abstract: BACKGROUND: Partial duplication of 2p is a rare condition that causes @entity1 , @entity4 , and @entity3 . Hypercalcaemia is rare in @entity0 . So far, duplication of 2p has never been associated with hypercalcaemia. METHODS: Here, we report a @entity0 with a partial duplication of 2p presenting with moderate to severe hypercalcaemia at the age of 2 years. She also had @entity8 , @entity11 , @entity2 , and secondary @entity6 at presentation. She was thoroughly investigated, including genetic testing of the @entity13 , @entity5 , ALPL, and @entity9 genes, to determine the cause of hypercalcaemia. RESULTS: @entity10 levels were increased. Hypercalcaemia and @entity8 responded well to glucocorticoids but not to @entity7 . @entity6 resolved with improving renal function. Apart from the known duplication of 2p, no pathogenic variants were detected in the studied genes. The duplication of 2p contains the @entity14 gene, which encodes for the @entity14 subunit. CONCLUSION: We conclude that partial duplication of 2p can be associated with hypercalcaemia and @entity8 and hypothesise that the underlying mechanism is an increased extra-renal, parathyroid hormone-independent @entity12 1a-hydroxylase activity, leading to raised amounts of @entity10 . The increased enzymatic activity could possibly be caused by @entity14 subunit-related macrophage stimulation.

title: Hypercalcaemia in a XXXX with 2p13.2-p16.1 Duplication.

answer: @entity0


abstract: Spinal fusion is used to treat @entity4 in @entity0 with @entity2 ( @entity2 ). Following intervention, the WHO considers activity and participation should be assessed to guide intervention and assess the effects. This study assesses whether spinal fusion for @entity4 improves activity and participation for @entity0 with severe @entity2 .Retrospective cohort study of 70 @entity0 (39M:31F) with GMFCS level 4/5 @entity2 and significant @entity4 . Thirty-six underwent observational and/or brace treatment as the sole treatment for their @entity4 , and 34 underwent surgery. @entity0 in the operative group were older and had worse @entity4 than those in the observational group. Questionnaire and radiographic data were recorded over a 2-year period. The ASKp was used to measure activity and participation.In the observational group, Cobb angle and @entity3 increased from 51 (40-90) and 10 (0-30) to 70 (43-111) and 14 (0-37). Mean ASKp decreased from 16.3 (1-38) to 14.2 (1-36). In the operative group, Cobb angle and @entity3 decreased from 81 (50-131) and 14 (1-35) to 38 (10-76) and 9 (0-24). Mean ASKp increased from 10.5 (0-29) to 15.9 (3-38). Spinal-related @entity1 correlated most with change in activity and participation in both groups. There was no difference in mobility, GMFCS level, feeding or communication in either group before and after treatment.In @entity0 with significant @entity4 and @entity2 classified within GMFCS levels 4 and 5, spinal fusion was associated with an improvement in activity and participation, whereas nonoperative treatment was associated with a small reduction. @entity1 should be carefully assessed to guide intervention.

title: Does Spinal Fusion and Scoliosis Correction Improve Activity and Participation for @entity0 With GMFCS level 4 and 5 XXXX ?

answer: @entity2


abstract: @entity8 ( @entity8 ) is a catalytic inhibitor of the nuclear enzyme DNA topoisomerase II (topo II). It protects cells against topo II poisons, such as @entity5 and @entity4 , by hindering the DNA cleavage reaction of the target enzyme. We have previously shown that this antagonism also extends to an in vivo model. Thus, @entity8 protected @entity1 against supralethal doses of @entity5 and @entity7 , and the @entity5 LD10 dose increased as much as 3.6-fold when combined with @entity8 (B. Holm, Cancer Chemother. Pharmacol., 38: 203-209, 1996). We describe here how scheduling of this drug combination can be optimized and used. Interestingly, @entity8 can protect when it is given after @entity5 . Although timing is very critical here, @entity8 was able to completely protect when given 10 min after @entity5 . This rescue principle resembles methotrexate rescue by @entity6 . We also found scheduling to be crucial because @entity8 did not protect when @entity5 was given once a day for five days, whereas effective protection was seen when @entity5 was used three times, once every four days. Similar investigations were performed with @entity4 in combination with @entity8 . The combination with @entity8 allowed a 3.4-fold @entity4 dose escalation. Such dose escalations could be advantageous in specific situations. One such case is when the @entity0 is situated in a pharmacological sanctuary, e.g., in the brain. @entity8 is hydrophilic and does not cross the blood-brain barrier, whereas the lipophilic @entity5 and @entity4 do. Therefore, @entity8 would protect normal tissues and allow a cytotoxic dose of @entity5 to reach the central nervous system (CNS). We therefore studied the combinations using L1210 or EHR2 cells inoculated into the CNS of @entity1 . L1210 presented a leukemic CNS model with leptomeningeal spread and infiltration of liver, spleen, and lymph nodes, whereas EHR2 cells acted as a solid @entity0 with no evidence of @entity2 . In all experiments, the combination of high-dose @entity5 and @entity8 was significantly superior to an equitoxic dose of @entity5 alone. Such superiority was also seen when treatment was given on days 4, 8, and 12 after @entity0 inoculation. Here @entity5 alone resulted in a mean increased life span of 12.3%, whereas the rescue regimen yielded an increase of 47% (P < 0.0001). In conclusion, DNA topo II rescue by catalytic inhibitors is a new strategy enabling significant epipodophyllotoxin dose escalations; in this study, we have demonstrated the superiority of this strategy in two in vivo @entity3 models. This concept is now being tested in a clinical trial.

title: Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of XXXX and @entity4 .

answer: @entity5


abstract: BACKGROUND: Recurrence of transitional cell @entity1 cannot be predicted accurately by traditional criteria alone. This study examined the value of cell proliferative activity, morphometry, and expression of @entity5 , @entity8 , and @entity4 oncogenes in predicting recurrence of superficial papillary urothelial neoplasms of low malignant potential (LMP) and Grade 1 (G1) @entity7 of the bladder. METHODS: Sixty-two @entity0 (mean age, 62 years) with newly diagnosed superficial pTa @entity1 (19 LMP, and 43 G1) were analyzed retrospectively. All @entity0 underwent transurethral resection (TUR). Median follow-up was 69 months. Serial sections from @entity3 -fixed, @entity6 -embedded material at initial TUR were stained with monoclonal antibodies (MoAbs) DO7, CB11, and @entity4 -124. Cell proliferation was assessed by @entity9 MoAb, the quantity of argyrophilic nucleolar organizer region-associated proteins (AgNORs), and mitotic count. RESULTS: Of the 62 @entity0 , 42 (67.7%) had one or more recurrences. Recurrence rates were higher in @entity9 (P < 0.0001) and @entity5 immunopositive cases (P = 0.02), when the mitotic count was greater than 5 (P = 0.004), and in G1 @entity2 (P = 0.04). In univariate analysis, the disease-free period was shorter for @entity9 (P < 0.0001) and @entity5 immunopositive (P = 0.0001) cases, for cases with high AgNOR quantity (P = 0.04), mitotic count greater than 5 (P = 0.01), and in G1 @entity2 (P = 0.002). In multivariate analysis, only @entity9 immunoreactivity retained independent prognostic significance. CONCLUSIONS: Despite the small cohort, the results confirm the prognostic value of cell proliferation and @entity5 expression in @entity0 with @entity1 . The results also indicate that @entity9 immunopositivity is the most significant predictor of recurrence and disease-free survival in superficial LMP and G1 @entity1 .

title: Proliferative activity is the most significant predictor of recurrence in noninvasive papillary urothelial neoplasms of low malignant potential and grade 1 XXXX of the bladder.

answer: @entity7


abstract: UNASSIGNED: Vesicular transporter proteins are an essential component of the presynaptic machinery that regulates neurotransmitter storage and release. They also provide a key point of control for homeostatic signaling pathways that maintain balanced excitation and inhibition following changes in activity levels, including the onset of sensory experience. To advance understanding of their roles in the developing auditory forebrain, we tracked the expression of the vesicular transporters of @entity2 ( @entity6 , @entity8 ) and @entity1 ( @entity7 ) in primary auditory cortex (A1) and medial geniculate body (MGB) of developing @entity0 (P7, @entity5 , @entity3 , @entity4 , adult) before and after ear canal opening (~ @entity5 -P13). RNA sequencing, in situ hybridization, and immunohistochemistry were combined to track changes in transporter expression and document regional patterns of transcript and protein localization. Overall, vesicular transporter expression changed the most between P7 and @entity4 . The expression patterns and maturational trajectories of each marker varied by brain region, cortical layer, and MGB subdivision. @entity6 expression was highest in A1, moderate in MGB, and increased with age in both regions. @entity8 mRNA levels were low in A1 at all ages, but high in MGB, where adult levels were reached by @entity3 . @entity8 immunoreactivity was prominent in both regions. @entity6 (+) and @entity8 (+) transcripts were co-expressed in MGB and A1 somata, but co-localization of immunoreactive puncta was not detected. In A1, @entity7 mRNA levels were relatively stable from P7 to adult, while immunoreactivity increased steadily. @entity7 (+) transcripts were rare in MGB neurons, whereas @entity7 immunoreactivity was robust at all ages. Morphological changes in immunoreactive puncta were found in two regions after ear canal opening. In the ventral MGB, a decrease in @entity8 puncta density was accompanied by an increase in puncta size. In A1, perisomatic @entity7 and @entity6 terminals became prominent around the neuronal somata. Overall, the observed changes in gene and protein expression, regional architecture, and morphology relate to-and to some extent may enable-the emergence of mature sound-evoked activity patterns. In that regard, the findings of this study expand our understanding of the presynaptic mechanisms that regulate critical period formation associated with experience-dependent refinement of sound processing in auditory forebrain circuits.

title: Differential maturation of vesicular XXXX and @entity1 transporter expression in the @entity0 auditory forebrain during the first weeks of hearing.

answer: @entity2


abstract: PURPOSE: The clinical significance of preoperative serum levels of carcinoembryonic antigen ( @entity3 ) and @entity2 antigen 15-3 ( @entity5 ) in @entity0 is controversial. The purpose of this study was to assess the clinical value of preoperative serum levels of @entity3 and @entity5 on the risk of @entity4 ( @entity4 ) in @entity1 with @entity0 . METHODS: This retrospective study analyzed 1148 @entity0 @entity1 whose preoperative @entity3 and @entity5 levels were measured. The association of these @entity2 markers and clinicopathologic parameters with @entity4 was determined by univariate and multivariate analysis. RESULTS: A median of 15 lymph nodes were removed. Seven hundred seventy-eight (67.8%) @entity1 had node-negative disease and 370 (32.2%) had @entity4 . Univariate analysis showed that @entity2 location (P = 0.024), stage (P = 0.001), grade (P < 0.001), lymphovascular invasion (LVI) (P < 0.001), @entity3 level (P < 0.001), @entity5 level (P < 0.001), and @entity0 subtype (BCS) (P < 0.001) were significantly associated with @entity4 . @entity4 was present in 4.5% of @entity1 with normal @entity3 and 11.6% of @entity1 with elevated @entity3 . @entity4 was present in 8.0% of @entity1 with normal @entity5 and 17.0% of @entity1 with high @entity5 . Multivariate logistic regression analysis showed that @entity2 location, stage, grade, LVI, @entity3 , @entity5 , and BCS were significantly and independently associated with @entity4 (P < 0.05 for all). CONCLUSION: The probability of @entity4 was greater in @entity1 with elevated preoperative serum levels of @entity3 and @entity5 . @entity3 and @entity5 appear to be independent predictors of @entity4 in @entity0 .

