 0.59 to 0.90) and a composite of major or clinically relevant nonmajor @entity3 (RR 0.60, 95% CI 0.40 to 0.88). @entity7 was also associated with a lower risk of @entity2 (RR 0.42, 95% CI 0.31 to 0.58) whereas analyses of major and minor @entity3 were inconclusive. Moreover, @entity7 was associated with decreased all-cause mortality (RR 0.89, 95% CI 0.81 to 0.99) although this finding was driven by the results of the ARISTOTLE trial. In conclusion, our meta-analysis found that @entity7 is associated with a lower risk of @entity3 than VKAs, providing some reassurance regarding its safety.

title: A Meta-Analysis of Randomized Controlled Trials of the Risk of Bleeding With @entity7 Versus XXXX Antagonists.

answer: @entity6


abstract: BACKGROUND/AIMS: Bone @entity2 is often complicated in hemodialysis (HD) @entity0 . @entity3 is related to @entity1 and @entity4 , but it is not known whether acid-base disturbance is associated with the risk of @entity2 . The aim of this study was to clarify the association of serum @entity5 level with @entity2 in HD @entity0 . METHODS: Using a subcohort of the Mineral and Bone Disorder Outcomes Study for Japanese CKD Stage 5D @entity0 (MBD-5D), 890 prevalent HD @entity0 (age: 62 years old, male: 62.8%, duration of dialysis: 8.3 years) with @entity6 were studied. After measuring predialysis serum @entity5 at a 2-day interdialytic interval, we prospectively followed them every 3 months, and examined the occurrence of any type of @entity2 or hospitalization due to @entity2 over a 3-year observation period. RESULTS: Seventy-four @entity2 and 47 hospitalizations due to @entity2 were observed during the follow-up period. HD patients with serum @entity5 <20 mmol/l had a 1.93 (95% CI 1.01-3.71)-fold higher risk for all-cause @entity2 than those with serum @entity5 of 20.0-21.9 mmol/l. A higher @entity5 level (>= 22 mmol/l) was also related to an increased risk of @entity2 . A restricted cubic regression spline disclosed that the higher or the lower than 21.0 mmol/l of serum @entity5 , the greater the risk for @entity2 . CONCLUSION: Both a lower level and a higher level of predialysis @entity5 concentration were associated with risk of @entity2 in HD @entity0 with @entity6 .    2014 S. Karger AG, Basel.

title: Association of Serum @entity5 with Bone Fractures in Hemodialysis @entity0 : The Mineral and Bone Disorder Outcomes Study for Japanese CKD Stage 5D XXXX (MBD-5D).

answer: @entity0


abstract: Objective: To examine the prevalence and predictors of potentially inappropriate anticholinergic medication use in older adults with @entity2 . Design: A cross-sectional study. Setting: United States, 2009-2010. @entity0 : Medical Expenditure Panel Survey household component @entity0 aged 65 years or older identified as having @entity2 and using potentially inappropriate anticholinergic medication. Main outcome measures: Prevalence and predictors of potentially inappropriate anticholinergic medication use as per the updated 2012 American Geriatrics Society Beers criteria. Results: A total of 3.78 million older adult @entity0 (95% confidence interval [CI] 3.17 million to 4.38 million) were identified as having @entity2 , for an overall prevalence of 4.81%. Of those @entity0 , an estimated 1.02 million (95% CI 0.70 million to 1.30 million) were reported to use potentially inappropriate anticholinergic medications, for an overall prevalence of 26.95% (95% CI 20.10% to 33.79%). The most frequently prescribed drugs were @entity9 , @entity5 , @entity3 , @entity6 , @entity7 , and @entity8 . Multivariable logistic analysis revealed that those @entity0 with the need characteristics of self-reported @entity1 , @entity4 , and "fair/poor" general health status had increased odds of potentially inappropriate anticholinergic use, while @entity0 with the predisposing characteristic of being aged 75-84 years had decreased odds of potentially inappropriate anticholinergic use. Conclusion: More than one in four older adults with @entity2 were found to use potentially inappropriate anticholinergics. Given the adverse cognitive effects of these medications, there is a strong need to monitor and optimize their use in older adult @entity0 with @entity2 .

title: Potentially inappropriate anticholinergic medication use in older adults with XXXX .

answer: @entity2


abstract: OBJECTIVE: To analyze the association between @entity1 and @entity6 . METHODS: We reviewed five cases of @entity1 that ruptured, producing acute @entity6 . The surgical management and diagnostic methods used are assessed. RESULTS: Five male @entity0 ranging in age from 6 to 25 years sustained the rupture of @entity1 , which produced acute @entity6 . Four of the @entity0 had incurred blunt @entity4 . All @entity0 presented with symptoms referable to @entity3 . The pathognomonic features of a middle fossa @entity1 (MFAC) were noted on the computed tomographic scans and/or magnetic resonance images of each @entity0 . The @entity5 exerted mass effect on the ipsilateral hemisphere and was noted to be under significant pressure at the time of surgical intervention in each case. Two of the five cases are unique in the literature. In one, a coexisting quadrigeminal cyst ruptured, producing a @entity6 ipsilateral to the MFAC and dilating the basal cisterns. In the other, the MFAC ruptured into the basal cisterns as well as into the subdural space. The MFAC in each of the remaining three @entity0 ruptured into the subdural space alone. All @entity0 were treated with drainage of the subdural space. In the two @entity0 in whom the basal cisterns were involved, both the @entity5 and the MFACs failed to change significantly in size. The @entity5 resolved completely and the MFACs decreased in size considerably in the three @entity0 without cisternal involvement. CONCLUSION: The rupture of an @entity1 can produce a @entity6 and @entity3 . The latter mandates emergent drainage of the subdural space. In @entity0 in whom the basal cisterns are not dilated by @entity2 , both the MFACs and @entity5 resolve after subdural drainage.

title: XXXX rupture producing @entity6 and @entity3 : case reports.

answer: @entity1


abstract: To evaluate prospectively the effect on mortality of wine drinking in Eastern France, we conducted an analysis on 34,014 consecutive middle-aged @entity0 coming for a comprehensive health appraisal between 1978 and 1983. We evaluated education, physical activity, smoking, and drinking habits by a questionnaire. Electrocardiogram, blood pressure, serum total @entity3 , and gamma-glutamyltransferase level were routinely measured. Seventy-seven per cent of the subjects drank wine; there was little difference between social classes in this proportion. We evaluated mortality over 10-15 years of follow-up. We estimated the relative risk (RR) of @entity5 by Cox proportional hazard models using nondrinkers as the reference and adjusting for six covariables. For an intake of 22-32 and 33-54 gm of @entity4 per day, the RR of all-cause @entity5 was 0.70 [95% confidence interval (CI) = 0.59-0.82] and 0.76 (95% CI = 0.66-0.87), respectively. The lower mortality resulted from fewer deaths from @entity2 and @entity1 . Above 128 gm per day of @entity4 consumption, the RR was 1.37 (95% CI = 1.16-1.61). A moderate intake of wine (2-5 glasses per day) was associated with a 24-31% reduction in all-cause mortality, a proportion that was similar for smokers, ex-smokers, and nonsmokers.

title: @entity4 and mortality in middle-aged XXXX from eastern France.

answer: @entity0


abstract: OBJECTIVE: The aim of this study was to examine the structural characterization of erythroid and megakaryocytic cell differentiation in Friend erythroleukemic cells using spectral imaging and electron microscopy. MATERIALS AND METHODS: Two variants of Friend @entity5 cells were treated with @entity7 ( @entity7 ) to induce differentiation: 1) @entity8 , which exhibit the normal phenotype and are susceptible to differentiation; and 2) the resistant R1 cells. The cells were analyzed by spectral imaging along with transmission and scanning electron microscopy. The expression of cell cycle regulatory proteins was analyzed by Western blotting. RESULTS: Spectral imaging of @entity7 -treated @entity8 and R1 cells stained by May-Gr  nwald-Giemsa and subjected to spectral similarity mapping revealed five morphologic cell types: proerythroblast-like cells, normoblast-like cells, reticulocyte-like cells, megakaryocytes, and apoptotic cells. In @entity8 cells, both megakaryocytic differentiation characterized by nuclear lobes and erythroid differentiation characterized by accumulation of hemoglobin were detected; R1 cells were not committed to terminal differentiation. @entity7 -induced cell cycle arrest at G(1) affected the expression of regulatory proteins in a similar manner in both types of cells. Expression of @entity6 decreased and expression of @entity3 ( @entity3 ) increased. The level of the underphosphorylated form of @entity4 protein increased, inducing a decrease in the level of @entity0 . In addition, we detected a decrease in the expression of the anti-apoptotic regulator, @entity1 , and an increased expression of the pro-apoptotic regulator, @entity2 . CONCLUSIONS: Spectral imaging provides new insight for the morphologic characterization of erythroid and megakaryocytic cell differentiation as well as apoptosis. Image analysis was well correlated to cell cycle arrest and the expression of regulatory proteins.

title: Structural characterization of erythroid and megakaryocytic differentiation in Friend XXXX cells.

