abstract: Increased accumulation of lipoproteins and @entity0 within cells from regenerated endothelium may be responsible for their reported dysfunction. This study compared the presence and uptake of oxidized forms of low-density lipoprotein (LDL) in cells derived from native and regenerated endothelium. Four weeks after balloon denudation, primary cultures of native and regenerated endothelial cells were prepared from porcine coronary arteries. Regenerated endothelium stained more strongly using an antibody against oxidized lipoproteins. The increase in oxidized forms of @entity7 exhibited by cells from regenerated endothelium was not due to an increase in extracellular-induced oxidation of native LDL, measured as the production of @entity3 -reactive substances, being identical in both cell types. Intracellular @entity0 and @entity6 content were unchanged in regenerated cells. Using flow cytometry, accumulation of oxidized LDL was investigated further by quantifying the uptake of a mildly oxidized preparation of @entity5 -labelled LDL. The parameters of uptake, EC(50) and E(max), were not different between cells from native and regenerated endothelium suggesting that the number of @entity8 receptors was identical in the two cell types. Moreover, a negative correlation between the increased uptake of acetylated LDL and decreased @entity4 production in response to @entity2 was observed in cells from regenerated endothelium. Thus, the increased incorporation of modified LDL and their intracellular oxidation could be responsible for the alteration in NO production. The presence of oxidized forms of LDL may be a marker of endothelium regeneration and could be involved in the endothelial dysfunction of @entity1 coronary arteries 4 weeks after balloon denudation.

title: Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of XXXX without a modification in the uptake of oxidized LDL.

answer: @entity7


abstract: BACKGROUND: This multicentre, randomised, double-blind, placebo-controlled trial was performed to determine whether the use of oral probiotic preparation (prOVag  ) containing three Lactobacillus strains together with standard @entity1 treatment and also targeted antibiotic treatment (following the failure of @entity1 therapy) could reduce the recurrence rates of @entity2 (AV). METHODS: @entity0 at private gynaecological clinics in Poland with histories of recurrent BV/AV and current symptoms were randomly allocated to receive @entity1 and probiotic or placebo, and assessed monthly on visits II and III-V. The total number of study visits was 5-6 (I, II, II bis - if applicable, III, IV, V). One probiotic or placebo capsule was administered with @entity1 /targeted antibiotic twice daily for 10  days; during follow up, @entity0 took one capsule daily for 10  days perimenstrually. Clinical examination and vaginal swabbing were performed at each visit. Primary outcomes were clinical or microbiological BV/AV recurrence and probiotic safety. Secondary outcomes were vaginal pH, Nugent score, and Lactobacillus counts in the vaginal microbiota. Safety analysis was performed in 578 (probiotic, n   =   285; placebo, n   =   293) 18-50-year-old @entity0 who were randomised. RESULTS: BV/AV was confirmed microbiologically in 241 (probiotic, n   =   118; placebo, n   =   123) @entity0 , who continued the trial. Data from 154 (probiotic, n   =   73; placebo, n   =   81) @entity0 who completed the study were analysed to determine the efficacy of prOVag. Additional analyses included 37 (probiotic, n   =   22; placebo, n   =   15) @entity0 who received targeted antibiotics and probiotics or placebo. prOVag lengthened the time to clinical relapse of BV/AV symptoms up to 51  % (p   <   0.05) compared with placebo; AV relapse was delayed by up to 76  % (p   <   0.05). Probiotic use also reduced and maintained low vaginal pH and Nugent score, and increased vaginal Lactobacillus counts following standard treatment. CONCLUSION: This study demonstrated that oral probiotics lengthened remission in @entity0 with recurrent BV/AV and improved clinical and microbiological parameters. TRIAL REGISTRATION: NCT01993524 ; 20 November 2013.

title: Supplementation of standard antibiotic therapy with oral probiotics for XXXX : a randomised, double-blind, placebo-controlled trial.

answer: @entity2


abstract: OBJECTIVES: To minimize any residual false lumen when operating on @entity0 with an acute @entity3 aortic dissection, we tried to perform extensive primary repair of the thoracic aorta with the modified @entity4 trunk technique. The early and midterm results of these surgical interventions are reported and evaluated. METHODS: Among the acute @entity3 aortic dissections with extensive false lumen encountered since December 1997, 19 consecutive @entity0 , 15 DeBakey type I with the tear in the ascending, transverse, or both aortas, and 4 DeBakey type III-D with the tear located in the descending aorta, underwent insertion of a synthetic graft with a distally anchored stent in the descending thoracic aorta. The interpolation method was used as an introducer combined with total replacement of the aortic arch by using a synthetic branching graft with only a median sternotomy. RESULTS: One @entity0 died, and 18 were discharged after full recovery. Postoperative computed tomographic scans showed that no residual false lumina were present proximal to the diaphragmatic level, and no false lumina were found in 10 @entity0 . Two @entity0 with acute @entity1 of the right kidney caused by narrowing of the true lumen, as demonstrated by radiographic computed tomography, improved significantly after surgical intervention with restoration of blood flow in the true lumen. @entity2 was not observed in any @entity0 . CONCLUSIONS: In emergency operations for an acute @entity3 aortic dissection, the operation is often limited to replacing the ascending aorta because priority is given to saving the @entity0 's life. However, it is possible to perform extensive primary repair of the thoracic aorta with relative safety by interpolating a synthetic graft with a self-expandable stent.

title: Extensive primary repair of the thoracic aorta in Stanford XXXX acute aortic dissection by means of a synthetic vascular graft with a self-expandable stent.

answer: @entity3


abstract: BACKGROUND: We tested the hypothesis that the steady and pulsatile components of blood pressure (BP) exert a different influence on @entity6 and @entity2 in subjects with @entity3 . METHODS AND RESULTS: We analyzed data on 2311 subjects with essential @entity3 . All subjects (mean age 51 years, 47% @entity0 ) underwent off-therapy 24-hour ambulatory BP monitoring. Over a follow-up period of up to 14 years (mean 4.7 years), there were 132 major @entity5 (1.20 per 100 @entity0 -years) and 105 cerebrovascular events (0.90 per 100 @entity0 -years). After adjustment for age, sex, @entity1 , serum @entity4 , and cigarette smoking (all P<0.01), for each 10 mm Hg increase in 24-hour pulse pressure (PP), there was an independent 35% increase in the risk of @entity5 (95% CI 17% to 55%). Twenty-four-hour mean BP was not a significant predictor of @entity5 after controlling for PP. After adjustment for age, sex, and @entity1 (all P<0.05), for every 10 mm Hg increase in 24-hour mean BP, the risk of cerebrovascular events increased by 42% (95% CI 19% to 69%), and 24-hour PP did not yield significance after controlling for 24-hour mean BP. Twenty-four-hour PP was also an independent predictor of fatal @entity5 , and 24-hour mean BP was an independent predictor of fatal cerebrovascular events. CONCLUSIONS: In subjects with predominantly systolic and diastolic @entity3 , ambulatory mean BP and PP exert a different predictive effect on the @entity5 . Although PP is the dominant predictor of @entity5 , mean BP is the major independent predictor of cerebrovascular events.

title: Different prognostic impact of 24-hour mean blood pressure and pulse pressure on XXXX and @entity6 in essential @entity3 .

answer: @entity2


abstract: OBJECTIVE: To develop and evaluated a rapid multiplex-qPCR to identify fecal carriers of multi-drug resistant extra-intestinal pathogenic @entity1 clonal groups. METHODS: @entity0 presenting for transrectal prostate biopsy (TPB) at the San Diego Veterans Affairs Medical Center underwent rectal culture immediately prior to TPB. Rectal swabs were streaked @entity3 -supplemented (4 mg/L) MacConkey agar plates, identified, and susceptibility tested. The same swab was sent to the University of Washington for qPCR test (EST200) targeting two major MDR-ExPEC clonal groups - ST131 and ST69 that combined were expected to represent majority of @entity4 as well as @entity2 resistant @entity1 . We calculate test characteristics including the area under the receiver operative curve (AUC). RESULTS: We enrolled 104 @entity0 from 11/5/2013 to 6/10/2014. @entity4 -resistant @entity1 were cultured from 19.2% (20/104) of rectal swabs and 26% (27/104) of all swabs were positive for EST200 by PCR. The test characteristics comparing the EST200 to the culture-based detection of @entity4 -resistance were 75%, 86%, 94%, and 56%, respectively. The AUC was 0.84 for the EST200 to detect @entity4 resistance prior to TPB. CONCLUSIONS: Compared to the reference standard rectal culture, EST200 was able to detect majority of @entity4 resistant @entity1 on rectal swabs prior to prostate biopsy.

title: Rapid Identification of Rectal Multi-Drug Resistant XXXX Prior to Transrectal Prostate Biopsy.

answer: @entity1


abstract: @entity9 , caused by direct and continuous contact with @entity7 , is associated with @entity1 , @entity2 , periductal @entity3 , and the development of @entity5 . Hepatic stellate cells respond to @entity4 through production of proinflammatory mediators which drive fibrogenesis; however, their endogenous sources and pathophysiological roles in host cells were not determined. @entity8 ferritin heavy chain (CsFHC) was previously confirmed as a component of excretory/secretory products and exhibited a number of extrahepatic immunomodulatory properties in various diseases. In this study, we investigated the expression pattern and biological role of CsFHC in @entity8 . CsFHC was expressed throughout life stages of @entity8 . More importantly, we found that treatment of @entity0 hepatic stellate cell line LX-2 with CsFHC triggered the production of free radicals via time-dependent activation of NADPH oxidase, xanthine oxidase, and inducible nitric oxide synthase. The increase in free radicals substantially promoted the degradation of cytosolic IkBa and nuclear translocation of NF-kB subunits (p65 and p50). CsFHC-induced NF-kB activation was markedly attenuated by preincubation with specific inhibitors of corresponding free radical-producing enzyme or the antioxidant. In addition, CsFHC induced an increased expression level of proinflammatory cytokines, IL-1b and IL-6, in NF-kB-dependent manner. Our results indicate that CsFHC-triggered free radical-mediated NF-kB signaling is an important factor in the @entity2 caused by @entity8 @entity6 .

title: @entity7 ferritin heavy chain triggers free radicals and mediates XXXX signaling in @entity0 hepatic stellate cells.

answer: @entity2


abstract: BACKGROUND: There is no study of circumferential EMR in @entity0 with @entity2 containing early stage malignant lesions. This study investigated the effectiveness and safety of circumferential EMR by using a simple snare technique without cap. METHOD: @entity0 with @entity2 containing multifocal high-grade intraepithelial @entity1 or @entity1 , and @entity0 with endoscopically nonidentifiable early stage malignant mucosal changes incidentally detected in random biopsy specimens were included in the study. A 30 x 50-mm polypectomy snare made of monofilament 0.4-mm steel wire was used without any additional device or submucosal injection. RESULTS: Twelve @entity0 (10 @entity0 , 2 @entity0 ; median age 63.5 years, range 43-88 years) underwent circumferential EMR; 5 had multifocal lesions, and 7 had no visible lesions. Segments of Barrett's epithelium were circumferential (median length 5 cm) and completely removed. The median number of EMR sessions was 2.5. The median number of snare resections per EMR session was 5. The medial total area of mucosa in resected specimens per session was 3.8 cm(2). Two @entity0 developed strictures that were successfully treated by bougienage. Minor @entity3 occurred during 4 of 31 EMR sessions. During a median follow-up of 9 months, no recurrence of @entity2 or @entity1 was observed. CONCLUSIONS: Circumferential EMR with a simple snare technique is feasible, safe, and effective for complete removal of Barrett's epithelium with early stage malignant changes.

