abstract: BACKGROUND: @entity2 is a major contributing factor in adult @entity1 and may adversely affect decision-making in other safety areas such as use of seatbelts and motorcycle helmets. The magnitude of risk-taking behavior and poor decision-making among adolescent @entity1 @entity0 is not fully appreciated. Our objective was to determine the prevalence and pattern of risk-taking behavior among adolescents (age < or = 20 years) admitted to an adult Level I @entity1 center. METHODS: The @entity1 registry was used to identify @entity0 . Data collected included age, mechanism of injury, blood @entity2 and urine toxicology results, seatbelt and helmet use, Glasgow @entity3 Score, Injury Severity Score, and outcome. RESULTS: Fifteen percent of all admissions to an adult @entity1 center were adolescents (648 of 4,291). Twenty-one percent of adolescents (138 of 648) and 30% of adults (1,067 of 3,643) tested positive for blood @entity2 on admission. Seatbelts were worn by only 19% of adolescent motor vehicle crash admissions versus 30% of adults. Only 7% of adolescents (6 of 83) with detectable @entity2 used restraints, compared with 22% (67 of 310) without documented @entity2 ingestion (p < 0.05). Adults were somewhat better at restraint use (16% of @entity2 -positive @entity0 and 36% without @entity2 ). Eight of 23 minors (35%) in motorcycle/bicycle crashes were wearing a helmet, compared with 95 of 168 adults (57%). Overall, 6.7% of adolescents and 8.6% of adults had positive toxicology screens. Adolescents with known @entity2 consumption were twice as likely to have a positive toxicology screen for illegal drugs (15 vs. 7%; p < 0.05). @entity2 was also frequently detected among adolescents with mechanisms of injury other than motor vehicle and motorcycle crashes, such as violence (25%) and falls (44%). CONCLUSION: @entity2 is frequently involved in all types of @entity1 , for adolescents as well as adults. This is often compounded by poor decision-making and multiple risk-taking behaviors.

title: Risk-taking behaviors among adolescent XXXX @entity0 .

answer: @entity1


abstract: PURPOSE: Antibiotics suppress normal gut flora, allowing overgrowth of acquired or native @entity6 , with release of toxins that cause @entity1 . Oral @entity3 is used to treat antibiotic-associated @entity5 ( @entity9 ). This study was designed to determine whether oral @entity3 , as part of preoperative bowel preparation, prevents or decreases incidence of antibiotic-associated @entity5 after elective colonic and rectal procedures. METHODS: Eighty-two @entity0 (40 @entity0 ) were prospectively, randomly assigned to receive one of two oral antibiotic regimens before colorectal surgery. All @entity0 underwent mechanical bowel preparation with @entity4 -electrolyte lavage solution before administration of oral antibiotics. Group 1 (n = 42) @entity0 received three doses (1 g/dose) of @entity8 and @entity7 . Group 2 (n = 40) @entity0 received three doses (1 g/dose) of @entity8 and @entity3 . Both groups received one preoperative and three postoperative doses of intravenous @entity10 (2 g/dose). Both groups had stool samples tested for @entity6 toxin in the preoperative and postoperative periods by enzyme-linked immunoabsorbent assay or by tissue culture @entity2 . @entity0 with preoperative stool studies positive for @entity6 were excluded from the study. RESULTS: Treatment groups were not different for age, gender, or surgical procedure. Mean age +/- 1 standard deviation was 67.6 +/- 13.6 (range, 34-94) years in Group 1 and 62.1 +/- 13.5 (range, 35-84) years in Group 2 (P = 0.069). Mean length of hospital stay +/- 1 standard deviation was 9.76 +/- 4.9 (range, 4-28) days for Group 1 and 8.05 +/- 2.6 (range, 3-14) days for Group 2 (P = 0.053). Five @entity0 in Group 1 ( @entity8 and @entity7 ) and one @entity0 in Group 2 ( @entity8 and @entity3 ) had positive stool studies for @entity6 . Relative risk of colonization with @entity6 in Group 1 was 4.76 times that in Group 2 (95 percent confidence interval, 0.581, 39). This difference was not statistically significant (P = 0.202). There were no significant differences in @entity6 colonization rates with respect to age, length of stay, or gender. CONCLUSIONS: This study suggests that there may be a clinical association between use of @entity3 preoperatively and inhibition of intestinal colonization by @entity6 in this @entity0 population undergoing colonic and rectal surgery.

title: @entity3 may inhibit intestinal colonization with XXXX .

answer: @entity6


abstract: Carcinogenesis studies of crocidolite @entity4 were conducted with male and female F344/ @entity0 . This form of @entity4 was administered at a concentration of 1% in pelleted diet for the lifetime of the @entity0 , starting with the dams of the study animals. The studies were started in January 1978 and ended in December 1980. Group sizes were 118 for male and female controls and 250 for male and female crocidolite @entity4 -exposed @entity0 . The offspring from mothers exposed to crocidolite @entity4 and the controls were similar in size at birth but were slightly smaller at weaning and remained so throughout their life. Feed consumption and survival were comparable in the exposed and control groups. No overt @entity1 was observed in the crocidolite @entity4 -exposed animals. There was an elevated (P<0.05) incidence of thyroid gland C-cell @entity3 (control, 4/117, 3%, vs. exposed, 23/250, 9%) and of @entity2 (12/117, 10%, vs. 46/250, 18%) in crocidolite @entity4 -exposed female @entity0 relative to concurrent controls. Because these control incidences were low relative to control incidences observed in other contemporary studies at this laboratory (21% for @entity2 ), this slight increase was not regarded as being biologically important. The data, documents, and pathology materials from the lifetime studies of @entity5 @entity4 have been audited. The audit findings show that the conduct of these studies is documented adequately and support the data and results presented in this Technical Report. Conclusions: Under the conditions of these feed studies, crocidolite @entity4 was not overtly toxic and did not cause a carcinogenic response when ingested at a concentration of 1% in the diet by male and female F344/ @entity0 for their lifetime. Levels of Evidence of Carcinogenicity: Male @entity0 : Negative Female @entity0 : Negative

title: NTP Toxicology and Carcinogenesis Studies of @entity5 (CAS No. 12001-28-4) In F344/ XXXX (Feed Studies).

answer: @entity0


abstract: BACKGROUND: To determine @entity6 levels in @entity0 with suspected intracranial events and to determine whether @entity6 levels could be used in the discrimination of @entity2 , @entity4 , and @entity3 in the emergency room. METHODS: Blood samples were obtained from the @entity0 prior to imaging to determine the levels of @entity6 . @entity0 were divided into diagnostic groups after the imaging. One hundred and seventy-six @entity0 , who were enrolled in the study, were as follows: 50 @entity2 ( @entity2 ) @entity0 (M/F: 24/26), 47 @entity4 ( @entity4 ) @entity0 (M/F: 27/20), 29 @entity3 ( @entity3 ) @entity0 (M/F: 17/12) and 50 healthy controls. Differences and correlations between groups were analyzed. RESULTS: Plasma levels of @entity6 in @entity0 with @entity2 , @entity4 , and @entity3 were 5.49 ng/dL (IQR 4.73 to 6.96), 4.50 ng/dL (IQR 3.04 to 9.77), and 5.90 ng/dL (IQR 3.11 to 13.26), respectively. It was found to be 2.0 ng/dL (IQR 1.57 to 2.5) in healthy volunteers. There was no significant correlation between @entity6 levels and @entity5 Score (ICHS) (r = 0.231, p = 0.118). However, significant positive correlation was found between @entity6 levels with the National Institutes of Health @entity1 Scale (NIHSS) (r = 0.365, p = 0.009) and the BotterelHunt and Hess Scale (BHHS) (r = 0.590, p = 0.001). The @entity6 levels of 41 (32.5%) @entity0 who died were found to be significantly higher than those 85 (67.5%) @entity0 who were discharged (p < 0.001). CONCLUSIONS: @entity6 levels in @entity0 with @entity2 , @entity4 , and @entity3 are significantly higher than healthy volunteers, but the plasma level of @entity6 is not decisive in the discrimination of @entity2 , @entity4 , and @entity3 .

title: XXXX Levels in @entity2 , @entity4 and @entity3 .

answer: @entity6


abstract: The action of @entity5 ( @entity5 ) on @entity0 signalling in HeLa cells and cardiac myocytes was investigated. Consistent with other studies, we found that superfusion of cells with @entity5 rapidly inhibited @entity2 (InsP(3))-mediated @entity0 release and store-operated @entity0 entry (SOC). In addition to abrogating hormone-evoked @entity0 responses, @entity5 could antagonise @entity0 signals evoked by a membrane permeant InsP(3) @entity4 . @entity5 also slowed the recovery of intracellular @entity0 signals consistent with an effect on @entity0 ATPases. The inhibitory action of @entity5 on InsP(3) receptors (InsP(3)Rs), SOC channels and @entity0 pumps persisted for several minutes after washout of the compound. Application of @entity5 to unstimulated cells had no effect on subsequent @entity0 responses suggesting that it has a use-dependent action. Mitochondria in cells treated with @entity5 showed a rapid and slowly reversible swelling. @entity5 did not cause the mitochondria to depolarise, but it reduced the extent of mitochondrial @entity1 uptake. Although @entity5 has been demonstrated not to affect voltage-operated @entity0 channels or @entity3 receptors, we found that it gave a concentration-dependent long-lasting inhibition of @entity0 signalling in electrically-stimulated cardiac myocytes, where InsP(3)Rs and SOC channels do not play a significant role. Our data suggest that @entity5 has multiple cellular targets, a use-dependent action, is difficult to reverse and may affect @entity0 signalling in cell types where InsP(3) and SOC are not active.

title: XXXX ( @entity5 ) antagonises @entity2 -induced @entity1 release, inhibits @entity1 pumps and has a use-dependent and slowly reversible action on store-operated @entity1 entry channels.

answer: @entity5


abstract: OBJECTIVES: We determined whether crowding at emergency shelters is associated with a higher incidence of @entity1 among disaster evacuees and identified the minimum required personal space at shelters. DESIGN: Retrospective review of medical charts. SETTING: 30 shelter-based medical clinics in Ishinomaki, Japan, during the 46 days following the Great Eastern Japan Earthquake and Tsunami in 2011. @entity0 : Shelter residents who visited eligible clinics. OUTCOME MEASURES: Based on the result of a locally weighted scatter-plot smoothing technique assessing the relationship between the mean space per evacuee and cumulative incidence of @entity1 at the shelter, eligible shelters were classified into crowded and non-crowded shelters. The cumulative incidence per 1000 evacuees was compared between groups, using a Mann-Whitney U test. To assess the association between shelter crowding and the daily incidence of @entity1 per 1000 evacuees, quasi-least squares method adjusting for potential confounders was used. RESULTS: The 30 shelters were categorised as crowded (mean space per evacuee <5.0 m(2), 9 shelters) or non-crowded (>=  5.0 m(2), 21 shelters). The study included 9031 @entity0 . Among the eligible @entity0 , 1079 @entity0 (11.9%) were diagnosed with @entity1 . Mean space per evacuee during the study period was 3.3 m(2) (SD, 0.8 m(2)) at crowded shelters and 8.6 m(2) (SD, 4.3 m(2)) at non-crowded shelters. The median cumulative incidence of @entity1 did not differ between the crowded shelters (2.3/1000 @entity0 -days (IQR, 1.6-5.4)) and non-crowded shelters (1.9/1000 @entity0 -days (IQR, 1.0-2.8); p=0.20). In contrast, after adjusting for potential confounders, crowded shelters had an increased daily incidence of @entity1 (2.6 per 1000 @entity0 -days; 95% CI 0.2 to 5.0/1000 @entity0 -days, p=0.03) compared to that at non-crowded shelters. CONCLUSIONS: Crowding at shelters may exacerbate @entity1 in disaster evacuees; therefore, appropriate evacuation space requirements should be considered.

