abstract: We compared the efficacy of @entity6 , @entity4 , @entity2 , and @entity5 in minimizing @entity1 caused by the injection of @entity3 in 250 @entity0 . After tourniquet application on the forearm, the @entity0 were given saline (3 mL) (Group 1, n = 50), @entity6 (4 mg) (Group 2, n = 50), @entity4 (30 mg) (Group 3, n = 50), @entity2 (50 mg) (Group 4, n = 50), or @entity5 (100 microg) (Group 5, n = 50) diluted into a 3-mL solution. The occlusion was released after 20 s and @entity3 was injected over 10-15 s. The @entity0 were observed and asked immediately if they had @entity1 in the arm, and the response was assessed. Reactions such as discomfort and @entity1 , withdrawal of the hand, and so on after the administration of @entity3 were recorded as side effects for 24 h. Ten @entity0 in Group 1, 28 @entity0 in Group 2, 37 @entity0 in Group 3, 30 @entity0 in Group 4, and 15 @entity0 in Group 5 reported no @entity1 . Light @entity1 was seen in 11 @entity0 in Group 1, 14 @entity0 in Group 2, 11 @entity0 in Group 3, 12 @entity0 in Group 4, and 20 @entity0 in Group 5. Moderate @entity1 was seen in 15 @entity0 in Group 1, 6 @entity0 in Group 2, 2 @entity0 in Group 3, 8 @entity0 in Group 4, and 10 @entity0 in Group 5. Severe @entity1 was seen in 14 @entity0 in Group 1, 2 @entity0 in Group 2, 0 @entity0 in Group 3, 0 @entity0 in Group 4, and 5 @entity0 in Group 5. Correlation determined with log-linear analysis found in Group 1 @entity1 score 0 (P < 0.001), Group 1 @entity1 score 1 (P < 0.001), and Group 3 @entity1 score 0 (P < 0.001). We conclude that @entity6 , @entity4 , @entity2 , and @entity5 decrease the level of @entity3 injection @entity1 . Among these drugs, @entity4 is the most effective, whereas @entity5 is the least effective. IMPLICATIONS: We compared the efficacy of @entity6 , @entity4 , @entity2 , and @entity5 in minimizing the @entity1 on injection of @entity3 in 250 @entity0 . @entity6 , @entity4 , @entity2 , and @entity5 were effective in preventing and decreasing the level of @entity3 injection @entity1 . Among these drugs, @entity4 was the most effective, and @entity5 was the least effective.

title: The prevention of @entity1 from injection of @entity3 by XXXX , @entity4 , @entity2 , and @entity5 .

answer: @entity6


abstract: @entity1 @entity0 have a markedly increased risk of @entity3 compared with non-diabetics. Two drug groups today target insulin resistance; @entity17 and @entity16 . In addition, these may have other effects on cardiovascular risk factors. The aim of this study was to evaluate the effects of @entity11 and @entity15 on non-traditional cardiovascular risk factors. Forty @entity4 2 @entity1 @entity0 were randomized into @entity11 and @entity15 groups. After receiving the optimal doses, the @entity0 were monitored for 12  weeks. Biochemical parameters, lipid parameters, @entity12 , and HbA1c levels were analyzed. @entity13 , @entity10 , @entity9 , @entity5 , @entity7 , @entity14 , and fibrinogen levels were measured in order to assess coagulation status and @entity6 . In the @entity11 group, body mass index, @entity8 , HbA1c, @entity7 , @entity9 , and @entity5 levels were significantly decreased after 12  weeks compared with the basal levels. @entity7 levels decreased from 75  pg/ml      20 to 42  pg/ml      9 (P 0.023) and @entity5 levels from 61  pg/ml      31 to 39  pg/ml      10 (P 0.018). In the @entity15 group, FPG, @entity8 , HbA1c, insulin, HOMA-IR, @entity7 , and @entity5 levels decreased significantly after 12  weeks compared with the basal levels. @entity7 levels decreased from 78  pg/ml      21 to 41  pg/ml      9 (P 0.028) and @entity5 levels from 62  pg/ml      19 to 37  pg/ml      10 (P 0.012). At the end of the study, no significant differences were determined between groups. Insulin resistance and @entity4 2 @entity1 are strongly associated with low grade @entity2 . Both @entity11 and @entity15 were effective in controlling inflammatory markers in addition to metabolic parameters.

title: The effects of XXXX and @entity11 on @entity2 and @entity6 in @entity0 with @entity1 .

answer: @entity15


abstract: OBJECTIVES: This study compared diagnostic accuracy of conventional troponin/traditional @entity2 ( @entity2 ) assessment and highly sensitive troponin (hsTn) I/advanced @entity2 assessment for @entity6 ( @entity6 ) during the index hospitalization. BACKGROUND: hsTnI and advanced assessment of @entity2 using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of @entity0 with suspected @entity6 . METHODS: We performed an observational cohort study in @entity0 with suspected @entity6 enrolled in the ROMICAT II (Rule Out @entity4 / @entity1 using Computer Assisted Tomography) trial and randomized to coronary CTA who also had hsTnI measurement at the time of the emergency department presentation. We assessed coronary CTA for traditional (no @entity2 , nonobstructive @entity2 ,  >= 50% @entity5 ) and advanced features of @entity2 (>= 50% @entity5 , high-risk plaque features: positive remodeling, low  <30-Hounsfield units plaque, napkin-ring sign, spotty @entity3 ). RESULTS: Of 160 @entity0 (mean age: 53    8 years, 40% @entity0 ) 10.6% were diagnosed with @entity6 . The @entity6 rate in @entity0 with hsTnI below the limit of detection (n  = 9, 5.6%), intermediate (n  = 139, 86.9%), and above the 99(th) percentile (n  = 12, 7.5%) was 0%, 8.6%, and 58.3%, respectively. Absence of  >= 50% @entity5 and high-risk plaque ruled out @entity6 in @entity0 with intermediate hsTnI (n  = 87, 54.4%; @entity6 rate 0%), whereas @entity0 with both  >= 50% @entity5 and high-risk plaque were at high risk (n  = 13, 8.1%; @entity6 rate 69.2%) and @entity0 with either  >= 50% @entity5 or high-risk plaque were at intermediate risk for @entity6 (n  = 39, 24.4%; @entity6 rate 7.7%). hsTnI/advanced coronary CTA assessment significantly improved the diagnostic accuracy for @entity6 as compared to conventional troponin/traditional coronary CTA (area under the curve 0.84, 95% confidence interval [CI] 0.80 to .88 vs. 0.74, 95%CI 0.70 to 0.78; p  < 0.001). CONCLUSIONS: hsTnI at the time of presentation followed by early advanced coronary CTA assessment improves the risk stratification and diagnostic accuracy for @entity6 as compared to conventional troponin and traditional coronary CTA assessment. (Multicenter Study to Rule Out @entity4 / @entity1 by Cardiac Computed Tomography [ROMICAT-II]; NCT01084239).

title: hs-Troponin I Followed by CT Angiography Improves Acute Coronary Syndrome Risk Stratification Accuracy and Work-Up in Acute Chest Pain XXXX : Results From ROMICAT II Trial.

answer: @entity0


abstract: Cytogenetic and molecular studies of azoospermic and oligozoospermic males have suggested the presence of @entity2 factors (AZF) in the @entity0 Y chromosome. Deletion in three Y chromosomal regions--AZFa, AZFb and AZFc--has been reported to disrupt spermatogenesis and cause @entity1 . Several candidate genes responsible for spermatogenesis have been identified in these regions and some of them are thought to be functional in @entity0 spermatogenesis. Here we report on clinical and molecular studies of Y chromosome micro-deletions in Japanese. In these studies the data from 157 @entity1 Japanese @entity0 with @entity2 and @entity3 was analyzed and divided into 5 categories based on spermatozoa count. Sixteen sets of primers were used for polymerase chain reaction (PCR) to amplify sequence tagged site markers. One common deletion in the AZFc region was identified in @entity1 @entity0 . On the other hand, no deletions around the AZFc region were identified in fertile @entity0 . Japanese @entity1 @entity0 in our study had a common deletion in the AZFc region of the Y chromosome. A genomic clone was obtained by PCR screening of the P1 phage artificial chromosome (PAC) library. This clone was analyzed by Southern blotting using a PCR amplified probe of sY240. Our analysis of the genomic sequence of the clone suggests that this locus may contain specific genes for spermatogenesis.

title: Molecular analysis of the Y chromosome AZFc region in Japanese XXXX males with spermatogenic defects.

answer: @entity1


abstract: BACKGROUND: Effective treatment for @entity0 with acute @entity2 is limited by @entity0 delay in seeking care. Inadequate knowledge of @entity1 may prolong delay. An intervention designed to reduce delay was tested in the Rapid Early Action for Coronary Treatment (REACT) Community Trial. In this report, the impact on knowledge of @entity1 is presented. METHODS: Twenty communities were randomized to intervention or comparison status in a matched-pair design. Intervention strategies included community organization, public education, professional education, and @entity0 education. The main outcome measures were based on information regarding knowledge of symptoms collected in a series of four random-digit-dialed telephone surveys. RESULTS: Knowledge of REACT-targeted symptoms increased in intervention communities. No change was observed in comparison communities. The net effect was an increase of 0.44 REACT-targeted symptoms per individual (P<0.001). The intervention effect was greater in ethnic minorities, @entity0 with lower household incomes, and those with family or spouse history of @entity1 (P<0.05). CONCLUSIONS: The REACT intervention was modestly successful in increasing the general public's knowledge of the complex constellation of @entity1 . The intervention program was somewhat more effective in reaching disadvantaged subgroups, including ethnic minorities and @entity0 with lower income. Despite these successes, the post-intervention level of knowledge was suboptimal.

title: Knowledge of XXXX in 20 US communities. Results from the Rapid Early Action for Coronary Treatment Community Trial.

answer: @entity1


abstract: BACKGROUND: Although systemic endothelial function is unimpaired in @entity6 , it is unknown whether cerebral endothelial function impairment exists in migraineurs. MATERIALS AND METHODS: We conducted a prospective study to assess endothelial function in migraineurs (n=45) and healthy volunteers (n=44). Cerebral endothelial function was assessed by Breath Holding Index (BHI) on transcranial Doppler in bilateral middle cerebral artery (MCA at 30-60   mm), posterior cerebral artery (PCA at 60-80   mm) and basilar artery (BA at 80-120   mm) using bilateral monitoring probes fixed on headband. Brachial artery @entity4 ( @entity4 ) was used as measure of systemic endothelial function. RESULTS: There was no difference in baseline mean velocities of MCA, PCA, BA among migraineurs and controls. Mean BHI was significantly lower in PCA (p<0.001) and BA (p<0.001) in @entity0 with @entity6 with no difference in MCA (p=0.909, 0.450). @entity3 (BHI<1.15) was present in 62.2% of migraineurs in the right PCA (p<0.001), 57.8% in left PCA (p<0.001) and 77.8% in BA (BHI <0.83, p<0.001). There was no difference in BHI among migraineurs without and with aura (n=15). Cerebral and systemic endothelial function had no correlation in migraineurs. Increasing BMI was identified as a predictor of impaired BHI in the BA in migraineurs (p=0.020). Age, sex, presence of aura, lateralisation of @entity1 , @entity1 frequency, time to last attack and impaired @entity4 were not associated with @entity2 and BA BHI in migraineurs. CONCLUSIONS: Migraineurs may have @entity3 restricted to the posterior circulation in the absence of systemic @entity5 .

