abstract: BACKGROUND: Hyperbaric @entity1 (HBO) has been proven to enhance bone and soft tissue healing in @entity2 tissue in vitro and in vivo studies. Although only a few reports have been proven using controlled studies, this treatment modality remains encouraging for @entity7 . In this retrospective study, we reported the clinical results of HBO therapy for @entity7 . METHODS: From January through August 2000, 14 @entity0 with @entity7 treated with HBO were available for follow-up examination. According to the Cierny-Mader classification, all @entity0 were classified as type III or IV @entity5 . Adequate debridement and parenteral antibiotic treatment in conjunction with HBO therapy at 2.5 atmospheres absolute for 120 minutes, and 5 days per week regimen was used in all @entity0 . The @entity0 were followed-up for an average of 15 months after completion of HBO therapy. RESULTS: The most common infecting microorganism was @entity4 . Mixed @entity3 were usually found in @entity0 with @entity6 . The average number of operations before HBO therapy was 5.4 including soft tissue reconstruction in 11 @entity0 . The average number of HBO treatments was 33.6 times. There were no HBO related complications. No recurrence of @entity3 was noted in 11 @entity0 , which resulted in a success rate of 79%. CONCLUSIONS: Hyperbaric @entity1 therapy is effective and safe for @entity7 provided that @entity0 had received appropriate medical and surgical management.

title: Hyperbaric @entity1 therapy in the treatment of XXXX : a preliminary report.

answer: @entity7


abstract: The air crescent sign is regarded as an important diagnostic finding in invasive @entity2 (IPA). This study examined the incidence, clinical importance, and natural history of air crescents in 25 @entity0 with @entity6 and IPA. Twelve (50%) of the @entity0 had cavities (ten with an air crescent) that appeared an average of 15 days after the initial infiltrate. The diagnostic utility of the air crescent sign was relatively minor; cavities developed after the diagnosis was established in 50% of cases and after therapy was started in 75% of cases. In each case, the @entity1 improved at the time of cavitation. In six @entity0 (50%), the cavities resolved over 2-8 months. Three @entity0 (25%), however, experienced massive hemoptysis. Air crescent formation, previously shown to be dependent on granulocyte recovery, was associated with improved survival (67%) compared with the group without cavitation (8%). In the latter group, the @entity1 in ten (77%) of 13 @entity0 progressed to diffuse disease. In @entity0 with @entity5 , the diagnostic value of the air crescent sign is limited by cavities that develop relatively late, as the infection improves after white blood cell recovery; cavities that do not occur in @entity0 who remain @entity4 ; and associated @entity3 , at times life-threatening, that obscures the air crescent. The diagnosis of IPA should not await observation of air crescents in these @entity0 .

title: Invasive XXXX and @entity6 . Limitations in the diagnostic utility of the air crescent sign.

answer: @entity2


abstract: BACKGROUND: Treatment guidelines for typical @entity1 recommend observation alone after resection of stage I-IIIA disease, but there are limited data related to the use of adjuvant chemotherapy in the setting of nodal metastases found at operation. METHODS: @entity0 in the National Cancer Data Base (NDCB) who underwent lobectomy for typical @entity2 and had metastatic nodal disease were stratified by the use of adjuvant chemotherapy. Baseline characteristics and outcomes were compared between groups. Next, @entity0 were propensity matched using a 3:1 nearest-neighbor algorithm, and adjusted outcomes were compared. Finally, long-term survival was evaluated using the Kaplan-Meier method with comparisons based on the log-rank test. RESULTS: Overall, 4,612 @entity0 were identified, among whom 629 (13.6%) had positive lymph nodes at the time of operation. Of them, adjuvant chemotherapy was used in 37 @entity0 (5.9%). There were no baseline differences between @entity0 who did and those who did not receive adjuvant chemotherapy. @entity0 treated with chemotherapy demonstrated a survival disadvantage at 5 years (69.7% versus 81.9%; p  = 0.042). After propensity matching, all baseline characteristics between groups were highly similar. There remained a trend toward inferior 5-year survival for @entity0 who received adjuvant chemotherapy, although the difference no longer met statistical significance (69.7% versus 80.9%; p  =  0.096). CONCLUSIONS: Adjuvant chemotherapy is not associated with improved survival among @entity0 who undergo lobectomy for @entity2 and nodal metastases. These data support current treatment guidelines.

title: Defining the Role of Adjuvant Chemotherapy After Lobectomy for Typical XXXX .

answer: @entity1


abstract: OBJECTIVE: To examine socioeconomic differences in case fatality and prognosis of @entity3 ( @entity3 ) events, and to estimate the contributions of incidence and case fatality to socioeconomic differences in @entity2 ( @entity2 ) mortality. DESIGN: A population-based @entity3 register study. METHODS: The FINMONICA @entity3 Register recorded all @entity3 events among @entity0 aged 35-64 years in three areas of Finland during 1983-1992. A record linkage of the @entity3 Register data with the files of Statistics Finland was performed to obtain information on socioeconomic indicators for each individual registered. First @entity3 events (n=8427) were included in the analyses. MAIN RESULTS: The adjusted risk ratio of prehospital coronary @entity1 was 2.11 (95% CI 1.82, 2.46) among @entity0 and 1.68 (1.14, 2.48) among @entity0 with low income compared with those with high income. Even among @entity0 hospitalised alive the risk of @entity1 during the next 12 months was markedly higher in the low income group than in the high income group. Case fatality explained 51% of the @entity2 mortality difference between the low and the high income groups among @entity0 and 38% among @entity0 . Incidence contributed 49% and 62%, respectively. CONCLUSIONS: Considerable socioeconomic differences were observed in the case fatality of first coronary events both before hospitalisation and among @entity0 hospitalised alive. Case fatality explained a half of the @entity2 mortality difference between the low and the high income groups among @entity0 and more than a third among @entity0 .

title: Relation of socioeconomic position to the case fatality, prognosis and treatment of XXXX events; the FINMONICA @entity3 Register Study.

answer: @entity3


abstract: More @entity0 are now being diagnosed with nonpalpable @entity2 after a needle biopsy is performed for an elevated prostate-specific antigen (PSA) level (stage T1c). The purpose of this study was to identify prognostic factors that are associated with biochemical failure after definitive external beam radiation therapy. This study included 75 @entity0 with the diagnosis of @entity2 who were referred to four radiation oncology centers in the West Chicago area from 1992 to 1995. All @entity0 were treated with megavoltage external beam radiotherapy to doses between 66 and 70 Gy. Biochemical failure was defined as three consecutive rising PSA values of at least 10% of the prior reading in posttreatment serial measurements. The mean age of the @entity0 was 72 years. The mean follow-up was 1.7 years (range, 1-3 1/2 years). Of the 75 @entity0 , 72 (96%) are clinically with no evidence of disease, three of the 75 are alive with disease, and 60 (80%) remain biochemically free of disease (bNED). The significant factors for bNED status were an initial PSA level of <15 ng/ml (p = 0.0001), achievement of a posttreatment nadir PSA level of < or = 1.5 ng/ml (p = 0.0001), and a Gleason score of <6 (p = 0.034). Multisextant involvement with @entity1 or bilobar disease was not significant. On multivariate analysis, an initial PSA level of <15 ng/ml (p = 0.0001), Gleason score of <6 (p = 0.02), and nadir PSA level of < or = 1.5 ng/ml (p = 0.03) were significant predictors of bNED survival. @entity0 with @entity2 comprise a heterogeneous group. @entity0 with a high PSA level (>15 ng/ml) and high Gleason score (>6) are at increased risk for biochemical failure. Failure to achieve a posttreatment nadir PSA level of < or = 1.5 ng/ml is a predictor of ultimate biochemical failure.

title: Factors that influence biochemical failure after radiation therapy for stage XXXX .

answer: @entity2


abstract: OBJECTIVES/HYPOTHESIS: In order to make possible organ preservation, since 2007 our hospital has performed @entity6 ( @entity6 ) with @entity3 and @entity5 (PF) for @entity1 as chemoselection, followed by alternating chemoradiotherapy (ACRT) with @entity4 , @entity3 , and @entity5 in (TPF) good responders and curative surgery was used in poor responders. METHODS: Twenty-six @entity0 with stage III to stage IVB @entity1 received @entity6 . Eleven of the @entity0 were classified as poor responders and received curative surgery. The remaining 15 @entity0 were classified as good responders. Three of these @entity0 underwent curative surgery, and the remaining 12 underwent ACRT. RESULTS: The primary lesions in the 12 ACRT @entity0 responded completely to treatment without severe late @entity2 . The estimated 3-year laryngectomy-free rate for all 26 @entity0 was 23%. The estimated 3-year overall survival rates for all 26 @entity0 , 12 @entity0 treated with ACRT, and 14 @entity0 who underwent curative surgery, were 79%, 75%, and 84%, respectively. CONCLUSION: The @entity0 who underwent ACRT showed no significant difference in overall survival compared with the @entity0 who underwent curative surgery. All the @entity0 were able to proceed with this series of therapy, indicating that @entity6 with PF could be a feasible tool for choosing good responders. Because ACRT with TPF had a high response rate and fewer severe @entity2 , this treatment could be safe and have enough impact to control @entity1 in good responders. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: Chemoselection combined with alternating chemoradiotherapy or surgery for XXXX .

answer: @entity1


abstract: BACKGROUND: The cognitive fusion questionnaire (CFQ) is a self-report questionnaire that assesses the extent to which individuals are psychologically entangled with, and dominated by the form-content of their thoughts. The aim of this study was to replicate the factor structure of CFQ in @entity3 , @entity1 , @entity2 , @entity4 , and normative population. It further examined the factorial invariance of the CFQ across these 5 groups. METHOD: Data from 299 @entity0 (N General Population   =  67, N @entity3   =  73, N @entity1   =  47, N @entity4   =  45, and N Obesity   =  60) were subjected to confirmatory factorial analysis ( @entity6 ) to replicate the structural model of CFQ dimensionality. RESULTS: @entity6 supported a 1-factor structure with good internal consistency and construct related validity. The 1-factor solution was also supported by a second independent data set, which showed a configural, strict measurement, and structural invariance of the 1-factor solution proposed. Multigroup @entity6 showed the configural invariance, strict measurement invariance, and structural invariance of CFQ across the 5 groups under study. CONCLUSIONS: The unidimensional model has both similar meanings and the same structure, but the measurement model across the groups was not the same. The study provides the first approach to CFQ to Portuguese population, as a reliable tool of general cognitive fusion. Furthermore, results indicated that CFQ has a coherent structure across multiple samples and clinical utility, as it discriminate individuals with @entity5 from those who do not.

title: Validation of the psychometric properties of cognitive fusion questionnaire. A study of the factorial validity and factorial invariance of the measure among @entity3 , @entity1 , XXXX , @entity4 , and general populations.

