abstract: BACKGROUND: Primary aldosteronism (PA) is a major cause of secondary @entity1 , and is strongly associated with high morbidity and mortality of @entity0 . @entity4 excess may influence mineral homeostasis through higher urinary @entity2 ( @entity5 ) excretion, reduce @entity2 plasma levels, and lead to secondary increase of @entity3 ( @entity3 ). The purpose of the present study is to clarify the association of serum @entity3 and @entity5 levels with PA in a meta-analysis. METHODS: We identified relevant studies by searching Pubmed, OVID and Sciencedirect (up to September 2014). Studies that met our predefined criteria were included. RESULTS: Six articles from 8 case-control studies were included, involving 748 subjects. Overall, the pooled analyses indicated that subjects with PA had significantly higher serum @entity3 concentrations and lower @entity5 levels than controls with essential @entity1 (EH) ( @entity3 : SMD=1.146, 95% CI=[0.774,1.518]; @entity5 : SMD=-0.698, 95% CI=[-1.102,-0.294]). Subgroup analysis stratified by type of @entity5 measurement found a similar pattern by spectrophotometry (SMD=-1.078, 95% CI=[-1.532,-0.623]), but not by ion selective electrode (SMD=-0.248, 95%CI=[-0.810,0.315]). Sensitivity analysis showed that the results were not materially changed in the leave-one-out analyses by omitting one study in turn. No evidence of publication bias was observed. CONCLUSIONS: This meta-analysis supports a significant association of @entity3 and @entity5 concentration with PA. Metabolic and cardiovascular implications of such an association should be noted in the clinical practice. More mechanistic studies are needed to further explain the association between @entity3 and @entity5 concentration and RA.

title: The association of serum @entity3 and XXXX levels with primary aldosteronism: a meta-analysis.

answer: @entity2


abstract: A survey of Australian assisted reproduction technique (ART) units revealed many (> 50%) use @entity3 of the follicle in addition to direct @entity2 of the fluid during oocyte retrieval. The rationale is that @entity3 offers an advantage to the @entity0 , with a larger number of oocytes being collected and thus a higher potential for pregnancy Following a complication in a @entity0 , the medical staff determined that @entity3 might have been implicated. While this was later shown to be unfounded, the unit changed the method of oocyte collection, thus providing an opportunity historically to evaluate the differences between @entity2 of follicular fluid alone or with additional @entity3 of each follicle. Thus the aim of this analysis was to test the hypothesis that @entity2 alone does not effect the outcomes of ART with respect to oocyte numbers collected, their quality and subsequent fertilisation, or ultimate pregnancy rate in a large @entity0 group (n = 2378). During the review period (1991-1993) the manufacturer of the @entity2 needles; the pump and pressure used for @entity2 ; the staff involved in all procedures; and the premises, equipment and media used for oocyte collection and culture remained constant. Similarly the two @entity0 groups did not differ in their demographics and physical characteristics. There was no difference (p > 0.5) in the number of oocytes collected, the number of embryos created or the pregnancy rate for that treatment cycle. There was also no significant difference between the two groups in fertilisation rates, irrespective of the type of treatment being used @entity1 ( @entity1 ), gamete intrafallopian transfer (GIFT) or intracytoplasmic sperm injection (ICSI)). The data presented in this paper are not prospective. They use historical comparison and are confounded by minor changes in ovarian stimulation protocols, but the conclusions are still valid. These data suggest there is no difference in the outcome of ART (from oocyte collection through to pregnancy rate) whether or not @entity2 of follicles is accompanied by @entity3 . First principles of surgery advocate the shortest possible operating time, the simplest procedure and minimum amount of tissue handling as maxims for reducing complication. Therefore, as a routine, @entity3 would seem superfluous in ART.

title: Follicular XXXX at oocyte retrieval: a reappraisal.

answer: @entity3


abstract: BACKGROUND: Only few reports exist on @entity2 that require cardiopulmonary bypass during resection. We aimed to investigate the early and late clinical outcome of these @entity0 . METHODS: @entity0 with @entity2 that underwent surgery between 2002 and 2014 were analyzed. All @entity0 had cardiopulomonary bypass support during resection. Clinical and perioperative data was retrospectively reviewed for outcome and overall survival. RESULTS: Fifteen @entity0 (12 female, mean age of 55        15  years, range 24 to 80  years) were identified. Eleven (8 female) were diagnosed with primary @entity4 and four with @entity1 . Three @entity0 died early postoperatively. @entity0 diagnosed with @entity3 had a significantly worse outcome than non- @entity3 @entity0 (83.3        15.2  % after 1  year, 31.3        24.5  % after 5  years vs. 83.3        15.2  % after 1  year, 0        0  % after 5  years, p   =   0.005). CONCLUSIONS: Malignancies with extension into cardiac structures or infiltration of great vessels can be resected with cardiopulmonary bypass support and tolerable risk. Carefully selected @entity0 can undergo advanced operative procedures with an acceptable 1-year-survival, but only few @entity0 achieved good long-term outcome.

title: Resection of XXXX infiltrating cardiac structures with use of cardiopulmonary bypass.

answer: @entity2


abstract: UNASSIGNED: Existing vital health statistics registries in India have been unable to provide reliable estimates of maternal and newborn mortality and morbidity, and region-specific health estimates are essential to the planning and monitoring of health interventions. This study was designed to assess baseline rates as the precursor to a community-based cluster randomized control trial (cRCT)-Community Level Interventions for @entity2 (CLIP) Trial (NCT01911494; CTRI/2014/01/004352). The objective was to describe baseline demographics and health outcomes prior to initiation of the CLIP trial and to improve knowledge of population-level health, in particular of maternal and neonatal outcomes related to @entity1 disorders of pregnancy, in northern districts the state of Karnataka, India. The prospective population-based survey was conducted in eight clusters in Belgaum and Bagalkot districts in Karnataka State from 2013-2014. Data collection was undertaken by adapting the Maternal and Newborn Health registry platform, developed by the Global Network for @entity0 's and @entity0 Health Studies. Descriptive statistics were completed using SAS and R. During the period of 2013-2014, prospective data was collected on 5,469 pregnant @entity0 with an average age of 23.2 (+/-3.3) years. Delivery outcomes were collected from 5,448 completed pregnancies. A majority of the @entity0 reported institutional deliveries (96.0%), largely attended by skilled birth attendants. The maternal mortality ratio of 103 (per 100,000 livebirths) was observed during this study, neonatal mortality ratio was 25 per 1,000 livebirths, and perinatal mortality ratio was 50 per 1,000 livebirths. Despite a high number of institutional deliveries, rates of stillbirth were 2.86%. Early enrollment and close follow-up and monitoring procedures established by the Maternal and Newborn Health registry allowed for negligible lost to follow-up. This population-level study provides regional rates of maternal and newborn health in Belgaum and Bagalkot in Karnataka over 2013-14. The mortality ratios and morbidity information can be used in planning interventions and monitoring indicators of effectiveness to inform policy and practice. Comprehensive regional epidemiologic data, such as that provided here, is essential to gauge improvements and challenges in maternal health, as well as track disparities found in rural areas.

title: Maternal and Newborn Health in Karnataka State, India: The Community Level Interventions for XXXX (CLIP) Trial's Baseline Study Results.

answer: @entity2


abstract: UNASSIGNED: Positive-strand RNA [(+) RNA] viruses remodel cellular membranes to facilitate virus replication and assembly. In the case of @entity1 ), the viral membrane protein 6K2 plays an essential role in endomembrane alterations. Although 6K2-induced membrane dynamics have been widely studied by confocal microscopy, the ultrastructure of this remodeling has not been extensively examined. In this study, we investigated the formation of @entity1 -induced membrane changes by chemical fixation and high-pressure freezing/freeze substitution (HPF/FS) for transmission electron microscopy at different times of @entity0 . We observed the formation of convoluted membranes connected to rough endoplasmic reticulum (rER) early in the @entity0 process, followed by the production of single-membrane vesicle-like (SMVL) structures at mid stage of @entity0 . Both SMVL and double-membrane vesicle-like structures with electron-dense cores, as well as electron-dense bodies, were found late in the @entity0 process. Immunogold labeling results showed that the vesicle-like structures were 6K2 tagged, and suggested that only the SMVL structures were viral RNA replication sites. Electron tomography (ET) was used to regenerate a three-dimensional model of these vesicle-like structures, which showed they were in fact tubules. Late in @entity0 , we observed filamentous particle bundles associated with electron-dense bodies, which suggests that these are sites for viral particle assembly. In addition, @entity1 particles were observed to accumulate in the central vacuole as membrane-associated linear arrays. Our work thus unravels the sequential appearance of distinct @entity1 -induced membrane structures for viral RNA replication, viral particle assembly and accumulation. IMPORTANCE: Positive-strand RNA viruses remodel cellular membranes for different stages of the infectious process, such as protein translation and processing, viral RNA synthesis, particle assembly, and virus transmission. The ultrastructure of the @entity1 -induced membrane remodeling was investigated over several days of @entity0 . The first change that was observed involved endoplasmic reticulum-connected convoluted membrane accumulation. This was followed by the formation of single-membrane tubules, which were shown to be viral RNA replication sites. Later in the @entity0 process, double-membrane tubular structures were observed and were associated with viral particle bundles. In addition, @entity1 particles were observed to accumulate in the central vacuole as membrane-associated linear arrays. This work thus unravels the sequential appearance of distinct @entity1 -induced membrane structures for viral RNA replication, viral particle assembly and accumulation.

title: Ultrastructural characterization of XXXX induced cellular rearrangements reveal membrane-bound viral particles accumulating in vacuoles.

answer: @entity1


abstract: @entity1 ( @entity1 ) is an uncommon manifestation of @entity2 . @entity7 of the @entity4 is a rare variation in @entity5 ( @entity5 ), associated with worse prognosis. We present the case of a 56-year-old @entity0 who presented with an inflamed lump on her abdominal wall. Computed tomography (CT) revealed a large mass from the @entity4 invading the abdominal wall. She underwent liver resection with regional lymphadenectomy. Pathology analysis revealed a 12-cm pT3N0 @entity5 . Hospital discharge occurred at post-operative Day 20. She recurred and died 10 months after surgery. Survival after the diagnosis of @entity1 is dismal. The present case was a diagnostic trap. First, the @entity0 's @entity3 presented as a cutaneous abscess and biopsy revealed a @entity6 . A CT scan suggested a continuous mass involving the abdominal wall. @entity1 was only suspected during surgery when no continuity between the @entity2 and the abdominal wall was identified.

title: @entity5 XXXX to the skin   .

