abstract: BACKGROUND: @entity1 ( @entity1 ) causes not only somatic, but also @entity2 regardless of the @entity0 *  age or the course of the disease. The Brief International Cognitive Assessment for @entity1 (BICAMS) test, published in 2011, is a short cognitive questionnaire: a fast, reliable, sensitive and specific tool for the evaluation of the @entity0 *  cognitive state. OBJECTIVES: Our primary objective was to assess the validity of the Hungarian version of the BICAMS test. Our secondary objective was to evaluate the impact of the @entity2 on the @entity0 * s quality of life and @entity3 * s impact on the @entity0 *  cognitive state. METHODS: 65 RR- @entity1 @entity0 and 65 age, sex and education matched healthy control (HC) subjects completed the test and were retested after 3 weeks. The @entity0 also completed the @entity1 Quality of Life 54 (MSQoL54) and the Fatigue Impact Scale (FIS) assessments. Group differences were calculated by paired sample T-tests. The test-retest reliability was measured by intraclass correlation coefficients. To analyze the difference between the test-retest performances of the two groups we used two-way repeated measures ANOVA where the BICAMS battery was the single composite outcome and one-way repeated measures ANOVA. To assess the impact of the @entity2 on the @entity0 *  quality of life and @entity3 * s impact on the cognitive state, we examined the correlations between results in the BICAMS and the MSQoL54 and FIS. RESULTS: We found significant difference (p <=0.001, p=0.017 in the first CVLT-II assessment) between @entity1 @entity0 and members of the HC group in all four evaluated parameters of BICAMS test in both sessions. The correlation coefficients were very strong between the tests and retests (r>0.8; p<0.001; r=0.678, p<0.001 between the CVLT-II assessments). We found that the HC group performed significantly (p=0.020) better in the retest sessions as compared to their original performance than the @entity0 did and this difference is solely due to the difference between the CVLT-II performances. We have found significant negative correlation between the @entity0 *  cognitive function and the @entity3 score (r<-0.3, p<0.05). Seven of the MSQoL-54 subscales correlated with the BICAMS performance (r>0.3; p<0.05). CONCLUSIONS: The Hungarian version of the BICAMS test is a valid and reliable method for the evaluation of @entity1 @entity0 *  cognitive function. It seems that because of the short retest period, the members of the HC group remembered the CVLT-II words thus performed better than the @entity0 did. Also apparently @entity3 can have a negative impact on the @entity0 *  cognitive state, and @entity2 could worsen the @entity0 *  quality of life.

title: The Hungarian validation of the Brief International Cognitive Assessment for XXXX (BICAMS) battery and the correlation of @entity2 with @entity3 and quality of life.

answer: @entity1


abstract: INTRODUCTION: Fasting and postprandial plasma @entity2 (FPG, @entity4 ) control are both necessary to achieve glycosylated hemoglobin (HbA(1c)) regulation goals. Liraglutide, based on its @entity5 ( @entity5 )-mediated pharmacology and pharmacokinetics may reduce HbA(1c) through both FPG and @entity4 levels. The objective of the present study was to investigate the effect of once-daily liraglutide (0.6, 1.2, and 1.8 mg) at steady state on FPG, @entity4 , postprandial insulin, and gastric emptying. METHODS: Eighteen subjects with type 2 @entity1 , aged 18-70 years, with a body mass index of 18.5-40 kg/m(2) and HbA(1c) of 7.0%-9.5% were included in this single-centre, randomized, placebo-controlled, double-blind, two-period, cross over trial. @entity0 were randomized into two groups (A or B). Group A received oncedaily liraglutide for 3 weeks, followed by a 3-4-week washout period and 3 weeks of oncedaily placebo. Group B was treated as for Group A, but treatment periods were reversed (ie, placebo followed by liraglutide). A meal test was performed at steady-state liraglutide/placebo doses of 0.6, 1.2, and 1.8 mg/day. Plasma @entity2 , insulin, and @entity3 ( @entity3 ) concentrations (to assess gastric emptying) were measured pre- and postmeal. RESULTS: @entity4 levels significantly decreased (P<0.001) after all three liraglutide doses when compared with placebo. This decrease was also apparent when corrected for baseline (incremental excursions), with the exception of average incremental increase calculated as area under the concentration curve (AUC) over the fasting value from time zero to 5 hours (iAUC (0-5 h)/5 hours) after liraglutide 0.6 mg, where there was a trend to decrease (P=0.082). In addition, FPG levels significantly decreased at all three liraglutide dose levels when compared to placebo (P<0.001). Fasting and postprandial insulin levels significantly increased with liraglutide versus placebo at all doses studied (P<0.001). A significant delay in gastric emptying during the first hour postmeal was observed at the two highest liraglutide doses versus placebo. CONCLUSION: In addition to lowering FPG levels, liraglutide improves @entity4 levels (absolute and incremental) possibly by both stimulating postprandial insulin secretion and delaying gastric emptying.

title: The once-daily @entity0 @entity5 ( @entity5 ) analog liraglutide improves postprandial XXXX levels in type 2 @entity1 @entity0 .

answer: @entity2


abstract: OBJECTIVE: @entity1 is a common manifestation of systemic @entity2 . Apart from traditional risk factors, genetic determinants, such as polymorphisms of the @entity3 angiotensin system (RAS), may be relevant in modulating the @entity2 process leading to @entity1 . In this study, we investigated the role of @entity4 ( @entity4 ) I/D and @entity9 , @entity5 ( @entity5 ) @entity6 , and angiotensin type 1 receptor ( @entity7 ) @entity8 polymorphisms in modulating the susceptibility to the disease. METHODS: Eight hundred twenty-one consecutive @entity0 with severe @entity1 (>= 70%) and 847 control subjects were investigated. RESULTS: A significant difference in genotype distribution (P < .0001) and allele frequency (P < .0001) between @entity0 and controls for the @entity4 I/D polymorphism, but not for the other single-nucleotide polymorphisms investigated, was observed. The @entity4 D allele frequency was significantly higher in @entity0 without traditional risk factors in comparison with that observed in those with at least one risk factor (0.71 vs 0.61; P = .04). The @entity4 D allele significantly influenced @entity1 under dominant, recessive, and additive model of inheritance at both univariate (P < .0001) and multivariate analysis (P < .0001). When the combined effect of RAS unfavorable alleles was considered, @entity0 carrying less than three alleles had a lower risk of @entity1 (odds ratio [OR], 0.79 [0.63-0.99]; P = .05), while carriers of more than four unfavorable alleles had an increased risk (OR, 1.44 [1.12-1.84]; P = .004), in comparison with subjects carrying three or four unfavorable alleles. @entity4 D allele frequency was similar in @entity0 with and without additional @entity2 localizations (0.61 vs 0.62, respectively). CONCLUSIONS: Our findings evidence a role for @entity4 I/D polymorphism in influencing the susceptibility to @entity1 , even in the absence of traditional risk factors. Interestingly, our findings provided further information concerning the role of this polymorphism in modulating the @entity2 process apart from its different localizations.

title: Association between polymorphisms of the XXXX angiotensin system and @entity1 .

answer: @entity3


abstract: Components of the bacterial @entity6 ( @entity7 ) : @entity3 phosphortransferase system (PTS) have multiple regulatory roles in addition to PEP-dependent transport/phosphorylation of numerous @entity4 . We have recently shown that, in an opportunistic @entity0 pathogen, @entity5 , enzyme IIA(Glc) (EIIA(Glc)) interacts with a peptidase that has high sequence similarity to @entity0 insulin-degrading enzymes, called Vibrio insulin-degrading enzyme (vIDE). Although the vIDE-EIIA(Glc) interaction is independent of the phosphorylation state of EIIA(Glc), vIDE shows no peptidase activity unless complexed with the unphosphorylated form of EIIA(Glc). A deletion mutant of ideV, the gene encoding vIDE, shows remarkably lower degrees of survival and virulence than the wild-type strain in @entity1 , implying that vIDE is a virulence factor. In this study, we investigated regulation of ideV expression at the transcriptional level. Primer extension analysis identified two different transcriptional start sites of ideV: P(L) for the longer transcript and P(S) for the shorter transcript. We performed ligand fishing experiments by using the promoter region of ideV and found that the @entity2 receptor protein (CRP) specifically binds to the promoter. DNase I footprinting experiments revealed that CRP binds to a region between the two promoters. In vitro transcription assays showed that CRP activates ideV P(S) transcription in the presence of @entity2 whose concentration is regulated by EIIA(Glc). These results suggest that EIIA(Glc) regulates the expression level of vIDE as well as its activity.

title: Expression of @entity5 insulin-degrading enzyme is regulated by the XXXX -CRP complex.

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in @entity0 with locally advanced @entity3 (SCC). METHODS: This was a prospective phase II study. The primary endpoint was complete response (CR). @entity0 with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly @entity2 -based chemotherapy ( @entity1 40 mg/m2 or @entity4 area under the curve 2). RESULTS: Twenty-one @entity0 were enrolled in this study. Eighteen @entity0 had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable @entity0 , 10 achieved a CR to definitive CRT with 2 further @entity0 rendered disease-free by salvage surgery for an overall CR of 63%. CONCLUSION: This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in @entity0 with locoregional advanced disease who were unable to undergo surgery.    2016 Wiley Periodicals, Inc. Head Neck, 2016.

title: Prospective study of definitive chemoradiation in locally or regionally advanced XXXX .

answer: @entity3


abstract: BACKGROUND: We analyzed the early and long-term quality of life changes occurring in 16 @entity0 undergoing tailored combined surgery for stage I @entity2 ( @entity2 ) and severe @entity4 . METHODS: Mean age was 65 +/- 5 years. All @entity0 had severe @entity4 with severely impaired respiratory function and quality of life. @entity1 resection was performed with sole lung volume reduction (LVR) in 5 @entity0 , separate wedge resection in 3 @entity0 , segmentectomy in 2 @entity0 , and lobectomy in 6 @entity0 . A bilateral LVR was performed in 5 @entity0 . Quality of life was assessed at baseline and every 6 months postoperatively by the Short-form 36 (SF-36) item questionnaire. RESULTS: Mean follow-up was 44 +/- 21 months. All @entity1 were pathologic stage I. There was no hospital mortality nor major morbidity. Significant improvements occurred for up to 36 months in the general health (p = 0.02) domain and for up to 24 months in physical functioning (p = 0.02), role physical (p = 0.005), and general health (p = 0.01) SF-36 domains. Associated improvements regarded @entity3 index (-1.3 +/- 0.6) forced expiratory volume in one second (+0.28 +/- 0.2L), residual volume (-1.18 +/- 0.5L) and 6-minute-walking test distance (+86 +/- 67 m). Actuarial 5-year survival was similar to that of @entity0 with no @entity1 undergoing LVRS during the same period (68% vs 82%, p = not significant). CONCLUSIONS: Our study suggests that selected @entity0 with stage I @entity2 and severe @entity4 may significantly benefit from tailored combined surgery in terms of long-term quality of life and survival.

title: Quality of life after tailored combined surgery for stage I @entity2 and severe XXXX .

