abstract: PURPOSE: The main objective of this study was to assess quality of life (QoL) and treatment satisfaction in a group of @entity0 with @entity2 ( @entity2 ) and explore their needs regarding and their perception of QoL living with @entity1 . MATERIALS AND METHODS: @entity0 with @entity2 attending the outpatient endocrinology clinics of a reference hospital were invited to participate in a cross-sectional study. Clinical and sociodemographic data were obtained (interview and clinical records), and @entity1 -related QoL was assessed using a standardized questionnaire. In 67 @entity0 , satisfaction with treatment was also assessed, and an open interview was performed, assessing the impact of @entity1 , long-term worries, flexibility, restrictions, and self-perception of QoL. Descriptive statistical analysis, bivariate analysis, and multivariate analysis were performed in order to find factors associated with QoL. Interviews were analyzed and summarized questionwise. RESULTS: Mean @entity0 age was 31.4  11.6 years, @entity1 duration 14.2  9.3 years, and glycated hemoglobin (HbA1c) 8.5%  1.9% (69  20.8 mmol/mol International Federation of Clinical Chemistry [IFCC]). The questionnaires showed good average QoL scores (94.6+22.9) and treatment satisfaction scores (25.7  6.7). QoL worsened with increasing HbA1c, female sex, severity of complications, and lower education (r (2)=0.283, P<0.005). In the open interview, 68.5% of the @entity0 reported that @entity1 had changed their lives, 83.5% identified complications as their most important long-term concern, and 59.7% said that they needed more training to manage the disease. CONCLUSION: Poor glycemic control, lower education, complications, and female sex are associated with worse QoL. Semi-structured interviews identified aspects not included in the standardized questionnaires.

title: Quality of life and XXXX : a study assessing @entity0 ' perceptions and self-management needs.

answer: @entity2


abstract: BACKGROUND _ AIMS: @entity0 with a first episode of @entity7 can develop recurrent or @entity10 ( @entity10 ). However, little is known about the incidence or risk factors for these events. METHODS: We performed a cross-sectional study of 669 @entity0 with a first episode of @entity7 admitted to 15 Dutch hospitals from December 2003 through March 2007. We collected information on disease course, outpatient visits, and hospital readmissions, as well as results from imaging, laboratory, and histology studies. Standardized follow-up questionnaires were sent to all available @entity0 to collect information on hospitalizations and interventions for @entity8 , @entity6 , @entity11 , @entity1 , medications, and @entity4 and @entity5 use. @entity0 were followed up for a median time period of 57 months. Primary end points were recurrent @entity9 and @entity10 . Risk factors were evaluated using regression analysis. The cumulative risk was assessed using Kaplan-Meier analysis. RESULTS: Recurrent @entity9 developed in 117 @entity0 (17%), and @entity10 occurred in 51 @entity0 (7.6%). Recurrent @entity9 developed in 12% of @entity0 with @entity3 , 24% of @entity0 with alcoholic etiology, and 25% of @entity0 with disease of idiopathic or other etiologies; @entity10 occurred in 3%, 16%, and 10% of these @entity0 , respectively. Etiology, smoking, and necrotizing @entity9 were independent risk factors for recurrent @entity9 and @entity10 . Acute Physiology and Chronic Health Evaluation II scores at admission also were associated independently with recurrent @entity9 . The cumulative risk for recurrent @entity9 over 5 years was highest among smokers at 40% (compared with 13% for nonsmokers). For @entity4 abusers and current smokers, the cumulative risks for @entity10 were similar-approximately 18%. In contrast, the cumulative risk of @entity10 increased to 30% in @entity0 who smoked and abused @entity4 . CONCLUSIONS: Based on a retrospective analysis of @entity0 admitted to Dutch hospitals, a first episode of @entity7 leads to recurrent @entity9 in 17% of @entity0 , and almost 8% of @entity0 progress to @entity10 within 5 years. Progression was associated independently with alcoholic etiology, smoking, and a history of @entity2 . Smoking is the predominant risk factor for recurrent disease, whereas the combination of @entity4 abuse and smoking produces the highest cumulative risk for @entity10 .

title: Risk of Recurrent @entity9 and @entity10 After a First Episode of Acute XXXX .

answer: @entity9


abstract: PURPOSE: @entity14 ( @entity14 , Incel) restores drug sensitivity to cells expressing @entity9 ( @entity15 ). @entity13 is expressed in a high proportion of @entity5 while @entity9 expression is variable. Since @entity12 (M) and @entity3 (P) are substrates for MDR transporters, we initiated a study to evaluate the safety, pharmacokinetics, and efficacy of @entity14 plus M/P in @entity0 with @entity5 ( @entity5 ). @entity0 AND METHODS: Eligible @entity0 had progressive @entity5 (defined as new lesions, new disease-related @entity2 , or 50% increase in PSA within 6 weeks of entry), @entity4 <30 ng/ml, no prior chemotherapy, ECOG performance status of 0-3, and adequate organ function. @entity0 received @entity14 (120 mg/m(2) per h) as a 72-h continuous intravenous infusion with intravenous bolus @entity12 (12 mg/m(2)) administered 4 h after @entity14 was started and @entity3 (5 mg twice daily) administered throughout the study treatment. Endpoints included serum PSA response, PSA response duration, time to PSA progression, @entity2 reduction, and quality of life measures. RESULTS: Enrolled in the study were 40 @entity0 and 184 courses of @entity14 plus M/P were administered. Intensive pharmacokinetics, which were performed on six @entity0 who received one cycle of M/P alone, followed by @entity14 plus M/P for all other cycles, showed that @entity14 did not alter @entity12 clearance. @entity14 blood concentration at the time of @entity12 administration averaged 4.52 microg/ml. @entity14 plus M/P was well tolerated. @entity8 and mild @entity10 were the principal treatment @entity1 . Five @entity0 experienced an uncomplicated febrile neutropenic episode (12%), three had severe @entity6 / @entity7 , and two experienced transient moderate to severe @entity11 . Of the 40 @entity0 , 12 (30%, 95% confidence interval 16-44%) had a reduction in PSA of >/=50% and 9 of the 12 @entity0 (23% overall, 95% CI 10-35%) achieved a reduction in PSA of >/=80% that was sustained for the duration of treatment with M/P plus @entity14 . The median time to PSA progression was 41 weeks (95% CI 34-68 weeks). Of the 40 @entity0 , 15 completed treatment with stable disease and 13 had progressive disease with increasing serum PSA during study treatment. Median survival was 48 weeks for the intent-to-treat population of 40 @entity0 . CONCLUSIONS: The addition of @entity14 to M/P therapy did not appear to increase the proportion of @entity0 with significant serum PSA reductions compared to M/P alone. However, the duration of PSA response observed for the 12 PSA responders suggests that MDR inhibition may benefit some @entity0 with @entity5 . In addition to @entity13 or @entity9 expression, other mechanisms of drug resistance are probably associated with the relative insensitivity of @entity5 to cytotoxic therapy.

title: Safety and efficacy of the MDR inhibitor Incel (biricodar, @entity14 ) in combination with @entity12 and XXXX in @entity5 .

answer: @entity3


abstract: Selecting the proper treatment strategy for locally advanced @entity1 , such as @entity2 , is difficult. Therefore, obtaining an accurate diagnosis of @entity2 is required. It can be difficult to determine whether the @entity2 invades adjacent structures. We describe the case of a @entity0 easily diagnosed to be without aortic invasion using cine magnetic resonance imaging (MRI). We herein report the case of an 80-year-old male who presented a @entity1 . The transbronchial lung washing cytology findings were consistent with those of @entity3 . In addition, the computed tomography findings indicated suspected aortic invasion of the @entity1 , as the mass girdled the descending aorta beyond 120   adjoining at a length of 10 cm. However, cine MRI display clearly demonstrated a clear area of isolation between the aorta and lung tissue based on differences in the heart rhythm from the @entity0 's @entity5 . Therefore, the lesion was clinically diagnosed as a stage IIB (T3N0M0) @entity2 . Radiation was administered due to the @entity0 's advanced age and comorbidities such as @entity4 . He remains alive without disease progression 6 months after the therapy. Our findings, therefore, indicate the usefulness of easily diagnosing the absence of aortic invasion in @entity0 with @entity1 using cine MRI without the need for a special software program.

title: Easy Diagnosis of Aortic Invasion in XXXX with @entity1 Using Cine Magnetic Resonance Imaging.

answer: @entity0


abstract: PURPOSE: To report the efficacy of an aggressive systematic regimen for the treatment of acute @entity5 ( @entity5 ). METHODS: Eleven @entity0 who had unilateral @entity5 with symptoms of fewer than 48 hours' duration were treated with an aggressive stepwise systematic regimen until retinal circulation improved or until all the treatment steps were performed. Five @entity0 with unilateral @entity5 and symptoms of fewer than 48 hours' duration were treated in the same institution in an arbitrary nonsystematic manner. The therapeutic steps of the aggressive treatment included ocular massage, sublingual @entity11 , intravenous @entity12 , intravenous @entity10 or oral @entity3 , anterior chamber paracentesis, intravenous @entity6 followed by streptokinase, and retrobulbar @entity13 . After each step, retinal flow was evaluated by three-mirror contact lens. The nonsystematic treatment was arbitrary and included one or several of the above. Visual acuity and complete eye examination data were recorded before and after treatment. RESULTS: Visual acuity and retinal arterial supply were improved in eight (73%) of the 11 @entity0 treated in the stepwise systematic manner. All eight @entity0 in whom visual acuity improved had symptoms for fewer than 12 hours, and the presumed cause was either platelet-derived or @entity1 embolus from @entity8 or the @entity0 had @entity4 . @entity0 in whom visual acuity did not improve had @entity5 that was attributed to calcified emboli or primary @entity7 and had symptoms more than 12 hours before treatment. Visual acuity did not improve in all five @entity0 with the nonsystematic treatment regardless of the presumed cause or duration of the occlusion. The success of the treatment in the systematic treatment group was statistically significantly better compared with the outcome of the nonsystematic treated group (Fischer exact test, P = .01). CONCLUSIONS: In the treatment of @entity5 , an aggressive systematic regimen including medical and mechanical means may reestablish retinal circulation and improve visual outcome. The cause of @entity2 , the nature of occlusive emboli, and the duration of @entity9 may determine the visual outcome, but a larger series is warranted to verify the effectiveness of the treatment and the prognostic factors.

title: Aggressive systematic treatment for XXXX .

answer: @entity5


abstract: Necrotic insults such as @entity1 are excitotoxic. Logically, membrane hyperpolarization by increasing outwardly conducting @entity4 channel currents should attenuate hyperexcitation and enhance neuron survival. Therefore, we overexpressed a small-conductance @entity2 -activated ( @entity10 ) or voltage-gated ( @entity8 ) channel via viral vectors in cultured hippocampal neurons. We found that @entity10 or @entity8 protected not only against @entity7 or @entity6 excitotoxicity but also increased survival after @entity9 or @entity3 . In vivo overexpression of either channel in dentate gyrus reduced @entity7 -induced @entity5 lesions. In hippocampal slices, the @entity7 -induced increase in granule cell excitability was reduced by overexpression of either channel, suggesting that these channels exert their protective effects during hyperexcitation. It is also important to understand any functional disturbances created by transgene overexpression alone. In the absence of insult, overexpression of @entity8 , but not @entity10 , reduced baseline excitability in dentate gyrus granule cells. Furthermore, while no behavioral disturbances during spatial acquisition in the Morris water maze were observed with overexpression of either channel, animals overexpressing @entity10 , but not @entity8 , exhibited a memory deficit post-training. This difference raises the possibility that the means by which these channel subtypes protect may differ. With further development, @entity4 channel vectors may be an effective pre-emptive strategy against @entity0 .