answer: @entity7


abstract: UNASSIGNED: Background Delirium is an acute change in mental status characterized by sudden onset, fluctuating course, inattention, disorganized thinking, and abnormal level of consciousness. The objective of the randomized controlled trial "A STrategy to Reduce the Incidence of @entity2 in Elderly @entity0 " (STRIDE) is to assess the effectiveness of light versus heavy sedation on @entity3 and other outcomes in elderly @entity0 undergoing @entity1 repair surgery. Our goal is to describe the design considerations and lessons learned in planning and implementing the STRIDE trial. Methods Discussed are challenges encountered including (1) how to ensure that we quickly identify, assess the eligibility of, and randomize traumatic @entity1 @entity0 ; (2) how to implement interventions that involve continuous monitoring and adjustment during the surgery; and (3) how to measure and ascertain the primary outcome, @entity3 . Results To address the first challenge, we monitored the operating room schedule more actively than anticipated. We constructed and organized eligibility assessment data collection forms by purpose and by source of information needed to complete them. We decided that randomization needs to take place in the operating room. To address the second challenge, we designed and implemented a treatment protocol and covered the bispectral index monitor to prevent the Anesthesiologist/Anesthetist from being influenced by the bispectral index reading while administering the intervention. Finally, clinical assessment of @entity3 consisted of standardized interviews of the @entity0 using validated instruments, interviews of those caring for the @entity0 , and review of the medical record. A consensus panel made the final determination of a @entity3 diagnosis. We note that STRIDE is a single-center trial. The decisions we took may have different implications for multi-center trials. Conclusions Lessons learned are likely to provide useful information to others designing trials in emergency and surgical setting and for those who are interested in unbiased assessment of @entity3 .

title: Design considerations of a randomized controlled trial of sedation level during @entity1 repair surgery: a strategy to reduce the incidence of XXXX in elderly @entity0 .

answer: @entity2


abstract: BACKGROUND: Traumatic events such as disasters, accidents, war, or criminal violence are often accompanied by the loss of loved ones, and may then give rise to traumatic grief. Traumatic grief refers to a clinical diagnosis of @entity1 ( @entity1 ) with comorbid (symptoms of) @entity5 ( @entity5 ) and/or @entity3 ( @entity3 ) following confrontation with a @entity4 . @entity2 survivors, who are frequently from different cultural backgrounds, have often experienced multiple losses and ambiguous loss (missing family members or friends). Current evidence-based treatments for @entity5 do not focus on traumatic grief. OBJECTIVE: To develop a treatment for traumatic grief combining treatment interventions for @entity5 and @entity1 that may accommodate cultural aspects of grief. METHOD: To provide a rationale for treatment, we propose a cognitive stress model of traumatic grief. Based on this model and on existing evidence-based treatments for @entity5 and complicated grief, we developed Brief Eclectic Psychotherapy for Traumatic Grief (BEP-TG) for the treatment of @entity0 with traumatic grief. The treatment is presented along with a case vignette. RESULTS: Processes contributing to traumatic grief include inadequately integrating the memory of the @entity4 , negative appraisal of the @entity4 , sensitivity to matching triggers and new stressors, and attempting to avoid distress. BEP-TG targets these processes. The BEP-TG protocol consists of five parts with proven effectiveness in the treatment of @entity1 , @entity5 , and @entity3 : information and motivation, grief-focused exposure, memorabilia and writing assignments, finding meaning and activation, and a farewell ritual. CONCLUSION: Tailored to fit the needs of @entity2 survivors, BEP-TG can be used to address traumatic grief symptoms related to multiple losses and ambiguous loss, as well as cultural aspects of bereavement through its different components.

title: Brief Eclectic Psychotherapy for Traumatic Grief (BEP-TG): toward integrated treatment of symptoms related to XXXX .

answer: @entity4


abstract: BACKGROUND: No studies have assessed psychopathology among @entity5 ( @entity5 ) @entity0 . The General Health Questionnaire allows for distinguishing @entity0 suffering from @entity2 problems from those in good mental health. OBJECTIVE: To assess the @entity2 in Saudi @entity0 with @entity5 . METHODS: The study was cross-sectional in nature. Institutional ethics committee approval and individual informed consent from study @entity0 were obtained. Fifty @entity0 with @entity5 with unknown @entity2 were given the General Health Questionnaire-28 (GHQ-28) questionnaire to complete. RESULTS: Complete data were available for 50 @entity0 . Thirty @entity0 (60%) with @entity5 scored above the conventional threshold. Their subgroups were: somatic complaints 28%, @entity3 and @entity1 28%, social dysfunction 34%, and severe @entity4 10%. CONCLUSIONS: Greater attention needs to be paid to @entity5 @entity0 . Vulnerable female @entity0 may have high levels of @entity2 symptomatology that may benefit from assessment and intervention.

title: Comorbid XXXX conditions of @entity5 .

answer: @entity2


abstract: The high local failure rate in @entity0 with locally advanced @entity1 treated with standard radiation has spurred interest in radiosensitization. @entity2 is the most active single chemotherapeutic agent in squamous @entity1 , and is considered to be a radiosensitizer. Based on a previous single-institution study looking at continuous low-dose intra-arterial @entity2 given throughout planned radiation therapy in @entity0 with advanced @entity1 , the Gynecologic Oncology Group initiated a limited access pilot study to assess the feasibility of this treatment method for a group-wide study. @entity0 with locally advanced squamous @entity1 and surgically documented negative periaortic lymph nodes were eligible for the study. During surgical staging, the catheters of a totally implantable pump were placed in the internal iliac arteries. The pump was filled with @entity2 which was delivered at 4.5-6.5 mg day-1 continuously throughout both external radiation and brachytherapy. Drug distribution through the catheters was determined using radiolabelled macro-aggregated albumin particles. Three of nine evaluable @entity0 were free of disease at follow-up. Drug distribution was less than optimal through 4.6% of the pump catheters. Five @entity0 had premature discontinuation of the @entity2 for various reasons. These problems resulted in low accrual and subsequent closure of the study. This treatment method is not feasible for a phase III evaluation on a group-wide basis.

title: Continuous intra-arterial @entity2 combined with radiotherapy in locally advanced squamous XXXX : a Gynecologic Oncology Group pilot study.

answer: @entity1


abstract: BACKGROUND: Dietary induction of @entity6 ( @entity6 ) can reduce @entity4 in @entity0 with @entity2 . @entity0 with @entity1 may suffer from @entity4 with a prominent secretory component. We studied if @entity6 -therapy could affect this type of @entity4 . METHODS: Six @entity0 with the midgut @entity7 and two with metastasizing @entity3 ( @entity3 ) participated. Effects of intake of @entity6 , in the form of @entity6 -rich egg powder ( @entity6 -egg), and induction of endogenous @entity6 -activity by intake of specially processed cereals (SPCs) were studied. In an initial open part of the study all @entity0 received @entity6 -egg for 4 weeks, followed by a double-blind crossover period with SPC and control cereals (CCs) for 6 weeks each. Daily number of bowel movements at the end of each treatment period was registered. RESULTS: Treatment with @entity6 -egg resulted in a @entity5 in seven @entity0 (P<0.01). Registrations of bowel movements from both SPC and CC diet periods were obtained from five @entity0 . The daily number of bowel movements was lower during the SPC-period compared to the period with CC (P<0.05). All @entity0 had low levels of @entity6 -activity in serum at baseline. During treatment with @entity6 -egg, the mean level increased slightly. @entity6 -activity was higher (P<0.05) after SPC compared to the CC diet. CONCLUSIONS: In a group of @entity0 with endocrine @entity4 , @entity6 -activity could be induced, and @entity6 -therapy reduced the number of bowel movements.

title: Antisecretory factor counteracts secretory XXXX of endocrine origin.

answer: @entity4


abstract: AIM: To identify characteristics of neuropsychological function among elderly individuals with @entity2 ( @entity2 ) and evaluate domain-specific effects of T2DM on cognition. METHODS: This was a cross-sectional study conducted in Tianjin, China. MCI subjects (n=246) and controls were identified in elderly individuals with @entity1 , and groups were matched in a 1:1 ratio for sex, age and educational level. Cognitive function was assessed using WAIS-III (block design, digit span), @entity4 Making Test A, @entity4 Making Test B, @entity5 -III (word list learning, logical memory), verbal fluency and MMSE. We used multivariable logistic regression to find @entity1 factors associated with MCI. RESULTS: The mean MMSE score was 22.73  2.32 in subjects with @entity2 , versus 26.71  2.43 in subjects cognitive normal (P<0.001). Executive and visuospatial functions were more impaired in individuals with @entity2 than in those without, as assessed using block design (P<0.001), digit span test (P<0.001), and Trails B (P<0.001). For memory, subjects with @entity2 did worse than those cognitive normal on the word learning list delayed recall (P=0.015). @entity1 -related factors such as longer duration of T2DM, higher HbA1c, insulin treatment was associated with a lower level of cognitive functioning using MMSE, block design, delayed recall and Trails B test. CONCLUSIONS: T2DM should be considered a risk factor for MCI. This risk may be associated with duration of @entity1 , use of @entity3 -lowering medications, degree of @entity3 control. To decrease risk of MCI, it is important to monitor @entity3 control and adjust medications appropriately in elderly @entity0 .

title: The characteristic of cognitive function in XXXX .

answer: @entity1


abstract: Qualitative abnormalities of spontaneous motor activity in newborns and young @entity0 are early predictive markers for later @entity1 . Aim of this research was to identify which motor patterns may be specific for later @entity1 . In a large, prospectively performed longitudinal study involving four European hospitals we identified twelve cases with the relatively rare condition of @entity1 and compared their early motor development with twelve @entity1 cases and twelve controls. From birth to the fifth month post-term, all @entity0 were repeatedly videoed and their spontaneous motor patterns, including general movements, were assessed. Until the second month post-term, the @entity0 that later became @entity2 displayed a poor repertoire of general movements, "arm movements in circles" and finger spreading. Abnormal arm and finger movements remained until at least five months and were then concurrent with a lack of arm and leg movements towards the midline. Later @entity2 @entity0 share with later spastic @entity0 the absence of fidgety movements, a spontaneous movement pattern that is normally present from three to five months. Qualitative assessment of spontaneous motor patterns enabled us to identify @entity0 at high risk for @entity1 early in life. Additionally, we were able to discriminate them from those @entity0 at high risk for later @entity1 . This is a matter of significant clinical relevance because the two types of @entity1 ask for different management and early intervention.

title: The early markers for later XXXX are different from those for @entity1 .

answer: @entity1


abstract: BACKGROUND AND AIMS: The association between hygiene and prevalence of @entity3 has been attributed in part to @entity2 . A pilot study of experimental @entity2 with the hookworm @entity6 was undertaken among a group of otherwise healthy @entity0 with celiac disease to test the potential of the helminth to suppress the immunopathology induced by gluten. METHODS: In a 21-week, double-blinded, placebo-controlled study, we explored the effects of @entity6 @entity2 in 20 healthy, helminth-na  ve adults with celiac disease well controlled by diet. Staged cutaneous inoculations with 10 and 5 infective 3(rd) stage hookworm larvae or placebo were performed at week-0 and -12 respectively. At week-20, a five day oral @entity5 challenge equivalent to 16 grams of gluten per day was undertaken. Primary outcomes included duodenal Marsh score and quantification of the immunodominant a-gliadin peptide (QE65)-specific systemic interferon-y-producing cells by ELISpot pre- and post- @entity5 challenge. RESULTS: Enteric colonisation with hookworm established in all 10 cases, resulting in transiently @entity1 in 5. @entity2 was asymptomatic, with no effect on hemoglobin levels. Although some duodenal @entity4 was apparent, hookworm-infected mucosa retained a healthy appearance. In both groups, @entity5 challenge caused deterioration in both primary and several secondary outcomes. CONCLUSIONS: Experimental @entity6 @entity2 proved to be safe and enabled testing its effect on a range of measures of the @entity0 autoimmune response. Infection imposed no obvious benefit on pathology. TRIAL REGISTRATION: ClinicalTrials.gov NCT00671138.

