abstract: OBJECTIVE: This is a retrospective study aimed at clarifying the details of recurrence patterns and sites in @entity0 with @entity1 treated with definitive @entity3 ( @entity3 ). METHODS: Data were analyzed from consecutive @entity0 , admitted to our institution between 2001 and 2013, who had received definitive @entity3 , with or without chemotherapy, for International Federation of Gynecology and Obstetrics stages IB. @entity1 . RESULTS: One hundred and thirty-seven @entity0 formed the @entity0 cohort. The median follow-up period for surviving @entity0 was 57.0 months. A complete response was achieved in 121 (88%) @entity0 . Of these, 36 (30%) developed a @entity1 recurrence during follow-up. The first sites of recurrence were located in intra- @entity3 fields in nine, outside @entity3 fields in 20, and both in seven @entity0 . In the intra- @entity3 field group, all @entity0 showed a local recurrence, while no one experienced an isolated @entity4 ( @entity4 ) recurrence. In the outside @entity3 field group, the most frequent site of recurrence was lung (60%), and three-quarters of @entity0 were free from intra- @entity3 field recurrence until the last follow-up. Of the entire cohort, including 48 @entity4 -positive @entity0 , only seven (5.1%) @entity0 developed @entity4 persistence or recurrence, all in the common iliac, internal iliac, and/or obturator nodes, and all with another synchronous relapse. CONCLUSION: @entity2 was a major type of intra- @entity3 field recurrence, while @entity4 control was favorable even in initially @entity4 -positive @entity0 . The predominance of outside @entity3 field recurrence alone highlights issues concerning distant control, including the intensity enhancement of systematic therapy.

title: Details of recurrence sites after definitive @entity3 for XXXX .

answer: @entity1


abstract: UNASSIGNED: 270 Background: @entity10 kinase inhibitors (TKI), such as @entity8 , @entity9 and @entity12 , have replaced immunotherapy as the standard of care for metastatic @entity7 (mRCC). However, their use in sequential or combined strategies is limited by the lack of evidences on the ability of TKIs to induce cell death in @entity0 cells. Aim of our study was to evaluate the different mechanisms responsible of the cytotoxic effects induced in vitro by   M doses of @entity8 , @entity9 and @entity12 in 5637 and J82 @entity3 ( @entity3 ) cell lines. METHODS: The viability of @entity3 cell lines were tested by @entity2 assay. Autophagy was evaluated by western blot analysis with the anti-LC3 and anti- @entity16 antibodies, @entity14 staining and cytofluorimetric analysis. @entity1 and apoptosis, (    m) dissipation and ROS generation were determined by @entity11 /PI, JC-1 and @entity17 staining, respectively and cytofluorimetric analysis. The @entity4 activity was evaluated by ELISA. Finally, by mRNA estraction and RT-PCR array the @entity12 -induced gene profile expression was evaluated. RESULTS: We found that treatment of 5637 and J82 @entity3 cells with the three TKI agents markedly reduced cell viability. Treatment for 24 h with @entity8 and @entity9 at 20   M dose, triggers an incomplete autophagy of @entity3 cells. In addition, inhibition of autophagy induced by @entity8 and @entity9 triggers cell death of @entity3 cells. Thus, @entity8 by imparing the @entity4 activity induces lysosomal-dependent @entity1 . Similarly, @entity9 by defective lysosomial degradation triggers ROS- and mitochondrial-dependent apoptosis. As regard to @entity12 , we first demonstrate that treatment of @entity3 cells for 72 hrs (20   M) induces autophagic Type II cell death, which was markedly reversed in a dose-dependent manner by @entity13 and @entity5 autophagic inhibitors. Finally, @entity12 upregulates the mRNA expression of a-glucosidase (GAA) and @entity15 belonging to the @entity6 @entity0 suppressor genes. CONCLUSIONS: Overall, our results showing different TKI-induced cell death mechanisms provide the rationale for the sequential use of these agents and the biological basis for novel molecularly targeted approaches.

title: Different effects of @entity8 , XXXX , and @entity12 on inducing @entity0 cell death: The role of autophagy.

answer: @entity9


abstract: BACKGROUND: @entity4 -resistant @entity5 has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to @entity4 . This study was designed to establish the baseline values for clearance in @entity0 from Sub-Saharan African countries with uncomplicated @entity1 treated with @entity4 -based combination therapies (ACTs). METHODS: A literature review in PubMed was conducted in March 2013 to identify all prospective clinical trials (uncontrolled trials, controlled trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. Individual @entity0 data from these studies were shared with the WorldWide Antimalarial Resistance Network (WWARN) and pooled using an a priori statistical analytical plan. Factors affecting early parasitological response were investigated using logistic regression with study sites fitted as a random effect. The risk of bias in included studies was evaluated based on study design, methodology and missing data. RESULTS: In total, 29,493 @entity0 from 84 clinical trials were included in the analysis, treated with @entity7 - @entity8 (n   =   13,664), @entity3 - @entity9 (n   =   11,337) and @entity6 - @entity10 (n   =   4,492). The overall parasite clearance rate was rapid. The parasite positivity rate (PPR) decreased from 59.7  % (95  % CI: 54.5-64.9) on day 1 to 6.7  % (95  % CI: 4.8-8.7) on day 2 and 0.9  % (95  % CI: 0.5-1.2) on day 3. The 95th percentile of observed day 3 PPR was 5.3  %. Independent risk factors predictive of day 3 positivity were: high baseline parasitaemia (adjusted odds ratio (AOR)   =   1.16 (95  % CI: 1.08-1.25); per 2-fold increase in parasite density, P <0.001); fever (>37.5    C) (AOR   =   1.50 (95  % CI: 1.06-2.13), P   =   0.022); severe @entity2 (AOR   =   2.04 (95  % CI: 1.21-3.44), P   =   0.008); areas of low/moderate transmission setting (AOR   =   2.71 (95  % CI: 1.38-5.36), P   =   0.004); and treatment with the loose formulation of @entity3 - @entity9 (AOR   =   2.27 (95  % CI: 1.14-4.51), P   =   0.020, compared to @entity6 - @entity10 ). CONCLUSIONS: The three ACTs assessed in this analysis continue to achieve rapid early parasitological clearance across the sites assessed in Sub-Saharan Africa. A threshold of 5  %  day 3 parasite positivity from a minimum sample size of 50 @entity0 provides a more sensitive benchmark in Sub-Saharan Africa compared to the current recommended threshold of 10  % to trigger further investigation of @entity4 susceptibility.

title: Clinical determinants of early parasitological response to ACTs in African XXXX with uncomplicated falciparum malaria: a literature review and meta-analysis of individual @entity0 data.

answer: @entity0


abstract: Posterior cingulate cortex is the site of earliest reductions in @entity2 metabolism and qualitatively different laminar patterns of @entity0 in @entity1 ( @entity1 ). This study used multivariate analyses of area 23 in 72 cases of definite @entity1 to assess relationships between laminar patterns of @entity0 , @entity6 ( @entity6 ) and @entity3 ( @entity3 ) densities, age of disease onset and duration, and @entity5 ( @entity5 ) genotype. No age-related changes in neurons occurred over four decades in 17 controls and regression analysis of all @entity1 cases showed no relationships between neuron, @entity3 , and tau-immunoreactive @entity6 densities. Principal components analysis of neurons in layers III-Va and eigenvector projections showed five subgroups. The subgroups were independent because each had a full range of disease durations and qualitatively different laminar patterns in degeneration suggested disease subtypes (ST). Cases with most severe neuron losses (STSevere) had an early onset, most @entity3 , and highest proportion of @entity5 epsilon4 homozygotes. Changes in the distribution of @entity6 were similar over disease course in two subtypes and @entity6 did not account for most @entity0 . In STII-V with moderate @entity4 in most layers, cases with no @entity6 had a disease duration of 3.5 +/- 0.9 years (mean +/- SEM), those with most in layers IIIc or Va had a duration of 7.3 +/- 1 years, and those with most in layers II-IIIab had a duration of 12.1 +/- 1 years. In STSevere, cases with highest @entity6 densities in layers II-IIIab also were late stage. Finally, epsilon4 homozygotes were most frequent in STSevere, but four statistical tests showed that this risk is not directly involved in @entity0 . In conclusion, multivariate pattern recognition shows that @entity1 is composed of independent neuropathological subtypes and @entity6 in area 23 do not account for most neuron losses.

title: Multivariate analysis of laminar patterns of @entity0 in posterior cingulate cortex in XXXX .