answer: @entity5


abstract: OBJECTIVE: In the presence of acute @entity2 and @entity3 of the wall, tracheo-bronchial defects are difficult to manage. The absence of adequate vascularization and the contaminated area prevent successful direct re-suturing. METHODS: In order to restore a sufficient blood supply we used a pedicled latissimus dorsi or a pectoralis major flap that was entered into the thorax after a 10-cm resection of the second rib. A portion of the muscle was fitted into the tracheo/bronchial defect by reinforced sutures. The remaining muscle was sutured to the tissue surrounding the defect. This method was applied in various septic conditions: Bronchial defects; complete dehiscence of the right (n = 6) or left (n = 1) main bronchus at the carinal level following resection for @entity1 (n = 4) or for @entity7 (n = 2) on nontuberculous @entity12 (n = 1). @entity13 ; (1) destruction of one third of the tracheal circumference involving the cricoid down to the fourth ring following tracheotomy in presence of a septic sternum after @entity14 and @entity9 ; (2) 30% dehiscence of the @entity5 and septic sternum following tracheal resection; (3) @entity10 involving tracheal and esophageal wall following a 7 cm long iatrogenous laceration of the intrathoracic @entity8 . RESULTS: In one case the latissimus dorsi developed @entity11 on day 2 and was replaced by the pectoralis major muscle which showed uneventful healing. In all other @entity0 the muscle flap resulted in an uneventful closure of the defect and recovery. CONCLUSIONS: Large, well vascularized, pedicled @entity4 ensure a safe closure of tracheo-bronchial defects or dehiscences even in presence of gross @entity3 and @entity6 .

title: Life-saving XXXX in tracheobronchial dehiscence following resection or trauma.

answer: @entity4


abstract: BACKGROUND: Many @entity4 are healed by the application of external compression. It has been suggested that bandages capable of producing greater compression enhance healing. The aim of this study was to compare the time to total healing of @entity4 in two groups of @entity0 treated with different compression regimens in a randomized prospective trial. METHODS: A total of 112 @entity0 was studied and all were treated with a @entity1 -impregnated paste bandage applied directly to the @entity3 . Fifty-seven @entity0 had the paste covered by Tensopress and 55 by Elastocrepe bandages. Both groups had a tubular bandage applied over the top to retain the bandage in place. All @entity3 were stratified and randomized within one of three size groups. The 'venous' aetiology of the @entity3 was confirmed on completion by @entity2 pump function tests. RESULTS: By 26 weeks, 58 per cent of the @entity0 treated with Tensopress and 62 per cent of those treated with Elastocrepe bandages were healed. The median healing times were 9 and 9.5 weeks respectively. Similar numbers of @entity0 were excluded or withdrawn from both groups. Large @entity3 healed significantly more slowly than small @entity3 . CONCLUSION: There was no significant improvement in venous @entity3 using higher compression elastic bandages.

title: Randomized clinical trial comparing the efficacy of two bandaging regimens in the treatment of XXXX .

answer: @entity4


abstract: OBJECTIVE: To identify a size cutoff below which it is safe to observe obscure @entity2 suspected of being metastases so that treatment of nonmetastases can be avoided. METHODS: Medical records from @entity0 who underwent linear accelerator-based radiosurgery from August 1991 to October 2001 were reviewed. Inclusion criteria were defined as @entity2 @entity1 volume less than 5 cm(3) (diameter, thick similar 2.1 cm) treated with a dose of 20 Gy or more. One hundred thirty-five @entity0 had 153 evaluable brain metastases with follow-up imaging that met inclusion criteria. Median age was 54 years (range, 18-79 yr). Lesion primaries were non-small-cell lung (n = 39), @entity4 (n = 44), renal (n = 37), breast (n = 18), colon (n = 3), @entity3 (n = 5), other (n = 5), and unknown primary (n = 2). Median @entity1 volume was 0.67 cm(3) (range, 0.06-4.58 cm(3)). The minimum peripheral dose was 20 Gy (n = 132) or 21 to 24 Gy (n = 21). At the time of analysis, the median follow-up for all @entity0 was 10 months (range, 0.2-99 mo). RESULTS: The 1- and 2-year actuarial local control rates for all of the lesions were 69 and 46%, respectively. For lesions of 1 cm (0.5 cm(3)) or less, the corresponding local control rates were 86 and 78%, respectively, which was significantly higher than the corresponding rates of 56 and 24%, respectively, for lesions larger than 1 cm (0.5 cm(3)) (P = 0.0016). CONCLUSION: A convincing @entity2 measuring less than 1 cm should be pursued aggressively. If the suspected @entity2 is ambiguous, observation is proposed up to a diameter of 1 cm. This is the first study in the literature to identify a 1-cm cutoff for radiosurgical control of small brain metastases, and validation by additional studies is required.

title: The role of @entity1 size in the radiosurgical management of XXXX with ambiguous brain metastases.

answer: @entity0


abstract: @entity8 ( @entity7 ) gene product, a transcription factor of the basic-helix-loop-helix type, is thought to play a role in the regulation of genes encoding the enzymes necessary for melanogenesis. These include @entity9 , @entity11 and @entity12 . Melanocyte-specific isoform of @entity8 , @entity7 -M, is expressed in normal and malignant melanocytes. The presence of two other isoforms of @entity8 , @entity7 -A and @entity7 -H, which differ from @entity7 -M in the @entity6 -terminus, was demonstrated also in some non-melanocytic lineages. Here we have analyzed the presence of all three known isoforms of @entity7 mRNA in a panel of 17 @entity0 @entity2 cell lines by a reverse transcriptase-polymerase chain reaction using isoform-specific primers. While, as expected, the predominant form in @entity2 cell lines was @entity7 -M, low amounts of @entity7 -A mRNA was found in almost all @entity2 , as well as in most of 20 @entity1 cell lines of the non-melanocyte origin (lung and @entity5 , @entity3 and @entity4 ). The expression of @entity7 -H was not detected, with a few exceptions, in the tested cell lines. @entity10 transcription factor was reported earlier to regulate positively the melanocyte-specific promoter of the @entity7 gene. We found here that the @entity10 mRNA was expressed in all @entity2 cell lines, even in those that had repressed the @entity7 -M and were amelanotic. This suggests that additional factors, besides @entity10 , are required for the @entity7 expression. The @entity13 ( @entity13 ), a gene originally isolated from melanocytes and containing a strong transcription activation domain, was also found expressed in all @entity2 and most @entity1 cell lines. Together, these data indicate that the @entity7 -M isoform is the major type of @entity7 mRNA present in @entity0 @entity2 cell lines and show that the expression of the isoform @entity7 -A and the @entity13 is not restricted to malignant melanocytes and occurs in a wide range of @entity1 cell lines.

title: Expression of genes for @entity8 isoforms, @entity10 and XXXX , in @entity0 @entity2 .

answer: @entity13


abstract: BACKGROUND: @entity2 ( @entity2 ) manifestations distant from the site of the @entity1 rarely arise as only sign of disease recurrence. METHODS: This report reviews 38 @entity0 with high-grade central @entity2 of the limbs or axial skeleton and initial complete surgical remission (CR) who developed first recurrences as solitary osseous lesions distant from the @entity1 . The @entity2 Study Group (COSS) database was used to evaluate @entity0 -, @entity1 -, and treatment-related variables and outcomes. RESULTS: Thirty-eight @entity0 (27 males and 11 females; 36 limb and 2 axial primaries) developed solitary osseous recurrences a median of 2.1 years (range: 0.5-14.3) from primary diagnosis. Relapses involved axial (24), extremity (10), or craniofacial bones (4). Treatment for recurrence included surgery (28), radiotherapy (10), and chemotherapy (27). After a median follow-up of 1.9 years (range: 0.1-21.2) from first recurrence for all 38 @entity0 and 5.5 years (0.3-21.2) for 16 survivors (10 in continuous second CR), 2- and 5-year overall and event-free survival (EFS) probabilities were 55% and 34% and 34% and 27%, respectively. A long interval to recurrence (>1.5 years) predicted for better overall (P < 0.001) and EFS (P = 0.005). For 21 @entity0 achieving a second CR, 2- and 5-year overall and EFS probabilities were 81% and 61% and 52% and 49%, respectively, while only 1/17 others survived beyond 5 years (P < 0.001). Survivors (14/16) had also received second-line chemotherapy. CONCLUSION: First solitary skeletal recurrences of @entity2 should be treated with curative intent. Some presumed bone metastases may represent second primary OSs.

title: XXXX recurrence. Findings from the @entity2 Study Group.