title: Effect of hookworm infection on XXXX challenge in celiac disease--a randomised double-blinded placebo controlled trial.

answer: @entity5


abstract: In model organisms both the nutrition of the mother and the young offspring could induce long-lasting transcriptional changes in tissues. In livestock, such changes could have important roles in determining nutrient use and meat quality. The main objective was to evaluate if plane of maternal nutrition during late-gestation and weaning age alter the offspring's Longissimus muscle (LM) transcriptome, animal performance, and metabolic hormones. Whole-transcriptome microarray analysis was performed on LM samples of early (EW) and normal weaned (NW) Angus * Simmental @entity0 born to grazing @entity0 receiving no supplement [low plane of nutrition (LPN)] or 2.3 kg high-grain mix/day [ @entity1 ( @entity1 )] during the last 105 days of gestation. Biopsies of LM were harvested at 78 (EW), 187 (NW) and 354 (before slaughter) days of age. Despite greater feed intake in @entity1 offspring, blood insulin was greater in LPN offspring. Carcass @entity2 content was greater in EW offspring. Bioinformatics analysis of the transcriptome highlighted a modest overall response to maternal plane of nutrition, resulting in only 35 differentially expressed genes (DEG). However, weaning age and a high-grain diet (EW) strongly impacted the transcriptome (DEG = 167), especially causing a lipogenic program activation. In addition, between 78 and 187 days of age, EW steers had an activation of the innate immune system due presumably to macrophage infiltration of @entity2 . Between 187 and 354 days of age (the "finishing" phase), NW steers had an activation of the lipogenic transcriptome machinery, while EW steers had a clear inhibition through the epigenetic control of histone acetylases. Results underscored the need to conduct further studies to understand better the functional outcome of transcriptome changes induced in the offspring by pre- and post-natal nutrition. Additional knowledge on molecular and functional outcomes would help produce more efficient beef @entity0 .

title: Maternal Plane of Nutrition during Late Gestation and Weaning Age Alter Angus * Simmental Offspring Longissimus Muscle Transcriptome and XXXX .

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) is a chronic @entity3 of unknown aetiology, which when left untreated can lead to liver @entity1 and @entity6 . Current treatment strategies include long-term treatment with @entity2 and/or @entity4 . Most @entity0 respond well to immunosuppressive therapy and treatment usually results in an asymptomatic course of @entity5 in remission. Nevertheless, both drugs are associated with serious side effects that can sometimes be severe and may necessitate drug withdrawal. Whether or not treatment in @entity0 who are in longstanding remission can be discontinued is unknown. Key Messages: Available data rely on retrospective data sets and are not conclusive. Some studies indicate that a sustained remission after treatment withdrawal is feasible, whereas other studies have found relapse rates in up to 90% of @entity0 , even in @entity0 with established histological remission. @entity0 who relapse after drug withdrawal have a high probability for a re-relapse to occur. Life-long maintenance therapy should be strongly considered in these @entity0 , since @entity0 who have multiple relapses are more likely to progress to @entity1 , @entity3 . CONCLUSION: For a majority of @entity0 , @entity5 is a lifelong disease requiring permanent treatment. @entity0 in longstanding clinical remission on monotherapy, with complete normalisation of aminotransferases and IgG could be offered one attempt of drug withdrawal. The risk of disease progression after a single relapse appears low, while a @entity0 's realization that infinite maintenance therapy is mandatory may improve drug adherence.

title: Treatment Withdrawal in XXXX .

answer: @entity5


abstract: AIM: To investigate the correlation between clinical, high frequency ultrasound biomicroscopy (UBM) and, where possible, histological findings in cases of @entity3 presenting to the departments of ophthalmology, Great Ormond Street Hospital for @entity0 , London, and the Hospital for Sick @entity0 , Toronto, Canada. METHOD: 22 eyes of 13 @entity0 (age range 3-225 days) with congenitally opaque corneas were examined. UBM was performed using the ultrasound biomicroscope (Allergan-Humphrey). All eyes underwent penetrating keratoplasties (PKP) except five. The host corneas were all sent for histological examination. RESULTS: The final diagnosis in our series was @entity6 in nine cases (70%), @entity4 in two cases (15%), and @entity8 in two cases (15%). The UBM findings changed the clinical diagnosis in five cases (38%). In these five cases histology was available in four and confirmed the UBM diagnosis in each case. In no case of the 13 where histology was available did it contradict the UBM findings. In two cases a hypoechoic region in the anterior stroma was seen on UBM which correlated histologically with absent Bowman's layer and @entity1 . In two cases UBM revealed @entity5 and in one, @entity9 , which was not apparent clinically. CONCLUSION: UBM examination is not only very useful in evaluating the clinical diagnosis in @entity3 , it also acts as a preoperative guide in cases undergoing PKP by detecting keratolenticular and @entity7 and other @entity2 such as @entity5 and @entity9 . In all cases where PKP was performed the UBM diagnosis was confirmed histologically. The clinical diagnosis was incorrect in five cases. This has important implications in studies of phenotype/genotype correlation of @entity3 .

title: Clinicopathological correlation of XXXX using ultrasound biomicroscopy.

answer: @entity3


abstract: BACKGROUND: In a new health care economy, there is an emerging need to understand and quantify predictors of @entity3 ( @entity3 ) outcomes. We investigated the association between preoperative radiographic disease (as measured quantitatively by joint space width [JSW]) and @entity0 -reported function, activity, @entity1 , and quality of life after @entity3 . METHODS: We retrospectively analyzed 146 @entity0 (146 hips) 55 years or younger with a diagnosis of @entity2 who underwent cementless @entity3 between January 2009 and December 2010. Preoperative pelvic radiographs were measured by 1 author blinded to clinical outcomes to establish JSW, defined as the shortest distance between the femoral head margin and the superolateral weight-bearing portion of the acetabulum. The JSW value was treated as a continuous variable when applied to statistical modeling. The relationship between the JSW and the improvement of clinical outcome was examined via a general linear modeling approach with adjustments for @entity0 ' age, body mass index, and sex. RESULTS: We identified an inverse relationship between preoperative JSW and improvements in functional, activity, @entity1 , and quality of life. We found that, as JSW decreased by 1 mm, the outcome measure improvements were modified Harris Hip Score of 6.3 (p<0.001); SF-12 physical: 2.1 (p=0.027); WOMAC- @entity1 : 4.8 (p=0.01); and UCLA Activity: 0.44 (p=0.02). CONCLUSIONS: Our results demonstrate that @entity0 with greater preoperative joint space have less predictable improvement in terms of function, @entity1 relief, and activity. These findings suggest that @entity3 in young @entity0 with a JSW less than 1.5 to 2 mm provides more predictable improvements in @entity1 and functional outcomes.

title: Preoperative Joint Space Width Predicts @entity0 -Reported Outcomes After Total Hip Arthroplasty in Young XXXX .

answer: @entity0


abstract: AIM: To investigate the efficacy and safety of @entity2 and @entity6 salt, with or without trastuzumab, in @entity0 with locally advanced or metastatic @entity4 overexpressing @entity9 . METHODS: The main eligibility criterion was @entity9 overexpression on immunohistochemistry (IHC 2+ or 3+) of primary @entity1 tissue confirmed by fluorescence in situ hybridisation (FISH). @entity0 were randomised to Arm A: @entity2 1000mg/m(2) (days 1 and 8) plus either @entity5 (70mg/m(2)) or @entity10 (AUC=5) (day 1 every 3weeks) or Arm B: added trastuzumab (8mg/kg loading dose, then 6mg/kg every 21days until progression). The primary end-point was progression-free survival (PFS). RESULTS: Among 563 screened @entity0 , 75 (13.3%) were @entity9 positive (IHC 2+/3+ and FISH+) and 61 met all eligibility criteria (median age, 64years; 54/61 males; 50/61 baseline ECOG-PS 0-1; 11 locally advanced and 50 metastatic). There was no significant difference between Arms A and B in median PFS (10.2 versus 8.2months, respectively, p=0.689), objective response rate (65.5% versus 53.2%, p=0.39), and median overall survival (15.7 versus 14.1months, respectively, p=0.684). In an exploratory analysis, trastuzumab-treated @entity0 receiving @entity5 rather than @entity10 -based chemotherapy fared better (PFS: 10.6 versus 8.0; OS: 33.1 versus 9.5months). Myelosuppression was the main grade 3/4 @entity3 . A case of grade 3 @entity7 and one death from @entity8 occurred in arm B. CONCLUSION: The unexpectedly low incidence of @entity9 overexpression precluded the detection of a significant difference in efficacy on addition of trastuzumab to @entity6 -based chemotherapy with @entity2 . However, the satisfactory tolerance of the combination warrants further studies, especially of the @entity5 -based combination, in well-defined @entity0 subsets.

title: Multicentre randomised phase II trial of @entity2 + XXXX , with or without trastuzumab, in advanced or metastatic @entity4 overexpressing @entity9 .

answer: @entity6


abstract: BACKGROUND: The Portsmouth Physiological and Operative Severity Score for enUmeration of Mortality and morbidity (P-POSSUM) equation permits comparative audit that allows for differences in case mix. The methodology has previously been shown accurately to model general surgical and vascular surgical @entity0 . @entity0 with a @entity3 ( @entity2 ) are, however, very different from elective @entity0 and it may be hypothesized that they require their own specific risk model. METHODS: POSSUM data on 444 (213 emergency, 231 elective) admissions for @entity2 surgery between August 1993 and July 2000 were analysed using the P-POSSUM equation for general surgery and the P-POSSUM equations developed for vascular surgery. RESULTS: All equations successfully modelled the elective @entity1 but failed to fit the @entity1 , and the elective and @entity1 combined. This suggested that admission method (not a POSSUM data item) is an important factor for @entity0 with @entity2 . However, with these data it was not possible to generate a model, including admission method, that successfully modelled the combined elective and emergency data. The 213 emergency aneurysm repairs were divided into two groups by operation date. The first 106 (training set) were used to form logistic regression models following the P-POSSUM methodology. These models were found successfully to fit the remaining 107 records (test set) on prospective application (chi2 = 4.50, 4 d.f., P = 0.345). CONCLUSION: Ruptured AAAs appear to be different from elective AAAs and other vascular cases and require their own risk model.

title: Portsmouth POSSUM models for XXXX surgery.