title: Interictal cerebral and systemic XXXX in @entity0 with @entity6 : a case-control study.

answer: @entity5


abstract: BACKGROUND: Aniseed is a spice frequently used in Mediterranean cooking and, as with other Umbelliferae, it has been involved in clinical @entity2 . OBJECTIVE: This investigation was undertaken to study the allergens implicated in a case of occupational @entity2 to aniseed associated with @entity6 and @entity1 . METHODS: Skin prick tests were performed to inhalant allergens, spices used in the @entity0 's workplace (aniseed and cinnamon), and 12 other Umbelliferae spices, birch, and mugwort. A nasal challenge test to aniseed and cinnamon and a double-blind placebo-controlled oral food challenge test to aniseed were also performed. The molecular weights of the allergens were studied by @entity4 - @entity3 gel electrophoresis immunoblotting and cross-reactivity among Umbelliferae species by enzyme immunoassay inhibition. RESULTS: Skin prick tests showed a positive immediate response to aniseed, asparagus, caraway, coriander, cumin, dill, and fennel extracts, and an intense late response to aniseed. Skin prick tests to celery, @entity7 , birch pollen, and mugwort pollen extracts were negative. Results of a nasal challenge test were positive to aniseed and negative to cinnamon; an aniseed oral food challenge test yielded a positive response. The molecular weights of the main immunoglobulin (Ig)E-binding proteins in aniseed extracts were approximately 48, 42, 39, 37, 34, 33, and 20 kD. Caraway, fennel, cumin, and coriander extracts showed similar IgE-binding patterns. Enzyme immunoassay inhibition studies with the patient's serum revealed cross-reactivity among the IgE components from aniseed, caraway, coriander, fennel, and dill extracts. CONCLUSIONS: We demonstrate the presence of aniseed allergens in a case of occupational @entity6 and @entity5 , with molecular weights for this spice that differed from those previously reported.

title: Occupational @entity6 and XXXX because of aniseed sensitization.

answer: @entity5


abstract: PURPOSE: To investigate the morphological and biochemical effects of @entity5 associated with @entity2 on @entity1 throughout the pregnancy of albino @entity0 . MATERIALS AND METHODS: Forty pregnant @entity0 were divided into four numerically equal groups: control (C), experiment 1 (E1), experiment 2 (E2), and experiment 3 (E3). Only distilled water was given to the control group, while groups E1, E2, and E3 received, respectively, 5, 15 and 45 mg/kg of @entity5 associated with 20, 60, and 180 mg/kg of @entity2 , per day, throughout the pregnancy. On the 20th day of the pregnancy, the histological structure of the @entity1 was analyzed by means of optical microscopy, along with the blood concentrations of AST, ALT, @entity4 , and matrix @entity3 . The numerical variables were analyzed using the Kruskal-Wallis test and Dunn's multiple comparison test. RESULTS: The histological alterations occurred in both the maternal livers and the maternal kidneys, particularly in group E3, which received the greatest therapeutic dosage (nine times). The blood levels ofALT in group E3 were significantly lower than in the other groups (p = 0.0037). The @entity4 and @entity3 levels in the blood were significantly lower in group E1 (p = 0.0420 andp = 0.0108, respectively). CONCLUSIONS: rhe association of @entity5 and @entity2 affected the histological structure of the kidneys of the matrices of group E3. There was a significant decrease in the blood values of @entity4 e @entity3 in group El.

title: Chronic action of @entity5 and XXXX on maternal and fetal liver and kidney of albino pregnant @entity0 ( @entity0 albinus, Rodentia, Mammalia): morphological and biochemical aspects.

answer: @entity2


abstract: Radionuclide procedures frequently are performed as part of the diagnostic workup of @entity4 . Bone scintigraphy accurately diagnoses @entity4 in bones not affected by underlying conditions. @entity2 , @entity1 , and orthopedic hardware decrease the specificity of the bone scan, making it less useful in these situations. Gallium-67 scintigraphy was often used as an adjunct to bone scintigraphy for diagnosing @entity4 . However, now it is used primarily for @entity3 when (18)F-FDG imaging cannot be performed. Except for the spine, in vitro-labeled leukocyte imaging is the nuclear medicine test of choice for diagnosing complicating @entity4 . Leukocytes accumulate in bone marrow as well as in @entity3 . Performing complementary bone marrow imaging with (99m)Tc-sulfur colloid facilitates the differentiation between @entity4 and normal marrow and improves test overall accuracy. Antigranulocyte antibodies and antibody fragments, such as (99m)Tc-besilesomab and (99m)Tc-sulesomab, were developed to eliminate the disadvantages associated with in vitro-labeled leukocytes. These agents, however, have their own shortcomings and are not widely available. As biotin is used as a growth factor by certain bacteria, (111)In-biotin is useful to diagnose @entity3 . Radiolabeled synthetic fragments of ubiquicidin, a naturally occurring human antimicrobial peptide that targets bacteria, can differentiate @entity3 from sterile inflammation and may be useful to monitor response to treatment. (18)F-FDG is extremely useful in the diagnostic workup of @entity4 . Sensitivity in excess of 95% and specificity ranging from 75%-99% have been reported. (18)F-FDG is the radionuclide test of choice for @entity3 . The test is sensitive, with a high negative predictive value, and reliably differentiates @entity2 . Data on the accuracy of (18)F-FDG for diagnosing @entity0 are contradictory, and its role for this indication remains to be determined. Initial investigations suggested that (18)F-FDG accurately diagnoses @entity3 ; more recent data indicate that it cannot differentiate @entity3 from other causes of prosthetic failure. Preliminary data on the PET agents gallium-68 and iodine-124 fialuridine indicate that these agents may have a role in diagnosing @entity4 .

title: Radionuclide Imaging of XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate the relationship between @entity4 and presence of @entity5 . STUDY DESIGN: A cross-sectional study. METHODS: We included 20 @entity0 with @entity5 and 31 control subjects. A diagnosis of @entity4 and @entity2 was made if the Reflux Symptom Index score was >= 13 and if the Frequency Scale for the Symptoms of @entity2 was >= 8, respectively. We compared the prevalence of the two @entity2 , frequent @entity1 , and demographic factors between the two groups. RESULTS: There was no significant difference in demographic factors between the two groups. Five (25%) of 20 @entity0 with @entity5 had a Reflux Symptom Index >= 13 compared with one (3.2%) of 31 controls. Seven (35.0%) of 20 @entity0 had a Frequency Scale for the Symptoms of @entity2 >= 8 compared with three (9.7%) of 31 controls. A comparison of the prevalence of @entity4 and @entity2 showed a significant difference between @entity0 with @entity3 and controls (P value   =   0.029 and 0.036, respectively). In Reflux Symptom Index, heartburn, hoarseness, and a swallowing problem were significantly frequent symptoms in the @entity3 group compared with the control group. CONCLUSIONS: The prevalence of @entity4 and @entity2 was significantly higher in @entity0 with @entity5 than in controls. Therefore, otolaryngologists and orthopedic surgeons should be aware that @entity0 with @entity5 are likely to have @entity2 and also @entity4 .

title: High Prevalence of XXXX in @entity0 With @entity5 .

answer: @entity4


abstract: UNASSIGNED: Background @entity4 agonists ( @entity3 RA) added to insulin in type 2 @entity1 @entity0 have shown to lower body weight, improve glycaemic control and reduce total daily insulin dose in short term studies, although the individual response greatly varies. Objective To evaluate @entity3 RA treatment on body weight, glycaemic control and total daily insulin dose in @entity2 , insulin-using type 2 @entity1 @entity0 after 2  years follow-up in a real life setting and to explore a possible relation with eating behaviour. Setting The Martini Hospital and the University Medical Center in Groningen in the Netherlands. Methods Eligible @entity0 were at least 18  years of age, were on insulin therapy and @entity2 (BMI  >  30  kg/m(2)), started @entity3 RA treatment. At baseline eating behaviour was classified according to the validated Dutch Eating Behaviour Questionnaire. A 2  years follow-up was performed. Main outcome measures Body weight, HbA1c and total daily insulin dose. Results 151 @entity0 started with exenatide or liraglutide. 120 @entity0 completed the 2  years follow-up. From baseline to 2  years, body weight (mean      SD) changed from 117.9      22.1 to 107.9      22.9  kg (P  <  0.0001), HbA1c (median, IQR) changed from 7.9 (7.2-8.9) to 7.6 (6.9-8.3)  % [63 (55-74) to 60 (52-67)  mmol/mol] (P  <  0.0001), total daily insulin dose changed from 90 (56-150) to 60 (0-100)  Units/day (P  <  0.0001). Weight change differed between eating behaviour groups (P  <  0.001) in which external eating behaviour (n  =  17) resulted in the smallest decline (-3.1  %) and restrained (n  =  41) in the greatest (-10.3  %) in comparison with emotional (n  =  37, -8.5  %) and indifferent (n  =  25, -9.6  %) eating behaviours. Conclusion Two year of @entity3 RA treatment resulted in a sustained reduction of weight, HbA1c and total daily insulin dose in @entity2 , insulin-using type 2 @entity1 @entity0 in a real life setting. Largest weight loss was achieved in @entity0 with a predominant restraint eating pattern while a predominant external eating pattern resulted in the smallest weight reduction.

title: The effects of @entity3 analogues in @entity2 , insulin-using type 2 XXXX in relation to eating behaviour.

answer: @entity1


abstract: Because information regarding @entity9 ( @entity9 ) cellular response in @entity1 ( @entity1 ) is inconclusive, we conducted the following investigation. Cell counts were performed in @entity9 obtained within 24 h of onset of symptoms in 118 adult @entity0 86 years or younger with uncomplicated @entity1 , after @entity6 and mass effect were ruled out by computed tomography. In 98, @entity9 examination was repeated on day 7. None of the @entity0 had evidence for @entity2 , inflammatory disease, @entity8 , @entity5 , @entity4 or @entity7 . @entity9 pleocytosis was defined as white blood cell (WBC) count of five or more mononuclear leukocytes (MNLs) and/or one or more polymorphonuclear leukocytes per cubic milliliter. No cells were found in 78 (66.1%) @entity0 , 25 (21.2%) had one to four MNLs, and 15 (12.7%) had pleocytosis; none had hypoglycorrhachia. Nine @entity0 had @entity10 (LP); in five of them, pleocytosis persisted after correction for red blood cell count. The highest WBC count was 15 cells per cubic milliliter. Only two @entity0 had @entity9 pleocytosis on day 7; both had had traumatic LP and pleocytosis acutely. We found no correlation between @entity9 pleocytosis and cardiac source of embolus or type of @entity3 . From our data, we conclude that in uncomplicated @entity1 , @entity9 pleocytosis is rare and, when present, is mild; it has no correlation with type of @entity1 and is of no diagnostic value.

title: Cerebrospinal fluid cellular response in uncomplicated XXXX .

