abstract: OBJECTIVE: The efficacy of double-filtration plasmapheresis (DFPP), combined with @entity8 , to treat diffuse proliferative @entity9 ( @entity9 ) was studied. METHODS: Twenty-four @entity0 who were admitted to the hospital and diagnosed with diffuse proliferative @entity9 ( @entity9 Class IV-G(A)) through renal biopsy from 2011 to 2013 were recruited as the study subjects. The @entity0 ' clinical manifestations were @entity5 and/or @entity3 . The pathological features were @entity2 . The @entity0 were divided into two groups: the treatment group and the control group, with 12 @entity0 in each group. The @entity0 in the treatment group were first treated with DFPP combined with @entity8 (0.8-1.0 mg/kg/day); subsequently, they were put on @entity8 therapy only. The @entity0 in the control group were first put on @entity8 pulse therapy (500-1,000 mg) for 3 days; subsequently, they were treated with @entity8 (0.8-1.0 mg/kg/day) combined with @entity4 (1.5 g/day). The @entity0 were observed for 24 months. Levels of hemoglobin, platelet, albumin, serum @entity6 , 24-h urinary protein, serum C3 , antinuclear antibody (ANA), anti-dsDNA, and anti-Smith were measured at 0, 3, 6, 12, and 24 months. Complete remission and recurrence standards were established. The total dosages of @entity8 were calculated. Repeated renal biopsy was performed on several @entity0 . RESULTS: There was no statistical significance in the baseline conditions of the treatment and the control groups. For the treatment group, no plasmapheresis-related complications occurred. The two groups showed no significant difference in complete remission. The @entity0 ' @entity1 and @entity7 resolved, urine volume, serum @entity6 , and albumin levels returned to normal, urine protein decreased in treatment group more rapidly than the @entity0 in the control group. The mean dose of @entity8 received in the treatment group was lower than in the control group. The @entity10 levels in the treatment group were significantly higher than in the control group. The recurrence rate in the treatment group was lower than in the control group. Repeated renal biopsies on several @entity0 in the treatment group indicated that their pathology improved significantly, changing from @entity9 (IV) to @entity9 (II-III). CONCLUSIONS: Appropriate application of DFPP combined with glucocorticoid therapy could accelerate the remission of diffuse proliferative @entity9 , reduce overall glucocorticoid dosage, prevent recurrence, and maintain C3 level in a higher level. J. Clin. Apheresis 31:375-380, 2016.    2015 Wiley Periodicals, Inc.

title: Therapeutic effect of double-filtration plasmapheresis combined with @entity8 to treat diffuse proliferative XXXX .

answer: @entity9


abstract: OBJECTIVES: Paratesticular @entity4 accounts for 7-10% of @entity1 and is the 3(rd) most common after RMS of the prostate and bladder. Though most (60%-80%) @entity0 with paratesticular rhabdomysarcoma present with localized disease, assessment of @entity3 is vital. The treatment of @entity4 has evolved over several decades; the current standard of care is multimodal treatment including surgery, chemotherapy, and radiation. We give insight into the evolution of treatment, present the oncologic outcomes of seminal studies, and summarize the current recommendations for the management of these @entity0 . METHODS: A comprehensive search of the literature on the electronic databases PubMed was conducted for management of @entity4 . Case reports were excluded, clinical trials from all the oncologic society were reviewed and relevant articles are included in the review. RESULTS: The treatment regimen is based on following principles: (1) local control of the primary site with radical orchiectomy and (2) assessment of local control and distant sites. Further treatment is directed according to disease stage, histology, and age of the @entity0 . The goal of treatment is to achieve cure or maximum @entity1 control while minimizing @entity2 . CONCLUSIONS: With the changing landscape in the management of paratesticular rhabomyosarcoma, significant improvement is evident in the oncologic outcomes. Further advance in genomic testing would lead us to tailor treatment based on individual risk factors and minimize long-term side effects.

title: Current management of XXXX .

answer: @entity4


abstract: 1. The biliproteins C-phycocyanin and @entity3 were purified from the blue-green alga @entity1 by @entity0 fractionation and gel filtration. 2. An assay procedure that enabled the proportion of the two pigments, present as a mixture, to be determined was devised by using the data provided by spectrophotometric analysis of the purified biliproteins. 3. The degree of association and relative proportions of the two pigments were analysed by the application of this procedure to the components separated by thin-layer gel filtration. 4. The C-phycocyanin/ @entity3 ratio remained essentially constant in algal extracts prepared at various stages throughout the growth cycle or after growth under conditions of reduced illumination. 5. The behaviour of the C-phycocyanin aggregate species from @entity2 suggested that they were of appreciably lower molecular weight than those observed in extracts of @entity1 .

title: C-phycocyanin and XXXX in two species of blue-green algae.

answer: @entity3


abstract: OBJECTIVE: To investigate the prevalence and clinical significance of carotid artery @entity5 ( @entity5 ) in @entity0 with @entity10 ( @entity10 ). METHODS: 28 @entity0 with primary @entity10 with at least a five year follow up, and 28 healthy subjects, matched by age and sex, were included in the study. Colour Doppler with high resolution B mode carotid ultrasonography and spectral analysis were performed in @entity0 and controls. Information on cardiovascular risk factors and the clinical course were collected. RESULTS: The mean (SD) age of @entity0 and controls (12 male, 16 female in each group) was 40 (8.5) years; the mean (SD) disease duration 7.7 (3) years. Carotid artery @entity5 was found in 23/28 @entity0 (2.6 (1.14) mm) and 7/28 controls (1.2 (0.44)) (p=0.0001). A decrease in the lumen diameter was also found in 11/28 @entity0 with primary @entity10 without @entity11 , and 2/28 controls (p=0.004). Hyperlipidaemia, @entity1 , smoking, @entity2 , and @entity4 were not associated with carotid artery @entity5 . @entity0 with carotid artery @entity5 had @entity6 more often than @entity0 without: 9/23 v 0/5 (p<0.009). These @entity0 had @entity3 (seven @entity0 ), @entity7 (one), and @entity8 (one). Subjects with @entity5 had a threefold higher risk for @entity3 than those without @entity5 (95% CI 0.78 to 14.3). CONCLUSIONS: @entity0 with primary @entity10 have a high prevalence of carotid artery @entity5 and a decreased lumen diameter. @entity5 in primary @entity10 may be associated with @entity3 . @entity0 with primary @entity10 with @entity5 must be considered as carriers of @entity9 .

title: Increased carotid artery @entity5 may be associated with XXXX in @entity10 .

answer: @entity3


abstract: Autologous peripheral blood stem cell transplantation (auto-PBSCT) after high dose chemotherapy is usually offered to @entity0 @entity1 carrying a high risk of relapse or having chemosensitive metastatic disease. Whether progression free and overall survival of such @entity1 is improved after auto-PBSCT compared to conventional chemotherapy is a matter of debate. Currently available results of randomised trials could not uniformly prove or disprove auto-PBSCT being advantageous. Yet such studies have not employed any manipulation of the stem cell graft or any post-transplant immunomodulation exploiting the unique immunological environment for @entity2 eradication which exists only after auto-PBSCT. Preliminary data have discussed the ex vivo and in vivo generation of cytotoxic effector cells employing @entity4 and/or @entity5 /gamma in the auto-PBSCT setting. Other cytokines such as IL-12, @entity6 and prolactin have likewise been considered. Several anticancer vaccine protocols after auto-PBSCT are ongoing using monovalent vaccines or anti-idiotypic antibodies. Polyvalent anticancer vaccines, cytokine secreting @entity2 cells, @entity2 pulsed or hybridised dendritic cells (DC) enhanced with cytokines are studied. Monoclonal antibodies (mAb) could assist: unlabelled for pretransplant exvivo purging, post-transplant for enhancing @entity3 ( @entity3 ) or radioimmunoconjugated as an additive cytotoxic part of the conditioning regimen. Autologous graft versus host induction and allogeneic stem cell transplantation (probably with non-myeloablative conditioning followed by donor lymphocyte infusions) are other approaches. Evaluation of successful combinations, optimal dosages and appropriate timing schedules is the subject of future investigations. Since @entity0 @entity1 belong to countless subgroups, a large number of protocols need to be addressed in order to avoid over treatment and prevent relapse.

title: Blood stem cell transplantation for XXXX : new approaches using pre- peri- post-transplant immunotherapy.

answer: @entity0


abstract: We have analyzed 61 German @entity0 families for @entity4 mutations using single-strand conformation polymorphism analysis (SSCP) followed by sequencing. Forty-seven of the families had at least three cases (at least two under 60 years) and 14 families had only two cases of @entity3 (at least one under 50 years). Twenty-eight families were @entity3 were @entity0 families. Eighteen mutations in @entity4 were detected in 11/28 @entity3 families and 7/33 @entity0 families and none in the families with only two cases. We identified 17 truncation mutations (8 frameshift, 7 nonsense and 2 splice variants) and one missense mutation. Seven of these are novel and two, the @entity5 and @entity6 mutations, occurred in two apparently unrelated families. The genotype of the two families with the @entity5 mutation is compatible with the rare haplotype segregating with the @entity5 mutation in different populations, further supporting its European origin. One unclassified missense alteration, @entity7 , was found in one family but did not segregate with the disease, suggesting that it is more likely a polymorphism. We also report and discuss the sequence of several new unclassified single- @entity2 changes first identified by SSCP. Of the 18 mutations, 13 occurred in the 3' third of the gene (end of exon 11-24) and @entity1 were found in eight of these families.

title: A high proportion of mutations in the @entity4 gene in German XXXX families with clustering of mutations in the 3' third of the gene.

answer: @entity3


abstract: UNASSIGNED: @entity0 are characterized by the abnormal accumulation of protein aggregates and the progressive @entity1 . Our @entity3 studies demonstrate that middle-aged @entity2 ( @entity2 , ~4-weeks) exhibit a marked accumulation of @entity4 that is commensurate with the decline of the autophagy pathway. However, enhancing autophagy via neuronal over-expression of @entity5 ( @entity5 -OE) reduces the age-dependent accumulation of aggregates. Here we assess basal locomotor activity profiles for single- and group-housed male and female @entity2 flies and observed that only modest behavioral changes occurred by 4-weeks of age, with the noted exception of group-housed male flies. Male flies in same-sex social groups exhibit a progressive increase in nighttime activity. Infrared videos show aged group-housed males (4-weeks) are engaged in extensive bouts of courtship during periods of darkness, which is partly repressed during lighted conditions. Together, these nighttime @entity1 were nearly absent in young @entity2 flies and aged @entity5 -OE flies. Previous studies have indicated a regulatory role for olfaction in male courtship partner choice. Coincidently, the mRNA expression profiles of several olfactory genes decline with age in @entity2 flies; however, they are maintained in age-matched @entity5 -OE flies. Together, these results suggest that middle-aged male flies develop impairments in olfaction, which could contribute to the dysregulation of @entity1 during dark time periods. Combined, our results demonstrate that as @entity3 age, they develop early behavior defects that are coordinate with protein aggregate accumulation in the nervous system. In addition, the nighttime activity behavior is preserved when neuronal autophagy is maintained ( @entity5 -OE flies). Thus, environmental or genetic factors that modify autophagic capacity could have a positive impact on neuronal aging and complex behaviors.

