abstract: We report a case of @entity9 in a 22-yr-old @entity0 , with an 11-yr history of poorly controlled Type 1 @entity1 complicated by laser-treated @entity8 , macroalbuminuria and severe @entity11 , also affected by @entity12 , @entity13 , @entity3 . She was admitted to our Hospital for @entity6 to the left thigh hindering her from walking. The @entity6 had appeared without @entity5 about 2 months before admission, and worsened progressively in spite of anti-inflammatory drugs. Clinical picture (localised tender mass without skin signs of @entity2 in an afebrile @entity0 ) and laboratory data (erythrocyte sedimentation rate 113 mm in 1 hr, fibrinogen 635 mg/dl) suggested the diagnosis of @entity9 . Magnetic resonance imaging (MRI) confirmed this hypothesis showing a hyperintense area in T2-weighted sequences at adductor muscle group with enhancement after intravenous contrast. Symptoms subsided over the following 4 weeks after bed rest, analgesics, @entity4 and a good glycaemic control. The 3-month follow-up MRI showed total recovery. At hospital admission, the @entity0 presented a very poor glycaemic control ( @entity10 c 15.5%). After discharge, she started--in order to avoid the weight gain associated with intensive insulin therapy--a daily intense isometric training, undergoing frequent hypoglycaemic episodes. In a few months, in spite of repeated laser treatment, @entity8 progressed to the proliferative stage with bilateral vitreous @entity7 and visual acuity decreased dramatically notwithstanding vitrectomy. This case confirms the association of @entity9 with poorly controlled long-standing @entity1 with microvascular complications, suggests the possible role of autoimmunity, and underlines the risk of repeated hypoglycaemic episodes and isometric exercise in the progression of @entity8 .

title: @entity9 associated with multiple autoimmune disorders, XXXX and a catastrophically poor glycaemic control: a case report.

answer: @entity12


abstract: UNASSIGNED: 533 Background: Preclinical data clearly demonstrated that cyclooxigenase activates growth-promoting and anti-apoptotic pathways as well as aromatase. However, data from clinical trial are poor, mainly due to the severe restrictions that the FDA has imposed to the @entity5 inhibitors in 2004 because of their serious adverse events. METHODS: We designed a phase III, placebo-controlled prospective trial in which postmenopausal @entity6 positive early @entity0 (EBC) @entity1 were randomized 1:1 to receive @entity7 (1 mg/die) upfront in combination with placebo or @entity8 (60 mg/die). Combined treatment was planned for 24 months. @entity1 were allowed to discontinue the @entity8 or placebo for @entity2 (censored). @entity7 was continued for 5 years. The primary end-point was the 5-years event free survival (EFS). The secondary end-point was to compare the risk of @entity3 and the muscle-skeletal events in the two groups. Chi-Square tests for categorical data and time to event provided two-sided p values. RESULTS: Since 2003 to 2006 we enrolled 182 @entity1 . A number of 93 @entity1 was enrolled in the treatment arm and N=89 in the control. The median treatment duration was 14 months in ETAN group and 12 in PAN group. A number of 37 @entity1 in the treatment arm and 33 in the control discontinued @entity8 after the FDA alert on @entity5 inhibitors. To a 5 years follow-up, the median EFS was 56.9 and 53.14 months [HR: 1.9; 95%CI (1.03 - 3.59), p= .03] in the treatment arm and control, respectively. There were no significative differences in terms of fractures [RR: 0.58, 95%CI (0.14-2.38), p= .45]. @entity4 was significative lower in the treatment arm (50/73) than the control (16/67) [RR: 2.1, 95%CI (1.29-3.43), p= .002]. None of the @entity1 in the treatment arm developed serious adverse event. CONCLUSIONS: Our data demonstrated a small but significative advantage in terms of EFS and muscle-skeletal events when @entity8 is added to @entity7 in adjuvant setting. Data are strongly limited from the study drop-out, but the very long follow-up and the absence of major @entity2 encourage larger phase III confirmatory trials.

title: @entity8 and XXXX in adjuvant early @entity0 : ETAN trial (phase III).

answer: @entity7


abstract: Various foot structures are thought to influence forefoot plantar pressures during walking. High @entity3 ( @entity3 ) during walking in @entity0 with @entity1 ( @entity1 ) and @entity4 ( @entity4 ) can cause skin breakdown. The question addressed by this study is "What are the primary forefoot structural factors that predict regional @entity3 during walking in groups of @entity0 with and without @entity1 and @entity4 ?" Twenty @entity0 with @entity1 and @entity4 (mean age 55+/-9 years, 6 female, 14 male, BMI=33+/-8) and 20 @entity0 without @entity1 , matched for gender, age, and BMI were tested. Measures of foot structure were taken from three-dimensional images constructed from spiral X-ray computed tomography. Peak plantar pressure data were recorded during walking. Hierarchical multiple regression analysis was used to predict regional @entity3 at the great toe and five metatarsal heads from selected structural and walking variables. Metatarsal phalangeal joint angle ( @entity2 ) was the most important variable predicting pressure, accounting for 19-45% of the @entity3 variance at five of the six locations in the @entity1 group. Soft tissue thickness, @entity6 , and forefoot @entity5 were the most important predictors of @entity3 in the control group. Combinations of structural and walking variables accounted for 47-71% of the variance in the @entity1 group and 52-83% of the variance of @entity3 during walking in the control group. These structural variables, especially @entity2 , should be considered in attempts to develop strategies to reduce excessive forefoot @entity3 that may contribute to skin breakdown or other injury.

title: Forefoot structural predictors of plantar pressures during walking in @entity0 with @entity1 and XXXX .

answer: @entity4


abstract: OBJECTIVE: To investigate the relationship between awareness of @entity4 and psychological well-being in a nonclinically @entity2 sample of @entity0 with mild to moderate @entity1 ( @entity1 ). METHODS: Study @entity0 (N  = 104) enrolled through Columbia University Medical Center and the University of Pennsylvania completed clinical and cognitive assessments. @entity0 were rated with regard to their degree of @entity4 and completed questionnaires relating to their psychological well-being, including mood and quality of life (QOL). Mediating models were used to establish the relationship between awareness, @entity2 , and QOL and to examine potential mediators of awareness and @entity2 , including @entity3 , objective @entity4 , and negative self-ratings. RESULTS: There was a direct association between @entity4 and @entity2 mood but not awareness and QOL. However, there was an indirect association between awareness and QOL through @entity2 . Neither @entity3 , @entity4 , nor negative self-ratings mediated the relationship between awareness and @entity2 . CONCLUSION: Awareness is associated with @entity2 mood in nonclinically @entity2 @entity0 with mild to moderate @entity1 . However, @entity2 mood does not appear to reflect the direct psychological reaction to awareness of @entity4 . Moreover, awareness has only an indirect association with QOL via @entity2 mood. These results suggest that preserved awareness does not have a direct negative impact on overall psychological well-being in @entity1 .

title: Examining the Pathways between Self-Awareness and Well-Being in Mild to  Moderate XXXX .

answer: @entity1


abstract: PURPOSE: Visual search plays an integral role in many daily activities. This study aimed to determine whether @entity0 with @entity2 are slower than visually healthy age-matched individuals when searching for items in computer displayed images. METHODS: Forty @entity0 were recruited for the study: 20 @entity0 with a clinical diagnosis of @entity2 and 20 age-similar visually healthy control subjects. All @entity0 had visual acuity of 6/12 or better. @entity0 were presented with 20 images with Landolt C symbols and 15 photographic images of everyday scenes on a computer. The time taken by each @entity0 to locate a specified item in each image was recorded. Average search times were calculated across @entity0 and compared between groups. RESULTS: All the @entity0 had @entity1 in both eyes. On average, the @entity0 also differed from control subjects by binocular contrast sensitivity measurements (p = 0.01) and visual acuity (p = 0.003). The @entity0 (mean age = 67 years, S.D.: 10 years) and controls (mean age: 67 years, S.D.: 11 years) were age similar (p = 0.40). The median search time for @entity0 finding target items in photographs of everyday scenes was 15.2 s (interquartile range 9.4-20.6 s) and this was significantly slower than the median time (10.0 s; interquartile range 7.2-10.3 s) taken by the controls (p = 0.007). There was no statistical evidence for a difference in median search times between groups in the Landolt C search task (p = 0.24). CONCLUSION: Some individuals with @entity1 in both eyes find it especially difficult to locate objects in photographs of everyday scenes when compared to visually healthy individuals of a similar age.

title: An exploratory study of visual search performance in XXXX .

answer: @entity2


abstract: A series of 212 prostate specimens of @entity0 dead between August 2002-August 2004, have been sectioned in consecutive autopsies and subjected to whole mount analysis in purpose to determine the epidemiology of @entity3 in Greece. @entity3 were found in 40 cases (18.8%) most in the peripheral region. In all, 29 of 40 impalpable @entity1 (70.7%) had volume less than 1 cm3. Most of impalpable @entity2 were of favorable (Gleason score 2-4) or intermediate (Gleason score 5 and 6) histological type (55 and 27.7%, respectively) while only five (12.5%) were undifferentiated (Gleason score 7 and 8). In all, 24 (60%) of the 40 impalpable @entity2 were multifocal and consisted of two or more foci, most of small size (<0.5 cm3). Most of the impalpable @entity1 found in this autopsy study were potentially insignificant @entity1 (relatively low volume, favorable or intermediate histological pattern and absence of invasiveness). @entity5 ( @entity5 ) coexisted with impalpable @entity2 , in almost half of the @entity1 -positive specimens. There was a positive correlation between @entity5 foci and coexistent @entity1 foci in most of the cases. Frequency rate and pathological features of both entities show significant variations in medical literature. Since the incidence of @entity3 in Greece is relatively low, and according to our autopsy findings, it is plausible that the frequency of @entity3 in a certain population could be related to the prevalent model of impalpable @entity1 as well as to the frequency and extend of the @entity4 .

title: Frequency of @entity3 and XXXX in Greek male population: an autopsy study.

answer: @entity4


abstract: OBJECTIVES: To report our experience of subacute @entity1 (SANS), an unusual lesion of the minor salivary palatal glands, and to discuss its relationship with @entity1 sialometaplasia (NS). DESIGN: A retrospective review of records for @entity0 with SANS identified between 1996 and 2001. SETTING: @entity6 center, referral center, and an ambulatory care center. @entity0 : Three @entity0 (1 @entity0 , 2 @entity0 ), aged 22, 23, and 40 years at diagnosis. INTERVENTION: All 3 @entity0 underwent incisional biopsy. MAIN OUTCOME MEASURES: Clinical description of SANS, ability to make the diagnosis preoperatively, clinical evolution, histologic features, and comparison with the much more frequent NS. RESULTS: Three @entity0 presented with a lateral palatal nodule (1 case bilateral, 1 case ulcerated) of 7 to 10 days' duration, 0.8 to 1.0 cm in size, slightly or not painful. No @entity0 was correctly diagnosed prior to undergoing a biopsy. In all 3 cases, the biopsy specimen showed acinic @entity1 surrounded by a dense polymorphous inflammatory infiltrate with @entity3 of ductal cells but no @entity5 . Healing occurred without any further treatment in up to 3 weeks. No recurrence was observed in 2 cases; 1 @entity0 was lost to follow-up. CONCLUSIONS: SANS is a @entity2 of the palatal salivary glands, easily misdiagnosed preoperatively. The main differences from NS are smaller size of lesion, scarcity of @entity4 , and absence of @entity5 . Although initially described as a new autonomous entity, SANS might be an early or minimal form of NS.