answer: @entity2


abstract: An eight-year-old Japanese @entity0 developed @entity3 , followed by @entity2 and @entity10 . He was taken to an emergency room but could not be resuscitated. At autopsy, the left main coronary trunk (LMT) demonstrated an increase in caliber with severe luminal narrowing, and the @entity6 ( @entity6 ) subsequent to the LMT showed severe @entity9 . Microscopically, the intima of the LMT demonstrated severe @entity1 and infiltration of lymphocytes and histiocytes suggesting @entity11 , and the small lumen was occupied by a fresh @entity7 . The @entity6 showed significant intimal thickening with strong lymphocytic inflammation at the edge of the thickening. The left ventricle showed widespread @entity5 in the recovery stage. There were no findings of @entity8 , @entity11 or fibrocellular changes in the ascending aorta or intravisceral arteries other than the LMT and the @entity6 under investigation. The increase in the caliber of the LMT and the limitation of @entity12 to the LMT and the subsequent branch suggested @entity4 ( @entity4 ), but it was atypical that the @entity0 had no clinical history consistent with @entity4 . The present case showed no findings suggesting classical @entity14 (cPAN) at the acute or scar stage in the other vessels being investigated, and cPAN in childhood is rare compared to @entity4 . A nonspecific inflammatory reaction (single organ @entity11 , SOV) was also considered as a possible cause, but it is difficult to determine whether the cause of the @entity13 in the present case was SOV because the sampling of arteries was insufficient. If forensic pathologists make unusual findings suggesting @entity11 at autopsy, the collection of a sufficient number of vessels of various sizes is warranted.

title: Sudden death of a @entity0 from @entity5 due to XXXX of the left coronary trunk.

answer: @entity12


abstract: Little is known about risk factors for @entity4 ( @entity4 ) and @entity3 ( @entity3 ) but maternal psychological morbidity in pregnancy may be associated with @entity4 / @entity3 . We examined whether pre- and post-natal parental @entity1 and/or @entity2 are associated with risk of @entity4 / @entity3 in the Avon Longitudinal Study of Parents and @entity0 . We compared self-reported @entity1 and @entity2 measures collected prospectively at four time points (18 and 32  weeks prenatally, and 8  weeks and 8  months post-natally) among parents of @entity0 who subsequently met criteria for @entity4 / @entity3 at 13  years of age as compared to other @entity0 from the cohort. We adjusted for various socioeconomic measures and tested both for time period-specific exposure and chronic exposure using multivariable logistic regression models. 122 @entity0 had @entity4 / @entity3 (50 @entity4 , 72 @entity3 ) and 5968 @entity0 had no tics. In crude analyses, both pre- and post-natal maternal @entity1 and @entity2 , but only post-natal paternal @entity2 at 8  months, showed associations with @entity4 / @entity3 . In the final, adjusted multivariable models, chronic maternal @entity1 (odds ratio 2.17, 95  % CI 1.23, 3.84, p  =  0.007) and pre-natal maternal @entity2 (odds ratio 1.86, 95  % CI 1.02, 3.39, p  =  0.04) showed associations with @entity4 / @entity3 though the latter was consistent with chance (p  =  0.07) after adjustment for past maternal @entity2 . We find associations between maternal psychological morbidity pre- and post-natally and risk of future @entity4 / @entity3 in offspring. These associations may reflect either shared genetic susceptibility or a pre-natal exposure. Further work is required to see if these findings can be replicated in larger datasets.

title: Parental mood during pregnancy and post-natally is associated with offspring risk of XXXX or chronic tics: prospective data from the Avon Longitudinal Study of Parents and @entity0 (ALSPAC).

answer: @entity4


abstract: UNASSIGNED: Introduction: Advanced @entity3 ( @entity3 ) is traditionally treated with @entity2 -based chemotherapy and radiotherapy. Since immunotherapy holds promise for treating advanced @entity3 , we assessed the systemic effects of the traditional therapies for @entity3 on immune cell composition and function. Methods: 84 @entity1 @entity0 , treated either with chemotherapy or radiotherapy, were studied. A prospective study of 23 @entity0 was conducted in which the myeloid and lymphoid cell compartments of peripheral blood were analyzed. Changes in cell populations were validated in a retrospective cohort of 61 @entity1 @entity0 using automated differential counts collected throughout therapy. Furthermore, the functional capacity of circulating T cells and @entity4 ( @entity4 ) was studied. Blood samples of healthy individuals were used as controls. Results: In comparison to healthy controls, untreated @entity1 @entity0 display an elevated frequency of myeloid cells coinciding with relative lower frequencies of lymphocytes and dendritic cells. Standard chemotherapy had no overt effects on myeloid and lymphoid cell composition nor on T-cell and @entity4 -function. In contrast, @entity0 treated with radiotherapy displayed a decrease in lymphoid cells and a relative increase in monocytes/macrophages. Importantly, these changes were associated with a reduced @entity4 function and an impaired response of T cells to recall antigens. Conclusions: @entity2 -based standard of care chemotherapy for @entity3 has no profound negative effect on the immune cell composition and function. The negative effect of prolonged low-dose radiotherapy on the immune system warrants future studies on the optimal dose and fraction of radiotherapy when combined with immunotherapy.

title: Standard radiotherapy but not chemotherapy impairs systemic immunity in XXXX .

answer: @entity3


abstract: High fat feeding reportedly enhances hypothalamus-pituitary-adrenal (HPA) responses to stress in adult @entity0 . The present study tested whether elevated fat intake during suckling could have short and/or long lasting consequences on HPA regulation in the offspring. Mothers were fed either a control (C; 5% fat) or @entity1 ( @entity1 ; 20% fat) diet during the last week of gestation and throughout lactation. After weaning (day 21), pups from C and @entity1 mothers were fed a chow diet. Offspring from both C- and @entity1 -fed mothers were tested for ACTH and @entity2 responses to stress on postnatal days 10 and 35. We found that @entity1 feeding produced higher lipid levels in the milk of @entity1 compared with C lactating @entity0 dams and that offspring of these mothers had significantly increased retroperitoneal fat pad weight and relative adipose mass on day 21 as well as elevated plasma @entity3 levels on days 10 and 21 of age. After weaning, pups from the @entity1 mothers had lower plasma @entity3 levels than those from C mothers. Maternal dietary fat affected HPA responsiveness in the offspring in an age-related manner. Neonatal pups (day 10) from the @entity1 mothers exhibited a reduction in the ACTH and @entity2 responses to ether stress. However, in 35-day-old offspring from @entity1 -fed dams, stress-induced ACTH secretion was increased compared with that in pups from the C-fed mothers. These results demonstrate that maternal diet and increased fat intake through the milk are important regulators of HPA responsiveness in neonates and prepubertal @entity0 . During neonatal life, the blunted stress responsiveness seen with elevated fat intake and the resulting high @entity3 levels might protect the pups from excessive HPA activation. After removal of the maternal dietary influence and reduced @entity3 levels, enhanced ACTH stress responses are observed as in adult @entity0 fed a @entity1 diet. Because of the inverse relationship between plasma levels of @entity3 and HPA responses in pups, the possibility exists that the effects of the @entity1 diet on stress responsiveness are mediated by changes in @entity3 exposure during development.

title: Increased fat intake during lactation modifies hypothalamic-pituitary-adrenal responsiveness in developing XXXX pups: a possible role for @entity3 .

answer: @entity0


abstract: AIM: To determine the frequency and pattern of @entity9 in @entity0 with @entity6 ( @entity6 ) and to evaluate the adequacy of preventive anticoagulant or antiaggregant therapy. SUBJECTS AND METHODS: The prospective study conducted at the Department for High-Dose Chemotherapy and Bone Marrow Transplantation, Hematology Research Center, Ministry of Health of the Russian Federation, in March 2012 to May 2013, enrolled 25 @entity0 (13 @entity0 and 12 @entity0 ) aged 29-72 years (median age 54 years) with new-onset @entity6 . The latter was staged using the Durie-Salmon classification: Stages I, II, and III were determined in 2, 10, and 13 @entity0 , respectively. Seven @entity0 were found to have @entity1 (which corresponded to Substage B). The hemostasis was evaluated from the results of the following tests: activated partial thromboplastin time (APTT), @entity4 time (TT), Xlla-dependent fibrinolysis time, Quick prothrombin index, international normalized ratio (INR), and @entity7 and D-dimer concentrations. The investigators used new hemostatic techniques, such as @entity4 generation test, thromboelastography, as well as thrombodynamics, a novel method to determine the characteristics of spatial clot growth. Induction therapy was performed using the PAD and VCD regimens. @entity5 were prevented by using 24-hour infusion of unfractionated heparin (500 U/hr) or by administering @entity3 (100 mg/day). RESULTS: @entity2 was identified in 17 (68%) @entity0 . Eleven (44%) @entity0 had elevated D-dimer concentrations. The level of D-dimer was statistically significantly positively correlated with the endogenous @entity4 potential and the amount of @entity8 . The thrombodynamic technique revealed an inverse relationship between the level of paraprotein and the optimal density of a fibrin clot. A @entity5 episode was seen in one elderly (71-year-old) @entity0 after @entity3 discontinuation during long-term immobilization. CONCLUSION: Nearly 50% of the primary @entity0 with @entity6 were ascertained to be more prone to @entity5 . Infusion of unfractionated heparin in a dose of 500 U/hr or administration of @entity3 (100 mg/day) was the adequate prevention of @entity5 events.

title: [ @entity2 in XXXX ].