title: Use of XXXX and @entity5 to Predict Axillary Lymph Node Metastasis in @entity1 with @entity0 .

answer: @entity3


abstract: Family history of @entity2 has been associated with an increased risk of @entity4 ( @entity4 ). It is uncertain whether this risk is mediated by familial aggregation of risk factors for @entity4 , such as @entity1 and @entity3 . The association of @entity4 with @entity2 was examined in a large, population-based case-control study conducted in Maryland, Virginia, @entity5 , and Washington, DC. The number of first-degree relatives who were affected with any @entity2 was compared between 689 newly treated @entity4 @entity0 registered in the Medicare @entity4 program (92% of all eligible incident cases presenting between January and July of 1991) and 361 control subjects without @entity4 who were selected by random-digit dialing (90% response rate). @entity0 and control subjects were frequency matched by age; @entity0 with @entity4 caused by @entity2 and other known @entity2 were excluded. Analysis was conducted using multiple logistic regression. After controlling for the proband's age, gender, race, family size, socioeconomic status, and personal and family histories of @entity1 and @entity3 , having one first-degree relative with @entity2 increased the odds of @entity4 by 1.3 (95% confidence interval, 0.7 to 2.6) and having two or more affected first-degree relatives increased the odds of @entity4 by 10.4 (95% confidence interval, 2.7 to 40.2). These data support @entity2 in excess of that predicted by clustering of @entity1 and @entity3 within families, suggesting that either genetic susceptibility or environmental exposures shared within families increase the risk of developing @entity4 . This risk is also much higher when two or more first-degree relatives have @entity2 . Unraveling the molecular basis of this increase in risk may provide new avenues for treatment and prevention of @entity4 .

title: Familial aggregation of XXXX in a population-based case-control study.

answer: @entity2


abstract: OBJECTIVES: Cardiac computed tomography perfusion (CTP) using stress testing is an emerging application in the field of cardiac computed tomography. We evaluated @entity0 with acute @entity3 ( @entity3 ) in the @entity1 ( @entity1 ) with evidence of obstructive @entity2 ( @entity2 ), defined as >70% @entity4 on coronary computed tomography angiography (CCTA) and confirmed by invasive coronary angiography (ICA), to evaluate the applicability of resting CTP in the acute @entity3 setting. METHODS: From January to December 2013, 183 low-intermediate risk symptomatic @entity0 with negative cardiac biomarkers and no known @entity2 underwent a rapid CCTA protocol in the @entity1 . Of these, 4 @entity0 (1.4%) had obstructive @entity2 (>= 70% @entity4 ) on CCTA confirmed by ICA. All 183 CCTA studies were evaluated retrospectively with CTP software by a transmural perfusion ratio (TPR) method with a superimposed 17-segment model. A TPR value <0.99 was considered abnormal based on previously published data. RESULTS: A total of four @entity0 were included in this pilot analysis. The duration from resolution of @entity3 to performance of CCTA ranged from 1.6 to 5.0 hours. Three @entity0 underwent revascularization, two with percutaneous coronary intervention (PCI) and one with coronary artery bypass grafting. The fourth @entity0 was managed with aggressive medical therapy. Two @entity0 had multivessel obstructive @entity2 and two @entity0 had @entity2 . The first @entity0 underwent CCTA 5 hours after resolution of @entity3 symptoms. CCTA demonstrated noncalcified obstructive @entity2 in the mid- @entity5 and mid-right coronary artery. ICA showed good correlation by quantitative coronary assessment (QCA) in both vessels and the @entity0 underwent PCI. CTP analysis demonstrated perfusion defects in the @entity5 and right coronary artery territories. The second @entity0 underwent CCTA 1.6 hours after resolution of @entity3 symptoms with findings of obstructive ostial left main @entity2 . ICA confirmed obstructive left main @entity2 by QCA and intravascular ultrasound. The @entity0 underwent revascularization with coronary artery bypass grafting. CTP demonstrated perfusion defects in the anterior and lateral wall segments. The third @entity0 was evaluated for @entity3 in the @entity1 with CCTA demonstrating @entity2 10 hours after resolution of symptoms with findings of a @entity4 in the mid- @entity5 . The @entity0 subsequently underwent ICA demonstrating good correlation to the CCTA findings in the @entity5 by QCA. CTP analysis revealed perfusion defects in @entity5 territory. He was successful treated with PCI. The final @entity0 underwent CCTA 5.4 hours following resolution of @entity3 with the finding of an intermediate partially calcified @entity4 in the distal @entity5 . ICA was performed, with fractional flow reserve demonstrating a hemodynamically insignificant distal @entity5 at 0.86. CTP detected a perfusion defect in the @entity5 territory. CONCLUSIONS: When positive, rest CTP may have value in the risk stratification of @entity0 presenting to the @entity1 with nontraumatic acute @entity3 .

title: Rest-Only Myocardial CT Perfusion in Acute XXXX .

answer: @entity3


abstract: OBJECTIVE: This study aims to document and analyze the central venous catheter (CVC)-related complications in @entity0 with @entity6 who were treated within a single institution. MATERIALS AND METHODS: A retrospective investigation was conducted in 106 pediatric @entity0 in whom 203 CVCs were inserted. A total of 175 catheter-related complications occurred in 5 years. RESULTS: The rates of clinical @entity4 , local @entity4 , @entity3 , @entity1 , and mechanical complications were 2.6, 1.1, 0.2, 0.2, and 0.2 per 1000 catheter days. @entity8 -resistant @entity9 was the predominant infectious organism in blood and catheter cultures. The @entity0 with @entity7 had a significantly higher frequency of clinical @entity4 (p=0.046). The @entity0 who underwent bone marrow transplantation had a significantly lower frequency of clinical @entity4 (p=0.043) and higher frequency of local @entity4 (p=0.003). The @entity0 with implanted catheters had a significantly lower frequency of clinical @entity4 (p=0.048). The @entity0 with @entity2 had significantly fewer local @entity4 and significantly more clinical @entity4 and catheter-related @entity1 (respectively p=0.001, p=0.042, and p=0.024). CONCLUSION: @entity7 , bone marrow transplantation, and @entity2 are risk factors for CVC-associated complications. The relatively higher number of interventions performed via permanent catheters may be responsible for the significantly increased incidence of @entity5 .

title: Cohort Study: Central Venous Catheter-Related Complications in @entity0 with XXXX at a Single Center.

answer: @entity6


abstract: Assessment of suicide enzyme activity would have considerable impact on the planning and the individualization of suicide gene therapy of @entity1 . This may be done by determining the pharmacokinetics of specific substrates. We generated @entity5 (GCV)-sensitive @entity0 @entity2 cell lines after transfection with a retroviral vector bearing the herpes simplex virus @entity3 kinase (HSV-tk) gene. Thereafter, uptake measurements and HPLC analyses were performed up to 48 h in an HSV-tk-expressing cell line and in a wild-type cell line using tritiated GCV. HSV-tk-expressing cells showed higher GCV uptake and phosphorylation than control cells, whereas in wild-type MCF7 cells no phosphorylated GCV was detected. In bystander experiments the total GCV uptake was related to the amount of HSV-tk-expressing cells. Furthermore, the uptake of GCV correlated closely with the growth inhibition (r = 0.92). Therefore, the accumulation of specific substrates may serve as an indicator of the HSV-tk activity and of therapy outcome. Inhibition and competition experiments demonstrated slow transport of GCV by the @entity4 carriers. The slow uptake and low affinity to HSV-tk indicate that GCV is not an ideal substrate for the @entity4 transport systems or for HSV-tk. This may be the limiting factor for therapy success, necessitating the search for better substrates of HSV-tk.

title: @entity5 uptake in XXXX @entity2 cells expressing herpes simplex virus @entity3 kinase.

answer: @entity0


abstract: OBJECTIVE: To compare peri-operative complications, @entity2 , and the immediate functional results of the sub-urethral sling procedure for @entity7 by the retropublic and transobturator routes, using a non-elastic @entity8 sub-urethral sling. @entity0 AND METHODS: This prospective, multicentre study involved 88 @entity0 undergoing the sub-urethral sling procedure for stress @entity3 (SUI). The retropubic route (RPR) and the transobturator route (TOR) were used in respectively 42 and 46 cases. The characteristics of the @entity0 in the RPR and TOR groups were as follows: mean age (+/-standard deviation) 56.8+/-12 years and 53.4+/-10 years, respectively; mean BMI: 25+/-4 and 26+/-4; mean parity: 2.1+/-0.9 and 2+/-1 @entity0 ; post-menopausal status: 66.7% and 58.7%; prior surgery for SUI: 7.1% and 6.5%; and prior hysterectomy: 21.4% and 26.1%. None of these characteristics differed significantly between the groups. Likewise, pre-operative urinary functional status (SUI stage, and pollakiuria, @entity6 and urgency rates) was similar in the two groups. RESULTS: Mean hospital stay and overall morbidity rate were not significantly different between the RPR and TOR groups. Mean operating time was longer in the RPR group. @entity5 was significantly more frequent in the RPR group and @entity1 was significantly more frequent in the TOR group. @entity2 scores were significantly lower in the TOR group. The objective functional results at one month did not differ between the groups. Quality of life, evaluated with questionnaires and numerical rating scales, was similarly improved in the two groups. DISCUSSION: The suburethral sling procedure was less painful by the TOR route than by the RPR route. @entity5 , haematomas and @entity4 were only observed in the RPR group, while @entity1 only occurred in the TOR group. The immediate functional results of the two approaches were similar.

title: Peri-operative complications and XXXX after the suburethral sling procedure for @entity7 : a French prospective randomised multicentre study comparing the retropubic and transobturator routes.

answer: @entity2


abstract: Background. @entity3 can acutely activate various inflammatory transcription factors. Since high levels of oxyradicals and lower antioxidant levels in septic @entity0 are believed to result in @entity1 , @entity3 levels could be used as a marker of oxidative stress and poor prognosis in @entity0 with @entity2 . Design. We conducted a prospective cohort study on Medical Intensive Care Unit (MICU) @entity0 and hypothesized that elevated @entity3 in @entity0 with @entity2 is predictive of greater morbidity. The primary end point was the correlation between @entity6 and the morbidity rate. Secondary end points were @entity5 ( @entity5 ), mortality, @entity4 ( @entity4 ), and duration of stay. Results. We enrolled 144 @entity0 . 54 (37.5%) had the primary end point of @entity6 . The overall morbidity rate was 85.2%. The probability of having @entity6 along with @entity5 was 68.5% and without @entity5 was 31.5%. Meanwhile the probability of having a @entity3 value <7   mg/dL along with @entity5 was 18.9% and without @entity5 was 81.1% (p value < 0.0001). Conclusion. We report that elevated @entity3 levels on arrival to the MICU in @entity0 with @entity2 are associated with poor prognosis. These @entity0 are at an increased risk for @entity5 and @entity4 .

title: XXXX : An Early Marker for Severity of Illness in @entity2 .

