abstract: @entity6 , a strong alpha-adrenergic receptor-stimulating agent, was compared with @entity4 in 65 @entity0 with out-of-hospital @entity2 , in a double-blind study. The resuscitation was performed by the physician-staffed Prehospital Emergency Care Unit of Helsinki University Central Hospital. The @entity0 received either 1.0 mg of @entity6 or 0.5 mg of @entity4 i.v. in the treatment of fine @entity5 , @entity2 or electromechanical dissociation. If two doses of either drug did not restore circulation, 0.5 mg of known 0.01% @entity4 was given i.v., maximally twice. In the @entity4 group, which consisted of 36 @entity0 with a mean age of 61 years, 10 @entity0 (28%) were successfully resuscitated. The @entity6 group consisted of 29 @entity0 with a mean age of 62 years. In this group nine @entity0 (31%) were successfully resuscitated. The two groups were comparable regarding their apnoea-times, and there was no difference in the need for extra @entity4 between the groups. No adverse effects, such as @entity1 or @entity3 , were noted in the @entity0 treated with either @entity4 or @entity6 , nor did the overall rate of successful resuscitation fall during the test period. It is concluded that @entity6 seems as effective as @entity4 in the treatment of @entity2 , but further studies seem warranted.

title: Comparison of XXXX and @entity6 in out-of-hospital cardiopulmonary resuscitation. A double-blind study.

answer: @entity4


abstract: OBJECTIVE: @entity0 with a history of @entity1 , postpartum @entity2 , or both are at high risk for postpartum relapse. The aim of this meta-analysis was to estimate the risk of postpartum relapse in these three @entity0 groups. METHOD: A systematic literature search was conducted in all public medical electronic databases, adhering to the PRISMA guidelines. Studies were included if they reported postpartum relapse in @entity0 diagnosed with @entity1 and/or a history of postpartum @entity2 or @entity1 according to DSM or @entity3 criteria or the Research Diagnostic Criteria. RESULTS: Thirty-seven articles describing 5,700 deliveries in 4,023 @entity0 were included in the quantitative analyses. The overall postpartum relapse risk was 35% (95% CI=29, 41). @entity0 with @entity1 were significantly less likely to experience severe episodes postpartum (17%, 95% CI=13, 21) than @entity0 with a history of postpartum @entity2 (29%, 95% @entity4 , 41). Insufficient information was available to determine relapse rates for @entity0 with @entity1 and a history of postpartum episodes. In @entity0 with @entity1 , postpartum relapse rates were significantly higher among those who were medication free during pregnancy (66%, 95% CI=57, 75) than those who used prophylactic medication (23%, 95% CI=14, 37). CONCLUSIONS: One-third of @entity0 at high risk experience a postpartum relapse. In @entity0 with @entity1 , continuation of prophylactic medication during pregnancy appears highly protective for maintaining mood stability postpartum. In @entity0 with a history of isolated postpartum @entity2 , initiation of prophylaxis immediately after delivery offers the opportunity to minimize the risk of relapse while avoiding in utero medication exposure.

title: Risk of Postpartum Relapse in XXXX and Postpartum Psychosis: A Systematic Review and Meta-Analysis.

answer: @entity1


abstract: OBJECTIVE: We aimed to determine the diagnostic yield of continuous monitoring with video electroencephalography (cVEEG) for pediatric inpatients with paroxysmal vital sign changes (PVSCs), and to identify risk factors for the PVSCs being @entity4 , based on clinical information available before cVEEG initiation. We hypothesized that PVSCs without @entity6 ( @entity6 ) were unlikely to be @entity4 , and also that @entity0 ' clinical characteristics would alter the risk of recording @entity4 . METHODS: We performed a single-center chart review of 324 cVEEG studies that were obtained for differential diagnosis of PVSCs. We examined the type of PVSCs that prompted cVEEG, associated @entity6 , and @entity0 characteristics, and whether the target events or @entity4 were recorded. We performed logistic regression analyses to determine which @entity0 and semiologic features altered the risk of the PVSCs being @entity4 , and which @entity0 characteristics altered the risk of recording any @entity4 . RESULTS: Target PVSCs were recorded in 52% (N = 169). @entity4 were recorded in 21% (N = 69) of the studies, often unrelated to the PVSCs (N = 39). When examining only PVSCs without @entity6 , only 4% (3/75) of studies obtained for @entity3 and 2.1% (1/48) of studies obtained for @entity1 desaturation revealed the target events to be @entity4 . No studies recorded ictal @entity2 (0/26), @entity5 (0/16), or @entity7 (0/18). In univariate analysis, there was a decreased risk that the events were @entity4 when PVSCs lacked @entity6 (odds ratio [OR] 0.23, 95% confidence interval [CI] 0.08-0.65). The risk was increased when the @entity0 had received an antiseizure medication (2.9, 1.3-6.5), the target PVSC was @entity3 (3.5, 1.5-8.5), and in particular, @entity3 with @entity6 (8.7, 3.7-20.8). In adjusted analyses, only @entity3 with associated @entity6 independently increased the risk of the PVSCs being @entity4 (7.7, 3.2-18.5). SIGNIFICANCE: PVSCs in the absence of @entity6 are rarely due to @entity4 . Ideally, cVEEG should be reserved for @entity0 with additional risk factors for @entity4 , beyond isolated PVSCs.

title: Diagnostic yield of continuous video electroencephalography for paroxysmal vital sign changes in pediatric XXXX .

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Bone demineralization is frequent in @entity6 formers with @entity8 . Although this pathologic link has been recognized for decades, the underlying mechanisms and risk factors associated with @entity7 / @entity2 in this population remain partially understood. DESIGN, SETTING, @entity0 , _ MEASUREMENTS: This study retrospectively analyzed determinants of low @entity1 ( @entity1 ) in 65 idiopathic @entity9 male @entity6 formers. Clinical and biologic evaluation included @entity1 measurement, bone-remodeling markers, analysis of @entity4 metabolism with oral @entity4 load test, and dietary inquiry. RESULTS: @entity0 with @entity7 (n=23, 35% of the population) presented significantly higher fasting calciuria as compared with normal bone density @entity0 (n=42) ( @entity4 / @entity5 ratio was 0.32 versus 0.24 mmol/mmol; P=0.006). Analysis of the whole population revealed a negative association between fasting @entity8 and @entity1 (P = 0.003), independent of confounding variables including body-mass index and @entity3 consumption. The fasting @entity4 / @entity5 ratio above 0.25 mmol/mmol was associated with a 3.8-fold increase in the risk of low @entity1 . CONCLUSION: In our study, fasting @entity8 after a 2-day @entity4 -restricted diet appears as the only biologic factor associated with low @entity1 , suggesting a bone- @entity4 efflux. Our results support the view of a parathyroid-independent pathologic process that remains to be identified. @entity9 @entity0 with low @entity1 do not excrete more @entity4 in 24-hour urine samples than @entity0 without low @entity1 .

title: @entity7 in male renal-stone-disease XXXX with idiopathic @entity8 .

answer: @entity0


abstract: AIM: To evaluate the risks of medical conditions, evaluate @entity5 , and assess @entity6 to treat @entity8 after @entity3 ( @entity3 ). METHODS: @entity3 is being performed more frequently worldwide as a treatment for medically-complicated @entity2 , and @entity8 is common post-operatively. We hypothesize that post-operative @entity8 is related to underlying medical conditions or narrowing of the @entity5 . This is a retrospective, single institution study of consecutive @entity0 who underwent sleeve gastrectomy from 2013 to 2015. @entity0 with previous bariatric procedures were excluded. Narrowing of a @entity5 includes: inability to pass a 9.6 mm gastroscope due to @entity7 or sharp angulation or spiral hindering its passage. RESULTS: Of 400 consecutive @entity0 , 352 are included; the prevalence of @entity8 is 22.7%; 33 @entity0 (9.3%) have narrowing of the sleeve with 25 (7.1%) having sharp angulation or a spiral while 8 (2.3%) have a @entity7 . All 33 @entity0 underwent balloon dilatation of the @entity5 and @entity8 resolved in 13 @entity0 (39%); 10 @entity0 (30%) noted resolution of @entity8 after two additional dilatations. In a multivariate model, medical conditions associated with post-operative @entity8 include @entity1 , symptoms of @entity4 , a low whole blood @entity11 level, @entity9 , use of non-steroidal anti-inflammatory drugs, and use of opioids. CONCLUSION: Narrowing of the @entity5 and @entity5 are common after @entity3 . @entity10 resolves @entity8 in 69% of @entity0 .

title: XXXX after @entity3 : Evaluation of risk factors and assessment of endoscopic intervention.

answer: @entity8


abstract: STUDY DESIGN: Prospective single-center study. OBJECTIVE: To analyze the efficacy and safety of a new technique of global vertebral correction with convex rod rotation performed on the @entity0 with @entity2 . SUMMARY OF BACKGROUND DATA: Surgical goal is to obtain an optimal curve correction in @entity3 surgery. There are various correction techniques. This report describes a new technique of global vertebral correction with convex rod rotation. MATERIALS AND METHODS: A total of 12 consecutive @entity0 with @entity1 @entity2 and managed by convex rod rotation technique between years 2012 and 2013 having more than 1 year follow-up were included. Mean age was 14.5 (range = 13-17 years) years at the time of operation. The hospital charts were reviewed for demographic data. Measurements of curve magnitude and balance were made on 36-inch standing anteroposterior and lateral radiographs taken before surgery and at most recent follow up to assess deformity correction, spinal balance, and complications related to the instrumentation. RESULTS: Preoperative coronal plane major curve of 62   (range = 50  -72  ) with flexibility of less than 30% was corrected to 11.5  (range = 10  -14  ) showing a 81% @entity3 correction at the final follow-up. Coronal imbalance was improved 72% at the most recent follow-up assessment. No complications were found. CONCLUSION: The new technique of global vertebral correction with Ucar's convex rod rotation is an effective technique. This method is a vertebral rotation procedure from convex side and it allows to put screws easily to the concave side.

title: A new corrective technique for XXXX (Ucar's convex rod rotation).

answer: @entity2


abstract: CASE DESCRIPTION: A 6-year-old Siberian Husky-mix @entity3 was examined for episodes of collapse. CLINICAL FINDINGS: Physical examination, echocardiography, abdominal ultrasonography, ECG, and thoracic computed tomography with contrast were performed and revealed a 2.5   2.3   2.0-cm mass over the pulmonic @entity5 , resulting in moderate @entity10 . Other abnormal findings included systemic @entity2 , @entity8 , @entity7 , and a urinary bladder mass. TREATMENT AND OUTCOME: Pulmonary arteriotomy was performed under @entity6 , and the mass was resected with transesophageal echocardiographic guidance and direct visualization. Results of histologic examination of the mass revealed @entity12 . Sequential follow-up examinations and telephone contacts (at 0.5, 5, and 15 months after surgery) revealed that the @entity0 had been free from episodes of collapse since surgery. No regrowth of the mass was noted on follow-up echocardiograms, and the @entity10 had resolved, although mild to moderate @entity4 later developed. The bladder mass was excised 15 months after the first surgery when @entity9 developed, and results of histologic examination of this mass revealed @entity12 . The @entity3 was eventually euthanized 31 months after the initial surgery for reasons that could not be directly linked to any recurrence of the pulmonary artery mass. CLINICAL RELEVANCE: @entity12 are @entity1 that can be located in various tissues, including large arteries. Computed tomography was helpful in predicting the resectability of the @entity13 in this @entity3 . Treatment with arteriotomy under @entity6 and mild @entity11 resulted in a favorable outcome.