answer: @entity1


abstract: BACKGROUND: BMI is one factor that is used to determine a @entity0 's eligibility for lipid screening and treatment. BMI, which is an indirect measure of body fat, may inadequately represent the biological effect of body fat percentage on lipid concentrations. OBJECTIVE: We examined the relation between directly measured body fat percentage and lipid concentrations in a representative sample of US youths. DESIGN: Data from 7821 @entity0 aged 8-19 y from the 1999-2004 NHANES were analyzed. Body fat percentage was measured by dual-energy X-ray absorptiometry. Total and HDL- @entity1 concentrations were measured in serum. Serum @entity2 and LDL- @entity1 concentrations were measured in a subsample of 2661 fasting NHANES @entity0 aged 12-19 y. Prevalences of adverse total @entity1 (>200 mg/dL), LDL @entity1 (>130 mg/dL), @entity3 (>150 mg/dL), and HDL @entity1 (<35 mg/dL) were measured. RESULTS: Approximately 10.0% [  0.7% (SE)] of @entity0 had high total @entity1 , 7.0    0.4% of @entity0 had low HDL @entity1 , 9.7    1.0% of @entity0 had high @entity3 , and 7.6    0.7% of @entity0 had high LDL @entity1 . Prevalence of adverse total @entity1 , HDL @entity1 , @entity3 , and LDL @entity1 in US youths with high adiposity (greater than or equal to the age- and sex-specific 75th percentile of body fat percentage) was significantly greater (P < 0.01) than for @entity0 without high adiposity. In multiple linear regressions adjusted for age, survey period, and race-ethnicity, the variance in lipid concentrations explained by body fat percentage was 2-20% (P < 0.001). CONCLUSION: Adverse lipid concentrations and high adiposity are significantly associated in youths.

title: Association of body fat percentage with lipid concentrations in XXXX and adolescents: United States, 1999-2004.

answer: @entity0


abstract: BACKGROUND: The primary purpose of the current study was to determine prospective associations of accelerometer-assessed physical activity intensity and sedentary time with health-related quality of life (HRQOL) indicators among survivors of @entity0 . METHODS: A total of 358 survivors of @entity0 wore an accelerometer for 7 days at baseline to assess different activity intensities (light, lifestyle, and moderate to vigorous) and sedentary behavior. Six months later, survivors completed online questionnaires that assessed HRQOL indicators (disease-specific @entity3 , and @entity2 ) and relevant covariates. Relationships between activity and sedentary behavior quartiles and HRQOL indicator scores were examined using generalized liner models with Bonferroni multiple comparison adjustment. RESULTS: After adjustment for covariates and sedentary time, each increasing lifestyle activity quartile was associated with @entity5 (P for trend, .03). Each increasing baseline moderate-to-vigorous physical activity (MVPA) quartile was found to be significantly associated with higher Physical Well-Being, Functional Assessment of @entity1 Therapy-Breast (FACT-B) total, and trial outcome index scores; fewer @entity0 -specific concerns; and lower @entity4 interference, and these differences were statistically and clinically significant between survivors in quartile 1 and quartile 4. After controlling for covariates and MVPA, relationships between sedentary time and HRQOL were mostly null with the exception of lower @entity4 duration. CONCLUSIONS: Objectively measured MVPA was found to be positively associated with many HRQOL indicators. Lifestyle activity was found to be only inversely associated with @entity4 duration whereas sedentary time was found to be positively associated with @entity4 duration. Future research is warranted to explore these relationships further. @entity1 2015;121:4044-4052.    2015 American @entity1 Society.

title: Objectively measured physical activity and sedentary behavior and quality of life indicators in survivors of XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity2 ) have a high cure rate, but we currently lack the ability to accurately identify the small subset of @entity0 who will die from their disease. We used a combined genomic and expression profiling approach to identify genomic regions and underlying genes that are predictive of outcome in @entity2 @entity0 . We performed array-based comparative genomic hybridization (CGH) on 53 non-seminomatous GCTs (NSGCTs) treated with @entity1 based chemotherapy and defined altered genomic regions using Circular Binary Segmentation. We identified 14 regions associated with two year disease-free survival (2yDFS) and 16 regions associated with five year disease-specific survival (5yDSS). From corresponding expression data, we identified 101 probe sets that showed significant changes in expression. We built several models based on these differentially expressed genes, then tested them in an independent validation set of 54 NSGCTs. These predictive models correctly classified outcome in 64-79.6% of @entity0 in the validation set, depending on the endpoint utilized. Survival analysis demonstrated a significant separation of @entity0 with good versus poor predicted outcome when using a combined gene set model. Multivariate analysis using clinical risk classification with the combined gene model indicated that they were independent prognostic markers. This novel set of predictive genes from altered genomic regions is almost entirely independent of our previously identified set of predictive genes for @entity0 with NSGCTs. These genes may aid in the identification of the small subset of @entity0 who are at high risk of poor outcome.

title: Development and Validation of a Gene-Based Model for Outcome Prediction in XXXX Using a Combined Genomic and Expression Profiling Approach.

answer: @entity2


abstract: It is unknown what disadvantages are faced by @entity0 deciding for a prosthodontic treatment by inexperienced students. Commonly, the related extra effort and time are compensated by cost reduction of treatment fees. Thereby, the dental schools subsidize treatments to teach clinical prosthodontics. The aim of this study was to clarify the benefits to @entity0 as well as the efforts of the dental school. Data collected from three courses in a dental school in Germany were @entity0 gender, age, occupation, @entity2 code, number of visits, scope of treatment including costs, financial discount, and remaining copayment. Travel costs were calculated based on @entity2 code. Balance of travel costs and treatment discount was defined as financial benefit. The results showed that 185 @entity0 (95 male) aged 32 to 82 years (median=58) were treated with fixed restorations (FR, n=110), @entity1 ( @entity1 , n=87), @entity1 ( @entity1 , n=17), or other (RD, n=3). The mean number of visits was 11 for FR, 12 for @entity1 , and 9 for @entity1 . Single distance to the clinic ranged from 0.6 to 65 miles (median=12). Total costs of prosthodontics were reduced by 19% on average. The mean financial benefit was 429 USD (median=298, min=-482, max=4025). The financial benefits were found to differ widely, including additional expenditures of @entity0 . Participation, travel burden, and copayment did not depend on age, gender, or occupation. The financial benefit was relativized because students needed at least twice the sessions of a dentist. As a result, the financial efforts of dental schools are significant and compromise a cost-covering education.

title: Clinical Teaching of Prosthodontics in Undergraduate Courses in a German Dental School: XXXX , Visits, Efforts, and Incentives.

answer: @entity0


abstract: We have previously shown that metastatic @entity1 of unknown primary site overexpress several @entity0 markers as well as the products of the oncogenes @entity2 , ras and @entity5 . We analyzed the tissue expression of the protein products of the apoptosis modulation genes @entity4 and @entity3 in 47 CUP cases. Formalin-fixed, paraffin embedded @entity0 specimens were stained with commercially available antibodies to @entity4 (DO7) and @entity3 after antigen retrieval by the microwave method. Staining was evaluated by intensity (1+ to 3+), percentage of positive cells (1-100%), and the 'intensity times percentage' product defined as the immunoreactivity index with values ranging from 0 to 300. Immunoreactivity index values higher than 150 were considered to characterize protein over-expression. Expression of @entity4 was identified in 70.2% of @entity0 while 53% of them showed a high immunoreactivity index. @entity3 expression was detected in 65% of @entity0 and overexpressed in 40%. Overexpression of both proteins was detected in 20% of @entity0 . The detection of either protein was not associated with any of the major clinicopathological variables studied. Nevertheless, a trend towards a more favourable response to platin based chemotherapy was seen in the cases that showed a strong expression of both proteins, when analysed by immunoreactivity index and percentage of positive cells. We conclude that CUP overexpress at a high percentage the @entity4 and the @entity3 proteins. The observed weak association of strong expression of these proteins with response to platin-based chemotherapy deserves further evaluation in the CUP setting.

title: @entity3 and @entity4 protein expression in XXXX of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study.

answer: @entity1


abstract: UNASSIGNED: A 74-year-old @entity0 underwent coronary artery bypass graft surgery. Thirteen years later, he presented with complaints of exertional anterior chest oppression again. Computed tomography coronary angiography revealed the significant @entity4 at the mid right coronary artery (RCA). In addition, a giant proximal left anterior descending (LAD) @entity2 ( @entity2 ) was found. We did not observe this @entity1 on his previous coronary angiogram, performed 12 years previously (i.e., 1 year after his surgery). Diagnostic coronary angiography confirmed the computed tomography findings. We found the significant @entity4 at the mid RCA site and a giant proximal @entity2 . First, we performed the percutaneous coronary intervention (PCI) at the mid RCA significant @entity4 . We implanted the drug eluting stent. After that, we performed PCI to treat the giant proximal @entity2 with a covered stent (a 2.8/26-mm @entity3 covered stent), and complete exclusion of the @entity1 was obtained. The etiology of this @entity0 's @entity1 was unclear, but we speculate that the mechanism responsible for the appearance of this @entity1 was the expansion of the intra-plaque cavity with the ruptured fibrous cap. This observation over time through coronary angiography suggests that giant CAAs might be generated asymptomatically under certain conditions. In this case, the possible conditions might have been the chronic total occlusion of the mid-LAD and the significant @entity4 just distal to this @entity1 , so increasing flow and pressure against this diseased cavity might have caused this giant @entity2 to form. In addition, another speculation might have been the local inflammation or macrophage-based degradation after coronary artery bypass graft surgery.