title: XXXX channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults.

answer: @entity4


abstract: OBJECTIVE: To compare the value of the myocardial perfusion imaging with 99Tc sestamibi (MIBI) with clinical data and stress EKG (SEKG) variables, in the detection of @entity4 ( @entity4 : lesion > 50%), in a group of @entity0 (pts) with @entity2 ( @entity3 above 70% in one epicardial artery), submitted to coronary angioplasty (PTCA) with stenting. POPULATION AND METHODS: Fifty-nine pts, followed prospectively, (49 males and 10 females aged 57 +/- 10) were submitted to 61 angioplasties, with dilatation of 59 vessels, and with stenting in 63 (1.07 stent/vessel). Clinical evaluation was performed in the first, third and sixth month, SEKG with MIBI in the fourth month and recatheterization for angiographic control in the sixth month. The pts were divided in two groups: R-positive @entity4 ( @entity4 )--14 pts: NR--without @entity4 --45 pts; the @entity4 rate was 23.7%. The @entity0 ' history, cause of admission, procedure characteristics, medication at discharge, clinical events during follow-up, variables of stress EKG associated with myocardial perfusion and angiographic control were analyzed. RESULTS: The cause of admission was the same in both groups (MI in R group: 28.6%; NR: 46.7%; p = ns). There was no difference in the discharge medication. The R group was more symptomatic (Angina: R = 50.0% vs NR = 11.1%; p < 0.001 clinical restenosis rate = 11.8%), and had more revascularization procedures (PTCA: R = 57.1% vs NR = 2.8%; p < 0.001/Bypass surgery: R = 14.3% vs NR = 0%; p = 0.01). This group had abnormal stress EKG more frequently (42.9 vs 20.0%, p = ns) and @entity1 in the myocardial perfusion scintigraphy (57.1 vs 6.7% p < 0.001). [table: see text] CONCLUSION: The clinical and diagnostic tests evaluated in this study showed a limited sensitivity in the detection of @entity4 in a group of @entity0 with @entity2 submitted to coronary angioplasty and stenting. @entity5 was the best method for the detection of @entity4 , showing a high specificity and a reasonable sensitivity.

title: [Angioplasty with stenting in XXXX : non invasive methods for detecting restenosis].

answer: @entity2


abstract: The purpose of this study was to describe acute @entity2 as a new @entity3 associated with @entity10 , when it is delivered at high doses (> or =600 mg/m2) with stem cell support. A total of 129 @entity0 , included in clinical trials of @entity10 -containing high-dose chemotherapy, were analyzed. A total of 114 @entity0 received @entity10 at a dose of > or =600 mg/m2. Six @entity0 presented acute @entity2 starting between 7 and 23 days after @entity10 treatment; two of them had received prior whole-brain irradiation. @entity10 was given alone (one @entity0 ), with @entity7 and @entity8 (two @entity0 ), and with @entity7 and @entity8 plus @entity11 (three @entity0 ). @entity4 consisted of rapid obtundation and @entity6 (five @entity0 ) and severe confusional picture with @entity12 (one @entity0 ). Brain magnetic resonance imaging showed diffuse @entity1 (one @entity0 ) or multiple small @entity9 (one @entity0 ), or it was normal (four @entity0 ). Other complementary tests, including cerebrospinal fluid analysis and electroencephalography, were nondiagnostic. An effect from concomitant psychotropic medications or from other organ toxicities was excluded in all @entity0 . Three @entity0 recovered after 8-15 days, either spontaneously (two @entity0 ) or after high-dose @entity5 (one @entity0 ). Three @entity0 died of irreversible @entity6 . Necropsy, performed in two @entity0 , showed generalized @entity1 and multiple brain parenchymal @entity9 , respectively. No pharmacodynamic correlation between the occurrence of @entity2 and a pharmacokinetic parameter of @entity10 could be identified. @entity10 -containing high-dose chemotherapy can cause severe acute @entity2 . An aggravating effect from prior brain irradiation or concurrent @entity11 seems possible.

title: Acute @entity2 : a new @entity3 associated with high-dose XXXX .

answer: @entity10


abstract: @entity8 ( @entity8 ) signaling has been shown to have antipsychotic properties in animal models and to impact @entity1 -dependent insulin release, satiety, memory, and learning in @entity0 . Previous work has shown that two coding mutations ( @entity10 and @entity11 ) are associated with altered insulin release and @entity2 levels. We identified four frequently occurring haplotypes in Caucasians, haplotype 1 through haplotype 4, spanning exons 4-7 and containing the two coding variants. We analyzed response to antipsychotics, defined as predicted change in PANSS-Total (dPANSS) at 18months, in Caucasian subjects from the Clinical Antipsychotic Trial of Intervention Effectiveness treated with @entity4 (n=139), @entity9 (n=78), @entity5 (n=14), @entity6 (n=143), and @entity7 (n=90). Haplotype trend regression analysis revealed significant associations with dPANSS for @entity4 (best p=0.002), @entity9 (best p=0.01), @entity5 (best p=0.008), @entity6 (best p=0.02), and @entity7 (best p=0.007). We also evaluated genetic models for the two most common haplotypes. Haplotype 1 (uniquely including the @entity11 [Leu(260)] allele) was associated with better response to @entity4 (p=0.002), and @entity6 (p=0.006), and worse response to @entity9 (p=.03), and @entity7 (p=0.003), with a recessive genetic model providing the best fit. Haplotype 2 (uniquely including the @entity10 [Ser(168)] allele) was associated with better response to @entity9 (p=0.001) and worse response to @entity4 (p=.02), with a dominant genetic model providing the best fit. However, @entity8 haplotypes were not associated with antipsychotic-induced @entity3 . These results link functional genetic variants in @entity8 to antipsychotic response.

title: XXXX ( @entity8 ) haplotypes correlate with altered response to multiple antipsychotics in the CATIE trial.

answer: @entity8


abstract: BACKGROUND: The National Kidney Foundation has recommended that the @entity10 Epidemiology Collaboration (CKD-EPI) equation replace the @entity2 ( @entity2 ) Study equation. Before implementing this change in the Kidney Early Evaluation Program (KEEP), we compared characteristics of reclassified individuals and mortality risk predictions using the new equation. METHODS: Of 123,704 eligible KEEP @entity0 , 116,321 with data available for this analysis were included. Glomerular filtration rate (GFR) was estimated using the @entity2 Study ( @entity8 ( @entity2 )) and CKD-EPI ( @entity8 ) equations with @entity12 level calibrated to standardized methods. @entity0 were characterized by @entity8 category: >120, 90-119, 60-89, 45-59, 30-44, and <30 mL/ @entity11 .73 m(2). Clinical characteristics ascertained included age, race, sex, @entity1 , @entity4 , @entity7 , @entity9 , @entity3 , @entity13 , and @entity6 . Mortality was determined over a median of 3.7 years of follow-up. RESULTS: The prevalence of @entity8 .73 m(2) was 14.3% compared with 16.8% using @entity8 ( @entity2 ). Using @entity8 (CKD-EPI), 20,355 @entity0 (17.5%) were reclassified to higher @entity8 categories, and 3,107 (2.7%), to lower categories. @entity0 reclassified upward were younger and less likely to have chronic conditions, with a lower risk of mortality. A total of 3,601 deaths (3.1%) were reported. Compared with @entity0 classified to @entity8 of 45-59 mL/ @entity11 .73 m(2) using both equations, those with @entity8 .73 m(2) had a lower mortality incidence rate (6.4 [95% CI, 5.1-7.7] vs 18.5 [95% CI, 17.1-19.9]). Results were similar for all @entity8 categories. Net reclassification improvement was 0.159 (P < 0.001). CONCLUSIONS: The CKD-EPI equation reclassifies @entity0 at lower risk of CKD and @entity5 into higher @entity8 categories, suggesting more accurate categorization. The CKD-EPI equation will be used to report @entity8 in KEEP.

title: Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and XXXX ( @entity2 ) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP).

answer: @entity2


abstract: Antiplatelet drugs have been shown to prevent a range of atherothrombotic events, including @entity14 ( @entity14 ) and @entity1 . @entity11 and @entity10 are @entity8 ( @entity8 )-receptor antagonists that inhibit @entity8 -induced fibrinogen binding to platelets, a necessary step in the @entity12 process. The Antithrombotic Trialists' Collaboration recently published a major meta-analysis that assessed the effect of antiplatelet therapy in @entity0 with various manifestations of @entity7 . In total, this analysis included 135,000 @entity0 in comparisons of antiplatelet agents versus control and 77,000 @entity0 in comparisons of different antiplatelet regimens. This meta-analysis found that overall, antiplatelet therapy reduces the combined odds of @entity1 , @entity6 ( @entity6 ) or @entity5 by 22%, and that antiplatelet agents reduce the odds of a non-fatal @entity1 by 25% over a wide range of @entity0 with or without a history of @entity3 . In the CAPRIE trial of @entity11 versus @entity4 ( @entity9 ), there was a 10% odds reduction for @entity1 , @entity6 in favour of @entity11 (p = 0.03). In a meta-analysis performed by the Cochrane @entity1 Group, @entity8 -receptor antagonist therapy significantly reduced the odds of a serious vascular event ( @entity1 , @entity6 ) by 9% (2p = 0.01) and of any @entity1 by 12%. The safety/tolerability profile of @entity11 was superior to that of @entity10 , and at least as good as that of @entity9 . In CURE, a long-term benefit was observed with the use of @entity11 on top of standard therapy (including @entity9 in all @entity0 ), with a 20% relative risk reduction for the primary endpoint of @entity2 , @entity6 or @entity1 (p < 0.001) in @entity0 with @entity13 and non-Q-wave @entity6 . A consistent benefit was seen across all @entity0 subgroups, including @entity0 with a previous history of @entity1 . More recently, CREDO has demonstrated the incremental benefit of prolonged use of @entity11 on top of @entity9 in @entity0 undergoing elective PCI, with a 27% reduction in the combined risk of @entity5 , @entity6 or @entity1 after 12 months of therapy (p = 0.02) and a 25% reduction in @entity1 over the same time period. The MATCH trial is currently being conducted to test the hypothesis that long-term administration of @entity11 on top of @entity9 is superior to @entity11 alone for the reduction of major ischaemic events in @entity0 with recent @entity14 or @entity1 who are at high risk of atherothrombotic recurrence. Further trials of @entity11 on top of standard therapy (including @entity9 ) are planned in neurology; these include SPS3, in @entity0 with small subcortical @entity1 , and ATARI, in @entity0 who have recently recovered from a @entity14 .

title: Evidence with antiplatelet therapy and XXXX -receptor antagonists.