title: Surgical treatment of a pulmonary artery vascular hamartoma in a XXXX .

answer: @entity3


abstract: @entity4 still remains a serious disease with significant morbidity and mortality. In @entity0 with known @entity1 , most cases are caused by oral viridans streptococci. These organisms are present in vast numbers on the gum margins and in gum pockets. They cause transient @entity2 during eating and tooth brushing. More substantial, but short-lived @entity2 can occur during dental treatment such as extraction and scaling. Bacteria may then become attached to abnormal endocardium leading to the development of @entity3 . Prophylaxis of @entity3 during dental procedures in @entity0 with known @entity1 should thus be aimed at reducing the number of bacteria entering the blood stream and eliminating those that get there. This can be sought first by good oro-dental hygiene and secondly by the use of prophylactic antibiotics. In this paper, we set out simple guidelines for practitioners in those countries that do not already have recommendations of their own. They are based on guidelines already in use in the United Kingdom, France, Switzerland and the United States.

title: Prophylaxis of XXXX for dental procedures. Report of a working party of the European Society of Cardiology.

answer: @entity3


abstract: PURPOSE: To evaluate which parameters of dynamic magnetic resonance (MR) imaging and T2 relaxation rate would result in optimal discrimination of @entity3 from normal peripheral zone (PZ) and central gland (CG) tissues and to correlate these parameters with @entity1 stage, Gleason score, @entity0 age, and @entity1 markers. MATERIALS AND METHODS: Of 58 @entity0 with @entity3 , 36 were included for analysis. @entity0 underwent MR imaging at 1.5 T with an endorectal-pelvic phased-array coil and subsequently underwent prostatectomy. A T2-weighted turbo spin-echo sequence, an intermediate-weighted sequence, and a fast T1-weighted gradient-echo sequence (seven sections in 2.03 seconds) during bolus injection of 0.1 mmol @entity5 per kilogram of body weight were performed. Contrast agent concentration-time curves were obtained for @entity3 and normal PZ and CG tissue by using whole-mount sections to guide placement of regions of interest. Onset time, time to peak, peak enhancement, relative peak enhancement, washout, and T2 relaxation rates were calculated. Multivariate receiver operating characteristic analysis was performed with and without relative peak enhancement. RESULTS: Results of multivariate receiver operating characteristic analysis showed that relative peak enhancement demonstrated the highest area under the receiver operating characteristic curve (AUC) in the PZ and the CG (AUC = 0.93, 0.82). Results of multivariate analysis without relative peak enhancement showed that relative peak enhancement in the PZ and washout in the CG demonstrated the highest AUC (AUC = 0.9, 0.81). Pearson correlation coefficients between the dynamic parameters or T2 relaxation rates in @entity2 and the @entity1 stage, Gleason score, @entity0 age, and @entity1 markers ranged between 0.02 and 0.44. CONCLUSION: The optimal parameter for discrimination of @entity3 in the PZ and CG was relative peak enhancement. If relative peak enhancement was not used, then peak enhancement was optimal in the PZ, and washout was optimal in the CG. Poor-to-moderate correlation was present between the dynamic parameters or T2 relaxation rate in @entity2 and the @entity1 stage, Gleason score, @entity0 age, @entity1 volume, and @entity4 .

title: XXXX from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging.

answer: @entity3


abstract: UNASSIGNED: @entity1 is a rare proliferative condition of the synovium that affects large joints. The primary treatment options are synovectomy and a combination of synovectomy and arthroplasty. We performed a systematic review of the literature, excluding all nonclinical and review articles with follow-up of less than 2 years. Primary outcomes reported were disease recurrence, symptom progression, and revision surgery. Student t tests were used to compare outcomes after synovectomy with outcomes after synovectomy combined with arthroplasty. Twenty-one studies (82 @entity0 ) were included. All represented level IV or V evidence. Fifty-one @entity0 (59.3%) were female. Mean (SD) age was 33.2 (12.6) years. Synovectomy alone was performed in 45 @entity0 (54.9%), and synovectomy with arthroplasty was performed in 37 @entity0 (45.1%). Mean (SD) follow-up was 8.4 (5.9) years. The groups' revision rates were not significantly different (26.2% vs 24.3%; P = .17). Mean (SD) time to revision was significantly (P = .02) longer in the synovectomy-with-arthroplasty group, 11.8 (4.5) years, than in the synovectomy-only group, 6.5 (3.9) years. Study results showed revisions are common after surgery for hip @entity1 , affecting 1 in 4 @entity0 regardless of which surgery they have-either synovectomy alone or synovectomy combined with arthroplasty. Revision is required sooner in synovectomy-only @entity0 than in @entity0 who also undergo arthroplasty.

title: XXXX of the Hip: A Systematic Review.

answer: @entity1


abstract: @entity4 and @entity2 neuroendocrine cells within the @entity5 ( @entity11 ) display mRNA expression for the @entity1 receptor subunits, @entity7 and @entity6 , @entity10 and @entity8 . The @entity6 subunit confers slow decay kinetics (relative to @entity7 / @entity9 receptors) and high @entity3 sensitivity to @entity1 receptor responses--properties which may contribute to the @entity1 receptor-mediated bursting manifested by these cells. Therefore, we examined @entity6 protein expression and its developmental profile in the @entity11 and compared it to that in the cortex and cerebellum--areas which have been studied previously. We performed Western blot analysis on @entity11 homogenates from embryonic, postnatal (PN7, 14, 21), and adult @entity0 using an @entity6 -specific antibody. Adult @entity6 levels in the @entity11 and PVN were similar but low relative to those of cortex. @entity11 @entity6 protein levels rose in the first postnatal week, remained high through PN21, and later declined to significantly lower levels in the adult. A similar profile was observed in cerebellum, where @entity6 expression displayed a sharp peak at PN14 and later declined to minimal or undetectable levels in the adult. In contrast, @entity6 continued to be overexpressed through adulthood in the cortex. The ontogenic pattern for @entity7 expression, which included unregulation during early postnatal life and adulthood, was similar in the @entity11 and cortex. A different pattern was observed for the cerebellum, where @entity7 levels increased gradually after ED17 to reach significantly greater adult levels. Of all three areas studied, the @entity11 displayed the earliest developmental rise in @entity7 levels. @entity11 explant cultures proved to be a useful preparation, since they contained neurons which synthesized @entity7 and @entity6 subunits in quantities similar to those of ED17 @entity11 . Our findings suggest that @entity1 receptors on @entity11 neuroendocrine cells are assembled using @entity7 and @entity6 subunits, and that their plastic expression in early postnatal life may play a role during development.

title: Developmental plasticity of @entity7 and XXXX subunit expression in the supraoptic nucleus of the @entity0 hypothalamus.

answer: @entity6


abstract: Mucosa-associated lymphoid tissue (MALT) @entity2 is a relatively common, indolent @entity5 . @entity3 with large @entity0 cells (LTCs) is believed to have the potential to transform to aggressive @entity5 ( @entity5 ) which may have a poor prognosis. @entity1 is a transcription factor. Its translocation and overexpression predicts an inferior prognosis and poor response to therapy in cases of @entity5 . In the current study, @entity1 expression was detected in @entity3 , and its relationship to the occurrence of LTCs, clinicopathological parameters and prognosis was assessed. A total of 69 cases were enrolled in the study, including 42 cases of @entity3 without LTCs, 20 cases of @entity3 with LTCs and 7 cases of @entity5 with a @entity3 component ( @entity5 +MALT). Immunohistochemistry and fluorescent in situ hybridization analyses were performed. In total, 15/42 (35.7%) cases were nuclear positive for @entity1 expression in the group without LTCs, whereas 15/20 (75.0%) and 4/7 (57.1%) cases were positive in the group with LTCs and in the group with @entity5 +MALT, respectively (P=0.004). Univariate and multivariate analysis were used to determine the correlations of @entity1 expression and clinicopathological parameters with @entity4 ( @entity4 ). @entity1 expression, Ann Arbor stage, LDH level and IPI were considerably associated with @entity4 according to the univariate analysis. However, only @entity1 expression >= 20% showed a statistical significance in the multivariate analysis (HR=20.604, 95% CI: 1.909-222.412, P=0.013). Therefore, @entity1 overexpression may play an important role in aggressive transformation and is an independent prognostic factor in @entity3 .

title: @entity1 overexpression predicts aggressive transformation and a poor outcome in mucosa-associated XXXX .

answer: @entity2


abstract: Highly differentiated sex chromosomes create a lethal imbalance in gene expression in one sex. To accommodate hemizygosity of the X chromosome in male @entity0 , expression of X-linked genes increases twofold. This is achieved by the @entity1 ( @entity1 ) complex, which modifies chromatin to increase expression. Mutations that disrupt the X localization of this complex decrease the expression of X-linked genes and reduce male survival. The mechanism that restricts the @entity1 complex to X chromatin is not understood. We recently reported that the siRNA pathway contributes to localization of the @entity1 complex, raising questions about the source of the siRNAs involved. The X-linked 1.688 g/cm(3) satellite related repeats (1.688(X) repeats) are restricted to the X chromosome and produce small RNA, making them an attractive candidate. We tested RNA from these repeats for a role in dosage compensation and found that ectopic expression of single-stranded RNAs from 1.688(X) repeats enhanced the male lethality of mutants with defective X recognition. In contrast, expression of double-stranded hairpin RNA from a 1.688(X) repeat generated abundant siRNA and dramatically increased male survival. Consistent with improved survival, X localization of the @entity1 complex was largely restored in these males. The striking distribution of 1.688(X) repeats, which are nearly exclusive to the X chromosome, suggests that these are cis-acting elements contributing to identification of X chromatin.

title: siRNAs from an X-linked satellite repeat promote X-chromosome recognition in XXXX .

answer: @entity0


abstract: OBJECTIVES: To present a model of decision and cost-effectiveness analysis that allows assessing the trade-off between the short-term risks of performing a carotid endarterectomy and the rate of preventable future events and the impact of real-world adherence of best medical treatment on cost-effectivenss of both therapeutic options. METHODS: We used data from current literature to define values for a base case and perform a sensitivity analysis. The primary endpoint was a comparison of the fatal and disabling @entity1 -free survival during a 5-year period in a cohort of hypothetical @entity0 who presented asymptomatic severe @entity2 and were treated with either prophylactic carotid endarterectomy or adherent and non-adherent best medical treatment, respectively. RESULTS: The difference in estimated fatal and disabling @entity1 -free survival favoring endarterectomy in @entity0 with asymptomatic severe @entity2 is 44 days over the course of 5 years in case of non-adherent best medical treatment. Over a 5-year time horizon, prophylactic @entity3 would be cost-effective in 50.8% of bootstrap replicates and non-persistent BMT might be economically dominant in 11.1%. The probability that @entity3 would be cost-effective at a willingness-to-pay threshold of @entity4 50 000/QALY gained was 71.8 %. In 17.9 % prophylactic @entity3 would be more costly and effective than persistent BMT, but its @entity5 was greater than the WTP, so persistent BMT would be optimal. CONCLUSIONS: In this model, in case of real-world drug adherence it was likely that a strategy of early endarterectomy might be a cost-effective or even the dominant therapeutic option in comparison with a strategy of medical therapy alone (deferred surgery). If background any-territory @entity1 rates on contemporary medical therapy would fall substantially below 0.7 per cent, surgery would cease to be cost-effective.   .