answer: @entity2


abstract: The Belgian severe @entity8 registry is a web-based registry encompassing demographic, clinical, functional and inflammatory data of severe @entity9 (SA), aiming at improving awareness, knowledge on its natural history and subphenotypes, and offering tools to optimize care of this @entity8 population. METHODS: The cross-sectional analyses of this registry included 350 SA as defined by the ATS (2000) from 9 Belgian centres, with at least one year follow up. RESULTS: Mean age was 55      14  yrs. SA were more frequently female (57%) and @entity10 (70%). Late-onset @entity8 (>= 40  yr) was observed in 31% of SA. Current smokers represented 12% while 31% were ex-smokers. In addition to high doses ICS  +  LABA, 65% of @entity0 were receiving @entity16 , 27% anti-IgE and 24% maintenance oral @entity4 (8  mg (Interquartile range-IQR:4-8) @entity12 ). Despite impaired airflow (median FEV1:67%; IQR: 52-81) only 65% had a post-bronchodilator FEV1/FVC ratio <70%. The median blood eosinophil count was 240/mm  . The median FENO was 26  ppb (IQR: 15-43) and 22% of SA had FENO  >=   50  ppb. Induced sputum was successful in 86 @entity0 . @entity13 (sputum Eos  >=   3%) was the predominant phenotype (55%) while neutrophilic (sputum @entity6  >=   76%) and paucigranulocytic @entity8 accounted for 22% and 17% respectively. Comorbidities included @entity14 and chronic rhinosinusitis (49%), @entity11 (19%), @entity7 (36%), overweight and @entity1 (47%) and @entity5 (19%). In addition, 8% had @entity3 -induced @entity8 and 3% @entity15 . Asthma was not well-controlled in 83% according to ACT  <  20 and 77% with ACQ  >  1.5. CONCLUSION: In this cohort of @entity0 with severe @entity8 , the majority displayed indices of persistent airflow limitation and eosinophilic @entity2 despite high-dose @entity4 , suggesting potential for eosinophil-targeted biotherapies.

title: Heterogeneity of phenotypes in severe XXXX . The Belgian Severe Asthma Registry (BSAR).

answer: @entity9


abstract: AIM: The mostly known genotypic virulence features of @entity2 are cytotoxin associated gene A ( @entity5 ) and Vacuoliting cytotoxin gene A (VacA). We investigated the association of these major virulence factors with @entity1 and non- @entity1 @entity3 in our region. METHODS: One hundred and forty two dyspeptic @entity0 were studied (average age 44.8+/-15.9 years, range 15-87 years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of @entity2 . 107 @entity0 who were @entity2 positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal @entity1 (DU), @entity4 (NUD). The polymerase chain reaction (PCR) was used to detect @entity5 and VacA genes of @entity2 using specific primers. RESULTS: @entity2 was isolated from 75.4 % (107/142) of the @entity0 . Of the 107 @entity0 , 66 (61.7 %) were @entity5 -positive and 82 (76.6 %) were VacA-positive. @entity5 gene was positively associated with DU and GU (P<0.01, P<0.02), but not with NUD (P>0.05). Although VacA positivity in @entity1 @entity0 was higher than that in NUD group, the difference was not statistically significant (P>0.05). CONCLUSION: There is a significantly positive association between @entity5 genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our @entity0 .

title: Association of @entity5 and VacA presence with @entity1 and non- @entity1 XXXX in a Turkish population.

answer: @entity3


abstract: PURPOSE: @entity7 tartrate suppositories are used for treatment of @entity5 attacks. @entity1 may lead to severe @entity2 such as ulceration, stricture, and @entity6 . These complications are rare, and only sporadic reports may be found. Nevertheless, awareness of this entity on the part of prescribing physicians and treating colorectal surgeons is essential for a successful outcome, because withdrawal of this medication is an inherent part of treatment. @entity0 : Five female @entity0 were referred for treatment of symptomatic strictures of the anal canal and lower rectum. All of these @entity0 admitted prolonged, nearly daily use of three to seven @entity7 tartrate suppositories. RESULTS: Three @entity0 with severe @entity4 of the anal verge and anal canal were treated by Y-V anoplasty, and two @entity0 with circular stricture of the lower third of the rectum had balloon dilatations. In all @entity0 the use of @entity7 suppositories was stopped, and alternative medication was instituted. Long-term follow-up (3-12 years) showed complete resolution of symptoms. CONCLUSION: In view of the availability of new effective drugs for treatment of @entity5 ( @entity3 agonists) and considering the potentially severe complications of chronic use of @entity7 , the use of this medication should be abandoned.

title: XXXX -induced anorectal strictures: report of five cases.

answer: @entity7


abstract: Light-at-night exposure enhances the risk of @entity0 . @entity2 is among the most @entity0 affecting humankind. Physical exercise has shown positive effects against @entity2 . Here, we investigated whether pineal gland modulates antipreneoplastic effects of physical exercise in the colon. Surgical and non-surgical @entity3 were performed to clarify the relationship between the pineal gland activity and manifestation of @entity4 . Next, a progressive swimming training was applied in @entity1 exposed or not to either @entity3 or carcinogen treatment for 10 weeks. Both surgical and non-surgical @entity3 increased the development of @entity2 . It was further found that impairing the pineal gland function, higher rates of DNA damage were induced in colonic epithelial and enteric glial cells. Physical exercise acted positively against preneoplasia, whereas impairing the pineal function with constant light exposure disrupts its positive effects on the development of @entity5 in the colon. This was yet related to increased DNA damage in glial cells and enteric neuronal activation aside from serum @entity6 levels. Our findings suggest that protective effects of physical exercise against @entity2 are dependent on the pineal gland activity.

title: Pineal gland function is required for colon antipreneoplastic effects of physical exercise in XXXX .

answer: @entity1


abstract: OBJECTIVE: Based on the 7-years results, assess the interest of organised @entity1 screening on regional level (the EVE campaign). ORGANISATION AND METHOD: The screening relied on existing medical structures. The centralised data collection, with data from the cyto-pathology laboratories assessed the quality of screening and the participation of the @entity0 to the follow-up of abnormal smears. The campaign run by a local @entity0 's rights association and sponsored by National educational and health information funds (FNPEIS) and the local councils. RESULTS: To date, 814 649 smears in the Bas-Rhin and 62 227 in the Haut-Rhin have been collected. After 3 years, 72% of @entity0 aged 25 to 64 in the year 1997, in the Bas-Rhin, had had at least one smear, and 82% after 5 years. Inadequate smears represented less than 1% of all smears of the region. Pathological smears represented around 4% of the total and benefited from strict monitoring which could be improved. However this could be improved on since only 75% of @entity0 in whom a low-grade lesion was suspected underwent a second examination within the year that followed. The rate was on 80% for those with suspected high-grade lesions. Reminders made by the EVE association, in agreement with practitioners, permitted postponed follow-up and improved screening coverage. CONCLUSION: The EVE programme clearly shows that organized screening is feasible in France because the results obtained are satisfactory in terms of screening coverage and quality of smears. Centralised data collection permits detection of possible weak points and contributes to the improvement in efficacy.

title: [EVE, a regional campaign for the screening of XXXX . Organization, 7-years results and perspectives].

answer: @entity1


abstract: BACKGROUND: Inflammation is involved in all stages of development of @entity3 . Currently, percutaneous coronary intervention (PCI) is a  widely used method of treatment of @entity1 ( @entity1 ) when combined with @entity4 ( @entity4 ). However, there is still controversy over invasive versus optimal pharmacological treatment in @entity1 ( @entity1 ). Systemic inflammatory response triggered by PCI may limit its effectiveness in @entity0 with @entity1 . OBJECTIVES: We aimed to evaluate plasma @entity6 and its relation to @entity2 generation and platelet reactivity both early after the procedure and in a  one-month observation following successful PCI with stent implantation, in @entity0 with @entity1 and @entity4 , including statins. MATERIAL AND METHODS: We conducted a  prospective study, in which @entity6 , platelet activation, @entity2 generation and time course of prothrombin activation were determined at baseline, 3-5  days and 30  days after successful PCI with stent implantation, in 50 consecutive @entity0 with @entity1 , on chronic statin therapy. RESULTS: Early after PCI @entity6 increased by 176% as compared with baseline (p  <  0.001) and one-month after angioplasty @entity6 was still 54% higher than before the procedure (p  =  0.002). In multivariate model prolonged increase in @entity8  month after PCI was independently associated with @entity7 -reactivity index (PRI) (p  =  0.04) and maximum concentration of @entity2 (p  =  0.003), both measured 30  days after the procedure. CONCLUSIONS: Post-procedural @entity6 increase, which persists at least one month in @entity0 with @entity1 , after elective PCI with stent implantation, is one of the main finding of our study. We demonstrated the relationship between prolonged post-PCI inflammatory reaction, reflected by elevated @entity6 , and increased @entity2 generation and low platelets' response to @entity5 , which may account for limited benefits of PCI in stable coronary @entity0 . It may be advisable to assay post-procedural @entity6 in each @entity0 with @entity1 , who underwent PCI to predict those, with potentially low response to @entity5 .

title: Prolonged XXXX Increase After Percutaneous Coronary Intervention Is Associated with High @entity2 Concentrations and Low Platelet' Response to @entity5 in @entity0 with Stable Angina.

answer: @entity6


abstract: This editorial comments on two similar reviews of the literature on @entity0 and post-menopausal hormone therapies (HTs), puts the results in clinical perspective and suggests where they direct future research and clinical management. Although epidemiological studies have suggested increased @entity0 risk for all menopausal @entity2 regimens, unopposed oral @entity3 regimens have not been associated with any increased risk in recent randomized placebo controlled trials (RCTs). Added progestogen after 5 years of combined @entity2 in RCTs increases the risk of @entity0 by four cases per 10,000 per annum. As yet there is no evidence of different risk by progestogen type, dose or route. Theoretically local intrauterine progestogen may not give the same risk, but long-term trials are required. The commentary addresses the responsibility of the media in presenting levels of risk to the public, moving towards safer regimens, safer therapies, appropriate @entity1 choice and, in particular, correct timing of @entity2 where it is prescribed around menopause. This is in contrast to many of the trials when @entity2 was administered after the potential climacteric window of therapeutic opportunity. The current main indication for @entity2 remains for menopausal symptom control where it improves quality of life. @entity2 may be required for many years. The informed @entity1 should decide on @entity2 based on her personal benefits and risks, which should include all aspects of her health.

title: Current status of hormone therapy and XXXX .