answer: @entity8


abstract: It has been shown that high levels of high-density lipoprotein (HDL) @entity1 and low levels of low-density lipoprotein (LDL) @entity1 are associated with health maintenance in older @entity0 , but the few studies that have examined the relationship between exercise and plasma lipoprotein levels in this elderly population have been equivocal. In addition, there are no studies that examine the plasma lipoprotein response of two different types of exercise in a group of active but nonexercising @entity0 . Thus, the effects of exercise training on plasma lipoprotein levels in elderly @entity0 remain unclear. The purpose of this research was to examine the effects of endurance and resistance exercise on plasma lipoprotein levels in elderly @entity0 who were active but nonexercising prior to the study. A total of 45 healthy, active @entity0 , aged 70-87 years, were randomly assigned to either an @entity2 ( @entity2 , 76 +/- 5 years, n = 15), @entity4 ( @entity4 , 73 +/- 3 years, n = 15), or control (C, 74 +/- 5 years, n = 15) group. The @entity2 group walked 3 days a week at 70% heart rate reserve. The duration on day 1 was 20 minutes, and it was increased by 5 minutes each day until subjects were walking for 50 minutes (week 3). The exercise training session for the @entity4 group consisted of one to three sets of eight repetitions of eight different exercises at an eight repetition maximum; the C group maintained normal activity. Weight and diet were unchanged across groups. The exercise interventions lasted 10 weeks. Blood samples were obtained from all subjects at week 0 and week 11. Training resulted in a significant decrease in 1-mile walk times and heart rate at completion of the walk for the @entity2 group and a significant increase in eight repetition maximum of all @entity4 exercises. Both @entity2 and @entity4 groups experienced increased HDL @entity1 and decreased triglycerides at week 11 compared with week 0. There were no positive changes in control lipoproteins. Both @entity3 and the total @entity1 to HDL ratio increased significantly while total @entity1 , HDL @entity1 , and LDL @entity1 remained unchanged. The @entity4 group also had significantly lower LDL @entity1 and total @entity1 compared with controls at week 11. Both @entity4 and endurance training resulted in favorable changes to plasma lipoprotein levels for elderly @entity0 in only 10 weeks. The fact that this occurred without concurrent changes in weight or diet is an indication that high-intensity exercise alone can be used to modify lipoproteins in populations of healthy elderly @entity0 .

title: Effects of endurance training and XXXX on plasma lipoprotein profiles in elderly @entity0 .

answer: @entity4


abstract: BACKGROUND: Faecalibacterium prausnitzii comprises 2 phylogroups, whose abundance in healthy and diseased gut and in conjunction with @entity5 has not yet been studied. This work aims to determine the contribution of F. prausnitzii phylogroups I and II in @entity8 and to assess their potential diagnostic usefulness as biomarkers for gut diseases. METHODS: Total F. prausnitzii, its phylogroups, and @entity5 loads were determined by quantitative polymerase chain reaction targeting the 16S rRNA gene on biopsies from 31 healthy controls (H), 45 @entity0 with @entity3 ( @entity3 ), 25 @entity0 with @entity4 , 10 @entity0 with @entity7 , and 20 @entity0 with @entity1 . Data were normalized to total bacterial counts and analyzed according to @entity0 ' disease location and clinical characteristics. RESULTS: Lower levels of both total F. prausnitzii and phylogroup I were found in subjects with @entity3 , @entity4 , and @entity1 (P < 0.001) compared with H subjects. Phylogroup I load was a better biomarker than total F. prausnitzii to discriminate subjects with gut disorders from H. Phylogroup II depletion was observed only in @entity0 with @entity3 (P < 0.001) and can be potentially applied to differentiate @entity6 from @entity3 . No statistically significant correlation between @entity5 and any of the 2 F. prausnitzii phylogroups was found in any group of @entity0 or by @entity2 location. Phylogroup I was lower in active @entity0 with @entity3 , whereas those @entity3 with intestinal resection showed a reduction in phylogroup II. Treatments with @entity9 and immunosuppressants did not result in the recovery of F. prausnitzii phylogroups abundance. CONCLUSIONS: F. prausnitzii phylogroup I was depleted in @entity3 , @entity4 , and @entity1 , whereas phylogroup II was specifically reduced in @entity3 . Quantification of F. prausnitzii phylogroups and @entity5 may help to identify gut disorders and to classify @entity2 location.

title: Changes in the Abundance of Faecalibacterium prausnitzii Phylogroups I and II in the Intestinal Mucosa of XXXX and @entity0 with @entity1 .

answer: @entity2


abstract: BACKGROUND: A considerable number of @entity0 suffer delayed @entity3 even after a successful removal of @entity8 . The underlying pathology remains unknown. Radiological findings could be an explanation for poor outcome after surgery. METHODS: We conducted a retrospective study of all cases treated from 1980 to 2016 in our department. Included were all @entity0 with @entity8 treated with microsurgical excision. The cross-sectional area (CSA) of the spinal cord at the level of the former performed surgery was compared in MRI scans with follow up MRI scans, adjacent not affected levels and with control group. RESULTS: 54 @entity0 with an intramedullary spinal cord lesion were treated in this period. @entity4 was the predominant @entity1 (28) followed by @entity2 and @entity5 . Mean age was 48.2    10.5 years with a female predominance (f=16, m=12). An unfavorable outcome was observed in 53% of the @entity0 after an initially uneventful postoperative course. The follow up cross-sectional area of the spinal cord was significantly reduced in these @entity0 compared to adjacent not operated levels and control group. Sagittal and axial spinal MRI showed spinal cord narrowing due to @entity7 in the area of the performed surgery in 53 % of @entity0 with @entity4 after a mean follow-up time of 9 years. Functional outcome in @entity4 was significantly associated with @entity6 (p< 0.05). CONCLUSIONS: @entity6 seems to be a predicting factor in long term outcome after surgical removal of @entity8 .

title: Regional @entity6 is associated with poor outcome after surgery on XXXX : a new aspect of delayed neurological deterioration.

answer: @entity8


abstract: During the perioperative period, gastric emptying rate and first-pass metabolism limit the use of peroral @entity0 . Buccal mucosa appears to be a potential site for delivery of @entity0 as it provides direct entry into the system circulation thereby avoiding the hepatic first-pass effect. However, the low permeability of the buccal epithelium results in a low flux of the drug. The use of a penetration enhancer is required to improve the bioavailability of the drug via buccal route. In this study, the enhancing effect of @entity2 (GC) used at 10 mM and 100 mM concentrations on permeation of @entity3 ( @entity1 ) across the porcine buccal mucosa was studied in vitro. Furthermore, in conjunction with its permeation, accumulation of GC in the tissue with time was also studied in order to elucidate the relationship between GC and enhanced mucosal permeation of the drug. Franz diffusion cells were used in the experiments. Permeation of @entity1 was increased in the presence of 100 mM GC with an enhancement factor of 9.3 whereas no enhancement was obtained with 10 mM GC. The calculated permeability coefficient for @entity1 in the presence of 100 mM GC was 2.35 x 10(-5) cm/s. Accumulation of GC at 100 mM in the tissue appears to be more significant at 100 mM concentration which correlated well with the increased permeation of the drug. GC was diffused through the buccal epithelium significantly at 100 mM concentration. Interaction of GC with the tissue appears to be more significant at 100 mM concentration compared to 10 mM concentration, thus resulting in a significant enhancing effect.

title: In vitro studies on enhancing effect of @entity2 on transbuccal permeation of XXXX .

answer: @entity3


abstract: OBJECTIVE: To examine the prevalence of @entity2 in @entity1 ( @entity1 ) in the outpatient setting and to determine what assessment criteria to use to select @entity0 with @entity2 for referral to speech and language therapists. MATERIAL AND METHODS: Sixty-four @entity0 with @entity1 and 80 age-matched controls were interviewed in clinic about their swallowing history and an objective swallowing test administered. All @entity0 were assessed over the next few weeks by an experienced speech and language therapist and @entity2 rated according to a modified Rehabilitation Institute of Chicago @entity2 Rating Scale and a novel global rating scale. The ability of various clinic criteria to predict @entity0 with severe @entity2 were examined. RESULTS: @entity2 for food was found in 30% of @entity0 , significantly more than in controls. Swallowing speed and bolus volume were significantly lower in @entity0 compared with controls and were correlated with declining Hoehn and Yahr score. Swallowing speed fell significantly on withdrawal of medication. The therapist's global rating score and Chicago score declined with Hoehn and Yahr score and duration of disease. However, only 10% of @entity0 required dietary advice and none needed gastrostomy or tracheostomy. Discriminant analysis showed that various combinations of clinic selection criteria were no better than the presence of @entity2 for food at predicting which @entity0 had significant @entity2 requiring advice from a therapist. CONCLUSIONS: @entity0 with @entity1 should be questioned about @entity2 for food on a regular basis and, if present, should be referred to a speech and language therapist for further assessment and treatment. The outcome of this protocol should be tested prospectively.

title: Referral criteria for speech and language therapy assessment of @entity2 caused by XXXX .

answer: @entity1


abstract: OBJECTIVE: The aortic distensibility index, as a measure of vascular function, can serve as a marker of @entity1 severity. This study explores the feasibility of using the non-invasively measured index as an indicator of severity of @entity4 . METHODS: One hundred @entity0 with normal left ventricular systolic function were prospectively enrolled. They were subjected to assessment of aortic distensibility using computed tomographic angiography and transthoracic echocardiography. @entity1 severity and coronary artery @entity2 score were assessed. RESULTS: The mean age of the whole study cohort was 58 +/- 9 years, 63 (63%) being males. A significant inverse correlation was found between aortic distensibility measured using computed tomographic angiography and @entity0 ' age, systolic blood pressure, coronary artery @entity2 score and severity of @entity1 ( @entity3 ). However, there was no statistical correlation with the number of diseased coronary arteries. A strong direct correlation was recorded upon comparing aortic distensibility index values obtained using computed tomographic angiography and transthoracic echocardiography (r=0.325, P=0.004). Receiver operating characteristic curve analysis revealed that an echocardiography-derived aortic distensibility index value of 6.65% is associated with significant (50% luminal stenosis) @entity1 with a sensitivity of 83%, specificity of 93%, positive predictive value of 97% and negative predictive value of 65%. CONCLUSION: Non-invasive assessment of aortic distensibility indices is a feasible procedure to predict significant @entity1 . Lower values are associated with significant obstructive @entity1 and high coronary artery @entity2 score.

title: Using aortic distensibility index to detect XXXX .

answer: @entity4


abstract: PURPOSE: To investigate @entity1 reperfusion injury (IRI) using diffusion tensor imaging (DTI). MATERIALS AND METHODS: Ten @entity0 were scanned at 7 Tesla (T) with DTI using b-value of 1000 s/mm(2) and 6 gradient directions before, 2 h, and 1 day after 30-min total hepatic IRI. Apparent diffusion coefficient or @entity2 ( @entity2 ), directional diffusivities and fractional anisotropy (FA) were measured. Seven of the animals were also examined with spin-echo echo-planar diffusion-weighted imaging (DWI) with seven b-values up to 2000 s/mm(2) to estimate the true diffusion coefficient (D), blood pseudodiffusion coefficient (D), and perfusion fraction (f) using a bi-compartmental model. RESULTS: @entity2 2 h after IRI (0.77 +/- 0.07 x 10(-3) mm(2)/s) was significantly lower (P < 0.01) than that before (1.03 +/- 0.07 x 10(-3) mm(2)/s) and 1 day after IRI (1.01 +/- 0.05 x 10(-3) mm(2)/s). Meanwhile, @entity3 after IRI (0.33 +/- 0.03) was significantly higher (P < 0.01) than that before (0.21 +/- 0.02) and 1 day after IRI (0.20 +/- 0.02). The bi-compartmental model analysis revealed the transient decrease in D, D and f 2 h after IRI. Liver histology showed the multifocal cell swelling 3 h after IRI and widespread cell necrosis/apoptosis 1 day after IRI. Sinusoidal narrowing and congestion of erythrocytes were also observed 3 h and 1 day after IRI. CONCLUSION: DTI can characterize hepatic IRI by detecting the transient change in both @entity2 and FA.