answer: @entity2


abstract: The @entity3 ( @entity3 ) frequently results in a fibroproliferative response that precludes effective alveolar repair. @entity1 ( @entity6 ), a potent epithelial and mesenchymal cell mitogen, may modulate the response to @entity4 . In this study, we determined whether bronchoalveolar lavage fluid (BALF) concentrations of @entity6 are increased during the first 2 wk after the onset of @entity3 and, if so, whether increased @entity6 levels in lavage fluid are associated with increased levels of procollagen peptide III (PCP III), a biological marker of fibroproliferation, and with increased fatality rates. We enrolled 74 consecutive @entity0 with @entity3 prospectively identified on admission to the intensive care unit of a tertiary care hospital, and 11 @entity0 with chronic @entity2 . Thirteen healthy volunteers served as control subjects. @entity6 concentrations were measured in BALF recovered on Days 3, 7, and 14 after the onset of @entity3 (total of 130 lavage samples). @entity6 was detected in the lavage fluid of 90% of @entity0 with @entity3 (67 of 74), and in 100% of @entity0 with @entity5 ( @entity5 ) (10 of 10), but in none of 13 normal volunteers. At each day tested, the median lavage @entity6 level of @entity0 with @entity3 was significantly higher than that of normals. The overall fatality rate was 45% (33 of 74 @entity0 ). In a univariate analysis, the median @entity6 levels in nonsurvivors were 1.5-fold higher at Day 7 (p = 0.06) and 1.8-fold higher at Day 14 (p = 0.048). The fatality rate was 4 times higher (CI 1.6, 17.5) for @entity0 with both increased lavage @entity6 and PCP III concentrations at Day 7 than for @entity0 with low @entity6 and PCP III values, indicating a synergistic relationship between @entity6 and PCP III. We conclude that increased levels of @entity6 in BALF are common in @entity0 with @entity3 and that lavage @entity6 is associated with a marker of the fibroproliferative response in sustained @entity3 .

title: Elevated XXXX levels in bronchoalveolar lavage fluid of @entity0 with @entity3 .

answer: @entity1


abstract: BACKGROUND: The purpose of this study was to examine the effects of intravenous @entity4 on the duration of @entity2 -induced epidural anaesthesia and level of wakefulness and the respective side-effects. METHODS: Sixty ASA I-II @entity0 were included in the study. Consecutive @entity0 were allocated to groups according to the last digit (odd/even) of their admission numbers. All @entity0 had epidural anaesthesia with @entity2 0.5% performed by the same experienced anaesthesiologist. In the first group, the @entity0 were administered intravenous @entity4 infusion just after the epidural block and continued during the operation, while those in the second group were administered physiologic saline infusion at the same amount and duration. RESULTS: The recovery time of sensory block was significantly longer in the first group. The bispectral index values were lower in the first group than in the second. Also, heart rate was significantly lower in Group I than in Group II. Regarding side-effects, shivering was significantly less frequent in the first group, whereas there was a significant increase in the requirement of @entity3 in the first group as @entity4 caused @entity1 . CONCLUSION: Intravenous administration of @entity4 prolonged the duration of epidural anaesthesia, provided sedation and had few side-effects.

title: Effects of @entity4 on the duration of anaesthesia and wakefulness in XXXX epidural block.

answer: @entity2


abstract: UNASSIGNED: A 44-year-old male with no pertinent history other than poor vision for more than 25 years was examined. Best corrected visual acuity was 20/80 OD [MR: +14.25 +1.00   *   15  ] and 20/200 OS [MR: +15.00 +1.50   *   175  ]. Significant limitation in ocular movements and the presence of an orbital lipodermoid in the infero-temporal aspect of each eye were noted. Forced duction test was positive for the same directions of limitation indicating possible extraocular muscle @entity1 . Ophthalmoscopy was remarkable for the presence of peripheral bony spicules. Corneal topography was compatible with @entity4 (Kmax   =   55.04D OD and 52.87D OS). A-scan revealed axial lengths of 16.96   mm OD and 16.32   mm OS, compatible with a diagnosis of @entity2 . @entity3 revealed diffuse macular thickening for both eyes with foveal thickness of 350     m OD and 353     m OS. Over the next 12 years the @entity0 had stable visual acuity, manifest refractions and anterior segment examination. Ophthalmoscopy revealed only minimal progression of pigmentary changes. We report the first case of these simultaneous multiple findings which may refer to a possible syndromic association of congenital or early childhood onset.

title: A @entity0 with XXXX , Nanophthalmos, Lipodermoids, and Pigmentary Retinopathy.

answer: @entity4


abstract: OBJECTIVE: The objective of this study was to determine the efficacy of percutaneous radiofrequency (RF) thermocoagulation of the ramus communicans nerve in @entity0 suffering from @entity3 . METHODS: Forty-nine @entity0 who suffered @entity3 at only 1 painful vertebral level, and whose @entity1 continued after undergoing intradiscal electrothermal annuloplasty (IDET), were randomly assigned to 1 of 2 treatment groups. The lesion group (n = 26) received RF thermocoagulation of the ramus communicans nerve. @entity0 in the control group (n = 23) received an injection of @entity4 without radiofrequency. Visual analog scale (VAS) @entity1 scores, analgesic requirements, SF-36 subscales, and the overall @entity0 satisfaction with the procedure were tabulated. RESULTS: The average follow-up period was 4 months. The @entity0 -reported VAS @entity1 scores were significantly lower (P < 0.05) in the lesion group. The scores of the RF lesion group improved by a mean increase of 11.3 points (P < 0.05) on the SF-36 bodily @entity1 subscale, and by a mean increase of 12.4 points on the physical function subscale (P < 0.05). In a follow-up analysis within the RF lesion group, VAS @entity1 scores improved by a mean reduction of 3.32 (P = 0.001). The scores improved by a mean increase of 14.5 points (P = 0.005) on the SF-36 bodily @entity1 subscale and 15.2 points(P = 0.002) on the physical function subscale within the RF lesion group. One @entity0 in the lesion group complained of mild @entity2 , but he completely recovered at postoperative 15 days without any serious problems. DISCUSSION: In @entity0 with @entity3 , percutaneous RF denervation of the ramus communicans nerve should be considered as a treatment option.

title: A randomized controlled trial of radiofrequency denervation of the ramus communicans nerve for XXXX .

answer: @entity3


abstract: AIM: To study the frequency of borderline @entity1 in @entity0 of secondary general education schools. MATERIAL AND METHODS: We examined 1013 male and female schoolchildren, aged 12-14 and 15-17 years. In the first stage, the they completed a screening questionnaire to estimate the presence of a range of @entity5 . An analysis of medical history and clinical examination were performed as well. The second stage included medical examination using DAWBA for the @entity0 with total scores on The Strengths and Difficulty questionnaire >= 16; with the score >= 6 on the emotional scale and with the score  <=5 on the social scale. RESULTS AND CONCLUSION: Generalized anxiety and @entity2 were recorded more often in @entity0 than in @entity0 . Every 4-th adolescent (26.1%), regardless of gender, had problems in communication with peers. At the same time, @entity0 showed conduct disturbances more often (p=0.005) than @entity0 (23.3% and 16.3%, respectively). @entity2 was 6,1 times more frequent in adolescents of the older group as compared with younger @entity0 (  =0.024). @entity2 was associated with @entity4 (68.6% of @entity0 , mostly in @entity0 and in the older group), @entity3 (37.3%, mostly in @entity0 ) and back pain (39.2%).

title: [Borderline XXXX in schoolchildren].

answer: @entity1


abstract: UNASSIGNED: The combination of @entity10 , @entity3 and @entity9 (MPT) is considered standard therapy for newly diagnosed @entity0 with @entity6 (NDMM) who are ineligible for stem-cell transplantation. Long term treatment with @entity9 is hampered by @entity8 . @entity10 , @entity3 and @entity11 , followed by @entity11 maintenance therapy showed promising results, without severe @entity1 emerging. We randomly assigned 668 NDMM @entity0 , ineligible for stem-cell transplantation, between nine 4-weekly cycles of MPT followed by @entity9 maintenance until disease progression or unacceptable @entity2 ( @entity7 ) and the same MP regimen with @entity9 being replaced by @entity11 (MPR-R). This multicenter, open-label, randomised phase 3 trial was undertaken by HOVON and the NMSG. The primary endpoint was progression-free survival (PFS). The accrual for the study was completed in October 19, 2012. 318 @entity0 were randomly assigned to receive @entity7 and 319 MPR-R. After a median follow up of 36 months PFS with @entity7 was 20 months (95% CI 18-23 months) versus 23 months (95% CI 19-27 months) with MPR-R (HR 0.87 [0.72-1.04], p=0.12). Response rates were similar, with >= VGPR 47% and 45% respectively. @entity5 was more pronounced with MPR-R, especially grade 3 and 4 @entity4 : 64 versus 27%. Neuropathy >=  grade 3 was significantly higher in the @entity7 arm; 16% versus 2% in MPR-R, resulting in a significant shorter duration of maintenance therapy (5 versus 17 months in MPR-R), irrespective of age. MPR-R has no advantage over @entity7 concerning efficacy. The @entity2 profile differed with clinically significant @entity1 during @entity9 maintenance versus myelosuppression with MPR.

title: @entity11 plus @entity10 and @entity3 , followed by @entity11 maintenance versus XXXX plus @entity10 and @entity3 , followed by @entity9 maintenance; results of the randomised phase 3 HOVON 87/NMSG18 trial.

answer: @entity9


abstract: PURPOSE: To outline the clinical characteristics of @entity4 in our large series of @entity2 ( @entity2 ) @entity0 with neurologic involvement. METHODS: All files of 223 @entity0 with neuro- @entity2 were evaluated retrospectively, and the group with clearly documented @entity4 was included in the current study. Clinical characteristics, EEG, neuroimaging and cerebrospinal fluid findings were reevaluated, and the @entity4 were classified according to the new proposed criteria of the International League Against @entity3 . On excluding the @entity0 in whom the @entity4 were due to possible @entity4 -provoking factors, the @entity4 that appeared during a neurologic exacerbation were noted. RESULTS: @entity4 were seen in 10 (4.48%) of 223 @entity0 . There were one female and nine male @entity0 . In five of the @entity0 , @entity4 occurred during neurologic exacerbation. Therefore, the actual prevalence of @entity4 due to @entity2 in our group is 2.2%. In the remaining five @entity0 , the @entity4 were not related to @entity1 attacks, but probably were due to some @entity4 -provoking factors. The predominating @entity4 type was generalized tonic-clonic @entity4 accompanied by @entity4 . It is notable that four @entity0 died 1-5 years after the onset of the @entity4 . CONCLUSIONS: Our study showed that @entity4 are rare in @entity2 . As the @entity4 due to some interventions and drugs are as frequent as neuro- @entity2 -related @entity4 , @entity4 -provoking factors must be considered before attributing them to the pathogenetic mechanism of @entity2 . The occurrence of @entity4 seems to be associated with a high mortality rate.

title: @entity3 in XXXX .

answer: @entity2


abstract: OBJECTIVE: A phase II study was conducted to determine the efficacy of @entity7 therapy in @entity0 with previously treated @entity9 . METHODS: Eligible @entity0 were to have measurable disease and not more than one prior chemotherapy regimen that could include @entity11 or @entity6 but not @entity7 . @entity7 130 mg/m(2) was administered intravenously over 2 h. This treatment was repeated every 21 days until progression of disease or adverse effects prohibited further therapy. RESULTS: Twenty-eight @entity0 were entered onto this study, of whom 24 were evaluable for @entity2 and 22 were evaluable for response; 23/24 evaluable @entity0 had had prior @entity8 . There were two (8.3%) responses. One @entity0 achieved a complete response which lasted 2.2 months, and a second @entity0 attained a partial response which lasted 3.2 months. Nine (37.5%) @entity0 had stable disease with a median duration of 7.6+ (3.1-21.2) months. The most frequently reported drug-related @entity2 consisted of @entity5 , @entity3 and @entity4 , and @entity10 . Three (12.5%) @entity0 had a grade 3 @entity1 response that was infusion-related and was largely resolved by increasing infusion time. CONCLUSIONS: @entity7 has limited activity in @entity0 with persistent or recurrent @entity9 at the dose and schedule tested.