answer: @entity4


abstract: BACKGROUND: @entity5 occurs frequently in adolescents, and is often benign. Potential worrisome @entity5 events include those occurring with exertion, concurrent @entity2 , dyspnoea or palpitations, and those with focal or diffuse neurologic changes. CASE: A 16-year-old female was referred to our institution for a history of exercise-induced spells. She was diagnosed since the age of 2 years with @entity3 and postural @entity1 . She had been evaluated at multiple institutions, and was followed by pediatric neurology for a diagnosis of @entity6 . Owing to recurrent @entity4 and a @entity5 requiring resuscitation, an echocardiogram was performed. The right coronary was normal, but the left coronary artery ostium could not be identified well. Doppler patterns were suspicious of an abnormal left coronary artery, and computed tomography angiography was performed. This revealed a single coronary artery arising from the right aortic sinus, with the left coronary artery arising from the proximal coronary trunk and coursing through the infundibular septum. This was surgically treated utilising a left internal mammary artery bypass graft to the left anterior descending coronary artery. A year later, she has not experienced any recurrence of @entity5 , and has returned to athletic activity. CONCLUSION: This case highlights the index of suspicion that must be present when evaluating any @entity0 with @entity5 , both clinically and via echocardiography. A computed tomography angiogram is indicated for better evaluation of coronary artery anatomy when an anomalous coronary cannot be ruled out by echocardiography.

title: Single coronary artery giving rise to an intraseptal left coronary artery in a XXXX presenting with @entity3 .

answer: @entity0


abstract: OBJECTIVE: Some studies about the @entity3 Society checklist for the diagnosis of @entity1 ( @entity1 ) @entity2 ( @entity4 ) suggested that its accuracy was not totally satisfactory. Our study focused to evaluate the two items of the checklist related to the cognitive assessment. METHODS: We assessed 95 consecutive @entity0 with a diagnosis of @entity1 using the UPDRS, Hoehn and Yahr, Schwab and England scales, Pfeffer Functional Activities Questionnaire, MMSE, Clinical @entity2 Rating, clock drawing test, verbal fluency test (animals), digit span, word list battery of CERAD, Frontal Assessment Battery and the 15-item Geriatric Depression Scale The cognitive diagnosis was based on the MDS diagnostic criteria for @entity4 . The checklist was completed later by a blinded investigator. The data were evaluated using descriptive analysis and calculation of sensitivity, and specificity of the checklist for the diagnosis of @entity4 . RESULTS: 33 @entity0 (35%) were diagnosed with @entity4 . The ROC curve showed that the MMSE cut-off score < 26 had the highest accuracy (sensitivity: 94%, specificity: 55%) for the diagnosis of @entity4 . Using the checklist with original cut-off scores we found sensitivity of 97% and specificity of 58%. Using an alternative way to interpret the cognitive assessment of the checklist we found sensitivity of 94% and specificity of 89% for the diagnosis of @entity4 . CONCLUSIONS: Our findings suggest that to improve the accuracy of the checklist, it would be necessary to adjust the way we use and interpret the cut-off scores of the MMSE and of the subtests, without the need to eliminate their use.

title: An analysis of the cognitive items of the XXXX society checklist for the diagnosis of @entity2 in @entity0 with @entity1 .

answer: @entity3


abstract: BACKGROUND: During @entity6 , the inhibition of gastrointestinal (GI) motility together with mucosal barrier dysfunction will lead to increased bacterial translocation and maintenance of @entity2 . The activation of the vagal anti-inflammatory pathway remains an appealing therapeutic strategy in @entity2 . In this respect, selective @entity8 nicotinic @entity5 receptor (a7nAChR) agonists have shown anti-inflammatory properties in several animal models of @entity1 . METHODS: @entity2 was induced in OF-1 @entity0 by cecal ligation and puncture (CLP). GI transit was quantified, and cytokine levels were determined in serum and colon. Colonic permeability was assessed by means of Evans blue injection. We studied the effect of @entity9 , an a7nAChR agonist, on the aforementioned parameters. Splenectomized animals as well as a7nAChR-knock-out animals ( @entity8 ) were included to study the role of splenic macrophages and the a7nAChR during polymicrobial @entity6 . RESULTS: In septic animals, @entity9 significantly @entity3 , lowered systemic and colonic levels of @entity4 , decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing @entity2 -induced @entity7 . @entity8 @entity0 displayed a more severe septic phenotype, whereas @entity9 remarkably was also beneficial in these animals. CONCLUSION: Our results show that peripheral targeting of the vagal anti-inflammatory pathway proves beneficial in an animal model of polymicrobial @entity6 . A major role is allocated to splenic immune cells in the development of @entity2 , as preventive splenectomy was protective for the development of @entity2 . Data on the @entity8 @entity0 suggest that the beneficial effects mediated by @entity9 on @entity1 and motility might be related to activation of other receptors besides the a7nAChR.

title: EFFECT OF @entity9 , AN @entity8 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN XXXX .

answer: @entity0


abstract: AIM: To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in @entity0 with @entity3 (GDM). METHODS: Prospective cohort study of 971  @entity0 who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionnaire assessing moderate and vigorous intensity sports and exercise in the past 3  months. Self-monitored capillary @entity1 values were obtained for the 6-week period following the questionnaire, with optimal glycaemic control defined>= 80% values meeting the targets<5.3mmol/L for fasting and <7.8mmol/ @entity2 -hour after meals. Logistic regression estimated the odds of achieving optimal control; linear regression estimated activity level-specific least square mean @entity1 , as well as between-level mean @entity1 differences. RESULTS: For volume of moderate intensity sports and exercise ([MET*hours]/week), the highest quartile, compared to the lowest, had significantly increased odds of optimal control (OR=1.82 [95% CI: 1.06-3.14] P=0.03). There were significant trends for decreasing mean 1-hour post breakfast, lunch and dinner glycaemia with increasing quartile of moderate activity (all P<0.05). Any participation in vigorous intensity sports and exercise was associated with decreased mean 1-hour post breakfast and lunch glycaemia (both P<0.05). No associations were observed for fasting. CONCLUSION: Higher volumes of moderate intensity sports and exercise, reported shortly after GDM diagnosis, were significantly associated with increased odds of achieving glycaemic control. Clinicians should be aware that unsupervised moderate intensity sports and exercise performed in mid-pregnancy aids in subsequent glycaemic control among @entity0 with GDM.

title: Moderate intensity sports and exercise is associated with glycaemic control in @entity0 with XXXX .

answer: @entity3


abstract: INTRODUCTION: The role of elective nodal irradiation of @entity3 ( @entity3 ) @entity0 treated with radiotherapy remains unclear. We investigated the significance of treating clinically uninvolved lymph nodes by retrospectively analyzing the relationship between loco-regional failure and the irradiated volume. METHODS: Between 1998 and 2003, @entity0 with IA-IIIB @entity3 were treated with radiotherapy. The eligibility criteria for this study were an irradiation dose of 60Gy or more and a clinical response better than stable disease. Typical radiotherapy consisted of 40 Gy/20 fr to the @entity2 volumes (clinical target volume of the @entity2 [CTVp], of the metastatic lymph nodes [CTVn], and of the subclinical nodal region [CTVs]), followed by off-cord boost to CTVp+n to a total dose 60-68 Gy/30-34 fr. The relationship between the sites of recurrence and irradiated volumes was analyzed. RESULTS: A total of 127 @entity0 fulfilled the eligibility criteria. Their median overall and progression-free survival times were 23.5 (range, 4.2-109.7) and 9.0 months (2.2-109.7), respectively. At a median follow-up time of 50.5 months (range, 14.2-83.0) for the surviving @entity0 , the first treatment failure was observed in 95 @entity0 (loco-regional; 41, distant; 42, both; 12). Among the @entity0 with loco-regional failure, in-field recurrence occurred in 38 @entity0 , and four CTVs recurrences associated with CTVp+n failure were observed. No isolated recurrence in CTVs was observed. CONCLUSIONS: In-field loco-regional failure, as well as distant @entity1 , was a major type of failure, and there was no isolated elective nodal failure. Radiation volume adequacy did not seem to affect elective nodal failure.

title: Relation between elective nodal failure and irradiated volume in XXXX ( @entity3 ) treated with radiotherapy using conventional fields and doses.

answer: @entity3


abstract: UNASSIGNED: @entity10 , previously known as @entity5  - @entity11  , shares a 360  -kb region of chromosome  2q13 with members of IL  -1 systems. @entity10 encodes an anti  -inflammatory cytokine, IL  -36 receptor antagonist ( @entity10 ). In spite of @entity10 showing the highest homology to IL  -1 receptor ( @entity9 ) antagonist, it differs from the latter in aspects including its binding to IL  -lRrp2 but not to @entity9 . @entity10 is mainly expressed in epithelial cells and has important roles in inflammatory diseases. In the present study, @entity10 was identified in the genomes of 27  species, including @entity0 , @entity3 , @entity2 , @entity7 and dolphin. @entity0 @entity10 was mainly expressed in the eye, head and neck, fetal heart, lung, testis, cervix and placenta; furthermore, it was highly expressed in bladder and @entity8 . Furthermore, a total of 30  single nucleotide polymorphisms causing missense mutations were determined, which are considered to be the causes of various diseases, such as generalized @entity6 . In addition, the link between @entity10 and the prognosis of certain @entity1 types was revealed through meta  -analysis. Tumor  -associated transcriptional factors c  -Fos, activator protein  -1, @entity4 and nuclear factor  kB were found to bind to the upstream region in the @entity10 gene. This may indicate that @entity10 is involved in tumorigenesis and @entity1 progression through the regulation of @entity1  -associated transcriptional factors. The present study identified @entity10 in various species and investigated the associations between @entity10 and @entity1 prognosis, which would determine whether @entity10 drove the evolution of the various species with regard to tumorigenesis.

title: Integrative genomic analysis of interleukin  -36RN and its prognostic value in XXXX .

answer: @entity1


abstract: BACKGROUND: The aim of the study is to demonstrate the feasibility and the oncologic effectiveness of quadrantectomy plus sentinel node biopsy performed under local anesthesia, and to demonstrate the economic and psychologic advantages. METHODS: From October 1996 to March 2000, 71 @entity1 affected with clinical T1 N0 @entity0 , underwent quadrantectomy or @entity3 resection plus sentinel node biopsy and clinically suspicion axillary nodes biopsy, under local anesthesia at the @entity4 di Cura "Villa Mafalda" in Rome. RESULTS: Twenty @entity3 were T1a, 26 T1b e 25 T1c. A mean of 2 sentinel nodes (range 1-4) and a mean of 8 axillary nodes were removed during the procedure. In 2 cases sentinel nodes were not identified. Intraoperative histologic examination showed metastatic sentinel nodes in 11 cases. An axillary node dissection was performed in all cases (>12 nodes) and no other metastatic nodes were found. In all @entity1 clinically suspected nodes were removed. In two cases no evidence of @entity2 was found in sentinel nodes, while histologic examination revealed in a @entity1 micrometastasis in one node, and in another @entity1 two metastatic nodes. CONCLUSIONS: Fifty-three @entity1 rated the overall surgical, anesthetic and recovery experience as "very satisfactory", 13 "satisfactory" and 5 "unsatisfactory". @entity1 typically expressed their pleasure at the possibility to return home and stressed the ease of recovery.