title: Generation of a XXXX from an intra-plaque cavity with a ruptured fibrous cap: an observation over time through coronary angiography.

answer: @entity2


abstract: OBJECTIVE: To investigate the use of a quantitative diffusion-weighted imaging (DWI) tool for measuring @entity1 of the sacroiliac joints (SIJs) in enthesitis-related @entity3 (ERA). METHODS: A retrospective study was performed with institutional review board approval. Subjects were adolescents who had undergone MRI of the SIJs since January 2010. 10 @entity0 with a clinical diagnosis of ERA and 10 controls with a clinical diagnosis of mechanical back @entity2 were assessed. Axial T1 weighted, short tau inversion recovery (STIR) and DWI (b-values 0, 50, 100, 300 and 600   mm(2)   s(-1)) images were acquired. Apparent diffusion coefficient (ADC) maps were generated using a monoexponential fit. On each of four slices, two to three linear regions-of-interest were placed on each joint. Normalized ADC (nADC) values were defined as joint ADC divided by a reference ADC derived from normal sacral bone. STIR images were scored using a modification of an established technique. The correlation between nADC values and STIR scores was evaluated using Spearman's rank correlation. RESULTS: Mean nADC values were significantly higher in cases than in controls (p   =   0.0015). There was a strong correlation between STIR scores and nADC values (R   =   0.85). CONCLUSION: ADC values are significantly increased in inflamed SIJs compared with controls. There is a good correlation between this diffusion-based method and STIR scores of @entity1 . Advances in knowledge: We have described and provisionally validated a method for quantifying the severity of @entity1 in the SIJs in ERA using ADC measurements. This method is quick, is reproducible and could potentially be automated.

title: A diffusion-based quantification technique for assessment of sacroiliitis in adolescents with enthesitis-related XXXX .

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficacy, safety and tolerability of fixed dose combination of @entity5 (enteric-coated, EC) 20 mg + @entity3 (sustained release, SR) 30 mg for treatment of @entity4 ( @entity4 ). DESIGN: A prospective, single centre, open-label, non-comparative, observational study SETTING: The study was conducted at an otolaryngology clinic in India between May 2012 and November 2012. @entity0 : @entity0 (>18 yrs) with suspicious LPR-related symptoms, @entity2 ( @entity2 ) score >13 and @entity1 ( @entity1 ) >7, willing to undergo rigid laryngoscopy and requiring fixed dose combination of @entity5 (enteric-coated, EC) 20 mg + @entity3 (sustained release, SR) 30 mg capsule treatment according to the investigator's discretion were eligible for enrolment in the study. METHODS: Fixed dose combination of @entity5 (enteric-coated, EC) 20 mg + @entity3 (sustained release, SR) 30 mg capsule treatment was given for a total duration of 90 days and efficacy was assessed by the change in @entity1 and @entity2 score at Day 90. The safety and tolerability of the study drug was assessed by monitoring adverse events, vital signs and physical examination. RESULTS: Overall, 50 @entity0 were enrolled and completed the study. After 12 weeks of fixed dose combination of @entity5 (enteric-coated, EC) 20 mg + @entity3 (sustained release, SR) 30 mg capsule treatment there was a significant change in mean @entity2 scores [mean (SD) @entity2 : 19.18 (3.24) at baseline to 2.52 (2.31) at end of study; (p<0.0001)] as well as mean @entity1 score [mean (SD) @entity1 : 12.62 (1.48) at baseline to 0.30 (0.51) at end of study; (p<0.0001)]. No adverse event was reported by any @entity0 during the study period. CONCLUSION: Twelve weeks of treatment with combination of fixed dose combination of @entity5 (enteric-coated, EC) 20 mg + @entity3 (sustained release, SR) 30 mg capsule significantly improved reflux symptoms in @entity0 with LPR. The combination was found to be safe and well tolerated.

title: An Open Label, Prospective, Single Centre Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of @entity5 (Enteric-Coated, EC) 20 mg + @entity3 (Sustained Release, SR) 30 mg Capsule in Treatment of XXXX with @entity4 .

answer: @entity0


abstract: We operated 3 @entity0 with cervical @entity3 due to @entity5 ( @entity5 ). Specimens collected surgically were subjected to X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy (Raman) analysis and also histopathological examination. The @entity2 compounds deposited were @entity9 (CPPD) in Case 1, apatite in Case 2, and a double-layer structure with an outer CPPD layer and an inner @entity8 apatite layer in Case 3. Histopathologically, CPPD deposition in Case 1 could be distinguished from apatite deposition in Case 2 and 3 by @entity6 - @entity7 stain. Chondrocytes were observed in all 3 cases, suggesting the chondrocytes may have played a role in calcification in these three cases. To date, 62 cases of @entity5 (including the present cases) have been reported, and analysis of @entity2 compound has been performed for 29 of them. Of these 29, 15 were analyzed as @entity1 compounds, 9 as CPPD and 4 cases as mixed crystals like Case 3. However the analysis method and result about CPPD are no problem, the analysis result of @entity1 compounds depends on the using methods. @entity1 or undetectable compounds was identified by XRD as @entity4 (HAp), and by FTIR as @entity1 or undetectable compound. Analysis of @entity1 compounds should be condacted and identified by XRD, FTIR, and Raman. We propose two possible mechanisms for the formation of the double-layer structure in Case 3: one is formation of apatite first followed by deposition of CPPD outside, and the other is formation of CPPD first followed by conversion of CPPD in the central region to apatite. What the process of formation of the double-layer was in this cases remains unclear.

title: [Calcification of cervical ligamentum flavum--analysis of XXXX compounds and histopathological findings].

answer: @entity2


abstract: BACKGROUND: We compared the changes in cell morphology, total and differential cell counts between cerebrospinal fluid (CSF) samples analyzed within an hour of collection (fresh sample) and after the addition of autologous serum and storage for 24  h (stored sample) in 27 @entity0 with @entity2 . RESULTS: There was a positive linear correlation between total and differential cell counts in the fresh and the stored samples. Cell morphology was preserved in all stored samples, except for increased vacuolization of mononuclear cells and cleaved nuclei of some small mononuclear cells. In the stored CSF samples, the total nucleated cell count and monocyte percentage were decreased (P   =   0.01; P   =   0.03), while the lymphocyte percentage was increased (P   =   0.04). Mononuclear @entity1 diagnosed in 20 fresh samples was cytologically confirmed in 12 of the 20 stored samples. In the remaining eight stored samples, the number of total nucleated cells was within the normal range. Neutrophilic @entity1 was confirmed in all seven stored samples. The overall agreement rate between cytologic interpretation of the fresh and the stored CSF samples was 70  % (100  % for neutrophilic @entity1 and 60  % for mononuclear @entity1 ). CONCLUSIONS: Adding 11  % of autologous serum to CSF samples might allow delayed analysis with a good agreement rate for CSF cytological interpretation. Caution is nonetheless warranted, as animal age, anamnesis, and neurological presentation need to be considered when interpreting stored CSF without @entity1 .

title: Analysis of cerebrospinal fluid from XXXX with @entity2 after storage for 24  hours with autologous serum.

answer: @entity0


abstract: PURPOSE: Body mass index (BMI) is an inadequate measure of nutritional status in @entity0 and adolescents with @entity1 as it does not distinguish muscle from adipose tissue. However, arm anthropometry offers simple assessments of fat mass and lean body mass; especially valuable in low- and middle-income countries where the great majority of young @entity0 with @entity1 live and access to sophisticated expensive measures of body composition is markedly limited. METHODS: The nutritional status of 75 long-term survivors of @entity4 was assessed by arm anthropometry, in addition to BMI, in a cross-sectional cohort study. Normal ranges for @entity3 ( @entity3 , a surrogate for fat mass) and mid-upper arm circumference (MUAC, a surrogate for lean body mass) were between the 15th and 85th percentiles for age and sex. Overweight/ @entity2 was classified as a @entity3 >85th percentile and @entity5 as an MUAC   <15th percentile. Height normalized indices for @entity3 and MUAC were also calculated. RESULTS: Overweight/ @entity2 was identified in 1/3 of subjects by a BMI >25 and by @entity3 ; and 20% of the subjects had a @entity3 >95th percentile. Only two subjects were sarcopenic. None met the combined criteria for @entity2 . @entity3 and MUAC/height indices did not add sensitivity to identification of @entity5 or @entity2 . CONCLUSIONS: @entity3 is a useful measure of overweight/ @entity2 in this population, but MUAC does not identify a notable proportion with @entity5 . Further resolution may be provided by more sophisticated measures of body composition.

title: Anthropometry in Long-Term Survivors of XXXX in Childhood and Adolescence.

