abstract: INTRODUCTION: Our study was designed to explore the hemodynamic effects of intravenous administration of @entity4 -inhibitor @entity6 in comparison with standard inotropic-vasodilator therapy. @entity0 with poor left ventricular function following coronary artery bypass (CABG) surgery were examined. MATERIALS AND METHODS: Thirty @entity0 with poor left ventricular function (EF<30%) following CABG surgery with use of cardiopulmonaly bypass were examined. Fourty @entity0 were control group. All @entity0 had complete invasive hemodynamic monitoring. The @entity4 -inhibitor @entity6 0.5 mg/h was administered intravenously via infusion pump. The following parameters were analyzed: arterial blood pressure, systemic vascular resistance, pulmonary vascular resistance, heart rate, cardiac output, cardiac index, left @entity2 work index and the level of mixed venous @entity1 saturation. RESULTS: The results of our study were as follows: Cardiac output, cardiac index and left @entity2 work index were significantly increased in comparison to the control group. Systemic arterial systolic pressure and pulmonary vascular resistance were decreased and there was no significant difference in systemic vascular resistance, mixed venous @entity1 saturation, heart rate and diastolic blood pressure in comparison to the control group. DISCUSSION: Our results pointed at very satisfactory hemodynamic effects of @entity6 on " @entity5 ", after CABG surgery. The @entity4 inhibitors greatly reduce mortality in @entity0 in all stages of @entity3 , from asymptomatic dysfunction of the left ventricle to severe symptomatic stages. CONCLUSION: In prevention of @entity3 in @entity0 with impaired left ventricle function (LVEF<30%), who had undergone CABG surgery with use of cardiopulmonaly bypass, we achieved the best effects on the hemodynamics with parenteral administration of @entity6 .

title: [Hemodynamic effects of intravenous administration of @entity4 inhibitor in prevention of XXXX following coronary artery bypass surgery].

answer: @entity3


abstract: The @entity4 ( @entity4 ) plays an important role in the development and @entity1 and its overexpression is associated with decreased survival. With progression, @entity1 cells switch from @entity5 ( @entity5 ) to @entity2 ( @entity7 ) synthesis, which contributes to autocrine growth and unrestrained proliferation. To define the molecular mechanisms involved in the regulation of @entity4 expression by @entity5 and @entity7 we studied three @entity0 @entity1 cell lines, @entity3 -responsive (LNCaP) and -unresponsive (DU145 and @entity6 ). Here we show that @entity7 stabilized @entity4 mRNA two- to threefold in all three cell lines, whilst @entity5 stabilized @entity4 mRNA approximately twofold in LNCaP and DU145 cells, but not in @entity6 cells. Both ligands increased @entity4 transcription in LNCaP and DU145 cells, with less effect in @entity6 cells. In all three cell lines @entity5 reduced total @entity4 protein levels more than @entity7 , but this was associated with a greater increase in de novo protein synthesis with @entity5 compared to @entity7 . Only @entity5 , however, shortened @entity4 protein stability (half-life decreased from 5 h to 120 min), resulting in rapid disappearance of newly synthesized @entity4 protein. Both ligands increased total LNCaP and DU145 cell numbers. These studies demonstrate that the @entity5 - and @entity7 -induced upregulation of @entity4 mRNA and protein in @entity0 @entity1 cell lines is complex and occurs at multiple, transcriptional and post-transcriptional levels. Taken together, these data provide novel insight into the molecular mechanisms by which @entity7 would preferentially maintain an autocrine loop in @entity0 @entity1 cells. Furthermore, this work suggests that in @entity0 @entity1 cells ligand-specific differential intracellular trafficking of the @entity4 plays a major role in regulating its expression.

title: Complex post-transcriptional regulation of XXXX -receptor expression by @entity5 and @entity7 in @entity0 @entity1 cells.

answer: @entity5


abstract: BACKGROUND: Integrins participate in cell-cell and cell-matrix interactions. In this study we determined whether alphaII(b)beta3 integrin is involved in @entity1 of @entity0 @entity4 cells. METHODS: @entity4 @entity6 and DU-145 cell lines express alphaII(b)beta3. Northern blotting, 5'-RACE, and immunofluorescent localization confirmed expression of alphaIIb integrin in @entity4 cells. We used orthotopic/ectopic site of implantation and lung colonization assays in @entity5 @entity3 to determine whether alphaII(b)beta3 participates in metastatasis of @entity2 cells. RESULTS: Immunofluorescent localization of alphaIIb integrin in fibronectin-adherent DU-145 and @entity6 cells is remarkably different. In DU-145 cells the integrin localizes to focal contact sites, whereas it is predominantly intracellular in @entity6 cells. Both @entity2 cell lines are tumorigenic when implanted subcutaneously or intraprostatically in @entity5 @entity3 , but only DU-145 cells injected intraprostatically metastasize. Flow cytometry with a mAb directed to alphaII(b)beta3 revealed higher expression of alphaII(b)beta3 in DU-145 @entity2 cell suspensions isolated from the prostate when compared to DU-145 @entity2 cells from the subcutis. Function-blocking mAbs to alphaII(b)beta3 inhibit lung colonization of tail vein-injected DU-145 cells. CONCLUSIONS: Altogether, the data suggest that alphaII(b)beta3 integrin participates in the metastatic progression of @entity4 .

title: Role of alphaII(b)beta3 integrin in prostate cancer XXXX .

answer: @entity1


abstract: @entity4 and collagen concentrations were determined in intimal-medial samples of ascending aortas from healthy controls of different ages and from 20 @entity0 with @entity2 ( @entity2 ). Five @entity0 had the @entity3 . In controls the highest @entity4 concentrations (estimated from @entity5 concentrations or insoluble residues after hot-alkali extraction) were found in @entity0 . During aging until 60 years, @entity4 concentration decreased when determined by the hot-alkali extraction method while @entity5 concentration changed less. Aorta samples from the @entity3 @entity0 showed a great variation of @entity4 concentration from total lack to normal values. Samples from the other @entity2 @entity0 could be divided into two groups. One contained clearly less @entity4 and more collagen than the controls whereas in the other group this difference was less marked. Histological examination of the aortic wall of the first group also showed marked @entity1 accompanied by severe @entity4 fragmentation and acellularity. From the 15 non-Marfan @entity0 14 were @entity0 . By means of clinical examination these @entity0 could also be divided into "familial" and "nonfamilial" groups, because increased diameter of the aortic root was found in relatives of almost half of the @entity0 . However, there were no differences in @entity4 and collagen concentrations between the familial and nonfamilial cases. As well, no correlation was found between biochemical findings and diameters of the aortic roots. These results point to altered @entity4 and/or collagen metabolism in the aortic wall of @entity2 @entity0 .

title: @entity4 and collagen in the aortic wall: changes in the @entity3 and XXXX .

answer: @entity2


abstract: AIMS: Disease management programs (DMP) for @entity1 ( @entity1 ) or @entity3 ( @entity3 ) address the treatment of @entity6 . The current registry aimed to compare drug utilization, lipid lowering effects and further outcomes of outpatients at high cardiovascular risk in DMP for @entity1 or @entity3 compared to @entity0 in routine care (no-DMP). METHODS: This was a prospective non-interventional registry with a 1 year follow-up which enrolled consecutive @entity0 with known @entity1 and/or any @entity4 on @entity5 40   mg monotherapy, to document lipid target achievement in clinical practice in Germany according to existing guidelines. Drug use (maintenance, add-on, switch, discontinuation) and other components of care were upon the discretion of the treating physician. RESULTS: Of a total of 12,154 @entity0 (mean age 65.8 years, 61.2% males), 3273 were in DMP @entity3 , 3265 in DMP @entity1 and 1760 in DMP @entity3   +   @entity1 . In DMP @entity0 compared to no-DMP @entity0 , comorbidities/risk factors were more frequent. More @entity0 in the DMP groups attained the target level of low density lipoprotein (LDL-C) <70   mg/dl (1.8   mmol/l) at baseline (8.5% DMP vs. 5.7% no-DMP), at 6 month (10.3% vs. 7.4%) and 12 month follow-up (10.1% vs. 7.1%). @entity2 absorption inhibitors were added in 16% of the @entity0 at the end of the baseline or at the follow-up visits, while @entity7 treatment (including mean dose) remained largely unchanged. Target achievement rates were highest for all time points in the DMP @entity3   +   @entity1 group. With respect to limitations, this study was restricted to @entity6 as qualifying diagnosis and @entity5 as qualifying treatment, which is a potential cause of selection bias. Information on non-pharmacological measures was not collected, and the 12-month follow-up period was relatively short. CONCLUSION: @entity0 in DMP compared to those not in DMP achieved better LDL-C lowering and higher control rates, but overall lipid target achievement rates need to be improved. Longer-term observations are needed to corroborate these findings.

title: Better lipid target achievement for secondary prevention through disease management programs for @entity1 and XXXX in clinical practice in Germany.

answer: @entity3


abstract: AIM: To compare the effect of scaling and root planning (SRP) alone, and laser curettage as an adjunct to SRP, on the clinical parameters of @entity0 with @entity6 and @entity1 . MATERIALS AND METHODS: Ten @entity0 were divided into two equal groups in a split-mouth design - Group I: SRP alone, Group II: SRP + laser curettage. The following clinical parameters were recorded: (i) Gingival index (ii) plaque index (iii) sulcular bleeding index (iv) @entity3 ( @entity3 ) and (v) @entity4 ( @entity4 ). SRP was done in one quadrant using Gracey curettes and in another quadrant SRP plus laser curettage was done. Three weeks after the therapy, the clinical parameters were recorded and the results were analyzed and the percentage of improvement were evaluated. RESULTS: The results of this study indicated that both SRP and SRP + laser curettage were efficient for reducing @entity2 and @entity3 . Group II showed more @entity5 in @entity4 than Group I. Mean @entity3 was 20.22% in Group I and 26.76% in Group II. Mean @entity4 gain is 32.5% in Group II and 22.34% in Group I. CONCLUSION: In both the groups, @entity2 was reduced. When laser curettage was used as adjunct to SRP more @entity3 and @entity4 was seen.

title: LASER curettage as adjunct to SRP, compared to SRP alone, in XXXX with @entity6 and @entity1 : A comparative clinical study.

answer: @entity0


abstract: OBJECTIVE: This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and @entity6 in @entity0 with @entity1 . @entity0 : There were 30 clinically definite @entity1 @entity0 , with different disease courses. EXCLUSION CRITERIA: psychoactive/ @entity4 treatments, @entity5 , acute relapse phase. MAIN OUTCOME MEASURES: Neuropsychological test results. Total ( @entity7 ) and frontal (FLL) lesion loads assessed from PD-weighted, T1-weighted (22 @entity0 ), and MTI (22 @entity0 ) MRI scans. Average lesion MT ratios (MTR) and analysis of the MTR histograms from brain tissue axial slabs on MTI scans. RESULTS: @entity0 with @entity3 (n=15) or @entity6 (n-17) had a higher @entity7 on PD scans (p=0.04 and p=0.01, respectively). @entity0 with @entity3 had higher FLL on PD scans (p=0.01) and @entity7 on MTI (p=0.03) scans. No significant relationships between the extent of T1-weighted lesion loads and the presence of any @entity2 . Mean MTR of both @entity3 and whole brain tissue was lower in @entity0 @entity3 (p=0.04). MRI lesion loads correlated significantly with some neuropsychological test scores. CONCLUSIONS: Lesion loads on PD-weighted MRI and MTI-derived measures are associated with @entity2 in @entity1 @entity0 . Overall macroscopic and microscopic @entity3 is more important than the corresponding regional @entity3 in determining deficits of selective cognitive domains.

