abstract: OBJECTIVE: To evaluate the correlation between @entity2 and @entity1 . STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Eye Department of Postgraduate Medical Institute, Lahore General Hospital, from August 2012 to February 2013. METHODOLOGY: A total of 258 @entity0 suffering from type-2 @entity1 were included. Axial length was measured by two optometrists using contact type ultrasound biometer. Colored retinal photographs, red free retinal photographs and Fundus Fluorescein Angiography (FFA) were performed on all @entity0 using standard fundus camera. All fundus photographs and angiograms were independently reviewed and graded by two qualified vitreoretinal fellows. RESULTS: Out of 258 @entity0 , 163 were males (63.2%) and 95 (36.8%) were females. Average age of @entity0 was 56.30    7.57 years. Average axial length of right and left eyes were 23.16 mm and 23.15 mm respectively. There was statistically significant negative correlation between axial length and severity of @entity1 in the right eye, (Spearman correlation = -0.511, p = 0.0001) as well as the left eye (Spearman correlation = -0.522, p = 0.0001). CONCLUSION: There is a protective influence of longer axial length of globe on the stage and severity of @entity1 . This study may help in modifying the screening protocol for @entity1 amongst @entity0 of differing axial lengths.

title: @entity2 and its influence on XXXX .

answer: @entity1


abstract: OBJECTIVES: To estimate the incidence of surgical complications and associated in-hospital morbidity and mortality following surgery for malignant @entity6 . @entity0 AND METHODS: The Nationwide Inpatient Sample (NIS) database was queried from 2002 to 2011. All adult @entity0 who underwent elective brain surgery for a @entity6 were included. @entity3 included wrong side surgery, retention of a foreign object, @entity2 , @entity5 , @entity4 / @entity7 complicating a procedure, and @entity1 . A regression model was conducted to estimate the odds ratios (OR) with their 95% confidence intervals (95% CI) of in-hospital mortality for each surgical complication. RESULTS: A total of 16,530 admissions were analyzed, with 601 (36.2 events per 1000 cases) surgical complications occurring in 567 @entity0 . Over the examined 10-year period, the overall incidence of surgical complications did not change (P=0.061) except for @entity2 , which increased in incidence from 14.1 to 19.8 events per 1000 between 2002 and 2011 (P=0.023). @entity0 who developed a surgical complication had significantly longer lengths of stay, total hospital costs, and higher rates of other complications. @entity0 who experienced an @entity2 had a significantly increased risk of mortality (OR 9.6; 95% 6.3-14.8) and so were @entity0 with a @entity4 / @entity7 (OR 3.3; 95% CI 1.6-6.6). CONCLUSION: In this study of an administrative database, @entity0 undergoing surgery for a @entity6 who suffered from a surgical complication had significantly longer lengths of stay, total hospital charges, and complication rates. Having a surgical complication was also an independent risk factor for in-hospital mortality. Nonetheless, it is unclear whether all surgical complications were clinically relevant, and further research is encouraged.

title: @entity3 following XXXX surgery: An analysis of 2002-2011 data.

answer: @entity6


abstract: PURPOSE: Although segmentectomy is attempted for small @entity2 ( @entity2 ) @entity1 , no reports have so far described how many of these @entity1 can be candidates for a successful resection by single segmentectomy. METHODS: In all, 135 @entity0 with peripheral p-T1N0M0 @entity2 were examined. The @entity1 were classified into five groups divided by every 0.5-cm increase in size. @entity1 locations were classified into two groups - limited to within one segment and extended beyond one segment - based on the identification of whether pulmonary vessels and the bronchi were involved in the @entity1 on high-resolution computed tomography. Differences in the proportion of @entity1 limited within one segment between @entity1 smaller and larger than each class of @entity1 size were assessed. RESULTS: The @entity1 sizes were 0-1.0 cm in 8 @entity1 , 1.1-1.5 cm in 27, 1.6-2.0 cm in 35, 2.1-2.5 cm in 34, and 2.6-3.0 cm in 31 @entity1 . Of these 135 @entity1 , 92 (65%) were limited to one segment, whereas 48 (35%) had extended beyond one segment. When the @entity1 size was less than 30 mm, the proportion of @entity1 limited within one segment did not show any significant difference depending on the size of the @entity1 . CONCLUSIONS: More than one-third of p-T1N0M0 @entity2 extended beyond one segment, irrespective of size. It is therefore noteworthy that resection of up to two segments or lobectomy should be undertaken for prevention of local recurrence in @entity0 with p-T1N0M0 peripheral @entity2 .

title: How many pathological T1N0M0 XXXX can be completely resected in one segment? Special reference to high-resolution computed tomography findings.

answer: @entity2


abstract: Young, healthy outpatients (100) undergoing restorative dentistry and/or oral surgery under enfluranenitrous @entity8 - @entity1 anaesthesia were given 0.014 mg/kg of @entity7 or a saline placebo i.v. in a double-blind random fashion 5 min after induction of anaesthesia to prevent @entity4 . Overall, less @entity0 given @entity7 were nauseated (18%) or vomited (7%) in comparison with @entity0 given saline (27% and 11%, respectively). During the first postoperative hour, 4% of @entity0 given @entity7 were nauseated and 2% vomited, whereas 16% of @entity0 given saline were nauseated and 6% vomited. Four @entity0 given saline were not discharged from the clinic 1 h after anaesthesia owing to prolonged @entity2 and @entity3 . The time elapsed until the @entity0 were oriented as to time and place after cessation of @entity6 and @entity5 administration was similar in both groups (mean +/- s.d., 13.5 +/- 4.7 min). Thirty minutes after anaesthesia, the ability to walk on a straight line was significantly (P less than 0.001) worse in @entity0 given @entity7 as compared to @entity0 given saline. After 60 min, only one @entity0 given @entity7 and four @entity0 who received saline and vomited took side steps or were unable to walk. Psychomotor performance was significantly (P less than 0.05) better in a perceptual speed test both 30 and 60 min after anaesthesia in @entity0 receiving saline as compared to those given @entity7 . It is concluded that although @entity7 is a less effective antiemetic after outpatient than after inpatient enflurane anaesthesia, small doses of @entity7 may be used for outpatients prone to @entity3 to prevent delayed discharge from the clinic due to prolonged @entity3 .

title: Effect of a small dose of @entity7 on XXXX , @entity3 and recovery after outpatient enflurane anaesthesia.

answer: @entity2


abstract: UNASSIGNED: Colistin and @entity4 are effective treatment options for Gram-negative resistant bacteria but are used as last-line therapy due to their dose-limiting nephrotoxicity. A critical factor in developing safer polymyxin analogues is understanding accumulation of the drugs and their metabolites, which is currently limited due to the lack of effective techniques for analysis of these challenging molecules. @entity1 ( @entity1 ) allows direct detection of targets (drugs, metabolites, and endogenous compounds) from tissue sections. The presented study exemplifies the utility of @entity1 by measuring the distribution of @entity5 , colistin, and @entity4 nonapeptide ( @entity6 ) within dosed @entity0 kidney tissue sections. The label-free @entity1 analysis revealed that the nephrotoxic compounds (polymyxin B1 and @entity3 ) preferentially accumulated in the renal cortical region. The less nephrotoxic analogue, @entity6 , was more uniformly distributed throughout the kidney. In addition, metabolites of the dosed compounds were detected by @entity1 . Kidney homogenates were analyzed using LC/MS/MS to determine total drug exposure and for metabolite identification. To our knowledge, this is the first time such techniques have been utilized to measure the distribution of @entity2 drugs and their metabolites. By simultaneously detecting the distribution of drug and drug metabolites, @entity1 offers a powerful alternative to tissue homogenization analysis and label or antibody-based imaging.

title: Investigating Nephrotoxicity of XXXX Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging.

answer: @entity2


abstract: Complex III (CIII; ubiquinol @entity6 reductase of the mitochondrial respiratory chain) catalyzes electron transfer from @entity5 and @entity4 -linked dehydrogenases to @entity6 . CIII is made up of 11 subunits, of which all but one ( @entity8 ) are encoded by nuclear DNA. @entity7 are rare and manifest heterogeneous clinical presentations. Although pathogenic mutations in the gene encoding mitochondrial @entity8 have been described, mutations in the nuclear-DNA-encoded subunits have not been reported. Involvement of various genes has been indicated in assembly of @entity3 CIII (refs. 8-11). So far only one such gene, @entity9 , has been identified in @entity0 . @entity9 represents, therefore, an obvious candidate gene in @entity7 . Here, we report @entity9 mutations in six @entity0 , from four unrelated families and presenting neonatal proximal @entity1 , hepatic involvement and @entity2 . Complementation study in @entity3 confirmed the deleterious effect of these mutations. Mutation of @entity9 would seem to be a frequent cause of @entity7 , as one-third of our @entity0 have @entity9 mutations.

title: A mutant mitochondrial respiratory chain assembly protein causes @entity7 in @entity0 with @entity1 , XXXX and liver failure.

answer: @entity2


abstract: BACKGROUND: Medication is the mainstay of treatment for @entity2 or @entity2 -like illnesses. Many @entity0 , however, continue to experience symptoms in spite of medication. In addition to medication, creative therapies, such as art therapy may be helpful. Art therapy allows exploration of the @entity0 's inner world in a non-threatening way through a therapeutic relationship and the use of art materials. It was mainly developed in adult @entity1 inpatient units and was designed for use with @entity0 in whom verbal psychotherapy would be impossible. OBJECTIVES: To review the effects of art therapy as an adjunctive treatment for @entity2 compared with standard care and other psychosocial interventions. SEARCH STRATEGY: We searched the Cochrane @entity2 Group's Register (May 2002), hand searched reference lists and 'Inscape' (the Journal of the British Association of Art Therapists), and contacted relevant authors. SELECTION CRITERIA: All randomised controlled trials that compared art therapy with standard care or other psychosocial interventions for @entity2 . DATA COLLECTION AND ANALYSIS: Studies were reliably selected, quality assessed and data extracted. Data were excluded where more than 50% of @entity0 in any group were lost to follow up. For binary outcomes we calculated a fixed effects risk ratio (RR) and its 95% confidence interval (CI). MAIN RESULTS: The search identified 57 reports but only two studies (total n=137) met the inclusion criteria. Both compared art therapy plus standard care with standard care alone. Fewer @entity0 allocated to art therapy left the study before 20 weeks compared with those given standard care alone (n=47, 1 RCT, RR 0.34 CI 0.15 to 0.8, NNT 3 CI 1.5 to 7). Measures of change in mental state, interpersonal relationships and social networking were reported but the data were too problematic to interpret with confidence. Much data was lost due to poor reporting or inappropriate use of scales. REVIEWER'S CONCLUSIONS: Randomised studies have been proven to be possible in this field. The use of art therapy for serious mental illnesses should continue to be under evaluation as its benefits, or harms, are unclear.

title: Art therapy for XXXX or @entity2 -like illnesses.