title: @entity1 : a form of XXXX sialometaplasia?

answer: @entity1


abstract: BACKGROUND: Cast immobilisation after successful closed reduction is a standard treatment for displaced extra-articular @entity1 of lower end radius. The position of the wrist during immobilisation is controversial. Immobilisation in dorsiflexion prevents redisplacement after closed reduction. Our aim is to determine the effectiveness of immobilization of wrist in dorsiflexion in such cases and evaluate anatomical and functional outcome. MATERIALS AND METHODS: Study included 54 @entity0 , above 19 years of age with closed extra-articular @entity1 of lower end radius treated conservatively with below elbow cast application. The wrist was maintained in 15   of dorsiflexion during plaster immobilisation. At 24 weeks, functional results were evaluated with subjective symptoms and objective signs, as per modified Demerit Point Score System. Anatomical result was evaluated based on the scheme devised by Lidstrom (1959) and modified by Sarmiento et al. (1980). RESULTS: 76% @entity0 had Excellent to Good subjective symptoms. Out of 42 @entity0 that had residual dorsal angulation of less than 10  , 37 had excellent to good functional outcome. 39 of the 43 @entity0 who had loss of radial length less than 6  mm had excellent to good functional outcome. 40 out of 49 @entity0 having loss of radial angulation less than 9   showed excellent to good functional outcome. Functional result was directly proportional to anatomical outcome. CONCLUSION: Cast immobilization of extra articular @entity1 of lower end radius with wrist in dorsiflexion prevents re-displacement of the fragments resulting in satisfactory anatomical _ functional outcome.

title: Immobilisation of extra-articular distal radius XXXX (Colles type) in dorsiflexion. The functional and anatomical outcome.

answer: @entity1


abstract: Energy intake restriction reduces bone formation both in protein-energy malnourished @entity0 and in undernourished @entity1 , and such conditions might cause partial or irreversible @entity3 . Because the use of anti-resorptive agents in this situation is seemingly limited, we examined the effect of the anabolic agent, recombinant @entity0 parathyroid hormone (rhPTH(1-84)), on bones in undernourished conditions. First, the osteopenic changes of @entity1 bones with 40% restricted diet for 4 weeks were confirmed. Subsequently, another set of the @entity1 were randomized into four groups and studied for 8 weeks: the freely fed group (control group); the restricted diet, then freely fed group (restriction-ad libitum group); the restricted diet-vehicle-treated group (restriction-vehicle group); and the restricted diet- @entity4 -treated group (restriction- @entity4 group). In the restriction-vehicle group, total femoral @entity2 ( @entity2 ) was lower and femoral length was shorter than the control group by 15.4% and 8.1% respectively (P<0.05). In the restriction-ad libitum group, these parameters recovered fully to those of the control group. In the case of intermittent @entity4 treatment in the persistent undernourished state, the @entity2 of total femur caught up with those of the control or the restriction-ad libitum group. However, the femoral length remained shorter than those of the other groups. Serum @entity5 was significantly reduced in continuously undernourished @entity1 , whereas it was elevated in the restriction- @entity4 group. In conclusion, @entity2 of total femur was low in undernourished @entity1 . However, it increased after re-feeding ad libitum or intermittent @entity4 treatment. We suggest that rhPTH(1-84) may be a possible therapeutic agent for ongoing @entity3 , especially in @entity0 in a chronically undernourished condition.

title: The effects of recombinant XXXX parathyroid hormone, rhPTH(1-84), on bone mass in undernourished @entity1 .

answer: @entity0


abstract: BACKGROUND: Reperfusion causes injury to the coronary artery endothelium primarily by neutrophil-mediated mechanisms. However, factors other than neutrophils may govern the extent of @entity3 . This study tests the hypothesis that gradual initiation of reflow will reduce reperfusion injury and preserve postischemic endothelial function. METHODS: In 16 anesthetized @entity2 , the left anterior descending artery was ligated for 60 minutes. In one group, reperfusion was initiated abruptly (abrupt, n = 8), whereas in the gradual reperfusion group (ramp, n = 8), flow was slowly initiated during the first 30 minutes of reperfusion. After reperfusion, coronary artery segments were isolated to assess postischemic endothelial function. RESULTS: Infarct size (area of @entity0 /area at risk) was significantly reduced in the ramp group (28.2% +/- 2.0%) compared with abrupt (41.6% +/- 1.4%). Neutrophil accumulation ( @entity9 ) in the area at risk was significantly greater in the ramp group compared with abrupt (8.0 +/- 1.3 versus 3.5 +/- 0.8 U/g tissue). In isolated postischemic left anterior descending arterial rings, the concentration of @entity5 that elicited a response 50% of the maximum possible response was significantly greater in abrupt (-6.88 +/- 0.04 log [mol/L]) than ramp (-7.62 +/- 0.04 log [mol/L]) and control (-7.68 +/- 0.003 log [mol/L]), suggesting @entity4 . The concentration of @entity7 that elicited a response 50% of the maximum possible response was similarly greater in abrupt (-7.24 +/- 0.03 log [mol/L]) versus ramp (-7.62 +/- 0.03 log [mol/L]) and control (-7.8 +/- 0.04 log [mol/L]). Smooth @entity1 (response to @entity8 ) also occurred in the abrupt rings. CONCLUSIONS: Gradual reperfusion of an ischemic area reduces @entity6 size and preserves endothelial function but paradoxically increases neutrophil accumulation within the area at risk.

title: Gradual reperfusion reduces XXXX size and endothelial injury but augments neutrophil accumulation.

answer: @entity6


abstract: UNASSIGNED: Three combinations of molecular chaperones from @entity0 , i.e., DnaK-DnaJ-GrpE- @entity4 - @entity5 , @entity4 - @entity5 and DnaK-DnaJ-GrpE, were overproduced in @entity3 , and their in vitro stabilizing effects on a @entity2 hydratase (NHase) were assessed. The optimal gene-combination, @entity0 @entity4 - @entity5 (ecgroEL-ES), were introduced into Rhodococcus ruber TH3. A novel engineered strain, R. ruber TH3G was constructed with the native NHase gene on its chromosome and the heterologous ecgroEL-ES genes in a shuttle plasmid. In R. ruber TH3G, NHase activity was enhanced 37.3% compared with the control, TH3. The in vivo stabilizing effect of ecGroEL-ES on the NHase was assessed using both @entity1 immersion and heat shock experiments. The inactivation behavior of the in vivo NHase after immersion in a solution of dynamically increased concentrations of @entity1 was particularly evident. When the @entity1 concentration was increased to 500 g/L (50%), the remaining NHase activity in TH3G was 38%, but in TH3, activity was reduced to 10%. Reactivation of the in vivo NHases after varying degrees of inactivation was further assessed. The activity of the reactivated NHase was more than twofold greater in TH3G than in TH3. The hydration synthesis of @entity1 catalyzed by the in vivo NHase was performed with continuous acrylonitrile feeding. The final concentration of @entity1 was 640 g/L when catalyzed by TH3G compared with 490 g/L @entity1 by TH3. This study is the first to show that the chaperones ecGroEL-ES work well in Rhodococcus and simultaneously possess protein-folding assistance functions and the ability to stabilize and reactivate the native NHases.

title: Overproduction of the @entity0 chaperones @entity4 - XXXX in Rhodococcus ruber improves the activity and stability of cell catalysts harboring a @entity2 hydratase.

answer: @entity5


abstract: The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced @entity1 ( @entity1 ). @entity0 (pts) with locally advanced or metastatic @entity1 treated with first-line palliative chemotherapy were included. Among others, the serum markers CYFRA 21-1, @entity3 , @entity4 ( @entity4 ), and 25-OH vitamin D3 were determined at baseline and categorized by pre-defined cut-offs [median values (MV), upper limits of normal (ULN), lower limits of normal (LLN), or the natural logarithm (ln)] and correlated with @entity2 ( @entity2 ). Among the 59 pts included, pre-treatment CYFRA 21-1 levels showed a strong correlation with @entity2 independent of the applied cut-off (MV 4.9  ng/ml-14.2 vs. 4.2 months, HR 0.18, p   =   0.001; ULN 3.3  ng/ml-14.2 vs. 4.4 months, HR 0.28, p   =   0.003; [ln] CYFRA 21-1-HR 0.77, p   =   0.013). Lower values of @entity3 were additionally associated with an improvement in @entity2 (categorized by LLN of 2.05  g/l-10.4 vs. 5.5 months, HR 0.46, p   =   0.023; [ln] @entity3 -HR 0.51, p   =   0.036). Pts with baseline @entity4 values below the MV of 22  mg/l also had a prolonged @entity2 (10.4 vs. 5.0 months, HR 0.47, p   =   0.036). For 25-OH vitamin D3 levels, no significant correlation with @entity2 was found. In multivariate analyses, pre-treatment CYFRA 21-1 levels (categorized by MV-HR 0.15, p   =   0.032) as well as [ln] @entity3 (HR 0.30, p   =   0.006) retained their independent prognostic significance for @entity2 . CYFRA 21-1, @entity3 , and @entity4 might provide useful prognostic information in advanced @entity1 . An external multicenter validation of these results is necessary.

title: Assessing novel prognostic serum biomarkers in advanced @entity1 : the role of CYFRA 21-1, serum amyloid A, XXXX , and 25-OH vitamin D3.

answer: @entity3


abstract: The accumulation of 125I-low density lipoprotein (LDL) into normal and @entity1 arterial tissue and cellular uptake in arterial cells were studied in an in vitro perfusion system for @entity0 aorta. The accumulation of 125I-LDL in normal tissue could be fitted to an inverse exponential function with an initial influx rate of 1.39 nl/mg wet weight/hour and an equilibration volume of about 2% of the tissue volume. The influx rate into @entity1 was about 10 times faster and the equilibration volume, 50 times higher. In @entity1 tissue there was a steep concentration gradient between the plaque and the underlying media. The accumulation of 125I-LDL in the media under plaque and in normal tissue adjacent to plaques was similar to that seen in normal tissue. For studies of cellular uptake of LDL a trace label, 125I- @entity2 - @entity3 (TC), was used. Normal or @entity1 @entity0 aorta was perfused in vitro with medium containing 125I-TC-LDL. After perfusion the tissue was digested and the cells were isolated by density gradient centrifugation. Two main cell fractions with characteristics of smooth muscle cells and foam cells, respectively, were obtained. A 70-fold higher uptake was seen in the foam cells. In conclusion, these studies suggest a higher influx rate into @entity1 , as well as a high LDL concentration in the plaque, compared with normal tissue or underlying media. We suggest that most of the cellular uptake of LDL in the arterial wall is caused by the foam cells.

title: Influx and cellular degradation of low density lipoproteins in XXXX aorta determined in an in vitro perfusion system.