title: Relation between MR abnormalities and patterns of XXXX in @entity1 .

answer: @entity2


abstract: BACKGROUND: @entity6 is the most common @entity1 in Malaysia. Confirmation of the b-globin gene mutations involved in @entity3 is usually carried out by molecular analysis of DNA extracted from leukocytes in whole blood. Molecular analysis is generally carried out when affected @entity0 are around 1 - 2 years as clinical symptoms are expressed during this period. Blood taking at this age can be distressing for the @entity0 . High yield and pure DNA extracted from non-invasive sampling methods can serve as alternative samples in molecular studies for @entity1 especially in pediatric cases. METHODS: In this study, mouthwash, saliva, and buccal cytobrush samples were collected from @entity3 major @entity0 who had previously been characterized using DNA extracted from peripheral blood. DNA was extracted from mouthwash, saliva, and buccal cytobrush samples using the conventional inexpensive @entity5 - @entity4 method and was measured by spectrophotometry for yield and purity. Molecular characterization of b-globin gene mutations was carried out using the @entity2 ( @entity2 ). RESULTS: DNA extracted from mouthwash, saliva, and buccal cytobrush samples produced high concentration and pure DNA. The purified DNA was successfully amplified using @entity2 . Results of the b-globin gene mutations using DNA from the three non-invasive samples were in 100% concordance with results from DNA extracted from peripheral blood. CONCLUSIONS: The conventional in-house developed methods for non-invasive sample collection and DNA extraction from these samples are effective and negate the use of more expensive commercial kits. In conclusion, DNA extracted from mouthwash, saliva, and buccal cytobrush samples provided sufficiently high amounts of pure DNA suitable for molecular analysis of @entity3 .

title: Non-Invasive DNA Sampling for Molecular Analysis of @entity6 : Amiable Alternative Sampling Methods with Accurate Results for Pediatric XXXX .

answer: @entity0


abstract: UNASSIGNED: Preclinical studies suggest that @entity3 ( @entity3 ) may improve post- @entity2 recovery, and clinical trials investigating safety are ongoing. However, knowledge about @entity0 ' attitudes to @entity3 in @entity2 is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors influencing this among @entity2 @entity0 potentially suitable for @entity3 . Consecutive first-ever acute @entity1 @entity2 @entity0 aged 20-75 years with @entity2 scale scores 1-18 were included. Exclusion criteria were severe comorbidities or @entity2 . Clinical follow-up after 3-5 years assessed severity of @entity2 , cognitive function, functional status, @entity0 -reported outcome, comorbidity, and after receiving standardized information, the @entity0 also completed an 8-item questionnaire on knowledge and attitudes about @entity3 . The relations between clinical variables and positive attitude to @entity3 were assessed with logistic regression analyses. Of 108 @entity0 included at baseline, 84 participated at follow-up and completed the questionnaire. In total, 12% had prior knowledge of @entity3 . When informed, 63% were positive towards it and 36% reported willingness to participate in @entity3 trials. Only 5-8% expressed ethical considerations regarding different stem cell sources. Positive attitudes to @entity3 were associated with male gender (OR: 3.74; 95% CI: 1.45-9.61; p<0.01) and better @entity0 -reported outcome (OR: 1.02; 95% CI: 1.00-1.04; p<0.05). In conclusion, @entity2 @entity0 had limited prior knowledge of @entity3 , yet attitudes were positive among the majority after receiving standardized and neutral information. Gender and degree of @entity2 recovery may influence attitudes to @entity3 , indicating a need for targeted information to improve knowledge about @entity3 .

title: Attitudes to Stem Cell Therapy among Ischemic Stroke Survivors in the Lund XXXX Recovery Study.

answer: @entity2


abstract: BACKGROUND: @entity7 mutations in @entity1 can confer resistance to @entity2 inhibitors, although preexisting @entity7 (P124) mutations do not preclude clinical responses. We sought to determine whether recurrent, preexisting @entity7 (P124) mutations affected clinical outcome in @entity2 inhibitor-treated @entity0 with @entity1 . METHODS: Data from four published datasets were analyzed to determine whether preexisting @entity7 (P124) mutations affect radiologic response or progression-free survival (PFS) in @entity0 with @entity2 (V600)-mutant metastatic @entity1 treated with @entity4 or @entity5 . The effects of @entity7 (P124) mutations on MAPK pathway activity and response to @entity2 inhibition were also investigated in a series of cell models. RESULTS: In a pooled analysis of 123 @entity0 , the presence of a pretreatment @entity7 (P124) mutation (N = 12, 10%) was associated with a poorer RECIST response (33% vs. 72% in @entity7 ( @entity8 /S) vs. @entity7 ) wild-type, P = 0.018), and a shorter PFS (median 3.1 vs. 4.8 months, P = 0.004). Furthermore, @entity7 ( @entity8 /S) mutations were shown to have independent kinase activity and introduction of these mutations into a @entity2 -mutant @entity1 cell line diminished inhibition of @entity3 phosphorylation by @entity5 and enhanced clonogenic survival in the presence of @entity5 compared with cells ectopically expressing wild-type @entity7 . Consistent with these data, two @entity2 -mutant cell lines with endogenous @entity7 (P124) mutations showed intermediate sensitivity to @entity5 , but were highly sensitive to downstream inhibition of @entity6 or @entity3 . CONCLUSION: Taken together, our data indicate that preexisting @entity7 (P124) mutations are associated with a reduced response to @entity2 inhibitor therapy and identify a subset of @entity0 with @entity2 -mutant @entity1 likely to benefit from combination therapies involving @entity6 or @entity3 inhibitors. Clin Cancer Res; 1-8.   2014 AACR.

title: Preexisting MEK1P124 Mutations Diminish Response to XXXX Inhibitors in @entity1 @entity0 .

answer: @entity2


abstract: OBJECTIVE: Tuberculosis of the adrenal glands is a common cause of @entity4 in developing countries. We conducted a study to determine if treatment of such @entity0 with modern anti- @entity1 chemotherapy would lead to an improvement in plasma @entity2 and @entity3 levels. DESIGN: Prospective study. @entity0 : 5 @entity0 with @entity4 secondary to @entity1 . MEASUREMENTS: Basal and ACTH stimulated plasma @entity2 and @entity3 levels were measured prior to instituting anti- @entity1 chemotherapy, as well as one month after its conclusion. Four @entity0 were again studied over the next 2-5 years. RESULTS: Peak plasma @entity2 levels prior to treatment were markedly reduced (range, < 14-110 mumol/l). There was no improvement one month (< 14-143 mumol/l) or 2-5 years (< 14-69 mumol/l) after completing anti- @entity1 chemotherapy. Peak plasma @entity3 at diagnosis was < 56-210 pmol/l; it was undetectable in 4 @entity0 . No improvement was observed one month (< 56-210 pmol/l), or 2-5 years (< 56-389 pmol/l) after stopping anti- @entity1 chemotherapy. Plasma @entity3 levels at both these time points were far lower than those in control subjects (median 736 pmol/l, 560-1512 pmol/l; p < 0.01). One @entity0 had an increase in peak @entity3 from < 56 pmol/l to 389 pmol/l, though peak @entity2 actually declined in this subject (from 110 mumol/l to 69 mumol/l). CONCLUSIONS: Treatment of @entity1 @entity4 with anti- @entity1 chemotherapy does not lead to normalization of ACTH stimulated plasma @entity2 or @entity3 levels during the 2-5 year period of study. However, prolonged follow up with regular adrenal function tests is warranted in all such @entity0 .

title: Tuberculous XXXX : lack of normalization of adrenocortical function after anti- @entity1 chemotherapy.

answer: @entity4


abstract: BACKGROUND: @entity1 ( @entity1 ) can be managed with rhythm- or rate-control strategies. There are few data from routine clinical practice on the frequency with which each strategy is used and their correlates in terms of @entity0 ' clinical characteristics, @entity1 control, and symptom burden. METHODS: RealiseAF was an international, cross-sectional, observational survey of 11,198 @entity0 with @entity1 . The aim of this analysis was to describe @entity0 profiles and symptoms according to the @entity1 management strategy used. A multivariate logistic regression identified factors associated with @entity1 management strategy at the end of the visit. RESULTS: Among 10,497 eligible @entity0 , 53.7% used a rate-control strategy, compared with 34.5% who used a rhythm-control strategy. In 11.8% of @entity0 , no clear strategy was stated. The proportion of @entity0 with @entity1 -related symptoms (EHRA Class > = II) was 78.1% (n = 4396/5630) for those using a rate-control strategy vs. 67.8% for those using a rhythm-control strategy (p<0.001). Multivariate logistic regression analysis revealed that age <75 years or the paroxysmal or persistent form of @entity1 favored the choice of a rhythm-control strategy. A change in strategy was infrequent, even in @entity0 with European Heart Rhythm Association (EHRA) Class > = II. CONCLUSIONS: In the RealiseAF routine clinical practice survey, rate control was more commonly used than rhythm control, and a change in strategy was uncommon, even in symptomatic @entity0 . In almost 12% of @entity0 , no clear strategy was stated. Physician awareness regarding optimal management strategies for @entity1 may be improved.

title: XXXX Management Strategies in Routine Clinical Practice: Insights from the International RealiseAF Survey.

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) is a @entity3 with a wide variety of clinical manifestations. There are few studies describing the clinical and epidemiological profile of @entity2 in peripheral or rural areas. Over the last decades, the frequency in which this disease is diagnosed has increased due to greater awareness and availability of noninvasive diagnostic techniques. MATERIALS AND METHODS: A hospital-based retrospective case review of adult (>= 15 years) @entity0 with @entity2 between 2001 and 2012 is described. 31 @entity0 with confirmed imagiological diagnosis of @entity2 were included. STATISTICAL ANALYSIS USED: Statistical analysis was performed using R version 2.15.2. Incidence rate was computed as number of new cases by time. Confidence interval (CI) was set at 95% and P < 0.05 was considered significant. RESULTS: The average annual incidence was 0.84 (CI: 0.58-1.18) to 0.73 (CI: 0.5-1.02) per 100 000 cases for adult population. There were 23 (74%) @entity0 and 8 (26%) @entity0 . Predominant initial manifestations were @entity1 , followed by @entity5 and @entity4 . Median diagnostic delay from onset of illness was 8 days. All @entity0 were treated with unfractionated heparin or low-molecular heparin followed by @entity6 . Complete recovery occurred in the majority of cases 22 (78.6%) but two @entity0 died during hospitalization. CONCLUSIONS: Albeit with some particularities, the epidemiology and clinical manifestations we found are comparable to what has been reported in western studies.

title: Clinicoepidemiological profile of XXXX in Algarve, Portugal: A retrospective observational study.