title: Association between shelter crowding and incidence of XXXX among disaster evacuees: a retrospective medical chart review study.

answer: @entity1


abstract: 1. Metallothioneins (MTs) are small metal-binding proteins. The genes that encode MT isoforms I and II are also induced by metal at transcription level. Commonly expressed in the central nervous system (CNS) their putative function is protection against reactive @entity1 species (ROS), however their role may not be restricted to this sole purpose. The physiological function of MTs in the peripheral nervous system (PNS) requires further investigation. 2. Examination of phrenic nerve cross-sections from @entity4 and @entity3 double knockout @entity0 ( @entity4 , II KO) showed a significant reduction (P=0.0032) in the mean myelinated axons calibre compared to 129/Sv wild type (Wt) counterparts. 3. Analysis of the Gaussian spectra specifically attributes this atrophy to the large myelinated class (>or=4 microm) of axon considered selectively vulnerable in @entity2 ( @entity2 ). Supporting the results, these axons also showed increased irregularity in shape. 4. In conclusion, MTs directly or indirectly influence the radial equilibrium of large myelinated motor axons.

title: Atrophy of large myelinated axons in XXXX , II knockout @entity0 .

answer: @entity4


abstract: BACKGROUND: Earlier approaches to pallidotomy for @entity2 had significant complication rates. More recent approaches show fewer complications, but the effect of pallidotomy on cognition is unclear. The current study was conducted to examine the neuropsychological effects of unilateral pallidotomy. METHODS: Neuropsychological testing was performed on @entity0 with medically refractory, predominantly unilateral @entity2 at baseline and after unilateral ventral pallidotomy (n=28) or after an equivalent period without surgery in control @entity0 (n=10). RESULTS: Pallidotomy @entity0 showed no significant changes from baseline to retesting relative to the control group for any measure. Across all of the tests administered, only five of the surgery @entity0 showed a significant decline, and of these five none declined on more than one test. @entity3 did not relate to @entity1 . The pallidotomy group showed a significant improvement in motor functioning and activities of daily living whereas the control group did not. These measures were not associated with the neuropsychological test scores at baseline or retest. CONCLUSIONS: Stereotactic unilateral ventral pallidotomy does not seem to produce dramatic @entity1 in most @entity0 .

title: Cognitive functioning after pallidotomy for XXXX .

answer: @entity2


abstract: UNASSIGNED: The present study explores anti-MRSA ( @entity1 resistant @entity0 ) activity of a bioactive phytochemical constituent, @entity2 obtained from the medicinal herb, Nigella sativa Linn. Based on the initial assessment on crude extract of seeds of Nigella sativa Linn, the pure active constituent was employed in the study. Total of 99 @entity0 strains which comprised of 40 type and 59 clinical strains were selected for the study. Minimum inhibitory concentration (MIC), bactericidal activity, post-antibiotic effect (PAE) and propensity to select resistant mutants were determined using standard protocols. Results revealed that @entity2 exhibited MIC in the range of 8 - 16  g ml(-1) and MIC90 of 16  g ml(-1) against @entity0 strains. It was bactericidal to @entity0 by demonstrating >3 log kill. It showed a longer post-antibiotic effect (PAE) of 3.2  0.2 h. Upon exposure to high density inoculum of @entity0 , it did not select resistant mutants. Transmission electron microscopy of @entity2 treated @entity0 showed no lysis but damage to cell wall and cell membrane which corroborated well with the salt tolerance and bacteriolysis assays. In conclusion, MIC90 , bactericidal property, longer PAE, absence of resistant mutant selection and damages in cell membrane and cell wall imply a promising anti-MRSA activity of @entity2 . This article is protected by copyright. All rights reserved.

title: In vitro profiling of anti-MRSA activity of XXXX against selected type and clinical strains.

answer: @entity2


abstract: BACKGROUND: Little is known about endothelial activation under the influence of endovascular temperature management. This analysis was designed to measure the endothelial markers @entity3 ( @entity4 ( @entity1 ) in endovascularly based prophylactic normothermia versus conventional temperature management. METHODS: In this randomized controlled trial @entity0 with spontaneous subarachnoid or spontaneous @entity2 were prospectively enrolled and randomized in two treatment arms: (a) prophylactic normothermia group with target core temperature 36.5  C using endovascular cooling, (b) active control group with conventional stepwise predefined fever management using antipyretic medication and surface cooling. Blood samples were obtained on days 1, 4, and 7. In a substudy @entity4 were measured in 63 @entity0 for whom samples on consecutive days were available. RESULTS: The median total fever burden during the course of treatment was 0.0  C and 5.9  C  h in the endovascular and the conventional group, respectively (P  <  0.0001). Angiopoietin serum levels did not yield a statistical difference when comparing the two treatment arms. @entity3 was significantly lowered, whereas @entity1 levels were significantly elevated on day 4 compared to baseline levels irrespective of group allocation (P  <  0.0001). The application of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with significantly increased @entity3 (P  <  0.05) and lower @entity1 levels on day 7 (P  <  0.05). CONCLUSIONS: Endovascular long-term temperature management did not alter @entity4 levels compared to the control group indicating that the endovascular cooling technique itself does not lead to additional endothelial impairment. However, application of NSAIDs led to lower @entity1 serum concentrations in the endovascular group.

title: Endovascular cooling and endothelial activation in hemorrhagic stroke XXXX .

answer: @entity0


abstract: In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of @entity2 in American @entity0 . We examined four categories of illness: @entity6 , @entity4 , @entity1 , and @entity5 . To estimate the proportion of each attributable to toxins in the environment, we used an environmentally attributable fraction (EAF) model. EAFs for @entity6 , @entity4 , and @entity1 were developed by panels of experts through a Delphi process, whereas that for @entity5 was based on data from the National Academy of Sciences. We define environmental pollutants as toxic chemicals of @entity0 origin in air, food, water, and communities. To develop estimates of costs, we relied on data from the U.S. Environmental Protection Agency, Centers for Disease Control and Prevention, National Center for Health Statistics, the Bureau of Labor Statistics, the Health Care Financing Agency, and the Practice Management Information Corporation. EAFs were judged to be 100% for @entity6 , 30% for @entity4 (range, 10-35%), 5% for @entity1 (range, 2-10%), and 10% for @entity5 (range, 5-20%). Total annual costs are estimated to be  54.9 billion (range  48.8-64.8 billion):  43.4 billion for @entity6 ,  2.0 billion for @entity4 ,  0.3 billion for childhood @entity1 , and  9.2 billion for @entity5 . This sum amounts to 2.8 percent of total U.S. health care costs. This estimate is likely low because it considers only four categories of illness, incorporates conservative assumptions, ignores costs of @entity3 and suffering, and does not include late complications for which etiologic associations are poorly quantified. The costs of pediatric environmental disease are high, in contrast with the limited resources directed to research, tracking, and prevention.

title: Environmental pollutants and disease in American @entity0 : estimates of morbidity, mortality, and costs for @entity6 , XXXX , @entity1 , and developmental disabilities.

answer: @entity4


abstract: OBJECTIVE: Investigate the expression and significance of @entity2 in @entity4 . METHODS: Retrospective analysis of clinical data for 151 @entity4 @entity0 (BR group), complete blood count and blood bacterial culture etc.; in addition, 150 general @entity3 @entity0 (BI group) and 135 @entity0 in healthy physical condition upon testing (NC group) are selected respectively as the control groups to comparatively study expression of white blood cells and @entity2 for @entity4 @entity0 . Adopt t test to compare measurement data. RESULTS: In comparison with BI group, WBC, NE, EO, MO, NE% and EO% in BR group are reduced but LY, LY% and MO% are increased and such difference shows statistical significance (P<0.01). In comparison with NC group, difference of WBC and NE in BR group shows no statistical significance (P>0.05). NE%, EO and EO% are reduced but MO, LY% and MO% are increased and such difference shows statistical significance (P<0.01). LY is increased and the difference shows statistical significance (P<0.05). White blood cell count is normal or is reduced among most of @entity4 @entity0 , accounting for 90.73% (137/151); the @entity0 whose @entity2 are reduced account for 75.50% (114/151) and those whose @entity2 disappear are about 18.54% (28/151). CONCLUSION: There is an incidence rate of @entity2 decrease or disappearance in @entity4 and it shows the indication significance in the diagnosis of @entity1 .

title: Expression of XXXX be beneficial to early clinical diagnosis of @entity4 .

answer: @entity2


abstract: STUDY DESIGN: Cross-sectional study of @entity2 ( @entity2 ) in the South of France. OBJECTIVE: To determine what @entity2 think about francophone Internet sites dedicated to @entity1 ( @entity1 ). SUMMARY OF BACKGROUND DATA: @entity0 with @entity1 often seek medical information about their symptoms on the Internet. The quality of the information is usually poor. To date, the opinion of @entity2 concerning the quality of @entity1 @entity3 sites remains unknown. METHODS: We invited the 112 @entity2 in the Southern region to participate. The @entity0 used an assessment scale to evaluate 7 @entity3 sites about @entity1 in semicontrolled conditions. The quality and the importance of the different types of information (medical, nonmedical) and the design were measured on a visual analog scale (0-100) and with the point-sharing method (scale of 0-10). RESULTS: In total, 47 @entity2 responded. The median quality score for the 7 @entity3 sites was 50 (range 30-79). The score for medical information was 52.5 (10-80), for nonmedical information it was 60.4 (20-90), and for design it was 56.4 (30-85). For nonmedical information, the median relative weight was 4, and for both medical information and design it was 3. CONCLUSION: French @entity2 believe that @entity1 @entity3 sites should focus on nonmedical, practical advice; they consider the design at least as important as the medical information. This viewpoint seems to conflict in part with @entity0 ' expectations. Good-quality and interactive @entity3 sites could reduce this discordance. A list of approved sites should be available for general practitioners to recommend to their @entity0 , to supplement information given during the consultation.

title: How do general practitioners assess XXXX @entity3 sites?