answer: @entity0


abstract: BACKGROUND: Mortality in @entity5 @entity1 both from natural and non-natural causes was reported to be markedly higher than in the general population. The effect of the @entity5 hospital (PH) closure process on mortality has nonetheless seldom been investigated. We studied mortality in a cohort of PH @entity1 , taking into account the closure process in Italy. METHODS: A total of 2915 @entity1 from 12 PH were described in the period 1994-1996 and followed up until June 2000, and discharges and @entity6 were registered. Standardized mortality ratios (SMR) for natural and non-natural causes were computed on the basis of regional death rates. RESULTS: Observed @entity6 were 714 vs. 291.2 expected. The all-causes SMR was 2.47 in males and 2.43 in females. The SMR was 26.92 in males and 13.75 in females for @entity5 causes, 6.84 and 7.89 for undefined causes, 9.57 and 7.27 for @entity4 , 6.38 and 7.78 for @entity8 , and 1.27 and 1.58 for @entity7 . No excess was observed for all @entity3 in males, but the SMR was 1.50 for @entity2 in males, 2.30 for @entity0 and 1.48 for all @entity3 in females. SMR for suicide was 3.85 in males and 2.73 in females. Most SMR were higher at younger age, although the rate of absolute excess @entity6 was greater above age 60. The SMR for all causes was 2.66 before discharge from PH, and 2.09 after discharge. CONCLUSIONS: Mortality remained high after leaving the PH, but no increase was associated to the PH closure.

title: Mortality in long-stay @entity1 from XXXX hospitals in Italy--results from the Qualyop Project.

answer: @entity5


abstract: OBJECTIVE: To systematically review evidence for the efficacy of family-based education for @entity2 ( @entity2 ) @entity0 and carers. METHOD: A systematic review was conducted. Databases CINAHL, MEDLINE Complete, Cochrane, PubMed, Web of Science, EMBASE, PsycINFO, and Scopus were searched between 1 January 2005 and 1 May 2015. Randomised controlled trials included @entity2 @entity0 and carer dyads or carers alone. The primary outcome was @entity2 knowledge. Secondary outcomes included self-care behaviour, dietary and treatment adherence, quality of life, @entity1 , perceived control, hospital readmissions, and carer burden. RESULT: Six trials reported in nine papers were included. Wide variation in the quality of the studies was found. Two studies only examined @entity2 knowledge; a significant improvement among @entity0 and carers was reported. Other significant findings were enhanced @entity0 self-care, boosted dietary and treatment adherence, enriched @entity0 quality of life, improved perceived control among @entity0 but not carers, and reduced carer burden CONCLUSION: Modest evidence was found for family-based education among @entity2 @entity0 and carers. Methodological shortcomings of trials signify the need for empirically sound future research. PRACTICE IMPLICATION: Family-based @entity2 education needs to include strategies that are tailored to the @entity2 @entity0 and carer, and sustainable in nature.

title: XXXX family-based education: a systematic review.

answer: @entity2


abstract: The incidence of @entity2 ( @entity2 ) in 363 adult renal transplant recipients transplanted during the period 1990-96 has been analysed. UTI occurred in 96 @entity0 (26%), most frequently during the first year after transplantation. Female recipients had significantly more UTI than male recipients (49% vs. 14%, p < 0.0001). There was no difference in the incidence of UTI between recipients receiving @entity5 -tail catheters as ureteral stents or not, the figures being 21% vs. 28%, respectively. Age had no influence on the incidence of UTI. In 341 @entity0 treated with @entity1 the incidence of UTI was 28%, while in 15 @entity0 treated with @entity4 only 1 @entity0 (7%) had a UTI (ns). The majority of organisms cultured were gram-negative (76%), with approximately 1/3 being @entity3 and 1/5 being Enterococcus and Klebsiella/Enterobacter. The bacterial spectrum was not influenced by the recipient's age. UTI had no effect on the number of rejections, or on graft and @entity0 survival in living donor transplant recipients. No significant difference was found in graft and @entity0 survival rates at 3 yr between @entity0 who had UTI or no UTI.

title: XXXX following renal transplantation.

answer: @entity2


abstract: OBJECTIVE: To review the effectiveness of interventions targeted at health care professionals and/or the structure of care in order to improve the management of @entity1 in primary care, outpatient, and community settings. RESEARCH DESIGN AND METHODS: A systematic review of controlled trials evaluating the effectiveness of interventions targeted at health care professionals and aimed at improving the process of care or @entity0 outcomes for @entity0 with @entity1 was performed. Standard search methods of the Cochrane Effective Practice and Organization of Care Group were used. RESULTS: A total of 41 studies met the inclusion criteria. The studies identified were heterogeneous in terms of interventions, @entity0 , settings, and reported outcomes. In all studies, the interventions were multifaceted. The interventions were targeted at health care professionals only in 12 studies, at the organization of care only in 9 studies, and at both in 20 studies. Complex professional interventions improved the process of care, but the effect on @entity0 outcomes remained less clear because such outcomes were rarely assessed. Organizational interventions that facilitated the structured and regular review of @entity0 also showed a favorable effect on process measures. Complex interventions in which @entity0 education was added and/or the role of a nurse was enhanced led to improvements in @entity0 outcomes as well as the process of care. CONCLUSIONS: Multifaceted professional interventions and organizational interventions that facilitate structured and regular review of @entity0 were effective in improving the process of care. The addition of @entity0 education to these interventions and the enhancement of the role of nurses in @entity1 care led to improvements in @entity0 outcomes and the process of care.

title: Interventions to improve the management of XXXX in primary care, outpatient, and community settings: a systematic review.

answer: @entity1


abstract: The goal of this study is to determine the feasibility of intravenous @entity2 and an intraperitoneal @entity7 agent in the treatment of @entity0 with @entity1 . We performed a retrospective chart review of @entity0 with primary, persistent or recurrent @entity1 , who received intravenous @entity2 and an intraperitoneal @entity7 agent. @entity0 received @entity2 (750 mg/m  ) intravenous on days 1 and 8 and @entity6 (100 or 60 mg/m  ) intraperitoneal on day 1 every 21 - 28 days. An alternate regimen was composed of @entity2 (750 mg/m  ) intravenous and @entity9 (AUC 5) intraperitoneal on day 1 every 21 days. Dose reductions occurred at the discretion of the prescribing physician.Intravenous @entity2 and an intraperitoneal @entity7 agent were administered to 12 @entity0 with advanced primary or recurrent @entity1 . Myelosuppression was the most common @entity3 . Grade 3 or 4 @entity5 , @entity8 and @entity4 occurred in 7, 8 and 2 @entity0 respectively. Dose reductions were required in 7 of 12 @entity0 . 10 of 12 @entity0 received 6 cycles of the regimen. Treatment was discontinued prior to 6 cycles in 2 of 12 @entity0 secondary to progression in one case and to grade 4 @entity8 and @entity5 in another.The combination of intravenous @entity2 and an intraperitoneal @entity7 agent appears to be a feasible regimen in @entity0 with @entity1 . The most common @entity3 was myelosuppression, which resulted in dose reductions in almost half of the @entity0 .

title: Feasibility of intravenous @entity2 and an intraperitoneal @entity7 agent in the treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: We compared the sonographic characteristics of @entity7 with pathologic findings. METHODS: Information over 10 years was collected on 12 @entity0 (six @entity0 , six @entity0 ; mean age = 47 years) with surgically proven @entity7 . Clinical data, sonographic features, and histopathologic findings were reviewed. RESULTS: The @entity1 in males were smaller and simpler than those in @entity0 (p < 0.05, Fisher's exact test). Four of the six larger @entity1 (>5 cm) showed mixed-echoic patterns corresponding with pathologically intratumoral @entity4 and @entity2 . Four homogeneously @entity1 had less change in @entity1 composition. Three homogeneously @entity1 had evident fatty changes inside. One @entity1 had a hypoechoic rim, that correlated mostly to the @entity1 itself and compressed @entity3 . Seven of the 12 @entity1 had thin fibrous capsules that were not seen on sonography. CONCLUSION: @entity7 have variable sonographic appearances depending on changes in the @entity1 . Hypoechoic, hyperechoic, and mixed-echoic patterns represent simple @entity5 , @entity5 with @entity6 , and @entity4 , respectively, in @entity1 .

title: Sonographic features of XXXX with pathologic correlation.

answer: @entity7


abstract: OBJECTIVE: Atrial contribution to ventricular filling was studied to assess its role in predicting the future development of @entity1 ( @entity1 ) in @entity0 with severe @entity3 ( @entity3 ) and sinus rhythm. DESIGN: Two hundred and eight @entity0 with severe @entity3 and sinus rhythm were followed up for 1 year. Baseline data were compared between group I (who developed @entity1 at follow-up) and group II (who maintained sinus rhythm). Left atrial size, severity of @entity3 , @entity2 ( @entity2 ) of mitral valve flow and @entity2 due to atrial systole (A- @entity2 ) were noted. Percentage contribution of A- @entity2 to the total @entity2 (A-%) was calculated. Sensitivity and specificity of A-% to predict the onset of @entity1 was obtained. RESULTS: Left atrial size, severity of @entity3 and total @entity2 were similar in the two groups. Group I @entity0 were older (31.1 +/- 9.1 and 18.4 +/- 6.5 years, respectively, p < 0.03) with smaller A- @entity2 (5.3 +/- 2.2 and 6.7 +/- 3.4 cm, respectively, p < 0.01) and A-% (8.9 +/- 1.8 and 11.2 +/- 2.7, respectively, p < 0.003). A-% of <9% (mean value of A- @entity2 in group I) had high sensitivity (84%, positive predictive value 76%) and specificity (80%, negative predictive value 87%) to predict the development of @entity1 . CONCLUSION: Atrial contribution to ventricular filling is reduced in @entity0 prone to develop @entity1 (due to inefficient left atrial contraction, much before its dilatation). It can be used for early identification of @entity0 likely to develop @entity1 with high sensitivity and specificity. It is simple, easily available, cost-effective and will guide earlier intervention and more frequent follow-up. There is a preclinical loss in atrial pump function much before the eventual onset of @entity1 .

title: Prediction of @entity1 in XXXX with severe @entity3 --role of atrial contribution to ventricular filling.

answer: @entity0


abstract: @entity9 is the prototype marker of @entity1 and has been shown to predict mortality in hemodialysis @entity0 . However, it remains uncertain as to whether a single @entity9 level has similar prognostic significance in peritoneal dialysis @entity0 . A single high-sensitivity @entity9 (hs-CRP) level was measured in 246 continuous ambulatory peritoneal dialysis @entity0 without active infections at study baseline together with indices of dialysis adequacy, echocardiographic parameters (left ventricular mass index, left ventricular dimensions, and ejection fraction), nutrition markers (serum albumin, dietary intake, and subjective global assessment) and biochemical parameters (hemoglobin, lipids, @entity4 , and @entity7 ). The cohort was then followed-up prospectively for a median of 24 mo (range, 2 to 34 mo), and outcomes were studied in relation to these parameters. Fifty-nine @entity0 died (36 from cardiovascular causes) during the follow-up period. The median hs-CRP level was 2.84 mg/L (range, 0.20 to 94.24 mg/L). @entity0 were stratified into tertiles according to baseline hs-CRP, namely those with hs-CRP < or = 1.26 mg/L, 1.27 to 5.54 mg/L, and > or = 5.55 mg/L. Those with higher hs-CRP were significantly older (P < 0.001), had greater body mass index (P < 0.001), higher prevalence of @entity3 (P = 0.003), and greater left ventricular mass index (P < 0.001). One-year overall mortality was 3.9% (lower) versus 8.8% (middle) versus 21.3% (upper tertile) (P < 0.0001). @entity2 rate was 2.7% (lower) versus 5.2% (middle) versus 16.2% (upper tertile) (P < 0.0001). Multivariable Cox regression analysis showed that every 1 mg/L increase in hs-CRP was independently predictive of higher all-cause mortality (hazard ratio [ @entity5 ], 1.02; 95% CI, 1.01 to 1.04; P = 0.002) and @entity2 ( @entity5 , 1.03; 95% CI, 1.01 to 1.05; P = 0.001) in peritoneal dialysis @entity0 . Other significant predictors for all-cause mortality included age ( @entity5 , 1.07; 95% CI, 1.04 to 1.10), gender ( @entity5 , 0.49; 95% CI, 0.27 to 0.90), @entity6 ( @entity5 , 2.65; 95% CI, 1.46 to 4.80), left ventricular mass index ( @entity5 , 1.01; 95% CI, 1.00 to 1.01) and residual GFR ( @entity5 , 0.53; 95% CI, 0.38 to 0.75). Age ( @entity5 , 1.06; 95% CI, 1.02 to 1.10), history of @entity5 ( @entity5 , 3.31; 95% CI, 1.36 to 8.08), @entity6 ( @entity5 , 3.20; 95% CI, 1.43 to 7.13), and residual GFR ( @entity5 , 0.57; 95% CI, 0.38 to 0.86) were also independently predictive of @entity2 . In conclusion, a single, random hs-CRP level has significant and independent prognostic value in @entity8 @entity0 .

