abstract: UNASSIGNED: 877 Background: @entity4 is an active drug in @entity0 : 37% of responses as first line, 26% as a second line and 18% as tirad line; The responses with @entity4 plus @entity9 is @entity1 with MBC is: 40% to 80%. @entity14 has not been identified as active drug in @entity0 , however @entity4 hs an wide synergism with this drug. METHODS: The aim of this study was to evaluate the efficacy and security of the chemotherapy with @entity4 and @entity14 in recurrent @entity0 . All @entity1 had clinically and by scan CT, measurable disease. TREATMENT: @entity4 1000 mg/m2 days 1 and 8, @entity14 AUC 5 day 1, Cycles repeated q21 days as blood count permitted until limited @entity5 or progression. RESULTS: 19 @entity1 were treated with palliative chemotherapy with GC, and there were 69 courses of chemotherapy. All pts received @entity17 , FAC 15 pts, @entity15 pt and 3 pts combined with @entity16 in adjuvant setting; all received radiotherapy after adjuvant chemotherapy and all received also hormonal therapy in adjuvant setting. All pts received @entity16 in recurrence and between 2 and 4 chemotherapy schedules that included: @entity7 , other @entity16 , @entity10 , @entity13 and @entity9 . Median age was 44.5 years. 15 pt had ductal adencarcinoma and 2 pts had @entity6 . . Stage II: 6 @entity1 and stage III-IV: 12 @entity1 ; median follow-up was 5.2 (3.4-10.8 mo). Objective Responses (OR) were presented in 4 pt (21.5%); CR 2 pt, PR 2 pt and Stable disease 8 pts; @entity3 ( @entity3 ) in 7 pts (31.3%); the responses were two locally and two more in the @entity2 (hepatic). Median overall survival was 7.5 mo. The current status is 4 pts alive without tumoral activity (18.7%), 12 pts alive with tumoral activity (62.6%), and 3 dead pts with tumoral activity (18.7%). Related to @entity5 was presented in 4 pts (5.79%), @entity11 in 3 pts (4.34%), @entity12 in 4 pts (5.79%) and @entity8 in 1 pt (1.44%). CONCLUSION: @entity4 plus @entity14 is an active combination (11 OR), this scheme is of an easy administration, and very well tolerated in @entity1 with metastatic and recurrent @entity0 , must be considered as an option in the metastatic setting. No significant financial relationships to disclose.

title: @entity4 plus @entity14 in recurrent and XXXX : A phase II trial.

answer: @entity0


abstract: BACKGROUND:    Trivalent oral @entity1 vaccine (OPV) is known to interfere with monovalent rotavirus vaccine (RV1) immunogenicity. The interference caused by bivalent and monovalent OPV formulations, which will be increasingly used globally in coming years, has not been examined. We conducted a post hoc analysis to assess the effect of coadministration of different OPV formulations on RV1 immunogenicity. METHODS:    Healthy @entity0 in Matlab, Bangladesh, were randomized to receive 3 doses of monovalent OPV type 1 or bivalent OPV types 1 and 3 at either 6, 8, and 10 or 6, 10, and 14 weeks of age or trivalent OPV at 6, 10, and 14 weeks of age. All @entity0 received 2 doses of RV1 at about 6 and 10 weeks of age. Concomitant administration was defined as RV1 and OPV given on the same day; staggered administration as RV1 and OPV given >= 1 day apart. Rotavirus seroconversion was defined as a 4-fold rise in immunoglobulin A titer from before the first RV1 dose to >= 3 weeks after the second RV1 dose. RESULTS:    There were no significant differences in baseline RV1 immunogenicity among the 409 @entity0 included in the final analysis. @entity0 who received RV1 and OPV concomitantly, regardless of OPV formulation, were less likely to seroconvert (47%; 95% confidence interval, 39%-54%) than those who received both vaccines staggered >= 1 day (63%; 57%-70%; P < .001). For staggered administration, we found no evidence that the interval between RV1 and OPV administration affected RV1 immunogenicity. CONCLUSIONS:    Coadministration of monovalent, bivalent, or trivalent OPV seems to lower RV1 immunogenicity. CLINICAL TRIALS REGISTRATION:    NCT01633216.

title: Interference of Monovalent, Bivalent, and Trivalent Oral XXXX Vaccines on Monovalent Rotavirus Vaccine Immunogenicity in Rural Bangladesh.

answer: @entity1


abstract: UNASSIGNED: @entity7 ) induces the formation of effector @entity5 (+) T cells that are maintained for decades during the latent stage of @entity3 . Effector @entity5 (+) T cells appear quiescent, but maintain constitutive cytolytic capacity and can immediately produce inflammatory cytokines such as @entity4 after stimulation. It is unclear how effector @entity5 (+) T cells can be constitutively maintained in a terminal stage of effector differentiation in the absence of overt viral replication. We have recently described the @entity2 finger protein Homolog of @entity8 in T cells (Hobit) in @entity1 NKT cells. Here, we show that @entity0 Hobit was uniformly expressed in effector-type @entity5 (+) T cells, but not in naive or in most memory @entity5 (+) T cells. @entity0 @entity6 -specific but not influenza-specific @entity5 (+) T cells expressed high levels of Hobit. Consistent with the high homology between the DNA-binding Zinc Finger domains of Hobit and @entity8 , Hobit displayed transcriptional activity at @entity8 target sites. Expression of Hobit strongly correlated with T-bet and @entity4 expression within the @entity5 (+) T-cell population. Furthermore, Hobit was both necessary and sufficient for the production of @entity4 . These data implicate Hobit as a novel transcriptional regulator in quiescent @entity0 effector-type @entity5 (+) T cells that regulates their immediate effector functions.

title: XXXX homolog Hobit identifies effector-type lymphocytes in @entity0 .

answer: @entity8


abstract: INTRODUCTION: Firearm injuries are a major health problem contributing to significant morbidity and mortality. @entity2 is associated with increased risk of adverse health outcomes in @entity1 @entity0 and those hospitalized for serious disorders. We examined the relation between preexisting @entity2 and adverse hospital outcomes and related @entity1 among adult (>16-years) @entity3 ( @entity3 ). METHODS: Using nationally representative Nationwide Inpatient Sample (2005 to 2011) and survey weighted multinomial logistic regression, we calculated odds ratios (OR) and 95% confidence intervals (95%CI) to determine the risk of care facility discharge and in-hospital mortality by pre-existing @entity2 . RESULTS: Pre-existing @entity2 was associated with a 3-fold risk of discharge to care facility (OR=2.91, 95%CI=2.57-3.30) and a 2-fold risk of in-hospital mortality (OR=2.05, 95%CI=1.69-2.47). ORs for risk of care facility discharge compared to routine discharge associated with @entity2 among assault/legal- @entity3 , unintentional- @entity3 , suicide- @entity3 and undetermined- @entity3 was 2.73 (95%CI=2.23-3.33), 1.90 (95%CI=1.50-2.41), 1.52 (95%CI=1.26-1.83) and 2.42 (95%CI=1.60-3.67), while risk of inhospital mortality was 0.17 (95%CI=0.05-0.54), 0.60 (95%CI=0.28-1.29), 0.79 (95%CI=0.63-0.98) and 0.74 (95%CI=0.36-1.52). LIMITATIONS: Lack of information regarding re-hospitalization due to the cross-sectional data. CONCLUSION: @entity0 with @entity2 who were hospitalized due to firearm-related injury were less likely to survive than those without @entity2 , and those discharged alive were at higher risk of discharge to a facility. @entity2 was associated with greater risk of discharge to facility among all intents, and lower risk of in-hospital mortality among assault- and suicide- @entity3 . These findings are important considering the increasing numbers of non-fatal @entity3 and the associated increase in healthcare expenditure.

title: The relation of XXXX to in-hospital outcomes among adults hospitalized for firearm-related injury.

answer: @entity2


abstract: UNASSIGNED: 4172 Background: @entity3 is one of the common problems in India. Most often this is diagnosed in locoregionally advanced or in Metastatic stage.Chemotherapy is needed in most cases of ca Stomach .This study deals with @entity3 in the rural south Indian population.This is a retrospective analysis. METHODS: The diagnosis was by endoscopic biopsy. Non Metastatic ca stomach was treated with initial surgery.Chemotherapy was offered to those with Metastatic,node positive or seosa or muscle positive @entity0 The common chemotherapy protocol used was ELF ( @entity4 100 mg/m2, @entity5 30mg/m2,5FU 350 mg/m2 all IVF d1-d3) at three weekly interval for six cycles. RESULTS: Total of eighty @entity0 were analysed.The lesion was in70% distal, 17% proximal and 13% unknown site. In 60% the infiltration was upto serosa or beyond and in 7% upto muscle.20% had liver involvement. Nodes were involved in 44% and peritoneum was involved in 15%. 29 @entity0 had adjuvant and 51 had palliative chemotherapy. All @entity0 who had adjuvant chemo had surgery(partial gastrectomy in 69%,total gastrectomy in 24% and gastro esophagectomy in 7%).37% of @entity0 on palliative chemo had surgery like partial gastrectomy, jejunostomy or gastrojejunostomy. 59%in adjuvant and 29%in palliation were regular for treatment.31% relapsed in adjuvant group.In the palliative group56%had stable disease and 44%had progressive disease.The follow up in adjuvant group was 1-155Wks(mean 36 and median 28)and in the palliative group 1 - 52 wks(mean 11 and median 5 wks). @entity2 is grade 1 or 2 and there was no @entity2 . CONCLUSION: Chemotherapy is needed for most of these @entity0 of ca stomach. ELF protocol was simple and relatively non toxic protocol.Inspite of this a fair proportion in both adjuvant and palliative groups were not regular on treatment. The main reason is unabated symptoms of @entity1 (in palliation group) and nutritional complications of gastrectomy (in the adjuvant group). Apart from addressing superior chemotherapy, we also need to investigate areas to improve @entity0 compliance, nutritional complications of gastrectomy and quality symptom management like standard gastric diversion procedure. No significant financial relationships to disclose.

title: XXXX -epidemiology and treatment results of rural South Indian experience.

answer: @entity3


abstract: Acute @entity5 is a common CNS @entity4 in @entity0 . However, there are limited studies concerning about the correlation between the clinical evaluations and neurological outcome. To investigate the value of neurological evaluations, and the correlation between these evaluations and neurological outcomes of acute @entity5 , in the present study we retrospectively evaluated the neurological outcome of 0- to 16-year-old @entity0 with @entity5 or @entity15 between 1999 and 2000. Of 101 @entity0 enrolled, 4 died and 25 had other @entity2 , including @entity7 , @entity1 , @entity6 , and emotional or behavioral changes during the 5 years of follow-up. The causative organisms in @entity0 with @entity2 ( @entity12 /2 (100%), @entity9 2/3 (67%), @entity16 5/12 (42%), and enterovirus 71 2/7 (29%). The important predictors for adverse outcomes were focal neurological signs, multiple @entity8 or @entity3 on admission, @entity11 , focal slow waves or continuous generalized delta waves in electroencephalography (EEG), and focal cortical parenchymal hyperintensity in the magnetic resonance imaging (MRI) (p<0.05). @entity0 with initial presentations of focal neurological signs, @entity13 , @entity14 , and @entity3 tended to have higher incidence of abnormal findings in brain MRI, although not achieving statistic significances. In addition, @entity0 with focal spikes or continuous generalized delta waves in EEG also had higher incidence of @entity10 . We conclude that brain MRI studies may be indicated in @entity0 with focal neurological signs, intractable @entity8 , and focal spikes, focal delta waves, or continuous generalized delta waves in EEG. For those with MRI examinations, focal cortical hyperintensity suggests poorer neurological outcomes.