answer: @entity1


abstract: A small subgroup of @entity0 , whose parents have suffered a @entity5 in their late thirties and early forties, may be at particularly high @entity2 . University Hospital "Split" gives tertiary health care to some 700,000 @entity0 in southern Croatia and treats about 300 acute @entity6 per year, with a 3-5% share in the age under 45 years. This cross-sectional, clinical and laboratory study included all the @entity0 below the age limit of 45 years, treated for acute @entity6 between 1990 and 1995, complexively 55 of them, and their natural @entity0 , 97 all in all. The results were compared to those of a stratified @entity0 's sample taken from the population of the same region. The relative weight, blood pressure, and plasma @entity4 were significantly higher in these @entity0 than in the control group (p < 0.05). In 50 of these offspring (51.5%), in addition to the obviously positive family history, detected were further @entity2 factors, defined as values above the 95th distribution percentile for age and gender. The average blood pressure, relative weight and @entity4 levels were even higher in these, "risky" @entity0 than in the studied sample (p < 0.05), and much more elevated than in the matching control pupils (p < 0.001). The most often detected risk factors were elevated @entity4 (in 44%), arterial @entity3 (in 40%), @entity1 (in 32%), and smoking (in 24%). Most of the @entity0 (64%) had only one additional risk factor, while in the remaining 36% the most prevalent risk factors were overweight (in 14 out of 18) and arterial @entity3 (in 11 out of 18). It is concluded that @entity2 factor screening among @entity0 with a positive family history of premature @entity7 is appropriate and cost-effective.

title: Premature parental XXXX is heralding elevated risk in their offspring.

answer: @entity5


abstract: Long-lasting and persistent @entity5 is a frequent consequence of spinal cord and @entity7 . Several studies point to a significantly high proportion of @entity0 who experience @entity5 following the @entity3 . This chapter gives a brief overview of the prevalence, types of persistent @entity5 , animal models that study @entity5 outcomes, and the pertinent mechanisms that underlie the development of @entity1 following traumatic spinal cord and @entity7 . @entity4 ( @entity4 ) and @entity8 ( @entity8 ) impose a high personal, social, and economic burden of disability. Although not as common as @entity9 , @entity4 and @entity8 combined might have an equivalent economic impact mainly because of the young age of @entity0 , the severity of the associated disability, and the major limitations on daily activity (Ma et al., 2014). Research-based estimates of the prevalence of persistent @entity5 are variable and high in @entity0 with @entity8 and @entity4 . Most studies indicate that about two-thirds of @entity0 with either @entity8 or @entity4 will experience @entity5 after the injury (Nampiaparampil, 2008; Siddall et al., 2003; St  rmer et al., 1997; Uomoto and Esselman, 1993). @entity5 is consistently rated as one of the most difficult problems associated with these types of @entity3 (Nepomuceno et al., 1979; Rintala et al., 1998; Stensman, 1994; Westgren and Levi, 1998), hinders the ability to participate in rehabilitation programs (Widerstr  m-Noga et al., 1999), and is difficult to treat. @entity6 delays the acquisition of an optimal level of activity (Nicholson Perry et al., 2009) and independence and adversely affects the @entity0    mood (Kennedy et al., 1997; Stroud et al., 2006). This chapter reviews and summarizes both clinical and experimental studies that focus on @entity6 after @entity4 and @entity8 . The emphasis will be in particular on the prevalence of @entity6 in @entity0 with @entity4 and @entity8 . We highlight the specific types of @entity5 that occur after injury. A survey of the different @entity2 and @entity8 evaluating @entity5 as an outcome will be discussed. Finally, we will address the mechanisms responsible for the development of @entity6 following @entity8 and @entity4 .

title: @entity6 in Neurotrauma: Implications on Spinal Cord and Traumatic XXXX

answer: @entity7


abstract: BACKGROUND/AIMS: @entity4 is considered to have the worst @entity2 . The clinicopathological features of uncinate process @entity4 are poorly published. METHODOLOGY: We retrospectively studied @entity0 who underwent pancreaticodudenectomy (PD) for @entity4 . This study included three groups of @entity0 . Group A @entity0 with pure @entity4 (PPHC), group B @entity0 with combined head and uncinate process @entity2 (CPHUC) and group C @entity0 with pure uncinate process @entity2 (PUPC). Preoperative, intraoperative and postoperative variables were collected. RESULTS: The study included 157 @entity0 . @entity5 was the most common presenting symptoms in PPHC and CPHUC. @entity3 was the most common presenting symptoms in PUPC. The mean common bile duct (CBD) and pancreatic duct diameters were significantly smallest in PUPC group (P=0.0001). The venous invasion was significantly observed more in PUPC group and vascular resection was done in 50% of cases. The number of @entity0 with microscopically @entity1 was significantly highest in PUPC group after PD than in other two groups (P=0.001). Recurrence rate occurred in 54.2% in PUPC group, 34.8% in CPHUC group and 22.7% in PPUC group after PD (P=0.007). The median survival was 19 months in PPHC groups, 16 months in CPHUC group, 14 months in PUPC group (P= 0.02). CONCLUSIONS: PUPC presented with @entity3 with more vascular infiltration. The recurrence rate was common after PD for uncinate process @entity2 especially locoregional recurrence and the overall survival rate was found to be lower for PUPC.

title: Comparative study between uncinate process @entity2 and XXXX after pancreaticodudenectomy (clincopathological features and surgical outcomes).

answer: @entity4


abstract: BACKGROUND: To determine the prognosis of @entity2 of the mandibular condyle after closed treatment. METHODS: @entity0 (n = 144) with a @entity2 of the mandibular condyle, all treated closed, were included in the study. Fracture types and position of the @entity2 parts were determined on radiographs. Follow-up was after 12 months in which the average @entity1 , experienced during the last week (visual analog scale, 100 mm), and mandibular functioning were assessed (mandibular function impairment questionnaire (MFIQ)). RESULTS: Data of 116 (81%) @entity0 , 41 @entity0 (35%) and 75 @entity0 (65%), were available for analysis. @entity2 were most common (52%). @entity2 were present in 28% of the @entity0 . @entity1 (visual analog scale score >0) was found in 9% of the @entity0 . Impaired mandibular function was found in 40% (MFIQ >0) and 24% (MFIQ > or =4) of the @entity0 . The most important risk factor for @entity1 was being a @entity0 . The most important risk factors for function impairment were > or =25 years of age and gross displacement of the @entity2 parts. CONCLUSION: The overall prognosis of mandibular function and @entity1 after closed treatment of @entity2 is good. The most important risk factor for @entity1 persisting for 1 year after closed treatment of a condylar @entity2 is being a @entity0 . The most important risk factors for function impairment are an age of > or =25 years and gross displacement of the @entity2 parts.

title: Function impairment and XXXX after closed treatment of @entity2 of the mandibular condyle.

answer: @entity1


abstract: OBJECTIVE: To determine the prevalence of @entity2 and @entity1 among @entity0 health service workers. @entity0 AND METHODS: A cross-sectional study was conducted during the 2002-2003 period. We included 487 workers of the Instituto Mexicano del Seguro Social in Colima, Mexico. We carried out a clinical measurement of weight and height. The indicator of @entity2 and @entity1 was obtained from the body mass index, that is, a @entity0 's weight in kilograms divided by height in meters squared. The used criteria were similar to the ones established by the WHO: well-nourished (BMI from 18.5 to 24.9), @entity2 (BMI from 25.0 to 29.9), and @entity1 (BMI = 30). The obtained data were captured in a computer terminal and processed by means of an automated model. We calculated the frequencies distribution and the prevalence. RESULTS: Of the 487 @entity0 , 121 (25%) had an appropriate weight, 210 (43%) showed @entity2 , and 156 (32%) had @entity1 . CONCLUSIONS: The @entity2 and @entity1 prevalence among the @entity0 health service workers was of 75%.

title: [Overweight and @entity1 among health-professional XXXX ].

answer: @entity0


abstract: The mechanism of unidirectional retrograde atrioventricular (AV) @entity1 remains largely unknown. In this study, factors determining the reversal of the unidirectional block by @entity2 were evaluated in 12 @entity0 who had no demonstrable ventriculoatrial (VA) conduction during ventricular pacing. Six @entity0 demonstrated 1:1 VA conduction after @entity2 (group I), while the remaining six @entity0 continued to show @entity1 (group II). During the control study there was no significant difference in the sinus cycle length and AH interval between the two groups. The percent decrease in sinus cycle length after @entity2 was also similar in groups I and II (i.e., 23 +/- 12 and 26 +/- 6, respectively). The effect on antegrade AV nodal conduction (i.e., the percent decrease in AH interval), however, was significantly greater in group I (24 +/- 9) as compared to group II (9 +/- 5) (p less than 0.004). The onset of VA conduction appeared to correlate with the improvement of antegrade conduction. The ratio of these two effects of @entity2 (i.e., percent decrease in AH interval to percent decrease in sinus cycle length) was higher when VA conduction was first demonstrated in group I (2.3 +/- 1.1) than at the maximal effect of @entity2 (1.2 +/- 0.3), reflecting a relatively greater decrease in sinus cycle length. Three of six group I @entity0 redeveloped @entity1 at maximal effect of @entity2 . The results suggest a functional and dynamic nature of the unidirectional AV @entity1 , possibly caused by vagal influence exaggerating the well-known directional asymmetry of AV nodal conduction in @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Unidirectional retrograde atrioventricular @entity1 in XXXX : determinants of reversibility by vagal antagonism.

answer: @entity0


abstract: Low serum albumin level is associated with poor functional outcome and predicting a greater functional decline in the elderly. The aim of this study is to determine the interrelation between change of serum albumin level during rehabilitation period and functional outcome in @entity2 @entity0 . We studied 433 consecutive elderly @entity2 @entity0 admitted for rehabilitation. Functional outcome was assessed by the @entity4 ( @entity4 ) at admission and discharge of @entity0 with no @entity6 (<0 g/dl) or with positive @entity6 (>or=0 g/dl). Data were analyzed by t-test, Pearson correlation, chi(2)-test and linear regression. Of @entity0 66.7% showed no @entity6 . These @entity0 had a higher prevalence of previous @entity1 (p=0.04), lower Mini Mental State Examination (MMSE) scores (p=0.05) and were less likely to have @entity5 (p=0.008) compared with @entity0 with albumin gains. Admission and discharge @entity4 parameters and total and motor @entity4 gain/day were statistically significantly lower among @entity0 with no @entity6 . In a linear regression analysis total @entity4 at discharge was inversely associated with pre- @entity3 function (beta=-0.148; p<0.001), Albumin gain (beta=0.047; p=0.005), high MMSE score (beta=0.143; p<0.001), and higher admission total @entity4 score (beta=0.69; p<0.001) emerged as significant predictors of higher total @entity4 scores upon discharge. The results suggest that @entity0 with @entity6 have better admission and discharge @entity4 scores. Albumin gain emerged as a significant predictor for higher discharge @entity4 scores. We conclude that greater attention and efforts should be made regarding the dietary intervention and protein supplementation, in order to improve the rehabilitation outcome.

title: Rehabilitation outcome of XXXX @entity0 : the importance of a positive @entity6 .