answer: @entity2


abstract: PURPOSE: To investigate the surgical outcome of rectangular 4-snip punctoplasty, a modification of rectangular 3-snip procedures, using objective measurements. DESIGN: Noncomparative case series. METHODS: The medical charts of @entity0 who underwent rectangular 4-snip punctoplasty for severe @entity1 with at least 6 months follow-up were reviewed. Before surgery and at 1 and 6 months after surgery, subjective evaluation of tearing was assessed using Munk scores. The size of the punctum was graded based on slit-lamp examination, and measurement of tear meniscus height was done using Fourier-domain optical coherence tomography. RESULTS: A total of 45 eyes (26 @entity0 ) were studied. The subjective @entity2 score was significantly reduced after surgery and maintained until 6 months after the surgery (  2 for trend test, P<.001). The grade of the punctum size was also significantly enlarged after surgery and the enlarged punctum was maintained until 6 months after the surgery (  2 for trend test, P<.001). The mean preoperative tear height (452.4  249.3  m) was significantly reduced both at 1 month after surgery (341.6  207.9  m; P=.003, paired t test) and at 6 months after surgery (362.1  212.6  m; P=.004, paired t test). The functional success rate was 93.3% and anatomic success rate was 88.9% at 6 months after surgery. CONCLUSIONS: Rectangular 4-snip punctoplasty was an anatomically and functionally effective procedure for severe @entity1 @entity0 , maintaining large puncta for fairly long periods.

title: Outcomes of 4-snip punctoplasty for severe XXXX : measurement of tear meniscus height by optical coherence tomography.

answer: @entity1


abstract: OBJECTIVE: We aimed to confirm the efficacy of @entity5 in Japanese postmenopausal @entity0 ( @entity0 ) @entity1 , and investigate factors contributing @entity4 ( @entity4 ) prolongation. RESEARCH DESIGN AND METHODS: This retrospective study included 194 @entity0 @entity1 who received @entity5 (500  mg) from January 2012 to December 2014. MAIN OUTCOME MEASURES: @entity4 (efficacy measure), overall survival (OS), factors prolonging @entity4 and adverse events were evaluated. RESULTS: The median age was 65 (42 - 90) years. Overall, @entity4 was 5.48 months. In @entity1 without prior chemotherapy (n  =  59), OS was significantly longer (p  =  0.0131) than in @entity1 with prior chemotherapy (n  =  135). There was no strong correlation between @entity4 with @entity5 and other endocrine therapies, total duration of endocrine therapy and maximum duration of endocrine therapy. @entity4 was significantly longer in @entity1 with less than two prior chemotherapy regimens (p  =  0.0093), de novo @entity2 (p  =  0.0124) and without liver @entity2 (p  =  0.0024). We observed one case each of @entity6 and @entity3 . CONCLUSIONS: @entity5 is effective for @entity0 @entity1 and may show greater efficacy in @entity1 with few prior chemotherapy regimens, de novo @entity2 and absence of liver @entity2 . Prior endocrine therapy duration might not be a predictive factor for @entity5 @entity4 in heavily treated @entity0 @entity1 .

title: Efficacy of @entity5 500 mg in Japanese postmenopausal @entity0 XXXX and factors associated with prolonged time-to-treatment failure.

answer: @entity1


abstract: BACKGROUND/OBJECTIVE: @entity9 is a potent @entity5 and @entity8 inhibitor. @entity1 - @entity6 (GC) is a standard chemotherapy regimen for advanced/metastatic @entity3 . This phase I study examined the safety of @entity9 in combination with GC in @entity0 with @entity3 . The primary aim was to determine the maximum tolerated dose (MTD) of @entity9 in combination with GC. METHODS: A 3 + 3 dose escalation protocol was used with @entity9 at 750, 1,000 and then 1,250 mg. It was dosed daily with @entity1 (1,000 mg/m2 on days 1, 8 and 15) and @entity6 (70 mg/m2 on day 2) every 28 days. In all, 18 @entity0 with a median age of 63 years (range 50-77) were included; 3/6, 3/5 and 6/7 @entity0 received @entity9 at 750, 1,000 and 1,250 mg, combined with GC, in cohorts 1, 2 and 3, respectively. RESULTS: No dose-limiting @entity2 (DLTs) were observed in cohort 1 or 2 (3 @entity0 each); in cohort 3 (2 * 3 @entity0 ), 1 of the 6 @entity0 presented DLTs (grade 4, treatment-related @entity7 and @entity4 ). Twelve @entity0 received 6 cycles. CONCLUSIONS: @entity9 at 750-1,250 mg combined with GC appears safe and tolerable. The MTD of @entity9 combined with GC in @entity3 was 1,250 mg.

title: Results from a Phase I Study of @entity9 with XXXX and @entity6 in Advanced or Metastatic @entity3 : EORTC Trial 30061.

answer: @entity1


abstract: Dispersed ethnic populations believe their health to be worse than the ethnic majority group in Sweden. Most studies in rehabilitation exclude dispersed ethnic populations who can not read or speak the national language although this group seems to be in need of rehabilitation to a larger extent than privileged majority groups. The aim of the study was to examine the experience of living with @entity3 and experience of health care among dispersed ethnic populations of Muslim @entity0 . The method used was inspired by Grounded Theory in this study. Interviews were made with five first-generation Muslim immigrant @entity0 who had come to Sweden via Iraq as refugees. Two interviews were performed with interpreters. A preliminary core category 'The magnitude of reciprocity' based on three categories emerged from the analysis: (1) Impact of @entity1 , (2) Managing @entity1 and (3) Facing health care. @entity2 limited the informants physically and emotionally, as well as impacting on their everyday life. Informants managed their @entity1 primarily through medicine and physical activity, which gave at least temporary relief. Health care providers were perceived as doing their best but experiences of bad meetings were also witnessed. The factors important in achieving a good meeting in this study appeared to be; time, dialogue, honesty and understanding. Communication skills, feelings of being taken seriously and a sense of security were additional factors. Not being properly examined, or offered optimal treatment, not being believed or understood, were all seen as signs of dismissal within health care. The limitations of this study are primarily concerned with language difficulties resulting in various shortcomings. Reciprocal recognition and support connected to the specific life experiences of @entity0 that come with forced resettlement from the Muslim world to the European diaspora is a vital part of a holistic approach to @entity1 management.

title: The magnitude of reciprocity in @entity2 management: experiences of dispersed ethnic populations of Muslim XXXX .

answer: @entity0


abstract: INTRODUCTION: The optimal choice of first-line chemotherapy for @entity0 with relapse of @entity1 ( @entity1 ) after perioperative @entity2 -based chemotherapy (PCBC) is unclear. We investigated the outcomes with @entity2 rechallenge versus a non- @entity2 regimen in @entity0 with recurrent metastatic @entity1 after PCBC in a multicenter retrospective study. @entity0 AND METHODS: Individual @entity0 -level data were collected for @entity0 who had received various first-line chemotherapy regimens for advanced @entity1 after previous PCBC. Cox proportional hazards models were used to investigate the prognostic ability of the type of perioperative and first-line chemotherapy to independently affect @entity3 ( @entity3 ) and progression-free survival (PFS) after accounting for known prognostic factors. RESULTS: Data were available for 145 @entity0 (12 centers). The mean age was 62 years; the Eastern Cooperative Oncology Group (ECOG) performance status (PS) was > 0 for 42.0% of the @entity0 . Of the 145 @entity0 , 63% had received @entity2 -based first-line chemotherapy. The median time from previous chemotherapy (TFPC) was 6.2 months (range, 1-154 months). The median @entity3 was 22 months (95% confidence interval [CI], 18-27 months), and the median PFS was 6 months (95% CI, 5-7 months). A better ECOG PS and a longer TFPC (> 12 months vs.   <= 12 months; hazard ratio [HR], 0.32; 95% CI, 0.20-0.52; P  < .001) was prognostic for @entity3 and PFS. @entity2 -based chemotherapy was associated with poor @entity3 (HR, 1.86; 95% CI, 1.13-3.06; P  = .015), which appeared to be pronounced in those @entity0 with a TFPC of   <= 12 months. Retreatment with @entity2 in the first-line setting was associated with worse @entity3 (HR, 3.38; P  < .001). CONCLUSION: The results of the present retrospective analysis suggest that for @entity0 who have undergone previous PCBC for @entity1 , rechallenging with @entity2 might confer a poorer @entity3 , especially for those with progression within  <  1  year.

title: @entity2 - Versus Non- @entity2 -based First-Line Chemotherapy for Advanced @entity1 Previously Treated With Perioperative XXXX .

answer: @entity2


abstract: OBJECTIVE: To investigate the effects of liposomal formulation on @entity2 nano-liposomes (SMV-liposome) promoting the osteogenic differentiation of @entity0 bone marrow stromal cells (BMSC) analyzed by the expressions of @entity4 ( @entity4 ) and @entity3 ( @entity3 ). METHODS: Primary BMDC were cultured in vitro using adherence and culture of whole bone marrow method. SMV dosage was set as control group and had two different dosages in this group on the basis of the concentration of SMV. 1  mol/L and 2  mol/L SMV concentration were represented by SMV low dosage group (S1) and SMV high dosage group (S2), respectively. Similarly, SMV-liposome dosage was set as experimental group including two different dosages, 1  mol/L SMV capsuled concentration as SMV-liposome low dosage group ( @entity5 ) and 2  mol/L SMV capsuled concentration as SMV-liposome high dosage group ( @entity6 ). Besides, groups with no drug intervention in the experiments were set as blank. BMSC were treated with different concentrations of SMV and SMV-liposome for 48 h, the activity of @entity3 was measured using p-nitropheny-phosate method, and @entity3 expression in the BMSC cells was stained by BCIP/NBT @entity3 color development kit (BCIP/NBT Kit). Furthermore, @entity4 expression in the BMSC was determined by Western Blot. RESULTS: @entity1 assay showed, after incubated with different concentrations of SMV and SMV-liposome, the cell viabilities of BMSC were all above 85% and had no significant difference in the groups. Compared with the same dosage of SMV in these groups, control group and experimental group had significantly elevated the specific activity of @entity3 , the staining of BCIP/NBTKit as well as the protein expression of @entity4 . Besides, the data showed dose-dependent elevation in the control group and experimental group, namely the high dose group had better results than the low dose group. CONCLUSION: Nano-liposomal formulation significantly enhanced SMV effects on the osteogenetic differentiation of BMSC.

title: [Effects of XXXX nano-liposomes on osteogenic differentiation of bone marrow stromal cells].

answer: @entity2


abstract: UNASSIGNED: @entity0 are more likely than @entity0 to suffer from @entity5 ( @entity5 ) and @entity3 . In addition to their sex bias, these disorders share stress as an etiological factor and hyperarousal as a symptom. Thus, sex differences in brain arousal systems and their regulation by stress could help explain increased vulnerability to these disorders in @entity0 . Here we review preclinical studies that have identified sex differences in the locus coeruleus (LC)- @entity6 (NE) arousal system. First, we detail how structural sex differences in the LC can bias females towards increased arousal in response to emotional events. Second, we highlight studies demonstrating that @entity2 can increase NE in LC target regions by enhancing the capacity for NE synthesis, while reducing NE degradation, potentially increasing arousal in females. Third, we review data revealing how sex differences in the stress receptor, @entity8 ( @entity8 ), can @entity4 to @entity7 in females compared to males. This effect could translate into hyperarousal in @entity0 under conditions of @entity7 hypersecretion that occur in @entity5 and @entity3 . The implications of these sex differences for the treatment of stress-related @entity1 are discussed. Moreover, the value of using information regarding biological sex differences to aid in the development of novel pharmacotherapies to better treat @entity0 and @entity0 with @entity5 and @entity3 is also highlighted. This article is part of a Special Issue entitled SI: Noradrenergic System.

title: Sex differences in the locus coeruleus- XXXX system and its regulation by stress.