title: Aging and Autophagic Function Influences the Progressive Decline of Adult XXXX Behaviors.

answer: @entity3


abstract: OBJECTIVE: To investigate whether an association exists between a history of fertility treatments and future risk of female @entity1 . STUDY DESIGN: A population-based study compared the incidence of long-term female @entity1 in a cohort of @entity0 with and without a history of fertility treatments including @entity4 ( @entity4 ) and ovulation induction (OI). Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12  years. Excluded from the study were @entity0 with known genetic predisposition for @entity1 or known @entity1 prior to the index pregnancy. @entity1 were divided into specific types including ovarian, uterine, breast and cervix. Kaplan-Meier survival curve was used to estimate cumulative incidence of @entity1 . Cox proportional hazard models were used to estimate the adjusted hazard ratios (HRs) for female malignancy. RESULTS: During the study period, 106,031 @entity0 met the inclusion criteria; 4.1  % (n  =  4363) occurred in @entity0 following fertility treatments. During the follow-up period, @entity0 with a history of @entity4 treatments had a significantly increased risk of being diagnosed with @entity3 as compared to @entity0 after OI and @entity0 with no history of fertility treatments. Cox proportional hazard models were @entity3 separately, controlling for confounders such as maternal age and @entity2 . A history of @entity4 treatment remained independently associated with @entity3 (adjusted HR 3.9; 95  % CI 1.2-12.6; P  =  0.022 and adjusted HR 4.6; 95  % CI 1.4-14.9; P  =  0.011; respectively). CONCLUSION: @entity4 treatments pose a significant risk of subsequent long-term @entity3 .

title: The risk of female XXXX after fertility treatments: a cohort study with 25-year follow-up.

answer: @entity1


abstract: OBJECTIVE: To compare the formation of gap junctions between detrusor smooth muscle cells in situ and the distribution of @entity11 (Cx)40, @entity6 and @entity12 expressions in bladder biopsies from a control group (with @entity2 ) and from @entity0 with urge symptoms, as smooth muscle cells of the @entity0 detrusor muscle communicate via gap junctions and express several @entity11 subtypes, alterations of which may be involved in the causes of lower urinary tract symptoms. MATERIALS AND METHODS: @entity11 expression is prominent in myofibroblast-like cells, supposedly involved in afferent signalling pathways of the bladder. Their strategic position directly beneath the urothelium suggests they are a link between urothelial @entity7 signalling during @entity8 and afferent Adelta-fibre stimulation for co-ordination of bladder tonus and initialization of the micturition reflex. Modification of their coupling characteristics may have profound @entity8 . Bladder tissue probes of @entity0 undergoing cystectomy or transurethral @entity1 resection for @entity2 were used as controls. Tissue samples from @entity0 with severe @entity4 were taken for exclusion diagnostics of @entity9 ( @entity9 ) and @entity3 in situ. The formation of functional syncytia between detrusor smooth muscle cells were examined in dye-coupling experiments by injecting with Lucifer Yellow. The morphology and structure of gap junctions were assessed by transmission electron microscopy and immunogold labelling of @entity6 and @entity12 . The expression of @entity11 subtypes @entity10 , @entity6 and @entity12 was compared by indirect immunofluorescence, and confocal laser scanning microscopy used for semiquantitative analysis. RESULTS: There was dye coupling between smooth muscle cells of the detrusor in situ. Electron microscopy and immunogold labelling showed very small gap junctional plaques. These findings were confirmed by confocal immunofluorescence. Semiquantitative analyses showed significantly higher @entity6 expression in the detrusor muscle, and a tendency to higher @entity12 expression in the suburothelial layer associated with urge symptoms, whereas @entity10 expression was unaffected. CONCLUSIONS: Smooth muscle cells of the @entity0 detrusor muscle are coupled by classical gap junctions, forming limited local functional syncytia. Both @entity6 and @entity12 are expressed at low levels in normal detrusor. Up-regulation of @entity6 in @entity0 with urge @entity5 supports the possibility of functional changes in the syncytial properties of detrusor smooth muscle cells in this condition. In addition, the observed increase of @entity12 in the myofibroblast cell layer supports the idea that alterations in sensory signalling are also involved. Comparison with previous reports implies that the pathophysiology of urgency is distinct from that of the unstable bladder and other forms of @entity5 .

title: Alterations in XXXX expression in the bladder of @entity0 with urge symptoms.

answer: @entity11


abstract: Obesity is a heterogeneous disease and is associated with comorbidities such as @entity2 , @entity4 and @entity1 . Several studies have examined the role of dysfunctional adipose tissue in the pathogenesis of @entity3 , highlighting the contrasting properties and impact of distinct fat compartments, sometimes with contradictory results. Dysfunctional adipose tissue involves enlargement, or @entity7 , of pre-existing fat cells, which is thought to confer increases in cardiometabolic risk, independent of the level of @entity3 per se. In this article, we critically analyze available literature that examined the ability of adipocyte cell size to predict @entity5 in @entity0 . Many studies demonstrate that increased fat cell size is a significant predictor of altered blood lipid profiles and @entity6 -insulin homeostasis independent of @entity8 indices. The contribution of visceral @entity8 to these associations appears to be of particular importance. However, available studies are not unanimous and many fat depot-specific aspects of the relationship between increased fat cell size and cardiometabolic risk or parameters of adipose tissue dysfunction are still unresolved. Methodological factors such as the approach used to express the data may represent significant confounders in these studies. Additional studies should consider the fact that the relationship between fat cell size and common @entity8 indices is non-linear, particularly when reaching the obese range. In conclusion, our analysis demonstrates that fat cell size is a significant predictor of the cardiometabolic alterations related to @entity3 . We propose that adipocyte @entity7 , especially in the visceral fat compartment, may represent a strong marker of limited hyperplasic capacity in subcutaneous adipose tissues, which in turn is associated with the presence of numerous cardiometabolic alterations.

title: Adipocyte size as a determinant of XXXX .

answer: @entity5


abstract: AIM: To assess clinical and contemporary costs associated with elective endovascular repair of intact descending thoracic @entity2 into the mid term follow--up. METHODS: A retrospective review of a prospectively maintained clinical database including 29 consecutive @entity0 from July 2005 to December 2009 treated with elective endovascular repair (TEVAR) or TEVAR and surgical infrarenal repair (hybrid) of intact descending thoracic @entity2 was performed. Mean age was 74.5 years old (   7.1). Primary clinical endpoints include mortality and major morbidity. Additionally a comprehensive economic appraisal of individual in--hospital and follow up costs was executed. Economic endpoints include in--hospital and follow--up costs and @entity0 discharge status. Elective endovascular and open repairs' clinical and economical outcomes in contemporary literature were assessed for comparison according to PRISMA standards. RESULTS: Immediate mortality was 6.9% (1/24 TEVAR and 1/5 hybrid). Three @entity4 were recorded (11%;; 2 TEVAR, 1 hybrid). @entity1 rates were 7.4% (1 TEVAR, 1 hybrid) and 3.7% (1 TEVAR) respectively. Routine discharge home was achieved for 85% of @entity0 (95.7% TEVAR, 25% hybrid). Three @entity3 were treated throughout the follow--up (2 TEVAR, 1 hybrid;; mean 30.4 mo,   19.9) rendering an 11% (3/27) reintervention rate. Average immediate cost was    21,976.87 for elective endovascular repair and    33,783.21 for elective endovascular hybrid repair. Additional reintervention and routine follow--up costs augmented immediate costs by 12.4%. CONCLUSIONS: This study supports satisfying immediate clinical outcomes for TEVAR and TEVAR + surgical infrarenal procedures. Although limited by a small population size and difficulties in economic comparisons, this study presents the real world social and economic cost scenario for both elective TEVAR and TEVAR hybrid treatment of DTAA of both the in--hospital and at mid term follow--up periods.

title: Contemporary economic and clinical evaluations of endovascular repair for intact descending thoracic XXXX .

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) @entity0 with @entity4 have a lower quality of life (QoL) and while the impact of @entity4 on QoL in @entity5 @entity0 has been described few data exist on the presence and impact of lower gastrointestinal (LGI) and @entity10 in @entity5 . Our goal was to assess the prevalence of these symptoms in @entity0 with @entity5 and evaluate their impact on QoL. A secondary hypothesis was that the impact of LGI symptoms on QoL is mediated by @entity2 . STUDY: @entity0 with @entity5 (n=175) attending an outpatient @entity9 clinic completed multiple validated questionnaires. Pelvic floor and LGI symptoms included @entity7 ( @entity7 ), @entity3 ( @entity3 ), @entity3 ( @entity3 ), chronic @entity6 , @entity1 , and @entity8 . The Student t tests adjusted for multiple comparisons were used to evaluate group differences at the 0.05 level. RESULTS: Complete data were available for 160 @entity0 . @entity7 was reported by 65, @entity3 by 64, @entity3 by 40, chronic @entity6 by 94, @entity1 by 82, and @entity8 by 35 of @entity5 @entity0 . Overall QoL was reduced in @entity5 @entity0 with @entity7 (0.96 vs. 0.63; P=0.007), @entity3 (0.96 vs. 0.65; P=0.01), @entity3 (1.11 vs. 0.67; P=0.002), and @entity8 (1.01 vs. 0.70; P=0.04). Antidepressant use was reported by 26%. The negative impact on QoL in @entity0 with @entity10 was partially mediated by @entity2 . CONCLUSIONS: @entity0 with @entity5 suffer from an increased prevalence of LGI and @entity10 including @entity7 , @entity3 , @entity1 , @entity6 , and @entity8 and this effect seems to be partially mediated by @entity2 .

title: The Impact of Pelvic Floor and Lower Gastrointestinal Symptoms on Quality of Life in @entity0 With XXXX .

answer: @entity5


abstract: In 50% of the @entity0 presenting with a @entity7 , the cause is cardiac. The incidence of @entity6 with 24% is high in this group. Since most of the @entity5 -induced @entity7 are due to @entity8 ( @entity8 ), a careful diagnostic approach must be used. The possibility of a @entity8 to end in a fibrillation is great, especially in the presence of a @entity2 , which leads to a bad prognosis in such @entity0 . The aim of a careful anamnesis and clinical history is to establish the presence of a @entity2 . A @entity9 , a long QT, an old @entity4 or a @entity3 ( @entity3 ) can be assessed by echocardiography (ECG). Stress testing is useful in evaluating a @entity3 and can possibly lead to a diagnosis when a @entity8 or a @entity10 ( @entity10 ) is induced. ECG is used to assess the cardiac ejection fraction and in the evaluation of a suspected right or left @entity1 . The ambulatory ECG allow a diagnosis only in 2 to 3% of the cases. Nevertheless, the presence of more than 10 PVC/h and/or asymptomatic nonsustained @entity8 is a predictor for @entity6 in syncopy @entity0 . Detection of late potentials has a sensitivity of 50 to 83% and a sensibility of 89 to 91% for the prediction of inducible sustained @entity8 during electrophysiological studies (EPS) in @entity0 with @entity7 . However, the usefulness of this technique is not fully established, since there is no significant difference in survival or recurrence of @entity7 between @entity0 with and without late potentials. The EPS is an invasive technique and therefore used at the end of the investigations. The cardiovascular mortality is low (4%) in @entity0 with a negative EPS. A treatment is mandatory in @entity5 -induced @entity7 even when the cause is a @entity10 . Antiarrhythmic drugs are useful for the treatment of @entity10 . However, radiofrequency ablation of the accessory pathway is preferable, since the success rate is over 90%, and the side effects of chronic ingestion of antiarrhythmic drugs can therefore be avoided. Some @entity8 can be treated successfully with drugs under the control of an EPS, but most of the @entity0 must have the implantation of an @entity2 ( @entity2 ).