title: The correlation between neurological evaluations and neurological outcome in acute XXXX : a hospital-based study.

answer: @entity5


abstract: BACKGROUND: Coronary stenting in @entity0 has been associated with worse results in terms of morbidity, mortality, and restenosis rate in the bare-metal stent @entity7 , possibly due to higher risk profile and smaller coronary vessels. Although drug-eluting stents have equalized clinical results, no data are available on long-term outcomes between sexes. OBJECTIVES: To evaluate the role of sex in acute, mid-term, and long-term clinical outcome after @entity6 -eluting stent (SES) implantation. METHODS: We retrospectively evaluated 1186 @entity0 , 970 (81.8%) male and 216 (18.2%) female, treated with SES implantation between April 2002 and December 2005. RESULTS: @entity0 were older (P=0.049), more likely to have @entity2 (43.5 vs. 33.7%, P=0.006), @entity1 (63.9 vs. 42.5%, P=0.03), and @entity5 (16.6% vs. 9.2%, P=0.001) and more frequently received small ( <= 2.75 mm) vessel stenting (39.3 vs. 28.2%, P=0.001). The two groups were similar for lesion and procedural characteristics. Overall, the stent @entity4 rate was 0.4% (0.5% in @entity0 vs. 0.3% in @entity0 , P=not significant). At 6-month follow-up, no significant difference in major adverse cardiac event was observed. Long-term follow-up (median time 33.2 months), available in 180 (83.3%) @entity0 and 720 (75%) @entity0 , showed higher angina recurrence rate (17.7 vs. 11%, P=0.013), percutaneous coronary re-intervention (16.1 vs. 8.7%, P=0.001) and target vessel revascularization (3.9 vs. 0.9%, P=0.001) in @entity0 compared with @entity0 . Late stent @entity4 , need for coronary artery bypass grafting, and mortality were similar in both groups. CONCLUSION: No sex difference was observed in acute and 6-month outcome after SES implantation despite older age, more unstable clinical presentation, and more frequent small vessel stenting in @entity0 . However, long-term clinical follow-up (up to 5 years) in @entity0 showed higher symptom recurrence and target vessel revascularization rate but no difference in overall major adverse @entity3 .

title: Sex difference in long-term clinical outcome after XXXX -eluting stent implantation.

answer: @entity6


abstract: BACKGROUND: Duplex sonography of the temporal artery may be helpful in the diagnosis of @entity2 . @entity0 AND METHODS: The superficial temporal arteries of 36 @entity0 with @entity2 or suspected @entity3 were examined using both duplex ultrasonography (US) and biopsy. The data of these @entity0 were divided into two groups. Group A consisted of 24 @entity0 (66.7%) with definite positive results using duplex (US) and Group B of 12 @entity0 (33.3%) who showed a suspicious or negative ultrasonographic result. RESULT: In all @entity0 of Group A, the histological findings corresponded with the ultrasonographic changes in the inflamed artery. - The characteristic ultrasonographic sign was a dark halo around the lumen of the temporal arteries. There was a high correlation between a bilateral halo found by US with an ocular involvement. Ten out of 14 @entity0 with a bilateral halo (71.4%) showed a distinct involvement of the optic nerve or retina. - The characteristic histological signs were infiltration of the vessel wall by inflammatory cells, mainly lymphocytes. Group B: The biopsies of the superficial temporal arteries were positive in 8 @entity0 (66.7 %), negative in 4 other @entity0 (33.3%). CONCLUSION: @entity0 with a distinct halo, demonstrated by US, also showed corresponding pronounced inflammatory cell infiltration of the vessel wall. @entity0 with no ultrasonographic changes presented histological signs of @entity1 such as isolated inflammatory cells around the vasa vasorum and/or in the adventitial layer.

title: Comparison between color duplex ultrasonography and histology of the temporal artery in XXXX ( @entity2 ).

answer: @entity2


abstract: UNASSIGNED: It is unclear whether changes in mean platelet volume ( @entity3 ) are associated with total mortality in @entity2 . We investigated whether the change in @entity3 predicts total mortality in @entity0 with @entity1 ( @entity1 ). We retrospectively analyzed 419 consecutive @entity0 (19 @entity0 were excluded). The remaining @entity0 were categorized as survivors (n = 351) or nonsurvivors (n = 49). Measurements of @entity3 were performed at admission and after 24 hours. The difference between the 2 measurements was considered as the @entity3 change (  @entity3 ). The end point of the study was total mortality at 1-year follow-up. During the follow-up, there were 49 deaths (12.2%). Admission @entity3 was comparable in the 2 groups. However, both @entity3 (9.6    1.4 fL vs 9.2    1.0 fL, P = .044) and   @entity3 (0.40 [0.10-0.70] fL vs 0.70 [0.40-1.20] fL, P < .001) at the first 24 hours were higher in nonsurvivors than survivors. In multivariate analysis,   @entity3 was an independent predictor of total mortality (odds ratio: 1.84, 95% confidence interval: 1.28-2.65, P = .001). An early increase in @entity3 after admission was independently associated with total mortality in @entity0 with @entity1 . Such @entity0 may need more effective antiplatelet therapy.

title: The Prognostic Impact of In-Hospital Change in Mean Platelet Volume in @entity0 With Non-ST-Segment Elevation XXXX .

answer: @entity1


abstract: BACKGROUND: The electrical alternans shown on an ST segment, ST alternans, is known as one of the most important predictors of @entity6 ( @entity6 ). It has also been reported that @entity4 channel inhibition changes action potential configuration, especially on the repolarization phase. Thus, the @entity4 channel blocker may produce ST alternans and trigger reentrant @entity1 . METHODS AND RESULTS: A @entity4 channel blocker ( @entity9 , @entity7 , or @entity8 ) was infused selectively into the left anterior descending coronary artery in anesthetized, open-chest @entity0 . Sixty unipolar electrograms were simultaneously recorded from the entire cardiac surface of the heart. The amplitude of ST alternans (STa) was determined as the difference in the ST-segment magnitude between 2 consecutive electrograms. We accepted the greatest STa among 60 leads for evaluation. High-dose @entity8 (100 microg. kg-1. min-1) increased STa and evoked a spontaneous @entity6 . The STa in high-dose @entity8 loading (8.7+/-3.4 mV; mean+/-SEM) was significantly greater than that in @entity9 or @entity7 (0. 9+/-0.4 and 0.8+/-0.2 mV, P<0.05). Treatment of @entity2 ( @entity3 ) suppressed the increase in STa and the occurrence of @entity6 evoked by @entity8 , while @entity10 or @entity5 did not inhibit those. CONCLUSIONS: @entity8 caused the ST alternans that was closely correlated to the occurrence of @entity6 . Because the ST alternans was suppressed by @entity3 treatment, a @entity3 -sensitive current such as Ito or Isus may play an important role on this phenomenon.

title: Intracoronary @entity8 induces ST alternans and reentrant XXXX on intact @entity0 heart: A role of @entity2 -sensitive current.

answer: @entity1


abstract: @entity4 is one of the most common @entity2 . In France, 15,000 died each year from the metastatic or locoregional progression of this @entity2 . In the past, effective surgical adjuvant therapy has been an elusive goal with no evidence of benefit from chemotherapy or immunotherapy. However, a meta-analysis published in 1988 showed that one-year adjuvant chemotherapy using @entity6 ( @entity6 ) containing regimens may slightly improve survival. Accelerated progress has been made since 1990: in @entity5 with regional nodal @entity1 (stage @entity2 ), therapy with combined @entity6 and @entity8 has resulted in a 33% reduction in the death rate. Controlled clinical trials demonstrated improved @entity2 response rates when the combination of @entity6 and @entity7 was compared with single-agent @entity6 in @entity0 with metastatic @entity3 . Recent results indicate that this combination is effective in preventing @entity2 relapse and improving survival in @entity0 with high risk @entity5 (especially stage @entity2 ). The comparison of @entity6 and @entity7 to @entity6 and @entity8 is ongoing; the preliminary results of these controlled trials showed that 6 months of adjuvant therapy with @entity6 and @entity7 is as effective as the standard 12 months @entity6 and @entity8 regimen and less toxic. No clear adjuvant benefit has been established in @entity0 with @entity2 . The lack of statistical power of the trials and the 80% overall survival rate of these @entity0 may explain these negative results. Almost all the specialists of these @entity2 considered that it is possible to select @entity0 who are at sufficiently high risk of recurrence so that treatment can be justified. These @entity0 are those who presented initially with @entity2 perforation or obstruction, adherence to or invasion of adjacent organs, young @entity0 . Clinical trials suggest a survival benefit from the direct portal administration of the @entity6 in the immediate post-operative period, although the magnitude of the effect is less than that seen in the systemic therapy trials.

title: [Recent advances in adjuvant chemotherapy in XXXX ].

answer: @entity5


abstract: UNASSIGNED: @entity4 ( @entity4 ) and @entity5 ( @entity5 ) are associated with functional beta cell loss due to ongoing @entity2 . Despite shared similarities, @entity4 is an @entity3 with evidence of autoantibody production, as well as a role for exocrine pancreas involvement. Our hypothesis is that differential protein expression occurs in disease stratified pancreas tissues and regulated proteins from endocrine and exocrine tissues are potential markers of disease and potential therapeutic targets. The study objective was to identify novel proteins that distinguish the pancreas from donors with @entity4 from the pancreas from @entity0 with @entity5 , or autoantibody positive non-diabetic donors. Detailed quantitative comprehensive proteomic analysis was applied to snap frozen @entity0 pancreatic tissue lysates from organ donors without @entity1 , with @entity4 -associated autoantibodies in the absence of @entity1 , with @entity4 , or with @entity5 . These disease-stratified @entity0 pancreas tissues contain exocrine and endocrine tissues (with dysfunctional islets) in the same microenvironment. The expression profiles of several of the proteins were further verified by western blot. We identified protein panels that are significantly and uniquely upregulated in the three disease-stratified pancreas tissues compared to non-disease control tissues. These proteins are involved in @entity2 , metabolic regulation, and autoimmunity, all of which are pathways linked to, and likely involved in, T1 and T2 @entity1 pathogenesis. Several new proteins were differentially upregulated in prediabetic, @entity4 , and @entity5 pancreas. The results identify proteins that could serve as novel prognostic, diagnostic, and therapeutic tools to preserve functional islet mass in Type 1 @entity1 .

title: Proteomic Analysis of Disease Stratified XXXX Pancreas Tissue Indicates Unique Signature of Type 1 @entity1 .

