abstract: UNASSIGNED: @entity0 norovirus (HuNoV) is the leading cause of @entity3 with an increasing number of outbreaks associated with leafy greens. Because HuNoV cannot be routinely cultured, culturable @entity4 ), @entity1 norovirus (MNV), porcine sapovirus (SaV) and Tulane virus (TV) have been used as surrogates. These viruses are generated in different cell lines as infected cell lysates which may differentially affect their stability. Our objective was to uniformly compare the survival of these viruses on postharvest lettuce, while evaluating the effect of cell lysates on their survival. Viruses were semi-purified from cell lysates by ultrafiltration or ultracentrifugation followed by re-suspension in sterile water. Virus survival was examined before and after semi-purifications: in suspension at @entity2 ( @entity2 ) until day 28 and on lettuce leaves stored at @entity2 for 3 days, or 4   C for 7 and 14 days. In suspension, both methods significantly enhanced the survival of all viruses. On lettuce, the survival of MNV in cell lysates was similar to that in water, under all storage conditions. In contrast, the survival of @entity4 , SaV and TV was differentially enhanced, under different storage conditions, by removing cell lysates. Following semi-purification viruses showed similar persistence to each other on lettuce stored under all conditions, with the exception of ultracentrifugation-purified @entity4 which showed higher inactivation rate than MNV at 4    C for 14 days. In conclusion, the presence of cell lysates in viral suspensions underestimated the survivability of these surrogate viruses while viral semi-purifications revealed a similar survivability on postharvest lettuce leaves.

title: XXXX , @entity1 Norovirus, Porcine Sapovirus and Tulane Virus Survival on Postharvest Lettuce.

answer: @entity4


abstract: Background. @entity2 ( @entity2 ) is an important nonmotor manifestation of @entity1 ( @entity1 ). Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler. Objective. To identify possible changes in cerebrovascular reactivity in @entity0 with @entity2 . Methods. Twenty-two individuals were selected and divided into three groups: with and without @entity2 and controls. Transcranial Doppler was used to assess basal mean blood flow velocity, postapnea mean blood flow velocity, percentage increase in mean blood flow velocity, and cerebrovascular reactivity as measured by the breath-holding index. Results. @entity1 @entity0 had lower values of basal velocity (p = 0.019), postapnea velocity (p = 0.0015), percentage increase in velocity (p = 0.039), and breath-holding index (p = 0.04) than the controls. @entity0 with @entity2 had higher values of basal velocity (p = 0.09) and postapnea velocity (p = 0.19) but lower values of percentage increase in velocity (p = 0.22) and breath-holding index (p = 0.32) than @entity0 without @entity2 . Conclusions. @entity1 @entity0 present with abnormalities in a compensatory mechanism that regulates cerebral blood flow. @entity2 could be an indicator of these abnormalities.

title: Abnormal Cerebrovascular Reactivity in @entity0 with XXXX .

answer: @entity1


abstract: UNASSIGNED: The serotonergic system plays a crucial role in the energy balance regulation. Energy balance is mediated by food intake and caloric expenditure. Thus, the present study investigated the mechanisms that might be associated with @entity3 treatment-induced @entity1 . @entity0 male @entity0 pups received daily injections with subcutaneous @entity3 (Fx-group) or vehicle solution (Ct-group) from day 1 until 21  days of age. Several analyses were conducted to verify the involvement of mitochondria in @entity1 . We found that body weight in the Fx-group was lower compared to control. In association to lower fat mass in the Fx-group (25  %). Neither neonatal caloric intake nor food intake reveals significant differences. Evaluating caloric expenditure (locomotor activity and temperature after stimulus), we did not observe differences in locomotor activity. However, we observed that the Fx group had a higher capacity to maintain body temperature in a cold environment compared with the Ct-group. Since brown adipose tissue-(BAT) is specialized for heat production and the rate of heat production is related to mitochondrial function, we found that Fx-treatment increases respiration by 36  %, although after addition of @entity4 respiration returned to Ct-levels. Examining ROS production we observe that Fx-group produced less ROS than control group. Evaluating uncoupling protein (UCP) expression we found that Fx-treatment increases the expression by 23  %. Taken together, our results suggest that modulation of @entity2 system results in positive modulation of UCP and mitochondrial bioenergetics in brown fat tissue.

title: XXXX induces lean phenotype in @entity0 by increasing the brown/white adipose tissue ratio and UCP1 expression.

answer: @entity3


abstract: Selective posterior rhizotomy is effective for relieving @entity2 associated with @entity1 . In current techniques dorsal roots from @entity5 to S1/S2 are selectively divided. With transoperative electromyography (EMG) significant sensory loss has been prevented, but postoperative @entity4 following excessive reduction of the fusimotor drive is still of concern for surgeons and therapists. To decrease the volume of deafferentiated rootlets we proposed a limited selective posterior rhizotomy (LPSR) that limits the extent of the surgery to three (L4-S1) or two (L5-S1) dorsal roots. We present the results of two group of @entity2 @entity0 ; group 1 (n = 59, 32 quadriplegic and 27 diplegic) who had a L4-S1 LPSR, and group 2 (n = 12) in whom L5 and S1 were selectively rhizotomized. Posture, passive movilization, range of joint movement, and muscle tone in hip flexors, adductors, @entity3 were graded according to the method proposed by Sindou and Jeanmonod. In all groups these was a significant reduction of the mentioned parameters (Friedman test p < 0.001) at 6, 12 and 18 months after surgery. The preoperative and postoperative ability to ambulate was classified into five grades. In all groups there was a significant (chi 2 between p < 0.01 and p < 0.001) improvement in the quality of their gait. A third of the @entity0 achieved some form of independent ambulation. Our results suggest that extensive selective deafferentation of the lower limbs is not an absolute requisite for reducing muscle tone or achieving functional improvement in @entity2 @entity0 .

title: Limited (L4-S1, L5-S1) selective dorsal rhizotomy for reducing XXXX in @entity1 .

answer: @entity2


abstract: The @entity0 was a 51-year-old @entity0 who had been prescribed @entity10 for right third-branch trigeminal @entity2 . He had stopped taking the medication after the @entity2 resolved. When the @entity2 recurred, he resumed medication, and about 1 month later he developed @entity5 , @entity9 , cervical @entity11 , generalized skin flushing, @entity1 and @entity13 , and was admitted to Ichikawa General Hospital, Tokyo Dental College. Oral findings showed @entity12 . Routine laboratory examination revealed @entity7 and @entity6 . Human herpesvirus 6 antibody titer remarkably increased during development of @entity4 . These findings led to a diagnosis of @entity3 . @entity10 was discontinued, and @entity8 (30 mg/day) was started and tapered based on improvement of symptoms. Because skin symptoms recurred after he was discharged 15 days after admission, the dose of @entity8 was increased and the symptoms finally disappeared. The @entity0 has experienced no further recurrence.

title: A case of @entity3 due to XXXX .

answer: @entity10


abstract: BACKGROUND: The subject of post-conflict mental health lacks studies that are nationally representative or large enough to allow robust examination of levels of distress according to residency in geographical zones of conflict and ethnic minority status. We undertook a nationwide study in @entity5 Lanka to address these issues. METHODS: We used tablet devices to survey 20   632 @entity0 across 18 of 25 districts in @entity5 Lanka, of which nine were purposefully selected and nine randomly selected districts. Based on their exposure to war and levels of population displacement, these districts were classified as being in the severe, moderate, or minimal conflict zones. Trained local fieldworkers did private interviews with the @entity0 in the local language; responses were entered directly into the tablet devices. The questions assessed exposure to a wide range of stresses, including ongoing adversities, threat or protection issues, and service access factors, and respondents provided categorical responses (yes/no) to a list of items. We used the 25-item Hopkins Symptom Checklist to measure @entity2 and @entity1 in @entity0 . We used multivariate analysis and calculated population-attributable fractions to estimate potential improvement in mental distress if modifiable factors were addressed. FINDINGS: Our results showed a stepwise increase in symptoms of @entity2 (10%, 33%, 40%) and @entity1 (13%, 23%, 23%) across minimal, moderate, and severe conflict zones, respectively. Membership of an ethnic minority group was associated with @entity2 (Tamil odds ratio [OR] 2  4 [95% CI 1  8-3  1], other ethnic minority OR 2  7 [2  1-3  6]) and @entity1 (Tamil OR 1  5 [1  1-2  0], other ethnic minority OR 1  5 [1  2-1  8]). Other fixed characteristics associated with @entity2 and @entity1 were older age (both @entity2 and @entity1 ; OR 2  7 [95% CI 2  0-3  7] for @entity1 and 2  3 [1  7-3  0] for @entity2 ), being married ( @entity1 only; OR 1  5 [95% CI 1  1-2  1]), and time spent in camps for internally displaced @entity0 ( @entity1 only; @entity8 [95% CI 1  0-1  9]). Modifiable characteristics were threat or protection issues ( @entity2 @entity9 [95% CI 1  2-2  8], @entity1 @entity9 [1  3-2  6]) and scarcity of food ( @entity2 @entity8 [1  2-1  6], @entity1 @entity8 [1  2-2  7]), loss of job (OR 1  2 [95% CI 1  2-1  4] for @entity1 ), and proximity to army camps ( @entity7 [95% CI 1  2-2  2] for @entity2 ). Allaying of safety concerns had the potential to reduce @entity2 by 53% and @entity1 by 57%, with other factors (removal of army camps from proximity and addressing @entity6 , @entity3 and threat/protection issues) making smaller contributions to a reduction in @entity2 and @entity1 . INTERPRETATION: Our findings offer a basis for detecting high-risk groups and provide directions in devising policies and programmes aimed at alleviating @entity4 in @entity5 Lanka. Restoration of safety seems to be crucial to mental health recovery. FUNDING: Australian National University-Department of Immigration Border Protection Collaborative Research Program.

title: Associations of mental distress with residency in conflict zones, ethnic minority status, and potentially modifiable social factors following conflict in XXXX Lanka: a nationwide cross-sectional study.

answer: @entity5


abstract: UNASSIGNED: The treatment of lymph node @entity1 involving the carotid artery is controversial. The aim of the present study was to determine the outcomes of @entity2 @entity0 with radiographic carotid artery involvement in neck @entity1 . A total of 27 @entity0 with @entity2 and radiologically diagnosed advanced @entity1 involving the common carotid artery or internal carotid artery were enrolled. All @entity0 underwent a primary or salvage neck dissection and surgical carotid peeling. The oncological outcome and survival of all @entity0 were analyzed. Loco-regional control was observed in 13 of the 27 @entity0 (48.1%). During follow-up, five @entity0 (18.5%) developed second primaries and 11 (40.7%) developed distant @entity1 . The survival time was poor independent of regional control. The median overall survival was 1.55 years and disease-free survival was 0.71 year. Radiographic carotid artery involvement in neck @entity1 in @entity2 appears to correlate with a poor long-term prognosis, with a high rate of distant @entity1 despite loco-regional control.

title: Clinical impact of radiographic carotid artery involvement in neck @entity1 from XXXX .