answer: @entity2


abstract: BACKGROUND/AIMS: To examine the reproducibility of lesion dimensions of the @entity2 ( @entity2 ) in neovascular @entity3 ( @entity3 ) with polarisation-sensitive optical coherence tomography (PS- @entity5 ), specifically imaging the @entity2 . METHODS: Twenty-six @entity0 (28 eyes) with @entity3 were included in this study, and examined by a PS- @entity5 prototype. Each @entity0 was scanned five times at a 1-day visit. The PS- @entity5 B-scan located closest to the macular centre presenting with @entity2 @entity1 was identified, and the longitudinal diameter of the lesion was quantified manually using AutoCAD 2008. This procedure was followed for the identical B-scan position in all five scans per eye and @entity0 . Reproducibility of qualitative changes in PS- @entity5 was evaluated. Interobserver variability was assessed. Results were compared with intensity-based spectral-domain @entity5 (SD- @entity5 ) imaging. RESULTS: Mean variability of all @entity1 lesion dimensions was 0.10   mm (SD  =0.06   mm). Coefficient of variation (SD  /mean) was 0.06 on average (SD  =0.03). Interobserver variability assessment showed a mean difference of 0.02   mm across all @entity0 regarding @entity2 lesion size evaluation (paired t test: p=0.38). Spearman correlation coefficient was r=0.98, p<0.001. Results revealed a good overall reproducibility of    90%. PS- @entity5 specifically detected the @entity2 in all eyes compared with conventional intensity-based SD- @entity5 that was not capable to clearly identify @entity2 @entity1 in 25 eyes (89.3%, p<0.01). CONCLUSIONS: PS- @entity5 offers good reproducibility of @entity2 @entity1 assessment in @entity3 , and may be suitable for precise @entity2 evaluation in clinical practice. PS- @entity5 unambiguously identifies @entity2 changes in @entity4 compared with intensity-based SD- @entity5 that does not identify the @entity2 status reliably.

title: Polarisation-sensitive XXXX is useful for evaluating retinal pigment epithelial lesions in @entity0 with @entity3 .

answer: @entity5


abstract: BACKGROUND: Oxidative stress and @entity8 are important elements in the pathogenesis of inflammatory diseases and @entity1 . Our aim was to evaluate the role of both and of antioxidant capacity in the @entity5 sequence in @entity4 . METHODS: In mucosal specimens from 59 @entity0 grouped as having symptomatic @entity3 , @entity4 , or @entity5 in the esophagus, plus controls, we measured @entity7 activity, superoxidase dismutase activity, @entity6 content, and total aromatic DNA adducts. To evaluate blood vessel densities and angioarchitecture, we used immunohistochemistry and a modified whole-mount technique. Sections were stained with endothelium-specific markers and smooth muscle cell actin. RESULTS: The @entity2 sequence revealed progressively increased oxidative stress (increased @entity7 activity), decreased antioxidant capacity ( @entity6 content), and simultaneous formation of DNA adducts. Pooled data show a negative correlation between @entity6 content and DNA adducts (-0.28; P =.05). This sequence was also characterized by increased intensity in microvessels and an increasing percentage of immature blood vessels. In addition, the whole-mount technique offered 3-dimensional evidence that the rich new vascular bed is highly abnormal, with repeated twists, bends, or turns, even in nonmalignant Barrett esophagus. CONCLUSIONS: Increased oxidative stress, decreased antioxidant capacity, and a negative correlation between @entity6 content and DNA adduct formation indicate a link between oxidative stress and @entity4 . Simultaneously, this transformation acquires angiogenic capacity, strong neovascularization, and abnormal angioarchitecture.

title: Simultaneous progression of oxidative stress and @entity8 in XXXX .

answer: @entity1


abstract: BACKGROUND: Phase-contrast magnetic resonance imaging (PC-MRI) enables quantification of cerebrospinal fluid (CSF) flow and total cerebral blood (tCBF) flow and may be of value for the etiological diagnosis of @entity3 . This investigation aimed to study CSF flow and intracerebral vascular flow in @entity0 with @entity4 ( @entity4 ) and @entity0 with @entity2 ( @entity2 ) and to compare the results with @entity0 with @entity7 ( @entity7 ) and with healthy elderly volunteers ( @entity6 ). METHODS: Ten @entity2 and 9 mild @entity4 @entity0 were identified in a comprehensive neurological and neuropsychological assessment. They underwent brain MRI; PC-MRI pulse sequence was performed with the following parameters: two views per segment; @entity5 angle: 25   for vascular flow and 20   for CSF flow; field-of-view (FOV): 14   14 mm  ; matrix: 256   128; slice thickness: 5 mm; with one excitation for exams on the 3 T machine, and 2 excitations for the 1.5 T machine exams. Velocity (encoding) sensitization was set to 80 cm/s for the vessels at the cervical level, 10 or 20 cm/s for the aqueduct and 5 cm/s for the cervical subarachnoid space (SAS). Dynamic flow images were analyzed with in-house processing software. The @entity0 ' results were compared with those obtained for HEVs (n = 12), and for @entity7 @entity0 (n = 13), using multivariate analysis. RESULTS: Arterial tCBF and the calculated pulsatility index were significantly greater in @entity2 @entity0 than in HEVs. In contrast, vascular parameters were lower in @entity7 @entity0 . Cervical CSF flow analysis yielded similar values for all four populations. Aqueductal CSF @entity1 volumes (in  l per cardiac cycle) were similar in HEVs (34    17) and @entity4 @entity0 (39    18). In contrast, the aqueductal CSF was hyperdynamic in @entity2 @entity0 (73    33) and even more so in @entity7 @entity0 (167    89). CONCLUSION: Our preliminary data show that @entity2 @entity0 present with high systolic arterial peak flows, which are associated with higher mean total cerebral arterial flows. @entity8 are within normal range in @entity4 and higher than normal in @entity7 . This study provides an original dynamic vision of cerebral @entity3 , consistent with the vascular theory for @entity4 , and supporting primary flow disturbances different from those observed in @entity7 .

title: Cerebrospinal fluid and blood flow in mild @entity2 and @entity4 : a differential diagnosis from XXXX .

answer: @entity7


abstract: PURPOSE: The aim of the study was to evaluate the feasibility and efficacy of the combination of @entity15 , @entity16 , @entity14 , and @entity8 (MIFAP) in @entity0 with prognostically unfavorable recurrent and @entity9 ( @entity9 ) and @entity13 ( @entity13 ). METHODS: Forty-six @entity0 (median age 43 years, range 18-63) with relapsed (n = 15) or refractory (n = 31) @entity6 were enrolled ( @entity9 , n = 13; low-grade/transformed @entity13 , n = 4; high-grade @entity13 , n = 29). A total of 39 @entity0 (85%) showed multiply @entity3 with a duration of prior remission of < 12 months (n = 8) or had @entity6 being resistant to prior chemotherapy (n = 31). The MIFAP therapy consisted of @entity16 (15 mg/m2, q. 12 h, day 1-4), @entity14 (50 mg/m2 by continuous infusion (CI) over 22 h, day 1-4), @entity8 (25 or 30 mg/m2 by CI over 24 h, day 1-4), and @entity15 (4 mg/m2, day 2-5). RESULTS: Thirteen @entity0 (28%) achieved complete remission (CR) and 15 @entity0 (33%) partial remission (PR), for an overall response (OR) rate of 61%. Twenty-two @entity0 responding to MIFAP (10 CR, 12 PR) have been consolidated by high-dose therapy (HDT) with hematopoietic @entity1 ( @entity1 ). After a median follow-up of 12 months, 16 @entity0 are in continuous CR (CCR) (n = 14) or CCRu (unconfirmed) (n = 2). The median duration of event-free survival (EFS) and @entity11 ( @entity11 ) were 6.5 and 19.3 months, respectively. Probabilities of EFS and @entity11 after 3 years were 19% and 40%. Responders consolidated by subsequent HDT showed rates for 3-year EFS and @entity11 of 40% and 66%, respectively. Unfavorable prognostic factors for EFS by univariate analysis were @entity6 and the presence of @entity10 . Significant prognostic factors for @entity11 were @entity13 , @entity6 , @entity10 , and bone marrow involvement. The major @entity4 were @entity12 and @entity7 of the World Health Organization (WHO) grade IV in nearly all courses (median duration 10 and 11 days). In contrast, non-hematological side effects were moderate, predominantly of WHO grades I and II. Treatment-related mortality with MIFAP was 4% (two @entity0 with @entity5 by @entity2 ). CONCLUSIONS: MIFAP is an effective salvage protocol for @entity0 with poor-risk recurrent or refractory @entity9 and @entity13 . The observed @entity4 seems to be acceptable considering the unfavorable prognosis and intensive pretreatment. The results in @entity0 responding to MIFAP and afterwards undergoing HDT with autologous stem cell support are even comparable to those published in @entity0 with prognostically more @entity3 .

title: Salvage chemotherapy with @entity15 , @entity16 , XXXX , and @entity8 (MIFAP) in relapsing and @entity6 .

answer: @entity14


abstract: BACKGROUND: Victims of abusive @entity5 have poor outcomes compared to other injured @entity0 . There is often a delay in diagnosis as these young @entity0 are unable to communicate with healthcare providers. These critically injured @entity0 would benefit from early identification and therapy. METHODS: We performed a retrospective review of our single hospital @entity1 registry from 2005-2014. All level 1 pediatric (age 0-17) @entity1 @entity0 who sustained abusive @entity5 were included. Exclusion criteria included: no admission coagulation studies, prehospital product transfusion, preexisting @entity10 or @entity2 upon arrival. Primary outcome was mortality; secondary outcomes were early blood transfusion and neurosurgical intervention.Univariate analysis included Fisher exact and Wilcoxon rank-sum testing; we then performed logistic regression modeling and calculated adjusted odds ratios (AOR) to control for known predictors of poor outcome including @entity6 , @entity8 , @entity4 , @entity9 , and Head AIS. RESULTS: In 101 total subjects, 35% (n=35) had INR>= 1.3 on admission. On univariate analysis, @entity0 with @entity10 were more likely to have @entity8 , @entity6 , @entity4 , high @entity9 and low GCS (all p<0.05). There was no difference in age, @entity3 , and incidence of @entity7 . Overall mortality was 24.8% (n=25) which varied significantly based on admission INR (60% INR>= 1.3 vs 6% INR>1.3, p<0.001). @entity0 with elevated INR were also more likely to have early PRBC transfusion (p=0.003) and neurosurgical intervention (p=0.011). In logistic regression analysis, admission INR was the strongest independent predictor of mortality with increased odds of 3.65 (p=0.045). Adjusted odds ratio after controlling specifically for @entity6 , @entity8 and @entity4 was 6.25 (p=0.006) and after controlling for head AIS and admission GCS the AOR=5.27 (p=0.007). CONCLUSIONS: Admission INR>= 1.3 strongly predicts mortality in abusive @entity5 . These @entity0 should be targeted for early aggressive interventions and monitoring with the goal of improving @entity0 outcomes. Further study is warranted to investigate potential therapeutic targets in @entity1 -induced @entity10 . LEVEL OF EVIDENCE: III, prognostic and epidemiological.

title: Elevated admission INR strongly predicts mortality in victims of abusive XXXX .