title: Impact of real-world adherence with best medical treatment on cost-effectiveness of carotid endarterectomy for asymptomatic XXXX .

answer: @entity2


abstract: Adequate indoor-air quality (IAQ)-defined by the temperature, relative humidity, and the levels of @entity0 , small particles, and total volatile organic compounds (TVOC)-is crucial in laboratory animal facilities. The ventilation standards for controlling these parameters are not well defined. This study assessed the effect of 2 ventilation strategies on IAQ in 2 rooms housing @entity1 ( @entity1 ). We hypothesized that using a demand-controlled ventilation ( @entity4 ) system with a baseline ventilation rate of less than 3 @entity3 ( @entity3 ) would maintain IAQ comparable to or better than the traditional constant flow rate (CFR) system at 12 fresh @entity3 . During a 60-d study period, each of the 2 rooms operated 30 d on @entity4 and 30 d on CFR ventilation. In both rooms, temperatures remained more consistently within the established setpoint during the @entity4 phase than during the CFR phase. Relative humidity did not differ significantly between rooms or strategies. @entity2 was lower during the CFR phase than @entity4 phase. Small-particle and TVOC levels were lower during CFR in the larger (3060 ft(3)) room but not the smaller (2340 ft(3)) room. During the @entity4 phase, the larger room was at the baseline airflow rate over 99% of the time and the smaller room over 96% of the time. The @entity4 strategy resulted in a baseline airflow rate of less than 3 @entity3 , which in turn provided acceptable IAQ over 96% of the time; higher ventilation rates were warranted only during sanitation periods.

title: Comparison of Indoor Air Quality between 2 Ventilation Strategies in a Facility Housing @entity1 ( XXXX ).

answer: @entity1


abstract: This review of @entity4 in @entity0 previously seen in a pediatric cardiology clinic attempts to identify factors that may have been predictive of @entity4 . The denominator for these factors is unknown. For example, the number of @entity0 with these possible risk factors who have well tolerated @entity3 is not known. Further studies are planned to document the incidence of these factors in @entity0 with similar lesions whom we continue to follow up. The following conclusions can be drawn from the study: More than three-quarters of the @entity0 who died suddenly had severe limitation of activity, @entity2 on chest radiograph or poor hemodynamic status at cardiac catheterization. The majority of @entity0 who died suddenly had an @entity3 in the 12 month period before death. A significant number of these @entity3 developed for the first time in the year before death. The presence of @entity3 was generally related to poor hemodynamic status in @entity0 who died suddenly. Most sudden @entity1 occurred with the @entity0 at rest and only approximately one-quarter occurred during participation in sports. Each cardiac diagnosis had its own specific profile of types of @entity3 Conspicuously absent from the list of diagnoses were @entity0 with a normal heart and @entity0 with @entity5 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity4 in a pediatric cardiology population, 1958 to 1983: relation to prior XXXX .

answer: @entity3


abstract: OBJECTIVE: To observe pressure changes in the spinal canal of the vertebrarium subjected to impact. From the point of view of impact, pressure changes and @entity1 , the relationship between the type of @entity0 and the severity of @entity1 were analyzed and some experimental data were provided for early evaluation of severity of @entity1 . METHODS: An experimental model of @entity0 was made with Type BIM-I bio-impact machine and techniques of high velocity vertical loading in static pattern and stress shielding were adopted. Vertebral sections T10-L4 taken from fresh cadavers were impacted and pressure changes in the spinal canal were observed. The types and severity of @entity0 were studied with gross and radiography examination. RESULTS: Great positive pressure wave (wave A) in the spinal canal of the 4 vertebral specimens with @entity0 was recorded. The peak value of pressure was correlated with the severity of posterior column injuries. Generally, the peak value of pressure was low in the samples with posterior column injuries, but high in the samples without injuries. The predominant features of @entity0 were @entity0 and severe destruction of the skeletal and fiber structure of the spinal canal. Positive and negative pressure waves (wave B) were recorded in 2 vertebral samples in which no significant abnormal changes were found by radiography examination, however, a little liquid effusion in the vertebral body was found by gross examination. CONCLUSIONS: The type of pressure wave in the spinal canal is related to the deformation or the destruction of the spinal canal structure. The peak value of the pressure is non-linearly related to the obstruction in the spinal canal, but related to posterior column injuries.

title: Pressure changes in spinal canal and evaluation of XXXX in spinal section subjected to impact.

answer: @entity1


abstract: BACKGROUND: @entity5 caused by @entity7 is associated with the development and exacerbation of childhood @entity3 . Little is known about the effects of respiratory @entity7 in the absence of illness. Using quantitative PCR (qPCR) for common respiratory viruses and for two genes known to be highly upregulated in @entity7 ( @entity8 / @entity2 ), we screened 92 asthmatic and 69 healthy @entity0 without illness for @entity6 . RESULTS: We found 21 viral qPCR-positive and 2 suspected @entity4 subjects with high expression of @entity8 / @entity2 . We applied a dual RNA-seq workflow to these subjects, together with 25 viral qPCR-negative subjects, to compare qPCR with sequencing-based virus detection and to generate the airway transcriptome for analysis. RNA-seq virus detection achieved 86% sensitivity when compared to qPCR-based screening. We detected additional respiratory viruses in the two @entity8 / @entity2 -high subjects and in two of the qPCR-negative subjects. Viral read counts varied widely and were used to stratify subjects into Virus-High and Virus-Low groups. Examination of the host airway transcriptome found that the Virus-High group was characterized by immune cell airway infiltration, downregulation of cilia genes, and dampening of type 2 @entity1 . Even the Virus-Low group was differentiated from the No-Virus group by 100 genes, some involved in @entity9 signaling. CONCLUSIONS: @entity6 without illness is not innocuous but may determine the airway function of these subjects by driving immune cell airway infiltration, cellular remodeling, and alteration of asthmogenic gene expression.

title: Dual RNA-seq reveals @entity7 in asthmatic XXXX without @entity5 which are associated with changes in the airway transcriptome.

answer: @entity0


abstract: AIM: To compare the pregnancy outcome, in particular gestational age and birth weight in @entity0 with @entity4 ( @entity4 ) diagnosed before and after pregnancy, and to review data on presence or absence of the antiphospholipid (aPL) antibody and flares of disease activity. METHOD: Case histories were reviewed of @entity0 with a diagnosis of @entity4 and an obstetric event attending Monash Medical Centre (MMC) over an eight year period (1988-96). Fifty-four pregnancies in 28 @entity0 were studied, with 44 occurring after the diagnosis of @entity4 (Group 1) and ten prior to the diagnosis of @entity4 (Group 2). RESULTS: In Group 1 there were 25 live births (63%) with 16 full term and nine premature deliveries, 12 @entity5 , three foetal deaths in utero and four elective terminations. In Group 2 there were seven live births (70%), two @entity5 and one @entity2 in utero. The mean gestational age of live births was 35.8 weeks and 39.2 weeks respectively (p < 0.001). The mean birth weight of live births was 2448 g and 3030 g respectively (p < 0.023). a PL antibodies were positive in eight of 26 @entity0 tested with three live births and were negative in 18 of 26 @entity0 with 12 live births. Flares of disease activity occurred in 17 of 28 pregnancies. CONCLUSION: Pregnancy in @entity0 with a predisposition to @entity4 have a high risk of an adverse outcome. @entity3 confers an additional risk. The mean gestational age and birth weight were significantly less in @entity0 with @entity1 . Mild flares in disease activity resulted in a favourable outcome while renal flares had a worse outcome.

title: Pregnancy outcome in @entity4 ( XXXX ): a review of 54 cases.

answer: @entity4


abstract: To determine whether choice of material used for patch closure following @entity4 ( @entity4 ) influences rates of early or late restenosis, @entity1 , and @entity2 , 274 consecutive CAEs were retrospectively reviewed. Saphenous vein (SV) was used in 159 (58.0%) procedures; everted, double-thickness jugular vein (JV) was used in 25 (9.1%); and knitted Dacron (KD) was used in 90 (32.9%). Primary closure was not used in this series. There were four perioperative @entity1 : two (1.3%) in SV, one (4%) in JV, and one (1.1%) in KD ( @entity5 ). Follow-up was obtained on 263 (96%) operated arteries (mean 41.5 months). Duplex scan results were available for 236 (89.7%) of these arteries (mean follow-up time 33.7 months). There were three (2%) late @entity1 in SV and two (2.2%) in KD ( @entity5 ). In long-term follow-up, one @entity0 (0.7%) in SV and two (2.4%) in KD developed > 80% @entity3 ( @entity5 ). One @entity0 (0.7%) in SV, one (5.3%) in JV, and one (1.2%) in KD had total occlusion of the operated vessel ( @entity5 ). Three procedures (2.2%) in SV, 1 (5.3%) in JV, and 7 (8.5%) in KD demonstrated moderate @entity3 (50-79%) ( @entity5 ). Three-year follow-up shows that choice of patch material does not affect early or late @entity1 rate, @entity1 -related @entity2 rate, rate of high-grade (> 80%) restenosis, or rate of total occlusion. There is a higher incidence of moderate @entity3 in KD. Although our results and a review of the literature do not indicate that these @entity0 are at increased risk for symptoms or progression of @entity3 , they should be followed by duplex scanning to ensure that this is the case.

title: Long-term follow-up of saphenous vein, internal jugular vein, and knitted Dacron patches for XXXX .

answer: @entity4


abstract: BACKGROUND: The usefulness of @entity1 therapy for @entity3 has not yet been fully clarified. METHODS: Of 40 @entity0 diagnosed with @entity3 , twenty @entity0 complicated by @entity4 but normal cardiac function (left ventricular ejection fraction > or = 50%) were divided retrospectively into one group (n = 7) receiving @entity2 and another (n = 13) not receiving these agents. Over a mean observation period of 79.4 +/- 39.9 months, long-term outcome and laboratory findings were compared between the two groups and side effects also were noted. RESULTS: There were no deaths in the @entity1 -treated group. In the untreated group, 2 @entity0 died (15.4%). @entity4 resolved in 4 of the 7 @entity0 in the treated group (57.1%), but did not resolve or improve in any of the untreated @entity0 (p < 0.05). Left ventricular ejection fraction did not differ significantly between the treated and untreated groups at the time of initial evaluation (66.7 +/- 6.5% vs. 60.5 +/- 6.4%). In the follow-up period, a marked decline in the ejection fraction had occurred in the untreated group (37.6 +/- 17.3%), but not in the treated group (62.1 +/- 4.4%; p < 0.005). @entity5 was not present at the initial assessment in any @entity0 in either group. In the follow-up period, @entity5 occurred in only 1 of 7 treated @entity0 (14.3%), but was present in 8 of 13 untreated @entity0 (61.5%; p < 0.05). However, side effects of @entity1 therapy were noted in 6 of the 7 treated @entity0 (85.7%). CONCLUSION: Our findings suggest that @entity2 are useful in the treatment of @entity3 complicated by @entity4 but with normal cardiac function. However, these agents must be used with caution, with the maintenance dose kept as low as possible.