title: In vivo DTI assessment of XXXX reperfusion injury in an experimental @entity0 model.

answer: @entity1


abstract: It is still enigmatic under which circumstances cellular demise induces an immune response or rather remains immunologically silent. Moreover, the question remains open under which circumstances apoptotic, autophagic or @entity1 cells are immunogenic or tolerogenic. Although apoptosis appears to be morphologically homogenous, recent evidence suggests that the pre-apoptotic surface-exposure of @entity5 may dictate the immune response to @entity0 cells that succumb to anticancer treatments. Moreover, the release of @entity3 ( @entity3 ) during late apoptosis and secondary @entity1 contributes to efficient antigen presentation and cytotoxic T-cell activation because @entity3 can bind to @entity4 on dendritic cells, thereby stimulating optimal antigen processing. Cell @entity2 accompanied by autophagy also may facilitate cross priming events. Apoptosis, @entity1 and autophagy are closely intertwined processes. Often, cells manifest autophagy before they undergo apoptosis or @entity1 , and apoptosis is generally followed by secondary @entity1 . Whereas apoptosis and @entity1 irreversibly lead to cell @entity2 , autophagy can clear cells from stress factors and thus facilitate cellular survival. We surmise that the response to cellular stress like chemotherapy or ionizing irradiation, dictates the immunological response to dying cells and that this immune response in turn determines the clinical outcome of anticancer therapies. The purpose of this review is to summarize recent insights into the immunogenicity of dying @entity0 cells as a function of the cell @entity2 modality.

title: Immunogenic cell @entity2 modalities and their impact on XXXX treatment.

answer: @entity0


abstract: We aimed to detect new cases of konzo and monitor cyanogen exposure from @entity0 flour in communities previously affected by konzo epidemics in Nampula Province, northern Mozambique. Other objectives were to detect subclinical upper motor neuron damage in schoolchildren and test a new kit to measure urinary @entity1 concentration. In 1999 and 2000, we carried out active and passive case detection for konzo in Memba and Mogincual Districts. In July and October, 1999, we collected @entity0 flour from 30 houses in three communities and measured cyanogen concentrations with a picrate kit. In October 1999, we examined all schoolchildren in three communities for ankle clonus and measured urinary @entity1 concentration in thirty schoolchildren in each of five communities with a picrate kit. We found 27 new cases of konzo in Mogincual District. Mean total cyanogen concentrations in @entity0 flour varied between both seasons and years, but were always high, ranging from 26 to 186 ppm. Very high mean levels at three sites in November 1998 and July 1999 were probably due to low rainfall in the 1997-1998 season. The proportion of schoolchildren with ankle clonus varied from 8 to 17%. The new picrate kit for urinary @entity1 worked well; mean concentrations in schoolchildren ranged from 225 to 384 micromol x l(-1). Konzo and sub-clinical upper motor neuron damage persist in poor rural communities in northern Mozambique, associated with high cyanogen concentrations in @entity0 flour and high urinary @entity1 concentrations in schoolchildren.

title: Persistent konzo and cyanogen toxicity from XXXX in northern Mozambique.

answer: @entity0


abstract: OBJECTIVE: @entity2 ( @entity2 ) is the most common @entity4 , progressing in approximately 10% of cases toward chronic venous leg @entity5 , whereas the @entity8 gene ( @entity10 ) @entity11 mutation is the most common recognized genetic defect in @entity1 metabolism. Because @entity2 leads to local @entity1 overload in the affected legs, we investigated whether two common @entity10 mutations could increase the risk of chronic venous leg @entity5 . METHODS: This was a case-control study at the @entity4 Center, University of Ferrara, Italy. From a cohort of 980 consecutive @entity0 affected by severe @entity2 (CEAP clinical classes C4 to C6) we selected 238 cases with the exclusion of any other comorbidity factor potentially involved in wound etiology (group A). They were subdivided into group B, including 137 @entity0 with @entity5 (classes C5 and C6: 98 primary and 39 postthrombotic cases), and group C, including 101 cases with no @entity3 (class C4). They were completely matched for sex, age, and geographic origin with 280 healthy controls (group D). A total of 518 subjects were polymerase chain reaction genotyped for @entity10 mutations ( @entity11 and @entity9 ). We assessed the risk of @entity5 by comparing the prevalence of @entity5 in homogenous cases with and without the @entity10 variants. Other main outcome measures were the sensitivity, specificity, and predictive values of the genetic test in @entity2 cases. RESULTS: @entity11 mutation significantly increases the risk of @entity5 in primary @entity2 by almost seven times (odds ratio, 6.69; 95% confidence interval, 1.45-30.8; P = .01). Application of the @entity10 test in primary @entity2 demonstrated increased specificity and positive predictive values (98% and 86%, respectively), with negligible sensitivity and negative predictive values. CONCLUSIONS: The overlap of primary @entity2 and the @entity11 mutation consistently increases the risk of developing venous leg @entity5 . These data, which have been confirmed in other clinical settings, suggest new strategies for preventing and treating primary @entity2 . CLINICAL RELEVANCE: The number of @entity0 affected by primary @entity2 is so great that the vast majority of @entity5 are also related to this common problem. On the other hand, there is not a reliable way for identifying in advance, from the broad base of primary @entity2 @entity0 (20-40% of the general population), the high risk minority (10% of primary @entity2 cases) who will develop a @entity6 . In such cases, a simple @entity11 blood genetic test demonstrated an elevated specificity in predicting @entity5 development (98%, CI 95%, 92.8-99.7). The genetic test could be applied starting from the C2 class, varicose veins, the most common situation observed in clinical practice. In perspective, the presence of the @entity11 mutation would strengthen the indications and priorities for surgical correction of superficial @entity7 .

title: @entity8 @entity11 gene mutation increases the risk of venous leg XXXX .

answer: @entity5


abstract: UNASSIGNED: Background The prevalence of antimicrobial co-resistance among ESBL-producing Enterobactereaceae is extremely high in Israel. Multidrug-resistant @entity4 strains (MDR-PM), resistant to almost all antibiotic classes have been described. The aim was to determine the risk factors for @entity1 caused by MDR-PM and clinical outcomes. Methods A retrospective case-control study. Adult @entity0 with PM @entity3 during 7 years were identified retrospectively and their files reviewed for demographics, underlying diseases, Charlson Comorbidity Index, treatment and outcome. Results One hundred and eighty @entity0 with PM-bloodstream infection (BSI) were included; 90 cases with MDR-PM and 90 controls with sensitive PM (S-PM). Compared to controls, cases more frequently were from nursing homes, had recurrent hospital admissions in the past year and received antibiotic therapy in the previous 3 months, were bedridden and suffered from @entity2 and @entity5 (p   <   0.001). Two-thirds of the MDR-PM isolates were ESBL-producers vs 4.4% of S-PM isolates (p   <   0.001, OR   =   47.6, 95% CI   =   15.9-142.6). In-hospital crude mortality rate of @entity0 with MDR-PM BSI was 37.7% vs 23.3% in those with S-PM BSI (p   =   0.0359, OR   =   2, 95% CI   =   1.4-3.81). Conclusions PM @entity3 in elderly and functionally-dependent @entity0 is likely to be caused by nearly pan-resistant PM strains in the institution; 51.8% of the @entity0 received inappropriate empiric antibiotic treatment. The crude mortality rate of @entity0 with MDR-PM BSI was significantly higher than that of @entity0 with S-PM BSI.

title: @entity1 caused by multi-drug resistant XXXX : Epidemiology, risk factors and impact of multi-drug resistance.

answer: @entity4


abstract: UNASSIGNED: The current study reassesses the prevalence of @entity2 and lifetime costs in the Eastern Province of Saudi Arabia. Forty-two percent (391) of the @entity2 were at the neck of the femur, and 38.6  % (354) were inter-trochanteric @entity2 . The overall incidence was assessed to be 7528 (1,300,336 population 55  years or older) with the direct cost of SR564.75 million ( 150.60 million). A National @entity2 Registry and @entity1 awareness programs are recommended. PURPOSE: Proximal femur @entity2 are reported to be increasing worldwide due to increased life expectancy. The current study is carried out to assess the incidence of such @entity2 in the Eastern Province of Saudi Arabia and to assess the costs incurred in managing them annually. Finally, by extrapolating the data, the study can calculate the overall economic burden in Saudi Arabia. METHODS: The data of @entity2 was collected from 24 of 28 hospitals in the Eastern Province. The data included age, sex, mode of injury, type of @entity2 , prescribed drug (and its cost), and length of hospital stay. Population statistics were obtained from the Department of Statistics of the Saudi Arabian government Web site. RESULTS: Twenty-four hospitals (85  %) participated in the study. A total of 780 @entity2 were sustained by 681 @entity0 . Length of stay in the hospital averaged 23.28        13.08  days. The projected @entity2 rate from all the hospitals would be 917 (an incidence of 5.81/1000), with a total cost of SR68.77 million. Further extrapolation showed that the overall incidence could be 7528 (1,300,336 population 55  years or older) with the direct cost of SR564.75 million ( 150.60 million). CONCLUSIONS: @entity1 -related @entity3 in Saudi Arabia are significant causes of morbidity besides incurring economic burden. We believe that a National @entity2 Registry needs to be established, and @entity1 awareness programs should be instituted in every part of Saudi Arabia so that these @entity0 can be diagnosed early and treated appropriately to reduce both the number of @entity2 and the economic burden of the @entity2 .

title: Reassessment of XXXX and economic burden in Saudi Arabia.

answer: @entity3


abstract: UNASSIGNED: 9722 Background: The serum troponin-T ( @entity5 ) level increases with @entity2 . We sought to assess whether @entity5 level could be a useful marker for the early detection of @entity4 @entity3 . METHODS: 41 @entity0 who had been planned to receive @entity4 containing combination chemotherapy were included into the study. Serum @entity5 levels were measured before (baseline) and after first cycle of chemotherapy, and repeated after the last cycle of chemotherapy. In all @entity0 , the left ventricular ejection fraction (LVEF), fractional shortening (FS), early peak flow/atrial flow (E/A) velocity ratio, and the isovolemic relaxation time (IRT) were measured echocardiographically, both before and after the study. RESULTS: LVEF and FS did not change in any @entity0 . In 21 @entity0 (49%), the E/A ratio decreased after therapy. The decrease in E/A ratio was more prominent in @entity0 who were older than mean age of our study group which was 44 years (p<0.05). The post-therapy IRT was prolonged (94.0  2.0 vs 85.6  10.5 msec). @entity5 levels after completion of therapy were elevated in 14 (34%) @entity0 , but it exceeded the upper limit of normal range (>0.01 ng/mL) only in a single case. @entity5 levels after completion of therapy were significantly higher, compared to those baseline and after the first cycles of therapy (p<0.05). In the younger age group (<= 44 years), there was a 2-fold decrease in the E/A ratio in @entity0 whose @entity5 levels increased during the therapy, compared to those whose @entity5 levels did not change (21% vs 43%, p<0.05) (Table 1). CONCLUSIONS: Increased serum @entity5 levels can be detected in the early stages of @entity4 therapy and it is associated with @entity1 of the left ventricle. Therefore, serum @entity5 level could be a useful marker for the early detection of @entity4 -induced @entity2 . [Figure: see text] No significant financial relationships to disclose.

