abstract: BACKGROUND: This is a case of a solitary @entity2 in a 65-year-old male. The @entity0 was diagnosed with @entity5 in 1991. He had negative radiologic and surgical explorations at that time. He was maintained on proton-pump inhibitors for the next 10 years without symptoms. METHODS: A computed tomographic (CT) scan done in April 2001 demonstrated a 5-cm right hepatic lesion. Radionucleotide scanning with @entity3 demonstrated intense activity in the same area in the right hepatic lobe. His serum @entity4 was 317 pg/mL. He underwent laparoscopic radiofrequency ablation of the lesion. RESULTS: Treatment resulted in a 6-cm ablative area giving a 1-cm margin on the @entity1 . One- and 3-month follow-up CT scans demonstrated adequate ablation of the @entity1 . An octreotide scan done 3 months postoperatively did not reveal any areas of abnormal uptake. CONCLUSION: We report success with laparoscopic radiofrequency ablation as an alternative to major hepatic resection in @entity0 with a solitary @entity2 .

title: XXXX treated with laparoscopic radiofrequency ablation.

answer: @entity2


abstract: UNASSIGNED: @entity3 proteins (HSPs) are over-expressed in a wide range of @entity1 @entity2 . It results in the stimulation of the immune system and consequently in elevated concentration of anti-HSP autoantibodies. Elevated anti-HSP autoantibodies were found in @entity0 @entity1 , and they are associated with @entity2 metastasis. Therefore, screening these autoantibodies could be of diagnostic and prognostic values. Protein microarrays have already demonstrated their great potential as a diagnostic tool. However, protein diversity requires optimization of the microarray fabrication to achieve high sensitivity and specificity. In this study, seven HSPs were immobilized on six different surface chemistries. After evaluation and optimization with purified antibodies of the six surface chemistries, two surfaces were selected to detect anti-HSP autoantibodies in @entity0 sera. Multiplex detection of anti-HSP autoantibodies allowed discrimination of @entity0 @entity1 (50) from healthy controls (26) with a sensitivity of 86  % and a specificity of 100  %. Graphical abstract Receiver operating characteristic (ROC) curve analysis for the discrimination between @entity0 @entity1 and healthy controls: detection of individual autoantibody on optimal surface chemistry ( @entity4 or chitosan surface) and combination (black line) of the detection of 7 autoantibodies.

title: Anti- XXXX protein autoantibody profiling in @entity0 using customized protein microarray.

answer: @entity3


abstract: OBJECTIVE: @entity4 , @entity3 , and glycemic variability have been associated with increased morbidity, mortality, and overall costs of care in hospitalized @entity0 . At the Stratton VA Medical Center, in Albany, NY, a process aimed to improve inpatient glycemic control by remotely assisting primary care teams in the management of @entity4 and @entity1 was designed. METHODS: An electronic query comprised of hospitalized @entity0 with @entity2 values below 70mg/dL or above 350mg/dL is generated daily. Electronic medical records are individually reviewed by @entity1 specialist providers and management recommendations are sent to primary care teams when applicable. @entity2 data was retrospectively examined before and after the establishment of the DINGS process and rates of @entity4 and @entity3 were compared. RESULTS: @entity0 -day mean @entity2 slightly decreased from 177.6    64.4 mg/dL to 173.2    59.4 mg/dL, P < 0.001. The percentage of @entity0 -days with any value over 350 mg/dL also decreased from 9.69% to 7.36% (P < 0.001), while the percentage of @entity0 -days with mean @entity2 values in the range of 90 to 180 mg/dL increased from 58.1% to 61.4% (P < 0.001). Glycemic variability, assessed by the standard deviation of @entity2 , significantly decreased from 53.9 mg/dL to 49.8 mg/dL (P < 0.001). Moreover, rates of @entity3 (< 70 mg/dL) decreased significantly by 41% (P < 0.001). CONCLUSION: Quality metrics of inpatient glycemic control improved significantly after the establishment of the DINGS process within our facility. Prospective controlled studies are needed to confirm a causal association.

title: DAILY INPATIENT GLYCEMIC SURVEY (DINGS). A PROCESS TO REMOTELY IDENTIFY AND ASSIST IN THE MANAGEMENT OF HOSPITALIZED XXXX WITH DIABETES AND HYPERGLYCEMIA.

answer: @entity0


abstract: PURPOSE: In this proof-of-concept pilot study, our purpose was to determine correlations between gut microbiota composition and alterations in @entity4 and psychosocial outcomes among post-primary treatment @entity0 survivors (BCS). METHODS: Composition of the gut microbiota in BCS (n  =  12) was assessed at baseline (M0) and at the end of 3  months (M3) using Illumina MiSeq DNA Sequencing of the 16S rRNA gene. Gut microbiota composition was analyzed using the QIIME bioinformatics software and represented through diversity metrics and taxa analyses. @entity4 , @entity5 , @entity2 , @entity3 were assessed at M0 and M3 via the submaximal treadmill test, Fatigue Symptom Inventory, Hospital Anxiety and @entity3 Scale, and Pittsburgh Sleep Quality Index, respectively. RESULTS: Increased @entity5 interference in BCS was associated with increased mean within-sample Shannon diversity (organism richness and evenness) (p  =  0.009). Weighted UniFrac analysis (shifts in taxa relative abundance) revealed significant differences in between-sample (beta) diversity for changes in @entity5 interference (p  =  0.01) and @entity2 (p  =  0.022), with a trend observed for @entity5 @entity1 (p  <  0.1). Unweighted UniFrac analysis (shifts in taxa types) found significant beta diversity differences for @entity4 (p  =  0.026). Prior to false discovery correction (FDR), changes in fitness, @entity5 , @entity2 were associated with the frequency of certain gut bacteria genera (e.g., Faecalibacterium, Prevotella, Bacteroides) (p  <  0.05). CONCLUSIONS: Correlations may exist between alterations in gut microbiota composition and longitudinal changes in @entity4 , @entity5 , and @entity2 in BCS. Further research examining the role of the microbiota-gut-brain axis in exercise-induced effects on psychosocial outcomes in BCS is warranted.

title: Gut microbiota composition associated with alterations in @entity4 and psychosocial outcomes among XXXX survivors.

answer: @entity0


abstract: There is scant knowledge on the changes in renal histological findings in type 1 @entity1 @entity0 those initially had @entity11 and @entity6 and later had complete remission of @entity12 by @entity3 ( @entity3 ). A 44-year-old Japanese type 1 @entity1 @entity0 (duration of @entity1 : 17 years) with massive @entity8 (2.9 g/day) and @entity6 ( @entity9 clearance rate (Ccr): 86 mL/min) was admitted. @entity5 @entity3 was started with intensive insulin treatment, a low protein and low salt diet, @entity10 inhibitor and a diuretic. Her levels of HbA1c decreased to less than 7% within 4 months, and her high blood pressure gradually decreased and remained around mean 116/68 mmHg. Her Ccr level gradually improved and reached 108 mL/min after 78 months. Her first renal biopsy performed before @entity3 demonstrated diffuse and/or global accumulation of periodic acid-Schiff staining-positive mesangial matrix with @entity13 /glomerulus ratio and tubulo-interstitial @entity4 . Her second renal biopsy performed 5 years after @entity3 demonstrated decreased mesangial matrix/glomerulus ratio (42.0+/-4.0% to 29.2+/-1.9% [mean+/-S.D.], p<0.001) and increased her number of glomerular capillaries lumen per glomerulus (47+/-11 to 77+/-12, p<0.006). The number of @entity2 ( @entity2 )-expressing cells in the glomerular capillary significantly increased. Increased tubulo-interstitial @entity4 and the thickness of @entity7 ( @entity7 ) seen in the first biopsy specimen had decreased in the specimen taken at the second biopsy. Our case provides evidence that glomerular morphological improvements including decreased mesangial deposit and @entity2 -related vasculogenesis in response to @entity3 goes along with functional normalization of @entity12 , which could not be attained in type 1 @entity1 @entity0 that underwent pancreas transplantation.

title: Complete remission of @entity12 in a type 1 @entity1 XXXX with near- @entity11 range @entity8 and @entity6 .

answer: @entity0


abstract: BACKGROUND: The selection of beef @entity3 for feed efficiency (FE) traits is very important not only for productive and economic efficiency but also for reduced environmental impact of livestock. Considering that FE is multifactorial and expensive to measure, the aim of this study was to identify biological functions and regulatory genes associated with this phenotype. RESULTS: Eight genes were differentially expressed between high and low feed efficient animals (HFE and LFE, respectively). Co-expression analyses identified 34 gene modules of which 4 were strongly associated with FE traits. They were mainly enriched for inflammatory response or @entity0 -related terms. We also identified 463 differentially co-expressed genes which were functionally enriched for immune response and lipid metabolism. A total of 8 key regulators of gene expression profiles affecting FE were found. The LFE animals had higher feed intake and increased subcutaneous and visceral fat deposition. In addition, LFE animals showed higher levels of serum @entity2 and @entity1 biomarker GGT. Histopathology of the liver showed higher percentage of @entity0 with mononuclear infiltrate. CONCLUSION: Liver transcriptomic network analysis coupled with other results demonstrated that LFE animals present altered lipid metabolism and increased @entity1 associated with an inflammatory response composed mainly by mononuclear cells. We are now focusing to identify the causes of @entity4 in LFE animals.

title: Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef XXXX .

answer: @entity3


abstract: @entity8 ( @entity7 ) is one of the main components of traditional Chinese medicine plant Erigeron breviscapus (Vant.) Hand.-Mazz. In this paper, we studied the protective effects of @entity7 on @entity0 cardiac microvascular endothelial cells (HCMECs) against @entity3 and its possible target-related proteins. Results of @entity2 assay showed that pretreatment of @entity7 at doses of 1, 5, and 10    M for 2   h could significantly inhibit the decrease in cell viability of HCMECs induced by @entity3 . Subcellular fractions of cells treated with vehicle control, 1    M @entity7 , @entity3 , or 1    M @entity7 + @entity3 were separated by ultracentrifugation. The protein expression profiles of cytoplasm and membrane/nuclei fractions were checked using protein two-dimensional electrophoresis (2-DE). Proteins differentially expressed between control and @entity7 -treated group, control and HR group, or HR and @entity7 + HR group were identified using mass spectrometry ( @entity1 / @entity1 ). Possible interaction network of these target-related proteins was predicted using bioinformatic analysis. The influence of @entity7 on the expression levels of these proteins was confirmed using Western blotting assay. The results indicated that proteins such as @entity6 protein ( @entity6 ), @entity4 60   kDa protein 1 ( @entity5 ), and @entity9 ( @entity9 ) might play important roles in the effects of @entity7 .

title: Protective Effects of XXXX on @entity0 Cardiac Microvascular Endothelial Cells against @entity3 -Reoxygenation Injury and Its Possible Target-Related Proteins.