answer: @entity5


abstract: OBJECTIVE: To analyze the success rates and prognosis of heart valvuloplasty and valve replacement for elderly @entity0 , and to provide clinical evidence. METHODS: A total of 1240 @entity0 who received heart valve surgeries in our hospital from June 2004 to October 2014 were selected and retrospectively analyzed. They were divided into two groups based on age (60), and those older than 60 (Group B) suffered from @entity5 and nonrheumatic @entity5 including @entity1 . Mitral valve replacement (MVR), tricuspid valve replacement (TVR), @entity10 ( @entity10 ), double valve replacement (DVR), @entity4 ( @entity4 ) and tricuspid valvuloplasty (TVP) were performed by using bioprosthetic and mechanical valves. Before surgery, coronary angiography, coronary artery bypass grafting (CABG), left @entity12 , left atrial wall folding and radiofrequency ablation were conducted. For the @entity0 younger than 60 (Group A) who had @entity3 , @entity5 and @entity5 , MVR, @entity10 , DVR, @entity4 , TVP and closed cuspid commissurotomy were performed with bioprosthetic and mechanical valves. The two groups were then monitored. RESULTS: The mortality rates of Group A and Group B were 2.7% (16 cases) and 3.1% (20 cases) respectively. They died mainly of malignant @entity11 , @entity9 , left @entity15 , @entity13 , @entity8 , @entity14 , upper @entity6 , mechanical valve failure and cerebrovascular accident. The two groups had significantly different application rates of bioprosthetic valve, times of auxiliary ventilation and hospitalization stay lengths (P<0.05), but left ventricular ejection fractions, left ventricular end-diastolic diameters (LVEDDs), mortality rates as well as times of aortic cross-clamping and cardiopulmonary bypass were similar (P>0.05). LVEDD, complicated @entity7 , CABG and grade of the New York Heart Association Functional Classification were independent risk factors for @entity2 . CONCLUSION: When heart valvuloplasty and valve replacement were performed for elderly @entity0 , the success rate and prognosis could only be improved by optimizing preoperative preparation, shortening the times of cardiopulmonary bypass and aortic cross-clamping, and paying particular attention to myocardial protection and postoperative treatment.

title: Success rates and prognosis of heart valvuloplasty and valve replacement performed for elderly XXXX .

answer: @entity0


abstract: UNASSIGNED: Global research knowledge has accumulated over the past few decades, and there is reasonable evidence for a positive association between @entity3 spp. @entity2 and @entity1 in @entity0 , although its role as a @entity0 pathogen has not been entirely accepted. For this reason, management of public health risk due to M.  @entity2 remains an important policy issue in agri-food public health arenas in many countries. Responsible authorities must decide whether existing mitigation strategies are sufficient to prevent or reduce @entity0 exposure to M.  @entity2 . A Web-based questionnaire was administered to topic specialists to elicit empirical knowledge and opinion on the overall public health impact of M.  @entity2 , the importance of various routes of @entity0 exposure to the pathogen, existing mitigation strategies and the need for future strategies. The questionnaire had four sections and consisted of 20 closed and five open questions. Topic specialists believed that M.  @entity2 is likely a risk to @entity0 health (44.8%) and, given the paucity of available evidence, most frequently ranked it as a moderate public health issue (40.1%). A significant correlation was detected between topic specialists' commitment to M.  @entity2 in terms of the number of years or proportion of work dedicated to this topic, and the likelihood of an extreme answer (high or low) to the above questions. Topic specialists identified contact with ruminants and dairy products as the most likely routes of exposure for @entity0 . There was consensus on exposure routes for ruminants and what commodities to target in mitigation efforts. Described mandatory programmes mainly focused on culling diseased animals and voluntary on-farm prevention programmes. Despite ongoing difficulties in the identification of @entity4 in animals, the topic specialists largely agreed that further enhancement of on-farm programmes in affected commodities by the agri-food industry (68.4%) and allocation of resources by governments to monitor the issue (92%) are most appropriate given the current state of evidence.

title: The potential Public Health Impact of XXXX ssp. @entity2 : Global Opinion Survey of Topic Specialists.

answer: @entity3


abstract: @entity1 is formed during cooking processes and is present in many foods. Accumulating evidence suggests that @entity2 is carcinogenic, but the underlying mechanism remains unclear. Here, we investigated the carcinogenesis mechanisms of @entity2 . @entity2 increased the @entity4 expression. Two major transcription factors, AP-1 and NF-kB, were activated by @entity2 treatment. @entity2 induced the ERK phosphorylation, and this was abolished by the treatment of @entity3 , a pharmacological inhibitor of @entity5 , an upstream kinase of ERK. @entity2 -induced expression and promoter activity of @entity4 were suppressed by @entity3 . @entity3 treatment attenuated @entity2 -induced transactivation of AP-1 and NF-kB, suggesting that the @entity5 /ERK signaling pathway regulates @entity4 expression. In addition, @entity0 , a natural inhibitor of the @entity5 /ERK signal pathway, reduced @entity2 -induced activation of the @entity4 promoter as well as activation of AP-1 and NF-kB. Collectively, these results suggest that the ability of @entity2 to up-regulate @entity4 expression through the @entity5 /ERK signaling pathway underlies @entity2 .

title: XXXX up-regulates cyclooxygenase-2 expression through the @entity5 /ERK signaling pathway in mouse epidermal cells.

answer: @entity1


abstract: BACKGROUND: We measured the functional and metabolic status of hearts submitted to normothermic @entity0 before preservation through the use of an ex  vivo @entity9 heart model to assess the feasibility of donation after @entity1 ( @entity11 ) in heart transplantation. METHODS: Ten @entity9 were separated into 2 groups: control (n  = 6, @entity8 group) and @entity11 (n  = 4, heart donation after @entity1 ). In the control group, hearts were excised 20 minutes after the brachiocephalic trunk cross-clamping and were immediately reperfused. In @entity11 , hearts were excised 20 minutes after exsanguination and @entity10 , stored in the Centre de R  sonance Magn  tique Biologique et M  dicale (CRMBM) solution for 2 hours, and then were reperfused. @entity5 was induced with the use of 1 L of CRMBM solution (4  C) and the heart was reperfused for 60 minutes through the use of an ex  vivo perfusion system in Langendorff mode with normothermic autologous blood. During reperfusion, functional parameters were analyzed. Biochemical assays were performed in myocardial effluents and freeze-clamped hearts. RESULTS: No electromechanical activity was found in @entity11 compared with control. @entity4 kinase (CK) was higher at 2 minutes of reperfusion in @entity11 versus control (P  = .005). @entity3 was lower in @entity11 versus control (P  = .0019). @entity6 , an oxidative stress index, was present only in @entity11 . The @entity2 (NO) pathway was impaired in @entity11 versus control, with lower eNOS expression (P  < .0001) and total @entity7 concentration content (P  = .04). CONCLUSIONS: We reported no cardiac functional and metabolic recovery in the @entity11 group after normothermic @entity0 and reperfusion, which indicates that a single immersion of the cardiac graft during storage does not provide an optimal protection. New strategies in heart preservation are necessary for recruiting heart donation after @entity1 .

title: Heart donation after @entity1 : preliminary study on an isolated, perfused XXXX heart after 20 minutes of normothermic @entity0 .

answer: @entity9


abstract: AIMS:     The aim of this study was to investigate and compare effective parameters for gastric electrical stimulation (GES) to modulate gastric muscle functions in different species. METHODS:     Four species: @entity5 , @entity3 , @entity2 , and @entity1 implanted with two pairs of electrodes on the serosal surface of the stomach were studied, respectively. Experiment 1 was designed to entrain/pace gastric slow waves and included a series of 5-min periods with long-pulse GES of different pulse widths and frequencies. Experiment 2 was designed to induce @entity4 with long-pulse GES of different frequencies. Gastric slow waves were recorded during the entire experiment. RESULTS:     1) The minimum pulse width for GES to completely entrain the slow waves was similar (100-400   msec) in all four species. 2) With fixed amplitude (4   mA) and pulse width (400   msec), the highest frequency at which slow waves could be paced was similar (about 10-60% higher than the intrinsic slow wave frequency) in all species. 3) With fixed pulse width of 400   msec and amplitude of 6   mA, GES with nine to 18 cycles per min (cpm) was able to induce @entity4 in @entity3 . In addition, there was no significant difference among these frequencies of 9-18   cpm. 4) GES with 400   msec, 6   mA, and 9   cpm was able to induce @entity4 in all species. These effective GES parameters in results 1-4 were similar to those used in @entity0 in the literature. CONCLUSIONS:     There is no significant difference in stimulation parameters when GES is applied to alter gastric slow waves in different animal models. Furthermore, the effective parameters for GES to alter slow waves are similar between the @entity0 and various animal models. These findings suggest that stimulation parameters obtained from animal studies are applicable in @entity0 .

title: Gastric electrical stimulation with long pulses in XXXX and animals: can data obtained in animals be replicated in @entity0 ?

answer: @entity0


abstract: PURPOSE: The purpose of this paper is to determine the repeatability of visual acuity measurement in @entity1 and to describe the impact of measurement repeatability on sample size. METHODS: Approximately 10% of a 1209 @entity0 sample in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study were selected randomly for a Repeat CLEK Study Visit. @entity0 were tested at the 15 CLEK Participating Clinics. The test-retest sample consisted of 1 34 @entity1 @entity0 who met the entry criteria of the CLEK Study. High and low contrast Bailey-Lovie visual acuity was measured with the @entity0 's habitual visual correction (entrance visual acuity monocularly and binocularly), and with the best correction monocularly (either the @entity0 's rigid contact lens and over-refraction, or with a CLEK Study trial lens and appropriate over-refraction) at two visits separated by a median of 90 days (range 22 to 268 days). RESULTS: The mean absolute differences between the number of letters correct at the two visits ranged from a low of 3.24 +/- 3.1 for entrance high contrast binocular acuity to a high of 5.48 +/- 5.1 for best corrected low contrast monocular acuity. Intraclass correlation coefficients ranged from 0.757 to 0.853. The visual acuity score was somewhat higher at the Repeat Visit than at the Baseline Visit when the examiners were different between visits. CONCLUSIONS: Given the variable vision reported by @entity1 @entity0 , visual acuity in this sample was very repeatable. Repeatability was slightly poorer when different examiners tested visual acuity at the Baseline and Repeat Visits.

title: Visual acuity repeatability in XXXX : impact on sample size. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group.

answer: @entity1


abstract: BACKGROUND: The cognitive fusion questionnaire (CFQ) is a self-report questionnaire that assesses the extent to which individuals are psychologically entangled with, and dominated by the form-content of their thoughts. The aim of this study was to replicate the factor structure of CFQ in @entity3 , @entity1 , @entity2 , @entity4 , and normative population. It further examined the factorial invariance of the CFQ across these 5 groups. METHOD: Data from 299 @entity0 (N General Population   =  67, N @entity3   =  73, N @entity1   =  47, N @entity4   =  45, and N Obesity   =  60) were subjected to confirmatory factorial analysis ( @entity6 ) to replicate the structural model of CFQ dimensionality. RESULTS: @entity6 supported a 1-factor structure with good internal consistency and construct related validity. The 1-factor solution was also supported by a second independent data set, which showed a configural, strict measurement, and structural invariance of the 1-factor solution proposed. Multigroup @entity6 showed the configural invariance, strict measurement invariance, and structural invariance of CFQ across the 5 groups under study. CONCLUSIONS: The unidimensional model has both similar meanings and the same structure, but the measurement model across the groups was not the same. The study provides the first approach to CFQ to Portuguese population, as a reliable tool of general cognitive fusion. Furthermore, results indicated that CFQ has a coherent structure across multiple samples and clinical utility, as it discriminate individuals with @entity5 from those who do not.

title: Validation of the psychometric properties of cognitive fusion questionnaire. A study of the factorial validity and factorial invariance of the measure among @entity3 , @entity1 , @entity2 , XXXX , and general populations.