title: Phase II evaluation of @entity7 in previously treated XXXX : a gynecologic oncology group study.

answer: @entity9


abstract: OBJECTIVE: This study was undertaken to examine both isolated and concomitant @entity1 to clarify the role of liver @entity2 on outcome. @entity0 AND METHODS: This retrospective study was a review of all @entity5 @entity0 who presented with @entity1 , with or without concomitant injury at Ege University School of Medicine over a 3-year period. Presentation, injury grade, management, and outcomes were analyzed. @entity0 with isolated @entity1 (Group A) were compared with @entity0 who had concomitant @entity1 (liver and spleen/small bowel) (Group B). Significance was set at 95% confidence intervals. RESULTS: Of 368 @entity0 , 80 (21%) presented with @entity1 . Of these, the aetiology was as follows: 53 (66.2%) @entity6 , 19 (23%) penetrating injury, and 8 (10%) gun shot @entity2 . There were 38 @entity0 in Group A and 42 in Group B. Of these 42 @entity0 , 19 were diagnosed with serious @entity2 ; eight thoracic, three open long bone @entity3 , one intra-cardiac, one intracranial. Six additional @entity0 were observed with injuries to large abdominal vessels. Eleven @entity0 (28.9%) with isolated @entity1 were managed non-operatively. Mortality, intensive care unit and hospital length of stay, and transfusion requirements were significantly higher in Group B. Only the number of transfused blood units and the grade of @entity1 were found to be effective on outcome whereas stepwise regression analysis revealed that @entity2 (penetrating) and blood transfusion were predictive for mortality. CONCLUSION: This study highlighted that although isolated @entity1 results in good outcome with non-operative management, concomitant injuries to the liver lead to a higher failure and mortality rate. However, @entity1 itself is rarely responsible for @entity4 .

title: Comparison of isolated and concomitant @entity1 : is XXXX entirely responsible for the outcome?

answer: @entity1


abstract: OBJECTIVES: The goal of this study was to investigate the hemodynamic and circulatory adjustments to extracorporeal ultrafiltration (UF) in refractory congestive @entity4 (rCHF). BACKGROUND: In rCHF, UF allows clinical improvement and restores diuretic efficacy. However, in the course of a UF session, @entity0 are exposed to rapid variations of body fluid composition so that, as fluid is withdrawn from the intravascular compartment, @entity3 or even shock could occur. METHODS: In 24 @entity0 with rCHF undergoing UF, we measured, after every liter of plasma water removed, hemodynamics, blood gas analysis (in both @entity2 ), plasma volume changes (PV) and plasma refilling rate (PRR). The PV and PRR were calculated by considering hematocrit and ultrafiltrate volume. RESULTS: In all @entity0 , UF was performed safely, without side effects or hemodynamic instability (ultrafiltrate = 4,880 +/- 896 ml). Mean right @entity2 and wedge pressures progressively reduced during the procedure. Cardiac output increased at the end of the procedure and, to a greater extent, 24 h later, in relation to the increase of @entity1 volume. Heart rate and systemic vascular resistance did not increase, and other peripheral biochemical parameters did not worsen during UF. Intravascular volume remained stable throughout the entire duration of the procedure, indicating that a proportional volume of fluid was refilled from the congested parenchyma. CONCLUSIONS: In @entity0 with rCHF, subtraction of plasma water by UF is associated with hemodynamic improvement. Fluid refilling from the overhydrated interstitium is the major compensatory mechanism for intravascular fluid removal, and @entity3 does not occur when plasma refilling rate is adequate to prevent @entity5 .

title: Circulatory response to fluid overload removal by extracorporeal ultrafiltration in refractory congestive XXXX .

answer: @entity4


abstract: UNASSIGNED: Chromosome rearrangement is clinically and physiologically important because it can produce oncogenic fusion genes. Chromosome rearrangement requires DNA double-strand breaks (DSBs) at two genomic locations and misrejoining between the DSBs. Before DSB misrejoining, two DSB-containing chromatin regions move and pair with each other; however, the molecular mechanism underlying this process is largely unknown. We performed a spatiotemporal analysis of ionizing radiation-induced foci of @entity2 ( @entity2 ), a marker for DSB-containing chromatin. We found that some @entity2 foci were paired, indicating that the two damaged chromatin regions neighboured one another. We searched for factors regulating the foci pairing and found that the number of paired foci increased when @entity0 , @entity1 , or ATM was absent. In contrast, @entity2 depletion reduced the number of paired foci and dicentric chromosomes-an interchromosomal rearrangement. Foci were paired more frequently in heterochromatin than in euchromatin in control cells. Additionally, the reduced foci pairing in @entity2 -depleted cells was rescued by concomitant depletion of a heterochromatin building factor such as Kr  ppel-associated box-associated protein 1 or @entity3 . These findings indicate that pairing between DSB-containing chromatin regions was suppressed by @entity0 , @entity1 , and ATM, and this pairing was promoted by @entity2 through chromatin relaxation.

title: Regulation of pairing between broken DNA-containing chromatin regions by @entity0 , XXXX , ATM, and 53BP1.

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity4 ) remains the most common cause of @entity2 worldwide. @entity0 presenting with advanced-stage @entity4 have poor prognosis, while metastatic spread accounts for >70  % of @entity0 's deaths. The major advances in the treatment of @entity1 have brought only minor improvements in survival; therefore, novel strategic treatment approaches are urgently needed. Accumulating data allocate a central role for the @entity2 microenvironment including mesenchymal stem cells (MSCs) in acquisition of drug resistance and disease relapse. Furthermore, studies indicate that translation initiation factors are over expressed in @entity4 and negatively impact its prognosis. Importantly, translation initiation is highly modulated by microenvironmental cues. Therefore, we decided to examine the effect of bone marrow MSCs (BM-MSCs) from normal donors on @entity4 cell lines with special emphasis on translation initiation mechanism in the crosstalk. We cultured @entity4 cell lines with BM-MSC conditioned media (i.e., secretome) and showed deleterious effects on the cells' proliferation, viability, @entity3 , and migration. We also demonstrated reduced levels of translation initiation factors implicated in @entity2 progression [ @entity5 ( @entity5 ) and @entity6 ( @entity6 )], their targets, and regulators. Finally, we outlined a mechanism by which BM-MSCs' secretome affected @entity4 's mitogen-activated protein kinase (MAPK) signaling pathway, downregulated the cell migration, and diminished translation initiation factors' levels. Taken together, our study demonstrates that there is direct dialogue between the BM-MSCs' secretome and @entity4 cells that manipulates translation initiation and critically affects cell fate. We suggest that therapeutic approach that will sabotage this dialogue, especially in the BM microenvironment, may diminish @entity1 metastatic spread and morbidity and improve the @entity0 's life quality.

title: Secretome of XXXX bone marrow mesenchymal stem cells: an emerging @entity1 progression and mechanisms of translation initiation.

answer: @entity0


abstract: OBJECTIVES: @entity2 caused by uropathogenic @entity3 (UPEC) strains is one of the most important infections in the world. UPEC encode widespread virulence factors closely related with pathogenesis of the bacteria. The purpose of this study was to evaluate the presence of different phenotypic virulence markers in UPEC isolates and determine their correlation with antibiotic resistance pattern. METHODS: UPEC isolates from @entity0 with different clinical symptoms of UTI were collected and screened for biofilm and hemolysin production, @entity8 resistant, and @entity8 sensitive hemagglutination (MRHA and MSHA, respectively). In addition, antimicrobial resistance pattern and ESBL-producing isolates were recorded. RESULTS: Of the 156 UPEC isolates, biofilm and hemolysin formation was seen in 133 (85.3%) and 53 (34%) isolates, respectively. Moreover, 98 (62.8%) and 58 (37.2%) isolates showed the presence of Types 1 fimbriae (MSHA) and P fimbriae (MRHA), respectively. Our results also showed a relationship between biofilm formation in UPEC isolated from acute @entity7 @entity0 and recurrent UTI cases. Occurrence of UTI was dramatically correlated with the @entity0 ' profiles. We observed that the difference in antimicrobial susceptibilities of the biofilm and nonbiofilm former isolates was statistically significant. The UPEC isolates showed the highest resistance to @entity6 , @entity5 , @entity1 , and @entity4 . Moreover, 26.9% of isolates were ESBL producers. CONCLUSION: This study indicated that there is a relationship between the phenotypic virulence traits of the UPEC isolates, @entity0 ' profiles, and antibiotic resistance. Detection of the phenotypic virulence factors could help to improve understanding of pathogenesis of UPEC isolates and better medical intervention.

title: Phenotypic Assays to Determine Virulence Factors of Uropathogenic XXXX (UPEC) Isolates and their Correlation with Antibiotic Resistance Pattern.

answer: @entity3


abstract: UNASSIGNED: The purpose of this study is to compare the @entity2 and the amblyopic eyes using enhanced depth imaging optical coherence tomography (EDI-OCT) in young Turkish adults with hyperopic @entity3 . @entity0 with unilateral hyperopic @entity3 were enrolled and underwent a full ophthalmological assessment, including best-corrected visual acuity, cycloplegic refraction, and axial length (AL) measurements. Cirrus EDI-OCT was used to obtain subfoveal CT, GCC thickness, retinal nerve fiber layer (RNFL), and central macular thickness (CMT) measurements. Comparison was performed between the amblyopic eyes and the normal fellow eyes. Forty-three hyperopic anisometropic amblyopic @entity0 were enrolled in this study. Mean age of 23 female and 20 male @entity0 was 24.8      7.4  years. Mean AL was 21.9      1.3 and 22.4      0.9  mm in amblyopic and fellow eyes, respectively (P  <  0.05). Mean subfoveal CT measurements were 325.4      44.2 and 317.9      42.7     in amblyopic and fellow eyes, respectively. There was no statistically significant difference between the groups (P  >  0.05). Mean GCC thickness was 83.8      3.6     in amblyopic eyes and 83.5      3.9     in the fellow eyes. Statistically significant difference was not seen between the groups (P  >  0.05). Mean RNFL and mean CMT measurements were also similar in two groups (P  >  0.05). Subfoveal CT, CMT, RNFL, and GCC thickness measurements were not statistically significant between @entity1 .

title: Evaluation of the retinal ganglion cell and choroidal thickness in young Turkish adults with hyperopic XXXX .