answer: @entity4


abstract: OBJECTIVE: To determine the extent and magnitude of unexpected @entity3 following @entity1 surgery with intraocular lens (IOL) implantation and to determine what characteristics were associated with the errors. DESIGN: In this nonconcurrent prospective study, preoperative, intraoperative and postoperative information was collected from the charts of the 523 consecutive @entity0 who underwent @entity1 extraction and polymethylmethacrylate IOL implantation performed by one of nine participating surgeons between Jan. 1 and @entity2 . 30, 1995, or the same dates in 1996. SETTING: University-affiliated eye care centre in Vancouver. OUTCOME MEASURE: Postoperative excess correction, calculated for each @entity0 by subtracting the actual postoperative spherical equivalent from the expected spherical equivalent. Eyes with an excess correction of more than 1.00 dioptre were considered "overcorrected." RESULTS: Univariate analysis showed that the formula used to calculate the lens power, axial length, year of surgery, A-constant/surgeon factor used and lens manufacturer were associated with overcorrection. In a logistic regression model, lens manufacturer was the only variable independently associated with overcorrection. CONCLUSIONS: Routine reporting and follow-up is necessary to identify this kind of "outbreak" and the associated factors. The current guidelines of the Health Protection Branch, Health Canada, for evaluation of IOLs that have changed manufacturers are not adequate to identify the kind of error that we detected.

title: An epidemiologic investigation of unexpected @entity3 following XXXX surgery.

answer: @entity1


abstract: OBJECTIVE: A phase II study was performed to assess the activity of @entity6 plus @entity7 ( @entity7 ) modulated by @entity9 , as second-line treatment in locally advanced or metastatic @entity5 pretreated with @entity3 -containing schedule. METHODS: @entity0 received weekly intravenous infusions of @entity6 40 mg/m, @entity7 500 mg/m, and @entity9 250 mg/m (3 weeks on, 1 week off). RESULTS: Twenty-three @entity0 affected with metastatic (16) or locally advanced (7) @entity5 were involved in this study. A total of 148 weeks of chemotherapy was delivered (median 2 courses each @entity0 ). Among 17 assessable @entity0 , no objective response was registered and 4 @entity0 had stable disease, whereas 13 had @entity1 progression. Median duration of stable disease was 14 weeks. Median @entity2 ( @entity8 ) was 11.6 weeks [95% confidence interval (CI), 7.6-5.6]. Kaplan-Meier estimated median overall survival (OS) was 17.1 week (95% CI, 4.0-30.1) and 3 months survival rate was 69.6%. Seven @entity0 experienced grade 3 to 4 @entity4 . The regimen was associated with 36% clinical benefit. CONCLUSIONS: The median @entity8 and median OS in this population with poor prognosis suggests some activity, however, only further investigations will be able to establish the clinical value of this combination.

title: XXXX , @entity7 , and @entity9 as second-line treatment for advanced pancreatic cancer.

answer: @entity6


abstract: OBJECTIVE: To use in vitro assays to evaluate the effects of a novel immunosuppressive agent, @entity6 , on biological functions (migration, phagocytosis, and production of reactive- @entity0 species [ROS]) of feline peripheral neutrophils and determine the cytotoxic effects of @entity6 on feline peripheral neutrophils. SAMPLE POPULATION: Peripheral neutrophils obtained from 8 healthy @entity1 . PROCEDURE: Peripheral neutrophils were isolated from blood samples obtained from the 8 @entity1 and exposed to the phosphorylated form of @entity6 ( @entity7 ). A fluorescence-based in vitro evaluation of migration was performed. Phagocytosis of microbes and production of ROS were evaluated by use of a 2-color flow cytometry system. Samples of whole blood obtained from the @entity1 were incubated with various concentrations of @entity7 , @entity3 -labeled @entity2 , and @entity5 . Cytotoxic effects were evaluated by use of @entity4 staining. RESULTS: Addition of @entity7 caused a slight non-significant decrease in phagocytosis and production of ROS by feline peripheral neutrophils. Migration activity of feline peripheral neutrophils was significantly increased by the addition of @entity7 . Addition of @entity7 at concentrations considered for clinical use did not increase the death rate of feline peripheral neutrophils. CONCLUSIONS AND CLINICAL RELEVANCE: @entity6 does not inhibit critical functions of feline peripheral neutrophils in vitro.

title: In vitro evaluation of the effect of a novel immunosuppressive agent, XXXX , on the function of feline neutrophils.

answer: @entity6


abstract: OBJECTIVE: To analyze the immediate results and the clinical evolution of a group of fertile age @entity0 with @entity1 , in whom percutaneous balloon mitral valvuloplasty was performed before or during pregnancy. @entity0 AND METHOD: Eighty-one @entity0 with @entity1 , submitted to balloon mitral vavuloplasty, were studied. They were divided into three groups, according to their desire of no further pregnancies (group A; n = 19), pregnancy during the follow-up (group B; n = 23) or valvuloplasty was performed during pregnancy (group C; n = 39). @entity0 from group B and C were controlled during pregnancy, childbirth and puerperium, and the newborns of @entity0 in group C were followed from birth to the age of 5 years. RESULTS: Mortality in the three groups was null and the incidence of miscarriage was 2 (8.6%) in group B and 3 (9.1%) in group C. Normal delivery was predominant in group B and delivery by caesarean was predominant in group B. Success was immediate in all the cases. The procedure was repeated in 3 @entity0 due to restenosis. The media valvar area rase from 0.93 to 2.05 cm2 in group A, from 1.28 to 2.04 cm2 in group B and from 0.84 to 2.14 cm2 in group C (intergroup p = NS). The functional class improved in the three groups of @entity0 . CONCLUSION: Percutaneous balloon mitral valvuloplasty is an effective, efficient method for the treatment of @entity1 during pregnancy, after organogenesis, or at any time in a @entity0 's life, as long as it is indicated according to clinical and echocardiographic evaluation criteria.

title: [The role of mitral valve balloon valvuloplasty in the treatment of rheumatic XXXX during pregnancy].

answer: @entity1


abstract: Australia has one of the highest rates of @entity3 in the world. Despite a high cure rate, many studies report relapse rates of between 5% and 20% with an associated mortality of 5-10%. The aim of this study was to review the patterns of relapse and outcome for @entity0 treated at Westmead Hospital, Sydney. Ninety-three eligible @entity0 were identified in a retrospective review of all @entity4 @entity0 referred to Westmead Hospital between 1980 and 1997. Relevant data were extracted from the treatment files and included contact with referring doctors and utilizing the Cancer Council Registry. Equal numbers of @entity0 were treated with radiotherapy alone or surgery (+/- adjuvant radiotherapy). The majority of @entity0 were male (78.5%) with T1N0 @entity1 (64.5%) of the lower lip. A minority (5.4%) had @entity2 at diagnosis. Following treatment, 31 (33.3%) @entity0 relapsed, 11 at the primary site, 18 at the regional nodes and two at both sites simultaneously. @entity0 treated with a combined approach (RTx/Sx) experienced a better outcome. Overall @entity1 -specific survival at 5 years was 85%. These findings highlight a disturbing relapse rate and mortality for a subgroup of @entity0 diagnosed with a more @entity4 . Treatment and follow up of these @entity0 should accordingly be more aggressive.

title: XXXX . Patterns of relapse and outcome: Reporting the Westmead Hospital experience, 1980-1997.

answer: @entity3


abstract: INTRODUCTION: Press Ganey (PG) scores are used by public entities to gauge the quality of @entity0 care from medical facilities in the United States. Academic health centers (AHCs) are charged with educating the new generation of doctors, but rely heavily on PG scores for their business operation. AHCs need to know what impact medical student involvement has on @entity0 care and their PG scores. PURPOSE: We sought to identify the impact students have on @entity1 ( @entity1 ) PG scores related to overall visit and the treating physician's performance. METHODS: This was a retrospective, observational cohort study of discharged @entity1 @entity0 who completed PG satisfaction surveys at one academic, and one community-based @entity1 . Outcomes were responses to questions about the overall visit assessment and doctor's care, measured on a five-point scale. We compared the distribution of responses for each question through proportions with 95% confidence intervals (CIs) stratified by medical student participation. For each question, we constructed a multivariable ordinal logistic regression model including medical student involvement and other independent variables known to affect PG scores. RESULTS: We analyzed 2,753 encounters, of which 259 (9.4%) had medical student involvement. For all questions, there were no appreciable differences in @entity0 responses when stratifying by medical student involvement. In regression models, medical student involvement was not associated with PG score for any outcome, including overall rating of care (odds ratio [OR] 1.10, 95% CI [0.90-1.34]) or likelihood of recommending our EDs (OR 1.07, 95% CI [0.86-1.32]). Findings were similar when each @entity1 was analyzed individually. CONCLUSION: We found that medical student involvement in @entity0 care did not adversely impact @entity1 PG scores in discharged @entity0 . Neither overall scores nor physician-specific scores were impacted. Results were similar at both the academic medical center and the community teaching hospital at our institution.

title: The Impact of Medical Student Participation in Emergency Medicine XXXX Care on Departmental Press Ganey Scores.