answer: @entity2


abstract: PURPOSE: To quantify the dynamics of capsular bag shrinkage after @entity1 surgery. SETTING: University Eye Hospital, Vienna, Austria. METHODS: Nineteen eyes in 13 @entity0 had clear corneal @entity1 surgery with implantation of a foldable, open-loop, @entity2 posterior chamber intraocular lens (IOL) (AMO SI-30). At the same time, an open, @entity4 capsule tension ring (Morcher type 14 or 14A) was inserted to allow measurement of capsular bag circumference and diameter. After surgery, capsular bag shrinkage was quantified by measuring @entity5 ( @entity5 ), @entity3 ( @entity3 ), and distance between the eyelets of the capsule tension ring using optical methods. Capsular bag circumference (CBC) was deduced from these measurements, which were taken 1 day (baseline), 1 week, and 1 and 3 months postoperatively. RESULTS: Between 1 day and 3 months, all three parameters decreased significantly. During the first postoperative week, @entity5 and @entity3 did not change, while both parameters decreased between 1 week and 1 month. After 1 month, @entity5 did not decrease further; @entity3 continued to decrease. The CBC decreased during the entire postoperative period. CONCLUSION: Besides @entity5 and @entity3 , CBC significantly decreased during the first 3 months after @entity1 surgery with in-the-bag posterior chamber IOL implantation. The CBC can be calculated from the distance between the ends of the capsule tension ring, which can be measured gonioscopically. From this, the diameter of the capsular bag can be calculated in the living eye. The influence of the capsule tension ring itself on capsular bag shrinkage remains to be established.

title: Capsular bag shrinkage after implantation of an open-loop @entity2 lens and a XXXX capsule tension ring.

answer: @entity4


abstract: @entity0 smoking is a major risk factor in the incidence and severity of @entity1 . Alterations of neutrophil function by short-term high levels of smoke during the act of smoking (acute smoke exposure) as well as long-term exposure to lower levels of @entity0 substances in the bloodstream (chronic smoke exposure) may play a role in the pathogenesis of @entity1 in smokers. The polymerization and depolymerization of f-actin in response to infectious agents or inflammatory mediators is a critical process in a variety of neutrophil functions. In this study, we examined the effects of in vitro smoke exposure on neutrophils from smokers and non-smokers (which may be comparable to in vivo acute smoke exposure) and neutrophils from smokers not exposed to further in vitro smoke (which may be comparable to chronic smoke exposure) on f-actin kinetics. Peripheral neutrophils were isolated from seven healthy smoking subjects and seven healthy age-matched non-smoking subjects and exposed to 1-5 min of acute smoke in a smoke box system or not exposed to further smoke (baseline controls). Selected aliquots of neutrophils from control and 5-min exposures of acute smoke were then stimulated with the chemotactic peptide @entity2 at 10(-7) M for an additional 30-360 s. Cells were fixed and permeabilized, stained for f-actin with NBD phallacidin, and analyzed by flow cytometry. From baseline to 5 min of in vitro smoke exposure, there was a 38% decline in f-actin stain in non-smokers and a 30% decline in f-actin stain in smokers (p > 0.05) with f-actin values slightly higher in smokers than-non-smokers (p > 0.05). With @entity2 stimulation, both smokers and-non-smokers demonstrated a characteristic rise in f-actin stain from 0 to 120 s with a subsequent decline to baseline at 360 s and no significant differences in f-actin levels at any time of stimulation between groups. After preincubation with 5 min of in vitro smoke, the magnitude of rise in f-actin was less in both smokers and non-smokers when compared to cells not incubated with 5 min of smoke (p < 0.05 at 120 s for both smokers and non-smokers). F-actin values in smokers were higher than-non-smokers from 30 to 360 s of @entity2 exposure (p > 0.05). These results demonstrate that in vitro smoke exposure may impair normal f-actin kinetics. These alterations in f-actin kinetics may in turn affect other neutrophil functions which may impact on the pathogenesis of @entity1 in smokers.

title: Alterations of neutrophil f-actin kinetics by XXXX smoke: implications for @entity1 .

answer: @entity0


abstract: As @entity4 is a major cause of disability and death in the western world, there is great interest in the basic mechanisms by which @entity3 /reperfusion (I/R) causes damage. To this end, extensive research has been carried out which identifies reactive @entity2 species (ROS) as key @entity0 in @entity5 resultant from I/R. Brain tissue is protected from ROS damage by antioxidant enzymes, such as @entity7 dismutase (SOD) and @entity9 peroxidase (GP). Overexpression of SOD in @entity1 has already been demonstrated to confer protection against I/R damage in @entity1 @entity4 models. We are using @entity1 overexpressing the intracellular form of @entity9 peroxidase ( @entity12 ) to determine the protective capacity of overexpression of this enzyme on @entity4 . 1 h of focal @entity11 followed by 24 h of reperfusion was induced using the intraliminal suture method. Volume of @entity8 was reduced by 48% in @entity12 @entity1 compared to nontransgenic littermates. @entity10 was reduced by 33%. @entity6 agreed with histologic data. Overexpression of @entity9 peroxidase confers significant protection against I/R damage in our @entity4 model possibly through direct scavenging of ROS or through the influencing of signalling mechanisms which lead to tissue damage.

title: Overexpression of XXXX @entity9 peroxidase protects @entity1 against focal @entity11 /reperfusion damage.

answer: @entity0


abstract: BACKGROUND: @entity5 ( @entity5 ) is the leading cause of mortality and morbidity in @entity0 following gynecologic surgery. OBJECTIVES: To determine the efficacy of a second-generation low molecular weight heparin ( @entity6 ) for thromboprophylaxis after benign gynecologic surgery. METHODS: We performed a single-blind randomized controlled trial including @entity0 in the moderate-risk, high-risk and highest-risk groups for developing @entity5 after benign gynecologic surgery. @entity0 were randomized at a 1  :  1 ratio into parallel groups to receive either seven daily doses of 3500  IU of subcutaneous @entity6 or to a non-intervention group receiving standard rehydration and advice on ambulation. @entity0 were followed up for 7  days and 30  days postoperatively for symptomatic @entity5 , which was confirmed by compression Doppler ultrasound, magnetic resonance imaging, or computed tomographic pulmonary angiography, according to the type of @entity5 . RESULTS: In total, 387 @entity0 were randomized to the @entity6 group and 387 to the non-intervention group. The incidence of symptomatic @entity5 ( @entity3 and @entity4 ) events was lower (0/377) in @entity0 who received @entity6 than in those who received no pharmacologic intervention (12/380, 3.2%; 95% confidence interval [CI]  0.002-0.6). Logistic regression analysis showed significant associations between @entity5 and immobility (odds ratio [OR]  7.1; 95%  CI  1.3-36.2), varicose veins (OR  16.8; 95%  CI  3.1-76.2), and @entity1 (OR  39.3; 95%  CI  1.5-1006.7). There were no major @entity2 events or side effects related to the use of @entity6 . CONCLUSIONS: @entity6 was an effective thromboprophylactic agent for preventing @entity1 after benign gynecologic surgery.

title: XXXX for thromboprophylaxis after benign gynecologic surgery: a randomized clinical trial.

answer: @entity6


abstract: BACKGROUND: Enrollment in health maintenance organizations (HMOs) has increased rapidly during the past 10 years, reflecting a growing emphasis on health care cost containment. To determine whether there is a difference in the treatment and outcome for female @entity1 with @entity0 enrolled in HMOs versus a fee-for-service setting, we compared the 10-year survival and initial treatment of @entity1 with @entity0 enrolled in both types of plans. METHODS: With the use of @entity2 registries covering the greater San Francisco-Oakland and Seattle-Puget Sound areas, respectively, we obtained information on the treatment and outcome for 13,358 female @entity1 with @entity0 , aged 65 years and older, diagnosed between 1985 and 1992. We linked registry information with Medicare data and data from the two large HMOs included in the study. We compared the survival and treatment differences between HMO and fee-for-service care after adjusting for @entity2 stage, comorbidity, and sociodemographic characteristics. RESULTS: In San Francisco-Oakland, the 10-year adjusted risk ratio for @entity0 among HMO @entity1 compared with fee-for-service @entity1 was 0.71 (95% confidence interval [CI] = 0.59-0.87) and was comparable for all @entity3 . In Seattle-Puget Sound, the risk ratio for @entity0 was 1.01 (95% CI = 0.77-1.33) but somewhat lower for all @entity3 . @entity1 enrolled in HMOs were more likely to receive breast-conserving surgery than @entity1 in fee-for-service (odds ratio = 1.55 in San Francisco-Oakland; 3.39 in Seattle). HMO enrollees undergoing breast-conserving surgery were also more likely to receive adjuvant radiotherapy (San Francisco-Oakland odds ratio = 2.49; Seattle odds ratio = 4.62). CONCLUSIONS: Long-term survival outcomes in the two prepaid group practice HMOs in this study were at least equal to, and possibly better than, outcomes in the fee-for-service system. In addition, the use of recommended therapy for early @entity0 was more frequent in the two HMOs.

title: XXXX survival and treatment in health maintenance organization and fee-for-service settings.

answer: @entity0


abstract: OBJECTIVE: To explore the relationship of @entity3 , @entity4 gene polymorphisms and @entity2 -DNA adduct with pathogenesis of @entity1 . METHODS: The bone marrow samples from 37 newly-diagnosed MM @entity0 and 52 healthy @entity0 as controls were collected; the PCR-based restriction fragment length polymorphism (PCR-RFLP) method was used to detecte the polymorphism of @entity3 and @entity4 , and to analysis their relationship with clinical characters of MM @entity0 ; the engyme linked immunosorbent assay (ELISA) was performed to detect the concentration of @entity2 -DNA adducts. RESULTS: @entity3 null and @entity4 null genotypes increased the risk of @entity1 with OR 2.57 (P = 0.035) and 1.37 (P > 0.05) respectively. In MM @entity0 group, @entity3 null genotype in stage III was significantly higher than that in stages I, II (P = 0.038). However, no statistically significant association was found between @entity3 gene polymorphism and clinical characters, such as age, type, hemoglobin, b2-MG, albumin. Compared with Hb >=  85 g/L of the newly-diagnosed MM @entity0 , MM @entity0 with Hb < 85 g/L had significantly higher incidence of @entity4 null genetype (P < 0.05). The level of @entity2 -DNA adducts in MM @entity0 was higher than that in controls (2358    1182 pg/ml vs 1853    996 pg/ml) (P < 0.05). @entity3 null genotype with @entity2 -DNA level >= 2100 pg/ml showed a risk index of MM (OR = 4.500, P < 0.05). CONCLUSION: @entity3 gene may have a critical function in the development of MM, and correlates with staging of MM. @entity4 gene polymorphism correlates with hemoglobin levels of @entity0 with MM. The content of @entity2 -DNA adducts may play an important role in the pathogenesis of @entity1 .

title: [Relationship of XXXX and @entity4 Gene Polymorphisms and @entity2 -DNA Adducts with Pathogenesis of @entity1 ].