answer: @entity2


abstract: UNASSIGNED: We assessed the effect of a transcatheter aortic valve replacement (TAVR) program and Heart Team concept on our approach to severe isolated @entity1 ( @entity1 ) with regard to surgical practice, @entity0 selection, perioperative outcomes, 1-year survival, and AVR volume. TAVR program began in August 2011. @entity0 having isolated surgical AVR between January 2008 and August 2011, when the program began (n = 282, 42 months), were compared with those after the program began until February 2015 (n = 344, surgical AVR and n = 126, TAVR, 42 months). Isolated surgical AVR accounted for 21% of all valve procedures (isolated and concomitant) before and after the TAVR program. However, the volume of all isolated AVR (surgical and transcatheter) increased to 27% of all valve procedures (isolated and concomitant) after the TAVR program implementation. Mean Society Of Thoracic Surgeons (STS)-predicted mortality risk was similar among @entity0 who had surgical AVR pre-TAVR and post-TAVR implementation (2.3% vs 2.1%, P = 0.227), but addition of @entity0 who had TAVR (STS risk = 7.1%) increased STS-predicted risk for all isolated AVR (surgical and transcatheter) procedures (2.3% vs 3.4%, P < 0.001). A similar trend was found for age, including a slight decrease in octogenarians for surgical AVR post-TAVR (18% vs 13%, P = 0.084). Operative mortality for isolated surgical AVR was similar in pre-TAVR and post-TAVR (2.1% vs 1.8%, P = 0.798), as were observed/expected (O/E) ratios (0.91 vs 0.82). For all isolated AVR, O/E ratio was 0.91 pre-TAVR and 0.82 post-TAVR (n = 470), including O/E = 0.79 for @entity0 who had TAVR. No changes were found in proportion of isolated surgical AVR cases or @entity0 risk and outcomes after introduction of TAVR program and Heart Team. However, volume of @entity0 with severe @entity1 treated increased significantly post-TAVR. Our results reflect growing awareness of TAVR availability and accompanying increases in @entity0 referred to our Heart Team for @entity1 treatment.

title: The Effect of Initiation of a Transcatheter Aortic Valve Replacement Program in the Treatment of Severe XXXX .

answer: @entity1


abstract: BACKGROUND: Helicopter transport may shorten transport time to neurosurgical intervention; however, there is little data regarding its utility for non-traumatic emergencies. METHODS: Pre-hospital and hospital records of all @entity0 transferred via helicopter to Dartmouth-Hitchcock Medical Center for spontaneous @entity1 between January 2007- December 2011 were reviewed. Primary outcome measure was emergent tertiary-level care intervention, defined as ventriculostomy, conventional angiography, endovascular treatment, or craniotomy within three hours of arrival. RESULTS: Fifty-one @entity0 met inclusion criteria. Median helicopter transport time, defined as time from telephone referral to arrival, was 97 minutes (range 61-214 minutes). Fifteen @entity0 underwent intervention within 3 hours of arrival (29%), 19 between 3 and 6 hours (37%), 9 between 6 to 12 hours (18%), and 11 greater than 12 hours after arrival (16%). Univariate analysis of pre-transfer clinical and radiographic findings showed significant correlations between GCS less than 15 (OR 22.8, 95%CI 4.2-122.5), WFNS scale greater than 2 (OR 46.75, 95%CI 7.511-290.99), presence of @entity2 (OR 4.7, 95%CI 1.3-17.5), and intubation (OR 12.4, 95%CI 2.9-51.8) with emergent intervention. On logistic multivariate regression analysis, GCS less than 15 and WFNS scale greater than 2 independently predicted emergent intervention. CONCLUSIONS: A majority of @entity0 with spontaneous @entity1 who were transferred by inter-facility helicopter ambulance did not require emergent intervention. GCS less than 15 at an outside hospital was independently associated with emergent intervention on multivariate analysis.

title: Pre-hospital Glasgow Coma Score predicts emergent intervention following helicopter transfer for spontaneous XXXX .

answer: @entity1


abstract: 1 Intracellular recordings were made from smooth muscle cells of the @entity0 vas deferens. Excitatory junction potentials (e.j.ps) were evoked by stimulation of the intramural nerves. 2 @entity4 (50 nM-5muM) depressed the amplitude of the e.j.p. The ED50 was 430 nM. The latency of the e.j.p. and the resting membrane potential of the smooth muscle cells were unaffected by @entity4 . 3 The @entity1 of the e.j.p. by narcotic analgesic drugs was stereospecific. 4 @entity3 (100 nM) completely reversed the @entity1 of the e.j.p. produced by @entity4 (1 muM). @entity3 (100 nM) alone did not alter the amplitude of the e.j.p. 5 @entity4 (1 muM) did not prevent the depolarization of the smooth muscle cells produced by exogenous @entity2 (10 muM). 6 It is concluded that narcotic analgesic drugs act directly upon the transmitter release sites to reduce the amount of @entity2 liberated by each nerve impulse.

title: XXXX by morphine of excitatory junction potentials in the vas deferens of the @entity0 .

answer: @entity1


abstract: UNASSIGNED: Diffusion tensor imaging (DTI) studies of @entity0 brain development have consistently shown widespread, but nonlinear increases in white matter anisotropy through childhood, adolescence, and into adulthood. However, despite its sensitivity to changes in tissue microstructure, DTI lacks the specificity to disentangle distinct microstructural features of white and gray matter. Neurite orientation dispersion and density imaging (NODDI) is a recently proposed multi-compartment biophysical model of brain microstructure that can estimate non-collinear properties of white matter, such as neurite orientation dispersion index (ODI) and @entity1 ( @entity1 ). In this study, we apply NODDI to 66 healthy controls aged 7-63 years to investigate changes of ODI and @entity1 with brain maturation, with comparison to standard DTI metrics. Using both region-of-interest and voxel-wise analyses, we find that @entity1 exhibits striking increases over the studied age range following a logarithmic growth pattern, while ODI rises following an exponential growth pattern. This novel finding is consistent with well-established age-related changes of FA over the lifespan that show growth during childhood and adolescence, plateau during early adulthood, and accelerating decay after the fourth decade of life. Our results suggest that the rise of FA during the first two decades of life is dominated by increasing @entity1 , while the fall in FA after the fourth decade is driven by the exponential rise of ODI that overcomes the slower increases of @entity1 . Using partial least squares regression, we further demonstrate that NODDI better predicts chronological age than DTI. Finally, we show excellent test-retest reliability of NODDI metrics, with coefficients of variation below 5% in all measured regions of interest. Our results support the conclusion that NODDI reveals biologically specific characteristics of brain development that are more closely linked to the microstructural features of white matter than are the empirical metrics provided by DTI.

title: White Matter Changes of Neurite Density and Fiber Orientation Dispersion during XXXX Brain Maturation.

answer: @entity0


abstract: The aim of this study is to define the burden of @entity2 requiring hospitalization among adults in Lazio region from 1997 to 1999 and to describe the characteristic of community acquired ( @entity7 ), suspected nosocomial (NP) and in @entity4 . The data source is the hospital discharge register. 30517 incident episodes of @entity2 hospitalization occurred in the three years period, 20497 @entity7 , 9760 NP and 964 in @entity4 of which 704 supposed to be acquired in hospital; the mean age is 65, 69 and 38 years respectively. Standardized hospitalization rates for @entity7 do not show a clear geographical pattern, while for NPs and in @entity4 they are higher in the city of Rome than in the rest of the region. There are peaks of incidence during the winter for CAPs and NPs but not for @entity4 . Only 20% of @entity2 have etiological diagnosis. The proportional analysis of aetiological agents shows: pneumococcus, @entity6 , staphylococci and @entity3 ; the most frequent comorbidities are: circulatory diseases, @entity5 ( @entity5 ), @entity0 and @entity1 . 3.9% of individuals in the study with @entity7 or NP had more than one episode of @entity2 during the study period, for those with @entity2 in @entity4 this percentage was 14.8. In-hospital lethality is 9.4%, 29.3% and 11.2% for @entity7 , NP and in @entity4 , respectively. Data from the hospital discharge registers can be used to give a cheap and rapid glimpse to the epidemiology of pathologies frequently requiring hospitalisation neglected from more analytical surveillance systems or registries.

title: [Hospitalization for XXXX in adults. Lazio, 1997-1999].

answer: @entity2


abstract: From 1981 to 1987, 62 @entity0 with @entity5 and associated @entity4 required treatment after unsuccessful initial medical therapy (51 @entity0 ) and previous surgical therapy (11 @entity0 ). Surgical options included direct revascularization (group I, 11 @entity0 ), endocardial resection (group II, 7 @entity0 ), @entity2 (group III, 18 @entity0 ), and these combinations of operations: revascularization and endocardial resection (group IV, 18 @entity0 ), revascularization and insertion of @entity2 (group V, 5 @entity0 ), and endocardial resection and insertion of @entity2 (group VI, 3 @entity0 ). Five underwent repeat revascularization (4) or endocardial resection (4) with mitral valve replacement (1) or papillary muscle reconstruction (2). The overall operative mortality of 8.1% (5/62) has been acceptable (2.8% or 1/36 for the simple procedures [groups I, II, and III] and 15.4% or 4/26 for the combined procedures [IV, V, and VI]; p less than 0.074). Operative risk factors included recent @entity3 (4/5 @entity1 ) and depressed ejection fraction of 23% or less (5/5 @entity1 ). These operative risks were highest in group IV and, thus, the highest mortality was in group IV (4/18 @entity0 or 22%, p less than 0.022). Six late @entity1 (4 @entity0 in group III) brought the overall survival rate to 82% or 51/62 @entity0 at a mean follow-up of 30 months. Surgical treatment of @entity4 requires a planned, combined operative approach, since initial medical or surgical failures can occur. The optimal surgical approach requires complete revascularization, resection of the localized subendocardial arrhythmogenic focus, and ventricular reconstruction. An @entity6 is a palliative alternative for less favorable surgical anatomy and for @entity0 who are poor operative candidates for these combined or reoperative procedures.

title: Surgical options for treating @entity5 and XXXX .

answer: @entity4


abstract: BACKGROUND: The development of @entity5 is not only associated with @entity6 and extracellular matrix remodeling, but also with @entity2 . The aim of this study was to determine the role of proinflammatory signaling through the leukotriene (LT) pathway in @entity5 . METHODS AND RESULTS: After macroscopic dissection of surgically removed @entity0 aortic valves, RNA was extracted from 311 preparations derived from 68 @entity0 to differentiate normal, thickened, and calcified areas from each cusp. Subsequently, quantitative polymerase chain reaction analysis was used to correlate gene expression patterns with preoperative echocardiographic parameters. The messenger RNA levels of the LT-forming enzyme @entity8 increased 1.6- and 2.2-fold in thickened and calcified tissue, respectively, compared with normal areas of the same valves. In thickened tissues, messenger RNA levels for @entity8 (r= -0.35; P=0.03), its activating protein @entity8 activating protein; r= -0.39; P=0.02), and @entity9 (r= -0.48; P=0.01) correlated inversely with the velocity-time integral ratio. In addition, @entity9 transcripts correlated inversely with aortic valve area, indexed for body surface area (r= -0.52; P=0.007). Immunohistochemical stainings revealed LT receptor expression on valvular myofibroblasts. In primary cultures of @entity0 myofibroblasts derived from stenotic aortic valves, @entity3 (LTC(4)) increased intracellular @entity4 , enhanced reactive @entity1 species production, reduced the mitochondrial membrane potential, and led to morphological cell cytoplasm changes and @entity6 . CONCLUSIONS: The upregulation of the LT pathway in @entity0 @entity5 and its correlation with clinical @entity7 severity, taken together with the potentially detrimental LT-induced effects on valvular myofibroblasts, suggests one possible role of @entity2 in the development of @entity5 .