answer: @entity0


abstract: BACKGROUND: @entity1 ( @entity1 ) or minor @entity5 represents the largest group of @entity3 , and those @entity0 have a high risk of early recurrent @entity2 . Over decades, anticoagulation therapy has been used prudently in them for likely increasing the risk of @entity6 . However, recently @entity8 , a new oral anticoagulant, is proved to be as effective as traditional anticoagulants, while carrying significantly less risk of @entity7 . Therefore, we assumed that @entity0 may benefit from @entity8 if treated soon after @entity1 or @entity2 , and designed this adequately powered randomized study, TRACE. METHODS AND DESIGN: The Treatment of @entity8 versus @entity4 in Non-disabling Cerebrovascular Events (TRACE) study is a randomized, double-blind clinical trial with a target enrollment of 4400 @entity0 . A 14-days regimen of @entity8 10  mg daily or a 14-days regimen of @entity4 100  mg daily will be administrated to randomized @entity0 with acute @entity1 or @entity2 , defined as National Institute of Health Stroke Scale scores  <=3. The primary efficacy end point is percentage of @entity0 with any @entity2 ( @entity6 ) at 14  days. Study visits will be performed at the day of randomization, day 14 and day 90. DISCUSSION: Even though the new oral anticoagulants seem to be both safe and effective, few clinical trials have been carried out to test their effect on non-disabling cerebrovascular events. Treatment with @entity8 may prevent more cerebrovascular events with an acceptable risk profile after @entity1 or @entity2 , compared with @entity4 , thus helping to improve the outcome of the disease. TRIAL REGISTRATION: No. NCT01923818.

title: Treatment of XXXX versus @entity4 for Non-disabling Cerebrovascular Events (TRACE): study protocol for a randomized controlled trial.

answer: @entity8


abstract: OBJECTIVE: To describe the serum @entity3 profile and evaluate the adrenal response in @entity0 with @entity2 , and determine the influence of these factors on the outcome and mortality in this group. METHODS: Between May and November 2003, 22 @entity0 with @entity2 admitted to two pediatric intensive care units in southern Brazil were followed. Adrenal function was evaluated based on the levels of @entity3 measured on the occasion of the diagnosis of @entity2 and on the response of serum @entity3 30 min after the administration of intravenous @entity5 (0.5 microg/1.73m(2)). @entity4 was defined as a baseline serum @entity3 below 690 nmol/l and/or a @entity3 response to corticotrophin less than 250 nmol/l. RESULTS: @entity4 was detected in 17 @entity0 (77.3%). All @entity0 who died had baseline @entity3 higher than 690 nmol/l. A @entity3 response to corticotrophin less than 250 nmol/l was associated with a 60% mortality (RR = 7.2, 1.03-50.28). Regression analysis showed that the combination of baseline @entity3 higher than 690 nmol/l and a @entity3 response to corticotrophin less than 250 nmol/l were associated with mortality after correction for gender and PRISM. CONCLUSIONS: @entity4 is a frequent finding in @entity0 with @entity2 . The low-dose corticotrophin stimulation test seems to be an important tool to distinguish between a normal @entity3 response to stress and evidence of @entity1 . Mortality was significantly higher in @entity0 that failed to respond to a corticotrophin stimulation test.

title: Adrenal response in @entity0 with XXXX .

answer: @entity2


abstract: BACKGROUND: High-potency statins reduce @entity2 after @entity6 but remain underused in clinical practice. We examined predictors of nonuse of high-potency statins after @entity6 . METHODS AND RESULTS: The Stabilization of pLaques usIng Darapladib-Thrombolysis in @entity4 (SOLID-TIMI 52) trial enrolled @entity0 after an @entity6 in 36 countries between 2009 and 2011. Statin use was strongly encouraged throughout the trial, and statin potency was at the discretion of the treating physician. A high-potency statin was defined as >= 40  mg @entity7 , >= 20  mg @entity9 , or 80  mg @entity8 daily. Predictors of nonuse of high-potency statins were examined using logistic regression. Of the @entity0 included (n=12  446), 11  850 (95.2%) were treated with a statin at baseline after @entity6 (median 14  days), but only 5212 (41.9%) were on a high-potency statin. Selected @entity0 factors associated with nonuse of high-potency statins included age >= 75  years (odds ratio 1.39, 95% CI 1.24-1.56), female sex (odds ratio 1.11, 95% CI 1.02-1.22), @entity1 (odds ratio 1.17, 95% CI 1.03-1.32), and @entity5 during hospital admission (odds ratio 1.43, 95% CI 1.27-1.62). At 3  months after baseline, only 49% of @entity0 had low-density lipoprotein @entity3 <70  mg/dL. Among the 5490 @entity0 (59%) who were not on a high-potency statin at 3  months, lower low-density lipoprotein @entity3 was a predictor of nonuse of a high-potency statin after a median of 2.3  years (odds ratio 1.15 for 10  mg/dL decrease, 95% CI 1.11-1.19). CONCLUSION: Despite the widespread use of statins after @entity6 , most @entity0 are not treated with high-potency statins early and late after the event, including @entity0 at the highest risk of recurrent @entity2 . CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01000727.

title: Predictors of Nonuse of a High-Potency Statin After an Acute Coronary Syndrome: Insights From the Stabilization of Plaques Using Darapladib-Thrombolysis in XXXX 52 (SOLID-TIMI 52) Trial.

answer: @entity4


abstract: PURPOSE: The purpose of this study was to assess and compare health-related quality of life (HRQoL) and emotional well-being in mothers and fathers of @entity0 with drug-resistant @entity2 , referred for presurgical evaluation in Sweden. METHODS: Mothers (n=117) and fathers (n=102) of 122 @entity0 (0-18years) completed the generic 36-item Short Form Health Survey (SF-36) and the Hospital Anxiety and @entity3 Scale (HADS). Mothers' and fathers' SF-36 scores were compared with age-adjusted Swedish population values using the independent t-tests. Differences in the proportions of mothers vs. fathers classified as 'noncases' or 'possible/probable' clinical cases of @entity3 (HADS-D), respectively, were assessed with the chi-square test. Parents' HADS scores were also compared using independent t-tests. RESULTS: Mothers had significantly lower scores compared with norms on 6 of the 8 SF-36 domains (p<0.01), while fathers had significantly lower scores on 4 of the domains (p<0.01). Mothers had significantly lower scores than fathers on 4 of the SF-36 domains (p<0.05). Significantly more mothers than fathers scored below the population mean for the SF-36 Mental Component Summary score. A significantly larger proportion of mothers than fathers had 'possible/probable' @entity1 (52% vs. 38%) but not @entity3 (30% vs. 22%). Mothers had significantly worse scores than fathers on HADS-A (p<0.01) but not on HADS-D. CONCLUSION: Mothers and fathers of @entity0 with drug-resistant @entity2 have diminished HRQoL compared with population norms. Symptoms of @entity1 appear to be more common than symptoms of @entity3 . Mothers experienced higher levels of @entity1 , but not @entity3 , than fathers and scored lower than fathers on vitality, mental health, and Mental Component Summary of the SF-36. There is a need to identify contributory factors and interventions to ameliorate these difficulties.

title: Health-related quality of life and emotional well-being in parents of @entity0 with XXXX referred for presurgical evaluation in Sweden.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is characterised by functional impairment, @entity1 , and degeneration of specific neuronal populations, especially pyramidal neurones of the cerebral cortex and hippocampal formation. Although @entity0 with @entity6 have been shown to have similar metabolic and volumetric deficits to those with @entity2 , the underlying pathogenesis of these changes is poorly understood. OBJECTIVE: To determine whether pyramidal cell loss occurs in @entity8 ( @entity8 ) @entity3 by quantifying hippocampal volume and @entity7 neurone number. METHODS: Fifty four prospectively studied @entity0 with @entity3 were screened, and four @entity0 fulfilling criteria for @entity8 with no other significant @entity5 were identified. These were compared with five @entity0 fulfilling criteria for @entity2 and seven controls matched for age and sex. The hippocampal formation was serially sectioned, and the number of @entity7 pyramidal neurones estimated using the optical dissector technique. Analysis of variance was used to evaluate group differences. RESULTS: @entity0 in both the @entity2 and @entity8 groups showed a substantial loss of pyramidal neurones from the @entity7 region. The pattern of hippocampal @entity1 and the degree of @entity7 @entity4 were similar in the two @entity3 groups. CONCLUSIONS: These findings support recent in vivo studies showing similar metabolic deficits and @entity1 in @entity2 and @entity6 . In addition, they provide evidence that the underlying cause of these abnormalities is a similar loss of neurones. Whereas the cause of the @entity4 in @entity2 is related to the deposition of abnormal proteins, the cause in @entity8 is unknown. In the absence of other pathologies, damage to cerebral microvasculature should be considered a likely candidate.

title: @entity0 with XXXX due to microvascular pathology have significant hippocampal @entity4 .

answer: @entity6


abstract: BACKGROUND: Local anesthetics are commonly used in the @entity3 ( @entity3 ). @entity9 can lead to disastrous complications including @entity8 and arrest. Recognition of local anesthetic systemic @entity2 (LAST) is important; however, prevention is even more critical. Knowledge of proper @entity10 dosage can prevent LAST. LAST may be effectively treated with lipid emulsion therapy. Although the mechanism is not well understood, its use may have a profound impact on morbidity and mortality. CASE REPORT: Fifty milliliters of 2% @entity10 was infiltrated for local anesthesia in a 35-year-old @entity0 during the incision and drainage of a @entity6 . Following the procedure, the @entity0 @entity4 , with rapid progression to an altered mental state and @entity5 requiring endotracheal intubation for airway protection. Suspecting @entity10 @entity2 , intralipids were ordered. While waiting for the intralipids, the @entity0 decompensated and suffered pulseless electrical activity ( @entity11 ) @entity7 . A 100-mL bolus of 20% intralipids was administered 3 minutes into the resuscitation, after which return of spontaneous circulation occurred. The intralipid bolus was then followed by a continuous infusion of 0.25 mL/kg/minute, for an infusion dose of 930 mL. Despite a complicated hospital course, the @entity0 was discharged home neurologically intact. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: We believe this @entity0 's @entity1 was secondary to an iatrogenic @entity9 of @entity10 . This is one of the first cases to support the efficacy of intravenous lipids in the treatment of LAST in @entity0 in the @entity3 .

title: @entity10 -Induced XXXX in the Emergency Department: Effectiveness of Lipid Therapy.

answer: @entity7


abstract: The aim was to describe the clinical orthopedic implications of oligofructose overload. A group of 8 nonpregnant dairy heifers were given an oral dose of @entity7 (17 g/kg of body weight). At predefined times during a period spanning 3 d before and 9 d after oligofructose overload, the heifers underwent a clinical examination including locomotion scoring, hoof-testing, and palpation of tarso-crural joints, as well as the collection of blood and ruminal fluid samples. Locomotion sessions were videotaped; subsequently, locomotion was blind-scored. Locomotion scores increased after oligofructose overload and declined toward the end of the study period. The greatest locomotion scores were recorded on d 3 to 5 (60 to 120 h) where 12 of 42 (29%) locomotion scores were 3 and 13 of 42 (32%) were score 2. Positive reactions to hoof-testing were observed from 30 h after oligofructose overload and reached a maximum on d 7 and 9 where 12 of 28 (43%) reactions were marked positive. @entity6 was observed from 24 h after oligofructose overload, with maximum distension being observed on d 2, in which 44 of 56 (79%) of observed joints were either moderately or severely distended. The heifers developed classic signs of acute ruminal and systemic @entity3 after the oligofructose overload (ruminal pH 4.3 +/- 0.07, standard base excess -10.8 +/- 2.3 at 18 h). With few exceptions, clinical and laboratory variables returned to normal within 9 d of oligofructose overload. But, good body condition and previous feeding with grass apparently predisposed the heifers to more severe systemic affection. Oligofructose overload in dairy heifers induced ruminal and systemic @entity3 , @entity2 , @entity5 , and, subsequently, @entity4 , @entity0 , and joint effusion, collectively interpreted as signs of acute laminitis. Oligofructose overload at 17 g/kg of body weight represented a relatively mild laminitis model in @entity1 , as demonstrated by a reasonably quick recovery from systemic as well as orthopedic signs.