answer: @entity3


abstract: BACKGROUND AND STUDY AIMS: Evidence has accumulated that approximately 15% to 30% of @entity1 ( @entity1 ) arise from serrated @entity3 (SP). Population screening, therefore, should be designated to detect advanced SP, in addition to advanced @entity2 and @entity1 . We aimed to evaluate whether @entity1 risk factors also act as risk factors for advanced SP. @entity0 AND METHODS: Data were collected in the colonoscopy arm of a multicenter randomized trial comparing colonoscopy with CT-colonography for primary population screening. Information on risk factors was obtained by screening @entity0 before colonoscopy with a validated risk questionnaire. Advanced SP were defined as SP>= 10mm and/or with @entity4 . Endoscopists were instructed to resect all detected lesions. Odds ratios (OR) for the detection of advanced SP as most advanced lesion were calculated using multiple logistic regression analysis. RESULTS: Of 6600 invited @entity0 , 1426 underwent a colonoscopy and 1236 also completed the questionnaire. In 40 @entity0 an advanced SP was the most advanced lesion detected. Multivariate analysis demonstrated a strong association between current smoking and the presence of at least one advanced SP (OR 4.50; 95% CI 2.23-8.89; P<0.001). A significant association was also demonstrated for higher fiber intake (OR 1.36 per 20 gram intake; CI 1.07-1.73; P=0.01). Other clinical @entity1 risk factors did not show a significant association with the presence of at least one advanced SP in the univariate analyses. Fecal haemoglobin levels were also not significantly associated with the presence of advanced SPs (OR 1.00 per 10ng/mL CI 0.97-1.03, P=0.99). CONCLUSIONS: Current smoking is a strong clinical risk factor for the presence of advanced SPs. As such, smoking status could contribute to risk stratification in targeted @entity1 population screening. Dutch Trial Register: NTR1829 (www.trialregister.nl).

title: Smoking status informs about the risk of advanced serrated XXXX in a screening population.

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to collect data about pediatric Gram-negative @entity2 ( @entity2 ) to determine the factors that influence @entity7 ( @entity7 ), clinical course and outcome of @entity0 affected by Gram-negative @entity3 . METHODS: In this observational, prospective, multicenter study we collected cases of pediatric Gram-negative @entity2 during a 2-year period. We analyzed epidemiological, microbiological and clinical factors that associated with acquisition of @entity7 infections and outcome. RESULTS: One-hundred and thirty-five @entity2 episodes were analyzed. Median age of @entity0 was 0.5  years (IQR 0.1-6.17, range 0-17  years). Predominant bacteria were Enterobacteriaceae (68.3  %), and Pseudomonas spp. (17.9  %). Multidrug resistance was detected in 45/134 cases (33.6  %), with the highest rates in @entity5 , Enterobacter and Pseudomonas spp. Acquisition of @entity7 pathogens was significantly associated with prior @entity8 treatment, older age, admission to hemato-oncology unit, polymicrobial infections, higher rate of development of @entity4 , and @entity6 . All-cause mortality was 17.9  %. Presence of @entity4 at presentation and parenteral nutrition were associated with higher mortality. Pseudomonas spp., and Enterobacter spp. BSIs had the highest rate of mortality. Inappropriate empiric antibiotic therapy was more frequent in @entity7 @entity0 , although not significantly associated with poor outcome. CONCLUSION: Rates of @entity7 and mortality in @entity0 with Gram-negative @entity2 remain high in our settings. Empiric broad-spectrum antibiotics and combination therapy could be recommended, especially in @entity0 with @entity1 , @entity0 admitted to the PICU, and for cases with @entity4 , who have higher mortality risk.

title: Factors influencing antimicrobial resistance and outcome of Gram-negative @entity2 in XXXX .

answer: @entity0


abstract: We have further examined the mechanism by which phorbol ester-mediated @entity10 ( @entity10 ) activation protects against @entity0 @entity1 factor ( @entity3 )-related apoptosis-inducing ligand ( @entity5 )-induced @entity2 . We now report that activation of @entity10 targets death receptor signaling complex formation. Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of @entity5 -induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased @entity11 processing, and incomplete maturation and activation of @entity4 . These effects of PMA were completely abrogated by the @entity10 inhibitor, bisindolylmaleimide I (Bis I), clearly implicating @entity10 in the protective effect of PMA. @entity5 -induced mitochondrial release of the apoptosis mediators @entity9 and @entity13 was blocked by PMA. This, together with the observed decrease in Bid cleavage, suggested that @entity10 activation modulates apical events in @entity5 signaling upstream of mitochondria. This was confirmed by analysis of @entity5 death-inducing signaling complex formation, which was disrupted in PMA-treated cells as evidenced by a marked reduction in @entity14 ( @entity14 ) recruitment, an effect that could not be explained by any change in @entity14 phosphorylation state. In an in vitro binding assay, the intracellular domains of both @entity6 and @entity7 bound @entity14 : activation of @entity10 significantly inhibited this interaction suggesting that @entity10 may be targeting key apical components of death receptor signaling. Significantly, this effect was not confined to @entity5 , because isolation of the native @entity3 receptor signaling complex revealed that @entity10 activation also inhibited @entity3 receptor-associated death domain protein recruitment to @entity12 and @entity3 -induced phosphorylation of @entity8 . Taken together, these results show that @entity10 activation specifically inhibits the recruitment of key obligatory death domain-containing adaptor proteins to their respective membrane-associated signaling complexes, thereby modulating @entity5 -induced apoptosis and @entity3 -induced NF-kappaB activation, respectively.

title: Protein kinase C modulates XXXX @entity1 factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

answer: @entity0


abstract: PURPOSE: This study sought to quantify the risk of @entity3 ( @entity3 ) in @entity1 ( @entity1 ) @entity0 receiving mediastinal @entity2 ( @entity2 ) and to identify predictive factors for @entity3 . METHODS AND MATERIALS: We identified 75 @entity0 with newly diagnosed @entity1 treated with mediastinal @entity2 and 17 @entity0 with relapsed/refractory @entity1 treated with mediastinal @entity2 before or after transplant. Lung dose-volumetric parameters including mean lung dose and percentage of lungs receiving 20 Gy were calculated. Factors associated with @entity3 were explored by use of the Fisher exact test. RESULTS: @entity3 developed in 7 @entity0 (10%) who received mediastinal @entity2 as part of initial therapy (Radiation Therapy Oncology Group Grade 1 in 6 cases). A mean lung dose of 13.5 Gy or greater (p = 0.04) and percentage of lungs receiving 20 Gy of 33.5% or greater (p = 0.009) significantly predicted for @entity3 . @entity3 developed in 6 @entity0 (35%) with relapsed/refractory @entity1 treated with peri-transplant mediastinal @entity2 (Grade 3 in 4 cases). Pre-transplant mediastinal @entity2 , compared with post-transplant mediastinal @entity2 , significantly predicted for Grade 3 @entity3 (57% vs. 0%, p = 0.015). CONCLUSIONS: We identified threshold lung metrics predicting for @entity3 in @entity1 @entity0 receiving mediastinal @entity2 as part of initial therapy, with the majority of cases being of mild severity. The risk of @entity3 is significantly higher with peri-transplant mediastinal @entity2 , especially among those who receive pre-transplant @entity2 .

title: Predictive factors for @entity3 in @entity1 XXXX receiving combined-modality therapy.

answer: @entity0


abstract: BACKGROUND: Pylephlebitis or septic @entity5 of the portal venous system is a rare but serious complication of @entity4 which drain into the portal venous system. Its diagnosis is based on clinical suspicion and imaging tests, mainly a computed tomography scan, given the lack of specificity of the signs and symptoms. Spread of @entity3 is the major cause of morbidity and mortality. The aim of the study was to analyse @entity0 diagnosed in our hospital. MATERIAL AND METHODS: Retrospective descriptive study of @entity0 diagnosed with pylephlebitis in our hospital. CLINICAL CASES: Four @entity0 were included, 3 @entity0 and one @entity0 . In 3 cases it was acute @entity6 that led to the diagnosis of pylephlebitis at the same time as the @entity4 . Emergency surgery was performed in one case, whilst the other 2 were treated conservatively. Blood cultures were performed in all cases, and empirical antibiotic treatment was used. In the only case of @entity2 , diagnosis of pylephlebitis was achieved during the study of @entity1 , with empirical antibiotic treatment also being started. The haematologist was requested to start the required anticoagulation therapy in all cases. CONCLUSIONS: Pylephlebitis is a rare complication of @entity4 that may make lead to a worse outcome. A high level of suspicion is required as well as imaging tests to make an early diagnosis and appropriate treatment.

title: [Pylephlebitis: a rare but possible complication of XXXX ].

answer: @entity4


abstract: BACKGROUND: Identification of reliable targets for therapeutic interventions is essential for developing evidence-based therapies. Threat-related attention bias has been implicated in the etiology and maintenance of @entity1 . Extant response-time-based threat bias measures have demonstrated limited reliability and internal consistency. Here, we examined gaze patterns of socially anxious and nonanxious @entity0 in relation to social threatening and neutral stimuli using an eye-tracking task, comprised of multiple threat and neutral stimuli, presented for an extended time-period. We tested the psychometric properties of this task with the hope to provide a solid stepping-stone for future treatment development. METHODS: Eye gaze was tracked while @entity0 freely viewed 60 different matrices comprised of eight disgusted and eight neutral facial expressions, presented for 6000ms each. Gaze patterns on threat and neutral areas of interest (AOIs) of @entity0 with @entity2 , high socially anxious students and nonanxious students were compared. Internal consistency and test-retest reliability were evaluated. RESULTS: @entity0 did not differ on first-fixation variables. However, overall, socially anxious students and @entity0 with @entity2 dwelled significantly longer on threat faces compared with nonanxious @entity0 , with no difference between the anxious groups. Groups did not differ in overall dwell time on neutral faces. Internal consistency of total dwell time on threat and neutral AOIs was high and one-week test-retest reliability was acceptable. LIMITATIONS: Only disgusted facial expressions were used. Relative small sample size. CONCLUSION: @entity1 is associated with increased dwell time on socially threatening stimuli, presenting a potential target for therapeutic intervention.

title: XXXX is related to increased dwell time on socially threatening faces.

answer: @entity1


abstract: The purpose of this study was to investigate the frequency of @entity5 overexpression in the primary @entity4 of @entity0 with @entity1 (SBTs) and to determine the relationship between @entity5 overexpression and risk of progression/recurrence and survival. Of 112 @entity0 with stages II-IV SBTs, @entity6 -embedded tissue from the primary @entity4 was available in 68 cases. Immunohistochemical staining for @entity5 was performed. Clinical information was abstracted from the medical records. The major end points selected for analysis were time to progression/relapse, disease-free survival, overall survival, and cause-specific survival. Univariate and multivariate regression analyses were also performed. The median @entity0 age was 37 years (range, 17-67 years). Twenty-two @entity0 had @entity2 , and 46 had @entity1 . The mean follow-up time was 105 months. Nineteen @entity0 (28%) had either disease progression (1 @entity0 ) or relapse (18 @entity0 ). Eleven @entity0 died: 10 @entity0 died of their @entity1 , and 1 @entity0 died of other causes. Thirteen cases (19%) had positive immunostaining for @entity5 . Overexpression of @entity5 was significantly associated with an increased probability of progression/recurrence (P = 0.005) and a decreased overall survival (P = 0.012). After adjusting for age, International Federation of Gynecology and Obstetrics (FIGO) stage, the presence of @entity3 , and the presence of invasive implants, @entity0 whose @entity1 overexpressed @entity5 had a 4-fold increased risk of progression/ recurrence. Similarly, @entity0 whose @entity1 overexpressed @entity5 had an approximately 6-fold increased risk of death. @entity5 overexpression in the @entity4 of @entity0 with stage II and III SBTs is significantly associated with increased probability of relapse and decreased overall survival. This information should provide better prognostic data to @entity0 and their families and allow us to select @entity0 who might benefit from postoperative treatment.