title: [ XXXX -induced @entity7 ].

answer: @entity5


abstract: A hyperfractionated radiation therapy (HFX RT) trial (1.2 Gy twice daily, b.i.d.) (HFX) for @entity5 ( @entity5 ) showed that 69.6 Gy resulted in better survival than did lower total doses (Radiation Therapy Oncology Group, RTOG 83-11) and that @entity4 concurrent with irradiation improved local control and survival over RT alone (Radiation Therapy Oncology Group, RTOG 91-06). Concurrent combination chemotherapy and HFX could improve both local and systemic control. In a phase II trial (RTOG 91-06) for inoperable @entity5 , two cycles of PE were used [ @entity4 50 mg/m2 intravenously (i.v.) days 1 and 8, @entity7 50 mg orally (p.o.) b.i.d., 75 mg/day if body surface area (BSA) < 1.7 m2, days 1-14] starting on day 1 of HFX (69.6 Gy) and repeated on day 29. HFX/PE was compared with HFX (69.6 Gy) from an earlier phase II trial (RTOG 83-11). Seventy-six @entity0 treated with HFX/PE and 203 @entity0 who received HFX alone were compared for @entity2 , response, survival, and patterns of failure. The rates of grade 4 nonhematologic @entity2 were similar (3.0% for HFX/PE, 3.0% for HFX), but grade 4 @entity6 occurred only with HFX/PE 56.6%. Three (3.9%) HFX/PE @entity0 had fatal @entity2 (2 pulmonary, 1 renal); 1 HFX @entity0 had fatal @entity2 . Response and @entity1 rates were similar for the two treatments, but infield (p = 0.054) and overall (p = 0.04) progression-free survival rates were better with HFX/PE. Median survivals were 18.9 months with HFX/PE and 10.6 months with HFX. Two-year survival rates were 36% for HFX/PE and 22% for HFX (p = 0.014). The differences in survival between HFX/PE and HFX remained borderline statistically significant (p = 0.0593) in the multivariate model, which included @entity3 , Karnofsky performance status (KPS), sex, and stage. HFX/PE is an effective regimen in @entity0 with inoperable @entity5 , although it is considerably more toxic, and is undergoing a comparison in a three-arm randomized phase III study against induction @entity4 / @entity8 plus standard once-daily RT and against @entity4 / @entity8 concurrent with standard RT.

title: Impact of adding concurrent chemotherapy to hyperfractionated radiotherapy for locally advanced @entity5 ( XXXX ): comparison of RTOG 83-11 and RTOG 91-06.

answer: @entity5


abstract: UNASSIGNED: It is known that specific alteration of rhythm in temperature (SART) stress produces @entity4 . However, it remains to be investigated whether SART stress induces @entity6 . In this study, we investigated the @entity3 in the SART stress model by pharmacological tools and @entity9 . Four-week-old @entity2 were exposed to repeated cold stress. @entity6 was measured by visceromotor response to @entity0 , and the effects of @entity11 and @entity7 on @entity6 were investigated in SART @entity2 . @entity9 was given by @entity5 injection into the left forepaw to induce @entity1 ( @entity1 ). SART stress induced @entity3 that was sustained at minimum for one week. In pharmacological analysis, alosetron and @entity7 improved SART stress-induced @entity3 . @entity9 induced @entity1 in normal conditions, but was disrupted in SART @entity2 . On the other hand, @entity10 mRNA in distal colon was not affected by SART stress. In conclusion, SART @entity2 exhibit several features of @entity6 in @entity8 , and may be a useful model for investigating the central modification of @entity4 control in @entity8 .

title: Specific alteration of rhythm in temperature-stressed XXXX possess features of abdominal pain in @entity8 patients.

answer: @entity2


abstract: OBJECTIVE: Data on the incidence of @entity4 ( @entity4 ) and @entity3 from population-based studies in Caucasian type 2 @entity1 @entity0 are lacking. To provide such data, a population-based cohort of type 2 @entity1 @entity0 was identified in Casale Monferrato, Italy, and prospectively examined from 1991 to 2001. RESEARCH DESIGN AND METHODS: During the follow-up period, @entity0 were regularly examined with centralized measurements of plasma @entity5 and HbA(1c). Independent predictors of progression to renal events were identified with multivariate Cox proportional hazards modeling, with sex, age, and individual follow-up time as confounders. RESULTS: We followed 1,408 of 1,540 (91.4%) @entity0 (average follow-up time 6.7 years, range 0.011-11.1); 10 new cases of @entity4 and 72 of @entity3 (plasma values of @entity5 >or=2.0 mg/dl) were identified, giving incidence rates/1,000 @entity0 -years of 1.04 (95% CI 0.56-1.94) and 7.63 (6.06-9.61), respectively. Cumulative risks for @entity3 adjusted for competing mortality were 6.1 and 9.3% after 20 and 30 years from diagnosis of @entity1 , respectively. Incidence rates and cumulative risks of @entity3 defined by plasma @entity5 values >1.5 mg/dl increased to 13.1/1,000 @entity0 -years, 8.6 and 14.8%, respectively. In Cox regression analysis, predictors of progression (after adjustment for confounders) were @entity2 (P = 0.078), diastolic blood pressure (P = 0.034), BMI (P = 0.03), and albumin excretion rate (AER) (P < 0.0001). CONCLUSIONS: We provide evidence that the individual risk of @entity4 and @entity3 is low. AER and diastolic blood pressure are independent predictors of progression. These findings underline the relevance of primary prevention to reduce the number of @entity1 @entity0 with @entity4 .

title: Low incidence of @entity4 and @entity3 in type 2 XXXX : a 10-year prospective study.

answer: @entity1


abstract: UNASSIGNED: A @entity2 represents an abnormal tissue growth that can arise from any ocular structure, such as eyelids, muscles or the optic nerve. At the eyelids, there are two main @entity2 types: @entity8 and @entity7 . @entity9 plays a crucial role in growth, invasion and @entity1 processes of any @entity2 . It is well known the fact that without new vessels formation @entity2 cannot exceed 1-2 mm diameter. Immunohistochemical analysis has been performed on 43 cases of primary @entity5 of the eyelid, diagnosed between 2010 and 2014 in the Laboratory of Pathological Anatomy of the University Emergency County Hospital of Craiova, Romania. Biological material was represented by surgical resection samples, coming from the Clinic of Ophthalmology the anteriorly named Hospital. Within the immunohistochemical study, we have evaluated @entity6 ( @entity6 ) and @entity3 ( @entity3 ) expression in a group of 43 cutaneous @entity5 of the eyelid, depending on the type and differentiation grade of the @entity2 . Of the 43 samples, 23 came from @entity0 with @entity8 and 20 came from @entity0 with @entity7 . In our study, @entity6 and @entity3 immunoexpression was superior for @entity7 , @entity8 , fact that was statistically significant. Regarding @entity7 , the immunoexpression of these two markers was superior in moderate  poor differentiated forms, compared to well differentiated forms, fact that was statistically significant. The markers used in this study were found to be associated with the acquisition of @entity4 and angiogenic phenotypes by analyzed @entity5 .

title: Assessment of @entity3 and @entity6 in the study of XXXX .

answer: @entity5


abstract: BACKGROUND: @entity1 ( @entity1 ) is a major contributor of maternal morbidity and mortality. Whether maternal race/ethnicity is associated with the risk of postpartum @entity1 remains unclear. METHODS AND RESULTS: We conducted a population-based, case-control study in Washington State, from 1987 through 2011. Cases comprised all @entity0 with selected ICD-9-CM codes for hospitalized @entity1 within 3 months post-delivery. Controls were randomly selected postpartum @entity0 who did not experience a @entity1 . Characteristics of @entity0 and their deliveries were abstracted from birth certificates. Using logistic regression models, we compared the risk of postpartum @entity1 in Black, Asian, and Hispanic @entity0 with that in non-Hispanic White @entity0 , after adjustment for maternal characteristics (age, BMI, parity, education), pregnancy complications, and delivery methods. RESULTS: Our study comprised 688 cases and 10,246 controls. Among controls, the mean age and BMI were 27.5 years and 26.3 kg/m(2) , respectively. Compared with White @entity0 , Black and Asian @entity0 had a greater and lower risk of postpartum @entity1 , respectively (adjusted OR 1.50, 95%CI 1.10-2.04 and OR 0.67, 95%CI 0.48-0.94). A lower risk was present in Hispanic @entity0 (adjusted OR 0.80, 95%CI 0.61-1.06), but was not statistically significant. In subgroups analyses, we observed an increased risk for Black compared with White @entity0 among @entity0 who delivered via cesarean section (OR 2.03, 95%CI 1.34-3.07) but not among vaginal deliveries (OR 1.03, 95%CI 0.61-1.74). CONCLUSIONS: Maternal race/ethnicity is associated with the risk of postpartum @entity1 , independently of other risk factors, and should be considered when assessing the use of thromboprophylaxis after delivery. This article is protected by copyright. All rights reserved.

title: Racial and ethnic differences in the risk of postpartum XXXX : a population-based, case-control study.