title: XXXX overload induces @entity4 in @entity1 .

answer: @entity7


abstract: BACKGROUND: Stiffening of large arteries can result in changes of cardiac structure and function by increasing afterload to the left ventricle. Calcification has been proposed as a mechanism underlying progression of arterial stiffening. The aim of the current study was to investigate the relationship between @entity4 , arterial stiffening, @entity6 , and @entity1 . METHODS: One hundred and sixty-four @entity2 elderly (>= 65 years old) male @entity0 with normal left ventricular systolic function (left ventricular ejection fraction >= 55%) underwent transthoracic echocardiography, brachial-ankle pulse wave velocity (baPWV), and noncontrast computed tomography. Coronary artery @entity3 score and aorta @entity3 score (ACS) were measured on noncontrast computed tomography using the volume method. Left ventricular dimensions, mitral inflow velocities, and early mitral annular (E') velocity were measured using transthoracic echocardiography. The left ventricular mass index (LVMI) was calculated. RESULTS: The logACS was associated with mean baPWV (r=0.387, P=0.001), LVMI (r=0.241, P<0.002), E' velocity (r=-0.293, P<0.001), and E/E' (r=0.194, P=0.013), suggesting arterial stiffening, increased left ventricular mass, and @entity1 in @entity0 with raised ACS. On multivariate analysis, the LVMI showed an independent positive association with the logACS, even after adjusting for various clinical variables and the coronary artery @entity3 score (P=0.009). Similarly, E' velocity also demonstrated an independent negative association with the logACS on multivariate analysis (P=0.003). The mean baPWV, LVMI, and E' velocity showed similar correlations with both @entity5 and abdominal ACS, even when @entity5 and abdominal @entity3 scores were calculated separately. CONCLUSION: Heavy @entity4 and resultant arterial stiffening might underlie @entity6 and @entity1 in elderly male @entity0 with @entity2 .

title: @entity4 is associated with arterial stiffening, @entity6 , and @entity1 in elderly male @entity0 with XXXX .

answer: @entity2


abstract: OBJECTIVES: The purpose of this study was to investigate associations between use of @entity3 ( @entity3 ) agonist drugs during pregnancy and risk for @entity1 ( @entity1 ). METHODS: A case-control study was conducted by using Denmark's health and population registers. Among @entity0 born between 1997 and 2006, 5200 cases with @entity1 admission diagnoses and 52   000 controls without @entity1 were identified and individually matched on month and year of birth. Conditional logistic regression models were used to estimate odds ratios (OR) and confidence intervals (CI) for any @entity3 agonist exposure during pregnancy, preconception, and by trimester. RESULTS: In total, 3.7% of cases and 2.9% of controls were exposed to B2ARs during pregnancy. Use of B2ARs during pregnancy was associated with increased risk of @entity1 , even after adjustment for maternal @entity2 and other covariates (OR: 1.3, 95% CI: 1.1-1.5). The elevated risk was observed with use of @entity3 during preconception (OR: 1.3, 95% CI: 1.0-1.6), first trimester (OR: 1.3, 95% CI: 1.1-1.5), second trimester (OR: 1.5, 95% CI: 1.1-1.7), and the third trimester (OR: 1.4, 95% CI: 1.1-1.7). There was some evidence that longer @entity3 within-pregnancy use was associated with the increased risk. CONCLUSIONS: @entity3 agonist exposure during pregnancy may be associated with an increased risk for @entity1 . If the effect is real, any intervention must be balanced against benefits of indicated medication use by pregnant @entity0 .

title: In utero Exposure to XXXX Agonist Drugs and Risk for Autism Spectrum Disorders.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: The effect of increased fluid intake on kidney function is unclear. This study evaluates the relationship between urine volume and renal decline over 6 years in a large community-based cohort. DESIGN, SETTING, @entity0 , _ MEASUREMENTS: This prospective cohort study was undertaken in Canada from 2002 to 2008. We obtained 24-hour urine samples from adult @entity0 with an estimated @entity5 (eGFR) >= 60 ml/min per 1.73 m(2) at study entry. Percentage annual change in eGFR from baseline was categorized as average decline <1% per year, between 1% and 4.9% (mild-to-moderate decline) or >= 5% (rapid decline). RESULTS: 2148 @entity0 provided valid 24-hour urine samples, grouped as <1 L/d (14.5%); 1 to 1.9 L/d (51.5%); 2 to 2.9 L/d (26.3%); and >= 3 L/d (7.7%). Baseline eGFR for each category of urine volume was 90, 88, 84, and 87 ml/min per 1.73 m(2), respectively. Overall, eGFR declined by 1% per year, with 10% demonstrating rapid decline and 40% demonstrating mild-to-moderate decline. An inverse, graded relationship was evident between urine volume and eGFR decline: For each increasing category of 24-hour urine volume, percentage annual eGFR decline was progressively slower, from 1.3%, 1.0%, 0.8%, to 0.5%, respectively; P = 0.02. Compared with those with urine volume 1 to 1.9 L/d, those with urine volume >= 3 L/d were significantly less likely to demonstrate mild-to-moderate decline (adjusted odds ratio 0.66; 95% confidence interval 0.46 to 0.94) or rapid decline (adjusted odds ratio 0.46; 95% confidence interval 0.23 to 0.92); adjusted for age, gender, baseline eGFR, medication use for @entity3 (including diuretics), @entity4 , @entity1 , and @entity2 . CONCLUSIONS: In this community-based cohort, decline in kidney function was significantly slower in those with higher versus lower urine volume.

title: Urine volume and change in estimated XXXX in a community-based cohort study.

answer: @entity5


abstract: OBJECTIVES: The initial management of a @entity2 @entity0 often involves imaging in the form of x-rays, computed tomography (CT) and other radiographic studies, which expose the @entity0 to ionizing radiation, an entity known to cause tissue injury and @entity1 at high doses. The purpose of this study was to use a calculation-based method to determine the radiation exposure of @entity2 @entity0 undergoing @entity2 team activation in a Canadian tertiary-care @entity2 centre. METHODS: A retrospective chart review was conducted using the Nova Scotia Provincial @entity2 Registry. All @entity0 age 16 years old and over who underwent @entity2 team activation between @entity4 , 2008 and @entity4 , 2009 were included. @entity0 who died prior to imaging tests were excluded. Dose reports for each CT were used to calculate a whole-body radiation dose for each @entity0 . RESULTS: There were 230 @entity2 team activations during the study period, of which 206 had CT imaging. Data were available for 162 @entity0 . The mean whole-body radiation exposure for all @entity0 was 24.4  10.3 @entity3 , which may correlate to one additional @entity1 death for every 100 @entity2 @entity0 scanned. CONCLUSIONS: @entity2 @entity0 are exposed to significant amounts of radiation during their initial @entity2 work-up, which may increase the risk of fatal @entity1 . Clinicians who care for these @entity0 must be aware of the radiation exposure, and take measures to limit radiation exposure of @entity2 @entity0 .

title: Radiation Exposure From CT Scanning in the Resuscitative Phase of @entity2 Care: A Level One XXXX Centre Experience.

answer: @entity2


abstract: OBJECTIVES: To determine the most effective pharmacological intervention and to bring recommendations for decision-making in the management of adults with @entity2 with @entity1 . METHODS: A clinical practice guideline was elaborated under the parameters of the Methodological Guide of the Ministerio de Salud y Protecci  n Social to identify, synthesize and evaluate the evidence and make recommendations about the treatment and follow-up of adult @entity0 with @entity2 . The evidence of NICE guide 82 was adopted and updated. The evidence was presented to the Guideline Developing Group and recommendations, employing the GRADE system, were produced. RESULTS: It is recommended the use of parenteral drugs in all @entity7 @entity0 who does not respond to the measures of persuasion. The drugs with better evidence on effectiveness (control of violent behavior) are @entity6 and @entity4 , administered jointly or individually. @entity3 is also an option considering that should only be used in institutions where a psychiatrist is available 24hours. @entity5 can be considered as a second-line drug. The information about the side effects associated with these drugs is insufficient and has low quality. CONCLUSION: Violent behavior in adults with @entity2 represents a risk for themselves and for those around them, so the opportune implementation of interventions aimed to calm the @entity0 , in order to prevent potential negative outcomes is necessary. It is recommended to initiate these interventions with measures of verbal persuasion, and if these measures are not effective, appropriate use of parenteral drugs: @entity6 and @entity4 as first-line and @entity3 and @entity5 as second choices.

title: [Pharmacological Treatment for Adult Diagnosed With @entity2 With XXXX or Violent Behavior].

answer: @entity7


abstract: OBJECTIVE: To perform a systematic review and meta-analysis to study the magnitude of the placebo effect associated with sham surgery procedures. STUDY DESIGN AND SETTING: We conducted a systematic search for randomized controlled clinical trials comparing any type of surgery to a corresponding sham placebo group and compared improvements in the sham treatment arms in subjective, objective, categorical, and continuous outcomes, as well as complication rates and mortality. Effect sizes were reported as standardized mean differences (SMDs). This is a systematic review and meta-analysis. RESULTS: The overall effect size for @entity1 improvement after sham surgery was @entity2  =  0.22 (95% confidence interval [CI]  =  0.08-0.35) with improvement most marked at 1 month ( @entity2  =  0.34, 95% CI  =  0.26-0.43). There was a higher rate of improvement in subjective outcomes compared to objective outcomes for both dichotomized (number of @entity0 with improvement) (42.8% compared to 27.1%) and continuous outcomes ( @entity2  =  0.12, 95% CI  =  -0.05, 0.30 vs. @entity2  =  -0.01, 95% CI  =  -0.05, 0.03). There were no deaths in the sham treatment arms and major complications were very rare (0.2%, 95% CI  =  0.0-0.6%). CONCLUSION: Sham surgery is associated with a large improvement in @entity1 and other subjective @entity0 -reported outcomes but with relatively small effect on objective outcomes. Sham surgeries are overwhelmingly safe. The magnitude of this effect should be used when planning future sham-controlled surgery trials.

title: Sham surgical procedures for @entity1 intervention result in significant improvements in XXXX : systematic review and meta-analysis.