answer: @entity6


abstract: INTRODUCTION: Although @entity4 is the most common complication of @entity7 ( @entity7 ), the clinical impact of @entity4 on disease course and survival has not been fully estimated. Thus, we retrospectively analyzed the prognostic factors and clinical consequences of @entity1 in @entity7 . METHODS: The clinical course of @entity0 with @entity4 was surveyed. The association between baseline clinical features (2 years from disease onset) and latency to the initial development of @entity1 was investigated using survival time and Cox regression analyses. RESULTS: Ninety @entity0 with a clinical diagnosis of @entity7 were observed for 5.1  3.8 years (mean  SD), and 22 had @entity4 . Subsequently, 20 @entity0 (91%) had to discontinue oral feeding entirely and 13 (59%) died, whereas, of 68 @entity0 without @entity1 , only three @entity0 (4%) died. Time to initial development of @entity1 was strongly correlated with survival time (Spearman R = 0.92, P<0.001), with a mean latency of 2.3 years to @entity3 . Among baseline clinical features, @entity6 and @entity2 were significant predictors of @entity1 (P = 0.001 and P<0.001, respectively, log rank test). Cox regression analysis demonstrated that @entity6 (adjusted hazard ratio: 3.9, 95% confidence interval: 1.2-12.5, P = 0.03) and @entity2 (adjusted hazard ratio: 5.2, 95% confidence interval: 1.4-19.3, P = 0.02) independently predicted @entity1 . By contrast, @entity5 was not associated with @entity1 (P = 0.2, log rank test). CONCLUSION: Initial development of @entity1 indicates an unfavorable clinical course and predicts survival time (mean survival time 2.3 years). @entity0 with early falls and @entity2 were at high risk of early development of @entity1 .

title: Impact of XXXX on the Clinical Course of @entity7 : A Retrospective Cohort Study.

answer: @entity4


abstract: UNASSIGNED: Diffuse low-grade @entity2 are rare primitive @entity1 of adults. These @entity1 progress continuously over time and then turn to a higher grade of @entity1 associated with @entity3 , leading ultimately to @entity4 . @entity1 size is one of the most important prognostic factors. Thus, it is of great importance to be able to assess the volume of the @entity1 during the @entity0 ' monitoring. MRI is nowadays the recommended modality to achieve this. Furthermore, if surgery remains the first option for diffuse low-grade @entity2 , chemotherapy is increasingly used (before or after a possible surgery). However, crucial and difficult questions remain to be answered: identifying subgroups of @entity0 who could benefit from chemotherapy, determining the best time to initiate chemotherapy, defining the duration of chemotherapy and evaluating the optimal time to perform surgery, or otherwise radiotherapy. In this study, we propose to help clinicians in decision-making, by designing new predictive models dedicated to the evolution of the diameter of the @entity1 . Two proposed statistical models (linear and exponential) have been validated on a database of 16 @entity0 whose @entity5 -based chemotherapy lasted between 14 and 32 months, with an average duration of 22.8 months. The selection of the most appropriate model has been achieved with the corrected Akaike's Information Criterion. The results are very promising, with coefficients of determination varying from 0.79 to 0.97 with an average value of 0.90 for the linear model. This shows it is possible to alert the clinician to a change in the @entity1 diameter's dynamics.

title: Predictive models for diffuse low-grade XXXX @entity0 under chemotherapy.

answer: @entity2


abstract: Between 1975 and 1983, 9434 colonoscopic examinations were performed at the University Hospital of Z  rich. @entity2 was detected in 84 @entity0 and there were 48 mucosal biopsies from 46 @entity0 . From the total of 48 biopsies only 24 (50%) showed @entity2 . The most frequent lesion encountered was groups of thin-walled dilated vessels in the lamina propria seen in 21 biopsies from 20 @entity0 . These dilated vessels are not specific but in respect of age (median 69 years), location (predominantly in the caecum and the ascending colon) and frequent multiplicity, they are suggestive of @entity4 . Five of the 20 @entity0 suffered from @entity1 due to @entity3 . The three other positive biopsies (from two @entity0 ) revealed a tiny haemangioma in the sigmoid colon of a 28-year-old @entity0 and a few large, thick-walled probably malformed vessels in the mucosa of the caecum of a 17-year-old @entity0 . Twenty-four biopsies did not show any histologically significant @entity2 . Mucosal biopsy of @entity2 detected during routine colonoscopic examination will, if positive, most frequently simply confirm the endoscopically diagnosed @entity2 and may in rare cases show or alert suspicion to @entity2 other than @entity4 . Definitive morphological diagnosis will however only rarely be achieved by this method of investigation.

title: Mucosal biopsy of XXXX ( @entity4 ) of the large bowel detected during routine colonoscopic examination.

answer: @entity2


abstract: Transplant @entity5 (TRAS) is a cause of severe post transplant @entity2 with a widely variable reported incidence from 1 to 25%. We herein report 3 cases of endoluminal stent placement after percutaneous transluminal angioplasty for treatment of TRAS. Clinical and laboratory findings during their follow-up, suggestive of TRAS included: elevated mean blood pressure, bruit over the graft area(2/3), and increase in serum @entity4 (2/3). Doppler sonography, radioisotope renography and arteriography were performed to confirm TRAS diagnosis. The series includes 2 female and 1 male @entity0 ; the time elapsed between transplantation and TRAS diagnosis was 25 d, 12 and 65 months, respectively. All grafts were from living related donors. @entity0 received at least 3 antihypertensive drugs without adequate blood pressure control. Vascular @entity3 was end to end from the renal to the hypogastric artery in two cases, and end to side to the external iliac artery in the other one. After the diagnosis of TRAS, percutaneous transluminal angioplasty with endoluminal metallic Palmaz stent placement was accomplished in the three cases. No complications occurred during or after the procedures. Beneficial clinical results were obtained in all cases documented by a decrease in both: serum @entity4 , and mean blood pressure. Average follow-up after stent placement was 13, 19 and 36 months, respectively without evidence of stenosis recurrence CONCLUSIONS: Percutaneous transluminal angioplasty with stent placement is a safe and effective treatment for TRAS associated @entity2 and @entity1 . Extended follow-up is necessary to evaluate long-term efficacy and safety of this procedure.

title: [ XXXX after transplantation: treatment using percutaneous transluminal angioplasty and placement of an expandable metal luminal prosthesis].

answer: @entity5


abstract: BACKGROUND AND AIMS: High serum @entity5 to high-density lipoprotein @entity3 (TG/HDL-C) ratio has been found to be an independent predictor for cardiovascular events in the general population. We aimed to evaluate whether a high TG/HDL-C ratio was associated with an increased risk of mortality in @entity0 on continuous ambulatory @entity4 (CAPD). METHODS AND RESULTS: In this single-center retrospective cohort study, 1170 incident @entity0 on @entity4 ( @entity4 ) from 1 January 2007 to 31 December 2011 were recruited and followed up until 31 December 31 2013. The mean age was 47.4      15.2 years, and 24.7% were @entity1 . During a median of the 34.5-month follow-up period, 213 (18.2%) deaths occurred, 121 of which (56.8%) were caused by @entity2 ( @entity2 ). The serum median TG/HDL-C ratio at baseline was 2.57 (range: 0.06-39.39). On multivariate Cox regression analysis, the highest quartile of the TG/HDL-C ratio (>= 4.19) was associated with increased risk of all-cause mortality (hazard ratio (HR) 1.98, 95% confidence interval (CI), 1.17-3.36; P  =  0.011) and @entity2 mortality (HR 2.28, 95% CI, 1.16-4.47; P  =  0.017). For female @entity0 , each one-unit higher baseline TG/HDL-C was associated with 13% (95% CI 1.06-1.22; P  =  0.001) increased risk of @entity2 mortality, whereas such an association was not observed for male @entity0 , (HR 1.00, 95% CI 0.92-1.08; P  =  0.977). CONCLUSIONS: A higher serum TG/HDL-C ratio was associated with an increased risk of all-cause and @entity2 mortality in @entity4 @entity0 . Moreover, the increased risk of @entity2 mortality was significantly higher in female than male @entity4 @entity0 .

title: Higher serum @entity5 to high-density lipoprotein @entity3 ratio was associated with increased cardiovascular mortality in female @entity0 on XXXX .

answer: @entity4


abstract: OBJECTIVE: To examine endolymphatic hydrops (EH) using magnetic resonance imaging (MRI) in @entity0 with definite @entity1 ( @entity3 ) and those with nonotological diseases. METHODS: We studied 32 @entity0 with unilateral @entity3 , 10 @entity0 with bilateral @entity3 and 21 @entity0 with control ears who had other benign diseases not associated with @entity2 . The mean age of the subjects was 54.0 years (range 27-74) in the @entity3 group and 56.1 years (range 24-79) in the control group. Using MRI, the degree of EH was classified as none, mild and significant in the cochlea and vestibule separately. The ratio of the area of endolymphatic space to the vestibular fluid space was calculated for the vestibule. The duration of @entity3 was defined as the months between the first attack of @entity3 and the MRI study. RESULTS: EH was present in the cochlea of 45/52 affected ears of @entity0 with @entity3 (87%) and in 16/42 control ears (38%). Significant @entity4 was present in 37/52 affected ears (71%) and in 4/42 control ears (10%). EH in the vestibule was present in 49/52 affected ears (94%) and in 3/42 control ears (7%). Significant vestibular hydrops was present in 40/52 affected ears (77%) and in none of the 42 control ears. There was no relationship between the degree of EH and its duration. Using a cut off value for the relative size of EH in the vestibule of 41.9%, the test had a sensitivity of 88.5% and a specificity of 100% to diagnose definite @entity3 . CONCLUSION: Cochlear EH was occasionally observed in control ears on MRI, as in normal temporal bone specimens. The presence or absence and degree of vestibular EH were significantly different between ears with @entity3 and control ears. EH in the vestibule might be a specific predictor of definite @entity3 .