answer: @entity6


abstract: BACKGROUND: Esophageal stricture due to caustic ingestion is one of the most difficult problems to manage. Esophageal dilations are the usual treatment and they require a great number of sessions in the majority of cases. This implies time, risks for the @entity0 , anguish for the relatives, and very often, frustration for the physician. OBJECTIVES: To evaluate the efficacy of the application of topical @entity2 and intralesional @entity4 in the prevention of post-dilation esophageal stricture recurrence. MATERIAL AND METHODS: A prospective, comparative, nonrandomized, and longitudinal study was conducted that compared a cohort of 16 @entity0 treated with @entity2 (2009-2012) with a retrospective cohort of 34 @entity0 treated with @entity4 (2002-2009). RESULTS: The @entity0 treated with intralesional @entity4 had a median of 11 dilations (minimum 4 and maximum 24), whereas the median in the @entity0 treated with topical @entity2 was 4.5 (minimum 3 and maximum 8). The groups were compared using the Mann-Whitney U test, finding a statistically significant difference of a two-tailed P<.001. In the multiple linear regression model, the dependent variable was the number of dilations and the independent variables were the @entity1 and treatment. The result was an R(2) .676 with a significance level of P<.001, in which the regression coefficient for treatment was B -.682 (95% CI -8.286 to -5.025) and the lesion grade was B .435 (95% CI 2.043- 4.573). The ANOVA result was an F 49.08 and a P<.001 and showed that the independent variables of @entity1 and treatment had a linear relation with the number of dilations, reinforcing the fact that our results were not due to chance. CONCLUSIONS: Topical @entity2 considerably reduced the number of esophageal dilations compared with the use of intralesional @entity4 to alleviate @entity3 , and therefore we suggest it as a treatment option in strictures due to caustic ingestion.

title: Topical XXXX versus intralesional @entity4 in the management of esophageal stricture due to caustic ingestion.

answer: @entity2


abstract: Mutations in the @entity7 gene cause the severe @entity4 called @entity6 . Preliminary evidence suggests that @entity7 may be involved in a broader phenotype than classical @entity6 including preserved speech variants (PSV). Here we report clinical and mutation analysis of 18 PSV @entity0 . Ten of them had a @entity7 mutation (55%). The clinical features of these @entity0 have been characterized and two subgroups defined. All of them had slow recovery of verbal and praxic abilities, evident @entity3 , and normal head circumference. Six were overweight, often @entity1 , had @entity5 , coarse face, and mental age of two-to-three years, and were able to speak in sentences; four had normal weight, mental age not beyond one-to-two years, and spoke in single words and two-word phrases. The @entity2 was in stages as in classic @entity6 . Hand-washing was present in the first years of life but often subsequently disappeared. Significantly, all mutations found in PSV are either missense or late truncating mutations. In particular, we did not find the four early truncating hot spots: @entity9 , @entity10 , @entity11 , @entity8 . These results suggest that early truncating mutations lead to a poor prognosis (classic Rett), while late truncating and missense mutations lead either to classic Rett or PSV. We hypothesize that a missense or late truncating mutation is necessary but not sufficient to produce a PSV, based on the presence of one (or more) modifier genes whose product may interact in a epistatic manner with @entity7 protein.

title: Preserved speech variants of the XXXX : molecular and clinical analysis.

answer: @entity6


abstract: OBJECTIVE: The aim of this study was to evaluate the influence of BMI on @entity3 in average-risk @entity0 aged between 40 and 59 years, analyzed by sex. METHODS: A total of 4443 @entity0 aged between 40 and 59 years undergoing a first-time screening or average-risk colonoscopy were included in this study. Data on demographics, smoking, and BMI were collected and correlated to the presence of @entity2 and advanced @entity2 . RESULTS: We evaluated 1197 colonoscopies in @entity0 aged between 40 and 49 years, and 3246 in those aged between 50 and 59 years. Among @entity0 between 40 and 49 years, increasing BMI [odds ratio (OR)=1.05, 95% confidence interval (CI): 1.00-1.09] and BMI of at least 27 (OR=1.95, 95% CI: 1.15-3.29) were predictors of @entity2 . Younger @entity0 with a BMI of at least 27 were more likely to have proximal @entity2 (OR=2.23, 95% CI: 1.14-4.37) but not advanced @entity2 . There was no relation between BMI and @entity2 in younger @entity0 . Among @entity0 aged between 50 and 59 years, increasing BMI (OR=1.03, 95% CI: 1.01-1.05) and a BMI of at least 24 (OR=1.43, 95% CI: 1.06-2.94) was found to be correlated with @entity2 , and increasing BMI was also found to be associated with proximal @entity2 (OR=1.67, 95% CI: 1.13-2.45). Among @entity0 aged between 50 and 59 years, there was no relation between BMI and @entity2 , but there was a positive correlation for advanced @entity2 (OR=1.05, 95% CI: 1.002-1.09). Among @entity0 aged between 50 and 59 years, BMI was not predictive of advanced @entity2 . CONCLUSION: The association between BMI and @entity2 differs by age and sex. If BMI is utilized to refine screening practices for @entity1 , its influence on sex and age should be taken into account.

title: Can adjusting BMI for age and sex provide for a better predictor of XXXX ?

answer: @entity3


abstract: UNASSIGNED: Surgical correction for @entity6 is increasingly being performed for @entity0 with @entity4 ( @entity4 ). Reported case series have predominantly included @entity0 with Type I (Hurler) and Type IV (Morquio) @entity4 . To their knowledge, the authors describe the first case report of surgical management of thoracolumbar @entity6 in @entity8 ( @entity4 Type II) and the rare occurrence of @entity10 following surgical stabilization. A 12-year-old @entity0 with @entity8 presented with severe thoracolumbar @entity6 and no associated symptoms. Spinal radiographs demonstrated @entity2 of 48   (T11-L3) and @entity3 of 22   (T11-L3) with an anteriorly hypoplastic @entity7 vertebra. The @entity1 progressed to @entity2 of 60   and @entity3 of 42   prior to surgical intervention. Spinal CT scans identified left T12-L1 facet subluxation, causing anterior rotatory displacement of the spine proximal to @entity7 isthmic spondylolysis with no spondylolisthesis. A combined single-stage anterior and posterior instrumented spinal arthrodesis from T-9 to @entity9 was performed. @entity2 and @entity3 were corrected to 4   and 0  , respectively. Prolonged ventilator support and nasogastric feedings were required for 3 months postoperatively. At 2.5 years following surgery, the @entity0 was asymptomatic, mobilizing independently, and had achieved a solid spinal fusion. However, he had also developed a Grade II spondylolisthesis at L4-5; this was managed nonoperatively in the absence of symptoms or further deterioration of the spondylolisthesis to the 3.5-year postoperative follow-up visit. Satisfactory correction of thoracolumbar @entity6 in @entity8 can be achieved by combined anterior/posterior instrumented arthrodesis. The risk of developing @entity1 or instability in motion segments adjacent to an instrumented fusion may be greater in @entity0 with @entity4 related to the underlying @entity5 .

title: Thoracolumbar XXXX with unilateral subluxation of the spine and postoperative @entity10 in @entity8 .

answer: @entity6


abstract: BACKGROUND: This study was performed to find the optimal volume of local anesthetics needed for a successful ultrasound-guided stellate ganglion block (SGB) to treat head and neck pathology. METHODS: Fifteen female and fourteen male @entity1 @entity0 received 4 times SGBs with 0.2% @entity2 in volumes of 6, 4, 3 and 2 ml at 1 to 3 day intervals. Using the transverse short-axis view of the neck that showed Chassaignac's tubercle at the C6 level, a 25-gauge, and 4 cm needle was inserted via the lateral paracarotid approach with out-of-plane targeting between the prevertebral fascia and the ventral surface of longus colli muscle (subfascial injection). A successful block was confirmed with the onset of @entity3 ( @entity4 ). RESULTS: There were no significant statistical differences between the presence of @entity4 and the volume of local anesthetics given. However, @entity4 was present in all trials for the 4 ml and 6 ml groups. Six (20.7%) and three out (10.4%) of twenty-nine trials in the 2 ml and 3 ml groups, respectively, failed to elicit @entity4 . The duration of action was significantly different in the 2 ml group compared to that of the 6 ml group, but there was no significant difference between the other groups, including the 4 ml vs. 6 ml groups. The side effects were not different between the groups. CONCLUSIONS: This data suggests that the optimal volume of 0.2% @entity2 for ultrasound-guided SGB to treat the head and neck pathology in daily practice is 4 ml.

title: The optimal volume of 0.2% XXXX required for an ultrasound-guided stellate ganglion block.

answer: @entity2


abstract: OBJECTIVE: To investigate the feasibility, acceptability and potential efficacy of group exercise for residents in care homes. DESIGN: Exploratory cluster randomized controlled trial. SETTING: Five randomly selected care homes in South Birmingham, UK. @entity0 : Fifty-six care home residents (mean age 84.5, 71% female), 39 (70%) with @entity2 . INTERVENTION: Two homes (n = 28) were randomized to group exercise held twice weekly for five weeks. The remaining three homes (n = 28) formed the control group and received usual care, with no @entity0 specifically responsible for exercise training. OUTCOME MEASURES: Assessments were conducted at zero (pre-intervention), three (post-intervention) and six months (follow-up) using the Rivermead Mobility Index and Hospital Anxiety and @entity3 Scale or @entity1 Aphasic @entity3 Questionnaire (depending on @entity2 ). Adherence to group exercise and retention to the study were also documented. RESULTS: No statistically significant improvements in mobility or @entity3 were found in favour of group exercise. Retention to the study was high with 46 (82%) @entity0 completing all assessments. Adherence to group exercise was somewhat lower with @entity0 attending a mean of 3.61 out of 8.5 prescribed sessions (42.5%). CONCLUSIONS: Group exercise can be delivered to care home residents with reduced mobility but it is not suitable for residents with severe @entity2 . An estimated sample size of 240 @entity0 would be required to detect a clinically significant difference in the Rivermead Mobility Index with 90% power.

title: An exploratory cluster randomized controlled trial of group exercise on mobility and XXXX in care home residents.

answer: @entity3


abstract: PURPOSE: This study evaluated the setup uncertainties for brain sites when using BrainLAB's ExacTrac X- @entity3 6D system for daily pretreatment to determine the optimal planning target volume ( @entity1 ) margin. METHODS: Between August 2012 and April 2015, 28 @entity0 with @entity2 were treated by daily image-guided radiotherapy using the BrainLAB ExacTrac 6D image guidance system of the Novalis-Tx linear accelerator. DUONTM (Orfit Industries, Wijnegem, Belgium) masks were used to fix the head. The radiotherapy was fractionated into 27-33 treatments. In total, 844 image verifications were performed for 28 @entity0 and used for the analysis. The setup corrections along with the systematic and random errors were analyzed for six degrees of freedom in the translational (lateral, longitudinal, and vertical) and rotational (pitch, roll, and yaw) dimensions. RESULTS: Optimal @entity1 margins were calculated based on van Herk et al.'s [margin recipe = 2.5  - + 0.7   - 3 mm] and Stroom et al.'s [margin recipe = 2  - + 0.7  ] formulas. The systematic errors (  -) were 0.72, 1.57, and 0.97 mm in the lateral, longitudinal, and vertical translational dimensions, respectively, and 0.72  , 0.87  , and 0.83   in the pitch, roll, and yaw rotational dimensions, respectively. The random errors (  ) were 0.31, 0.46, and 0.54 mm in the lateral, longitudinal, and vertical rotational dimensions, respectively, and 0.28  , 0.24  , and 0.31   in the pitch, roll, and yaw rotational dimensions, respectively. According to van Herk et al.'s and Stroom et al.'s recipes, the recommended lateral @entity1 margins were 0.97 and 1.66 mm, respectively; the longitudinal margins were 1.26 and 3.47 mm, respectively; and the vertical margins were 0.21 and 2.31 mm, respectively. CONCLUSION: Therefore, daily setup verifications using the BrainLAB ExacTrac 6D image guide system are very useful for evaluating the setup uncertainties and determining the setup margin.  -  .