answer: @entity6


abstract: AIM: To identify the most effective treatment of @entity3 ( @entity3 ) after gastrectomy for @entity6 . METHODS: A systematic review of the literature was performed. PubMed, EMBASE, Cochrane Library, CILEA Archive, BMJ Clinical Evidence and UpToDate databases were analyzed. Three hundred eighty-eight manuscripts were retrieved and analyzed and thirteen studies published between 1988 and 2014 were finally selected according to the inclusion criteria, for a total of 145 cases of @entity3 , which represented our group of study. Only @entity0 with @entity3 after gastrectomy for @entity1 were selected. Data about @entity0 ' characteristics, type of treatment, short and long-term outcomes were extracted and analyzed. RESULTS: In the 13 studies different types of treatment were proposed: conservative approach, surgical approach, percutaneous approach and endoscopic approach (3 cases). The overall mortality rate was 11.7% for the entire cohort. The more frequent complications were @entity4 , @entity5 , @entity7 , @entity2 and @entity8 . Conservative approach was performed in 6 studies for a total of 79 @entity0 , in @entity0 with stable general condition, often associated with percutaneous approach. A complete resolution of the leakage was achieved in 92.3% of these @entity0 , with a healing time ranging from 17 to 71 d. Surgical approach included duodenostomy, duodeno-jejunostomy, pancreatoduodenectomy and the use of rectus muscle flap. In-hospital stay of @entity0 who underwent relaparotomy ranged from 1 to 1035 d. The percutaneous approach included drainage of abscesses or duodenostomy (32 cases) and percutaneous biliary diversion (13 cases). The median healing time in this group was 43 d. CONCLUSION: Conservative approach is the treatment of choice, eventually associated with percutaneus drainage. Surgical approach should be reserved for severe cases or when conservative approaches fail.

title: Management of XXXX after gastrectomy for @entity6 : Systematic review.

answer: @entity3


abstract: STUDY DESIGN:: Retrospective review. OBJECTIVE:: To describe a safe surgical procedure, en bloc resection of the posterior wall of the thoracic canal, for the decompression of severe @entity2 caused by tuberous ossification of the ligamentum flavum (OLF). SUMMARY OF BACKGROUND DATA:: OLF has been widely recognized as a cause of @entity2 in East Asia. Surgical decompression of @entity2 caused by OLF is technically demanding. Although several surgical decompression procedures have been described, acute @entity1 is common. METHODS:: Eighteen @entity0 with severe @entity2 caused by tuberous OLF underwent posterior decompression via segmental en bloc resection of the posterior wall of the thoracic canal. The ossified ligamentum flavum, laminae, and partial facet joints of each segment were resected en bloc. Ossified dura mater was removed if present. Posterior fixation with pedicle screws was followed by lateral bone graft fusion. RESULTS:: The mean preoperative modified Japanese Orthopaedic Association (mJOA) score (total score, 11) was 4.1 (range, 2-5). Postoperatively, no @entity1 occurred, and all @entity0 improved clinically. With an average follow-up of 31.2 months (range, 24-42 mo), the average mJOA score was 7.8 (range, 6-10), representing a 2-5-point improvement. The average improvement rate was 55.2% (range, 33.3%-83.3%). Most @entity0 were functionally independent at the last follow-up. Forty ossified segments were resected. The average time required for the resection of one segment was 77 minutes. Intraoperatively, dural ossification was noted in 11 @entity0 . Complete resection was performed in all @entity0 . @entity3 occurred in 5 @entity0 . CONCLUSIONS:: Segmental en bloc resection of the posterior wall of the thoracic canal is a safe and effective alternative for OLF-related severe @entity2 .

title: Surgical Technique for Decompression of Severe XXXX Due to Tuberous Ossification of Ligamentum Flavum.

answer: @entity2


abstract: AIM: Adherence and colonization of candida on denture soft liners is the most important contributing factor in development of @entity3 . This invitro study is undertaken to investigate whether the incorporation of tea tree oil into denture soft liners would inhibit the growth of @entity2 . MATERIALS AND METHODS: Each 10 specimen disks incorporated with tea tree oil into soft liners (St) and without tea tree oil (S) were prepared. Both the tea tree oil daily. These disks were inoculated with @entity2 suspension for assessment of fungal growth and were rinsed with sterile water to remove loosely attached surface organisms. The attached @entity0 were measured by inoculating them on saboraud's agar. Treated and control disks were stored in distilled water for 1, 30, 60 days and washed daily with wet @entity1 . Data between treated and control disks were compared by applying t-test. RESULTS: The mean colony forming units (CFU) per mm(2) for specimens without tea tree oil after water storage and wash with wet @entity1 for 1, 30 and 60 days was 7.1 * 10(6), 6.5 * 10(6), 6.8 * 10(6), respectively and for specimens with tea tree oil CFU decreased significantly to 2.1 * 10(6), 2.8 * 10(6), 3.1 * 10(6) after 1, 30 and 60 days. Treated disks were effective in controlling the growth of @entity2 for two months following water storage. CONCLUSION: Addition of tea tree oil to denture soft liner significantly reduced growth of @entity2 suggesting a new form of intra oral effective antifungal management for @entity3 .

title: Invitro Antifungal Evaluation of Denture Soft Liner Incorporated with Tea Tree Oil: A New Therapeutic Approach Towards XXXX .

answer: @entity3


abstract: @entity5 metabolism studies using a combination of isotopic and chromatographic procedures were carried out in two strains of @entity0 fed 5% @entity4 (36% of calories) in the diet. Feeding @entity4 to the Fisher @entity0 over 17 days produced no significant changes in body weight. @entity2 levels in various tissues were elevated in the @entity4 -fed group: plasma @entity2 , +61%; liver @entity2 , +47%; and bile @entity2 , +57%. The @entity3 -fed Fisher @entity0 showed several changes in @entity5 metabolism over controls: fecal acidic steroid output, +13%; fecal neutral @entity5 output, +51%; endogenous neutral @entity5 output, +107%; @entity2 turnover, +54%; and @entity2 balance, +18%. @entity4 feeding to the @entity0 showed similar differences between @entity4 -fed vs. control @entity0 . @entity2 levels were significantly elevated in plasma (+35%) and in the liver (+81%). @entity5 metabolism data showed the following differences ( @entity3 vs. control): fecal acidic @entity1 output, +9%; fecal neutral @entity5 output, +17%; endogenous neutral @entity5 output, +72%; @entity2 turnover, +33%; and @entity2 balance +13%. The Fisher @entity0 maintained almost constant weight throughout the experimental period and is a preferable strain for @entity5 balance studies using liquid diets. A major finding of these experiments was the increased concentration of @entity2 in liver, plasma, and bile in both strains of @entity0 . The @entity5 balance measurements indicated that this tissue accumulation of @entity2 was due to enhanced @entity2 synthesis as well as inhibition of @entity6 syntheses.

title: @entity5 metabolism in the @entity0 : effect of XXXX on @entity5 metabolism in two strains of @entity0 .

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: We conducted a phase II study using @entity8 and @entity7 on @entity0 with recurrent @entity2 to investigate @entity1 response. METHODS: From January 1995 to March 1997, 21 @entity0 with recurrent @entity2 were treated with a @entity8 (300 mg/m(2), day 1)/ @entity7 (100 mg/m(2), days 1-3) regimen every 3-4 weeks. The following radiologic parameters were evaluated: @entity1 size, central lucency, degree of contrast enhancement, and mass effect. No @entity0 had received chemotherapy previously. Dose escalation corresponded to hematologic tolerance and to general and neurologic performance status. Most @entity0 were treated postoperatively with involved field radiotherapy followed by a boost to the @entity1 area, as defined on the presurgery computed tomography scan or on magnetic resonance imaging. Mean interval to introduction of chemotherapy was 8.8 months (range, 7-36 months). @entity0 received a mean of four cycles [range, 2-8 cycles]. RESULTS: Only 2 @entity0 showed moderate radiological response, while 12 @entity0 died of progressive disease. Mean time to progression following discontinuation of chemotherapy was 5.8 months (range, 1-11 months). The other @entity0 survived with persistent disease and are being treated palliatively. @entity4 was manageable (1, @entity6 ; 1, @entity5 (45,000/mm(3)); 2, temporarily elevated transaminase level; 2, @entity3 -induced @entity9 ). CONCLUSIONS: This phase II regimen proved to be ineffective in recurrent @entity2 . Further studies incorporating innovative drug regimens and schedules are warranted. J. Surg. Oncol., 1999;71:167-170.

title: @entity8 and @entity7 for recurrent XXXX following surgical and radiotherapy failure: A clinical study conducted at the Northern Israel Oncology Center.

answer: @entity2


abstract: BACKGROUND: We demonstrated that ventromedial hypothalamus (VMH) lesions facilitate DNA synthesis, which reflects cell proliferation in abdominal organs, including the liver, pancreas, stomach, small intestine and large intestine, all of which are amply innervated by the vagal nerve. OBJECTIVE: To investigate which area DNA synthesis facilitates and what factors contribute to cell proliferation in the small intestine in VMH-lesioned @entity0 . DESIGN: At 7 days after @entity1 or sham operations, a segment of @entity0 jejunum was taken for histological examination. A part of the jejunum was also removed from VMH-lesioned and sham-operated @entity0 after 3 days and examined for @entity3 ( @entity3 ) incorporation. At 6, 12 and 24 h after @entity1 , the proximal intestine was removed from individual @entity0 , from the pylorus to the mid-jejunum. Total RNA was extracted from these tissues of each @entity0 , and the levels of epidermal growth factor (EGF) and transforming growth factor (TGF)-alpha mRNA were determined using reverse-transcription polymerase chain reaction. @entity6 mRNA levels were determined using Northern blotting. RESULTS: : Jejunal villi in VMH-lesioned @entity0 were markedly enlarged compared to those of sham-operated @entity0 and jejunal crypts in VMH-lesioned @entity0 more markedly incorporated @entity3 . Northern blot analysis revealed an increase in @entity7 mRNA after 6, 12 and 24 h in the jejunum of VMH-lesioned @entity0 . @entity5 mRNA was decreased 6 and 12 h after VMH lesioning; however, it was significantly increased 24 h after @entity1 in comparison to sham-operated @entity0 . The levels of EGF and @entity8 mRNA were unchanged in VMH lesioned @entity0 . CONCLUSION: @entity1 induced @entity2 and increased the gene expression of @entity7 in the small intestine. @entity4 , probably E(2), induced by @entity7 may be one candidate factor responsible for the cell proliferation of the small intestinal epithelium in these @entity0 .

title: XXXX induce jejunal epithelial cell hyperplasia through an increase in gene expression of cyclooxygenase.

answer: @entity1


abstract: OBJECTIVE: To assess @entity2 ( @entity2 ) relatives' and @entity0 ' opinions on: (1) discussing @entity3 ( @entity3 ) with relatives soon after @entity2 death after @entity4 and (2) acceptability of organ preservation procedures both before and after discussion with relatives. METHODS: Questionnaire study; convenience sample. RESULTS: 200 questionnaires were completed. 37.5% of @entity0 were male subjects; mean age was 40.4 (SD 16.9; range 15-85) years. There was no difference in the number willing to discuss @entity3 after @entity1 in intensive care unit compared with circulatory death in the @entity2 (72% vs 72%; p=0.146). The majority were willing to discuss @entity3 soon after @entity2 death after @entity4 (106; 54%). 41 (21%) were not willing and 43 (22%) had no strong views (n=198). Organ preservation procedures (groin tube insertion, continuation of mechanical cardiopulmonary resuscitation and continuation of ventilator) were acceptable to between 48% and 57% of respondents if performed before discussion with family increasing to an acceptability of between 64% and 69% after discussion with family. One in four respondents felt these procedures were not acceptable regardless of the timing of discussion with family and some felt these procedures were more acceptable if the @entity0 was a registered organ donor. 122 (61%) @entity0 wished to donate their organs after death but only 59 (30%) were registered donors. CONCLUSIONS: (1) The majority of @entity0 and their relatives are not averse to @entity3 being discussed shortly after @entity2 death. (2) Organ preservation procedures are acceptable to many. Prior discussion and prior organ donor registration may improve acceptability.