title: Circumferential EMR and complete removal of Barrett's epithelium: a new approach to management of @entity2 containing high-grade intraepithelial XXXX and intramucosal carcinoma.

answer: @entity1


abstract: BACKGROUND: In contrast to adult hepatocytes, @entity4 ( @entity4 ) are thought to be highly proliferative, less immunogenic, and resistant to cryopreservation and @entity1 . These qualities could enhance @entity4 engraftment, proliferation, and gene transfer requiring active DNA synthesis. METHODS: @entity0 @entity4 were obtained using the nonperfusion collagenase/DNase digestion method. Free and cultured cells were studied using electron microscopy, fluorescence-activated cell sorting, and Northern analysis using @entity5 and albumin as markers of hepatocyte lineage. DNA synthetic activity was measured in quiescent and mitogen-stimulated fetal and adult hepatocytes by @entity3 incorporation. Susceptibility of cultured @entity4 to retrovirally mediated gene transfer was studied using an amphotropic retroviral vector carrying the @entity2 lac-Z gene. Nagase analbuminemic @entity0 were used as recipients to study the effects of intraportal @entity4 transplantation. Analysis of serum albumin was carried out by enzyme-linked immunosorbent assay. RESULTS: In fetal liver, 87+/-2% of the cells showed morphological and molecular features of hepatocytes. DNA synthetic activity in nonstimulated cultured @entity4 was 10 times greater than the maximal hepatocyte growth factor-driven response in adult @entity0 hepatocytes. A total of 5-15% @entity4 stained positive for X-gal; results of transduction in adult hepatocyte cultures were negative. In Nagase analbuminemic @entity0 recipients, @entity4 produced significant amounts of albumin only when a hepatic regenerative stimulus was applied. Immunohistochemistry confirmed presence of albumin-positive hepatocytes. CONCLUSIONS: Fetal @entity0 liver from the late gestation period is highly enriched with hepatocyte progenitors. They are highly proliferative and susceptible to retroviral transduction and can engraft and function in the adult @entity0 liver if transplanted under a hepatic regenerative stimulus.

title: Fetal XXXX hepatocytes: isolation, characterization, and transplantation in the Nagase analbuminemic @entity0 .

answer: @entity0


abstract: PURPOSE: To evaluate the survival benefit of adjuvant chemotherapy after curative resection in serosa-negative @entity3 @entity0 (excluding @entity0 who were T1N0), we conducted a multicenter phase III clinical trial in which 13 @entity1 centers in Japan participated. @entity0 AND METHODS: From January 1993 to December 1994, 252 @entity0 were enrolled into the study and allocated randomly to adjuvant chemotherapy or surgery alone. The chemotherapy comprised intravenous mitomycin 1.33 mg/m2, @entity4 (FU) 166.7 mg/m2, and @entity5 13.3 mg/m2 twice weekly for the first 3 weeks after surgery, and oral FU 134 mg/m2 daily for the next 18 months for a total dose of 67 g/m2. The primary end point was relapse-free survival. Overall survival and the site of recurrence were secondary end points. RESULTS: Ninety-eight percent of @entity0 underwent gastrectomy with D2 or greater lymph node dissection. There were no treatment-related @entity2 and few serious adverse events. There was no significant difference in relapse-free and overall survival between the arms (5-year relapse-free survival 88.8% chemotherapy v 83.7% surgery alone; P =.14 and 5-year survival 91.2% chemotherapy v 86.1% surgery alone; P =.13, respectively). Nine @entity0 (7.1%) in the chemotherapy arm and 17 @entity0 (13.8%) in the surgery-alone arm had @entity1 recurrence. CONCLUSION: There was no statistically significant relapse-free or overall survival benefit with this adjuvant chemotherapy for @entity0 with macroscopically serosa-negative @entity3 after curative resection, and there was no statistical difference between the two arms relating to the types of @entity1 recurrence. We do not recommend adjuvant chemotherapy with this regimen for this population in clinical practice.

title: Randomized trial of adjuvant chemotherapy with mitomycin, @entity4 , and @entity5 followed by oral @entity4 in serosa-negative XXXX : Japan Clinical Oncology Group 9206-1.

answer: @entity3


abstract: OBJECTIVE: To investigate the effects of @entity5 on chondrocytes cultured with or without @entity3 . DESIGN: @entity0 articular chondrocytes were cultured in three-dimensional (3-D) agarose constructs. Cells were distributed into each of the two groups, those without @entity3 and those with @entity3 added to the liquid media. Each group was subdivided into three groups, based on the presence of @entity5 . @entity3 and TIMPs were added to liquid media bathing the 3-D constructs beginning on day 3. The liquid media and the 3-D constructs were collected on days 9, 15, and 24, and analyzed histologically, biochemically, and immunohistochemically. RESULTS: Addition of @entity2 or -2 resulted in decreases in @entity4 concentrations of 37 and 41%, and @entity6 immunoreactivity of 32 and 36%, respectively, compared with the @entity3 group, on day 9. Chondrocytes in groups without @entity3 maintained viability and produced abundant extracellular matrix (ECM). Chondrocytes in @entity3 groups appeared less viable and produced less ECM compared with those without @entity3 . Glycosaminoglycan (GAG) concentrations in 3-D constructs (GAG/weight) were significantly (P<0.001) higher in groups without @entity3 than in those with @entity3 , on days 15 and 24. CONCLUSIONS: The addition of TIMP was not detrimental to chondrocytes, as used in this study. Despite evidence of decreased MMP levels, TIMPs did not prevent @entity3 -associated changes in cellular or ECM characteristics. Further study is necessary before clinically relevant conclusions can be drawn regarding the use of TIMPs in the treatment of @entity1 .

title: The effects of @entity5 on XXXX chondrocytes cultured in three-dimensional agarose culture system.

answer: @entity0


abstract: As a model for @entity2 ( @entity2 ), transgenic @entity4 ( @entity7 ) @entity0 constitute the standard tool for evaluating future therapeutic strategies. Due to axonal retraction from neuromuscular junctions, the animals suffer from @entity5 leading to weakness and @entity3 of the extremities, which in early stages can be detected by measuring @entity1 . Suspecting that underlying mechanisms might yield @entity6 ahead of @entity1 onset, we wanted to determine a behavioural test to detect disease onset time earlier. We compared the monitoring of weight with the "forced" examination of grip strength and the investigation of freely behaving animals within an open field. Additionally, we compared two different data analysis methods: (1) two-way ANOVA with Bonferroni correction (2) break point analysis calculating symptom onset time points for each animal. Break point analysis revealed onset times that significantly preceded those obtained by standard two-way ANOVA. Open field analysis of freely moving animals could not give an advantage over @entity1 measurements. Grip strength assessment of hindlimbs detected disease onset 36 days before the first evidence of @entity1 , providing a maximal treatment window of 84 days on average before the death of male animals. We conclude that grip strength analysis of hindlimbs is a very sensitive and reproducible motor behavioural test, which can even be applied to small cohorts of animals. Combined with break point analysis, it represents the method of choice to detect early disease onset in @entity4 ( @entity7 ) @entity0 .

title: Reassessment of motor-behavioural test analyses enables the detection of early disease-onset in a transgenic @entity0 model of XXXX .

answer: @entity2


abstract: OBJECTIVE: To study the clinical and immunological profile of @entity0 with @entity9 ( @entity9 ). DESIGN: Retrospective hospital based study. SETTING: Tertiary level center of North India. SUBJECTS: Sixteen @entity0 in the age group 4-12 years. METHODS: Medical records of @entity0 with @entity9 were analyzed. Clinico pathological features were compared with 2 other series from India. RESULTS: Mean age of @entity0 at the time of diagnosis was 10 yr and 8 (50%) @entity0 were less than 10 yr of age. The female to male ratio was 7:1. Fever (56.2%), @entity10 (87%) and @entity5 (87%) were the common clinical manifestations, Renal involvement was noted in 56.2% of cases. Other clinical features included @entity13 (31.2%), @entity7 (18.6%) and @entity12 (12.5%). Cardiac involvement in the form of severe @entity11 and @entity8 occurred in one @entity0 each. @entity3 was the presenting feature in one @entity0 with @entity6 . One @entity0 had @entity1 along with @entity9 --a rare combination. ANA positivity was seen in all @entity0 . Five @entity0 died; two had severe @entity4 . Three @entity0 had renal involvement and one died of @entity3 . Two-thirds of subjects with renal involvement improved after therapy according to NIH, Bethesda protocol. CONCLUSIONS: @entity9 must be considered in any @entity0 with @entity2 , as the disease may have certain unusual presentations.

title: Clinical and immunological profile of XXXX : some unusual features.

answer: @entity9


abstract: BACKGROUND: Psoriasis is a chronic, immune-mediated @entity5 associated with substantial economic, clinical, and humanistic burden. OBJECTIVE: The aim of this study was to understand the disutility of @entity0 with @entity9 , using mean baseline EuroQoL five dimensions (EQ-5D) index scores reported in the published literature, and to compare this to @entity0 with other @entity6 . METHODS: Two systematic literature searches were conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Searches were conducted in ten databases including Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL). The first search (December 2013) used search terms psoria* AND (EQ5D OR EQ OR EUROQoL). Only publications of original research, which reported baseline EQ-5D scores for mild/moderate/severe @entity9 , were included. The second search (March 2014) used the terms (systematic review) AND (EQ5D OR EQ 5D OR EuroQoL). Titles were screened by two independent reviewers. Four independent reviewers reviewed titles and full-length papers. EQ-5D scores for @entity9 @entity0 were qualitatively compared with scores from @entity0 with other @entity6 identified through the literature search. RESULTS: Of 133 publications on @entity9 , 12 met the inclusion criteria. The mean EQ-5D index scores for @entity9 (all severities) ranged from 0.52 (standard deviation: 0.39) to 0.9 (standard deviation: 0.1). Of the 48 results from the second search, six met the inclusion criteria. The reported EQ-5D lower limit for other diseases ranged from 0.20 ( @entity2 ) to 0.66 ( @entity8 ). The highest EQ-5D estimates for other diseases ranged from 0.79 ( @entity8 ) to 0.93 ( @entity1 @entity0 ). Both lower and upper EQ-5D estimates in @entity9 @entity0 were within the range of those reported for other @entity6 . CONCLUSION: Comparative studies of morbidity are relevant in health care studies and @entity0 advocacy. This systematic review demonstrates that the ranges of disutility among @entity9 @entity0 are within the ranges of other @entity6 ( @entity4 , @entity2 , end-stage @entity3 , @entity8 , @entity1 , and @entity7 ).

title: A systematic literature review to compare quality of life in @entity9 with other XXXX using EQ-5D-derived utility values.