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity5 ), a disease-modifying therapy for @entity1 ( @entity1 ), causes @entity3 in a fraction of @entity0 . The clinical significance of this is unknown. Several cases of progressive multifocal @entity2 in lymphopenic @entity4 -treated @entity0 have raised concerns about drug safety. Since lymphocytes contribute to @entity1 pathology, @entity3 may also be a biomarker for response to the drug. OBJECTIVE: The objective of this manuscript is to evaluate risk factors for @entity5 -induced @entity3 and drug failure in a real-world population of @entity1 @entity0 . METHODS: We conducted a retrospective cohort study of 221 @entity0 prescribed @entity5 at a single academic medical center between March 2013 and February 2015. RESULTS: Grade 2-3 @entity3 developed in 17% of the total cohort and did not resolve during @entity5 treatment. Older age (>55), lower baseline absolute lymphocyte count and recent natalizumab exposure increased the risk of developing moderate to severe @entity3 while on @entity5 . @entity3 was not predictive of good clinical response or of breakthrough @entity1 activity on @entity5 . CONCLUSIONS: @entity3 develops in a significant minority of @entity5 -treated @entity0 , and if grade 2 or worse, is unlikely to resolve while on the drug. Increased vigilance in lymphocyte monitoring and infection awareness is particularly warranted in older @entity0 and those switching from natalizumab.

title: XXXX -associated @entity3 : Risk factors and clinical significance.

answer: @entity6


abstract: PURPOSE: With the advancement of laparoscopic techniques and instruments, laparoscopic approach for @entity3 has become an increasingly used procedure. But, there are few and limited studies about laparoscopic enuleation (LE) for @entity3 . Therefore, the purpose of this study was to present our experience and to evaluate the clinical outcome of LE for pancreatic benign or borderline @entity1 . METHODS: Between May 2005 and December 2011, 11 @entity0 who underwent LE were analyzed. Candidates for LE met the following criteria: benign or borderline malignant @entity4 , no involvement of main pancreatic duct, and outwardly growing @entity1 with small @entity1 bed. RESULTS: All 11 @entity0 (10 @entity0 and 1 @entity0 with a mean age of 43.1    11.9 years) who underwent LE were completed laparoscopically without conversion. The mean diameter of @entity1 was 4.0    3.3 cm and all cases had @entity1 at the final pathologic diagnosis. One @entity0 (9%) developed @entity5 and mean postoperative hospital stay was 5.5    1.7 days. During follow-up period (mean, 44.3    23.9 months), all @entity0 were alive with no recurrence or new onset of @entity2 . CONCLUSION: LE is a safe and effective procedure, and should be considered as a treatment option for @entity3 that do not involve the main pancratic duct and have an outgrowing aspect with small @entity1 bed.

title: Feasibility and outcomes of laparoscopic enucleation for XXXX .

answer: @entity4


abstract: The influence of @entity3 alleles on B-cell homeostasis was analyzed in 164 @entity0 with @entity1 ( @entity1 ). The percentages of @entity2 + B lymphocytes determined in the peripheral circulation of 94 retrospectively recruited @entity1 @entity0 followed a bimodal distribution. Two frequency peaks (B-cell(low) @entity0 and B-cell(high) @entity0 ) were separated by the population median of a B-cell frequency of 8.5% of all lymphocytes. Human leucocyte antigen genotyping revealed that the B-cell(low) @entity0 were more frequently positive for the @entity1 -associated @entity3 @entity5 ( @entity5 ) than were B-cell(high) @entity0 . Accordingly, @entity5 -positive @entity0 had lower @entity2 percentages in the rank-sum analysis when compared with @entity5 -negative @entity0 , and were markedly B lymphocytopenic when compared with a healthy control group. To confirm the differential frequencies of @entity2 + B cells, absolute numbers in peripheral blood were determined prospectively in a cohort of 70 @entity1 @entity0 with recent onset disease. @entity5 -positive @entity0 were found to have lower absolute numbers of circulating @entity2 + B cells. B-cell counts below the mean of the study population were associated with higher acute phase response and with increased levels of rheumatoid factor IgA. No correlation between absolute numbers of circulating B cells and radiographic progression of joint destruction was seen. The influence of immunogenetic parameters on B-cell homeostasis in @entity1 reported here has not been described previously. The clinical relevance of @entity4 in @entity1 will be further investigated in longitudinal studies.

title: XXXX in @entity1 is associated with the @entity3 @entity5 and increased acute phase response.

answer: @entity4


abstract: Numerous clinical studies have reported that ingestion of @entity7 reduces the risk of @entity1 . However, the mechanisms by which this occurs remain unclear. In this @entity0 study, the metabolic-enhancing activity of a 10 mg/kg mixture of @entity10 fraction derived from @entity7 (FL) was compared with the same single dose of @entity9 (EC). Resting energy expenditure (REE) was significantly increased in @entity0 treated with the FL versus the group administered the distilled water vehicle (Cont) during periods of ad libitum feeding and fasting. @entity0 were euthanized under the effect of anesthesia 2, 5, and 20 hr after treatment with FL or Cont while subsequently fasting. The mRNA levels of the @entity5 ) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha ( @entity8 ) in brown adipose tissue (BAT) were significantly increased 2 hr after administration of FL. @entity6 and @entity8 in the gastrocnemius were significantly increased 2 and 5 hr after administration of the FL. The concentrations of phosphorylated AMP-activated protein kinase (AMPK) 1a were found to be significant in the gastrocnemius of @entity0 2 and 5 hr after ingesting FL. However, these changes were not observed following treatment with EC. Plasma was collected for measurement of @entity4 levels in other animals euthanized by decapitation 2 and 4 hr after their respective group treatment. Plasma @entity3 level was significantly elevated 2 hr after treatment with FL; however, this change was not observed following the administration of EC alone. The present results indicated that FL significantly enhanced @entity2 energy expenditure, as evidenced by an accompanying increase in the type of gene expression responsible for thermogenesis and lipolysis, whereas EC exhibited this less robustly or effectively. It was suggested the possible interaction between thermogenic and lipolytic effects and the increase in plasma @entity4 concentrations after administration of a single oral dose of FL.

title: Enhancement of energy expenditure following a single oral dose of flavan-3-ols associated with an increase in XXXX secretion.

answer: @entity4


abstract: Differential diagnosis between @entity6 / @entity10 / and @entity6 can be very difficult. The main clinical symptoms in @entity0 with @entity6 are @entity7 , @entity4 , @entity5 and new onset of @entity1 . Unfortunately, the same symptoms could be observed in @entity0 with @entity8 too. Imaging methods as computed tomography /CT/ scan, magnetic resonance imaging /MRI/ and endosonography /EUS/; together with serological examination /IgG4 and Ca 19--9/ play the important role in differentiation @entity6 from @entity6 . Extrapancreatic findings are distinctive in @entity0 with @entity6 . In some cases the pancreatic biopsy is indicated, mainly in @entity0 with focal or multifocal form of @entity6 . Response to @entity3 /decreased pancreatic or extrapancreatic lesion or damage/ is distinctive to @entity10 . In clinical practice, CT scan seems to be the most reasonable/ tool for examining the @entity0 with @entity9 with or without present pancreatic mass/. Stratification the @entity0 with possible @entity10 versus @entity6 is important. In @entity0 with @entity10 it may avoid pancreatic resection, as well as incorrect @entity2 treatment in @entity0 with @entity8 .

title: Differentiating @entity6 from XXXX .

answer: @entity6


abstract: The use of plant extract in the biosynthesis of nanoparticles (NPs) can be an eco-friendly approach and have been suggested as a possible alternative to classic methods namely physical and chemical procedures. In this study, the biosynthesis of @entity4 ( @entity5 ) NPs by both "conventional heating" ( @entity8 ) and "microwave irradiation" ( @entity9 ) methods has been reported. Stable and spherical ZnONPs were produced using @entity10 and flesh extract of Rosa canina fruit (rosehip) which was used as a precursor. The flesh extract acts as a reducing and capping agent for generation of ZnONPs. The structural, morphological and colloidal properties of the as-synthesized NPs have been confirmed by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), Fourier transform Infrared (FT-IR) and Dynamic Light Scattering (DLS). In comparison with the @entity8 method, the @entity9 method has some advantages such as significantly short reaction time (within 8min) owing to the high heating rate and thus the accelerated reaction rate. Both methods led to the synthesis of nearly identical NPs with respect to shape and size according to the results of DLS, XRD and SEM techniques. The possible mechanism for synthesis pathway has been proposed based on FT IR results, XRD patterns, potentiometric data and antioxidant activity. In addition, the antibacterial activity of as-prepared ZnONPs was investigated against several bacteria such as @entity7 , @entity3 , @entity6 . Moreover, the efficacy of ZnONPs to treat @entity0 cell lines were measured by means of cell viability test via @entity1 assay in which concentrations of 0.05 and 0.1mg/mL of ZnONPs induced a very low @entity2 . Thus, the present investigation reveals that ZnONPs have the potential for various medical and industrial applications.

title: Biofabrication of XXXX nanoparticles using fruit extract of Rosa canina and their toxic potential against bacteria: A mechanistic approach.

answer: @entity4


abstract: PURPOSE: The effect of @entity5 ( @entity5 ) on tissue @entity1 and @entity4 induced with @entity2 extravasation was studied. MATERIALS AND METHODS: Adult @entity0 -Albino @entity0 (n=36) were used in the study. @entity2 (0.4mg/300 g) was applied subcutaneously to abdominal wall. In group I (n=18), half hours after @entity2 injection, @entity5 6 microg/300 mg was applied subcutaneously to the same localization. In group II (n = 18) same amount of physiologic saline (0.5 ml) were given subcutaneously to the injection site (as vehicle control groups). Group II and I were examined for induration or @entity4 on 7th and 21st day. After evaluating the lesions, the injection sites were excised. @entity3 (5-HP) values of dry tissue samples were calculated and histopathologic examination was done. RESULTS: At day seven there were four and eight @entity4 in groups I and II, while there were four and 14 @entity4 in the second evaluation at day 21st (p<0.05). 5-HP values of the groups were as follows. 97.43+/-20.39 in group land 91.34+/-22.26 in group II. Although there was an increase in epithelization, eosinophil and lymphocyte infiltration and mast cell number in group I in histopathologic examinations only the increase in angiogenesis in group I was found to be statistically significant (p<0.05). CONCLUSION: It can be concluded that @entity5 may have beneficial effect in the treatment of @entity2 induced tissue @entity1 .

title: The effect of XXXX (granulocyte macrophage colony stimulating factor) on @entity2 induced tissue @entity1 and wound healing.

answer: @entity5


abstract: PURPOSE: To evaluate the activity and safety of the @entity8 , @entity3 and bevacizumab combination, administered biweekly, in pretreated @entity1 with @entity12 -negative @entity0 ( @entity0 ). @entity1 AND METHODS: @entity1 with @entity12 -negative @entity0 , and disease progression after at least one prior line of chemotherapy, were treated with @entity8 50  mg/m(2), @entity3 1,500  mg/m(2) and bevacizumab 10  mg/kg every 2  weeks. Bevacizumab was continued until disease progression. RESULTS: Forty-eight @entity1 have been enrolled. Their median age was 61  years, 95.8  % had a performance status 0-1, 83.3  % had hormone receptor-positive disease, and 47.9  % had received one prior line of chemotherapy. All @entity1 were evaluable for @entity4 and 45 for response. Partial response was achieved in 20 @entity1 [PR  =  44.4  %, 95  % confidence interval (CI) 29.9-59  %] and disease stabilization in 15 (33.3  %). The median progression-free survival was 7.1  months (95  % CI 4.7-9.5  months) and the median overall survival 21.1  months (95  % CI 10.3-31.9  months). Grade 3-4 @entity10 occurred in 19 @entity1 (39.6  %) and @entity10 in 2 (4.2  %). Most common grade 2-3 non-hematologic adverse events included @entity6 (10.4  %), @entity5 (10.5  %), @entity13 (12.5  %) and @entity9 (31.3  %), whereas grade 2 @entity7 and @entity2 occurred in 6.3 and 10.4  %, respectively. There were no grade 4 @entity11 or toxic deaths. CONCLUSION: The combination of @entity8 , @entity3 and bevacizumab has promising activity and manageable @entity4 as salvage chemotherapy for @entity12 -negative @entity0 @entity1 .

title: XXXX , @entity3 and bevacizumab as salvage chemotherapy for @entity12 -negative @entity0 .