title: Upregulation of the @entity8 pathway in @entity0 aortic valves correlates with severity of XXXX and leads to leukotriene-induced effects on valvular myofibroblasts.

answer: @entity7


abstract: BACKGROUND: Epiphrenic @entity9 of the esophagus are often associated with a concomitant @entity2 , which is thought to be the cause of the diverticulum and some of the @entity0 's symptoms. At one time @entity9 were best removed via a left thoracotomy, but now the operation can be performed laparoscopically in most cases. We hypothesized that: (1) a @entity5 is the underlying cause of the diverticulum; and (2) optimal treatment consists of laparoscopic resection of the diverticulum, a Heller myotomy, and @entity7 fundoplication. METHODS: We performed a retrospective review of a prospectively collected database from a university hospital tertiary care center. Between June 1994 and December 2002, we evaluated 21 @entity0 with @entity9 . An associated @entity4 of the esophagus was found in 81% of @entity0 ( @entity3 , 9%; diffuse esophageal @entity6 , 24%; nonspecific @entity8 , 24%; nutcracker esophagus, 24%). Seven (33%) of these @entity0 , all with @entity8 , were referred for treatment. The laparoscopic operation entailed resection of the diverticulum (using an endoscopic stapler), a Heller myotomy, and a @entity7 fundoplication. RESULTS: All operations were completed laparoscopically. The postoperative course of 6 @entity0 was uneventful and they left the hospital after 72 +/- 21 hours. In 1 @entity0 an acute @entity1 developed, which was repaired on the second postoperative day. Late follow-up (median 57 months) showed that all 7 @entity0 were asymptomatic. CONCLUSIONS: These data support the conclusions that: (1) a primary @entity8 is the underlying cause of most @entity9 ; and (2) laparoscopic treatment is successful and should be the method of choice. The diverticular neck can be exposed satisfactorily from the abdomen; a stapler inserted from this angle is better orientated to transect the neck than one inserted through a thoracoscopic approach. Furthermore, the myotomy and fundoplication are much more easily performed from the abdomen than from alternative approaches.

title: Cause and treatment of XXXX .

answer: @entity9


abstract: OBJECTIVES: To determine predictors for surgical outcome in the presurgical assessment of @entity2 . METHODS: Thirty seven @entity0 were operated on for @entity2 between 1975 and 1996. Their medical records were reviewed for ictal semiology, age at onset, duration of the @entity1 , age at operation, preoperative interictal and ictal encephalographic findings, and abnormalities on neuroimaging and neuropsychological testing. In addition, type of resection and pathology were compared with surgical outcome. RESULTS: Univariate statistical analysis showed that the presence of a focal abnormality on neuroimaging was associated with favourable outcome. The presence of the following ictal findings was associated with poor outcome: autonomic manifestations, eye deviation, head version contralateral to the operated side, and bilateral or multifocal ictal onset. Fifteen @entity0 had secondarily generalised interictal discharges and, interestingly, their presence was not associated with poor outcome. Multivariate logistic regression showed that the presence of a focal abnormality on neuroimaging was significantly associated with a favourable outcome while contralateral head version was the only variable significantly associated with poor surgical outcome. CONCLUSIONS: A focal abnormality on neuroimaging was the only variable which was significantly associated with a favourable surgical outcome, whereas contralateral head version was the most significant predictor for a poor outcome. The presence of generalised discharges before surgery was not associated with poor outcome.

title: Prognostic factors in presurgical assessment of XXXX .

answer: @entity2


abstract: @entity7 ( @entity10 ) is a glucocorticoid produced by adrenal glands under the control of the @entity6 . Circulating @entity10 can enter the central nervous system and be reduced to neuroactive 3a5a-reduced @entity3 , which modulate GABAA receptors. In the dorsal spinal cord, GABAergic transmission modulates integration of nociceptive information. It has been shown that enhancing spinal inhibitory transmission alleviates @entity5 and @entity5 . Therefore, the spinal neuronal network is a pivotal target to counteract @entity2 symptoms. Thus, any increase in spinal 3a5a-reduced @entity1 production enhancing GABAergic inhibition should reduce nociceptive message integration and the @entity2 response. Previously, it has been shown that high levels of plasma glucocorticoids give rise to @entity4 . However, to our knowledge, nothing has been reported regarding direct non-genomic modulation of neuronal spinal activity by peripheral @entity10 . In the present study, we used combined in vivo and in vitro electrophysiology approaches, associated with measurement of nociceptive mechanical sensitivity and plasma @entity10 level measurement, to assess the impact of circulating @entity10 on @entity0 nociception. We showed that @entity10 plasma level elevation produced @entity4 via a reduction in @entity8 -mediated spinal responses. In the spine, @entity10 is reduced to the neuroactive metabolite @entity9 , which specifically enhances lamina II GABAergic synaptic transmission. The main consequence is a reduction in lamina II network excitability, reflecting a selective decrease in the processing of nociceptive inputs. The depressed neuronal activity at the spinal level then, in turn, leads to weaker nociceptive message transmission to supraspinal structures and hence to alleviation of @entity2 .

title: @entity7 XXXX is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn @entity0 neurons.

answer: @entity4


abstract: BACKGROUND: ABO autoantibodies are rare. Most reported examples have been antibodies with 4 degrees C titers not greater than 256 in @entity0 without apparent @entity1 . Most high-titer, high-thermal-amplitude, complement-activating cold agglutinins are associated with @entity1 . STUDY DESIGN AND METHODS: A 52-year-old @entity0 presented with acrocyanosis and mild @entity2 , but no evidence of obvious @entity1 . Regular plasmapheresis treatment was helpful in relieving the clinical symptoms associated with acrocyanosis. Serologic methods were used to study the @entity0 's RBCs and sera. RESULTS: The @entity0 's RBCs were strongly reactive with anti-C3 and anti-IgM and weakly reactive with anti-IgA. The patient's serum contained a high-titer, high-thermal-amplitude, IgMkappa autoanti-B, capable of activating complement in vitro. CONCLUSION: A @entity0 with a powerful ABO autoantibody is described. This @entity0 had acrocyanosis but did not appear to have an obvious @entity1 . This case is a good example of the lack of correlation between in vitro serologic tests and in vivo reactions in individual @entity0 .

title: A high-titer, high-thermal-amplitude autoanti-B associated with acrocyanosis but no obvious XXXX .

answer: @entity1


abstract: Activation of FGFR signaling through mutations, amplifications, or fusions involving @entity7 , 2, 3, or 4 is seen in @entity1 , including lung, bladder, and @entity4 . Currently, several clinical trials are evaluating the role of novel FGFR inhibitors in solid @entity1 . As we move forward with FGFR inhibitors clinically, we anticipate the emergence of resistance with treatment. Consequently, we sought to study the mechanism(s) of acquired resistance to FGFR inhibitors using annotated @entity1 cell lines. We identified @entity1 cell lines that have activating mutations in @entity7 , 2, or 3 and treated them chronically with the selective FGFR inhibitor, @entity8 . We observed resistance to chronic @entity8 exposure in @entity0 ( @entity2 , @entity7 amplification) and RT112 ( @entity3 , @entity6 fusion/amplification) cell lines based on viability assays. Reverse-phase protein array (RPPA) analysis showed increased phosphorylation of @entity5 (T308 and S473) and its downstream target GSK3 (S9 and S21) in both the resistant cell lines when compared with matching controls. Results of RPPA were confirmed using immunoblots. Consequently, the addition of an @entity5 inhibitor ( @entity9 ) or siRNA was able to restore sensitivity to @entity8 in resistant cell lines. These data suggest a role for @entity5 pathway in mediating acquired resistance to FGFR inhibition. Mol Cancer Ther; 1-11.   2017 AACR.

title: XXXX Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor @entity8 .

answer: @entity5


abstract: OBJECTIVE: We present a treatment for recurrent, symptomatic @entity3 in @entity0 with @entity1 . This report summarizes our experience with percutaneous tunneled peritoneal catheters in 24 @entity0 . SUBJECTS AND METHODS: Of the 40 consecutive @entity0 who presented with at least four therapeutic paracenteses in a 4-week period, 24 @entity0 underwent the percutaneous tunneled procedure. All had @entity1 . RESULTS: All 24 @entity0 had successful insertion of a permanent tunneled peritoneal drainage catheter. Eighteen were outpatients and six were inpatients. All @entity0 were relieved of their clinical symptoms, including @entity5 and @entity4 , and were relieved of lower extremity discomfort. The mean life span after catheter placement was 7.2 weeks. Twenty (83%) of the 24 @entity0 were treated at home with their catheters in place. Three @entity0 experienced minor complications from @entity2 , which responded to antibiotics. One @entity0 had to have his catheter removed. CONCLUSION: Percutaneous placement of specialized tunneled catheters appears to be a viable and safe technique in @entity0 who have symptomatic @entity3 that require frequent therapeutic paracentesis for relief of symptoms.

title: Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: Evidence supports the validity of individual components of the @entity4 model in the context of @entity5 . However, there is a need to test the inter-relationships amongst measures of individual components of @entity4 in a more integrative manner. In particular, research is needed to examine whether a model with discrete facets as proposed is indeed reflected in data from currently used assessment measures in @entity0 with @entity5 . PURPOSE: This cross-sectional study investigated the underlying structure of measures of processes of @entity4 amongst individuals with @entity5 and the associations between this measurement model and @entity0 functioning. METHODS: Five-hundred and seventy-three adults with @entity5 completed measures of @entity2 , physical and social functioning, mental health, @entity3 and processes of @entity4 , including acceptance, @entity1 , decentering and committed action. Confirmatory factor analyses tested lower-order, higher-order and bifactor models to examine the structure of @entity4 process measures. RESULTS: A single general factor reflecting @entity6 explained variability in items across all of the @entity4 process measures. In addition to this general factor, distinct decentering and committed action group factors emerged in the data. As expected, the general factor was strongly correlated with measures of social functioning, mental health and @entity3 . CONCLUSIONS: Future research is needed to determine the most useful means by which the presence of the general factor can be reflected in the measurement and theory of @entity4 .

title: A Confirmatory Factor Analysis of Facets of Psychological Flexibility in a Sample of @entity0 Seeking Treatment for XXXX .