answer: @entity6


abstract: UNASSIGNED: This study aimed to investigate the role of miRNAs in HPV-mediated cervical @entity1 and @entity1 cases in Indian population. We analysed the @entity3 and its genotypes in uterine cervical @entity1 (n   =   80), @entity1 (n   =   200) and normal cervical samples (n   =   150) by consensus sequence PCR followed by type specific PCRs. Also, microRNA profiling was done in a subset of cervical @entity1 (n   =   20), @entity1 cases (n   =   50) and normal samples (n   =   30) by real-time quantitative PCR (qRT-PCR). The prevalence of @entity3 in @entity1 was found to be 81  % (65/80) and 94  % (188/200) in @entity1 cases, with most predominant high-risk HPV @entity5 (HR- @entity5 ) in 83  % of @entity1 and 91  % of pre- @entity1 cases, respectively. Whereas in controls, the @entity3 was found to be very low (5  %). The miRNA profiling revealed that in cervical @entity1 , 100 miRNAs were significantly (p   <   0.001) differentially expressed with 70 miRNAs upregulated and 30 miRNAs downregulated. In @entity1 cases, 383 miRNA were found to be differentially expressed (p   <   0.001), of which 350 miRNAs were upregulated and 33 miRNAs were downregulated. We also observed that 182 miRNAs were differentially expressed (p   <   0.001) in @entity5 /18-positive ( @entity0 /HeLa) cell lines compared with HPV-negative ( @entity0 ) cell line. In addition, we identified the novel microRNAs such as @entity8 , @entity7 , @entity9 , @entity6 and @entity10 in cervical @entity4 and @entity1 cases in Indian population. Taken together, the study demonstrates a crucial role of microRNAs in @entity1 , which may serve as potential early diagnostic markers for cervical @entity2 .

title: Novel MicroRNA signatures in HPV-mediated cervical XXXX in Indian @entity0 .

answer: @entity2


abstract: PURPOSE: We investigated the surgical outcomes of clinical-T1b @entity5 @entity0 whose @entity2 had a solid-dominant radiological appearance and who were treated with segmentectomy or lobectomy. METHODS: We examined 154 surgically resected clinical-T1b @entity5 with a "solid-dominant" appearance on thin-section computed tomography (CT). The preoperative thin-section CT images of all cases were reviewed. "Solid-dominant" was defined as 0.5 <= consolidation/ @entity2 ratio (CTR) <1.0. RESULTS: Pathological nodal metastasis, lymphatic invasion, @entity4 , and @entity1 were found in 7 (4.5  %), 27 (18  %), 21 (14  %), and 15 (10  %) @entity0 with clinical-T1b solid-dominant @entity5 , respectively. Lobectomy and segmentectomy were performed in 123 (80  %) and 31 (20  %) cases, respectively. The 3-year @entity3 ( @entity3 ) and @entity6 ( @entity6 ) of @entity0 with clinical-T1b solid-dominant @entity5 were 95.5 and 92.4  %, respectively. The 3-year @entity6 and @entity3 did not differ significantly between the @entity0 who underwent lobectomy or segmentectomy (3-year @entity6 , 92.3 vs. 93.4  %, p  =  0.8713; 3-year @entity3 , 95.3 vs. 96.6  %, p  =  0.7603). Segmentectomy was not found to be a prognostic factor for @entity6 (p  =  0.8714), or @entity3 (p  =  0.7613). CONCLUSIONS: Segmentectomy can achieve acceptable oncological outcomes (both in terms of @entity3 and @entity6 ), which are similar to those achieved with standard lobectomy, in @entity0 with clinical-T1b solid-dominant @entity5 .

title: The oncological outcomes of segmentectomy in clinical-T1b XXXX with a solid-dominant appearance on thin-section computed tomography.

answer: @entity5


abstract: BACKGROUND AND AIM: @entity1 is one of the main cardiovascular risk factors in the elderly. The aims of this work were to evaluate if a one-year intervention with two Mediterranean diets (Med-diet) could decrease blood pressure (BP) due to a high @entity3 consumption, and if the decrease in BP was mediated by plasma @entity2 (NO) production. METHODS AND RESULTS: An intervention substudy of 200 @entity0 at high cardiovascular risk was carried out within the PREDIMED trial. They were randomly assigned to a low-fat control diet or to two Med-diets, one supplemented with extra virgin olive oil (Med-EVOO) and the other with nuts (Med-nuts). Anthropometrics and clinical parameters were measured at baseline and after one year of intervention, as well as BP, plasma NO and total @entity3 excretion (TPE) in urine samples. Systolic and diastolic BP decreased significantly after a one-year dietary intervention with Med-EVOO and Med-nuts. These changes were associated with a significant increase in TPE and plasma NO. Additionally, a significant positive correlation was observed between changes in urinary TPE, a biomarker of TP intake, and in plasma NO (Beta  =  4.84; 95% CI: 0.57-9.10). CONCLUSIONS: TPE in spot urine sample was positively correlated with plasma NO in Med-diets supplemented with either EVOO or nuts. The statistically significant increases in plasma NO were associated with a reduction in systolic and diastolic BP levels, adding to the growing evidence that @entity4 might protect the cardiovascular system by improving the endothelial function and enhancing endothelial synthesis of NO.

title: Effects of total dietary @entity4 on plasma XXXX and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial.

answer: @entity2


abstract: INTRODUCTION: @entity2 ( @entity2 ) system was designed to provide bone stability and to enhance bone healing. However, implant failure, nonunion and instability are still frequently encountered complications. The purpose of this study was to assess and compare the biomechanical characteristics of a novel @entity1 ( @entity1 ) with the commonly used @entity2 . MATERIALS AND METHODS: Twelve 4th generation composite artificial femoral bones were used. Transverse @entity0 was created in all bones, 6 femurs were fixated using the novel @entity1 , whereas the other 6 femurs were fixated using the traditional @entity2 . All samples had undergone a non-destructive repetitive different forces (axial compression, bending and torsion), to evaluate the biomechanical differences between the two plating systems. RESULTS: Under axial load the mean stiffness value was 439.0  N/mm for the @entity1 and 158.9  N/mm for the @entity2 , @entity1 showed a statistically significant stiffness value than @entity2 with a P value of 0.004. There was no significant difference in flexion/extension bending strain values between @entity1 and @entity2 . However @entity2 provided significantly stiffer fixation in medial and lateral bending tests than @entity1 (P  =  0.037) and (P  =  0.016) respectively. But no significant difference was detected between the two plating system in the applied torsional stress. CONCLUSION: These results do not show any significant biomechanical difference in the applied torsional and bending stresses between @entity2 and @entity1 . However the remarkably increased persistent compression effect of the @entity1 created a considerable stress on @entity0 edges which may accelerate bone healing.

title: A novel @entity1 for XXXX : An in vitro biomechanical study.

answer: @entity0


abstract: OBJECTIVE: To examine the audiometric patterns of @entity1 due to the @entity6 mutation in the mitochondrial DNA. @entity0 AND METHODS: We include 55 subjects with the @entity6 mutation from 6 unrelated families, affected by nonsyndromic @entity3 and residing in Cantabria. The @entity6 mutation was found in homoplasmy in all the families, except in one family, in which it was in heteroplasmy. Aside from standard history taking and general otolaryngological examination, pure tone audiometry was carried out in all @entity0 . RESULTS: @entity1 was developed by most of the @entity0 . The auditory defect was a slowly progressive bilateral symmetrical @entity3 , affecting mainly the high frequencies. In @entity0 in which @entity5 @entity4 could be excluded, @entity1 usually ranged from mild to moderate, with a late onset. In 17 cases there were previous history of treatment with a @entity4 drugs, and most of them developed severe @entity1 . One of them was deaf-mute. No audometric differences between families with the homoplasmic and the heteroplasmic @entity6 mutation were observed. CONCLUSIONS: @entity0 with the @entity6 mutation generally present bilateral symmetrical @entity3 , ranging from mild to moderate, slowly progressive, which is obvious approximately in the second decade of life and affects specially the high frequencies. @entity1 severity is increased by treatment with @entity2 .

title: [Audiometric features of @entity1 transmitted by mitochondrial inheritance ( XXXX )].

answer: @entity6


abstract: BACKGROUND: Epithelial growth factor receptor inhibitors (EGFRis) and bevacizumab ( @entity2 ) are used in combination with chemotherapy for the treatment of metastatic @entity0 (mCRC). However, few randomized controlled trials (RCTs) have directly compared their relative efficacy on progression-free survival (PFS) and @entity1 ( @entity1 ). METHODS: We conducted a systematic review of first-line RCTs comparing (1) EGFRis vs. @entity2 , with chemotherapy in both arms (2) EGFRis + chemotherapy vs. chemotherapy alone, or (3) @entity2 + chemotherapy vs. chemotherapy alone, using Cochrane methodology. Data on and PFS and @entity1 were extracted using the Parmar method. Pairwise meta-analyses and Bayesian network meta-analyses (NMA) were conducted to estimate the direct, indirect and combined PFS and @entity1 hazard ratios (HRs) comparing EGFRis to @entity2 . RESULTS: Seventeen RCTs contained extractable data for quantitative analysis. Combining direct and indirect data using an NMA did not show a statistical difference between EGFRis versus @entity2 (PFS HR = 1.11 (95% CR: 0.92-1.36) and @entity1 HR = 0.91 (95% CR: 0.75-1.09)). Direct meta-analysis (3 RCTs), indirect (14 RCTs) and combined (17 RCTs) NMA of PFS HRs were concordant and did not show a difference between EGFRis and @entity2 . Meta-analysis of @entity1 using direct evidence, largely influenced by one trial, showed an improvement with EGFRis therapy (HR = 0.79 (95% CR: 0.65-0.98)), while indirect and combined NMA of @entity1 did not show a difference between EGFRis and @entity2 Successive inclusions of trials over time in the combined NMA did not show superiority of EGFRis over @entity2 . CONCLUSIONS: Our findings did not support @entity1 or PFS benefits of EGFRis over @entity2 in first-line mCRC.

title: A Systematic Review and Network Meta-Analysis of Biologic Agents in the First Line Setting for Advanced XXXX .

answer: @entity0


abstract: Long non-coding RNAs (lncRNAs) are novel regulators in @entity0 biology. @entity2 -activated lncRNA ( @entity4 ) is overexpressed in @entity1 and has a potential functional role in @entity1 cell migration. However, little is known about the role of @entity4 in the development of @entity3 ( @entity3 ). In the present study, @entity4 expression was examined in six pairs of @entity3 and matched adjacent normal tissues. The results revealed that @entity4 levels were significantly higher in the @entity3 tissues and @entity3 IHH-4 cells compared with the normal controls. Knockdown of @entity4 in the IHH-4 cells inhibited proliferation and increased apoptosis of the cells in vitro. Further investigation of the underlying mechanisms revealed that @entity4 markedly activated autophagy. Overexpression of @entity4 inhibited apoptosis in the IHH-4 cells, whereas inhibition of autophagy stimulated apoptosis in the @entity4 -overexpressed cells. @entity4 overexpression also increased cell proliferation and the inhibition of autophagy abrogated @entity4 overexpression-induced cell proliferation. In addition, the overexpression of @entity4 resulted in an increase in the ratio of LC3-II/LC3-I, a marker for autophagy, while the knockdown of @entity4 decreased the ratio of LC3-II/LC3-I. These results revealed that @entity4 expression levels are upregulated in @entity3 . Additionally, @entity4 increases @entity3 cell proliferation, which could activate autophagy.

title: @entity2 -activated long non-coding RNA contributes to cell proliferation and activates autophagy in XXXX .