title: Increased Troponin-T level is associated with @entity4 -induced XXXX of the left ventricle.

answer: @entity1


abstract: BACKGROUND: Simple neurectomy is a standard treatment of @entity2 after failure of conservative treatment. Recently, neurectomy with intramuscular implantation of the proximal nerve stump has been proposed as a safe and effective alternative method providing significant @entity1 improvement. However, there remains little evidence supporting one technique over the other. The purpose of this study was to compare functional outcomes and complications of simple neurectomy versus neurectomy with intramuscular implantation. METHODS: Retrospective chart review along with prospectively collected data of 99 consecutive @entity0 (105 feet with 118 @entity2 ) who were diagnosed with @entity2 of the foot and underwent simple neurectomy (66 @entity0 / 72 feet / 78 @entity2 ) and neurectomy with intramuscular implantation of proximal nerve stump into intrinsic muscle of foot (33 @entity0 / 33 feet / 40 @entity2 ) between 2000 and 2013. The minimum follow-up to be included in the study was 6 months for both techniques (mean = 44.6 months, range = 6 to 150 months for simple neurectomy; and mean = 19.3 months, range = 6 to 66 months for neurectomy with intramuscular implantation of proximal nerve stump into the intrinsic muscle). The primary outcomes were @entity3 ( @entity3 ); @entity1 , disability, activity limitation, and total score, Short Form-36 (SF-36: physical and mental component scores); and visual analog scale (VAS). Secondary outcomes included operative time and complications. Pre- and postoperative SF-36, and @entity3 , and @entity1 (VAS) scores were obtained and compared using a paired t test. An independent t test was used to assess the functional outcomes and operative time between the 2 groups, and a chi-square test was used to compare the complications between the 2 techniques. RESULTS: Both groups demonstrated signi   cant improvement of postoperative functional outcomes ( @entity3 , SF-36, and VAS; P < .001, all) compared to the preoperative period. Neurectomy with intramuscular implantation demonstrated significant improvement of @entity1 compared to simple neurectomy as measured with VAS (P = .002); however, the operative time was significantly longer than the simple neurectomy technique (P = .001). The rest of the functional outcomes measured were comparable between the 2 techniques. Complications in both simple neurectomy and implantation techniques were persistent @entity1 (11.5% vs 2.5%, P = .07), revision rate (5.1% vs 0.0%, P = .08), and @entity1 (5.1% vs 5.0%, P = .83), respectively, but it did not reach statistical significance (P > .05, all). CONCLUSION: Both simple neurectomy and neurectomy with intramuscular implantation demonstrated significant improvement in terms of functional outcomes as measured with the @entity3 , SF-36, and VAS in @entity0 with @entity2 . Although requiring a longer operative time, neurectomy with intramuscular implantation technique might offer superior @entity1 relief with comparable complications to the simple neurectomy technique. LEVEL OF EVIDENCE: Level III, retrospective comparative study.

title: Simple Neurectomy Versus Neurectomy With Intramuscular Implantation for XXXX : A Comparative Study.

answer: @entity2


abstract: OBJECTIVE: Many @entity0 with @entity4 ( @entity9 ). Because open repair is associated with a high morbidity and mortality, hybrid approaches to @entity9 repair are emerging. In this study, we evaluated the midterm outcomes and aortic remodeling of a hybrid technique that combines proximal @entity3 repair (TEVAR), followed by staged distal open thoracoabdominal repair for @entity0 with Crawford extent I or II TAAAs secondary to chronic @entity8 . METHODS: We identified 19 @entity0 with Crawford extent I (n  = 1) or extent II (n  = 18) TAAAs secondary to chronic @entity8 who underwent a staged hybrid repair from 2007 to 2014 at our institution. Nine @entity0 had previous open ascending aortic surgery for type I @entity8 . Stage 1 TEVAR was performed via percutaneous (n  = 8), femoral cutdown (n  = 8), or iliac exposure (n  = 3). The left subclavian artery was covered in nine @entity0 and revascularized in eight @entity0 using carotid-subclavian bypass (n  = 7) or laser fenestration (n  = 1). Stage 2 open repair was performed a median of 18  weeks later with partial cardiopulmonary bypass via left femoral arterial and venous cannulation for visceral and lower body perfusion. The open thoracoabdominal graft was anastomosed proximally in an end to end fashion with the endograft. We then assessed surgical morbidity and mortality, midterm survival, and freedom from reintervention. Aortic remodeling was measured and change in maximum aortic and false lumen diameter at last follow-up (median, 3  years) from baseline was assessed. RESULTS: There were no deaths, @entity1 , or @entity2 in this cohort. After stage 1 TEVAR, three @entity0 required repeat intervention for endoleak (type IA, n  = 1; type IB, n  = 1; type II, n  = 1) before open repair. After stage 2 open repair, there was a single delayed permanent @entity6 2  weeks after discharge. At a median 3-year follow-up (range, 6 months-6.2  years), there were no deaths, neurologic events, @entity7 , or @entity9 reinterventions. Complete false lumen @entity5 occurred in 100% of the @entity0 , with maximum false lumen diameter decreasing from 34.3     15.3  mm to 13.2     12.0  mm  (P  < .01) and total aortic diameter decreasing from 60.2     9.0  mm to 49.4     9.6  mm  (P  <  .01). CONCLUSIONS: Staged hybrid @entity9 repair, using a combination of proximal TEVAR with open distal repair, can be performed using established endovascular skills and technology coupled with traditional open aortic surgical techniques, with low surgical morbidity and mortality. In the midterm, staged hybrid @entity9 repair was associated favorable survival, aortic remodeling, and freedom from reintervention.

title: Staged hybrid repair of extensive @entity9 secondary to chronic XXXX .

answer: @entity8


abstract: OBJECTIVES: In @entity2 ( @entity2 ) and @entity4 ( @entity4 ) forefoot involvement causes disability and @entity7 . Our objective was to evaluate, in @entity2 and @entity4 @entity0 , the efficacy of two protocols combining insoles in polypropylene terephtalate ( @entity6 ) and custom @entity5 orthoses for toes on disability and @entity7 . METHODS: Twenty-four @entity0 (13 with @entity4 , 11 with @entity2 ) with @entity7 were treated with two protocols: group A (protocol A) wore @entity6 insoles (T1) for 30 days and for another 30 days @entity5 orthosis for toes were added (T2). Group B (protocol B) wore @entity6 insoles and @entity5 orthosis (T1) for 30 days and in the following 30 days only insoles (T2). At T0, T1 and T2, @entity1 , disability and function (Foot Function Index - FFI), pressure (KPA) and plantar contact areas (cm2) (baropodometer), and gait spatial-temporal parameters (GAITRite  ) were assessed. RESULTS: At T0 versus T2, both protocols reduced @entity1 , -disability and -functional limitation (p<0.05), with better results of protocol A than protocol B (p<0.05) for @entity1 and -disability. Both protocols reduced baropodometer foot plantar pressures (p<0.001), with better results for protocol A for right foot pressures (p<0.05) and increased foot contact areas (p<0.05), with no difference between them (p=NS). Gait parameters were not significantly changed by both protocols (p=NS). CONCLUSIONS: In @entity0 with @entity2 and @entity4 with @entity7 , the synergic action of @entity5 toe orthosis and @entity6 insoles improves FFI, @entity3 and increases foot plantar contact areas. Protocol A, using firstly insoles and then adding @entity5 toe orthoses, is the more efficacious.

title: A comparison of two podiatric protocols for @entity7 in @entity0 with XXXX and @entity4 .

answer: @entity2


abstract: OBJECTIVE AND IMPORTANCE: A disadvantage of transarticular and C2 pedicle screws is vertebral artery (VA) injury as a result of screw misplacement. If unilateral occlusion of the VA is present, @entity2 of the dominant side will cause fatal complications as a result of @entity3 . Several authors have recently reported the usefulness of C2 laminar screws because of their safety on @entity2 . We used transarticular and C2 laminar screws combined with the atlas hook in a @entity0 with C1-2 instability and unilateral VA occlusion, in order to reduce the risk of further @entity2 . CLINICAL PRESENTATION: A 64-year-old @entity0 with @entity1 and @entity4 . Preoperative MR angiography showed a left side VA occlusion. TECHNIQUE: The @entity0 underwent atlantoaxial, posterior fusion using a transarticular screw on the side of the occlusion and a C2 laminar screw on the dominant side combined with a bilateral atlas hook. The transarticular screw was inserted using a navigation system and image intensifier, and the laminar screw was inserted free hand. Bone grafting from the iliac crest was performed. CONCLUSION: Transarticular and C2 laminar screws fixation combined with the atlas hook in a @entity0 with unilateral VA occlusion is a useful technique, in order to reduce the risk of further @entity2 .

title: Safety of atlantoaxial fusion using laminar and transarticular screws combined with an atlas hook in a XXXX with unilateral vertebral artery occlusion (case report).

answer: @entity0


abstract: In pancreatic islet transplantation, revascularization is crucial for the graft's survival and function. In this study, the endothelium of isolated islets and revascularization and function of islet isografts in @entity0 @entity1 were investigated. Islets were isolated from Lewis @entity1 by collagenase digestion method and were examined using immunohistochemistry ( @entity4 stain) on days 0, 1, 3, and 7 after isolation. The number of @entity4 -positive cells in these isolated islets was counted (mean +/- SD %). Isografts (freshly isolated islets: group A, and islets cultured for 7 days: group B) transplanted in the renal subcapsule of @entity3 -induced @entity0 Lewis @entity1 were examined using immunohistochemistry ( @entity4 stain) on days 3, 5, and 7 after transplantation. Intravenous @entity2 tolerance tests (IVGTT) were performed on days 3 and 7 after transplantation. The number of @entity4 -positive cells in the isolated islets on days 0, 1, 3, and 7 after isolation were: 17.3 +/- 4.1%, 8.2 +/- 0.7%, 2.1 +/- 0.8%, and 0.8 +/- 0.5%, respectively (p < 0.05). On day 5 after transplantation, @entity4 -positive cells were not detected in group A and B grafts, but were detected in both groups in periphery of the islets. On day 7, @entity4 -positive microvessels were present throughout the entire graft. IVGTT values in groups A and B on days 3 and 7 after transplantation did not show significant differences. In renal subcapsular isografts in @entity0 @entity1 , revascularization into islet grafts occurs from the surrounding host tissue 5 days after transplantation, but has no influence on the response to @entity2 during this period.

title: Revascularization and function of pancreatic islet isografts in XXXX @entity1 following transplantation.