title: [Ambulatory surgical treatment for XXXX ].

answer: @entity0


abstract: BACKGROUND: @entity5 has been identified as a risk factor for @entity3 ( @entity3 ). South Asians appear to have a high incidence of @entity3 , while East Asians have a very low incidence. HYPOTHESIS: The present study was undertaken because the relative association of plasma @entity4 levels (PH) with @entity3 in South Asians (SA = Indian, Pakistani, @entity6 Lankan) and East Asians (EA = Chinese, Japanese) is not known. METHODS: Fasting PH were drawn on all @entity0 with @entity3 of SA (age 62.4+/-1.1 years, 72 @entity0 , 14 @entity0 ) and EA (age 61.8+/-3.0 years, 13 @entity0 , 4 @entity0 ) descent. These were compared with PH available from Caucasian (CA) @entity0 (age 61.1+/-1.1 years, 89 @entity0 , 17 @entity0 ) with @entity3 . RESULTS: The PH in SA, EA, and CA @entity0 were 11.0+/-0.5, 7.6+/-0.5, and 10.8+/-0.6 micromol/l, respectively (p<0.001 between EA and SA/CA). Percentages of SA, EA, and CA with elevated PH (> 12.0 micromol/l) were 33.7, 5.9, and 28.2%, respectively. There were no significant differences in the lipid subfractions between the SA and EA group. History of smoking was significantly higher in the EA (52.9 vs. 26.2%), while @entity2 and @entity1 had similar prevalences. CONCLUSION: Significant differences in PH of SA versus EA @entity0 with @entity3 exist. The relative contribution of @entity4 in the development of @entity3 appears to be less in EA immigrants. In contrast, the association between @entity3 and PH in SA immigrants appears to be similar to that of Caucasians.

title: Possible ethnic differences in plasma @entity4 levels associated with XXXX between south Asian and east Asian immigrants.

answer: @entity3


abstract: @entity1 ( @entity1 ) is characterized by progressive death of @entity4 (DA) neurons in the substantia nigra pars compacta. We report a @entity0 model that exhibits progressive death of nigral neurons following unilateral injection of @entity7 in the striatum. In situ end-labeling revealed significant numbers of dying nigral neurons ipsilateral to the lesion during the first 3 weeks following injection. An indication of the gradual nature of death was that similar small numbers of cells were detected at each time point. These early morphological markers of @entity2 led to a significant reduction (20%) at 5 months of @entity3 hydroxylase-positive neurons and total number of neurons in the ipsilateral substantia nigra compared with the contralateral control. To examine the role of nigrostriatal DA metabolism in the observed nigral @entity2 , we manipulated DA metabolism during the initial 2 weeks following @entity7 lesion. Neurons in the ventral tier of the substantia nigra pars compacta were protected from death by treatment with @entity10 ( @entity11 ), an inhibitor of @entity5 cyclohydrolase, the initial enzyme in the synthesis of the @entity3 hydroxylase co-substrate, @entity8 ( @entity9 ). Neurons in both the dorsal and ventral tier of substantia nigra pars compacta were protected from death by treatment with DAHP and @entity6 . These experiments suggest that intrastriatal @entity7 lesion is an in vivo model of trophic support withdrawal. This experimental procedure is useful for studying mechanisms underlying protracted death of nigral DA neurons and may provide valuable mechanistic information relevant to understanding the etiology of @entity1 .

title: @entity7 lesion-induced nigral XXXX .

answer: @entity2


abstract: We report two cases of @entity6 paresthetica. The first @entity0 was 35-year-old pregnant @entity0 who reported dull @entity2 on the front and side of her thigh presenting at 6 weeks gestation. The symptoms disappeared in 1 week with conservative treatment and no other symptoms developed. The second @entity0 was a 56-year-old @entity0 , @entity1 , who reported intense, burning @entity2 with @entity4 and occasional bouts of piercing @entity2 . The symptoms were resistant to treatment with non-steroidal antiinflamatory drugs or mild opiates, but were relieved by injection of local anesthetics and @entity3 . @entity6 paresthetica is @entity5 that affects the lateral femoral cutaneous nerve. It can occur during pregnancy or in other contexts. The most common cause is entrapment of the nerve at the anterior superior iliac spine or during its passage through the inguinal ligament. The most common symptom is @entity4 at the front of the thigh, although burning, formication, tingling, or other forms of paresthesia may also be present. The condition is usually self-limiting, although uncomfortable. Diagnosis is based on careful neurological examination. Conservative treatment is preferred and is based on limiting periods of standing and avoidance of tight clothing. Oral analgesics can be prescribed if necessary and weight loss is required for @entity1 @entity0 . Surgical ablation of the nerve is a last resort.

title: [2 cases of paresthetic XXXX of the femoral cutaneous nerve].

answer: @entity6


abstract: UNASSIGNED: To determine the causes underlying the formation of adult @entity4 .Anomalous pancreaticobiliary junction is the most widely accepted theory regarding the etiology of @entity4 . However, @entity4 have been found in @entity0 in the absence of this @entity1 . Because the number of adult @entity0 with @entity4 is increasing, it is important to address this controversy.Bile amylase levels in the cysts of 27 @entity0 (8 males and 19 females) who had undergone cholecystectomy were retrospectively evaluated.The average age of the 27 @entity0 was 45.8  10.1 years and the majority (85.2%) were diagnosed with Todani type I cysts. None of the @entity0 had dilatation of the common bile duct prior to surgery. There were 6 (22.2%) @entity0 with @entity5 . However, amylase levels did not significantly differ between @entity0 with and without this @entity1 (P=0.251). According to bile amylase levels, @entity2 was present in 21 (77.8%) @entity0 . The mean amylase level significantly differed in @entity0 with @entity2 (23,462  11,510IU/L) and those without (235  103IU/L) (P<0.001). In @entity0 with @entity2 , only 4 @entity0 had @entity5 . That is, the majority of @entity0 (17/21, 81%) having @entity2 did not have an anomalous junction of the pancreatic and biliary ducts.Since the only explanation for @entity2 in @entity0 with a normal pancreaticobiliary junction is @entity3 , we proposed that the formation of adult @entity4 is mainly due to @entity3 .

title: XXXX and the Formation of Adult Choledochal Cyst Following Cholecystectomy: A Retrospective Cohort Study.

answer: @entity3


abstract: This study aimed at evaluating the possible effects of @entity1 ( @entity1 ) after shockwave lithotripsy (SWL) on the health-related quality of life (QOL) of the @entity0 on a size-related basis. Eighty six @entity0 with @entity1 after SWL were divided into three groups: Group 1 (n:30 with fragments  <=2  mm), Group 2 (n:21 2- <=4  mm) and Group 3 (n:35  >  4  mm). During a 3-month follow-up, spontaneous passage rates, emergency department visits, mean analgesic required, additional procedures and the QOL were all evaluated. QOL was evaluated using the Short Form-36 survey. Of the 30 @entity0 with fragments  <=2  mm all cases passed the fragments spontaneously. Of the 21 cases with fragments 2- <=4, however, 76  % were stone free. Last, of the 35 cases with fragments >4  mm, 52  % passed them spontaneously in 3  months. While no @entity0 with fragments  <=2  mm required emergency department visit, 19  % of the cases with fragments 2- <=4  mm and 51.4  % with fragments >4  mm did require this visit. Mean analgesic need (mg) values were higher in cases with larger fragments. Evaluation of the QOL score data in a subgroup comparison base showed that cases with larger fragments had prominently lower scores during both 1- and 3-month evaluation. @entity1 after SWL could pose an impact on the QOL of the cases in a size-related basis. While fragments  <=2  mm had nearly no impact on this aspect larger fragments could significantly affect the QOL.

title: How do the XXXX after SWL affect the health-related quality of life? A critical analysis in a size-based manner.

answer: @entity1


abstract: UNASSIGNED: Non- @entity7 antagonist oral anticoagulants (NOACs) are frequently used to prevent @entity1 in @entity0 with @entity4 . These @entity0 are often also on @entity2 or other antiplatelet agents. It is possible that treatment with both NOACs and @entity2 or other antiplatelet drug may be effective in decreasing @entity1 , but data are sparse regarding the efficacy and safety of using both agents for @entity1 prevention.To address these issues, data were pooled from the four recent randomized controlled trials of NOACs @entity10 , @entity8 , @entity9 and @entity11 , which included 42,411 @entity0 ; 14,148 (33.4%) were also on @entity2 or other antiplatelet drug. The number of @entity5 among @entity0 on @entity12 and @entity2 /antiplatelet was compared to the number of events in @entity0 on @entity12 alone. Bleeding rates were also compared among those on @entity12 + @entity2 /antiplatelet to @entity12 alone. These results were compared to @entity5 and @entity3 events in the @entity6 + @entity2 /antiplatelet vs. @entity6 alone. No greater risk for @entity5 was seen in @entity0 on NOACs compared to @entity0 on both NOACs and @entity2 /antiplatelet drug. In this non-randomized comparison, there was initially a signal towards higher @entity5 rates among @entity12 users also on @entity2 /antiplatelet drugs (RR 1.16; 95% CI 1.05, 1.29) compared to @entity12 alone. This likely reflected the higher CHADS2 scores of those on @entity2 /antiplatelet drugs. When the analysis was limited to studies that included @entity2 rather than other antiplatelet drugs, no difference was seen for @entity5 rates comparing dual therapy to @entity12 alone (RR 1.02; 95% CI 0.90, 1.15). Higher rates of @entity3 were seen with @entity2 /antiplatelet drug in conjunction with @entity12 . In this meta-analysis and nonrandomized comparison of @entity2 /antiplatelet users and nonusers also on anticoagulation, there was no additional benefit seen of anticoagulation and antiplatelet therapy for @entity1 4 prevention compared to anticoagulation alone. There was, however, an increased risk of @entity3 . Careful assessment of the indications for antiplatelet drugs in @entity0 with @entity4 who are also receiving oral anticoagulation is warranted, and future randomized comparisons are needed.

title: Non-VKA Oral Anticoagulants and Antiplatelet Therapy for @entity1 Prevention in @entity0 with XXXX : a Meta-analysis of Randomized Controlled Trials.