answer: @entity0


abstract: In this study, the spontaneous dwarf @entity0 (SDR) has been used to examine @entity6 production and action in the selective absence of endogenous @entity5 . This dwarf model is unique in that @entity5 is not produced because of a point mutation in the @entity5 gene. However, other pituitary hormones are not obviously compromised. Examination of the hypothalamic pituitary-axis of SDRs revealed that @entity6 messenger RNA (mRNA) levels were increased, whereas @entity2 (SS) and @entity4 (NPY) mRNA levels were decreased, compared with age- and sex-matched normal controls, as determined by Northern blot analysis (n = 5 animals/group; P < 0.05). The elevated levels of @entity6 mRNA in the SDR hypothalamus were accompanied by a 56% increase in pituitary @entity7 ( @entity7 ) mRNA, as determined by RT-PCR (P < 0.05). To investigate whether the up-regulation of @entity7 mRNA resulted in an increase in @entity7 function, SDR and control pituitary cell cultures were challenged with @entity6 (0.001-10 nM; 15 min), and intracellular @entity1 concentrations were measured by RIA. Interestingly, SDR pituitary cells were hyperresponsive to 1 and 10 nM @entity6 , which induced a rise in intracellular @entity1 concentrations 50% greater than that observed in control cultures (n = 3 separate experiments; P < 0.05 and P < 0.01, respectively). Replacement of @entity5 , by osmotic minipump (10 microg/h for 72 h), resulted in the suppression of @entity6 mRNA levels (P < 0.01), whereas SS and NPY mRNA levels were increased (P < 0.05), compared with vehicle-treated controls (n = 5 animals/treatment group). Consonant with the fall in hypothalamic @entity6 mRNA was a decrease in pituitary @entity7 mRNA levels. Although replacement of @entity3 ( @entity3 ), by osmotic pump (5 microg/h for 72 h), resulted in a rise in circulating @entity3 concentrations comparable with that observed after @entity5 replacement, @entity3 treatment was ineffective in modulating @entity6 , SS, or NPY mRNA levels. However, @entity3 treatment did reduce pituitary @entity7 mRNA levels, compared with vehicle-treated controls (P < 0.05). These results further validate the role of @entity5 as a negative regulator of hypothalamic @entity6 expression, and they suggest that SS and NPY act as intermediaries in @entity5 -induced suppression of hypothalamic @entity6 synthesis. These data also demonstrate that increases in circulating @entity3 are not responsible for changes in hypothalamic function observed after @entity5 treatment. Finally, this report establishes modulation of @entity7 synthesis as a component of @entity5 autofeedback regulation.

title: Hypothalamic/pituitary-axis of the spontaneous dwarf @entity0 : autofeedback regulation of XXXX ( @entity5 ) includes suppression of @entity5 releasing-hormone receptor messenger ribonucleic acid.

answer: @entity5


abstract: The present report deals with the behaviour of mast cells in @entity0 in the course of @entity5 @entity1 by the strains. @entity0 weighing about l6 gm were used for three experimental groups; control, sham @entity1 and experimental. The experimental group was infected with @entity5 trophozoites directly into cecum by laparotomy. Strains isolated from three hepatic amoebic abscess cases were used. Mesenteric samples from the region of terminal ileum were fixed in @entity2 and stained with Pugh's solution. The @entity3 in cecum were examined. Changes in number and structure of mesenteric mast cells and blood eosinophils were as follows. 1. The number of mast cell in mesenteric tissues of the infected group increased from first day of the @entity1 and persisted up to 34th day of the observation period. 2. Degranulation and disruption of mast cells increased in the infected group compared with groups of the sham operation and the contro1, but showed no difference by the strains of @entity5 . 3. The blood @entity4 was observed in the infected group and persisted until the observation period. 4. Ulcers in cecum were found in all the infected groups. The results above indicate that mast cells are keenly related with the course of @entity5 @entity1 .

title: [Behaviour Of Mast Cells In XXXX In The Course Of @entity5 Infection By Strains]

answer: @entity0


abstract: AIMS: To describe the prevalence of @entity2 and other @entity5 and @entity3 2 @entity1 risk factors by age and ethnic group in Pacific Island communities and to determine the associations between these risk factors and body mass index. METHODS: Cross-sectional data from commuity-based intervention projects were combined to provide anthropometric, blood sample and blood pressure data on 1,175 Pacific Islands @entity0 (467 @entity0 , 708 @entity0 ) aged 20 years and over from church communities in South, Central and West Auckland. Self-reported data on @entity1 status and leisure-time physical activity were also collected. RESULTS: Based on an ethnic-specific mass index (BMI) cut-off (> 32 kg/m2), 45% of @entity0 and 66% of @entity0 were @entity2 . The age-standardised prevalence of known @entity1 was 12%. @entity0 and @entity0 aged 40-60 years had the highest risk factor levels and were the most sedentary. Tongans had higher risk factor levels than Samoans. In @entity0 , BMI and waist circumference were associated (p<0.05), in the direction of greater disease risk, with blood pressure and concentrations of total @entity4 , HDL- @entity4 , LDL- @entity4 , @entity7 , and blood @entity6 . In @entity0 , these associations were similar but less consistent. CONCLUSIONS: While these data are not representative for all Pacific @entity0 living in New Zealand, they do show an extremely high prevalence of @entity2 and significant associations between @entity2 and other cardiovascular risk factors. These communities warrant a very high priority as part of public health efforts to address New Zealand's growing @entity2 epidemic.

title: Heart disease and XXXX risk factors in Pacific Islands communities and associations with measures of body fat.

answer: @entity1


abstract: Neonatal lesion of the primary afferents in the infraorbital nerve causes the @entity0 of one-third of the neurons in the second-order target, the principal sensory nucleus of the trigeminal nerve (PSN). We examined the expression of two candidate ' @entity0 ' proteins, @entity2 and the antigen recognized by the antibody ALZ-50, in the normal and deafferented PSN. In addition, the effect of neonatal transection of the infraorbital nerve (a major component of the trigeminal nerve) on protein expression was examined. The expression of @entity3 in the developing PSN was also studied as an index of metabolic activity. Protein expression was measured using quantitative analyses of immunoblots and immunohistochemical preparations. The expression of @entity2 - and ALZ-50-immunoreactivity in the normal PSN peaked during the first postnatal week. Transection of the infraorbital nerve directly affected the expression of @entity2 and the ALZ-50-positive antigen. The immunoblots showed that whereas @entity2 amounts were unaffected by the lesion, ALZ-50 expression was significantly upregulated in the ipsilateral PSN 2 h and 2 days postlesion. The density of @entity2 - and ALZ-50-immunoreactive neurons was significantly higher in the ventral ipsilateral PSN (i.e., the target of the transected infraorbital nerve) than in the contralateral PSN. @entity3 expression selectively and transiently rose in the ventral ipsilateral PSN within 2 h of the lesion. Thus, both @entity2 and the ALZ-50-positive antigen are involved in @entity1 . In light of data suggesting that ALZ-50 recognizes a phosphorylated form of @entity2 , we conclude that @entity1 in the developing nervous system involves the post-translational modification of an existing protein, @entity2 . The increase in ALZ-50 expression apparently occurs during a catabolic phase of @entity1 , as indicated by the increase in @entity3 expression.

title: Neonatal transection of the infraorbital nerve increases the expression of proteins related to XXXX in the principal sensory nucleus of the trigeminal nerve.

answer: @entity1


abstract: UNASSIGNED: The aim of this work was to determine the impact of surgically implanted telemetry transmitters (TTs) on the growth, survival, hematological and biochemical indexes, and wound healing in juvenile pikeperch ( @entity4 ) (body weight 60-90  g). Two incision suturing methods were used-silk sutures (experiment I-group ST) or tissue adhesive (experiment II-group GT). After tagging, the fish were held in a recirculating system for 35  days. No statistically significant differences were noted in the growth or condition indexes analyzed among the fish tagged with TT compared with those from the control groups (untagged). Substantial individual variability was noted, however, in the parameters examined in both the control and tagged groups. Among the hematological indexes, statistically significant differences were only noted in experiment I. Lower values of mean corpuscular volume and mean corpuscular hemoglobin were noted in group ST. Among the biochemical parameters, @entity0 was statistically significantly threefold lower, @entity1 and @entity3 ( @entity3 ) levels were lower, and @entity2 levels were higher in group ST than in the control group. In experiment II, significant differences were only noted for @entity3 . Tissue adhesive was the superior and more effective method for closing the incision after TT implantation in juvenile pikeperch. This type of suturing facilitated faster healing, and it had less of an impact on juvenile pikeperch welfare.

title: The effects of surgically implanted dummy tags on the survival, growth performance, and physiology of pikeperch ( XXXX ).

answer: @entity4


abstract: BACKGROUND: Previous studies have shown an association between the rates of suicide employing certain types of medications and the availability of those drugs. During recent years, prescription patterns of psychoactive drugs commonly used in suicides have undergone some major changes. This study examines whether altered prescription patterns are associated with changes in the rates of drug-related suicides in the elderly. METHODS: An ecological study was performed, in which rates of suicide by @entity3 were related to prescription sales of different psychotropic drugs, derived from the National Prescription Survey (1987-1996). RESULTS: @entity2 were the dominant drug type used by elderly @entity0 who committed suicide by @entity3 . Rates of suicide using @entity2 increased despite decreasing prescription sales. Decreasing tricyclic antidepressant sales and increasing SSRI (selective @entity1 reuptake inhibitors) sales were paralleled by decreasing rates of suicides employing antidepressants. The fatality ratio (FR) decreased for the antidepressant group, increased for @entity2 and remained more or less unchanged for analgesics among the elderly during the study period. CONCLUSIONS: Rates of suicide using @entity2 increased in the elderly despite decreasing prescription sales. @entity2 should be prescribed restrictively to this age group.

title: Suicides by XXXX among the elderly in Sweden 1969-1996.

answer: @entity3


abstract: INTRODUCTION: @entity4 characterized by @entity2 and @entity6 . The presence of @entity7 along with @entity3 during @entity5 in @entity0 with @entity4 has not been described previously. METHODS AND RESULTS: Two female @entity0 (18 and 16 years old) with recurrent @entity7 at the time of @entity5 are described. @entity0 1 had recurrent episodes of @entity5 . During one of these episodes, which occurred while she was being monitored, @entity7 along with high-grade @entity3 was seen at the time of @entity5 and @entity2 . @entity0 2 had a history of recurrent @entity5 and @entity1 . During one of these episodes, she was documented to have ventricular asystole lasting for about 39 seconds. The sinus rate was 480 msec at the beginning, before slowing down to 960 msec prior to restoration of sinus rhythm with 1:1 AV conduction. The same scenario was repeated during head-up tilt testing. Both @entity0 were treated successfully with oral @entity8 and, during a follow-up of 28 months and 9 months, have remained symptom-free. CONCLUSION: Sinus acceleration along with high-grade @entity3 during @entity5 and @entity2 can occur in some @entity0 with @entity4 . The exact mechanism of this phenomenon is unclear.

title: @entity7 with @entity3 : an unusual presentation during XXXX .

answer: @entity4


abstract: BACKGROUND: While family history provides important information on risk of developing @entity1 ( @entity1 ), genetic profiling of first degree relatives (FDR) of @entity2 ( @entity2 ) - affected individuals might provide additional information. We aimed to delineate the genetic contribution to the increased @entity1 susceptibility observed in FDR. METHODS: N=976 Caucasian, healthy, non-related FDR; n=4997 independent @entity2 and n=5000 @entity0 ( @entity0 ); were studied. Genotyping for 158 @entity1 -associated single nucleotide polymorphisms (SNPs) was performed using the Illumina Immunochip. Risk allele frequency (RAF) differences between FDR and @entity0 cohorts were correlated with those between @entity2 and @entity0 cohorts. @entity2 and @entity1 genetic risk scores (GRS) were calculated and compared between @entity0 , FDR and @entity2 cohorts. RESULTS: @entity1 -associated SNP RAF differences in FDR and @entity0 cohorts were strongly correlated with those in @entity2 and @entity0 cohorts, correlation coefficient 0.63 [95%CI 0.53 - 0.72], p = 9.90 x 10(-19). There was a significant @entity3 (mean) comparing @entity0 , FDR and @entity2 cohorts: 0.0244, 0.0250 and 0.0257 respectively (p < 1 x 10(-7) for each comparison). There was no significant difference in the @entity1 -GRS between @entity0 and FDR cohorts (p=0.81); however @entity1 -GRS was significantly higher in @entity2 compared with FDR and @entity0 cohorts (p < 10(-10) for each comparison). CONCLUSION: FDR of @entity2 -affected individuals are enriched with @entity1 risk alleles compared with @entity0 . Cumulative @entity2 -specific genetic risk is increased in FDR compared with @entity0 . Prospective studies are required to determine if genotyping would facilitate better risk stratification of FDR.