answer: @entity0


abstract: UNASSIGNED: Chromosome rearrangement is clinically and physiologically important because it can produce oncogenic fusion genes. Chromosome rearrangement requires DNA double-strand breaks (DSBs) at two genomic locations and misrejoining between the DSBs. Before DSB misrejoining, two DSB-containing chromatin regions move and pair with each other; however, the molecular mechanism underlying this process is largely unknown. We performed a spatiotemporal analysis of ionizing radiation-induced foci of @entity2 ( @entity2 ), a marker for DSB-containing chromatin. We found that some @entity2 foci were paired, indicating that the two damaged chromatin regions neighboured one another. We searched for factors regulating the foci pairing and found that the number of paired foci increased when @entity0 , @entity1 , or ATM was absent. In contrast, @entity2 depletion reduced the number of paired foci and dicentric chromosomes-an interchromosomal rearrangement. Foci were paired more frequently in heterochromatin than in euchromatin in control cells. Additionally, the reduced foci pairing in @entity2 -depleted cells was rescued by concomitant depletion of a heterochromatin building factor such as Kr  ppel-associated box-associated protein 1 or @entity3 . These findings indicate that pairing between DSB-containing chromatin regions was suppressed by @entity0 , @entity1 , and ATM, and this pairing was promoted by @entity2 through chromatin relaxation.

title: Regulation of pairing between broken DNA-containing chromatin regions by XXXX , @entity1 , ATM, and 53BP1.

answer: @entity0


abstract: The localization of the S-antigen was studied by electron microscopy in the @entity0 eye, under three conditions of adaptation: A) 24-hour dark adaptation, B) 24-hour dark adaptation and 1.5-hour light adaptation and C) light adaptation for 30 hours. The Fab' fraction of the IgG of @entity0 against the swine S-antigen was labeled with horseradish peroxidase (HRP) and was used as the marking antibody. In Group A, the HRP reaction products indicating the S-antigen were found mainly in the disk and plasma membranes of the outer segments of the photoreceptor cells. The reaction products were also found diffusely in the cytoplasm of the inner segment with the exception of the mitochondria and nucleus. In Group B, the phagosomes were found surrounded by the multilayered microvilli of the @entity1 ( @entity1 ) cells; the reaction products were scarcely found in the phagosomes but were seen in the microvilli. Some weak reaction products were also encountered in the cytoplasm of the @entity1 cells. In Group C, after 30-hour light adaptation, many phagosomes were found but they contained almost no reaction products. However, the microvilli of the @entity1 cells surrounding the phagosomes showed a fair amount of the reaction products. The cytoplasm of the @entity1 cells contained abundant reaction products, particularly in the area of the basal infoldings. The reaction products were also seen in the Bruch's membrane and the endothelial cells of the choriocapillaris. It was thought that the S-antigen is taken up by the @entity1 during phagocytosis of the shed outer segments and is transported to the choriocapillaris.

title: Localization of S-antigen under various conditions of light or dark adaptation in the XXXX .

answer: @entity0


abstract: The induction of targeted drugs for the treatment of @entity2 has changed the treatment strategy for systemic therapy. Surgical treatment for @entity2 should also be reconsidered in the light of the effect of targeted drugs. The clinical benefit of cytoreductive nephrectomy for cases of @entity2 was proved in randomized trials in the cytokine era. However, at present, there has not been level 1 evidence for this in the targeted therapy era. @entity0 with better performance status and without poor risk factors tend to benefit from cytoreductive nephrectomy. Two ongoing large-scale randomized studies might shed light on this issue. One of the remarkable differences in the efficacy between cytokines and targeted drugs, particularly @entity4 kinase inhibitors, is the reduction in the size of the @entity1 by @entity4 kinase inhibitors, including @entity3 and @entity5 . Initial experiences with targeted therapy suggest that the neoadjuvant setting of @entity4 kinase inhibitors could be a viable option when the @entity1 shows local invasion and/or is unresectable. The present study does not support the routine neoadjuvant use of @entity3 because of the possibility of disease progression during the neoadjuvant therapy, and modest response and benefit. @entity5 , in contrast, shows larger reduction in the size of the @entity1 and might be used in the near future. Another issue is the combination of targeted therapy with metastasectomy. There is a lack of evidence for improved prognosis resulting from the neoadjuvant setting of @entity4 kinase inhibitors followed by metastasectomy. Further studies are warranted to investigate this.

title: Treatment strategies for advanced XXXX : A new paradigm for surgical treatment.

answer: @entity2


abstract: BACKGROUND AND AIMS: We published that threatening life experiences and adverse family relations impact @entity0 ( @entity0 ) adversely. In this study, we examine the influence of these stressors in @entity1 ( @entity1 ). PATIENTS AND METHODS: Patients completed demography, @entity2 ( @entity2 ), the Patient-Simple Clinical @entity3 Activity Index (P-SCCAI), the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Short-Form Health Survey (SF-36), the Brief Symptom Inventory (BSI), the Family Assessment Device (FAD), and the List of Threatening Life Experiences (LTE). Analysis included multiple linear and quantile regressions and structural equation modeling, comparing @entity0 . RESULTS: @entity1 patients (N=148, age 47.55  16.04 years, 50.6% women) had scores [median (interquartile range)] as follows: SCAAI, 2 (0.3-4.8); FAD, 1.8 (1.3-2.2); LTE, 1.0 (0-2.0); SF-36 Physical Health, 49.4 (36.8-55.1); SF-36 Mental Health, 45 (33.6-54.5); Brief Symptom Inventory-Global Severity Index (GSI), 0.5 (0.2-1.0). SIBDQ was 49.76  14.91. There were significant positive associations for LTE and SCAAI (25, 50, 75% quantiles), FAD and SF-36 Mental Health, FAD and LTE with GSI (50, 75, 90% quantiles), and @entity2 with SF-36 and SIBDQ. The negative associations were as follows: LTE with SF-36 Physical/Mental Health, SIBDQ with FAD and LTE, @entity2 with GSI (all quantiles), and P-SCCAI (75, 90% quantiles). In structural equation modeling analysis, LTE impacted @entity2 negatively and @entity2 impacted GSI negatively; LTE impacted GSI positively and GSI impacted P-SCCAI positively. In a split model, @entity2 had a greater effect on GSI in @entity1 than @entity0 , whereas other path magnitudes were similar. CONCLUSION: Threatening life experiences, adverse family relations, and poor @entity2 make @entity1 patients less healthy both physically and mentally. The impact of @entity2 is worse in @entity1 than @entity0 .

title: Effect of threatening life experiences and adverse family relations in XXXX : analysis using structural equation modeling and comparison with @entity0 .

answer: @entity1


abstract: Studying saccades can illuminate the more complex decision-making processes required for everyday movements. The double-step task, in which a target jumps to two successive locations before the subject has time to react, has proven a powerful research tool to investigate the brain's ability to program sequential responses. We asked how @entity0 with a range of @entity1 responded to the double-step task, specifically, whether the initial saccadic response made to a target is affected by the appearance of a second target jump. We also sought to determine whether cerebellar @entity0 were able to make corrective saccades towards the remembered second target location if it were turned off soon after presentation. We tested saccades to randomly interleaved single- and double-step target jumps to eight locations on a circle. @entity0 's initial responses to double-step stimuli showed 50% more error than saccades to single target jumps, and often, they failed to make a saccade to the first target jump. The presence of a second target jump had similar, but smaller effects in control subjects (error increased by 18%). During memory-guided double-step trials, both @entity0 and controls made corrective saccades in darkness to the remembered location of the second jump. We conclude that in cerebellar @entity0 , the second target jump interferes with programming of the saccade to the first target jump of a double-step stimulus; this defect highlights @entity0 ' impaired ability to respond appropriately to sudden, conflicting changes in their environment. Conversely, since cerebellar @entity0 can make corrective memory-guided saccades in darkness, they retain the ability to remember spatial locations, possibly due to non-retinal neural signals (corollary discharge) from cerebral hemispheric areas concerned with spatial localization.

title: Effects of XXXX on sequences of rapid eye movements.

answer: @entity1


abstract: OBJECTIVE: To characterize @entity0 with @entity2 that only occur without their @entity3 (SWA). METHODS: Twenty-four @entity0 with SWA were retrospectively identified by chart review and subsequently underwent video-EEG monitoring (VEM). Eleven @entity0 met selection criteria for SWA and were never aware of any @entity2 . A case-matched control group of @entity0 who were always aware (SA) was used for comparison. Statistical analysis included Pearson's Chi-square, Fisher's Exact, and Mann-Whitney. RESULTS: @entity0 with SWA were older at @entity2 diagnosis than those with SA (p=0.04), were less often referred for evaluation of @entity2 or @entity1 (p=0.04), and were referred faster for VEM, despite SWA were significantly less likely to include motor manifestations (p=0.0004). SWA more often had temporal lobe onsets (p<0.0001) with left lateralization on ictal EEG (p<0.0001). At final follow up, @entity0 with SWA had tried fewer antiseizure drugs (p=0.03), but reported @entity2 freedom as often as @entity0 with SA (p=0.4). SIGNIFICANCE: We suggest that @entity0 with SWA have a @entity1 . @entity0 with absent recall were older, referred later, had fewer motor signs, and dominant hemisphere limbic localization than @entity0 with SA, but fewer antiseizure drugs are used in treatment. @entity0 with SWA can be detected from the clinical history, though serial VEM is needed to validate effective management.

title: Focal @entity2 without XXXX .

answer: @entity3


abstract: OBJECTIVE: The Zenith Renu @entity6 ( @entity6 ) Ancillary Graft (Cook Medical Inc, Bloomington, Ind) provides active proximal fixation for treatment of pre-existing endografts with failed or failing proximal fixation or seal. The purpose of this study was to evaluate the midterm outcomes of treatment with this device. METHODS: From September 2005 to November 2006, a prospective, nonrandomized, multicenter, postmarket registry was utilized to collect physician experiences from 151 cases (89 converters and 62 main body extensions) at 95 institutions. Preoperative indications and procedural and postimplantation outcomes were collected and analyzed. Technical success and clinical success were determined as defined by the Society of Vascular Surgery reporting standards. RESULTS: @entity0 were predominantly male (87%) with a mean age of 77 years. The interval between the original endograft implantation to Renu treatment was 43.4    18.7 months. The indications for treatment were @entity7 (n = 111), migration (n = 136), or both (n = 94). Technical success was 98.0% with two cases of intraoperative conversion and one case of persistent @entity7 . The median follow-up for the cohort was 45.0 months (range, 0-56 months; interquartile range, 25.0 months). Overall, 32 cases had treatment failures that included at least one of the following: @entity2 (n = 5), @entity7 (n = 18), graft infection (n = 1), @entity5 (n = 1), @entity4 >5 mm (n = 9), @entity3 (n = 4), conversion (n = 9, with 7 after 30 days), and migration (n = 1). Overall, the clinical success for the entire cohort during the follow-up period was 78.8% (119/151). CONCLUSIONS: The postmarket registry data confirm that the Zenith Renu @entity6 Ancillary Graft can be used to treat endovascular repairs that failed due to @entity1 . The salvage treatment with the Renu device had high technical success rate and resulted in clinical success in a majority of @entity0 (78.8%). While failed endovascular repairs can be salvaged, a clinical failure in one of five @entity0 still emphasizes the importance of @entity0 and device selection during initial @entity4 repair to ensure durable success.

title: Midterm outcomes of the Zenith Renu XXXX Ancillary Graft.