answer: @entity4


abstract: OBJECTIVE: The objective of this study is to investigate the occurrence of gastrointestinal (GI) and extraintestinal symptoms in @entity0 and adolescents with @entity1 ( @entity5 ) and @entity3 ( @entity3 ) and their association with specific antibodies and histopathology of @entity4 ( @entity4 ), representing its clinical forms in the iceberg. MATERIAL AND METHODS: Cross-sectional study (November 2009-December 2012) conducted at an outpatient care facility in Northeast Brazil including @entity0 [ @entity5 (n   =   111); @entity3 (n   =   77)] aged 10 months-18 years old. Measurement of anti-endomysial (EmA) and anti-tissue transglutaminase (anti-tTG) IgA antibodies was performed, as was that of anti-tTG-IgG in the cases with low serum IgA. The patients with antibody positivity were subjected to small intestine biopsy. RESULTS: @entity2 occurred in 53.7% of the sample, extraintestinal symptoms in 4.3%, and antibody positivity in 28.2% (n   =   53). Of those who underwent biopsy (n   =   40), histopathological findings of @entity4 were found in 37.5% [ @entity5   =   5/111 (4.5%), @entity3   =   10/77 (13.0%)]. @entity2 were associated with antibody positivity, but not with the histopathology. The GI (32.5%), silent (5.0%), and potential (62.5%) forms of disease were detected. CONCLUSIONS: The prevalence of @entity2 was high in groups @entity5 and @entity3 , and the occurrence of such symptoms was associated with antibody positivity. The lack of association between the symptoms and histopatholological findings points to the inconsistency of the former as indicators of @entity4 . Although the GI form predominated among the cases with active @entity4 , its contribution to the celiac iceberg was smaller compared with the potential form, which determined the large and submerged base of the iceberg representing the high-risk groups investigated.

title: The celiac iceberg: from the clinical spectrum to serology and histopathology in @entity0 and adolescents with XXXX and @entity3 .

answer: @entity1


abstract: PURPOSE: To delineate the electroclinical features of @entity0 with partial @entity3 in adolescence with a benign outcome. METHODS: @entity0 were recruited in five different Italian @entity2 centers. @entity0 were selected among those with partial @entity3 between ages 11 and 17 years. We excluded benign childhood @entity2 , those with @entity1 , and those with neuroradiologically documented lesions. We also excluded @entity0 with less than 3 years' follow-up or who were still receiving antiepileptic therapy. RESULTS: There were 37 (22 male, 15 female) @entity0 . @entity3 started at the mean age of 14.5 years (range, 11-16.11). Two main electroclinical patterns emerged: 16 of 37 @entity0 had somatomotor @entity3 frequently associated with focal theta discharges involving the centroparietal regions. Ten of 37 @entity0 showed versive @entity3 and interictal spiking involving the posterior regions. A third group had clinical characteristics resembling the cases described by Loiseau. All had a favorable outcome. CONCLUSIONS: This relevant multicenter study further confirms the existence of benign @entity2 with onset during adolescence.

title: Benign XXXX of adolescence: a report of 37 new cases.

answer: @entity2


abstract: UNASSIGNED: @entity1 with an increased lifetime risk of @entity3 are advised to undergo risk-reducing salpingo-oophorectomy (RRSO) to reduce risk of @entity2 . We investigated the uptake of RRSO and evaluated the influence of personal medical history of (breast) @entity2 , risk-reducing mastectomy (RRM) and family history of @entity6 on the RRSO decision. This single center retrospective observational cohort study was performed in a tertiary multidisciplinary clinic for @entity5 of the University Medical Centre Utrecht, the Netherlands. @entity1 >= 35  years old with an estimated lifetime risk of @entity3 >= 10  %, who had completed childbearing, were eligible for RRSO. Uptake and timing of RRSO were analyzed. Influence of personal medical history and family history on RRSO decision making, were evaluated with logistic regression. The study population consisted of 218 @entity1 (45.0  % @entity7 mutation carrier, 28.0  % @entity4 mutation carrier, 27.0  % with familial susceptibility) with 87.2  % RRSO uptake. The median age at RRSO was 44.5 (range 28-73) years. Of the @entity1 undergoing RRSO, 78.3  % needed  <=3 consultations to reach this decision. Multivariable analysis showed a significant difference in RRSO uptake for @entity1 with a history of RRM [OR 3.66 95  % CI (1.12-11.98)], but no significant difference in @entity1 with a history of @entity0 [OR 1.38 95  % CI (0.50-3.79)], nor with a family history of @entity6 [OR 1.10 95  % CI (0.44-2.76)]. We conclude that RRSO counseling, without the alternative of screening, is effective. The uptake is increased in @entity1 with a history of RRM.

title: The effect of personal medical history and family history of XXXX on the uptake of risk-reducing salpingo-oophorectomy.

answer: @entity2


abstract: @entity5 are one of the most serious complications of @entity11 but the mechanism underlying @entity5 is unclear. We reported the cytokine levels in a cerebral @entity13 in a @entity0 with @entity9 . The @entity0 was a 12-year-old female. She was diagnosed as having @entity9 and @entity1 consisting of an @entity12 at birth. She underwent a radical operation at 9 years but mitral @entity3 remained. She was hospitalized with high fever, @entity4 , loss of activity and gait disturbance. Neurological examination revealed @entity10 and @entity8 on the left side. Cytokines such as @entity7 , @entity2 , sTNFR1 and sE-selectin were elevated in blood, and @entity7 , @entity2 and sTNFR1 in cerebrospinal fluid. T2-weighted MRI disclosed a low intensity area in the right Sylvian sulcus. MR angiography showed an @entity6 of the right middle cerebral artery. We think that cytokines and the formation abnormality of collagen fibers are related to the production of @entity6 .

title: Increased cytokine levels in a cerebral @entity13 in a @entity0 with XXXX .

answer: @entity9


abstract: BACKGROUND AND PURPOSE: Enhancing @entity4 clearance through phagocytosis may reduce @entity6 after @entity7 . In the current study, we investigated the role of cluster of differentiation 47 (CD47) in regulating erythrophagocytosis and @entity6 after @entity7 in @entity1 . METHODS: This study was in 2 parts. First, male adult @entity1 had an intracaudate injection of 30  L saline, blood from male adult @entity3 ( @entity3 ) @entity1 , or blood from CD47 knockout @entity1 . Second, @entity1 had an intracaudate injection of 30  L CD47 knockout blood with @entity8 or control liposomes. @entity8 liposomes were also tested in saline-injected @entity1 . All @entity1 then had magnetic resonance imaging to measure @entity4 size and @entity0 . Brains were used for immunohistochemistry and Western blot. RESULTS: Erythrophagocytosis occurred in and around the @entity4 . Injection of CD47 knockout blood resulted in quicker clot resolution, less @entity0 , and less @entity2 compared with @entity3 blood. Higher brain @entity5 oxygenase-1 levels and more microglial activation (mostly M2 polarized microglia) at day 3 were found after CD47 knockout blood injection. Co-injection of @entity8 liposomes, to deplete phagocytes, caused more severe @entity0 and less clot resolution. CONCLUSIONS: These results indicated that CD47 has a key role in @entity4 clearance after @entity7 .

title: Role of Erythrocyte CD47 in Intracerebral XXXX Clearance.

answer: @entity4


abstract: PURPOSE: @entity8 , a recombinant @entity6 , has been used in the treatment of acute @entity7 . Experience is accumulating regarding its use in the treatment of @entity5 . Increased experience with this thrombolytic agent may show that it can be an appropriate alternative agent to currently employed plasminogen activators. MATERIALS AND METHODS: Over the course of six months, @entity8 was used to treat 18 @entity0 with peripheral @entity2 , confined to the lower extremities. The agent was infused via "pulse-spray" catheters. Fifteen @entity0 were started on 0.5 U/h. Concurrent heparin therapy was used at 500 U/h in 16 of 18 @entity0 . RESULTS: The average total dose of @entity8 infused was 13.3 units. It ranged from 6.2 to 41.5 units. The average duration of infusion was 26.9 hours with a range of 12-44 hours. Clinical success, defined as restoration of sufficient patency to reestablish limb function and resolution of @entity1 in the symptomatic extremity was 89% (16 out of 18). @entity3 occurred in five @entity0 and were major in one @entity0 (5%). No @entity0 experienced @entity4 . CONCLUSION: Increased experience with the use of @entity8 in the treatment of @entity2 is accumulating. The safety and efficacy profile in our group appears satisfactory and compares to other studies. However, definite conclusions must await the results of controlled comparisons of different @entity8 infusion regimens and controlled comparison to other thrombolytic agents.

title: @entity8 infusion in the treatment of XXXX .

answer: @entity2


abstract: @entity3 isolates were recovered from the National Antimicrobial Resistance Monitoring System retail meat program and examined for antimicrobial susceptibility. Retail meat samples (n = 11,921) from four U.S. states collected during 2002 to 2008, consisting of 2,988 @entity8 breast, 2,942 ground @entity2 , 2,991 ground beef, and 3,000 pork chop samples, were analyzed. A total of 8,286 @entity3 isolates were recovered. The greatest numbers of samples contaminated with the organism were @entity8 (83.5%) and @entity2 (82.0%), followed by beef (68.9%) and pork (44.0%). Resistance was most common to @entity6 (50.3%), followed by @entity13 (34.6%), @entity1 - @entity18 (31.6%), @entity7 (22.5%), @entity4 (18.6%), @entity15 (8.4%), @entity16 (6.4%), and @entity12 (5.2%). Less than 5% of the isolates had resistance to @entity0 , @entity11 , @entity17 , @entity5 , @entity10 , and @entity9 . All isolates were susceptible to @entity14 . Compared to beef and pork isolates, the poultry meat isolates had a greater percentage of resistance to all tested drugs, with the exception of @entity10 , to which pork isolates had the most resistance. More than half of the @entity2 isolates (56%) were resistant to multidrugs (>= 3 classes) compared to 38.9% of @entity8 , 17.3% of pork, and 9.3% of beef isolates. The bla(CMY) gene was present in all @entity11 - and @entity17 -resistant isolates. The cmlA, flo, and catI genes were present in 45%, 43%, and 40% of @entity10 -resistant isolates, respectively. Most @entity5 -resistant isolates (98.5%) had a gyrA mutation in S83 or D87 or both, whereas only 6.7% had a parC mutation in either S80 or E84. The results showed that @entity3 was commonly present in the retail meats, and antimicrobial resistance profiles differed according to the animal origin of the isolates.

title: Comparison of the prevalences and antimicrobial resistances of XXXX isolates from different retail meats in the United States, 2002 to 2008.

answer: @entity3


abstract: BACKGROUND: A chief morbidity of @entity2 is ocular exposure, which is largely due to lower lid retraction and ectropion. OBJECTIVE: To assess the role of midfacial elevation in the comprehensive surgical treatment of @entity5 lower lid malposition and ocular exposure. METHODS: Eleven @entity0 with chronic @entity2 causing symptomatic ocular exposure were treated with subperiosteal midface elevation as a component of comprehensive lower lid elevation. Other procedures were performed concomitantly to treat lower lid ligament laxity and reduced lower @entity1 , as required. Preoperative and postoperative ocular exposure symptoms, visual acuity, lower lid position, lagophthalmos, and @entity3 were compared. RESULTS: At an average of 17 months of follow-up, all @entity0 reported improvement in symptoms. Visual acuity was maintained or improved in all @entity0 . Lower eyelid position (P =.003), lagophthalmos (P =.07), and @entity3 (P<.001) were also improved. CONCLUSIONS: Midfacial elevation is a safe and effective surgical adjunct in the treatment of lower eyelid retraction in chronic @entity4 . Its use reduces the need for tarsorrhaphy, which limits the binocular visual field and negatively impacts cosmesis.