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) is the leading occupational @entity1 in the area of S  o Paulo Municipality. Understanding its characteristics can provide useful information for better interventions. METHODS: From a joint registry of @entity2 from five outpatient public clinics for occupational @entity1 , data on occupation, with job titles corrected by an expert evaluation, agents, exposure and symptom duration, and spirometry were analyzed by gender. Data on employment for S  o Paulo Municipality were used to calculate expected ratios for @entity0 / @entity0 in broad economical sectors. RESULTS: Three hundred and ninety four @entity2 cases were reported with a ratio of @entity0 / @entity0 of 1.5. @entity0 had significantly shorter exposure duration (5.6 +/- 5.2 vs. 8.9 +/- 9.0 years, P = 0.0005), shorter symptoms duration (2.6 +/- 3.7 vs. 3.2 +/- 3.5 years, P = 0.1270), and higher prevalence of previous atopy (27.0 vs. 18.4%, P = 0.0485). The main occupations related to @entity2 cases were cleaning activities, working in plastics manufacture and in chemical and pharmaceutical plants. @entity0 reported significantly more exposures to cleaning products, biologic agents, and textile fibers, whereas @entity0 reported more exposures to @entity3 , metal dusts and fumes, oil mists, wood dusts and anhydrides. @entity0 presented an increased risk of @entity2 in the service sector (odds ratio (OR) = 1.77, confidence interval (CI) = 1.61-1.96). CONCLUSIONS: Cleaning services was the main reported occupation and cleaning products the main reported agents. @entity0 had significantly shorter exposure duration possibly due to difference in exposures, previous atopy, and behavior. There was an excess of cases of @entity0 in the service sector.

title: XXXX in the city of S  o Paulo, 1995-2000, with special reference to gender analysis.

answer: @entity2


abstract: @entity4 ) infection is a necessary, although not sufficient cause of @entity1 . Globally, @entity5 accounts for an estimated 530,000 @entity1 cases (~270,000 @entity3 ) annually, with the majority (86% of cases, 88% of @entity3 ) occurring in developing countries. Approximately 90% of @entity1 and a smaller subset (<50%) of other @entity1 (oropharyngeal, penile, vaginal, vulvar) are also attributed to HPV. In total, HPV accounts for 5.2% of the worldwide @entity1 burden. HPVs 16 and 18 are responsible for 70% of @entity1 cases and, especially @entity6 , for a large proportion of other @entity1 . Prophylactic vaccination targeting these genotypes is therefore expected to have a major impact on the burden of @entity1 as well as that of other @entity1 . Over the past 50 years, organized or opportunistic screening with Papanicolaou (Pap) cytology has led to major @entity1 in most developed countries. However, due to lack of resources or inadequate infrastructure, many countries have failed to reduce @entity1 mortality through screening. HPV DNA testing recently emerged as a likely candidate to replace Pap cytology for primary screening. It is less prone to @entity0 error and more sensitive than Pap in detecting high-grade @entity2 . For countries with national vaccination programs, HPV testing may also serve as a low cost strategy to monitor long term vaccine efficacy. Introduction of well organized vaccination and screening programs should be a priority for all countries. Increased support from donors is needed to support this cause.

title: Epidemiology and burden of XXXX and related diseases: implications for prevention strategies.

answer: @entity5


abstract: INTRODUCTION: @entity8 ( @entity8 ) and @entity7 ( @entity7 ) are atypical @entity10 with @entity1 as common features. While @entity9 are a good predictor of Lewy body pathology and are rare in @entity7 , they are not exhibited in all cases of @entity8 . Given the clinical overlap between these disorders, neuropsychological and imaging markers may aid in distinguishing these entities. METHODS: Prospectively recruited case-control cohorts of @entity7 (n =31) and @entity3 (n =30), completed neuropsychological and neuropsychiatric measures as well as brain perfusion single-photon emission computed tomography and structural magnetic resonance imaging (MRI). Perfusion data were available for forty-two controls. Behavioural, perfusion, and cortical volume and thickness measures were compared between the groups to identify features that serve to differentiate them. RESULTS: The Lewy body with no hallucinations group performed more poorly on measures of episodic memory compared to the corticobasal group, including the delayed and cued recall portions of the California Verbal Learning Test (F (1, 42) =23.1, P <0.001 and F (1, 42) =14.0, P =0.001 respectively) and the delayed visual reproduction of the Wechsler Memory Scale-Revised (F (1, 36) =9.7, P =0.004). The Lewy body group also demonstrated reduced perfusion in the left occipital pole compared to the corticobasal group (F (1,57) =7.4, P =0.009). At autopsy, the Lewy body cases all demonstrated @entity4 with @entity8 , @entity2 , while the corticobasal cases demonstrated classical @entity5 in five, @entity4 with agyrophilic grains   +   @entity5   +   @entity12 in one, @entity11 in two, and Frontotemporal Lobar Degeneration-Ubiquitin/ @entity6 @entity13 in one. MRI measures were not significantly different between the @entity0 groups. CONCLUSIONS: Reduced perfusion in the left occipital region and worse episodic memory performance may help to distinguish between @entity8 cases who have never manifested with @entity9 and @entity7 at earlier stages of the disease. Development of reliable neuropsychological and imaging markers that improve diagnostic accuracy will become increasingly important as disease modifying therapies become available.

title: Differentiating between XXXX -free @entity4 with @entity8 on the basis of neuropsychology and perfusion single-photon emission computed tomography.

answer: @entity9


abstract: OBJECTIVE: To examine @entity1 ( @entity1 ) prevalence, rate of immunomodulatory treatment and frequency of @entity2 ( @entity2 ) antibodies in Vest-Agder, Norway. MATERIALS AND METHODS: @entity0 in the period 1996-2006 who met the Poser criteria for definitive or probable @entity1 were included. Clinical and demographical data, and presence of @entity2 antibodies were registered. RESULTS: A total of 295 @entity0 were identified. The crude prevalence was 180 per 100,000 population (95% CI=160.9-218.0), age-adjusted prevalence was 186 per 100,000 population (95% CI=166.3-225.3). The age-adjusted incidence rates were 7.5 and 8.0 for 1996-2000 and 2001-2006, respectively. Thirty-eight per cent were treated with immunomodulatory agents when compared to 28% in the rest of the country. @entity2 serum antibodies were detected in 7% of @entity0 with @entity1 . CONCLUSIONS: Vest-Agder county has the highest prevalence of @entity1 reported in Norway, and a high treatment rate. @entity2 antibodies were not more prevalent than in healthy individuals.

title: XXXX in Vest-Agder County, Norway.

answer: @entity1


abstract: BACKGROUND: Renal transplant recipients are predisposed to superficial @entity2 caused by graft-preserving immunosuppressive therapy. Reports have documented a wide range of prevalence rates for superficial @entity2 in this @entity0 group. OBJECTIVE: The aim of this study was to determine the prevalence and clinical and mycological features of superficial @entity2 in renal transplant recipients at our center. METHODS: One hundred two consecutively registered renal transplant recipients (34 @entity0 , 68 @entity0 ) and 88 healthy age- and sex-matched @entity0 acting as controls (30 @entity0 , 58 @entity0 ) underwent screening for the presence of superficial @entity2 . Skin scrapings and swabs were obtained from the dorsum of the tongue, upper part of the back, toe webs, and any suspicious lesions. Nail clippings were also collected. All samples were examined by direct microscopy and were stained with calcofluor white. The samples were cultured in Sabouraud dextrose agar, mycobiotic agar, and dermatophyte test medium. Candida species were identified on the basis of germ-tube production, spore formation in cornmeal agar, and results of biochemical testing. Dermatophytes were identified on the basis of colonial and microscopic morphologic features in conjunction with results of physiologic evaluation (in vitro hair perforation test, urease activity, temperature tolerance test, and nutritional test). RESULTS: Sixty-five (63.7%) of the 102 renal transplant recipients had @entity7 , @entity5 , or @entity9 versicolor, whereas only 27 (30.7%) of controls had @entity2 . Pityriasis versicolor was the most common @entity2 in the @entity0 group (36.3%), followed by @entity7 (25.5%), @entity8 (12.7%), and @entity2 (11.8%). Pityriasis versicolor and @entity7 were significantly more common among the renal transplant recipients, whereas the frequency of @entity5 in @entity0 and controls was similar. @entity6 was the main agent responsible for @entity7 , and @entity10 was the most common dermatophyte isolated. Analysis showed that age, sex, and duration of immunosuppression did not significantly affect the prevalence of superficial @entity2 . @entity1 treatment and @entity3 therapy were identified as independent risk factors for superficial @entity2 . CONCLUSIONS: The prevalence of @entity4 with Pityrosporum ovale and @entity6 is increased among renal transplant recipients, probably owing to the immunosuppressed state of this @entity0 population. However, renal transplant recipients are not at increased risk of @entity5 .

title: Superficial XXXX in 102 renal transplant recipients: a case-control study.

answer: @entity2


abstract: Enteric @entity6 is relatively rare, and the preoperative diagnosis is difficult. We report 3 cases of enteric @entity6 : 1 was confirmed by operation, and the other 2 cases were suspected by the @entity0 history. The 1st @entity0 was a 48-year-old female presenting with @entity1 . An abdominal computed tomography scan showed a dilated small intestine and accumulation of @entity2 . We performed partial resection of the small intestine, and an Anisakis @entity5 was found on the wall of the resected bowel. After surgery, the detailed history revealed that the @entity0 consumed a raw @entity7 with vinegar and miso, fermented @entity4 paste. Three days after her operation, 2 @entity0 presenting with @entity1 visited the hospital, and computed tomography scans of the @entity0 showed dilated small intestines and accumulation of @entity2 . By taking @entity0 histories, we found that both of them consumed @entity7 with vinegar and miso, and both were given conservative treatment with fasting and transfusion. By the experience of the 1st case, we could diagnose the following 2 cases as having enteric @entity6 . In conclusion, the possibility of @entity6 should be considered in @entity0 with @entity1 after ingesting raw fish, especially when @entity3 is suspected.

title: Three successive cases of enteric XXXX .

answer: @entity6


abstract: BACKGROUND: The Rumack-Matthew nomogram predicts the risk of hepatotoxicity following acute @entity5 @entity6 based on a serum concentration obtained   >= 4-hour post-ingestion. Some @entity0 with low-risk concentrations at 4 hours may have subsequent values indicating increased risk (above the nomogram treatment line), especially if coingestants that @entity3 are involved. The treatment line currently used to identify low risk @entity0 in the United States, Canada, and Australia begins at 150   mcg/mL (993    mol/L) and intersects at 18.75   mcg/mL (124.1    mol/L) 16 hours post-ingestion. OBJECTIVE: To determine the incidence of nomogram line crossing after acute @entity6 of @entity5 combination products containing an opioid or @entity8 . METHODS: This was a prospective cohort study of hospitalized @entity0 reported to a @entity7 ( @entity7 ) after acute @entity6 of a combination product containing an opioid or @entity8 . If a 4-hour @entity5 concentration was detectable but below the nomogram treatment line, the @entity7 recommended repeat concentrations. @entity0 were entered into the study if at least one subsequent concentration was available. During follow-up calls hospital providers were queried regarding clinical features, treatment, and indicators of @entity1 . RESULTS: Over a 4-year period 76 @entity0 met entry criteria. 5/76 (6.6%) had measureable @entity5 concentrations below the treatment line at or close to 4-hour post-ingestion followed by values above the line obtained at 6.5-12.5 hours. Four of the five were treated with @entity4 and none developed hepatotoxicity. Four of the five had clinical features reported to the @entity7 suggesting @entity2 from the opioid or @entity8 component. CONCLUSION: After acute @entity6 of @entity5 combination products, @entity0 with detectable but non-toxic 4-hour @entity5 concentrations should have repeat concentrations obtained in a time frame that would allow providers to initiate @entity4 treatment, if needed, without undue delay.