title: Efficacy of @entity2 in sarcoidosis presenting with XXXX .

answer: @entity4


abstract: BACKGROUND: @entity6 is a common cause of adult acquired @entity0 . The cause of @entity6 is often multifactorial and may include @entity5 , poor blood supply to the tendon, and, rarely, @entity2 . CASE DESCRIPTION: We present the case of a 69-year-old male with @entity6 secondary to a @entity1 that occurred directly into the posterior tibial tendon. This injury led to an acquired adult @entity0 that ultimately required surgical reconstruction. At the time of surgery, the posterior tibial tendon was severely degenerative at the site of skin penetration. LITERATURE REVIEW: Previous case reports of @entity1 describe full-thickness skin penetration with a subsequent inflammatory response and large zone of @entity7 . This is the first reported case of stingray @entity1 and @entity4 directly into tendon with subsequent @entity3 . CLINICAL RELEVANCE: There are thousands of stingray injuries in the United States annually. Injuries vary in severity depending on the type of stingray, size of stingray, and depth and location of injury. For certain injuries, such as direct penetration into tendon, early irrigation and debridement may limit subsequent deficits caused by progressive @entity3 . LEVELS OF EVIDENCE: Therapeutic, Level IV: Case study.

title: Unique Case of Posterior Tibial XXXX After Stingray Strike.

answer: @entity3


abstract: BACKGROUND: We retrospectively evaluated the results of surgical treatment for anterior abdominal wall - @entity1 . METHODS: Records for 13 @entity0 operated on for @entity1 from 1997-2013 were searched for age, gender, abdominal/pelvic surgical history, pregnancy, @entity2 , pre-operative radiological examinations, @entity1 size, multifocality, surgical procedure, @entity1 presence at surgical margins, recurrence, morbidity, and mortality. Local recurrence-free survival probabilities were estimated by the Kaplan-Meier method and stratified by various clinicopathological variables. RESULTS: There were 11 female (84,6%) and 2 male (15,4%) @entity0 with a median age of 36 years. Seven (53,8%) - @entity0 had previous abdominal/pelvic surgery, five (38,5%) had a history of pregnancy, and one (7,6%) had @entity2 . Two (15,3%) @entity0 had multifocality on their pre-operative radiological examinations. Mean @entity1 -diameter was 4,6 cm (SD 3,2 cm ; range 2-12 cm). After the excision of the masses in five (38,5%) @entity0 , synthetic materials were used to close the abdominal wall defects. Two (15,3%) @entity0 with positive surgical margins after -surgery were re-operated. Three (23%) @entity0 required a second surgical intervention after the mass excisions were performed. Mean follow-up time was 56,7 months. Recurrence was observed in three @entity0 during follow-up. Increased @entity1 size, history of previous abdominal/pelvic surgery, and the presence of multifocality had a negative effect on local recurrence-free survival. There was no mortality during follow-up. CONCLUSIONS: @entity1 are characterized by high recurrence, even after proper surgical excisions. Preoperative differential diagnoses of these @entity1 should be done and a post-operative follow-up protocol should be followed.

title: Results of surgical treatment of anterior XXXX : 13 cases reviewed with literature.

answer: @entity1


abstract: CONTEXT: In majority of couples experiencing recurrent @entity1 (RPL), etiology is still unknown. Two genetic factors have been suggested to underlie @entity3 in a subset of @entity0 , namely skewed X chromosome inactivation in females and Y chromosome microdeletions in their partners. In males, microdeletions of the Y chromosome are known to cause spermatogenetic failure and @entity5 . AIMS: The aim of the study was to find out the role of Y chromosome microdeletion in male partners of couples experiencing RPL. SETTINGS AND DESIGN: University hospital and genetic laboratory. Prospective case-control study. SUBJECTS AND METHODS: 59 couples with a history of RPL and 20 fertile controls (FC) with no @entity3 were included in the study. The study subjects were divided into male partners of RPL couples with @entity2 ( @entity2 ) (n = 8), and couples with normal semen parameters (NS) (n = 51). Fertile controls with normal semen parameters were (FC) (n = 20). Y chromosome microdeletion was performed on 40 male partners of RPL and 20 FC. STATISTICAL ANALYSIS USED: Chi-square test. P <0.05 were considered statistically significant. RESULTS: 13 of the 40 RPL cases showed deletion in three @entity4 factor loci on the long arm of Y chromosome. The P value was significant with Y chromosome microdeletion in RPL cases as compared to 20 FC where no Y chromosome microdeletion was present. CONCLUSIONS: Y chromosome microdeletion may be an important hidden cause of recurrent pregnancy @entity3 and can be offered to couples with the undiagnosed cause of @entity3 .

title: Microdeletion of Y chromosome as a cause of recurrent XXXX .

answer: @entity1


abstract: BACKGROUND: @entity5 ( @entity6 ) is an immunomodulatory drug, and its use in @entity1 has previously been reported. The aim of this study was to review the Leeds Colitis Clinic experience of the safety and efficacy of @entity6 in treating @entity0 with refractory @entity2 ( @entity2 ) and @entity3 ( @entity3 ). This is an extension of a previously published study from our center with a longer follow-up period and approximately twice the number of @entity0 . METHODS: A retrospective analysis was performed of the records of all @entity0 treated with @entity6 for @entity1 over a 5-year period. RESULTS: Of 70 @entity0 identified, 67 had previously been treated with @entity4 unsuccessfully. Seventeen of the 70 @entity0 had been successfully maintained in remission with @entity6 for an average duration of 33 months. Treatment with @entity6 was discontinued for 53 @entity0 , 17 because of side effects and 36 because they had not responded to the treatment. CONCLUSIONS: In our series, 17 @entity0 (24.3%) had a sustained steroid-free remission with @entity6 therapy. Nineteen @entity0 (27%) experienced side effects, of which 17 (24.3% of the total group) had to discontinue therapy. An additional 36 (51.4%) required an escalation in medical therapy or surgery because of failure of the @entity6 therapy. @entity6 may have a role in the treatment of refractory @entity1 , especially in @entity0 who have previously failed standard therapies such as @entity4 .

title: Mycophenolate mofetil therapy for refractory XXXX .

answer: @entity1


abstract: BACKGROUND: Most @entity0 with @entity5 treat @entity1 episodes with over-the-counter medication. Combination analgesics containing @entity6 may be more effective and as well tolerated as monotherapy. The aim of this study was to evaluate the efficacy of the combination of @entity2 , @entity4 ( @entity4 ) and @entity6 in @entity5 using recently recommended endpoints. METHODS: Four randomized, controlled trials of identical design in 1,900 @entity0 with @entity5 comparing @entity2 , @entity4 and @entity6 vs. @entity4 or placebo were pooled. Analysis populations were 'all @entity1 episodes' and those with 'severe @entity3 at baseline'. Post-hoc defined primary endpoint: @entity1 episodes @entity3 -free at 2  h. Secondary endpoints: @entity1 episodes @entity3 -free at 1  h, @entity1 response at 2  h (mild or no @entity3 ), degree of interference with daily activities. RESULTS: 6,861 @entity1 episodes were treated, including 2,215 severe @entity1 episodes. The proportion of @entity1 episodes @entity3 -free at 2  h was significantly higher with the triple combination (28.5%) vs. @entity4 (21.0%) and placebo (18.0%) (p   <   0.0001), and similarly for those severe at baseline (20.2% vs. 12.1% and 10.8%; p    <=   0.0003). A similar pattern of superiority was observed for secondary endpoints. The triple combination was generally well tolerated. CONCLUSIONS: The combination of @entity2 , @entity4 and @entity6 is effective and well tolerated in @entity5 , and significantly superior to @entity4 with regard to being @entity3 -free at 2  h, @entity1 response at 2  h and ability to return to daily activities, even in those with @entity3 rated severe at baseline.

title: Use of a fixed combination of @entity2 , @entity4 and @entity6 compared with @entity4 alone in XXXX : meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies.

answer: @entity5


abstract: This speculative paper concerns certain fundamentals of healing and psychotherapy which we mistakenly tend to take for granted. I discuss our need for the feeling of harmony, @entity1 , and oneness. I call this archetypal need our 'normal autistic expectation'. When met, we experience well-being and 'healing'. If not sufficiently and reliably met, this expectation becomes an omnipotent demand ('autistic demand'). Frustration then brings about angry destructiveness, either outwardly directed or inwardly directed, with bodily changes which must be processed if bodily damage is to be minimized. Bereavement, the loss of a @entity0 necessary for one's feeling of @entity1 (a 'self-object'), is an extreme and well-researched example of such damage. Our selfobjects are 'healing' when they help us to complete our sense of self. Our @entity0 -, our profession, our colleagues, our place of work and our financial security are normally all part of our self-object structure. I give examples where @entity0 ' own needs for survival or intactness mean that they have to externalize their own hurt and anger for long periods of their therapy. This often means that the therapist's own @entity1 and health are under attack, and even damaged permanently, or at least until the damage can be processed. The nature of 'processing' in this sense is therefore in need of energetic research.

title: Possible psychosomatic hazards to the therapist: XXXX as self-objects.

answer: @entity0


abstract: BACKGROUND: @entity3 are one of the most important prognostic factors in @entity5 ( @entity5 ). However, only a limited number of @entity0 have such informative @entity3 . The prognostic value of immunophenotyping in this disease is still unclear. METHODS: Seven hundred and eighty-three newly diagnosed @entity5 @entity0 treated in the German SHG- @entity5 trials in 1991 and 1996 were analyzed with a panel of 33 antibodies. Expression was correlated to overall survival, complete remission-rate, and complete remission duration, and tested in a multivariate analysis including other clinical and biological markers. RESULTS: With a median follow-up of 4.3 years, @entity0 with @entity5 blasts negative for @entity9 , @entity10 , @entity12 , @entity4 , and @entity2 , or positive for @entity8 , @entity1 , @entity6 , @entity11 , and @entity7 had superior overall survival. This effect was associated with a significantly higher complete remission rate ( @entity12 , @entity4 , @entity2 , and @entity11 ) or a longer complete remission duration ( @entity9 , @entity10 , and @entity11 ). Cox-regression analysis, including cytogenetic, morphologic, and biologic parameters showed @entity9 , @entity12 , @entity4 , and @entity11 as independent factors for overall survival. These markers were used for a prognostic score. @entity0 were pooled in three groups with highly significant differences of overall survival. The prognostic relevance of this score was confirmed in @entity0 with normal karyotype and/or in younger @entity0 </= 60 years. CONCLUSIONS: Immunophenotyping is not only helpful for diagnosis but is of independent significance for prognosis, and may be useful for risk stratification in @entity5 @entity0 .

title: Immunophenotyping is an independent factor for risk stratification in XXXX .