title: Imaging of the endolymphatic space in XXXX with @entity1 .

answer: @entity0


abstract: PURPOSE: To evaluate the accuracy of residual microcalcifications on mammogram (MG) in predicting the extent of the @entity3 after neoadjuvant systemic treatment (NST) in @entity1 with locally advanced @entity0 and to evaluate factors affecting the accuracy of MG microcalcifications using magnetic resonance imaging (MRI) as a reference. METHODS: The @entity1 who underwent NST and showed suspicious microcalcifications on MG comprised our study population. Clinicopathologic and imaging (MG, MRI) findings were investigated. Agreement between image findings and pathology was assessed and factors affecting the discrepancy were analyzed. RESULTS: Among 207 @entity1 , 196 had @entity4 or @entity4 -in-situ (mean size, 3.78  cm). The overall agreement of residual microcalcifications on MG predicting @entity3 extents was lower than MRI in all @entity2 subtypes (intraclass correlation coefficient [ICC]  =  0.368 and 0.723, p  <  0.0001). The agreement of residual MG microcalcifications and pathology was highest in HR(+)/ @entity5 (+) @entity2 and lowest in the @entity2 (ICC  =  0.417 and 0.205, respectively). Multivariate linear regression analysis revealed that a size discrepancy between microcalcifications and histopathology was correlated with molecular subtype (p  =  0.005). In HR(+)/ @entity5 (-) and triple-negative subtypes, the mean extents of residual microcalcification @entity2 , and overestimation of @entity2 extent was more frequent in HR(+)/ @entity5 (+) and HR(-)/ @entity5 (+) @entity2 . CONCLUSIONS: The extent of microcalcifications on MG after NST showed an overall lower correlation with the extent of the pathologic @entity3 than enhancing lesions on MRI. The accuracy of @entity3 evaluation after NST with MG and MRI is affected by their molecular subtype.

title: Residual Mammographic Microcalcifications and Enhancing Lesions on MRI After Neoadjuvant Systemic Chemotherapy for Locally Advanced @entity0 : Correlation with Histopathologic XXXX Size.

answer: @entity3


abstract: OBJECTIVES: In vitro and in vivo animal studies suggest that sex @entity6 , such as @entity4 and @entity7 , could protect the brain. However, @entity4 replacement therapy (ERT) for @entity5 ( @entity5 ) in @entity0 has not been successful. We hypothesised that the lack of effect of ERT might be related to an interaction between @entity4 and some other factor(s) associated with @entity5 . DESIGN, SETTING AND METHODS: We analysed total @entity4 (TE) and @entity7 (TT) levels in @entity0 diagnosed with @entity5 and controls of the Oxford Project To Investigate Memory and Ageing. Because @entity2 ( @entity13 ) after the menopause is largely derived from @entity11 (TE1), we computed the ratio @entity13 /(TE1+ @entity13 ) and a total @entity3 index (TT+ @entity13 +TE1). RESULTS: @entity0 with @entity5 (n=66) had significantly higher levels of @entity13 (27+/-13 vs. 21+/-13) and a higher @entity13 /(TE1+ @entity13 ) ratio. Stepwise logistic regression analyses showed that the @entity13 /(TE1+ @entity13 ) ratio was the main sex @entity3 predictor for @entity5 (O.R.=1.06, 95% C.I.=1.01-1.11, p<0.01). Multiple regression analyses revealed that @entity8 severity was associated with an interaction between the @entity13 /(TE1+ @entity13 ) ratio and serum @entity10 (B=4.59 (SE=1.48), beta=1.22, 95% C.I.=1.62-7.56, p<0.005). None of the other potential mediators of this association (body mass index, sex hormone binding globulin, @entity9 levels, @entity12 genotype, smoking, @entity1 , blood pressure) was significant. MAIN FINDINGS: A high ratio of @entity2 to total @entity4 is associated with @entity5 but, in subjects with a high ratio, the @entity8 severity was lower in those with high serum @entity10 levels. CONCLUSIONS: If this association is causal, then supplementation with @entity10 might be considered in future studies on ERT in @entity5 .

title: The interaction of serum XXXX and @entity2 levels in @entity5 .

answer: @entity10


abstract: BACKGROUND: If carotid endarterectomy (CEA) is a clinical model of @entity1 , then it should be possible to determine the relevance of embolus size and of the total quantity of embolic material ( @entity4 ) for @entity2 . MATERIAL/METHODS: Thirty-one @entity0 underwent a total of 33 CEAs. Diffusion weighted imaging (DWI) was performed on the day before and after CEA. A new hyperintense signal on the postoperative DWI was considered a new @entity5 . Intraoperatively detected @entity6 ( @entity6 ) were quantified (in cm) by multiplying @entity4 within the Doppler sample volume. With this relative index, emboli were classified into small (<0.56 cm), medium-sized (0.56-1.12 cm) and large (1.12-1.70 cm). RESULTS: For each category of embolus size, @entity4 (in cm/minute) was expressed as the sum of all quantified emboli divided by minutes of CEA duration. By logistic regression analysis, the occurrence of a new @entity5 was related to an @entity4 with medium-sized emboli (without lesion, 0.029 cm/minute; with lesion, 0.157 cm/minute; p=0.018), and with large emboli (without lesion, 0.015; with lesion, 0.055; p=0.038), but not to an @entity4 with small emboli or the largest embolus per CEA. CONCLUSIONS: The leading reason for @entity5 in CEA is multiple @entity4 with emboli of medium and large size. This conceptual model may also apply to carotid @entity3 .

title: XXXX in carotid surgery: a model for @entity0 @entity1 ?

answer: @entity5


abstract: Pluripotent stem cells are increasingly used for therapeutic models, including transplantation of neural progenitors derived from @entity0 embryonic stem cells (hESC). Recently, long noncoding RNA (lncRNA), including @entity5 ( @entity5 ) derived from the @entity4 - @entity6 -imprinted locus, were found to be expressed during neural developmental events. Their deregulations are associated with various @entity2 . The @entity4 - @entity6 -imprinted locus encodes abundant noncoding RNA (ncRNA) that are regulated by differential methylation on the locus. The aim of our research was to study the correlation between the @entity4 - @entity6 -derived ncRNA and the capacity of hESC neural lineage differentiation. We classified hESC into @entity5 -ON and @entity5 -OFF based on the expression levels of @entity5 as well as its downstream microRNA by qRT-PCR. Initial embryoid body (EB) formation was conducted to examine the 3 germ layer's differentiation ability. Complementary DNA microarray was used to analyse the gene expression profiles of hESC. Directed neural lineage differentiation was performed, followed by analysis of neural lineage marker expression levels and neurite formation via qRT-PCR and immunocytochemistry methods to investigate the capacity of neural differentiation in @entity5 -ON and @entity5 -OFF hESC. As for statistics, error bars indicate standard error of the mean. Student's t-test was used for calculating P-values, and a P-value of less than 0.05 was considered to be significant. Our results showed that @entity5 -ON and @entity5 -OFF hESC differed greatly in @entity4 - @entity6 -derived ncRNA expression levels, but had comparable pluripotency gene expression profiles. Genes related to nervous system development and @entity1 were differentially expressed in @entity5 -OFF hESC, where @entity4 - @entity6 -derived ncRNA were repressed compared to @entity5 -ON ones before differentiation. In neural lineage-like cells derived from @entity5 -OFF hESC, lower expression levels of neural lineage markers and @entity3 were observed compared to @entity5 -ON hESC at the same time points after differentiation. We suggest that the expression of @entity4 - @entity6 -derived lncRNA, @entity5 , can be used as a simple and effective screening criterion for identifying @entity5 -ON hESC with activation of @entity4 - @entity6 -imprinted ncRNA as starting materials to benefit neural lineage-associated studies.

title: 346 expression of imprinted noncoding RNA from the @entity4 - XXXX locus in @entity0 embryonic stem cells advantages neural lineage differentiation.

answer: @entity6


abstract: BACKGROUND AND AIM: @entity6 (PG) E2 promotes @entity3 and @entity1 progression. The total amount of biologically active @entity5 in tissues is determined by a balance of PG biosynthesis and degradation pathways, which involve the PG transporter (PGT). We investigated PGT in @entity4 by determining its expression pattern and examining associations of PGT with prognosis and @entity1 angiogenesis. METHODS: PGT expression was determined by immunohistochemistry in advanced @entity4 specimens obtained from 96 @entity0 who underwent surgical resection. Correlations between PGT expression level and clinicopathological factors were statistically analyzed. Angiogenesis in the @entity1 tissue was evaluated by counting the number of microvessels. The role of PGT in mRNA and protein expression of @entity2 ( @entity2 ) was examined in @entity4 cells stimulated by @entity5 . RESULTS: Based on multivariate and Kaplan-Meier analyses, negativity for PGT expression was an independent poor prognostic factor. There were more microvessels in PGT-negative @entity1 than in PGT-positive @entity1 . Transfection of @entity7 and MKN7 @entity4 cells with PGT-specific siRNA led to increased @entity2 mRNA and protein expression accompanied by increased @entity5 in the culture media. CONCLUSIONS: PGT expression is an independent predictor of poor survival and is associated with @entity1 angiogenesis in @entity4 .