answer: @entity4


abstract: UNASSIGNED: 1084 Background: @entity8 -associated @entity0 have pathologic features and biologic behavior that are distinct from @entity0 while @entity6 @entity2 are indistinguishable. Comparative survival studies have reported conflicting results and recent studies suggest relative resistance to @entity7 -based chemotherapy in @entity1 with @entity8 mutations. To determine if there are differences in long-term outcomes for @entity8 , @entity6 and high-risk non-carriers with @entity0 based on adjuvant therapy received, we conducted a retrospective analysis in US and Italian @entity1 . METHODS: @entity1 diagnosed with @entity0 between January 1, 1990 and December 31, 2008 were identified at the University of Chicago Cancer Risk Clinic and the Veneto Institute of Oncology in Padua. There were 80 @entity8 carriers, 78 @entity6 carriers and 177 high-risk non-carriers ascertained within the same time period. End points were @entity4 ( @entity4 ) and @entity4 ( @entity4 ) by type of adjuvant chemotherapy received. Hazard Ratios (HR) and 95% Confidence Intervals (95% CI) were calculated from Cox proportional hazard models. A multivariate analysis was used to adjust for year at diagnosis, stage, grade and @entity5 (ER) status. RESULTS: The median follow up was 4.98 (0.03-18.9). The @entity4 -adjusted hazard ratios were not significantly different among mutation carriers and non-carriers (HR among @entity8 carriers, 0.52; 95% CI, 0.21 to 1.31; HR among @entity6 carriers, 0.68; 95% CI, 0.31 to 1.48; P=0.326). The @entity4 -adjusted hazard ratios were not significantly different (HR among @entity8 carriers, 1.24; 95% CI, 0.45 to 3.45; HR among @entity6 carriers, 0.89; 95% CI, 0.33 to 2.38; P=0.837). Ten year survival was 78% for @entity8 , 83% for @entity6 and 92% for non-carriers, respectively. The risk of recurrence and @entity3 was also not statistically significant among @entity1 treated with different chemotherapy regimens. CONCLUSIONS: @entity4 and @entity4 survival are similar for carriers of a BRCA mutation and non-carriers.

title: Adjuvant chemotherapy in American and Italian @entity1 with XXXX /2-associated @entity0 .

answer: @entity8


abstract: Immune cells infiltrating the microenvironment of melanoma @entity1 may either limit or promote @entity2 progression, but the characteristics that distinguish these effects are obscure. In this study, we systematically evaluated the composition and organization of immune cells that infiltrated melanoma @entity1 in @entity0 @entity0 . Three histologic patterns of immune cell infiltration were identified, designated immunotypes A, B, and C. Immunotype A was characterized by no immune cell infiltrate. Immunotype B was characterized by infiltration of immune cells limited only to regions proximal to intratumoral blood vessels. Immunotype C was characterized by a diffuse immune cell infiltrate throughout a @entity1 . These immunotypes represented 29%, 63%, and 8% of @entity1 with estimated median survival periods of 15, 23, and 130 months, respectively. Notably, from immunotypes A to C, there were increasing proportions of B cells and decreasing proportions of macrophages. Overall, the predominant immune cells were T cells (53%), B cell lineage cells (33%), and macrophages (13%), with natural killer and mature dendritic cells only rarely present. Whereas higher densities of @entity4 (+) T cells correlated best with survival, a higher density of @entity5 (+) leukocytes, T cells, and B cells also correlated with increased survival. Together, our findings reveal striking differences in the immune infiltrate in melanoma @entity1 in @entity0 , suggesting microenvironmental differences in immune homing receptors and ligands that affect immune cell recruitment. These findings are important, not only by revealing how the immune microenvironment can affect outcomes but also because they reveal characteristics that may help improve individualized therapy for @entity0 with @entity3 .

title: Immunotype and immunohistologic characteristics of @entity2 -infiltrating immune cells are associated with clinical outcome in XXXX .

answer: @entity3


abstract: Scaling up of insecticide treated nets has contributed to a substantial @entity2 decline. However, some @entity2 vectors, and most arbovirus vectors, bite outdoors and in the early evening. Therefore, topically applied insect repellents may provide crucial additional protection against mosquito-borne pathogens. Among topical repellents, DEET is the most commonly used, followed by others such as @entity5 . The protective efficacy of two formulated @entity5 repellents against mosquito bites, including arbovirus and @entity2 vectors, was evaluated in a field study in Cambodia. Over a period of two years, @entity0 landing collections were performed on repellent treated @entity0 , with rotation to account for the effect of collection place, time and individual collector. Based on a total of 4996 mosquitoes collected on negative control @entity0 , the overall five hour protection rate was 97.4% [95%CI: 97.1-97.8%], not decreasing over time. @entity5 20% performed equally well as DEET 20% and better than @entity5 10%. Repellents performed better against Mansonia and Culex spp. as compared to aedines and anophelines. A lower performance was observed against @entity1 as compared to @entity4 , and against Anopheles barbirostris as compared to several vector species. Parity rates were higher in vectors collected on repellent treated @entity0 as compared to control @entity0 . As such, field evaluation shows that repellents can provide additional personal protection against early and outdoor biting @entity2 and arbovirus vectors, with excellent protection up to five hours after application. The heterogeneity in repellent sensitivity between mosquito genera and vector species could however impact the efficacy of repellents in public health programs. Considering its excellent performance and potential to protect against early and outdoor biting vectors, as well as its higher acceptability as compared to @entity3 , @entity5 is an appropriate product to evaluate the epidemiological impact of large scale use of topical repellents on arthropod borne diseases.

title: Field Evaluation of XXXX Repellents Reveals Differences in Repellent Sensitivity between Southeast Asian Vectors of @entity2 and Arboviruses.

answer: @entity5


abstract: BACKGROUND: Minimal @entity4 (MCNS) in @entity0 frequently is associated with @entity3 and immunoglobulin E production. T Helper subtype 2 cytokines, such as @entity5 ( @entity5 ), may have an important role in the development of @entity2 . We investigated the associations of gene polymorphisms of @entity9 ( @entity8 ), and the @entity6 ( @entity6 ) gene with MCNS. METHODS: We analyzed these polymorphisms in Japanese @entity0 with MCNS (n = 58) and healthy controls with neither allergic nor @entity1 (n = 63). The polymerase chain reaction (PCR) and restriction fragment length polymorphism method was used for the @entity5 promoter gene polymorphism ( @entity7 ), and PCR single-strand conformation polymorphism analysis was used for the @entity8 chain gene ( @entity10 ) and @entity6 3' untranslated region ( @entity11 ) polymorphisms. RESULTS: There was a significant difference between the MCNS group and controls in genotypic distribution of @entity5 promoter gene polymorphism. Frequency of the T allele was significantly lower in the MCNS group than controls. There was no difference between the MCNS group and controls in the @entity8 gene polymorphism. In the @entity6 gene, no significant differences in genotypic and allelic distribution were observed between the 2 groups. However, there were significant differences between @entity0 who did not need cytotoxic agents or who experienced 3 or fewer relapses and controls. CONCLUSION: These results suggest that genetic variations in the @entity5 and @entity6 genes may be associated with predisposition to MCNS, partially the clinical course of MCNS.

title: Polymorphisms of @entity5 --related genes in Japanese XXXX with minimal @entity4 .

answer: @entity0


abstract: UNASSIGNED: Objective. To explore whether GC (group-specific component) @entity5 , @entity6 , and @entity7 polymorphisms are associated with generalized aggressive @entity2 . Methods. This case-control study recruited 372 @entity0 with generalized aggressive @entity2 (group AgP) and 133 periodontal healthy subjects (group HP). GC @entity5 , @entity6 , and @entity7 genotypes and plasmatic @entity3 ( @entity4 ) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic @entity4 and haplotypes was analyzed. Results. GC @entity5 GG genotype was statistically associated with lower risk for generalized aggressive @entity2 under the recessive model (OR = 0.52, 95% CI: 0.30-0.92, p = 0.028). GC @entity5 and @entity6 had strong linkage disequilibrium with r(2) >=  0.8 and D' >=  0.8. Haplotype (GC @entity5 , @entity6 ) GC was associated with the less risk for generalized aggressive @entity2 (OR = 0.29, 95% CI: 0.09-0.96, p = 0.043). In group AgP, individuals with combined genotype (GC @entity5 , @entity6 ) AG+CA had significantly lower plasmatic @entity4 level than those with the other two combined genotypes (AG+CA versus AA+CC p = 0.007; AG+CA versus GG+AA p = 0.026). Conclusions. GC @entity5 genotype GG and haplotype (GC @entity5 , @entity6 ) GC are associated with generalized aggressive @entity2 . The association may be acquired through regulating @entity4 levels. The functions of GC gene and @entity4 in @entity1 need to be further studied.

title: GC Gene Polymorphisms and XXXX Levels Are Related to the Risk of Generalized Aggressive Periodontitis.

answer: @entity3


abstract: BACKGROUND: Extracorporeal shockwave therapy is a conservative treatment for several @entity6 . The aim of the study was the assessment of the relief from @entity2 by the shockwave therapy in a population of consecutive @entity0 affected by specific pathologies. MATERIALS AND METHODS: A group of consecutive @entity0 were studied and treated. They were affected by @entity3 of the shoulder (129 @entity0 ), @entity4 (102 @entity0 ), and @entity5 of the elbow (80 subjects). Each @entity0 had 3 applications with a monthly interval, and was followed up at 1, 6, and 12  months after treatment. Results were evaluated by the numeric rating scale (NRS) in all cases, the Constant Murley Score for the assessment of the shoulder function, the American Orthopaedic Foot and Ankle Society Score for subjects affected by @entity4 , and the Oxford Elbow Score for those affected by a @entity5 of the elbow. RESULTS: One year after treatment, the results were considered satisfactory with an almost complete resolution of symptoms. There were statistically significant results at the 12-month follow-ups regarding the mean NRS score (from 6.25 to 0.2), the Constant Murley Score (from 66.7 to 79.4), the Oxford Elbow Score (from 28 to 46), and the AOFAS (from 71 to 86). CONCLUSIONS: Extracorporeal shockwave therapy may be considered a safe, economic, and effective treatment for several chronic @entity1 , allowing satisfactory @entity2 relief and improvement of function ability. LEVEL OF EVIDENCE: Level IV.

title: Effectiveness of extracorporeal shockwave therapy in three major XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate the effect of @entity5 extract (GBE) on preexisting @entity2 in @entity0 with normal tension @entity3 (NTG). DESIGN: Prospective, randomized, placebo-controlled, double-masked cross-over trial. @entity0 : Twenty-seven @entity0 with bilateral @entity2 resulting from NTG. INTERVENTION: @entity0 received 40 mg GBE, administered orally, three times daily for 4 weeks, followed by a wash-out period of 8 weeks, then 4 weeks of placebo treatment (identical capsules filled with 40 mg @entity4 ). Other @entity0 underwent the same regimen, but took the placebo first and the GBE last. Visual field tests, performed at baseline and at the end of each phase of the study, were evaluated for changes. MAIN OUTCOME MEASURES: Change in visual field and any @entity1 . RESULTS: After GBE treatment, a significant improvement in visual fields indices was recorded: @entity6 ( @entity6 ) at baseline versus @entity6 after GBE treatment, 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB (t = 8.86, P = 0.0001, chi-square test); corrected pattern standard deviation (CPSD) at baseline versus CPSD after GBE treatment, 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB (t = 9.89, P = 0.0001, chi-square test). No significant changes were found in intraocular pressure, blood pressure, or heart rate after placebo or GBE treatment. Any ocular and systemic side effects were recorded for the duration of the trial. CONCLUSIONS: @entity5 extract administration appears to improve preexisting @entity2 in some @entity0 with NTG.