title: SU-F-J-24: Setup Uncertainty and Margin of the ExacTrac 6D Image Guide System for XXXX with @entity2 .

answer: @entity0


abstract: OBJECTIVE: To examine cognitive function in individuals with @entity1 ( @entity1 ) prior to and after participation in an aerobic exercise training program. DESIGN: Pre-post intervention study. SETTING: Medical research center. @entity0 : Volunteer sample of individuals (N=7) (age, 33.3  7.9y) with chronic nonpenetrating @entity1 (injury severity: 3=mild, 4=moderate; time since most current injury: 4.0  5.5y) who were ambulatory. INTERVENTION: Twelve weeks of supervised vigorous aerobic exercise training performed 3 times a week for 30 minutes on a treadmill. MAIN OUTCOME MEASURES: Cognitive function was assessed using the Trail Making Test Part A (TMT-A), Trail Making Test Part B (TMT-B), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sleep quality and @entity2 were measured with the Pittsburgh Sleep Quality Index (PSQI) and Beck Depression Inventory, version 2 (BDI-II). Indices of @entity3 were used to examine the relation between improvements in cognitive function and @entity3 . RESULTS: After training, improvements in cognitive function were observed with greater scores on the TMT-A (10.3  6.8; P=.007), TMT-B (9.6  7.0; P=.011), and RBANS total scale (13.3  9.3; P=.009). No changes were observed in measures of the PSQI and BDI-II. The magnitude of cognitive improvements was also strongly related to the gains in @entity3 . CONCLUSIONS: These findings suggest that vigorous aerobic exercise training may improve specific aspects of cognitive function in individuals with @entity1 and @entity3 may be a determinant of these improvements.

title: Improved cognitive performance following aerobic exercise training in XXXX with @entity1 .

answer: @entity0


abstract: UNASSIGNED: Correct positioning and differentiation of neurons during brain development is a key precondition for proper function. @entity6 ( @entity6 ) are increasingly recognized as causes of therapy refractory @entity2 . Neuropathological analyses of respective surgical specimens from neurosurgery for @entity3 control often reveal aberrant cortical architecture and/or aberrantly shaped neurons in @entity6 . However, the molecular pathogenesis particularly of @entity6 with aberrant lamination (so-called FCD type I) is largely unresolved. Lipoproteins and particularly low-density lipoprotein receptor-related protein 12 ( @entity8 ) are involved in brain development. Here, we have examined a potential role of @entity8 in the pathogenesis of @entity6 . In vitro knockdown of @entity8 in primary neurons results in @entity4 . In vivo ablation of @entity8 by intraventricularly in utero electroporated shRNAs elicits cortical maldevelopment, i.e. aberrant lamination by malpositioning of upper cortical layer neurons. Subsequent @entity2 phenotyping revealed @entity5 ( @entity7 )-induced @entity3 to be aggravated in cortical @entity8 -silenced @entity0 . Our data demonstrates IUE mediated cortical gene silencing as an excellent approach to study the role of distinct molecules for @entity2 associated focal @entity1 and suggests @entity8 and lipoprotein homeostasis as potential molecular target structures for the emergence of @entity2 -associated @entity6 .

title: XXXX silencing during brain development results in cortical dyslamination and @entity3 sensitization.

answer: @entity8


abstract: Like most vertebrates, birds have two forms of @entity1 (GnRH). @entity2 @entity3 ( @entity3 ) is released at the median eminence to elicit gonadotropin release; @entity2 @entity4 (cGnRH-II) is thought to be non-hypophysiotropic and its function is unclear. Both forms are hypothesized to act as neurotransmitters in the control of reproductive behavior. In the present study, we implanted chronic cannulae aimed at the third ventricle in female white-crowned sparrows (Zonotrichia leucophrys gambelii) to test the effects of both forms of @entity1 on copulation solicitation, a female courtship behavior. This behavior can be elicited in captive, @entity0 -primed females by playing a recording of male song. We quantified the behavioral response to recorded song 30, 60, and 90 min after intracerebroventricular infusion of @entity3 , -II, or saline. cGnRH-II, but not @entity3 , increased solicitation behavior compared with saline 30 min after infusion. Under control conditions, responses to the playback diminish from the 30-min to the 90-min time point. Responses after cGnRH-II infusion followed a similar pattern, whereas after @entity3 , there was no significant response decrement. @entity3 appears to maintain the level of solicitation seen at 30 min after infusion. Our results suggest a behavioral role for cGnRH-II that may be independent of @entity3 .

title: Central administration of XXXX gonadotropin-releasing hormone-II enhances courtship behavior in a female sparrow.

answer: @entity2


abstract: UNASSIGNED: Explicit but not implicit facial emotion perception has been shown to be impaired in @entity1 . In this study, we used newly developed technology in social neuroscience to examine implicit emotion processing. It has been shown that when @entity0 look at faces, they automatically infer social traits, and these trait judgments rely heavily on facial features and subtle emotion expressions even with neutral faces. Eighty-one individuals with @entity1 or @entity2 and 62 control subjects completed a computer task with 30 well-characterized neutral faces. They rated each face on 10 trait judgments: attractive, mean, trustworthy, intelligent, dominant, fun, sociable, aggressive, emotionally stable and weird. The degree to which trait ratings were predicted by objectively-measured subtle emotion expressions served as a measure of implicit emotion processing. Explicit emotion recognition was also examined. Trait ratings were significantly predicted by subtle facial emotional expressions in controls and @entity0 . However, impairment in the implicit emotion perception of fear, happiness, anger and surprise was found in @entity0 . Moreover, these deficits were associated with poorer everyday problem-solving skills and were relatively independent of explicit emotion recognition. Implicit emotion processing is impaired in @entity0 with @entity1 or @entity2 . Deficits in implicit and explicit emotion perception independently contribute to the @entity0 ' poor daily life skills. More research is needed to fully understand the role of implicit and explicit processes in the functional deficits of @entity0 , in order to develop targeted and useful remediation interventions.

title: Implicit emotion perception in XXXX .

answer: @entity1


abstract: BACKGROUND: The French @entity2 ( @entity2 ) registry allows the survey of epidemiological trends. Isolated cases of precapillary @entity2 have been reported in @entity0 who have @entity8 treated with the @entity5 kinase inhibitor @entity9 . METHODS AND RESULTS: This study was designed to describe incident cases of @entity9 -associated @entity2 reported in the French @entity2 registry. From the approval of @entity9 (November 2006) to September 30, 2010, 9 incident cases treated by @entity9 at the time of @entity2 diagnosis were identified. At diagnosis, @entity0 had moderate to severe precapillary @entity2 with functional and @entity1 . No other incident @entity2 cases were exposed to other @entity5 kinase inhibitors at the time of @entity2 diagnosis. Clinical, functional, or hemodynamic improvements were observed within 4 months of @entity9 discontinuation in all but 1 @entity0 . Three @entity0 required @entity2 treatment with endothelin receptor antagonist (n=2) or @entity4 channel blocker (n=1). After a median follow-up of 9 months (min-max 3-36), the majority of @entity0 did not demonstrate complete clinical and hemodynamic recovery, and no @entity0 reached a normal value of mean pulmonary artery pressure ( <=20 mm Hg). Two @entity0 (22%) died at follow-up (1 of unexplained @entity7 and 1 of @entity6 in the context of @entity3 , respectively, 8 and 12 months after @entity9 withdrawal). The lowest estimate of incident @entity2 occurring in @entity0 exposed to @entity9 in France was 0.45%. CONCLUSIONS: @entity9 may induce severe precapillary @entity2 fulfilling the criteria of @entity2 , thus suggesting a direct and specific effect of @entity9 on pulmonary vessels. Improvement is usually observed after withdrawal of @entity9 .

title: Pulmonary arterial hypertension in XXXX treated by @entity9 .

answer: @entity0


abstract: OBJECTIVE: Endoscopic sphincterotomy (ES) reduces sphincter function, which may allow reflux of pancreatic juice and intestinal contents into the common bile duct. The reflux, if present, may cause development of @entity5 , as may @entity8 . We prospectively investigated pancreatobiliary and duodenobiliary reflux after ES. METHODS: In 15 @entity0 with @entity7 , ductal bile was sampled for amylase concentration and bacterial culture during endoscopic retrograde cholangiopancreatography, before and at 7 days to 5 yr after ES. To provide comparative data, ductal bile was sampled in 11 @entity0 with gallbladder @entity1 polyps or @entity8 who did not undergo ES. RESULTS: Amylase concentration of ductal bile in @entity0 with @entity7 before ES was not different from that in @entity0 with @entity6 . Its concentration was increased 7 days after ES compared with that before ES, reaching the level of that in @entity0 with @entity8 . Thereafter, amylase concentration gradually decreased, returning to that before ES by 1 yr. After ES, bactobilia occurred in 60-80% of @entity0 , although none developed acute @entity3 . CONCLUSIONS: Although ES causes transient @entity4 is abolished by 1 yr after ES. ES is unlikely to increase the risk for development of biliary tract @entity2 as long as @entity3 or bile duct stones do not recur.

title: Does endoscopic sphincterotomy cause prolonged XXXX ?

answer: @entity4


abstract: Primary @entity1 of female urethra is rare and represents about 0.02% of all @entity1 found in @entity0 and the majority of them are @entity3 . Diagnosis is difficult due to the fact that the disease has usually reached advanced stage. We report our experience with two @entity0 with @entity2 . METHODS: We describe clinical-pathological findings and treatment carried out in two @entity0 with @entity2 . We review the literature focusing on the origin of these @entity1 and available treatment options. RESULTS: After diagnosis, radical surgery was performed in both @entity0 . Despite this, one @entity0 died of local progression. The other @entity0 is still alive and free of recurrence. CONCLUSIONS: @entity2 of the female urethra is a rare @entity1 of difficult diagnosis. Surgery is the only curative treatment. Chemotherapy (CT ) and radiotherapy (RT ) must be used in @entity0 in whom surgery is not possible, although there is no consensus on the best therapeutic approach. Prognosis tends to be poor due to delay in diagnosis.

title: XXXX : report of two cases and bibliographic review.