title: Reduction of @entity6 transporter predicts poor prognosis associated with angiogenesis in XXXX .

answer: @entity4


abstract: AIMS: In healthy @entity0 , brachial artery @entity2 infusion elicits a reflex increase in total body @entity3 (NE) spillover ( @entity7 ) that is blunted by oral angiotensin @entity4 (1) receptor blockade. Our objectives were to determine whether a similar reflex is active in treated @entity1 ( @entity1 ) @entity0 and attenuated by ARB. METHODS AND RESULTS: In this double-blind study, 12 @entity0 with an ejection fraction  <=40% were randomized to 2 weeks of oral @entity5 up-titrated to 32 mg/day or placebo. Forearm blood flow was measured bilaterally by venous occlusion plethysmography. Total body NE spillover was determined following infusion of tritiated NE. After saline was infused into the non-dominant brachial artery to establish baseline values, @entity2 and @entity6 (as vasodilator control) were administered in random order. Both caused dose-dependent increases in ipsilateral but not contralateral blood flow. @entity6 had no @entity7 effect, whereas @entity2 reduced @entity7 from 3967 (SD 2362) to 3293 pmol/min (SD 2093) (P = 0.03). This decrease was not augmented in @entity5 -treated subjects [-1096 (SD 726) vs. -253 pmol/min (SD 1094); placebo vs. @entity5 ; P = 0.22]. CONCLUSIONS: In contrast to healthy @entity0 , in treated @entity1 @entity0 , locally infused @entity2 does not elicit a reflex sympatho-excitatory response mediated by angiotensin @entity4 (1)-modulated neurotransmission.

title: Reflex systemic sympatho-neural response to brachial @entity2 infusion in treated XXXX .

answer: @entity1


abstract: Pulsed arterial spin labeling magnetic resonance imaging (MRI) was performed to investigate the local coupling between resting regional cerebral blood flow ( @entity4 ) and BOLD (blood @entity1 level dependent) signal changes in 22 normal @entity0 subjects during the administration of 0.25 MAC (minimum alveolar concentration) @entity3 . Two states were compared with subjects at rest: anesthesia and no-anesthesia. Regions of both significantly increased and decreased resting-state @entity4 were observed. Increases were limited primarily to @entity2 , whereas, decreases were observed primarily in neocortical regions. No significant change was found in global @entity4 (gCBF). By simultaneously measuring @entity4 and BOLD, region-specific anesthetic effects on the coupling between @entity4 and BOLD were identified. Multiple comparisons of the agent-induced @entity4 and BOLD changes demonstrated significant (P < 0.05) spatial variability in @entity4 -BOLD coupling. The slope of the linear regression line for AC, where @entity4 was increased by @entity3 , was markedly smaller than the slope for those ROIs where @entity4 was decreased by @entity3 , indicating a bigger change in BOLD per unit change in @entity4 in regions where @entity4 was increased by @entity3 . These results suggest that it would be inaccurate to use a global quantitative model to describe coupling across all brain regions and in all anesthesia conditions. The observed spatial nonuniformity of @entity4 and BOLD signal changes suggests that any interpretation of BOLD fMRI data in the presence of an anesthetic requires consideration of these insights.

title: Spatial nonuniformity of the resting CBF and BOLD responses to XXXX : in vivo study of normal @entity0 subjects with magnetic resonance imaging.

answer: @entity3


abstract: AIMS/HYPOTHESIS: The role of biomarkers of subclinical @entity2 in the early deterioration of glycaemia before @entity3 2 @entity1 is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating @entity5 would be associated with 7  year increases of HbA1c in non- @entity1 individuals. METHODS: This study was based on individuals who participated in the prospective Cooperative Health Research in the Region of Augsburg (KORA) S4 survey (1999-2001) and the 7  year follow-up KORA F4 (2006-2008) survey. Individuals with @entity3 2 @entity1 at baseline or with a diagnosis of @entity1 in the period between both surveys were excluded, which left a sample of 850 @entity0 and @entity0 . Multivariable linear regression analyses were performed to assess associations among baseline values of leucocyte count and levels of acute-phase proteins (high-sensitivity C-reactive protein [hsCRP], @entity8 [ @entity8 ] and @entity6 ), @entity4 and @entity5 with changes in @entity7 c between baseline and follow-up. RESULTS: A high leucocyte count and high hsCRP, @entity8 and @entity4 levels were positively associated with changes in @entity7 c after adjusting for age, sex, lifestyle factors and baseline HbA1c. In contrast, the @entity5 level was inversely associated with changes in HbA1c (p value between <0.0001 and 0.020). The associations of leucocyte count and levels of hsCRP and @entity8 with HbA1c changes remained significant after additional adjustment for waist circumference and circulating lipids at baseline and for the 7  year change in waist circumference (p value between 0.004 and 0.045). CONCLUSIONS/INTERPRETATION: An elevated leucocyte count and elevated hsCRP and @entity8 were associated with early deterioration of glycaemia before the diagnosis of @entity3 2 @entity1 . These associations were largely independent of baseline abdominal adiposity and increases in waist circumference.

title: Association of subclinical XXXX with deterioration of glycaemia before the diagnosis of @entity3 2 @entity1 : the KORA S4/F4 study.

answer: @entity2


abstract: In @entity1 airways, @entity3 induced by @entity10 or antigen are thought to be mediated primarily by an action of the agonist or of released mast cell-derived mediators directly on the airway smooth muscle cell. An indirect contractile action mediated by endogenous @entity7 also has been described for both of these stimuli. The present study evaluated the contribution of endogenous @entity7 to ovalbumin- and leukotriene D4-induced @entity3 in the @entity1 bronchus by modulating the concentrations of @entity7 within the tissues and by using neurokinin receptor antagonists. Acute depletion of @entity7 with @entity4 had no effect on responses elicited by either stimulus. Similarly, @entity2 treatment failed to influence leukotriene D4-induced @entity3 . Inhibitors of neutral endopeptidase (thiorphan) and angiotensin-converting enzyme ( @entity5 ) enhanced neurally mediated tachykininergic responses and potentiated leukotriene D4. The latter effect persisted in the presence of @entity2 or the neurokinin antagonists @entity9 and @entity11 and in tissues treated acutely with @entity4 . The potentiation was absent, however, from bronchi incubated with @entity0 . Ovalbumin-induced @entity3 were unaltered by inhibition of neutral endopeptidase and angiotensin-converting enzyme. These observations suggest that @entity7 are not involved in mediation of leukotriene D4- or antigen-induced @entity3 of the @entity1 bronchus. The ability of protease inhibitors to potentiate leukotriene D4 but not antigen-induced responses is therefore ascribed to inhibition of bioinactivation of @entity6 D4 to @entity8 .

title: Absence of @entity7 involvement in leukotriene D4 and antigen-induced contraction of XXXX isolated bronchus.

answer: @entity1


abstract: UNASSIGNED: We have previously developed a multigene expression model of @entity1 @entity7 ( @entity7 ) with clinical validation in multiple cohorts and disease sites. We hypothesized @entity7 would identify @entity3 @entity0 who would respond to radiation and predict treatment outcomes. Clinical and array based gene expression (Affymetrix HT @entity0 Genome U133 Array Plate Set) level 2 data was downloaded from the @entity1 (TCGA). A total of 270 @entity0 were identified for the analysis: 214 who underwent radiotherapy and @entity4 and 56 who did not undergo radiotherapy. Median follow-up for the entire cohort was 9.1 months (range: 0.04-92.2 months). @entity0 who did not receive radiotherapy were more likely to be older (p < 0.001) and of poorer performance status (p < 0.001). On multivariate analysis, @entity7 is an independent predictor of @entity5 (HR = 1.64, 95% CI 1.08-2.5; p = 0.02). Furthermore, on subset analysis, radiosensitive @entity0 had significantly improved @entity5 in the @entity0 with high @entity6 expression (unmethylated @entity6 ), 1 year @entity5 84.1% vs. 53.7% (p = 0.005). This observation held on MVA (HR = 1.94, 95% CI 1.19-3.31; p = 0.008), suggesting that @entity2 has a larger therapeutic impact in these @entity0 . In conclusion, @entity7 predicts for @entity5 in @entity3 . These data further confirm the value of @entity7 as a disease-site independent biomarker.

title: The XXXX index predicts for overall survival in @entity3 .