answer: @entity0


abstract: BACKGROUND: @entity0 with decompensated @entity3 ( @entity3 ) are frequently evaluated in @entity2 ( @entity2 ). The outcomes of such @entity0 after discharge to the outpatient setting from the @entity2 are not well known. Risk factors for @entity2 or subsequent hospital admission after @entity2 discharge for @entity3 also are not known. METHODS: Charts were reviewed from all 112 @entity0 discharged from the Parkland Memorial Hospital @entity2 with a primary diagnosis of @entity3 from October to December 1998. A composite end point ("failure of outpatient therapy") was prespecified to be a recurrent @entity2 visit for @entity3 , hospitalization for @entity3 , or @entity1 at 3 months after the index @entity2 discharge. RESULTS: Within 3 months of the index @entity2 visit, 61% of the study population met the composite end point. The median time to failure of outpatient therapy was 30 days. Univariate analysis of 27 clinical and demographic variables demonstrated the respiratory rate at presentation as the only predictor of failure of outpatient therapy (P =.02). Multivariate analysis of a model with 8 prespecified variables also demonstrated respiratory rate to be the only variable independently associated with an increased risk for the composite end point (odds ratio 1.6, 95% confidence interval 1.1-2.6, for each increase of 5 breaths/min). CONCLUSION: There is a high rate of failure of outpatient therapy (61%) in @entity0 discharged with a primary diagnosis of @entity3 from an urban county hospital @entity2 . Increased respiratory rate on presentation to the @entity2 may be associated with adverse outcomes after @entity2 discharge for @entity3 .

title: Outcomes after emergency department discharge with a primary diagnosis of XXXX .

answer: @entity3


abstract: PURPOSE: To assess the integrity of intrinsically photosensitive @entity3 cells (ipRGCs) using the pupillary light reflex in @entity1 @entity0 . METHODS: A cross-sectional study was conducted, including 76 eyes from 38 @entity0 with primary @entity2 and 36 eyes from 18 control subjects. The @entity0 were tested in the dark with light stimuli using the Ganzfeld system, and the pupil diameter was measured with the assistance of an eye tracker consisting of two infrared cameras fit to an eyeglass frame. To preferentially stimulate ipRGCs, we used a 1-second 470-nm flash with a luminance of 250 cd/m(2). To stimulate different retinal photoreceptors (cones and rods), we used a 1-second 630-nm flash with a luminance of 250 cd/m(2). Standard automated perimetry (SAP), matrix frequency-doubling technology (FDT), and high-definition optical coherence tomography (Cirrus HD-OCT) were also performed. The correlation between the ipRGC-mediated sustained response following the pupillary light reflex and the structural and functional changes in @entity1 @entity0 was analyzed using generalized estimating equation. RESULTS: An association was observed between the average retinal nerve fiber layer (RNFL) thickness, as measured by Cirrus HD-OCT, and the sustained pupillary response to the blue flash (P = 0.024). The severity of @entity1 , based on the mean deviation of SAP (Hodapp-Anderson-Parrish system), was also associated with the sustained response to the blue flash (P = 0.006). CONCLUSIONS: This study showed a correlation between the mean RNFL thickness and the pupillary light response. A decrease in the number of ipRGCs is potentially related to the reduced RNFL thickness.

title: A positive association between intrinsically photosensitive @entity3 cells and retinal nerve fiber layer thinning in XXXX .

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) is characterized by @entity1 and @entity9 . @entity6 mutations contribute to @entity1 . However, approximately half of the @entity0 with @entity1 have no mutation in @entity6 gene. METHODS: To investigate the incidence and effects of mutations of @entity6 and 25 candidate genes, @entity0 genes were screened using next-generation sequence analysis, and candidate mutations were confirmed using Sanger sequencing. The correlation between mutations and clinical manifestation was evaluated. RESULT: Thirty @entity0 , including 26 @entity0 (two families of five and two, 19 sporadic cases) with @entity1 , and 4 optic nerve @entity5 only control cases were evaluated in the present study. Six @entity6 mutations in 21 probands [28%; two in family cohorts (n = 5 and n = 2) and in 4 out of 19 @entity0 with @entity2 ] including four novel mutations were confirmed using Sanger sequencing. Moreover, four other sequence variants ( @entity8 , @entity7 , @entity11 , and @entity10 ) were also confirmed, including a potentially pathogenic novel @entity11 mutation. Kidney function and @entity4 were more severe in @entity0 with @entity6 mutations than in those without the mutation. Moreover, the @entity5 score was significantly higher in @entity0 with @entity6 gene mutations. Three out of five @entity0 with @entity6 mutations had @entity3 ( @entity3 ) diagnosed from kidney biopsies. CONCLUSION: The results of this study identify several new mutations of @entity6 , and sequence variants in four additional genes, including a novel potentially pathogenic mutation in @entity11 , which may play a role in the pathogenesis of @entity1 .

title: Association of @entity6 and Other Gene Mutations with the Clinical Manifestations of XXXX .

answer: @entity1


abstract: Culturing cells on microcarriers maximizes the ratio of surface area to culture medium volume. The aim of this study was to show microcarrier culture as a useful tool for improvement of steroidogenic activity in @entity0 Leydig cells. Freshly isolated cells were grown on Sephadex microcarriers, Cytodex 3, and gelatin beads (gelaspheres) that were uncoated, coated with collagen or coated with fibronectin. The cells were cultured in control or LH-supplemented medium. The effect of LH on @entity3 and @entity1 secretion was studied with appropriate radioimmunoassays. The activity of @entity4 dehydrogenases (3 beta-HSD, 17 beta-HSD) was evaluated histochemically. Leydig cells growing on microcarriers formed colonies. The strongest response to luteinizing hormone stimulation was observed on gelatin beads coated with fibronectin and collagen. In cells growing on a fibronectin layer, very strong activity of @entity5 and an increase in @entity2 hormone levels were observed. Basal and LH-stimulated @entity3 and @entity1 secretion were all much higher in the microcarrier than in the monolayer culture system. We conclude that Leydig cells maintain differentiated functions more efficiently on collagen- and fibronectin-coated gelasperes than on Sephadex microcarriers and that uncoated gelaspheres are less efficient than coated ones. Pure gelaspheres are unsuitable for improvement of the hormonal and enzymatic activity of Leydig cells.

title: XXXX Leydig cell culture on microcarriers.

answer: @entity0


abstract: The aim of this study was to determine the frequency of @entity2 descriptions from parents and guardians of @entity1 @entity0 which are useful for clinical classification of @entity1 . The data were obtained from 112 @entity0 using recurrent and spontaneous @entity1 as the selection criteria. The study was realized in two parts. In the part I the following aspects were studied: age of onset and the preictal, @entity3 . In the part II the specific kinds of @entity2 were classified by motor semiology, as @entity2 and nonconvulsive, and by using the International League Against @entity1 (ILAE,1981) scheme. The results showed that 42.9% @entity0 present @entity1 and 36.6% present lateralizing signs. Concerning the semiologic events were motor in 95.5%, neurovegetative in 56.3%, psychic in 32.1%, and neurosensorials in 4.5%. Finally, the ILAE schema classified the @entity2 as partial in 59.9%, as generalized in 27.2%, and as not classified in 12.5%. All findings demonstrate a good level of clinical semiology information from parents and guardians that allow us to classify 87.5% of the @entity2 , and identify auras and lateralized signs. Theses results permit us to conclud that if a standard protocol is used, the descriptions from parents and guardian of @entity1 @entity0 appears to be very reliable to clinical classification of @entity1 .

title: [Classification of XXXX in childhood obtained from @entity2 symptomatology descriptions of parents and guardians].

answer: @entity2


abstract: BACKGROUND/AIMS: There are few specific evaluation forms for evaluating the quality of life among @entity0 with chronic @entity1 . Our study aimed to determine the validity and reliability of the translated @entity0 Assessment of Constipation Quality of Life (PAC-QOL) questionnaire for the Turkish population because evidence of its reliability and validity is required to justify its use in other studies and clinical practice. MATERIALS AND METHODS: This study included 154 @entity0 with @entity1 who were treated at the Department of Gastroenterology, Dokuz Eyl  l University Hospital between January and June 2012. The translated PAC-QOL questionnaire was completed by @entity0 at the clinic and also at a 2-week follow-up to test its reliability. RESULTS: Cronbach's alpha coefficient (internal consistency) was 0.91 (good) for the translated PAC-QOL questionnaire. Time validity was evaluated using the intraclass correlation coefficient (ICC) method, and the ICC value for all questions was confirmed as 0.68 at the 2-week follow-up. The validity of the tool in the study group was evaluated using factor analysis, and the results were highly significant (Kaiser-Meyer-Olkin value: 0.857; Bartlett's test: p=0.001). Questions were categorized according to six factors based on the factor analysis, and these factors explained 65.1% of the total variation. For hypothesis verification of the tool, the correlation coefficient for @entity2 -QOL and @entity2 Symptoms (PAC-SYM) was r=0.577 (p<0.001), whereas the correlation coefficient for @entity2 -QOL and @entity1 severity score was r=0.457 (p<0.001). CONCLUSION: The @entity2 -QOL questionnaire was reliable, although not valid because of the limited sample group.