answer: @entity6


abstract: UNASSIGNED: Pollen grains are well established to be an important cause of @entity4 . Current pharmacologic therapies for @entity3 do not cure the disease. Allergen specific immunotherapy is the only treatment method which re-directs the immune system away from @entity3 leading to a long lasting effect. The mechanism by which immunotherapy achieves this goal is an area of active research world-wide. The present experimental study was designed to develop an experimental model of @entity2 based on a relevant @entity0 allergen, Alstonia scholaris pollen, and to establish the immunological and cellular features of specific allergen immunotherapy using this same pollen extract. Our results revealed that Alstonia scholaris pollen sensitization and challenge causes eosinophilic @entity1 with mucin hypersecretion. This is associated with increased total IgE, increased expression of Fc  RI on lung mast cells and increased levels of @entity7 , @entity8 _ @entity6 as confirmed by ELISA, in-situ immunofluorescence and FACS assay. Allergen specific immunotherapy reduced @entity1 and also decreased total IgE level, Fc  RI expression, @entity7 , @entity8 _ @entity6 levels. It was further noted that the reduction of these levels was more by intra-nasal route than by intra-peritoneal route. Thus we present a novel animal model of @entity5 and specific allergen immunotherapy which will pave the way towards the development of better treatment modalities.

title: Specific allergen immunotherapy attenuates XXXX in a rat model of Alstonia scholaris pollen induced airway allergy.

answer: @entity1


abstract: AIM: The aim of this study was to assess the @entity2 ( @entity2 ) as biomaterial used in autogenous tooth transplantation. MATERIAL AND METHODS: The study consisted of 3 @entity1 , 5 months old, in which six incisors and six premolars were transplanted to mechanically prepared @entity0 . One group of teeth was transplanted to a recipient bed, with @entity2 in the root surface. The second groups of teeth were transplanted using saline solution in the root surface. Every week, clinical examinations were done. Nine weeks later, the animals were killed and the specimens decalcified and prepared for histological and imunohistochemical analysis. Periodontal healing was evaluated by undertaking histomorphometric investigation and analyzed using the Mann- Whitney test (P = 0.05). RESULTS: In both groups, all the transplanted teeth survived. Between the experimental groups, there was statistically significant difference in the complete healing (P = 0.004). There was statistically significant difference between the treatment group in the occurrence of inflammatory root resorption (P = 0.015) and the occurrence of replacement root resorption (P = 0.041). CONCLUSIONS: Emdogain gel used on the surface of transplanted teeth improves the occurrence of complete healing and reduces root resorption.

title: The effect of Emdogain gel on periodontal regeneration in autogenous transplanted XXXX 's teeth.

answer: @entity1


abstract: UNASSIGNED: A distinct seasonal pattern in total and @entity1 rates has been reported. The factors contributing to this pattern have not been fully explored. Seven locations (average total population 71,354,000) were selected where data were available including relatively warm, cold, and moderate temperatures. Over the period 2004 to 2009, there were 2,526,123 all-cause deaths, 838,264 circulatory deaths, 255,273 @entity2 deaths, and 135,801 @entity3 ( @entity3 ) deaths. We used time series and multivariate regression modeling to explore the association between death rates and climatic factors (temperature, dew point, precipitation, barometric pressure), influenza levels, air pollution levels, hours of daylight, and day of week. Average seasonal patterns for all-cause and @entity1 were very similar across the 7 locations despite differences in climate. After adjusting for multiple covariates and potential confounders, there was a 0.49% increase in all-cause death rate for every 1  C decrease. In general, all-cause, circulatory, @entity2 and @entity3 death rates increased linearly with decreasing temperatures. The temperature effect varied by location, including temperature's linear slope, cubic fit, positional shift on the temperature axis, and the presence of circulatory death increases in locally hot temperatures. The variable effect of temperature by location suggests that @entity0 acclimatize to local temperature cycles. All-cause and circulatory death rates also demonstrated sizable associations with influenza levels, dew point temperature, and barometric pressure. A greater understanding of how climate, temperature, and barometric pressure influence cardiovascular responses would enhance our understanding of circulatory and @entity3 deaths.

title: Relation of XXXX Rates to Climate System, Temperature, Barometric Pressure, and Respiratory Infection.

answer: @entity1


abstract: BACKGROUND: @entity1 is difficult to treat, and the available options are often inadequate. The expectorant @entity10 also acts as a strong local anaesthetic and blocks @entity6 channels about 40 times more potently than @entity8 . It preferentially inhibits the channel subtype @entity11 , which is expressed especially in nociceptive C-fibres. In view of the low @entity4 of @entity10 , it seemed reasonable to try using it for the treatment of @entity1 that failed to respond to other standard options. MATERIAL AND METHODS: The medical records of seven @entity0 with severe @entity1 and @entity5 reduction following topical @entity10 treatment are reported retrospectively. As standard therapies had not proved sufficient, a topical @entity10 20   % cream was repeatedly applied by the @entity0 in the area of @entity1 . RESULTS: The reasons for @entity1 were @entity12 (2   *), @entity9 , @entity5 , @entity5 , @entity3 and foot @entity2 of unknown origin. The individual mean @entity5 intensity reported was between 4 and 6/10 (NRS), maximum @entity5 at 6-10/10 (NRS). The @entity5 reduction achieved individually following @entity10 cream was 2-8 points (NRS) within 5-30  min and lasted for 3-8  h. @entity5 attacks were reduced in all five @entity0 presenting with this problem. Four @entity0 with no improvement after @entity8 5   % and one @entity0 with no response to @entity7 8   % nevertheless experienced a @entity5 reduction with topical @entity10 . No @entity0 reported any side effects or skin changes during a treatment that has since been continued for up to 4 years. CONCLUSION: @entity10 acts as a strong local anaesthetic and preferentially inhibits the nociceptively relevant @entity6 channel subtype @entity11 . For the first time, we report below on a relevant @entity5 relief following topical @entity10 20   % cream in @entity0 with @entity1 . In view of the positive side effect profile, the clinical benefit in @entity0 with @entity5 should be investigated further.

title: Topical XXXX for the treatment of @entity1 : An initial clinical observation. English version.

answer: @entity10


abstract: AIM: The haemodynamic effects of intravenous @entity2 have not been systematically investigated. We compared the physiological effects of intravenous @entity3 -containing @entity2 , and an equivalent dosage of @entity3 , and normal saline 0.9% in healthy volunteers. METHODS: We performed a blinded, triple crossover, randomized trial of 24 adult healthy volunteers. @entity0 received i.v. @entity2 (1  g @entity2 +3.91  g @entity3  100  ml(-1) ), i.v. @entity3 (3.91  g @entity3  100  ml(-1) ) and i.v. normal saline (100  ml). Composite primary end points were changes in mean arterial pressure (MAP), systolic blood pressure (SBP) and diastolic blood pressure (DBP) measured pre-infusion, during a 15  min infusion period and over a 45  min observation period. Systemic vascular resistance index (SVRI) and cardiac index were measured at the same time points. RESULTS: Infusion of @entity2 induced a transient yet significant decrease in blood pressures from pre-infusion values ( @entity4 .85  mmHg, 95% CI -2.6, -1.1, SBP -0.54  mmHg, 95% CI -1.7, 0.6 and @entity5 .92  mmHg, 95% CI -2.6, -1.2, P  <  0.0001), associated with a transient reduction in SVRI and an increase in cardiac index. Changes were observed, but to a lesser extent with normal saline (MAP -0.15  mmHg, @entity1 .44  mmHg, DBP --0.73  mmHg, P  <  0.0001), but not with @entity3 (MAP +1.47  mmHg, SBP +4.03  mmHg, DBP +0.48  mmHg, P  <  0.0001). CONCLUSIONS: I.v. @entity2 caused a transient decrease in blood pressure immediately after infusion. These effects were not seen with @entity3 or normal saline. The physiological mechanism was consistent with vasodilatation. This study provides plausible physiological data in a healthy volunteer setting, supporting transient changes in haemodynamic variables with i.v. @entity2 and justifies controlled studies in the peri-operative and critical care setting.

title: The haemodynamic effects of intravenous XXXX ( @entity2 ) in healthy volunteers: a double-blind, randomized, triple crossover trial.

answer: @entity2


abstract: @entity3 ( @entity3 ) is a caloric vestibular areflexia that occurs suddenly, and whose compensation can take several weeks, sometimes several months. Usually these @entity0 are rehabilitated, but the most affected @entity0 (cervical vestibular evoked myogenic potential (cVEMP) absent) have a worse prognosis of @entity4 . Thanks to symptomatic, videographic and posturographic evaluation tools, we objectify and quantify which factors influence the recovery or more accurately the compensation of this @entity1 . EQUIPMENT AND METHOD: We have colligated 34 observations of @entity3 whose beginning could be precisely dated. These 34 unilateral caloric areflexic @entity0 had a @entity2 ( @entity2 ) with scales (vertigo symptom scale, dizziness handicap inventory, short form 36), an evaluation of the vestibulo-ocular reflex (VOR) (spontaneous nystagmus, head shaking test, mastoid bone skull vibration test, and finally an evaluation of the vestibulo-spinal function (VSF) on a dynamic posturography platform (DPY). On the other hand were evaluated eight elements supposed to influence (influence factors FI) the care and/or the outcome of the treatment (age, cVEMP absent, duration of deficiency, sports and walk practice, rehabilitation of VOR, rehabilitation of VSF, waiting period before application of rehabilitation, vertigo medications treatment). RESULTS: By comparing averages and with a Fischer's exact test, we can show here that the medical treatment, the waiting period before the application of the rehabilitation, the number of rehabilitation sessions or the type of rehabilitation influence only partially the state of health of @entity5 . The age of the @entity0 and absent cVEMP don't have a major influence either. However, @entity0 with the most important physical activity feel better from a symptomatic point of view, over a long period after the episode. The effect of rehabilitation might be temporary if daily activity is minimal. CONCLUSION: The evaluation of the vestibulo-ocular reflex has long remained the main element for the evaluation of the state of health of @entity3 . But if you use in addition posturography and symptomatic scales to assess the state of health, the @entity5 considered to be compensated with the VOR will not always be symptomatically compensated. Estimating the functional recovery of @entity5 can't be limited to estimating or quantifying the VOR. @entity5 can't be limited to rehabilitating the VOR. Finally we show here that physical activity is probably more necessary than any type of rehabilitation.

title: XXXX : Evaluation and effect of vestibular rehabilitation.

answer: @entity3


abstract: CONTEXT: @entity6 and chronic subclinical @entity2 in adults are associated with the development of @entity0 and @entity3 . The potential relationship between @entity4 and @entity2 and its modulation by lifestyle intervention in the pediatric @entity1 population remain unclear. OBJECTIVES: The objectives were to investigate in adolescents 1) the relationship between @entity4 and @entity1 -related inflammatory factors, C-reactive protein, and @entity7 ) the effect of a lifestyle intervention on @entity4 and whether these effects are related to changes in inflammatory factors. RESEARCH METHODS AND PROCEDURES: Twenty-one @entity1 and age-matched lean adolescents (age, 14-18 yr; Tanner stage, > or =IV) were studied cross-sectionally. Fifteen @entity1 adolescents also underwent a randomized, controlled physical activity-behavior-diet-based lifestyle intervention for 3 months. Associations among @entity4 , fat mass, insulin resistance, and inflammatory factors at baseline as well as after the intervention were assessed. RESULTS: Plasma @entity4 concentration was lower (P < 0.001) in the @entity1 vs. age-matched lean adolescents. Significant inverse relationships were observed between @entity4 and inflammatory factors, insulinemia, insulin resistance, and fat mass. Intervention produced a 34% increase in @entity4 concentration (P = 0.0004) despite negligible weight loss but with reductions in fat mass, @entity5 , insulin resistance, and inflammatory factors (all P < 0.01). CONCLUSIONS: The data suggest that in adolescents, @entity1 -related @entity6 is associated with subclinical @entity2 , and a short-term lifestyle intervention augments @entity4 concentrations. These effects appear to be related to reductions in fat mass and inflammatory factors. Based on our current understanding of @entity4 physiology, reversal of @entity6 in @entity1 adolescents may protect against risks for @entity3 and @entity0 .