answer: @entity1


abstract: We recently reported the isolation of a unique subpopulation of @entity0 stromal cells from bone marrow (BM) termed marrow-isolated adult multilineage inducible (MIAMI) cells, capable of differentiating in vitro into mature-like cells from all three germ layers. The @entity1 tension ( @entity4 ) in BM ranges from 1 to 7%, which prompted us to examine the role of @entity4 in regulating the capacity of MIAMI cells both to self-renew and maintain their pluripotentiality ( @entity3 ) or to progress toward osteoblastic differentiation. MIAMI cells were grown under low- @entity4 conditions (1, 3, 5, and 10% @entity1 ) or air (21% @entity1 ). The proliferation rate of cells exposed to 3% @entity1 (3 days) increased, resulting in cell numbers more than threefold higher than those of cells exposed to air (at 7 days). In cells grown under osteoblastic differentiation conditions, the expression of the osteoblastic markers osteocalcin, bone sialoprotein, @entity7 , and @entity6 and alkaline phosphatase activity was upregulated when incubated in air; however, it was blocked at low (3%) @entity4 . Similarly, biomineralization of long-term cell cultures was high under osteoblastic differentiation conditions in air but was undetectable at low (3%) @entity4 . In contrast, low @entity4 upregulated mRNAs for @entity5 , @entity8 , telomerase reverse transcriptase, and @entity2 -inducible factor-1 alpha, and increased the expression of SSEA-4 compared to air. Moreover, the expression of embryonic stem cell markers was sustained even under osteogenic culture conditions. Similar results were obtained using commercially available marrow stromal cells. We hypothesize a physiological scenario in which primitive MIAMI cells self-renew while localized to areas of low @entity4 in the bone marrow, but tend to differentiate toward osteoblasts when they are located closer to blood vessels and exposed to higher @entity4 . Our results strongly suggest that maintaining developmentally primitive @entity0 cells in vitro at low @entity4 would be more physiological and favor @entity3 over differentiation.

title: Low XXXX tension inhibits osteogenic differentiation and enhances @entity3 of @entity0 MIAMI cells.

answer: @entity1


abstract: @entity3 is a highly prevalent @entity0 disease in which @entity4 ( @entity4 ) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here, we show that the in vivo inactivation of all @entity4 family genes in the @entity2 urothelium is sufficient to initiate @entity3 development. The characterization of the @entity2 @entity1 revealed multiple molecular features of @entity0 @entity3 , including the activation of E2F transcription factor and subsequent @entity5 expression and the activation of several signaling pathways previously identified as highly relevant in @entity1 . These @entity2 represent a genetically defined model for @entity0 high-grade superficial @entity3 . Whole transcriptional characterizations of @entity2 and @entity0 @entity3 revealed a significant overlap and confirmed the predominant role for @entity5 in the downregulation of gene expression programs. Importantly, the increased @entity1 recurrence and progression in @entity0 @entity0 with superficial @entity3 is associated with increased E2F and @entity5 expression and @entity5 -mediated gene expression repression. Collectively, our studies provide a genetically defined model for @entity0 high-grade superficial @entity3 and demonstrate the existence of an @entity4 -E2F- @entity5 axis in bladder whose disruption can promote @entity1 development. @entity1 Res; 74(22); 1-13.   2014 AACR.

title: In Vivo Disruption of an @entity4 -E2F- @entity5 Signaling Loop Causes XXXX .

answer: @entity3


abstract: Constipation is a common childhood complaint. In 90% to 95% of @entity0 , @entity11 is functional, which means that there is no objective evidence of an underlying pathological condition. @entity8 ( @entity9 or @entity8 ) solution is an osmotic laxative agent that is absorbed in only trace amounts from the gastrointestinal tract and routinely used to treat chronic @entity11 in adults. Here, we report the results of a meta-analysis of @entity9 -based laxatives compared with @entity13 , milk of magnesia ( @entity14 ), oral liquid @entity10 (mineral oil), or acacia fiber, @entity15 fiber, and @entity7 in @entity0 . This meta-analysis was conducted in accordance with PRISMA guidelines and involved searches of MEDLINE, Cochrane, EMBASE, and Google Scholar databases up to February 10, 2014, using the keywords (Constipation OR Functional Constipation OR Fecal Impaction) AND ( @entity0 ) AND ( @entity8 OR Laxative). Primary efficacy outcomes included a number of stool passages/wk and percentage of @entity0 who reported satisfactory stool consistency. Secondary safety outcomes included @entity2 , @entity5 , @entity3 or @entity4 , @entity1 or straining at defecation, @entity12 or flatulence, hard stool consistency, poor palatability, and @entity6 . We identified 231 articles, 27 of which were suitable for full-text review and 10 of which were used in the meta-analysis. @entity0 who were treated with @entity9 experienced more successful disimpaction compared with those treated with non- @entity9 laxatives. Treatment-related adverse events were acceptable and generally well tolerated. @entity9 -based laxatives are effective and safe for chronic @entity11 and for resolving fecal impaction in @entity0 . @entity0 's acceptance of @entity9 -based laxatives appears to be better than non- @entity9 laxatives. Optimal dosages, routes of administration, and @entity9 regimens should be determined in future randomized controlled studies and meta-analyses.

title: Efficacy and complications of @entity8 for treatment of @entity11 in XXXX : a meta-analysis.

answer: @entity0


abstract: PURPOSE: To report a series of consecutive cases for which a lotrafilcon A @entity3 hydrogel soft contact lens was used in therapeutic applications. METHODS: Three practitioners in Spain, Denmark, and Germany supplied 41 consecutive case reports of 39 @entity0 for whom a lotrafilcon A @entity3 hydrogel soft contact lens was used in therapeutic applications. Applications included @entity5 , @entity4 , @entity6 , @entity8 , @entity7 , entropion, and use after corneal surgeries. Practitioners reported their judgments of @entity2 relief, change in corneal signs by slitlamp evaluation, additional complications, and success of therapeutic lens treatment. Twenty cases of completed treatment and 21 cases of ongoing treatment were reported. RESULTS: Complete @entity2 relief was reported for 78% of all cases, with 94% of all cases reporting @entity2 relief of 50% or higher. Corneal signs were restored to normal for 74% of all cases, with 100% of all cases showing at least partial improvement. No additional complications were reported in 83% of all cases. Therapeutic contact lens application was judged fully successful for 71% of all cases, with 93% of all cases showing at least partial improvement. CONCLUSION: The high- @entity1 permeable (Dk) lotrafilcon A lens met or exceeded the outcomes reported from historic reports of therapeutic applications of low-Dk soft contact lenses. Although the case reporting conditions vary among the historic studies and from the current study, this study indicates that success may be improved with the lotrafilcon A high-Dk lens.

title: Retrospective case series of therapeutic applications of lotrafilcon a XXXX hydrogel soft contact lenses.

answer: @entity3


abstract: OBJECTIVE: This study sought to evaluate the @entity2 and curative effect of @entity8 plus @entity4 neoadjuvant chemotherapy (NACT) for stage @entity9 , IIa2, and IIb @entity1 @entity0 . METHODS: A total of 219 @entity0 were randomly assigned to two groups: 109 @entity0 were treated with 1-2 cycles of chemotherapy (NACT group), and 110 @entity0 in the control group were treated directly with surgery (DS group). @entity0 in the NACT group were randomly assigned to two groups: 50 @entity0 were treated with @entity8 plus @entity4 followed by surgery (IP group), and 59 @entity0 were treated with @entity5 plus @entity4 followed by surgery (TP group). @entity0 with pathological recurrence risk factors received post-operative radiotherapy. RESULTS: Survival analysis revealed no significant difference in disease-free survival (DFS) or @entity6 ( @entity6 ) between the NACT and DS groups. Analysis of clinicopathologic factors showed that the lymphovascular space invasion (LVSI) and deep stromal invasion rates were significantly lower in the NACT group. Grade 3/4 @entity7 and grade 3/4 @entity3 were both higher in the IP group than in the TP group. DFS and @entity6 were similar in the IP and TP groups. Univariate analysis showed that LVSI was the only factor associated with DFS. CONCLUSION: NACT did not improve @entity6 but did reduce the number of @entity0 who received post-operative radiotherapy. NACT consisting of @entity8 plus @entity4 for @entity1 showed similar efficacy and higher @entity2 compared with the use of @entity5 plus @entity4 , although the @entity2 was tolerable.

title: The efficacy and safety of neoadjuvant chemotherapy in the treatment of locally advanced XXXX : A randomized multicenter study.

answer: @entity1


abstract: BACKGROUND: For anatomical and technical reasons, many transplant centers restrict laparoscopic live donor nephrectomy (in contrast with open live donor nephrectomy) to left kidneys. HYPOTHESIS: This change in surgical practice increases procurement and transplantation rates of live donor kidneys with @entity1 (RAs), without affecting donor and recipient outcomes. DESIGN AND SETTING: Retrospective review at an academic tertiary care referral center comparing laparoscopically procured single vs multiple-RA kidney grafts (April 1997 to October 2000). @entity0 : Seventy-nine consecutive left laparoscopic live kidney donors and 78 transplant recipients. MAIN OUTCOME MEASURES: Donor and recipient complications and postoperative length of stay; cold and warm @entity2 time; operating time; short-term and long-term graft function; and survival. RESULTS: We noted multiple RAs in 21 (27%) of all kidneys. The proportion of donors with 1 or more perioperative complications was 19% in the single-RA group vs 10% in the multiple-RA group (P was not significant). For the recipients, we noted no significant differences between groups with respect to surgical complications, quality of early and late graft function, rejection rates, graft losses (all immunologic), and graft survival. Cold and warm @entity2 time and length of stay were similar for donors and recipients in both groups. Median operating times were significantly longer for the multiple-RA vs single-RA group (difference, 41 minutes for donors and 45 minutes for recipients; P<.02). CONCLUSIONS: While the introduction of laparoscopic live donor nephrectomy has significantly increased the number of grafts with multiple RAs (compared with historical open controls), this change in practice is safe for both donors and recipients from a @entity0 outcome-based perspective. However, from an economic perspective, the longer operating time associated with multiple-RA grafts provides strong added rationale for optimization of surgical instruments and techniques to make right-sided laparoscopic nephrectomy a routine intervention.

title: @entity1 with XXXX in the laparoscopic live donor nephrectomy era: surgical technique and surgical and nonsurgical donor and recipient outcomes.

answer: @entity1


abstract: Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used in the treatment of @entity2 , @entity5 , @entity7 , @entity0 , @entity3 , and other diseases caused by retention of phlegm dampness. In this study we investigated the potential mechanism of ECD, using metabolism-disabled @entity1 induced by high-fat diet. Body weight and abdominal circumference were detected. OGTT was measured by means of collecting blood samples from the tail vein. Blood lipid levels and insulin were measured using biochemical assay kit. Real-time PCR was used to measure the @entity8 gene expression and western blot was used to measure the protein expression. Through the research, it was found that ECD showed markedly lower body weight and abdominal circumference than those in the HFD group. Consistently, we observed that ECD significantly improved @entity6 tolerance, promoted the secretion of insulin and decreased the level of TG, TC level. Meanwhile, we observed significantly increased @entity8 mRNA and protein level in the ECD group. Therefore, we speculate that the potential molecular mechanism of ECD is to promote the @entity8 expression, ameliorate islet cell function, and raise insulin levels to regulate the @entity4 .

title: Erchen Decoction Prevents High-Fat Diet Induced XXXX in C57BL/6 @entity1 .