title: Are the public ready for @entity3 after out of hospital XXXX ?

answer: @entity4


abstract: BACKGROUND: Hand hygiene is considered as an important means of @entity2 control. We explored whether guided hand hygiene together with transmission-limiting behaviour reduces @entity2 episodes and lost days of work in a common work environment in an open cluster-randomized 3-arm intervention trial. METHODS: A total of 21 clusters (683 @entity0 ) were randomized to implement hand hygiene with soap and water (257 @entity0 ), with @entity1 -based hand rub (202 @entity0 ), or to serve as a control (224 @entity0 ). @entity0 in both intervention arms also received standardized instructions on how to limit the transmission of @entity2 . The intervention period (16 months) included the emergence of the 2009 @entity3 pandemic and the subsequent national hand hygiene campaign influencing also the control arm. RESULTS: In the total follow-up period there was a 6.7% reduction of @entity2 episodes in the soap-and water arm (p = 0.04). Before the onset of the anti-pandemic campaign, a statistically significant (p = 0.002) difference in the mean occurrence of @entity2 episodes was observed between the control (6.0 per year) and the soap-and-water arm (5.0 per year) but not between the control and the @entity1 -rub arm (5.6 per year). Neither intervention had a decreasing effect on absence from work. CONCLUSIONS: We conclude that intensified hand hygiene using water and soap together with behavioural recommendations can reduce the occurrence of self-reported acute illnesses in common work environment. Surprisingly, the occurrence of reported sick leaves also increased in the soap-and water-arm. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00981877 SOURCE OF FUNDING: The Finnish Work Environment Fund and the National Institute for Health and Welfare.

title: Hand washing with soap and water together with behavioural recommendations prevents XXXX in common work environment: an open cluster-randomized trial.

answer: @entity2


abstract: The @entity2 superficial digital flexor tendon (SDFT) functions as an energy store during high-speed gaits reducing the energetic cost of locomotion. To enable the SDFT to function effectively, the appropriate mechanical properties are essential. We tested the hypothesis that the SDFT does not undergo gross @entity1 in response to high-intensity exercise whereas tendons not involved in energy storage undergo adaptive @entity1 . Two groups (n = 6) of Thoroughbred fillies were trained at high-intensity on a high-speed @entity2 treadmill for 5 months (short-term study) or 18 months (long-term study). Age-matched groups (n = 6) of @entity2 undertook low-intensity exercise only for the same time period. Throughout the short-term study the SDFT and @entity0 ( @entity0 ) were ultrasonograpically scanned at mid-metacarpal level and cross-sectional area (CSA) calculated. At the end of the short-term study ( @entity2 age = 2 years) and long-term study ( @entity2 age = 3 years) the left SDFT, @entity0 , suspensory ligament (SL) and common digital extensor tendon (CDET) were harvested and CSA calculated. Comparison of the @entity0 from 2- and 3-year-old @entity2 revealed an age-related increase in CSA which was confirmed by ultrasonographs. Post mortem analysis showed a significant @entity1 of the CDET with high-intensity training in the short-term study (younger @entity2 ). CSA did not differ significantly between training groups for any of the structures following long-term training. These results suggest a structure specific @entity1 response to the imposed training regime.

title: Treadmill exercise-induced tendon XXXX : assessment of tendons with different mechanical functions.

answer: @entity1


abstract: BACKGROUND: As the most frequent bone @entity1 , spinal metastases cause severe @entity5 and damage to vertebral bodies such as @entity6 . To avoid the @entity4 and complications of open surgery, a minimally invasive procedure, percutaneous vertebroplasty ( @entity7 ), has recently been developed to treat metastatic @entity2 . PURPOSE: To analyze the treatment outcomes of metastatic @entity2 by percutaneous vertebroplasty ( @entity7 ) alone or @entity7 combined with interstitial implantation of 125I seeds. MATERIAL AND METHODS: 80 @entity0 with metastatic @entity2 were randomized to receive @entity7 alone (40 cases) or @entity7 combined with 125I seed implantation (40 cases). Digital subtraction angiography (DSA)-guided vertebroplasty was performed under local anesthesia, and acrylic bone cement was injected into the vertebra through a bone trocar to the center of the lesion, with or without simultaneous interstitial implantation of 125I seeds. RESULTS: At 6-month follow-up, @entity7 combined with 125I seed implantation resulted in zero cases with complete relief (CR), 36 with partial relief (PR), four with no changes (NC), and zero with @entity3 ( @entity3 ), while @entity7 alone without seed implantation resulted in 0 CR, 31 PR, 7 NC, and 2 @entity3 . While the combined-treatment group and the single- @entity7 group showed overall clinical benefit rates without significant difference (100% and 95.0%, respectively), their visual analogue @entity5 scales (VAS; 2.26+/-1.05 and 5.41+/-0.94, respectively) and Karnofsky performance scores (KPS; 92.5+/-7.1 and 87.7+/-7.3, respectively) were significantly different after treatment (P = 0.028 and P = 0.009, respectively). @entity0 in both groups had 1-year follow-up, and the mean time @entity2 ( @entity2 ) was 9.0 and 8.9 months, respectively (not significant). CONCLUSION: @entity7 is a minimally invasive procedure with small wounds and minor complications. It is effective in the alleviation of @entity5 in metastatic @entity2 @entity0 , and its clinical outcomes can be enhanced by the combination of interstitial implantation of 125I seeds.

title: Treatment of metastatic XXXX by percutaneous vertebroplasty versus percutaneous vertebroplasty combined with interstitial implantation of 125I seeds.

answer: @entity2


abstract: UNASSIGNED: Given that little is known about the prevalence of, and factors associated with, liver @entity3 in the general population, we aimed to investigate this in a large, well-characterized cohort by means of transient elastography (TE). This study was part of the Rotterdam Study, a population-based study among individuals >= 45 years. All @entity0 underwent abdominal ultrasound and TE. @entity4 measurement (LSM) >= 8.0 kilopascals (kPa) was used as a cutoff suggesting clinically relevant @entity3 . Of 3,041 @entity0 (age, 66.0        7.6 years) with reliable LSM, 169 (5.6%) @entity0 had LSM >= 8.0 kPa. Age (odds ratio [OR]: 2.40; 95% confidence interval [CI]: 1.72-3.36; P   <   0.001), @entity6 aminotransferase (ALT; OR, 1.24; 95% CI: 1.12-1.38; P   <   0.001), smoking (OR, 1.77; 95% CI: 1.16-2.70; P   =   0.008), spleen size (OR, 1.23; 95% CI: 1.09-1.40; P   =   0.001), @entity8 , or @entity7 (OR, 5.38; 95% CI: 1.60-18.0; P   =   0.006), and combined presence of @entity1 ( @entity1 ) and @entity5 (OR, 5.20; 95% CI: 3.01-8.98; P   <   0.001 for combined presence) were associated with LSM >= 8.0 kPa in multivariable analyses. The adjusted predicted probability of LSM >= 8.0 kPa increased per age decade, with probabilities ranging from 1.4% (0.9-3.6) in @entity0 ages 50-60 years to 9.9% (6.8-14.5) in @entity0 >80 years. @entity0 with both @entity1 and @entity5 had the highest probabilities of LSM >= 8.0 kPa (overall probability: 17.2% [12.5-23.4]; this probability did not increase with age [P   =   0.8]). CONCLUSION: In this large population-based study of older adults, LSM >= 8.0 kPa, suggestive of clinically relevant @entity3 , was present in 5.6% and was strongly associated with @entity5 and @entity1 . In the context of an aging population and an increased prevalence of @entity1 and @entity2 , this study illustrates that liver @entity3 may become a more prominent public health issue in the near future. (Hepatology 2015).

title: Presence of @entity1 and XXXX is associated with @entity4 in a general population: The Rotterdam study.

answer: @entity5


abstract: In the clinical grounds, @entity0 with >= 90  % luminal narrowing during @entity5 ( @entity6 ) testing had variable response. We investigated @entity1 findings and chest symptoms in @entity0 with >= 90  % luminal narrowing when performing ACh tests, retrospectively. We performed 763 ACh tests over 13  years (2001-2013). We analyzed chest symptoms and positive @entity1 ECG changes during ACh tests. More than 90  % luminal narrowing was found in 441 @entity0 (57.8  %) including 355 @entity0 in the right coronary artery (RCA) and 363 @entity0 in the left coronary artery (LCA). Chest symptom was observed in 386 @entity0 (87.5  %) including 293 @entity0 in the RCA and 304 @entity0 in the LCA. ST elevation was found in 161 @entity0 including 110 in the RCA and 85 @entity0 in the LCA, @entity3 was recognized in 146 @entity0 including 119 @entity0 in the RCA and 117 @entity0 in the LCA. Three quarter of @entity0 with >= 90  % luminal narrowing had significant @entity1 ECG changes, whereas two-third of @entity0 with >= 90  % luminal narrowing complained usual chest @entity2 accompanied with significant @entity1 ECG changes. Unusual chest symptom was complained in 7.3  % @entity0 with >= 90  % luminal narrowing. Neither chest symptom nor ECG changes were found in 30 @entity0 (6.8  %) with >= 90  % luminal narrowing. A third of these @entity0 had @entity1 findings on non-invasive tests before catheterization and six @entity0 had @entity4 . We should realize some limitation to define positive coronary @entity7 based on the @entity1 ECG change and chest symptom during ACh tests.

title: @entity7 on @entity5 @entity7 provocation tests: comparison of clinical positive XXXX .

answer: @entity7


abstract: OBJECTIVES: A sonographic study was conducted to determine the prevalence of @entity3 across multiple arterial beds in an elderly Chinese population and to examine relationships between detected @entity3 and traditional risk factors. METHODS: A total of 197 @entity0 underwent sonography of the abdominal aorta and bilateral carotid, femoral, and lower limb arteries. Images were reviewed to determine the presence or absence of plaques in each artery. Plaque thickness was measured as the indicator of plaque burden. Plaque prevalence was estimated per site and correlated with age, sex, and the Framingham Risk Score (FRS). Plaque frequency and thickness were compared between different arterial beds. RESULTS: Of the 197 @entity0 (54% female; age range, 58-86 years), 90% had plaques present in at least 1 artery, and 55% had plaques present in at least 4 arteries. The most common sites for plaques were the carotid arteries (80%), followed by the lower limb arteries (59%), femoral arteries (57%), and abdominal aorta (37%). Plaque prevalence in each arterial bed except the abdominal aorta was significantly associated with male @entity0 (P   <   .05), increasing age (P   <   .003) and FRS (P   <   .04). Male @entity0 were more likely to have carotid (P   =   .04), femoral (P   =   .045), and lower limb (P   =   .006) plaques than female @entity0 , but there was no significant difference in aortic plaque prevalence between male and female @entity0 (P   =   .9). CONCLUSIONS: Plaque prevalence increased significantly in the carotid and peripheral arteries with increasing FRS. These findings should be considered for designing screening programs for @entity1 and @entity2 prevention.