answer: @entity8


abstract: OBJECTIVES: To assess functional changes measured by cerebral blood flow (CBF) in the presymptomatic stage of @entity3 linked to chromosome 3 ( @entity3 -3) caused by a truncating mutation in @entity5 . DESIGN: Case-control study. SETTING: A memory clinic and tertiary referrals centre for @entity1 and @entity6 . @entity0 : The authors included 11 presymptomatic @entity5 mutation carriers and seven first-degree-related family non-carriers. @entity0 were MRI scanned twice with an interval of 15 months. PRIMARY AND SECONDARY OUTCOME MEASURES: Local functional changes in brain tissue perfusion were measured as CBF with two different MR techniques, gradient echo (GRE) and @entity4 ( @entity4 ), focusing on CBF in all cerebral vessels (GRE) and cerebral capillaries ( @entity4 ), respectively. As planned, data analysis included co-registration of perfusion images to structural T1 images. Perfusion data were then extracted from seven regions-of-interest, normalised to white matter and statistically compared between carriers and non-carriers. RESULTS: For @entity4 , contrasts between carriers and non-carriers showed significant differences in temporal, occipital and parietal lobes and in hippocampus. There was no evidence of changes from baseline to follow-up. For GRE, there were no significant differences between carriers and non-carriers. CONCLUSIONS: Significantly decreased CBF was found in presymptomatic @entity5 mutation carriers in @entity2 . Comparing @entity4 with GRE, data indicate that @entity3 -3 vascular pathology might primarily affect brain capillaries.

title: Presymptomatic cerebral blood flow changes in XXXX mutation carriers of @entity1 ( @entity3 -3), measured with MRI.

answer: @entity5


abstract: PURPOSE: The aim of this study was to investigate the sensitization, pharmacokinetics, and absorption of @entity3 after corneal transplantation. METHODS: New Zealand albino @entity0 were divided into normal and corneal transplantation groups. Each group was divided into 5 subgroups--saline, blank matrix, high-dose, medium-dose, and low-dose, respectively. There were 10 @entity0 in each subgroup. One drop (25  L) of @entity3 was administered topically to both eyes of the @entity0 4 times daily for 30 days. Thirty days later, 5 @entity0 of each subgroup were sacrificed after the administration of the last dose. Both eyes were enucleated; the left eye was used for pathologic examination and the right eye for the determination of @entity3 distribution. The other 5 @entity0 in each subgroup were sacrificed 14 days after the former 5 @entity0 were sacrificed, and their eyes were enucleated for pathologic examination and tissue distribution determination as the former 5 @entity0 in each subgroup (the second batch). RESULTS: @entity2 staining and local ocular reaction provided evidence that there were no significant differences between control and @entity3 -instilled eyes in the @entity0 model at any of the tested doses. Histologic examination revealed no @entity1 in the @entity0 instilled with any doses of @entity3 eyedrop. The peak serum concentration (C(max)) of systemic absorption ranged from 4.31  0.79 ng/mL to 14.89  6.85 ng/mL. CONCLUSION: Our study suggests that up to 0.1% @entity3 administered 4 times a day (q.i.d.) topically is safe for the @entity0 eye. However, further safety studies are required in view of systemic adverse effects.

title: Ocular safety and pharmacokinetics study of XXXX suspension eye drops after corneal transplantation.

answer: @entity3


abstract: Both @entity4 (near @entity2 ) and @entity5 ( @entity3 ) polymorphisms have been consistently associated with increased risk of @entity1 and with body mass index (BMI) variation. An effect of both polymorphisms on satiety has recently been suggested. We genotyped @entity4 and @entity5 in 5764 relatives from 1109 French pedigrees with @entity1 , 1274 Swiss class III @entity1 adults as well as in 4877 French adults and 5612 Finnish teenagers from two randomly selected population cohorts. In all subjects, eating behaviour traits were documented through questionnaires. We first assessed the association of both single nucleotide polymorphisms with BMI and then studied eating behaviour. Under an additive model, the @entity4 -C @entity2 allele showed a trend towards higher percentages of snacking in both French @entity1 @entity0 (P=0.01) and Swiss @entity1 adults (P=0.04) as well as in adolescents from the Finnish general population (P=0.04). In French adults with @entity1 , this allele tended to be also associated with a higher Stunkard hunger score (P=0.02) and in @entity1 @entity0 with a higher prevalence of eating large amounts of food (P=0.04). However, no consistent association of the @entity3 @entity5 -C allele and available eating behaviour trait was found in our studied populations. The @entity4 -C allele nearby @entity2 may modulate eating behaviour-related phenotypes in European @entity1 and randomly selected populations, in both @entity0 and adults, supporting a regulatory role of this genetic variant on eating behaviour, as previously shown for @entity2 non-synonymous loss-of-function mutations. The potential effect of the @entity1 -associated @entity3 gene on eating behaviour deserves additional investigation.

title: Common genetic variation near XXXX is associated with eating behaviour patterns in European populations.

answer: @entity2


abstract: Detection of small numbers of @entity0 cells in @entity1 blood, aphereses, and bone marrow has become increasingly important as data have accumulated showing immunocytochemically (ICC) positive @entity2 cells in up to 50% of @entity1 with @entity0 , who were initially thought to be cured of their disease but later relapsed. The ability to rule out the presence of micrometastatic disease at any stage of the clinical management protocol, whether before, during, or after therapy, would provide a useful monitoring and diagnostic tool for both the clinician and the scientist. Monitoring for the presence of @entity3 ( @entity3 ) is traditionally performed using ICC. A more recently established RT-PCR technique uses a molecular marker (the presence of the @entity4 , @entity4 , transcript) to identify @entity3 in @entity1 samples, with a level of sensitivity reported to be one @entity2 cell in 10(6) nucleated cells. This level of sensitivity is generally higher than that claimed for ICC. Based on the discriminating results of this first study, a number of laboratories have evaluated this technique for its diagnostic potential. Results from several laboratories showed a higher than expected false positive rate due to a variety of identified and unidentified sources. Therefore, the current study was designed to achieve two aims: to establish the level of sensitivity and specificity of the RT-PCR technique and to dissect out the possible variables that may contribute to a false positive result using this molecular approach. To accomplish the first goal, two simulation strategies were used, limited dilution of @entity2 cells into apheresis harvests and semi-quantitative PCR using stepwise dilutions of extracted RNA from @entity2 cells in apheresis harvests. The second goal was accomplished by performing sequential blood drawings with variably timed sample processing to identify some of the more common variables (time, anticoagulant, sample sequence) that may contribute to false positive results. Of three variables investigated, including type of blood preservative, sequence of blood tube collection, and time point of sample processing, each may contribute to a false positive result. In addition to these problems, known events involving illegitimate transcription of specific genes nonspecifically in tissue is also a potential source of false positive results. These issues may be further compounded by lack of attention to the more common methodologic problems encountered in any laboratory using the PCR technique. However, recommendations can be developed for the effective application of this technique, whose greatest strength is the demonstration of @entity2 negativity of the sample.

title: Comparison of molecular XXXX reverse transcriptase polymerase chain reaction ( @entity4 RT-PCR) and immunocytochemical detection of micrometastatic @entity0 cells in hematopoietic harvests.

answer: @entity4


abstract: Relapses of @entity5 are usually treated with @entity2 , initially in three to four daily divided doses. The divided-dose regimen may cause poor @entity0 compliance and greater adrenal suppression. In a prospective randomized controlled trial, we compared the efficacy of @entity2 in inducing remission of @entity5 , when given either as a single dose or in divided doses. @entity0 with steroid-responsive @entity5 with relapse were randomized to receive @entity2 2 mg/kg per day, either as a single morning dose or in three divided doses for 2 weeks, followed by 1.5 mg/kg on every alternate day for 4 weeks. Parents tested the urine for protein daily until remission (nil @entity3 for 3 consecutive days). The duration between initiation of treatment and achievement of remission was recorded. Of 106 @entity0 , 94 (47 each in single-dose and divided-dose groups) completed the study. The @entity0 in the two groups were similar in relation to age, sex, number of relapses in the preceding year, and blood levels of @entity4 , albumin, and @entity1 . The mean time for achievement of remission in the single- and divided-dose groups was 8.6 and 8.5 days, respectively (P = 0.94, power 96%). After 9 months' follow-up, there were no differences in the frequency of relapses and cumulative dose of @entity2 received in the two groups. The observations suggest that @entity2 administered in a single daily dose or in divided doses is equally effective in inducing remission in @entity0 with relapsing @entity5 .

title: Single- versus divided-dose XXXX therapy for relapses of @entity5 .

answer: @entity2


abstract: Glucocorticoids are widely used in the therapy of inflammatory, autoimmune, and @entity0 . As the end-effectors of the @entity3 , endogenous glucocorticoids also play an important role in suppressing innate and cellular immune responses. Previous studies have indicated that glucocorticoids inhibit @entity2 and enhance Th2 cytokine secretion. IL-12 promotes @entity2 cell-mediated immunity, while @entity4 stimulates Th2 humoral-mediated immunity. Here, we examined the regulatory effect of glucocorticoids on key elements of IL-12 and @entity4 signaling. We first investigated the effect of @entity1 on IL-12-inducible genes and showed that @entity1 inhibited IL-12-induced IFN-gamma secretion and IFN regulatory factor-1 expression in both NK and T cells. This occurred even though the level of expression of IL-12 receptors and IL-12-induced Janus kinase phosphorylation remained unaltered. However, @entity1 markedly inhibited IL-12-induced phosphorylation of @entity6 without altering its expression. This was specific, as @entity4 -induced @entity7 phosphorylation was not affected, and mediated by the glucocorticoid receptor, as it was antagonized by the glucocorticoid receptor antagonist @entity5 . Moreover, transfection experiments showed that @entity1 reduced responsiveness to IL-12 through the inhibition of @entity6 -dependent IFN regulatory factor-1 promoter activity. We conclude that blocking IL-12-induced @entity6 phosphorylation, without altering @entity4 -induced @entity7 phosphorylation, appears to be a new suppressive action of glucocorticoids on the @entity2 cellular immune response and may help explain the glucocorticoid-induced shift toward the Th2 humoral immune response.

title: Inhibition of @entity2 immune response by glucocorticoids: XXXX selectively inhibits IL-12-induced @entity6 phosphorylation in T lymphocytes.

answer: @entity1


abstract: UNASSIGNED: Functional magnetic resonance imaging (fMRI) of the blood @entity2 level dependent (BOLD) response has commonly been used to investigate the neuropathology underlying @entity3 in @entity0 with @entity4 ( @entity4 ) by examining the positive phase of the BOLD response, assuming a fixed shape for the @entity5 ( @entity5 ). However, the individual phases (positive and post-stimulus undershoot (PSU)) of the @entity5 may be differentially affected by a variety of underlying pathologies. The current experiment used a multisensory detection task with a rapid event-related fMRI paradigm to investigate both the positive and PSU phases of the @entity5 in @entity4 and @entity1 ( @entity1 ). Behavioral results indicated no significant group differences during task performance. Analyses that examined the shape of the @entity5 indicated two distinct group differences. First, @entity4 exhibited a reduced and/or prolonged PSU following normal task-related positive BOLD activation in secondary auditory and visual sensory areas relative to @entity1 . Second, @entity4 did not show task-induced deactivation in the anterior node of the @entity6 (aDMN) relative to @entity1 . In contrast, when performing traditional analyses that focus on the positive phase, there were no group differences. Interestingly, the magnitude of the PSU in secondary auditory and visual areas was positively associated with the magnitude of task-induced deactivation within the aDMN, suggesting a possible common neural mechanism underlying both of these abnormalities (failure in neural inhibition). Results are consistent with recent views that separate neural processes underlie the two phases of the @entity5 and that they are differentially affected in @entity4 . Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

title: Hemodynamic response function abnormalities in XXXX during a multisensory detection task.