answer: @entity2


abstract: BACKGROUND: We have investigated the efficacy of preoperative @entity2 combined with radiation therapy (HIRP) in cases of soft tissue @entity3 (STS) that could be consequently treated with limb salvage. MATERIALS AND METHODS: Thirteen @entity0 with STS in an extremity received HIRP at our institution. Local @entity2 for 1 hour was administered eight to ten times. Radiation therapy (40-60 Gy) was administered at 2 Gy per session. The operation was performed at 2 or 3 weeks after HIRP. RESULTS: Limb salvage surgery was achieved in 12 @entity0 . No local recurrence was observed during a mean follow-up of 27 months. 7 @entity0 had shown only a partial response to the HIRP. There was no correlation between the histological response and the observed reduction in @entity1 volume. CONCLUSIONS: The results of this study suggested that HIRP was an effective local treatment for limb salvage in limb-threatening STS.

title: The efficacy of @entity2 combined with radiation therapy for high-grade soft tissue XXXX .

answer: @entity3


abstract: A review of the treatment of @entity4 ( @entity4 ) was undertaken to examine current methods of management and to ascertain the influence of prematurity and associated medical defects on survival. One hundred @entity0 with @entity4 presented at The @entity0 's Orthopedic Hospital and Medical Center, Seattle, between 1967 and 1979. Eighty-two percent had a blind proximal esophageal pouch and @entity5 ( @entity5 ). Ninety-two @entity0 were initially treated by gastrostomy. Fifty-nine @entity0 were born at term and had no major medical problems. They underwent either primary or delayed (up to 1 week) repair of the esophagus. The survival rate was 93% and surgical mortality was 3%. Twenty-two @entity0 born prematurely or having major medical problems underwent a staged repair. Survival in the staged group was 55% with a surgical mortality of 27%. Overall survival for the entire series was 79% (79/100). The use of air rather than contrast material for the radiographic diagnosis of @entity4 was associated with fewer subsequent @entity2 . There was an 18% incidence of minor @entity3 , regardless of technique. The route of approach (transpleural, retropleural) did not influence mortality or morbidity in this series. There were more than three times as many significant strictures among @entity0 who had double-layer anastomoses (18%) as among those who had single-layer repairs (5%). The surgical treatment of @entity0 with @entity4 has reached a level in which associated @entity1 , or prematurity are now the most significant determinants of survival.

title: @entity4 and XXXX . Review of thirteen years' experience.

answer: @entity5


abstract: PURPOSE: To evaluate the effect of @entity3 ( @entity3 ) on intraocular pressure (IOP) and the anterior chamber angle in primary angle closure after @entity2 ( @entity2 ). SETTING: Tertiary eyecare center at a university hospital, New Delhi, India. DESIGN: Prospective case series. METHODS: The study included eyes with primary angle closure and an IOP over 25.0 mm Hg more than 8 weeks after @entity2 . All eyes had @entity3 by phacoemulsification. Absolute success was defined as an IOP less than 18.0 mm Hg without medications at 12 months. RESULTS: In 44 eyes (24 @entity0 , 20 @entity0 ; mean age 57.2 years    4.2 [SD]), the mean preoperative IOP of 27.1    1.55 mm Hg decreased to 13.2    1.12 mm Hg at 12 months (P < .0001). The angle opening distance at 500  m increased from baseline values at 0 degrees (from 0.104    0.015 mm to 0.31    0.013 mm) and 180 degrees (from 0.202    0.008 mm to 0.412    0.012 mm). The trabecular iris angle also increased at 0 degrees (from 9.3    3.2 degrees to 32.7    5.6 degrees) and 180 degrees (from 9.12    3.2 degrees to 31.7    5.6 degrees) (all P < .0001). In multivariate analysis, the preoperative IOP was the strongest determinant of IOP change (R(2) = 0.69, P < .0001). Absolute success was achieved in 38 eyes (86.3%). CONCLUSION: Clear lens extraction led to a significant reduction in IOP, a widening of the anterior chamber angle, and a reduced need for @entity1 medications in eyes with primary angle closure and persistently raised IOP after @entity2 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Clinical outcomes of XXXX in eyes with primary angle closure.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVE: There is a growing body of evidence suggesting that @entity4 may play crucial role in several @entity1 , such as @entity6 , port wine stain, and @entity5 . To improve our understanding of vascular involvement in these @entity3 , there is a need for a non-invasive imaging modality capable of assessing 3D microcirculations within skin tissue beds in vivo. This study aims to demonstrate whether ultra-high sensitive optical microangiography (UHS-OMAG) is feasible to visualize skin microcirculations in 3D and to quantify microvascular vessel density under normal and @entity7 in vivo. STUDY DESIGN/MATERIAL AND METHODS: An UHS-OMAG system operating at 1,310   nm wavelength was used for in vivo imaging of microcirculation in @entity0 skin. The system has a spatial resolution of    10     m       20     m (axial       lateral), running at 280   fps to acquire 3D imaging dataset to represent morphology and capillary level microvascular blood perfusion within the scanned skin tissue volume. The sensitivity of the system to the blood flow is as low as    4     m/second. With this system, we performed the imaging experiments on the skin of a volunteer with stable plaque-type @entity6 . The microcirculation and structural information of normal and diseased skins were compared both qualitatively and quantitatively. RESULTS: The UHS-OMAG is capable of differentiating the microcirculation within the normal skins from that in the psoriatic skins. The 3D optical images show that the blood vessel elongation and the dense network in the @entity2 skin, the appearance of which is not observed within the normal skin. Based on the results obtained from one subject, the statistical analyses show that higher blood vessel density presented within the @entity2 skin than that of the normal skin. CONCLUSIONS: UHS-OMAG can be a valuable tool for imaging skin microcirculations non-invasively with high-speed and high-sensitivity, and therefore may have a useful role in future clinical diagnosis and treatment of @entity1 such as @entity6 in @entity0 subjects.

title: In vivo volumetric imaging of microcirculation within @entity0 skin under XXXX using optical microangiography.

answer: @entity7


abstract: @entity2 ( @entity4 ) is characterized by loss of melanin-positive dopaminergic neurons in the substantia nigra. @entity3 (MM), a melanocyte-derived @entity1 , occurs with higher than expected frequency among @entity4 @entity0 . Red-haired individuals exhibit a threefold risk for developing MM than dark-haired @entity0 ; @entity4 risk also increases with lighter hair color. One plausible explanation for the associations between MM, hair color, and @entity4 is the @entity5 ( @entity5 ) gene that plays a key role in hair and skin pigmentation as well as in MM predisposition. We hypothesized that specific @entity5 variants may predispose to both MM and @entity4 . Genotyping of the @entity5 gene was performed for 16 @entity4 @entity0 with MM ( @entity4 + MM+) and for three sets of age, sex, and ethnically matched controls, including 36 @entity0 with @entity4 ( @entity4 + MM-), 37 with MM ( @entity4 - MM+) and 37 with neither diagnosis ( @entity4 - MM-). No association was found between @entity5 variants and the co-occurrence of @entity4 and MM. The risk for MM was higher in carriers of two @entity5 variants versus with no @entity5 variant (odds ratio (OR)   =   5.0, 95  % confidence interval (CI) 1.7-14.4, p   =   0.003). The risk for @entity4 in carriers of two @entity5 variants was markedly lower (OR   =   0.213, 95  % CI 0.063-0.725) compared with individuals with no @entity5 variant (p   =   0.013). In this study, @entity5 variants were not associated with both MM and @entity4 . Further studies in larger cohorts are necessary to confirm these preliminary results.

title: The @entity5 ( @entity5 ) Variants Do Not Account for the Co-occurrence of @entity2 and XXXX .

answer: @entity3


abstract: In @entity0 photolyase, excitation of the FAD cofactor in its semireduced radical state (FADH*) induces an electron transfer over approximately 15 A from @entity3 W306 to the @entity2 . It has been suggested that two additional tryptophans are involved in an electron transfer chain FADH* <-- W382 <-- W359 <-- W306. To test this hypothesis, we have mutated W382 into redox inert @entity1 . Ultrafast transient absorption studies showed that, in @entity4 photolyase, excited FADH* decayed with a time constant tau approximately 26 ps to fully reduced @entity2 and a @entity3 cation radical. In @entity5 mutant photolyase, the excited @entity2 was much longer lived (tau approximately 80 ps), and no significant amount of product was detected. We conclude that, in @entity4 photolyase, excited FADH* is quenched by electron transfer from W382. On a millisecond scale, a product state with extremely low yield ( approximately 0.5% of @entity4 ) was detected in @entity5 mutant photolyase. Its spectral and kinetic features were similar to the fully reduced @entity2 /neutral @entity3 radical state in @entity4 photolyase. We suggest that, in @entity5 mutant photolyase, excited FADH* is reduced by W359 at a rate that competes only poorly with the intrinsic decay of excited FADH* (tau approximately 80 ps), explaining the low product yield. Subsequently, the W359 cation radical is reduced by W306. The rate constants of electron transfer from W382 to excited FADH* in @entity4 and from W359 to excited FADH* in @entity5 mutant photolyase were estimated and related to the donor-acceptor distances.

title: Dissection of the triple XXXX electron transfer chain in @entity0 DNA photolyase: Trp382 is the primary donor in photoactivation.

answer: @entity3


abstract: UNASSIGNED: @entity0 with brain @entity1 from @entity3 have poor outcomes. Radiation is used both for prognostic and symptomatic value. We aimed to further clarify the role of stereotactic radiosurgery (SRS) and whole brain radiotherapy (WBRT) as well as the prognostic implication of various sites of @entity2 . The records of 73 consecutive @entity0 treated at the University of Rochester Medical Center for brain-metastatic @entity3 from January 2004 to October 2013 were reviewed. The median @entity4 ( @entity4 ) was 3.0  months. @entity0 treated with WBRT alone had decreased @entity4 compared to those treated with SRS alone (HR  =  0.38, p  =  0.001) or WBRT and SRS (HR  =  0.51, p  =  0.039). The mean number of brain @entity1 differed (p  =  0.002) in @entity0 in @entity0 who received WBRT (4.0) compared to those who did not (2.0). Among @entity0 with @entity2 (n  =  63), bone @entity1 (HR  =  1.86, p  =  0.047, n  =  15) was a negative prognostic factor; liver (HR  =  1.59, p  =  0.113, n  =  17), lung (HR  =  1.51, p  =  0.23, n  =  51) and adrenal @entity1 (HR  =  1.70, p  =  0.15, n  =  10) were not. In @entity0 with concurrent brain and lung @entity1 , those with disease limited to those two sites ( @entity4  =  8.7 mo, n  =  13) had improved @entity4 (HR  =  0.44, p  =  0.014) compared to those with additional disease ( @entity4  =  1.8 mo, n  =  50). Based on this hypothesis-generating retrospective analysis, SRS may offer survival benefit compared to WBRT alone in @entity0 with brain metastatic @entity3 . Bone @entity1 appears to confer a particularly poor prognosis. Those with disease confined to the lung and brain may represent a population with improved prognosis.

title: Brain @entity1 from XXXX : the prognostic value of varying sites of @entity2 .