title: Effect of XXXX extract on preexisting @entity2 in normal tension @entity3 .

answer: @entity5


abstract: OBJECTIVE: Infantile @entity7 is a lethal @entity1 . Current developments toward enzyme replacement therapy are promising. The aim of our study is to delineate the natural course of the disease to verify endpoints of clinical studies. METHODS: A total of 20 infantile @entity0 diagnosed by the collaborative Dutch centers and 133 cases reported in literature were included in the study. Information on clinical history, physical examination, and diagnostic parameters was collected. RESULTS: The course of @entity7 is essentially the same in the Dutch and the general @entity0 population. Symptoms start at a median age of 1.6 months in both groups. The median age of death is 7.7 and 6 months, respectively. Five percent of the Dutch @entity0 and 8% of all reported @entity0 survive beyond 1 year of age. Only 2 @entity0 from literature became older than 18 months. A progressive @entity6 is characteristic for @entity7 . The diastolic thickness of the left ventricular posterior wall and cardiac weight at autopsy increase significantly with age. Motor development is severely delayed and major developmental milestones are generally not achieved. For the Dutch @entity0 group, growth deviates significantly from normal despite start of nasogastric tube feeding. Levels of @entity2 aminotransferase, @entity3 aminotransferase, @entity4 dehydrogenase, @entity5 kinase, or @entity5 kinase-myocardial band isoenzyme are typically elevated, although @entity2 aminotransferase, @entity3 aminotransferase, and @entity4 dehydrogenase increase significantly with age. The @entity0 have fully deleterious mutations. Acid alpha-glucosidase activity is severely deficient. CONCLUSIONS: Survival, decrease of the diastolic thickness of the left ventricular posterior wall, and achievement of major motor milestones are valid endpoints for therapeutic studies of @entity7 . Mutation analysis and measurement of the alpha-glucosidase activity should be part of the enrollment program.

title: The natural course of XXXX : 20 original cases compared with 133 cases from the literature.

answer: @entity7


abstract: The N @entity0 oligodendroglial cell line, immortalized with SV40 T antigen, simultaneously expresses oligodendroglial markers and @entity5 ( @entity5 ), an astroglial marker. This study examines the plasticity of N @entity0 cells with regard to @entity5 expression, and its relationship to expression of SV40 T antigen, @entity2 , and a novel nuclear antigen detected by the A007 monoclonal antibody. Marked changes occur in @entity5 levels and cell morphology when N @entity0 cells are switched from the permissive temperature (34 degrees C) to the non-permissive temperature (39 degrees C), and with @entity3 elevation at 39 degrees C. At 34 degrees C, levels of @entity5 are high; when cells are switched to 39 degrees C, @entity5 levels decrease significantly, then increase slightly when @entity4 is added. At both temperatures, the cells display feathery @entity5 immunostaining. When @entity4 is added at 39 degrees C, however, cells display bright fibrous @entity5 staining in elongated processes. The changes in @entity5 were compared to changes in T antigen and @entity2 . As expected, the decrease in T antigen at 39 degrees C was accompanied by movement of @entity2 from the nucleus to cytoplasm. Total @entity2 levels did not change, however, and @entity4 did not alter the respective distribution or levels of @entity2 at either temperature. At both temperatures, the cell bodies and processes show internal expression of sulfatide, as demonstrated with the O4, Sulph I, and A007 antibodies. We show, for the first time, abundant nuclear immunoreactivity with the A007 monoclonal antibody in the N @entity0 cells. This nuclear reactivity is seen at 34 degrees C, but not at 39 degrees C, similar to @entity2 , and is not detected with the other @entity6 antibodies. Double-label immunostaining shows that the nuclear A007 immunoreactivity is co-localized in nuclear structures with T antigen and @entity2 at 34 degrees C, but is not found in every nucleus containing these antigens. We conclude that regulation of @entity5 expression and morphology in N @entity0 cells is dependent on a combination of T antigen expression and level of @entity1 and may be related to regulation of @entity2 and the A007 nuclear antigen.

title: Regulation of CNS glial phenotypes in N XXXX cells.

answer: @entity0


abstract: BACKGROUND: Although the standard of care after recurrence of @entity2 ( @entity2 ) is chemotherapy, increasing data suggest that combining cytoreductive surgery with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising option for @entity0 with recurrent @entity2 . Our aim was to determine the prognostic value of the addition of HIPEC to secondary cytoreductive surgery (SCR) in recurrent @entity2 . METHODS: We analyzed a series of 79 @entity0 with @entity5 -sensitive recurrent @entity2 who were treated from May 2000 to January 2014. Fifty @entity0 who underwent SCR were compared to 29 who had SCR in combination with HIPEC. RESULTS: The SCR group had a higher median age (58.4  years) compared to the SCR  +  HIPEC group (51.6  years) (p  =  0.006). The median hospital stay length was longer for SCR  +  HIPEC versus SCR @entity0 (11 and 8  days, respectively; p  =  0.009). More subjects experienced National @entity1 Institute grade III-IV morbidity in the SCR  +  HIPEC group (34.5  %) compared to the SCR group (10.6  %) (p  =  0.015). Conversely, there were no deaths in the SCR  +  HIPEC group and 2 (4.0  %) deaths the SCR group. The median disease-free survival did not differ between SCR and SCR  +  HIPEC @entity0 (18.6 and 15.8  months, respectively; p  =  0.82); nor did median overall survival (59.3 and 58.3  months, respectively; p  =  0.95). The presence of @entity3 was the only variable that remained linked to a higher risk of recurrence and @entity4 in the multivariate analysis. CONCLUSIONS: Our data suggest that the addition of HIPEC to cytoreduction in @entity0 with recurrent @entity5 -sensitive @entity2 does not improve survival.

title: Hyperthermic Intraperitoneal Chemotherapy after Secondary Cytoreduction in XXXX : A Single-center Comparative Analysis.

answer: @entity2


abstract: BACKGROUND: The psychopathological and clinical characteristics of adult @entity0 with @entity3 attending our neurology clinic were evaluated to determine prevalence of psychopathology and its associated factors towards improving services and initiating collaborative care which is currently nonexistent. METHODS: The study was a two-stage procedure conducted over 1 year using the General Health Questionnaire in the first stage and Schedule for Clinical Assessment in Neuropsychiatry in the second stage. Diagnosis of @entity1 was based on International Classification of Diseases: 10th Revision criteria. RESULTS: Sixty-three @entity0 were interviewed. Mean age was 34.43    13.7 years; more than half of the @entity0 had less than one @entity6 episode per month. Fourteen @entity0 (22.2%) had @entity3 ; 40 (63.5%), generalized; and 9 (14.3%), unclassified @entity6 . The rate of @entity1 morbidity was found to be 28.6%. @entity5 were the most common (66.7%), followed by @entity7 (11.1%), @entity2 (11.1%) and @entity4 (11.1%). Psychopathology was more common in @entity0 (P=.007), those older than 40 years (P=.038) and those with @entity3 (P=.017). CONCLUSION: About one third of @entity0 with @entity3 studied had undetected and untreated psychopathology. Our neurology clinic urgently needs currently nonexistent collaborative care involving neurologists, psychiatrists and primary care physicians in order to improve the mental health of the @entity0 with @entity3 .

title: Prevalence and clinical implications of psychopathology in adults with XXXX seen in an outpatient clinic in Nigeria.

answer: @entity3


abstract: PURPOSE: We generated a @entity4 -conjugated @entity6 nanoparticle (porphysome) suitable for multimodal non-invasive active macrophage tracking @entity1 ( @entity1 ). PROCEDURES: Macrophage uptake of @entity4 -conjugated porphysomes was selective. @entity4 -porphysome cardiac macrophage tracking was detected in vivo using radioligand and fluorescent imaging. To track post- @entity1 macrophage mobilization, cardiac fluorescence signal in @entity4 -porphysome-injected @entity0 was measured for 9  day post- @entity1 . Active macrophage phenotype was assessed using immunohistochemistry. RESULTS: Heart active macrophage presence peaked on day 1, returned to baseline by day 3, and peaked again on day 7 post- @entity1 . Macrophages were distributed throughout the left ventricle at day 1, but aggregated within scar tissue at day 7. Macrophage phenotype was pro-inflammatory ( @entity2 (+)) at day 1, whereas scar-resident macrophages expressed anti-inflammatory markers ( @entity5 , @entity3 ) at day 7. However, day 7 macrophages outside the scar expressed neither pro- nor anti-inflammatory markers. CONCLUSIONS: We established that @entity4 -porphysomes are suitable for non-invasive imaging of macrophages and used it to investigate active macrophage behavior in the infarcted heart.

title: Non-invasive Macrophage Tracking Using Novel Porphysome Nanoparticles in the Post- XXXX @entity0 Heart.

answer: @entity1


abstract: Authors present comparison of the previous results on the influence of free @entity3 of the @entity6 in @entity1 and @entity0 on the pH of the @entity6 in vitro. Four clinically used antiglaucomatics were added (2% Trusopt--pH 5.33; 0,005% Xalatan--pH 6.4; 0.5% @entity5 --pH 6.80 and 1% @entity4 --pH 5.87) into the aquired @entity6 of @entity1 (pH 7.59) and @entity0 (pH 7.11 +/- 0.11). After their instillation pH of the @entity6 immediately decreased towards acid levels. The pH changes after @entity5 , Xalatan and @entity4 showed a similar time pattern and after return to the baseline values the pH shifted to alkaline levels. In case of Trusopt instillation the pH value reached the baseline of the @entity6 after 240 min. Almost no pH changes were recorded from 240 min up to 24 hours after all tested antiglaucomatics. From the wiev on the speed of activity and effectivity depending on time required to reach the initial pH value of the @entity6 we to make this order: @entity4 > @entity5 >Xalatan>Trusopt. Comparing our results the effect of antiglaucomatics is connected with different composition and also with shift of the @entity7 towards slightly alkaline level (similar effect in @entity1 and @entity0 ). Results presented in this work are theoretical but also practical contribution to the treatment of @entity2 . (Fig. 1, Ref. 38.).

title: The free @entity3 and the XXXX after antiglaucomatics in vitro.