answer: @entity3


abstract: OBJECTIVE: To study effects of autogenous femoral head bone grafting combined with total hip replacement for the treatment of old center dislocation of @entity3 , and to evaluate the superiority of acetabular defect reconstruction with autogenous bone. METHODS: From March 2008 to December 2013, 16 @entity0 (16 hips) with old center dislocation of @entity3 were treated with autologous bone graft combined with total hip replacement. There were 11 males and 5 females, ranging in age from 41 to 72 years old, with an average of 56.3 years old. The duration of the disease ranged from 3.6 to 37.2 years. Twelve @entity0 had @entity1 caused by traffic accidents and 4 @entity0 were caused by falling down. The @entity3 @entity2 at the first month after operation, Harris score and @entity3 movement of all @entity0 were observed by using electronic case follow-up system. RESULTS: All the @entity0 were followed up, and the duration ranged from 11 to 78 months, with an average of 27.3 months. The postoperative @entity3 movement of (56.2  23.4)   VAS 86.3  7.2 and Harris score 32.6  12.6 were all better than preoperative (181.8  17.6)  , 11.1  2.6 and 86.3  7.2. The joint @entity2 was reduced and the function limitation was improved after operation, and the prosthesis position was good. CONCLUSION: When the autologous femoral head bone grafting combined with total hip arthroplasty is used to treat old @entity3 , the initial and long-term stability of acetabular bone grafting is good, and the technique can avoid allogeneic bone complications, bone source rationally and reduce the economic burden of @entity0 .

title: [Autogenous femoral head bone grafting combined with total hip arthroplasty for the treatment of old dislocation of XXXX in 16 cases].

answer: @entity3


abstract: BACKGROUND: Values of hematological parameters are affected by factors such as age, sex, ethnic background and social, nutritional and environmental factors. The objective of this study was to determine the values of hematological parameters, red cell indices and @entity1 and Hb F levels in normal Saudi @entity0 , living in the Central Province of Saudi Arabia. MATERIALS AND METHODS: The study was carried out on 1526 apparently healthy @entity0 , with ages ranging from 1-15 years, and selected during a household screening program. Hematological parameters, red cell indices, and hemoglobin types ( @entity1 and Hb F) were estimated, and the @entity0 were divided into 15 groups depending on the age. Male and female @entity0 were separated, and the mean and standard deviation of each parameter was calculated for each age group. RESULTS: No significant differences were observed in the red cell count in the male and female @entity0 . White blood cells gradually decreased from 2 years onwards, while hemoglobin and hematocrit levels increased significantly from 2 to 15 years. Mean cell volume and mean cell hemoglobin also showed slight increases, while mean cell hemoglobin concentration remained more or less constant. Hemoglobin A2 and Hb F showed slight but nonsignificant fluctuations. Comparison of the results with those reported in the literature shows that Saudi @entity0 have some values similar to Caucasians, while others have values which are intermediate between Caucasians and African @entity0 . CONCLUSION: The values reported in this study can be used as normal reference values for Saudi @entity0 and adolescents.

title: Normal reference values for hematological parameters, red cell indices, XXXX and HB F from early childhood through adolescence in Saudis.

answer: @entity1


abstract: PURPOSE: Bevacizumab has demonstrated survival benefit in metastatic @entity1 (mCRC) @entity0 when combined with chemotherapy. Several randomized clinical studies have evaluated bevacizumab in combination with chemotherapy. Meta-analysis was performed to better assess the efficacy and safety of bevacizumab with chemotherapy for mCRC. MATERIALS AND METHODS: Five clinical trials randomizing a total of 3,103 mCRC @entity0 to chemotherapy alone or to the combined treatment of chemotherapy plus bevacizumab were identified. The efficacy data included progression-free survival (PFS), overall survival (OS), and overall response rate (ORR), and the safety data contained the 60-day all-cause mortality rate, adverse events (AEs), and specific @entity3 such as @entity2 , @entity8 , @entity6 , @entity7 , @entity5 , @entity4 , and @entity10 . RESULT: There was a significant PFS benefit (P = 0.00; hazards ratio [HR] = 0.66) and OS benefit (P = 0.00; HR = 0.77) in favor of the combined treatment. The ORR was significantly higher on the bevacizumab-containing arm (P = 0.021; relative risk [RR] = 1.5), while CR was comparable between the two arms (P = 0.09). A higher incidence of grade 3/4 AEs, grade 3/4 @entity2 , grade 3/4 @entity9 /thrombotic events, grade 3/4 @entity6 , and @entity5 was associated with the bevacizumab group. The two treatment groups were similar in terms of grade 3/4 @entity7 , grade 3/4 @entity11 , grade 3/4 @entity4 , and the 60-day all-cause mortality rate. CONCLUSION: The addition of bevacizumab to chemotherapy confers a clinically meaningful and statistically significant improvement in OS, PFS, and ORR. Its side effects are predictable and manageable and do not compound the incidence or severity of @entity3 from chemotherapy.

title: A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic XXXX .

answer: @entity1


abstract: BACKGROUND: Denovo @entity2 ( @entity2 ) develops in 5% to 10% of @entity0 after ileal pouch-anal @entity5 (IPAA) for @entity3 ( @entity3 ) leading to increased morbidity and rates of pouch failure. Initial nonbloody @entity7 and @entity8 at diagnosis are independent risk factors for a change in diagnosis from @entity3 to @entity2 in nonsurgical @entity0 . We investigated whether these features were risk factors for denovo @entity2 in a longitudinal cohort of @entity0 with @entity3 undergoing IPAA. METHODS: Prospective profiles of @entity0 with @entity3 undergoing IPAA followed over a 22-year period by 1 surgeon were analyzed. Denovo @entity2 was diagnosed when @entity4 (5 or more @entity9 ) involved the small bowel mucosa proximal to the ileal pouch any time after surgery and/or when a pouch @entity6 or other perianal complication developed more than 3 months after ileostomy closure. @entity0 with @entity1 unclassified, acute @entity10 , chronic @entity10 , and those lost to follow-up were excluded from analysis. Cox regression analysis was performed for statistical significance. RESULTS: Of the 199 study @entity0 included in the analysis, denovo @entity2 developed in 42 @entity0 (21%). @entity0 who developed denovo @entity2 had an increased incidence of nonbloody @entity7 (n = 12; 29%) compared with @entity0 who had no evidence of pouch @entity4 (n = 25; 16%) (P = 0.03). In contrast, the incidence of @entity8 was not significantly increased in @entity0 with denovo @entity2 (n = 7; 17%) compared with @entity0 who never had pouch @entity4 (n = 16; 10%) (P = 0.12). CONCLUSIONS: Initial nonbloody @entity7 is associated with denovo @entity2 after IPAA. This association warrants close consideration before surgery.

title: Nonbloody @entity7 but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo @entity2 After Ileal Pouch-anal XXXX for @entity3 .

answer: @entity5


abstract: @entity5 in @entity6 is caused by a variety of central nervous system (CNS) lesions, of which the molecular and pathogenic causes are poorly understood but probably include: 1. @entity7 in dopaminergic, noradrenergic, serotonergic, cholinergic or multiple systems including the amygdyloid nucleus; 2. limbic and/or cortical @entity4 and/or Lewy body pathologies, with loss of synapses and neurons, and 3. a combination of these lesions or additional CNS pathologies. In general, degeneration of subcortical @entity7 appears insufficient to induce severe mental decline although, occasionally, @entity1 occurs without apparent @entity2 . On the other hand, neuritic cortical @entity4 showing similar or differential distribution compared to @entity4 ( @entity4 ) displays a significant linear correlation with @entity5 in @entity6 . Plaques can be associated with cortical Lewy bodies and, the contribution of each to dementing processes remains unresolved. In a consecutive autopsy series of 610 @entity0 with @entity6 , the total prevalence of retrospectively assessed @entity5 was 34.6%. In @entity3 ( @entity3 ) of the Lewy body type, it was 30.2%, mostly associated with other @entity2 , mainly @entity4 , while only 3.5% of "pure" @entity3 without additional brain pathologies were demented. There was no significant difference in age and duration of illness between demented and non- @entity3 @entity0 . Secondary @entity3 showed a higher incidence of @entity5 (56.3%), again with predominant @entity4 which was present in 73% of the total of demented @entity3 @entity0 and in almost 82% of the @entity3 cases in this series. The specific contribution of cortical and @entity2 to @entity1 in @entity6 , their relationship to @entity4 , and an etiology await further elucidation.

title: Morphological substrates of @entity5 in XXXX . A critical update.

answer: @entity6


abstract: The reproductive success of wild birds has been affected by exposure to multiple contaminants. Reproduction of captive @entity2 ( @entity2 ) was suppressed when adult birds were exposed to dietary @entity0 ( @entity0 ). In this study, the reproductive effects of in ovo exposure to @entity0 is explored, along with determining effects on reproduction in second-generation birds indirectly exposed to @entity0 . Reproductive changes in this subsequent generation are examined separately in male and female birds. Captive @entity2 (F. sparerius) were hatched from clutches with eggs containing environmentally relevant levels of total @entity0 (34.0 microg/g whole egg WW versus 0 microg/g controls); parent birds had been fed @entity1 -spiked (Aroclor 1248:1254:1260) food (7 mg/kg BW day(-1)) for 100 days until their eggs hatched. In 1999, the second-generation @entity1 birds were paired with unexposed kestrels having reproductive experience. In ovo @entity1 exposure suppressed egg laying completely in 25% of @entity1 females and resulted in delays in clutch initiation and smaller clutch sizes for @entity1 male and female pairs. There was no evidence in this study of in ovo @entity1 treatment effects on fertility or hatching success. The decline in reproductive success was also reflected in the reduced fledging success and higher incidence of complete brood mortality of @entity1 nestlings. Differences between in ovo-exposed @entity1 males and females but not between controls were evident in reproductive success. In ovo @entity1 exposure appears to have had greater effects on female kestrels until clutch completion, with a greater time lag between pairing and egg laying, reduced numbers of pairs laying eggs, and smaller clutches being laid. In ovo @entity1 exposure has greater effects later in the breeding season on male kestrels, which had poorer hatching and fledging success relative to the @entity1 females. Possible behavioral and physiological mechanisms involved in these reproductive changes are discussed.

title: In ovo exposure to XXXX : reproductive effects on second-generation @entity2 .

answer: @entity0


abstract: BACKGROUND: There are a wide range of drugs including antidepressants, anticonvulsants and antipsychotics that cause embryonic @entity3 in vitro but it is unknown if they have a similar effect in vivo. One way to verify whether these in vitro findings are replicated in vivo is by the use of ultrasound examination of dosed pregnant @entity1 . We tested this by examining the effect of @entity5 on embryonic heart rate (HR) in vivo using ultrasound. METHODS: @entity1 were dosed with @entity5 (4 or 2.5 mg/kg) on GD11 or (5 or 2.5 mg/kg) on GD13 and embryonic HR assessed by ultrasound, 2 and 24 hr later. Fetuses were examined for @entity2 on GD20. RESULTS: HR of control @entity1 embryos showed a wide range at each gestational day. Dosing with @entity5 on GD11 caused severe @entity3 (   60% reduction) 2 hours after dosing with recovery after 24 h of >60% of LD but death and slow HR among the @entity4 embryos. At term, 32% of the LD surviving fetuses had hypoplastic upper lip while >90% of @entity4 embryos had died. On GD13, embryonic HR was reduced in a dose-dependent manner with >85% of LD and @entity4 recovered by 24 hr. At term, all LD fetuses were normal while 29% of @entity4 fetuses had @entity6 . CONCLUSIONS: Ultrasound is a useful technique to investigate the effect of maternally administered drugs on the embryonic HR in the @entity1 . The results may provide more information about the safety of these drugs in pregnancy leading to better risk assessment for the @entity0 .