answer: @entity5


abstract: Previous studies have shown that laparoscopic interventions are associated with increases in intracranial pressure. However, the consequences on cerebral blood flow (CBF) are unknown. This study investigates the effects of @entity3 ( @entity1 ) @entity2 on CBF in @entity4 . Ten @entity4 (weight, 20-26 kg) were anesthetized with 1.4% @entity7 and @entity5 (1 microg/kg per minute). Mechanical ventilation (fraction of inspired @entity0 = 0.4) was set to maintain normocapnia (end-tidal @entity1 tension = 35 mm Hg). Arterial and central venous catheters were placed for measurement of mean arterial blood pressure and central venous pressure. Bilateral internal carotid artery blood flow was measured using two transient time flow probes placed around both carotid arteries (with ligated external carotid arteries). Cortical and subcortical cerebral blood flow was measured using laser Doppler flowmetry. Sagittal sinus pressure was measured via a superior sagittal sinus catheter. After baseline measurements, the peritoneal cavity of the animals was insufflated with @entity1 to achieve an intraabdominal pressure of 12-mm Hg. After 10 minutes of stable @entity1 , @entity2 measurements were repeated. Increases in central venous pressure (6.3 +/- 2.1 to 11.1 +/- 3.0 mm Hg) and sagittal sinus pressure (8.0 +/- 2.8 to 11.9 +/- 3.0 mm Hg) were noted during @entity1 @entity2 (P < .05). Bilateral internal carotid artery blood flow (46.0 +/- 7.4 vs 47.7 +/- 7.1 mL/100g per minute), cortical CBF (263 +/- 115 vs 259 +/- 158 tissue perfusion units), and subcortical CBF (131 +/- 145 vs 133 +/- 149 tissue perfusion units) did not change during @entity1 @entity2 . The current data show that @entity1 @entity2 increases sagittal sinus pressure without changing CBF. Increases in sagittal sinus pressure are likely related to @entity6 caused by increases in intraabdominal pressure.

title: Effects of XXXX @entity2 on cerebral hemodynamics in @entity4 .

answer: @entity3


abstract: @entity0 with the clinical syndrome of @entity8 as a result of Toxocara species have typical @entity3 , consisting of palisading @entity5 that contain numerous eosinophils and often Charcot-Leyden crystals; recognizable parasites are uncommon. Similar @entity6 that are found incidentally in adults often cause diagnostic problems. To define better the clinical, laboratory, and pathologic features of these lesions, we reviewed 43 cases of hepatic @entity6 (excluding cases of Langerhans' cell histiocytosis) collected in the files of the AFIP over a period of 31 years. The @entity6 were found in @entity0 of all ages (range 12 months to 77 years); 30% were younger than 20 years. There were 26 male and 17 female @entity0 . Most @entity0 (26 of 43; 60%) were asymptomatic, and the lesions were discovered incidentally. Others had @entity2 (20%) or @entity4 (20%). The @entity5 were typically multiple (61%), with central @entity1 surrounded by a mixed inflammatory infiltrate with numerous eosinophils and variable numbers of neutrophils. lymphocytes, and a palisade of epithelioid histiocytes and/or giant cells. Charcot-Leyden crystals were present in 19 cases (44%). Remnants of parasites (eight Toxocara sp., two Capillaria sp.) were identified in the tissue in 10 @entity0 . There was a positive serologic test for Toxocara sp. in five additional cases. Immunohistochemical staining using polyclonal antiserum against @entity7 larvae demonstrated positivity in macrophages in eight of 13 cases tested. We conclude that identification of an @entity6 in the liver should suggest the diagnosis of @entity8 and prompt a search for the causative organism with serial sectioning of the block and serologic tests for Toxocara and other causative parasites.

title: XXXX : a characteristic lesion with relationship to @entity8 .

answer: @entity3


abstract: @entity1 growth and @entity0 are determined by the complex interplay of factors, including those @entity1 cells and extrinsic factors associated with the @entity1 microenvironment. Our previous work demonstrated key roles for @entity4 in the maintenance of vascular integrity and eosinophil and mast cell homing. Since both of these functions affect @entity1 development, we characterized the effect of @entity4 ablation on @entity1 growth using the B16F1 @entity3 model. Intriguingly, we found that @entity4 plays a biphasic role in @entity1 progression. In early growth, both subcutaneous-injected @entity1 and intravenous-injected lung metastases grew more slowly in @entity4 (-/-) @entity2 . This correlated with abnormal vessel morphology and increased vascular permeability in these @entity2 . Bone marrow transplantation experiments confirmed that this reflects a non-hematopoietic function of @entity4 . At later stages, subcutaneous @entity1 growth was accelerated in @entity4 (-/-) @entity2 and surpassed growth in wildtype @entity2 . Bone marrow chimera experiments demonstrated this difference was due to a hematopoietic function for @entity4 and, correspondingly we found @entity1 mast cell numbers in @entity4 (-/-) @entity2 . In aggregate, our analysis reveals a novel role for @entity4 in both early and late @entity1 growth and provides novel insights into the role of the @entity1 microenvironment in @entity1 progression.

title: Opposing roles for XXXX in B16 @entity3 growth alter early stage vasculature and late stage immune cell infiltration.

answer: @entity4


abstract: The analysis of clusters of @entity2 -scarce states formation among the @entity0 's population of the Saratov Region is submitted. The hygienic assessment of @entity2 content in raw food materials and foodstuffs grown up and made on the territory of the Saratov Region is given. It has been revealed that various food groups were characterized by a low @entity2 content, which was (mcg/100 g) in the bread--4.5 +/- 1.0; 3,6 +/- 0.8 in @entity3 grain; 2.7 +/- 0.6 in buckwheat; 2.5 +/- 1.1 in beans; 1.95 +/- 0.9 in @entity4 . The actual @entity2 content in local vegetables and fruits was 1.3-1.6 fold below than the standard chemical composition according to the national tables, in river fish--twice. The quality analysis of the iodated salt sold in the trading network has been carried out. It has been found out that the use of the iodated salt with low @entity2 content has decreased the additional direct population risk from 12.34% in 2000 to 0.48% in 2010. For the last few years the use of the iodated salt tends to increase in the Saratov Region. In 2011 the iodated salt was used by 37.2% of urban population and 29.0% of villagers. In 2011 88.6% of school students were provided with the iodated salt in educational institutions of the area. It has been shown that the formation of mass @entity2 -scarce states among the population in the Saratov Region has lasted for a long time. The screening researches of urine excretion in the organized groups of surveyed @entity0 revealed an average level of @entity2 @entity1 . In 2011 the @entity2 @entity1 of moderate degree was registered in 18 areas of the Saratov Region, in 6--of easy degree, whereas the moderately severe @entity1 areas were not registered.

title: [Hygienic aspects of XXXX in the @entity0 's population of the Saratov region].

answer: @entity1


abstract: @entity0 , in India, is the second commonest @entity2 in females. Receptor status with ER/PR/ @entity5 is now routinely done in @entity1 with @entity3 . The @entity2 suppressor gene, @entity4 , is also present in most @entity0 . Proteins produced by a mutated @entity4 gene, accumulate in the nucleus of @entity2 cells and are detected by immunohistochemistry (IHC). We have undertaken this study with the aim to evaluate the ER, PR, @entity5 and @entity4 expressions in invasive @entity0 by IHC and to compare the @entity5 expression with various clinicopathological parameters. MATERIALS AND METHODS: In this retrospective single institutional study from January 2001 to December 2010, 389 cases of histopathologically diagnosed infiltrating @entity0 were evaluated taking into account various parameters like age, @entity2 size, grade, lymph node involvement, ER and PR. @entity5 and @entity4 was done in 352 cases. RESULTS: The age range was 23-90 years with a mean of 50.7 years. @entity2 were T2 (79.6%) and Grade II (60.9%). Our data showed overall 47.6% ER, 48.8% PR, 29.6% @entity5 and 69.2% @entity4 positivity. There was no significant correlation between @entity5 and age, @entity2 size, lymph node status, ER, and PR. There was significant correlation between @entity5 and @entity2 grade (P = 0.031), @entity4 (P < 0.001). There was no inverse correlation between @entity5 and combined ER, PR status. @entity0 which constituted 22.7% of our cases did not reveal any correlation with various parameters. CONCLUSION: In our study, ER status was low, and incidence of @entity4 was high. These findings suggest that many of the @entity2 in Indian females may be of an aggressive type, and novel treatment approaches may be tried. We conclude that the assessment of all four markers is desirable.

title: Hormone receptor status (estrogen receptor, progesterone receptor), @entity1 epidermal growth factor-2 and XXXX in South Indian @entity0 @entity1 : A tertiary care center experience.

answer: @entity4


abstract: Thyroid hormones are required for the normal development of skeletal muscle in utero, although their mechanism of action is poorly understood. The present study examined the effects of the thyroid hormones on the gene expression of the @entity6 ( @entity6 ) and the insulin-like growth factors (IGFs) @entity3 and @entity4 , in skeletal muscle of fetal @entity1 during late gestation (term 145 +/- 2 days) and after manipulation of plasma thyroid hormone concentration. Thyroidectomy at 105-110 days of gestation suppressed muscle @entity6 and @entity3 gene expression in fetuses studied at 127-130 and 142-145 days. Muscle @entity6 mRNA abundance remained unchanged with increasing gestational age in intact and thyroidectomized fetuses. In the intact fetuses, a decrease in muscle @entity3 gene expression was observed between 127-130 and 142-145 days, which coincided with the normal prepartum surges in plasma @entity0 and @entity2 (T3). At 127-130 days, downregulation of muscle @entity3 mRNA abundance was induced prematurely in intact fetuses by an infusion of @entity0 for 5 days (2-3 mg x kg(-1) x day(-1) iv), which increased plasma @entity0 and T3 concentrations to values seen near term. However, increasing plasma T3 alone by an infusion of T3 for 5 days (8-12 microg x kg(-1) x day(-1) iv) in intact fetuses at this age had no effect on @entity6 or @entity3 gene expression in skeletal muscle. In the thyroidectomized fetuses, no additional change in the low level of muscle @entity3 mRNA abundance was seen with increasing gestational age, but at 127-130 days, @entity3 gene expression was reduced further when plasma @entity0 and T3 concentrations were increased by exogenous @entity0 infusion. Muscle @entity4 mRNA abundance was not affected by thyroidectomy, gestational age, or exogenous hormone infusion. These findings show, in the @entity1 fetus, that thyroid hormones may influence the growth and development of skeletal muscle via changes in the local activity of the @entity5 .

title: Thyroid hormones and the mRNA of the @entity6 and IGFs in skeletal muscle of fetal XXXX .

answer: @entity1


abstract: Protective immunity to the @entity11 , @entity11 , has been demonstrated by immunization of pigs with antigens derived from the parasite's larval stages. We identified a protective antigen commonly expressed in the @entity0 and @entity6 Ascaris infections as a 16-kDa protein (As16), which has no similarity at the @entity4 level to @entity0 proteins but has some similarity to those of the filarial parasites and @entity7 gene product. Localization analysis revealed that the native As16 was highly expressed in the adult worm intestine, hypodermis, and cuticles. In addition, As16 was detected in the parasite excretory and secretory products. @entity1 intranasally vaccinated with @entity3 -expressed recombinant As16 (rAs16), coupled with cholera toxin B subunit, generated a significant increase in the level of rAs16-specific immunoglobulin G (IgG) and IgE in serum. Mucosal IgA levels were also increased. The recombinant protein evoked a mixed (both @entity5 and @entity2 ) type of immune response characterized by elevated levels of gamma interferon and interleukin-10 in the culture supernatants of activated spleen cells. An increased level of @entity9 and @entity10 in serum was also observed. The vaccinated @entity1 showed a reduction by 58% in the recovery of challenged larvae compared to a nonvaccinated control. These results suggest the possibility of developing a mucosal vaccine for @entity0 and @entity6 @entity8 .

title: @entity1 intranasally immunized with a recombinant 16-kilodalton antigen from @entity7 Ascaris parasites are protected against larval migration of XXXX .