title: Is a single time point XXXX predictive of outcome in peritoneal dialysis @entity0 ?

answer: @entity9


abstract: UNASSIGNED: @entity6 ( @entity6 ) are an infrequent cause of @entity4 in oncological @entity0 . The majority are di-agnosed in @entity0 with advanced @entity1 , above all localized in the breast, lung or stomach. There are few published cases involving @entity0 with @entity1 . We present the case of a 69 year-old male, without a previous diagnosis of @entity1 , who was admitted due to subacute @entity4 , with clinical suspicion of @entity3 ( @entity3 ). The @entity0 died on the fifth day of admission. The autopsy confirmed the existence of a @entity1 in the left renal pelvis with hepatic and lymphoganglionary metastasis and an extensive @entity3 that affected a large part of the capillaries and medium-caliber blood vessels of both lungs. @entity6 were considered responsible for the progressive @entity5 and as the final cause of @entity2 . The most frequent clinical presentation of @entity6 is @entity4 . They are often mistaken for @entity3 and diagnosis is not easy. Their prognosis is very bad, with extremely high mortality and confirmation is usually post-mortem.

title: [Microvascular XXXX in a @entity0 with @entity1 ].

answer: @entity6


abstract: UNASSIGNED: @entity2 stem cells (LSCs) are regarded as the origin of @entity2 and its recurrence. Side population (SP) cells possess some intrinsic stem cell properties and contain numerous LSCs. In this study, we examined the prognostic significance of cluster differentiation 47 (CD47) and identified the appropriate target for eliminating LSCs. We determined the percentage of SP cells in a @entity1 cell population and analyzed CD47 expression in different cell subsets. We then explored whether CD47 affected the phagocytic ability of macrophages to LSCs in vitro. Finally, the effect of anti-CD47 monoclonal antibodies, alone or combination with @entity3 , against @entity2 cells was evaluated in vitro and in vivo to identify the optimal targets for the treatment of @entity2 . We observed an SP sub-fraction at low frequency (1.81    0.99%), which was a likely candidate for LSC enrichment. CD47 was more highly expressed on @entity1 LSCs (P < 0.05) and was an independent predictor of survival and refractory disease in @entity1 -engrafted @entity0 . Furthermore, the anti-CD47 monoclonal antibody stimulated preferential phagocytosis of LSCs by macrophages in vitro. Finally, single or combination treatment of @entity1 LSC-engrafted @entity0 with @entity3 and anti-CD47 antibody resulted in targeting of LSCs and depletion of @entity2 cells. These findings suggest that CD47 is an antibody target in LSCs and combination treatment with @entity3 and anti-CD47 monoclonal antibody represents an attractive option for the therapeutic targeting of @entity4 .

title: @entity3 and anti-CD47 antibody combination therapy eliminates XXXX @entity1 cells in vivo and in vitro.

answer: @entity4


abstract: UNASSIGNED: Conditions such as @entity3 ( @entity3 ) and @entity6 ( @entity6 , such as @entity8 , PsA, and @entity6 , @entity10 ) are characterized by an imbalance between osteoclast (OC) bone resorption and osteoblast (OB) bone formation. The two conditions present substantial differences in bone involvement, which is probably related to the different expression of @entity7 and @entity4 , two cytokines that strongly promote osteoclastogenesis and focal @entity2 . @entity4 is the major inflammatory cytokine in @entity3 . It acts by both triggering OC bone erosion via the @entity9 system, and suppressing OB bone formation through the overexpression of @entity11 , a powerful inhibitor of the WNT bone anabolic signaling pathway. Differing from @entity4 , @entity7 promotes also osteogenesis, particularly at inflamed sites undergoing mechanical stress, such as entheses. Therefore, in @entity3 , where overexpression of @entity4 is higher than @entity7 , OC bone resorption largely prevails upon bone formation. In PsA and @entity10 , the prevailing inflammatory cytokine is @entity7 , which promotes also osteogenesis. Given the prevalent involvement of entheses poor of OC, excess bone formation may even prevail over excess bone resorption. The results of clinical trials support the different pathophysiology of bone involvement in chronic @entity5 . Inflammation control through anti- @entity4 agents has not resulted in incomparable effects on radiographic progression and excess bone formation in both @entity10 and PsA. Clinical trials investigating @entity7 inhibitors, such as secukinumab, in @entity0 with @entity8 are underway. The preliminary results on @entity1 and symptoms appear positive, while long-term studies are required to demonstrate an effect on excess bone formation.

title: Focal bone involvement in inflammatory @entity5 : the role of XXXX .

answer: @entity7


abstract: OBJECTIVE: @entity8 ( @entity8 ) is a disorder characterized by tubular dilation of renal collecting ducts and cystic dilation of medullary pyramids that has been associated with stone disease. The significance of @entity4 and the mechanisms by which it occurs are incompletely understood. We describe clinical and metabolic features of @entity4 in a cohort of @entity0 with @entity8 . METHODS: Records were reviewed of 56 @entity0 , all with radiographic diagnosis of @entity8 and data collected pertaining to presentation, stone events and recurrences, stone composition, and metabolic profile to perform a descriptive study with median 3.7 years follow-up. RESULTS: @entity4 was confirmed radiographically in 39/56 @entity0 (69.6%). No @entity0 without evidence of @entity4 developed a stone event, whereas 13/39 (33%) of those with @entity4 developed a recurrent stone event. Stones were composed of @entity5 , @entity5 , @entity1 apatite, and @entity2 . Metabolic profile was obtained for 26 of 39 (67%) stone-forming @entity0 demonstrating abnormalities in 22/26 (84.6%). These included @entity6 , 58% (15/26); low urine volume, 35% (9/26); hyperuricosuria, 27% (7/26); hypocitraturia, 19% (5/26); elevated urine @entity3 , 15% (4/26); and @entity7 , 12% (3/26). CONCLUSION: Many @entity0 with @entity8 have no evidence of @entity4 . Among those who do, recurrence is common, and metabolic profile and composition are varied as in the general stone-forming population.

title: XXXX in @entity8 : evaluation of clinical and metabolic features.

answer: @entity4


abstract: BACKGROUND: Prognostic predictions in @entity8 ( @entity8 ) are usually based on relapse and @entity1 . Thus, assessment of factors associated with @entity1 and clinical outcomes in @entity0 with @entity8 are of significant important. The purpose of this study was to investigate the correlated factors for @entity1 and prognosis for @entity0 with @entity8 . METHODS: We analyzed 159 @entity8 @entity0 who underwent curative surgery at the First Teaching Hospital of Xinjiang Medical University from February 2003 to December 2013 by @entity5 and @entity6 (HE) staining. Immunohistochemistry (IHC) staining for @entity7 was performed in 159 @entity8 and adjacent normal liver specimens. The clinicopathological parameters were analyzed for @entity1 and prognosis, including gender, age, size, @entity3 , @entity2 , foreign body @entity4 and @entity7 protein level. RESULTS: The rate of @entity1 was 22.1%. Chi-square test showed that low levels of @entity7 was associated with @entity1 (P = 0.004). However, multivariate analysis suggested that @entity7 expression is not independent prognostic indicators for overall survival (P = 0.356). In addition, no correlations between prognosis and gender, age, size, @entity3 , @entity2 , foreign body granulomatous, @entity1 were identified. CONCLUSIONS: The finding that a low level of @entity7 is associated with @entity1 in @entity8 @entity0 . At present, it thus remains question whether @entity7 expression is a valid prognostic marker for @entity8 , further investigations are required.

title: Metastatic and prognostic factors in XXXX with @entity8 .

answer: @entity0


abstract: BACKGROUND: Access to "safe" water and "adequate" sanitation are emphasized as important measures for @entity2 control. Indeed, the schistosomes' lifecycles suggest that their transmission may be reduced through safe water and adequate sanitation. However, the evidence has not previously been compiled in a systematic review. METHODOLOGY: We carried out a systematic review and meta-analysis of studies reporting schistosome infection rates in @entity0 who do or do not have access to safe water and adequate sanitation. PubMed, Web of Science, Embase, and the Cochrane Library were searched from inception to 31 December 2013, without restrictions on year of publication or language. Studies' titles and abstracts were screened by two independent assessors. Papers deemed of interest were read in full and appropriate studies included in the meta-analysis. Publication bias was assessed through the visual inspection of funnel plots and through Egger's test. Heterogeneity of datasets within the meta-analysis was quantified using Higgins' I2. PRINCIPAL FINDINGS: Safe water supplies were associated with significantly lower odds of @entity2 (odds ratio (OR)=0.53, 95% confidence interval (CI): 0.47-0.61). Adequate sanitation was associated with lower odds of @entity1 , (OR=0.59, 95% CI: 0.47-0.73) and @entity3 (OR=0.69, 95% CI: 0.57-0.84). Included studies were mainly cross-sectional and quality was largely poor. CONCLUSIONS/SIGNIFICANCE: Our systematic review and meta-analysis suggests that increasing access to safe water and adequate sanitation are important measures to reduce the odds of schistosome infection. However, most of the studies were observational and quality was poor. Hence, there is a pressing need for adequately powered cluster randomized trials comparing schistosome infection risk with access to safe water and adequate sanitation, more studies which rigorously define water and sanitation, and new research on the relationships between water, sanitation, hygiene, @entity0 behavior, and schistosome transmission.

title: The Relationship between Water, Sanitation and XXXX : A Systematic Review and Meta-analysis.