answer: @entity3


abstract: Long-standing intractable @entity3 are common manifestation of @entity4 . There is much controversy regarding the most appropriate surgical treatment (lesionectomy vs resection of the epileptogenic cortex with the lesion) for @entity0 with intractable @entity2 associated with @entity5 . We reported 2 cases, in which the favorable @entity3 outcome was obtained following lesionectomy alone. (Case 1) Nine-year-old female developed attack of abnormal sensation in her left upper limb followed by motor @entity3 in her left limbs since 5 years old. MRI revealed hyperintense @entity1 in the right medial frontal lobe. Chronic invasive subdural recording showed that ictal onset zone was located in the hand motor area. Following lesionectomy alone, she became free from @entity3 . (Case 2) Eight-year-old @entity0 had intractable generalized @entity3 since 6 years old. MRI revealed a @entity1 in the right parietal lobe. She had multiple spike foci on electroencephalography and magnetoencephalography, and intraoperative electrocorticography failed to reveal the paroxysm. Following lesionectomy, she had good relief with less than one minor @entity3 per 1-3 months. Thus, lesionectomy, even without resection of the epileptogenic cortex, may improve @entity3 outcome in @entity0 with @entity5 -associated @entity2 .

title: [Surgical management of intractable XXXX in @entity0 with @entity5 ].

answer: @entity2


abstract: MDA-MB-231, an HLA-A2(+), @entity5 /neu(+) allogeneic @entity0 cell line genetically modified to express the costimulatory molecule @entity7 (B7-1), was used to vaccinate 30 @entity1 with previously treated @entity0 . Expression of @entity7 conferred the ability to deliver a costimulatory signal and thereby improved the antigen presentation capability of the @entity2 cells to @entity1 T cells in vitro. @entity1 were vaccinated with 10(7) or 10(8) irradiated gene-modified @entity2 cells with @entity6 ( @entity6 ) or BCG, three times at 2-week intervals and then monthly until progressive disease developed. @entity6 -related flulike symptoms and minor injection site reactions were observed frequently. @entity4 stabilization was observed in four @entity1 but no objective @entity2 regressions were seen. Immune responses were measured in matched peripheral blood samples collected before and after treatment from 9 of 15 @entity1 treated at the 10(8) @entity2 cell dose. Four @entity1 exhibited MHC class I-restricted cytokine production in response to the @entity0 cell line. One @entity1 maintained an increased number of circulating @entity2 -specific, interferon gamma-secreting CD8(+) T cells for 24 months after the last vaccination. One @entity1 exhibited a @entity2 -specific @entity3 response to an @entity2 cell line. This immunization strategy proved to be safe and feasible, and induced @entity2 -specific immune responses in a minority of @entity1 ; however, no objective @entity2 regressions were observed.

title: Vaccination of @entity1 with metastatic @entity0 , using a costimulatory gene ( XXXX )-modified, HLA-A2-matched, allogeneic, @entity0 cell line: clinical and immunological results.

answer: @entity7


abstract: BACKGROUND: Three different therapeutic regimens of @entity5 ( @entity5 ) in combination with @entity4 ( @entity4 ) and @entity6 (FA) were evaluated for efficacy and safety in the first-line therapy of advanced @entity1 . @entity0 AND METHODS: @entity0 were randomly assigned to receive intravenously either: @entity5 125 mg/m(2), FA 20 mg/m(2) followed by @entity4 500 mg/m(2) bolus, weekly for 4 weeks (arm A, Saltz regimen); or @entity5 180 mg/m(2) day 1 then FA 200 mg/m(2) over 2 h and @entity4 400 mg/m(2) bolus and @entity4 600 mg/m(2) 22-h infusion on days 1 and 2, every 2 weeks (arm B, Douillard regimen); or @entity5 350 mg/m(2) (days 1 and 43) alternating with FA 20 mg/m(2)/day followed by @entity4 bolus 425 mg/m(2)/day during 5 days (days 22-26) (arm C, Mayo Clinic regimen). RESULTS: A total of 154 @entity0 were included in the study (arm A, 51 @entity0 ; arm B, 53; arm C, 50). Overall response rates for the intention-to-treat populations were 33% [95% confidence interval (CI) 21% to 48%], 42% (95% CI 28% to 56%) and 30% (95% CI 18% to 45%) for arms A, B and C, respectively. Median times to progression were 6, 8 and 7 months for arms A, B and C, respectively. Median survival times were 15, 12 and 17 months for arms A, B and C, respectively. Overall response rates for the evaluable @entity0 populations were 40% (95% CI 24% to 58%) in arm A, 44% (95% CI 29% to 60%) in arm B and 31% (95% CI 17% to 47%) in arm C. @entity3 was the main serious adverse event in arms A (30% of @entity0 ) and C (22% of @entity0 ) but occurred in only 8% of @entity0 in arm B. Delayed @entity2 was the main severe adverse event for the three regimens, from 15% to 22%. CONCLUSION: All three regimens were highly active. The biweekly combination of @entity5 and @entity4 /FA (arm B) was notable for its low incidence of grade 3/4 @entity3 . The incidence of grade 3/4 delayed @entity2 was equivalent for the three treatment arms.

title: A randomized phase II trial of @entity5 in combination with infusional or two different bolus @entity4 and XXXX regimens as first-line therapy for advanced @entity1 .

answer: @entity6


abstract: OBJECTIVES: We evaluated the postoperative @entity3 after @entity4 ( @entity4 ) surgery and analyzed factors causing it. MATERIAL AND METHODS: We included 89 consecutive @entity0 undergoing surgical excision of unilateral @entity4 . @entity0 and @entity1 characteristics, surgical approaches, @entity3 , extent of @entity1 resection and complications were analyzed. RESULTS: Complete @entity1 resection was achieved in 85% of cases. Anatomic preservation of the facial nerve was achieved in 96% of @entity0 . In all @entity1 stages, 88.2% of @entity0 , have a normal or subnormal facial function within one year of the intervention, the rate was 100% in @entity0 carrying a @entity4 stage I or II. No severe complication or @entity2 was reported. CONCLUSION: Short- and long-term facial nerve outcome was comparable with results of other recent series reported in literature. The @entity3 after surgery was better with small @entity4 compared to large @entity4 . The intraoperative decision of near-total excision of the @entity1 followed by adjuvant radiotherapy, in some cases, can prove to be a good option in the interest of better preservation of the @entity3 . The adhesion of the facial nerve and its complex relationship with the @entity1 remain mysterious; RMI can bring significant refinements, helping to get the best preservation offacial function rate, in the coming years.

title: [Facial nerve outcome after XXXX surgery: About 89 @entity0 ].

answer: @entity4


abstract: BACKGROUND AND PURPOSE: In @entity0 with occlusion of the middle cerebral artery (MCA) treated by @entity3 ( @entity3 ), the distance to @entity1 (DT) has been proposed as a predictor of outcome. The purpose of the present study was to investigate how DT relates to dynamic susceptibility contrast perfusion metrics. METHODS: Retrospective analysis was undertaken of @entity0 who were diagnosed with @entity2 by magnetic resonance imaging and treated with @entity3 . Volumes of time-to-maximum (Tmax) perfusion deficits and diffusion-weighted imaging (DWI) lesions, diffusion-perfusion mismatch volumes, and the presence of target mismatch were determined. Correlations between the above stoke measures and DT were then calculated. RESULTS: Fifty-five @entity0 were included. DT showed significant inverse correlations with Tmax greater than 4, 6, 8, and 10   seconds, respectively, and mismatch volumes. Using the DT group median (14   mm) as a separator, significant intergroup differences were observed for Tmax greater than 4, 6, and 8   seconds, respectively, and for mismatch volumes. Grouping DT into quartiles showed significant intergroup differences regarding mismatch volumes and Tmax values greater than 4    and 6   seconds. Binary logistic regression identified DT (odds ratio [OR]   =   .89; 95% confidence interval [CI], .81-.99) and DWI lesion volumes (OR   =   .92; 95% CI, .86-.97) as independent predictors of target mismatch. A low DT predicted target mismatch with an area under the curve of .69. CONCLUSIONS: DT correlates inversely with Tmax perfusion deficits and mismatch volumes and acts as an independent predictor of target mismatch.

title: Distance to @entity1 in Acute XXXX Predicts Target Mismatch and Ischemic Penumbra.

answer: @entity2


abstract: BACKGROUND: The Aggrastat to Zocor (A to Z) and @entity6 or @entity5 Evaluation and Infection Therapy (PROVE IT) trials compared intensive and moderate statin therapy after @entity3 , with seemingly disparate results. We analyzed the design, implementation, and results of the two trials in an attempt to clarify the effects of early intensive statin therapy. METHODS AND RESULTS: Study design, end points, and definitions were compared. In each trial, comparisons were made between intensive and moderate arms for both trials' primary end points and @entity1 / @entity2 . Analyses were performed over various time points: at the end of the trials, < or =4 months, and >4 months. Subjects in A to Z had higher-risk demographics. More PROVE IT subjects were enrolled in the United States and underwent prerandomization revascularization. The low-density lipoprotein (LDL) difference was greater in A to Z than in PROVE IT early (< or =4 months) but less late. Significant @entity4 reduction was earlier in PROVE IT. With common end points, event rates were higher in A to Z, and early favorable separation of event curves was seen in PROVE IT but not in A to Z. Clinical end point rates and reductions were similar in both trials after 4 months. CONCLUSIONS: An early benefit was seen in PROVE IT but not in A to Z. Late-phase results were similar. Factors that may explain this disparity include the intensity of therapy in the early phase, timing, and magnitude of LDL and @entity4 lowering, differences in early revascularization, and the play of chance. Taken together, the results of these trials support a strategy of early intensive statin therapy coupled with revascularization when appropriate in @entity0 after @entity3 .

title: A tale of two trials: a comparison of the post- XXXX lipid-lowering trials A to Z and PROVE IT-TIMI 22.

answer: @entity3


abstract: To evaluate @entity2 screening with @entity4 testing (FOBT) in terms of prevention of advanced @entity1 , we conducted a case-control study in the areas where an annual screening programme with immunochemical FOBT has been offered to all inhabitants aged 40 years or over. Cases were 357 consecutive @entity0 in the study areas clinically diagnosed as having advanced @entity2 or a @entity1 invading the muscularis propriae or deeper, that is, T(2)-T(4) in TNM classification. Three controls were selected for each case matched by gender, age, residential area and exposure status to screening within 1 year before case diagnosis. The odds ratios (ORs) of developing @entity1 were calculated using conditional logistic regression analyses. The OR for those screened within 3 years before the diagnosis vs those not screened was 0.54 (95% confidence interval (CI) 0.29-0.99). The ORs were lower for rectum than for colon (0.32-0.73 and 0.84-1.18 for rectum and colon, respectively). For those screened within the past 3 years, OR of developing @entity1 in the rectum was 0.32 ( 95%CI: 0.12-0.84). A screening programme with immunochemical FOBT can be effective for prevention of advanced @entity2 . Risk reduction appears to be larger for rectal than for @entity3 . British Journal of @entity1 (2003) 89, 23-28. doi:10.1038/sj.bjc.6601002 www.bjcancer.com

title: Prevention of advanced XXXX by screening using the immunochemical @entity4 test: a case-control study.