answer: @entity5


abstract: BACKGROUND: Ultraviolet radiation is thought to play a causative role in various @entity4 such as @entity3 , @entity0 , and possibly @entity2 . Since most of the energy is absorbed by pigmented cells, the aim of this study was to examine and compare the reactions of different ocular melanocytic cells to ultraviolet light in vitro. MATERIALS AND METHODS: @entity1 iris melanocytes, choroidal melanocytes, iris pigment epithelial cells, and retinal pigment epithelial cells were isolated and cultured. Semiconfluent cultures were exposed to ultraviolet radiation (280-380 nm). Cell number and melanin content were measured 10 days after radiation. Selected samples were examined by transmission electron microscopy. RESULTS: Following irradiation with ultraviolet light for 30 s, 60 s, and 120 s, the number of cells in culture decreased markedly. In contrast, total melanin content in the cultures of iris melanocytes, choroidal melanocytes, and iris pigment epithelial cells did not decrease despite the reduced number of cells. This finding suggested an increase in melanin per cell. However, the increase in average melanin content observed was not due to melanogenesis, because treatment with the melanogenesis inhibitor @entity5 did not reduce the melanin content of the cultures and electron-microscopic examination showed no morphological evidence of increased melanogenesis. CONCLUSION: In vitro, there was no convincing evidence of ultraviolet radiation-induced melanogenesis in ocular pigmented cells. Thus, it seems that ultraviolet radiation is a selection factor: more densely pigmented cells survive the treatment better than less pigmented cells.

title: Effect of ultraviolet radiation on melanogenesis in four different types of cultured XXXX ocular pigmented cells.

answer: @entity1


abstract: PURPOSE: There is limited literature on nonoperative treatment of open type I @entity6 fractures. Our purpose was to evaluate the rate of @entity2 in @entity6 @entity0 with @entity5 treated nonoperatively at our institution without admission from the @entity3  ( @entity3 ). METHODS: We performed a retrospective chart review of all @entity0 who sustained a type I open @entity1 of the forearm or tibia from 2000 through 2013. Forty @entity0 fit the inclusion criteria: <18  years old with type I open @entity1 treated nonoperatively with irrigation and debridement, followed by closed reduction and casting of the @entity1 under conscious sedation in the @entity3 . All @entity0 were discharged home. The primary outcome was presence of @entity2 . Secondary outcomes included occurrence of a delayed union, time to union, complications, and residual angulation. RESULTS: There were no reported or documented infections. There was one case of a retained foreign body (<1  cm) in a mid-diaphyseal forearm @entity1 , which was removed in clinic at 4  weeks after the @entity0 developed a @entity4 with no infectious sequela. There was one case of a delayed union; all @entity0 eventually had complete bony union. There was minimal residual angulation in both upper and lower extremities at last follow-up. CONCLUSIONS: Nonoperative treatment of @entity5 in @entity6 @entity0 can be performed safely with little risk of @entity2 . This preliminary evidence may serve as a foundation for future prospective studies.

title: Is nonoperative treatment of XXXX @entity5 safe and effective?

answer: @entity6


abstract: BACKGROUND: @entity6 , @entity3 and @entity5 are associated with increased risk of @entity4 . However, little is known about the underlying signaling events influencing risk. We aimed to investigate the relationship between these risk factors and @entity7 phosphorylation, to determine prognostic value. METHOD: VEGF-positive @entity4 biopsies, with known HPV status, were analyzed by immunohistochemistry (IHC) for @entity7 , phosphorylated at residues S473 and T308. Comparisons between the tissues were carried out using a Mann-Whitney U test. Associations between the variables and continuous immunohistochemical parameters were evaluated with general linear models. @entity0 characteristics and pAkt IHC score were analyzed for possible association with overall survival by Cox proportional hazard models. RESULTS: Immunohistochemistry revealed that @entity1 @entity0 had significantly higher levels of pAkt T308 than S473 (P   <   0.001). Smoking and @entity3 were found to be independent risk factors for @entity7 phosphorylation at T308 (P   =   0.022 and 0.027, respectively). @entity0 with @entity1 positive for HPV or pAkt S473 had a poorer prognosis (P   =   0.005, and 0.004, respectively). @entity0 who were heavy drinkers were 49 times more likely to die than non-drinkers (P   =   0.003). @entity0 with low pAkt T308 were more likely to be HPV positive (P   =   0.028). Non-drinkers were also found to have lower levels of pAkt T308 and were more likely to have @entity1 positive for HPV than heavy drinkers (P   =   0.044 and 0.007, respectively). CONCLUSION: This study suggests different mechanisms of @entity2 are initiated by smoking, @entity3 and HPV. Our data propose higher phosphorylation of @entity7 at T308 as a reliable biomarker for smoking and @entity3 induced @entity4 progression and higher phosphorylation of @entity7 at S473 as a prognostic factor for @entity4 .

title: Activation of @entity7 at T308 and S473 in XXXX , @entity6 and HPV-induced @entity4 : is there evidence to support a prognostic or diagnostic role?

answer: @entity3


abstract: The main strategy used for the detection of circulating @entity1 cells (CTC) and micrometastases in solid @entity1 is the polymerase chain reaction (PCR) amplification of tissue specific messenger RNA present in the @entity1 cells. PCR was more sensitive than conventional techniques, allowing the identification of one @entity1 cell diluted into 1 mL of blood. PCR was shown to be specific in most studies related to the detection of CTC and marrow micrometastases in @entity3 and @entity2 ( @entity2 ). PCR positivity for thyroid markers was reported in the blood of control subjects. Large variations in the PCR positivity rates and the prognostic value of these assays have been encountered in @entity2 and @entity3 . There was a correlation between PCR and stage in some but not all the studies. Despite these discrepancies, many investigators have shown PCR to be predictive of outcome in @entity2 and especially in @entity3 . PCR in blood and bone marrow was an independent predictor of overall and disease-free survival in @entity3 @entity0 rendered surgically free of disease. These tests may help better stratify @entity0 for radical surgeries and adjuvant therapy. Large prospective and interlaboratory studies are needed to confirm the accuracy and prognostic value of these assays.

title: Review: polymerase chain reaction detection of micrometastases and circulating @entity1 cells: application to XXXX , prostate, and thyroid carcinomas.

answer: @entity3


abstract: BACKGROUND: The relationship between changes in endocardial cushion and resultant @entity1 ( @entity1 ) has yet to be established. It has been shown that increased regurgitant flow early in embryonic heart development leads to @entity4 , but it remains unclear how abnormal endocardial cushions during the looping stages might affect the fully septated heart. The goal of this study was to reproducibly alter blood flow in vivo and then quantify the resultant effects on morphology of endocardial cushions in the looping heart and on CHDs in the septated heart. METHODS: Optical pacing was applied to create regurgitant flow in @entity1 , and optical coherence tomography (OCT) was utilized to quantify regurgitation and morphology. Embryonic quail hearts were optically paced at 3 Hz (180 bpm, well above intrinsic rate 60-110 bpm) at stage 13 of development (3-4 weeks @entity0 ) for 5 min. Pacing fatigued the heart and led to at least 1 h of increased regurgitant flow. Resultant morphological changes were quantified with OCT imaging at stage 19 (cardiac looping-4-5 weeks @entity0 ) or stage 35 (4 chambered heart-8 weeks @entity0 ). RESULTS: All paced embryos imaged at stage 19 displayed structural changes in cardiac cushions. The amount of regurgitant flow immediately after pacing was inversely correlated with cardiac cushion size 24-h post pacing (P value   <   .01). The embryos with the most regurgitant flow and smallest cushions after pacing had a decreased survival rate at 8 days (P < .05), indicating that those most severe @entity4 were lethal. Of the embryos that survived to stage 35, 17/18 exhibited CHDs including @entity2 , @entity3 , hypoplastic ventricles, and common AV canal. CONCLUSION: The data illustrate a strong inverse relationship in which regurgitant flow precedes abnormal and smaller cardiac cushions, resulting in the development of CHDs.

title: Increased regurgitant flow causes @entity4 in an avian embryonic model of XXXX .

answer: @entity1


abstract: BACKGROUND: Harm reduction is an evidence-based, effective response to @entity3 transmission and other harms faced by @entity0 who inject drugs, and is explicitly supported by the Global Fund to Fight @entity4 , @entity2 and @entity1 . In spite of this, @entity0 who inject drugs continue to have poor and inequitable access to these services and face widespread stigma and discrimination. In 2013, the Global Fund launched a new funding model-signalling the end of the previous rounds-based model that had operated since its founding in 2002. This study updates previous analyses to assess Global Fund investments in harm reduction interventions for the duration of the rounds-based model, from 2002 to 2014. METHODS: Global Fund @entity3 and @entity5 / @entity3 grant documents from 2002 to 2014 were reviewed to identify grants that contained activities for @entity0 who inject drugs. Data were collected from detailed grant budgets, and relevant budget lines were recorded and analysed to determine the resources allocated to different interventions that were specifically targeted at @entity0 who inject drugs. RESULTS: 151 grants for 58 countries, plus one regional proposal, contained activities targeting @entity0 who inject drugs-for a total investment of @entity6  620million. Two-thirds of this budgeted amount was for interventions in the "comprehensive package" defined by the United Nations. 91% of the identified amount was for Eastern Europe and Asia. CONCLUSION: This study represents an updated, comprehensive assessment of Global Fund investments in harm reduction from its founding (2002) until the start of the new funding model (2014). It also highlights the overall shortfall of harm reduction funding, with the estimated global need being @entity6  2.3billion for harm reduction in 2015 alone. Using this baseline, the Global Fund must carefully monitor its new funding model and ensure that investments in harm reduction are maintained or scaled-up. There are widespread concerns regarding the withdrawal from middle-income countries where harm reduction remains essential and unfunded through other sources: for example, 15% of the identified investments were for countries which are now ineligible for Global Fund support.

title: The Global Fund to Fight XXXX , @entity2 and @entity1 's investments in harm reduction through the rounds-based funding model (2002-2014).

answer: @entity4


abstract: INTRODUCTION/PURPOSE: To evaluate differences in sedentary time and compare levels of physical activity and sedentary behavior to the Australian physical activity recommendations between toddlers with @entity1 ( @entity1 ) according to functional capacity (Gross Motor Function Classification System [GMFCS]) and age-matched @entity0 with typical development (CTD). METHODS: @entity0 (2.4    0.5 yr old) were split into CTD (n = 20), GMFCS I-II (n = 32), GMFCS III (n = 14), and GMFCS IV-V (n = 12) groups and wore a triaxial ActiGraph   for 3 d. Validated cut points were applied to identify sedentary and active time and the number and duration of sedentary bouts and breaks for each group. Analysis of variance (ANOVA) with post hoc testing, chi-square analysis, and the Fisher exact test were used to compare groups. RESULTS: No difference between the CTD group (49%) and GMFCS I-II group (52%) was found for sedentary time as a percentage of wear time. The GMFCS III group was more sedentary than both these groups (62%, P < 0.05). The GMFCS IV-V group was more sedentary than all the other groups (74%, P < 0.05). The CTD group and GMFCS I-II group was more likely to spend 180 min or longer in active play on all 3 d than the GMFCS IV-V group (P < 0.05). The GMFCS IV-V group was more likely to have sedentary bouts >= 60 min or longer than all other groups (P < 0.05). CONCLUSION: Differences in sedentary behavior between the CTD and mildly impaired @entity0 with @entity1 (GMFCS I-II) are not evident in the toddler years. @entity0 with moderate-to-severe functional impairment are progressively more sedentary and less likely to meet physical activity guidelines. Further research into the health implications of high levels of sedentary behavior in toddlers is required.