title: Prognostic significance of @entity5 expression in XXXX .

answer: @entity4


abstract: BACKGROUND: The authors sought to demonstrate the safety and effectiveness of the multilevel stabilization screw (MLSS) technique in decreasing the incidence of proximal junctional failure in long segmental instrumented fusions for @entity3 . METHODS: Institutional review board approval was obtained and all @entity0 with adult @entity2 who underwent the MLSS technique were analyzed. A neuro-radiologist and spine-focused neurosurgeon not involved with the surgical treatment performed radiographic analysis. Proximal junctional angle was defined as the caudal endplate of the upper instrumented vertebra (UIV) to the cephalad endplate of two supradjacent vertebrae above the UIV. The UIV is defined as the most cephalad vertebra completed captured by the instrumentation. Abnormal proximal junctional kyphosis (PJK) was defined as proximal junctional sagittal Cobb angle >10 degrees and proximal junction sagittal Cobb angle at least 10 degrees greater than the preoperative measurement. The presence of both is criteria necessary to be considered abnormal. RESULTS: Twenty @entity0 with @entity3 underwent the MLSS technique with the upper-instrumented vertebrae in the proximal thoracic spine. Fifteen @entity0 met inclusion criteria with greater than 12 months radiographic and clinical follow up. Three @entity0 were excluded due to lack of follow up imaging and two @entity0 were excluded due to the inability to measure the UIV. Age range was 44-84 years with a mean of 66. Eleven of the 15 @entity0 were over the age of 60 at the time of surgery. The male-to-female ratio was 4:11. Body mass index (BMI) range was 24-44 with a mean of 31.5 units. The follow up period ranged from 14 to 58 months with an average follow up of 30 months. The mean change in Cobb angle at the proximal junction was 4.00 degrees with a range from -0.92 to 9.13 degrees. There were no fractures or instrumentation failures at or near the proximal junction. There was no revision surgeries performed for proximal junctional failure. Retrospective clinical questionnaires revealed that surgical expectations were met in 15 of 19 @entity0 surveyed, 79%. One @entity0 was not reachable for a postoperative phone interview. In @entity0 who were not satisfied with their overall experience, the change in Cobb angle ranged from -0.92 to 9.13 degrees with an average change of 3.90 degrees. Whereas @entity0 reporting an overall positive experience had a change in Cobb angle range from -0.12 to 8.07 degrees with an average change of 4.05 degrees. CONCLUSION: PJK and failure are well-recognized suboptimal outcomes of long-segmental fusions of the thoracolumbar spine that can lead to significant @entity1 and costly revision surgeries. With no known proximal junction failures to date, the MLSS technique has shown promising results in preventing adverse proximal junctional conditions and can be safely performed under fluoroscopy guidance. Future direction includes a comparative study establishing the relative risk of developing PJK with this novel technique versus a traditional long-segmental thoracolumbar fusion.

title: Preventing proximal junctional failure in long segmental instrumented cases of XXXX using a multilevel stabilization screw technique.

answer: @entity3


abstract: The present paper describes the clinical and radiographic healing results of 27 implants followed from 1 to 3 years after functional implant loading. Prior to implant placement, @entity1 with insufficient bone volume were augmented using autogenous bone grafts and a micro @entity3 mesh for graft stabilization. After a mean interval of 5.2 months implants were installed. Following an osseointegration period of on average 7.2 months, implants were supplied with suprastructures. The mean loading period for the 27 implants was 21 months. All implants exhibited ankylotic stability and healthy peri-implant soft tissues. The detailed analysis of clinical parameters (probing depth, level of mucosal margin, attachment level, modified plaque and sulcus bleeding indices) and radiographic measurements (crestal bone level), revealed findings similar to those at implants placed into non-augmented bone. Peri-implant bone resorption was calculated to be 1.0 mm for the 1st year after implant loading and 0.1 mm for the following year. @entity2 , @entity0 were absent at all implants. It was concluded that loaded dental implants which have been inserted into an @entity1 using autogenous bone grafts and a micro @entity3 mesh for graft stabilization, demonstrate clinical and radiographic findings similar to those of implants placed into a pristine ridge.

title: Localized ridge augmentation using a micro XXXX mesh: a report on 27 implants followed from 1 to 3 years after functional loading.

answer: @entity3


abstract: Rapid osseointegration is recognized as a critical factor in determining the success rate of orthopedic and dental implants. Microarc oxidation (MAO) fabricated @entity3 coatings with a porous topography have been proven to be a potent approach to enhance osteogenic capacity. Now we report two kinds of new @entity4 with similar micromorphologies but different nanotopographies (i.e., MAO and MAO-AK coatings), and both coatings significantly promote cell attachment and osteogenic differentiation through mediating the integrin b1 signaling pathway. In this study, @entity1 with a unique hierarchical micro/nanomorphology surface was fabricated by a novel duplex coating process, that is, the first a @entity3 layer was coated by MAO, and then the coating was electrochemically reduced in alkaline solution (MAO-AK). A series of in vitro stem cell differentiation and in vivo osseointegration experiments were carried out to evaluate the osteogenic capacity of the resulting coatings. In vitro, the initial adhesion of the @entity0 bone marrow stem cells (BMSCs) seeded on the MAO and MAO-AK coatings was significantly enhanced, and cell proliferation was promoted. In addition, the expression levels of osteogenesis-related genes, osteorix, alkaline @entity2 (ALP), osteopontin, and osteocalcin, in the @entity0 BMSCs, were all up-regulated after incubation on these coatings, especially on the MAO-AK coating. Also, the in vitro ALP activity and mineralization capacity of @entity0 BMSC cultured on the MAO-AK group was better than that on the MAO group. Furthermore, 6 weeks after insertion of the @entity1 implants into @entity0 femurs, both the bone formation speed and the bone-implant contact ratio of the MAO-AK group were significantly higher than those of the MAO group. All these results suggest that this duplex coating process is promising for engineering @entity1 surfaces to promote osseointegration for dental and orthopedic applications.

title: Enhanced Osseointegration of Hierarchical Micro/Nanotopographic XXXX Fabricated by Microarc Oxidation and Electrochemical Treatment.

answer: @entity1


abstract: UNASSIGNED: @entity6 ( @entity6 ) is a frequent @entity2 seen in @entity0 and adolescents with @entity1 ( @entity1 ). @entity6 is also a common antecedent to both @entity7 and @entity2 . Although the heritability of @entity6 has been estimated to be around 0.60, there has been little research into the molecular genetics of @entity6 . The present study examined the association of irritable and defiant/vindictive dimensions and categorical subtypes of @entity6 (based on latent class analyses) with previously described specific polymorphisms ( @entity9 exon3 VNTR, 5-HTTLPR, and seven @entity10 SNPs) as well as with @entity5 , @entity4 , and @entity3 genes and pathways in a clinical sample of @entity0 and adolescents with @entity1 . In addition, we performed a multivariate genome-wide association study (GWAS) of the aforementioned @entity6 dimensions and subtypes. Apart from adjusting the analyses for age and sex, we controlled for "parental ability to cope with disruptive behavior." None of the hypothesis-driven analyses revealed a significant association with @entity6 dimensions and subtypes. Inadequate parenting behavior was significantly associated with all @entity6 dimensions and subtypes, most strongly with defiant/vindictive behaviors. In addition, the GWAS did not result in genome-wide significant findings but bioinformatics and literature analyses revealed that the proteins encoded by 28 of the 53 top-ranked genes functionally interact in a molecular landscape centered around @entity8 signaling and involved in the regulation of neurite outgrowth. Our findings provide new insights into the molecular basis of @entity6 and inform future genetic studies of oppositional behavior.    2015 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

title: Gene-set and multivariate genome-wide association analysis of oppositional defiant behavior subtypes in XXXX .

answer: @entity1


abstract: BACKGROUND: @entity2 has been estimated to cause >2500 illnesses and 500 deaths annually in the United States. Efforts to reduce foodborne listeriosis have focused on foods frequently implicated in outbreaks. Potential sources for @entity2 infection not associated with outbreaks remain poorly understood. METHODS: The @entity3 Active Surveillance Network conducts surveillance for culture-confirmed listeriosis at clinical laboratories in 9 states. After excluding outbreak-associated cases, we attempted to enroll eligible case @entity0 with @entity2 infection in a case-control study from 2000 through 2003. Control subjects were recruited through health care providers and were matched to case @entity0 by state, age, and immunosuppression status. Data were collected about exposures occurring in the 4 weeks before specimen collection from the case @entity0 . RESULTS: Of the 249 case @entity0 with @entity2 infection, only 12 (5%) had cases that were associated with outbreaks; 6 other @entity0 were ineligible for other reasons. Of 231 eligible case @entity0 , 169 (73%) were enrolled in the study. We classified 28 case @entity0 as having pregnancy-associated cases. We enrolled 376 control subjects. In multivariable analysis, @entity2 infection was associated with eating melons at a commercial establishment (odds ratio, 2.6; 95% confidence interval, 1.4-5.0) and eating hummus prepared in a commercial establishment (odds ratio, 5.7; 95% confidence interval, 1.7-19.1). CONCLUSIONS: Most cases of @entity2 infection were not associated with outbreaks. Reducing the @entity1 may require interventions directed at retail environments and at foods, such as melons and hummus, that are not commonly recognized as high risk. Because of the severity of listeriosis, pregnant @entity0 and other @entity0 at risk may wish to avoid eating these newly implicated foods.

title: XXXX infection from foods prepared in a commercial establishment: a case-control study of potential sources of sporadic illness in the United States.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) has been an important complication of cardiac surgery over the years. @entity3 can affect quality of life and lead to social, functional, emotional, and financial problems in the @entity0 's life. To reduce @entity2 , we sought to identify the association between @entity2 and perioperative factors in @entity0 undergoing cardiac surgery. METHODS: One hundred one @entity0 aged between 45 and 75 years undergoing elective cardiac surgery were enrolled in this study. All the surgeries were performed on-pump by the same medical team. A brief @entity8 ( @entity8 ) was administered before surgery, 3 to 5 days after the surgery, and 3 months after discharge. All related perioperative parameters were collected in order to study the effect of these parameters on the postoperative @entity8 scores and @entity8 score change. RESULTS: The study population consisted of 101 @entity0 , comprising 14 (13.8%) females and 87 (86.2%) males aged between 45 and 75 years. In univariate analysis, the baseline @entity8 score, serum levels of @entity4 dehydrogenase and T3, cross-clamp time, and preexistence of @entity6 showed significant effects on the postoperative @entity8 score (p value < 0.05), whereas only the baseline @entity8 score and @entity6 showed strong effects on the postoperative @entity8 score in the multiple regression model. In addition, the multiple regression model demonstrated a significant association between the baseline @entity8 score, serum @entity5 level, and @entity7 administration and the @entity8 score change. CONCLUSION: Our study showed that preexisting @entity6 and preoperative high serum @entity5 levels negatively affected cognitive function after surgery. In addition, there was a strong relationship between the @entity0 ' basic cognition and @entity2 . Preoperative @entity7 administration led to a significant improvement in @entity2 . It is also concluded that the preoperative administration of specific medicines like @entity9 can reduce @entity1 after cardiac surgery.