answer: @entity7


abstract: INTRODUCTION: The 90-day risk of @entity4 in @entity0 with @entity8 ( @entity8 ) is estimated at between 8% and 20%. There is little consensus as to which diagnostic strategy is most effective. This study evaluates the benefits of early transthoracic echocardiography (TTE) with carotid and transcranial Doppler ultrasound in @entity0 with @entity8 . METHODS: Prospective study of @entity0 with @entity8 in an emergency department setting. Demographic data, vascular risk factors, and @entity9 ) score were analysed. @entity8 aetiology was classified according to TOAST criteria. All @entity0 underwent early vascular studies (<72hours), including TTE, carotid ultrasound, and transcranial Doppler. Primary endpoints were recurrence of @entity1 or @entity8 , @entity6 ( @entity6 ), or @entity2 during the first year. RESULTS: We evaluated 92 @entity0 enrolled over 24 months. Mean age was 68.3  13 years and 61% were male. The mean @entity9 ) score was 3 points (>= 5 in 30%). The distribution of @entity8 subtypes was as follows: 12% large-artery @entity7 ; 30% cardioembolism; 10% small-vessel occlusion; 40% undetermined cause; and 8% rare causes. Findings from the early TTE led to a change in treatment strategy in 6 @entity0 (6.5%) who displayed normal physical examination and ECG findings. At one year of follow-up, 3 @entity0 had experienced @entity1 (3.2%) and 1 @entity0 experienced @entity6 (1%); no vascular @entity2 were identified. CONCLUSIONS: In our @entity8 @entity0 , early vascular study and detecting @entity0 with silent @entity3 may have contributed to the low rate of @entity5 recurrence.

title: Rapid diagnosis and treatment of @entity8 results in low rates of @entity1 , @entity6 and XXXX .

answer: @entity2


abstract: Severe @entity2 is an infrequent symptom in the course of lumbar @entity3 . The objectives of this study are threefold: to describe the @entity1 , evaluate the prognosis factors, and determine the type of @entity3 most likely to be complicated by motor loss. Fifty consecutive @entity0 with a mean age of 65 years, operated on for @entity5 and with a severe @entity1 , have been retrospectively studied with a mean follow-up of 38 months. The overall functional result was evaluated according to the Beaujon scoring system. The motor capacity was rated from 0 (complete paralysis) to 5 (normal strength). Prognosis factors were investigated with a multivariate analysis model. Motor weakness was rated as zero 11 times, as one 8 times, as two 8 times, and as three 23 times. According to our rating scale, the overall results were considered excellent in 25 cases, good in 17 cases, and fair in the 8 remaining cases. @entity2 was complete 15 times, partial 25 times, and null 10 times. In this study, favorable prognosis parameters of @entity2 recovery were as follows: association with a discal herniation, @entity3 at one level, preoperative duration of @entity2 <6 weeks, age <65, and monoradicular deficit. In contrast, severity of the initial @entity2 , association with @entity4 , presence or not of degenerative spondylolisthesis, or of a complete block on the myelogram were not influential variables.

title: @entity1 in @entity5 : a retrospective study of a series of 50 XXXX .

answer: @entity0


abstract: UNASSIGNED: This paper presents the first ever paleodontological investigation of @entity0 remains from an archeological site in Central Europe dating from the Early Bronze Age and attributed to the Strzyzow Culture. It corroborates the knowledge gained from archeological, anthropological and genetical investigations. Our study aimed to assess dental status, dental morphology and dental pathologies as well as @entity4 and @entity2 based on visual inspection and stereomicroscopic investigation. The research was supported by CBCT imaging to obtain digital images and 3D reconstructions as well as 2D radiographs essential for dental age estimation. All of the 191 teeth discovered showed morphological similarity, with adult teeth showing similar color, shape and size. A maxillary molar presenting with a unique root morphology and a mandibular molar with a rare occlusal surface were found. Both permanent and deciduous dentition presented significant @entity4 . A few specimens displayed signs of @entity1 , periapical pathology and antemortem @entity3 . Three individuals exhibited @entity2 . CBCT provided high-quality 2D images useful for dental age estimation by non-destructive methods. Estimated dental age correlated with the age estimated by other anthropological methods. In one case, this was crucial because of insufficient material for anthropological analysis. The presented studies have proved that besides the skeleton, teeth can be used as a fundamental tool in assessing the overall health and living conditions of paleopopulations. It would seem that there is potential for considerable development to be made in the research and investigation of paleodontological material using CBCT.

title: Analysis of XXXX dentition from Early Bronze Age: 4000-year-old puzzle.

answer: @entity0


abstract: The purpose of this study was to establish an efficient combination of assisted hatching and cryopreservation procedures for producing @entity0 embryos in vitro. A total of 1312 day 7 blastocysts were subjected randomly to 14 different combinations of three factors: osmotic stress, assisted hatching and vitrification. Re-expansion, initiation and completion of the hatching process, as well as attachment to the culture dish, were analysed by SAS Genmod procedure. Incubation with @entity1 was found to decrease survival rates; among the assisted hatching procedures used, zona fenestration resulted in higher survival rates compared with partial zona dissection and controls; and vitrification decreased survival and further development. The combined effect of @entity1 incubation and vitrification decreased further development markedly, as did partial zona dissection followed by vitrification. Partial zona dissection performed in medium containing @entity1 severely lowered embryo survival. Zona fenestration without @entity1 incubation followed by vitrification did not compromise further embryo development: 86%, 84% and 79% of the blastocysts initiated, completed hatching and attached to the bottom, respectively. These data were not different from the controls (80%, 76% and 63%, respectively; P > 0.05). Cell count analysis revealed a decrease in the total number of cells as a result of the assisted hatching and vitrification compared with controls (135 versus 202, respectively; P < 0.0001). Although embryo transfer results (36% pregnancy rate and 30% calving rate) require further improvement, this combination of methods may prove useful in the commercial production of @entity0 embryos in vitro.

title: Survival and development of XXXX blastocysts produced in vitro after assisted hatching, vitrification and in-straw direct rehydration.

answer: @entity0


abstract: PURPOSE: To evaluate a @entity4 -like finding in an eye with @entity1 using anterior-segment optical coherence tomography (AS-OCT). METHODS: A 35-year-old @entity0 complained of sudden-onset @entity3 . She had been diagnosed with @entity2 at 1.5 years old and the onset of secondary @entity1 was identified at 13 years old. At the age of 26 years, transscleral contact diode laser cyclophotocoagulation therapy was performed, except for the upper quadrant, because scleral thinning was noted at that time. At the age of 35 years, she was blind in her right eye and @entity5 and a @entity4 -like structure in the upper conjunctiva was seen with a slit-lamp examination. This @entity4 -like structure was removed surgically at bulbar exenteration, and the pathology was examined. RESULTS: AS-OCT showed a @entity4 -like internal structure with a single large empty space and thin scleral tissue and relatively thin walls with high optical density. Pathology indicated that the high optical density @entity4 wall was connective tissue. On AS-OCT, the internal surface of the empty space was very smooth, which matched the pathology. Histochemically, there were goblet cells, as in normal conjunctiva, but not in the conjunctiva over the aqueous space. CONCLUSIONS: AS-OCT images found that the intrableb structure was in good agreement with the pathology results; these conjunctival changes were very similar to those after a standard trabeculectomy.

title: Bleb-like Finding Caused by Idiopathic Scleral Thinning in an Eye With XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the response rates, toxicitiesy, and survival rates, to @entity7 ( @entity7 (R)), @entity5 and @entity8 combination chemotherapy, of the @entity0 with inoperable NSCLC (stage III and IV), who received @entity7 ( @entity7 (R)), @entity5 , @entity8 combinationthe mentioned chemotherapy every 4 weeks. MATERIALS AND METHODS: This study included 26 @entity0 with inoperable NSCLC (stage III and IV), who attended St. Vincent's Hospital Bbetween April 1999 and December 2001, 26 @entity0 were included at St.Vincent's Hospital. The chemotherapy regimen consisted of @entity7 (25 mg/m2 on days 1 and 8), @entity8 (1,500 mg/m2 on days 1- and 2 with @entity10 ), and @entity5 (30 mg/m2 on days 1- to 3). The cycles were administered every 4 weeks. A 25% reduction in the doses reduction was applied into subsequent courses if there werewas grade 3~4 @entity9 . RESULTS: The median age was 63 (range, 44~73) years and the male : to female ratio was 19 : 7. One @entity0 had stage IIIa, 6 had stage IIIb and 19 had stage IV. Twenty two @entity0 had an ECOG performance status of 0 or 1, andwith 4 hadhave one of 2. Eighteen of the @entity0 had @entity3 , 7 had @entity6 , and 1 had an undifferentiated NSCLC. Two @entity0 were innot able to be evaluatedble due to follow-up loss. Among Of the 24 @entity0 able to be evaluatedble @entity0 , 1 @entity0 had a complete response and 9 @entity0 hada partial responses, and thewith an overall response rate wasof 41.7%. During a total of 104 cycles, grade 3 @entity9 occurred in 29%, grade 4 @entity9 in 12%, grade 3~4 @entity4 in 4%, grade 3 @entity2 in 11%, and grade 3~4 @entity1 in 2%. The mean time to progression was 6.4 months (range 1~13) and the median overall survival was 10 months (range 1.5~32). CONCLUSION: The combination of @entity7 , @entity8 and @entity5 , in the dose and schedule employed in this study, shows an response rate of 41.7%, but, because grade 3- or 4 @entity9 occurred in 41%, a careful investigation is needed.

title: Effect of @entity7 , @entity8 and XXXX Combination Chemotherapy in Stage III-IV Non-Small-Cell Lung Cancer.

answer: @entity5


abstract: BACKGROUND: Despite the progress that has been achieved in the last years, recurrence rates in @entity1 @entity0 are still considerably high and the majority of @entity0 ultimately become candidates for second-line treatment. @entity6 reinduction is a broadly adopted regimen in @entity0 with recurrences occurring six months or later after first-line treatment. @entity2 is among the candidates as combination partner in second-line regimens. @entity0 AND METHODS: We performed a study with escalating doses of @entity2 combined with @entity6 in 26 @entity5 -pretreated @entity0 with recurrent @entity1 and a treatment-free interval of 6+ months. Dose-limiting @entity3 (DLT) and a maximum tolerable dose (MTD) recommendable for further trials was evaluated. RESULTS: The DLT was myelosuppression, mainly @entity4 . No dose limiting non-hematological @entity3 were observed. The MTD of @entity2 was 1,000 mg/m2 given on days 1 + 8 of a three-week schedule combined with @entity6 AUC 4 given on day 1. The majority of evaluable @entity0 showed an objective response (62.5%), and median progression-free and overall survival were 10 and 18+ months, respectively. CONCLUSION: @entity2 - @entity6 given according to the MTD is well tolerated and active against recurrent @entity5 -sensitive disease. A randomized trial comparing @entity6 with or without @entity2 in @entity5 -sensitive @entity1 has already been initiated.

title: Second-line XXXX and @entity2 in @entity5 sensitive @entity1 --a dose-finding study by the Arbeitsgemeinschaft Gyn  kologische Onkologie (AGO) @entity1 Study Group.