title: A Noninvasive Sonographic Study of Multisite XXXX in an Elderly Chinese Population.

answer: @entity3


abstract: BACKGROUND: @entity4 accounts for about 4.7% to 7.2% of all kinds of @entity4 , which is invasive with a relatively high recurrence and mortality. The objective of this study was to investigate the clinical manifestations and therapeutic strategies of @entity4 . METHODS: A total of 74 @entity0 who underwent surgical treatment and pathologically confirmed for @entity4 in Neurosurgery Department of Beijing Tiantan Hospital from January 2003 to December 2008 were enrolled in this study. The characteristics of the @entity1 as well as therapeutic regimens and follow-up data were reviewed. After surgery, 56 @entity0 underwent radiotherapy. @entity0 were followed up for about 3.5 years (range, 0.5 - 6.0 years), and 58 @entity0 completed follow-up. RESULTS: Of the 58 @entity0 who completed follow-up, good recovery was found in 30, @entity2 in 15, and @entity3 in 13. Of the 58 @entity0 , 21 had recurrent @entity4 and 18 underwent a second surgery. CONCLUSIONS: @entity4 is difficult to manage, with a high recurrence rate and poor survival. The extent of @entity1 resection and histological grade are the key determinants of outcome. Radiation therapy can be used as an adjunctive treatment after total or partial resection.

title: Clinical characteristics and therapeutic strategies of XXXX .

answer: @entity4


abstract: Segmenting and quantifying @entity1 from MRI is an important task for diagnosis, planning intervention, and for tracking @entity0 changes over time. However, this task is complicated by the lack of prior knowledge concerning @entity0 location, spatial extent, shape, possible displacement of normal tissue, and intensity signature. To accommodate such complications, we introduce a framework for supervised segmentation based on multiple modality intensity, geometry, and asymmetry feature sets. These features drive a supervised whole-brain and @entity0 segmentation approach based on random forest-derived probabilities. The asymmetry-related features (based on optimal symmetric multimodal templates) demonstrate excellent discriminative properties within this framework. We also gain performance by generating probability maps from random forest models and using these maps for a refining Markov random field regularized probabilistic segmentation. This strategy allows us to interface the supervised learning capabilities of the random forest model with regularized probabilistic segmentation using the recently developed ANTsR package-a comprehensive statistical and visualization interface between the popular Advanced Normalization Tools (ANTs) and the R statistical project. The reported algorithmic framework was the top-performing entry in the MICCAI 2013 Multimodal @entity2 Segmentation challenge. The challenge data were widely varying consisting of both high-grade and low-grade @entity0 four-modality MRI from five different institutions. Average Dice overlap measures for the final algorithmic assessment were 0.87, 0.78, and 0.74 for "complete", "core", and "enhanced" @entity0 components, respectively.

title: Optimal Symmetric Multimodal Templates and Concatenated Random Forests for Supervised XXXX Segmentation (Simplified) with ANTsR.

answer: @entity2


abstract: Longitudinal assessment of risk factors for @entity4 is necessary to provide evidence that a putative risk factor or risk indicator is a true risk factor. The purpose of the present study was to explore longitudinally a variety of markers as possible periodontal risk factors in subjects with little or no @entity4 at baseline. 415 subjects with mild or @entity4 were examined: medical and dental history; socioeconomic profile, clinical measurements, microbial samples and radiographic assessment of bone height were performed at baseline, and at a follow-up examination 2 to 5 years later. Mean @entity6 ( @entity6 ) at baseline was 1.99+/-0.37 mm while mean overall change was 0.1 mm which amounts to an annual rate of 0.04 mm. Overall mean clinical attachment level (1.75+/-0.6 mm) at baseline resulted in mean attachment change of 0.28 mm (0.12 mm annually). @entity1 ( @entity1 ) at baseline (mean 2.05+/-0.85 mm) resulting in a mean net loss of 0.1 mm. Approximately 10% of all sites presented for the second visit with @entity7 exceeding the threshold (4.4% annually), while only 2.2% of all sites exhibited @entity3 (0.88% annually). Older individuals exhibited greater mean bone loss but the least amount of @entity7 . Current smokers exhibited greater disease progression compared to non-smokers. Tooth morbidity (0.17 teeth/ @entity0 /year) was associated with greater baseline CAL and @entity2 , and an assortment of systemic conditions. Subjects who harbored @entity5 (Bf) at baseline had greater loss in @entity1 ; likewise, these subjects experienced greater proportions of losing sites and twice as much tooth mortality compared to Bf-negative @entity0 . Baseline clinical parameters correlated strongly with the outcome, i.e., subjects with deeper mean pocket depth at baseline exhibited greater increase in pocket depth overtime; while subjects with greater @entity7 at baseline exhibited greater @entity7 between the 1st and 2nd visits.

title: Longitudinal study of predictive factors for XXXX and tooth loss.

answer: @entity4


abstract: UNASSIGNED: Inhibitory @entity6 ( @entity6 )-mediated neurotransmission plays an important role in the regulation of the prefrontal cortex (PFC), with increasing evidence suggesting that dysfunctional GABAergic processing of the PFC may underlie @entity1 reported across @entity5 . @entity4 ( @entity7 ) is a psychostimulant that induces @entity3 in a subset of users, with repeat administration producing a progressively increased vulnerability to @entity3 following subsequent drug administration (sensitization). The aim here was to investigate changes to GABAergic mRNA expression in the PFC of @entity0 sensitized to @entity7 using quantitative polymerase chain reaction (qPCR). Male @entity0 (n=12) underwent repeated @entity4 (intraperitoneal (i.p.) or saline injections for 7 days. Following 14 days of withdrawal, @entity0 were challenged with acute @entity4 (1mg/kg i.p.) and RNA was isolated from the PFC to compare the relative mRNA expression of a range of @entity6 enzymes, transporters and receptors subunits. @entity7 challenge resulted in a significant sensitized behavioral (locomotor) response in @entity7 pre-treated animals compared with saline pre-treated controls. The mRNAs of transporters ( @entity8 and @entity9 ), ionotropic GABAA receptor subunits (a3 and b1), together with the metabotropic GABAB1 receptor, were upregulated in the PFC of sensitized @entity0 compared with saline controls. These findings indicate that GABAergic mRNA expression is significantly altered at the pre and postsynaptic level following sensitization to @entity7 , with sensitization resulting in the transcriptional upregulation of several inhibitory genes. These changes likely have significant consequences on @entity6 -mediated neurotransmission in the PFC and may underlie certain symptoms conserved across @entity5 , such as @entity2 .

title: GABAergic mRNA expression is upregulated in the prefrontal cortex of @entity0 sensitized to XXXX .

answer: @entity4


abstract: Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (a- @entity10 ) into @entity1 induce @entity3 ( @entity3 )-like Lewy body (LB) pathology formed by aggregated a- @entity10 in anatomically interconnected regions and significant @entity4 . The aim of the current study was to evaluate whether exogenous @entity1 a- @entity10 pre-formed fibrils (PFF) injected into the striatum of @entity2 would result in accumulation of LB-like intracellular inclusions and @entity4 . @entity2 received unilateral intrastriatal injections of either non-fibrillized recombinant a- @entity10 or PFF @entity1 a- @entity10 in 1- or 2- sites and were euthanized at 30, 60 or 180 days post-injection (pi). Both non-fibrillized recombinant a- @entity10 and PFF a- @entity10 injections resulted in phosphorylated a- @entity10 intraneuronal accumulations (i.e., diffuse Lewy neurite (LN)- and LB-like inclusions) with significantly greater accumulations following PFF injection. LB-like inclusions were observed in several areas that innervate the striatum, most prominently the frontal and insular cortices, the amygdala, and the substantia nigra pars compacta (SNpc). a- @entity10 accumulations co-localized with ubiquitin, @entity9 , and were @entity8 -positive and proteinase-k resistant, suggesting that PFF-induced pathology exhibits properties similar to @entity0 LBs. Although a- @entity10 inclusions within the SNpc remained ipsilateral to striatal injection, we observed bilateral reductions in nigral @entity5 neurons at the 180-day time-point in both the 1- and 2-site PFF injection paradigms. PFF injected @entity2 exhibited bilateral reductions in striatal dopaminergic innervation at 60 and 180 days and bilateral decreases in @entity6 ; however, @entity5 reduction was observed only in the striatum ipsilateral to PFF injection. Although the level of @entity5 asymmetry in PFF injected @entity2 at 180 days was insufficient to elicit motor deficits in @entity7 -induced rotations or forelimb use in the cylinder task, significant disruption of ultrasonic vocalizations was observed. Taken together, our findings demonstrate that a- @entity10 PFF are sufficient to seed the pathological conversion and propagation of endogenous a- @entity10 to induce a progressive, neurodegenerative model of a-synucleinopathy in @entity2 .

title: Intrastriatal injection of pre-formed @entity1 a-synuclein fibrils into @entity2 triggers a-synuclein pathology and bilateral XXXX .

answer: @entity4


abstract: BACKGROUND AND OBJECTIVE: @entity3 (' @entity4 ') is a novel, inhaled long-acting muscarinic antagonist. Therapeutic effects of @entity4 on @entity1 ( @entity1 ) have been demonstrated in Caucasian populations in several clinical trials. This was a randomized, double-blind, multi-centre phase-3 clinical trial to evaluate the efficacy and safety of @entity4 in a Korean population. METHODS: A total of 263 Korean @entity0 with moderate-to-severe @entity1 were randomized to receive @entity4 (400    g, bd) (Genuai) or placebo via a dry-powder inhaler. The primary end point was change in trough forced expiratory volume in one second (FEV1 ) at 12 weeks. Other lung function measurements, @entity1 exacerbation, health status (St George's Respiratory Questionnaire (SGRQ), dyspnoea ( @entity2 ( @entity2 ) and safety were assessed throughout the study period. RESULTS: A significant improvement in trough FEV1 from baseline was shown with @entity4 compared with the placebo (0.126   L, P   <   0.0001). Significant improvements were also demonstrated in peak FEV1 (0.190   L, P   <   0.0001), SGRQ and @entity2 . Furthermore, @entity4 significantly reduced the prevalence of exacerbations ( @entity4 , 5.4%; placebo, 15.6%, P   <   0.05), and the duration of exacerbations was shorter compared with placebo (rate ratio: 0.27; P   <   0.05). @entity4 (400    g) was well tolerated and the prevalence of adverse events was comparable with the placebo. CONCLUSIONS: Inhaled @entity4 (400    g) was shown to be safe and efficacious in Korean @entity0 with moderate-to-severe @entity1 . CLINICAL TRIAL REGISTRATION: NCT01636401 at Clinicaltrials.gov.

title: Efficacy and safety of XXXX in @entity0 with @entity1 : A phase 3 randomized clinical trial in a Korean population.