answer: @entity11


abstract: UNASSIGNED: 3708 Background: Administrative databases have generally not been designed to permit @entity1 researchers to readily follow @entity0 forward from the period pre-diagnosis through initial curative intent treatment, adjuvant therapy, post-treatment follow-up, to the final endpoint of either @entity3 or loss to follow-up. One major hurdle to @entity1 research using such databases has been the lack of data such as stage at diagnosis, and histopathologic type and grade. A second major hurdle is that many @entity0 use more than one system of care, in this instance, Department of Veterans Affairs (VA) and Medicare-reimbursed care. These dual users would be inaccurately represented in the analysis if only one source of data were analyzed. METHODS: A retrospective analysis of 13 years of nationwide Medicare and VA inpatient and institutional outpatient data beginning with the three years pre-diagnosis (1986-1990) through a minimum of five years post-diagnosis (1994-1998) was conducted. Death data were available through December 2003. Data were also extracted from @entity1 registry files, Computerized @entity0 Record System Files, and paper medical records at each VA. The population studied included all VA @entity0 diagnosed with @entity2 and surgically treated for cure during the five-year period 1989-1993, who were Medicare-eligible at diagnosis, and survived the index admission. RESULTS: Of the 6612 @entity0 treated with curative intent during the five-year period, 4902 (74%) could be staged. Of these, 4535 (93%) were deemed eligible for the study. Of the eligible @entity0 , 77% were diagnosed with @entity5 and 23 percent with @entity1 . The majority (88%) had @entity4 . The histopathologic grade was moderately differentiated for 54% and well differentiated for 19%. As of December 2003, 74% had died. Including all stages (0- IV), the average survival in months after treatment was 75 (median=61). CONCLUSIONS: This rich database provides a wealth of data for subgroup analyses of survival, recurrence patterns, and particularly, of health services utilization patterns within and across systems of care. [Table: see text].

title: Long-term survival patterns of a large nationwide cohort of elderly veterans with XXXX .

answer: @entity2


abstract: A microalgal biomass offers a potential alternative to the @entity1 silage commonly used in biogas technology. In this study, photoautotrophically grown @entity2 was used as biogas substrate. This microalga has a low C/N ratio of 8.5 relative to the optimum 20-30. A significant increase in the @entity3 ion content was not observed. The @entity0 content of the biogas generated from Sc. obliquus proved to be higher than that from @entity1 silage, but the specific biogas yield was lower. Semi-continuous steady biogas production lasted for 2 months. Because of the thick cell wall of Sc. obliquus, the biomass-degrading microorganisms require additional time to digest its biomass. The @entity0 concentration in the biogas was also high, in co-digestion (i.e., 52-56%) as in alga-fed anaerobic digestion (i.e., 55-62%). These results may be related to the relative predominance of the order Clostridiales in co-digestion and to the more balanced C/N ratio of the mixed algal- @entity1 biomass. Predominance of the order Methanosarcinales was observed in the domain Archaea, which supported the diversity of metabolic pathways in the process.

title: Metagenome changes in the mesophilic biogas-producing community during fermentation of the green alga XXXX .

answer: @entity2


abstract: Recombinant @entity0 deoxyribonuclease (rhDNase) has been shown to reduce sputum viscoelasticity and to improve lung function in @entity0 with @entity3 ( @entity3 ). The aim of this study was to determine whether @entity1 would decrease after administration of rhDNase. Twenty @entity0 with @entity3 and @entity2 inhaled 2.5 mg of rhDNase daily for 1 month. Before and after the 1-month trial, lung function was measured and sputum was obtained, either after spontaneous expectoration or after sputum induction with hypertonic saline. Sputum total cell and differential counts were measured using techniques previously described. The mean age of the @entity0 was 16.8 years (range, 6.7-27.5). After 1 month of rhDNase, mean FEV1 increased from a baseline of 62.3% predicted to 70.8% (P= 0.02, paired t test); and FVC increased from 74.4% to 83.9% predicted (P=0.007). No significant differences were found in sputum cytology before or after rhDNase (median total cell counts 16.0 x 10(6)/ml vs. 19.3 x 10(6)/ml, P=0.68). Thirteen @entity0 had a 10% or greater increase in FEV1 after rhDNase (responders). Initial lung function was less in responders than in nonresponders (53.5% vs. 78.6%, P=0.007). There was no significant change in total cell count and neutrophil count after rhDNase in either responders or nonresponders. We conclude that @entity1 , as measured by total cell counts in sputum, was a prominent feature in @entity3 , and neutrophils were the dominant inflammatory cells. Although the administration of rhDNase resulted in significant improvements in FEV1, there was no evidence of accompanying changes in @entity1 .

title: XXXX after treatment with aerosolized deoxyribonuclease in @entity3 .

answer: @entity1


abstract: BACKGROUND: The purpose was to determine the factors influencing nodal involvement and topography of pelvic and paraaortic node @entity3 . STUDY DESIGN: Between 1985 and 2001, 276 @entity0 with @entity3 underwent systematic bilateral pelvic and paraaortic lymphadenectomy. RESULTS: The overall frequency of lymph node involvement was 44% (122 of 276). The frequency of pelvic and paraaortic @entity1 were 30% (82 of 276) and 40% (122 of 276), respectively. The frequency of lymph node @entity1 according to the stage of the disease (stages I, II, and III + IV) were: 20% (17 of 85), 40% (6 of 15), and 55% (99 of 176), respectively. In @entity0 with stage IA, IB, and @entity4 , the rates of nodal involvement were 13% (8 of 60), 33% (4 of 12), and 38% (5 of 13), respectively. None of 15 @entity0 with stage IA grade 1 disease had nodal involvement. None of the 20 @entity0 with @entity2 confined to the ovary(ies) (stage I disease) had nodal involvement. When paraaortic nodes were involved, the left paraaortic chain above the level of the inferior mesenteric artery was the most frequently involved site (70 @entity0 , 63%). One of nine @entity0 (11%) with a macroscopic stage I @entity2 and paraaortic involvement had contralateral @entity1 . CONCLUSIONS: Lymphadenectomy should be performed even in @entity0 with stage IA disease. This procedure could be omitted in @entity0 with mucinous apparent stage I disease and stage I grade 1 @entity2 . Lymphadenectomy should involve the whole pelvic and paraaortic chain up to the level of the left renal vein. A bilateral dissection should be performed even in cases of @entity0 with a @entity2 .

title: Lymph node involvement in XXXX : analysis of 276 pelvic and paraaortic lymphadenectomies and surgical implications.

answer: @entity3


abstract: INTRODUCTION: At present, there is no obligatory guideline for the prevention of early-onset neonatal group B streptococcal disease in Hungary. AIM: The aim of the present study was to gain insight into the spontaneously developed preventive strategy of the domestic obstetric divisions and departments in Hungary. METHOD: Standardized questionnaire was sent out to each of the 71 obstetric divisions and departments in Hungary. RESULTS: Overall, 20 (27.4%) of the chairpersons replied, and thus, 39.9% of the total number of live births in Hungary were included in the study. Despite missing public health guidelines, each of the divisions and departments developed their own strategy to prevent neonatal group B streptococcal disease. In 95% of cases, bacterial culture of the lower vagina was the method of identifying pregnant @entity0 at risk. In 5% of the cases intrapartum antibiotic prophylaxis was based on risk assessment only. Of the departments using culture-based prophylaxis, 58% departments sampled @entity0 after completion of 36th gestational weeks. Antibiotic of choice was @entity1 or @entity2 in 100% of cases. Of the study @entity0 , 80% reported on multiple administration of colonized pregnant @entity0 after onset of labor or rupture of the membranes. CONCLUSIONS: The authors concluded that the rate of participation in the study was low. However, prevention of early-onset neonatal group B @entity3 is a priority of obstetric care in Hungary. Lack of a nation-wide public health policy did not prevent obstetric institutions in this country to develop their own prevention strategy. In the majority of cases and institutions, the policy is consistent with the widely accepted international standards.

title: [Prevention of neonatal group B XXXX in Hungary in 2012. Preliminary data of a nation-wide survey].

answer: @entity3


abstract: BACKGROUND: The pandemic @entity3 (H1N1) 2009 [pdm (H1N1) 2009] spread through the world in 2009, producing a serious epidemic in Japan. Since it was suggested early that @entity2 is a risk factor for an increased severity of the @entity1 , the Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI) organized a working group for countermeasures, and investigated asthmatic @entity0 admitted to the hospitals for pdm (H1N1) 2009 @entity1 . METHODS: An appeal was made on the home page of the JSPACI to medical practitioners to input clinical information about asthmatic and non-asthmatic @entity0 (0-19 years) admitted to the hospital with pdm (H1N1) 2009 @entity1 . RESULTS: A total of 862 @entity0 (390 with @entity2 , and 472 without @entity2 ) from 61 medical centers were registered, and the data of 333 asthmatic @entity0 and 388 non-asthmatic @entity0 in all were entered in the analyses. The mean age was 7.4    2.9 years in the @entity2 group and 6.9    3.8 years in the non- @entity2 group. The percentage of @entity0 admitted for respiratory symptoms was significantly higher in the @entity2 group than in the non- @entity2 group (p < 0.001). There was no significant difference in the frequency of admission to the ICU or need for mechanical ventilation support between the two groups. No definite trend was detected in the relationship between the severity of @entity2 and the intensity of @entity2 attack. Antiviral drugs were administered within 24 hours in about 85% of the @entity0 in both groups. CONCLUSIONS: Asthma may not be a risk factor for severe pdm (H1N1) 2009 @entity1 in @entity0 .

title: Hospitalizations associated with pandemic @entity3 (H1N1) 2009 in asthmatic XXXX in Japan.

answer: @entity0


abstract: CASE REPORT: A 60-year-old female @entity0 underwent craniotomy for a @entity5 in the frontoparietal lobe. Histologically, it turned out to be a metastasis from an @entity6 . The @entity3 was found in the upper lobe of the left lung. The @entity0 had whole brain radiation therapy only, the @entity1 was not treated. 4 years later, she presented with @entity7 . A biopsy showed dilated sinuses filled with histiocytes, but no @entity3 cells. The diagnosis of sinus histiocytosis with massive @entity8 was made ( @entity9 ). Without any treatment, the @entity2 resolved completely a few weeks later. Similar episodes were observed several times in the following years. The @entity0 died more than 7 years after the diagnosis of a metastasizing @entity1 due to @entity4 . CONCLUSION: In a @entity0 with a @entity1 and suspected supraclavicular lymph node spread, Rosai-Dorfman's syndrome should be considered as a rare differential diagnosis.

title: XXXX and @entity9 . A clinicopathological study.