title: Nomogram line crossing after XXXX combination product @entity6 .

answer: @entity5


abstract: OBJECTIVES: In February 1994, an National Institutes of Health (NIH) Consensus Development Conference panel unequivocally recommended antimicrobial therapy to eradicate @entity1 in the treatment of @entity3 . The goal of this study was to determine if these recommendations resulted in a change in physician prescribing among an underserved population. METHODS: Computerized Pennsylvania Medicaid data from January 1993 through February 1996 were used to evaluate prescribing patterns in the year before and 2 years after the NIH conference. An interrupted time series model, based on 12,737 outpatient @entity3 encounters, assessed the impact of the conference in influencing physician prescribing. RESULTS: The prescription of antimicrobial agents for the treatment of @entity3 significantly increased across the study period, from 6.5% in January 1993 to 10.2% in February 1996. Similarly, the prescription rate for the proton pump inhibitor, @entity2 , significantly increased from 9.4% in January 1993 to 25.6% in February 1996. Neither trend, however, could be attributed to the NIH Consensus Development Conference. Stratification by physician specialty, ulcer type, nonsteroidal anti-inflammatory drug use, and @entity0 demographics did not affect these results. The traditional treatment approach, using H2-receptor antagonists, remained the preferred pharmacotherapy (72% of all prescriptions). CONCLUSIONS: Two years after the highly publicized NIH conference on the eradication of @entity1 @entity1 , antimicrobial agents were not widely prescribed among the Pennsylvania Medicaid population. In treating this underserved population, physicians do not appear to be using recommendations developed by an NIH expert panel based on recent scientific advances.

title: Influence of the NIH Consensus Conference on XXXX on physician prescribing among a Medicaid population.

answer: @entity1


abstract: INTRODUCTION: More than half of painless solid swellings of the body of the testis are malignant, with a peak incidence in @entity0 aged 30 to 34 years. Most @entity1 are germ cell @entity1 and half of these are @entity2 , which tend to affect older @entity0 and have a good prognosis. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of treatments following orchidectomy in @entity0 diagnosed with stage 1 germ cell @entity1 (confined to testis)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). RESULTS: At this update, 76 records were screened for inclusion. Appraisal of titles and abstracts led to the exclusion of 47 studies and the further review of 29 full publications. Of the 29 full articles evaluated, two systematic reviews and one RCT, were added at this update. Data from long-term follow-up of an already reported study were also added. We performed a GRADE evaluation for seven PICO combinations. CONCLUSIONS: In this systematic overview, we categorised the efficacy for seven interventions based on information about the effectiveness and safety of adjuvant chemotherapy (including different drugs and the number of cycles), adjuvant radiotherapy (including different regimens), adjuvant surgery, and surveillance/observation.

title: @entity1 : germ cell XXXX .

answer: @entity1


abstract: Forty @entity0 , with mainly poor risk haematological @entity1 , were given the new regimen FLAG, comprising @entity11 , @entity9 and @entity5 . Twenty four @entity0 had @entity10 ( @entity10 ), 8 @entity0 @entity8 ( @entity8 ) and a further 8 @entity0 had a variety of other haematological @entity1 . The response rates for 19 relapsed and 4 refractory @entity10 @entity0 were 68% and 100% respectively and comparable to those attained using other regimens, although the numbers are small. Of 8 @entity0 with @entity8 , 7 showed some response with 4 remaining in an improved disease status 5-12 months after FLAG. Follow-up has been too short thus far to provide any survival data in both @entity0 groups. In general, the other smaller group of 8 @entity0 (3 transformed @entity7 ( @entity7 ), 3 @entity4 ( @entity4 ), 2 @entity12 ( @entity12 ) did poorly with response shown in 1 only. The regimen was well tolerated with 4 procedure-related @entity6 deaths. The @entity6 and @entity3 periods are generally short when compared with those from current protocols. The overall modest @entity2 may encourage combination with other anti-leukaemic agents and be of particular use in the aged or heavily pre-treated @entity0 . Preliminary results may favour the setting up of controlled trials to properly evaluate the benefit of FLAG.

title: FLAG is a useful regimen for poor prognosis adult myeloid leukaemias and XXXX .

answer: @entity8


abstract: INTRODUCTION: @entity4 ( @entity4 ) is uncommon but not rare. This paper aims to review the recent evidence for the management of perforated @entity4 of the intestine, consider when chemotherapy should be commenced and examine the likely outcomes and prognosis for @entity0 presenting as @entity1 with this condition. METHODS: MEDLINE and Cochrane databases were searched using @entity2 , clinical presentation, perforation, management and prognosis. The full text of relevant articles was retrieved and reference lists checked for additional articles. FINDINGS: Emergency surgery was required at disease presentation for between 11 and 64% of intestinal @entity4 cases. Perforation occurs in 1-25% of cases, and also occurs whilst on chemotherapy for @entity4 . Intestinal bleeding occurs in 2-22% of cases. Obstruction occurs more commonly in small bowel (5-39%) than large bowel @entity4 and intussusceptions occur in up to 46%. Prognosis is generally poor, especially for @entity3 . CONCLUSIONS: There is a lack of quality evidence for the elective and emergency treatment of @entity4 involving the small and large intestine. There is a lack of information regarding the impact an emergency presentation has on the timing of postoperative chemotherapy and overall prognosis. It is proposed that in order to develop evidence-based treatment protocols, there should be an intestinal @entity4 registry.

title: XXXX --a review of the management of emergency presentations to the general surgeon.

answer: @entity2


abstract: PURPOSE: To determine the spectrum, clinical profile and risk factors for poor visual outcome in @entity0 of post @entity2 surgery @entity5 . METHODS: Data from 124 eyes were analysed. Various clinical and microbiological parameters were evaluated and risk factors for unfavourable outcome identified. RESULTS: The mean age of the @entity0 was 59.50 +/- 13.75 years; 60.5% were males. The median surgery-symptom interval was 7 days (mean 15.81 +/- 24.01) and the medium symptom-presentation interval 7.5 days (mean 14.19 +/- 19.13). @entity4 were seen in 29%, hypopyon in 62 (50%). Smear positivity was 52.5% and culture positivity 38%. Equivocal microbiological positivity was seen in 22 (18%), bacterial 12 (10%), fungal 27 (21.5%), polymicrobial 8 (6.5%) and negative 55 (44%). 20% eyes had @entity3 at last follow-up. Poor visual acuity at presentation, presence of intraocular lens, shorter surgery-symptom interval, corneal and surgical wound infiltrates, loss of red reflex, microbiological positivity of the vitreous tap and systemic @entity1 were significant risk factors for unfavourable outcome. CONCLUSION: Our data highlights a low culture positivity and a predominance of fungal pathogens as a cause of post @entity2 surgery @entity5 . The visual outcome in these @entity0 is still dismal and better treatment strategies should be evolved keeping in mind the microbiological spectrum. The risk factors identified may be helpful in prognosticating the outcome in such @entity0 .

title: Spectrum and clinical profile of post @entity2 surgery XXXX in north India.

answer: @entity5


abstract: Increased ECM in @entity1 PVs. INTRODUCTION: Cell uncoupling due to @entity0 or increased extracellular collagen matrix (ECM) affects the formation of ectopic focal activity. Whether or not the increase of ECM also exists in the pulmonary veins (PVs) with rapid atrial pacing is unknown. We sought to test the hypothesis that in chronic atrial pacing @entity1 with sustained @entity2 ( @entity2 ), the amount of ECM was increased in both atria and the PVs. METHODS AND RESULTS: We induced sustained @entity2 in @entity1 by rapid atrial pacing. Computerized mapping techniques were used to map both atria and the PVs. We also used histological assessment to quantify the amount of ECM. After 118+/-24 days of rapid atrial pacing, sustained @entity2 was induced in 7 @entity1 . Repetitive rapid activities (RRAs) either continuously or intermittently arose from the PVs during sustained @entity2 . Histological study shows that there was no @entity0 in both atrial free walls and the PVs. However, the amount of ECM was increased in these regions. The mean ECM surface area fraction at each region in the @entity1 with sustained @entity2 was all significantly higher compared to the corresponding region in normal @entity1 . Similarly, the heterogeneity of the ECM surface area fraction at each region in the @entity1 with sustained @entity2 was also all significantly higher compared to normal @entity1 . CONCLUSIONS: In chronic atrial pacing-induced sustained @entity2 , structural remodeling (i.e., inhomogeneous increase of ECM) also involves the PVs. Reduced coupling of the myocytes in the PV due to histological changes may provide an additional mechanism facilitating RRAs.

title: Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained XXXX .

answer: @entity2


abstract: OBJECTIVES: We sought to compare the maternal and fetal outcomes of @entity0 with severe @entity5 submitted to percutaneous @entity1 versus open mitral valve commissurotomy (MVC) during pregnancy. BACKGROUND: @entity3 in @entity0 with @entity5 complicating pregnancy is a common problem in developing countries. Since 1984, percutaneous dilation of the mitral valve using a balloon catheter has become a therapeutic alternative to open heart surgery. Although the efficacy of percutaneous mitral @entity1 is well established, its results have never before been compared with the results of commissurotomy during pregnancy. METHODS: We compared the clinical and obstetric complications in 45 @entity0 who were treated with percutaneous mitral @entity1 (group I, n = 21; from 1990 to 1995) or open MVC (group II, n = 24; from 1985 to 1990) for severe @entity3 due to @entity5 during pregnancy. RESULTS: In our study, percutaneous @entity1 of the mitral valve had a success rate of 95% (Gorlin formula) and 90.5% (echocardiographic "pressure half-time" method), as demonstrated by the final mitral valve area achieved. This improvement was followed by a marked decrease in the mitral valve gradient, left atrial pressure and mean pulmonary artery pressure. @entity0 in both groups had similar improvements in symptoms. @entity0 who underwent percutaneous @entity1 had significantly fewer @entity4 , with a reduction in fetal and neonatal mortality (1 death in group I vs. 8 in group II, p = 0.025). CONCLUSIONS: @entity2 is safe and effective and appears to be preferable for the fetus, compared with open MVC during pregnancy.

title: @entity2 in comparison with open mitral valve commissurotomy for XXXX during pregnancy.