title: Validity and reliability of the XXXX assessment of @entity1 quality of life questionnaire for the Turkish population.

answer: @entity0


abstract: @entity6 ( @entity5 ) is a @entity2 -specific PET tracer. In future clinical applications of @entity2 imaging, such as early response monitoring or radiation therapy dose painting, accurate quantification of tracer uptake at the voxel level will be required. The aim of the present study was to assess the validity of parametric methods for the quantification of @entity4 -FAZA studies. METHODS: Dynamic 70-min @entity5 scans were obtained from 9 @entity3 @entity0 . Arterial blood samples, collected at 7 time points, were used for preprocessing an image-derived input function derived from volumes of interest (VOIs) defined within the ascending aorta. Time-activity curves derived from various @entity1 VOIs were fitted using nonlinear regression analysis (NLR) to a reversible 2-tissue-compartment model, providing volumes of distribution (VT) as an outcome measure. Next, parametric images were generated by use of both Logan graphic analysis with various linear regression start times and spectral analysis with multiple sets of basis functions. The previously defined @entity1 VOIs were projected onto these parametric images, and the resulting VT were compared with those obtained from NLR. In addition, the results were compared with @entity1 (SUVr), which are more easily obtainable. RESULTS: The highest correlations and correspondence with NLR-derived VT were found for Logan graphic analysis with a start time of 30 min after injection (R(2), 0.88; intraclass correlation coefficient [ICC], 0.93) and for spectral analysis-derived VT with a set of 30 basis functions with exponents ranging from 0.0175 to 1.9 (R(2), 0.79; ICC, 0.81). SUVr yielded similar correlations but showed significant bias at high VT (R(2), 0.85; ICC, 0.80). CONCLUSION: Both Logan graphic analysis and spectral analysis yielded VT that showed high correlations with nonlinear regression analysis-derived VT. SUVr showed bias at high VT.

title: Parametric Methods for Quantification of @entity5 Kinetics in @entity3 XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity6 ( @entity6 ) is a rare but important complication after supracondylar humerus @entity3 . @entity1 was first reported in 1948 and sporadically thereafter. @entity6 has been classified as type A ( @entity6 of the lateral ossification center) and type B ( @entity6 of the entire medial crista and a metaphyseal portion). In this article, we present 5 cases of @entity6 after supracondylar humerus @entity3 , discuss the importance of late clinical findings, and postulate a mechanism of @entity6 in nondisplaced @entity3 . Five cases of @entity6 after supracondylar humerus @entity3 were reviewed from the @entity0 's of Alabama database. Four of the 5 @entity0 were female. Four @entity0 sustained a Gartland @entity3 , and 1 @entity0 sustained a nondisplaced Gartland type I @entity3 . Age at time of injury ranged from 5 years to 10 years. All @entity0 had an asymptomatic clinical period after treatment and re-presented 6 months to 7 years later with @entity2 or @entity4 . All @entity0 were treated symptomatically. @entity6 of the trochlea has a late clinical presentation. The cause of this complication is interruption of the trochlea blood supply. In displaced @entity3 , the medial and/or lateral vessels are injured, leading to type A or type @entity1 . In nondisplaced @entity3 , the lateral vessels are interrupted by tamponade because of encased @entity3 @entity5 ; this presents as a type @entity1 . Both type A and type B deformities can be clinically significant. @entity6 of the trochlea should be considered in @entity0 with late presentation of @entity2 or @entity4 after treatment of supracondylar humerus @entity3 .

title: XXXX of Trochlea After Supracondylar Humerus Fractures in @entity0 .

answer: @entity6


abstract: BACKGROUND: There is a growing consensus that ovarian reserve is reduced after surgical excision of @entity1 . However, it remains to be fully clarified whether this damage precedes or follows surgery. In order to further elucidate this aspect, we evaluated ovarian responsiveness to hyperstimulation in @entity0 selected for IVF with unilateral unoperated @entity2 . The main aim of this study was to compare the number of developing follicles in the affected ovary with that in the contralateral intact gonad as a control. METHODS: @entity0 selected for IVF who were diagnosed with one or more @entity2 (diameter <4 cm) and who did not undergo previous ovarian surgery were retrospectively identified. We compared the number of follicles (diameter >=  11 mm) and the number of co-dominant follicles (diameter >15 mm) on the day of hCG administration in the affected and intact ovaries. RESULTS: Among the 84 @entity0 selected, the median interquartile range (IQR) number of follicles >=  11 mm in the affected and intact ovaries was 5 (3-7) and 5 (3-8), respectively (P= 0.36). The median (IQR) number of co-dominant follicles in the affected and intact ovaries was 3 (2-4) and 3 (2-5), respectively (P= 0.48). The number of co-dominant follicles was lower in the affected ovary in 36 cases (43%, 95% confidence interval: 32-53%). We also failed to identify any statistically significant difference between the two ovaries when evaluating data according to the number of cysts, their dimension, the dose of gonadotrophins used or the number of oocytes retrieved. CONCLUSIONS: In @entity0 selected for IVF, the presence of an @entity2 does not markedly affect responsiveness to hyperstimulation.

title: Unoperated XXXX and responsiveness to hyperstimulation.

answer: @entity1


abstract: BACKGROUND: Primary care-based memory clinics (PCMCs) have been established in several jurisdictions to improve the care for @entity0 with @entity1 and related @entity2 . We sought to identify key quality indicators (QIs), quality improvement mechanisms, and potential barriers and facilitators to the establishment of a quality assurance framework for PCMCs. METHODS: We employed a Delphi approach to obtain consensus from PCMC clinicians and specialist physicians on QIs and quality improvement mechanisms. Thirty-eight candidate QIs and 19 potential quality improvement mechanisms were presented to @entity0 in two rounds of electronic Delphi surveys. Written comments were collected and descriptively analyzed. RESULTS: The response rate for the first and second rounds were 21.3% (n = 179) and 12.8% (n = 88), respectively. The majority of respondents were physicians. Fourteen QIs remained after the consensus process. Ten quality improvement mechanisms were selected with those characterized by specialist integration, such as case discussions and mentorships, being ranked highly. Written comments revealed three major themes related to potential barriers and facilitators to quality assurance: 1) perceived importance, 2) collaboration and role clarity, and 3) implementation process. CONCLUSION: We successfully utilized a consultative process among primary and specialty providers to identify core QIs and quality improvement mechanisms for PCMCs. Identified quality improvement mechanisms highlight desire for multi-modal education. System integration and closer integration between PCMCs and specialists were emphasized as essential for the provision of high-quality @entity2 care in community settings.

title: Quality of XXXX Care in the Community: Identifying Key Quality Assurance Components.

answer: @entity2


abstract: @entity2 , which is often due to @entity1 or other conditions affecting bone strength, can lead to permanent disability, @entity0 , @entity5 , and/or @entity4 . Great effort has been directed toward developing noninvasive methods for evaluating proximal femoral strength ( @entity3 load), with the goal of assessing @entity3 risk. Previously, computed tomographic scan-based, linear finite element (FE) models were used to estimate proximal @entity6 loads ex vivo in two load configurations, one approximating joint loading during single-limb stance and the other simulating impact from a fall. Measured and computed @entity3 loads were correlated (stance, r=0.867; fall, r=0.949). However, precision for the stance configuration was insufficient to identify subjects with below average @entity3 loads reliably. The present study examined whether, for this configuration, nonlinear FE models could be used to identify these subjects. These models were found to predict @entity3 load within +/-2.0 kN (r=0.962). This level of precision is sufficient to identify 97.5% of femora with @entity3 loads 1.3 standard deviations below the mean as having below average @entity3 loads. Accordingly, 20% of subjects with below average @entity3 loads, i.e. those with the lowest @entity3 loads and likely to be at greatest risk of @entity3 , would be correctly identified with at least 97.5% reliability. This FE modeling method will be a powerful tool for studies of @entity2 .

title: Improved prediction of proximal XXXX load using nonlinear finite element models.