answer: @entity7


abstract: A 67-year-old @entity0 was referred to our hospital because of positive sputum cytology. Despite detailed examination, the malignant cell source remained elusive. Twenty months later, CT revealed two nodules in the right S1 and S10 regions which were resected. A year following the operation, gastoendoscopy showed a @entity3 . Total gastrectomy with lymph node dissection was performed. Histologically, this @entity0 was diagnosed with double primary @entity1 with @entity2 to the stomach. The @entity3 of the lung, stomach and @entity3 cells in the sputum showed the same immunoreactivities of @entity4 ( @entity4 ). In our institution, of 38 occult @entity1 encountered during the past 10 years, four (10.5%) occurred in the peripheral region. The presented four cases of @entity1 in the peripheral resion revealed bad prognosis, as three out of four @entity0 were dead within 24 months after surgery. All of the four cases showed @entity2 , though the size of the @entity3 was small. Careful follow-up, including monitoring for distant @entity2 , is necessary in radiologically occult peripheral @entity1 .

title: Peripherally located occult @entity1 with XXXX expression.

answer: @entity4


abstract: It has previously been shown that analysis of coronary morphology can separate unstable from @entity10 . An @entity6 with a @entity1 or irregular borders, or both, is very common in @entity0 who present with acute @entity8 , whereas it is rare in @entity0 with @entity10 . To extend these observations to @entity3 , the coronary morphology of 41 @entity0 with acute or recent @entity7 and nontotally occluded @entity7 vessels was studied. For all @entity0 , 27 (66%) of 41 @entity7 vessels contained this eccentric narrowing, whereas only 2 (11%) of 18 noninfarct vessels with narrowing of 50 to less than 100% had this lesion (p less than 0.001). In addition, a separate group of @entity0 with acute @entity3 who underwent intracoronary streptokinase infusion were also analyzed in similar fashion. Fourteen (61%) of 23 @entity7 vessels contained this lesion after streptokinase infusion compared with 1 (9%) of 11 noninfarct vessels with narrowing of 50 to less than 100% (p less than 0.01). Therefore, an @entity9 with a @entity1 or irregular borders, or both, is the most common morphologic feature on angiography in both acute and recent @entity7 as well as @entity8 . This lesion probably represents either a disrupted @entity5 or a partially occlusive or lysed @entity4 , or both. The predominance of this morphology in both @entity8 and acute @entity7 suggests a possible link between these two conditions. @entity8 and @entity3 may form a continuous spectrum with the clinical outcome dependent on the subsequent change in coronary supply relative to @entity2 .

title: Coronary angiographic morphology in @entity3 : a link between the pathogenesis of @entity8 and XXXX .

answer: @entity3


abstract: OBJECTIVES: To characterize the responsiveness of the Montr  al Rehabilitation Performance Profile (MRPP); to measure the differential effectiveness of a @entity2 ( @entity2 ) and a task-nonspecific (TNS) motor learning format to promote alternating stair descent in @entity0 with @entity1 ; and to evaluate the relevance of the MRPP to evidence-based practice. DESIGN: Randomized comparison of 2 age-matched groups; psychometric testing of measurement tool. SETTING: School for @entity0 with developmental and @entity1 . @entity0 : Ambulatory sample of convenience: 18 @entity0 , age 5 to 9 years, with moderate to severe @entity1 . INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The MRPP variables measured at baseline; end of 10-week intervention; and 5 and 10 weeks postintervention. Analysis of variance for repeated measures and part-whole correlation. RESULTS: Global stair descent performance improved for both @entity2 and TNS groups over time (P=.001). However, a specific acquisition and retention of the alternating pattern of descent was associated with the @entity2 format. CONCLUSION: The MRPP was responsive to small differences in stair descent performance that are specific to the format of the motor learning intervention. The MRPP allows clinicians to determine the timing of the intervention needed to maintain or improve stair descent ability.

title: The Montr  al Rehabilitation Performance Profile: a statistical model for assessing stair descent in XXXX with @entity1 .

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity2 ) and its main binding protein ( @entity3 ) in blood have been associated with the risk of several types of @entity0 . However, epidemiological studies have inconsistent results regarding the association of circulating @entity2 / @entity3 levels with @entity1 risk. A systematic review of the prospective studies was conducted using meta-analysis to evaluate the existing evidence. Pubmed and Embase databases were searched to identify the relevant studies published before @entity4 , 2014. Four highly qualified studies with a total of 627 cases and 1,358 controls were finally included in the meta-analysis. Random effects meta-analysis was conducted by combining study-specific odds ratios (ORs) of @entity1 for the highest verses lowest exposure levels. A dose-response association was further assessed by relating the log of ORs for different exposure levels. As a result, the pooled ORs for the highest verses lowest categories of @entity2 / @entity3 were 0.85 [95% confidence interval (CI), 0.51-1.40]/0.78 (95% CI, 0.43-1.40). In the subgroup analyses, the pooled ORs of @entity2 / @entity3 were 1.89 (95% CI, 0.64-5.59)/1.08 (95% CI, 0.50-2.32) for the subgroup with cases diagnosed at <55 years, and 0.74 (95% CI, 0.50-1.08)/0.98 (95% CI, 0.73-1.33) for the subgroup with cases diagnosed at >= 55 years. No linear association between circulating @entity2 / @entity3 levels and @entity1 risk was identified. As no significant association of @entity2 / @entity3 with @entity1 risk was identified in the present meta-analysis of existing studies, more studies with greater quality are required in the future.

title: @entity3 with the risk of XXXX : A systematic review and meta-analysis.

answer: @entity1


abstract: UNASSIGNED: @entity0 who have undergone SOT mount a lower immune response after vaccination with TIV compared to healthy controls. @entity2 or SD TIV in pediatric SOT was given to subjects 3-17  yr and at least six  months post-transplant. Subjects were randomized 2:1 to receive either the @entity2 (60   g) or the SD (15   g) TIV. Local and systemic reactions were solicited after each vaccination, and immune responses were measured before and after each vaccination. Thirty-eight subjects were enrolled. Mean age was 11.25  yr; 68% male, 45% renal, 26% heart, 21% liver, 5% lung, and 5% intestinal. Twenty-three subjects were given @entity2 and 15 SD TIV. The median time since transplant receipt was 2.2  yr. No severe AEs or rejection was attributed to vaccination. The @entity2 group reported more @entity1 and local reactions, fatigue, and body ache when compared to the SD cohort, but these were considered mild and resolved within three  days. Subjects in the @entity2 group demonstrated a higher percentage of four-fold titer rise to H3N2 compared to the SD group. @entity2 influenza vaccine was well tolerated and may have increased immunogenicity. A phase 2 trial is needed to confirm.

title: Randomized, double-blind comparison of standard-dose vs. high-dose trivalent inactivated influenza vaccine in pediatric solid organ transplant XXXX .

answer: @entity0


abstract: Accurate and early diagnosis and appropriate treatment of @entity0 with @entity2 ( @entity2 ) are essential for the prevention or restriction of permanent @entity1 in @entity0 . The aim of this study was to compare renal ultrasonography (US) and @entity4 ( @entity4 ) renal scan in the diagnosis of @entity0 with febrile @entity2 . This study involved the medical records of @entity0 with febrile @entity2 who were admitted to the @entity0 's hospital in Qazvin, Iran. @entity3 was diagnosed on the basis of clinical symptoms, laboratory tests and abnormal @entity4 renal scans. The criteria for abnormality of renal US were an increase or a decrease in diffuse or focal parenchymal echogenicity, loss of @entity1 irregularities, parenchymal reduction and increased kidney size. Of the 100 study @entity0 , 23% had an abnormal US and 46% had an abnormal @entity4 renal scan. Of the latter @entity0 , 15 had concurrent abnormal US (P value  <= 0.03, concordance rate: 18%). Renal US had a sensitivity of 32%, specificity of 85%, positive predictive value of 65% and negative predictive value of 60%. Of the 77 @entity0 with normal US, 31 (40.2%) had an abnormal @entity4 renal scan. Despite the benefits and accessibility of renal US, its value in the diagnosis of @entity3 is limited.

title: Comparison of renal ultrasonography and XXXX renal scintigraphy in febrile @entity2 .

answer: @entity4


abstract: OBJECTIVE: To explore the diagnosis, treatment and prognosis of testicular @entity2 in @entity0 . METHODS: The clinical data of 37 @entity0 (aged between 3 months to 12 years) with @entity2 treated in our center between August 2000 and August 2013 were retrospectively analyzed. The median age was 14 months and 21 @entity0 were less than 2 years old. The @entity2 were on the left side in 18 cases, on the right side in 15 cases, and on both sides in 4 cases ( @entity3 ). Thirty-five @entity0 presented with painless scrotal mass; in the other two cases, @entity3 was found in routine medical examination in one case and testicular mature @entity4 was found due to perineal @entity5 in the other; both of the @entity0 underwent ultrasound or CT examination. Thirty-three @entity0 had @entity2 marker detection. Of the 37 @entity0 with benign @entity2 , 25 underwent radical inguinal orchiectomy and 12 had testis-sparing surgery. RESULTS: The @entity0 were followed up for 3-107 months (median 46 months). No @entity0 were found to have @entity2 recurrence, @entity1 or such complications as @entity7 ; 3 @entity0 had natural fertility later in adutthood. CONCLUSIONS: A high proportion of @entity2 in @entity0 are benign. Preoperative ultrasound or CT combined with detection of @entity2 markers such as serum @entity6 can be important in the diagnosis of pediatric @entity2 , for which testis-sparing surgery should be considered.