title: The Effect of XXXX on the Heart Rate of GD11 and GD13 @entity1 Embryos, in vivo, Using Ultrasound.

answer: @entity5


abstract: PURPOSE: Our aim was to evaluate the safety and efficacy of percutaneous nephrolithotomy (PCNL) with ultrasonography (US)-guided renal access in the @entity2 . @entity0 AND METHODS: From July 2006 to March 2008, 40 @entity0 with @entity3 > 2 cm underwent PCNL with US-guided renal access in the @entity2 by a single surgeon. We report our technique and the outcomes in detail. RESULTS: Successful access was achieved in 40 @entity0 (100%). Complete stone clearance rate was 85% (34 @entity0 ). After surgery, six (15%) @entity0 had stones (6-11 mm) detected by plain abdominal radiography or sonography and were referred for shockwave lithotripsy. The mean stone size was 29 mm (range 22-43 mm). The mean operative time was 45 minutes (range 32-75 min), and the mean hospital stay was 2.8 days (range 2-4 d). Postoperative US did not reveal considerable fluid collection. There were no visceral injuries. Also, there was no significant @entity1 that led to transfusion intraoperatively and postoperatively. CONCLUSION: PCNL with US-guided renal access in the @entity2 is safe and convenient, and prevents harmful effects of radiation for the surgeon, the surgical team, and the @entity0 .

title: Percutaneous nephrolithotomy with ultrasonography-guided renal access in the XXXX .

answer: @entity2


abstract: OBJECTIVES: To evaluate the additional analgesic efficacy of the rectal administration of @entity3 suppository compared with placebo in @entity0 undergoing transrectal ultrasound-guided prostate biopsy. METHODS: A total of 40 consecutive @entity0 undergoing biopsy were enrolled in this study. @entity0 were randomized equally into two treatment groups. In group 1, @entity0 received an intrarectal 100-mg @entity3 suppository 1 hour before biopsy. In group 2, @entity0 received a glycerin suppository as a placebo intrarectally 1 hour before biopsy. All @entity0 received 10 mL of 2% @entity2 gel intrarectally 10 minutes before biopsy. A self-administrated visual analog scale was used to measure the @entity1 scores at the end of the biopsy and 2 hours and 1 day after the biopsy. RESULTS: The mean @entity0 age was 63.3 +/- 6.8 years and 61.6 +/- 6.7 years in groups 1 and 2, respectively. The mean @entity1 score in groups 1 and 2 was 3.4 +/- 1.3 versus 5.9 +/- 1.7 (P < 0.0001), respectively, at the end of the biopsy. The mean @entity1 score at 2 hours and 1 day after the procedure was 1.2 +/- 1.0 versus 3.6 +/- 1.4 (P < 0.0001) and 0.5 +/- 0.9 versus 1.4 +/- 1.3 (P = 0.017) in groups 1 and 2, respectively. CONCLUSIONS: Intrarectal @entity3 suppository administration is a simple, safe, and effective procedure to reduce @entity1 and improve @entity0 ' tolerance of transrectal ultrasound-guided prostate biopsy. We recommend intrarectal @entity3 suppository administration, together with intrarectally administered @entity2 gel, in @entity0 undergoing transrectal ultrasound-guided prostate biopsy.

title: @entity3 suppository administration in conjunction with XXXX gel during transrectal ultrasound-guided prostate biopsy: prospective, randomized, placebo-controlled study.

answer: @entity2


abstract: @entity2 is one of the few remaining hormonal insufficiency states for which replacement therapy is unavailable. Previous short-term controlled trials have shown @entity4 to be a safe and effective treatment of @entity2 . In this randomized, parallel group, open-label trial, we compared synthetic @entity0 @entity4 -(1-34) ( @entity4 ) with conventional therapy, @entity6 and @entity3 , over a 3-yr period. Twenty-seven @entity0 with confirmed @entity2 , aged 18-70 yr, were randomized to either twice daily sc @entity4 or oral @entity6 and @entity3 . The primary end points were @entity3 levels in serum and urine. Secondary end points were @entity5 clearance, markers of @entity1 , and bone mineral density. Throughout the 3-yr study period, serum @entity3 levels were similar in both treatment groups within or just below the normal range. Mean urinary @entity3 excretion was within the normal range from 1-3 yr in @entity4 -treated @entity0 , but remained above normal in the @entity6 group. Bone mineral content and bone mineral density showed no significant between-group differences over the 3-yr study period. We conclude that treatment with twice daily sc @entity4 provides a safe and effective alternative to @entity6 therapy and is able to maintain normal serum @entity3 levels without @entity7 for at least 3 yr in @entity0 with @entity2 .

title: Long-term treatment of @entity2 : a randomized controlled study comparing parathyroid hormone-(1-34) versus XXXX and @entity3 .

answer: @entity6


abstract: PURPOSE: To assess the upper eyelid kinematics during spontaneous blinking in unilateral @entity4 before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN: Comparative case series. SUBJECTS: @entity0 with long-standing unresolved unilateral @entity3 who underwent surgical treatment with GW (n   =   8) or upper lid cerclage with TF (n   =   10). The contralateral eyelid served as the control for each @entity0 (control group). METHODS: Preoperative and postoperative measurements of spontaneous blink kinematics with magnetic search coil and clinical assessment of lid margin position, lagophthalmos and ocular surface exposure, and determine amplitude, maximum velocity and main sequence of spontaneous blinks; relative amplitude of blinks to the pupil center; ocular surface exposure scores; magnitude of lagophthalmos and mid-pupil lid distances. RESULTS: The mean (  SE) down-phase amplitude ratio between paralyzed and contralateral eyelids ( @entity1 ) was 10.0% preoperatively for both groups and significantly increased to 29        6% for the GW group (p   <   0.05) and 23        4% for the TF group (p   <   0.05). At 6 months the gain was significant for the GW group only (32        7%, p   <   0.05). There was no effect on the maximum velocity of the blinks or the main sequence of paretic and contralateral blinks with either surgery. Both procedures lowered the lid margin increasing the number of blinks that reached the pupil center. At 6 months this effect was prominent only for the GW group. @entity2 scores and lagophthalmos decreased postoperatively especially in the GW group. CONCLUSIONS: The beneficial effect of lid load surgeries result from a combination of a small increase on the spontaneous blink amplitude and a static effect due to the reduction of the distance between the lid margin and pupil center.

title: Spontaneous Blinking Kinetics on XXXX After Lid Load with Gold Weight or Autogenous Temporalis Fascia Sling.

answer: @entity4


abstract: Increased @entity2 is a hallmark of early @entity5 , whereas the role of immunoglobulins (Igs), such as IgG (its 1-4 subtypes), IgA, and IgM, different in charge and size, has not been examined in early @entity0 in the past due to lack of a sensitive and reliable method. Our study group consisted of subjects with @entity4 ( @entity4 ) and normoalbuminuria (n = 78), microalbuminuria (n = 78), and of 75 @entity1 ( @entity1 ). A Luminex-based immunoassay (1,000 time more sensitive than nephelometry-based method) was validated for the urine matrix and used for the measurements of IgG1-4, IgA, and IgM in our study groups. The Luminex-based assay detected Igs in 87% of @entity1 subjects and in 100% of @entity4 subjects. Recovery of known amounts of Igs added to urine was 92-118%. In the normoalbuminuria group, urinary concentrations of albumin, IgG2, IgA, and IgM were significantly higher than in @entity1 , whereas in the microalbuminuria, further elevation of IgG2, IgG4, and IgA was the most pronounced. In all three groups, fractional excretion of Igs was at least 100 times lower than that of albumin. Fractional excretion of IgG2 was the highest among all Igs. We validated a sensitive method for measuring Igs in urine using Luminex. We found that elevated concentrations of Igs, particularly in IgG2 and IgA, is present in subjects with @entity4 and no @entity3 . Elevation of those particular Ig subtypes suggests a contribution of novel mechanisms in early @entity5 , different from charge and size barrier impairment.

title: Elevated urinary excretion of immunoglobulins in nonproteinuric patients with XXXX .

answer: @entity4


abstract: OBJECTIVE: To extend the molecular analysis of the @entity7 intronic @entity2 (TG) mutation, and to report the eleven year follow-up of the affected @entity0 . METHOSD: Two siblings with severe @entity6 with fetal and @entity4 , harboring the @entity7 mutation were included. Nodular and non-nodular thyroid tissue specimens were collected. Specific thyroid genes expression was evaluated by real-timePCR and by immunohistochemistry. RESULTS: In non-nodular tissue specific thyroid genes mRNA were reduced when compared to normal thyroid sample. In the nodule, @entity5 and NIS expression was very low. Microscopic examinations showed very large follicular-lumina and swollen vesicles of endoplasmatic-reticulum. Strong cytoplasmatic and low follicular-lumen TG immunostaining were detected. Intracellular NIS, membrane @entity5 and @entity3 immunostaining had higher positivity in non-nodular sample. Both @entity0 had a long-term adequate developmental outcome, besides one @entity0 have been lately-treated. CONCLUSIONS: @entity7 mutation not only lead to very enlarge endoplasmatic-reticulum, but also to alterations of specific thyroid genes expression. The clinical evolution of @entity0 harboring these mutations strengthen the concept of the influence of environment, like @entity1 nutrition, to determine the final phenotypic appearance.

title: A molecular analysis and long-term follow-up of two siblings with severe @entity6 carrying the XXXX intronic @entity2 mutation.

answer: @entity7


abstract: UNASSIGNED: The antipsychotics @entity2 , @entity3 and @entity7 are frequently prescribed for the treatment in @entity0 with @entity4 . The aim of this study was to validate an ultra-high performance liquid chromatography-mass spectrometry method for the quantification of these antipsychotics in plasma. An ultra-high performance liquid chromatography-mass spectrometry assay was developed for the determination of the drugs and metabolites. Gradient elution was performed on a reversed-phase column with a mobile phase consisting of @entity6 , @entity5 in @entity1 or in Milli-Q ultrapure water at a flow rate of 0.5   mL/min. The method was validated according to the US Food and Drug Administration guidelines. The analytes were found to be stable enough after reconstitution and injection of only 5    L improved the accuracy and precision in combination with the internal standard. Calibration curves of all five analytes were linear. All analytes were stable for at least 72   h in the autosampler and the high quality control of @entity8 was stable for 48   h. The method allows quantification of all analytes. The advantage of this method is the combination of a minimal injection volume, a short run-time, an easy sample preparation method and the ability to quantify all analytes in one run. Copyright    2015 John Wiley _ Sons, Ltd.

title: Identification and quantification of the antipsychotics @entity2 , XXXX , @entity7 and their major metabolites in plasma using ultra-high performance liquid chromatography-mass spectrometry.