title: Comprehensive midfacial elevation for ocular complications of XXXX .

answer: @entity2


abstract: OBJECTIVE: To analyze the association between @entity1 and @entity6 . METHODS: We reviewed five cases of @entity1 that ruptured, producing acute @entity6 . The surgical management and diagnostic methods used are assessed. RESULTS: Five male @entity0 ranging in age from 6 to 25 years sustained the rupture of @entity1 , which produced acute @entity6 . Four of the @entity0 had incurred blunt @entity4 . All @entity0 presented with symptoms referable to @entity3 . The pathognomonic features of a middle fossa @entity1 (MFAC) were noted on the computed tomographic scans and/or magnetic resonance images of each @entity0 . The @entity5 exerted mass effect on the ipsilateral hemisphere and was noted to be under significant pressure at the time of surgical intervention in each case. Two of the five cases are unique in the literature. In one, a coexisting quadrigeminal cyst ruptured, producing a @entity6 ipsilateral to the MFAC and dilating the basal cisterns. In the other, the MFAC ruptured into the basal cisterns as well as into the subdural space. The MFAC in each of the remaining three @entity0 ruptured into the subdural space alone. All @entity0 were treated with drainage of the subdural space. In the two @entity0 in whom the basal cisterns were involved, both the @entity5 and the MFACs failed to change significantly in size. The @entity5 resolved completely and the MFACs decreased in size considerably in the three @entity0 without cisternal involvement. CONCLUSION: The rupture of an @entity1 can produce a @entity6 and @entity3 . The latter mandates emergent drainage of the subdural space. In @entity0 in whom the basal cisterns are not dilated by @entity2 , both the MFACs and @entity5 resolve after subdural drainage.

title: @entity1 rupture producing XXXX and @entity3 : case reports.

answer: @entity6


abstract: UNASSIGNED: Clinical studies of @entity0 with @entity4 and prospective studies of childhood @entity1 survivors show inconsistent findings regarding the relationship between childhood @entity1 and dissociation. This study aims to resolve this inconsistency by investigating how dissociation is related to @entity3 , general psychopathology, childhood @entity1 , and adulthood @entity1 . Specifically, we focus on the role of cumulative traumatization in pathological and non-taxon dissociation. Eighty acute @entity2 inpatients were administrated standardized measures on dissociation, perceived @entity3 , traumatizing events, and general psychopathology. @entity3 and @entity1 correlated with both types of dissociation and general psychopathology. When general psychopathology and @entity3 were controlled, a unique link between @entity1 and dissociation remained significant. Moreover, the pattern of relationships differed for non-taxon and pathological dissociations. The effect of childhood but not adulthood @entity1 was significant on non-taxon dissociation. In contrast, an interactive model incorporating both childhood and adulthood @entity1 was the best model for explaining pathological dissociation. Childhood @entity1 is important for developing non-taxon dissociation, and adulthood @entity1 exacerbates its effects on the emergence of pathological dissociation. Cumulative traumatization from childhood to adulthood should be incorporated into the @entity1 hypothesis of pathological dissociation.

title: Cumulative traumatization associated with pathological dissociation in acute XXXX inpatients.

answer: @entity2


abstract: UNASSIGNED: Close to three percent of the world's population suffer from @entity1 . Despite the range of treatment options available for @entity1 @entity0 , not all @entity0 benefit from them. Investigating how different pathways correlate with phenotype of interest may help unravel novel drug targets and discover a possible cure. Many pathway-based methods have been developed to incorporate biological knowledge into the study of microarray data. Most of these methods can only analyze individual pathways but cannot deal with two or more pathways in a model based framework. This represents a serious limitation because, like genes, individual pathways do not work in isolation, and joint modeling may enable researchers to uncover patterns not seen in individual pathway-based analysis. In this paper, we propose a random effects model to analyze two or more pathways. We also derive score test statistics for significance of pathway effects. We apply our method to a microarray study of @entity2 . Our method may eludicate how pathways crosstalk with each other and facilitate the investigation of pathway crosstalks. Further hypothesis on the biological mechanisms underlying the disease and traits of interest may be generated and tested based on this method.

title: Random Effects Model for Multiple Pathway Analysis with Applications to XXXX .

answer: @entity2


abstract: INTRODUCTION: 131I-CLR1404 is a small molecule that combines a tumor-targeting moiety with a therapeutic radioisotope. The primary aim of this phase 1 study was to determine the administered radioactivity expected to deliver 400 @entity2 to the bone marrow. The secondary aims were to determine the pharmacokinetic (PK) and safety profiles of 131I-CLR1404. METHODS: Eight subjects with refractory or relapsed advanced solid @entity1 were treated with a single injection of 370 MBq of 131I-CLR1404. Whole body planar nuclear medicine scans were performed at 15-35 minutes, 4-6, 18-24, 48, 72, 144 hours, and 14 days post injection. Optional single photon emission computed tomography imaging was performed on two @entity0 6 days post injection. Clinical laboratory parameters were evaluated in blood and urine. Plasma PK was evaluated on 127I-CLR1404 mass measurements. To evaluate renal clearance of 131I-CLR1404, urine was collected for 14 days post injection. Absorbed dose estimates for target organs were determined using the RADAR method with OLINDA/EXM software. RESULTS: Single administrations of 370 MBq of 131I-CLR1404 were well tolerated by all subjects. No severe adverse events were reported and no adverse event was dose-limiting. Plasma 127I-CLR1404 concentrations declined in a bi-exponential manner with a mean t   value of 822 hours. Mean Cmax and AUC(0-t) values were 72.2 ng/mL and 15753 ng   hr/mL, respectively. An administered activity of approximately 740 MBq is predicted to deliver 400 @entity2 to marrow. CONCLUSIONS: Preliminary data suggest that 131I-CLR1404 is well tolerated and may have unique potential as an anti- @entity1 agent. TRIAL REGISTRATION: ClinicalTrials.gov NCT00925275.

title: A Phase 1 Study of 131I-CLR1404 in @entity0 with Relapsed or Refractory Advanced XXXX : Dosimetry, Biodistribution, Pharmacokinetics, and Safety.

answer: @entity1


abstract: Synchronized neural activity is believed to be essential for many CNS functions, including neuronal development, sensory perception, and memory formation. In several brain areas @entity2 (A) receptor-mediated synaptic inhibition is thought to be important for the generation of synchronous network activity. We have used @entity2 (A) receptor @entity5 subunit deficient @entity0 ( @entity5 -/-) to study the role of GABAergic inhibition in the generation of network oscillations in the olfactory bulb (OB) and to reveal the role of such oscillations in olfaction. The expression of functional @entity2 (A) receptors was drastically reduced (>93%) in @entity5 -/- granule cells, the local inhibitory interneurons of the OB. This was revealed by a large reduction of @entity4 -evoked whole-cell current and the total current mediated by spontaneous, miniature inhibitory postsynaptic currents (mIPSCs). In @entity5 -/- mitral/tufted cells (principal cells), there was a two-fold increase in mIPSC amplitudes without any significant change in their kinetics or frequency. In parallel with the altered inhibition, there was a significant increase in the amplitude of theta (80% increase) and gamma (178% increase) frequency oscillations in @entity5 -/- OBs recorded in vivo from freely moving @entity0 . In odor discrimination tests, we found @entity5 -/- @entity0 to be initially the same as, but better with experience than @entity5 +/+ @entity0 in distinguishing closely related monomolecular @entity3 . However, @entity5 -/- @entity0 were initially better and then worse with practice than control @entity0 in distinguishing closely related mixtures of @entity3 . Our results indicate that the disruption of @entity2 (A) receptor-mediated synaptic inhibition of GABAergic interneurons and the augmentation of IPSCs in principal cells result in @entity1 in the OB with complex effects on olfactory discrimination, which can be explained by an increase in the size or effective power of oscillating neural cell assemblies among the mitral cells of @entity5 -/- @entity0 .

title: Disruption of XXXX (A) receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network.

answer: @entity2


abstract: BACKGROUND: In this study we built a time series model in the time domain based on the cases of @entity1 declared every four weeks in Spain between 1972 and 1998 With the model we analyzed the incidence of the disease and examined whether an epidemic really took place at the beginning of 1997, or whether the values were in the range of expectations. At this time there was widespread social alarm in Spain, because there was considered to be an outbreak of @entity0 . We also examined whether the incidence of the disease diminished during 1997 following the measures introduced by the Comisi  n Interterritorial del Sistema Nacional de Salud. METHOD: The data on the incidence of the @entity1 in Spain were obtained from the Bolet  n Epidemiol  gico Semanal, published by the Instituto de Salud Carlos III, declared from 1972 to 1998 and grouped every four weeks. The method corresponds to the time series model in the domain of time: the Box-Jenkins method. RESULTS: In order to explain the behaviour of the disease during the years of the study we chose a model ARIMA(0,1,1) (0,1,1)13 that shows @entity2 , with higher incidence in the winter and the beginning of spring, and lower incidence in summer. An intervention analysis showed that in March 1996 there was a level shift in the incidence of the illness. This lasted until September 1997, at which time the incidence returned to pre-1996. CONCLUSIONS: The measures of sanitary monitoring against the @entity0 in the months of greater incidence, winter and beginning of spring must be intensified. Between spring 1996 and autumn 1997 the incidence of @entity0 increased. Thereafter, until the end of 1998, there was a significant decrease in incidence, attributable to the performance of the health authorities.

title: [ XXXX in Spain: seasonal nature and recent changes].

answer: @entity1


abstract: STUDY DESIGN: Clinical study of percutaneous endoscopic surgery for cervical @entity6 (CHIVD). OBJECTIVES: Our aim was to evaluate the efficacy of anterior percutaneous @entity9 (APECD), previously known as percutaneous @entity9 , for CHIVD. In addition, the ways to avoid major complications, including case selection and surgical techniques, are highlighted. SUMMARY OF BACKGROUND DATA: CHIVD is a common disease and can cause @entity5 , namely, radiating @entity2 , @entity7 or @entity3 , or @entity4 . If conservative treatment failed, most @entity0 were treated by anterior cervical discectomy and fusion. METHODS: From October 2002 to July 2008, a total of 107 consecutive @entity0 with clinically symptomatic CHIVD who underwent APECD were enrolled. The clinical outcomes were evaluated using the visual analog scale, Neck Disability Index, and modified MacNab criteria. Radiographic follow-up included static and dynamic plain cervical radiographs and magnetic resonance imaging. RESULTS: Eighty-six @entity0 (80%) could be followed up for at least 12 months (range: 12 to 60 mo; mean, 22.4 mo) for outcome evaluation. The visual analog scale and Neck Disability Index improved significantly (P<0.001) after the operation. According to the modified MacNab criteria, excellent and good outcome were achieved in 29 (34%) and 49 (57%) @entity0 , respectively. Two @entity0 (2 of 107, 2%) experienced operation-related complications: 1 @entity0 sustained @entity8 and was treated with angiographic stenting, whereas the other @entity0 had @entity1 and recovered after conservative treatment. CONCLUSIONS: APECD is not only minimally invasive but can also avoid the morbidities of conventional open cervical discectomy. @entity0 have a more rapid postoperative recuperation. Nevertheless, it carries the risk of major complications. With careful @entity0 selection and use of meticulous surgical techniques, it is still a safe and effective alternative to open surgical modalities for CHIVD.