answer: @entity8


abstract: AIM: This double-blind, placebo-controlled clinical study compared multiple applications of the Antimicrobial Photodynamic Therapy (aPDT) treatment protocol, to systemic @entity8 as adjuvant to scaling and root planning (SRP) on type 2 @entity1 @entity0 on clinical, systemic and immune-inflammatory outcomes. MATERIALS AND METHODS: Thirty @entity0 with Hba1c >7% were allocated in two groups, SRP+Doxy (n=15) using systemic @entity8 100 mg/day (14 days) and SRP+aPDT (n=15) with multiple applications (0, 3, 7 and 14 days). Primary outcome was glycated haemoglobin levels (HbA1c). Clinical parameters: plaque score (PS), @entity4 on probe, probing depth, suppuration, @entity6 , and clinical attachment level, percentage of pockets with desired clinical endpoint were measured at baseline and 3 months after therapy. Cytokine profile was assessed at 0, 1 and 3 month to measure @entity5 , @entity3 and @entity7 on gingival crevicular fluid. RESULTS: No significant difference was detected on HbA1c, between treatments. The SRP+aPDT group showed advantage on reducing moderate pockets in single-rooted teeth at 3 months. SRP+aPDT presented better results at 3 months on @entity5 levels. There were no significant differences between @entity3 and @entity7 . CONCLUSIONS: Both treatments improved clinical and systemic outcomes (Hba1c). SRP+aPDT performed better in Moderate PPD on single-rooted teeth, reduced favourably @entity2 in short term, and may be an alternative to systemic antibiotics. (Clinicaltrials. org ID NCT01595594). This article is protected by copyright. All rights reserved.

title: Antimicrobial Photodynamic Therapy as an alternative to Systemic Antibiotics: Results from a Double-Blind, Randomized, Placebo-Controlled, Clinical Study on type 2 XXXX .

answer: @entity1


abstract: Stable mixed donor/host hematopoietic chimerism can be accomplished in dog leukocyte antigen (DLA)-identical littermate @entity1 given sublethal (200 cGy) @entity2 ( @entity2 ) before and immunosuppression with @entity3 ( @entity4 ) and @entity0 (CSP) after transplant (Blood 89:3048, 1997). Studies were based on the hypothesis that drugs that prevent @entity5 ( @entity5 ) after transplant also suppress host-versus-graft (HVG) reactions and thereby enhance engraftment. Here, we asked whether pretransplant @entity2 provided marrow space for the graft to home or caused host immunosuppression. To address the questions, recipients were given pretransplant irradiation to cervical, thoracic, and abdominal lymph nodes (except pelvis), DLA-identical littermate marrow grafts, and @entity4 /CSP posttransplant. Six @entity1 that received 450 cGy irradiation showed initial engraftment. Two rejected their grafts after 8 and 18 weeks, 1 died with @entity5 and engraftment, and 3 are alive as mixed chimeras after 57 to 97 weeks. Four @entity1 given 200 cGy irradiation also showed initial engraftment, but rejected their grafts after 10 to 18 weeks. Mixed chimerism was present in nonirradiated marrow and lymph node spaces and involved granulocytes, T cells, and monocytes. While other explanations are possible, results seem consistent with the hypothesis that pretransplant radiation provides host immunosuppression, and grafts can create their own marrow space. These data set the stage for the development of novel transplant regimens that substitute immunosuppressive for cytotoxic agents.

title: Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate XXXX given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantation.

answer: @entity1


abstract: OBJECTIVE: Only a few studies have evaluated the long-term effects of @entity7 ( @entity7 ) on @entity1 ( @entity1 ), and none have examined whether @entity7 improvement reduces @entity1 incidence. We investigated the association between @entity7 improvement and @entity1 incidence. RESEARCH DESIGN AND METHODS: Between 2000 and 2012, 4,604 @entity0 who underwent a health check twice with >10 years between were enrolled. Exclusion criteria were positive hepatitis B surface antigen, positive @entity9 antibody, @entity5 intake >20 g/day, and @entity1 . The 3,074 eligible @entity0 were divided into an @entity7 group (n = 728) and a non- @entity7 group (n = 2,346) according to ultrasonography-detected @entity6 . The @entity7 group was categorized into an improved group (n = 110) and a sustained @entity7 group (n = 618) based on fatty @entity3 at the second visit. Incident @entity1 odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting @entity4 , family history of @entity1 , @entity8 , @entity2 , and physical exercise. RESULTS: @entity1 occurred in 117 @entity0 (16.1%) in the @entity7 group and 72 (3.1%) in the non- @entity7 group. @entity7 at baseline was associated with @entity1 incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). @entity1 occurred in 7 @entity0 (6.4%) in the improved group and in 110 (17.8%) in the sustained @entity7 group. @entity7 improvement was associated with reduced @entity1 incidence (multivariate OR 0.27 [95% CI 0.12-0.61]). CONCLUSIONS: @entity7 improvement is associated with @entity1 incidence reduction.

title: Independent Association Between Improvement of Nonalcoholic Fatty XXXX and Reduced Incidence of @entity1 .

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) of the kidney is a recently described morphological variant of @entity4 . It poses a diagnostic dilemma for clinicians because of its rarity and the overlapping features it shares with other @entity3 . The aim of this paper is to review all the cases of @entity2 in the literature. METHODS: The literature was extensively searched for case reports of @entity2 and the clinical and pathological characteristics of the @entity1 were extracted. RESULTS: A total of 45 cases were reviewed. The mean age of presentation was 50 years (range, 15-83 years) and male sex accounted for 68.8% of the cases reviewed. @entity2 was mostly unilateral with only 4 cases of bilateral involvement of the kidney. The average size of the @entity1 is 1.5 cm (range, 0.1-7 cm). Incidental finding of @entity2 accounted for 62% of the cases reviewed. The ultrasound findings demonstrated varying echogenicity and the @entity1 appeared as solid and well demarcated heterogeneous masses on CT. The average follow up of the @entity0 in this review was 26 months (range, 1-156 months). CONCLUSIONS: @entity2 is a rare @entity1 and a morphological variant of @entity4 . It has a characteristic sinusoidal architecture with a semblance of splenic sinusoids. It has overlapping clinical and imaging features with other @entity1 of the kidney. Histological review and immunohistochemical studies are essential for accurate diagnosis. @entity4 runs a benign course without evidence of disease recurrence during follow up.

title: XXXX of the kidney: a literature review of a rare morphological variant of @entity4 .

answer: @entity4


abstract: AIMS: To investigate whether adjuvant antiviral treatment could improve prognosis and @entity5 is the optimal nucleot(s)ide analogues (NA) regimen after curative therapy of @entity1 -related @entity2 . METHODS: A comprehensive electronic search was performed. All controlled trials comparing antiviral treatment with placebo or no treatment for @entity1 -related @entity2 after curative treatment were included. The pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated using Stata 12.0 software. Indirect treatment comparison method was used to compare the relative efficacy of different NA strategies. RESULTS: Twenty-one studies containing 8072 @entity0 were included. NA was found to significantly improve @entity3 ( @entity3 ) (HR 0.57, 95% CI 0.43-0.74 in RCTs; HR 0.63, 95% CI 0.54-0.74 in cohort studies) and @entity3 ( @entity3 ) (HR 0.41, 95% CI 0.22-0.78 in RCTs; HR 0.62, 95% CI 0.50-0.76 in cohort studies). Alternatively, for interferon, a non-significant benefit was found (HR 0.87, 95% CI 0.70-1.09 for @entity3 and HR 0.65, 95% CI 0.37-1.15 for @entity3 in RCTs). By adjusted indirect comparisons among @entity5 , @entity4 and @entity6 , @entity5 were found to display almost but not significant superiority to the other NA in improving @entity3 ( @entity4 versus @entity5 , HR 2.38, 95%CI 0.91-6.19, P 0.69; @entity6 versus @entity5 , HR 2.67, 95%CI 0.99-7.14, P 0.46). No tendency favouring a specific NA regimen was found for @entity3 . CONCLUSIONS: In @entity1 - @entity2 @entity0 after curative treatment, NA improve the prognosis significantly but the role of interferon remains to be elucidated; @entity5 was not found to be superior to other NA based on available data. This article is protected by copyright. All rights reserved.

title: Adjuvant antiviral therapy for @entity1 -related XXXX after curative treatment: A systematic review and meta-analysis.

answer: @entity2


abstract: PURPOSE: To establish an experimental model for @entity6 mustard-induced acute and delayed @entity11 in @entity3 . METHODS: @entity3 eyes were exposed to @entity6 mustard ( @entity7 ) vapor (370, 420 microg/l) for a period of two minutes. A three months follow-up study was carried out, based on the evaluation of clinical, biochemical and histological parameters. RESULTS: @entity7 exposure initiated typical clinical symptoms within 2-6 hrs, characterized by eye closure, @entity1 , @entity10 , @entity9 and @entity2 . The clinical signs were significantly dose-dependent and reached a peak at 24--72 hrs post exposure. Biochemical evaluation of the aqueous humor exhibited an inflammatory reaction and oxidative stress at 4 hrs after exposure, subsiding at 28 hrs after exposure. Histological examination of corneas at 48 hrs revealed epithelial denudation and marked stromal @entity1 , accompanied by cellular infiltration. Epithelial regeneration started after 72 hrs, and recovery was almost completed within 1--2 weeks, depending on the @entity7 dose. A second phase of pathological processes started as early as two weeks post exposure and was characterized by @entity12 , @entity5 , recurrent @entity8 . The delayed @entity4 were found in 25 and 40% of the eyes respectively, and when appearing, were more severe than the initial ones. CONCLUSIONS: The development of @entity7 -induced @entity11 in @entity3 is similar to the lesions described in @entity0 casualties. Quantitative analysis of the various clinical parameters emphasizes the contribution of each tissue to the overall toxic picture. Our experimental model is useful for studying the pathological mechanisms of @entity11 , and may serve for testing potential therapies.

title: Characterization of acute and delayed @entity11 induced by XXXX mustard in @entity3 .

answer: @entity6


abstract: OBJECTIVE: The majority of research on @entity0 risk and @entity2 ( @entity2 ) has been conducted for blacks and whites. This study evaluates the relationship between @entity2 and @entity0 incidence in @entity3 for four race/ethnic groups. METHODS: Principal component analysis was used to create an @entity2 index using 1990 Census data. Untracted cases were randomly allocated to census block groups within their county of residence. A total of 97,227 female @entity0 cases diagnosed in @entity3 between 1988 and 1992 were evaluated. Incidence rates and rate ratios (RRs) were estimated and a chi2 test for trend across @entity2 levels was performed. RESULTS: @entity2 was positively related to @entity0 incidence, and this effect was stronger for Hispanics and Asian/others than for whites and blacks. Adjusting by @entity2 did not eliminate the differences in @entity0 rates among race/ethnic groups. RR differences between the race/ethnic groups were greatest in the lowest @entity2 category and attenuated with increasing @entity2 . An increasing trend over @entity2 was statistically significant for all race/ethnic groups. Including randomly allocated cases affected RR estimates for white @entity1 only. CONCLUSIONS: Our results are consistent with similar findings for the Los Angeles area but differ from previous results for the San Francisco Bay area.

title: Socioeconomic status and XXXX incidence in @entity3 for different race/ethnic groups.