title: [Clinical analysis of pediatric testicular XXXX ].

answer: @entity2


abstract: OBJECTIVE: Atypical neuroleptics, including @entity3 , are used to treat @entity0 with @entity4 , despite limited efficacy and safety data. Many clinicians believe that @entity3 will not induce @entity1 in @entity0 . The authors investigated open @entity3 treatment in @entity0 with @entity4 and included findings on @entity1 . METHOD: The sample included 22 outpatients (mean age = 7.1 years) diagnosed with @entity4 (DSM-IV). Treatment consisted of a 1-month short-term phase followed by a 6-month long-term phase. At the end of the long-term phase, drug was discontinued, and the need for further drug treatment and the occurrence of @entity1 were assessed. Measures included the Clinical Global Impressions (CGI), @entity0 's Psychiatric Rating Scale (CPRS), and the @entity1 Scale. RESULTS: The mean @entity3 dosage was 1.2 mg/day. Overall, the @entity0 had significant clinical improvement as assessed by the CPRS and CGI. Untoward effects included sedation, increased appetite, and @entity2 . Two of 13 (15.4%) @entity0 treated long-term developed mild, reversible @entity1 when @entity3 was discontinued. No @entity0 developed @entity1 on @entity3 . CONCLUSIONS: @entity3 shows promise as a treatment in @entity4 . However, @entity1 were noted. Further assessment of the risk of @entity3 -related @entity1 is indicated.

title: XXXX treatment in @entity0 and adolescents with @entity4 : short- and long-term safety and effectiveness.

answer: @entity3


abstract: INTRODUCTION: We report the case of a Caribbean @entity0 with an atypical presentation of bilateral @entity6 . @entity0 AND METHODS: A 57-year-old @entity0 , with @entity3 and @entity10 , was referred to our center for a @entity7 in the right eye to hand motions. Ophthalmic examination revealed only right @entity9 . Brain magnetic resonance imaging was normal. Laboratory examination revealed no signs of @entity1 . A right non-arteritic acute @entity11 was first suspected. One week later, the visual acuity (VA) in the left eye dropped from 10/10 to 5/10 with the appearance of @entity9 on fundoscopic exam. This bilaterality led us to begin intravenous @entity5 followed by transition to oral. This improved the left eye VA to 10/10. Numerous bilateral white patches in the posterior pole appeared secondarily, hypofluorescent in the intermediate and late phases of angiography. RESULTS: The research of the etiology of @entity8 showed a positive tuberculin skin test without any prior vaccination. The vitreous humor sample was negative on direct examination, by culture and by polymerase chain reaction (PCR). DISCUSSION: Systemic corticosteroid therapy for @entity12 is not well described. It may theoretically treat the inflammatory portion of the lesions due to @entity2 as in meningeal and pericardial involvement. CONCLUSION: The clinical spectrum of @entity12 is wide and the diagnosis should be considered in any intraocular inflammatory condition of a chronic or acute recurrent nature, whether or not responsive to @entity4 .

title: Steroid treatment in XXXX : A double-edged sword?

answer: @entity12


abstract: The supply of islet cells is a limiting factor for the widespread application of islet transplantation of type-1 @entity1 . Islets constitute 1% to 2% of pancreatic tissue, leaving approximately 98% as discard after islet isolation and purification. In this report we present our data on the isolation of multipotent progenitor cells from discarded adult @entity0 pancreatic tissue. The collected cells from discarded nonislet fractions, after enzymatic digestion and gradient purification of islets, were dissociated for suspension culture in a serum-free medium. The cell clusters grown to a size of 100 to 150 mum contained cells staining for stage-specific embryonic antigens, but not insulin or @entity3 . To direct cell differentiation toward islets, clusters were recultured in a pancreatic differentiation medium. Insulin and @entity3 -positive cells by immunocytochemistry appeared within a week, reaching over 10% of the cell population. Glucagon and somatostatin-positive cells were also detected. The cell clusters were found to secrete insulin in response to @entity2 stimulation. Cells from the same clusters also had the capacity for differentiation into neural cells, as documented by staining for neural and glial cell markers when cultured as monolayers in media containing neurotrophic factors. These data suggest that multipotent pancreatic progenitor cells exist within the @entity0 pancreatic tissue that is typically discarded during islet isolation procedures. These adult progenitor cells can be successfully differentiated into insulin-producing cells, and thus they have the potential for treatment of @entity1 .

title: Multipotent progenitor cells isolated from adult XXXX pancreatic tissue.

answer: @entity0


abstract: BACKGROUND: Little is known concerning Hispanic @entity0 ' perceptions about the role of the physician in @entity1 management. This study seeks to describe the perspectives of Hispanic @entity0 toward @entity2 , and what they believe their doctor's role should be in the management of @entity1 . METHODS: A cross-sectional study utilizing semi-structured interviews was conducted in a university-based family medicine clinic. Open-ended questions explored beliefs about the relationship between weight and health, previous @entity2 experience, perceptions about the role of the physician in @entity2 , past experiences with their physician, and preferences for how a physician could help facilitate @entity2 . The free recall listing technique was used to elicit responses. Common themes were identified by a group coding process. RESULTS: @entity0 were open to discussion from physicians concerning @entity2 but many had not been approached. They wanted assistance from their doctors in the form of dietician referrals, specific @entity2 goals, and encouragement. @entity0 ' knowledge about the implications of excess weight on health was lacking. CONCLUSION: Hispanic @entity0 want more help and advice from their doctors. General knowledge of the health implications of @entity1 was lacking, indicating a need for more health education by the healthcare team.

title: Hispanic XXXX Perspectives of the Physician's Role in Obesity Management.

answer: @entity0


abstract: Opitz (or G/BBB) syndrome is a @entity1 characterized by @entity6 , @entity3 , and additional midline defects. This syndrome is heterogeneous with an X-linked ( @entity4 ) and an autosomal dominant (ADOS) form. The gene implicated in the @entity4 form, @entity7 , encodes a protein containing a RING-Bbox-Coiled-coil motif belonging to the tripartite motif (TRIM) family. To further clarify the molecular basis of @entity4 , we have undertaken mutation analysis of the @entity7 gene in @entity0 with @entity4 ( @entity4 ). We found novel mutations in 11 of 63 male individuals referred to us as sporadic or @entity4 cases. The mutations are scattered throughout the gene, although more are represented in the 3' region. By reviewing all the @entity7 -mutated @entity4 @entity0 so far described, we confirmed that @entity6 and @entity3 are the most frequent manifestations, being present in almost every @entity4 individual. However, it is clear that laryngo-tracheo-esophageal (LTE) defects are also common anomalies, being manifested by all @entity7 -mutated male @entity0 . Congenital heart and @entity2 are less frequent than reported in literature. In addition, we can include @entity5 in the @entity4 clinical synopsis as we found a @entity7 -mutated @entity0 showing syndactyly. The low frequency of mutations in @entity7 and the high variability of the phenotype suggest the involvement of other genes in the @entity4 phenotype.

title: X-linked Opitz syndrome: novel mutations in the XXXX gene and redefinition of the clinical spectrum.

answer: @entity7


abstract: OBJECTIVE: We reviewed the Mayo Clinic experience with management and outcome of @entity1 ( @entity1 ). METHODS: Retrospective review of charts for 306 @entity0 with true visceral @entity3 diagnosed from 1980 to 1998 enabled identification of 36 @entity0 (12%) with @entity1 . RESULTS: @entity0 with @entity1 included 23 @entity0 and 13 @entity0 , with mean age of 62.2 years (range, 20-85 years). Most @entity3 were extrahepatic (78%) and single (92%). Mean @entity3 diameter at presentation was 3.6 cm (range, 1.5-14 cm). Five @entity3 had @entity2 (14%), and four were symptomatic (11%). Mortality from @entity2 was 40%. Of the 9 @entity0 with @entity2 or symptomatic @entity3 , 2 @entity0 had multiple @entity1 , 3 @entity0 had @entity5 , and 2 @entity0 had @entity4 nodosa. All five HAAs that @entity2 were of nonatherosclerotic origin (P =.001). Fourteen @entity0 (39%) underwent elective procedures, including excision with vein graft (n = 7), excision with dacron graft (n = 3), excision alone (n = 2), and percutaneous embolization (n = 2). Two vein grafts and one dacron graft became occluded within 1 year. Nonoperative management was elected in 22 @entity0 (61%) with mean @entity3 diameter 2.3 cm (range, 1.5-5 cm). No complications related to the @entity3 occurred during mean follow-up of 68.4 months (range, 1-372 months). @entity3 growth was identified in 27%, the greatest being 0.8 cm over 34 months. CONCLUSIONS: @entity1 are at definite risk for @entity2 (14%). Risk factors for @entity2 include multiple @entity1 and nonatherosclerotic origin. @entity0 with symptomatic @entity3 or any of these risk factors should be considered for intervention.

title: XXXX : factors that predict complications.

answer: @entity1