title: Anterior percutaneous @entity9 for cervical XXXX : outcome, complications, and technique.

answer: @entity6


abstract: OBJECTIVES: Several studies have shown increased atherogenic risk factors and biomarkers of @entity1 and @entity2 in association with growth hormone excess. Mean platelet volume ( @entity5 ) and red blood cell distribution (RDW) are currently gaining interest as new independent cardiovascular risk factors. The aim of this study was to evaluate the effect of disease control on @entity5 and RDW in @entity4 @entity0 . MATERIALS AND METHODS: We retrospectively enrolled 36 @entity4 @entity0 (23 males, 13 females; mean age 41.94    11.55). @entity0 were divided into two groups: disease controlled by surgical treatment alone (group A) or by @entity3 analog (SSA) therapy (group B). @entity5 and RDW measurements were evaluated during active and inactive disease periods in the two groups. RESULTS: There were statistically significant increases in @entity5 and RDW in @entity0 receiving SSA therapy (P = 0.012 and P = 0.020, respectively). The differences in @entity5 and RDW changes in @entity0 receiving surgical treatment alone were not statistically significant (P=0.364 and P=0.339, respectively). CONCLUSIONS: This is the first report on the evaluated the effect of disease control on @entity5 and RDW in @entity4 @entity0 . Our study results showed that @entity5 and RDW measurements are significantly increased in @entity4 @entity0 with disease controlled by SSA therapy. Therefore, acromegalic @entity0 treated with SSAs may have increased cardiovascular risk based on an increase in @entity5 and RDW.

title: The effect of disease control on mean platelet volume and red blood cell distribution in @entity0 with XXXX .

answer: @entity4


abstract: BACKGROUND: International recommendations suggest considering home treatment or early hospital discharge in low risk mortality @entity1 ( @entity1 ). Direct oral anticoagulants (DOACs) may offer several advantages in the management of acute @entity1 . The aim of the present study was to focus on trends in length of hospital stay (LOS) over the years and on the burden of DOACs on this endpoint in @entity0 suffering from acute @entity1 . MATERIALS AND METHODS: We retrospectively analyzed data of @entity0 discharged from five hospitals of the Florence district, Italy, searching for International Classification of Disease 9th revision Clinical Modification (ICD-9CM) codes 415.11 or 415.19 in hospital discharge schedule in the years 2010, 2012 and from 2014 January, 1st to 2015 August 31st. @entity0 who died during hospital stay were excluded from analysis on LOS. In the survivors from one of the five hospitals, we also focused on anticoagulants prescribed at hospital discharge according to early mortality risk assessment by using the new 2014 European Society of Cardiology (ESC) prognostic model. RESULTS: Over the years, @entity0 discharged for @entity1 have reduced in number. Despite a trend in reduction, mean and median LOS have not significantly decreased over the years. A very small percentage (3%) of @entity0 received an ultra-early discharge from hospitals within 48 hours from admission, whereas the percentage of @entity0 who were discharged within 6 days increased from 26.6% to 31.5%. In 2014 and 2015, 36.7% of @entity0 with diagnosis of acute @entity1 were discharged on low molecular weight heparins or fondaparinux, 32.5% of @entity0 were discharged on @entity2 antagonists and 30.4% of @entity0 on DOACs. DOACs prescription increased from 23.2% in 2014 to 40.1% in 2015. Mean and median LOS in @entity0 on DOACs were significantly lower than in @entity0 on other anticoagulant treatments. DOACs were prescribed in 40% of high risk, 68.1% of intermediate-high risk, 40.4% of intermediate-low risk and finally in 83.3% of low risk @entity0 ; 28% of @entity0 received DOACs within 48-hours from diagnosis and 64% received DOACs within 96 hours from diagnosis. Median timing for starting DOACs from diagnosis was 4 days (IQR 2-5). In @entity0 receiving DOACs, median LOS was 6 days (IQR 5-7) in low risk @entity0 compared with 8 days (IQR 7-9) in non low (intermediate/high) risk @entity0 . Median LOS after DOACs prescription was 5 days (IQR 1-6). CONCLUSION: In Florence district, early discharges and LOS in @entity0 with acute @entity1 have not significantly changed over the years. Due to a significant LOS reduction in @entity0 , prescribing DOACs hospital costs could be dramatically saved. Further prospective investigations are absolutely warranted to clarify these points.

title: Trends in length of hospital stay in XXXX over the years. What is changing in the era of direct oral anticoagulants?

answer: @entity1


abstract: BACKGROUND: Currently, only trastuzumab, ramucirumab, and @entity6 effectively treat @entity3 . Thus, additional novel targets are required for this disease. METHODS: We investigated the immunohistochemical and fluorescence in situ hybridization expression of MET, @entity7 , and @entity4 in four gastric cell lines and a cohort of 98 @entity3 @entity0 . @entity5 response was studied in vitro and in vivo. RESULTS: @entity5 potently inhibited in vitro cell growth in only one cell line, which also showed MET amplification. A positive correlation between @entity5 sensitivity and MET overexpression was observed (P  =  0.045) in the histoculture drug response assay. Meanwhile, @entity0 -derived @entity1 xenograft @entity2 models transplanted with tissues with higher MET protein expression displayed a highly selective sensitivity to @entity5 . In the 98 @entity0 , MET overexpression was found in 42 (42.9  %) and MET was amplified in 4 (4.1  %). @entity7 and @entity4 overexpression were found in 25 (25.5  %) and 0 @entity0 , respectively. However, none of the @entity0 screened harbored @entity4 or @entity7 rearrangements. No significant association was found between overall survival and MET or @entity7 status. We also observed a stage IV @entity3 @entity0 with MET amplification who experienced @entity1 shrinkage and clinical benefit after 3  weeks of @entity5 as fourth-line treatment. CONCLUSIONS: @entity5 may induce clinically relevant anticancer effects in MET-overexpressed or MET-amplified @entity3 @entity0 .

title: MET overexpression and amplification define a distinct molecular subgroup for targeted therapies in XXXX .

answer: @entity3


abstract: BACKGROUND: We previously demonstrated the efficacy of single-dose 6-monthly rituximab infusions in 25 adults with @entity4 -dependent minimal-change @entity6 . Herein, we assessed the safety of rituximab treatment and its effect in ameliorating the adverse effects of @entity5 ( @entity7 ) in a larger study sample. METHODS: We treated 54 adult @entity0 with four single-dose 6-monthly infusions of rituximab (375 mg/m(2) BSA per dose). We compared the adverse effects of @entity7 ( @entity3 , @entity2 , and @entity1 ) between the first rituximab infusion (baseline) and the end of the 24-month observation period. In addition, we examined the adverse effects of rituximab during the same period. RESULTS: The @entity7 dose was significantly lower at 24 months than at the baseline. The bone density was significantly higher at 24 months as compared to the baseline value (Z score -1.8 vs. -1.1; p < 0.05). Blood pressure at 24 months was significantly lower than that at the baseline (120.9/74.4 vs. 111.8/70.3 mm Hg; p < 0.05). Eight @entity0 with @entity1 showed improved glycemic control at 24 months as compared to that at the baseline. There were no severe adverse effects of rituximab. However, mild infusion reactions occurred in 31 @entity0 (57%). The frequency of the infusion reactions decreased significantly with every successive infusion. CONCLUSION: Rituximab treatment was effective and safe in @entity0 with @entity4 -dependent @entity6 , allowed reduction of the @entity7 dose, and ameliorated the adverse effects of @entity7 . It may be preferentially used in @entity0 at a risk of the adverse effect of @entity7 .

title: Amelioration of the adverse effects of XXXX by rituximab treatment in adults with @entity4 -dependent minimal-change @entity6 .

answer: @entity5


abstract: Irreversible electroporation (IRE) is a promising cell membrane ablative modality for @entity4 . There have been recent concerns regarding local recurrence and the potential use of IRE as a debulking (partial ablation) modality. We hypothesize that incomplete ablation leads to early recurrence and a more aggressive biology. We created the first ever heterotopic @entity2 model by inoculating BALB/c @entity2 in the hindlimb with a subcutaneous injection of Panc-1 cells, an immortalized @entity0 @entity4 cell line. Tumors were allowed to grow from 0.75 to 1.5   cm and then treated with the goal of complete ablation or partial ablation using standard IRE settings. Animals were recovered and survived for 2 days (n = 6), 7 (n = 6), 14 (n = 6), 21 (n = 6), 30 (n = 8), and 60 (n = 8) days. All 40 animals/ @entity1 underwent successful IRE under general anesthesia with @entity5 . The mean @entity1 volume of the animals undergoing ablation was 1,447.6   mm(3)    884). Histologically, in the 14-, 21-, 30-, and 60-day survival groups the entire @entity1 was nonviable, with a persistent @entity1 nodule completely replaced @entity3 . In the group treated with partial ablation, incomplete electroporation/recurrences (N = 10 animals) were seen, of which 66% had confluent @entity1 and this was a significant predictor of recurrence (P < 0.001). Recurrent @entity1 were also significantly larger (mean 4,578   mm(3)    SD 877 versus completed electroporated @entity1 925.8        277, P < 0.001). Recurrent @entity1 had a steeper growth curve (slope = 0.73) compared with @entity1 (0.60, P = 0.02). Recurrent @entity1 also had a significantly higher percentage of @entity6 expression, suggestive of stem cell activation. Tumors that recur after incomplete electroporation demonstrate a biologically aggressive @entity1 that could be more resistant to standard of care chemotherapy. Clinical correlation of this data is limited, but should be considered when IRE of @entity4 is being considered.

title: Efficacy of irreversible electroporation in XXXX @entity4 : advanced @entity2 model.

answer: @entity0


abstract: UNASSIGNED: Gene alterations are a well-established mechanism leading to drug resistance in @entity1 cells. A full understanding of the mechanisms of drug resistance in these cells will facilitate more effective chemotherapy. In this study, we investigated the mechanism(s) of drug resistance in the @entity0 @entity1 cell line MOLT-3 and its @entity3 -resistant derivative MOLT-3/IDR through complete mitochondrial and nuclear DNA analyses. We identified genetic differences between these two cell lines. The ND3 mutation site ( @entity5 ) in the mitochondrial DNA sequence was unique to MOLT-3/IDR cells. Moreover, we identified five candidate genes harboring genetic alterations, including @entity4 , via CGH array analysis. Sequencing of the @entity4 exon revealed a @entity6 mutation present within the stop codon in MOLT-3/IDR cells but absent from MOLT-3 cells. This mutation led to an additional 18 @entity2 in the protein encoded by @entity4 . Using real-time PCR, we determined an expression value for this gene of 0.35. Protein structure predictions confirmed a structural change in @entity4 in MOLT-3/IDR cells that corresponded to the site of the mutation. We speculate that this mutation may be related to @entity3 resistance.