answer: @entity1


abstract: PURPOSE: @entity3 remains a common and morbid complication after complex aortic surgery. This study was performed to identify perioperative factors that contribute to @entity3 . METHODS: The perioperative outcomes of 183 @entity0 who underwent thoracoabdominal aortic surgery with supraceliac clamping were reviewed. During the interval from Jan. 1987 to Nov. 1996, thoracoabdominal @entity5 repair was performed in 154 @entity0 (type I, 49 @entity0 [27%]; type II, 21 @entity0 [11.5%]; type III, 55 @entity0 [30%]; type IV, 29 @entity0 [16%]), suprarenal @entity8 repair in 17 @entity0 (9%), and visceral/renal revascularization procedures in 12 @entity0 (6.5%). Intraoperative management included thoracoabdominal aortic exposure and clamp-and-sew technique with renal artery cold perfusion whenever the renal arteries were accessible (79% of cases). RESULTS: Relevant clinical features included preoperative @entity2 (85%), @entity1 (8%), single functioning kidney (10%), recent intravenous contrast injection (34%), @entity3 ( @entity7 level greater than 1.5 mg/dl; 24%), and emergent operation (19%). @entity6 , defined as both a doubling of serum @entity7 level and an absolute value greater than 3.0 mg/dl, occurred in 21 @entity0 (11.5%), of whom five required hemodialysis (2.7%). Variables associated with this complication included a preoperative @entity7 level greater than 1.5 mg/dl (p = 0.004) and a total cross-clamp time greater than 100 minutes (p = 0.035). The operative mortality risk (within 30 days; 8%) was significantly increased with @entity3 (odds ratio, 9.2; 95% confidence interval, 2.6 to 33; p < 0.005). CONCLUSIONS: @entity3 , although uncommon in contemporary practice, greatly increases the risk of @entity4 after thoracoabdominal aortic surgery. The overall incidence of @entity3 and dialysis requirement in the present series compare favorably with those reported using other operative techniques, specifically partial left heart bypass and distal aortic perfusion. These data suggest that @entity0 who have preoperative @entity3 are prone to @entity3 . Furthermore, regional hypothermic perfusion and minimal clamp times are important elements in the prevention of @entity3 after thoracoabdominal aortic surgery.

title: XXXX after thoracoabdominal aortic surgery.

answer: @entity3


abstract: UNASSIGNED: The @entity6 ( @entity6 ) family consists of 11 cytokines that play key regulatory roles in many immune and inflammatory processes. Anakinra (Kineret, Amgen, Inc.) is an @entity7 ( @entity7 ). Increased levels of @entity6 are found in several disease states suggesting that anakinra may be @entity1 associated with elevated @entity6 levels. Anakinra has been effectively used in the treatment of @entity3 juvenile idiopathic @entity4 and @entity9 ( @entity9 ). Despite its therapeutic benefits, anakinra also has potential side effects, including hepatotoxicity. We present a case of @entity9 in an adolescent male that was treated with anakinra. During treatment, the @entity0 developed @entity5 that resolved upon withdrawal of anakinra. Although anakinra-induced @entity2 has been reported in adults, including one case of subacute @entity8 , we believe our case is the first to show severe @entity5 in an adolescent treated with anakinra. This case provides significant insight into a potentially serious complication associated with anakinra. It is important to further delineate these complications as the treatment indications for this drug expand.

title: Anakinra-Induced @entity5 in an Adolescent XXXX with Still's Disease.

answer: @entity0


abstract: INTRODUCTION: @entity1 constitute a wide variety of disorders having high mortality and morbidity rates. Current protocols for management include surgical intervention, chemotherapy, and radiation which possess numerous adverse effects. Many phytochemicals are available with anticancer properties similar to anticancer drugs. Major benefit of these compounds is apparent lack of @entity3 to normal tissues. Graviola (botanical name: Annona Muricata) contain bioactive compound "annonaceous @entity6 " known for anticancer activity on @entity1 cell lines. AIMS: To determine @entity3 of Graviola and percentage cell inhibition at G2M phase of cell cycle. SETTINGS AND DESIGN: The @entity3 of aqueous extract of Graviola leaves on @entity4 ( @entity0 ) cell lines at various concentrations evaluated using @entity5 ( @entity2 ) assay. The percentage of @entity0 cell inhibition at G2M phase of cell cycle determined using flow cytometry. METHODS: Graviola Leaves, American Type Culture Collection @entity0 cell lines were procured from Skanda Laboratories, Bengaluru. The @entity3 of aqueous extract of Graviola on @entity0 cells at various concentrations evaluated using @entity2 assay. The percentage of @entity0 cell inhibition at G2M phase of cell cycle determined using flow cytometry. STATISTICAL ANALYSIS: Statistical analysis was done using one-way ANOVA. RESULTS: @entity2 assay showed statistically significant (P < 0.001) dose-dependent inhibition of @entity0 cell lines by Graviola with IC50 value of 12.42  g/ml. Flow cytometry revealed that Graviola at 25 and 50 g/ml arrested 53.39% and 52.09% cells in G2M phase of cell cycle respectively, which was statistically significant. CONCLUSION: Graviola showed significant cytotoxic activity and percentage of cell inhibition at G2M phase cell cycle against @entity0 cell lines.

title: Evaluation of @entity3 of aqueous extract of Graviola leaves on @entity4 cell-25 cell lines by XXXX assay and determination of percentage of cell inhibition at G2M phase of cell cycle by flow cytometry: An in vitro study.

answer: @entity5


abstract: Fifteen @entity0 , with a median age of 19  years having severe @entity7 (SAA) underwent human leucocyte antigen (HLA) identical sibling donor hematopoietic stem cell transplantation (HSCT) using conditioning regimens containing @entity4 with antithymocyte globulin (ATG) or a combination of @entity8 and @entity4 with or without ATG during December 2007 to May 2013. @entity2 and mini @entity5 were used as @entity6 ( @entity6 ) prophylaxis. Graft source included peripheral blood stem cells in 11, bone marrow in 3 and both in 1. One @entity0 had @entity1 while 14 @entity0 were engrafted with a median neutrophil and platelet engraftment time of 13.5  days. One @entity0 had secondary graft rejection. Acute @entity6 occurred in 3 @entity0 and chronic @entity6 in 4. One year death rate in engrafted @entity0 was 14.28  %. At a mean follow-up of 21.2  months, 12 (80  %) are alive and well. One of the donors was a @entity0 of @entity3 but the disease did not occur in the recipient. The graft was successful and the recipient is alive till date.

title: Improving Outcome of XXXX with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI).

answer: @entity7


abstract: OBJECTIVE: To investigate whether electrocochleography (ECochG) and @entity6 and @entity8 tests could predict progression from @entity3 ( @entity5 ). MATERIAL AND METHODS: ECochG and @entity6 and @entity8 tests were performed in 1569 @entity0 with various @entity2 , including definite @entity5 , atypical @entity5 , @entity10 , delayed endolymphatic @entity1 , @entity9 , cochleovestibulopathy and @entity7 . @entity0 with atypical @entity5 were divided into five categories based on their symptoms. RESULTS: A total of 115/118 @entity0 (97%) with definite @entity5 who underwent all 3 tests showed a positive result in at least 1 test. Ninety-nine @entity0 who did not satisfy the diagnostic criteria of definite @entity5 but had vertigo and/or @entity4 at the first visit subsequently progressed to definite @entity5 . It was retrospectively found that 92% of @entity0 showed at least 1 positive finding in these 3 tests at the initial stage. In those @entity0 who showed a negative test result in either ECochG or the @entity6 test, the possibility of progression to definite @entity5 was low. CONCLUSION: The combination of ECochG and the @entity6 and @entity8 tests was helpful in diagnosing endolymphatic @entity1 (ELH). ECochG and the @entity6 test were effective tools for predicting the progression to definite @entity5 in @entity0 with atypical @entity5 , @entity9 and other @entity2 . Our test results also indicated that the pathological state of atypical @entity5 included both non-ELH and ELH.

title: Prediction of progression from @entity3 using electrocochleography and XXXX and @entity8 tests.

answer: @entity6


abstract: OBJECTIVES: Mutations in the @entity12 subunit of the neuronal Na(+) /K(+) -ATPase are thought to be responsible for @entity7 , @entity8 , and other symptoms of @entity10 ( @entity10 ). However, the mechanisms through which @entity14 mutations mediate their pathophysiologic consequences are not yet understood. The following hypotheses were investigated: (1) Our novel knock-in @entity1 carrying the most common heterozygous mutation causing @entity10 ( @entity13 ) will exhibit the manifestations of the @entity0 condition and display predisposition to @entity7 ; and (2) the underlying pathophysiology in this @entity1 model involves @entity2 in response to electrical stimulation of Schaffer collaterals and abnormal predisposition to @entity5 ( @entity5 ). METHODS: We generated the @entity13 mutant @entity1 (Mashlool, Mashl(+/-) ) and compared mutant and wild-type (WT) littermates. Behavioral tests, amygdala kindling, @entity11 -induced @entity7 threshold, @entity7 ( @entity7 ), and other paroxysmal activities were compared between groups. In vitro electrophysiologic slice experiments on hippocampus were performed to assess predisposition to hyperexcitability and @entity5 . RESULTS: Mutant @entity1 manifested a distinctive phenotype similar to that of @entity0 with @entity10 . They had abnormal impulsivity, memory, gait, motor coordination, @entity6 , motor control, endogenous nociceptive response, paroxysmal @entity8 , @entity4 , @entity9 , and @entity7 , as well as predisposition to kindling, to @entity11 -induced @entity7 , and to sudden unexpected @entity3 . Hippocampal slices of mutants, in contrast to WT animals, showed hyperexcitable responses to 1  Hz pulse-trains of electrical stimuli delivered to the Schaffer collaterals and had significantly longer duration of K(+) -induced @entity5 responses. SIGNIFICANCE: Our model reproduces the major characteristics of @entity0 @entity10 , and indicates that @entity12 dysfunction results in abnormal short-term plasticity with @entity2 (potential mechanism for @entity7 ) and a predisposition to more severe @entity5 responses (potential mechanism for @entity8 ). This model of the @entity0 condition should help in understanding the molecular pathways underlying these phenotypes and may lead to identification of novel therapeutic strategies of @entity12 related disorders and @entity7 .

title: Knock-in @entity1 model of XXXX : Behavioral and electrophysiologic characterization.

answer: @entity10


abstract: OBJECTIVE: Analysis and evaluation of a multidisciplinary approach, postoperative results and survival of a group of @entity0 with resected @entity2 after a multimodal therapy. DESIGN: DESCRIPTIVE, prospective and observational study. @entity0 : Between January 2004 and December 2004, 124 @entity0 with @entity2 were evaluated. In 30 @entity0 pancreatic resection was performed, and they are the object of this study. Results of preoperative evaluation, postoperative morbidity and mortality, and long term survival were studied. RESULTS: Diagnostic evaluation was completed in ambulatory basis in 20% of the @entity0 . In 63% of cases, admission was done in the same day of surgery. In 3 @entity0 (9%), @entity1 resection was not achieved, therefore, concordance between radiological and surgical resectability rate was 91%. Resectability rate was 24.1%. Surgical Mortality was 3.3%, with a global morbidity rate of 56.6%. Survival at one, two, three and, four years was 76.2%, 56.3%, 43%, y 27.3% respectively. CONCLUSIONS: Technological development and coordination of efforts in multidisciplinary teams offer an accurate evaluation of @entity1 involvement, and may reduce the number of laparotomies without @entity1 resection. The application of a systematic and generalized multimodal treatment in @entity2 is progressively showing a tendency of progressive increase in resectability and survival rates in @entity2 .

title: Multidisciplinary approach and multimodal therapy in resected XXXX . Observational study.

answer: @entity2