answer: @entity4


abstract: BACKGROUND AND AIM: Cell apoptosis in @entity4 @entity0 plays a pivotal role in the pathogenesis of @entity1 . This study aimed to determine the prognostic value of leukocyte apoptosis in @entity0 with severe @entity1 . METHODS: Leukocyte apoptosis was determined by flow cytometry. The values of @entity5 , @entity3 .7, and @entity6 (7AAD) for each subtype of leukocyte were analyzed in 87 @entity0 with severe @entity1 and 27 controls. RESULTS: The percentages of apoptosis ( @entity3 .7 [%]) in the leukocyte subsets were significantly higher in the @entity0 with severe @entity1 than in the controls. The percentages of @entity3 .7 in leukocyte apoptosis, @entity3 .7 in lymphocytes apoptosis, and @entity5 +7AAD in monocytes apoptosis were significantly higher in non-survivors than in survivors. Levels of @entity3 .7 in lymphocytes apoptosis, @entity5 +7AAD in monocytes apoptosis, and serum @entity2 were all independently predictive of mortality. CONCLUSION: Leukocyte apoptosis is significantly higher in @entity0 with severe @entity1 . The percentages of late lymphocyte and monocyte apoptosis may be predictive of outcome in such @entity0 . Aside from serum @entity2 , @entity3 .7 level in lymphocyte apoptosis is also a useful predictor of outcome on admission to the emergency department.

title: The prognostic value of leukocyte apoptosis in @entity0 with severe XXXX at the emergency department.

answer: @entity1


abstract: UNASSIGNED: @entity6 ( @entity6 ) is a devastating type of @entity1 , potentially causing loss of motor and sensory function. Principally, @entity6 is either categorized as preganglionic or postganglionic, with the early establishment of injury level being crucial for choosing the correct treatment strategy. Despite diagnostic advances, the need for a reliable, non-invasive method for establishing the @entity2 . We studied the usefulness of in vivo magnetic resonance imaging (MRI) of the spinal cord for determination of injury level. The findings were related to neuronal and glial changes. @entity0 underwent unilateral L4 _ L5 ventral roots @entity3 or sciatic nerve axotomy. The injuries served as models for pre- and postganglionic @entity6 , respectively. MRI of the L4/L5 spinal cord segments 4 weeks after @entity3 showed ventral horn (VH) shrinkage on the injured side compared to the uninjured side. Axotomy induced no change in the VH size on MRI. Following @entity3 , histological sections of L4/L5 revealed shrinkage in the VH grey matter area occupied by @entity4 -positive neurons, loss of microtubular-associated protein-2 positive @entity5 ( @entity7 ), @entity9 (PanNF), @entity8 -positive synapses (SYN) and increase in immunoreactivity for the microglial OX42 and astroglial GFAP markers. Axotomy induced no changes in @entity4 -reactivity, modest decrease of @entity7 immunoreactivity, no changes in SYN and PanNF labelling, and a modest increase in OX42 and SYN labeling. Histological and radiological findings were congruent when assessing changes after axotomy, while MRI somewhat underestimated the shrinkage. This study indicates a potential diagnostic value of structural spinal cord MRI following @entity6 .

title: Differentiation of Pre- and XXXX Using MRI of the Spinal Cord.

answer: @entity1


abstract: BACKGROUND: To achieve optimum drug delivery of Interferon-alpha in treatment of @entity2 , a regimen consisting of its daily intramuscular administration, in combination with oral @entity3 , was designed and carried out. Its efficacy is examined retrospectively. METHODS: In our department 7 @entity0 with disseminated @entity2 were treated with daily intramuscular injection of interferon-alpha (3 x 10(6) IU) and daily oral administration of @entity3 . All @entity0 was nehprectomized before initiation of the regimen. RESULTS: Two @entity0 achieved complete, and three @entity0 achieved partial response radiographically (Overall response rate 71%). Metastatic sites of responders were lung (4) and pleura (2). The time required until response was 3.9 (median 5.4) months. In two responders, new lesions appeared in other organs despite durable response in initial pulmonary metastatic sites. There were two no-responders, one @entity0 is alive with stable disease and the other @entity0 died for progression of the disease. In all, two @entity0 died of disease, one died for other cause, one surviving without evidence of disease, and three are surviving with disease. No significant side effect was noted in these seven @entity0 . CONCLUSIONS: This regimen can be carried out on outpatient basis and considerable response can be expected for @entity1 .

title: [Combination therapy of daily intramuscular injection of interferon-alpha and oral administration of XXXX for advanced @entity2 ].

answer: @entity3


abstract: @entity3 are the leading cause of @entity2 after noncardiac surgery. Despite theoretical benefits, @entity4 channel blockers (CCB) are not widely used in the perioperative setting. This systematic review assessed the efficacy of CCBs during noncardiac surgery. MEDLINE, EMBASE, Science Citation Index, PubMed, and reference lists were searched without language restriction for randomized controlled trials (RCT) evaluating CCBs during noncardiac surgery. Two reviewers independently abstracted data on @entity2 , @entity5 ( @entity5 ), @entity1 , @entity8 ( @entity8 ), and @entity6 ( @entity6 ). Treatment effects were calculated as relative risks (RR) with 95% confidence intervals (CI). Eleven studies (1007 @entity0 ) were included. CCBs significantly reduced @entity1 (RR, 0.49; 95% CI, 0.30-0.80; P = 0.004) and @entity8 (RR, 0.52; 95% CI, 0.37-0.72; P < 0.0001). CCBs were associated with trends towards reduced @entity2 and @entity5 . In post hoc analyses, CCBs significantly reduced @entity2 / @entity5 (RR, 0.35; 95% CI, 0.15-0.86; P = 0.02) and major morbid events (MME), defined as @entity2 , @entity5 , or @entity6 (RR, 0.39; 95% CI, 0.17-0.89; P = 0.02). In subgroup analyses, @entity7 significantly reduced @entity1 , @entity8 , @entity2 / @entity5 , and MMEs. This meta-analysis shows CCBs significantly reduced @entity1 , @entity8 , and combined end-points in the setting of noncardiac surgery. The majority of these benefits are attributable to @entity7 , suggesting the need for further evaluation of this drug in a large RCT.

title: XXXX channel blockers for reducing cardiac morbidity after noncardiac surgery: a meta-analysis.

answer: @entity4


abstract: @entity5 is regarded as a serious mental disturbance, where @entity2 and strong resistance to treatment are symptomatic features. In many cases it leads to extreme devastation or even to death. Effective treatment of this @entity1 remains a challenge for clinicians and researchers. Since the 90-ies of the previous century there has been a rise in the free access to the internet. At present over a billion @entity0 all over the world use it. What young @entity0 look for in the internet is not only information, but also friends, support or entertainment. For last a few years, a phenomenon of pro- @entity3 has been present in the Internet, connecting @entity0 who claim that @entity3 is a "lifestyle" rather than a @entity2 , which should be treat. They communicate with each other through the internet blogs, forums and popular social networking sites, creating a virtual community. The pro-ana community is made up of adolescent @entity0 and young @entity0 who decide on dieting. Pro- @entity3 is still a poorly known phenomenon, especially in Poland. It seems to be very important to take a note on this phenomenon in the face of an increasing prevalence of @entity4 in the last years.

title: [Friends of virtual Ana--the phenomenon of pro- XXXX in the Internet].

answer: @entity3


abstract: BACKGROUND: Measures of arterial stiffness could be affected by the presence of @entity3 ( @entity3 ) and especially an intraluminal @entity2 (ILT). We, therefore, sought to study this possible connection by measuring pulse wave velocity ( @entity1 ) and pulse wave analysis (PWA) including augmentation index adjusted to heart rate 75(Aix75) in @entity0 with @entity3 +/- ILT. @entity0 AND METHODS: @entity1 and PWA were measured in male @entity0 with @entity3 from an ongoing Danish @entity3 screening trial. Information on blood pressure, medications, BMI and smoking status was obtained at inclusion. RESULTS: In total, 157 @entity0 were included. Mean age was 73 years. Mean @entity3 size was 42.2 mm. Fifty-six of the @entity0 had an intraluminal @entity2 , and @entity0 with @entity3 and ILT had a significantly higher Aix75 than @entity0 with @entity3 but without ILT (Mean = 28.3    1.4 SEM vs. 24.9    0.81, p=0.027), a difference that was also significant when adjusting for @entity3 size, blood pressure and age. There was no difference in @entity1 between the groups. CONCLUSIONS: Haemodynamic properties of the aorta are affected by the presence of ILT in @entity0 with @entity3 that is not explained by aortic size. Alternatively, these findings could be explained by associations between ILT and properties of the left ventricle.

title: Comparison of two devices for measuring exercise transcutaneous oxygen pressures in XXXX with claudication.

answer: @entity0


abstract: OBJECTIVE: To report the efficacy and outcomes of transcervical resection of the endometrium ( @entity7 ) in treatment of @entity2 . METHODS: 400 @entity0 with @entity2 due to fatigue causes who had failed in medical therapy and did not desire pregnancy and surgery underwent @entity7 under hysteroresectoscope. Among them, 72 @entity0 with submucous @entity4 less than 5cm in diameter had their @entity4 resected simultaneously, 366 cases were followed up postoperatively for 3 months to 4 years. RESULTS: @entity7 was performed successfully except 16 cases, giving a success rate of 95.6%. Three cases sustained uterine perforation. During follow-up, 146 cases (41.7%) became @entity6 , 119 (34.0%) had only spotting. The remaining 85 (24.3%) had normal periods. 78.3% of the cases who previously had @entity3 had relieved their @entity1 . Long-term complications were recurrent abnormal uterine bleeding (22 cases 13 of them had a second operation), @entity8 (5) and @entity5 (4 cases). CONCLUSION: @entity7 is an effective procedure in treating @entity2 and @entity4 .

title: [Analysis of the outcomes of transcervical resection of endometrium in 400 cases with XXXX ].

answer: @entity2


abstract: In most cases the diagnosis of any molar @entity7 in @entity6 is made at an advanced stage, so that permanent restoration of the diseased teeth is not feasible. Complications such as @entity4 and @entity3 due to @entity2 as a result of dentogenous @entity5 and following dentosurgical procedures have been described in @entity0 medicine and in veterinary medicine. Twenty @entity0 were available for examination from the Clinic for @entity6 of the School of Veterinary Medicine Hannover with molar @entity7 in upper or lower jaw. As a result of this disease the infected tooth had to be removed surgically. The aim of this study was to determine the presence of and to identify microbes in 20 @entity0 . Swab samples were taken from infected pulpa, from dental abscesses and from involved nasal sinuses. The samples were examined microbiologically and tested for aerobes and anaerobes at the same time. Infectious agents were found in 19 of 20 @entity6 . In all, 27 different species of infectious agents were isolated, including both aerobic and anaerobic microbes. Fifteen @entity0 (75%) showed a mixed flora. Further differentiation indicated a preponderance of the group of gram-negative obligatory anaerobic agents isolated from a total of 17 @entity6 . In all these samples there was a high concentration of infectious agents of these genera, the most common of which were Prevotella spp (n = 16) and Fusobacterium spp. (n = 15). Pre-surgical antibacterial therapy is recommended to reduce the risk of intra- and/or post-surgical @entity4 and its serious consequences. In light of these microbiological results and considering the high degree of resistance among all anaerobic microbes, all @entity0 in this study were treated with @entity1 .