answer: @entity3


abstract: The goal of the present work was to investigate possible risk factors for the poor response of some cases of chronic @entity4 to endoscopic sinus surgery in spite of the precision of the surgical technique. Eleven adult @entity0 who were scheduled for revision endoscopic sinus surgery underwent a complete @entity3 workup. At the time of surgery, a tiny biopsy was taken from the maxillary sinus mucosa close to the middle turbinate. The specimens were processed for histochemical and transmission electron microscopic examination. Six @entity0 (55 per cent) proved to be @entity2 . Their sinus mucosa showed @entity5 (6.1 cells/mm(2)), and mast cell degranulation. This proves that allergens can reach the sinus mucosa and have a direct impact on it. Another three @entity0 (27 per cent) were non- @entity2 but exhibited @entity1 (5.0 cells/mm(2)), and two of them showed mast cell degranulation. These @entity0 were diagnosed as having nonallergic rhinosinusitis with @entity5 (NARSE). The nasal mucosa of the remaining two @entity0 did not reveal any characteristic pathological findings, and no pathologic diagnosis could be established for them. None of the @entity0 showed electron microscopic evidence of purulent inflammatory changes, and the bacterial cultures recovered normal respiratory flora in nine @entity0 (82 per cent). The present research spotlights the importance of @entity3 and nonallergic @entity5 of the mucosa as possible risk factors that may degrade the results of endoscopic sinus procedures and discusses some pertinent pathological and clinical aspects.

title: Some risk factors for refractory chronic XXXX : an immunohistochemical and electron microscopic study.

answer: @entity4


abstract: UNASSIGNED: Pregnancy is a critical period for brain metabolic programming, being affected by individual environment, such as nutrition, stress, and physical exercise. In this context, we previously reported a cerebral antioxidant upregulation and mitochondrial biogenesis in the offspring delivered from exercised mothers, which could provide neuroprotection against neonatal insults. @entity3 - @entity1 (HI) @entity2 is one of the most studied models of neonatal @entity4 ; disrupting motor, cognitive, and learning abilities. Physiopathology includes oxidative stress, allied to mitochondria energy production failure, glutamatergic excitotoxicity, and cell death. In this study we evaluated the effect of maternal swimming during pregnancy on offspring* s brain oxidative status evaluated fourteen days after HI stablishment. Swimming exercise was performed by female adult @entity0 one week before and during pregnancy, in controlled environment. Their offspring was submitted to HI on postnatal day 7, and the brain samples for biochemical assays were obtained in the weaning. Contrary to our expectations, maternal exercise did not prevent the oxidative alterations observed in brain from HI- @entity0 . In a general way, we found a positive modulation in the activities of antioxidant enzymes, measured two weeks after HI, in hippocampus, striatum, and cerebellum of pups delivered from exercised mothers. Reactive species levels were modulated differently in each structure evaluated. Considering the scenery presented, we concluded that HI elicited a neurometabolic adaptation in both brain hemispheres, particularly in hippocampus, parietal cortex, and cerebellum; while striatum appears to be most damaged. The protocol of aerobic maternal exercise was not enough to fully prevent HI-induced @entity2 .

title: Effect of maternal exercise on biochemical parameters in @entity0 submitted to neonatal @entity3 - XXXX .

answer: @entity1


abstract: INTRODUCTION: The Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been theorized as neural systems that regulate approach/ @entity1 . Behavioral activation/inhibition balance may change in @entity2 based on underlying alterations in systems supporting motivation and approach/ @entity1 , which may in turn be reflected in neuropsychiatric symptoms. METHOD: A total of 187 @entity0 (31 @entity0 diagnosed with behavioral variant of FTD [bvFTD], 13 semantic variant of primary progressive aphasia [svPPA], 14 right temporal variant FTD [rtFTD], 54 @entity3 [ @entity3 ], and 75 older healthy controls [NCs]) were included in this study. Changes in behavioral inhibition/activation were measured using the BIS/BAS scale. We analyzed the correlation between regional atrophy pattern and BIS/BAS score, using voxel-based morphometry (VBM). RESULTS: ADs had significantly higher BIS scores than bvFTDs and NCs. bvFTDs activation-reward response (BAS-RR) was significantly lower than ADs and NCs, though their activation-drive (BAS-D) was significantly higher than in ADs. Both @entity3 and rtFTD @entity0 had abnormally low activation fun-seeking (BAS-FS) scores. BIS score correlated positively with right anterior cingulate and middle frontal gyrus volume, as well as volume in the right precentral gyrus and left insula/operculum. CONCLUSIONS: @entity3 , bvFTD, and rtFTD @entity0 show divergent patterns of change in approach/withdrawal reactivity. High BIS scores correlated with preservation of right-predominant structures involved in task control and self-protective avoidance of potentially negative reinforcers. Damage to these regions in bvFTD may create a punishment insensitivity that underlies @entity0 ' lack of self-consciousness in social contexts.

title: Neural basis of motivational approach and XXXX in @entity2 .

answer: @entity1


abstract: PURPOSE: To compare the efficacy and safety of latanoprost, bimatoprost, travoprost and @entity6 in @entity3 (IOP) in @entity0 with primary @entity2 . METHODS: This was a prospective study conducted at a tertiary-care centre. One hundred and forty @entity0 with newly diagnosed primary @entity2 were randomly assigned to treatment with latanoprost (0.005%), bimatoprost (0.03%), travoprost (0.004%) or @entity6 gel (0.5%); 35 @entity0 were assigned to each group. All @entity0 were followed for 2, 6, and 12 weeks. The main outcome measure studied was the change in IOP at week 12 from the baseline values. Safety measures included recording of adverse events. RESULTS: The mean IOP reduction from baseline at week 12 was significantly more with bimatoprost (8.8 mmHg, 35.9%) than with latanoprost (7.3 mmHg, 29.9%), travoprost (7.6 mmHg, 30.8%) or @entity6 (6.7 mmHg, 26.6%) (ANOVA and Student's t-tests, p < 0.001). Among the prostaglandins studied, bimatoprost produced a maximum reduction in IOP (-2.71; 95% confidence interval [CI], -2.25 to -3.18) followed by travoprost (-1.27; 95% CI, -0.81 to -1.27) and latanoprost (-1.25; 95% CI, -0.79 to -1.71); these values were significant when compared to @entity6 at week 12 (Bonferroni test, p < 0.001). Latanoprost and travoprost were comparable in their ability to reduce IOP at each @entity0 visit. Ocular adverse-events were found in almost equal proportion in @entity0 treated with bimatoprost (41.3%) and travoprost (41.9%), with a higher incidence of @entity5 (24.1%) seen in the bimatoprost group. @entity6 produced a significant drop in heart rate (p < 0.001) at week 12 when compared to the baseline measurements. CONCLUSIONS: Bimatoprost showed greater efficacy when compared to the other @entity4 , and @entity6 was the most efficacious at lowering the IOP. Conjunctional @entity1 was mainly seen with bimatoprost. However, the drug was tolerated well and found to be safe.

title: Comparing the efficacy of latanoprost (0.005%), bimatoprost (0.03%), travoprost (0.004%), and @entity6 (0.5%) in the treatment of primary XXXX .

answer: @entity2


abstract: OBJECTIVE: To define the incidence of recall and dreams during analgosedation in critically ill @entity0 . DESIGN: Prospective clinical study. SETTING: Anaesthesiological intensive care unit (ICU) in a university hospital. @entity0 AND @entity0 : Two hundred and eighty-nine critically ill @entity0 , who either arrived intubated and sedated at the ICU or required intubation, mechanical ventilation, and sedation during their ICU stay. INTERVENTIONS: none. MEASUREMENTS AND RESULTS: The @entity0 were interviewed 48-72 h after discharge from the ICU. By a structured interview they were asked whether they recalled any event before they had regained consciousness at the ICU. Moreover they were asked for dreams. Descriptive statistics: 64.7% of all @entity0 did not recall any event, before they regained consciousness. However, 17% ( n=49) of all @entity0 indicated that they remembered the tracheal tube or being on the ventilator, before they woke up. Some @entity0 (21.1%) reported dreams or dreamlike sensations. Some @entity0 (9.3%) recalled nightmares, while 6.6% reported @entity1 . CONCLUSIONS: @entity2 @entity0 reported a high incidence of recall for unpleasant events, which they thought to have taken place before they regained consciousness. The @entity0 , who stayed longer than 24 h at the ICU, indicated vivid memory for nightmares and @entity1 . Further studies are suggested to evaluate: 1) whether there is an impact of the present findings on outcome; and 2) whether clinical scores for sedation or neurophysiological monitoring help to define the exact time, when recall happens, in order to guide therapeutic intervention.

title: Incidence of recall, nightmares, and XXXX during analgosedation in intensive care.

answer: @entity1


abstract: BACKGROUND: Catheter @entity4 ( @entity4 ) has a strong correlation with lesion formation during radiofrequency ablation. Delayed-enhancement cardiac magnetic resonance (DE-CMR) provides lesion information in @entity0 with prior @entity2 ( @entity2 ) ablation. OBJECTIVE: The aim of this study was to determine the @entity4 threshold to create permanent lesions detected by DE-CMR. METHODS: A total of 36 @entity0 referred for @entity2 ablation were included. A @entity4 catheter was used during the ablation procedure, and DE-CMR was performed 3 months after the ablation procedure. Eighteen pulmonary vein (PV) segments were defined, and 3-dimensional (3D) reconstructions of the left atrium (LA) derived from the DE-CMR images were obtained. One observer evaluated the presence of any discontinuity of previous ablation lesions (gap) in the 3D reconstructions of the LA, and another observer (blinded to the gap findings) determined the minimum @entity4 value in each PV segment. RESULTS: The PV segments where a gap was observed had a lower maximal @entity4 value than did the segments without gap in the 3D LA reconstructions (6.7    4.4 g vs 12.2    4.7 g; P < .001). In receiver operating characteristic analysis, a @entity4 threshold of >8 g provided 73% sensitivity and 81% specificity in the prediction of a complete @entity1 (positive predictive value [ @entity3 ] 84%). A @entity4 threshold of >12 g had a specificity of 94% and increased the @entity3 to 91% in creating a complete lesion in the LA wall (area under the curve 0.834). CONCLUSION: A @entity4 threshold of >12 g H5H20 predicts a complete lesion with high specificity and @entity3 when a dragging ablation strategy is used in @entity2 ablation.

title: Contact force threshold for permanent lesion formation in XXXX : A cardiac magnetic resonance-based study to detect ablation gaps.

answer: @entity2


abstract: OBJECTIVE: Cereal fiber intake is linked to reduced risk of type 2 @entity0 in epidemiological observations. The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity. RESEARCH DESIGN AND METHODS: A randomized, controlled, single-blind, cross-over study was performed, and 17 overweight or @entity1 subjects with normal @entity2 metabolism were analyzed. After consumption of nine macronutrient-matched portions of fiber-enriched bread (white bread enriched with 31.2 g insoluble fiber/day) or control (white bread) over a time period of 72 h, whole-body insulin sensitivity was assessed by @entity5 . Energy intake was individually adjusted by providing standardized liquid meals. @entity7 breath tests were performed to control for dietary adherence. RESULTS: When analyzing the entire cohort, whole-body @entity2 disposal was improved after fiber consumption (M value 6.56 +/- 0.32 vs. 6.07 +/- 0.27 mg . @entity3 ) . kg(-1); P = 0.043). Thirteen subjects had increased @entity7 breath test concentrations after fiber consumption, indicating probable dietary adherence. Restricting analysis to these subjects, improvements in M value (6.85 +/- 0.34 vs. 6.06 +/- 0.32 mg . @entity3 ) . kg(-1); P = 0.003) and insulin sensitivity, expressed as M/I ratio (M value divided by mean serum insulin at steady state: 3.73 +/- 0.23 vs. 3.21 +/- 0.27; P = 0.02), after fiber consumption were more pronounced. Plasma lipids, serum @entity6 , ghrelin, and @entity4 concentrations, as well as substrate utilization and body weight, were not significantly changed by fiber intake (P > 0.15). CONCLUSIONS: Increased insoluble dietary fiber intake for 3 days significantly improved whole-body insulin sensitivity. These data suggest a potential mechanism linking cereal fiber intake and reduced risk of type 2 @entity0 .