answer: @entity0


abstract: BACKGROUND: This study reports on the effects of botulinum toxin A (BoNT-A) injections in the upper extremity (UE) in @entity0 with unilateral @entity2 (uCP) combined with bimanual task-oriented therapy (BITT) or either treatment modality performed separately. Bimanual activities were measured with the @entity3 ( @entity3 ), the ABILHand-Kids questionnaire (AK), the Observational Skills Assessment Score (OSAS). Goal achievement was measured with Goal Attainment Scaling (GAS), using blind video assessment, and the Canadian Occupational Performance Measure (COPM). METHODS: Thirty-five @entity0 , mean age 7.14 years ( @entity1 2.63), 11 Manual Ability Classification Score (MACS) I, 15 MACS II and 9 MACS III, participated. The trial started with four study groups: BoNT-A-only (n = 5), BITT-only (n = 11), BoNT-A +   BITT (n = 13), and control (n = 6). Twenty-two @entity0 were randomised, 13 @entity0 received their parents' preferred treatment: BoNT-A +   BITT or BITT-only. Three comparisons were analysed: BITT (BoNT-A +   BITT and BITT-only; n = 24) versus no BITT (BoNT-A-only and control; n = 11), BoNT-A (BoNT-A-only and BoNT-A +   BITT; n = 18) versus no BoNT-A (BITT-only and control; n = 17), and the additional effect of BoNT-A (BoNT-A +   BITT versus BITT-only). Follow-up time: 24 weeks. RESULTS: No significant differences between the groups were found on the @entity3 . The amount of use of both hands on the OSAS was significantly better in the BoNT-A group in the beading and sandwich-making task. The BoNT-A group also showed significant improvement in the quality scores of the OSAS: the wrist position during grasping and holding, especially in the younger @entity0 . The BITT group improved significantly on the AK and significantly more on the performance and satisfaction scores of the COPM at 12 and 24 weeks regarding several goals. BoNT-A showed a significant negative effect at 12 and 24 weeks in the most important goal. BITT, more than BoNT-A   +   BITT, showed positive effects on the GAS score at 12 (significant), 18 and 24 weeks. CONCLUSIONS: BoNT-A has a positive effect on quality of movement and amount of use of the affected UE during the 3 months' working time. BoNT-A has no additional effect on bimanual performance and goal achievement. BITT has a positive effect on goal achievement and bimanual performance, even up to 6 weeks after therapy had stopped. TRIAL REGISTRATION: Current Controlled Trials ISRCTN69541857.

title: Effects of botulinum toxin A and/or bimanual task-oriented therapy on upper extremity activities in unilateral XXXX : a clinical trial.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: @entity1 still has a dismal prognosis. Radical surgery is by far the most successful treatment but most @entity0 are not operable at the time of diagnosis and for these @entity0 external beam radiotherapy with or without concurrent chemotherapy offers the best choice for cure or palliation. In @entity0 with advanced @entity1 , intraluminal brachytherapy has been proposed as a complementary method to increase local control. @entity0 AND METHODS: Between 1989 and 1999, 40 @entity0 with inoperable @entity1 were treated with combined external and intraluminal radiation therapy in Turku University Central Hospital. The external radiation was performed with a median total dose of 40 Gy given in 20 fractions. On the average a week after the external radiation a median total dose of 10 Gy intraluminal radiation therapy was given in 4 fractions. RESULTS: The intraluminal brachytherapy could be performed without technical difficulties and no major complications were seen. In many cases (16 out of 40 @entity0 , 40%), the symptoms could be relieved immediately and in most cases the progression of the disease could be delayed as evidenced by post-treatment serial endoscopy. No major complications were encountered. The 1- and 2-year survival rates were 30 and 17.5%, respectively. All @entity0 alive at 2 years can be considered as long-term survivors. Median follow-up was 86 months. CONCLUSIONS: Intraluminal brachytherapy is a safe and efficient treatment modality which offers a potential means of cure for selected @entity0 with @entity1 .

title: Combined external and intraluminal radiotherapy in the treatment of advanced XXXX .

answer: @entity1


abstract: BACKGROUND: The outcome of @entity4 for @entity3 in young adults performed at the Wellington Hospital (Wellington, New Zealand) was reviewed. METHODS: Seventeen @entity0 underwent 21 proximal femoral osteotomies for the treatment of @entity3 at Wellington Hospital between 1992 and 1999. Thirteen @entity0 (17 hips) were contacted and were able to complete a questionnaire form specific for @entity1 and function. RESULTS: There was a response rate of 76.5% (13 out of a possible 17 @entity0 undergoing @entity4 ) at a mean 3 years 4 months postoperatively. Of these, one @entity0 has had a total hip joint replacement and one @entity0 is currently on the waiting list for a total hip joint replacement. Three other @entity0 (three hips) report moderate or severe @entity1 . The remaining eight @entity0 (12 hips) report having mild or no @entity1 . Questionnaire results show a postoperative decrease in @entity1 in most @entity0 . Hip function as assessed by the questionnaire was essentially unchanged. CONCLUSIONS: @entity4 is a satisfactory option for young @entity0 with @entity2 . The operation is only likely to be useful in the treatment of @entity1 .

title: @entity4 for the treatment of XXXX in young adults.

answer: @entity3


abstract: Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after @entity3 injection into the whisker pad (WP), masseter muscle (MM), @entity1 ( @entity1 ) or sternohyoideus muscle (SM). The pERK-IR cells also showed NeuN immunoreactivity, indicating that ERK phosphorylation occurs in neurons. The pERK-IR cells were significantly reduced after intrathecal injection of @entity5 inhibitor @entity4 . The pERK-IR cells expressed bilaterally in the Vc and C1-C2 after @entity3 injection into the unilateral @entity1 or SM, whereas unilaterally in the Vc and C1-C2 after unilateral WP or MM injection. After @entity3 injection into the WP or MM, the pERK-IR cell expression in the Vc was restricted rostrocaudally within a narrow area. However, the distribution of pERK-IR cells was more wide spread without a clear peak in the Vc and C1-C2 after @entity3 injection into the @entity1 or SM. In the NTS, the unimodal pERK-IR cell expression peaked at 0-720 m rostral from the obex following @entity3 injection into WP, MM, @entity1 or SM. In the ipsilateral Pa5, many pERK-IR cells were observed following @entity3 injection into the SM. The number of swallows elicited by distilled water administration was significantly smaller after @entity3 injection into the WP, MM or @entity1 but not SM compared to that of vehicle-injected @entity0 . Various noxious inputs due to the masticatory or swallowing-related @entity1 may be differentially involved in @entity2 and swallowing reflex activity.

title: Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following @entity3 injection into masticatory and swallowing-related muscles in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity2 ( @entity2 ) may improve beta cell function by mechanisms other than caloric restriction and body @entity1 . We aimed to assess the impact of anatomical and hormonal alterations specific to @entity2 on @entity3 homeostasis, b cell function and morphology. METHODS: Male Zucker(fa/fa) @entity0 underwent either @entity2 (n   =   11) or sham surgeries (n   =   10). Five of the shams were then food restricted and body weight matched (BWM) to the @entity2 @entity0 . Six male Zucker(fa/+) @entity0 underwent sham surgery and served as additional lean controls. Twenty-seven days after surgery, an oral @entity3 tolerance test (OGTT) was performed and plasma levels of @entity3 , insulin and glucagon-like peptide-1 ( @entity5 ) were measured. Immunohistological analysis of pancreatic islets was performed, and @entity6 and @entity7 mRNA content were quantified. RESULTS: Shams consumed more food and gained more weight compared to both @entity2 and BWM (p   <   0.001). Hyperglycaemia was evident in ad libitum-fed shams, whilst postprandial @entity3 levels were lower in @entity2 compared to the BWM sham group (p   <   0.05). During the OGTT, @entity2 @entity0 responded with >2.5-fold increase of @entity5 . Histology revealed signs of @entity4 in ad libitum-fed shams, but not in @entity2 and sham BWM controls (p   <   0.001). @entity6 and @entity7 mRNA content was similar between the @entity2 and BWM shams but higher compared to ad libitum shams (p   <   0.05). CONCLUSIONS: Combined molecular, cellular and histological analyses of pancreatic function suggest that @entity1 alone, and not the enhancement of @entity5 responses, is predominant for the short-term b cell protective effects of @entity2 .

title: Gastric Bypass-Related Effects on XXXX Control, b Cell Function and Morphology in the Obese Zucker @entity0 .

answer: @entity3


abstract: @entity6 , a strong alpha-adrenergic receptor-stimulating agent, was compared with @entity4 in 65 @entity0 with out-of-hospital @entity2 , in a double-blind study. The resuscitation was performed by the physician-staffed Prehospital Emergency Care Unit of Helsinki University Central Hospital. The @entity0 received either 1.0 mg of @entity6 or 0.5 mg of @entity4 i.v. in the treatment of fine @entity5 , @entity2 or electromechanical dissociation. If two doses of either drug did not restore circulation, 0.5 mg of known 0.01% @entity4 was given i.v., maximally twice. In the @entity4 group, which consisted of 36 @entity0 with a mean age of 61 years, 10 @entity0 (28%) were successfully resuscitated. The @entity6 group consisted of 29 @entity0 with a mean age of 62 years. In this group nine @entity0 (31%) were successfully resuscitated. The two groups were comparable regarding their apnoea-times, and there was no difference in the need for extra @entity4 between the groups. No adverse effects, such as @entity1 or @entity3 , were noted in the @entity0 treated with either @entity4 or @entity6 , nor did the overall rate of successful resuscitation fall during the test period. It is concluded that @entity6 seems as effective as @entity4 in the treatment of @entity2 , but further studies seem warranted.

title: Comparison of @entity4 and XXXX in out-of-hospital cardiopulmonary resuscitation. A double-blind study.

answer: @entity6


abstract: PURPOSE: We used @entity10 magnetic resonance spectroscopy (MRS) and near-infrared spectroscopy (NIRS) as a means of quantifying abnormalities in @entity4 muscle oxygenation and @entity7 ( @entity7 ) turnover in @entity8 ( @entity8 ). METHODS: Eleven male @entity0 with @entity8 (mean age, 65 years; range, 55-76 years) and nine male control subjects of similar age were observed in a case-control study in vascular outpatients. Inclusion criteria were more than 6 months' @entity4 @entity6 (median, 1.5 years; range, 0.6-18 years); proven femoropopliteal or iliofemoral occlusive or stenotic disease; maximum treadmill walking distance (2 km/h, 10 degrees gradient) of 50 to 230 m (mean, 112 m); ankle-brachial pressure index of 0.8 or less during exercise (mean, 0.47; range, 0.29-0.60). Exclusion criteria included @entity1 , @entity5 , and magnet contraindications. Simultaneous @entity10 MRS and NIRS of lateral gastrocnemius was conducted during 2 to 4 minutes of voluntary 0.5 Hz isometric plantarflexion at 50% and 75% maximum voluntary contraction force (MVC), followed by 5 minutes recovery. Each subject was studied three times, and the results were combined. RESULTS: Compared with control subjects, @entity0 with @entity8 showed (1) normal muscle cross-sectional area, MVC, @entity7 turnover, and contractile efficiency ( @entity7 turnover per force/area); (2) larger @entity9 (PCr) changes during exercise (ie, increased shortfall of oxidative @entity7 synthesis) and slower PCr recovery (47% +/- 7% [mean +/- SEM] decrease in functional capacity for oxidative @entity7 synthesis, P = .001); (3) faster deoxygenation during exercise and slower postexercise reoxygenation (59% +/- 7% decrease in rate constant, P = .0009), despite reduced oxidative @entity7 synthesis; (4) correlation between PCr and NIRS recovery rate constants (P < .02); and (5) correlations between smaller walking distance, slower PCr recovery, and reduced MVC (P < .001). The precision of the key measurements (rate constants and contractile efficiency) was 12% to 18% interstudy and 30% to 40% intersubject. CONCLUSION: The @entity3 in @entity2 supply dominates muscle metabolism. Reduced force-generation in @entity0 who are affected more may protect muscle from metabolic stress.

title: Mitochondrial function and XXXX supply in normal and in chronically ischemic muscle: a combined 31P magnetic resonance spectroscopy and near infrared spectroscopy study in vivo.