title: @entity1 Genetic Risk Profile in Healthy First Degree Relatives of XXXX Patients.

answer: @entity2


abstract: SummaryObjective:to compare the efficacy of two @entity5 protocols ( @entity9 versus @entity4 ) associated with @entity6 for the @entity8 or @entity10 in @entity0 . METHODS: randomized clinical trial comparing @entity4 (0.1mg/kg; max 5mg) and @entity9 (2.0mg/kg, max 70mg) associated with @entity6 (0.2mg/kg; max 10mg) in the @entity8 or @entity10 in @entity0 treated at the pediatrics emergency room (October 2010 and September 2011). The groups were compared in terms of the times to perform the procedures, @entity5 , parent satisfaction and orthopedic team. RESULTS: 13 @entity0 were allocated to @entity9 and 12 to @entity4 , without differences in relation to age, weight, gender, @entity1 , and @entity2 scale before the intervention. There was no failure in any of the groups, no differences in time to start the intervention and overall procedure time. The average hospital stay time was similar ( @entity9 = 10.8+5.1h versus @entity4 = 12.3+4.4hs; p=0.447). The median @entity2 (faces @entity2 scale) scores after the procedure was 2 in both groups. @entity7 was noted in 92.3% ( @entity9 ) and 83.3% ( @entity4 ) (p=0.904). Parents said they were very satisfied in relation to the analgesic intervention (84.6% in the @entity9 group and 66.6% in the @entity4 group; p=0.296). The satisfaction of the orthopedist regarding the intervention was 92.3% in the @entity9 group and 75% in the @entity4 group (p=0.222). CONCLUSION: by producing results similar to @entity4 , @entity9 can be considered as an excellent option in @entity2 management and helps in the @entity8 and @entity10 in @entity3 .

title: Comparison of two @entity5 protocols for the treatment of XXXX .

answer: @entity3


abstract: Significant changes in drug-metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and @entity0 , as well as the risk for adverse drug reactions. To gain a better understanding of DME ontogeny, enzyme contents for six key cytochromes P450 were measured in 240 @entity0 liver samples representing ages from 8 weeks gestation to 18 years. Where possible, both quantitative western blotting and activity assays with probe substrates were performed. Although oversimplified, the DME can be grouped into one of three categories. As typified by @entity4 , some enzymes are expressed at their highest level during the first trimester and either remain at high concentrations or decrease during gestation and are silenced or expressed at low levels within 1-2 years after birth. These data cause one to query whether these enzymes have an important endogenous function. Representatives of a second group, @entity3 and @entity1 , are expressed at relatively constant levels throughout gestation. Postnatal increases in @entity1 are observed within the first year, but not for @entity3 . @entity2 , 2E1, and 3A4 are more typical of a third group of enzymes that are not expressed or are expressed at low levels in the fetus with the onset of expression generally in either the second or third trimester. Substantial increases in expression are observed within the first 1-2 years after birth; however, considerable interindividual variability is observed in the immediate postnatal (1-6 months) onset or increase in expression of these enzymes, often resulting in a window of hypervariability.

title: Ontogeny of XXXX hepatic cytochromes P450.

answer: @entity0


abstract: BACKGROUND: The aims of this study were to reveal the strategies and pitfalls of motor-evoked potential ( @entity5 ) monitoring methods during supratentorial @entity2 surgery, and to discuss the drawbacks and advantages of each method by reviewing our experiences. METHODS: Intraoperative @entity5 monitoring was performed in 250 @entity0 . Results from 4 monitoring techniques using combinations of 2 stimulation sites and 2 recording sites were analyzed retrospectively. RESULTS: @entity5 was recorded successfully in 243 @entity0 (97.2%). Direct cortical stimulation (DCS)-spinal recorded @entity5 (sMEP) was used in 134 @entity0 , DCS-muscle recorded @entity5 ( @entity6 ) in 97, transcranial electrical stimulation (TES)-mMEP in 11 and TES-sMEP in 1. TES-mMEP during closure of the skull was used in 21 @entity0 . DCS-mMEP was able to detect waveforms from upper and/or lower limb muscles. Alternatively, DCS-sMEP (direct [D]-wave) could accurately estimate amplitude changes. A novel "early warning sign" indicating @entity1 was found in 21 @entity0 , which started with a transiently increased amplitude of D-wave and then decreased after proximal interruption of major arteries. False-negative findings in @entity5 monitoring in 2 @entity0 were caused by a @entity3 and by a TES-sMEP recording, respectively. CONCLUSIONS: The results of this study suggest that to perform accurate @entity5 monitoring, DCS-mMEP or DCS-sMEP recording should be used as the situation demands, with combined use of TES-mMEP recording during closure of the skull. DCS-sMEP is recommended for accurate analysis of waveforms. We also propose a novel "early warning sign" of @entity4 in the D-wave.

title: Strategies and Pitfalls of Motor-Evoked Potential Monitoring during Supratentorial XXXX Surgery.

answer: @entity2


abstract: BACKGROUND: Suspicion of @entity2 may persist after an initial negative biopsy result, and repeated biopsy is suggested. The authors assessed whether diagnostic follow-up of @entity0 with an initial diagnosis of isolated, @entity3 ( @entity3 ) and a prostate biopsy suspicious for @entity1 (PBSM) is needed. METHODS: The frequency of isolated @entity3 and PBSM was determined in 4057 @entity0 of a population-based screening study who underwent systematic sextant transrectal biopsy. The predictive value for @entity2 of @entity3 and PBSM was determined by performing repeated biopsies at 6-week interval. The additional predictive value for @entity1 within a screened population was assessed by performing repeated biopsies at a 1-year interval in 462 consecutively recruited @entity0 with an initial benign biopsy result. @entity0 were subjected to a second screening at a 4-year interval. The biopsy and radical @entity1 features were determined. RESULTS: Isolated @entity3 and PBSM were diagnosed in 0.8% and 2.6% of biopsied @entity0 , respectively. The detection rates on repeated biopsy were 10.0% (3 of 30 @entity0 ) for isolated @entity3 , 38.7% (36 of 93 @entity0 ) for PBSM, and 11.0% (51 of 462 @entity0 ) for those with initial benign biopsy results. Except for two @entity0 (one with PBSM and one with @entity3 ), all others remained @entity2 at their second screening. Features of the @entity1 that were detected after PBSM were comparable to those that were detected on initial biopsy, whereas the few @entity1 that were diagnosed after @entity3 had highly favorable features. CONCLUSIONS: Compared with @entity0 who have PBSM, @entity0 with isolated @entity3 on initial biopsy are at no greater risk of being diagnosed with @entity2 than if their initial biopsies were assessed as benign only. Moreover, the features of @entity1 that are diagnosed after an evaluation of @entity3 warrant no early, extensive diagnostic follow-up.

title: The predictive value for @entity2 of lesions that raise suspicion of concomitant carcinoma: an evaluation from a randomized, population-based study of screening for XXXX .

answer: @entity2


abstract: In non-transplant @entity0 mild @entity6 is an independent risk factor for @entity3 . The aim of this study was to determine whether @entity6 is associated with graft @entity3 . Fasting total plasma @entity5 was assessed in 18 @entity0 with graft vasculopathy and 18 transplanted @entity0 without graft vasculopathy matched for age, sex and the time since transplant. All were on cyclosporin. Graft vasculopathy was defined at coronary angiography as stenoses > or = 25%, or @entity2 . We found that @entity6 ( > or = 15 micromol/l) is common among transplanted heart recipients and significantly more frequent in the @entity0 with graft vasculopathy (17/18 versus 11/18). Accordingly, the mean @entity7 was significantly higher in the group with graft vasculopathy (23.6+/-7.8 versus 16.9+/-7.1 micromol/l, P=0.01). The elevation of @entity5 plasma levels in the heart transplant recipients has probably multiple causes. The main cause seems to be @entity1 . Additional causes could be @entity4 treatment or genetic polymorphisms. These results suggest that besides the immunological factors, @entity5 can play an additional role in the pathogenesis of graft @entity3 .

title: Association of mild XXXX with cardiac graft vascular disease.

answer: @entity6


abstract: PURPOSE: To report on 5 @entity0 who had @entity7 ( @entity6 ) with hourglass-like constriction in the affected nerves. METHODS: We retrospectively reviewed 5 @entity0 who were treated in our department from December 2003 to December 2008. Acute, intense @entity2 around the shoulder girdle and upper arm was the first symptom and was followed by @entity4 and @entity3 . Clinical and EMG examinations showed involvement of 2 or more nerves in the affected extremity. Those severely affected nerves that had no response to conservative treatment were explored, and an hourglass-like constriction was identified. Neurolysis was performed at the sites of constrictions in 2 radial nerves and 1 median nerve. The constricted portion was resected, and direct coaptation was performed in 1 radial nerve and 1 musculocutaneous nerve. The constricted portion was resected, and nerve graft was performed in 2 radial nerves and 1 median nerve. RESULTS: All @entity0 were followed up for 24 to 84 months after surgery. Of 3 nerves treated with external neurolysis, all attained full recovery. Of 2 nerves treated with resection and neurorrhaphy, 1 attained full recovery, and the other had an incomplete recovery. Of 3 nerves treated with resection and nerve graft, 1 (4-cm nerve graft) attained full recovery, and 2 (4-cm and 13-cm nerve graft, respectively) had incomplete recovery. CONCLUSIONS: The site of @entity1 of @entity6 was not necessarily within the brachial plexus. Our finding of hourglass-like constrictions in individual peripheral nerves suggest that multifocal involvement of terminal branch lesions may underlie the complex patterns of @entity5 often encountered clinically. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV.

title: Typical @entity6 ( XXXX ) with hourglass-like constrictions in the affected nerves.