title: Analysis to Estimate Genetic Variations in the XXXX -Resistant Derivative MOLT-3.

answer: @entity3


abstract: Between 1994 and 2001, triceps to biceps transfers were done in 10 @entity0 and a transfer of the forearm flexors and extensors (Steindler procedure) in nine. All had suffered from a post-traumatic lesion of their brachial plexus, resulting in @entity2 . Their mean age at the time of the original accident was 27 years (range 16-50 years) and at the time of muscle transfer 35 years (range 22-56 years), with a mean observation period of 20 months (range 6-51 months). In 16 @entity0 , a neurosurgical procedure had been performed after the @entity1 , and in 22 @entity0 other reconstructive operations had been done. Transfer of the forearm flexors and extensors resulted in active @entity4 with a mean of 94 degrees (range 70-130 degrees ). After triceps to biceps transposition a mean of 109 degrees (range 70-140 degrees ) was reached. A mean deficit of passive extension of 12 degrees (range 0-30 degrees ) remained after the Steindler procedure, and of 5 degrees (range 0-10 degrees ) after triceps to biceps transposition. Two complications occurred with the Steindler procedure. The transfer of the triceps muscle to the @entity3 or extensors on @entity2 , therefore, resulted in adequate movement and strength. Both procedures involve operating close to the elbow joint and had minimal complications. The triceps to biceps transfer is particularly suitable for co-contraction of triceps and biceps.

title: Transposition of local muscles to restore XXXX in brachial plexus palsy.

answer: @entity4


abstract: PURPOSE: The spread of @entity2 ( @entity2 ) affects both staging and treatment. In this prospective study we examined the relationship between @entity4 ( @entity4 ) levels in bile, mesenteric venous blood, and peripheral venous blood, and the presence of occult hepatic @entity1 in @entity0 with @entity2 . METHODS: Sixty @entity0 who underwent elective surgery at Ankara Oncology Hospital were voluntarily assigned to one of the three groups of 20 @entity0 each. The control group consisted of @entity0 operated on for @entity3 , the second group consisted of @entity0 with @entity2 without @entity1 , and the third group consisted of @entity0 with @entity2 and isolated liver @entity1 . Bile, mesenteric venous blood, and peripheral venous blood was collected perioperatively for the measurement of @entity4 levels. RESULTS: The bile @entity4 levels were significantly higher in the @entity2 @entity0 with @entity1 than in those without @entity1 and the controls. The @entity4 levels in the mesenteric venous blood and peripheral venous blood were significantly higher in the two groups of @entity2 @entity0 than in the control group. Overt hepatic @entity1 later developed in seven @entity0 from the @entity2 without @entity1 group who had relatively high @entity4 levels, but the difference was not significant. CONCLUSION: The @entity4 levels in bile, mesenteric venous blood, and peripheral venous blood were increased in @entity0 with @entity2 and liver @entity1 . The detection of elevated @entity4 levels in bile taken at surgery did not herald metachronous hepatic @entity1 in @entity2 @entity0 without liver @entity1 .

title: @entity4 to detect hepatic XXXX of @entity2 .

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to determine which characteristics could better distinguish @entity8 ( @entity8 ) from @entity6 ( @entity6 ) at the @entity3 ( @entity3 ) stage, with particular emphasis on visual space and object perception abilities. METHODS: Fifty-three @entity0 with mild @entity3 that were eventually diagnosed with probable @entity8 ( @entity3 ) and @entity6 ( @entity3 : n = 28) at a 3-year follow-up were retrospectively studied. At the first visit, the @entity0 underwent cognitive assessment including the Qualitative Scoring Mini Mental State Examination Pentagon Test and the Visual Object and Space Perception Battery. The @entity4 Inventory Questionnaire, Unified @entity5 Rating Scale (UPDRS) and questionnaires for @entity3 and @entity2 were also administered. RESULTS: The best clinical predictor of @entity8 was the presence of soft extrapyramidal signs (mean UPDRS score: 4.04    5.9) detected in 72% of @entity0 , followed by @entity9 (60%) and fluctuations (60%). Wrong performances in the pentagon's number of angles were obtained in 44% of @entity8 and 3.7% of @entity6 @entity0 and correlated with speed of visual attention. Executive functions, @entity7 were worse in @entity8 , while @entity3 was greater in @entity6 . @entity7 were present in both @entity3 and @entity6 . CONCLUSIONS: Poor performance in the pentagon's number of angles is specific of @entity8 and correlates with speed of visual attention. The dorsal visual stream seems specifically more impaired in @entity3 with respect to the ventral visual stream, the latter being involved in both @entity8 and @entity6 . These cognitive features, associated with @entity1 , should alert clinicians to a diagnostic hypothesis of @entity8 .

title: Clinical and Cognitive Phenotype of Mild XXXX Evolving to Dementia with Lewy Bodies.

answer: @entity3


abstract: OBJECTIVE: To compare the effects of two different recruitment maneuvers repeated multiple times on gas exchange @entity0 , hemodynamic, and lung mechanics. DESIGN: Randomized prospective comparison. SETTINGS: Animal research laboratory. SUBJECT: Nineteen fasted Hampshire @entity1 . INTERVENTIONS: In 15 27-kg @entity1 with saline lavage @entity0 , we compared the effects of two recruitment maneuvers: 40 cm @entity2 continuous positive airway pressure for 60 secs and 40 cm @entity2 positive end-expiratory pressure with 20 cm @entity2 pressure control, rate 10 breaths/min, inspiratory to expiratory ratio 1:1 for 2 mins. Each recruitment maneuver was repeated four times, every 30 mins after a 30-sec ventilator disconnection. An additional group received no recruitment maneuvers. Animals were assigned randomly to the three groups and ventilated with 20 cm @entity2 positive end-expiratory pressure, pressure control 15 cm @entity2 , rate 20 breaths/min, inspiratory to expiratory ratio 1:1, and Fio2 1.0 between recruitment maneuver periods. MEASUREMENTS AND MAIN RESULTS: Significant and marked increases in Pao2 were observed in the pressure control recruitment maneuver group but only after the second recruitment maneuver. In both the control group and continuous positive airway pressure groups, Pao2 did not significantly increase after any recruitment maneuver compared with baseline injury. There was a significant decrease in cardiac output immediately after some continuous positive airway pressure recruitment maneuvers and a significant increase in mean pulmonary artery pressure in both continuous positive airway pressure and pressure control groups immediately after recruitment maneuvers, but these changes resolved within 10 mins. There were no marked histologic differences between groups and no volutrauma. CONCLUSION: In this model, maximal lung recruitment was obtained with 40 cm @entity2 positive end-expiratory pressure and 20 cm @entity2 pressure control applied repetitively every 30 mins for 2 mins without physiologic or histologic harm. Multiple recruitment maneuvers in some animals were required for maximum effect.

title: Repetitive high-pressure recruitment maneuvers required to maximally recruit lung in a XXXX model of acute respiratory distress syndrome.

answer: @entity1


abstract: AIMS: Emerging research may soon lead to improved quit rates via genetically-tailored smoking cessation treatment. The purpose of this study was to explore individuals' beliefs and attitudes about genetic testing in this context, and how these may differ across racial groups. DESIGN: Two site qualitative study. METHODS: Eleven focus groups were conducted in 2007 with 51 Black and 55 White adult @entity0 in Montgomery, AL and Baltimore, @entity1 . MEASUREMENTS: Questions were asked about smoking as an addiction, the role of genetics in @entity2 addiction susceptibility, and undergoing genetic testing to receive tailored smoking cessation treatment. Data were analyzed using content analysis. FINDINGS: Most @entity0 believed that smoking was an addiction yet were unwilling to endorse the notion that genetics played a role in @entity2 addiction susceptibility. However, 91% of White @entity0 and 62% of Black @entity0 indicated that they would likely take a genetic test that would match them to their optimal smoking cessation treatment. The primary potential benefit was a vague sense that additional knowledge about oneself would be of value. Primary barriers included disinterest and skepticism about the test, unwillingness to believe that genetics played a role in @entity2 addiction or treatment response, and concerns about psychological consequences. CONCLUSIONS: The majority of @entity0 , particularly Black @entity0 , did not believe that genetics played a significant role in @entity2 addiction susceptibility but were willing to undergo genetic testing. @entity0 identified some benefit to tailoring smoking treatment by genotype. However, @entity0 also expressed skepticism about the test and concerns about its consequences; these issues would need to be addressed in the clinical encounter.

title: Black and White adults' perspectives on the genetics of XXXX addiction susceptibility.

answer: @entity2


abstract: Various materials such as autogenous bone, cartilage and alloplastic implants have been used to reconstruct @entity6 . A new material is needed because of disadvantages of nonresorbable alloplastic materials and difficulties in harvesting autogenous tissues. In this study safety and value of the use of resorbable mesh plate in the treatment of @entity6 are discussed. Between 2002 and 2004 a total of 17 maxillofacial @entity1 @entity0 complicated with @entity6 were treated with resorbable mesh plate through subciliary or transconjunctival incisions. Pure blow-out @entity2 were determined in 6 @entity0 and 11 @entity0 had accompanying maxillofacial @entity2 . Resorbable plate was easily shaped to fit to the orbital floor by cutting with scissors. @entity0 were evaluated clinically and with computed tomography scans preoperatively and at 3-, 6- and 12-month intervals postoperatively. Twelve @entity0 had @entity7 . Two @entity0 had @entity4 that was corrected postoperatively. In all 17 cases there was no evidence of @entity3 , @entity4 and gaze restriction postoperatively. Scleral show appeared in three @entity0 by the second postoperative week but resolved totally within 3 to 6 weeks except one @entity0 . In this @entity0 anterior displacement of mesh was evident which caused ectropion and @entity7 and required re-operation. No any other mesh related problems were seen at 15 months mean follow-up time. The advantage of the resorbable mesh system in @entity6 is the maintenance of orbital contents against @entity5 forces during the initial phase of healing and then complete resorption through natural processes after its support is no longer needed. Our experience represents that resorbable mesh is a safe and effective material for reconstruction of the selected, @entity6 .

title: Reconstruction of traumatic XXXX with resorbable mesh plate.

answer: @entity6


abstract: UNASSIGNED: Voltage-gated @entity7 channels (VGSCs) mediate action potential firing and regulate adhesion and migration in excitable cells. VGSCs are also expressed in @entity2 cells. In metastatic @entity0 ( @entity0 ) cells, the @entity5 a subunit potentiates migration and invasion. In addition, the VGSC-inhibiting antiepileptic drug @entity6 inhibits @entity2 growth and @entity1 . However, the functional activity of @entity5 and its specific contribution to @entity2 progression in vivo has not been delineated. Here, we found that @entity5 is up-regulated at the protein level in @entity0 compared with matched normal breast tissue. Na+ current, reversibly blocked by @entity3 , was retained in @entity2 cells in @entity2 tissue slices, thus directly confirming functional VGSC activity in vivo. Stable down-regulation of @entity5 expression significantly reduced @entity2 growth, local invasion into surrounding tissue, and @entity1 to liver, lungs and spleen in an orthotopic @entity0 model. @entity5 down-regulation had no effect on cell proliferation or angiogenesis within the in @entity2 , but increased apoptosis. In vitro, @entity5 down-regulation altered cell morphology and reduced @entity4 expression, suggesting that VGSC activity may regulate cellular invasion via the @entity4 -src-cortactin signaling axis. We conclude that @entity5 is functionally active in @entity2 cells in @entity0 , enhancing growth and metastatic dissemination. These findings support the notion that compounds targeting @entity5 may be useful for reducing @entity1 .