title: Cereal fiber improves whole-body insulin sensitivity in overweight and XXXX women.

answer: @entity1


abstract: Locally advanced colorectal canter may require an intraoperative decision for the block resection of surrounding organs or structures to achieve @entity1 removal. This decision must weigh the risk of complications and @entity3 of multivisceral resection against a potential survival benefit. Little is known about the prognostic factors and their influence on the outcome of multivisceral resection for @entity2 . We demonstrate our experience with multivisceral resections for the primary @entity2 . @entity0 undergoing multivisceral resection for primary @entity4 between I-I.2000-I-VII.2003 were identified from retrospective database. Multivisceral resection was performed in 41 of 378 @entity0 with a median age of 61 years. Postoperative rates of complications and @entity3 in 41 @entity0 were 30.9% and 12.1%. @entity1 infiltration was shown in 58.3% of @entity0 with curative resection. Multivisceral resection is safe, and long-term survival after curative resection is similar to that after standard resection. As the palliative resections cannot be predicted accurately at the time of surgery, every effort should be made to achieve @entity1 resection.

title: [Multivisceral resection in locally advanced XXXX and rectum].

answer: @entity4


abstract: The present clinical trial was undertaken to investigate the @entity1 and antimyeloma activity of @entity4 (BU) and @entity2 (CY) at the maximum tolerated doses of, respectively, 16 mg/kg and 200 mg/kg (BU-CY 4) as conditioning therapy for allogeneic bone marrow transplantation (BMT) in 19 consecutive @entity0 with @entity3 ( @entity3 ). Twelve (63%) had failed to respond to prior chemotherapy, while the remaining 37% had chemosensitive disease. No life-threatening or fatal regimen-related complications were observed. The incidence of @entity5 was zero according to Jones' criteria and 21% according to McDonald's system. Transplant-related mortality was 37%. Using stringent criteria, the frequency of complete remission (CR) was 42% among all @entity0 and 53% among those who could be evaluated. With a median follow-up of 21 months for all @entity0 and 66 months for survivors, the actuarial probability of survival and event-free survival at 4 years from BMT was 26% (95% CI: 7-46) and 21% (95% CI: 3-39), respectively. A more favorable outcome of transplantation was observed in the subgroup of @entity0 with chemosensitive disease who had a transplant-related mortality of 14%, an overall CR rate of 86% (95% CI: 49-97) and a 4-year projected probability of event-free survival of 57% (95% CI: 20-93). Four of these @entity0 are currently alive in continuous CR after 54, 66, 80 and 94 months, respectively. It is concluded that BU-CY 4 as conditioning for allogeneic transplantation for @entity3 is associated with acceptable morbidity and relatively low mortality. This regimen exerts substantial antimyeloma activity, resulting in a high CR rate and durable responses, especially in @entity0 with chemosensitive disease. Long-lasting remission and probable cure is possible following allogeneic stem cell transplantation for @entity3 .

title: High-dose @entity4 and XXXX are an effective conditioning regimen for allogeneic bone marrow transplantation in chemosensitive @entity3 .

answer: @entity2


abstract: OBJECTIVE: Angiogenesis in @entity3 is a prognostic factor associated with @entity3 growth and @entity2 . Studies of angiogenesis in @entity0 showed that neovascularisation correlates with likelihood of @entity2 and recurrence. Our study was to evaluate microvessel density as a prognostic factor in @entity5 . METHODS: Between 1995-1999, 58 @entity1 were treated for @entity5 . The primary treatment consisted of total abdominal hysterectomy, bilateral salpingoophorectomy and pelvic lymphadenectomy. The microscopic examination of @entity4 blocks showed the areas of the deepest myometrial invasion. The microvessels within the invasive @entity3 were highlighted by means of immuno-cytochemical staining to detect @entity6 . RESULTS: Microvessel count was related to likelihood of recurrence. We found statistically significant differences between @entity1 who died after operation and @entity1 with nonrecurrence process. All @entity1 were in the same stage and grade of @entity5 . CONCLUSION: Microvessel density index seems to be an important factor for planing postoperation treatment in @entity5 .

title: [Microvessel density index as a prognostic factor in a low histological differentiation stage of XXXX ].

answer: @entity5


abstract: BACKGROUND: In-vitro studies have suggested that polymorphisms of the @entity4 may influence the desensitisation induced by @entity5 -agonists. We investigated the influence of @entity4 polymorphism on the development of bronchodilator desensitisation in @entity3 @entity0 . METHODS: We carried out an analysis of 22 moderately severe stable asthmatics, mean age 38 years, FEV1 63% of predicted and FEF25-75 38% of predicted, who received a median inhaled corticosteroid dose of 1000 micrograms/day. @entity0 were randomly assigned inhaled placebo or inhaled @entity7 24 micrograms bid for 4 weeks each in a crossover study. Bronchodilator dose-response curves were made at the end of each treatment period by use of cumulative doses of @entity7 (6-108 micrograms) with FEV1 and FEF25-75 measured 30 min after each dose, and up to 6 h after the last dose. We calculated the degree of bronchodilator desensitisation by comparing the dose-response (for maximum and 6 h) after placebo with that after @entity7 , and expressed this degree as a percentage of placebo response. @entity0 were divided into groups according to genotype at codon 16: homozygous @entity2 16 (n = 4), heterozygous @entity2 16/ @entity6 16 (n = 8), and homozygous @entity6 16 (n = 10). At codon 27: homozygous @entity8 27 (n = 5), heterozygous @entity8 27/ @entity1 27 (n = 11), and homozygous @entity1 27 (n = 6). FINDINGS: We found a significantly (p < 0.05) greater degree of bronchodilator desensitisation with homozygous @entity6 16 than with homozygous @entity2 16 for maximal FEV1 response: -8% ( @entity2 16) vs 46% ( @entity6 16); and for maximal FEF25-75 response: -32% ( @entity2 16) vs 74% ( @entity6 16; 95% CI 15-92% and 49-164%, respectively). Bronchodilator responses at 6 h were also significantly (p < 0.05) different for FEV1 and FEF25-75 when @entity2 16 and @entity6 16 were compared and values for heterozygous @entity2 16/ @entity6 16 were intermediate. There was significantly greater desensitisation with @entity1 27 than with @entity8 27 for maximal FEF25-75 response: -7% ( @entity8 27) vs 68% ( @entity1 27), p = 0.05; and for 6 h FEF25-75 response: 43% ( @entity8 27) vs 93% ( @entity1 27), p < 0.05 (95% CI 2-147% and 5-94%, respectively). All @entity0 who were homozygous @entity1 27 were also homozygous @entity6 16. INTERPRETATION: We have found preliminary evidence that @entity4 polymorphism is associated with altered @entity4 expression in @entity3 @entity0 . The homozygous @entity6 -16 form was significantly more prone to bronchodilator desensitisation than @entity2 16, with the influence of @entity6 16 dominating over any putative protective effects of @entity1 27.

title: Association between XXXX polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics.

answer: @entity4


abstract: OBJECTIVE: This study provides prenatal characteristics and postnatal outcomes of @entity0 with severe @entity4 . METHODS: A retrospective analysis of clinical information from cases prenatally diagnosed with severe @entity4 (>90   angulation) in the Fetal Care Center at Cincinnati @entity0 's Hospital Medical Center between 2007 and 2010 was performed. We excluded @entity3 and @entity1 of the head or neck. RESULTS: We identified five @entity0 with severe @entity4 . The fetal spine abnormality was diagnosed between 18 and 27 weeks of gestation. Classical cesarean section was recommended in all @entity0 . There were no immediate airway or neurological complications in the delivery room. @entity2 were present in four of the five @entity0 . These @entity0 had a more complicated clinical course and three separate syndromes including a complex collagenopathy, @entity5 , and @entity6 were identified. One @entity0 had an isolated cervical deformation secondary to a large uterine fibroid with a benign clinical course. None of the @entity0 have required spinal surgery. CONCLUSION: Our @entity0 suggest that connective tissue diseases or @entity5 may be important risk factors for the development of severe @entity4 . There were no significant long-term complications directly related to @entity4 .

title: XXXX in the fetus.

answer: @entity4


abstract: BACKGROUND: @entity3 is a major @entity4 ( @entity4 ) pathogen causing chronic @entity5 and posing a risk for @entity2 between @entity0 with @entity4 . AIM: To propose an algorithm for long-term surveillance of @entity3 and assess its suitability for monitoring the epidemiological situation at a @entity4 centre with approximately 300 @entity0 . METHODS: Over a nine-year period, over 300 @entity3 isolates from 131 infected @entity0 were tested by multi-locus sequence typing (MLST) and/or random amplified polymorphic DNA (RAPD) assay. FINDINGS: MLST analysis led to the identification of 97 different sequence types which were distributed among 17 RAPD-generated (pseudo)clusters. This indicates that the easy-to-perform RAPD assay is only suitable for intra-individual, not interindividual, strain analyses. No epidemic strains were observed. Longitudinal analysis revealed that 110 of the 131 @entity0 were infected with the same strain over the observation period, whereas 21 @entity0 had a strain replacement or a new @entity1 . @entity1 was found in 99 of the 131 @entity0 , and the remaining 32 @entity0 met the criteria for intermittent @entity1 (as defined by the Leeds criteria). Eighteen of the 32 @entity0 (56%) with intermittent @entity1 were infected with the same strain for up to nine years. CONCLUSION: The strain type only changed in 16% of 131 @entity0 with chronic or intermittent @entity1 . As many as 56% of @entity0 considered to have intermittent @entity1 were actually chronically infected with the same strain for many years.

title: How and why to monitor @entity3 XXXX in the long term at a @entity4 centre.

answer: @entity1


abstract: BACKGROUND: Despite being chemosensitive, the majority of @entity0 ( @entity0 ) @entity1 recur. The primary study objectives were to compare disease free survival (DFS), and overall survival (OS) for @entity0 after adjuvant chemotherapy, who underwent maintenance metronomic chemotherapy versus no maintenance therapy. METHODS: @entity0 @entity1 were eligible for enrolment if they had TNM stages II-III and fit with our inclusion criteria. @entity1 were assigned to either: group 1, 3 cycles FEC-100 then 3 cycles @entity3 , @entity4 , followed by maintenance metronomic chemotherapy for 1 year; and group 2, 3 cycles FEC-100 then 3 cycles @entity3 . RESULTS: Between November 2008 and December 2014, 158 @entity1 (78 group 1, and 80 group 2) were enrolled. The mean age was 46 years. The median DFS for groups 1,2 were 28 and 24 months, respectively; P value 0.05. The median OS for groups 1,2 were 37 and 29 months, respectively; P values 0.04. Additionally, during the follow-up period, the overall distant metastasis recurrence rates for groups 1,2 were 26% and 37% respectively. Finally, treatment protocol was tolerated well in both groups with mild @entity2 profiles. CONCLUSIONS: Extended adjuvant metronomic chemotherapy achieved significant improvement in the survival and was well tolerated.

title: Metronomic methotrexate and cyclophosphamide after @entity4 included adjuvant chemotherapy in XXXX : a phase III study.

answer: @entity0