answer: @entity6


abstract: BACKGROUND: It has recently been shown that t (12;21) (p13;q 22) is the most common molecular @entity2 in childhood @entity3 ( @entity3 ). We have analyzed this translocation in an attempt to evaluate its incidence and to monitor @entity1 ( @entity1 ) with t (12; 21) rearrangement by detection of @entity6 - @entity5 transcript in @entity0 with @entity3 . PROCEDURE: All cryopreserved bone marrow samples were analyzed using a nested reverse transcription-polymerase chain reaction (RT-PCR) method. @entity6 - @entity5 transcripts were searched for in 34 @entity3 @entity0 , including six in relapse consecutively diagnosed at our institution between 1991 and 1997. RESULTS: @entity6 - @entity5 transcripts were found in five (19%) of 27 @entity0 with B precursor @entity3 . The @entity0 with @entity4 , chromosome 11q23 rearrangement and @entity3 @entity0 did not express @entity6 - @entity5 transcripts. Moreover, @entity1 in five @entity0 with @entity6 - @entity5 transcripts were analyzed in serial samples. Although @entity6 - @entity5 transcripts disappeared soon after the beginning of chemotherapy in three of the five @entity0 , one @entity0 continued to express them for up to 21 months without recurrence and remained in continuous complete remission for seven years after the cessation of chemotherapy. The remaining @entity0 was admitted to our hospital after the second relapse but died following a failure to induce complete remission. CONCLUSION: For most @entity0 , the presence of @entity6 - @entity5 transcripts suggests excellent chemosensitivity and a favorable prognosis, but some @entity0 with these transcripts have a different outcome. The present study suggests the possibility that a persistence of @entity1 is not necessarily related to a relapse of @entity3 with @entity6 - @entity5 fusion. The prognostic significance of @entity6 - @entity5 transcript remains controversial. Further studies are needed to evaluate the relation between the @entity6 - @entity5 transcript and prognosis.

title: Persistence of XXXX - @entity5 transcript in @entity3 in long-term remission.

answer: @entity6


abstract: The objective was to evaluate mid-term results after @entity2 ( @entity2 ) with special focus on the bias due to an application to social insurance for pension based on @entity1 . The study group consisted of 42 @entity0 (28 male, 14 female). @entity2 was performed in 1993 or 1994 for impingement stage II. The mean age was 49.5 years. Thirty-nine @entity0 (93%) were evaluated by an independent observer for an average follow-up of 3.5 years (range 1.5-5). @entity0 satisfaction with the outcome was assessed by a visual analog scale graded from 0 (extremely dissatisfied) to 10 (extremely satisfied). The functional result was assessed using the Constant score. At follow-up the mean VAS value was 6.4 +/- 3.4. The Constant score improved from 49.6 +/- 18.5 to 84.8 +/- 14.3. The subgroup of @entity0 having applied to social insurance for pension had significantly worse results compared with the remaining @entity0 : VAS: 4.9 +/- 3.1 vs. 7.5 +/- 3.1; Constant-Score: 76.1 +/- 12.7 vs. 88.3 +/- 13.5. The fact that @entity0 try to get benefit from social insurance based on @entity1 significantly biased the outcome after @entity2 .

title: [Intermediate-term results after XXXX with special reference to ongoing disability claims].

answer: @entity2


abstract: Recently, a novel form of MSI has been described that occurs only at tetranucleotide repeat markers. This has been termed elevated microsatellite instability at selected tetranucleotide repeats (EMAST). EMAST has been related to alterations of the @entity2 gene, and to the nature of the repeat sequence. We initially tested whether loss of heterozygosity (LOH) at the @entity2 and the patched (ptch) genes was related to EMAST in a series of 61 @entity3 ( @entity3 ) @entity0 . We then analysed a series of 57 primary @entity1 for the presence of EMAST, testing whether this was related to mutation or expression of the @entity2 gene. In both @entity3 and @entity1 we found a high prevalence of EMAST (75.4 and 43.9%). In @entity3 the prevalence of EMAST was higher in @entity0 that had either @entity2 or ptch LOH, although the difference was not statistically significant. There was a significant association of extensive EMAST (three or more loci) with mutations in @entity2 among the @entity1 , but no indication of elevated EMAST in @entity0 with abnormal @entity2 staining without mutation. The association of EMAST with @entity2 mutation was confined to non-invasive disease. Hence, EMAST likely reflects a particular pattern of somatic events that are interactive with @entity2 mutation, particularly common in @entity3 and limited to non-invasive disease in @entity1 .

title: Microsatellite instability at tetranucleotide repeats in skin and XXXX .

answer: @entity1


abstract: INTRODUCTION: Stereotactic body radiotherapy (SBRT) is rapidly gaining favor as a new treatment modality for malignant @entity2 . Most of the studies have recruited @entity0 with disseminated disease originating from the liver. This study focuses on disease limited to the liver. AIM: To perform a retrospective analysis of all @entity0 with @entity2 treated by robotic stereotactic body radiation therapy in a single center. MATERIAL AND METHODS: The study included 13 @entity0 with 22 lesions. The inclusion criteria were: @entity0 with 1-4 inoperable @entity3 and absence of any @entity5 . All but 3 @entity0 received 3 fractions delivered by the Cyberknife system of a total of 45 grey (Gy). The other 3 @entity0 received 30 Gy. RESULTS: The median follow-up time was 10.8 months (range: 7-16). The median dose was 41.5 Gy (range: 30-45). One lesion regressed (8%). In 5 @entity0 , the disease was locally stabilized (38%), and in 7 other @entity0 progression occurred (54%). Twelve @entity0 (92%) are still alive, and 1 @entity0 (8%) died. In 1 @entity0 a new @entity1 ( @entity4 ) was diagnosed. CONCLUSIONS: The SBRT is well tolerated and effective for local control of most @entity2 . It appears that SBRT is best suited for those @entity0 in whom systemic recurrence can be controlled by chemotherapy. Further studies are mandatory to elucidate these effects on @entity1 of varying histology and to elaborate upon criteria used to select @entity0 who can benefit most from this treatment.

title: Robotic stereotactic body radiation therapy for liver-limited XXXX .

answer: @entity1


abstract: BACKGROUND: @entity6 is characterized by the accumulation of lymphocytes as a consequence of increased recruitment from the blood and retention within the tissue at sites of @entity2 . @entity8 ( @entity8 ) mRNA has been detected in both inflamed and normal liver tissues and is strongly upregulated in the injured liver tissues in a @entity0 model. The aim of this study was to investigate the effect of @entity7 on @entity8 mRNA of liver tissues in @entity0 with immunological @entity1 . METHODS: The @entity0 model of immunological @entity1 was induced by Bacillus Calmette Guerin and Lipoposaccharide. The @entity0 with immunological @entity1 were randomly assigned to the model group, the @entity7 group and the @entity5 group. The three groups were continuously given agents for seven days and @entity8 mRNA of liver tissue was determined and contrasted with the control group treated by normal saline. Reverse transcription-polymerase chain reaction was used to assay @entity8 mRNA levels in liver tissues. RESULTS: The expressions of @entity8 mRNA were significantly higher in the model group and the @entity5 group than in the control group and the @entity7 group (P < 0.05), indicating the @entity0 in the model group and the @entity5 group were @entity4 . There was no statistical difference in the expressions of @entity8 mRNA between the control group and the @entity7 group. Similarly, no statistical difference in the expressions of @entity8 mRNA between the model group and the @entity5 group was detected (P > 0.05). CONCLUSION: @entity7 effectively reduces the infiltration of lymphocytes into liver tissues and alleviates the @entity3 by decreasing @entity8 mRNA in liver tissues in @entity0 with immunological @entity1 .

title: Effects of @entity7 on chemokines of liver tissues in @entity0 with immunological XXXX .

answer: @entity1


abstract: OBJECTIVE: To determine the degree of compliance with sunscreen use among renal transplant recipients before and after transplantation and to determine risk factors associated with @entity1 . DESIGN: Single-observer study with structured interview using a standardized questionnaire. Medical records and histology reports were examined for details of prior @entity3 . Cox proportional hazards regression was used for analysis of risk factors for developing @entity3 after transplantation. SETTING: @entity0 attending Beaumont Hospital, the national renal transplantation center in Dublin, Ireland. @entity0 : The study population comprised 270 @entity0 (182 male and 88 female). MAIN OUTCOME MEASURES: @entity0 ' use of sunscreens before and after transplantation relative to known @entity3 risk factors and subsequent @entity1 . RESULTS: Prior to transplantation, 68.5% of @entity0 never applied sunscreen on a sunny day compared with 25.9% after transplantation. @entity0 50 years or younger were more likely to always apply sunscreen both before and after transplantation (P = .01), as were female @entity0 prior to transplantation (P = .02). Those @entity0 who participated in an outdoor recreation were more likely to subsequently develop @entity3 (P = .04), as were those older than 50 years (P<.001) and those with a history of 2 or more @entity2 (P = .03). CONCLUSIONS: Transplant recipients are poorly compliant with the use of sunscreens both before and after transplantation. Compliance is poorest in those groups at higher risk of @entity3 .

title: Sunscreen use before and after transplantation and assessment of risk factors associated with XXXX development in renal transplant recipients.