answer: @entity4


abstract: We investigated the impact of molecular mimicry between pathogenic microbes and their antigenic surrounding on the clinical course and outcome of @entity2 induced @entity3 . Using mathematical prediction, we estimated the mimicry tendency of the identified pathogenic flora of @entity0 with the @entity0 proteome as well as intestinal microbes. Since gut bacteria become invasive and hostile in @entity5 , mimicry between these organisms and the infectious flora is expected to be rather hyperinflammatory type, in contrast to the expectedly tolerogenic self versus pathogen cross-reactions. Differential effects of these two kinds of cross-reactions were studied. The predicted similarity of the identified pathogenic flora and intestinal microbes was higher in non-survivor @entity0 compared to survivors (P=0.019). Higher values of "pathogen versus intestinal flora/pathogen versus @entity0 proteome" mimicry ratios (inflammatory quotients) were associated with mortality at a higher extent of significance (P<0.01), and correlated with admission APACHE II disease severity scores (R=0.311; P=0.017). We also found a correlation between the previously reported @entity3 mortality rates by causative agent and the corresponding inflammatory quotients of these pathogens (R=0.738; P<0.05). Gram negative species showed higher similarity to intestinal bacteria and reached higher inflammatory quotients compared to Gram positives (P=0.01 and P<0.01, respectively). The disadvantageous effect of "pathogen versus intestinal flora" mimicry - presumably due to the extension of @entity1 from the infectious focus to the already injured gut - is in accordance with the gut-lymph hypothesis, assessing that the destruction of the intestinal symbiosis culminates in the formation of damageous gut origin lymph. Our results raise the idea that molecular mimicry between pathogenic microbes and their antigenic surrounding might be a contributing factor behind the clinically and experimentally observed differences in microbiologically distinct forms of @entity4 .

title: Impact of molecular mimicry on the clinical course and outcome of XXXX .

answer: @entity4


abstract: The complementary action of angiotensin converting enzyme inhibitors and diuretics in the treatment of @entity3 has been demonstrated in a number of studies of @entity11 and @entity6 ( @entity6 ). The combination provides a clinically significant reduction in blood pressure while minimizing the dose-dependent adverse effects of @entity6 , such as @entity4 and its metabolic effects on plasma lipoproteins, by keeping the dose of each agent to the minimum. @entity11 has a unique dual mechanism of elimination and can therefore be used in @entity0 with @entity2 . The efficacy of the combination of @entity11 and @entity6 compared with placebo and other agents is reviewed in this article. Studies have demonstrated that the combination is effective in the elderly and in @entity2 @entity0 , regardless of severity. In addition, in @entity9 , antihypertensive effect is achieved without further affecting @entity8 and lipid metabolism, which is often the case when @entity10 diuretics alone are used. A matrix study was performed to evaluate the optimum dose combination to produce blood pressure normalization and minimize side effects. This study evaluated 17 different dose combinations and demonstrated that the lowest dose combination to produce a clinically significant effect was @entity11 10 mg and @entity6 12.5 mg. However, a dose-related antihypertensive effect can be seen, giving the option for the use of 20 mg @entity11 for moderately @entity3 @entity0 . Both combination therapy and @entity11 were significantly more effective than @entity6 alone or placebo. The @entity11 / @entity6 combination has also been shown to have a comparable effect to sustained-release @entity5 and @entity7 + @entity6 . The studies reviewed here demonstrate that @entity11 / @entity6 combination treatment has a number of advantages over either agent used alone, providing blood pressure normalization in a broad range of @entity3 @entity0 , including @entity1 @entity0 and the elderly.

title: Management of XXXX : the role of combination therapy.

answer: @entity3


abstract: @entity4 ( @entity4 ) is a highly successful procedure for voice restoration. Occasionally, however, @entity0 fail to achieve satisfactory voice or develop salivary leakage through the @entity1 into the @entity3 . Closure of the @entity4 is then necessary. In most cases, spontaneous closure occurs once the prosthesis has been removed. When the @entity1 does not close spontaneously, surgical closure is indicated to prevent @entity2 . We describe a three-layer technique that employs interposition of dermal graft. The technique was used on 14 @entity0 over a 7-year period. Most @entity0 received irradiation to the neck. Complete closure was achieved in 13 of 14 cases; 1 @entity0 developed partial breakdown of the closure. Our technique is relatively easy to perform and has a high success rate (92%). Irradiation did not adversely affect the closure rate.

title: Surgical closure of persisting failed XXXX .

answer: @entity4


abstract: OBJECTIVE: For individuals with 1-2 small (<1   cm) low-risk @entity5 , international guidelines range from no surveillance to offering surveillance colonoscopy in 5-10   years. We hypothesised that the risks for @entity4 ( @entity4 ) among @entity0 with low-risk @entity1 differ based on clinical factors distinct from those currently used. DESIGN: We pooled data from seven prospective studies to assess the risk of metachronous @entity4 . Two groups with 1-2 small @entity1 were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). RESULTS: Absolute risk of metachronous @entity4 ranged from a low of 2.9% to a high of 12.2%, depending on specific risk factor and guideline used. For the UK group, the highest absolute risks for metachronous @entity4 were found among individuals with a history of prior @entity2 (12.2%), villous histology (12.2%), age >= 70   years (10.9%), high-grade @entity3 (10.9%), any proximal @entity1 (10.2%), distal and proximal @entity1 (10.8%) or two @entity1 (10.1%). For the EU/US group, the highest absolute risks for metachronous @entity4 were among individuals with a history of prior @entity2 (11.5%) or the presence of both proximal and distal @entity1 (11.0%). In multivariate analyses, strong associations for increasing age and history of prior @entity2 and odds of metachronous @entity4 were observed, whereas more modest associations were shown for baseline proximal @entity1 and those with villous features. CONCLUSIONS: Risks of metachronous @entity4 among individuals with 1-2 small @entity1 vary according to readily available clinical characteristics. These characteristics may be considered for recommending colonoscopy surveillance and require further investigation.

title: Risk stratification of individuals with low-risk XXXX using clinical characteristics: a pooled analysis.

answer: @entity5


abstract: BACKGROUND: This phase III trial compared the efficacy and safety of @entity1 plus @entity3 (GemCap) versus single-agent @entity1 ( @entity7 ) in advanced @entity4 as first-line chemotherapy. METHODS: A total of 214 advanced @entity4 @entity0 were enrolled from 16 hospitals in South Korea between 2007 and 2011. @entity0 were randomly assigned to receive GemCap (oral @entity3 1660mg/m plus @entity7 1000mg/m by 30-minute intravenous infusion weekly for 3 weeks followed by a 1-week break every 4 weeks) or @entity7 (by 30-minute intravenous infusion weekly for 3 weeks every 4 weeks). RESULTS: Median @entity5 ( @entity5 ) time, the primary end point, was 10.3 and 7.5 months in the GemCap and @entity7 arms, respectively (P=0.06). Progression-free survival was 6.2 and 5.3 months in the GemCap and @entity7 arms, respectively (P=0.08). GemCap significantly improved overall response rate compared with @entity7 alone (43.7% vs 17.6%; P=0.001). Overall frequency of grade 3 or 4 @entity2 was similar in each group. @entity6 was the most frequent grade 3 or 4 @entity2 in both groups. CONCLUSION: GemCap failed to improve @entity5 at a statistically significant level compared to @entity7 treatment. This study showed a trend toward improved @entity5 compared to @entity7 alone. GemCap and @entity7 both exhibited similar safety profiles.

title: A randomized, multicenter, phase III study of @entity1 combined with @entity3 versus @entity1 alone as first-line chemotherapy for advanced XXXX in South Korea.

answer: @entity4


abstract: BACKGROUND: Primary @entity2 with hepatocellular and cholangiocellular differentiation (b[HB]-PLC) are rare. Surgery offers the best prognosis, but there is a paucity of literature to guide therapy for @entity0 with advanced or unresectable disease. This study aimed to evaluate outcomes of hepatic-directed therapy compared with those of systemic chemotherapy and surgery. METHODS: A retrospective evaluation of @entity0 with b(HB)-PLC from 1 January 2008 to 1 September 2014 was conducted. The @entity0 were divided into the following four groups: transplantation (TX) group, surgical resection (SX) group, @entity3 ( @entity3 ) group, and systemic chemotherapy alone (SC) group. Overall and progression-free survival, treatment response, and clinicopathologic data were analyzed. RESULTS: The study included 79 @entity0 (37 females) with an average age of 62  years. The number of @entity0 in each group were as follows: TX group (n  =  6), SX group (n  =  27), @entity3 group (n  =  18), and SC group (n  =  28). The mean follow-up periods were 33  months for the TX group, 17  months for the SX group, 14  months for the @entity3 group, and 7  months for the SX group. Overall, 28  % of the @entity0 had @entity1 and 35  % had @entity3 . The candidates for surgery comprised 42  % of the @entity0 . The @entity3 group (n  =  18) had a significantly greater objective response than the SC group (n  =  28) (47 vs. 6  %; p  =  0.02). Two @entity0 who underwent hepatic arterial infusion pump treatment were downstaged to resection. A trend toward improved OS/PFS was observed in the @entity3 group versus the SC group, although statistically significant. The SX group had significantly improved survival (p  <  0.001) as did the transplanted @entity0 . CONCLUSIONS: Although surgery offers the best survival for b(HB)-PLC @entity0 , only a minority are candidates for surgery. Because @entity3 therapy showed a superior objective response over SC therapy, it may offer a survival advantage and may downstage @entity0 for surgical resection or transplantation.

title: Biphenotypic Primary XXXX : Assessing Outcomes of Hepatic Directed Therapy.

answer: @entity2


abstract: Microbubbles have been reported to enhance ultrasound (US)-related side effects in animal systems. The present study investigated the influence of contrast ultrasonography (US) with @entity3 lipid microspheres, a recently developed second-generation contrast agent, on microvessels. @entity0 mesentery was exposed to 1.8-MHz pulsed US with intravenous injection of @entity3 (0.1 or 1.0 ml/kg) or Levovist (300 mg/kg), and the microvessel @entity1 and endothelial cell injury was examined. Impaired endothelial cells were identified by the fluorescence of @entity2 . Microvessel @entity1 was examined also in the @entity0 myocardium. The interaction between 0.1 ml/kg of @entity3 and US exposure did not cause microvessel @entity1 , and did not increase endothelial cell injury compared with the sham operation, unless frequent, strong US exposure occurred. When the dose was increased to 1.0 ml/kg, the combination of @entity3 and US exposure resulted in @entity1 and increased endothelial cell injury in capillaries and venules (p<0.01). However, the incidence of microvessel @entity1 and endothelial cell injury did not exceed that with Levovist microbubbles. In the myocardium, microvessel @entity1 was not observed under any conditions. In conclusion, @entity3 lipid microspheres enhanced US-related microvessel injury as with other contrast agents at the dose of 1.0 ml/kg, but not with 0.1 ml/kg and the appropriate US setting.

title: Influence of contrast ultrasonography with XXXX lipid microspheres on microvessel injury.