answer: @entity3


abstract: BACKGROUND: Use of antimicrobial agents is one of the important strategies to prevent @entity0 . These agents vary in their abilities to deliver preventive and therapeutic benefits. OBJECTIVES: This invitro study was conducted to assess antimicrobial efficacy of different toothpastes against various oral pathogens. MATERIALS AND METHODS: A total of nine toothpastes in three groups were tested for their antimicrobial activity against @entity1 (ATCC 25922), @entity2 (ATCC 25923), @entity5 (ATCC 0266P) and @entity4 (Laboratory Strain) by modified agar well diffusion method. Statistical Analysis was performed using Minitab Software. A p-value of less than 0.05 was considered significant. RESULTS: @entity6 -based dental formulation with combination of @entity3 (1000ppm) exhibited higher antimicrobial activity against test organisms than the combination of lower @entity3 -concentration or @entity7 . Among herbal dentifrices, formulation containing Neem, Pudina, Long, Babool, Turmeric and Vajradanti showed significant antimicrobial activity against all the four tested microorganisms (p<0.05). However, against @entity5 , all three herbal products showed significant antimicrobial activity. Homeo products showed least antimicrobial activity on the tested strains. Formulation with kreosotum, Plantago major and calendula was significantly effective only against @entity5 . CONCLUSION: In the present study, antimicrobial activity of the toothpaste containing both @entity6 and @entity3 (1000ppm) as active ingredients showed a significant difference (p< 0.05) against all four tested microflora compared to that of with lower @entity3 -concentration or @entity7 . Of herbal groups, the only dentifrice containing several phytochemicals was found to be significantly effective and comparable to @entity6 - @entity3 (1000ppm) formulation. Thus, this herbal toothpaste can be used as alternative to @entity6 -based formulations. However, these results might not be clinically useful unless tested invivo.

title: Comparison of Antimicrobial Efficacy of XXXX - Containing, Herbal and Homeopathy Toothpastes- An Invitro Study.

answer: @entity6


abstract: BACKGROUND/AIMS: In @entity7 , reactive @entity0 species (ROS) are involved in cell @entity3 and @entity2 , but the mechanisms are not completely elucidated. To elucidate the mechanisms of hepatocyte cell @entity3 induced by the ROS @entity4 anions and @entity5 , primary cultures of hepatocytes were exposed to the @entity4 anion donor @entity14 (10-50 micromol/L) or @entity6 (1-5 mmol/L). Hepatocytes were also treated with caspases and MAPKs inhibitors, @entity4 dismutase ( @entity9 -SOD) and SNAP, a @entity8 donor. Apoptosis was determined by measuring @entity13 , -6, -3 activation and cleaved @entity15 , and @entity1 cell @entity3 by Sytox Green staining. RESULTS: (1) @entity14 (50 micromol/L) induces @entity12 phosphorylation, @entity13 , -6, -3 activation, @entity15 cleavage and apoptosis. @entity4 anions-induced apoptosis is dependent on @entity12 activity. @entity14 (50 micromol/L) induces the phosphorylation of @entity10 and this attenuates cell @entity3 . (2) @entity6 increases @entity1 cell @entity3 at high concentration or when @entity6 detoxification is impaired. @entity6 does not activate MAPKs signalling. (3) @entity9 -SOD prevents @entity10 -, @entity12 - phosphorylation, caspase activation and apoptosis induced by @entity14 . @entity11 depletion increases @entity14 -induced apoptosis. (4) SNAP abolishes @entity14 -induced apoptosis but increases @entity1 cell @entity3 . CONCLUSIONS: In normal hepatocytes, @entity4 anions-induced caspase activation and apoptosis is dependent on @entity12 activity and totally abolished by @entity4 scavengers.

title: @entity4 anions and @entity5 induce hepatocyte XXXX by different mechanisms: involvement of @entity12 and ERK MAP kinases.

answer: @entity3


abstract: Glycyrrhiza glabra L. is used in folk medicine for treatment of @entity5 including @entity11 . The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute @entity2 profile in @entity0 . Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. @entity9 and @entity8 at doses of 30 and 100 mg/kg were used as positive controls, respectively. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach. Oral administration of the extract at 1600 mg/kg did not produce toxic symptoms and mortality in @entity0 . 2950 mg/kg was determined as the oral LD50. The HEGG (50-200 mg/kg) showed a significant reduction in @entity3 index in @entity10 / @entity4 -induced @entity3 . G. glabra extract (50-150 mg/kg) showed antiulcer activity against @entity7 -induced @entity5 dose dependently. The extract effectively inhibited formation of @entity5 induced by @entity4 . The extract (200 mg/kg) was more potent than @entity9 (30 mg/kg). HEGG reduced the @entity3 index in hypothermic stress induced @entity6 in @entity0 and the antiulcer effect was comparable to that of @entity8 . The results indicated that G. glabra hydroalcoholic extract exerted an antiulcergenic effect that could be associated with increase in gastric @entity1 factors.

title: Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of @entity6 in XXXX .

answer: @entity0


abstract: UNASSIGNED: The present study analyzed the changes in gene expression induced by the Cryotop vitrification technique in @entity0 blastocyst-stage embryos, using Agilent EmbryoGENE microarray slides. @entity0 in  vitro-produced embryos were vitrified and compared with nonvitrified (control) embryos. After vitrification, embryos were warmed and cultured for an additional 4  hours. Survived embryos were used for microarray analysis and quantitative polymerase chain reaction (qPCR) quantification. Survival rates were higher (P  <  0.05) in the control embryos (100%) than in the vitrified embryos (87%). Global gene expression analysis revealed that only 43 out of 21,139 genes exhibited significantly altered expression in the vitrified embryos compared to the control embryos, with a very limited fold change (P  <  0.05). A total of 10 genes were assessed by qPCR. Only the @entity1 ( @entity1 ) gene presented differential expression (P  <  0.05) according to both the array and qPCR methods, and it was overexpressed in vitrified embryos. Although, the major consequence of vitrification seems to be the activation of the apoptosis pathway in some cells. Indeed, @entity1 is part of the activating protein 1 transcription factor complex and is implicated in a variety of cellular processes, including proliferation, differentiation, and apoptosis. Therefore, our results suggest that a limited increase in the rate of apoptosis was the only detectable response of the embryos to vitrification stress.

title: Effect of vitrification using the Cryotop method on the gene expression profile of in  vitro-produced XXXX embryos.

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) is a common, underdiagnosed @entity2 . OBJECTIVES: The main objectives of this study were to determine the occurrence of @entity3 relative to age and gender, to analyze its cutaneous distribution, and to investigate any possible familial basis for this condition, its impact on @entity0 , and the types and efficacy of previous treatments. METHODS: All @entity0 presenting to the outpatient dermatology clinic at the study institution and their relatives were examined for the presence of @entity3 and were questioned about family history and previous treatment. Photographs and biopsies of suspected cases of @entity3 were obtained. RESULTS: Of 2400 @entity0 seen between August and December 2013, 286 @entity0 were diagnosed with @entity3 (135 males, 151 females; prevalence: 11.9%). @entity0 presented more frequently than @entity0 with complaints of @entity3 (6.3 vs. 4.2%), and more @entity0 had received prior treatment for @entity3 (10.5 vs. 2.8%). The most commonly affected sites were the face (100%), interscapular area (10.5%), and arms (3.1%). Lesions involved the nasal alae in 96.2%, the nasal tip in 90.9%, the chin in 55.9%, and the cheeks in 52.4% of @entity0 . Only 15.7% of @entity0 had @entity1 , and only 4.5% had @entity1 . Among the 38 previously treated @entity0 , 65.8% reported temporary improvement. CONCLUSIONS: @entity3 is a common condition that predominantly affects the face in @entity0 of all ages. Additional studies employing larger cohorts from multiple centers will be required to determine the prevalence of @entity3 in the general population.

title: Incidence of XXXX at a single institution in Yemen.

answer: @entity3


abstract: BACKGROUND: Compression ultrasonography is the mainstay of diagnosis of @entity1 ( @entity1 ) of the legs. Compression ultrasonography can be extended to the entire deep venous system (whole-leg) or restricted to the proximal veins only (limited), and the two approaches are clinically equivalent. We aimed to assess the diagnostic value of an algorithm combining whole-leg and limited compression ultrasonography. METHODS: We did a prospective, multicentre, cohort study at eight centres in five countries. Consecutive outpatients aged 18 years or older with suspected @entity1 underwent D-dimer measurement and pretest clinical probability assessment. @entity1 was ruled out without further testing if pretest probability was unlikely and D-dimer was negative (group 1). @entity0 in whom either pretest probability was likely or who were positive for D-dimer underwent limited compression ultrasonography only (group 2). Finally, @entity0 in whom pretest probability was likely and who had a positive measurement for D-dimer underwent extended whole-leg compression ultrasonography (group 3). All @entity0 in whom @entity1 was ruled out were followed up for 3 months. The primary outcome was the incidence of objectively recorded @entity2 . The primary analysis included all @entity0 managed according to the study protocol. This study is registered with ClinicalTrials.gov, number NCT01412242. The final results are reported here. FINDINGS: Between March 1, 2011, and July 31, 2014, 1348 consecutive outpatients were referred for this study, of whom 1162 were eligible to participate. After pretest probability assessment and D-dimer testing, 351 were in group 1, 401 in group 2, and 410 in group 3. Limited compression ultrasonography was positive in 12 (3%) @entity0 in group 2 and extended whole-leg compression ultrasonography was positive in 200 (49%) @entity0 in group 3. 82 (39%) of all @entity1 diagnosed at baseline were isolated distal thromboses. 26 protocol violations were reported. Thus, 351 @entity0 from group 1, 371 @entity0 in group 2, and 202 @entity0 in group 3 who had been excluded for @entity1 by the algorithm were included in the primary analysis at 3 months. One, four, and three DVTs were reported, respectively. Thus, the 3-month incidence of @entity2 in untreated @entity0 after a negative diagnostic strategy was 0  87% (95% CI 0  44-1  70). INTERPRETATION: An algorithm combining limited and whole-leg compression ultrasonography could be a reliable, safe, and convenient method for diagnostic management of outpatients with clinically suspected @entity1 . FUNDING: None.

title: Analysis of an algorithm incorporating limited and whole-leg assessment of the deep venous system in symptomatic outpatients with suspected XXXX (PALLADIO): a prospective, multicentre, cohort study.

answer: @entity1


abstract: Slotted stainless Palmaz stents (PS) remain the most commonly used in @entity2 ( @entity2 ). Limitations of PS include @entity4 , foreshortening, poor conformability on expansion, @entity3 , and jailing of side branches. Recently, stents with open-cell design (IntraStent; IS) in appropriate sizes for @entity2 have been introduced. We reviewed our experience with the IS, comparing performance with the PS in a retrospective nonrandomized, uncontrolled observational study. Between May 1999 and March 2001, 34 IS (10-36 mm) and 34 PS (10-40 mm) were implanted in 57 @entity0 (3 months to 25 years old; median, 3.24 years) in @entity1 . There was no statistically significant difference between the two groups in efficacy, % diameter increase (162% +/- 203% for IS vs. 153% +/- 177% for PS), and % gradient reduction (69% +/- 23% for IS vs. 80% +/- 27% for PS). Other aspects of stent performance differed significantly (P < 0.05): PS forshortened more (mean 18% for PS vs. 0% for IS) and were associated with @entity3 (9/34 for PS vs. 0/34 for IS; P = 0.002), but had no evidence of intimal protrusion in between struts (0/34 for PS vs. 14/34 for IS; P < 0.001) and no recoil > 15% (0/34 for PS vs. 7/34 for IS; P = 0.006); IS conformed almost twice as well to vessel curvature (P = 0.003). Although these factors did not affect immediate procedural success, @entity3 in two PS resulted in stent malpositions. Among IS, the origins of three covered side branches were accessed and balloon dilated up to 6 mm through the side of the stent. In conclusion, stents with open-cell design have some characteristics that seem beneficial for their use in @entity2 : they foreshorten less, are conformable, are less likely to cause @entity3 , and can allow access to jailed branches. However, they have a higher incidence of significant percent recoil and protrusion of intimal tissue in between struts, which may impact long-term stent performance.