answer: @entity6


abstract: @entity6 may be removed without using a surgical incision by a combination of techniques and skills recently developed in the fields of urology and radiology. Percutaneous access to the kidney is established under fluoroscopic control. A guide wire placed into the renal pelvis allows a nephroscope to be inserted and the collecting system visualized. A long hollow metal probe is advanced through the nephroscope and placed in contact with the stone. This probe conducts the ultrasonic energy. The stone absorbs the energy and breaks into fine granules which are evacuated by suction. Percutaneous lithotomy was performed upon 300 of 302 consecutive @entity0 bearing stones which required removal. Targeted calculi were successfully removed from 97 per cent of these @entity0 . Eighty-one per cent had complete stone removal at the primary procedure; 57 @entity0 required additional percutaneous manipulations under local or general anesthesia. The previous 100 @entity0 with @entity6 underwent surgical removal of the calculi. Complications associated with percutaneous stone removal included @entity2 , delayed @entity5 , ureteral @entity1 , symptomatic urinary extravasation and @entity7 . Only 16 @entity0 with complications required prolonged hospitalization or readmission. No complications required surgical management; no @entity4 occurred. Anesthetic times were similar for both groups, averaging 152 +/- 4 (S. E. M.) minutes for PL and 193 +/- 8 minutes for SL. Hospital recovery days averaged 5.7 +/- 0.3 for PL and 8.4 +/- 0.5 for SL (p less than 0.01). Associated costs averaged  7,203 +/- 255 for PL and  8,849 +/- 660 for SL (p less than 0.01). The number of narcotic administrations per @entity0 (days one to five postoperatively) averaged 9.9 +/- 0.7 for the PL group and 16.8 +/- 0.8 for the SL group (p less than 0.01). The average @entity0 in the PL group felt capable of full activity 2.0 +/- 0.2 weeks after stone removal, whereas no @entity0 who experienced previous SL recalls a recovery period of less than three weeks (p less than 0.01). Most upper urinary tract calculi may be removed cost-effectively using a percutaneous approach. @entity0 may expect a rapid convalescence with diminished @entity3 .

title: Percutaneous ultrasonic versus surgical XXXX .

answer: @entity6


abstract: BACKGROUND: The @entity4 Optimal Treatment (HOT) Study has provided information about @entity3 in 18790 @entity4 , subjected to pronounced blood pressure (BP) lowering for a mean of 3.8 years. The HOT study data have subsequently been analysed after stratification of the @entity0 according to global cardiovascular risk, and it has been found that, despite intensive blood pressure lowering in all risk strata, morbid event rates increased with increasing risk stratum. OBJECTIVES: Previously analysed global risk strata were based on combinations of risk factors. The analyses presented here were intended to provide information on the relative role that the presence of each individual factor may have in increasing cardiovascular risk, despite good BP control. METHODS: Risk ratios (RR) for @entity0 with and those without a risk factor were calculated with 95% confidence intervals (CI) using a Cox proportional hazard model, and adjusted for all variables except the one under examination. RESULTS: For all risk factors considered and for all types of event, RR were always greater than 1, indicating a greater risk in the presence, compared with that in the absence of each factor. The male gender was a statistically significant risk for cardiovascular (CV) events, CV and total mortality and particularly for @entity7 ( @entity7 ); age > or = 65 years for CV events, @entity2 , CV and particularly total mortality; smoking for all events analysed, but particularly for total mortality (twice higher in smokers than in non-smokers); high serum @entity5 (> 6.8 mmol/l) for CV events, @entity7 and CV mortality; high serum @entity8 (> 155 micromol/l) for CV events, @entity2 , CV and total mortality; @entity1 for CV events, @entity2 , total mortality and particularly CV mortality; and @entity6 for all events analysed. Adjusted RR were often close to or greater than 2. CONCLUSIONS: Each of the risk factors considered was found to be an important cause of residual risk, despite good BP control. These findings emphasize the importance of addressing other correctable risk factors, e.g. smoking, hypercholesterolaemia and @entity1 , as well as rigorous control of blood pressure, and of initiating antihypertensive therapy before cardiovascular and renal damage becomes manifest.

title: Effects of individual risk factors on the incidence of @entity3 in the treated @entity4 XXXX of the @entity4 Optimal Treatment Study. HOT Study Group.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: In clinical practice a concomitant boost is usually given as a second daily dose to a reduced field. The question arises which part of treatment should be accelerated to achieve @entity0 control. An experiment was performed on @entity0 bearing @entity1 to determine the optimal timing of treatment acceleration for this experimental @entity0 system. MATERIAL AND METHODS: @entity2 R1H of the @entity1 were treated applying 30 fractions in an overall treatment time of 40-42 days, up to total doses ranging from 67.5 to 97.5 Gy were administered. For control a standard treatment was given as continuous treatment applying one fraction per day. A boost of five additional fractions was given as a second fraction during 5 days. Three experimental arms received a boost either in the 1st, 4th, or in the last week of treatment. Treatment outcome was assessed using @entity0 control as endpoint. RESULTS: All experimental arms proved more effective than the standard treatment. Treatment was most effective when the boost was administered in the 1st week of treatment. A TCD37% of 87.1 Gy (95% CI: 82.8 ... 92.7 Gy), 96.5 Gy (89.9 ... 107.1), and 107.3 Gy (97.2 ... 131.0) was determined, when the boost was given in the 1st, 4th, or last week of treatment, respectively. The observed difference between the experimental arms was statistically significant (p = 0.004). CONCLUSIONS: Initially accelerated treatment schedules were found to be more effective for @entity0 control in an experimental @entity0 system.

title: Impact of treatment acceleration and its timing on the response of the @entity2 R1H of the XXXX to fractionated irradiation.

answer: @entity1


abstract: OBJECTIVES: Caring for a @entity0 with @entity3 is a real challenge and can have considerable psychological consequences in the long run. Many caregivers, mostly relatives, feel highly burdened. To develop effective caregiver support to prevent caregivers from getting overburdened, insight is needed into the determinants of burden. The objective of this study is to explore which @entity0 and caregiver characteristics determine the different kinds of caregiver burden over time, both in the short and in the long run. METHOD: The study was longitudinal. Data on @entity0 and caregivers, general @entity2 were collected at three times: at baseline, at the end of treatment and at nine months. The study was conducted in a @entity1 skilled nursing home with a unit for integrative reactivation and rehabilitation (IRR) and at different sites of home-/day care, assisted living arrangements and nursing home wards (usual care). RESULTS: General burden is shown to be determined by severity of @entity0 's neuropsychiatric symptoms, caregiver's sense of competence, health-related quality of life. @entity2 is determined by severity of @entity0 's neuropsychiatric symptoms, caregiver's sense of competence, high affiliation and @entity0 gender. CONCLUSION: In preventing or treating caregiver burden, professional interventions need to aim specifically at diminishing the neuropsychiatric symptoms in @entity3 @entity0 and improving the sense of competence in caregivers.

title: Do determinants of XXXX in @entity3 caregivers change over time?

answer: @entity2


abstract: UNASSIGNED: @entity6 is common worldwide. Furthermore, the @entity2 ( @entity2 ) signaling pathway is considered to be constitutively activated in @entity0 . @entity3 is widely accepted as an antitumor drug as it effectively inhibits the cell cycle. This study predominantly explores the possible molecule mechanism of @entity3 on @entity0 treatment. Cell viability was first detected using an @entity1 assay. Cell apoptosis was examined by Hoechst staining and flow cytometry using an @entity8 and @entity7 kit. Specific @entity2 signaling pathways were further explored through western blot analysis. Abnormal protein expression levels were determined via immunofluoresence. Additionally, the protein levels of @entity4 and 9 were determined using ELISA. @entity3 significantly inhibited @entity0 cell viability in a time- and dose-dependent manner. @entity3 also enhanced @entity0 cell apoptosis via increased Bim and @entity9 protein expression. Furthermore, @entity3 was observed to inhibit @entity0 cell proliferation through increased @entity4 and @entity5 protein levels. @entity3 inhibited the growth of the @entity0 cell line, tea8113 malignant proliferation and enhanced tea8113 cell apoptosis through inhibiting the @entity2 signaling pathway.

title: XXXX induces apoptosis and reduces proliferation by targeting @entity2 signaling pathway in oral cavity squamous cell carcinoma.

answer: @entity3


abstract: Of the multiplicity of plant pathogens in nature, only a few are virulent on a given plant species. Conversely, plants develop a rapid "nonhost" resistance response to the majority of the pathogens. The anatomy of the nonhost resistance of @entity0 endocarp tissue against a pathogen of bean, @entity2 @entity1 . phaseoli (Fsph) and the susceptibility of @entity0 to @entity2 @entity1 . pisi (Fspi) has been described cytologically, biochemically and molecular-biologically. Cytological changes have been followed by electron microscope and stain differentiation under white and UV light. The induction of changes in transcription, protein synthesis, expression of pathogenesis-related (PR) genes, and increases in metabolic pathways culminating in low molecular weight, antifungal compounds are described biochemically. Molecular changes initiated by fungal signals to host organelles, primarily to chromatin within host nuclei, are identified according to source of the signal and the mechanisms utilized in activating defense genes. The functions of some PR genes are defined. A hypothesis based on this data is developed to explain both why fungal growth is suppressed in nonhost resistance and why growth can continue in a susceptible reaction.

title: Anatomy of a nonhost disease resistance response of XXXX to @entity2 : PR gene elicitation via DNase, chitosan and chromatin alterations.

answer: @entity0


abstract: UNASSIGNED: This study aimed to examine the association between @entity1 ( @entity1 ) and @entity2 among young adults. A total of 2911 college students in Thailand participated in the study. Anthropometric measurements and blood pressure were taken by trained research staff. Overall, 6.3% of college students had @entity1 determined by the Berlin Questionnaire, 9.6% were overweight (BMI: 25-29 kg/m(2)), 4.5% were @entity2 (BMI>= 30 kg/m(2)); 12.4% had @entity4 ( @entity0 : waist circumference>= 90 cm; @entity0 : waist circumference>= 80 cm). There were significant associations between @entity1 and overweight (odds ratio (OR)=1.72; 95% confidence interval (CI)=1.04-1.85) and @entity2 (OR=24.23; 95% CI=15.20-38.61), independent of demographic and lifestyle factors, blood pressure, and @entity3 . Students with @entity1 were more likely to have @entity4 than those without @entity1 (OR=2.09; 95% CI=1.19-3.67). @entity1 was significantly related to joint effects of general and @entity4 . The @entity1 associations were robust and evident for both genders, individuals with normal and elevated blood pressure, and those with and without @entity3 . This study shows independent associations of @entity1 with general and @entity4 among young adults. @entity1 could be a risk factor for @entity2 and consequent cardiovascular morbidities. @entity1 screening and treatment might be important for young adults.

title: Obstructive Sleep Apnea and Multiple Anthropometric Indices of General Obesity and XXXX among Young Adults.

answer: @entity4


abstract: UNASSIGNED: Accumulating evidence strongly suggests that dysregulation of long noncoding RNAs (lncRNAs) is associated with @entity0 @entity3 . The lncRNA @entity5 transcript at the distal tip ( @entity6 ) is involved in the development of several @entity1 . However, the biological role of @entity6 in @entity2 ( @entity2 ) has not yet been discussed. Here, we report that @entity6 acts as a functional oncogene in the pathogenesis of @entity2 . In this study, quantitative polymerase chain reaction (qPCR) was performed to detect the expression of @entity6 in 48 pairs of @entity2 samples. We found that overexpression of @entity6 is correlated with an advanced pathological stage and a larger @entity1 size. Moreover, functional analyses revealed that the knockdown of @entity6 expression by small interfering RNA (siRNA) or small hairpin RNA (shRNA) could inhibit cell proliferation and induce cell apoptosis. More importantly, we observed that @entity6 knockdown induced a marked increase in the number of cells in the G0/G1 phase and a reduction in the number of cells in the S phase in both DLD-1 cells and SW480 cells. An in vivo experiment also revealed that the knockdown of @entity6 inhibited @entity1 growth. Western blot and immunohistochemistry analyses indicated that @entity6 potentially contributed to @entity2 cell growth partially through the silencing of @entity4 expression. Collectively, our results suggest that @entity6 is involved in the progression of @entity2 and may provide evidence for @entity6 being a target for therapy of this disease.