title: [Bacteriological findings for endodontical and apical molar @entity7 in the XXXX ].

answer: @entity6


abstract: The study evaluates whether the @entity4 ( @entity4 ) @entity1 is an adequate model to study mechanisms that underlie differences in tissue response after @entity2 . Postangioplasty studies of @entity0 coronary arteries have revealed that healing and restenotic processes differ depending on whether the laceration is limited to the @entity3 plaque or whether injury extends into the media. Forty-five homozygous @entity4 @entity1 underwent percutaneous transluminal angioplasty of the left subclavian artery. The inflated arterial segment was studied histologically at 3, 7, 14, 28, and 56 days, using conventional and immunohistochemical techniques to identify macrophages, smooth muscle cell (SMC) phenotypes, and cell proliferation. Electron microscopy was done to study reendothelialization. There were marked differences in response between those segments with medial injury and those with injury limited to the @entity3 plaque tissues. The latter category shows a distinct retardation in redifferentiation of SMCs, confirming previous observations in @entity0 coronary arteries. In these segments, moreover, cell proliferation occurred mainly in macrophages and spindle cells. Medial injury showed a more florid fibrocellular response, as in @entity0 coronary arteries, with cell proliferation initially confined to areas with dedifferentiated SMCs in the preexistent media and, once neointimal tissue was formed, among spindle cells also. The similarities with the repair processes encountered in postangioplasty @entity0 coronary arteries suggest that the @entity4 @entity1 is an adequate model to study differences in the response related to different types of @entity2 .

title: The @entity4 XXXX is a suitable experimental model to study differences in tissue response between intimal and medical injury after balloon angioplasty.

answer: @entity1


abstract: Previous studies have revealed that @entity1 can activate transcription of the @entity2 gene promoter through an @entity3 ( @entity3 ) binding site in @entity0 macrophage RAW264.7. In this study, we determined that, in addition to @entity3 , @entity4 and delta were also involved in @entity1 -induced gene expression of @entity2 . By transient transfection with 5'-deletion mutants of the @entity2 promoter, we found that there were two @entity1 -responsive elements in the promoter of the @entity0 @entity2 gene. Analysis of these two regions by gel shift assay suggested that @entity3 and @entity4 and delta were bound to these two regions, respectively. By site-directed mutagenesis, we found that disruption at both the @entity3 and C/EBP binding sites almost completely blocked the @entity1 response. By gel shift assay and Western blotting, we found that the DNA binding complex and protein expression of @entity4 and delta were increased by @entity1 treatment, but these results were not found for @entity3 . Overexpression of @entity4 or @entity5 , respectively, activated the promoter of the @entity2 gene, and they were enhanced by @entity1 . Coimmunoprecipitation experiments in intact cells indicated that @entity1 stimulated interaction between @entity3 and @entity4 and delta. These results suggested that the interaction between @entity3 and @entity4 and delta induced by @entity1 cooperatively activated expression of the @entity2 gene. The increase of @entity4 and delta proteins and the enhancement of transactivation activity of @entity4 and delta by @entity1 treatment, at least in part, explain the activation of @entity2 gene expression.

title: Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of XXXX in @entity0 macrophages.

answer: @entity2


abstract: Two indigenous Cameroonian taurine @entity1 breeds (Namchi and Kapsiki) were evaluated for trypanosusceptibility following inoculation with Trypanosoma congolense. The degree of @entity4 ancestry in the experimental animals was assessed using 6 microsatellite markers which are known to have certain unique alleles which are diagnostic of @entity4 genetic input. Their response to the @entity0 was compared to that of known trypanotolerant (N'Dama) and trypanosusceptible (Ngaoundere Gudali) @entity1 . The Namchi and the N'Dama controlled the development and severity of @entity3 and parasitaemia better than the Kapsiki and the Gudali. For these parameters, there was no significant difference between the N'Dama and Namachi nor between the Kapsiki and Gudali. Similarly, @entity2 showed significant breed variation. The N'Dama lost the least weight and the Kapsiki the most. @entity4 introgression in the Namchi was comparable to that in the N'Dama while that of the Kapsiki breed was higher, indicating a high level of cross breeding. From the results, the Namchi are considered trypanotolerant while the Kapsiki are trypanosusceptible. The potential exploitation of the indigenous Namchi @entity1 is discussed.

title: Susceptibility of the Namchi and Kapsiki @entity1 of Cameroon to trypanosome XXXX .

answer: @entity0


abstract: The seasonal dynamics and spatial distributions of Anopheles mosquitoes and @entity3 parasites were studied for one year at 30 villages in Malindi, Kilifi, and Kwale Districts along the coast of Kenya. Anopheline mosquitoes were sampled inside houses at each site once every two months and @entity1 parasite prevalence in local school @entity0 was determined at the end of the entomologic survey. A total of 5,476 @entity2 s.l. and 3,461 An. funestus were collected. Species in the An. gambiae complex, identified by a polymerase chain reaction, included 81.9% An. gambiae s.s., 12.8% An. arabiensis, and 5.3% An. merus. @entity2 s.s. contributed most to the transmission of @entity3 along the coast as a whole, while An. funestus accounted for more than 50% of all transmission in Kwale District. Large spatial heterogeneity of transmission intensity (< 1 up to 120 infective bites per @entity0 per year) resulted in correspondingly large and significantly related variations in parasite prevalence (range = 38-83%). Thirty-two percent of the sites (7 of 22 sites) with @entity1 prevalences ranging from 38% to 70% had annual entomologic inoculation rates (EIR) less than five infective bites per @entity0 per year. @entity2 s.l. and An. funestus densities in Kwale were not significantly influenced by rainfall. However, both were positively correlated with rainfall one and three months previously in Malindi and Kilifi Districts, respectively. These unexpected variations in the relationship between mosquito populations and rainfall suggest environmental heterogeneity in the predominant aquatic habitats in each district. One important conclusion is that the highly non-linear relationship between EIRs and prevalence indicates that the consistent pattern of high prevalence might be governed by substantial variation in transmission intensity measured by entomologic surveys. The field-based estimate of entomologic parameters on a district level does not provide a sensitive indicator of transmission intensity in this study.

title: Spatial and temporal heterogeneity of Anopheles mosquitoes and XXXX transmission along the Kenyan coast.

answer: @entity3


abstract: BACKGROUND: Sedentary time is an independent risk factor for @entity1 and mortality. It is unknown how much time individuals with @entity4 spend being sedentary or how their sedentary time relates to markers of health. The objectives of this study were to: (a) quantify sedentary time in a post-cardiac rehabilitation (CR) population, and (b) assess association with cardiometabolic risk, independent of moderate-to-vigorous physical activity. DESIGN: Cross-sectional. METHODS: As part of a larger trial, 263 recent CR graduates (   10 days post-CR, mean age 63.6        9.3 years, 75% male) wore an ActiGraph GT3X accelerometer during waking hours (>= 4 days, >= 10 hours/day) to quantify sedentary time ( <=150 counts per minute). Spearman correlations were computed to assess relationships between sedentary time (adjusted for wear time) with markers of @entity2 and @entity3 . Significant markers were examined using multiple linear regressions. RESULTS: @entity0 spent an average of almost 8 hours/day sedentary (   14 bouts/day). Sedentary time was negatively correlated with high-density lipoprotein and [Formula: see text]O2peak and positively correlated with @entity5 , body mass index and waist circumference. After adjusting for age, sex, medications and moderate-to-vigorous physical activity, hours/day of sedentary time remained significantly associated with log[Formula: see text]O2peak (b   =   -0.02, p   =   0.003) and body mass index (b   =   0.47, p   =   0.03). CONCLUSIONS: Findings suggest that even among a group of post-CR individuals who are already probably more active than @entity0 who have not undergone CR, sedentary time remains high and is associated with poorer @entity3 , suggesting a possible new area of focus among CR programs.

title: Objectively-measured sedentary time and its association with markers of XXXX and @entity3 among cardiac rehabilitation graduates.

answer: @entity2


abstract: BACKGROUND: Laboratoires Domilens, Lyon, France, has introduced a new aspheric multifocal @entity3 ( @entity3 ), the Progress 3. The central portion, measuring 4.7 mm in diameter, has an anterior surface of progressively increasing power, such that there is a central add of +5.00 dioptres. We compared contrast sensitivity and depth of focus in @entity0 who received the Progress 3 and in those who received a conventional monofocal @entity3 . METHODS: Prospective study. Forty @entity0 with age-related @entity2 were randomly divided into two groups: 20 @entity0 received the Progress 3 aspheric multifocal @entity3 , and 20 @entity0 received a conventional monofocal @entity3 of similar design. Contrast sensitivity was measured with the Pelli-Robson letter-based chart. Depth of focus was determined by dialling a series of overcorrections over the @entity0 's manifest refraction until the @entity0 read 6/12 clearly. The depth of focus was defined as the range over which 6/12 or better acuity was achieved. @entity1 was evaluated by @entity0 questionnaire. RESULTS: Mean contrast sensitivity was significantly lower in the @entity0 with a multifocal @entity3 than in those with a monofocal @entity3 (1.38 vs. 1.56 log units) (p < 0.001). The mean depth of focus values for the two groups were 3.10 D and 1.65 D respectively (p < 0.001). The prevalence of subjective problems was similar in the two groups. INTERPRETATION: In our opinion, aspheric multifocal IOLs should be reserved for @entity0 who are willing to trade increased depth of focus for reduced contrast sensitivity postoperatively.

title: Contrast sensitivity and depth of focus with aspheric multifocal versus conventional monofocal XXXX .

answer: @entity3


abstract: PurposeCorrelate OCT-derived measures of drusen and @entity2 ( @entity2 ) @entity1 areas (RAs) with demographic features in an elderly population. @entity0 and methodsSubjects aged 50 years and older underwent Cirrus OCT scanning. Drusen area and volume were obtained from the macula within a central circle (CC) of 3   mm and a surrounding perifoveal ring (PR) of 3-5   mm, using the @entity2 analysis software (6.0). RA measurements were generated for the 6 * 6   mm(2) retinal area. Gender, age, smoking status, and systolic blood pressure (SBP) were considered.ResultsA total of 434 eyes were included. RA was larger in @entity0 (0.63  0.16 vs 0.26  0.08   mm(2), P=0.05) and with increasing age. The PR drusen area increased with increasing age (P<0.001), whereas the CC drusen area remained stable after the age of 70 years (0.25  0.06   mm(2) for ages 70-79 years and 0.25  0.07   mm(2) for ages >80 years). Drusen volume in the CC was smaller after the age of 80 years (0.009  0.003   mm(3)) compared with the 70- to 79-year-old group (0.02  0.008   mm(3)). Drusen measurements were similar between smokers and nonsmokers, but the PR drusen area (0.29   mm(2), P=0.05) and volume (0.40   mm(3), P=0.005) were correlated with years smoked. RA (0.24   mm(2), P=0.10), PR drusen area (0.29   mm(2), P=0.05), and volume (0.40   mm(3), P=0.005) were found to be directly associated with SBP. There was a high correlation between the eyes of the same subject.ConclusionOCT-based automated algorithms can be used to analyze and describe drusen and @entity3 in such population-based studies of elderly @entity0 .