title: Open-cell design stents in XXXX : a comparison of IntraStent vs. Palmaz stents.

answer: @entity2


abstract: Transcriptional regulation appears to be fundamental to circadian oscillations of clock gene expression. These oscillations are believed to control output rhythms. The transcriptional feedback loop and a model of interlocked loops have been proposed as the basis for these oscillations. We characterized the genomic structure of the @entity1 @entity4 gene ( @entity4 ) and defined the @entity4 promoter region. Transcription of @entity4 was activated by @entity6 , @entity5 , and @entity2 , and was repressed by @entity3 -CLOCK dimers. Therefore, CRY, @entity2 , and @entity3 -CLOCK play bidirectional roles in transcription when they are at high levels by late day and midnight, respectively. This underlies the opposite phase of @entity3 compared to CRY and PER. We propose that a @entity3 negative feedback loop interlocks with the CRY and @entity2 negative feedback loop by inter-activation, forming a third positive forward loop. This transcriptional model suggests a molecular basis for the maintenance of stability, persistence, and period of circadian rhythms. The transcriptional potency of CRY is predominant within the @entity0 clock, suggesting a clearance mechanism for CRY in period maintenance. (c)2002 Elsevier Science (USA).

title: Interactivating feedback loops within the @entity0 clock: @entity3 is negatively autoregulated and upregulated by @entity6 , XXXX , and @entity2 .

answer: @entity5


abstract: The hypothalamic melanocortin system is unique among neuropeptide systems controlling energy homeostasis, in that both anorexigenic proopiomelanocortin ( @entity6 )-derived and orexigenic @entity9 ( @entity9 )-derived ligands act at the same receptors, namely melanocortin 3 and 4 receptors (MC3/4R). @entity9 clearly acts as a competitive antagonist at @entity10 and @entity8 but may also have an inverse agonist action at these receptors. The physiological relevance of this remains uncertain. We generated a @entity0 lacking both @entity6 and @entity9 [double knockout (DKO) @entity0 ]. Phenotyping was performed in the absence and presence of glucocorticoids, and the response to central peptide administration was studied. The phenotype of DKO @entity0 is indistinguishable from that of @entity0 lacking @entity6 alone, with both exhibiting highly similar degrees of @entity5 and @entity1 , fat, and lean mass compared with wild-type controls. After a 24-h fast, there was no difference in the refeeding response between @entity6 (-/-) and DKO @entity0 . Similarly, @entity3 supplementation caused an equivalent increase in food intake and body weight in both genotypes. Although the central administration of [ @entity11   , @entity7   ]-a-MSH to DKO @entity0 caused a @entity2 and an increase in brown adipose tissue @entity4 expression, both of which could be antagonized with the coadministration of @entity9 , there was no effect of @entity9 alone. These data suggest @entity9 acts predominantly as a melanocortin antagonist. If @entity9 has significant melanocortin-independent actions, these are of insufficient magnitude in vivo to impact any of the detailed phenotypes we have measured under a wide variety of conditions.

title: Loss of agouti-related peptide does not significantly impact the phenotype of @entity0 XXXX deficiency.

answer: @entity6


abstract: Echocardiography is an established method for the diagnosis of @entity3 . Echographic findings in @entity1 have also been described. The interpretation of a changing serial echogram during the clinical course of @entity1 has not been established. Sixteen @entity0 with echographic evidence of @entity3 were followed with serial echographic studies. In seven, surgical or autopsy correlation was obtained. Because of the serial changes noted we undertook a study in @entity2 to clarify the problem of variability in intensity of sound reflected from the pericardial space. Three open-chested @entity2 were studied with rapid sequence surface echograms as blood introduced into the pericardial space was converted from the unclotted to the clotted state. In all three @entity2 blood clooting increased the intensity or sound reflected from the pericardial space. Our study of two @entity0 with fibroadhesive @entity1 documents serial changes in echoes from the pericardium and pericardial space accompanying the clinical evolution of the disease process, and suggests a method for avoiding the commonly encountered difficulty in proper identification of the pericardial and epicardial echoes. Our preliminary studies suggest that serial echograms should play an important role in the management of @entity0 with @entity3 ; further surgical/pathological correlations are required.

title: The role of serial echocardiography in the evaluation and differential diagnosis of XXXX .

answer: @entity1


abstract: Cytokines direct the differentiation of naive @entity1 (+) T cells into either @entity0 -producing T(h)1 cells or @entity3 -producing T(h)2 cells. In this study, we analyzed the activation of @entity8 , @entity5 and @entity11 (together with @entity9 and @entity10 ), and the expression of the recently identified @entity12 ( @entity12 ) proteins, in differentiated T(h)1 and T(h)2 cells, both before and after re-stimulation with anti-CD3 and anti- @entity2 . In addition to the polarized activation of @entity9 in T(h)1 cells and @entity10 in T(h)2 cells, we found that @entity5 and @entity11 are selectively activated in T(h)1 cells after differentiation. This activation of @entity5 and @entity11 was maintained after TCR re-stimulation. The selective activation of @entity5 and @entity11 in T(h)1 cells was associated with differential induction of @entity12 molecules. After re-stimulation, @entity6 expression was significantly increased in T(h)2 cells, but not in T(h)1 and non-polarized 'T(h)' cells. Additionally, the level of CIS was higher in T(h)2 cells compared with T(h)1 and T(h) cells. In contrast, the expression of @entity7 was higher in T(h)1 cells. The differential induction of @entity12 proteins was paralleled by the differential expression of cytokines in re-stimulated T(h)1 and T(h)2 cells ( @entity0 and @entity3 / @entity4 respectively). Our results suggests that @entity5 and @entity11 , possibly regulated by the @entity12 proteins, may play a role in the differentiation of T(h) cells, and in the maintenance of the T(h)1 and T(h)2 phenotype.

title: Differential activation of @entity5 and XXXX and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells.

answer: @entity11


abstract: PURPOSE: To summarize the characteristics of @entity5 ( @entity5 ) and to evaluate the therapeutic effect of drug therapy combined with transarterial embolization. @entity0 AND METHODS: From 2007 to 2011, 6 cases of @entity5 that underwent drug therapy and transarterial embolization were retrospectively analyzed, comprising of 3 male and 3 female @entity0 ; the ages of the @entity0 ranged from 3 to 40 days. The lesions were located in the temporal region (1 of 6, 16.7%), parotid region (2 of 6, 33.3%), or submandibular region and neck (3 of 6, 50%). All the @entity0 were followed for 12 to 18 months. Therapeutic outcomes were assessed by evaluating the platelet count, coagulation parameters, and size of the lesion. RESULTS: Positive responses were visible shrinkage of the @entity3 or lightening of the skin color of the @entity1 (or both) within 8 to 72 hours in 4 @entity0 (66.67%). These occurred within 1 week in 5 @entity0 (83.33%) and within 2 weeks in all @entity0 (100%). The mean platelet count before treatment was 18,000/L (range, 8,000 to 33,000/L). After the first week of medical treatment, the mean platelet count increased to above 80,000/L in 5 @entity0 (83.33%); it began to increase on the second day after embolization and reached 102,000/L in 1 @entity0 (16.67%). All 6 cases (100%) showed good results with treatment. A 12- to 18-month follow-up evaluation was obtained for all treated @entity0 , and no rebound growth or platelet count decreases were observed. No severe or obvious adverse complications were noted during all treatment courses. CONCLUSIONS: For most @entity3 presenting with @entity5 , good results can be obtained with systemic medical treatment. Transcatheter @entity2 with @entity4 particles combined with systemic medical treatment should be considered an efficacious and important therapeutic option for challenging cases.

title: Comprehensive therapy for XXXX presenting with @entity5 in the maxillofacial region.

answer: @entity3


abstract: @entity1 ( @entity1 ) is a major health concern, and early @entity1 diagnosis is a primary radiological concern. The goal of imaging @entity2 is the early identification of high-grade @entity4 nodules/early @entity1 since their treatment is associated with a higher chance of radical cure and lower recurrence rates. The newly introduced MRI contrast agent @entity5 ( @entity5 , @entity5 ) has enabled the concurrent assessment of @entity0 vascularity and hepatocyte-specific contrast enhancement during the @entity3 ( @entity3 ), which can help to detect and characterize smaller HCCs and their precursors. @entity3 -EOB-MRI identifies hypovascular @entity1 nodules that are difficult to detect using ultrasonography or computed tomography, which do not show the diagnostic @entity1 hallmarks of arterial washin and portal/delayed washout. During the @entity3 , typical @entity1 and early @entity1 appear hypointense on EOB-MRI, whereas low-grade @entity4 or regenerative nodules appear as iso- or hyperintense lesions. The diagnostic accuracy of EOB-MRI for the diagnosis of early @entity1 is approximately 95-100%. One third of hypovascular hypointense nodules in @entity3 become hypervascular 'progressed' @entity1 , with a 1- and 3-year cumulative incidence of 25 and 41%, respectively. Therefore, these hypovascular nodules should be strictly followed up or definitely treated as typical @entity1 . Due to this capability of identifying the precursors and biological behavior of @entity1 , EOB-MRI has rapidly become a key imaging tool for the diagnosis of @entity1 and its precursors, despite the scarce MRI availability throughout Europe. With increasing experience, EOB-MRI may eventually be established as the diagnostic imaging modality of choice in this setting. Full recognition by the Western EASL-AASLD guidelines is expected.

title: Focal lesions in the cirrhotic liver: their pivotal role in XXXX -enhanced MRI and recognition by the Western guidelines.

answer: @entity5


abstract: INTRODUCTION: @entity2 is among the most common and treatable @entity1 . Adrenergic and cannabinoid systems have an important role in the neurobiology of @entity2 . The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid @entity5 receptor antagonist ( @entity6 ) in the presence of alpha-1 adrenergic antagonist ( @entity3 ) on @entity0 behavior in the EPM. METHODS: In this study, the data were obtained from male @entity0 @entity0 , which weighing 200- 250 g. Animal behavior in EPM were videotaped and saved in computer for 10 min after IP injection of saline, @entity6 (0.3 mg/kg), @entity3 (0.3 mg/kg) and @entity6 + @entity3 , subsequently scored for conventional indices of @entity2 . During the test period, the number of open and closed arms entries, the percentage of entries into the open arms of the EPM, and the spent time in open and closed arms were recorded. @entity4 was considered as a positive control drug with anxiolytic effect (0.3, 0.6, 1.2 mg/kg). RESULTS: @entity4 increased the number of open arm entries and the percentage of spent time on the open arms. IP injection of @entity6 before EPM trial decreased open arms exploration and open arm entry. Whereas, @entity3 increased open arms exploration and open arm entry. This study showed that both substances in simultaneous injection have conflicting effects on the responses of each of these two compounds in a single injection. DISCUSSION: Injection of @entity5 receptor antagonist may have an anxiogenic profile in @entity0 , whereas adrenergic antagonist has an anxiolytic effect. Further investigations are essential for better understanding of anxiolytic and anxiogenic properties and neurobiological mechanisms of action and probable interactions of the two systems.