answer: @entity6


abstract: OBJECTIVE: To evaluate the association of gr/gr deletion in the AZFc region of Y chromosome with @entity4 using Meta-analysis. METHODS: All relevant case-control studies addressing the relationship between gr/gr deletion and @entity4 were identified from PubMed, @entity3 and CNKI (from January 2003 to August 2010). Statistical analyses were performed with the RevMan4. 2 software. RESULTS: Twenty eligible articles were selected in this study, including 5 246 cases of idiopathic @entity2 and 4 380 controls. The integrated data from the 20 studies revealed a significantly higher frequency of gr/gr deletion in the @entity0 than in the controls, with an odds ratio (OR) of 1.63 (95% CI: 1.23 -2.44) (P = 0.002). However, when the Meta-analysis was limited to 16 studies with stricter case and control selection criteria, the overall OR increased to 1.84 (95% CI: 1.47 - 2.29) (P < 0.000 01). Thirteen studies showed that @entity5 @entity0 had a significantly higher frequency of gr/gr deletion than controls (OR = 2.12, 95% CI: 1.61 - 2.80) (P < 0.000 01). Eight studies showed a significant association between the gr/gr deletion subtype without @entity6 / @entity7 gene copies and @entity1 (OR = 1.83, 95% CI: 1.31 - 2.55) (P = 0.000 4), but no statistically significant differences were found in the frequency distribution of the gr/gr deletion subtype missing @entity8 / @entity9 gene copies between the @entity0 and controls (OR = 1.43, 95% CI: 0.97 -2.11) (P = 0.07). CONCLUSION: The present data suggest that gr/gr deletion may be one of the risk factors of @entity4 .

title: [Association of gr/gr deletion in the AZFc region of Y chromosome with XXXX : a meta-analysis].

answer: @entity4


abstract: Intravenous @entity10 was administered to 109 @entity0 (65 female and 44 male) with either pre- or post-operative progressive @entity1 from @entity9 following @entity5 from a @entity7 . In 91 of the @entity0 the efficacy of @entity10 in relieving @entity3 symptoms was assessed and in all of the 109 @entity0 the tolerance was evaluated. The @entity4 were related to following arteries: anterior communicating artery (41%), @entity8 (24%), internal carotid artery (10%), @entity11 (4%) and others (5.5%); 11% of the @entity0 had @entity4 . On 16 of the 91 @entity0 no surgery was performed. On 16% of the remaining 75 @entity0 surgery was performed within 72 hours after the @entity6 , 57% were operated between day 4 and day 15 and 29% after day 16. The @entity2 occurred preoperatively in 67% of the @entity0 and post-operatively in 23%. At the beginning of treatment 84% of the @entity0 were graded III-V according to the Hunt and Hess grading system. Most of the @entity0 received doses of 24-48 mg @entity10 daily as constant i.v. infusion for 7-10 days. The grade of @entity2 at the end of the treatment was evaluated according to the Glasgow Outcome Scale. 59 (65%) of the @entity0 showed complete recovery or marked improvement of the @entity3 symptoms while 22% remained unchanged and 11% died due to severe @entity9 . Administration of @entity10 seemed to be more efficient in cases where treatment was started within 24 hours. In the @entity0 group which was treated pre-operatively, recurrent @entity6 was recorded in 8% of the @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX treatment of @entity2 due to @entity9 after @entity5 . Clinical results of a multicenter study.

answer: @entity10


abstract: PURPOSE: In order to evaluate the feasibility of dose-dense @entity5 followed by dose-dense AC ( @entity3 / @entity4 ) as adjuvant chemotherapy for operable @entity0 , we conducted a phase II study. @entity1 AND METHODS: In cohort 1, 28 @entity1 received @entity5 100 mg/m2 followed by @entity3 60 mg/m2 with @entity4 600 mg/m2, each every 2 weeks for 4 weeks (total of 8 cycles). Enrollment was discontinued because of stopping criteria based on significant @entity2 (grade 4 hematologic @entity2 or grade >or= 3 nonhematologic @entity2 ). In cohort 2, the @entity5 dose was reduced to 75 mg/m2; enrollment was discontinued after 18 @entity1 . RESULTS: Significant @entity2 occurred in 79% and 72% of @entity1 in cohorts 1 and 2, respectively, resulting in treatment delays in 50% and 17% of @entity1 , respectively. The most common grade 4 hematologic @entity2 was @entity6 , which occurred in 7% and 42% of cohort 1 @entity1 during @entity5 and AC, respectively, and in none and 19% of cohort 2 @entity1 , respectively. The most common grade >or= 3 nonhematologic @entity2 was @entity7 , which occurred in 25% and none of cohort 1 @entity1 during @entity5 and AC, respectively. With @entity5 75 mg/m2 and @entity1 education encouraging routine use of topical strategies, grade 3 @entity7 occurred in only 11% of cohort 2 @entity1 . Grade 2 nail changes were also debilitating and occurred in 33% of cohort 1 @entity1 during AC. CONCLUSION: These phase II findings suggest that dose-dense @entity5 100 mg/m2 followed by AC is not feasible and, until more studies are conducted, should be restricted to clinical studies.

title: XXXX of dose-dense @entity5 followed by @entity3 with @entity4 as adjuvant therapy for @entity0 in a phase II study.

answer: @entity2


abstract: OBJECTIVE: To investigate the communication between @entity1 and subarachnoid space using CT cisternography (CTC) and consecutive CT scans. METHODS: CTC were performed in 38 symptomatic @entity0 with @entity1 before treatment decisions were made. Consecutive CTC images were obtained 2 days after intrathecal omnipaque administrations. The enhancement in cysts was measured quantitatively and compared with neighbouring subarachnoid spaces. @entity0 with cysts showing @entity2 (n = 10) were followed up without surgeries. Whereas, @entity0 with cysts showing non- @entity2 (n = 28) were given surgical treatment through craniotomy. Another 36 @entity0 with @entity1 were given craniotomy without CTC evaluation. RESULTS: @entity1 were classified into complete, incomplete and noncommunicating cysts based on the CTC results. The symptoms of all surgical @entity0 with CTC evaluations were relieved. Only one @entity0 without surgery showed clinical deterioration. In the 36 @entity0 without CTC evaluation, 6 @entity0 did not gain benefit from surgeries. CONCLUSION: The classification of @entity1 based on CTC is useful for the diagnosis and treatment of @entity1 .

title: [Dynamic CT cisternography in the diagnosis and treatment of XXXX ].

answer: @entity1


abstract: @entity3 ( @entity3 ) is the principal cytokine regulating granulopoiesis. @entity3 receptor-deficient @entity0 ( @entity2 -/-) are neutropenic but have only a modest reduction of committed myeloid progenitors. Since it is likely that compensatory mechanisms are induced by the severe @entity1 present in @entity2 -/- @entity0 , a competitive repopulation assay was performed. These data show that under basal conditions, @entity3 drives nearly all of granulopoiesis through multiple mechanisms. Most importantly, @entity2 signals regulate the production and/or maintenance of committed-myeloid progenitors. Surprisingly, @entity2 signals also play a significant role in the regulation of primitive multipotential progenitors in vivo. The contribution of @entity2 -/- cells to the hematopoietic stem cell compartment is modestly reduced. Moreover, a marked decrease in the contribution of @entity2 -/- cells to other progenitors in the myeloid pathway, including erythroid and megakaryocytic progenitors, is observed. In contrast, relative to the hematopoietic stem cell compartment, the contribution of @entity2 -/- cells to the lymphoid lineages is increased. These data suggest that @entity2 signals may play a role in directing the commitment of primitive hematopoietic progenitors to the common myeloid lineage. Thus, regulation of @entity3 levels may provide a mechanism for directing primitive hematopoietic progenitors into the common myeloid lineage in response to environmental stresses.

title: Pivotal role of XXXX in the development of progenitors in the common myeloid pathway.

answer: @entity3


abstract: INTRODUCTION: Perineal wound complications are a main problem after abdominoperineal resection (APR). There is little evidence concerning perineal wound management. This study describes and evaluates the role of vacuum-assisted closure (VAC) therapy in wound management strategies of perineal wound infections after APR. METHODS: @entity0 undergoing APR for @entity1 between January 2007 and January 2013 were identified retrospectively. Data regarding occurrence and management of perineal wound complications were collected. Perineal wound infections were classified into minor or major complications and time to wound healing was measured. Time to wound healing was compared between @entity0 receiving routine care or with additional VAC therapy. RESULTS: Of 171 included @entity0 , 76 (44.4%) had minor and 36 (21.1%) major perineal wound infections. Management of major @entity3 consisted of drainage (n  =  16), debridement (n  =  4), drainage combined with debridement (n  =  4), VAC therapy alone (n  =  5), or VAC therapy combined with other treatments (n  =  7). Median duration of perineal wound healing in @entity2 wounds was 141 days (range 17-739). Median time to wound healing was not different in @entity0 treated with (172 days, range 23-368) or without VAC therapy (131 days, range 17-739). DISCUSSION AND CONCLUSION: In this study, VAC therapy did not shorten time to wound healing. However, prospective studies are required to investigate the role of VAC therapy in management of @entity3 after APR. Up to then, wound management will remain to be based on clinical perception and 'gut-feeling'.

title: Vacuum-assisted closure therapy for XXXX after abdominoperineal resection. A retrospective cohort study.

answer: @entity3


abstract: Parasites are typically aggregated within their host populations. The most heavily infected hosts are frequently cited as targets for optimal disease control. Yet a heavily infected individual is not necessarily highly infective and does not automatically contribute a higher proportion of infective parasitic stages than a host with fewer @entity2 . Here, Pseudamphistomum truncatum (Opisthorchiida) parasitic @entity1 within the definitive otter host ( @entity3 ) is used as a model system. The hypothesis tested is that variation in parasite abundance, aggregation and egg production (fecundity, as a proxy of host infectivity) can be explained by abiotic (season and region) or biotic (host age, sex and body condition) factors. Parasite abundance was affected most strongly by the biotic factors of age and body condition, such that adults and otters with a higher condition index had heavier infections than sub-adults or those with a lower condition index, whilst there were no significant differences in parasite abundance among the seasons, regions (ecological regions defined by river catchment boundaries) or host sexes. Conversely, parasite aggregation was affected most strongly by the abiotic factors of season and region, which were supported by four different measures of parasite aggregation (the corrected moment estimate k, Taylor's Power Law, the Index of Discrepancy D, and Boulinier's J). Pseudamphistomum truncatum was highly aggregated within otters, with aggregation stronger in the Midlands (England) and Wales than in the southwestern region of the United Kingdom. Overall, more @entity2 were found in fewer hosts during the summer, which coincides with the summer peak in parasite fecundity. Combined, these data suggest that (i) few otters carry the majority of P. truncatum @entity2 and that there are more infective stages (eggs) produced during summer; and (ii) abiotic factors are most influential when describing parasite aggregation whilst biotic factors have a greater role in defining parasite abundance. Together, parasite abundance, aggregation and fecundity can help predict which hosts make the largest contribution to the spread of @entity0 .

title: Spatial and seasonal factors are key determinants in the aggregation of helminths in their definitive hosts: Pseudamphistomum truncatum in otters ( XXXX ).