answer: @entity2


abstract: BACKGROUND: Several studies have shown that @entity5 (NO)-releasing agents can kill @entity1 cells. Unfortunately, currently available NO delivery molecules do not target @entity1 cells preferentially. To exploit the overexpression of @entity4 transport proteins and the high level of @entity4 transport characteristics of @entity1 cells, @entity4 was conjugated to @entity9 ( @entity10 ) and evaluated for @entity3 in @entity0 @entity2 cells. METHODS: The @entity3 of @entity10 and SNAP was assessed by clonogenic cell survival assays performed in @entity11 ( @entity6 sensitive) and A2780cP ( @entity6 -resistant) @entity2 cells in vitro. Immunoblotting and immunohistochemistry were used to assess the expression of @entity7 @entity8 transport protein in the cell lines as well as in paraffin blocks from 28 surgical specimens of @entity2 . Apoptosis was assessed by an end-labeling assay. RESULTS: The @entity2 cell lines consistently were more sensitive to @entity10 than SNAP alone. The median effective doses (MEDs) for @entity10 and SNAP in the A2780s cell line were 0.0042 microM and 20.4 microM, respectively. Therefore, @entity10 was nearly 5000-fold more potent than the NO-donating moiety (SNAP) alone. In the A2780cP cells, the MED for @entity10 (0.38 microM) was 250-fold lower than that for SNAP alone (100 microM). Immunoblotting and immunohistochemistry studies showed overexpression of @entity7 in the cell lines and in 23 of 28 @entity2 specimens. CONCLUSIONS: The novel glyco-NO conjugate @entity10 exhibits a much greater @entity3 than the parent NO donor without the hexose moiety. These agents have the potential to target @entity1 cells preferentially, that overexpress @entity7 . This transporter is expressed highly in @entity2 .

title: Antitumor activity of a novel glyco- XXXX conjugate in @entity2 .

answer: @entity5


abstract: INTRODUCTION AND OBJECTIVE: @entity4 ( @entity5 ) is an antifibrinolytic drug used to reduce @entity3 in mortality risk situations such as @entity1 . Our objective was to conduct a systematic literature review to evaluate the effectiveness and safety of @entity5 in reducing @entity3 in hip arthroplasty. MATERIAL AND METHODS: A systematic literature review and meta-analysis of primary studies similar to controlled trials was performed. Literature was searched in MEDLINE, Embase, Cochrane, LILACS, SciELO and Google Scholar. The review was proposed and undertaken by 2 reviewers and the inclusion criteria were: a) @entity0 undergoing arthroplasty for primary unilateral hip replacement; b) comparison of a treatment group with @entity5 to a control group that received a placebo or no treatment at all, and c) outcome measures, @entity2 , number of @entity0 receiving allogeneic transfusion and/or incidence of @entity6 complications. The search was restricted to studies published from 1966 to June 2013. RESULTS: A total of 16 studies with 246 @entity0 were retrieved for this review. The @entity2 outcome evidenced a weighted mean difference in favor of @entity5 vs. controls undergoing hip arthroplasty (-0.45 [P<0.001, 95% CI -0.65 to -0.24]). Weighted relative risk was estimated for the allogeneic transfusion requirement outcome, showing a trend in favor the @entity5 arm, with fewer @entity0 requiring allogeneic transfusion in hip surgery (0.8 [P<0.02, 95% CI 0.57 to 1.11]); however, this trend was not statistically significant. LIMITATIONS: There is a noticeable difference in methods for quantifying @entity2 across the studies reviewed. The need for transfusion outcomes are probably not significant taking into account the number of events in the @entity5 group. CONCLUSIONS: @entity5 can be routinely used to reduce intra- and post-operative @entity2 in primary hip arthroplasty.

title: Efficiency of @entity4 in perioperative XXXX in hip arthroplasty: a systematic literature review and meta-analysis.

answer: @entity2


abstract: PURPOSE: In this proof-of-concept pilot study, our purpose was to determine correlations between gut microbiota composition and alterations in @entity4 and psychosocial outcomes among post-primary treatment @entity0 survivors (BCS). METHODS: Composition of the gut microbiota in BCS (n  =  12) was assessed at baseline (M0) and at the end of 3  months (M3) using Illumina MiSeq DNA Sequencing of the 16S rRNA gene. Gut microbiota composition was analyzed using the QIIME bioinformatics software and represented through diversity metrics and taxa analyses. @entity4 , @entity5 , @entity2 , @entity3 were assessed at M0 and M3 via the submaximal treadmill test, Fatigue Symptom Inventory, Hospital Anxiety and @entity3 Scale, and Pittsburgh Sleep Quality Index, respectively. RESULTS: Increased @entity5 interference in BCS was associated with increased mean within-sample Shannon diversity (organism richness and evenness) (p  =  0.009). Weighted UniFrac analysis (shifts in taxa relative abundance) revealed significant differences in between-sample (beta) diversity for changes in @entity5 interference (p  =  0.01) and @entity2 (p  =  0.022), with a trend observed for @entity5 @entity1 (p  <  0.1). Unweighted UniFrac analysis (shifts in taxa types) found significant beta diversity differences for @entity4 (p  =  0.026). Prior to false discovery correction (FDR), changes in fitness, @entity5 , @entity2 were associated with the frequency of certain gut bacteria genera (e.g., Faecalibacterium, Prevotella, Bacteroides) (p  <  0.05). CONCLUSIONS: Correlations may exist between alterations in gut microbiota composition and longitudinal changes in @entity4 , @entity5 , and @entity2 in BCS. Further research examining the role of the microbiota-gut-brain axis in exercise-induced effects on psychosocial outcomes in BCS is warranted.

title: Gut microbiota composition associated with alterations in XXXX and psychosocial outcomes among @entity0 survivors.

answer: @entity4


abstract: OBJECTIVE: The purpose of this study was to describe the epidemiological, clinical and evolution features of @entity7 ( @entity7 ). @entity0 AND METHODS: A retrospective study of 43 cases of @entity7 during the last 14 years (1984-1998) was performed. RESULTS: The mean age of the @entity0 was 3.2 years, the incidence during the summer season was the highest and 39 cases (90%) previously had @entity5 . All @entity0 had @entity6 , 32 of them (74%) required peritoneal dialysis. @entity9 was found in 22 case (51%) and the mean duration was 10.3 days. The most frequent complications were: @entity1 in 21 cases (48%), @entity3 in 9 cases (20%), @entity4 in 8 @entity0 (16%) and 3 deaths (6%). The mean hospital stay was 14.5 days. After one year of ambulatory control, 76% of the @entity0 were completely recovered and only two cases (6%) had @entity2 . @entity4 associated significantly with a bad prognosis (p < 0.05). CONCLUSIONS: @entity7 has a very important morbimortality. @entity4 in the acute phase were associated with a bad prognosis. @entity9 for more than 7 days and @entity8 for more than 15 days were also predictors of a worse prognosis, but this was not significant.

title: [ XXXX . Analysis of 43 cases].

answer: @entity7


abstract: BACKGROUND: Structural left ventricular remodeling after @entity3 is a complex process with several pathophysiologic descriptors that can be modified by pharmacotherapy. However, the possibility that different classes of antiremodeling agents might exert different effects on different remodeling parameters after reperfused and nonreperfused @entity3 has not been systematically studied. METHODS AND RESULTS: We measured detailed left ventricular remodeling parameters in vivo (echocardiograms) repeatedly over 6 weeks and ex vivo (planimetry) at 6 weeks after @entity3 in 36 @entity1 randomized (factorial design) after reperfused or nonreperfused @entity3 to 6 weeks of twice daily oral therapy with the @entity2 channel blocker @entity5 (5 mg), the angiotensin-converting enzyme inhibitor @entity6 (5 mg) or placebo, and 18 matching sham or control animals. Compared to placebo and control groups over 6 weeks, both agents reduced left ventricular loading and limited overall remodeling in both reperfused and nonreperfused groups, but there were pertinent differences. @entity6 limited the increase in left @entity0 in the reperfused group. Both @entity6 and @entity5 limited @entity4 zone thinning in the nonreperfused groups but increased @entity4 zone thinning in the reperfused groups, despite preserved @entity4 zone collagen with @entity5 . @entity6 decreased left ventricular diastolic volume and mass more than @entity5 in the reperfused group and increased left ventricular ejection fraction in the nonreperfused group. Both agents limited regional and global shape deformation in reperfused and non-reperfused groups. Diastolic wall stress in the @entity4 zone decreased with @entity5 , and increased with @entity6 and reperfusion. CONCLUSIONS: Different antiremodeling therapies may exert different effects on different remodeling parameters during healing after reperfused @entity3 . Significant interactions occur during reperfusion. More than one variable may be needed for the comprehensive assessment of the antiremodeling efficacy of different therapies.

title: Beneficial effects of therapy on the progression of structural remodeling during healing after reperfused and nonreperfused XXXX : different effects on different parameters.

answer: @entity3


abstract: We present a case of bilateral @entity8 , @entity5 . Cardiac, respiratory and central nervous system examinations were normal. An examination of the chest revealed @entity6 of the bilateral absence of the bilateral nipple-areola complex. Skin, soft tissue and bilateral pectoral muscles of the chest wall were normal. The @entity0 did not have scalp nodules or abnormal ears. Four hours after birth, an X-ray examination showed the distended intestinal loops, suggesting @entity4 . Exploration was performed and @entity7 was surgically identified. A primary @entity2 was performed. At 3 years of age, the @entity0 had mild mental and @entity3 . Chromosome analysis was normal (46,XX). Magnetic resonance imaging showed no abnormal finding in the spinal cord; however, mild @entity1 of the left cerebrum was pointed out. An abdominal echo examination showed no abnormal findings in the kidney. These associations may represent a previously undescribed syndrome spectrum.

title: A case of XXXX associated with bilateral athelia and @entity8 : new syndrome spectrum.

answer: @entity7


abstract: OBJECTIVE: Our aim was to evaluate the frequency and treatment of @entity2 symptoms in @entity0 at palliative care units (PCUs). METHOD: @entity0 admitted to one of five participating PCUs in Austria were included. The short version of the @entity0 Health Questionnaire (PHQ-D) was used to evaluate their mental health status. @entity3 intensity was rated on a numeric rating scale (NRS) from 0 to 10 by @entity0 and physicians. @entity0 with a previously diagnosed @entity2 were compared to those without or with newly diagnosed @entity2 symptoms, based on PHQ-D results. @entity3 and psychopharmacological medication were assessed. Opioid doses were converted into oral @entity5 equivalents (OMEs). RESULTS: Some 68 @entity0 were included. Previously undetected @entity2 symptoms were identified in 38% (26 of 68), preexisting @entity2 comorbidities were evident in 25% (17), and no @entity2 symptoms were observed in 37% (25). @entity0 with a preexisting @entity2 comorbidity received antidepressants and @entity4 significantly more often than @entity0 without or with previously undetected @entity2 symptoms (p < 0.001). @entity0 and physician median NRS ratings of @entity3 intensity correlated significantly (p = 0.001). Median NRS rating showed no significant difference between @entity0 with preexisting, previously undetected, or without @entity2 symptoms. OMEs did not differ significantly between preexisting, without, or previously undetected @entity2 symptoms. @entity0 with undetected and preexisting @entity2 comorbidities had a greater impairment in their activities of daily living than @entity0 without @entity2 symptoms (p = 0.003). SIGNIFICANCE OF RESULTS: Undetected @entity2 comorbidities are common in @entity0 receiving palliative care. Screening for @entity2 symptoms should be integrated into standard palliative care to optimize treatment and reduce the @entity1 .