answer: @entity3


abstract: PURPOSE: Low dose rate radioemitters, such as 125I, 103Pd, and 89Sr, have been used both for @entity4 . Most normal cells exposed to ionizing radiation characteristically activate cell cycle checkpoints, resulting in cell cycle arrest at the G1/S and G2/M transition points. @entity1 cells are typically quite sensitive to radiation killing late in the G2 phase of the replicative cell cycle. Furthermore, most @entity1 cells accumulating at the G2/M transition point as a result of low dose rate radiation exposure appear to become sensitive to further low dose rate irradiation. For this reason, protracted exposure of @entity1 cells to low dose rate radiation has been proposed to result in increased @entity1 cell killing as compared with brief exposures of @entity1 cells to high dose rate radiation. Since many @entity0 @entity4 contain somatic genome alterations targeting genes which affect the cell cycle and radiation-associated cell cycle checkpoints, we evaluated the effects of low dose rate radiation exposure on the cell cycle and on clonogenic survival for various @entity0 @entity4 cell lines. MATERIALS AND METHODS: @entity0 @entity4 cells from the LNCaP, DU 145, PC-3, PPC-1, and TSU- @entity2 cell lines were exposed to low dose rate (0.25 Gy/hour) or high dose rate (60 Gy/hour) radiation in vitro and then assessed for radiation @entity3 by clonogenic survival assay. Cell cycle perturbations following protracted exposure to low dose rate radiation were evaluated using flow cytometry. RESULTS: For LNCaP cells, low dose rate radiation exposure resulted in an accumulation of cells at both the G1/S and the G2/M cell cycle transition points. For DU 145, PC-3, PPC-1, and TSU- @entity2 cells, treatment with low dose rate radiation triggered G2/M cell cycle arrest, but not G1/S arrest. Unexpectedly, the cell cycle redistribution pattern phenotypes observed, G1/S and G2/M cell cycle arrest versus G2/M arrest alone, appeared to have little effect on low dose rate radiation survival. Furthermore, while PC-3, PPC-1, and TSU- @entity2 cells exhibited increased cytotoxic sensitivity to low dose rate versus fractionated high dose rate radiation treatment, DU 145 and LNCaP cells did not. CONCLUSIONS: Radiation-associated pertubations in replicative cell cycle progression were not dominant determinants of low dose rate radiation killing efficacy in @entity0 @entity4 cell lines in vitro.

title: Sensitivity of @entity0 XXXX cell lines to low dose rate radiation exposure.

answer: @entity4


abstract: OBJECTIVES: To study the effects of a one-year physical activity programme on aerobic capacity, physical activity and health-related quality of life (HRQL) in @entity0 with @entity3 ( @entity3 ) by a randomized control design. METHODS: Thirty-five @entity0 with @entity2 activity and organ damage were randomized to intervention (I) or control (C) group. The intervention during months 0-3 consisted of education, supervised aerobic exercise at high intensity and individual @entity4 , as well as self-managed physical activity at low-to-moderate intensity. During months 4-12, the physical activity was self-managed and the @entity4 was successively reduced over time. Outcome measures included: maximal @entity1 uptake (VO2 max) from a bicycle ergometer test, self-reported physical activity and HRQL (SF-36). RESULTS: VO2 at sub-max. and max. increased, independent of group, during the one-year study period (main effect of time p   <   0.0001). VO2 max. increased between baseline and month 3 (p   <   0.0001), between months 3 and 6 (p   =   0.01) and the increase was sustained at month 12 (ns). Frequency of physical activity at high intensity also increased, independent of group, during the study period. It was increased at months 3, 6 and 12 compared to baseline (p   =   0.02, p   <   0.001, p   =   0.03). Improvement in mental health between baseline and month 6 (p   =   0.002) was seen for the I-group, not the C-group (p   =   0.03). Disease activity and organ damage did not change. CONCLUSIONS: Physical activity and aerobic capacity increased after supervised exercise and @entity4 , and the improvement was sustained during the one-year programme. However, no interactions between the group differences were seen, which suggests that repeated measurements could motivate to increased physical activity and thereby to increased aerobic capacity. As sub-max. VO2 increased over time, training-induced changes in VO2 on-kinetics could be another explanation. Little influence on HRQL was seen after the programme. The study indicates that physical activity at high intensity over one year is tolerated by @entity0 with mild to moderate @entity3 .

title: Effects of a one-year physical activity programme for XXXX with @entity3 - a randomized controlled study.

answer: @entity0


abstract: BACKGROUND: @entity6 ( @entity6 ) inhibitors reduce urine protein excretion and slow the progression of @entity1 . The beneficial effect in slowing the progression of @entity1 is greater in @entity0 with higher urine protein excretion at the onset of treatment. We hypothesized that the greater beneficial effect of @entity6 inhibitors on the progression of @entity1 in @entity0 with higher baseline levels of @entity4 is due to their greater antiproteinuric effect in these @entity0 . METHODS: Data were analyzed from 1860 @entity0 enrolled in 11 randomized controlled trials comparing the effect of antihypertensive regimens, including @entity6 inhibitors to regimens not including @entity6 inhibitors on the progression of @entity7 . Multivariable linear regression analysis was used to assess the relationship between the level of @entity4 at baseline and changes in urine protein excretion during follow-up. The Cox proportional hazards analysis was used to assess the relationship between changes in urine protein excretion during follow-up and the effect of @entity6 inhibitors on the time to doubling of baseline serum @entity5 values or onset of @entity2 . RESULTS: Mean (median) baseline urine protein excretion was 1.8 (0.94) g/day. @entity0 with higher baseline urine protein excretion values had a greater reduction in @entity4 during the follow-up in association with treatment with @entity6 inhibitors and in association with lowering @entity3 (interaction P < 0.001 for all). A higher level of urine protein excretion during follow-up (baseline minus change) was associated with a greater risk of progression [relative risk 5.56 (3.87 to 7.98) for each 1.0 g/day higher protein excretion]. After controlling for the current level of urine protein excretion, the beneficial effect of @entity6 inhibitors remained significant [relative risk for @entity6 inhibitors vs. control was 0.66 (0.52 to 0.83)], but there was no significant interaction between the beneficial effect of @entity6 inhibitors and the baseline level of urine protein excretion. CONCLUSIONS: The antiproteinuric effects of @entity6 inhibitors and lowering blood pressure are greater in @entity0 with a higher baseline urine protein excretion. The greater beneficial effect of @entity6 inhibitors on @entity1 progression in @entity0 with higher baseline @entity4 can be explained by their greater antiproteinuric effects in these @entity0 . The current level of urine protein excretion is a modifiable risk factor for the progression of @entity7 . @entity6 inhibitors provide greater beneficial effect at all levels of current urine protein excretion.

title: XXXX as a modifiable risk factor for the progression of @entity7 .

answer: @entity4


abstract: BACKGROUND: @entity5 is a rare @entity4 of neuroendocrine origin, which is characterized by a high rate of recurrence, metastatic spread and mortality. Because of its rarity, evidence-based therapeutic regimens are difficult to establish. @entity5 is known to be both radio- and chemosensitive. @entity2 is a key factor in assessing any regimen, as the @entity0 are usually elderly and likely to have other significant medical problems. @entity0 AND METHODS: We retrospectively evaluated five @entity0 with metastatic @entity5 to see if liposomal @entity3 (Caelyx) or Myocet) in combination with radiotherapy exhibited clinical anti-tumoral effects accompanied by acceptable side effects. RESULTS: The outpatient chemotherapy regimen was tolerated without major side effects and produced good response rates. All @entity0 achieved at @entity1 stabilization; four of five had a partial remission. Effects of therapy were usually seen in the first cycle of therapy but the responses were of short duration with an average interval of two months until progression. CONCLUSIONS: As combined radiochemotherapy with liposomal @entity3 is well tolerated even in older @entity0 with other illnesses and can be given on an outpatient basis, it is an attractive option for metastatic @entity5 . Based on response rate or overall survival, it offers no advantages compared to polychemotherapy.

title: Therapy of metastasized @entity5 with liposomal XXXX in combination with radiotherapy.

answer: @entity3


abstract: OBJECTIVES: To describe and analyze the intubating conditions and hemodynamic effects of @entity6 in @entity0 undergoing @entity2 ( @entity2 ) in the emergency department. METHODS: The authors conducted a prospective observational study of all @entity0 who received @entity6 for induction of @entity2 over a 42-month period in a large tertiary care teaching hospital. Intubating conditions were determined by the emergency physician for both sedation and @entity1 and for technical difficulty using a five-point Likert scale. Hemodynamic effects were evaluated before, after, and every five minutes for 15 minutes following administration of @entity6 . RESULTS: @entity6 was used for induction of @entity2 in 522 @entity0 , all of whom were included in the final efficacy analysis, while 491 were included in the analysis of hemodynamics. @entity4 and @entity5 were used as pretreatment in 65.1% and 26.1% of @entity0 , respectively, while @entity3 was the paralytic in 94.3% of intubations. Sedation and @entity1 were rated as excellent or good in 88.1% and 8.8% of @entity0 , respectively, while technical difficulty was very easy or easy in 60.7% and 19.0% of @entity0 , respectively. Mean (+/- SD) baseline systolic blood pressure (sBP), diastolic blood pressure (dBP), and heart rate were found to be 132.7 (+/- 35.4) mm Hg, 69.5 (+/- 21.2) mm Hg, and 96.1 (+/- 26.2) bpm, respectively. Overall, there was a clinically insignificant elevation in sBP (p < 0.0001), @entity7 (p = 0.0002), and heart rate (p < 0.0001) immediately postintubation. Elevations in sBP persisted at five minutes (p = 0.0230) and ten minutes (p = 0.0254) postintubation. Diastolic blood pressure and heart rate returned to baseline at five minutes after intubation and remained stable throughout the 15-minute postintubation assessment period. In the subgroup of 80 @entity0 with a preintubation sBP < 100 mm Hg, there was a 12.1-mm Hg elevation in sBP (p < 0.0001) and a 7.3-mm Hg elevation in dBP (p = 0.0001) immediately postintubation. This elevation persisted throughout the 15-minute postintubation assessment period. CONCLUSIONS: @entity6 appears to provide appropriate intubating conditions in a heterogeneous group of @entity0 undergoing @entity2 in the emergency department. Hemodynamic stability appears to be present following administration of this agent, even in @entity0 with low pre- @entity2 blood pressure. This attribute must be weighed against potential adverse effects of this agent, including adrenal suppression.

title: Intubating conditions and hemodynamic effects of @entity6 for XXXX in the emergency department: an observational cohort study.

answer: @entity2


abstract: @entity1 were fed diets containing 7.5% added @entity6 , @entity8 , or @entity10 for 21 days. In addition, 50 microCi/kg cerium-141 was included for the last 10 days on experimental diets as an unabsorbed reference substance. In the rumen dietary @entity4 were approximately 50% hydrolyzed, and hydrogenation resulted in saturation of the free @entity2 fraction. Some net synthesis of phospholipids, presumably microbial phospholipids, occurred in the rumen. In the intestine immediately distal to the pylorus, extensive secretion of @entity7 , @entity0 , phospholipids, @entity4 , free @entity5 , and lipase occurred. This resulted in doubling of @entity2 fluxes through the duodenum. These endogenous secretions were reabsorbed rapidly however, with the major site of lipid and @entity9 absorption in the region .6 to 4 m distal to the pylorus. Additional but less absorption occurred in the more distal segments of the small intestine. Overall absorption of @entity6 , @entity8 , and @entity10 supplements was in the range 60 to 70%, and no differences were apparent between fats. @entity3 were over 90% absorbed as compared with 55 to 65% for @entity5 . No significant effect of any of the supplements was observed on ruminal total volatile @entity5 , ratios of volatile @entity5 , or on overall cellulose or caloric digestion.