answer: @entity2


abstract: OBJECTIVE: To evaluate longitudinal @entity0 -oriented outcomes in @entity5 over a 14-year time period including time before and after diagnosis. METHODS: The 1996-2007 @entity4 ( @entity4 )-Medicare Claims linked database identified incident @entity5 cases (ICD-9 codes) in @entity0 >= 65 years. Using detailed demographic information from the @entity4 and Medicare claims, a propensity score method identified a matched control group without @entity2 . @entity0 -oriented outcomes, with an emphasis on self-reported falls, @entity3 , and self-rated health ( @entity4 interview), were determined before and after @entity2 diagnosis. Generalized estimating equations were used to assess differences in longitudinal outcomes between cases and controls. RESULTS: We identified 953 @entity5 cases and 953 propensity-matched controls. The mean (SD) age was 77.4 (6.7) years for cases, 76.9 (6.6) years for controls, and 42.1% had @entity1 . Differences were detected in falls 3.0 years before @entity2 diagnosis (case vs control; 32% vs 25%, p = 0.008), 5.0 years for @entity3 (36% vs 27%, p = 0.002), and 5.0 years for good to excellent self-rated health (61% vs 74%, p < 0.0001). Over time, the proportion of fallers increased more rapidly in @entity2 cases compared to controls (p = 0.002), but no differences in @entity3 (p = 0.08) or self-rated health (p = 0.9) were observed. CONCLUSIONS: In older @entity0 , differences in falls, @entity3 , and self-rated health can be detected 3-5 years prior to @entity5 diagnosis, but only falls deteriorates more rapidly over time in @entity2 cases compared to controls. Interventions to improve early @entity5 detection are needed, and future clinical trials should incorporate falls as a key @entity0 -oriented outcome.

title: Longitudinal XXXX -oriented outcomes in @entity2 : Importance of early detection and falls.

answer: @entity0


abstract: Excess @entity3 is frequent after childhood @entity2 treated without BMT. We measured the whole-body percent fat by dual-energy X-ray absorptiometry and the body-mass index (weight/height(2) (kg/m(2)), BMI) in 25 survivors of childhood @entity4 or @entity1 (21 with @entity2 ) who had received TBI and allogeneic BMT a median of 8 years ago (range 4-13). Adjusted for sex and age, the mean BMI was slightly but significantly reduced (0.4 s.d. below predicted) and the whole-body percent fat was significantly increased compared with healthy controls (1.1 s.d. above predicted). Eleven of 25 @entity0 had a percent fat above the 90 percentile of the reference values, which indicates excess @entity3 . Adjusted for sex and age, a higher percent fat was related to additional cranial irradiation. Controlled for this, the whole-body percent fat seemed to be unrelated to age at BMT, length of follow-up, and previous chemotherapy. Compared with untransplanted @entity2 survivors treated with cranial irradiation, BMT survivors had significantly reduced BMI but similar whole body percent fat. BMI was a poor measure of body @entity3 in these @entity0 . In conclusion, survivors of BMT for childhood @entity4 or @entity1 are adipose and slightly underweight and consequently have a substantially reduced lean body mass.

title: Degree of @entity3 after allogeneic BMT for childhood XXXX or @entity1 .

answer: @entity4


abstract: UNASSIGNED: Previous studies reported inconsistent findings about the relationship between pretreatment @entity2 and survival in @entity0 with @entity1 . This study aimed to evaluate the prognostic significance of @entity2 in @entity1 . We searched databases to identify relevant articles. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Fourteen studies including 3,394 @entity0 were eligible for the meta-analysis. Overall, an @entity3 was significantly associated with inferior overall survival (OS, hazard ratio [HR]: 1.66, 95% confidence interval [CI]: 1.42-1.95, P < 0.001) and recurrence-free survival (RFS, HR: 1.67, 95% CI: 1.15-2.42, P = 0.007) but not progression-free survival (PFS, HR: 1.21, 95% CI: 0.89-1.64; P = 0.235). The results were similar for low stage @entity0 treated with surgery alone. Moreover, a pretreatment @entity2 status was significantly associated with higher clinical stage (odd ratio [OR]: 2.39, 95% CI: 1.68-3.38, P < 0.001), positive pelvic node status (OR: 1.58, 95% CI: 1.01- 2.45, P = 0.044) and larger @entity1 size (OR: 2.32, 95% CI: 1.39-3.87, P = 0.001). Pretreatment @entity2 is an independent prognosis predictor in @entity1 @entity0 . It may be used as a readily available biomarker to refine clinical outcome prediction for @entity1 @entity0 .

title: The association of pretreatment @entity2 with prognosis and clinicopathological significance in XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: UNASSIGNED: Weissella spp. are non-spore forming, catalase-negative, gram-positive coccobacilli. They are often misidentified by traditional and commercial phenotypic identification methods as Lactobacillus spp. or Lactobacillus-like organisms. Weissella spp. were previously grouped along with Lactobacillus spp., Leuconostoc spp., and Pediococcus spp. Utilization of more sensitive methods like DNA sequencing or Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) has facilitated identification of Weissella as a unique genus. Nineteen species have been identified to date. W. confusa, @entity5 , and W. viridescens are the only species isolated from @entity0 . The true prevalence of Weissella spp. continues to be probably underestimated. Weissella spp. strains have been isolated from a wide range of habitats including raw milk, feces, fermented cereals, and vegetables. Weisella is believed to be a rare cause of usually nonfatal infections in @entity0 , and is often considered a contaminant. However, in recent years, Weissella spp. have been implicated in @entity4 , @entity1 , and @entity2 . Alterations of the gut flora from surgery or chemotherapy are believed to facilitate translocation of Weissella spp. due to disruption of the mucosal barrier, predisposing the host to infection with this organism. Implications of the isolation of Weissella spp. from blood must be interpreted in context of underlying risk factors. Weissella spp. are inherently resistant to @entity3 . Therefore, early consideraton of the pathogenic role of this bacteria and choice of alternate therapy is important to assure better outcomes.

title: Identification and significance of XXXX .

answer: @entity1


abstract: BACKGROUND: Mucopolysaccharidoses (MPS) are @entity0 caused by deficiency of required glycosaminoglycans breakdown enzymes, inducing @entity2 . Little is known about myocardial deformation involvement in MPS. Our aim was to assess biventricular structure and function in asymptomatic children with MPS using standard echo Doppler and 2D speckle tracking (STE). METHODS: Fifteen MPS children (one type I, six type II, three type III A, one III B, three IV A, one VI), asymptomatic for cardiac symptoms, and 15 age and sex-matched healthy controls underwent echo Doppler and STE. Left ventricular (LV) wall thicknesses, diameters, and mass were normalized by z-score. @entity3 (GLS), global circumferential strain (GCS), global radial strain (GRS) at papillary muscles, LV twisting, and right ventricular (RV) GLS were measured. RESULTS: The two groups were comparable for body mass index, heart rate, and blood pressure. LV mass index and relative wall thickness were higher in MPS. Ejection fraction (EF), and s' velocity did not differ between the two groups. E/A ratio was lower and E/e' higher in MPS. Tricuspid annular plane systolic excursion, RV s' and e' were lower in MPS. LV GLS did not differ between the two groups, but GCS (P=.014), GRS (P=.023), twisting (P=.012), and RV GLS (P<.001) were lower in the MPS group. CONCLUSIONS: @entity3 are detectable in MPS pediatric patients, independently of MPS type, when EF is still normal. RV GLS is also involved consensually with TAPSE reduction. STE can be useful for detection of subclinical @entity1 in MPS.

title: XXXX in pediatric patients with mucopolysaccharidoses: A two-dimensional speckle tracking echocardiography study.

answer: @entity1


abstract: We report a reliable @entity1 model in @entity2 using sequential ligation of the homonymous artery and its diagonal branch. After a left anterior thoracotomy in Corridale @entity2 , the homonymous artery was ligated at a point approximately 40% of the distance from the apex to the base of the heart, and after 1 hour, the diagonal vessel was ligated at a point at the same level. Hemodynamic measurements were done preligation, 30 minutes after the homonymous artery ligation, and 1 hour after diagonal branch ligation. The electrocardiograms were obtained as needed, and cardiac function was also evaluated with ultrasonography. After a predetermined interval (2 months for five animals and 3 months for two animals), the animals were reevaluated in the same way as before, and were killed for postmortem examination of their hearts. All seven animals survived the experimental procedures. Statistically significant @entity0 and increases in pulmonary artery capillary wedge pressure were observed 1 hour after sequential ligation of the homonymous artery and its diagonal branch. Untrasonographic analyses demonstrated variable degrees of anteroseptal @entity3 and @entity3 in all animals. The data from animals at 2 months after coronary artery ligation showed significant increases in central venous pressure, pulmonary artery pressure, and pulmonary artery capillary wedge pressure. Left ventricular enddiastolic dimension and left ventricular end-systolic dimension on ultrasonographic studies were also increased. Electrocardiography showed severe ST elevation immediately after the ligation and pathologic Q waves were found at 2 months after ligation. The thin walled infarcted areas with chamber enlargement were clearly seen in the hearts removed at 2 and 3 months after ligation. In conclusion, we could achieve a reliable ovine model of @entity1 using a simple concept of sequential ligation of the homonymous and diagonal arteries. This animal model was comparable to the clinical situation.

title: XXXX model with sequential ligation of the homonymous artery and its diagonal branch in the @entity2 .

answer: @entity1


abstract: BACKGROUND: Recurrent @entity4 @entity2 is a challenge for maxillofacial surgeons. In severe cases, microvascular tissue transfer is necessary to treat these @entity0 successfully. METHODS: A 23-year-old @entity0 with @entity5 , previously treated elsewhere, presented with a 2-cm defect in the @entity4 . A tongue flap had already been performed. It was decided to close the persistent @entity2 with a lateral upper-arm flap. In a first-step operation, a free graft of buccal @entity6 was fixed to the lateral upper arm subcutaneously and covered with an alloplastic sheet. After 11 weeks, the prelaminated flap was harvested and transferred to the palate. RESULTS: Integration of the buccal @entity6 to the upper arm was uneventful. On harvesting the flap, we found a smooth, thin, and @entity3 with a @entity6 surface of 4 x 4 cm. Healing of the microvascular flap in its recipient site was regular. The @entity2 was closed successfully. CONCLUSIONS: To the authors' knowledge, this is the first report of a lateral upper-arm flap prelaminated with autologous @entity6 . By prelamination, it is possible to circumvent the disadvantage of extraoral skin within the oral cavity and to cover @entity1 with @entity6 , especially in elective procedures, such as cleft cases.

title: XXXX @entity2 closure with a mucosal prelaminated lateral upper arm flap.

answer: @entity4


abstract: BACKGROUND: Increased permeability and uptake of proinflammatory bacterial endotoxins from gut microbiota has been suggested as a mechanism for @entity1 that causes @entity1 -associated insulin resistance. We hypothesized that intestinal barrier function may be restored after Roux-en-Y gastric bypass (RYGB) surgery and thereby contribute to decreased @entity2 . The objective of this study was to investigate levels of the permeability-regulating tight-junction proteins in @entity0 small intestinal mucosa before and after RYGB surgery. METHODS: Paired intraindividual jejunal mucosa samples were retrieved at the time of surgery and 6 to 8 months after surgery. Mucosal cell surface area was calculated by histomorphometry. Mucosal samples were analyzed by proteomics to find patterns of protein regulations. Based on these findings further analyses were performed by Western blotting. Ussing chambers were used to analyze permeability in the retrieved mucosal samples. RESULTS: Mucosal surface area was significantly decreased after surgery. Global protein expression analysis showed a significant increase in the @entity4 ( @entity4 ), which was confirmed by Western blotting. Further analyses showed a significant increase in @entity7 expression after surgery, whereas @entity5 and zonula occludens-1 levels were decreased. Expressions of @entity3 and vinculin were unchanged. Ussing chamber experiments revealed a linear correlation between the epithelial electrical resistance and @entity6 protein expression. CONCLUSION: Several alterations were found in the rerouted small intestine after surgery, indicating a decreased jejunal mucosal surface area and decreased paracellular permeability. These changes could contribute to decreased uptake of luminal microbiota-derived inflammatory mediators such as endotoxins after RYGB.