answer: @entity3


abstract: CONTEXT: Immunohistochemical staining for @entity6 ( @entity6 ) is a useful ancillary technique for diagnosing @entity5 ( @entity2 ) in histologic specimens. Although similar results have been obtained on aspirate smears, to our knowledge the utility of @entity6 immunolocalization in cell block preparations as an adjunct to fine-needle aspiration diagnosis of @entity2 has not been examined. OBJECTIVE: The purpose of this study was to determine whether @entity6 immunostaining of cell block preparations of thyroid aspirates is a useful ancillary technique for diagnosing @entity2 . MATERIALS AND METHODS: Using a monoclonal antibody to @entity6 and a standard avidin- @entity4 complex technique, immunostaining was performed on paraffin-embedded cell blocks of 57 cases with the following cytologic diagnoses: (a) @entity2 (20 cases); (b) atypical cytology, cannot exclude @entity2 (19 cases); and (c) nonneoplastic thyroid (18 cases). The staining reaction in each case was graded on the basis of percentage of epithelial cells stained (1+, <10%; 2+, <10%-50%; 3+, >50). Tissue follow-up was available in all cases. RESULTS: Nineteen (95%) of 20 cases with an unequivocal diagnosis of @entity2 were positive for @entity6 (3+). Tissue follow-up confirmed @entity2 in all 20 cases. Of the 19 cases with a diagnosis of atypical cytology, cannot exclude @entity2 , 7 (37%) cases displayed 3+ immunostaining and subsequent excision confirmed @entity2 in all 7 cases. The remaining 12 cases with 1+ immunostaining included surgically confirmed @entity7 (6 cases), @entity1 (2 cases), @entity3 (3 cases), and @entity2 (1 case). The follicular cells in 18 cases with a cytologic diagnosis of nonneoplastic thyroid showed 1+ immunostaining. Histologic follow-up of these cases confirmed the nonneoplastic cytologic diagnoses. CONCLUSIONS: @entity6 immunostaining of cell block preparations of thyroid aspirates serves as a useful tool for the diagnosis of @entity2 . Strong immunostaining (3+) for @entity6 aids in accurate diagnosis of @entity0 in cytomorphologically equivocal cases of @entity2 .

title: XXXX immunolocalization in cell block preparation of thyroid aspirates. An adjunct to fine-needle aspiration diagnosis of @entity5 .

answer: @entity6


abstract: BACKGROUND: Two treatments, ranibizumab and @entity3 implant, for @entity2 due to @entity1 ( @entity1 ) secondary to @entity4 ( @entity4 ) have recently been studied in clinical trials. There have been no head to head comparisons of the two treatments, and improvement measured as gain in Best Corrected Visual Acuity (BCVA) was reported using different outcomes thresholds between trials. To overcome these limitations, and inform an economic model, we developed a combination of a multinomial model and an indirect Bayesian comparison model for multinomial outcomes. METHODS: Outcomes of change from baseline in BCVA for @entity3 compatible with those available for ranibizumab, reported by 4 randomised controlled trials, were estimated by fitting a multinomial distribution model to the probability of a @entity0 achieving outcomes in a range of changes from baseline in BCVA (numbers of letters) at month 1. A Bayesian indirect comparison multinomial model was then developed to compare treatments in the Branch @entity4 (BRVO) and Central @entity4 (CRVO) populations. RESULTS: The multinomial model had excellent fit to the observed results. With the Bayesian indirect comparison, the probabilities of achieving >= 20 letters, with 95% credible intervals, at month 1 in @entity0 with BRVO were 0.191 (0.130, 0.261) with ranibizumab and 0.093 (0.027, 0.213) with @entity3 . In @entity0 with CRVO, probabilities were 0.133 (0.082, 0.195) (ranibizumab) and 0.063 (0.016, 0.153) ( @entity3 ). Probabilities of a gain in >= 10 letters in BRVO @entity0 were 0.500 (0.365, 0.650) v 0.459 (0.248, 0.724) and in CRVO @entity0 0.459 (0.332, 0.602) v 0.498 (0.263, 0.791) for ranibizumab and @entity3 treatments respectively. The comparisons also favoured ranibizumab at month 6 although changes to therapies after month 3 may have introduced bias. CONCLUSION: The newly developed combination of multinomial and indirect Bayesian comparison models indicated a trend for ranibizumab association with a greater percentage of @entity1 @entity0 achieving @entity2 than @entity3 at months 1 and 6 in a common clinical context, although results were not classically significant. The method was a useful tool for comparisons of probability distributions between clinical trials that reported events on different categorical scales and estimates can be used to inform economic models.

title: Indirect comparisons of ranibizumab and @entity3 in @entity1 secondary to XXXX .

answer: @entity4


abstract: PURPOSE: To examine the distribution and timing of expression of nonmuscle myosin IIB (nmMyH IIB) and the extraocular muscle (EOM)-specific myosin (EO- @entity2 ) during postnatal development of the @entity0 extraocular muscles. METHODS: Whole orbits were collected from postnatal development day (P) 1 through P30 from @entity0 . Samples were analyzed by immunofluorescence microscopy and Western blot to examine the distribution and abundance of nmMyH IIB and EO- @entity2 compared with other myosin isoforms and sarcomeric a-actinin. Polyclonal antibodies were produced to specifically detect EO- @entity2 . Postnatal limb muscles were used as control. RESULTS: Analysis of EOM morphology in the developing orbits indicates that the global and orbital layers are not evident until day @entity1 . The distribution of nmMyH IIB changes between days P10 and @entity1 from a subsarcolemma distribution to an intrafiber distribution in the global layer. EO- @entity2 appears by day @entity1 , primarily in the orbital layer of the EOMs. Sarcomeric a-actinin was equally abundant in the EOMs at all stages. Fetal @entity2 was the predominant isoform at day P1 but slowly diminished in abundance with age in a layer-specific manner. CONCLUSIONS: These data demonstrate that significant changes occur in the EOMs from P10 to @entity1 and suggest that visual stimulation may play a role in the signals that regulate both nmMyH IIB and EO- @entity2 developmental transitions. The pronounced distinctions of the orbital and global layers occurring by @entity1 establish the adult morphologic phenotype of the muscle.

title: Postnatal changes in the developing XXXX extraocular muscles.

answer: @entity0


abstract: UNASSIGNED: We studied the reproducibility and stability of limbal stem cell deficiency (LSCD) in @entity0 following controlled @entity2 . In one method, corneal and limbal epithelia were entirely removed with a 0.5  mm metal burr. In the other, limbus to limbus epithelial removal with the burr was followed by @entity1 to the limbus. These two methods were compared with a previously published one. Unwounded corneas were used as control. The corneas were examined monthly for three months by slit lamp with @entity3 staining. Immunofluorescence staining for @entity4 and 8 on corneal wholemount and cross sections were performed to determine the phenotype of the epithelium. Mechanical shaving of the epithelium, with or without @entity1 , resulted in a reproducible state of LSCD marked by superficial neovascularization, reduce of @entity4 expression and presence of goblet cells on the @entity2 . The phenotype was stable in 100% of the eyes up to at least three months. @entity1 produced a more severe phenotype with more significant stromal opacification. These @entity2 models may be useful for studying the mechanisms leading to limbal stem cell deficiency.

title: Stability of limbal stem cell deficiency after mechanical and @entity1 in XXXX .

answer: @entity0


abstract: INTRODUCTION: This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety in @entity0 who underwent bilateral deep brain stimulation (DBS) of the fornix for the treatment of mild probable @entity2 . METHODS: The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled, feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in @entity0 with mild probable @entity2 . Intraoperative and perioperative data were collected prospectively. All @entity0 underwent postoperative magnetic resonance imaging (MRI). Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine relationship between the AE and the study procedure. RESULTS: Between June 1, 2012 and April 30, 2014, 42 @entity0 with mild probable @entity2 were treated with bilateral fornix DBS (mean age 68.2    7.8 [range 48.0-79.7], 19 male and 23 female). The mean planned target coordinates were x = 5.2    1.0 mm (range 3.0-7.9), y = 9.6    0.9 mm (range 8.0-11.6), z = -7.5    1.2 mm (range -5.4 to 10.0), and the mean postoperative stereotactic radial error on MRI was 1.5    1.0 mm (range 0.2-4.0). Mean length of hospitalization was 1.4    0.8 days. Twenty-six (61.9%) @entity0 experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 @entity0 (11.9%). Four (9.5%) @entity0 required return to surgery: 2 for explantation because of infection, 1 for lead repositioning, and 1 for @entity3 . No @entity0 experienced @entity1 as a result of the study and no mortalities were reported. CONCLUSION: Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by @entity0 with mild probable @entity2 .

title: 130   Bilateral Fornix Deep Brain Stimulation for XXXX : Surgical Safety in the ADvance Trial.

answer: @entity2


abstract: BACKGROUND: @entity2 in @entity3 has a wide spectrum that includes both high and low turnover conditions. Specific preventive and therapeutic measures require knowledge of the nature of bone involvement. Bone biopsy with static and dynamic histomorphometry is the gold standard for characterization of @entity1 . However, non-invasive biochemical tests, especially serum intact @entity5 ( @entity5 ), have a good correlation with histomorphometry. We studied the clinical and biochemical profile of @entity2 in a sample of north Indian @entity0 with @entity3 . METHODS: Twenty-nine @entity0 of @entity3 were evaluated clinically, radiologically ( @entity7 on hand X-rays) and biochemically (serum @entity4 , @entity8 , total alkaline phosphatase, intact @entity5 , osteocalcin, @entity10 , @entity9 ). Bone histomorphometry could be done in 4 patients. RESULTS: Serum intact @entity5 within or below the non-uraemic normal range, an index of @entity2 , was seen in 17 (58.6%) patients. Serum osteocalcin, a bone formation marker, was within or below the non-uraemic normal range in 65.5% patients. Serum intact @entity5 and osteocalcin had a significant positive correlation (r = 0.6). @entity0 groups with clinical or radiological evidence of @entity2 had serum intact @entity5 and osteocalcin levels comparable to those lacking such features. Serum intact @entity5 and total alkaline phosphatase were lower in haemodialysed (n = 25) @entity0 than in those who had not received haemodialysis (n = 4). Low (< 10 ng/ml) serum @entity10 levels were seen in 7 (24%) @entity0 while @entity9 was low (< 15.9 pg/ml) in 20 (69%) @entity0 . The biochemical parameters accurately reflected the bone histology (n = 4). CONCLUSIONS: Our data show that the majority of north Indian @entity0 with @entity3 have biochemical evidence of @entity2 . Empirical use of @entity4 salts and active @entity6 analogues without documentation of parathyroid status carry the risk of further @entity2 .

title: Calcitropic hormonal status in north Indian XXXX with end-stage renal disease.

answer: @entity0


abstract: BACKGROUND: @entity3 is a rare chronic disease that mainly affects young @entity0 and may influence fertility and pregnancy in these @entity0 . OBJECTIVES: To describe pregnancy and labor in a @entity0 suffering from @entity3 and to review the relevant literature. METHODS: Computerized literature research. RESULTS: The disease of 9 years' duration did not relapse during pregnancy under continuous treatment with @entity2 , cytotoxic drugs, @entity6 and @entity4 . Pregnancy was uneventful and ended with preterm vaginal delivery at 35 weeks, of a 2299 gram healthy neonate. The @entity0 did well during the postpartum period and 6 months thereafter. Since there is no single diagnostic test for the disease, the diagnosis is based on the combination of clinical, laboratory, and histopathological findings and by exclusion of other causes of @entity1 . CONCLUSIONS: There is paucity of data in the literature on pregnancy in these @entity0 but the treatment protocols seem to be effective for the mother and safe for the fetus. @entity5 rates appear to be currently lower than in the past. Given that relapse cannot be predicted, close surveillance during pregnancy is warranted.

title: [ XXXX during pregnancy].