title: Psyche at the end of life: Psychiatric symptoms are prevalent in XXXX admitted to a palliative care unit.

answer: @entity0


abstract: STUDY OBJECTIVE: To compare the effect of high-frequency oral airway oscillation, high-frequency chest wall oscillation, and conventional chest physical therapy ( @entity3 ) on weight of expectorated sputum, pulmonary function, and @entity1 saturation in outpatients with stable @entity4 ( @entity4 ). DESIGN: Prospective randomized trial. SETTING: Pediatric pulmonary division of a tertiary care center. @entity0 : Fourteen outpatients with stable @entity4 recruited from the @entity4 center. INTERVENTIONS: Two modes of oral airway oscillation (1: frequency 8 Hz; inspiratory to expiratory [I:E] ratio 9:1; 2: frequency 14 Hz; I:E ratio 8:1), two modes of chest wall oscillation (1: frequency 3 Hz; I:E ratio 4:1; 2: frequency 16 Hz; I:E ratio 1:1, alternating with frequency 1.5 Hz, I:E ratio 6:1), and @entity3 (clapping, vibration, postural drainage, and encouraged coughing) were applied during the first 20 min of 4 consecutive hours. MEASUREMENTS AND RESULTS: Sputum was collected on an hourly basis for a total of 6 consecutive hours. During the first and the last hour, @entity0 collected sputum without having any treatment and underwent pulmonary function tests (PFTs). @entity1 saturation was measured at 30-min intervals during hours 1 to 6. For the first 20 min of the second to the fifth hour, @entity0 received one of the treatments. To assess the effect of the intervention, the weight of expectorated sputum during hours 2 to 6 was averaged and expressed as percentage of the weight expectorated during the first hour (baseline). For the five treatment modalities, mean sputum dry and wet weights ranged between 122% and 185% of baseline. There was no statistically significant difference among the treatment modalities. As measured by sputum wet weight, all oscillatory devices tended to be less effective than @entity3 (p=0.15). As measured by dry weight, oral airway oscillation at 8 Hz with an I:E ratio of 9:1 and @entity3 tended to be more effective than the other treatment modalities (p=0.57). None of the treatment modalities had an effect on PFTs and @entity1 saturation and all were well tolerated. CONCLUSION: In outpatients with stable @entity4 , high-frequency oscillation applied via the airway opening or via the chest wall and @entity3 have comparable augmenting effects on expectorated sputum weight without changing PFTs or @entity1 saturation. In contrast to @entity3 , high-frequency oral airway and @entity2 are self-administered, thereby containing health-care expenses.

title: Effect of high-frequency oral airway and chest wall oscillation and conventional chest physical therapy on expectoration in @entity0 with stable XXXX .

answer: @entity4


abstract: INTRODUCTION: The objective of this study was to evaluate the feasibility of shear wave elastography (SWE), as a non-invasive means of assessing @entity3 stage in paediatric and adolescent @entity0 . MATERIALS AND METHODS: Consecutive paediatric and adolescent subjects scheduled for liver biopsy (LB) evaluation of known or suspected @entity2 were included after informed guardian consent and subject assent in this IRB-approved single institution study. Elastograms were acquired prior to liver biopsy, from the liver under a breath-hold after normal inspiration when possible. Biopsy specimens underwent blinded pathologist review using the METAVIR scoring system. RESULTS: Twenty-four @entity0 (M   :   F   =   13:11) with a mean age of 17 years (range: 1-21 years) underwent liver biopsy. The distribution of @entity1 on pathological examination was: F0   =   10, F1   =   9, F2   =   1, F3   =   3, and F4   =   1. Subjects with stages F0 and F1 @entity1 had a mean SWE value of 6.93   kPa (95% CI: 6.33-7.44   kPa) and 8.33   kPa (95% CI: 6.83-10.80   kPa) respectively. The SWE value for the one subject with stage F2 @entity1 was 6.36   kPa, whereas for @entity4 were 8.86 (95% CI: 5.70-11.40) and 17.85   kPa respectively. The correlation between SWE values and @entity1 grade was strong (r   =   0.58, P   =   0.003), and the area under the ROC curve differentiatiang >= F2 @entity1 was 0.62 (95% CI: 0.26-0.98). CONCLUSION: Estimation of liver stiffness using real-time SWE is feasible using the SC6-1 ultrasound probe in paediatric and adolescent @entity0 and strongly correlates with the stage of @entity1 .

title: Feasibility study for assessing @entity3 in paediatric and adolescent XXXX using real-time shear wave elastography.

answer: @entity0


abstract: To determine the optimal strategy for @entity0 screening, the cost-effectiveness of screening was analyzed using a medical decision model. One hundred thousand asymptomatic males between the ages of 40 and 69 were modeled with and without screening. The subjects were divided into three 10-year age groups. We used a 5-year survival rate as an effectiveness point and assumed after 5 year survival free from @entity0 . We considered three potential programs: 1) screening with digital rectal examination (DRE), 2) screening with @entity2 ) screening with a combination of DRE and @entity2 . The study was analyzed from the payer's perspective, and only direct medical costs were included. For each of the three age groups, @entity2 screening was more cost-effective than either DRE screening or a combination of DRE and @entity2 screening. The cost-effectiveness ratio for the combination of DRE and @entity2 screening was 1.1-2.3 times more expensive dian that of @entity2 screening. If the compliance rate for work-up exams is 80%, the cost-effectiveness of @entity0 screening is approximate to that of @entity1 screening. In conclusion, @entity2 screening is the most cost-effective strategy for @entity0 screening when compared with both DRE and the combination of DRE and @entity2 screening. But @entity0 screening should be carefully conducted, taking the cost-effectiveness of the different strategies and target groups into consideration.

title: Cost-effectiveness analysis of XXXX screening.

answer: @entity0


abstract: The origins of the a- and b-wave of the @entity4 were studied using simultaneous recordings made across the receptor layer and the full thickness of a piece of isolated albino @entity0 retina. An inwardly directed current flowing across the rod outer segments was eliminated from the recording when postsynaptic activity was blocked with @entity2 or when current source density measurements were made along the length of the outer segments. Rod photovoltages were inferred by removing extraneous field potentials from the recordings made across the photoreceptor layer. The spatial properties of the photovoltage indicates the responses came from an area about 100 microm in diameter. The @entity3 analog. APB, which blocks depolarizing bipolar cells, eliminated the b-wave but left the a-wave unaffected. The @entity4 component due to depolarizing bipolar cells was inferred by subtracting recordings obtained before and after APB. After treatment with APB a slow component remained. This component was completely blocked by barium (200 microM), which blocks @entity1 channels on M  ller cells. Barium had virtually no effect on low-intensity photovoltages but did affect the amplitude and shape of the saturated responses. Barium increased the amplitude of the component of the @entity4 which underlies the b-wave. It was concluded that the depolarizing bipolar cells directly generate the b-wave of the @entity4 .

title: A dissection of the electroretinogram from the isolated XXXX retina with microelectrodes and drugs.

answer: @entity0


abstract: Insects, like all invertebrates, express robust innate, but not adaptive, immune reactions to infection and invasion. Insect immunity is usually resolved into three major components. The integument serves as a physical barrier to infections. Within the hemocoel, the circulating hemocytes are the temporal first line of defense, responsible for clearing the majority of infecting bacterial cells from circulation. Specific cellular defenses include phagocytosis, microaggregation of hemocytes with adhering bacteria, nodulation and encapsulation. Infections also stimulate the humoral component of immunity, which involves the induced expression of genes encoding antimicrobial peptides and activation of prophenoloxidase. These peptides appear in the hemolymph of challenged insects 6-12 hours after the challenge. @entity2 and other @entity1 are crucial mediators of innate immune responses. @entity3 biosynthesis is stimulated by infection in insects. Inhibition of @entity3 biosynthesis lethally renders experimental insects unable to clear bacterial infection from hemolymph. Eicosanoids mediate specific cell actions, including phagocytosis, microaggregation, nodulation, hemocyte migration, hemocyte spreading and the release of prophenoloxidase from oenocytoids. Some invaders have evolved mechanisms to suppress insect immunity; a few of them suppress immunity by targeting the first step in the @entity3 biosynthesis pathways, the enzyme @entity4   . We proposed research designed to cripple insect immunity as a technology to improve biological control of insects. We used dsRNA to silence insect genes encoding @entity4   , and thereby inhibited the nodulation reaction to infection. The purpose of this article is to place our view of applying dsRNA technologies into the context of @entity3 actions in insect immunity. The long-term significance of research in this area lies in developing new pest management technologies to contribute to food security in a world with a rapidly growing @entity0 population.

title: XXXX : Exploiting Insect Immunity to Improve Biological Control Programs.

answer: @entity1


abstract: We present two techniques utilizing independent component analysis (ICA) to remove large muscle artifacts from @entity1 ( @entity1 )-evoked EEG signals. The first one is a novel semi-automatic technique, called @entity2 ( @entity2 ). @entity2 is a modification of the deflation mode of the FastICA algorithm; with an enhanced independent component search, @entity2 is an effective tool for removing the large, spiky muscle artifacts. The second technique, called manual method (MaM) makes use of the symmetric mode of FastICA and the artifactual components are visually selected by the user. In order to evaluate the success of the artifact removal methods, four different quality parameters, based on curve comparison and frequency analysis, were studied. The dorsal premotor cortex (dPMC) and Broca's area (BA) were stimulated with @entity1 . Both methods removed the very large muscle artifacts recorded after stimulation of these brain areas. However, @entity2 was more stable, less subjective, and thus also faster to use than MaM. Until now, examining lateral areas of the cortex with @entity1 -EEG has been restricted because of strong muscle artifacts. The methods described here can remove those muscle artifacts, allowing one to study lateral areas of the @entity0 brain, e.g., BA, with @entity1 -EEG.

title: Removal of large muscle artifacts from XXXX -evoked EEG by independent component analysis.

answer: @entity1


abstract: PURPOSE: To compare the expression rate of sex @entity2 hormone receptors of @entity4 (ER), @entity6 (PR) and @entity5 (AR) in normal urothelium and @entity3 ( @entity3 ) and to evaluate the possible associations of these receptors expression with @entity1 progression and @entity0 's survival. MATERIALS AND METHODS: We evaluated the clinical data and @entity1 specimens of 120 @entity0 with pathologically confirmed primary @entity3 with 132 normal healthy controls. Both @entity0 and controls selected from list of subjects who have been referred to Sina Urology clinic, and had a minimum of one year follow-up duration. Data collected from medical cords. For evaluation of expression, immunohistochemistry was performed on paraffin-embedded tissue sections using a monoclonal antibody for @entity5 , @entity4 and @entity6 receptors. Presence of at least 10% positive cells defined as positive expression. RESULTS: None of the control subjects showed AR expression, while 22% of the @entity0 were AR-positive. ER/PR expressions were observed in 4.2%/ and 2.5% of the cases and in 2.3% and 1.5% of the controls, respectively. A statistically significant correlation was found between AR expression and @entity1 stage and grade (P < .001). AR-positive @entity0 showed a significantly poorer prognosis than AR-negative cases (log-rank test, P = .02, hazard ratio = 2.12; 95% confidence interval: 1.36-4.65). CONCLUSION: AR expression was significantly associated with higher grade and poorly differentiated @entity1 with unfavorable outcome. AR expression test might be useful as a diagnostic tool for determining the malignancy and outcome of @entity3 @entity0 ._

title: Role of XXXX hormone receptors in formation and progression of @entity3 : a case-control study.