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) is the leading cause of maternal mortality worldwide and accounts for one third of maternal deaths in low-income and middle-income countries. @entity2 can be prevented by active management of the third stage of labor (AMTSL), a series of steps recommended by the World Health Organization to be performed by skilled birth attendants (SBAs). Task shifting in the AMTSL step of uterotonic drugs administration to community health workers, traditional birth attendants and self-administration has been investigated as a strategy to increase access to quality obstetric care considering persistent SBA and facility-based delivery shortages. The aim of this study is to assess task shifting in the final step of AMTSL and compare uterine tonus assessment by a SBA to self-assessment. METHODS AND DESIGN: The study is an individual-level two-arm non-inferiority randomized controlled trial (RCT). A total of 800 @entity0 will be recruited in Korle Bu Teaching Hospital in Accra, Ghana. Adult @entity0 in labor at term with an expected vaginal delivery who received antenatal instructions for self-assessment of uterine tonus will be eligible for inclusion. @entity0 with an increased risk for @entity2 will be excluded. @entity0 will be randomized to uterine tone assessment by a skilled birth attendant (midwife) or uterine tone self-assessment (with the safety back-up of a midwife present in case of @entity2 or uterine atony). Postpartum @entity1 will be measured through weighing of disposable mats. The main study endpoints are @entity2 (>= 500  ml @entity1 ), severe @entity2 (>= 1000  ml @entity1 ), mean @entity1 , and routine maternal and neonatal outcomes. @entity0 and caregivers will not be blinded given the nature of the intervention. DISCUSSION: A reduction of @entity2 -related maternal mortality requires full implementation of AMTSL. Task shifting of uterine tone assessment may contribute to increased AMTSL implementation in (clinical) settings where SBAs capacity is constrained. TRIAL REGISTRATION: Clinicaltrials.gov: NCT02223806 , registration August 2014. PACTR: PACTR201402000736158 , registration July 2014. University of Ghana, Medical School Ethical and Protocol Review Committee: MS-Et/M.8-P4.1/2014-2015.

title: Uterine Tonus Assessment by Midwives versus XXXX self-assessment in the active management of the third stage of labor (UTAMP): study protocol for a randomized controlled trial.

answer: @entity0


abstract: UNASSIGNED: @entity9 ( @entity4 ) is an extremely uncommon @entity6 that resembles @entity2 ( @entity2 ). We report a case of incidentally detected pancreatic @entity4 combined with a serous microcystic @entity10 , in a 47-year-old @entity0 , while he was being evaluated for @entity8 . Contrast enhanced computed tomography (CECT) of abdomen revealed a lesion with mild heterogeneous enhancement in the tail of @entity6 and another proximal lesion having moderate enhancement, and a @entity7 . Serum chromogranin, carcinoembryonic antigen (CEA) and CA 19-9 levels were within normal limits. He underwent laparoscopic distal pancreatectomy with splenectomy and cholecystectomy. Pathologically the distal @entity1 was encapsulated and characterized by eosinophilic cytoplasm, vesicular nucleus with prominent nucleolus and intranuclear eosinophilic inclusions. The cells were arranged in trabecular pattern separated by sinusoids. Canalicular and intercellular bile plugs were seen. On @entity1 cells were positive for hepatocyte specific antigen and weakly positive for @entity3 ( @entity3 ). The proximal @entity1 showed features of @entity5 . Based on these findings, the case was diagnosed as @entity1 combined with serous microcystic @entity10 . Post operative @entity3 was 1.75 IU/mL. The @entity0 is on follow up for the last eight months and there is no evidence of recurrence.

title: @entity4 of the XXXX combined with serous @entity10 : a case report and review of the literature.

answer: @entity6


abstract: Activation of members of the mitogen-activated protein (MAP) kinase family and their downstream effectors has been proposed to play a key role in the pathogenesis of cell survival, ischaemic preconditioning, @entity4 and @entity1 . This study investigated the responses of @entity6 kinase and multiple MAP kinases during the transition from compensated pressure-overload @entity3 to decompensated @entity1 . Extracellular signal-regulated protein kinase (ERK) 1/2, p38, and @entity6 were activated by chronic pressure-overload and their activity was sustained for 8 weeks after aortic banding. In contrast, while p90 ribosomal S6 kinase (90RSK) and big MAP kinase 1 (BMK1) were activated in compensated @entity3 , their activities were significantly decreased in hearts with @entity1 . No changes were found in C-Jun @entity5 terminal kinase (JNK) activity after aortic banding. These data suggest that differential activation of MAP kinase family members may contribute to the transition from compensated to decompensated @entity3 . We also examined acute effects of mechanical stretch on the activation of these kinases in normal and @entity3 hearts. In the isolated coronary-perfused heart, a balloon in the left ventricle was inflated to achieve minimum end-diastolic pressure of 25 mmHg for 10-20 min. In normal @entity2 hearts, stretch activated ERK1/2, p90RSK, p38, @entity6 , and BMK1 but not JNK. However in @entity3 hearts, further activation of these kinases was not observed by acute mechanical stretch. Mechanical stretch-induced activation of ERK1/2 and p38 kinase in normal hearts was attenuated significantly by a protein kinase C inhibitor, @entity0 . We demonstrate that ERK1/2, p90RSK, p38, @entity6 , and BMK1 are activated by chronic pressure-overload and by acute mechanical stretch. These data suggest that @entity6 , BMK1 and p90RSK play a role as novel signal transduction pathways leading to @entity4 . In addition, the differential inhibition of p90RSK and BMK1 in hearts with @entity1 suggests the specific role of these two kinases to maintain cardiac function under chronic pressure-overload.

title: @entity6 and multiple MAP kinase activation in XXXX and @entity1 under chronic pressure-overload: comparison with acute mechanical stretch.

answer: @entity4


abstract: The efficacy of both preliminary and continuous hemodialysis during extracorporeal circulation (ECC) was evaluated in the pediatric population. Preliminary hemodialysis of the priming solution was initiated in eight @entity0 ( @entity1 -I group), while both preliminary and continuous hemodialysis during ECC was performed in another eight @entity0 ( @entity1 -II group). The control group which consisted of eight @entity0 did not undergo hemodialysis. Urine volume during ECC, perfusion pressure, and water balance were measured and compared among the three groups. In the @entity1 , the total urine volume during ECC was greater than in control group, but there was no significant difference. In the control group, the perfusion pressure temporally decreased after the pump was operating for five minutes, but the perfusion pressures remained stable in the @entity1 . Therefore, preliminary hemodialysis appears to prevent the "initial drop" seen in perfusion pressures. Water balance in the control group tended to be in positive balance, but both the @entity1 appeared to be in negative balance. Significant differences between @entity1 -I and @entity1 -II in contrast to the control group (p < 0.05) and p < 0.04, respectively) were observed. Preliminary hemodialysis is useful during ECC in @entity0 and @entity0 because by maintaining perfusion pressure urine output remains adequate while a net negative water balance is achieved. Preliminary hemodialysis will increase the continuous hemodialysis in @entity0 who are subjected to prolonged extracorporeal circulation.

title: [Role for preliminary and continuous hemodialysis during extracorporeal circulation in XXXX and @entity0 ].

answer: @entity0


abstract: OBJECTIVE: We aim to expose our experience in the surgical correction of stress @entity5 (SUI) and to analyze the possible factors that could modify the outputs of this type of surgery. METHODS: We have studied 114 @entity0 who underwent surgery (60 Raz, 36 Burch, and 18 vaginal wall sling), with a mean follow-up time of 10.5 months. RESULTS: We have not succeeded in demonstrating that preoperative factors such as age, irritative voiding symptoms; history of prior hysterectomy or urethropexia, @entity2 , @entity1 or recurrent @entity4 ; the finding of cistocele, a positive Bonney-Marchetti test or bladder unstability, play any role in the outputs. The failure rate was 16.7% for vaginal wall sling procedure, 35% Raz, and 33.3% Burch. "Survival" analysis did not demonstrate differences related to the procedure or the surgeon. We discovered and important decrease of continence rate with time from the intervention. Higher incidence of @entity3 , urinary retention and greater residual urine were detected with transvaginal procedures. There was no difference in the incidence of @entity6 . CONCLUSIONS: We don't believe that the selection of candidates for this type of surgery should be carried out in base to the above mentioned preoperative factors. Also, we observed a consistent decrease of postoperative continence with time. Finally, we have detected a greater incidence of complications after transvaginal procedures.

title: [Comparative analysis of various techniques for the repair of stress XXXX in @entity0 . Review of our experience].

answer: @entity5


abstract: BACKGROUND: @entity4 incidence is increasing and is associated with a high rate of mortality. Although lipid-based formulations of @entity3 are the recommended first-line treatment, only one prospective trial in a limited number of @entity0 has been performed to evaluate this regimen. METHODS: @entity0 with proven or probable @entity4 were included between June 2007 and March 2011. @entity0 were scheduled to receive 10 mg/kg/day liposomal @entity3 (L-AMB) monotherapy for 1 month and surgery was performed when appropriate. The primary outcome was response rate at week 4 or at the end of treatment (EOT) if before week 4, evaluated by an independent committee. ClinicalTrials.gov Identifier: NCT00467883. RESULTS: Forty @entity0 were enrolled. Response was analysed in 33 @entity0 at week 4. Most @entity0 had a @entity1 as their primary underlying disease (53%). Seventy-one percent of @entity0 underwent therapeutic surgery. The response rate at week 4 or at EOT was 36%, with 18% partial responses and 18% complete responses. The response rate at week 12 was 45%, with 13% partial responses and 32% complete responses. Overall mortality was 38% at week 12 and 53% at week 24. Serum @entity2 doubled in 16 (40%) @entity0 and returned to normal levels within 12 weeks in 10/16 (63%). CONCLUSIONS: High-dose L-AMB for @entity4 , in combination with surgery in 71% of cases, was associated with an overall response rate of 36% at week 4 and 45% at week 12 and @entity2 level doubling in 40% of @entity0 (transient in 63%). These results may serve as the basis for future clinical trials.

title: Prospective pilot study of high-dose (10 mg/kg/day) liposomal XXXX (L-AMB) for the initial treatment of @entity4 .

answer: @entity3


abstract: BACKGROUND: A phase II randomised discontinuation trial assessed @entity11 ( @entity11 ), an orally bioavailable inhibitor of @entity9 kinases including VEGF receptors, MET, and @entity10 , in a cohort of @entity0 with @entity5 . METHODS: @entity0 received @entity11 100   mg daily during a 12-week lead-in. @entity0 with @entity1 ( @entity1 ) per Response Evaluation Criteria in Solid Tumours (RECIST) at week 12 were randomised to @entity11 or placebo. Primary endpoints were objective response rate (ORR) at week 12 and postrandomisation progression-free survival (PFS). RESULTS: Seventy-seven @entity0 were enroled (62% cutaneous, 30% uveal, and 8% mucosal). At week 12, the ORR was 5%; 39% of @entity0 had @entity1 . During the lead-in phase, reduction in target lesions from baseline was seen in 55% of evaluable @entity0 overall and in 59% of evaluable @entity0 with @entity8 . Median PFS after randomisation was 4.1 months with @entity11 and 2.8 months with placebo (hazard ratio of 0.59; P=0.284). Median PFS from study day 1 was 3.8 months, 6-month PFS was 33%, and median overall survival was 9.4 months. The most common grade 3/4 adverse events were @entity7 (14%), @entity2 (10%), and @entity6 (8%). One treatment-related @entity3 was reported from @entity4 due to diverticular perforation. CONCLUSIONS: @entity11 has clinical activity in @entity0 with @entity5 , including @entity8 . Further clinical investigation is warranted.

title: Phase II randomised discontinuation trial of the MET/VEGF receptor inhibitor XXXX in @entity5 .

answer: @entity11