title: Association between Perioperative Parameters and @entity2 in Post-Cardiac Surgery XXXX .

answer: @entity0


abstract: Between April 1980 and December 1999, 23 kidneys in 20 @entity0 were diagnosed as having @entity2 at our institution. The @entity0 were 6 males and 14 females aged 24 to 79 years, with a mean age of 55.4 years. Two @entity0 had associated @entity5 and 3 had bilateral disease. Of all @entity0 the main clinical symptoms were @entity3 (45%) and palpable mass (40%); 5 @entity0 (25%) had asymptomatic lesions. The size of the @entity1 ranged from 1.3 to 24 cm (mean 7.7 cm). Treatment consisted of nephrectomy in 9 @entity0 , partial nephrectomy in 6 and selective embolization in one. Pre-operative diagnosis was @entity4 in 5 of the 9 @entity0 who underwent nephrectomy. Six @entity0 with 7 diseased kidneys were followed radiologically. One @entity0 underwent percutaneous biopsy to confirm the diagnosis. We suggest that nephron-sparing surgery for @entity0 with @entity2 should be the first step if @entity1 size is 4 cm < or = or increasing rapidly. Selective embolization is also a useful method. However, we need long-term follow-up to evaluate the effectiveness of embolization.

title: [Clinical evaluation of XXXX ].

answer: @entity2


abstract: Seventeen staged, bilateral total hip arthroplasties performed in 17 @entity0 were reviewed to compare side-to-side @entity1 wear. Implants used on both sides were similar except for implant offset: one hip in each @entity0 was replaced using a femoral component having a standard implant offset, whereas the other side had a lateral offset implant. The mean followup was 5.70 years (range, 2-10.2 years) on the side with a standard femoral implant and 5.67 years (range, 2-9.7 years) on the side with a lateralized femoral component. The only statistically different parameter between the sides was the femoral component offset. All other parameters affecting @entity1 wear, such as period of followup, head size, head type, cup size, cup inclination, medialization of cup, and @entity0 -related factors were similar on both sides. On the side with a standard femoral component, the mean actual prosthetic offset (determined by manufacturer's specifications) was 35.2 mm and the radiologic offset was 31.5 mm. On the side with a lateralized femoral component, the actual prosthetic offset was 42.5 mm and the radiologic offset was 40.1 mm. The difference in offsets between the sides was statistically significant. The mean preoperative offset of the femur was 38.8 mm. Regression analysis revealed that only femoral component offset and cup size correlated significantly with linear wear rate. On the side with a standard femoral component, the linear wear rate was 0.21 mm per year, whereas on the side with a lateralized femoral component, the linear wear rate was 0.10 mm per year. The differences in the linear wear rates were significant. Lateralization of the femoral component in this series more closely restored preoperative hip biomechanics and significantly decreased @entity1 wear.

title: Effect of femoral component offset on XXXX wear in total hip arthroplasty.

answer: @entity1


abstract: BACKGROUND: Malignant @entity1 is commonly treated surgically. @entity1 are a therapeutic option for palliation or used as a bridge to surgery or chemotherapy. OBJECTIVE: The aim of the study was to evaluate the clinical success rate of stenting as a bridge to one-step surgery, chemotherapy, or as a palliative measure. DESIGN: This was a retrospective observational study. SETTINGS: The study was conducted at a university-affiliated tertiary referral center. @entity0 AND INTERVENTIONS: From 2007 to 2014, 45 @entity0 with @entity1 were referred for stent insertion. MAIN OUTCOME MEASURES: @entity0 were grouped according to three pre-defined treatment goals: group 1: restorative one-step procedure without an ostomy, group 2: completion of scheduled chemotherapy before surgery, and group 3: palliation without surgical intervention. RESULTS: Group 1 included 11 @entity0 . Three @entity0 (27.3  %) met the treatment goal of one-step surgery. Eight @entity0 (72.7  %) did not reach the primary goal due to stent insertion failure (four @entity0 ), stent-related complications (two @entity0 ), and failure to perform a one-step surgery after successful stent insertion (two @entity0 ). Group 2 included 12 @entity0 . Chemotherapy was successfully completed prior to surgery in six @entity0 (50  %). Six @entity0 (50  %) did not achieve treatment goal due to stent insertion failure (two @entity0 ), stent migration (two @entity0 ), stent-related perforation (one @entity0 ), and mortality (one @entity0 ). Group 3 included 20 @entity0 . Long-term palliation without surgical intervention was achieved in eight @entity0 (40  %). Stent insertion failed in seven @entity0 (35  %). Five @entity0 (25  %) needed urgent surgery due to stent complications (three migrations and two perforations). LIMITATIONS: The study was limited by its retrospective nature and small sample size. CONCLUSIONS: This study demonstrates only a modest success rate of colonic stents in the treatment of @entity1 . Although colonic stenting seems to be an effective method of relieving @entity1 , high failure rates limits its applicability.

title: Stenting in XXXX -is it a real therapeutic option?

answer: @entity1


abstract: AIM: Many perianal fistulae in @entity1 do not respond to conventional surgical and medical management and recurrence rates are high. The study evaluated the safety and feasibility of allogeneic adipose-derived stem cells for the treatment of @entity2 in @entity1 . METHOD: A multicentre, open-label, dose escalation pilot study was performed. The first three @entity0 (group 1) were administered 1  *  10(7) cells/ml based on the size of the @entity2 tract. Four  weeks later, after which time this dose had been confirmed to be safe, the next three @entity0 (group 2) were administered 3  *  10(7) cells/ml. The end-point was complete closure at 8  weeks after the injection. @entity0 who attended for the 8  week assessment were followed for an additional 6  months. RESULTS: There were no adverse events of Grade 3 or 4 severity and no adverse events related to the treatment with allogeneic adipose-derived stem cells. Two @entity0 in group 1 achieved complete closure of the @entity2 at month 4 and month 6, and one @entity0 in group 2 achieved complete closure at 8  weeks. The closure was sustained up to month 8 in all three of those @entity0 . CONCLUSION: These data suggest that allogeneic adipose-derived stem cells may be a feasible treatment option for @entity2 in @entity1 .

title: Allogeneic adipose-derived stem cells for the treatment of @entity2 in XXXX : a pilot clinical trial.

answer: @entity1


abstract: UNASSIGNED: @entity10 is the fourth most common @entity1 in @entity0 , has an even higher incidence in adolescents, and is primarily represented by only a few histologic subtypes. Dramatic progress has been achieved, with survival rates exceeding 80%, in large part because of a better understanding of the biology of the different subtypes and national and international collaborations. Most @entity0 with @entity12 and diffuse large @entity9 are cured with short intensive pulse chemotherapy containing @entity5 , @entity13 , and high-dose @entity7 . The benefit of the addition of rituximab has not been established except in the case of primary mediastinal @entity9 . @entity6 is treated with intensive, semi-continuous, @entity8 -derived protocols. Relapses in @entity9 are rare and infrequently curable, even with intensive approaches. Event-free survival rates of approximately 75% have been achieved in @entity11 with various regimens that generally include a short intensive B-like regimen. Immunity seems to play an important role in prognosis and needs further exploration to determine its therapeutic application. @entity14 inhibitor therapeutic approaches are currently under investigation. For all @entity4 , the intensity of induction/consolidation therapy correlates with acute @entity3 , but because of low cumulative doses of @entity15 and alkylating agents, minimal or no long-term @entity3 is expected. Challenges that remain include defining the value of prognostic factors, such as early response on positron emission tomography/computed tomography and minimal disseminated and @entity2 , using new biologic technologies to improve risk stratification, and developing innovative therapies, both in the first-line setting and for relapse.

title: @entity10 in XXXX and Adolescents: Progress Through Effective Collaboration, Current Knowledge, and Challenges Ahead.

answer: @entity0


abstract: UNASSIGNED: Background   Locally advanced @entity0 (LABC) and @entity2 (ORN) often require extensive and composite tissue resection, including muscles, ribs, @entity1 . As such, these cases necessitate complex reconstructive procedures for skeletal chest wall reconstruction and soft tissue resurfacing of extensive defects. Traditional local and regional flaps are often inadequate, and many such cases are prospectively labeled "unresectable." Methods   We report a single-center experience with the microsurgical reconstruction of such defects over a 5-year period. Between 2007 and 2011, 1,077 microvascular reconstructive cases following @entity0 resection were performed, of which 26 cases comprised LABC or ORN requiring reconstruction. Surgical indications, defect parameters, choice of reconstruction, and outcomes were assessed. Results   Thirty free flap microsurgical reconstructions were undertaken in 26 cases, with a 96.2% flap survival rate. Complications were low, and mean hospital stay was 8.7 days. An algorithmic approach to management is presented. Conclusion   Wide resection and microvascular free tissue transfer provide versatile solutions for the reconstruction of extensive @entity2 . With good reported perioperative outcomes even in advanced cases, surgical resection of LABC may offer a useful approach in difficult and/or palliative cases.

title: Microsurgical Reconstruction of Large Oncologic Chest Wall Defects for Locally Advanced XXXX or Osteoradionecrosis: A Retrospective Review of 26 Cases over a 5-Year Period.

answer: @entity0


abstract: BACKGROUND: @entity0 with @entity2 ( @entity2 ) and @entity3 are often managed with intrathecal @entity4 treatment (ITB). Complications of ITB include @entity1 at the pump or catheter site and late complications as well as revisions of the pump and catheter because of events such as battery expiration or implant malfunction. The goal of this study is to report the short-term and long-term incidence, risk factors, and treatment outcomes of @entity1 in @entity0 . METHODS: This was a retrospective review of 294 @entity0 with @entity2 . The number of ITB surgeries per @entity0 , risk of @entity1 for primary and secondary ITB-related procedures, microorganisms responsible, and associated factors, such as concurrent orthopaedic interventions, medical comorbidities, and subsequent management of ITB-related @entity1 , were evaluated. RESULTS: Infection occurred in 28/294 @entity0 (9.5%) with a 4.9% rate per procedure. There were 14 acute (within 90 d of surgery) and 14 late @entity1 . The @entity1 risk per ITB procedure was 2.4%. Risk of late @entity1 over 5-year mean follow-up was 0.95% per year. Pump removal with acute contralateral implantation was the most successful treatment of @entity1 . Gross Motor Function Classification System level V and G-tube were the main risk factors for @entity1 . A total of 133 concurrent orthopaedic procedures were performed during 277 ITB procedures with no increased risk of @entity1 . CONCLUSIONS: ITB in @entity0 with @entity2 has a relatively low and manageable risk of @entity1 . It is important to always consider @entity1 as a complication with ITB because with prompt treatment the positive impact of ITB is still possible. It is safe to perform concurrent orthopaedic procedures with ITB procedures. LEVELS OF EVIDENCE: Level III-therapeutic study.