title: Expression of tight-junction proteins in XXXX proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.

answer: @entity0


abstract: The scarcity of sizeable specimens of normal oral mucosa for experimental purposes has hampered research on oral epithelium. Because large specimens of viable @entity0 vaginal mucosa are readily available and because @entity1 are microscopically similar, vaginal mucosa has been used successfully to establish a @entity0 cyst model in experimental animals. The ultrastructure and distribution of keratin filaments in these epithelia are also similar, as is their permeability to water and a number of chemical substances. Therefore, if vaginal mucosa could be substituted for @entity5 it would expedite research on the epithelium of @entity5 . To strengthen further the concept that vaginal epithelium could replace buccal epithelium in certain experimental studies, the thickness of these epithelia, their patterns of surface keratinization, the presence or absence of intercellular lipid lamellae and their lipid contents were now compared. Thirty-three specimens of vaginal mucosa from postmenopausal @entity0 and 36 of @entity5 were investigated. To compare the thickness of the epithelial layers the number of cell layers in sections of 20 vaginal and 20 buccal mucosal specimens were counted in the three thickest and three thinnest regions of each specimen. Surface keratinization was evaluated on sections stained with the Picro-Mallory method. To demonstrate lipid lamellae two vaginal and two @entity5 specimens were examined electron microscopically after normal fixation and postfixation in @entity7 . Following solvent extraction of 11 vaginal and 14 @entity5 , quantitative lipid analyses were performed using thin-layer chromatography. No statistically significant differences were found between the maximum and minimum number of epithelial cell layers. The patterns of surface keratinization and the distribution and appearance of the lipid lamellae in the intercellular spaces were similar. The lipid composition of the two epithelia corresponded, except for the @entity3 and @entity6 , which were higher in buccal epithelium. @entity4 for vaginal epithelium and @entity2 for buccal epithelium were not determined. Based on structural similarities, a similar lipid composition and earlier findings, it is concluded that vaginal epithelium can be used as a substitute for buccal epithelium in certain in vitro, and possibly for in vivo, studies.

title: A comparative light-microscopic, electron-microscopic and chemical study of XXXX vaginal and buccal epithelium.

answer: @entity0


abstract: All cases of neonatal @entity4 occurring at Neonatal Department of Pediatric Clinic, Catholic University of Rome, from January 1976 to December 1983 were examined retrospectively. Twenty-seven (30%) newborn @entity0 with positive blood cultures for coagulase-negative staphylococcus were identified. Seven (25.9%) of the 27 @entity0 were born at term, 4 AGA and 3 SGA; mean birth weight was 2,804 gm (range 2,280-3,670). All of these neonates had clinical evidence and laboratory signs of @entity1 , and one had the cerebrospinal-fluid culture positive for coagulase-negative staphylococcus. In the remaining 20 @entity0 (74.1%) the mean birth weight was 1,445 gm (range 810 - 2,400) and mean gestational age was 32 weeks (range 27 - 36). In 15 of the 20 preterm @entity0 clinical signs of @entity1 were associated with positive blood culture, and sixty percent of these had received an umbilical artery catheter. An half of coagulase-negative staphylococci isolated from our neonatal @entity1 were DNAse-positive and/or phosphatase-positive and/or @entity5 -positive. Two full-term @entity0 , one with Down syndrome and one with @entity2 , died at 9 days and at 2 weeks of age, respectively. Three of 15 preterm @entity0 with coagulas-negative @entity1 died; deaths were among @entity0 of very low birth weights and immature gestations who had severe @entity3 . These data show that coagulase-negative staphylococcus can be important cause of @entity1 in @entity0 with compromised host defenses as newborn @entity0 , and especially in the premature babies receiving invasive procedures.

title: [ XXXX caused by coagulase-negative staphylococci].

answer: @entity1


abstract: INTRODUCTION: @entity0 with @entity2 ( @entity2 ) have an increased cardiovascular (CV) morbidity and mortality. Pulse-wave velocity ( @entity1 ) and augmentation index (AIx) are non-invasive methods to assess arterial @entity4 , a marker of CV risk. We performed a meta-analysis evaluating the impact of @entity2 on aortic- @entity1 , brachial- @entity1 , brachial-ankle (ba-) @entity1 , AIx, and AIx normalized to a 75 beats/minute heart rate (AIx@75). MATERIALS AND METHODS: Studies evaluating the relationship between @entity2 and aortic- @entity1 , brachial- @entity1 , ba- @entity1 , AIx, and AIx@75 were systematically searched. A total of 25 studies (1,472 @entity2 @entity0 , 1,583 controls) were included. RESULTS: Compared to controls, @entity2 @entity0 showed a significantly higher aortic- @entity1 (mean difference 1.32 m/s; 95% CI 0.77, 1.88; P < 0.00001), ba- @entity1 ( @entity3 198.42 cm/s; 95% CI 45.79, 342.76; P = 0.01), AIx ( @entity3 11.50%; 95% CI 5.15, 17.86; P = 0.0004), and AIx@75 ( @entity3 6.99%; 95% CI 4.92, 9.06; P < 0.00001), with a trend toward a higher brachial- @entity1 ( @entity3 0.34 m/s; 95% CI -0.03, 0.70; P = 0.07). When analyzing studies on early @entity2 , the difference in aortic- @entity1 among @entity2 @entity0 and controls was even higher ( @entity3 2.30 m/s; 95% CI 1.15, 3.45; P < 0.0001). CONCLUSION: Meta-regression showed that a more severe inflammatory status impacted on aortic- @entity1 , AIx, and AIx@75. Arterial @entity4 , a recognized marker of CV risk, is increased in @entity2 @entity0 . This alteration is associated with the severity of the inflammatory status and is present even in early-stage disease.

title: Non-invasive assessment of arterial @entity4 in @entity0 with XXXX : A systematic review and meta-analysis of literature studies.

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) is the most common form of @entity2 in @entity0 with Down Syndrome (DS). @entity3 is a chemical found in the brain that has an important role in memory, attention, reason and language. @entity4 is a "pseudo-irreversible" inhibitor of acetylcholinesterase, which is thought to maintain levels of @entity3 . @entity4 can improve cognitive function and slow the decline of @entity1 in the general population over time. It is important to note that @entity0 with DS tend to present with @entity1 at a much younger age than the normal population as well as having subtle differences in physiology (e.g. metabolism and heart rate) and may therefore have different requirements from the general population. OBJECTIVES: To determine the effectiveness and safety of @entity4 for @entity0 with DS who develop @entity1 . SEARCH STRATEGY: CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, BIOSIS, SCI, SSCI and the NRR were searched up to October 2008. We contacted the manufacturers of @entity4 as well as experts in the field, to ask about reports of unpublished or ongoing trials. SELECTION CRITERIA: Randomised controlled trials of @entity0 with DS and @entity1 in which treatment with @entity4 was administered compared with a placebo group. DATA COLLECTION AND ANALYSIS: No study was identified which met inclusion criteria for this review. MAIN RESULTS: No study was identified which met inclusion criteria for this review. AUTHORS' CONCLUSIONS: As there are no included trials, recommendations cannot be made about @entity4 for @entity1 in DS. Well-designed, adequately powered studies are required.

title: @entity4 for @entity2 in XXXX with Down syndrome.

answer: @entity0


abstract: UNASSIGNED: Background   Anticoagulant treatment is recently being replaced by more aggressive endovascular modalities in the management of acute @entity3 ( @entity3 ). These techniques have been promoted to improve thrombus removal, prolong venous patency, prevent @entity4 , and reduce post @entity1 . The aim of the present study is to overview the short-term results of percutaneous mechanical thrombectomy (PMT) for acute @entity3 . Methods   This retrospective study is based on data from 21 acute @entity3 @entity0 treated with PMT in the cardiovascular surgery department of a tertiary care center. The average age of @entity0 was 48.76 (range: 27-69). Retrievable inferior vena cava (IVC) filters were administered via right subclavian vein or contralateral femoral vein and withdrawn after PMT procedure. Low-molecular-weight heparin (LMWH) was used for anticoagulation in the first 10 days postoperatively. Results   Venous patency was restored in 20/21 @entity0 (95%) at first month, and in 18/21 @entity0 (85%) at sixth month. Valvular competency was preserved in 16 @entity0 (76%). Balloon angioplasty with or without stent implantation was performed in three @entity0 with @entity2 in femoral or iliac veins. Conclusion   In conclusion, PMT is a safe and effective treatment modality that can be used alone in the treatment of acute @entity3 of lower extremities in selected cases. Further controlled trials on larger series and reports on long-term results are warranted to document the actual therapeutic potential and safety this endovascular procedure.

title: Our Short-Term Results with Percutaneous Mechanical Thrombectomy for Treatment of Acute XXXX .

answer: @entity3


abstract: BACKGROUND: Hyperopic shift and chorioretinal folds are common findings with intraorbital masses compressing the posterior pole of the globe. These signs usually regress after @entity1 excision. To the best of our knowledge this is the first reported case, where optical coherence tomography was used to document persistent chorioretinal folds after complete excision of a retrobulbar mass. CASE PRESENTATION: A 47-year-old Caucasian @entity0 was referred to our department with long-documented hyperopic shift and gradually decreasing vision in her left eye. Optical coherence tomography showed chorioretinal folds. Magnetic resonance imaging revealed a retrobulbar mass which caused flattening of the posterior pole of the globe. The @entity1 was successfully removed, and was confirmed to be a cavernous haemangioma on histological assessment. 3  years after surgery the @entity0 still has a similar amount of @entity3 and chorioretinal folds. CONCLUSION: @entity2 and hyperopic shift may persist after @entity1 removal. Long term follow-up is advised to rule out recurrence of the intraorbital mass.

title: Long term follow-up of persistent XXXX and hyperopic shift after complete removal of a retrobulbar mass.

answer: @entity2


abstract: BACKGROUND: Although monitoring foot skin temperatures has been associated with @entity1 foot @entity2 recurrence, no studies have been carried out to test the feasibility among European Caucasians. Moreover, the educational and/or motivational models that promote cognitive or psychosocial processes in these studies are lacking. Thus, we conducted a pilot randomized controlled trial to test the feasibility of monitoring foot skin temperatures in combination with theory-based counselling to standard foot care to reduce @entity1 foot @entity2 recurrence. METHODS: In a single-blinded nurse-led 1-year controlled trial, conducted at a hospital setting in Norway, 41 @entity0 with @entity3 and previous foot @entity2 were randomized to the intervention (n   =   21) or control groups (n   =   20). All @entity0 were instructed in foot care and recording observations daily. Additionally, the intervention group was taught how to monitor and record skin temperature at baseline, and received counselling every third month supporting them to use the new treatment. Subjects observing temperature differences >2.0    C between corresponding sites on the left and right foot on two consecutive days were asked to contact the study nurse and reduce physical activity. Fisher exact test was used to evaluate the effect of the intervention on the proportion of subjects with a foot @entity2 . Kaplan-Meier survival analysis was performed to compare the two groups in regard to the time to development of a foot @entity2 . RESULTS: In the intervention group, 67  % (n   =   14/21) monitored and recorded skin temperatures >= 80  % of the time while 70  % (n   =   14/20) of the controls recorded foot inspections. Foot @entity2 incidence was 39  % (7/21) vs. 50  % (10/20) in the intervention and control groups, respectively (ns). CONCLUSIONS: This feasibility study showed that the addition of counselling to promote self-monitoring of skin temperature to standard care to prevent recurrence of foot @entity2 is feasible in @entity0 with @entity1 in Norway. Home skin temperature monitoring was performed as frequently by the intervention group as usual foot observations in the controls despite the extra effort required. We did not detect a difference in foot @entity2 recurrence between groups, but our study may inform future full scale studies. TRIAL REGISTRATION: Clinicaltrials.gov NCT01269502.