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) and late-onset @entity2 (LOS) are the leading causes of @entity1 among preterm @entity0 in the developed world. This study aimed to explore the serum proteome and metabolome longitudinally in preterm @entity0 with @entity4 or LOS, matched to controls. METHODS: Nineteen @entity0 (10 cases, 9 controls) were included. A sample 14 d prior to and following, as well as at disease diagnosis, was included for cases. Controls had serum matched at diagnosis for corresponding case. All samples (n = 39) underwent shotgun proteomic analysis, and 37 samples also underwent metabolomics analysis using ultra performance liquid chromatography-tandem mass spectrometry. RESULTS: The proteomic and metabolomic profiles of serum were comparable between all @entity0 . Eight proteins were associated with @entity4 and four proteins were associated with LOS. @entity3 was increased in all @entity4 @entity0 at diagnosis. CONCLUSION: No single protein or metabolite was detected in all @entity4 or LOS cases which was absent from controls; however, several proteins were identified which were associated with disease status. The differing expression of these proteins between diseased @entity0 potentially relates to differing pathophysiology of disease. Thus, it is unlikely a single biomarker exists for @entity4 and/or LOS.

title: Metabolomic and proteomic analysis of serum from preterm @entity0 with necrotising XXXX .

answer: @entity2


abstract: There are an increasing number of healthcare smartphone applications ('apps') available. @entity2 presents a major healthcare burden. @entity0 are increasingly keen to educate themselves regarding the diagnosis and management of their condition. There is no formal regulation of healthcare apps, including a large number of apps relating to @entity2 . This review aims to examine the range of apps available, and the prevalence of healthcare professional input. Four international smartphone app stores were searched: Apple's App Store, Google Play (Android), BlackBerry App World and the Windows Phone App store. A total of 42 unique apps were downloaded and analysed. Recorded data included the cost (  / ), publisher information, number of ratings, average rating and any documentation of medical professional involvement. Twenty-one (50  %) apps required payment for download. The mean cost was   3.58 ( 6.04) with range   0.61-  34.90 ( 1.03- 58.87). Thirty-three (79  %) of the 42 apps were designed to be used by @entity0 . Fifteen (36  %) of the 42 apps had clear input from health professionals. Twenty-two apps offered @entity0 information, including dietary advice on lowering @entity1 intake, which is contrary to current evidence-based practice. We conclude that @entity2 apps have future potential to inform both @entity0 and healthcare professionals on stone management. However, inaccuracies in the recommendations made by some apps can be misleading or even harmful due to a lack of specialist involvement. We recommend improving the usefulness of these apps by seeking a 'quality stamp' from recognised urological organisations and greater clinician involvement in future app development.

title: Smartphone apps for XXXX .

answer: @entity2


abstract: UNASSIGNED: Calmodulins (CaMs) regulate numerous @entity0 -mediated cellular processes in plants by interacting with their respective downstream effectors. Due to the limited number of CaMs, other @entity1 sensors modulate the regulation of @entity0 -mediated cellular processes that are not managed by CaMs. Of 50 CaM-like (CML) proteins identified in @entity3 , we characterized the function of CML10. Yeast two-hybrid screening revealed phosphomannomutase (PMM) as a putative interaction partner of CML10. In vitro and in  vivo interaction assays were performed to analyze the interaction mechanisms of CML10 and PMM. PMM activity and the phenotypes of cml10 knock-down mutants were studied to elucidate the role(s) of the CML10-PMM interaction. PMM interacted specifically with CML10 in the presence of @entity0 through its multiple interaction motifs. This interaction promoted the activity of PMM. The phenotypes of cml10 knock-down mutants were more sensitive to stress conditions than wild-type plants, corresponding with the fact that PMM is an enzyme which modulates the biosynthesis of @entity2 , an antioxidant. The results of this research demonstrate that a @entity1 sensor, CML10, which is an evolutionary variant of CaM, modulates the stress responses in @entity3 by regulating @entity2 production.

title: CML10, a variant of calmodulin, modulates XXXX synthesis.

answer: @entity2


abstract: BACKGROUND: We wanted to study the incidence, distribution and characteristics of paediatric out-of-hospital emergency care on a population level. This knowledge could ameliorate the design and education of emergency medical services and their personnel. METHODS: We studied all (n = 1863) emergency medical services responses and the @entity0 records for paediatric @entity0 (age 0-16 years) in Helsinki, Finland (population 603,968, paediatric population 92,742) during a 12-month period (2012). @entity0 characteristics, diagnoses, time intervals, medical treatments, procedures, vital measurements and outcome of out-of-hospital treatment were available for analysis. RESULTS: The incidence of emergency medical services -treated paediatric out-of-hospital @entity2 was 3.8/1000 inhabitants and 20/1000 1-16-year-old inhabitants. This formed 4.5% of all emergency calls, while @entity0 have a threefold share of the population (15%). Falls, dyspnoea, @entity3 and @entity5 account for half of all @entity2 . Few @entity0 suffered from a life-threatening condition or @entity1 . @entity4 or need for advanced life support measures (e.g. intubation) was rare. After evaluation by the emergency medical services, only half of the @entity0 (56%) needed ambulance transportation to hospital. Only 30 (3.7%) of the non-transported @entity0 made an unpremeditated visit to the emergency department after the original contact with the emergency medical services. All of them were well upon arrival to the emergency department. CONCLUSION: Paediatric out-of-hospital @entity2 are infrequent and have specific characteristics differing from the adult population. The design and training of emergency medical services and their personnel should focus on evaluation and management of the most frequent situations.

title: Out-of-hospital paediatric XXXX : a prospective, population-based study.

answer: @entity2


abstract: OBJECTIVES: To investigate the value of microscopic findings in the classification of @entity1 by determining whether classification of disease changes significantly with inclusion of histologic findings. METHODS: 60 @entity0 were randomly selected from a cohort of @entity0 followed at the Pediatric Inflammatory Bowel Disease Clinic at the University of California San Francisco (UCSF) Benioff @entity0 's Hospital San Francisco (BCHSF). Two physicians independently reviewed the electronic health records of the included cases to determine the Paris Classification for each @entity0 by adhering to current guidelines and then by including microscopic findings. RESULTS: Macroscopic and combined disease location classification were discordant in 34 (56.6%), with no statistically significant differences between groups. Interobserver agreement was higher in the combined classification (kappa 0.7303, 95% Confidence Interval (C.I.) 0.650-0.821) as opposed to when classification was limited to macroscopic findings (kappa 0.5318, 95% C.I. 0.403-0.581). When evaluating the proximal upper gastrointestinal tract (Paris L4a) the interobserver agreement was better in macroscopic compared with the combined classification. CONCLUSION: Disease extent classifications differed significantly when comparing isolated macroscopic findings (Paris Classification) with the combined scheme that included microscopy. Further studies are needed to determine which scheme provides more accurate representation of disease extent.

title: Addition of Histology to the Paris Classification of XXXX Alters Classification of Disease Location.

answer: @entity1


abstract: @entity1 in @entity3 ( @entity3 ) @entity0 is common. @entity8 is a potential side effect of @entity4 ( @entity4 ) and a frequent limiting-dose effect of @entity9 ( @entity10 ). The aim of the study was to investigate the impact of @entity4 on @entity5 in @entity3 @entity0 treated with radiotherapy and @entity10 . A cohort of 101 newly diagnosed @entity3 @entity0 treated with radiotherapy and @entity10 was reviewed. Clinical data, presence of @entity2 , @entity4 use, platelet count, and accumulated @entity10 dose were analyzed at each cycle. @entity5 was operationalized as a continuous platelet count and a dichotomic variable (cut-off <100.000/mm(3)). This cut-off represents the threshold beyond which @entity10 treatment is modified. A linear and a probit pooled cross-sectional regression analysis were used to study the impact of age, gender, @entity4 , and accumulated @entity10 on @entity5 . Impact of @entity4 on survival was also analyzed. Thirty-five @entity0 (35%) presented @entity2 at onset and 18 (27%) during follow-up. Seven (13%) needed two or more @entity4 for @entity2 control. Grade 3-4 @entity5 was found in 8%. @entity7 was related to accumulated @entity10 (p  <  0.001), age (p  <  0.001), and @entity6 (p  =  0.004). Platelet count <100.000/mm(3) was only associated with accumulated @entity10 (p  =  0.001). Recursive Partitioning Analysis prognostic class was the only variable with significant impact on survival. @entity6 and age had an independent negative effect on total platelet count, although neither had an effect on critical @entity5 (<100.000/mm(3)). Therefore, the systematic withhold of valproate in @entity3 @entity0 might not be justified. Nevertheless, this negative effect may be taken into account especially in elderly @entity0 .

title: Impact of @entity4 on XXXX in @entity3 @entity0 treated with standard chemoradiotherapy.

answer: @entity5


abstract: @entity0 undergoing total hip replacement are at high risk of developing @entity3 . The 6th ACCP Consensus Conference on Antithrombotic Therapy identified two effective prophylactic methods; low molecular weight heparins (LMWH) and oral anticoagulants. However, two key issues remain controversial. The relative efficacy and safety of prophylaxis initiated pre operatively and post operatively and the optimum duration of prophylaxis. Clinical practice has diverged in North America and Europe as to the appropriate time to administer prophylaxis. This treatment is given pre-operatively in Europe and post-operatively in North America. A number of recent studies have demonstrated that an effective antithrombotic agent administered either immediately before or after surgery may be more effective than current practice. The use of LMWH for extended thromboprophylaxis is supported by convincing data. Clinical trials have demonstrated a significant benefit of @entity4 in the prevention of @entity3 in major orthopaedic surgery. A direct @entity1 inhibitor given sc. followed by oral administration was found to be as effective and safe as LMWH for the prophylaxis of @entity2 ( @entity2 ) following major hip or knee surgery.

title: Critical appraisal of current antithrombotic trials in XXXX undergoing total hip replacement.

answer: @entity0


abstract: OBJECTIVE: To examine our experience with managing sporadic bilateral renal masses, focusing on trends in surgical management over time, because as loss of renal function is associated with adverse cardiovascular outcomes, nephron-sparing approaches are increasingly emphasized in the treatment of @entity2 , creating new challenges for the treatment of @entity1 . @entity0 AND METHODS: We identified all @entity0 who underwent partial or radical nephrectomy ( @entity3 or RN) at Memorial Sloan-Kettering Cancer Center (MSKCC) during 1989-2008. We compared @entity0 presenting with synchronous bilateral renal masses with those with @entity1 and evaluated trends in management using logistic regression. RESULTS: Of the 2777 @entity0 studied, 73 (3%) presented with synchronous bilateral disease. The overall survival and clinical/pathological features between groups were similar. Of those @entity0 receiving bilateral operations for @entity1 , three had bilateral RN (all before 2003), 28 (38%) had an RN followed by a @entity3 , 10 (14%) had a @entity3 then an RN, and 32 (44%) had bilateral @entity3 . Over time, the proportion of @entity0 receiving bilateral @entity3 increased (P < 0.001); 13 of 14 @entity0 after 2005 had bilateral @entity3 , compared with only 34% (16 of 45) between 1995 and 2004. Forty-five @entity0 (62%) had the larger @entity1 removed during the first operation. The concordance rate between @entity1 in a specific histological subtype was 70% (51/73), and concordance for benign vs malignant disease was 90% (66/73). CONCLUSION: The use of @entity3 in the management of synchronous bilateral renal masses has increased over time. The contemporary treatment of synchronous bilateral renal masses at MSKCC involves staged @entity3 when feasible, with the more involved kidney (often larger @entity1 ) operated on first.

title: Developments in the surgical management of XXXX .

answer: @entity2