answer: @entity2


abstract: Peak-ratio interference pattern analysis (peak-ratio method) is said to have a high sensitivity and to be independent of sex and age. This study was carried out to prove or disprove these findings. The peak-ratio method and qualitative motor unit action potential (MUAP) analysis were applied to the right brachial biceps and anterior tibial muscles of 44 healthy subjects, aged 23-87 years, 25 @entity1 @entity0 , aged 21-83 years, and 29 @entity2 @entity0 , aged 19-70 years. Peak-ratio parameters were independent of sex and age. They tended to be lower in the anterior tibial muscle than in the brachial biceps muscle. @entity1 @entity0 typically showed decreased peak-ratio, short time intervals and increased amplitude/turn. @entity2 @entity0 typically showed increased peak-ratio, turns/s and short time intervals. The sensitivity of the peak-ratio method was 72% for @entity1 @entity0 and 59% for @entity2 @entity0 . The sensitivity of the peak-ratio method was similar to that of the MUAP analysis in @entity1 @entity0 and higher than that of the MUAP analysis in @entity2 @entity0 . The specificity of the peak-ratio method was 80%. The peak-ratio method proved to be a valuable, supplementary electromyographic tool for the detection of @entity3 .

title: Peak-ratio interference pattern analysis in the detection of XXXX .

answer: @entity3


abstract: CONTEXT: @entity3 in hospitalized @entity0 is associated with increased morbidity and mortality. OBJECTIVE: We examined whether @entity2 is more strongly associated with relative or @entity3 . DESIGN: The study was an observational cohort study. @entity0 AND SETTING: A total of 2290 @entity0 acutely admitted to a tertiary hospital. MAIN OUTCOME MEASURE: The relative @entity3 ( @entity3 ratio [SHR]) was defined as admission @entity1 divided by estimated average @entity1 derived from glycosylated hemoglobin. The relationships between @entity1 and SHR with @entity2 (in-hospital death or critical care) were examined. RESULTS: In univariable analyses, SHR (odds ratio, 1.23 per 0.1 increment [95% confidence interval, 1.18-1.28]; P < .001) and @entity1 (odds ratio, 1.18 per mmol/L [1.13-1.23]; P < .001) were associated with @entity2 . In multivariable analysis, the association was maintained for SHR (odds ratio, 1.20 per 0.1 increment [1.13-1.28]; P < .001), but not @entity1 (odds ratio, 1.03 per mmol/L [0.97-1.11]; P = .31). Background @entity3 affected the relationship between @entity1 (P = .002) and @entity2 , but not SHR (P = .35) and @entity2 . In @entity0 with admission @entity1  <=10 mmol/L, the odds ratio for @entity2 was higher in the fourth (2.4 [1.4-4.2]; P = .001) and fifth (3.9 [2.3-6.8]; P < .001) SHR quintiles than in the lowest SHR quintile. CONCLUSIONS: SHR controls for background glycemia and is a better biomarker of @entity2 than @entity3 . SHR identifies @entity0 with relative @entity3 at risk of @entity2 . Future studies should explore whether basing @entity1 -lowering therapy on relative, rather than absolute, @entity3 improves outcomes in hospitalized @entity0 .

title: Relative XXXX , a Marker of @entity2 : Introducing the Stress @entity3 Ratio.

answer: @entity3


abstract: BACKGROUND AND AIMS: There are no studies that compared the effects of different intensities of statin treatment on the long-term outcome of @entity0 with recent @entity2 . We aimed to evaluate these effects. METHODS: We prospectively studied 436 consecutive @entity0 who were discharged after acute @entity2 (39.2% males, age 78.6      6.7 years). Statin treatment was categorized in equipotent doses of @entity4 . One year after discharge, the functional status was assessed with the modified Rankin scale (mRS). Adverse outcome was defined as mRS between 2 and 6. The occurrence of @entity2 , @entity3 and @entity1 was recorded. RESULT: Adverse outcome rates were lower in @entity0 treated with @entity4 20  mg/day or more potent doses of statins than in @entity0 treated with @entity4 10  mg/day (63.5, 38.2 and 48.2%, respectively; p  =  0.004). In binary logistic regression analysis, independent predictors of adverse outcome were the mRS at discharge (relative risk (RR) 2.33, 95% confidence interval (CI) 1.77-3.07, p  <  0.001) whereas more aggressive treatment with statins independently predicted favorable outcome ( @entity4 20 vs. 10  mg/day, RR 0.30, 95% CI 0.11-0.87, p  =  0.026; @entity4 40  mg/day or more potent dose of statins vs. @entity4 10  mg/day, RR 1.66, 95% CI 0.62-4.44, p  =  NS). The incidence of cardiovascular events and all-cause mortality showed a trend for being lower in @entity0 treated with @entity4 40-80  mg/day or @entity6 10-40  mg/day than in those treated with less potent doses of statins. CONCLUSION: More aggressive @entity5 treatment improves the long-term functional outcome of @entity0 with acute @entity2 more than less aggressive treatment.

title: Comparative effects of more versus less aggressive treatment with statins on the long-term outcome of XXXX with acute @entity2 .

answer: @entity0


abstract: AIM: To retrospectively evaluate the diagnostic efficacy of interventional digital subtraction angiography (DSA) for @entity7 small bowel @entity8 ( @entity8 ). METHODS: Between January 2006 and December 2013, small bowel @entity2 in 25 consecutive @entity0 undergoing emergency interventional DSA were histopathologically confirmed as GIST after surgical resection. The medical records of these @entity0 and the effects of interventional DSA and the presentation and management of the condition were retrospectively reviewed. RESULTS: Of the 25 @entity0 with an age range from 34- to 70-year-old (mean: 54    12 years), 8 were male and 17 were female. Obscure @entity4 , including tarry or bloody stool and intermittent melena, was observed in all cases, and one case also involved hematemesis. Nineteen @entity0 required acute blood transfusion. There were a total of 28 small bowel @entity2 detected by DSA. Among these, 20 were located in the jejunum and 8 were located in the ileum. The DSA characteristics of the @entity8 included a hypervascular mass of well-defined, homogeneous enhancement and early developed draining veins. One case involved a complication of intussusception of the small intestine that was discovered during surgery. No @entity13 , @entity12 or fistulae, or @entity5 were observed. The completely excised size was approximately 1.20 to 5.50 cm (mean: 3.05    1.25 cm) in maximum diameter based on measurements after the resection. There were @entity9 (n = 8), @entity11 (n = 10), @entity6 and @entity1 (n = 10) on the intra-luminal side of the @entity2 . @entity2 in @entity0 with a large amount of @entity3 were treated with transcatheter @entity10 with gelfoam particles during interventional DSA. CONCLUSION: Emergency interventional DSA is a useful imaging option for locating and diagnosing small bowel @entity8 in @entity0 with @entity7 , and is an effective treatment modality.

title: Interventional digital subtraction angiography for small bowel XXXX with @entity7 .

answer: @entity8


abstract: BACKGROUND: Long-term results of the posterior approach (PA) for the treatment of popliteal artery @entity8 are lacking in the literature. We reviewed our experience during a 13-year period in @entity0 with popliteal artery @entity8 , comparing those treated through a PA with those operated on through a standard @entity13 ( @entity13 ). METHODS: Clinical data of all @entity0 treated between February 1998 and October 2011 were retrospectively reviewed and outcomes analyzed. The Kaplan-Meier method was used to estimate survival, and   (2), Wilcoxon, and log-rank tests were used for analysis. RESULTS: A total of 77 @entity8 were treated in 65 @entity0 (64 @entity0 ). Mean age was 68  years (range, 48-96  years). Thirty-six @entity8 were asymptomatic (47%). Mean sac diameter was 2.8     1  cm. A PA was used in 43 PAAs (55%) and an @entity13 in 34. The PA and @entity13 @entity0 differed significantly in age (median being older), smoking history (more frequent in PA), and @entity4 and @entity2 (higher for @entity13 ). In 42 cases the @entity8 was symptomatic (54.5%) for chronic @entity1 , with @entity9 in 18 @entity0 , acute @entity1 in 17, @entity12 in 3, compression on adjacent structures in 3, and @entity7 with severe acute @entity3 in 1. All PA repairs consisted of aneurysmectomy with an interposition graft with end-to-end anastomoses; among @entity13 repairs, 22 interposition grafts and 12 bypasses were performed. A @entity11 graft was used in 54 cases. Five @entity0 had an early @entity10 (two PA and three @entity13 ). No perioperative @entity5 occurred. Two @entity0 sustained a permanent (PA) and a temporary ( @entity13 ) peroneal @entity2 . There were no early amputations. The median in-hospital stay was longer for @entity13 (10  days) than for PA (7  days; P  = .02). Median follow-up was 58.8  months (range, 5 days-166 months). Nine @entity0 died during follow-up of unrelated causes. The 5-year primary and secondary patency rates were 59.6%     8.6% and 96.5%     3.4%, respectively, for PA, and 65.1%     11.1% and 79.4%     9.7%, respectively, for @entity13 (P  = .53 for primary patency rate and P  = .22 for secondary patency rate). Limb salvage was 100% at 5  years and 93.3%     6.4% at 10  years for PA and 91.1%     6.3% at both time points for @entity13 (P  = .28). CONCLUSIONS: PA and @entity13 both achieved satisfactory results in primary and secondary patency rates, as well as limb salvage, during long-term follow-up. The differences between the two groups were small and not statistically significant. PA was burdened by similar @entity6 compared with @entity13 . The in-hospital stay after PA was significantly lower.

title: Comparison of posterior and medial approaches for  popliteal artery XXXX .

answer: @entity8


abstract: BACKGROUND: Despite current recommendations, many @entity0 with @entity2 do not receive annual vaccination against @entity3 , partly because of concern that vaccine may trigger exacerbations. Colds can trigger exacerbations, which may be mistaken for vaccine-related adverse events. We undertook a double-blind placebo-controlled multicentre crossover study to assess the safety of @entity3 vaccine in @entity0 with @entity2 , with allowance for the occurrence of colds. METHODS: We studied 262 @entity0 , aged 18-75 years, who recorded daily peak expiratory flow (PEF), respiratory symptoms, medication, medical consultations, and hospital admissions for 2 weeks before the first injection and until 2 weeks after the second injection. Order of injection (vaccine and placebo) was assigned randomly. There was an interval of 2 weeks between injections. The main outcome measure was an exacerbation of @entity2 within 72 h of injection (defined as a fall in PEF of >20%). FINDINGS: Among 255 @entity0 with paired data, 11 recorded a fall in PEF of more than 20% after vaccine compared with three after placebo (McNemar's test p=0.06); a fall of more than 30% was recorded by eight after vaccine compared with none after placebo (binomial test p=0.008). However, when @entity0 with colds were excluded, there was no significant difference in the numbers with falls of more than 20% between vaccine and placebo (six vs three; binomial test p=0.51), although the difference for PEF decreases of more than 30% approached significance (five vs none; binomial test, p=0.06). This association was confined to first-time vaccinees. INTERPRETATION: Our findings indicate that @entity1 may occur as a complication of @entity3 vaccination. However, the risk of @entity1 is very small and outweighed by the benefits of vaccination.

title: Randomised placebo-controlled crossover trial on effect of inactivated XXXX vaccine on pulmonary function in @entity2 .