title: Sedentary and Active Time in Toddlers with and without XXXX .

answer: @entity1


abstract: BACKGROUND: High-flexion TKA prostheses are designed to improve flexion and clinical outcomes. Increased knee flexion can increase implant loads and fixation stresses, creating concerns of @entity2 . Whether these goals can be achieved without @entity2 is unclear. QUESTIONS/PURPOSES: We assessed @entity1 relief, knee motion, function, incidence of @entity2 , and radiographic appearance in @entity0 with a mobile-bearing high-flexion TKA and determined whether preoperative knee flexion affects postoperative knee flexion. @entity0 AND METHODS: We prospectively followed all 142 @entity0 implanted with 154 mobile-bearing high-flexion TKAs between 2004 and 2007. We obtained Knee Society scores (KSS) and assessed radiographs for loosening. Minimum followup was 24 months (mean, 46 months; range, 24-79 months). RESULTS: Average knee flexion improved from 123   to 129  . @entity0 with preoperative flexion of 100   to 120   had a greater postoperative flexion increase (mean, 13  ; range, 114  -126  ) than @entity0 with preoperative flexion of greater than 120   (mean, 3.0  ; range, 128  -131  ). The mean KSS improved from 41 to 95 postoperatively. @entity0 with preoperative flexion of less than 120   had a greater improvement in KSS (62 versus 48). Posterior femoral radiolucent lines were observed in 43% without evidence of prosthetic loosening. CONCLUSIONS: Our data were similar to those reported in @entity0 implanted with traditional and other designs of high-flexion TKA. We found no increased incidence of @entity2 , although a higher than expected incidence of posterior femoral radiolucent lines merit continued observation. @entity0 with less preoperative motion were more likely to benefit from a high-flexion TKA.

title: Can a high-flexion total knee arthroplasty relieve XXXX and restore function without @entity2 ?

answer: @entity1


abstract: OBJECTIVE: To evaluate the predictive value of three-dimensional (3D)-power Doppler sonography on recurrent @entity2 . MATERIALS AND METHODS: The study @entity0 were divided into a recurrent @entity2 group (30 cases) and a normal pregnancy group (21 cases). Measurement of endometrial thickness was performed using two-dimensional transvaginal ultrasound in the midluteal phase. The endometrial volume, vascularization index (VI), flow index (FI), and @entity1 ( @entity1 ) in midluteal and placenta volume, as well as the VI, FI, and @entity1 of early pregnancy were measured using Virtual Organ Computer-aided Analysis of 3D-power Doppler ultrasound. RESULTS: Endometrial thickness, endometrial volume, endometrial vascular data, VI, FI, and @entity1 of the midluteal phase were lower in the recurrent @entity2 group compared with the normal pregnancy group (p  <  0.05). Placental volume, VI, and @entity1 during early pregnancy were lower in the @entity2 group compared with the normal pregnancy group (p  <  0.05). There was no significant change in FI between the recurrent @entity2 and control groups during early pregnancy (p  >  0.05). The predictive accuracy of endometrial thickness, endometrial volume, VI, FI, and @entity1 in the midluteal phase, and placenta volume, VI, FI, and @entity1 in early pregnancy as measured by the receiver operating characteristic curve to predict @entity2 before 12 gestational weeks in @entity0 was 0.681, 0.876, 0.770, 0.720, 0.879, 0.771, 0.907, 0.592, respectively. CONCLUSION: The 3D-power Doppler ultrasound is a more comprehensive and sensitive method for evaluating endometrial receptivity. Endometrial volume, VI, FI, and @entity1 in the midluteal phase, as well as VI in early pregnancy, can be considered as predictive factors for recurrent @entity2 .

title: Decreased endometrial vascularity and receptivity in unexplained recurrent XXXX @entity0 during midluteal and early pregnancy phases.

answer: @entity2


abstract: @entity3 is defined as the systemic inflammatory response to @entity2 . @entity7 ( @entity7 ) plays an important role in @entity1 processes by initiating the production of inflammatory mediators. The role of cytosolic PLA ( @entity8 ) has not yet been identified in inflammatory and infectious disease clinical settings. The aim of the present research was to determine whether @entity8 ) activity has a role during @entity3 . Since neutrophil activation has been documented during @entity3 , these cells were chosen as a model to evaluate the function of @entity8 ) in this clinical setting. @entity8 )was studied at 3 levels: activity, protein expression, and messenger RNA (mRNA). Neutrophils from 32 septic @entity0 with and without @entity5 were examined. @entity8 ) activity was measured using labeled @entity6 vesicles as a substrate, and total @entity7 was determined by the release of labeled @entity4 from prelabeled cells. A significant increase in @entity8 activity, protein expression, and total @entity7 activity in neutrophils was detected during @entity3 . mRNA levels, detected by reverse transcriptase-polymerase chain reaction, were significantly higher during @entity3 , indicating that the increase in the amount of @entity8 ) is regulated on the mRNA level. The significant elevation of @entity8 ) activity and expression in neutrophils during @entity3 suggests that this enzyme plays a major role in neutrophil function in this clinical setting. (Blood. 2000;95:660-665)

title: Elevated cytosolic @entity7 expression and activity in @entity0 neutrophils during XXXX .

answer: @entity3


abstract: OBJECTIVE: The purpose of this study was to facilitate interpretation of @entity1 (MAG3) diuretic scans by identifying key interpretative variables and developing a predictive model for computer-assisted diagnosis. MATERIALS AND METHODS: Ninety-seven studies were randomly selected from an archived database of MAG3 baseline and @entity0 acquisitions and scan interpretations (obstruction, equivocal finding, or no obstruction) derived from a consensus of three experts. Sixty-one studies (120 kidneys) were randomly chosen to build a predictive model for diagnosing or excluding obstruction. The other 36 studies (71 kidneys) composed the validation group. The probability of normal drainage (no obstruction) at the baseline acquisition and the probability of no obstruction, equivocal finding, or obstruction after @entity0 administration were determined by logistic regression analysis and proportional odds modeling of MAG3 renographic data. RESULTS: The single most important baseline variable for excluding obstruction was the ratio of postvoid counts to maximum counts. Renal counts in the last minute of @entity0 acquisition divided by the maximum baseline acquisition renal counts and time to half-maximum counts after @entity0 administration in a pelvic region of interest were the critical variables for determining obstruction. The area under the receiver operating characteristic curve (AUC) for predicting normal drainage in the validation sample was 0.93 (standard error, 0.02); sensitivity, 85%; specificity, 93%. The AUC for the diagnosis of obstruction after @entity0 administration was 0.84 (standard error, 0.06); sensitivity, 82%; specificity, 83%. CONCLUSION: A predictive system has been developed that provides a promising computer-assisted diagnosis approach to the interpretation of MAG3 diuretic renal scans; this system has also identified the key variables required for scan interpretation.

title: Key variables for interpreting XXXX diuretic scans: development and validation of a predictive model.

answer: @entity1


abstract: UNASSIGNED: The damage caused by @entity7 is permanent, and has been recognized as a public health problem in a number of regions of the world. Although multiple studies provided evidence that @entity6 ( @entity8 ) elicits adverse effects on reproductive function, the effect of @entity4 on female germ cell development is not well understood. Therefore, the present study aimed at evaluating the effect of @entity4 treatments on in vivo maturation and developmental potential of @entity0 oocytes, in which female ICR @entity0 were treated with a range of doses (0, 30, 60, and 150 mg/L) of @entity8 . After treatment, @entity0 were superovulated to collect ovulated oocytes. The effects of @entity8 on oocyte quality, fertilization potential and early embryonic development were evaluated, as well as the underlying mechanisms were primarily investigated. The findings of this study showed that @entity8 treatment resulted in abnormal spindle configuration, actin cap formation, and cortical granule-free domain formation. Additionally, overexposure of @entity0 to @entity8 notably reduced @entity3 production and mitochondrial membrane potential, further influencing in vitro fertilization and subsequent embryonic development. These results indicated that @entity8 treatment impairs the subsequent embryonic developmental potential of the oocytes. In conclusion, overexposure to @entity4 in vivo was associated with a significant disruption of cytoskeletal dynamics and decreased oocyte quality, affecting the oocyte's subsequent fertilization and embryonic development. Results of this study provide a rationale for treating @entity1 such as @entity2 or @entity5 caused by environmental contaminants.    2015 Wiley Periodicals, Inc. Environ Toxicol, 2015.

title: XXXX impairs oocyte maturation and subsequent embryonic development in @entity0 .

answer: @entity4


abstract: OBJECTIVE: To analyze the relationship between periodontal condition and premature @entity4 ( @entity6 ) in order to provide basis to keep pregnant @entity0 from @entity2 . METHODS: 18 cases of preterm pregnant @entity0 with @entity6 (Group @entity6 ) and 20 cases of full-term pregnant @entity0 with @entity6 (Group @entity6 ) were selected as the study group, and 28 cases of full-term normal pregnant @entity0 were selected as the control group. Everyone's plaque index (PLI), @entity3 ( @entity3 ) and sulcular bleeding index (SBI) were checked and recorded. Meanwhile, immunohistochemical method was used to detect the distribution and expression of @entity5 ( @entity5 ) in fetal membrane of cervix. The relationship between the expression of @entity5 and @entity6 was analyzed. RESULTS: The expression of @entity5 in the pregnant @entity0 with @entity6 (Group @entity6 and Group @entity6 ) was higher than that in the control group. There was no relationship between the expression of @entity5 in chorion and @entity3 (r = 0.053, P = 0.075). The expression of @entity5 in chorion had direct correlation with SBI (r = 0.433, P < 0.05) and PLI (r = 0.310, P < 0.05). The expression of @entity5 in amniotic membrane hadn't dependence with @entity3 (r = 0.077, P = 0.597), while had direct correlation with SBI (r = 0.430, P < 0.05) and PLI (r = 0.324, P < 0.05). CONCLUSION: @entity5 was involved in the pathological process of @entity6 and periodontal @entity1 .

title: [Study on the relationship between the expression of XXXX and premature @entity4 as pregnant @entity0 with periodontal @entity1 ].