answer: @entity5


abstract: The present studies were conducted in conscious, instrumented @entity0 to evaluate measurements of aortic peak flow velocity ( @entity3 ) as an index of myocardial contractility. Because our previous studies had characterized/verified procedures to determine pressure-derived indices of contractile function in the anesthetized, ventilated, open-chest @entity0 , we first correlated @entity3 with (a) maximum rate of left ventricular pressure development (max +dP/dt) and (b) a contractility index derived by dividing max +dP/dt by left ventricular pressure at max +dP/dt [(dP/dt)/P] in anesthetized @entity0 (n = 5). The positive inotropic agent, @entity2 , given by bolus intravenous injection (0.2 microgram), significantly and concurrently increased dP/dt, (dP/dt)/P, and @entity3 . The negative inotropic agent, @entity1 , given by bolus intravenous injection (2 mg/kg), significantly and concurrently attenuated all of the above measurements. When control, @entity2 , and @entity1 responses were used to calculate multivariate correlation coefficients among dP/dt, (dP/dt)/P, and @entity3 , r values ranged from 0.74 ( @entity3 vs. dP/dt) to 0.84 (dP/dt vs. (dP/dt)/P) to 0.91 ( @entity3 vs. (dP/dt)/P). A separate group of @entity0 (n = 4) was surgically implanted with ascending aortic blood flow sensors, carotid artery and jugular vein catheters. Intravenous @entity2 (0.2 microgram, bolus) elicited increased cardiac (heart rate and cardiac output) and decreased peripheral vascular resistance (mean arterial blood pressure) beta-adrenergic receptor agonist effects. @entity1 (2 mg/kg, i.v. bolus) produced hemodynamic effects consistent with cardiovascular beta-adrenergic receptor blockade. @entity2 and @entity1 had directionally appropriate, and significant effects on @entity3 in the conscious @entity0 . When compared with @entity3 values under control conditions in the anesthetized @entity0 , conscious @entity0 values are approximately double those observed under anesthesia; however, the relative @entity3 responses to @entity2 and @entity1 were not affected. Therefore, the present studies provide evidence that aortic @entity3 can be utilized as an estimate of heart contractile performance, i.e., myocardial contractility, in the conscious, instrumented @entity0 .

title: Aortic peak flow velocity as an index of myocardial contractility in the conscious XXXX .

answer: @entity0


abstract: Insulin-like growth factors (IGFs) play an important role in regulating vascular smooth muscle cell (VSMC) proliferation and directed migration. IGFs exert these biological actions through the activation of the @entity4 and its downstream signaling network. While the involvement of the IRS-PI3 kinase- @entity1 pathway in mediating the chemotactic and mitogenic actions of IGFs is clear, the role of the mitogen-activated protein kinase (MAPK) signaling pathway is still under debate. In this study, the role of @entity2 in mediating the chemotactic and mitogenic actions of @entity0 in cultured porcine VSMCs was investigated. @entity0 treatment caused a significant increase in the phosphorylation state, as well as the kinase activity, of @entity2 . Compared to the strong and sustained MAPK activation induced by platelet-derived growth factor-BB, the @entity0 -induced MAPK activation was weaker and more transient. Specific inhibition of the MAPK activation by @entity5 or @entity6 , two selective MEK inhibitors, significantly inhibited @entity0 -stimulated cell proliferation, and reduced the number of cells that migrated towards @entity0 . The p38 MAPK inhibitor @entity3 had no such effect. Likewise, depletion of @entity2 using antisense oligonucleotides abolished the @entity0 -induced VSMC migration and proliferation. These results suggest that the chemotactic and mitogenic responses of VSMCs to @entity0 require the activation of @entity2 .

title: The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of XXXX .

answer: @entity2


abstract: UNASSIGNED: Isolated @entity1 ( @entity1 ) may be associated with stable or unstable coronary events despite the absence of @entity3 . Impaired coronary flow dynamics and myocardial perfusion have been demonstrated in stable @entity0 with ectatic coronary arteries. We aimed to assess whether epicardial flow and tissue-level perfusion would be improved by @entity4 in myocardial regions subtended by the ectatic coronary arteries in @entity0 with @entity1 . A total of 60 @entity0 with @entity1 were identified of 9,780 @entity0 who underwent elective coronary angiography. @entity0 were randomized to 5  mg of intracoronary @entity4 or saline. Coronary blood flow of the microvascular network was assessed using myocardial blush grade ( @entity5 ) technique. The thrombolysis in @entity2 (TIMI) flow grade and TIMI frame count (TFC) were used to assess epicardial coronary flow. @entity5 (from 2.4 to 2.6, p  = 0.02), TIMI flow grades (from 2.4 to 2.8, p <0.001), and TFC (from 35 to 26, p <0.001) were significantly improved after @entity4 , whereas no significant change was noticed after saline (from 2.4 to 2.4, p  = 0.86 for @entity5 ; from 2.3 to 2.3, p  = 0.71 for TIMI flow grade; and from 35 to 33, p  = 0.43 for TFC). @entity4 provided amelioration of the altered coronary flow dynamics, which was suggested as the pathophysiological influence of @entity1 . In conclusion, the favorable effects of the @entity4 on myocardial perfusion were observed at both epicardial and tissue levels.

title: Effect of XXXX on Coronary Artery Flow and Myocardial Perfusion in @entity0 With Isolated Coronary Artery Ectasia and Either Stable Angina Pectoris or Positive Myocardial Ischemic Stress Test.

answer: @entity4


abstract: A signaling cascade that includes @entity2 ( @entity2 ), Ras, and @entity7 regulates @entity5 ( @entity6 ) gene expression in epidermal keratinocytes (Efimova, T., LaCelle, P., Welter, J. F., and Eckert, R. L. (1998) J. Biol. Chem. 273, 24387-24395 and Efimova, T., and Eckert, R. L. (2000) J. Biol. Chem. 275, 1601-1607). Because signal transfer downstream of @entity7 may involve several MAPK kinases (MEKs), it is important to evaluate the regulatory role of each MEK isoform. In the present study we evaluate the role of @entity4 in transmitting this signal. Constitutively active @entity4 (caMEK6) increases @entity6 promoter activity and increases endogenous @entity6 levels. The caMEK6-dependent increase in gene expression is inhibited by the p38 MAPK inhibitor, @entity1 , and is associated with a marked increase in @entity0 MAPK activity; JNK and ERK kinases are not activated. In addition, @entity6 gene expression is inhibited by dominant-negative @entity0 and increased when caMEK6 and @entity0 are co-expressed. caMEK6 also activates @entity3 , but @entity3 inhibits the caMEK6-dependent activation. These results suggest that @entity4 increases @entity6 gene expression by regulating the balance between activation of @entity0 , which increases gene expression, and @entity3 , which decreases gene expression.

title: @entity4 regulates human @entity5 gene expression via a @entity0 - and XXXX -dependent mechanism.

answer: @entity3


abstract: BACKGROUND AIMS: Bone marrow (BM) transplantations are an accepted therapeutic strategy for hematologic conditions. In the past decades, interest for BM-derived cell therapy has extended toward the field of regenerative medicine. Irrespective of the treatment strategy, its success depends on the amount of cells available for transplantation. Both @entity0 and procedural factors have been shown to influence the cell density of the BM aspirate. In the present study, the influence of core diameter of the BM aspiration device on cell density of the BM aspirate is studied. METHODS: BM harvesting procedures performed in a clinical trial investigating the effect of BM cell therapy in @entity0 with severe @entity3 were retrospectively studied (clinicaltrials.govNCT00371371). @entity0 underwent BM harvesting through the use of either a 15-gauge (n  = 85) or an 8-gauge (n  = 75) needle. The numbers of harvested white blood cells (WBC) and @entity2 (+) @entity1 ( @entity1 ) were quantified. RESULTS: The amount of WBC per milliliter of BM aspirate was significantly higher when the 8-gauge needle (27.8  * 10(6) WBC/mL [95%CI 25.4-30.5  * 10(6)]) was used compared with the smaller 15-gauge core needle (20.1  * 10(6) WBC/mL [95% confidence interval (CI), 18.7-21.7  * 10(6)], P  < 0.001). For the amount of @entity2 (+) @entity1 , a similar pattern was observed (185  * 10(3) @entity1 /mL [95% CI, 161-213  * 10(3)]; 114  * 10(3) @entity1 /mL [95% CI, 96-134  * 10(3)]; P  < 0.001). CONCLUSIONS: The application of a BM aspiration device with a larger core diameter is associated with an increased cell density of the BM aspiration product in @entity0 with severe @entity3 .

title: Core diameter of bone marrow aspiration devices influences cell density of bone marrow aspirate in XXXX with severe @entity3 .

answer: @entity0


abstract: BACKGROUND: Cymbopogon citratus (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C. citratus aqueous extract against @entity1 induced by @entity2 ( @entity3 ), in male @entity0 . MATERIALS AND METHODS: Twenty-five @entity0 were randomly divided into five different groups of five animals in each group; (1) Control. (2) Received @entity3 (0.5%) with drinking water. (3), and (4) received @entity3 and C. citratus (100 mg  kg(-1) b wt), @entity5 (250 mg  kg(-1) b wt) respectively. (5), was given C. citratus alone. The treatments were administered for 30 days. Blood samples were collected and serum was used for biochemical assay including liver enzymes activities, total protein, total @entity6 and @entity7 , @entity10 in serum and liver homogenates. Liver was excised and routinely processed for histological examinations. RESULTS: C. citratus attenuated @entity4 due to @entity3 administration as indicated by the significant reduction (p<0.05), in the elevated levels of ALT, AST, @entity12 , LDH, @entity9 , and @entity8 in serum and liver homogenates; increase in TP and @entity11 levels in serum and liver homogenates; and improvement of liver histo-pathological changes. These effects of the extract were similar to that of @entity5 which used as antioxidant reference. CONCLUSION: C. citratus could effectively ameliorate @entity3 -induced oxidative stress and prevent @entity1 in male @entity0 .

title: Hepatoprotective effect of cymbopogon citratus aqueous extract against @entity2 -induced @entity1 in male XXXX .

answer: @entity0


abstract: OBJECTIVE: To compare the effects of @entity6 and micronized @entity4 on the lipid profile of postmenopausal @entity0 receiving conjugated @entity5 @entity2 . STUDY DESIGN: A prospective, clinical study of the changes in lipoprotein profile evaluated in 123 postmenopausal @entity0 receiving conjugated @entity2 alone (group I), conjugated @entity2 combined with @entity6 (group II) or micronized @entity4 (group III) before treatment and six months after. RESULTS: Group I had significantly increased high-density lipoprotein @entity1 (HDL-C) levels (14.4%) after six months as well as decreased low-density lipoprotein @entity1 (LDL-C) concentrations (-6.61%), LDL/HDL and total @entity1 /HDL-C ratios (P < .05). In groups II and III, HDL-C concentrations increased 4.58% and 5.44%, respectively, after six months. LDL-C levels were markedly decreased in group II (8.98%). There was no significant reduction in LDL-C levels in group III. Total @entity1 levels were significantly decreased only in group II (-4.93%). @entity3 levels were increased with statistical significance only in group III (21.2%, P < .05). LDL/HDL and total @entity1 / HDL-C ratios were significantly decreased in group II, and this effect was more pronounced in group I. There was no change in the ratios in group III. CONCLUSION: Conjugated @entity2 replacement therapy had a persistent cardioprotective effect in postmenopausal @entity0 , based on the positive effect on lipoprotein metabolism. Both natural and synthetic progesterones blunt the beneficial effects of @entity2 on the lipoprotein profile, and micronized @entity4 is not superior to @entity6 .

title: Changes in the lipoprotein profile in postmenopausal XXXX receiving hormone replacement therapy. Effects of natural and synthetic @entity4 .