title: Infection as a Complication of Intrathecal XXXX Treatment in @entity0 With @entity2 .

answer: @entity4


abstract: OBJECTIVE: Micro RNAs (miRNAs) are a class of non-coding regulatory RNAs. We performed a transcriptome-wide analysis of subcutaneous adipose tissue and in vitro studies to identify miRNAs and co-regulated target transcripts associated with insulin sensitivity (SI) and @entity1 in @entity0 . METHODS: We selected 20 insulin-resistant (IR, SI=2.0  0.7) and 20 insulin-sensitive (IS, SI=7.2  2.3) subjects from a cohort of 117 metabolically characterized non-diabetic Caucasians for comparison. RESULTS: After global profiling, 3 miRNAs had marginally different expressions between IR and IS subjects. A total of 14 miRNAs were significantly correlated with %fat mass, body mass index (BMI), or SI. The qRT-PCR validated the correlation of @entity2 -148a-3p with BMI (r=-0.70, P=2.73X10-6). MiRNA target filtering analysis identified @entity3 ( @entity3 ) as one of the target genes of @entity2 -148a-3p. @entity3 expression in adipose tissue was positively correlated with BMI (r=0.47, p=8.42X10-7) and was inversely correlated with @entity2 -148a-3p (r=-0.34). Differentiation of @entity4 preadipocytes showed up-regulation of @entity2 -148a-3p and down-regulation of @entity3 in differentiated adipocytes. After transfecting @entity2 -148a-3p mimics into HeLa-S3 cells, @entity3 was down-regulated, while transfection of adipose stem cells with @entity2 -148a-3p inhibitor up-regulated @entity3 . CONCLUSIONS: Our results indicate that @entity2 -148a-3p-mediated regulation of @entity3 expression may play a mechanistic role in @entity1 .

title: Obesity associated modulation of miRNA and co-regulated target transcripts in XXXX adipose tissue of non-diabetic subjects.

answer: @entity0


abstract: INTRODUCTION: Measurement of @entity1 response by standard response criteria is challenging in @entity5 , especially when the pleura is involved, as it often is in stage IV disease. In this study, we aimed to determine the effectiveness of volumetric response evaluation criteria in @entity1 (volumetrics) for evaluating response in @entity0 with @entity5 treated on a phase II study of @entity6 . METHODS: We evaluated the @entity1 responses of 25 @entity0 with @entity4 using computed tomography-based RECIST, World Health Organization (WHO), modified RECIST, and volumetrics. As a control, we assessed 37 @entity0 with @entity3 ( @entity3 ) with RECIST and volumetrics. RESULTS: Agreement analyses in 23 @entity0 with @entity4 at the time of RECIST-determined @entity2 ( @entity2 ) compared volumetrics with RECIST, modified RECIST, and WHO criteria. Use of volumetrics was associated with 22% discordance compared with RECIST, 15% versus modified RECIST, and 22% versus WHO criteria. Volumetrics revealed @entity2 72 days earlier than RECIST (p = 0.016). In another cohort of 35 @entity0 with @entity3 , there was 9% discordance between volumetrics and RECIST at the time of @entity2 . Volumetrics demonstrated @entity2 32 days earlier than RECIST in @entity3 (p = 0.0078). CONCLUSIONS: Our study suggests that volumetrics might improve detection of @entity2 . Prospective evaluation of this technique in a larger series of @entity0 with @entity5 will be required.

title: Assessment of objective responses using volumetric evaluation in advanced @entity5 and metastatic XXXX .

answer: @entity3


abstract: BACKGROUND: Aberrant Notch activation confers a proliferative advantage to many @entity0 @entity1 , including @entity3 . This phase 2 trial assessed the antitumor activity of @entity6 , a gamma-secretase inhibitor of Notch signaling, with respect to the progression-free and overall survival of @entity0 with advanced @entity3 . METHODS: Chemotherapy-naive @entity0 with @entity3 of cutaneous or unknown origin were treated orally with @entity6 at a dose of 20 mg daily 3 consecutive days per week. A 2-step accrual design was used with an interim analysis of the first 32 @entity0 and with continuation of enrollment if 4 or more of the 32 @entity0 responded. RESULTS: Thirty-six @entity0 from 23 institutions were enrolled; 32 @entity0 were evaluable. @entity6 was well tolerated, and most @entity2 were grade 1 or 2. The most common @entity2 were @entity4 (53%), @entity8 (41%), and @entity5 (22%). There was 1 confirmed partial response lasting 7 months, and there were 8 @entity0 with stable disease lasting at least through week 12, with 1 of these continuing for 31 months. The 6-month progression-free survival rate was 9% (95% confidence interval [CI], 2%-22%), and the 1-year overall survival rate was 50% (95% CI, 32%-66%). Peripheral blood T-cell assays showed no significant inhibition of the production of @entity7 , a surrogate pharmacodynamic marker of Notch inhibition, and this suggested that the drug levels were insufficient to achieve Notch target inhibition. CONCLUSIONS: @entity6 showed minimal clinical activity against @entity3 in this phase 2 trial, possibly because of inadequate exposure to therapeutic drug levels. Although Notch inhibition remains a compelling target in @entity3 , the results do not support further investigation of @entity6 with this dose and schedule. @entity1 2014.    2014 American @entity1 Society.

title: Phase 2 study of @entity6 , a gamma-secretase inhibitor, in XXXX : SWOG 0933.

answer: @entity3


abstract: We tested and clinically validated a targeted next-generation sequencing (NGS) mutation panel using 80 @entity3 -fixed, @entity7 -embedded (FFPE) @entity0 samples. Forty @entity8 ( @entity8 ), 30 @entity1 , and 30 gastrointestinal (12 colonic, 10 gastric, and 8 @entity4 ) FFPE samples were selected from laboratory archives. After appropriate specimen and nucleic acid quality control, 80 NGS libraries were prepared using the Illumina @entity0 ( @entity0 ) kit and sequenced on the Illumina MiSeq. Sequence alignment, variant calling, and sequencing quality control were performed using vendor software and laboratory-developed analysis workflows. @entity0 generated >= 500* coverage for 98.4% of the 13,952 targeted bases. Reproducible and accurate variant calling was achieved at >= 5% variant allele frequency with 8 to 12 multiplexed samples per MiSeq flow cell. @entity0 detected 112 variants overall, and confirmed all known single- @entity9 variants (n = 27), deletions (n = 5), insertions (n = 3), and multinucleotide variants (n = 3). @entity0 detected at least one variant in 85.0% (68/80), and two or more variants in 36.2% (29/80), of samples. @entity6 was the most frequently mutated gene in @entity8 (13  variants; 13/32 samples), @entity2 (15 variants; 13/25 samples), and overall (30 variants; 28/80 samples). @entity5 mutations were most common in @entity1 (nine variants; 9/23 samples). Clinically relevant NGS data can be obtained from routine clinical FFPE solid @entity0 specimens using @entity0 , benchtop instruments, and vendor-supplied bioinformatics pipelines.

title: Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, @entity1 , and XXXX .

answer: @entity2


abstract: We prospectively studied the type, frequency and outcome of @entity4 in 513 @entity0 with 762 consecutive episodes of @entity8 ( @entity8 ) over a five-year period between 1995 and 1999 in a single paediatric oncology unit. The findings were then compared with a similar study carried out in our unit between 1990 and 1994. The types of bacterial isolates and sensitivity patterns were also studied to identify trends and to gauge the suitability of antibiotics chosen for empirical therapy. @entity7 was documented in 35.4% of @entity8 episodes, although 70% of @entity0 did not have an obvious site of @entity5 . The majority of isolates (61.9%) were gram-negative bacteria, a consistent finding throughout the study period. Resistance to @entity12 , @entity11 and imipenem among gram-negative bacteria was 26.3%, 21.2% and 0.7%, respectively. Methicillin resistance among gram-positive bacteria was 26.3%, while no @entity9 -resistant bacteria were encountered. There were 36 @entity5 -related @entity2 . Factors associated with a fatal outome were prolonged capillary refill time, @entity6 , @entity3 above 39 degrees C and @entity1 . Rapid neutrophil recovery was associated with a good prognosis. A change to our current choice of empirical antibiotics for @entity8 , comprising @entity12 / @entity10 and @entity11 appears necessary because of the relatively high resistance rates found.

title: Surveillance study of bacteraemic episodes in febrile neutropenic XXXX .

answer: @entity0


abstract: The influences of test variables on the outcome of susceptibility testing with @entity3 were tested with isolates of Candida spp. and @entity0 . Among six growth conditions tested with a range of inoculum sizes, the highest control growth yields were obtained in Sabouraud broth for all fungi, followed by RPMI 1640 (pH 7) for Candida spp. and antibiotic medium 3 ( @entity4 ) for A. fumigatus. RPMI 1640 gave unacceptably low growth yields with A. fumigatus. The @entity3 MICs under these various conditions ranged over more than 4 twofold dilutions for 7 of 16 fungi tested when a 50% inhibition (50% inhibitory concentration [IC(50)]) endpoint was used and for 12 of 16 fungi tested when an 80% inhibition (IC(80)) endpoint was used. A multifactorial design to study the influences of six test variables on control growth and the MIC showed that, for 14 isolates of Candida spp., the @entity2 concentration and the medium composition were the most common factors significantly influencing both control growth yields and the MIC. For eight A. fumigatus isolates, incubation time (24 versus 48 h) and temperature (30 versus 35 degrees C) significantly affected control optical density (OD) values, while growth medium ( @entity4 versus Sabouraud broth) was the most common process variable affecting the MICs. Tests with @entity4 from three suppliers showed significant variations in control OD values related to supplier, but IC(50)s fell within a 2- or 3-dilution range for 19 (86%) of the 22 isolates tested. We recommend that, at present, @entity4 is superior to RPMI 1640 for testing of the susceptibilities of both @entity1 and filamentous fungi to @entity3 and that a minimum incubation time of 48 h is necessary to test A. fumigatus adequately.

title: Influences of methodological variables on susceptibility testing of @entity3 against Candida species and XXXX .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: AT1 receptor blockers (ARB) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight, and onset of type-2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear. EXPERIMENTAL APPROACH: Leptin resistance tests (LRT) in diet-induced obese or lean @entity0 were conducted to determine whether @entity1 (8 mg kg-1 d-1 ,14 days) enhances leptin sensitivity. pSTAT (phosphorylation of signal transducer and activator of transcription 3) staining was performed in hypothalami to estimate leptin transport across the blood-brain barrier. KEY RESULTS: Weight gain, food intake, and plasma leptin were reduced by @entity1 but blood pressure remained unchanged. The 24-h profiles of plasma leptin were similar between controls and @entity1 -treated @entity0 after saline injections, but were higher after leptin injections in controls and slightly lower in @entity1 -treated animals. After @entity1 , energy intake during LRT was lower in leptin- than in saline-pretreated @entity0 , but remained unchanged in controls, irrespectively of whether @entity0 received saline or leptin. Leptin minimized the gain in body weight during LRT in @entity0 treated with @entity1 as compared to saline-treated animals. pSTAT3 staining was reduced in cafeteria diet-fed @entity0 as compared to chow-fed @entity0 but normalized by @entity1 . Hypothalamic mRNA levels of the orexigenic peptides melanin-concentrating hormone and preproorexin were reduced by @entity1 . CONCLUSIONS AND IMPLICATIONS: @entity0 develop leptin resistance due to the cafeteria diet after 2 weeks. Leptin sensitivity is preserved by @entity1 treatment despite feeding with cafeteria diet. This pleiotropic effect is not related to the hypotensive action of @entity1 .