answer: @entity5


abstract: UNASSIGNED: Fourier Transform InfraRed (FTIR) spectroscopy coupled to microscopy (IR imaging) has shown unique advantages in detecting morphological and molecular pathologic alterations in biological tissues. The aim of this study was to evaluate the potential of IR imaging as a diagnostic tool to identify characteristics of breast epithelial cells and the stroma. In this study a total of 19 breast tissue samples were obtained from 13 @entity0 . For 6 of the @entity0 , we also obtained Non-Adjacent Non-Tumor tissue samples. Infrared images were recorded on the main cell/tissue types identified in all breast tissue samples. Unsupervised Principal Component Analyses and supervised Partial Least Square Discriminant Analyses (PLS-DA) were used to discriminate spectra. Leave-one-out cross-validation was used to evaluate the performance of PLS-DA models. Our results show that IR imaging coupled with PLS-DA can efficiently identify the main cell types present in FFPE breast tissue sections, i.e. epithelial cells, lymphocytes, connective tissue, vascular tissue and erythrocytes. A second PLS-DA model could distinguish normal and @entity1 breast epithelial cells in the breast tissue sections. A @entity0 -specific model reached particularly high sensitivity, specificity and MCC rates. Finally, we showed that the stroma located close or at distance from the @entity1 exhibits distinct spectral characteristics. In conclusion FTIR imaging combined with computational algorithms could be an accurate, rapid and objective tool to identify/quantify breast epithelial cells and differentiate @entity1 from normal breast tissue as well as normal from @entity1 , paving the way to the establishment of a potential complementary tool to ensure safe @entity1 margins.

title: Characterization of XXXX breast cancer tissues by infrared imaging.

answer: @entity0


abstract: UNASSIGNED: A field experiment was conducted in eight 13.6-MT steel bins containing 6.8 MT each of @entity0 to assess efficacy of @entity3 or SF fumigant to control @entity2 -resistant and susceptible Rhyzopertha dominica (F.) and @entity1 (Herbst). Approximately 400 adults of each type of beetle were added to each bin. Additionally, muslin bags containing immature stages and adults, with their respective diets, were also placed in bins. Four bins were fumigated with SF and others were untreated control bins. The SF dosages in treated bins ranged from 1,196-1,467   mg-h/liter. Mortality of adults in each bag was assessed 5   d postfumigation; diet minus adults was incubated in a jar, and number of adults counted after 8 wk. No significant change occurred in number of insect-damaged kernels in SF-treated bins. In trier samples from SF-treated bins, R. dominica numbers declined from 24 prefumigation to 0 at 3- and 6-wk postfumigation; @entity1 numbers were unchanged. In WBII traps from SF-treated bins, numbers R. dominica and @entity1 declined from 25 and 33, respectively, prefumigation to 0 or near 0 at 3- and 6-wk postfumigation. Mortalities of resistant and susceptible adult R. dominica, and adult and large larvae of @entity1 in SF-treated bags was 100%. For all four types of beetles, adult numbers in jars associated with SF-treated bins were 0 or near 0. Results show SF is effective against all life stages of @entity2 -resistant R. dominica and @entity1 , and can be used for @entity2 resistance management.

title: Effectiveness of @entity3 Fumigation for the Control of @entity2 -Resistant Grain Insects Infesting Stored XXXX .

answer: @entity0


abstract: BACKGROUND: Testing for oncogenic @entity2 ) DNA at a 1.0-pg/mL threshold represents a promising approach for colposcopy triage of @entity5 ( @entity5 ), but not for @entity3 ( @entity3 ). Considering age or viral load could improve colposcopy triage. METHODS: We determined the sensitivity for detecting @entity4 3 (CIN3) and @entity1 and the percentage of referrals for colposcopy using HPV testing and repeat thin-layer cytopathology in 2198 @entity0 with @entity5 and in 848 @entity0 with @entity3 enrolled in ALTS from November 1996 through December 1998. We analyzed results by age and at two thresholds for HPV load and repeat cytopathology. RESULTS: For @entity5 , the overall sensitivity of HPV testing at 1.0 pg/mL was 96.1% (95% confidence interval [CI] = 92.8 to 99.5%) and varied minimally with age (range, 93.9% to 97.8%). HPV testing at this threshold would refer 31.2% (95% CI = 28.0% to 34.3%) of @entity0 aged 29 years or older as compared with more than 65% of younger @entity0 . Among @entity0 aged 29 years or older with @entity5 , referral for repeat cytopathology of @entity5 had a sensitivity of 90.9% (95% CI = 81.1% to 100.0%) and would refer 50.1% (95% CI = 46.7 to 53.5%). Among all @entity5 , HPV testing using a 10.0-pg/mL threshold decreased sensitivity to 91.5% and referrals to 41.7%. More than 63% of @entity3 would have been referred using any strategy achieving 90% sensitivity. CONCLUSION: For @entity0 with @entity5 , HPV testing was highly sensitive for detecting CIN3 and @entity1 with dramatically fewer referrals of older @entity0 . Neither a single HPV test nor repeat cytopathology provides useful triage for @entity0 with @entity3 .

title: Effects of age and @entity0 papilloma viral load on colposcopy triage: data from the randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade XXXX Triage Study (ALTS).

answer: @entity3


abstract: UNASSIGNED: Objective: Thin supporting tissues may cause @entity2 and esthetic problems in the anterior area. The objectives of this study were to present a simple and reliable radiographic technique to measure thickness of alveolar bone labial to mandibular incisors, and to establish a possible correlation of bone thickness with its tissue biotype. Method and Materials: A metal strip was placed over the @entity2 of the mandibular incisor axis, and a perpendicular occlusal radiograph was taken of 51 @entity0 . @entity0 in routine orthodontic practice before any orthodontic treatment was started were distributed into three groups according to their periodontal biotype (A1, thin with < 2 mm keratinized @entity2 ; A2, thin with > 2 mm; and B, thick with wide zone of keratinized @entity2 ), as described by M  ller and Eger.1 Radiographs were scanned and thickness of gingival tissue and of bone at two levels (at the bone crest and at 3 mm below the bone crest) was measured to the nearest 0.1 mm. Measurements of soft tissue and bone thickness were compared and correlated. Results: Groups @entity3 showed a significant difference in bone thickness at the bone crest. Correlation of @entity1 was only found in gingival biotype B at 3 mm below the bone crest level only (R = 0.290; P < .001). No other correlation between @entity1 was observed in any group. Conclusions: The radiographic technique proposed in this study is a simple and reliable method for calibrating the amount of buccal bone in the mandibular anterior area. It is a cheap and fast diagnostic tool that may help determine the amount of buccal @entity1 , and therefore avoid excessive radiation to @entity0 . Groups @entity3 showed a significant difference in bone thickness at the bone crest. Although not significant, group A1 showed the lowest values of @entity1 , whereas group B showed the highest @entity1 . A clear correlation between thickness of bone and @entity2 3 mm below the cementoenamel junction was found in group B.

title: A simple method for measuring thickness of XXXX and labial bone of mandibular incisors.

answer: @entity2


abstract: This analytic (phase II) study aimed to investigate the hypothesis that the decline in serum @entity3 -inhibiting activity (MIA) levels following initiation of treatment might have prognostic value. The mean serum @entity4 dehydrogenase (LDH), MIA and S100 levels in @entity0 with @entity3 before treatment were higher than in the control group. @entity0 with visceral dissemination had much higher mean serum MIA levels than @entity0 with nodal spread only. A regression model was constructed to analyse the prognostic factors in @entity0 with advanced stage @entity3 . Therapy included surgical excision or lymph node dissection, hypofractionated radiotherapy, and immunotherapy or chemotherapy. Blood samples were collected within 24 h before the initiation of systemic treatment and two or three times more at 20-28 day intervals. Overall survival was investigated by univariate analysis, and correlation with clinical factors was compared using the log-rank test. Gender, primary @entity2 site, surgery, radiation therapy, serum S100 levels before systemic treatment and choice of chemotherapy were not correlated with the outcome. In addition to the stage of disease, low serum LDH levels before systemic treatment and a decline in serum MIA levels following initiation of systemic treatment predicted a favourable outcome. @entity1 to visceral organs was associated with higher serum MIA levels. Persistence of high serum MIA levels despite systemic treatment predicts an unfavourable prognosis.

title: Prognostic significance of XXXX inhibiting activity levels in @entity3 .

answer: @entity3


abstract: OBJECTIVE: Matrix metalloproteinases (MMP) and @entity9 ( @entity9 ) have been found in high concentrations in @entity4 . Because MMP and @entity9 may play a part in the causation of the @entity1 seen in @entity2 ( @entity2 ) @entity11 their occurrence was examined. DESIGN: Pleural effusion fluid and plasma concentrations of @entity10 , @entity5 , @entity7 , @entity12 , @entity6 , @entity9 and @entity8 were determined by ELISA in 21 @entity0 with @entity11 . To adjust for the total protein content, respective ratios were calculated. Activities of @entity5 and @entity6 were measured by gelatine zymography and the @entity6 / @entity5 ratios calculated. Pleural effusions and plasma of 15 @entity0 with @entity3 ( @entity3 ) and plasma of 15 healthy @entity0 (CON) served as controls. RESULTS: Immunoreactive pleural fluid concentrations of @entity10 , @entity5 , @entity12 , and @entity6 were higher in @entity2 compared to @entity3 , but plasma concentrations were not different between the groups. @entity2 pleural fluid concentrations of @entity10 , @entity5 , @entity9 , and @entity8 were higher compared to @entity2 plasma. @entity7 was found in trace amounts only. The @entity6 /total protein ratios in pleural fluid were higher in @entity2 compared to @entity3 (0.4492+/-0.1633 vs 0.0364+/-0.0145, P<0.005) but the @entity9 ratios were lower (139.0+/-28.7 vs 517.8+/-183.7, P<0.0005). In @entity2 pleural fluid vs @entity2 plasma, the respective @entity10 , @entity5 , @entity9 , and @entity8 ratios were increased (0.46+/-0.10 vs 0.17+/-0.02; 25.2+/-2.8 vs 4.2+/-0.9; 139.0+/-28.7 vs 27.8+/-8.2; 0.67+/-0.13 vs 0.18+/-0.04, P<0.0005 each). Gelatine zymography demonstrated @entity5 and @entity6 bands of different brightness in @entity2 effusions but in @entity3 effusions the @entity6 band was barely visible. The @entity6 / @entity5 effusion ratios were therefore higher in @entity2 compared to @entity3 (0.46+/-0.15 vs 0.05+/-0.04, P<0.0005). CONCLUSION: Compartmentalized @entity10 , @entity5 , @entity9 , and @entity8 and, compared to @entity3 , a surplus of @entity10 , @entity5 , @entity12 , and @entity6 in the pleural space obviously contribute to the fibrotic reactions in @entity11 .

title: Occurrence of matrix metalloproteinases and XXXX in @entity2 @entity11 .