answer: @entity0


abstract: Clinical characteristics of 97 @entity0 with @entity2 associated with a small single cerebral @entity4 (SSCCCTL), measuring 20 mm or less were analysed. The mean age was 20 years and 60% were in the first and second decades. Eighteen (18.5%) @entity0 had a previous history of unprovoked @entity3 , with complex partial @entity3 (61%) being the most common type. @entity3 could be localized to a single ILAE site in 73% of @entity0 . None had @entity1 and electroencephalograph abnormalities were noted in 29% of @entity0 . Fifty-one (53%) @entity0 had @entity3 and were more common with frontal location. By 7 years 71.5% (95% confidence intervals (CI) 53.7-85.4) of @entity0 achieved 3-year remission and 66% (CI 32.4-88.2) had achieved 5-year remission. The clinical pattern of the @entity3 was clearly distinctive to allow it to be localized to the location of the lesion on computerized tomography (CT) scan in 25 (26%) @entity0 and in another 31 (31%) @entity0 nearer to the anatomical site of the lesion on the CT scan. There was discordance between clinical localization and CT location of the lesion in 15 @entity0 . Nine of the 10 @entity0 with occipital or parieto-occipital location had focal @entity3 with secondary generalization. Both @entity0 with temporal location had motor @entity3 . The relevance of these findings to the @entity3 propagation was discussed.

title: Clinical characteristics, @entity3 spread patterns and prognosis of XXXX associated with a single small cerebral @entity4 .

answer: @entity3


abstract: BACKGROUND/PURPOSE: Unfavorable histology (UH) in @entity7 has been linked to malfunction of the @entity4 @entity1 suppressor gene, which regulates (1) the endogenous angiogenesis suppressor @entity8 ( @entity8 ) and (2) @entity5 ( @entity5 ). The authors hypothesized that clinically aggressive favorable histology @entity7 ( @entity3 ), like UH, but distinct from standard-risk @entity3 disease, would display altered @entity4 / @entity8 function and upregulated angiogenesis. METHODS: Three @entity7 specimens manifesting different histology and clinical behavior were obtained: clinically aggressive UH, clinically aggressive @entity3 , and standard-risk @entity3 disease. Xenografts were induced intrarenally in athymic @entity2 . @entity4 , @entity8 , and @entity5 status and @entity6 were assessed in @entity1 tissues. Lungs were evaluated for @entity0 . RESULTS: Clinically aggressive @entity3 @entity7 displayed progressive alteration in @entity4 / @entity8 status and upregulation of @entity5 . Such alteration was observed in the UH @entity1 , but was absent from the standard-risk @entity1 . Xenografts from clinically aggressive @entity1 displayed brisk neoangiogenesis and yielded lung metastases. CONCLUSIONS: This is the first report of altered @entity4 / @entity8 function in association with clinically aggressive behavior in @entity3 @entity7 . These characteristics were not observed in parallel studies of a nonaggressive @entity1 . Loss of wild-type @entity4 function may contribute to disease progression in @entity3 @entity7 , in part by upregulation of @entity5 .

title: XXXX accumulation in favorable-histology @entity7 is associated with angiogenesis and clinically aggressive disease.

answer: @entity4


abstract: OBJECTIVE: To describe attitudes toward the @entity1 ( @entity1 ) among Department of Veterans Affairs (VA) nursing home care unit (NHCU) clinical leadership. DESIGN: Cross-sectional online survey using structured (quantitative) and open-ended (qualitative) items. SETTING: Approximately 97 VA Medical Center NCHUs nationwide. @entity0 : A total of 289 directors of nursing, medical directors, @entity1 coordinators, nurse managers and other clinical management staff. MEASUREMENTS: Quantitative ratings of the @entity1 's accuracy, usefulness for initial and ongoing care planning, and utility for quality improvement; content analysis of open-ended items describing perceived causes of inaccuracy and reasons for use/nonuse in care planning and quality improvement. RESULTS: Although quantitative ratings were generally positive, qualitative analysis yielded a number of emergent themes regarding data accuracy, team functioning, timeliness of assessments, and validity of the @entity1 tool itself. Medical directors were somewhat less positive about the @entity1 than were other NHCU leadership. Very large and very small facilities were less likely to view the tool as useful and to use it for care planning and quality improvement. CONCLUSIONS: NHCU clinical leadership clearly has a "love-hate" relationship with the @entity1 . They value information it provides, but identify a number of weaknesses that limit its utility for clinical use.

title: "Sometimes XXXX don't fit in boxes": attitudes toward the minimum data set among clinical leadership in VA nursing homes.

answer: @entity0


abstract: The present study compares the effects of @entity10 , a novel @entity7 channel opener, with those of @entity9 and @entity8 on blood pressure and other haemodynamic parameters. In conscious, spontaneously @entity2 @entity0 (SHR) the oral dose of @entity10 for lowering blood pressure was 10 times lower than that of @entity9 and some 100 times lower than that of @entity8 . In addition, the duration of antihypertensive activity of @entity10 was longer than that of @entity9 or @entity8 . The @entity6 evoked by @entity10 and @entity9 was of shorter duration than the antihypertensive effect of either agent. In a repeat, once daily dosing experiment no tolerance was observed to the antihypertensive effect of @entity10 over a 22-day period. In conscious normotensive @entity4 @entity10 was 10 times more potent than @entity9 and 1,000 times more potent than @entity8 in reducing blood pressure. The duration of @entity5 activity was in excess of 5 h for each agent. In anaesthetised @entity3 all three agents reduced mean arterial pressure (MAP) and total peripheral resistance (TPR), while increasing cardiac output (CO) via a rise in @entity1 volume (SV). Both @entity10 and @entity9 significantly reduced femoral (FVR) and mesenteric vascular resistances (MVR), while only @entity9 reduced renal vascular resistance (RVR). @entity10 is a potent new antihypertensive agent that compares favourably with @entity9 and @entity8 .

title: Preclinical pharmacology of @entity10 , a new XXXX channel opener.

answer: @entity7


abstract: UNASSIGNED: Inherited mild @entity11 belongs to one of the most underdiagnosed @entity5 disorders so far. This is, because most @entity0 do not develop @entity5 complications in daily life. @entity0 , methods: A @entity0 (age: 64 years) without a history of @entity5 presented with @entity9 , @entity3 , @entity4 and @entity5 from the right tonsil necessitating tonsillectomy. Histologic and immunohistochemical evaluation revealed @entity10 . @entity7 status showed significantly elevated D-dimer and decreased FXIII levels (FXIII-activity 35%, FXIIIA-Ag 16-26%). Plasma mixing studies excluded neutralizing antibodies against FXIII. RESULTS: A novel heterozygous @entity12 gene nonsense mutation ( @entity13 , @entity14 ) was found confirming heterozygous FXIII-A deficiency. The same mutation was detected in two further asymptomatic relatives. For further clinical management the @entity0 was transfused with FXIII-concentrate and showed an adequate increase of FXIII ruling out @entity6 to be induced by increased turnover. Despite this haemostatic management and antifibrinolytic treatment the @entity0 had to undergo several revisions due to delayed, Hb relevant @entity5 after cervical lymph nodes extirpation and resection of tonsil. Two chemotherapy cycles with @entity8 and palliative radiotherapy of the neck area were performed, but the @entity0 died unfortunately two months after diagnosis. CONCLUSIONS: It is a unique case showing the combination of a highly aggressive @entity10 and presence of @entity2 . It is also a rare example demonstrating the benefit of FXIII genotyping besides the expected acquired @entity6 possibly due to @entity1 induced increased consumption by elevated crosslinking of fibrin fibers.

title: XXXX -induced @entity5 in inherited, heterozygous FXIII-A  deficiency.

answer: @entity1


abstract: The objective was to study the effects of @entity0 -specific vaccine immunotherapy administered with either @entity6 ( @entity6 ) or @entity8 ( @entity8 ) in @entity0 with @entity1 . Short-term cell lines were established from @entity1 tissue resected from @entity0 with @entity1 for use as @entity1 cell vaccines. Successful cultures were expanded to 1 to 2 x 108 cells, irradiated, and cryopreserved in aliquots of 106 cells for intradermal testing of delayed @entity1 hypersensitivity and 107 cells for subcutaneous vaccinations. The study design was that of a randomized phase 2 trial. @entity0 were stratified by @entity1 type and by whether they had measurable disease at the time vaccination was to commence, and then randomized to receive either 100 MIU @entity6 subcutaneously or 500 microg @entity8 subcutaneously at the time of each @entity1 cell vaccination. Following a baseline test of @entity2 ( @entity2 ) to an intradermal injection of 106 irradiated @entity1 cells, @entity0 received 3 weekly subcutaneous injections of 107 cells, had a repeat @entity2 test at week 4, then received monthly vaccinations for 5 months. A positive @entity2 test was defined as at least 10 mm of induration; survival was determined from the first @entity2 test. There were 98 @entity0 enrolled with a median follow-up of over 4 years. The most prevalent diagnoses were @entity5 (51), @entity7 (18), and soft-tissue @entity4 (14). There were 49 @entity0 (26 @entity0 , 23 @entity0 , average age 50.4 years) randomized to @entity6 and 49 (28 @entity0 , 21 @entity0 , average age 54.1 years) to @entity8 . The average numbers of vaccine and adjuvant injections were 6.3 and 5.9, respectively. For the @entity0 who received @entity6 , the objective response rate was 0 of 21; for @entity0 who received @entity8 the response rate was 1 of 26. Only eight @entity0 (four from each arm) had a positive baseline @entity2 reaction to @entity1 . The @entity1 @entity2 test converted from negative to positive in 13 of 45 of the @entity6 group and 11 of 43 of the @entity8 group. With 29 @entity0 deceased in the @entity6 arm and 31 in the @entity8 arm, the 2-year and 5-year survival rates were 45% and 29% for the @entity6 arm and 41% and 23% for the @entity8 arm ( @entity3 ). Both adjuvants were well tolerated and results were similar in both arms of the study. Both adjuvants were associated with a 25% to 30% rate of @entity2 conversion and a 25% 5-year survival rate. Immune recognition of @entity1 can be induced with this approach.

title: @entity6 or granulocyte-macrophage colony-stimulating factor administered as adjuvants with a vaccine of irradiated @entity1 cells from short-term cell line cultures: a randomized phase 2 trial of the XXXX biotherapy research group.

answer: @entity1


abstract: UNASSIGNED: Genetic background plays an important role in the development of @entity3 . A genome-wide association study (GWAS) showed that nine loci are associated with the disease, six of which contain genes that are involved in Wnt signaling ( @entity7 , @entity9 , @entity5 , @entity11 , @entity8 , @entity10 ). To obtain insight in the role of these genes, we performed expression studies on affected and unaffected @entity0 's tissues. Surgically obtained nodules and cords from eight Dupuytren's @entity0 were compared to @entity0 -matched control tissue (unaffected transverse palmar fascia). The Wnt-related genes found in the GWAS, the classical Wnt-downstream protein @entity4 , as well as (myo)fibroblast markers were analyzed using real-time qPCR and immunohistochemical stainings for mRNA levels and protein levels, respectively. The collagen-coding genes @entity6 and @entity1 were highly upregulated on mRNA level, both in cords and nodules. Three Wnt-related genes were found to be differently regulated compared to control tissue: @entity7 was downregulated in nodules, @entity5 was upregulated in nodules, and @entity8 was upregulated in nodules and cords. Immunohistochemistry revealed significantly less staining of @entity7 in cords, but significantly more staining for @entity5 in nodules. There was significantly more staining of @entity2 in nodules and cord and @entity4 in nodules than in control tissue. We found differences in expression, both at mRNA and protein level, in several Wnt-related genes found earlier to be associated with @entity3 . Of these, @entity5 was upregulated and found in close association with both @entity2 and @entity4 expressing cells, making it a candidate pro-fibrotic mediator in @entity3 .