answer: @entity3


abstract: Avian paramyxovirus serotype 2 ( @entity3 -2) is one of the nine serotypes of @entity3 , which infect a wide variety of avian species around the world. In this study, we constructed a reverse genetics system for recovery of infectious recombinant @entity3 -2 strain Yucaipa ( @entity3 -2/Yuc) from cloned cDNA. The rescued recombinant virus (rAPMV-2) resembled the biological virus in growth properties in vitro and in pathogenicity in vivo. The reverse genetics system was used to analyze the role of the cleavage site of the fusion (F) protein in viral replication and pathogenesis. The cleavage site of @entity3 -2/Yuc (KPASR   F) contains only a single basic residue (position -1) that matches the preferred furin cleavage site [RX(K/R)R   ]. (Underlining indicates the basic @entity1 at the F protein cleavage site, and the arrow indicates the site of cleavage.) Contrary to what would be expected for this cleavage sequence, @entity3 -2 does not require, and is not augmented by, exogenous protease supplementation for growth in cell culture. However, it does not form syncytia, and the virus is avirulent in @entity2 . A total of 12 @entity3 -2 mutants with F protein cleavage site sequences derived from @entity3 serotypes 1 to 9 were generated. These sites contain from 1 to 5 basic residues. Whereas a number of these cleavage sites are associated with protease @entity0 and lack of syncytium formation in their respective native viruses, when transferred into the @entity3 -2 backbone, all of them conferred protease independence, syncytium formation, and increased replication in cell culture. Examination of selected mutants during a pulse-chase experiment demonstrated an increase in F protein cleavage compared to that for wild-type @entity3 -2. Despite the gains in cleavability, replication, and syncytium formation, analysis of viral pathogenicity in 9-day-old embryonated @entity2 eggs, 1-day-old chicks, and 2-week-old @entity2 showed that the F protein cleavage site mutants did not exhibit increased pathogenicity and remained avirulent. These results imply that structural features in addition to the cleavage site play a major role in the cleavability of the F protein and the activity of the cleaved protein. Furthermore, cleavage of the F protein is not a determinant of @entity3 -2 pathogenicity in @entity2 .

title: Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 2 increase cleavability and syncytium formation but do not increase viral virulence in XXXX .

answer: @entity2


abstract: A multicenter retrospective review was performed analyzing 1081 primary total hip replacements in 944 @entity0 using the Harris Galante-I cementless acetabular component with screw fixation. All @entity0 were followed up for a minimum of 5 years with a mean followup of 81 months. Linear @entity2 wear averaged 0.11 mm/year (range, 0-0.86 mm/year). @entity1 was seen in 25 @entity0 (2.3%). Migration of the acetabular component was seen in four hips. A subgroup of @entity0 was reanalyzed at a minimum followup of 10 years. The mean linear @entity2 wear rate remained 0.11 mm/year. In this group, only one socket had migrated. There was an association between wear rate and age. On average, younger @entity0 had higher wear rates. The risk for having @entity1 develop and the need for revision surgery also was age-related. Twenty-two percent of hip replacements (15 hips) in @entity0 younger than 50 years of age at the time of their index operation had @entity1 develop. In contrast, for @entity0 older than 50 years of age at the time of surgery only 7.8% (eight hips) had @entity3 of the pelvis develop. For @entity0 older than 70 years of age at the time of primary total hip replacement, none had @entity1 develop.

title: Fixation, XXXX wear, and @entity1 in primary total hip replacement.

answer: @entity2


abstract: The molecular events regulating hormone-induced oocyte activation and meiotic maturation are probably best understood in @entity0 . In @entity0 , @entity1 activates the G2-arrested oocyte, induces entry into M phase of meiosis I (MI) and resumption of the meiotic cell cycles, and leads to the formation of a mature, fertilizable egg. Oocytes of @entity3 offer several practical advantages over those of @entity0 , including faster and more synchronous meiotic cell cycle progression, less seasonal variability, and the availability of transgenic approaches. Previous work found several similarities in the pathways regulating oocyte maturation in the two species. Here, we report several additional ones that are conserved in @entity3 . (1). Injection of @entity4 mRNA into G2-arrested oocytes activates the MAP kinase cascade and induces the G2/MI transition. (2). Injection of the beta subunit of the kinase CK2 (a negative regulator of @entity4 and oocyte activation) delays the G2/MI transition. (3). Elevating PKA activity blocks @entity1 -induced maturation; repressing PKA activity induces entry into MI in the absence of @entity1 . (4). LF ( @entity2 lethal factor), which cleaves certain MAP kinase kinases, strongly reduces both the rate and extent of entry into MI. In contrast to the one previously reported major difference between oocytes of the two species, we find that injection of egg cytoplasm ("MPF activity") into G2-arrested @entity3 oocytes induces entry into meiosis I even when protein synthesis is blocked, just as it does in oocytes of @entity0 . These results indicate that much of what we have learned from studies of @entity0 oocytes holds for those of @entity3 , and suggest that @entity3 oocytes offer a good experimental system for investigating certain questions that require a rapid, synchronous progression through the G2/meiosis I transition.

title: Regulation of the G2/M transition in oocytes of XXXX .

answer: @entity3


abstract: Effective therapeutic options for @entity0 living with @entity8 are limited. The @entity3 relieving effect of cannabinoids remains unclear. A systematic review of randomized controlled trials (RCTs) examining cannabinoids in the treatment of chronic non- @entity1 @entity3 was conducted according to the PRISMA statement update on the QUORUM guidelines for reporting systematic reviews that evaluate health care interventions. Cannabinoids studied included smoked @entity6 , oromucosal extracts of @entity6 based medicine, @entity9 , @entity7 and a novel @entity7 analogue. Chronic non- @entity1 @entity3 conditions included @entity2 , @entity4 , @entity5 , and mixed @entity8 . Overall the quality of trials was excellent. Fifteen of the eighteen trials that met the inclusion criteria demonstrated a significant analgesic effect of cannabinoid as compared with placebo and several reported significant improvements in sleep. There were no serious adverse effects. Adverse effects most commonly reported were generally well tolerated, mild to moderate in severity and led to withdrawal from the studies in only a few cases. Overall there is evidence that cannabinoids are safe and modestly effective in @entity2 with preliminary evidence of efficacy in @entity4 and @entity5 . The context of the need for additional treatments for @entity8 is reviewed. Further large studies of longer duration examining specific cannabinoids in homogeneous populations are required.

title: Cannabinoids for treatment of chronic non- @entity1 XXXX ; a systematic review of randomized trials.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: The enrollment yield and reasons for screen failure in @entity1 trials have not been well delineated. METHODS: The Field Administration of @entity1 Therapy- @entity3 (FAST-MAG) trial identified @entity0 for enrollment using a 2 stage screening process-paramedics in @entity0 followed by physician-investigators by cell phone. Outcomes of consecutive screening calls from paramedics to enrolling physician-investigators were prospectively recorded. RESULTS: From 2005 to 2012, 4458 phone calls were made by paramedics to physician-investigators, an average of 1 call per vehicle every 135.7 days. A total of 1700 (38.1%) calls resulted in enrollments. The rate of enrollment of @entity1 mimics was 3.9%. Among the 2758 @entity0 not enrolled, 3140 reasons for screen failure were documented. The most common reasons for nonenrollment were >2 hours from last known well (17.2%), having a @entity2 causing disability (16.1%), and absence of a consent provider (9.5%). Novel barriers for phone informed consent specific to the prehospital setting were infrequent, but included: cell phone connection difficulties (3.2%), @entity0 being hard of hearing (1.4%), insufficient time to complete consent (1.3%), or severely dysarthric (1.3%). CONCLUSIONS: In this large, multicenter prehospital trial, nearly 40% of every calls from the field to physician-investigators resulted in trial enrollments. The most common reasons for nonenrollment were out of window last known well time, prestroke confounding medical condition, and absence of a consent provider. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059332.

title: Enrollment Yield and Reasons for Screen Failure in a Large XXXX Trial.

answer: @entity1


abstract: PURPOSE: @entity14 is a very rare @entity4 that is usually present in infancy with transfusion dependent @entity15 and multiorgan involvement including exocrine @entity2 . The disease is secondary to a mitochondrial DNA deletion that is variable in size and location. @entity13 can develop, but are usually not part of the initial presentation. We report two @entity0 who presented with unusual endocrine manifestations, @entity1 and @entity10 , who were both later diagnosed with @entity14 . METHODS: Medical records were reviewed. Confirmatory testing included: mitochondrial DNA deletion testing and sequencing of the breakpoints, muscle biopsy, and bone marrow studies. RESULTS: Case 1 presented with @entity12 requiring insulin at birth. She had several episodes of @entity9 triggered by stress and labile blood @entity6 control. Workup for genetic causes of @entity1 was negative. She had transfusion dependent @entity7 and died at 24 months due to @entity8 . Case 2 presented with @entity10 and @entity7 during @entity5 , requiring @entity3 replacement since 37 months of age. He is currently 4 years old and has mild @entity7 . Mitochondrial DNA studies confirmed a 4.9 kb deletion in @entity0 1 and a 5.1 kb deletion in @entity0 2. CONCLUSION: The @entity0 reported highlight the importance of considering mitochondrial DNA disorders in @entity0 with @entity13 , and expand the knowledge about this rare @entity11 .

title: @entity14 : unique endocrine manifestations including @entity1 and XXXX .

answer: @entity10


abstract: Binding of phenyl derivative of pyranocoumarin (PDP) modulated activity of fungal endopolygalacturonase in silico. Induced fit docking study of PDP with endopolygalacturonase (1HG8) showed a bifurcated @entity3 bond interaction with the protein at Lys 244 with a docking score of -3.6 and glide energy of -37.30  kcal/mol. Docking with endopolygalacturonase II (1CZF) resulted @entity3 bond formation with Lys 258 with a docking score of -2.3 and glide energy of -30.42  kcal/mol. It was hypothesized that this modulation favors accumulation of cell wall fragments (oligogalacturonides) which act as elicitors of plant defense responses. In order to prove the same, in vivo studies were carried out using a formulation developed from PDP (PDP 5EC) on greenhouse grown @entity1 L. The formulation was effective at different concentrations in reduction of seed @entity0 , improvement of vigor and control of @entity5 @entity6 . lycopersici @entity0 in @entity1 . At a concentration of 2  %, PDP 5EC significant reduction in seed @entity0 (95.83  %), improvement in seed vigor (64.31  %) and control of @entity5 @entity6 . lycopersici @entity0 (96.15  %) were observed. Further application of PDP 5EC to @entity1 challenged with @entity5 @entity6 . lycopersici significantly increased the activity of enzymes of the phenylpropanoid pathway, namely, peroxidase (PO), @entity4 oxidase (PPO), @entity2 ammonia lyase (PAL), and enhanced the total phenolic content when compared to the control.

title: Phenyl Derivative of Pyranocoumarin Precludes @entity5 XXXX . lycopersici Infection in @entity1 via Induction of Enzymes of the Phenylpropanoid Pathway.