title: Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese XXXX .

answer: @entity0


abstract: The Test of Variables of Attention (T.O.V.A.; R. A. Leark, T. R. Dupuy, L. M. Greenberg, C. L. Corman, _ C. L. Kindeschi, 1996) is a continuous performance test used widely to help diagnose @entity1 ( @entity1 ) in both hearing and deaf @entity0 . The T.O.V.A. previously has been normed only on the hearing population. The T.O.V.A. performance of 38 prelingually and severely-to-profoundly deaf young adults and 34 hearing young adults who did not have @entity1 was examined in this study. Deaf and hearing @entity0 did not differ on the T.O.V.A. omission variables. However, deaf @entity0 had significantly lower d' scores than hearing @entity0 , indicating reduced perceptual sensitivity to the distinction between target and distractor stimuli. Consistent with the existing literature on attentional reorganization in the deaf population, this result was interpreted as indicating a @entity2 -related reduction in attention to centrally presented stimuli. Deaf @entity0 also showed 2 to 3 times more commission errors than hearing @entity0 and displayed a higher incidence of anticipatory errors. These results suggest a @entity2 -related increase in impulsivity at the time of response initiation. Beta score analysis confirmed that deaf @entity0 adopted an overall less conservative (more impulsive) response criterion that contributed to their total elevated commission errors. However, a portion of the commission errors was secondary to their reduced d', not to increased behavioral impulsivity. Separate factor analyses of the standard T.O.V.A. variables revealed highly similar factor structures for deaf and hearing @entity0 , indicating similar construct validity of the T.O.V.A. for both groups. The evidence for increased inattention and impulsivity in a non- @entity1 deaf sample are interpreted in the context of an adaptive attentional reorganization due to @entity2 . Along with the factor analytic results, these considerations suggest that separate T.O.V.A. norms must be developed for the deaf population to avoid overdiagnosis of @entity1 in deaf individuals.

title: Deaf adults without XXXX display reduced perceptual sensitivity and elevated impulsivity on the Test of Variables of Attention (T.O.V.A.).

answer: @entity1


abstract: OBJECTIVES: This paper aims to identify clinical and serological differences, damage accrual and mortality, in juvenile, adult and late-onset @entity7 . METHODS: We conducted our study with @entity0 fulfilling @entity7 classification criteria taken from the Hospital Gregorio Mara  on Autoimmune Systemic @entity6 ' Registry (1986 to 2012). Clinical characteristics, laboratory data and therapies used during the course of the disease were analysed with @entity0 divided into 3 groups: juvenile-onset ( <=18 years), adult-onset (19-50) and late onset (>50 years). RESULTS: Four hundred and forty-five @entity0 were included. @entity2 and cutaneous manifestations were more frequent in the juvenile-onset group at disease onset. During follow-up, juvenile-onset group presented a higher incidence of @entity2 , @entity9 , @entity10 , @entity8 , and @entity4 manifestations than the other two groups. @entity5 and lymphopoenia were more frequent in the adult-onset group. Arterial @entity3 and @entity1 were more frequent in the late-onset group. Low serum complement, anti-dsDNA, anti- @entity11 and anti-Sm antibodies were more common in the juvenile-onset group. @entity0 with late-onset @entity7 had more damage accrual. Thirty-seven @entity0 (8.3%) died during the study. All-cause mortality was significantly higher in the late-onset group. Age at disease onset >50 years was an independent risk factor for damage accrual (OR, 2.2; 95%CI, 1.1-4.6; p=0.029) and mortality (OR, 2.6; 95%CI, 1.1-6.3; p=0.03). CONCLUSIONS: We found significant differences in clinical and serological profiles between juvenile, adult and late-onset @entity7 . The most significant of which was a higher prevalence of @entity2 as well as different autoantibody signatures for the juvenile-onset group.

title: Juvenile, adult and late-onset XXXX : a long term follow-up study from a geographic and ethnically homogeneous population.

answer: @entity7


abstract: This study aimed to test the role of family social support, @entity3 , @entity2 and self-efficacy on specific self-care behaviours. In a local community health center, 318 @entity0 with @entity1 completed a questionnaire assessing self-care, family social support, @entity3 , @entity2 and self-efficacy in 2012. Each self-care behaviour was separately analyzed with logistic regression models. The mean score of perceived family social support for @entity1 treatment was 20.91 (maximum=60). Adult @entity0 were identified as the primary support source. Approximately 22.3% and 15.4% of @entity0 reported symptoms of @entity2 and @entity3 , respectively. @entity0 had moderately positive levels of confidence performing self-care (42.1  13.3 out of 60). After adjusting for demographic and health variables, a 10-unit increase in family social support increased the odds ratio (OR) of taking medication by 1.39 (95% confidence interval (CI) 1.03-1.87) and increased the OR for measuring blood pressure (BP) regularly by 1.33 (95% CI 1.02-1.74). @entity3 and @entity2 were not associated with any self-care behaviours. A10-unit increase in self-efficacy increased the adjusted OR for performing physical exercise to 1.25 (95% CI 1.04-1.49). In conclusion, family social support was positively associated with medication adherence and regular BP measurement. Strategies to improve family social support should be developed for @entity1 control, yet further prospective studies are needed to understand the effects of family social support, @entity3 , @entity2 and self-efficacy on self-care behaviours.Journal of @entity0 @entity1 advance online publication, 10 July 2014; doi:10.1038/jhh.2014.58.

title: The association of family social support, @entity3 , XXXX and self-efficacy with specific @entity1 self-care behaviours in Chinese local community.

answer: @entity2


abstract: OBJECTIVES: Pistachio nut ingestion (3 oz./d, two weeks) was tested for effects on exercise performance and 21-h post-exercise recovery from @entity0 , oxidative stress, @entity2 , and metabolite shifts. METHODS: Using a randomized, crossover approach, cyclists (N=19) engaged in two 75-km time trials after 2-weeks pistachio or no pistachio supplementation, with a 2-week washout period. Subjects came to the lab in an overnight fasted state, and ingested water only or 3 oz. pistachios with water before and during exercise. Blood samples were collected 45 min pre-exercise, and immediately post-, 1.5-h post-, and 21-h post-exercise, and analyzed for plasma cytokines, @entity3 (CRP), @entity5 (F2-IsoP), granulocyte phagocytosis (GPHAG) and oxidative burst activity (GOBA), and shifts in metabolites. RESULTS: Performance time for the 75-km time trial was 4.8% slower under pistachio conditions (2.84  0.11 and 2.71  0.07 h, respectively, P=0.034). Significant time effects were shown for plasma cytokines, CRP, F2-IsoP, GPHAG, and GOBA, with few group differences. Metabolomics analysis revealed 423 detectable compounds of known identity, with significant interaction effects for 19 metabolites, especially @entity4 , (12Z)-9,10-Dihydroxyoctadec-12-enoate ( @entity6 ), and @entity1 . Dietary intake of @entity4 was 2.19  0.15 and 0.35  0.08 mg/d during the pistachio and no pistachio periods, and metabolomics revealed that colon @entity4 and @entity1 translocated to the circulation during exercise due to increased gut permeability. The post-exercise increase in plasma @entity4 correlated significantly with 9,10-DiHOME and other oxidative stress metabolites. CONCLUSIONS: In summary, 2-weeks pistachio nut ingestion was associated with reduced 75-km cycling time trial performance and increased post-exercise plasma levels of @entity4 , @entity1 , and metabolites related to leukotoxic effects and oxidative stress. TRIAL REGISTRATION: ClinicalTrials.gov NCT01821820.

title: Influence of pistachios on performance and exercise-induced XXXX , oxidative stress, @entity2 , and metabolite shifts in cyclists: a randomized, crossover trial.

answer: @entity0


abstract: The basic mechanism of reinforcement in tendons addresses the transfer of stress, generated by the deforming proteoglycan (PG)-rich matrix, to the collagen fibrils. Regulating this mechanism involves the interactions of PGs on the fibril with those in the surrounding matrix and between PGs on adjacent fibrils. This understanding is key to establishing new insights on the biomechanics of tendon in various research domains. However, the experimental designs in many studies often involved long sample preparation time. To minimise biological degradation the tendons are usually stored by freezing. Here, we have investigated the effects of commonly used frozen storage temperatures on the mechanical properties of tendons from the tail of a @entity0 model (C57BL6 @entity0 ). Fresh (unfrozen) and thawed samples, frozen at temperatures of -20  C and -80  C, respectively, were stretched to @entity1 . Freezing at -20  C revealed no effect on the maximum stress (  ), stiffness (E), the corresponding strain (  ) at    and strain energy densities up to    (u) and from    until complete @entity1 (up). On the other hand, freezing at -80  C led to higher   , E and u;    and up were unaffected. The results implicate changes in the long-range order of radially packed collagen molecules in fibrils, resulting in fibril @entity1 at higher stresses, and changes to the composition of extrafibrillar matrix, resulting in an increase in the interaction energy between fibrils via collagen-bound PGs.

title: Effects of frozen storage temperature on the elasticity of tendons from a small XXXX model.

answer: @entity0


abstract: The authors report a series of 46 @entity0 operated for an @entity1 from January 92 to January 96 in H  tel-Dieu de France. There were 28 males and 18 females ranging from 22 to 69 years. Forty-four @entity0 presented a typical clinical pattern of @entity3 . In 20 cases (45%), correct diagnosis was not made at the time of @entity4 but at another outpatient visit or at a @entity4 recurrence. Cerebral angiography was performed in all our @entity0 . The most frequent aneurysmal location was at the anterior communicating artery (n = 20). Surgical total exclusion of the @entity2 was possible in 45 @entity0 . Forty-one @entity0 had a favourable outcome but three presented important neurological sequelae. We encountered 2 postoperative deaths due to irreversible arterial @entity5 . These results suggest that the preoperative neurological state and the occurrence of an arterial @entity5 are the main prognostic factors of the @entity1 . Early diagnosis and treatment allow to avoid rebleeding, mostly responsible of the poor neurological status, and to better manage the arterial @entity5 in order to improve the outcome.

title: [Intracranial arterial XXXX : from diagnosis to treatment. A retrospective study of 46 surgically treated cases].