answer: @entity2


abstract: BACKGROUND _ AIMS: @entity3 is a strong risk factor for @entity4 , but it is not clear whether the @entity2 that develops in @entity0 with @entity3 promotes this @entity1 . We determined the development of @entity4 among @entity0 who underwent esophagogastroduodenoscopy and were found to have erosive (with @entity5 ) or nonerosive (without @entity5 ) reflux. METHODS: We performed a nationwide cohort study using data from 33,849 @entity0 with @entity3 (52% @entity0 ; median age, 59.3 y) from population-based Danish medical registries, from 1996 through 2008. The observed incidences of @entity4 were compared with the expected incidence for the general population, standardized by age, sex, and calendar time. Absolute risks were estimated using Kaplan-Meier methods. RESULTS: In the study cohort, 26,194 of the @entity0 (77%) had @entity3 and 37 subsequently developed @entity4 after a mean follow-up time of 7.4 years. Their absolute risk after 10 years was 0.24% (95% confidence interval [CI], 0.15%-0.32%). The incidence of @entity1 among @entity0 with @entity3 was significantly greater than that expected for the general population (standardized incidence ratio, 2.2; 95% CI, 1.6-3.0). In contrast, of the 7655 @entity0 with nonerosive @entity3 , only 1 was diagnosed with @entity4 after 4.5 years of follow-up evaluation (standardized incidence ratio, 0.3; 95% CI, 0.01-1.5). CONCLUSIONS: @entity3 , but not nonerosive disease, increased the risk of @entity4 , based on analysis of population-based Danish medical registries. @entity2 therefore might be an important factor in the progression from reflux to @entity4 .

title: XXXX increases risk for @entity4 , compared with nonerosive reflux.

answer: @entity3


abstract: We recently developed a simple and fast assay technique, providing the possibility of monitoring of @entity3 (M) during sedation. We compared HPLC vs FPIA for the measurement of the sum M plus alpha @entity4 (OM), its main and pharmacologically active metabolite, in the serum of sedated ICU @entity0 ; this activity referred to as M-like. We identified certain @entity0 in whom M-like activity appeared abnormally high in comparison with HPLC assays. Their common denominators were: long-term sedation with M, and seriously @entity1 . Further, the conjugates of OM (OMG) accumulated in @entity0 with @entity2 could contribute to the sedation. We compared the metabolic and analytic behavior of M, OM, and OMG in 2 groups of sedated @entity0 either presenting with normal renal functions (group 1) or with a picture of @entity2 (group 2). Blood samples were assayed by HPLC and by FPIA and analysis was performed before and after hydrolysis of OMG. Before hydrolysis there was a dramatic accumulation of OMG in the @entity0 of group 2, HPLC vs FPIA results were not different within group 1, while in group 2 the FPIA response exceeded that of HPLC. After hydrolysis, measurement by HPLC was greatly increased in group 2, in each group (vs HPLC) and from one group to another, the FPIA signal (the M-like activity) showed a significant increase. It would be important to take OMG into account as a coprotagonist in sedation whenever circumstances predispose to its accumulation.

title: Influence of XXXX on FPIA rapid serum assay of @entity3 and its main metabolite.

answer: @entity2


abstract: OBJECTIVE: To determine whether a motion control running shoe reduces @entity1 in the transverse plane during treadmill running. DESIGN: An experimental study measuring @entity1 in volunteer @entity0 using a repeated measures design. SETTING: @entity0 Movement Laboratory, School of Health Professions, University of Brighton. @entity0 : Twenty-four healthy @entity0 were tested. The group comprised males and females with size 6, 7, 9 and 11 feet. The age range for @entity0 was 19 to 31 years. MAIN OUTCOME MEASURES: The total range of proximal @entity1 was measured using the Codamotion 3-D Movement Analysis System. RESULTS: A one-tailed paired t-test indicated a statistically significant decrease in the total range of proximal @entity1 when a motion control shoe was worn (mean difference 1.38  , 95% confidence interval 0.03 to 2.73, P=0.04). CONCLUSIONS: There is a difference in @entity1 in the transverse plane between a motion control running shoe and a neutral running shoe. The results from this study have implications for the use of supportive running shoes as a form of injury prevention.

title: Effect of motion control running shoes compared with neutral shoes on XXXX during running.

answer: @entity1


abstract: PURPOSE: To test the hypothesis that taking translamina pressure difference into consideration changes associations between ocular perfusion pressure and glaucomatous @entity2 . METHODS: The population-based Central India Eye and Medical Study included 4711 subjects. Ocular perfusion pressure was calculated as follows:     [diastolic blood pressure +     * (systolic blood pressure - diastolic blood pressure)] - IOP. Cerebrospinal fluid pressure (mm Hg) was estimated as follows: 0.44 body mass index (kg/m(2)) + 0.16 diastolic blood pressure (mm Hg) - 0.18 * age (years) - 1.91. Translamina pressure difference was IOP minus cerebrospinal fluid pressure. RESULTS: In multivariate analysis, higher @entity1 prevalence was associaed with higher IOP (P<.001; odds ratio [OR], 1.19; 95% CI, 1.15, 1.24) or with higher translamina pressure difference (P<.001; OR, 1.15; 95% CI, 1.10, 1.19), but not with ocular perfusion pressure (P<.37). A smaller neuroretinal rim area was correlated with higher IOP (P<.001; standardized coefficient beta -0.09) or larger translamina pressure difference (P<.001; b -0.10), but not with ocular perfusion pressure (P=.26). Greater prevalence of @entity3 was associated with higher IOP (P<.001; OR, 1.22; 95% CI, 1.15, 1.28) or higher translamina pressure difference (P<.001; OR, 1.19; 95% CI, 1.13, 1.25) or lower ocular perfusion pressure (P<.04; OR, 0.95; 95% CI, 0.90, 0.996). Correlation coefficients were highest for the association with IOP and lowest for ocular perfusion pressure. A smaller rim area was correlated with higher IOP (P<.001; beta -0.08) and higher translamina pressure difference (P<.001; beta -0.08); rim area and ocular perfusion pressure were not significantly associated (P=.25). CONCLUSIONS: The present study provides information on the relationship of translamina pressure difference to the development of @entity2 in what is presently called @entity0 . It does not provide support of the idea that ocular perfusion pressure plays a major role in the pathogenesis of @entity2 .

title: Ocular Perfusion Pressure vs Estimated Trans-Lamina Cribrosa Pressure Difference in XXXX : The Central India Eye and Medical Study (An American Ophthalmological Society Thesis).

answer: @entity0


abstract: Measurement of glomerular filtration rate (GFR) following the injection of one of several suitable marker substances remains the best method to determine the severity of @entity0 as well as its rate of progression. However, the expense of these procedures continues to restrict their use. A second alternative is the determination of @entity1 clearance (CCr) after oral administration of @entity2 . This drug blocks tubular secretion of @entity1 almost completely, and CCr measured under these conditions is reported to be nearly identical to GFR in mild or severe @entity0 . The optimal dose and timing of @entity2 for this purpose is still uncertain, but a single 1,200-mg dose 2 hours before beginning urine collection is probably suitable. A third alternative is simply the measurement of serum or plasma @entity1 (PCr) concentration. However, it is well established that substantial reductions in renal function may occur before PCr becomes abnormal. GFR in adults with @entity0 can be approximately estimated from PCr, provided it is greater than 2 mg/dL, with the aid of additional demographic and biochemical variables. Gender, height, weight, age, and race should be taken into account. Further study is needed to derive the best formula for predicting GFR from PCr and other variables. Finally, CCr (without @entity2 ) is still in use. This is unfortunate because it has been established that rather than improving on the estimation of GFR from PCr, CCr (determined from urinary @entity1 measurements as well as PCr) is a less reliable guide to GFR than PCr alone. The CCr/GFR ratio is almost always greater than unity and increases with decreasing GFR to a maximum of approximately 1.7 at a GFR of approximately 20 mL/min. Furthermore, the variability of CCr is greater than that of PCr. Measurement of CCr (without @entity2 ) is an anachronism and should be abandoned.

title: Assessing renal function from XXXX measurements in adults with @entity0 .

answer: @entity1


abstract: OBJECTIVE: To validate the feasibility of using the parameters of spectral CT and CT perfusion and the dynamic features of real-time @entity1 ( @entity1 ) to evaluate the vascularization of VX2 @entity0 . METHODS: Spectral CT imaging, CT perfusion and @entity1 analysis were performed on @entity3 implanted with VX2 @entity0 , 7 and 14 days after implantation. The perfusion parameters of CT, normalized @entity5 concentration (NIC) and dynamic features of @entity1 were measured in the rim of the @entity0 ( @entity0 ) and the normal liver region. The expression of @entity2 ( @entity2 ) and @entity6 ( @entity6 ) was also determined. RESULTS: Increased perfusion parameters of CT were found in the @entity0 . In addition, the NIC was elevated in @entity0 during the arterial phase, and the peak intensity of the @entity1 of the @entity0 was reached significantly earlier than that on normal liver region. At 14 days, the perfusion parameters of CT (blood volume, permeability surface and hepatic arterial fraction) offered higher accuracy and stability in differentiating the @entity0 from the normal liver region. Furthermore, @entity1 was more accurate in diagnosing @entity0 <1.0   cm in diameter. In addition, @entity2 and @entity6 expression was higher in the @entity0 and were positively correlated with CT and @entity1 parameters, except mean transit time, rise time, washout time and peak time. CONCLUSION: Use of spectral CT with perfusion techniques, @entity5 -based material-decomposition analysis and dynamic @entity1 changes may reflect the angiogenesis and @entity0 . Advances in knowledge: It is feasible to assess vascularization in @entity4 using CT or @entity1 .

title: Evaluation of neovascularization with spectral computed tomography in a @entity3 VX2 liver model: a comparison with real-time XXXX and molecular biological findings.

answer: @entity1


abstract: The threat of radiation-induced late normal tissue injury limits the dose of radiation that can be delivered safely to @entity1 @entity0 presenting with solid @entity1 . Tissue dysfunction and failure, associated with @entity6 , @entity5 and/or @entity4 , as well as @entity7 , have been reported in late responding normal tissues, including the central nervous system, gut, kidney, liver, lung, and skin. The precise mechanisms involved in the pathogenesis of radiation-induced late normal tissue injury have not been fully elucidated. It has been proposed recently that the radiation-induced late effects are caused, in part, by chronic oxidative stress and @entity3 . Increased production of reactive @entity2 species, which leads to lipid peroxidation, oxidation of DNA and proteins, as well as activation of pro-inflammatory factors has been observed in vitro and in vivo. In this review, we will present direct and indirect evidence to support this hypothesis. To improve the long-term survival and quality of life for radiotherapy @entity0 , new approaches have been examined in preclinical models for their efficacy in preventing or mitigating the radiation-induced chronic normal tissue injury. We and others have tested drugs that can either @entity3 or reduce chronic oxidative stress in animal models of late radiation-induced normal tissue injury. The effectiveness of renin-angiotensin system blockers, peroxisome proliferator-activated receptor (PPAR) gamma agonists, and antioxidants/antioxidant enzymes in preventing or mitigating the severity of radiation-induced late effects indicates that radiation-induced @entity8 can be prevented and/or treated. This provides a rationale for the design and development of anti-inflammatory-based interventional approaches for the treatment of radiation-induced late normal tissue injury.