title: Further evidence of the involvement of the Wnt signaling pathway in XXXX .

answer: @entity3


abstract: BACKGROUND: Anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty have been widely used to treat @entity0 with cervical spondylotic @entity3 and/or @entity4 . In our clinical practice, many @entity0 with @entity5 also complain of @entity1 , and wish to know if the surgical treatment for @entity5 can also alleviate this symptom. Considering that there is no literature concerning this extra benefit of surgical manipulation on @entity5 , we have carried out this retrospective study. METHODS: Among the @entity0 treated with anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty in our institute for cervical spondylotic @entity3 and/or @entity4 between February 2002 to March 2011, 108 of whom that have complained about @entity1 at the same time were included in this study. Those @entity0 were followed by 25 to 145  months. Severity of @entity1 before the surgery and at the last follow up was recorded by VAS @entity2 scores and compared among the @entity0 with different surgical methods using SPSS17.0 software. One way ANOVA was used to compare VAS scores between the groups, paired sample t-tests were used to compare the differences in a group at different time points. RESULTS: @entity1 was significantly alleviated in all groups (P   <   0.01). Respectively, 75.0  % of the @entity0 in the ACDF group, 84.6  % of the @entity0 in the TDR group and 82.2  % of the @entity0 in the laminoplasty group were significantly relieved of the @entity1 after the surgery. No significant differences were found with the VAS score at the last follow up among the groups (P   >   0.05). No significant differences were found among the groups comparing the degree of alleviation of VAS scores before and after the surgery (P   >   0.05). DISCUSSION: Considering that all the three procedures in the current study have achieved similar effect on alliviating @entity1 in @entity0 with cevical @entity3 , and that what they have in common was that was the decompression of spinal cord, it can be assumed that the @entity1 associated with @entity5 may be the result of compression on the spinal cord. CONCLUSIONS: Anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty can all significantly alleviate @entity1 in @entity0 with cervical spondylotic @entity3 and/or @entity4 . No surgical technique is better than any other technique on alleviating cervical @entity1 associated with cervical spondylotic @entity3 and/or @entity4 .

title: Effect of different surgical methods on XXXX associated with cervical spondylotic @entity3 and/or @entity4 .

answer: @entity1


abstract: BACKGROUND: Studies on the relationship between @entity3 concentrations and blood pressure have yielded inconsistent results. Therefore, this study investigated the prospective association of total @entity3 (TT) concentrations with risk of incident @entity1 and blood pressure change in 1,484 @entity0 aged 20-79 years. METHODS: Data from the population-based Study of Health in Pomerania, Germany, were used. Serum TT concentrations, measured by chemiluminescent enzyme immunoassays, were categorised into age-specific quartiles. Generalised Estimating Equation (GEE) models, adjusted for age, waist circumference, physical activity, smoking and @entity2 consumption were specified. RESULTS: During a median follow-up time of 5.0 years, the prevalence of @entity1 increased from 50.6% to 57.1%. TT concentrations were significantly lower in @entity0 with baseline and incident @entity1 . Analyses revealed that @entity0 with baseline TT concentrations in the lowest quartile had an increased risk of incident @entity1 (odds ratio (OR), 1.19 (95% CI, 1.10-1.28)) compared to @entity0 with higher TT concentrations. Furthermore, we found a significant inverse association of TT concentrations and blood pressure, showing that @entity0 with baseline TT concentrations in the lowest quartile showed the slightest change in systolic blood pressure (-6.01 mmHg), diastolic blood pressure (-2.11 mmHg) and pulse pressure (-3.98 mmHg). Sensitivity analyses in a subpopulation of men without antihypertensive medication confirmed these findings. CONCLUSION: These results show that low male TT concentrations are predictive of @entity1 , suggesting TT as a potential biomarker of increased cardiovascular risk.

title: Inverse association between total XXXX concentrations, incident @entity1 and blood pressure.

answer: @entity3


abstract: A retrospective review was conducted of 122 charts of @entity0 with clinically diagnosed @entity1 (CDAD) who had participated in a @entity3 study at the Mayo Clinic from 1965 to 1970. DSM-III-R diagnoses were assigned based on the longitudinal description of symptoms detailed in the Mayo Clinic medical records of the hospitalizations; clinic, home, and nursing home visits; and state hospital admissions. Thirty @entity0 (25%) were found to have a @entity6 episode during their course of CDAD that occurred during inpatient admissions; 50% (15 of 30) of the @entity6 episode occurred in @entity0 ages 80 to 89. Among @entity0 with a @entity6 episode, 50% died within one year of the @entity6 episode and 64% died within two years. Of 13 @entity0 , 10 (77%) had multiple @entity6 episodes within two years. Admitting diagnoses were mainly primary degenerative @entity3 of the @entity1 with @entity6 . Only 3 (10%) demented @entity0 experienced @entity6 episodes during a medical admission. No @entity2 occurred during hospitalization for the years covered by this study. A psychiatric consultation was requested in only 17 (14%) @entity0 ; 88% of these @entity0 received diagnoses involving PDDAT, late onset. An additional diagnosis included @entity4 . Psychopharmacology was the major management strategy (82% of @entity0 with a @entity6 episode received medication) with a resolution of symptoms within 48 hours. At discharge, only 2 (7%) @entity0 failed to clear the increased degree of @entity5 .

title: XXXX episodes during the course of clinically diagnosed @entity1 .

answer: @entity6


abstract: Sixty @entity0 with chronic @entity3 or lumboischialgia with exacerbation for at least 1 month were included in the study. A main group consisted of 40 @entity0 and a control group of 20 @entity0 . All @entity0 took @entity5 in dosage 100 mg per day from the 1st day. Versatis was prescribed to @entity0 of the main group from the 6th day. One-three plates were applied to the most painful spine areas and low extremities for 12 h during 5 days. To assess treatment efficacy, scales for measuring @entity3 , @entity6 , @entity1 (NPS) as well as the Global Impression scale (CGI) and quality of life (EQ-5D) were used. A significant clinical effect was observed in 63% of @entity0 of the main group: the additional reduction of @entity2 by about a quarter, decrease of @entity6 intensity, improvement of functional activity - spinal flexion-extension, ability to standing and quality of life. The NPS revealed that the use of versatis resulted in the significant decrease of "neuropathic" characteristics of @entity2 ; this effect remained after the end of treatment. The anesthetic effect of plates emerged in 1,2+/-1,1h after application, reached the maximum after 3,8+/-2,0 h, and continued during 4,7+/-2,2 h after removing the plates from the skin. The safety of @entity4 -coated plates was observed.

title: [The use of @entity4 -coated plates (versatis) in the treatment of XXXX ].

answer: @entity3


abstract: INTRODUCTION: Resistance to Carbapenems in Klebsiella may be due to @entity2 hydrolysing enzymes. Accurate detection of carbapenemase must be done for @entity0 treatment and epidemiological purposes. AIM: To detect carbapenemase production by performing Modified Hodge Test (MHT), @entity1 ( @entity1 ) for @entity4 ( @entity4 ) and PCR for blaKPC gene, to evaluate the performance of MHT using MacConkey Agar (MCA) and to access the value of MHT for carbapenemase detection. MATERIAL AND METHODS: Using a prospective laboratory study design, 153 Extended Spectrum Beta-Lactamases (ESBL) producing @entity3 from clinical samples of @entity0 admitted in the Kasturba Medical College were collected from January 2014 to December 2015. Isolates resistant to carbapenems by disk diffusion were subjected to MHT on MCA and @entity5 ( @entity5 ). All isolates were tested for ( @entity4 ) production by Imipenem and Imipenem-EDTA @entity1 and subjected to PCR for the presence of blaKPC gene. RESULTS: Out of 153 isolates, 54 were resistant to one of the carbapenems. Among these, 13 were positive for MHT on @entity5 , while 23 were positive by MHT on MCA. Number of @entity4 producers was 23 (42.5%), while blaKPC was detected in 2 out of the 54 isolates. CONCLUSION: Though detection of drug resistance gene remains the method of choice, it can be performed only in centers with adequate resources. Hence, for most laboratories in resource poor countries, the MHT performed on MCA with concomitant @entity1 for @entity4 detection seem to be a better option for detection of @entity2 resistance.

title: Approach to Carbapenemase Detection in XXXX in Routine Diagnostic Laboratories.

answer: @entity3


abstract: PURPOSE OF REVIEW: Management of @entity11 vera and @entity10 requires understanding of the key concepts regarding diagnosis, risk stratification, and management. RECENT FINDINGS: Essential @entity5 and @entity11 vera are among the Philadelphia chromosome negative @entity1 . They are characterized by overproduction of blood cells and their complications include @entity4 , @entity3 , and progression to @entity7 or @entity6 ( @entity6 ). Management of @entity9 requires recognition of the risk factors for @entity4 and @entity3 . Risk stratification allows the clinician to make a treatment plan that may include antiplatelet therapy with @entity2 alone or in combination with therapeutic phlebotomy in the case of @entity11 vera, or cytoreductive therapy for high-risk @entity0 with either @entity10 or @entity11 vera. Hydroxyurea remains first-line therapy for high-risk @entity0 with @entity9 , whereas second-line options include @entity13 , pegylated-IFNa-2a, and the @entity12 inhibitor @entity14 . The current evaluation of pegylated- @entity8 a in global phase II and III studies will provide clarity to the potential long-term benefit and risks associated with this biologic in @entity0 with @entity9 . Novel therapeutics aimed at prevention of disease progression to @entity7 / @entity6 are the focus of current clinical trials. SUMMARY: Risk stratification of @entity0 with @entity9 by age and/or history of @entity4 provides the basis of risk adapted therapeutic intervention. Aggressive control of modifiable cardiovascular risk factors, the use of antiplatelet agents, control of the hematocrit less than 45% in @entity11 vera, and cytoreductive therapy in high-risk @entity9 @entity0 is the focus of management. The exact role of @entity8 remains undefined and under active investigation, and the recent approval of @entity14 provides @entity0 with @entity11 vera a second-line option.

title: Contemporary approach to XXXX and @entity11 vera.

answer: @entity10


abstract: INTRODUCTION: Right @entity5 ( @entity5 ) is the most frequently observed complication occurring during cryoballoon ablation (CB). Our aim was to analyze the impact of the premature interruption (PI) of cryoenergy delivery in a large series of consecutive @entity0 during ablation in the right-sided veins on clinical outcome. METHODS AND RESULTS: All consecutive @entity0 having undergone second-generation CB ablation for paroxysmal @entity4 ( @entity4 ) from July 2012 to September 2014 were included in our analysis. Exclusion criteria were persistent @entity4 , presence of an intracavitary @entity3 , uncontrolled @entity2 , moderate or severe @entity1 , left atrium (LA) diameter >= 55 mm, and contraindications to general anesthesia. A total 287 consecutive @entity0 with drug-resistant paroxysmal @entity4 having undergone pulmonary vein isolation by means of CB technology (male 65%, age 57.6    13.1 years) were included. The incidence of @entity5 in the study population was 8.0% (23/287). At a mean follow-up of 11.5    3.9 months, the success rate without antiarrhythmic therapy was 81.6%. @entity0 with @entity5 had similar rates of @entity4 recurrence compared with those without @entity5 (17.4% vs. 17.8%; P = 0.9); the former had a mean follow-up of 10.9    3.7 months, the latter 11.8    4.5 months (P = 0.3). CONCLUSION: Conclusion: Our findings show that @entity0 in whom freezing was interrupted due to @entity5 had a similar outcome on 1-year follow-up compared with those in whom freezing cycles were completed in the septal veins. No baseline clinical or procedural characteristics were found to predict @entity4 recurrence in @entity0 having experienced @entity5 .