title: Digestion and absorption of lipids and @entity7 in @entity1 fed @entity6 , @entity8 , or XXXX .

answer: @entity10


abstract: BACKGROUND: The common mantra with which @entity0 often leave a burns unit is "moisturize and massage". Various products have been reported for use in practice including aqueous cream BP, @entity6 wax and herbal oil creams, @entity4 based creams, @entity3 /petroleum/mineral oil based products and aloe vera gels. Often combined with other scar management techniques such as pressure therapy, massage and contact media, moisturizers convey active properties of their own.   To date no published review on the optimal moisturizer for burn scar management has been identified via searches of recognized databases. OBJECTIVES: The objective of this review was to identify and synthesize the best available evidence on the effectiveness of moisturizer use in the management of active @entity5 following @entity1 .   More specifically, this review focused on the following questions:   Does moisturizer use have an effect on scar outcomes following @entity1 , including scar formation, skin breakdown, @entity0 acceptance and water loss?   What is the optimal base composition of moisturizers used in scar management for @entity0 who have sustained a @entity1 ? INCLUSION CRITERIA: Types of @entity0 :   @entity0 of any age who have sustained a @entity1 of any size, and have been admitted to a hospital or regional burn unit or burn centre for the management of their @entity1 .   Types of intervention(s)/phenomena of interest:   Studies evaluating moisturizer applied to healed skin following @entity1 were considered for inclusion. Moisturizer may have been compared to usual care as defined by the individual study, other interventions, or a different type of moisturizer. Studies comparing moisturizer and massage compared to moisturizer alone were excluded.   Types of studies:   This review primarily considered experimental study designs, including randomized and pseudo-randomized controlled trials.   Types of outcomes:   Primary outcomes for examination in this review included scar formation and skin breakdown, measured by objective tools or subjective scales.   Secondary outcomes included product acceptance, @entity0 compliance and transepidermal water loss. SEARCH STRATEGY: A search was conducted to identify published and unpublished studies via electronic databases. Reference lists of all papers selected for full text retrieval were then hand searched for potential additional citations. METHODOLOGICAL QUALITY: Articles meeting pre-determined eligibility criteria for the review were assessed by two independent reviewers using standardized checklists from the Joanna Briggs Institute Meta Analysis of Statistics Assessment and Review Instrument. Corresponding authors were contacted where additional information was required; however this strategy did not yield additional information that altered study eligibility status. DATA COLLECTION: Data was extracted from the included paper using the standardized data extraction tool from the Joanna Briggs Institute Meta Analysis of Statistics Assessment and Review Instrument. DATA SYNTHESIS: Narrative synthesis of the included study was undertaken. RESULTS: One study, following a randomized controlled design, was eligible for inclusion in this review. This study investigated the effect of @entity2 cream versus a base moisturizing cream on outcomes including @entity7 , scar thickness, cosmetic appearance and graft size. No significant differences between groups for all reported outcomes were observed. CONCLUSIONS: Despite the common practice involving moisturizers TRUNCATED AT 500 WORDS.

title: The effectiveness of moisturizers in the management of @entity5 following XXXX : a systematic review.

answer: @entity1


abstract: In 1989, we reported on the efficacy of liver transplantation in @entity4 ( @entity4 ) by demonstrating that the actual @entity0 survival following transplantation was significantly better than without transplantation as predicted by a mathematical survival model ("Mayo natural history model"). Our aim in this investigation was to determine an optimal time to perform liver transplantation in @entity4 . One hundred forty-three @entity0 with @entity4 undergoing liver transplantation were followed prospectively. Disease severity was measured immediately before transplantation by a summary score ("risk score") used in the Mayo natural history model, namely age, @entity3 , albumin, prothrombin time, and the presence or absence of @entity1 . Proportional hazards analyses were performed assessing @entity0 survival following transplantation. The influence of disease severity immediately pretransplantation on resource utilization for liver transplantation was assessed. Compared with our report in 1989, liver transplantation was performed at an earlier stage of disease (e.g., median risk score: 7.5 vs. 8.3; P < .01). Following transplantation, @entity0 survival probabilities at 1, 2, and 5 years were 93%, 90%, and 88%, respectively. In the proportional hazards analysis, the risk of @entity2 following transplantation remained low until reaching a risk score of 7.8. In contrast, risk scores greater than 7.8 were associated with a progressively increased mortality. Resource utilization measured by the days in the intensive care unit (ICU) and hospital and the requirement for intraoperative blood transfusions was significantly greater in recipients who had higher risk scores before transplantation. Our data suggest that an optimal timing for liver transplantation, as determined by @entity0 survival and resource utilization, appears to be at a risk score around 7.8 in @entity0 with @entity4 .

title: Optimal timing of liver transplantation for XXXX .

answer: @entity4


abstract: The management of hip instability as a consequence of @entity3 in childhood is difficult. Ilizarov hip reconstruction is a double-level femoral osteotomy with the objective of eliminating hip instability, through a proximal valgus-extension-derotation osteotomy and a distal varization-lengthening osteotomy for mechanical axis correction and equalization limb length. Ilizarov hip reconstruction was performed for 16 adult @entity0 with complaints of @entity1 , @entity2 , limping, reduced activity and limited abduction of the hip as a result of @entity3 . Their ages ranged from 19 to 32  years (mean 23.2      4.2). Ilizarov external fixator was used in all cases. At the time of last follow-up that ranged from 60 to 132  months (mean 85.6      23.5), the Harris hip score (HHS) showed excellent functional outcome in two cases (12.50  %), good in 13 cases (81.25  %) and fair in one case (6.25  %). There was no poor functional outcome in any case. Preoperatively, the mean HHS was 56.18 points, and at the time of last follow-up, it improved to a mean of 84.62 points. @entity1 subsided in all @entity0 , the Trendelenburg sign became negative in all but three (19  %) @entity0 , no @entity0 had limb-length discrepancy, and the alignment of the extremity was reestablished in all cases. No additional operations were required. Ilizarov hip reconstruction is a valuable and durable solution for the late sequelae of @entity3 of the hip presenting in adult @entity0 .

title: Midterm results of Ilizarov hip reconstruction for late sequelae of XXXX .

answer: @entity3


abstract: Allogeneic BMT is potentially curative for @entity0 with @entity2 ( @entity2 ) in first remission. However, many @entity0 relapse after transplantation. Various immunotherapeutic options have been attempted with variable success in preventing relapse. Early identification of @entity0 at high risk for relapse could allow prompt intervention. We examined the effect of slow lymphocyte recovery after sibling-matched allogeneic BMT on the risk of relapse in @entity0 with @entity2 . We also examined the effect of @entity1 -containing GVHD prophylaxis on the rate of lymphocyte recovery. @entity0 with @entity3 ( @entity3 ) <150 x 10(6)/l by day +30 had a 3.5-fold higher risk of relapse (P = 0.0088) and a lower overall survival (P = 0.0079) than @entity0 with a higher @entity3 . We did not find correlation between lymphocyte count determined earlier in the post-transplantation course (day +21) and the risk of relapse. @entity0 receiving @entity1 had a significantly lower @entity3 at day +30 than those who did not receive @entity1 (289 vs 549 x 10(6)/l, P = 0.002). We conclude that a slow lymphocyte recovery after allogeneic BMT for @entity2 is strongly predictive of subsequent relapse and that the type of GVHD prophylaxis should be considered when analyzing lymphocyte recovery.

title: Effect of slow lymphocyte recovery and type of graft-versus-host disease prophylaxis on relapse after allogeneic bone marrow transplantation for XXXX .

answer: @entity2


abstract: INTRODUCTION: Informed decision making has been highlighted as an important aspect of @entity1 screening programs. This study seeks to assess the efficacy of a web-based @entity0 decision @entity2 for @entity1 screening, www.shouldiscreen.com. METHODS: A before-and-after study (August through December 2014) was conducted where @entity0 navigated a web-based decision @entity2 that provided information about low-dose computed tomography @entity1 screening. Using an established prediction model, the decision @entity2 computed baseline @entity1 risk and an individual's chances of benefiting from, and risk of being harmed by, screening. Outcome measures included knowledge of @entity1 risk factors and @entity1 screening, decisional conflict, concordance, and acceptability of the decision @entity2 . Data were collected from 60 @entity0 who were current or former smokers, had no history of @entity1 , and had not received a chest computed tomographic scan in the previous year. Analysis took place in 2015. RESULTS: Knowledge increased after seeing the decision @entity2 compared with before (p<0.001), whereas the score on the Decisional Conflict Scale decreased (p<0.001). Concordance between a @entity0 's preference to screen and the U.S. Preventive Services Task Force recommendation improved after seeing the decision @entity2 (p<0.001). Risk perceptions among the screen-ineligible group changed (n=49), contrary to those who were eligible (n=11). Ninety-seven percent of the @entity0 reported that the decision @entity2 was likely useful for @entity1 screening decision making. CONCLUSIONS: The web-based decision @entity2 should be a helpful resource for individuals considering @entity1 screening, as well as for practitioners and health systems with @entity1 screening programs.

title: Evaluation of a Personalized, Web-Based Decision XXXX for Lung Cancer Screening.

answer: @entity2


abstract: @entity2 exposed to @entity0 during a critical period from gestational day (GD) 30 to GD 90 develop masculine genitals and an enlarged male-typical ovine sexually dimorphic nucleus of the preoptic area (oSDN). The present study tested the hypothesis that separate critical periods exist for masculinization of these two anatomical end points. Pregnant ewes were treated with @entity3 (TP) either from GD 30 to GD 60 (early TP) or GD 60 to GD 90 (late TP). Control (C) pregnant ewes were treated with @entity4 oil. Fetuses were delivered at GD 135 and the volume of the oSDN was measured. Early TP females possessed a penis and a scrotum devoid of testes, whereas late TP and C females had normal female genitals. Neither period of TP exposure grossly affected the genitals of male fetuses. Despite masculinized genitals, the mean volume of the oSDN in early TP females (0.32    0.06 mm  ) was not different from C females (0.24    0.02 mm  ) but was significantly enlarged in late TP females (0.49    0.04 mm  ; P < 0.05 vs. C) when the genitals appeared normal. In contrast, the volume of the oSDN in late TP males (0.51    0.02 mm  ) was not different from C males (0.51    0.04 mm  ) but was significantly smaller in the early TP males (0.35    0.04 mm  ; P < 0.05 vs. C). These results demonstrate that the prenatal critical period for @entity1 -dependent differentiation of the oSDN occurs later than, and can be separated temporally from, the period for development of masculine genitals.

title: Separate critical periods exist for XXXX -induced differentiation of the brain and genitals in @entity2 .