title: XXXX and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications.

answer: @entity3


abstract: OBJECTIVE: To test the hypothesis that early postnatal @entity9 will reduce the incidence of @entity4 or @entity11 ( @entity11 ) in ventilated @entity8 premature @entity0 . DESIGN: Multicenter randomized double-blinded controlled clinical trial. SETTING: A total of 42 neonatal intensive care units in the Vermont Oxford Network. @entity0 : @entity0 weighing 501 to 1000 g were eligible for enrollment at 12 hours of age if they needed assisted ventilation, had received surfactant replacement therapy, were physiologically stable, had no obvious life-threatening @entity3 , and had blood cultures obtained and antibiotic therapy initiated. INTERVENTION: @entity0 were randomly assigned to @entity9 or saline placebo. Intravenous @entity9 was administered for 12 days according to the following dosing schedule: 0.5 mg/kg/d for 3 days, 0.25 mg/kg/d for 3 days, 0.10 mg/kg/d for 3 days, 0.05 mg/kg/d for 3 days. @entity0 in either group could receive treatment with selective late postnatal @entity5 beginning on day 14 of life if they were on assisted ventilation with supplemental @entity1 greater than 30%. OUTCOME MEASUREMENTS: The primary outcome measure was @entity11 or @entity4 at 36 weeks postmenstrual age. RESULTS: The study was stopped before completion of sample size goals because of concern about serious side effects in the early @entity2 treatment group. A total of 542 @entity0 were enrolled (early treatment N = 273, control N = 269). The 2 groups had similar demographic characteristics. No differences were noted in the primary outcome of @entity11 or @entity4 at 36 weeks postmenstrual age (early treatment 50% vs control: 53%, relative risk: 0.93; 95% confidence interval [CI]: 0.79-1.09). Fewer @entity0 who received early @entity2 treatment had a patent ductus arteriosus (relative risk: 0.78; 95% CI: 0.63-0.96), and fewer @entity0 in the early @entity2 group received @entity12 therapy (relative risk: 0.74; 95% CI: 0.64-0.86) or late @entity2 treatment (relative risk: 0.69; 95% CI: 0.58-0.81). However, more @entity0 who received early @entity2 treatment had complications associated with therapy including an increase in @entity13 (relative risk: 1.29; 95% CI: 1.13-1.46) and an increase in the use of insulin therapy (relative risk: 1.62; 95% CI: 1.36-1.94). A trend toward increased @entity7 (relative risk: 1.55; 95% CI: 0.92-2.61), @entity6 (relative risk: 1.53; 95% CI: 0.89-2.61), and an increased systolic blood pressure (relative risk: 1.34; 95% CI: 0.97-1.85) was noted. In @entity0 receiving cranial ultrasound examinations, a marginal increase in @entity14 was noted in the early @entity2 treatment group (relative risk: 2.23; 95% CI: 0.99-5.04). @entity0 who received early @entity2 therapy had fewer days in supplemental @entity1 but experienced poor @entity10 . CONCLUSIONS: A 12-day course of early postnatal @entity2 therapy given to @entity8 @entity0 did not decrease the risk of @entity11 or @entity4 at 36 weeks postmenstrual age and was associated with an increased risk of complications and poor @entity10 .

title: Early postnatal @entity9 therapy for the prevention of XXXX .

answer: @entity11


abstract: OBJECTIVE: The incidence of @entity5 in @entity0 with @entity6 ( @entity6 ) is 25 to 50-fold higher than in the general population; we aimed to define the characteristics of @entity2 ( @entity2 ) and @entity5 ( @entity5 ) to identify the @entity0 at highest risk. METHODS: The study included 219 @entity0 with recent-onset @entity6 . At baseline, standardized medical history and laboratory tests were done. Followup visits occurred quarterly, and information about damage accrual, comorbidities, and cardiovascular risk factors was updated annually. Main outcome was development of TE after @entity6 diagnosis. RESULTS: Thirty-five @entity0 (16%) developed TE (27 @entity2 , 8 @entity5 ) during 5.21 years of followup; incidence rate 31/1000 @entity0 -years. Most events (57%) developed within the first year of diagnosis, and 69% were not associated with @entity10 ( @entity10 ), determined with 1 method. @entity2 developed earlier than @entity5 (2.0 vs 57.5 mos, p = 0.02). In the multivariate analysis, variables preceding @entity2 included @entity7 , @entity8 , dose of @entity4 , and @entity10 in combination with anti-RNP/Sm antibodies (p < 0.03). @entity0 with @entity5 were older (median age 44 vs 29 yrs, p = 0.04), smokers, and had @entity3 , @entity1 , @entity9 , at least 2 traditional risk factors, @entity8 , @entity11 , and a higher cumulative dose of @entity4 (p < 0.05). @entity10 in combination with anti-RNP/Sm antibodies was associated with @entity2 and improved the accuracy for predicting it. CONCLUSION: Our study suggests that in @entity6 , @entity2 and @entity5 have different risk factors. Understanding these differences is helpful for identifying @entity0 at highest risk. The use of @entity10 plus anti-RNP/Sm for predicting @entity2 deserves further study.

title: Venous and Arterial XXXX Events in @entity6 .

answer: @entity5


abstract: BACKGROUND AND STUDY AIMS: Whereas data on moderate nurse-administered @entity3 sedation (NAPS) efficacy and safety for standard endoscopy is abundant, few reports on the use of deep sedation by endoscopy nurses during advanced endoscopy, such as @entity4 ( @entity4 ) and Endoscopic Ultrasound (EUS) are available and potential benefits or hazards remain unclear. The aims of this study were to investigate the efficacy of intermittent deep sedation with @entity3 for a large cohort of advanced endoscopies and to provide data on the safety. @entity0 AND METHODS: All available data from @entity0 sedated with intermittent deep NAPS for @entity4 , EUS or double balloon enteroscopy (DBE, since the method was implemented in May 2007 through December 2012 were included for evaluation in a retrospective case-control design. RESULTS: Data from 1899 @entity0 undergoing 1899 procedures were included for evaluation. All but one procedure were completed with intermittent deep NAPS.The mean @entity3 dose was 397mg (SD: 232.4) and the infusion rate was 23.9mg/kg. The frequency of @entity1 was 4.3% and 20 @entity0 needed assisted ventilation (1.1%). Anesthesiologic support was requested eight times (0.4%). One @entity0 was intubated due to suspected aspiration. CONCLUSIONS: Intermittent deep NAPS for advanced endoscopies in selected @entity0 provided an almost 100% success rate. However, the rate of @entity1 , @entity2 and respiratory support was high compared with previously published data, but the method was still assessed as safe.

title: High efficacy with deep nurse-administered XXXX sedation for advanced gastroenterologic endoscopic procedures.

answer: @entity3


abstract: Given that @entity0 ( @entity0 ) occurs in approximately 5 out of 1,000 adults of European descent and the unclear pathogenesis, the aim of the research was to further predict the molecular mechanism of this disease. The Affymetrix chip data GSE25101 were available from Gene Expression Omnibus database. First of all, differentially expressed genes (DEGs) were identified by Limma package in R. Moreover, DAVID was used to perform gene set enrichment analysis of DEGs. In addition, miRanda, miRDB, miRWalk, RNA22 and TargetScan were applied to predict microRNA-target associations. Meanwhile, STRING 9.0 was utilized to collect protein-protein interactions (PPIs) with confidence score  >0.4. Then, the PPI networks for up- and down-regulated genes were constructed, and the clustering analysis was undergone using ClusterONE. Finally, protein-domain enrichment analysis of modules was conducted using DAVID. Total 145 DEGs were identified, including 103 up-regulated and 42 down-regulated genes. These DEGs were significantly enriched in phosphorylation (p  =  1.21E-05) and positive regulation of gene expression (p  =  1.25E-03). Furthermore, one module was screened out from the up-regulated network, which contained 39 nodes and 205 edges. Moreover, the nodes in the module were significantly enriched in ribosomal protein ( @entity2 , @entity2 and @entity4 , mitochondrial @entity1 ) and proteasome ( @entity5 , @entity3 )-related domains. Our findings that might explore the potential pathogenesis of @entity0 and @entity2 , @entity4 , @entity5 and @entity3 have the potential to be the biomarkers for the disease.

title: Predicting the potential XXXX -related genes utilizing bioinformatics approaches.

answer: @entity0


abstract: INTRODUCTION: The 90-day risk of @entity4 in @entity0 with @entity8 ( @entity8 ) is estimated at between 8% and 20%. There is little consensus as to which diagnostic strategy is most effective. This study evaluates the benefits of early transthoracic echocardiography (TTE) with carotid and transcranial Doppler ultrasound in @entity0 with @entity8 . METHODS: Prospective study of @entity0 with @entity8 in an emergency department setting. Demographic data, vascular risk factors, and @entity9 ) score were analysed. @entity8 aetiology was classified according to TOAST criteria. All @entity0 underwent early vascular studies (<72hours), including TTE, carotid ultrasound, and transcranial Doppler. Primary endpoints were recurrence of @entity1 or @entity8 , @entity6 ( @entity6 ), or @entity2 during the first year. RESULTS: We evaluated 92 @entity0 enrolled over 24 months. Mean age was 68.3  13 years and 61% were male. The mean @entity9 ) score was 3 points (>= 5 in 30%). The distribution of @entity8 subtypes was as follows: 12% large-artery @entity7 ; 30% cardioembolism; 10% small-vessel occlusion; 40% undetermined cause; and 8% rare causes. Findings from the early TTE led to a change in treatment strategy in 6 @entity0 (6.5%) who displayed normal physical examination and ECG findings. At one year of follow-up, 3 @entity0 had experienced @entity1 (3.2%) and 1 @entity0 experienced @entity6 (1%); no vascular @entity2 were identified. CONCLUSIONS: In our @entity8 @entity0 , early vascular study and detecting @entity0 with silent @entity3 may have contributed to the low rate of @entity5 recurrence.

title: Rapid diagnosis and treatment of @entity8 results in low rates of @entity1 , XXXX and @entity2 .

answer: @entity6


abstract: INTRODUCTION: Most visits to the primary care center are for @entity1 and particularly respiratory tract @entity1 . Antimicrobial administration for these clinical processes is common and these agents are often used to treat @entity4 . La Fundaci  n para el Estudio de la Infecci  n (Foundation for the Study of Infection) designed the @entity2 (D  a de la Infecci  n Respiratoria del Adulto, Adult Respiratory Infection Day) Project to investigate and assess the impact of this problem. METHODS: The study design consisted of one-day cross sections with the participation of 720 physicians belonging to Primary Health Care Centers from the 17 Autonomic Regions of Spain, establishing a one-day cross section every three months for one year. Epidemiologic, clinical and therapeutic factors were evaluated. RESULTS: The total number of visits attended was 72 929, and 14 426 @entity0 had infectious processes (43.9%). Among these, 9145 (63.4%) had a @entity3 . The mean age of the @entity0 was 44.6 years and 34.1% had an underlying condition. Common cold was the most frequent diagnosis. Antibiotics were prescribed in 53.2% of @entity0 . Results were compared to those of a previous study. DISCUSSION: @entity3 in particular is frequently attended in primary care. Antibiotics are widely used in our setting and self-medication is common.

title: [ @entity3 outside the hospital. XXXX study].

answer: @entity2