title: A pilot study testing the feasibility of skin temperature monitoring to reduce recurrent foot ulcers in XXXX with @entity1 - a randomized controlled trial.

answer: @entity0


abstract: OBJECTIVES: We reviewed the mechanisms of @entity2 actions and the established and experimental uses of antiandrogens in @entity0 . METHODS: Relevant studies were identified through a computerized bibliographic search (MEDLINE) and through manual review of bibliographies in relevant publications. RESULTS: @entity7 exert major effects on the functions of gonads, sex organs, and various "nonreproductive" organs and systems, including muscles, liver, skin, nervous system, and the immune system. Most, but not all, of the actions of @entity7 may be explained by their binding with specific @entity2 receptors. Antiandrogens prevent @entity7 from expressing their activity at target cells. They act primarily by binding to @entity2 receptors and thus preventing activation of receptors by @entity7 . Steroidal antiandrogens may also exert a wide range of other hormonal and antihormonal effects by interacting with receptors for @entity3 , glucocorticoids, and mineralocorticoids. Furthermore, some antiandrogens may decrease the production of @entity7 by acting at the hypothalamic-pituitary unit and modifying the release of LH, or by directly inhibiting individual enzymes involved in steroidogenesis. Antiandrogens are widely used in the treatment of @entity0 with @entity5 , including @entity6 , idiopathic @entity4 , acne, @entity8 , and hair loss. CONCLUSIONS: Antiandrogens provide a logical and clinically effective pharmacotherapy of @entity1 . However, both steroidal and nonsteroidal antiandrogens may cause significant side effects, largely because of their interactions not only with @entity2 receptors, but also with other receptors and various enzymatic activities. Difficulties in designing the optimal antiandrogen largely result from the complexities of @entity2 metabolism and action in various tissues.

title: XXXX and therapeutic aspects of antiandrogens in @entity0 .

answer: @entity7


abstract: BACKGROUND _ AIMS: Severe @entity1 ( @entity1 ) is a life-threatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether the combination of @entity2 and intensive enteral nutrition therapy is more effective than @entity2 therapy alone in @entity0 with severe @entity1 . METHODS: We enrolled 136 heavy consumers of @entity3 (age, 18-75 y) with recent onset of @entity5 and biopsy-proven severe @entity1 in our study, performed at 18 hospitals in Belgium and 2 in France, from February 2010 through February 2013. Subjects were assigned randomly (1:1) to groups that received either intensive enteral nutrition plus @entity6 or conventional nutrition plus @entity6 (controls). In the intensive enteral nutrition group, enteral nutrition was given via feeding tube for 14 days. The primary end point was @entity0 survival for 6 months. RESULTS: In an intention-to-treat analysis, we found no significant difference between groups in 6-month cumulative mortality: 44.4% of @entity0 died in the intensive enteral nutrition group (95% confidence interval [CI], 32.2%-55.9%) and 52.1% of controls died (95% CI, 39.4%-63.4%) (P  = .406). The enteral feeding tube was withdrawn prematurely from 48.5% of @entity0 , and serious adverse events considered to be related to enteral nutrition occurred in 5 @entity0 . Regardless of group, a greater proportion of @entity0 with a daily calorie intake less than 21.5 kcal/kg/day died (65.8%; 95% CI, 48.8-78.4) than @entity0 with a higher intake of calories (33.1%; 95% CI, 23.1%-43.4%) (P < .001). CONCLUSIONS: In a randomized trial of @entity0 with severe @entity1 treated with @entity4 , we found that intensive enteral nutrition was difficult to implement and did not increase survival. However, low daily energy intake was associated with greater mortality, so adequate nutritional intake should be a main goal for treatment. ClinicalTrials.gov number: NCT01801332.

title: Intensive Enteral Nutrition Is Ineffective for Individuals With Severe XXXX Treated With Corticosteroids.

answer: @entity1


abstract: Free-ranging @entity5 ( @entity5 latirostris) consume a variety of sea grasses and algae. This study compared the @entity0 ( @entity0 ) content, proximate nutrients ( @entity1 [ @entity1 ], @entity3 -extracted crude fat [EE], nonfiber @entity2 [NFC], and ash), and the calculated digestible energy (DE) of sea grasses (Thalassia testudinum, Halodule wrightii, and Syringodium filiforme) collected in spring, summer, and winter, and an alga (Chara sp.) with those of romaine lettuce ( @entity4 . longifolia). Neutral-detergent fiber (NDF), acid-detergent fiber (ADF), and lignin (L) measured after ash-extraction were also compared. Results of statistical tests (C = 0.01) revealed @entity0 content was higher in aquatic vegetation than in lettuce (P = 0.0001), but NDF and ADF were up to threefold greater, EE (P = 0.00001) and @entity1 (P = 0.00001) were 2-9 times less, and NFC (P = 0.0001) was 2-6 times lower in sea grass than in lettuce, on a @entity0 basis. Chara was lower in NDF, ADF, L, EE, @entity1 , and NFC relative to lettuce on a @entity0 basis. Ash content ( @entity0 basis) was higher (P = 0.0001), and DE was 2-6 times lower in aquatic vegetation than in lettuce. Sea grass rhizomes had lower L and higher ash contents ( @entity0 basis) than sea grass leaves. Based on the nutrient analyses, romaine lettuce and sea grasses are not equivalent forages, which suggests that the current diet of captive @entity5 should be reassessed.

title: Proximate nutrient analyses of four species of submerged aquatic vegetation consumed by @entity5 ( @entity5 latirostris) compared to romaine lettuce ( XXXX var. longifolia).

answer: @entity4


abstract: @entity2 ( @entity4 ) of the stomach is rare. Its pathogenesis is also unclear and there are conflicting reports about it in the past. Only about 100 cases have been reported so far in the literature. The current study discusses a new case of @entity3 , from a 50-year-old Chinese male @entity0 diagnosed via subtotal gastrectomy with Roux-en-Y reconstruction and D2 lymphadenectomy. In the stomach, an ulcerated mass in the antrum, measuring 12*8*6 cm, was observed. Further, pathological examination of the resected specimen revealed a well-differentiated @entity4 . Observations indicated @entity1 cell invasion into the serosa, and encroachment into perigastric regional lymph node. A follow-up abdominal CT scan three months later revealed @entity1 invasion into the ascending colon. We assume that this invaded mass was transferred from the @entity3 . Interestingly, the @entity0 is still alive.

title: XXXX : a case report and literature review.

answer: @entity2


abstract: A 69-year-old @entity0 presented with a 6-week history of shortness of breath on exertion, unintentional weight loss, altered bowel habits and lethargy. He was diagnosed with @entity2 2   years previously and started on @entity5 and @entity3 . He subsequently reverted to sinus rhythm and his medication was stopped 1   year prior to presentation. He denied history of @entity4 . On examination, he had a small firm goitre of grade I. His skin was warm and sweaty. Thyroid function tests showed him to be @entity6 . He was started on @entity7 20   mg; however, he further became significantly @entity6 . Given the severity of his presentation and lack of any clinical or biochemical improvement, oral @entity1 30   mg once daily was coadministered. His symptoms subsequently resolved and he became euthyroid. The @entity1 was tapered down and stopped while the @entity7 was incrementally reduced to 10   mg daily.

title: XXXX -induced thyrotoxicosis: type 1 or type 2?

answer: @entity5


abstract: Object Traditionally, the treatment of choice for @entity1 with @entity2 to the calvaria or skull base has been conventional radiation therapy. Because @entity1 with systemic @entity3 are also at risk for intracranial @entity2 , the utility of Gamma Knife surgery (GKS) for these @entity1 has been explored to reduce excess radiation exposure to the perilesional brain parenchyma. The purpose of this study was to report the efficacy of GKS for the treatment of calvarial @entity2 and skull base lesions. Methods The authors performed a retrospective chart review of 21 @entity1 with at least 1 calvarial or skull base metastatic lesion treated with GKS during 2001-2013. For 7 @entity4 , a novel technique, in which a bolus was placed over the treatment site, was used. For determination of local control or disease progression, radiation therapy data were examined and posttreatment MR images and oncology records were reviewed. Survival times from the date of procedure were estimated by using Kaplan-Meier analyses. Results The median @entity1 age at treatment was 57 years (range 29-84 years). A total of 19 (90%) @entity1 received treatment for single lesions, 1 @entity1 received treatment for 3 lesions, and 1 @entity1 received treatment for 4 lesions. The most common @entity3 was @entity0 (24% of @entity1 ). Per lesion, the median clinical and radiographic follow-up times were 10.3 months (range 0-71.9 months) and 7.1 months (range 0-61.3 months), respectively. Of the 26 lesions analyzed, 14 (54%) were located in calvarial bones and 12 (46%) were located in the skull base. The median lesion volume was 5.3 cm(3) (range 0.3-55.6 cm(3)), and the median prescription margin dose was 15 Gy (range 13-24 Gy). The median overall survival time for all @entity1 was 35.9 months, and the 1-year local control rate was 88.9% (95% CI 74.4%-100%). Local control rates did not differ between lesions treated with the bolus technique and those treated with traditional methods or between @entity4 and skull base lesions (p > 0.05). Of the 3 @entity1 for whom local treatment failed, 1 @entity1 received no further treatment and 2 @entity1 responded to salvage chemotherapy. Subsequent brain parenchymal @entity2 developed in 2 @entity1 , who then underwent GKS. Conclusions GKS is an effective treatment modality for @entity1 with @entity2 to the calvarial bones or skull base. For @entity1 with superficial @entity4 , a novel approach with bolus application resulted in excellent rates of local control. GKS provides an effective therapeutic alternative to conventional radiation therapy and should be considered for @entity1 at risk for calvarial @entity2 and brain parenchymal @entity2 .

title: Calvarial and skull base XXXX : expanding the clinical utility of Gamma Knife surgery.