title: The long noncoding RNA XXXX transcript at the distal tip promotes @entity2 growth partially via silencing of @entity4 expression.

answer: @entity5


abstract: @entity13 is a small molecule antiangiogenic agent that inhibits @entity2 ( @entity2 ) stimulation of the @entity7 @entity10 kinase receptor. In this Phase I dose escalation trial, a weekly dose schedule of @entity13 was tested whereby an initial 5-day loading dose was followed by weekly maintenance infusions. The start dose was 20 mg/m(2) for the loading dose followed by 65 mg/m(2) for the weekly infusions. Dose escalations occurred at 33% until a final dose of 65 mg/m(2) (loading dose) and 190 mg/m(2) (weekly infusion) was obtained. Twenty-two @entity0 were treated at five dose levels; @entity1 types included gastrointestinal (8), breast (3), lung (4), @entity6 (2), and other (5). The most common serious drug-related @entity4 was @entity3 , often associated with @entity8 and @entity9 . Grade 1 and 2 @entity4 included @entity3 , @entity8 , @entity9 , @entity11 , @entity5 at the infusion site, @entity12 , change in voice, and fevers. Of 19 evaluable @entity0 , 4 obtained clinical benefit as defined by @entity1 regression (1) or disease stabilization for at least 12 weeks (3). Pharmacokinetic data revealed that the weekly infusion schedule prevented the reported 50-60% induction in @entity13 clearance observed with either daily or twice weekly dosing. Higher baseline levels of urine @entity2 were observed in the 4 @entity0 who gained clinical benefit, suggesting this may be a useful marker for predicting response to anti- @entity2 therapies. Our results suggest that a weekly schedule of @entity13 shows signs of biological activity and is well tolerated at doses up to 145 mg/m(2).

title: Results of a Phase I dose-escalating study of the antiangiogenic agent, @entity13 , in @entity0 with advanced XXXX .

answer: @entity1


abstract: PURPOSE: To  apply a novel self-gating k-space sorted 4-dimensional MRI (SG-KS-4D-MRI) method to overcome limitations due to anisotropic resolution and rebinning artifacts and to monitor @entity2 motion. METHODS AND MATERIALS: Ten @entity0 were imaged using 4D-CT, cine 2-dimensional MRI (2D-MRI), and the SG-KS-4D-MRI, which is a spoiled gradient recalled echo sequence with 3-dimensional radial-sampling k-space projections and 1-dimensional projection-based self-gating. @entity1 volumes were defined on all phases in both 4D-MRI and 4D-CT and then compared. RESULTS: An isotropic resolution of 1.56  mm was achieved in the SG-KS-4D-MRI images, which showed superior soft-tissue contrast to 4D-CT and appeared to be  free of stitching artifacts. The @entity1 motion trajectory cross-correlations (mean      SD)  between SG-KS-4D-MRI and cine 2D-MRI in superior-inferior, anterior-posterior, and medial-lateral directions were 0.93      0.03, 0.83      0.10, and 0.74      0.18, respectively. The @entity1 motion trajectories cross-correlations between SG-KS-4D-MRI and 4D-CT in superior-inferior, anterior-posterior, and medial-lateral directions were 0.91      0.06, 0.72      0.16, and 0.44      0.24, respectively. The average standard deviation of gross @entity1 volume calculated from  the 10 breathing phases was 0.81  cm(3) and 1.02  cm(3) for SG-KS-4D-MRI and 4D-CT, respectively (P=.012). CONCLUSIONS: A novel SG-KS-4D-MRI acquisition method capable of reconstructing rebinning artifact-free, high-resolution 4D-MRI images was used to quantify @entity1 motion. The resultant @entity2 motion trajectories agreed well with 2D-cine-MRI and 4D-CT. The @entity2 volumes shown in the different phases for the SG-KS-4D-MRI were statistically significantly more consistent than those in the 4D-CT.

title: Four-Dimensional Magnetic Resonance Imaging  With 3-Dimensional Radial Sampling and Self-Gating-Based K-Space Sorting: Early Clinical Experience on XXXX @entity0 .

answer: @entity2


abstract: BACKGROUND: Previous studies found relations between @entity0 and minerals in drinking water, but the major works considered water hardness or neglected the differences between adults and elderly. Drinking water is an important source of @entity2 in the elderly particularly because of increased needs and decreased consumption of dairy products. METHODS: We collected informations about all @entity1 (14,311) occurring in 69 parishes of the South-West of France during 7 years (1990-1996). We obtained the causes of @entity1 from a special service of INSERM for each @entity1 , with age at @entity1 and sex. The exposure value was supplied by administrative source (DDASS) and by measurement surveys. We use an extra-Poisson variation model to take into account the heterogeneity of the population of these parishes. RESULTS: A significant relationship was observed between @entity2 and @entity0 with a RR: 0.90 for non-cerebrovascular causes and RR: 0.86 for cerebrovascular (when @entity2 is higher than the second tercile: 94 mg/l). We found a protective effect of @entity3 concentrations between 4 and 11 mg/l with a RR: 0.92 for non-cerebrovascular and RR: 0.77 for cerebrovascular mortality, as compared to concentrations lower than 4 mg/l. CONCLUSIONS: These findings strongly suggest a potential protective dose-effect relation between @entity2 in drinking water and cardiovascular causes. For @entity3 , a U-shape effect is possible, especially for cerebrovascular mortality.

title: @entity0 and @entity2 and XXXX in drinking water: an ecological study in elderly people.

answer: @entity3


abstract: The safety and efficacy of myeloablative therapy followed by autologous peripheral blood stem cell transplantation (ABSCT) for @entity6 ( @entity6 ) were evaluated in 60 @entity0 . Peripheral blood stem cells (PBSC) were collected during recovery after consolidation chemotherapy. High-dose chemotherapy consisting of @entity3 (16 mg/kg), @entity5 (40 mg/kg), and @entity4 (3 g/m2 x 4) (BEA regimen) was used for pretransplant conditioning in 13 @entity0 . For the remaining 47 @entity0 , @entity2 ( @entity2 ) was administered concurrently with the BEA regimen during conditioning. Unpurged, cryopreserved PBSC containing a median number of 5.4 x 10(8) MNC/kg or 12 x 10(4) CFU-GM/kg were reinfused at transplantation. The median number of days to granulocytes exceeding 500/microl and last platelet transfusion were 15 (8-44) and 24 (0->180), respectively. The 3-year probabilities of disease-free survival (DFS) and relapse were 78.6 and 21.4% for @entity0 transplanted in first remission, 29.6 and 64.4% for those in second or third remission, and 11.1 and 77.8% for those in relapse, respectively. There were no transplant-related @entity1 within 100 days of transplantation. Age, disease status at transplantation, and number of induction chemotherapies to first complete remission were risk factors affecting the outcome of ABSCT. These results of ABSCT for @entity6 in first remission warrant a prospective study of ABSCT as post-remission therapy.

title: Autologous peripheral blood stem cell transplantation for XXXX .

answer: @entity6


abstract: The paramyxovirus genome, a nonsegmented, negative-polarity, single-stranded RNA of approximately 15 kb, contains six transcription units flanked at the 3' and 5' ends by a short (approximately 50- to 60- @entity0 ) extracistronic sequence, dubbed the positive and negative leader regions. These leader template regions, present at the 3' end of the genome and the antigenome, have been shown to contain essential signals governing RNA replication activity. Whether they are sufficient to promote replication is still open to question. By using a series of @entity2 defective interfering RNAs carrying a nested set of deletions in the promoter regions, it is shown here that for both the genomic and antigenomic promoters, a 3'-end RNA sequence of 96 @entity1 is required to allow replication. Sequence comparison of active and inactive promoters led to the identification of a set of three @entity0 hexamers ( @entity1 79 to 84, 85 to 90, and 91 to 96) containing a repeated motif RXXYXX [shown as 5'-3' positive-strand]. Sequential mutation of each hexamer into its complementary sequence confirmed their essential role. The three hexamers are required, and their relative positioning is important, since displacing them by 6 @entity1 destroyed promoter function. RNAs carrying degenerate @entity1 in the three hexamers were used as replication templates. They led to the selection of actively replicating RNA species exclusively carrying the basic motif (GNNNNN)3 from @entity1 79 to 96. These results clearly show that, apart from the region from @entity1 1 to 31, previously identified as governing @entity2 replication activity, a second element, spanning at the most @entity1 79 to 96, appears essential. Thus, the paramyxovirus replication promoters are not confined to the leader template regions, as seems to be the case for the rhabdoviruses.

title: The activity of XXXX genomic and antigenomic promoters requires a second element past the leader template regions: a motif (GNNNNN)3 is essential for replication.

answer: @entity2


abstract: UNASSIGNED: The @entity3 are the embryological precursors of the face, neck and pharynx. Anomalies of the @entity3 are the second most common congenital lesions of the head and neck in @entity0 , with second @entity5 by far the most common. Clinically, these @entity1 may present as cysts, sinus tracts, fistulae or cartilaginous remnants with typical clinical and radiological findings. We review the normal embryological development of the @entity3 and the anatomical structures of the head and neck that derive from each arch. The typical clinical and radiological appearances of both common and uncommon @entity5 are discussed with an emphasis on @entity4 . KEY POINTS:     Anomalies of the @entity3 usually present as cysts, sinuses or fistulae.     Second @entity5 account for approximately 95  % of cases.     There are no pathognomonic imaging features so diagnosis depends on a high index of suspicion and knowledge of typical locations.     Persistent cysts, fistulae or recurrent @entity2 may be due to @entity5 .     Surgical excision of the cyst or tract is the most common curative option.

title: XXXX : a pictorial review of embryological development and spectrum of imaging findings.

answer: @entity4


abstract: BACKGROUND: Pleural effusion may complicate acute Stanford type B aortic dissection ( @entity5 ). AIMS: To identify the relationships between the quantity and side of the @entity4 , biomarkers and outcomes in @entity0 with @entity5 . METHODS: We undertook a retrospective review of 105 @entity0 with @entity5 . Their demographics, the data on admission and during hospital stay, the volume of @entity4 calculated from the area on computed tomography images and clinical outcomes were analysed. RESULTS: The median estimated peak volume (median 6.7 days after onset) was 129 ml (63-192, range 26-514 ml) on the left and 11 ml (6-43, range 2-300 ml) on the right. On univariate analysis, the volume of bilateral effusions was associated with @entity3 , hypoalbuminaemia and inflammatory markers, whereas the volume of left-sided effusions was associated with older age, low diastolic blood pressure and maximum aortic diameter. Multivariate analysis revealed that hypoalbuminaemia was independently associated with bilateral effusion volume (P<0.001), while maximum aortic diameter was associated with left-sided effusion volume (P=0.019). A greater volume of bilateral plural effusion was associated with longer intensive care unit stay. CONCLUSIONS: Larger bilateral @entity4 in @entity0 with @entity5 were associated with hypoalbuminaemia and potentially with @entity3 and @entity1 , and may increase the length of intensive care unit stay. Left-sided effusion volume appears to be influenced by the nature of the @entity2 . Multiple mechanisms may underpin the development of @entity4 in @entity5 , and are likely to influence clinical outcomes.

title: Clinical implications of XXXX in @entity0 with acute type B aortic dissection.

answer: @entity4