title: Drusen and XXXX @entity1 automated quantification by optical coherence tomography in an elderly population.

answer: @entity2


abstract: PURPOSE OF REVIEW: To review the current status of advanced imaging techniques in identification of organ-confined @entity2 with a focus on their impact on @entity0 management. RECENT FINDINGS: Transrectal ultrasound suffers from poor accuracy despite significant technical improvements. Generally used to distinguish @entity1 with extraprostatic spread, MRI is now focusing on @entity2 identification. At 1.5T, the most recent high-resolution pelvic phased-array coils provide excellent imaging of the whole gland, including this challenging anterior part. Improvements in accuracy for @entity1 detection and volume estimation result from dynamic contrast-enhanced and diffusion-weighted imaging sequences. Histological correlations showed high sensitivity/specificity for significant @entity1 . 3T MRI scanners will improve these results. Most of the recent PET/computed tomography imaging studies use @entity3 derivatives ( @entity5 and @entity4 ). Their results are promising but insufficient to be currently recommended in routine practice. SUMMARY: Considerable advances have been made in the identification of organ-confined @entity2 with multiparametric MRI. Only prebiopsy MRI can provide best quality of @entity1 assessment and allows for targeting biopsies. It is hoped that advances in 3T MRI as well as in radiotracers for PET/computed tomography will further improve diagnosis, treatment selection, planning and outcomes.

title: Imaging of organ-confined XXXX : functional ultrasound, MRI and PET/computed tomography.

answer: @entity2


abstract: The major humoral immune responses in animals infected with @entity1 are directed toward @entity3 antigens. Among these antigens are complex-type N-glycans expressing LDN [ @entity7 -R], LDNF [ @entity8 -R], and polymeric Lewis x (Lex) [ @entity9 ]n-R epitopes. We have now evaluated the potential of the three glycan antigens as targets for immune-mediated intervention of infections and serodiagnosis. A variety of approaches were employed, including ELISA, Western blot, immunohistology, and in vitro complement lysis assays, to determine the immunogenicity of the glycans in infected @entity0 , their localization on the parasites and their efficacy as targets for parasite lysis. Our results show that @entity2 -infected @entity0 , with either @entity4 , generate predominantly IgM, but also IgG and IgA, antibodies to LDN, LDNF, and Lex. However, immune responses to Lex are generally lower than responses to LDN and LDNF and less specific to schistosome infections. Western blot analysis with monoclonal antibodies (mAb) to LDN, LDNF, and Lex determinants show that the glycan antigens occur on multiple glycoproteins from cercariae, 3-h, 48-h, and lung stage schistosomula, as well as adults and eggs. Immunohistological studies demonstrate that LDN, LDNF, and Lex are expressed on the parasite surface at all stages of development in the vertebrate host. Importantly, a mAb to LDN in the presence of complement efficiently kills schistosomula in vitro, as demonstrated by flow-cytometric assays that quantify cytolysis by @entity6 uptake into damaged parasites. These findings raise the possibility that LDN and LDNF may be targets for vaccination and/or serodiagnosis of chronic @entity5 in @entity0 .

title: Immunity to XXXX : glycans are potential antigenic targets for immune intervention.

answer: @entity5


abstract: UNASSIGNED: BACKGROUND The polymorphism of @entity3 dehydrogenase ( @entity2 ) has been reported as a risk factor for @entity0 ( @entity0 ). In the present study, we aimed to investigate whether the single-nucleotide polymorphisms (SNPs) of @entity2 gene are associated with @entity0 in a Chinese population and to determine their mechanism of action. MATERIAL AND METHODS @entity2 gene was scanned in a total of 270 @entity0 cases and 192 healthy controls by using next-generation sequencing (NGS) method. After quality control procedures, 208 selected SNP sites in @entity2 gene were enrolled for follow-up statistical association analyses. Functional analyses were also performed for significant SNPs through bioinformatics analysis. @entity1 levels of brain tissue in available @entity0 cases and healthy controls (113 and 123, respectively) were measured. Statistical and bioinformatics analyses were performed to investigate the relationship between SNPs in @entity2 and susceptibility to @entity0 . RESULTS Statistical analysis showed that 2 independent SNPs, @entity5 and @entity6 , confer the risk of @entity0 (P value=0.0195, OR (odds ratio)=1.41, 95% CI (confidence interval)=1.06-1.88; P value=0.0107, OR=0.56, 95% CI=0.36-0.87). The haplotype GGGG, which consists of 4 SNPs ( @entity4 , @entity7 , @entity8 , and @entity9 ), is also associated with risk of @entity0 (P value=0.0438, OR=0.7180, 95% CI=0.5214-0.9888). The risk allele C of @entity5 is also associated with decreased @entity1 levels in the brain (P value=0.0222, standard beta=-0.2238, 95% CI=-0.4128 - -0.0349) according to analysis in the subset of @entity0 cases and healthy controls. Bioinformatics analysis indicates that @entity5 and @entity6 are within ENCODE regulatory regions, the open chromatin regions of blastula Trophoblast cell line, and histone-marked region of brain astrocyte cell line. CONCLUSIONS The polymorphism of SNP loci @entity5 and @entity6 as well as a haplotype in @entity2 gene could serve as an indicator for the occurrence of @entity0 in Chinese population and some specific genotypes of the loci may have lower risk of developing @entity0 .

title: Polymorphisms in @entity2 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low XXXX Levels.

answer: @entity1


abstract: UNASSIGNED: Scorpion stings are a public health problem in Brazil and lactating @entity0 may be affected. We aimed to study the effects of Tityus bahiensis venom in the offspring of @entity1 treated during lactation. Mothers received a subcutaneous injection of saline (1.0ml/kg) or venom (2.5mg/kg) or an intraperitoneal injection of LPS (lipopolysaccharide) (100 g/kg) on @entity6 ( @entity6 ) days 2 (PN2), 10 (PN10) or 16 (PN16). The offspring were evaluated during the childhood and adulthood. Pups showed a delay in physical and reflexological development, and a decrease in motor activity. Adults displayed low @entity2 . There was an increase in the number of viable neuronal cells in hippocampal areas @entity3 and @entity5 . The levels of IFN-y ( @entity4 ) increased in the experimental groups. Several of the parameters analyzed showed important differences between the sexes. Thus, the scorpion venom affects the development in the offspring of mothers envenomed during the lactation.

title: Effect of maternal exposure to Tityus bahiensis scorpion venom during lactation on the offspring of XXXX .

answer: @entity1


abstract: The biological function of @entity0 ovaries declines with age. To identify the potential molecular changes in ovarian aging, we performed genome-wide gene expression analysis by microarray of ovaries from young, middle-aged, and old @entity2 . Microarray data was validated by quantitative real-time PCR. Results showed that a total of 503 (60 upregulated, 443 downregulated) and 84 (downregulated) genes were differentially expressed in old ovaries compared to young and middle-aged groups, respectively. No difference in gene expression was found between middle-aged and young groups. Differentially expressed genes were mainly enriched in cell and organelle, cellular and physiological process, binding, and catalytic activity. These genes were primarily associated with KEGG pathways of cell cycle, DNA replication and repair, oocyte meiosis and maturation, MAPK, @entity3 , and @entity4 signaling pathway. Genes upregulated were involved in aging, defense response, oxidation reduction, and negative regulation of cellular process; genes downregulated have functions in reproduction, cell cycle, DNA and RNA process, macromolecular complex assembly, and positive regulation of macromolecule metabolic process. These findings show that monkey ovary undergoes substantial change in global transcription with age. Gene expression profiles are useful in understanding the mechanisms underlying ovarian aging and age-associated @entity1 in primates.

title: Age-Specific Gene Expression Profiles of XXXX Ovaries Detected by Microarray Analysis.

answer: @entity2


abstract: UNASSIGNED: @entity2 are one of the characteristic adverse events associated with @entity5 chemotherapy. In this retrospective study, we investigated the frequency and outcome of @entity2 associated with @entity5 chemotherapy in @entity1 @entity0 . This retrospective study included 75 advanced @entity1 @entity0 who received @entity5 monotherapy between January 2014 and December 2015. We retrospectively evaluated the frequency, Grade, and @entity2 . @entity2 were observed in 16 @entity0 (21%). The median time of onset was 3(range, 1-8)months. Grade 2 @entity2 , eye discharge, and @entity3 were reported in 14, 8, and 4 @entity0 , respectively. Artificial tears, @entity4 eye-drops, and both of these treatments were used in 7, 1, and 8 @entity0 , respectively. Ophthalmologic examination was performed for 3 @entity0 . No delay or reduction of @entity5 therapy was required for the @entity2 . @entity2 associated with @entity5 therapy in @entity1 @entity0 did not affect treatment if managed properly using eye drops.

title: [Eye Disorders Associated with @entity5 Chemotherapy in XXXX @entity0 ].

answer: @entity1


abstract: BACKGROUND AND AIMS: @entity2 ( @entity2 ) have been used for the palliative treatment of malignant @entity1 ( @entity1 ). The aim of this study was to evaluate the clinical outcomes of salvage @entity2 for stent malfunction and to identify the prognostic factors for a longer patency. METHODS: A total of 108 @entity0 who underwent a secondary salvage @entity2 placement for a primary stent malfunction were retrospectively reviewed at the Seoul National University Hospital between August 2004 and May 2013. The duration of patency for salvage @entity2 was defined as the time between salvage @entity2 placement and the recurrence of obstructive symptoms that were confirmed either endoscopically or radiologically. RESULTS: The technical and clinical success rates for salvage @entity2 were 100 and 82.4  % (95  % confidence interval [CI] 74.0-89.0), respectively. A salvage @entity2 malfunction occurred in 29 (26.9  %) of the 108 @entity0 . The median duration of patency for salvage @entity2 was 59.5  days (range 3-928, 95  % CI 73.7-118.3). Longer @entity2 patencies of more than 60  days were significantly associated with palliative chemotherapy (odds ratio  =  2.539, 95  % CI 1.031-6.252, p  =  .043). For salvage @entity2 , covered-uncovered stents had a longer patency duration, as compared with other combinations of primary and salvage stent types. CONCLUSIONS: Longer patency durations for salvage @entity2 were associated with palliative chemotherapy after salvage @entity2 insertion. Salvage @entity2 could be a feasible and effective treatment for primary stent malfunction in malignant @entity1 .

title: Clinical outcomes of re-stenting in XXXX with stent malfunction in malignant @entity1 .

answer: @entity0