answer: @entity6


abstract: OBJECTIVE: To evaluate the cost-effectiveness of @entity3 ( @entity3 ) compared with radionuclide bone scan in the evaluation of @entity0 with clinically suspected @entity1 . DESIGN: The medical records of all @entity0 who had been seen in the emergency room over a 4 1/2 year period with a clinically suspected @entity1 , negative or equivocal plain films, and either a subsequent bone scan or @entity3 examination were retrospectively reviewed. The time to diagnosis, admission rate, and time to surgery were determined. A two-sample t-test was used to assess the statistical significance of the results. A theoretical cost analysis was performed using current charges to estimate all expenses. @entity0 : Forty @entity0 (11 male, 29 female; age 28-99 years) satisfied our inclusion criteria. RESULTS AND CONCLUSIONS: Twenty-one @entity0 had bone scans (six with @entity2 ), and 19 had @entity3 (four with @entity2 ). The time to diagnosis was 2.24 +/- 1.30 days for bone scanning and 0.368 +/- 0.597 days for @entity3 (P < 0.0001). Twenty @entity0 in the bone scan group were admitted compared with 13 in the @entity3 group. The time to surgery was at least 1 day longer in @entity0 undergoing bone scanning. Bone scanning resulted in higher @entity0 costs compared with @entity3 because of the delay in diagnosis. In the evaluation of @entity0 with suspected @entity1 , early @entity3 is more cost-effective than delayed bone scanning. Further prospective studies comparing the cost-effectiveness of early @entity3 with early bone scanning are needed.

title: Magnetic resonance imaging: a cost-effective alternative to bone scintigraphy in the evaluation of XXXX with suspected @entity1 .

answer: @entity0


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a well-differentiated @entity2 that accounts for approximately 80% of @entity2 cases. On other hand, @entity3 ( @entity3 ) is a less frequent, but aggressive subtype, with poor prognosis. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as potent post-transcriptional regulators of gene expression, which modulate the expression of @entity0 -related genes. Computational analyses estimate that a single miRNA may modulate hundreds of mRNA targets and, at the same time, cooperate with others to regulate one single mRNA transcript. Due to the large number of predicted targets and possible interactions, only a small number of miRNAs have characterized biological roles, and the panorama of miRNA-mediated regulation in @entity2 remains to be understood. Taking into consideration the large amount of gene expression data deposited in public databases we aligned miRNA target prediction and gene expression data from public @entity4 and @entity3 datasets to construct a network of post-transcriptional regulation in @entity2 . After a gene set enrichment analysis we identified signaling pathways and biological processes potentially modulated by the miRNAs deregulated in @entity4 and @entity3 . Our results show miRNA-mRNA interaction that could contribute with the de-regulation of key @entity0 -host mediators, such as extra-cellular matrix molecules, interleukins and interleukin receptors, which could drive a more @entity1 and @entity0 progression. Moreover, our analysis through The @entity0 (TCGA) database revealed that aberrant expression of @entity5 and cytokines genes is frequent in @entity4 and is associated with @entity1 and decreased overall survival rate. In conclusion, we shed light on the post-transcriptional regulation of gene expression in differentiated and undifferentiated @entity2 , revealing a potential role of miRNAs in modulation of @entity0 -host interaction molecules, particularly @entity5 molecules and immune system mediators, which could stimulate crosstalk between @entity0 and the immune system to generate a more @entity1 . We propose a novel putative miRNA:mRNA network that could lead to a new path toward functional studies.

title: Integrated Analysis of XXXX Public Datasets Reveals Role of Post-Transcriptional Regulation on Tumor Progression by Targeting of Immune System Mediators.

answer: @entity2


abstract: OBJECTIVE: To determine the influence of the dose of collagen given nasally on the induction of specific mucosal tolerance in collagen-induced @entity6 . METHODS: The severity of clinical @entity6 induced in DBA/1 @entity0 was studied after the nasal administration (before disease induction) of 1 of 4 doses (across a 2-log range) of @entity5 type II collagen (CII). Parameters of immunity included lymphocyte proliferation and cytokine production in vitro in response to antigen stimulation, and the production of anticollagen IgG antibody subclasses. RESULTS: The 3 highest doses (20, 80, and 320 microg) ameliorated disease severity, whereas the lowest dose (5 microg) aggravated disease. These findings correlated well with antigen-specific T cell proliferation and cytokine and antibody production. T cell proliferation was suppressed by the higher doses of CII, whereas the low dose enhanced T cell proliferation, indicating it primed the T cells. Suppression of T cell proliferation could be overcome by the addition of exogenous @entity8 ( @entity8 ) to these cultures. Decreased T cell proliferation was associated with suppression of both @entity7 ( @entity2 [ @entity2 ]) and @entity3 ( @entity1 ) cytokines and all the subclasses of anticollagen IgG in @entity0 receiving 20, 80, or 320 microg of collagen. Overall, the highest dose of collagen (320 microg) was less effective at suppressing the immune response and disease than the 20-microg or 80-microg doses. There was an increased production of antibodies of all IgG isotypes, and of the @entity7 -associated cytokines @entity2 and @entity8 , in animals that had received the lowest dose of 5 microg collagen nasally. CONCLUSION: Nasal administration of antigens is effective in inducing tolerance and reducing disease severity, but the effects are dose dependent. Low doses can prime the immune system and aggravate disease; high doses may not suppress disease. Suppression of the immune response, which correlates with @entity4 , is not obviously associated with a type I to type II T cell switch, but rather with an overall suppression of both forms of T cell response, with a potential role for anergy of T cells in this process.

title: Importance of dose of type II collagen in suppression of collagen-induced XXXX by nasal tolerance.

answer: @entity6


abstract: @entity7 ( @entity9 ) is the most potent endogenous ligand of brain cannabinoid @entity8 receptors and is synthesized on demand from 2-arachidonate-containing @entity5 by the action of @entity4 lipase in response to increased intracellular @entity2 . Several studies indicate that the endocannabinoid (eCB) system is involved in the mechanism of reward and that diverse drugs of abuse increase brain eCB levels. In addition, eCB are self-administered (SA) by squirrel monkeys, and @entity6 increases nucleus accumbens (NAc) shell @entity3 (DA) in @entity0 . To date, there is no evidence on the reinforcing effects of @entity9 and its effects on DA transmission in rodents. In order to fill this gap, we studied intravenous @entity9 SA and monitored the effect of @entity9 on extracellular DA in the NAc shell and core via microdialysis in male @entity0 . @entity0 were implanted with jugular catheters and trained to self-administer @entity9 [25   mg/kg/inf intravenously (iv)] in single daily 1   h sessions for 5   weeks under initial fixed ratio (FR) 1 schedule. The ratio was subsequently increased to FR2. Active nose poking increased from the 6th SA session (acquisition phase) but no significant increase of nose pokes was observed after FR2. When @entity9 was substituted for vehicle (25th SA session, extinction phase), rate responding as well as number of injections slowly decreased. When vehicle was replaced with @entity9 , SA behavior immediately recovered (reacquisition phase). The reinforcing effects of @entity9 in SA behavior were fully blocked by the @entity8 receptor inverse agonist/antagonist @entity1 (1   mg/kg intraperitoneally, 30   min before SA session). In the microdialysis studies, we observed that @entity9 (0.1-1.0   mg/kg iv) preferentially stimulates NAc shell as compared to the NAc core. NAc shell DA increased by about 25% over basal value at the highest doses tested (0.5 and 1.0   mg/kg iv). The results obtained suggest that the eCB system, via @entity9 , plays an important role in reward.

title: Endocannabinoid @entity7 Self-Administration by XXXX and Stimulation of in vivo @entity3 Transmission in the Nucleus Accumbens Shell.

answer: @entity0


abstract: OBJECTIVES: @entity5 could affect the rate and quality of wound healing in skin. We aimed to investigate the effects of ovariectomy on skin flap viability and @entity6 ( @entity6 ) levels in a @entity2 model. BACKGROUND: Estrogens have many important beneficial and protective roles in skin that they improve collagen content and quality, maintain skin thickness and enhance vascularization. It has been shown that @entity5 supplementation accelerates cutaneous wound healing in elderly @entity0 . METHODS: Forty-eight cycling female @entity2 albino @entity2 were randomly divided into three groups (n = 16); ovariectomy (Group 1), sham (Group 2), and control (Group 3). @entity2 were subjected to bilateral ovariectomy in the Group 1, and only laparotomy in the Group 2. Twenty-one days later in the Group 1 and 2, a dorsal caudally based skin flap elevation was done. In the Group 3, the @entity2 had a dorsal skin flap without any surgical intervention. Ten days later, the flaps were harvested for histopathologic examination and biochemical analyses. RESULTS: The @entity2 in the Group 1 had significantly larger @entity3 area and lower flap viability than in the Group 2 and 3 (p<0.05). Histopathologic examination showed that @entity3 flap regions contained @entity4 with an abundant neutrophil infiltration, and severe @entity1 in the Group 1. The @entity6 activity in the distal of skin flaps was significantly higher in the Group 1 compared to the Group 2 and 3 (p<0.05). CONCLUSION: This study shows that ovariectomy has deleterious effects on skin flap viability in a @entity2 model (Tab. 1, Fig. 6, Ref. 44). KEYWORDS: ovariectomy, skin flap viability, @entity6 , @entity2 .

title: The effect of ovariectomy on the skin flap viability and XXXX levels.

answer: @entity6


abstract: Total @entity2 (TC) directly correlates with overweight/ @entity1 , but it remains unclear if this association varies by race and ethnicity. We assessed the association as well as the racial/ethnic heterogeneity in this relationship. Data on 63,863 @entity0 were assessed using electronic medical records between 2010 and 2011. A cross-sectional design was utilized with log-binomial regression model and chi-squared statistic to examine the data. Overall, abnormal total @entity2 (ATC) was 7.5% (4812). Significant racial variability in ATC was observed: Black/African American (AA) (7.4%), White (7.0%), Asian (5.1%) and some other race (SOR) @entity0 (11.3%),      (5) = 141.5, p < 0.0001. Black/AA (34.7%) and SOR @entity0 (41.2%) were predominantly overweight/ @entity1 , unlike the Asian @entity0 , (25.8%),      (5) = 324.6, p < 0.0001. The BMI percentile was highest among SOR (69.0    28.6) and Black/AA @entity0 (65.2    29.1), but lowest among Asian @entity0 (55.7    31.5). A significant racial variability was also observed in weight, with the highest mean among Black/AA @entity0 (36.8kg    23.0) and the lowest among Asian @entity0 (28.7kg    16.8), f = 7.2, p < 0.001. Relative to normal TC, @entity0 with ATC were 2.6 times as likely to have abnormal BMI, relative risk (RR) =2.60, 99% CI, 2.54-2.68). Compared to non-Hispanic (RR = 2.62, 99% CI, 2.54-2.69), the risk was lower among Hispanics (RR = 2.34, 99%, 2.21-2.48). Among @entity0 with ATC, risk for abnormal BMI was highest among Asians, adjusted RR = 2.91, 99% CI, 2.34-3.62), intermediate among AA ( @entity3 .68, 99% CI, 2.59-2.77), but lowest among Whites ( @entity3 .40, 99% CI, 2.39-2.64), and SOR ( @entity3 .33, 99% CI, 2.19-2.50). In a large sample of @entity0 , total @entity2 directly correlates with BMI, with an observed racial and ethnic heterogeneity.

title: Racial and Ethnic Heterogeneity in the Association Between Total XXXX and Pediatric Obesity.