answer: @entity9


abstract: BACKGROUND: Current research emphasizes the high prevalence and costs of @entity2  ( @entity2 ). The STarT Back Tool was designed to support primary care decision making for treatment by helping to determine the treatment prognosis of @entity0 with non-specific @entity2 . The German version is the STarT-G. The cross-cultural translation of the tool followed a structured and widely accepted process but to date it was only partially validated with a small sample. The aim of the study was to test the psychometric properties construct validity, discriminative ability, internal consistency and test-retest-reliability of the STarT-G and to compare them with values given for the original English version. METHODS: A consecutive cohort study with a two-week retest was conducted among @entity0 with non-specific @entity2 , aged 18 to 60  years, from primary care practices. Questionnaires were collected before the first consultation, and two weeks later by post, using the following reference standards: the Roland and Morris disability questionnaire, the Tampa Scale of Kinesiophobia, the Pain Catastrophizing Scale and the Hospital Anxiety and @entity1 Scale. Psychometric properties examined included the tool's discriminative abilities, whether the psychosocial subscale was one factor, internal consistency, item redundancy, test-retest reliability and floor and ceiling effects. RESULTS: There were 228 @entity0 recruited with a mean age of 42.2 (SD 11.0) years, and 53  % were female. The areas under the curve (AUC) for discriminative ability ranged from 0.70 (STarT-G Subscale - Pain Catastrophizing Scale; CI95 0.63, 0.78) to 0.77 (STarT-G Total - Composite reference standard, CI95 0.60, 0.94). Factor loadings ranged from 0.49 to 0.74. Cronbach's alpha testing the internal consistency and redundancy for the total/subscale scores were a   =   0.52/0.55 respectively. The STarT-G test-retest reliability Kappa values for the total/subscale scores were 0.67/0.68 respectively. No floor or ceiling effects were present. CONCLUSIONS: The STarT-G shows acceptable psychometric properties although not in exact agreement with the original English version. The items previously regarded as a psychosocial subscale may be better seen as an index of different individual psychosocial constructs. The relevance of using the tool at the point of consultation should be further examined.

title: Validation of the German version of the STarT-Back Tool (STarT-G): a cohort study with XXXX from primary care practices.

answer: @entity0


abstract: BACKGROUND: Little is known regarding the neurocognitive impact of @entity4 resection. OBJECTIVE: To clarify subacute surgery-related changes in neurocognitive functioning (NCF) in @entity0 with left (LTL) and right (RTL) @entity4 . METHODS: @entity0 with @entity2 in the LTL (n = 45) or RTL (n = 19) completed comprehensive pre- and postsurgical neuropsychological assessments. NCF was analyzed with 2-way mixed design repeated-measures analysis of variance, with hemisphere (LTL or RTL) as an independent between-subjects factor and pre- and postoperative NCF as a within-subjects factor. RESULTS: About 60% of @entity0 with @entity2 and 40% with @entity3 exhibited significant worsening on at least 1 NCF test. Domains most commonly impacted included verbal memory and executive functioning. @entity0 with @entity1 showed greater decline than @entity0 with @entity1 on verbal memory and confrontation naming tests. Nonetheless, over one-third of @entity0 with @entity3 also showed verbal memory decline. CONCLUSION: In @entity0 with @entity4 , NCF decline in the subacute postoperative period is common. As expected, @entity0 with @entity1 show more frequent and severe decline than @entity0 with @entity1 , particularly on verbally mediated measures. However, a considerable proportion of @entity0 with @entity1 also exhibit decline across various domains, even those typically associated with left hemisphere structures, such as verbal memory. While @entity0 with @entity3 may show even greater decline in visuospatial memory, this domain was not assessed. Nonetheless, neuropsychological assessment can identify acquired deficits and help facilitate early intervention in @entity0 with @entity4 .

title: Neurocognitive Changes Associated With Surgical Resection of Left and Right XXXX .

answer: @entity4


abstract: The majority of high-grade serous @entity3 cases are detected in advanced stages when treatment options are limited. Surgery is less effective at eradicating the disease when it is widespread, resulting in high rates of disease relapse and chemoresistance. Current screening techniques are ineffective for early @entity1 detection and consequently, @entity4 mutations carriers, with an increased risk for developing high-grade serous @entity3 , elect to undergo risk-reducing surgery. While prophylactic surgery is associated with a significant reduction in the risk of @entity1 development, it also results in surgical menopause and significant adverse side effects. The development of efficient early-stage screening protocols and imaging technologies is critical to improving the outcome and quality of life for current @entity0 and @entity0 at increased risk. In addition, more accurate animal models are necessary in order to provide relevant in vivo testing systems and advance our understanding of the disease origin and progression. Moreover, both genetically engineered and @entity1 xenograft animal models enable the preclinical testing of novel imaging techniques and molecularly targeted therapies as they become available. Recent advances in xenograft technologies have made possible the creation of avatar @entity2 , personalized tumorgrafts, which can be used as therapy testing surrogates for individual @entity0 prior to or during treatment. High-grade serous @entity3 may be an ideal candidate for use with avatar models based on key characteristics of the tumorgraft platform. This review explores multiple strategies, including novel imaging and screening technologies in both @entity0 and animal models, aimed at detecting @entity1 in the early-stages and improving the disease prognosis.

title: Advances in XXXX screening, imaging, and avatar technologies for high-grade serous @entity3 .

answer: @entity1


abstract: BACKGROUND: Using a proteomic approach, we aimed to identify and compare the urinary excretion of proteins involved in lipid transport and metabolism in @entity0 with @entity4 and @entity6 (CAL), hypocitraturia (CIT), and normal metabolic work-up (NM), and in healthy controls (HCs). Additionally, we aimed to confirm these results using ELISA, and to examine the relationship between the urinary excretion of selected proteins with demographic, dietary, blood, and urinary parameters. METHODS: Prospective, controlled, pilot study of pooled urine from CAL, @entity8 , and NM versus age- and gender-matched HCs, using liquid chromatography-mass spectrometry. Relative protein abundance was estimated using spectral counting. Results were confirmed by ELISA performed on individual samples. RESULTS: Of the 1,813 proteins identified, 230 met the above criteria. Of those, 5 proteins ( @entity5 [ @entity5 ]; @entity10 [ @entity12 [APOA3]; @entity3 -binding protein, liver [ @entity11 ]; @entity3 -binding protein, adipocyte [ @entity7 ) involved in lipid metabolism and transport were found in the CAL group, with significant differences compared with HCs. ELISA analysis indicated statistically significant differences in the urinary excretion of @entity9 , @entity10 , and @entity11 in the CAL group compared with HCs. Twenty-four-hour urinary @entity2 excretion correlated significantly with concentrations of @entity9 (r   =   0.77, p   <   0.001), and @entity11 (r   =   0.80, p   =   0.005). CONCLUSIONS: We provide proteomic data showing increased urinary excretion of lipid metabolism/transport-related proteins in @entity0 with @entity4 and @entity6 . These findings suggest that @entity1 might play a @entity4 formation.

title: Marked increase in urinary excretion of apolipoproteins in @entity0 with nephrolithiasis associated with XXXX .

answer: @entity6


abstract: INTRODUCTION: @entity2 induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of @entity0 therapy. AIM: To evaluate the effect of the topical application of @entity12 ( @entity13 ), a @entity5 donor, on @entity7 ( @entity7 )-induced @entity9 in hamsters. MATERIALS AND METHODS: @entity9 was induced in male hamsters by two intraperitoneal administrations of @entity7 on the first and second days of the experiment (60 and 40 mg/kg, respectively) followed by mechanical @entity3 on the fourth day. Animals received saline, HPMC or HPMC/ @entity13 (0.1, 0.5 or 2.0 mM) 1 h prior to the @entity7 injection and twice a day for 10 or 14 days. Samples of cheek pouches were harvested for: histopathological analysis, @entity4 and @entity6 levels, immunohistochemical staining for @entity10 , @entity4 , @entity6 , Ki67 and @entity8 RII and a TUNEL assay. The presence and levels of 39 bacterial taxa were analyzed using the Checkerboard DNA-DNA hybridization method. The profiles of NO released from the HPMC/ @entity13 formulations were characterized using chemiluminescence. RESULTS: The HPMC/ @entity13 formulations were found to provide sustained release of NO for more than 4 h at concentration-dependent rates of 14 to 80 nmol/mL/h. Treatment with HPMC/ @entity13 (0.5 mM) significantly reduced @entity1 , inflammatory alterations and cell death associated with @entity7 -induced @entity9 on day 14 but not on day 10. HPMC/ @entity13 administration also reversed the inhibitory effect of @entity7 on cell proliferation on day 14. In addition, we observed that the chemotherapy significantly increased the levels and/or prevalence of several bacterial species. CONCLUSION: Topical HPMC/ @entity13 accelerates mucosal recovery, reduces inflammatory parameters, speeds up re-epithelization and decreases levels of @entity11 .

title: @entity12 accelerates recovery from XXXX -induced @entity9 .

answer: @entity7


abstract: AIM: To investigate the features of crush @entity1 in Sichuan earthquake victims using chest digital radiography (CDR). METHODS: We retrospectively reviewed 772 CDR of 417 females and 355 males who had suffered crush @entity1 in the Sichuan earthquake. @entity0 age ranged from 0.5 to 103 years. CDR was performed between May 12, 2008 and June 7, 2008. We looked for @entity5 , @entity4 . RESULTS: Antero-posterior (AP) and lateral CDR were obtained in 349 @entity0 , the remaining 423 @entity0 underwent only AP CDR. Thoracic cage @entity2 , @entity4 and @entity1 were noted in 331 (42.9%; 95% CI: 39.4%-46.4%), 67 and 135 @entity0 , respectively. Of the 256 @entity0 with @entity2 , the mean number of @entity2 per @entity0 was 3. @entity2 were mostly distributed from the 3rd through to the 8th ribs and the vast majority involved posterior and lateral locations along the rib. @entity2 had a significant positive association with non-rib @entity2 , @entity4 and @entity1 (P < 0.001). The number of @entity2 and @entity4 were significant factors associated with @entity0 @entity3 . CONCLUSION: Earthquake-related crush @entity1 has the potential for multiple @entity2 . The high number of @entity2 and @entity4 were significant factors which needed appropriate medical treatment.

title: Digital radiography of crush XXXX in the Sichuan earthquake.

answer: @entity1


abstract: OBJECTIVE: To provide a preliminary assessment of the efficacy and safety of @entity5 treatment of @entity3 . DESIGN: A placebo-controlled, double-blind, random-allocation crossover trial of 6 weeks of @entity4 . SETTING: An outpatient clinical trials unit. @entity0 : Twenty-five @entity0 with @entity3 (mean age, 40 years; 19 [76%] @entity0 ; mean duration of illness, 7.0 years) were recruited from a research and clinic registry. Five @entity0 withdrew from the trial. INTERVENTIONS: All @entity0 were scheduled to receive @entity5 (0.1-0.2 mg) or a placebo for 6 weeks in each treatment. MAIN OUTCOME MEASURES: Self-administered questionnaires were completed at the beginning and end of each treatment arm that asked @entity0 to rate the severity of their symptoms on a visual analogue scale. The Medical Outcomes Study 36-Item Short-Form Health Survey, a reaction time test, and a treadmill exercise test were used to assess functional status. Blood pressure, heart rate, and plasma @entity2 levels were obtained at baseline. Blood pressure and heart rate were recorded at the end of the exercise test and monitored at all subsequent visits. RESULTS: At baseline, the study @entity0 reported symptom severity greater than 5 for most symptoms, and all had evidence of marked @entity1 . No improvement was observed in the severity of any symptom or in any test of function for the 20 @entity0 who completed both arms of the trial. Blood pressure and heart rate readings were unaffected by treatment, and plasma @entity2 levels did not differ from those of a healthy control group. The incidence of adverse experiences was similar in the @entity4 and placebo arms of the trial. CONCLUSION: Low-dose @entity4 does not provide sufficient benefit to be evident in a preliminary blinded trial of unselected @entity0 with @entity3 .

title: A preliminary placebo-controlled crossover trial of @entity4 for XXXX .

answer: @entity3