title: Reversal of XXXX -related @entity6 by lifestyle intervention: a controlled, randomized study in @entity1 adolescents.

answer: @entity1


abstract: The @entity0 ( @entity0 ) of the vertebrate embryonic neural tube develops in response to the isthmic organizer (IsO), located at the midbrain-hindbrain boundary (MHB). @entity0 derivatives are largely missing in mutants affected in IsO activity; however, the potentialities and fate of @entity0 precursors in these conditions have not been directly determined. To follow the dynamics of @entity0 maintenance in vivo, we used artificial chromosome transgenesis in @entity1 to construct lines where egfp transcription is driven by the complete set of regulatory elements of @entity3 , the first known gene expressed in the @entity0 area. In these lines, egfp transcription faithfully recapitulates @entity3 expression from its induction phase onwards. Using the stability of GFP protein as lineage tracer, we first demonstrate that @entity3 expression at gastrulation is a selective marker of @entity0 precursor fate. By comparing GFP protein and @entity3 transcription, we further reveal the spatiotemporal dynamics of @entity3 expression that conditions neurogenesis progression towards the MHB over time. Finally, we trace the molecular identity of GFP-positive cells in the acerebellar (ace) and no-isthmus (noi) mutant backgrounds to analyze directly @entity2 and @entity4 mutant gene activities for their ultimate effect on cell fate. We demonstrate that most @entity0 precursors are maintained in both mutants but express abnormal identities, in a manner that strikingly differs between the ace and noi contexts. Our observations directly support a role for @entity2 in protecting anterior tectal and metencephalic precursors from acquiring anterior identities, while @entity4 controls the choice of @entity0 identity as a whole. Together, our results suggest a model where an ordered @entity0 pro-domain is identified at gastrulation, and where cell identity choices within this domain are subsequently differentially controlled by @entity2 and @entity4 functions.

title: Tracing of @entity3 progeny in XXXX transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance.

answer: @entity1


abstract: BACKGROUND: The purpose of the study was to examine the @entity1 related health care utilization in @entity0 with @entity2 syndrome. METHODS: In a multicenter study six rheumatological hospitals associated in the rheumatological center of Heidelberg participated. All consecutive @entity0 which fulfilled the @entity3 -criteria of @entity2 were assessed. Data about @entity1 and related treatments were available from n=259 @entity0 . RESULTS: @entity0 suffered from chronic generalized @entity1 on average for 5 years before being diagnosed as @entity2 . In most of the cases longlasting localized @entity1 symptoms preceeded generalized @entity1 . The spectrum of @entity1 related treatments seems to be wide and arbitrary: 87% took questionable or excessive medication. 86% had some form of physiotherapy and 41% already experienced psychological treatment. 28% of the @entity0 consulted dental surgeons including teeth extraction and 20% underwent multiple orthopaedic surgery. A mean of five different health care professionals were consulted regarding the @entity1 problem. Treatment satisfaction rated by the @entity0 was lowest with pharmacological and highest with psychological treatment and physiotherapy. CONCLUSIONS: The health care-seeking behavior of @entity2 - @entity0 seems to be characterized by a multitude of different treatment attempts. Treatment was often invasive and focused on localized symptoms rather than on the generalized @entity1 . An early confirmation of the diagnosis and a more evidence based treatment is strongly indicated.

title: [Health care utilization in @entity0 with XXXX ( @entity2 )].

answer: @entity2


abstract: PURPOSE: To report correlation between retinal and @entity8 and to evaluate pathogenesis of @entity11 in the @entity10 ( @entity10 ). DESIGN: Observational case series. METHODS: Seventy-five @entity0 with apparent nonaccidental head @entity1 consistent with @entity10 had complete physical examination, complete ophthalmologic examination, neuroimaging by CT or MRI, or both, and skeletal radiographic survey. In this retrospective review, ophthalmoscopic and @entity8 were correlated. RESULTS: The age of @entity0 ranged from 2 to 48 months (mean - SD, 10.6 +/- 10.4 months). Neuroimaging was abnormal in all 75 cases. Findings included subdural @entity7 (70 @entity0 , 93%), @entity9 (33 @entity0 , 44%), @entity3 (12 @entity0 , 16%), vascular @entity6 (nine @entity0 , 12%), intraparenchymal blood (six @entity0 , 8%), parenchymal contusion (six @entity0 , 8%), and @entity4 (one @entity0 , 1%). Sixty-four (64/75, 85%) @entity0 had @entity5 , mostly (53/64, 82%) confluent multiple @entity4 that were subretinal, intraretinal, and preretinal in 47/64 (74%) and bilateral in 52/64 (81%). No association was found between anatomic site (left, right, or bilateral) of intracranial and retinal findings (McNemar test kappa = -0.026-0.106) or between any of the intracranial findings mentioned above and the following retinal findings: normal or abnormal retinal examination, multiple (>10) or few @entity11 (< or =10), symmetric or asymmetric retinal findings, or @entity12 (kappa = -0.127-0.104). Signs of possible @entity2 were not correlated with any @entity5 (kappa = -0.03-0.073). There was no correlation between evidence of impact @entity1 to the head and @entity11 (kappa = 0.058). Total Cranial @entity1 Score and Total @entity11 Score, both indicating the severity of injury, were correlated (P =.032). CONCLUSIONS: Our study supports previous observations that the severity of retinal and @entity8 is correlated in @entity10 . We cannot support the suggestions that in most @entity0 with @entity10 retinal @entity4 is caused by sustained elevated intracranial, elevated intrathoracic pressure, direct tracking of blood from the intracranial space, or direct impact @entity1 . The correlation in severity of both eye and head findings may suggest, however, that @entity5 are the result of mechanical shaking forces.

title: Correlation between @entity5 and @entity8 in the XXXX .

answer: @entity10


abstract: BACKGROUND AND PURPOSE: @entity5 ( @entity5 ) is a rare, aggressive @entity2 . We report survival rates and @entity3 associated with sequential multimodality treatment including @entity4 ( @entity4 ). MATERIAL AND METHODS: Medical records of 32 @entity0 with @entity5 treated at our institution were reviewed. @entity0 underwent chemotherapy, cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC), followed by @entity4 with intensity-modulated radiation or volumetric-modulated arc therapy. RESULTS: Median overall survival (OS) was 60months. After 18months of follow-up, 20 @entity0 (62.5%) had disease recurrence and median disease-free survival (DFS) was 10months. Median time to extrahepatic abdominal failure was 19.4months. Factors affecting time to local progression included liver @entity1 at diagnosis, and an interval of greater than 5.6months between diagnosis and HIPEC or greater than 2.1months between HIPEC and @entity4 . None of these factors altered OS. Grade 3 or higher @entity3 occurred in 84% of @entity0 . CONCLUSIONS: @entity4 following chemotherapy, surgical cytoreduction and HIPEC is an aggressive treatment for @entity5 @entity0 and can result in severe side effects. Our median OS of 5years is favorable compared to prior studies, despite a median DFS of only 10months, which may be due to improved salvage therapies.

title: Survival and @entity3 following sequential multimodality treatment including whole abdominopelvic radiotherapy for @entity0 with XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a progressive @entity1 . Because of its inflammatory nature, several circulating markers were investigated for predicting disease progression. We aimed to investigate simple inflammatory blood markers as predictors of clinical class and disease severity in @entity0 with @entity3 . Eighty @entity0 with @entity3 were divided into three groups according to clinical class (grade 1, 2 and 3) and score of disease severity (mild, moderate and severe). The basic inflammatory blood markers [neutrophil, lymphocyte, mean platelet volume ( @entity4 ), white blood cell (WBC), platelet, albumin, D-dimer, @entity2 , @entity2 to albumin ratio, and neutrophil to lymphocyte ratio] were investigated in each group. Serum neutrophil, lymphocyte, @entity4 , platelet count, D-dimer and neutrophil to lymphocyte ratio levels were similar among the groups (P>0.05). Although the serum WBC levels were significant in the clinical severity groups (P<0.05), it was useless to separate each severity class. However, albumin, @entity2 and the @entity2 to albumin ratio were significant predictors of clinical class and disease severity. Especially, the @entity2 to albumin ratio was detected as an independent indicator for a clinical class and disease severity with high sensitivity and specificity (75% sensitivity and 87.5% specificity for clinical class and 90% sensitivity and 88.3% specificity for disease severity). Serum @entity2 and albumin levels can be useful parameters to determine clinical class and disease severity in @entity0 with @entity3 . Moreover, the @entity2 to albumin ratio is a more sensitive and specific predictor of the progression of @entity3 .

title: Simple blood tests as predictive markers of disease severity and clinical condition in @entity0 with XXXX .

answer: @entity3


abstract: UNASSIGNED: Background and study aims: The transnasal endosheath endoscope is a new disposable technology with potential applicability to the primary care setting. The aim of this study was to evaluate the efficacy of transnasal endosheath endoscopy (TEE) for the detection of @entity1 , by comparing the diagnostic accuracy of TEE with that of standard endoscopy. @entity0 and methods: This was a prospective, randomized, crossover study performed in a single tertiary referral center. Consecutive @entity0 undergoing surveillance for @entity1 or referred for diagnostic assessment were recruited. All @entity0 were randomized to undergo TEE followed by standard endoscopy or the reverse. Endoscopy experiences and @entity0 preferences were evaluated using a questionnaire. Endoscopic and histologic diagnosis of @entity1 , and optical image quality of both endoscopic procedures, were compared. Results: A total of 21 of 25 @entity0 completed the study. TEE had sensitivity and specificity of 100% for an endoscopic diagnosis of @entity1 , and of 66.7% and 100%, respectively, for the histologic diagnosis of @entity1 . The mean optical quality of standard endoscopy was significantly better than that of TEE (7.11  0.42 vs. 4.06  0.27; P<0.0001). However, following endoscopy, @entity0 reported a significantly better experience with TEE compared with standard endoscopy (7.05  0.49 vs. 4.35  0.53; P=0.0006), with 60% preferring TEE and 25% preferring sedated standard endoscopy. Conclusions: In this study, TEE had equal accuracy for an endoscopic diagnosis of @entity1 compared with standard endoscopy, at the expense of reduced image quality and a lower yield of intestinal metaplasia on biopsy. TEE was better tolerated and preferred by @entity0 . Hence, TEE needs further evaluation in primary care as an initial diagnostic tool.

title: Pilot randomized crossover study comparing the efficacy of transnasal disposable endosheath with standard endoscopy to detect XXXX .

answer: @entity1