title: Impact on Clinical Outcome of Premature Interruption of Cryoenergy Delivery Due to Phrenic Nerve Palsy During Second Generation Cryoballoon Ablation for Paroxysmal XXXX .

answer: @entity4


abstract: BACKGROUND AND AIMS: Current endoscopic activity scores for ulcerative colitis (UC) do not take into account the extent of mucosal inflammation. We have developed a simple endoscopic index for UC that takes into account the severity and distribution of mucosal inflammation. METHODS: In this multicentre trial, UC @entity0 undergoing colonoscopy were prospectively enrolled. For the Modified Score (MS), the sum of Mayo Endoscopic Subscores (MESs) for five colon segments (ascending, transverse, descending, sigmoid and rectum) was calculated. The Extended Modified Score (EMS) was obtained by multiplying the MS by the maximal extent of inflammation. The Modified Mayo Endoscopic Score (MMES) was obtained by dividing the EMS by the number of segments with active inflammation. Colon biopsies were obtained from the rectum and sigmoid, as well as from all inflamed segments, by standard methods. Clinical activity was scored according to the Partial Mayo Score (PMS). Biological activity was scored according to @entity1 ( @entity1 ) and faecal calprotectin (FC) levels. Histological activity was scored according to the Geboes Score (GS). RESULTS: One hundred and seventy-one UC @entity0 (38% female, median age 47 years, median disease duration 13 years) were included. The MMES correlated significantly with the PMS (r = 0.535), @entity1 (r = 0.238), FC (r = 0.730) and GS (r = 0.615) (all p < 0.001). Median MMES scores were significantly higher in @entity0 with clinical, biological or histological activity (all p  <= 0.001) CONCLUSIONS: The MMES is an easy to use endoscopic index for UC that combines the severity analysis of the @entity2 with disease extent, and correlates very well with clinical, biological and histological disease activity.

title: The Modified Mayo Endoscopic Score (MMES): A New Index for the Assessment of Extension and Severity of Endoscopic Activity in Ulcerative Colitis XXXX .

answer: @entity0


abstract: UNASSIGNED: The @entity4 suppressor pathway is frequently inactivated in @entity0 @entity1 , enabling unrestrained proliferation. Most @entity1 , however, maintain expression of a wild-type (WT) @entity4 suppressor protein ( @entity5 ). It is generally in a hyperphosphorylated state (ppRB) because of mutations in upstream regulators such as @entity3 and cyclin D. Hyperphosphorylated ppRB is considered inactive, although data are emerging that suggest it can retain some function. To test the clinical relevance of @entity5 status, we obtained archival tissue sections from 91 cases of @entity6 resected between 2003 and 2008. All cases received @entity2 doublet chemotherapy, and the median survival was 5.9 years. All cases were assessed for @entity5 and ppRB using immunohistochemistry and quantified based on intensity of signal and proportion of positive cells. @entity5 expression was lost in 15% of @entity6 cases. In @entity1 that did not express @entity5 , the survival rate was significantly improved (hazard ratio, 0.21; 95% confidence interval, 0.06-0.69; P = .01) in comparison to @entity1 that express @entity5 . @entity5 status was found to be an independent predictor of overall survival on multivariate analysis (hazard ratio, 0.22; 95% confidence interval, 0.07-0.73; P = .01) along with increased stage and age. @entity5 status did not alter baseline levels of apoptotic or proliferative markers in these @entity1 , but the DNA damage response protein 53 @entity7 was higher in @entity1 with high levels of @entity5 . In summary, loss of @entity5 expression is associated with improved survival in @entity0 treated with surgical resection and chemotherapy. This may be useful in classifying @entity0 at greatest benefit for aggressive treatment regimes.

title: @entity4 tumor suppressor correlates with improved outcome in XXXX with @entity6 treated with surgery and chemotherapy.

answer: @entity0


abstract: PURPOSE: This study was conducted to evaluate the association between @entity5 and mental health status in the general Korean adult population and to investigate the relative burden of @entity5 on mental health using the @entity6 and Its Impact on Asthma ( @entity7 ) classification. METHODS: A cross-sectional study was performed by using data from 11,154 individuals, 19 years old or older in the Korean National Health and Nutrition Examination Survey 2011-2012. Univariate analysis was conducted in the healthy @entity5 groups with weighted prevalence of demographic characteristics, socioeconomic status, and comorbid diseases. Subanalysis that classified @entity5 severity according to the @entity7 classification was carried out to evaluate the relationship of @entity5 severity with mental health. The odds ratios (ORs) for each component representing mental health status were estimated by multiple logistic regression analysis with confounder adjustment. RESULTS: Univariate analysis with the chi-square test after adjustment for age, sex, body mass index, smoking status, @entity3 use status, and exercise status, components representing mental health status showed a linear relationship with the severity of @entity5 according to the @entity7 classification. Stress, @entity4 mood, suicidal thoughts, and psychological consultation factors were correlated with @entity5 after adjustment for demographic characteristics and socioeconomic status. Even after adjustment for comorbid @entity1 , the correlation remained significant with stress, @entity4 mood, and psychological consultation factors (OR [95% CI]; 1.227 [1.042, 1.445], 1.368 [1.095, 1.71], 1.804 [1.096, 2.969], respectively). CONCLUSIONS: @entity0 with @entity5 appear to be at higher risk of @entity2 in the general Korean adult population. Moreover, persistent or severe @entity5 was correlated with poor mental health. Therefore, better control of @entity5 may be conducive to better mental health, and more attention should be paid to the psychological status of @entity5 @entity0 .

title: Relationship Between XXXX and Mental Health in the General Korean Adult Population.

answer: @entity6


abstract: BACKGROUND: Acupuncture was shown to reduce symptoms of @entity1 ( @entity1 ). The present study investigated (a) whether autonomic function would differ in @entity1 @entity0 and healthy controls, and (b) whether acupuncture treatment would evoke changes in autonomic function compared to sham acupuncture. @entity0 AND METHODS: @entity1 @entity0 (n = 30) were recruited from a larger randomized controlled trial investigating the efficacy of acupuncture in @entity1 . 21 @entity0 received acupuncture, and 9 @entity0 received sham acupuncture. Among other we measured resting heart rate variability and cardiovascular reactivity to a cold pressure test prior to and after 12 sessions of acupuncture or sham acupuncture. In addition, 30 age- and sex-matched healthy controls were tested once. RESULTS: @entity1 @entity0 showed higher resting heart rate and lower heart rate variability as well as blunted cardiovascular responses compared to controls. After treatment, resting heart rate had decreased, and systolic blood pressure response to the cold pressure test had increased in @entity1 @entity0 . We found no significant differences in autonomic function changes between @entity0 receiving acupuncture or sham acupuncture. CONCLUSION: @entity1 @entity0 showed alterations in autonomic function, which had partially normalized after treatment. However, in this sample we found no specific effect of acupuncture compared to sham acupuncture.

title: Autonomic Function in XXXX and Acupuncture - an Experimental Pilot Study within a Randomized Trial.

answer: @entity1


abstract: OBJECTIVE: To identify the features of @entity1 associated with deterioration resulting in the need for surgical intervention or death. @entity0 AND METHODS: @entity0 with @entity1 who underwent cervical spine magnetic resonance imaging (MRI) between 1991 and 1996 were identified. @entity0 requiring immediate surgical intervention were excluded. The remainder were divided into two groups. Deterioration group: @entity0 requiring surgical intervention during the follow-up period and deaths resulting from cervical @entity2 . Conservative group: all other @entity0 . Relevant clinical features and radiology reports were extracted retrospectively from the casesheet. RESULTS: The deterioration group comprised 11 @entity0 (12%), median time to deterioration 15 months (range 4-84 months). The conservative group included 82 @entity0 . Initial clinical features did not differ significantly between the two groups. Sixty per cent of those @entity0 with compression or impingement at the atlanto-axial level on first MRI deteriorated over a median of 12 months (range 4-36 months). CONCLUSION: Deterioration is likely if there is evidence of cord compromise at the atlanto-axial level on MRI regardless of initial clinical and plain X-ray features.

title: Factors predictive of subsequent deterioration in XXXX .

answer: @entity1


abstract: A 55-year-old @entity1 visited our clinic for rapid swelling of her left breast. The left breast was palpated, and a mass of about 10 cm with thick skin, and multiple lymph nodes in the supraclavicle and axilla were found. PET-CT images showed an increased uptake in her left breast, lymph nodes, spine of TH5, sternum, left lobe of liver, and both lungs. The serum @entity3 markers were also found to be elevated. A core needle biopsy was performed, and the @entity3 was diagnosed as secondary inflammatory @entity4 ( @entity5 ). Immunohistochemical staining showed negative for @entity6 protein, but strongly positive for ER and @entity8 . @entity7 monotherapy administered her starting June, 2008. After 3 months, the @entity2 showed a notable response, which was subsequently maintained for 19 months. The @entity3 markers decreased to the normal range after 6 months, and the multiple @entity2 were not found by PET-CT after 1 year. A radiofrequency ablation operation was conducted on the remaining 3 cm @entity0 . Neoadjuvant endocrine therapy with @entity7 was shown to be useful for post-menopausal @entity0 @entity1 with strong hormone receptor expression.

title: [A case of secondary inflammatory @entity0 with multiple XXXX in which operation was possible through letrozole monotherapy].

answer: @entity2


abstract: BACKGROUND: Although non-adherence to antidepressant medications is a significant barrier to the successful treatment of @entity2 in clinical practice, few potentially modifiable predictors of poor adherence to antidepressant treatment are known. The aim of this study was to examine the relationship of psychological reactance, health locus of control and the sense of self-efficacy on adherence to treatment regimen among @entity1 outpatients with @entity2 . METHODS: One hundred and forty-five consecutive @entity1 outpatients suffering from @entity2 were invited to participate in a cross-sectional study and 119 accepted. @entity0 completed a series of self-reported questionnaires assessing psychological reactance, health locus of control, self-efficacy, and adherence to prescribed medication in addition to socio-demographic and clinical variables. Logistic regression analyses were performed to determine which factors better correlate to treatment adherence. RESULTS: Age was found to be the best correlate of adherence to prescribed treatment. As regards psychological dimension studied, medication adherence was negatively associated with both cognitive and affective psychological reactance; @entity0 with higher psychological reactance were more likely to be noncompliant than @entity0 showing a low level of psychological reactance. Regarding health locus of control, only the external dimension of doctor-attributed health locus of control was positively associated with medications adherence. No effect on adherence was observed for the self-efficacy scale. CONCLUSIONS: Psychological reactance is an important correlate of adherence to treatment in @entity0 with @entity2 and this needs to be considered when giving clinical advice in order to avoid inducing reactance and thus non-adherence to prescribed treatments. Mental health professionals need to learn about communication techniques and counseling skills that enable them to deal with the psychological reactance of their @entity0 .

title: The relationship of psychological reactance, health locus of control and sense of self-efficacy with adherence to treatment in XXXX outpatients with @entity2 .

answer: @entity1