answer: @entity2


abstract: PURPOSE: A @entity1 's risk of developing @entity0 ( @entity0 ) is increased if she has a personal history (PH) or @entity3 ( @entity3 ) of the disease. We compared the impact of the two risk factors PH and @entity3 on @entity2 detection and @entity2 size at diagnosis in a cohort of @entity0 @entity1 . METHODS: The study cohort comprised 1,037 invasive @entity0 @entity1 ( <=70  years at diagnosis). From these, 92 @entity1 (8.5  %) had a positive PH and 151 @entity1 (13.7  %) had a positive first-degree @entity3 . RESULTS: Compared to the @entity2 of @entity1 without PH or @entity3 , the lesions of @entity1 who had a positive PH or a positive @entity3 were more often found by radiologic breast examinations (RBE) (PH: 49.4  %, @entity3 : 43.4  %, no PH/ @entity3 : 26.2  %; both comparisons p  <  0.001). In @entity1 with a positive @entity3 , the @entity2 were slightly less often found by RBE as in @entity1 with a positive PH (p  =  0.468). @entity1 with a positive PH or @entity3 had smaller @entity2 compared with those without such a history (PH: 19.7  mm, @entity3 : 19.6  mm, no PH/ @entity3 : 26.7  mm; p  =  0.015/p  <  0.001). The @entity2 sizes of @entity1 with a positive PH were almost identical to those of @entity1 with a positive @entity3 (p  =  0.999). CONCLUSIONS: In @entity1 with a positive @entity3 or PH of @entity0 , the increased awareness of @entity0 risk led to the detection of smaller @entity2 compared to @entity1 who have not had this experience. However, comparison of the two risk factors showed that they had a similar impact on the RBE detection rate of @entity0 lesions and that the @entity2 sizes were nearly identical.

title: Personal or first-degree family @entity0 history: which has higher impact on XXXX detection and @entity2 size in @entity0 .

answer: @entity2


abstract: OBJECTIVE: To develop and evaluate a Bayesian network to identify @entity0 eligible for an @entity1 -care guideline using only data available electronically at the time of @entity0 triage. POPULATION: Consecutive @entity0 2-18 years old who presented to a pediatric emergency department during a 2-month period. METHODS: A network was developed and evaluated using clinical data from @entity0 visits. An independent reference standard for @entity1 guideline eligibility was established and verified for each @entity0 through chart review. Outcome measures were area under the receiver operating characteristic curve, sensitivity, specificity, predictive values, and likelihood ratios. RESULTS: We enrolled 3,023 @entity0 visits, including 385 who were eligible for guideline-based care. Area under the receiver operating curve for the network was 0.959 (95% CI = 0.933 - 0.977). At a fixed 90% sensitivity, specificity was 88.3%, positive predictive value was 44.7% and negative predictive value was 98.8%. The positive likelihood ratio was 7.69 and the negative likelihood ratio was 0.11. CONCLUSION: The Bayesian network was able to detect @entity0 eligible for an @entity1 guideline with high accuracy suggesting that this technique could be used to automatically initiate guideline use for eligible @entity0 .

title: Detecting XXXX exacerbations in a pediatric emergency department using a Bayesian network.

answer: @entity1


abstract: INTRODUCTION: Percutaneous cholecystostomy tube (PCT) placement is considered a safe alternative to cholecystectomy for the treatment of @entity5 ( @entity5 ), but data regarding long-term outcomes following PCT are limited. METHODS: We retrospectively reviewed our institutional experience of @entity0 undergoing PCT for @entity5 between 1997 and 2015. Recurrent biliary events were defined as @entity4 , @entity1 , or @entity3 . RESULTS: PCT was placed for 288 @entity0 with @entity5 . Mean age and age-adjusted Charlson comorbidity index were 72        15  years and 5.3        2.4, respectively. Following PCT placement, 91% of @entity0 successfully resolved their episode of @entity5 . @entity2 occurred in 132 @entity0 (46%), with 80 @entity0 (28%) requiring re-intervention, while 7% developed procedure-related complications. Interval cholecystectomy reduced the risk of recurrent biliary events to 7% from 21% (p   =   0.002). Cholecystectomy was completed laparoscopically in 45% of @entity0 receiving an interval operation vs. 22% of those undergoing urgent surgery for PCT failure or recurrent biliary event (p   =   0.03). CONCLUSIONS: PCT placement is a highly successful treatment for @entity5 and is associated with low complication rate, but high rate of @entity2 requiring frequent re-intervention. Interval cholecystectomy is associated with a decreased likelihood of recurrent biliary events and increased likelihood of successful laparoscopic completion.

title: Long-Term Outcomes Following Percutaneous Cholecystostomy Tube Placement for Treatment of Acute XXXX .

answer: @entity4


abstract: OBJECTIVE: @entity0 with @entity3 have abnormal vascular supply to the palate, yet it is unknown whether there are increased postoperative healing problems following palatoplasty. This study investigated the correlation between @entity3 and postoperative palatal @entity1 formation. DESIGN: Retrospective chart review was performed. @entity0 : @entity0 undergoing palatoplasty at @entity0 's Hospital Los Angeles from 1987 to 2000 were evaluated. Ten @entity0 with @entity3 , 92 @entity0 with other syndromes and @entity2 , and 458 nonsyndromic @entity0 with isolated @entity2 were studied. INTERVENTIONS: All @entity0 were treated with a one-stage, double-reversing Z-plasty @entity2 repair. MAIN OUTCOME MEASURES: Outcome measures included intraoperative observations of surgical anatomy and postoperative clinic follow-up of @entity1 formation. Palatal @entity1 rates between @entity0 with @entity3 , other syndromes, and no syndrome were compared with chi-square analysis. RESULTS: @entity0 with @entity3 had significantly greater palatal @entity1 rates (50%) than @entity0 with other syndromes (8.7%) or no syndrome (4.1%). @entity3 @entity0 demonstrated large palatal @entity1 and poor flap vascularity. CONCLUSIONS: @entity0 with @entity3 and @entity2 have significantly higher palatal @entity1 risk than other @entity0 with @entity2 when double-reversing Z-plasty palate repair is performed. Our findings suggest that @entity0 with @entity3 and @entity2 may have poor vascularity to @entity2 created during palatoplasty. Furthermore, we recommend that surgeons performing palatoplasty minimize the dissection of mucoperiosteal flaps around the greater palatine arterial pedicle and utilize closure techniques creating the least vascular disruption of palatal tissue.

title: Increased @entity1 risk following palatoplasty in XXXX .

answer: @entity3


abstract: OBJECTIVE: To investigate the efficacy of detachable balloon for @entity5 in @entity0 with @entity2 and @entity6 . METHODS: Eight @entity0 with @entity2 received splenic artery trunk disconnection using detachable balloons under the guidance of digital subtraction angiography. The diameter and blood flow of the portal vein, the superior mesenteric vein, the @entity1 were measured by color Doppler ultrasound. Markers of liver function and @entity4 , and routine blood parameters were assessed. Gastroscopy was used to evaluate to the degree of @entity7 . All complications experienced during the perioperative period were recorded. RESULTS: The portal vein diameter decreased from 1.55+/-0.38 cm to 1.55+/-0.38 cm, and the splenic artery diameter decreased from 1.45+/-0.10 cm to 1.41+/-0.09 cm (P less than 0.05). The portal vein blood flow was reduced from 971.52+/-174.77 ml/min to 785.86+/-100.17 ml/min, and the splenic vein blood flow decreased from 938.01+/-208.86 ml/min to 644.02+/-188.15 ml/min, while the hepatic artery blood flow increased from 261.25+/-65.47 ml/min to 449.32+/-84.05 ml/min (P less than 0.05). The symptoms of splenism were improved effectively, with platelet counts rising from 37.75+/-10.61*109/L to 138.63+/-28.22*109/L after the procedure (P less than 0.05). There were no episodes of severe complications or @entity3 in the perioperative period, and all @entity0 showed remarkable improvement in markers of liver function and coagulation function, and improvement of esophagogastric varices. CONCLUSIONS: The interventional disconnection technique of the splenic artery trunk using detachable balloon for the treatment of portal @entity2 and @entity6 is safe and effective.

title: [Efficacy of XXXX with detachable balloon for portal @entity2 and @entity6 ].

answer: @entity5


abstract: The optimum therapy for @entity0 with relapsed or @entity11 ( @entity11 ) not qualifying for @entity8 -based and/or high-dose chemotherapy is not known. We conducted a prospective phase II study evaluating a regimen consisting of @entity1 (1 g/m2, days 1 and 8), @entity9 (30 mg/m2, days 1 and 8) and @entity4 (100 mg/day, days 1-8) (GVP) given every 21 days. Fifteen @entity0 with a median age of 68 years and a median of three previous therapies were enrolled. Diagnoses included B lymphoblastic (n=1), diffuse large B cell (n=10), anaplastic large T cell (n=2) and peripheral T-cell @entity11 (n=2). The median international prognostic index score was 3 (six @entity0 with a score of 4 or 5). Five @entity0 achieved a complete remission and three @entity0 a partial remission. The median overall survival was 13.8 months, and the median time to next treatment was 4.4 months. @entity2 of World Health Organisation grades 3/4 were @entity10 in 58%, @entity7 in 33% and @entity6 in 17% of all courses. Three @entity0 had grade 3 @entity5 . There was no treatment-related mortality. GVP shows substantial activity in poor prognosis relapsed or @entity3 and is generally well tolerated, but haematological @entity2 is dose limiting.

title: @entity1 , @entity9 and XXXX for refractory or relapsed @entity3 , results of a phase II single center study.

answer: @entity4


abstract: AIMS: @entity0 with type 1 @entity1 and @entity5 with simultaneous @entity3 (KA) were recruited 9-12 years post transplantation. We investigated differences between these groups with regard to inflammatory parameters and long-term structural changes in kidneys. METHODS: Blood samples were analyzed by ELISA and multiplex for chemokines, cytokines, growth factors, cell adhesion molecules and matrix metalloproteinases. Kidney graft biopsies were analyzed by electron microscopy for glomerular basement membrane thickness. Heparan- and chondroitin @entity6 @entity8 structures were determined by size exclusion chromatography mass-spectrometry. RESULTS: The SPK and the KA group had average glycated hemoglobin A1c (HbA1c) of 5.8% (40mmol/mol) and 8.6% (70mmol/mol) respectively. SPK recipients also had 16.2% lower body mass index (BMI) and 46.4% lower @entity4 levels compared with KA recipients, compatible with an improved metabolic profile in the SPK group. Plasminogen activator inhibitor (PAI-1), C-reactive protein (CRP) and vascular endothelial growth factor ( @entity2 ) were lower in the SPK group. In kidney graft biopsies of the KA- @entity0 an 81.2% increase in average glomerular basement membrane thickness was observed, accompanied by alterations in heparan @entity6 proteoglycan structure. In addition to a decrease in 6-O-sulfated disaccharides, an increase in non-N-sulfated @entity9 with a corresponding slight decrease in N-sulfation was found in kidney biopsies from @entity7 @entity0 . CONCLUSIONS: @entity0 with @entity5 subjected to KA transplantation showed impaired inflammatory profile, increased thickness of basement membranes and distinct changes in heparan @entity6 structures compared with SPK recipients.

title: Effects of restoring normoglycemia in type 1 XXXX on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation.

answer: @entity1


abstract: STATEMENT OF PROBLEM: @entity5 ( @entity5 ) and ethmoid @entity3 ( @entity3 ) are rare sinonasal malignancies that often involve the skull base. Standard surgical treatment is craniofacial resection (CFR), which allows for efficient removal but entails significant morbidity and mortality. Because expanded endoscopy nasal approaches are newly developed, we aimed to describe the procedure in @entity0 with @entity5 and @entity3 and compare it with CFR in terms of efficiency and morbidity. METHODS: This work reports on a retrospective series of 16 @entity0 with @entity3 and @entity5 treated endoscopically with anterior skull-base resection in a single institution over 9 years. Invasion of the frontal sinus, massive extension to the cerebral parenchyma, spread of the @entity1 above the orbits or lysis of anterior facial skeleton were contraindications for endoscopy resection. RESULTS: Of the 16 @entity0 , 11 had @entity3 and 5 @entity5 . In total, 37.5% (6) exhibited skull-base invasion. All @entity0 had postoperative radiotherapy. In the early postoperative period, one @entity0 experienced delayed @entity2 due to a minor subdural @entity4 . Two delayed complications were observed: one encephalocele related to inappropriate postoperative care, which required revision surgery, and one extended radionecrosis. Five-year disease-free survival was 83% and 5-year recurrence-free survival 58%. Local control rate was 91% for @entity3 and 100% for @entity5 . CONCLUSIONS: With low perioperative morbidity and efficient local control, ethmoidectomy combined with anterior skull-base resection is a promising approach for managing selected cases of @entity3 and @entity5 . These findings need further investigation with prolonged follow-up.