title: Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on XXXX in Male @entity0 .

answer: @entity2


abstract: UNASSIGNED: @entity8 ( @entity8 ) is a deubiquitinating enzyme with key roles in the regulation of @entity4 and @entity5 signaling, suggesting its importance in tumorigenesis. However, the mechanisms and regulatory roles of @entity8 in @entity1 , including @entity2 , remain largely elusive. Here, we present the first evidence that @entity8 regulates the growth, invasion, and @entity0 of @entity2 . @entity8 expression was significantly elevated in @entity2 tissues and was significantly associated with @entity1 size, differentiation, distant @entity0 , and poor survival. Knockdown of @entity8 diminished @entity2 cell growth, colony formation, migration, and invasion in vitro and @entity0 in vivo. Importantly, we found that @entity7 ( @entity7 ) is indispensable for @entity8 -mediated oncogenic activity in @entity2 . Mechanistically, we observed that @entity8 interacted with and stabilized @entity7 via deubiquitination. This resulted in activation of @entity3 and reduction of @entity6 , critical regulators of @entity1 cell growth and @entity0 . Examination of clinical samples confirmed that @entity8 expression positively correlates with @entity7 protein expression, but not mRNA transcript levels. Taken together, our results demonstrate that aberrant expression of @entity8 contributes to the development and progression of @entity2 and reveal a critical mechanism underlying @entity8 -mediated oncogenic activity. These observations suggest that the potential of harnessing proteolytic degradation processes for therapeutic manipulation may offer a much-needed new approach for improving @entity2 treatment strategies. @entity1 Res; 76(1); 1-13.   2015 AACR.

title: Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of XXXX Is Required for Potentiating Colorectal Oncogenesis.

answer: @entity7


abstract: @entity1 and @entity3 ( @entity3 ) are two emergent @entity2 transmitted by the widely distributed European tick Ixodes ricinus. The life cycle of the vector and the number of hosts involved requires the development of complex models which consider different routes of pathogen transmission including those occurring between ticks that co-feed on the same host. Hence, we consider here a general model for @entity2 . We assumed ticks feed on two types of host species, one competent for viraemic transmission of @entity0 , the second incompetent but included a third transmission route through non-viraemic transmission between ticks co-feeding on the same host. Since a blood meal lasts for several days these routes could lead to interesting nonlinearities in transmission rates, which may have important effects.We derive an explicit formula for the threshold for disease persistence in the case of viraemic transmission, also for the case of viraemic and non-viraemic transmission. From this formula, the effect of parameters on the persistence of @entity0 can be determined. When only viraemic transmission occurs, we confirm that, while the density of the competent host has always a positive effect on @entity0 persistence, the density of the incompetent host may have either a positive effect, by amplifying tick population, or a negative ("dilution") effect, by wasting tick bites on an incompetent host. With non-viraemic transmission, the "dilution" effect becomes less relevant. On the other hand, if the nonlinearity due to extended feeding is included, the dilution effect always occurs, but often at unrealistically high host densities. Finally, we incorporated the effects of tick aggregation on the hosts and correlation of tick stages and found that both had an important effect on @entity0 persistence, if non-viraemic transmission occurred.

title: Thresholds for disease persistence in models for XXXX including non-viraemic transmission, extended feeding and tick aggregation.

answer: @entity2


abstract: UNASSIGNED: Invasive @entity0 is the most common type of @entity3 in @entity1 worldwide. However, the mechanism responsible for @entity0 @entity2 is still unclear and needs further illustration. It has been proven that @entity7 ( @entity7 ) promotes @entity2 of the @entity3 cells. However, the interaction between @entity10 and @entity7 has not been studied. Therefore, in the present research, the effect of @entity7 on the malignant progression of invasive @entity0 promoted by membrane @entity6 receptora ( @entity10 ) was investigated. The results showed that the protein expression of @entity10 , p- @entity5 and @entity7 increased in the cancerous tissues compared to that of the noncancerous breast tissue. Furthermore, a positive correlation was found between @entity10 and @entity8 , as well as the number of involved local lymph nodes. On the other hand, a negative correlation was observed between @entity10 and @entity4 receptors (ER) along with @entity6 receptors (PR). Similarly, a positive association was found between @entity7 and the number of involved local lymph nodes. Besides, the high expression of @entity7 also had a positive correlation with the @entity3 size. However, the high level of @entity7 had a negative correlation with ER and PR. In addition, there was a positive correlation between @entity10 and p- @entity5 together with @entity7 . The results confirm that @entity10 was a major marker of harmful prognosis and it promoted the expression of @entity7 during invasion to the local lymph nodes through the pathway of @entity9 / @entity5 . The present study provided a novel therapeutic strategy to inhibit @entity0 growth by preventing @entity10 signaling pathway.

title: @entity0 and XXXX by @entity10 Through the @entity9 / @entity5 Signaling Pathway.

answer: @entity2


abstract: UNASSIGNED: The effects of the solvent and protonation state on the electronic absorption spectrum of the @entity4 ( @entity2 ), a model of the photoactive yellow protein (PYP), have been studied using the ASEP/ @entity0 (averaged solvent electrostatic potential from molecular dynamics) method. Even though, in the protein, the chromophore is assumed to be in its @entity5 monoanionic form, when it is found in water solution pH control can favor neutral, monoanionic, and dianionic species. As the @entity2 has two hydrogens susceptible of deprotonation, both @entity1 and @entity5 monoanions are possible. Their relative stabilities are strongly dependent on the medium. In gas phase, the most stable isomer is the @entity5 while in aqueous solution it is the @entity1 , although the population of the @entity5 form is not negligible. The s-cis, s-trans, @entity3 , and anti conformers have also been included in the study. Electronic excited states of the chromophore have been characterized by SA-CAS(14,12)-PT2/cc-pVDZ level of theory. The bright state corresponds, in all the cases, to a     >    * transition involving a charge displacement in the system. The magnitude and direction of this displacement depends on the protonation state and on the environment (gas phase or solution). In the same way, the calculated solvatochromic shift of the absorption maximum depends on the studied form, being a red shift for the neutral, @entity1 monoanion, and dianionic chromophores and a blue shift for the @entity5 monoanion. Finally, the contribution that the solvent electronic polarizability has on the solvent shift was analyzed. It represents a very important part of the total solvent shift in the neutral form, but its contribution is completly negligible in the mono- and dianionic forms.

title: Solvent Effects on the Absorption Spectra of the XXXX Chromophore in Its Different Protonation Forms.

answer: @entity4


abstract: UNASSIGNED: Summary OBJECTIVE : The aim of this study was to evaluate 1. the differences among the cleft sides of @entity1 ( @entity1 ) @entity0 , non-cleft sides of the same @entity1 @entity0 and well matched control @entity0 in the root development and position of permanent upper central incisors and 2. possible gender differences. MATERIALS AND METHODS: The study sample consisted of 40 @entity0 (20 males and 20 females; mean age: 14.84  3.2 years) with non-syndromic @entity1 @entity0 , and 40 control @entity0 (20 males and 20 females; mean age: 13.38  1.6 years). Cone-beam computed tomography (CBCT) images were taken off from all @entity0 . All tomographs were obtained in supine position by using CBCT (NewTom 5G, QR, Verona, Italy). RESULTS: Significant smaller root volume of central incisor was observed on the cleft side than on the non-cleft side of @entity1 @entity0 (P < 0.05). No significant difference in the root development and position of the central incisors was found between the non-cleft side of the @entity1 and the control group (P > 0.05). There were no statistically significant gender differences in any linear, angular, or volumetric measurements (P > 0.05). Only the root volume of the cleft side was smaller in females than in males (P < 0.05). CONCLUSIONS: In general, root volumes of central incisors on the cleft side were 12.15 per cent smaller than non-cleft side. Root development of the central incisor was much more influenced by the cleft in females than in males.

title: Effects of XXXX on the development of permanent upper central incisors: a cone-beam computed tomography study.

answer: @entity1


abstract: PURPOSE: To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), @entity7 0.1% or @entity6 0.45%, relative to topical @entity5 alone in @entity4 surgery. MATERIALS AND METHODS: A total 91 subjects scheduled to undergo @entity4 operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free @entity6 0.45%; and Group 3, postoperative @entity5 only, as a control. Outcome measures included intraoperative change in pupil size, postoperative @entity2 control, change in macular thickness and volume, and ocular surface status after operation. RESULTS: Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p<0.05). There was significantly less ocular inflammation 1 week and 1 month postoperatively in both NSAID groups than the control group. The changes in central foveal subfield thickness measured before the operation and at postoperative 1 month were 4.30  4.25, 4.87  6.03, and 12.47  12.24  m in groups 1 to 3, respectively. In the control group, macular thickness and volume increased more in @entity0 with @entity1 ( @entity1 ), compared to those without @entity1 . In contrast, in both NSAID groups, NSAIDs significantly reduced macular changes in subgroups of @entity0 with or without @entity1 . Although three ocular surface parameters were worse in group 1 than in group 2, these differences were not significant. CONCLUSION: Adding preoperative and postoperative bromfenac 0.1% or @entity6 0.45% to topical @entity5 can reduce intraoperative miosis, @entity3 , and macular changes more effectively than postoperative @entity5 alone.

title: The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and XXXX 0.45%, on @entity4 Surgery.

answer: @entity6


abstract: BACKGROUND: - @entity10 substantially reduce cardiovascular mortality and appear to have beneficial effects independent of their lipid lowering properties. We evaluated the hypothesis that statin use may modulate the secretion of @entity6 , a well-known contributor to @entity3 . METHODS AND RESULTS: -We measured adrenal hormones in two intervention studies. In study 1 in @entity4 subjects, @entity6 was analyzed at baseline and after @entity8 stimulation (AngII) on both high (HS) and low @entity7 (LS) diets (1122 observations, 15% on @entity10 > 3 months). Statin users had 33% lower @entity6 levels in adjusted models (p < 0.001). @entity5 was not modified by @entity10 . In secondary analyses, the lowest @entity6 levels were seen with lipophilic @entity10 and with higher doses. Statin users had lower blood pressure (BP) and reduced salt sensitivity of BP (p=0.001). In study 2, @entity6 was measured in @entity1 @entity0 on a HS diet, before and after AngII stimulation (143 observations, 79% @entity10 users). Again, statin users had 26% lower @entity6 levels (p =0.006), particularly those using lipophilic @entity10 . Ex vivo studies in @entity2 adrenal glomerulosa cells confirmed that lipophilic @entity10 acutely inhibited @entity6 , but not @entity9 , in response to different secretagogues. CONCLUSIONS: -Statin use among @entity4 and @entity1 subjects was associated with lower @entity6 secretion in response to AngII and LS diet in two @entity0 intervention studies. This effect appeared to be most pronounced with lipophilic @entity10 and higher doses. Future studies to evaluate whether @entity6 inhibition may partially explain the robust cardioprotective effects of @entity10 are warranted.

title: Statin Use and Adrenal XXXX Production in @entity4 and @entity1 Subjects.

answer: @entity6