answer: @entity0


abstract: UNASSIGNED: e15589 Background: @entity7 is an oral drug with alkylating activity and low @entity2 profile including no @entity6 and scarce @entity5 . Its activity in recurrent @entity1 is well known but new drugs with more activity have reduced its use. METHODS: We present a retrospective study with @entity7 in @entity0 with recurrent @entity1 failing to the standard second line treatments or as maintenance after achieving a response to second line therapy. The dose used was 400 mg daily, during fourteen days every four weeks, until @entity2 or disease progression.Our objective was to evaluate the activity and @entity2 profile of @entity7 in the second line setting of @entity1 @entity0 . RESULTS: Median age was 53years old. Eight @entity0 were treated with @entity7 as maintenance after achieving a complete or a partial response with a standard second line regimen to prolong the PFS. 76.5% of the @entity0 have received 3 or more previous lines of chemotherapy. Excluding the eight @entity0 treated for maintenance, 33% achieved complete or partial response, 25% stable disease and 42% progression. The more frequent @entity2 were: nausea in 40% of @entity0 , other @entity3 in 40% and @entity4 in 30%. The median PFS for all the group was 12,1 months and for the maintenance group of @entity0 18,1 months. The maintenance group has received between 4+ and 61+ cycles. CONCLUSIONS: @entity7 is an oral drug with manageable @entity2 and with activity in @entity0 with recurrent @entity1 being another option to be considered after the standard second lines. Also can be used as a maintenance drug for @entity0 in response to prolong the PFS.

title: XXXX for recurrent @entity1 or as maintenance after response to second-line therapy.

answer: @entity7


abstract: Several influences modulate biochemical responses to a weight-adjusted @entity5 ( @entity6 ) replacement dose. We conducted a secondary analysis of the relationship of @entity6 dose to TSH and free T3 (FT3), using a prospective observational study examining the interacting equilibria between thyroid parameters. We studied 353 @entity0 on steady-state @entity6 replacement for @entity4 or after surgery for malignant or benign @entity3 . Peripheral deiodinase activity was calculated as a measure of T4-T3 conversion efficiency. In euthyroid subjects, the median @entity6 dose was 1.3 g/kg per day (interquartile range (IQR) 0.94,1.60). The dose was independently associated with gender, age, aetiology and deiodinase activity (all P<0.001). Comparable FT3 levels required higher @entity6 doses in the @entity1 group (n=143), even after adjusting for different TSH levels. Euthyroid @entity2 @entity0 (n=50) received 1.57 g/kg per day @entity6 (IQR 1.40, 1.69), compared to 1.19 g/kg per day (0.85,1.47) in @entity4 (P<0.01, n=76) and 1.08 g/kg per day (0.82, 1.44) in @entity0 operated on for benign disease (P< 0.01, n=80). Stratifying @entity0 by deiodinase activity categories of <23, 23-29 and >29nmol/s revealed an increasing FT3-FT4 dissociation; the poorest converters showed the lowest FT3 levels in spite of the highest dose and circulating FT4 (P<0.001). An @entity6 -related FT3-TSH disjoint was also apparent; some @entity0 with fully suppressed TSH failed to raise FT3 above the median level. These findings imply that @entity7 conversion efficiency is an important modulator of the biochemical response to @entity6 ; FT3 measurement may be an additional treatment target; and @entity6 dose escalation may have limited success to raise FT3 appropriately in some cases.

title: Variation in the biochemical response to @entity5 therapy and relationship with peripheral XXXX conversion efficiency.

answer: @entity7


abstract: BACKGROUND: To evaluate efficacy and @entity2 of radio-chemotherapy (RCT) and MR-guided pulsed-dose-rate (PDR) adaptive brachytherapy (IGABT) for locally advanced @entity1 (LACC). MATERIAL AND METHODS: Between 2007 and 2014 85 @entity0 with FIGO stage 1B1 N+ or >=  1B2 @entity1 were treated with RCT+ IGABT. The treatment consisted of a pelvic   paraaortic external beam radiotherapy (EBRT) (45-50.4 Gy    10 Gy boost to @entity1 and/or to pathologic lymph nodes) with concurrent @entity5 followed by 25-35 Gy of PDR IGABT in 30-50 pulses. The ratio of 3D-CFRT/IMRT was 61/24 @entity0 . Dose-volume parameters of high-risk clinical target volume (HR-CTV), intermediate-risk clinical target volume (IR-CTV) and D2cm(3) organs at risk (OARs) were reported. Local control (LC), @entity1 -specific survival (CCS) and @entity6 ( @entity6 ) were analyzed actuarially and morbidity crude rates were scored using CTCAEv4.0. RESULTS: Mean follow-up was 36 months (range 6-94). The mean D90 and D98 for HR-CTV was 84.4    9 Gy and 77    8.1 Gy, while for IR-CTV was 69.1    4.3 Gy and 64.8    4.3 Gy, respectively. The mean D2cm(3) for OARs was the following: bladder: 77.3    10.5 Gy, rectum: 65    6.8 Gy, sigmoid: 63    7.9 Gy and intestine: 64.0    9.1 Gy. Three year LC, CSS and @entity6 were: 94%, 85% and 81%. The three-year regional- and distant control rates were 95% and 74%. Node negative @entity0 had significantly higher three-year CSS (100 vs. 72%, p = 0.016) and @entity6 (92 vs. 72%, p = 0.001) compared to node positive ones. Three-year actuarial late Grade >=  3 morbidity was the following: GI: 8%, GU: 5%, Vaginal: 8%. The frequency of Grade >=  3 hematological @entity2 including @entity3 / @entity8 / @entity7 / @entity4 were 8.6%/34.7%/24.3%/24.3%, respectively. CONCLUSION: This large mono-institutional experience builds up further evidences that IGABT in conjunction with RCT should be the standard of care for @entity0 suffering LACC.

title: Clinical efficacy and @entity2 of radio-chemotherapy and magnetic resonance imaging-guided brachytherapy for locally advanced XXXX @entity0 : A mono-institutional experience.

answer: @entity1


abstract: OBJECTIVE: The goal of this study was to report the delivery outcomes in @entity0 who had loop electrosurgical excision procedure (LEEP) for @entity1 (stage @entity6 without lymphovascular invasion) and became pregnant and progressed beyond 24 weeks. METHODS: A case-control study was performed. Twenty-eight @entity0 who were managed exclusively with LEEP for @entity4 had at least one pregnancy beyond 24 weeks and were the cases. Each case was matched with one @entity0 who delivered at the same department without prior treatment of her cervix (controls) and their delivery outcomes were compared with those of the cases. Known risk factors for @entity5 were used as matching factors. RESULTS: There was no statistically significant difference (P > 0.05) between cases and controls in the duration of pregnancy (37.6-38.4 weeks respectively), birth weight (3212-3315 g), cesarean section rate (17.8-32.1%), neonatal unit admission rate (21.4-10.7%), and precipitate labor rate (13-10.5%). The duration of labor was significantly shorter in cases (5.5-7.1 h, P = 0.032). After LEEP the relative risk for @entity5 is 3.67 (95% confidence interval, 0.97-20.27), for low birth weight @entity0 0.67 (0.06-5.8), for precipitate labor 1 (0.05-3.88), and for delivery by cesarean section 0.5 (0.17-4.46). CONCLUSIONS: @entity0 treated for @entity1 with LEEP did not have significantly more @entity3 compared with controls apart from shorter duration of labor. There was a possible non-statistically significant trend toward shorter duration of pregnancy in cases. While caution should be advised when selecting and treating @entity0 with @entity2 by LEEP, the apparent safety of the management and the satisfactory delivery outcome seem to justify this approach in many cases.

title: Delivery outcomes following loop electrosurgical excision procedure for microinvasive (FIGO stage @entity6 ) cervical XXXX .

answer: @entity1


abstract: BACKGROUND: The pathogenesis of @entity1 ( @entity1 ) in @entity0 with severe @entity2 is still unclear. It has been hypothesized that @entity5 depends, in addition to microvascular obstruction, on an increased pulmonary capillary pressure and altered alveolar-capillary membrane permeability, causing pulmonary fluid accumulation. METHODS: This study compared the histopathological features of @entity5 in Southeast Asian @entity0 (n  =  43) who died from severe @entity7 @entity2 , and correlated these with clinical history in groups with or without @entity1 . To investigate the expression of mediators that may influence fluid accumulation in @entity1 , immunohistochemistry and image analysis were performed on controls and sub-sets of @entity0 with or without @entity1 . RESULTS: The expression of leukocyte sub-set antigens, bronchial interleukin (IL)-33, y-epithelium @entity6 channel (ENaC), aquaporin ( @entity9 , and control cytokeratin staining was quantified in the lung tissue of severe @entity2 @entity0 . Bronchial @entity8 expression was significantly increased in severe @entity2 @entity0 with @entity1 . @entity2 @entity0 with shock showed significantly increased bronchial @entity8 compare to other clinical manifestations. Bronchial @entity8 levels were positively correlated with @entity4 + monocyte and elastase  +  neutrophil, septal congestion and hyaline membrane formation. Moreover, the expression of both vascular smooth muscle cell (VSMC) and bronchial y-ENaC significantly decreased in severe @entity2 @entity0 with @entity1 . Both VSMC and bronchial y-ENaC were negatively correlated with the degree of parasitized erythrocyte sequestration, alveolar thickness, alveolar expansion score, septal congestion score, and malarial pigment score. In contrast @entity9 and pan cytokeratin levels were similar between groups. CONCLUSIONS: The results suggest that @entity8 may play a role in @entity5 during severe @entity2 and lead to @entity1 . Both VSMC and bronchial y-ENaC downregulation may explain @entity3 and participate in @entity1 pathogenesis in severe @entity2 @entity0 .

title: A potential role for @entity8 and y-epithelium @entity6 channel in the pathogenesis of @entity0 XXXX associated @entity5 .

answer: @entity2


abstract: The aim of this study was to determine the correlation between changes in collagen metabolites (ICTP, mature cross-linked @entity5 -terminal telopeptide of type I collagen; PINP, the @entity4 -terminal propeptide of @entity7 ) and @entity2 ( @entity2 ) in 206 pre- and post-menopausal @entity0 @entity1 with non-metastatic disease. All @entity1 received adjuvant cancer treatment--premenopausal @entity1 chemotherapy and post-menopausal patients anti- @entity6 . In addition, the @entity1 were also randomized to receive oral @entity9 1600 mg daily for 3 years. @entity2 was measured at baseline and at 1 and 2 years, the collagen metabolites at baseline and at 1 year. There was a highly significant negative correlation between the changes in PINP and @entity2 in lumbar spine and femoral neck from baseline to 12 months in all @entity1 (r(s) = -0.68, P < 0.0001, and -0.45, P < 0.0001, respectively), and in pre- and post-menopausal @entity1 separately. The changes in PINP levels at 12 months predict further changes in @entity2 at 24 months (r = -0.70, P < 0.0001, and -0.51, P < 0.0001, respectively). ICTP and @entity2 changes correlated significantly only in lumbar spine of premenopausal @entity1 who developed rapid @entity3 due to chemotherapy-induced @entity8 (r(s) = -0.34, P = 0.0003). The PINP levels at 12 months were significantly lower in the @entity9 group than in the control group (P < 0.0001). Our results indicate that PINP is a sensitive marker of bone turnover rate. Changes in PINP levels significantly predicted changes in @entity2 and correlated with the antiresorptive efficacy of @entity9 treatment.

title: Aminoterminal propeptide of @entity7 (PINP) correlates to @entity3 and predicts the efficacy of antiresorptive therapy in pre- and post-menopausal non-metastatic XXXX @entity1 .

answer: @entity0