title: Endoscopy skull-base resection for ethmoid XXXX .

answer: @entity3


abstract: It is said that the prognosis is generally unfavorable in @entity0 with hypertensive @entity7 showed extravasation on angiogram. Recently, we experienced a case whose prognosis was eventful after the removal of @entity6 . So we reported this case and discussed between @entity2 and @entity7 accompanied with extravasation on angiogram in this paper. A 59-year-old male was transferred to our emergency center because of right @entity4 and mild clouding of consciousness at around nine in the evening on December 12, 1983. At the time of admission, his neurological state was classified into grade II, exhibiting the right putamenal @entity1 and pyramidal destruction type of @entity6 by CT scan with 58 ml of @entity6 volume. The right carotid angiography was immediately performed and confirmed the @entity6 being of lateral type. At that time, extravasation proximal to the lateral lenticulostriate artery was noted. Repeated CT scan revealed the enlarged @entity6 (105 ml) accompanying with @entity1 . At the completion of these examinations, the neurological grade was III. The @entity6 was surgically removed after 4 hours following the onset of @entity7 . His postoperative course was very favorable. Although acute @entity5 appeared later on, it was cured by ventricular drainage. The @entity0 become possible to walk with a helper by 1 month after operation. CT scan obtained 1 month after operation revealed a remarkable @entity3 , which was probably derived from chronic @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case favorably progressed after operation for hypertensive @entity7 showed extravasation on angiogram occurred in chronic XXXX ].

answer: @entity2


abstract: OBJECTIVES: Pelvic organ prolapse (POP) is an important problem for @entity0 with multifactorial etiology. This study aims to determine the role of @entity4 ( @entity4 ) and @entity1 ( @entity1 ) in POP. STUDY DESIGN: The study included 586 @entity0 admitted to Bulent Ecevit University Hospital between September 2013 and April 2015 for hysterectomy, comprising 186 @entity0 with POP and 400 @entity0 without. The demographic characteristics, age, body mass index (BMI), obstetrical history, type of delivery, associated medical diseases, and benign gynecological diseases were recorded. @entity4 , @entity1 , or both together were particularly considered as coexisting medical diseases. RESULTS: Median gravida, parity, and live birth numbers were significantly higher in POP @entity0 (4 vs. 3, 3 vs. 2, and 3 vs. 2 respectively, p<0.001). POP @entity0 were more @entity2 than POP-absent @entity0 (p<0.001). Vaginal history of birth increased POP frequency to 25.8% with statistical significance (p<0.001). There was no significant difference between groups regarding coexisting @entity7 , @entity5 , @entity3 , @entity6 (p>0.05). There was a significant difference between groups regarding comorbid diseases (p<0.001). Logistic regression analysis for risk factors of POP revealed age, BMI, vaginal parturition, and co-morbidity with @entity4 + @entity1 together significantly increased POP risk (p<0.05). @entity4 + @entity1 together significantly increased risks with OR of 1.9 (1.1-3.16). CONCLUSIONS: In addition to multiple factors increasing POP risk, comorbidities as @entity4 + @entity1 together should be considered as risk factors. @entity0 with these comorbidities should be encouraged to change their lifestyles to prevent POP.

title: Are @entity4 and XXXX risk factors for pelvic organ prolapse?

answer: @entity1


abstract: UNASSIGNED: @entity1 ( @entity1 ) is a type of head and @entity0 with a high mortality rate. @entity2 ( @entity2 ) is the pre-cancerous lesion of @entity1 , whose molecular mechanisms in @entity1 tumorigenesis remain largely unclear. Activation of the Wnt/b-catenin signaling pathway plays an important role in oral mucous carcinogenesis, although rare mutations of Wnt signaling molecules are found in @entity1 , suggesting an epigenetic mechanism mediating aberrant Wnt/b  -catenin signaling in @entity1 . @entity4 ( @entity4 ) is an Wnt antagonist, and its downregulation and methylation have been reported in a number of @entity0 . However, the expression and methylation of @entity4 in the development of @entity2 have yet to be reported. In the present study, we investigated the @entity4 expression level by immuno-histochemical staining and semi  -quantitative RT-PCR in normal oral, @entity2 and @entity1 tissues, as well as the methylation status by methylation-specific PCR and @entity3 genomic sequencing. The results showed that @entity4 was readily expressed in normal oral mucous tissues, but decreased gradually in @entity2 early, moderately advanced and advanced tissues, and was less expressed in @entity1 tissues. Moreover, @entity4 was able to translocate from the nuclear to cytoplasm in @entity2 and @entity1 tissues. Furthermore, @entity4 was frequently methylated in @entity1 cases with betel quid chewing habit, but not in normal oral mucous and different stages of @entity2 tissues, suggesting @entity4 methylation is tumor-specific in the development of @entity2 . Thus, the results demonstrated that @entity4 is frequently downregulated or silenced by promoter methylation in the carcinogenesis of @entity2 , which serves as a potential epigenetic biomarker for the early detection of @entity1 .

title: Expression and promoter methylation of XXXX in the development of @entity2 .

answer: @entity4


abstract: BACKGROUND AND PURPOSE: @entity1 is associated with an increased risk of @entity2 . Our purpose was to assess whether there is an increased risk during @entity3 coiling and clipping. MATERIALS AND METHODS: Data were obtained from the National Inpatient Sample (2000-2011). All subjects had an unruptured @entity3 clipped or coiled and were divided into @entity8 (n = 189) and control (n = 3555) groups. Primary end points included in-hospital mortality, length of stay, and total hospital charges. Secondary end points included the International Classification of Diseases, Ninth Revision codes for @entity4 or @entity6 ; @entity5 ; @entity6 ; and carotid and @entity7 . RESULTS: There was a significantly greater incidence of @entity4 or @entity6 , @entity6 , and carotid artery dissection in the @entity0 with @entity1 compared with the control group after endovascular coiling. There was also a significantly greater incidence of @entity4 or @entity6 in the @entity8 group after surgical clipping. However, the hospital stay was not longer in the @entity8 group, and the total hospital charges were not higher. Additional analysis within the @entity8 group revealed a significantly shorter length of stay but similar in-hospital costs when subjects underwent coiling versus clipping. CONCLUSIONS: @entity0 with @entity1 face an increased risk during @entity2 treatment, whether by coiling or clipping. This risk, however, does not translate into longer hospital stays or increased hospital costs. Despite the additional catheterization-related risks of dissection and embolization, coiling results in shorter hospital stays and similar mortality compared with clipping.

title: @entity1 and XXXX : Is There an Increased Risk of Treatment?

answer: @entity2


abstract: While the impact of exogenous glucocorticoids on the fetal cardiovascular system has been well defined, relatively few studies have characterised the role of endogenous fetal glucocorticoids in the regulation of arterial blood pressure (BP) during late gestation. We have therefore infused @entity2 , an inhibitor of @entity0 biosynthesis, into fetal @entity1 from 125 days gestation (when fetal @entity0 concentrations are low) and from 137 days gestation (when fetal @entity0 concentrations are increasing) and measured fetal plasma @entity0 , @entity3 and ACTH, fetal systolic, diastolic and mean arterial BP, heart rate, and the fetal BP responses to increasing doses of angiotensin II (AII). At 125 days gestation, there was a significant increase in fetal plasma ACTH and @entity3 by 24 h after (+24 h) the start of the @entity2 infusion, and plasma @entity0 concentrations were not different at +24 h when compared with pre-infusion values. Whilst the initial fall in circulating @entity0 concentrations may have been transient, systolic, diastolic and mean arterial BP were ~5-6 mmHg lower (P < 0.05) in @entity2 - than in vehicle-infused fetuses at 24-48 h after the start of the infusion. When @entity2 was infused from 137/138 days gestation, there was a significant decrease in plasma @entity0 concentrations by +6 h, which was followed by an increase back to pre-infusion values. While @entity0 concentrations decreased, there was no change in fetal mean arterial BP during the first 24 h after the start of @entity2 infusion. Mean fetal arterial BP values at 137-139 days gestation were not different in fetuses that had been infused with either vehicle or @entity2 from 125 days gestation or with @entity2 from 137/138 days gestation. At 137-139 days gestation, however, arterial BP responses to increasing doses of AII were significantly blunted in fetuses that had been infused with @entity2 from 125 days gestation, when compared with fetuses that had been infused with @entity2 from 137/138 days gestation or with vehicle from 125 days gestation. The dissociation of the gestational age increase in arterial BP and the effects of intrafetal AII on fetal arterial BP indicates that increase in fetal BP with gestational age is not entirely a result of an increased vascular responsiveness to endogenous AII. Furthermore there may be a critical window during late gestation when the actions of @entity0 contribute to the development of vascular responsiveness to AII.

title: The effect of intrafetal infusion of XXXX on arterial blood pressure and on the arterial blood pressure response to angiotensin II in the @entity1 fetus during late gestation.

answer: @entity2


abstract: @entity2 ( @entity3 ) is associated with complex clinical situations such as @entity1 in a solitary kidney, bilateral, large or multicentric @entity1 or those associated with @entity7 ( @entity7 ) or pregnancy. Management in these situations may be challenging. Fifteen @entity0 (20 kidneys) were admitted with symptomatic @entity3 over last 10 years. Eleven @entity0 had one or the other complicating factor. Ten @entity0 had a @entity1 of >10 cm, 4 had @entity7 , 5 had @entity1 , 1 @entity0 was pregnant and 1 had a solitary functioning kidney. With the newer imaging modalities correct diagnosis was possible in 12 cases and @entity5 ( @entity5 ) was suspected in 3 cases. @entity6 ( @entity6 ) was done in 3 @entity0 , which successfully controlled @entity4 in all. Nephron-sparing surgery (NSS) was performed in 5 @entity0 . Total nephrectomy was done in 4 cases, in 3 due to suspicion of @entity5 and in 1 due to extensive involvement of the kidney. Three @entity0 with @entity1 were chosen for conservative treatment and none developed recurrence of @entity4 on strict follow-up. In a pregnant @entity0 , @entity4 was successfully controlled with angioembolization. However, 1 @entity0 with a solitary functioning kidney with large-sized @entity1 (20 x 18 cm) underwent NSS. In conclusion, the basis of management of @entity3 is preservation of renal tissue, which can be effectively achieved with @entity6 or NSS. In a solitary functioning kidney, NSS or @entity6 is the ideal treatment, if feasible. The @entity0 in the @entity7 group are usually more complicated and require life-long follow-up after initial management with NSS or @entity6 . Pregnant @entity3 @entity0 can be safely managed with @entity6 . Conservative treatment without any intervention and regular follow-up may be more helpful in some @entity0 with multiple, bilateral extensive @entity1 .

title: Management of XXXX in complex clinical situations.

answer: @entity2