answer: @entity2


abstract: @entity5 ( @entity5 ) is important in attracting monocytes to sites of @entity1 . Using predominantly pharmacological approaches, prior studies have indicated that @entity3 / @entity4 kinases are involved in the @entity5 -induced signaling pathways. We report here that there is substantial inhibition of @entity5 -stimulated chemotaxis of @entity0 monocytes treated with inhibitors selective for the subset of @entity3 / @entity4 kinases, @entity6 ( @entity6 ). Selective inhibitors of @entity6 such as @entity9 and Calphostin C both caused approximately 80% inhibition of chemotaxis. Because these pharmacological inhibitors do not specifically inhibit individual @entity6 isoforms, we chose to use antisense oligodeoxyribonucleotides (ODN) to specifically reduce @entity6 isoform expression, first by inhibiting expression of the conventional @entity6 family, and next by using specific antisense ODN for @entity8 and @entity10 . Conventional @entity6 -antisense ODN treatment completely and significantly inhibited monocyte chemotaxis to @entity5 , whereas sense-control ODN caused no significant inhibition. @entity10 -antisense ODN caused 89.2% inhibition of chemotaxis at its highest dose. In contrast, @entity10 -sense ODN and @entity8 -antisense and -sense ODN were without effect. Further studies evaluating the @entity2 response that is triggered upon @entity5 interaction with its receptor, @entity7 , indicate that this response is not altered by antisense or sense ODN treatment, thus supporting our hypothesis that @entity10 is critical for post-receptor signal transduction downstream of the immediate @entity2 signal. These data contribute to our developing understanding of the signal transduction pathways involved in the chemotactic response of @entity0 monocytes to @entity5 and uniquely identify the requirement for the @entity10 isoform in this important process.

title: @entity10 is required for @entity0 monocyte chemotaxis to XXXX .

answer: @entity5


abstract: [Purpose] The present study aimed to find out the @entity3 prevalence 11-15 years old @entity0 and to create awareness about @entity3 . [Subjects and Methods] All of the @entity0 were assessed using the Adams Forward Bendings Test and a scoliometer. Sagittal plane changes such as @entity1 , @entity2 , hypokyphosis, hypolordosis and anterior head tilt were screened. @entity0 with trunk rotation angles ( @entity5 ) of 4 degrees or more were suspected of having @entity3 , and were evaluated for a second time for gibbosity height, arm-trunk distance, and @entity5 . [Results] A total of 2,207 @entity0 were screened and the evaluation revealed there were 11 @entity0 (0.49%) with a Cobb angle of 10 degrees and more. The maximum Cobb angle was 43   (right thoracic-left lumbar) and the maximum @entity5 was 12  . Two @entity0 had @entity1 and @entity2 , and one had hypokyphosis and was diagnosed as having @entity4 . [Conclusion] Families should regularly check their @entity0 , even if they are not diagnosed as having @entity3 in school screenings. It is our opinion that our study increased the awareness of the families about @entity3 by screening, brochures and posters. In the future, if school screenings were performed as a routine procedure and scoliotic students were followed over the long term, the actual effectiveness of screening would be able to be detected.

title: XXXX screening results of primary school students (11-15 years old group) in the west side of Istanbul.

answer: @entity3


abstract: BACKGROUND: Pregnancy-related @entity12 may lead to @entity4 . Although this @entity5 had virtually disappeared in high-income countries, we have noted new cases in France over the past few years, all following postpartum @entity6 . STUDY DESIGN: Case series. SETTING _ @entity0 : We retrospectively identified 18 @entity0 from 5 French nephrology departments who developed @entity12 following postpartum @entity6 in 2009 to  2013. OUTCOMES: Obstetric and renal features, therapeutic measures, and @entity1 outcome were studied. RESULTS: All @entity0 had a severe postpartum @entity6 (mean @entity3 , 2.6  1.1 [SD] L). @entity10 and disseminated @entity11 were reported in 5 and 11 @entity0 , respectively. All developed rapid onset of @entity7 and required hemodialysis. Diagnosis of @entity12 was performed 4 to 33 days following delivery. At 6 months postpartum, 8 @entity0 remained dialysis dependent and none recovered normal kidney function. The length of exposure to @entity8 treatment was significantly more prolonged in @entity0 whose estimated glomerular filtration rate remained  <15mL/ @entity9 .73m(2) (7.1  4.8 vs 2.9  2.4 hours; P=0.03). LIMITATIONS: Retrospective study; small sample size. CONCLUSIONS: In the setting of gravid endothelium, the conjunction of disseminated @entity11 with the life-saving use of procoagulant and antifibrinolytic agents (recently implemented in France in a postpartum @entity6 treatment algorithm) may give rise to a risk for uncontrolled clotting in the renal cortex and hence irreversible partial or diffuse cortical @entity2 .

title: XXXX in Postpartum @entity6 : A Case Series.

answer: @entity12


abstract: The aim of this study was to describe @entity1 disposition in a pediatric population who underwent bone marrow transplantation (BMT). @entity1 administered dose was 1 mg/kg every 6 h for 4 days. Plasma determinations were performed after the first dosing at 0, 15, 30, 60, 90, 120, 180, 240, 300, and 360 min. A noncompartment analysis model for extravascular absorption was used for the pharmacokinetic analysis. To obtain the area under the concentration-time curve (AUC) within the "therapeutic window" of 1,000-1,200 microM x minutes a @entity1 dose adjustment Was performed at the fourth dose. Forty-five @entity1 pharmacokinetic analyses were performed in 34 @entity0 . Eleven @entity0 had their dose adjusted [1.19 +/- 0.14) mg/kg] at the fourth dose and the AUC was monitored at the fifth one. The mean AUC +/- SD after the fifth dose (998.1 +/- 189.2 microM x min) was different (p = .006)from that after the first dose (1 mg/kg) (687.63 +/- 166.43 microM x min). Six @entity0 had their first AUC into the "therapeutic window," 17 @entity0 had their dose adjusted [1.2 (+/- 0.22) mg/kg], but the "adjusted" AUC was not available. These data suggest that it may be reasonable to recommend a @entity1 dose of 1.2 mg/kg to achieve the accepted therapeutic target in @entity0 undergoing BMT.

title: Therapeutic monitoring of XXXX in pediatric bone marrow transplantation.

answer: @entity1


abstract: BACKGROUND: Male factor abnormality is the cause of @entity1 in about 20%-40% of infertile couples. Assisted reproduction with intracytoplasmic sperm injection is the only treatment option for severe forms of andrological @entity1 . METHODS: We retrospectively analysed @entity0 who had had intracytoplasmic sperm injection for male factor @entity1 . The clinical and laboratory factors that influenced the pregnancy rate were also analysed. RESULTS: One hundred and seventy-five cycles in 164 couples were analysed. The fertilization, cleavage and pregnancy rates were similar in the groups that had had intracytoplasmic sperm injection with epididymal, testicular or ejaculate sperm. Univariate analysis of the clinical variables showed progressive reduction in pregnancy rate with increase in the @entity0 partner's age and body mass index, and presence of pelvic disease, but these were not statistically significant. The age of the @entity0 was the most significant factor affecting the pregnancy rate after adjusting for body mass index and pelvic disease in the multivariate analysis (OR 0.26, 95% CI: 0.08-0.84, p=0.03). The oocyte number, embryo transfer number and transfer day had no significant influence on the outcome. CONCLUSION: The @entity0 partner's age influences the success of assisted reproduction with intracytoplasmic sperm injection in male factor @entity1 . Thus, the chances of success are better if the couple seeks treatment at an early age.

title: Factors predicting the outcome of intracytoplasmic sperm injection for XXXX .

answer: @entity1


abstract: UNASSIGNED: 140 Background: Eribulin mesylate, a nontaxane microtubule dynamics inhibitor, has demonstrated an overall survival benefit relative to other commonly used agents in @entity1 (pts) with at least 2 prior MBC cytotoxic therapies. Primary data presented from 2 phase 2 trials, Study 206 (eribulin in @entity2 - @entity0 pts) and Study 208 (combination eribulin + trastuzumab [TRAS] in @entity2 + @entity0 pts), showed clinical activity and acceptable tolerability profiles as first-line cytotoxic therapy (tx). Here we present prespecified efficacy data for both trials based on prior @entity4 (A) and @entity3 (T) use. METHODS: In both studies, pts received eribulin mesylate 1.4 mg/m(2) IV on days 1 and 8 of each 21-day cycle. Pts in Study 208 ( @entity2 +) also received initial TRAS (8 mg/kg IV/Day 1), followed by 6 mg/kg/day 1 of each subsequent cycle. Objective response rate (ORR), progression-free survival (PFS), and tolerability were assessed. RESULTS: In Study 206 (N=56), 48% and 46% received prior A and T, and in Study 208 (N=52), 21% and 44% received prior A and T, respectively. ORR, the primary endpoint, was similar in pts, regardless of prior A or T, except in pts w/o prior T in Study 208 whose ORR trended higher (table). Clinical benefit rate (CBR), PFS, and duration of response (DOR) were either similar or trended higher in pts w/o prior A or T. PFS was higher in @entity2 + @entity0 @entity1 receiving @entity5 + TRAS who had not received prior A or T compared with those who had. Grade (G) 3-5 adverse event rates were similar or lower in pts who had not received prior A or T. CONCLUSIONS: As first-line therapy, eribulin in @entity2 - @entity0 pts and eribulin + TRAS in @entity2 + @entity0 pts were effective and well tolerated, regardless of prior A or T tx. However, in @entity2 + @entity0 pts receiving eribulin + TRAS, the lack of prior A or T tx may be a lead to longer median PFS. CLINICAL TRIAL INFORMATION: NCT01268150/NCT01269346. [Table: see text].

title: Clinical effects of prior @entity4 or @entity3 use on eribulin as first-line treatment for HER+/- locally recurrent or metastatic @entity0 ( XXXX ): Results from 2 phase 2, multicenter, single-arm studies.

answer: @entity0


abstract: BACKGROUND AND AIM: @entity6 (PG) E2 promotes @entity3 and @entity1 progression. The total amount of biologically active @entity5 in tissues is determined by a balance of PG biosynthesis and degradation pathways, which involve the PG transporter (PGT). We investigated PGT in @entity4 by determining its expression pattern and examining associations of PGT with prognosis and @entity1 angiogenesis. METHODS: PGT expression was determined by immunohistochemistry in advanced @entity4 specimens obtained from 96 @entity0 who underwent surgical resection. Correlations between PGT expression level and clinicopathological factors were statistically analyzed. Angiogenesis in the @entity1 tissue was evaluated by counting the number of microvessels. The role of PGT in mRNA and protein expression of @entity2 ( @entity2 ) was examined in @entity4 cells stimulated by @entity5 . RESULTS: Based on multivariate and Kaplan-Meier analyses, negativity for PGT expression was an independent poor prognostic factor. There were more microvessels in PGT-negative @entity1 than in PGT-positive @entity1 . Transfection of @entity7 and MKN7 @entity4 cells with PGT-specific siRNA led to increased @entity2 mRNA and protein expression accompanied by increased @entity5 in the culture media. CONCLUSIONS: PGT expression is an independent predictor of poor survival and is associated with @entity1 angiogenesis in @entity4 .

title: Reduction of XXXX transporter predicts poor prognosis associated with angiogenesis in @entity4 .

answer: @entity6