answer: @entity2


abstract: Cartilage cells are normally studied under atmospheric pressure conditions and without loading. However, since cartilage exists in a condition of reduced @entity0 and intermittent hydrostatic pressure we hypothesized lower partial @entity0 pressures ( @entity3 ) and different intermittent hydrostatic pressures (IHP) would increase articular chondrocyte proliferation and matrix production and to stabilize chondrocyte phenotype in vitro. Monolayers of adult @entity1 articular chondrocytes were cultured under 5% or 21% @entity3 in combination with IHP (0.2 MPa amplitude, frequencies 5/5s = 0.1 Hz, 30/2 or 2/30 min on/off loading). We measured proliferation (3H- @entity2 incorporation) and collagen secretion (protein-binding assay, collagen type II-ELISA and immunocytochemical staining of pericellular collagen types I, II and IX). Reduced @entity3 stimulated proliferation and collagen type II and IX secretion of chondrocytes in comparison to 21% @entity3 . Additionally, collagen type I expression was delayed by low @entity3 , indicating a stabilization of the cell phenotype. IHP 5/5s and 30/2 min inhibited proliferation but increased collagen secretion (pericellular collagen type IX was decreased). IHP 30/2 min delayed first expression of collagen type I. In contrast, IHP 2/30 min increased proliferation, but lowered collagen expression. All stimulating or inhibiting effects of @entity3 and IHP were additive and vice versa. Reduced @entity3 and different settings of IHP increased proliferation, collagen secretion, and phenotype stability of chondrocytes. The @entity0 - and IHP-induced effects were additive, suggesting that a combination of these parameters might be a useful tool in cartilage tissue engineering.

title: Combination of reduced XXXX tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering.

answer: @entity0


abstract: OBJECTIVES: The objective of this study was to investigate @entity3 -resistant @entity2 isolates harbouring erm(TR), an erm(A) gene subclass, with emphasis on their erm(TR)-carrying genetic elements. Four erm(TR)-carrying elements have been described to date: three closely related (ICE10750-RD.2, Tn1806 and ICESp1108) in @entity1 , @entity0 and @entity1 , respectively; and one completely different (IMESp2907, embedded in ICESp2906 to form ICESp2905) in @entity1 . METHODS: Seventeen @entity3 -resistant erm(TR)-positive @entity2 isolates were phenotypically and genotypically characterized. Their erm(TR)-carrying elements were explored by analysing the distinctive recombination genes of known erm(TR)-carrying integrative and conjugative elements (ICEs) and by PCR mapping. The new genetic context and organization of IMESp2907 in @entity2 were explored using several experimental procedures and in silico analyses. RESULTS: Five isolates harboured ICE10750-RD.2/Tn1806, five isolates harboured ICESp1108 and five isolates bore unknown erm(TR)-carrying elements. The remaining two isolates, exhibiting identical serotypes and pulsotypes, harboured IMESp2907 in a new genetic environment, which was further investigated in one of the two isolates, SagTR7. IMESp2907 was circularizable in @entity2 , as described in @entity1 . The new IMESp2907 junctions were identified based on its site-specific integration; the att sites were almost identical to those in @entity1 . In strain SagTR7, erm(TR)-carrying IMESp2907 was embedded in an erm(TR)-less internal element related to ICE10750-RD.2/Tn1806, which, in turn, was embedded in an ICESde3396-like element. The resulting whole ICE, ICESagTR7 (   129 kb), was integrated into the chromosome downstream of the rplL gene, and was excisable in circular form and transferable by conjugation. CONCLUSIONS: This is the first study exploring erm(TR)-carrying genetic elements in @entity2 .

title: @entity3 resistance gene erm(TR) and erm(TR)-carrying genetic elements in XXXX : characterization of ICESagTR7, a new composite element containing IMESp2907.

answer: @entity2


abstract: UNASSIGNED: We prospectively examined the relation of @entity2 ( @entity2 ), a marker of biological aging, to phobic @entity1 in later-life. @entity2 in peripheral blood leukocytes were measured among 3194 @entity0 in the Nurses' Health Study who provided blood samples in 1989/90. The Crown-Crisp Phobic Index (CCI, range=0-16) was assessed in 1988 and 2004. Only @entity0 with CCI <=3 (consistent with no meaningful @entity1 ) in 1988 were included. We related baseline @entity2 to odds ratios (ORs) of incident high @entity1 (CCI>= 6). To enhance clinical relevance, we used finite mixture modeling (FMM) to relate baseline @entity2 to latent classes of CCI in 2004. @entity2 were not significantly associated with high @entity1 after 16 years of follow-up. However, FMM identified 3 groups of phobic symptoms in later-life: severe, minimal/intermediate, and non-anxious. The severe group had non-significantly shorter multivariable-adjusted mean @entity2 than the minimal/intermediate and non-anxious groups. @entity0 with shorter telomeres vs. longest telomeres had non-significantly higher likelihood of being in the severe vs. non-anxious group. Overall, there was no significant association between @entity2 and incident @entity1 . Further work is required to explore potential connections of telomere length and emergence of severe @entity1 during later-life.

title: A prospective study of leukocyte telomere length and risk of phobic XXXX among @entity0 .

answer: @entity1


abstract: BACKGROUND: Twelve-lead electrocardiography (ECG) is the most important source for the early diagnosis of an acute @entity2 . However, its diagnostic value when the sequence of ventricular activation is altered by ventricular pacing is unknown. The aim of the study was to evaluate the ECG changes on the paced ECG during percutaneous coronary intervention (PCI) by doing temporary pacing. METHODS AND RESULTS: Standard 12 lead baseline and temporary pacing ECG records were taken before the intervention in elective PCI @entity0 . Standard 12 lead and temporary pacing ECG records were repeated during the balloon inflation. Fifteen (12 @entity0 and 3 @entity0 ; age 57.2+/-9.7 years) subjects who were undergoing routine PCI were studied. Mean Delta ST deviation on the normal conduction ECG during inflation was 1.03+/-1.02 mV and mean Delta ST deviation on the paced ECG during inflation was 1.7+/-1.6 mV. The pre-inflation mean QRS duration on the paced ECG was 143.2+/-2.8 ms and during inflation mean QRS duration was 157.8+/-12.5 ms. The mean QRS prolongation was 14.6+/-13.6 ms on the paced ECG. Despite the presence of paced ECG abnormalities, significant ischemic ST segment deviations were seen after referencing the ST segment deviations to the pre-PCI. Also, there is significant QRS prolongation on the paced ECG during @entity1 . CONCLUSIONS: The present study extends the correlation between normal and paced ECG during @entity1 and the QRS prolongation could be a marker of @entity2 on the paced electrocardiogram.

title: Early electrocardiographic diagnosis of acute coronary XXXX on the paced electrocardiogram.

answer: @entity1


abstract: Risk assessments often must consider exposures that vary over time or for which the exposure duration of concern differs from the available data, and a variety of extrapolation procedures have been devised accordingly. The present experiments explore the relationship(s) between exposure concentration (C) and time (t) to investigate procedures for assessing the risks of short-term solvent exposures. The first hypothesis tested was that the product of C x t would produce a constant health effect (Haber's rule). The second hypothesis tested was that exposure conditions produce effects in proportion to the tissue concentrations created. Awake, adult, male Long-Evans (LE) @entity0 were exposed to @entity1 ( @entity2 ) vapor in a head-only exposure chamber while pattern onset/offset visual evoked potentials (VEPs) were recorded. Exposure conditions were designed to provide C x t products of 0 ppm/h (0 ppm for 4 h) or 4000 ppm/h created through four exposure scenarios: 1000 ppm for 4 h; 2000 ppm for 2 h; 3000 ppm for 1.3 h; or 4000 ppm for 1h (n = 9-10/concentration). The amplitude of the VEP frequency double component (F2) was decreased significantly by exposure; this decrease was related to C but not to t or to the C x t product, indicating that Haber's rule did not hold. The mean amplitude (+/- SEM in muV) of the F2 component in the control and treatment groups measured 4.4 +/- 0.5 (0 ppm/4 h), 3.1 +/- 0.5 (1000 ppm/4 h), 3.1 +/- 0.4 (2000 ppm/2 h), 2.3 +/- 0.3 (3000 ppm/1.3 h), and 1.9 +/- 0.4 (4000 ppm/1 h). A physiologically based pharmacokinetic (PBPK) model was used to estimate the concentrations of @entity2 in the brain achieved during each exposure condition. The F2 amplitude of the VEP decreased monotonically as a function of the estimated peak brain concentration but was not related to the area under the curve (AUC) of the brain @entity2 concentration. In comparison to estimates from the PBPK model, extrapolations based on Haber's rule yielded approximately a 6-fold error in estimated exposure duration when extrapolating across only a 4-fold change in exposure concentration. These results indicate that the use of a linear form of Haber's rule will not predict accurately the risks of acute exposure to @entity2 , nor will an estimate of AUC of brain @entity2 . However, an estimate of the brain @entity2 concentration at the time of VEP testing predicted the effects of @entity2 across exposure concentrations and durations.

title: Dose-based duration adjustments for the effects of inhaled @entity1 on XXXX visual function.

answer: @entity0


abstract: OBJECTIVE: Most conceptualizations of @entity5 acknowledge the importance of culture and social circumstances. Cultural and social influences may differ for @entity0 of different racial or ethnic groups, and this circumstance may lead them to experience and adjust differently to @entity2 . The current study compared adjustment to @entity5 by blacks and whites seeking treatment for @entity5 . SUBJECTS AND MEASURES: Fifty-seven black and 207 white @entity0 completed measures of @entity1 , @entity3 , disability, @entity2 , and physical symptoms during their initial visit to a university @entity2 clinic. RESULTS: Comparisons showed that the groups did not differ with regard to age, sex, education, chronicity of @entity2 , @entity2 location, work status, previous surgeries, medical diagnosis, medication, wage replacement, or involvement in litigation. However, the black group reported higher @entity2 severity, more avoidance of activity, more fearful thinking, more physical symptoms, and greater physical and @entity4 . The groups remained significantly different with regard to avoidance, fearful thinking, and physical symptoms after @entity2 severity was statistically controlled for; however, they did not remain different on disability. CONCLUSIONS: These results show that blacks and whites with @entity5 experience @entity2 differently. Several factors may underlie these differences, including family situation, health care experiences, or other unmeasured behavioral, environmental, or social influences. Other investigators should attempt to replicate these findings and more closely examine variables that may explain them.

title: A comparison of blacks and whites seeking treatment for XXXX .

answer: @entity5


abstract: Fluorescence spectroscopy offers an effective, noninvasive approach to the detection of precancers in multiple organ sites. Clinical studies have demonstrated that fluorescence spectroscopy can provide highly sensitive, specific and cost-effective diagnosis of cervical precancers. However, the underlying biochemical mechanisms responsible for differences in the fluorescence spectra of normal and @entity3 tissue are not fully understood. We designed a study to assess the differences in autofluorescence of normal and @entity3 cervical tissue. Transverse, fresh tissue sections were prepared from colposcopically normal and abnormal biopsies in a 34- @entity0 study. Autofluorescence images were acquired at 380 and 460 nm excitation. Results showed statistically significant increases in epithelial fluorescence intensity (arbitrary units) at 380 nm excitation in @entity3 tissue (106 +/- 39) relative to normal tissue (85 +/- 30). The fluorophore responsible for this increase is possibly reduced @entity2 . Stromal fluorescence intensities in the @entity3 samples decreased at both 380 nm (102 +/- 34 [ @entity1 ] vs 151 +/- 44 [normal]) and 460 nm excitation (93 +/- 35 [ @entity1 ] vs 137 +/- 49 [normal]), wavelengths at which collagen is excited. Decreased redox ratio (17-40% reduction) in @entity3 tissue sections, indicative of increased metabolic activity, was observed in one-third of the paired samples. These results provide valuable insight into the biological basis of the differences in fluorescence of normal and precancerous cervical tissue.

title: Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with XXXX .

answer: @entity1