title: @entity5 regulates XXXX growth and metastatic dissemination in vivo.

answer: @entity0


abstract: An enormous number of synthetic chemicals are incorporated in topical drugs, cosmetics and toiletries. These have the potential to cause irritant reactions when chronically applied to @entity0 skin. In predictive tests for assessing the irritancy potential of these chemicals, haired species, especially @entity3 , @entity5 and @entity1 , have figured prominently. Customarily these tests, including the renowned Draize @entity3 test, have entailed a single acute exposure or at most daily exposures over a few weeks. Estimation of @entity2 and tissue injury in these models have relied on visual assessment. We submit that this approach is no longer acceptable. Visual assessments are unreliable. Reactions which are scored equivalently by the naked eye may differ strikingly when examined histologically. Moreover, tissue injury may be present in clinically normal skin. Short-term results. even when abetted by routine histological evaluations, cannot predict the degree of injury from long-term exposures. Cosmetics and toiletries, for example, are used daily for decades, often over most of the lifespan of @entity0 who are well groomed. We present the hairless @entity1 as a convenient, reliable model for assessing the chronic @entity4 of diverse chemicals. Histological examination enables a detailed description of the different tissue components which participate in the complex cascade of changes that comprise the inflammatory response.

title: A hairless XXXX model for assessing the chronic @entity4 of topically applied chemicals.

answer: @entity1


abstract: UNASSIGNED: @entity0 with @entity5 ( @entity5 ) are often tested for @entity1 , which are hereditary and acquired conditions that predispose to @entity4 . If a @entity2 is identified, then testing is often performed on members of the @entity0 's family. Testing for these conditions can be complex, as the presence of acute @entity4 and antithrombotic therapies can make the results of many tests unreliable. Many risk factors for @entity4 exist that are not routinely assessed by laboratory testing, and it is likely that many @entity2 remain to be discovered. Also, various risk factors for @entity4 interact with one another. Therefore, the results of a laboratory @entity1 evaluation provide a limited ability to assess a @entity0 or family members' risk for future @entity4 , and such testing usually does not provide information that improves a management decision. @entity1 testing is expensive and carries potential risks. This article reviews common @entity1 , their epidemiology and classification, and timing and technical aspects of accurate testing and provides rational suggestions for the use of @entity1 testing in five clinical situations: (1) following provoked @entity5 (or other @entity6 ), (2) following unprovoked @entity6 , (3) in relatives of @entity0 with @entity4 , (4) in female relatives of @entity0 with @entity4 considering @entity3 use, and (5) in female relatives of @entity0 with @entity4 who are considering pregnancy. Published guidelines and guidance statements from professional societies and other groups are also reviewed. Clinicians should carefully consider the relevant risks and benefits before testing @entity0 for @entity1 . When performed, testing should be timed correctly and care should be taken to properly interpret results. New models that incorporate multiple genetic and clinical markers may improve the utility of testing, but these await further research.

title: Thrombophilic Evaluation in XXXX with @entity5 .

answer: @entity0


abstract: BACKGROUND/AIMS: Parthenogenetic embryos are useful in many applications, such as being an alternative source of embryonic stem cells that would avoid ethical problems. Aberrance in epigenetic reprogramming is considered the major reason for the developmental failure of parthenogenetic embryos. Many histone deacetylase inhibitors have been shown to improve the reprogramming of stem cells and embryos. Here, the relationship between histone modification and parthenogenetic embryonic development was explored. METHODS: @entity0 ( @entity1 ) treatment was applied during the culture of parthenogenetic embryos. The abundance of histone modifiers was examined by immunofluorescence and quantified by Image-pro software. RESULTS: The acH3K9 level in in vitro fertilized embryos was significantly higher than parthenogenetic embryos. @entity1 treatment improved both the blastocyst formation rate and the acH3K9 level in parthenogenetic embryos. The signal intensities of acH4K5 and H3K4me2 were also enhanced in @entity1 treated embryos. The H3K27me2 level was decreased in the @entity1 treated embryos at the 2-cell stage. However, the enhancement in the acH3K9, acH4K5 and H3K4me2 level, or the decrease in the H3K27me2 level disappeared shortly after @entity1 withdrawal. CONCLUSION: Optimizing histone modifications for a short time following activation was sufficient to enhance the in vitro development of parthenogenetic embryos.

title: XXXX Improves Porcine Parthenogenetic Embryo Development Through Transient Remodeling of Histone Modifiers.

answer: @entity0


abstract: The authors report a case of 25-year-old @entity0 with a rare acute presentation of @entity4 ( @entity4 ) as an @entity3 . Right salpingoo-ooferectomy was performed. The pathological diagnosis was @entity4 One month after the surgery there was a three-cm @entity2 in the contralateral ovary and the @entity1 size increased to six cm in diameter in the following month. Serum inhibin-B levels progressively increased. Cystectomy was performed to contralateral ovary as frozen-section examination indicated @entity1 . Final histopathological examination revealed @entity1 . Regarding her request, the @entity0 was reoperated again and unilateral oophorectomy and hysterectomy were performed. Clinicians must be aware of the possibility of an underlying @entity1 associated with adnexal torsion even in young @entity0 . Frozen section will be helpful in order to avoid incomplete surgeries. Cyst rapidly growing in the ovary in young @entity0 should raise the suspicion of a de novo @entity1 .

title: XXXX presenting with @entity3 and de novo @entity3 in the contralateral ovary.

answer: @entity4


abstract: INTRODUCTION: Adrenohepatic fusion means union between the adrenal gland and the liver, intermingling its parenchymas. It is not possible to identify this condition by image tests. Its presence implies radical and multidisciplinar approach. PRESENTATION OF CASES: We report two female cases of 45 and 50 years old with clinical virilization and palpable mass on the abdominal right upper quadrant corresponding to @entity7 with hepatic fusion. The contrast-enhanced tomography showed an indistinguishable mass involving the liver and the right adrenal gland. In the first case, the @entity0 had a two-time operation, the former removing only the @entity8 , and the second performing a radical surgery after an early relapse. In the second case, a radical right en bloc adrenohepatectomy was performed. Both cases were pathologically reported as @entity3 . Only in the second case the surgery was radical effective as first intention to treat, with 3 years of disease-free survival. DISCUSSION: ACC is a rare entity with poor prognosis. The major indicators of @entity2 are @entity2 diameter over 6cm, local invasion or @entity1 , secretion of @entity6 , virilization and @entity4 and hypokalaemia. The parenchymal fusion of the adrenal cortical layer can be misdiagnosed as @entity5 with adhesion with the Glisson capsule. AHF in such cases may be misinterpreted during surgery, what may impair its resectability, and therefore the survival. The surgical treatment must be performed en bloc, often using liver vascular control. Postoperative treatment must be offered immediately after surgery. CONCLUSION: We report two consecutive rare cases of adrenohepatic fusion in giant right @entity7 , not detectable by imaging, what has important implications for the surgical decision-making. As radical surgery is the best choice to offer a curative treatment, it has to be performed by a multidisciplinary well-assembled team, counting with endocrine and liver surgeons, and transplant surgeons in case of vena cava involvement, in order to maximize the disease-free survival.

title: Adrenohepatic fusion: Adhesion or invasion in primary XXXX ? Implications for surgical resection. Two case report and review of the literature.

answer: @entity8


abstract: In a controlled and randomised double-blind study, 26 healthy adult volunteers consumed, for 21 d, 400 ml of a rose-hip drink containing oats (0.7 g/100ml) fermented with @entity1 DSM 9843 (RHL; containing 5 x 10(7) cfu ml(-1)), and 22 volunteers in a second group the same amount of a pure rose-hip drink (RH). Significant increases in the total faecal concentration of @entity4 (P < 0.05 after 1 week and P < 0.01 after 3 weeks of intake), @entity2 (P < 0.01 after 3 weeks of intake) and @entity3 (P < 0.01 after 3 weeks of intake and P < 0.05 eight days after intake ceased) were recorded in the RHL group, indicating increased fermentation in the colon. In both groups a significant increase was obtained in the concentration of faecal @entity0 (P < 0.001 after 1 and 3 weeks of intake). No changes were seen in the concentration of faecal butyrate. The numbers of faecal bifidobacteria and lactobacilli increased significantly in both groups after 3 weeks of intake. @entity5 -reducing clostridia rapidly decreased in the group receiving the product with Lb. plantarum DSM 9843 after 1 week of intake, and then also in the pure rose-hip group after 3 weeks of intake. No changes were seen in the numbers of total anaerobes, gram-negative anaerobes or total aerobes during administration. Lb. plantarum DSM 9843 was recovered in faeces from all volunteers in the RHL group. Median amounts were 7.0 (5.0-8.8) log10 cfu g(-1) after one week of intake, and 6.7 (5.0-8.9) log10 cfu g(-1) after 3 weeks, respectively. The strain was still recovered from faeces of five volunteers 8 d after administration ceased (> 4.8 log10 cfu g(-1)). During the period of intake the volunteers in the RHL group experienced a significant increase in stool volume, a significant decrease in flatulence and slightly softer stools. Volunteers in the RH group experienced a slight but significant decrease in stool volume.

title: Survival of XXXX DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats.

answer: @entity1


abstract: BACKGROUND: @entity11 ( @entity11 ) is a common @entity1 in @entity0 with @entity5 . Despite the development of new therapeutic agents, a majority of @entity0 will require parathyroidectomy. The aim of this study was to evaluate total parathyroidectomy with auto-transplantation of trace amounts of parathyroid tissue as a surgical option in @entity13 @entity11 treatment. METHODS: Clinical data of 50 @entity11 @entity0 who underwent total parathyroidectomy with auto-transplantation between January 2011 and December 2013 were reviewed retrospectively. Symptoms such as @entity3 and @entity4 , concentrations of intact parathyroid hormone (iPTH), levels of ionized @entity8 and serum @entity10 , and activity of alkaline phosphatase were recorded before and after parathyroidectomy. RESULTS: After operation, signs of @entity2 , @entity3 and @entity7 was disappeared, iPTH level and serum @entity12 concentration were declined markedly. No @entity6 were observed. Follow-up observation was around 28 months. One female @entity0 (2%) died 3 months after surgery due to @entity9 , and another @entity0 (2%) had persistent disease. All other @entity0 recovered during the follow-up period. CONCLUSIONS: Total parathyroidectomy with auto-transplantation of trace amounts of parathyroid tissue was considered to be a feasible, safe and effective surgical option for the treatment of @entity11 .

title: Application of total parathyroidectomy with auto-transplantation for XXXX secondary hyperparathyroidism treatment.

answer: @entity13