answer: @entity3


abstract: In this phase I/II clinical trial the antitumor activity of high-dose @entity5 when administered in combination with @entity8 was assessed and the @entity1 profile of this combination characterized. All 25 @entity0 enrolled in this study were required to have @entity4 -independent @entity3 and to maintain @entity4 ablation during treatment. @entity8 was given by continuous infusion over 5 days. Doses were increased from 0.9 mg/m2/day to 1.5 mg/m2/day in successive cohorts of at least 3 @entity0 , with no further escalation even in the absence of dose-limiting @entity1 . Intra- @entity0 dose escalation was permitted. @entity5 was administered at a dose of 200 mg/kg on day 1, then 120 mg/kg/day on day 2. Standard response criteria were utilized to assess antitumor activity and CTC @entity1 criteria were used. Quality of life (QOL) @entity2 assessments were evaluated at each visit to the clinic. Most @entity0 tolerated the highest dose of @entity8 at 1.5 mg/m2/day by continuous infusion over 5 days with 200 mg/kg/day of @entity5 on day 1 and day 2. One @entity0 had a greater than 50% decline in prostate-specific antigen that lasted for 170 days. Two @entity0 received dose reductions because of @entity1 . The most common serious @entity1 included @entity7 , and @entity6 . Reversible neurosensory, neuromotor, neurocortical and @entity1 were reported. Six of the 25 @entity0 enrolled in the study (24%) experienced reversible @entity1 of at least grade III. No statistically significant differences between precycle assessment of QOL and subsequent cycles were observed. It is concluded that @entity8 at 1.5 mg/m2/day continuous i.v. infusion combined with @entity5 200 mg/kg/day on day 1 and day 2 is inactive, and not without @entity1 in the treatment of advanced metastatic @entity4 -independent @entity3 .

title: A phase I/II study of high-dose @entity5 in combination with @entity8 in @entity0 with XXXX -independent @entity3 .

answer: @entity4


abstract: OBJECTIVES: The two goals of the present study were to (1) determine the ability of commonly used aerodynamic voice measures to capture change as a function of known interventions and (2) determine if certain aerodynamic measures demonstrate better responsiveness to change in specific disorder types than others. STUDY DESIGN: This is a retrospective, longitudinal, single-blinded, cross-sectional study. METHODS: @entity0 (n = 70) with a single @entity2 diagnosis of benign vocal fold lesions (lesions), unilateral vocal fold paralysis (UVFP), primary muscle tension @entity3 (MTD-1), or vocal fold @entity1 ( @entity1 ) underwent baseline testing, a single intervention (phonosurgery or voice therapy), and follow-up testing. Common aerodynamic measurements were completed in repeated syllables and an all-voiced sentence. RESULTS: Statistically significant improvements were observed for two outcome measures, average airflow in syllables, and average airflow in the all-voiced sentence. @entity0 with lesions, UVFP, and MTD-1 improved in average airflow in the all-voiced sentence. @entity0 with UVFP also improved in airflow in syllables. CONCLUSIONS: Average airflow in the all-voiced sentence changed as a function of treatment for the lesion, MTD-1, and UVFP groups, demonstrating a disorder-specific pattern. Laryngeal airway resistance, and estimates of average subglottal pressure did not show significant change. Average airflow in the all-voiced sentence measurements is recommended as a routine voice measure, and further investigation of other aerodynamic measures' sensitivity to change is warranted.

title: Aerodynamic Outcomes of Four Common XXXX : Moving Toward Disorder-Specific Assessment.

answer: @entity2


abstract: BACKGROUND: An uncontrolled pilot study demonstrated that daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor ( @entity3 ), might be effective for the treatment of active @entity1 . METHODS: A randomised, double blind, placebo controlled trial was conducted to evaluate the efficacy of daclizumab induction therapy in @entity0 with active @entity1 . A total of 159 @entity0 with moderate @entity1 were randomised to receive induction therapy with daclizumab 1 mg/kg intravenously at weeks 0 and 4, or 2 mg/kg intravenously at weeks 0, 2, 4, and 6, or placebo. The primary end point was induction of remission at week 8. Remission was defined as a Mayo score of 0 on both @entity2 and a score of 0 or 1 on stool frequency and physician's global assessment components. Response was defined as a decrease from baseline in the Mayo score of at least 3 points. RESULTS: Two per cent of @entity0 receiving daclizumab 1 mg/kg (p = 0.11 v placebo) and 7% of @entity0 receiving 2 mg/kg (p = 0.73) were in remission at week 8, compared with 10% of those who received placebo. Response occurred at week 8 in 25% of @entity0 receiving daclizumab 1 mg/kg (p = 0.04) and in 33% of @entity0 receiving 2 mg/kg (p = 0.30) versus 44% of those receiving placebo. Daclizumab was well tolerated. The most frequently reported adverse events in daclizumab treated @entity0 compared with placebo treated @entity0 were @entity4 (14.6%) and pyrexia (10.7%). CONCLUSION: @entity0 with moderate @entity1 who are treated with daclizumab are not more likely to be in remission or response at eight weeks than @entity0 treated with placebo.

title: Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor ( XXXX ), for the treatment of moderately to severely active @entity1 : a randomised, double blind, placebo controlled, dose ranging trial.

answer: @entity3


abstract: BACKGROUND: @entity1 and @entity5 are often observed in biopsy specimens from the duodenal bulb of Heliobacter @entity6 positive @entity0 with @entity12 ( @entity12 ). AIMS: We set out to investigate the prevalence of these lesions and their associations with other gastric and duodenal histopathological lesions. @entity0 : A total of 1255 consecutive @entity0 who underwent upper gastrointestinal endoscopy were recruited into the present study. METHODS: Two biopsy specimens were obtained from each of the following sites: duodenal bulb, gastric antrum, gastric body, and distal to the superior duodenal angle. These specimens were stained with @entity7 - @entity8 , alcian blue periodic acid Schiff (pH 2.5) and modified Giemsa (Heliobacter @entity6 infection was determined only by histology). RESULTS: The mean age of the study population was 57 years, and male:female ratio 1:1.6. Overall, 235 (19%) had @entity5 in the duodenal bulb mucosa, and @entity6 organisms could be found in 17 (1%). In univariate analyses, @entity5 and/or chronic @entity1 positively associated with male sex (p = 0.046), Heliobacter @entity6 -positive chronic @entity10 (p = 0.033), villous @entity4 , i.e., @entity2 (p < 0.001), duodenal ulcer (p < 0.001), and @entity3 and @entity9 in endoscopy (p < 0.001), but not with age (p = 0.7) nor use of nonsteroidal anti-inflammatory drugs (p = 0.055). Multivariate analysis revealed that independent risk factors for @entity5 and chronic @entity1 in duodenal bulb were duodenal Heliobacter @entity6 infection (odds ratio 1.6, 95% confidence interval CI 1.1-2.1), and villous atrophy of the distal duodenal mucosa (odds ratio 12.7, 95% CI 4.4-36.5), while chronic @entity11 was protective against them (odds ratio 0.5, 95% CI 0.3-0.8). CONCLUSIONS: In addition to Heliobacter @entity6 infection, duodenal @entity5 and chronic @entity1 may result from predisposition to toxic dietary components in gluten-sensitive subjects.

title: @entity5 and chronic XXXX at the duodenal bulb mucosa.

answer: @entity1


abstract: STUDY DESIGN: This investigation compared the gait of revision and primary @entity1 @entity0 about to undergo surgical reconstruction with that of a group of able-bodied controls. OBJECTIVES: The hypothesis of the study was that both @entity0 groups would have significantly compromised gait, spine motion, and gait endurance compared with the able-bodied group. SUMMARY OF BACKGROUND DATA: There is a population of adults with degenerative changes superimposed on @entity2 who present for reconstructive spinal surgery (primary @entity0 ). There is another group of adults who have already had @entity1 surgery and present for revision surgery (revision @entity0 ). METHODS: Twenty-seven @entity0 were recruited (8 primary, 13 revision, 6 able-bodied controls). A typical gait analysis was performed. Walking endurance was estimated from a submaximal graded treadmill exercise test. Three motion variables describing the orientation of the shoulders with respect to the pelvis in the three principal planes of the body were determined. Also, gait speed, stride length, cadence, and step width were calculated. The variable for the endurance test was the length of time walked on the treadmill. RESULTS: Results for the revision group indicated a slower walking speed, greater sagittal plane trunk flexion, reduced range of motion in the coronal and transverse planes, and poorer endurance relative to age-matched controls. The primary group demonstrated a slower walking speed relative to age-matched controls. The revision group had poorer endurance scores relative to the primary group. CONCLUSION: This investigation is an objective report describing the compromised gait and walking endurance of adult @entity0 with @entity1 before spinal fusion surgery. Results supported subjective observations regarding the preoperative gait of these @entity0 and presented results difficult to observe in a clinical setting. The techniques appear useful in providing objective information regarding the gait abilities of these @entity0 .

title: Preoperative gait comparisons between adults undergoing long XXXX fusion surgery (thoracic to L4, L5, or sacrum) and controls.

answer: @entity1


abstract: Lipids are an important nutritional component of the avian egg. A review of the literature was completed to determine the @entity6 compositions in egg yolk from some avian species. Additionally, the nutritional influence of lipid and lipoprotein content on the plasma of male @entity0 during 30-day feeding was discussed. The @entity9 eggs had the highest @entity8 and the lowest @entity1 content in relation to other avian species. @entity9 had a higher proportion of 18:3n-3 (p   <   0.01) compared with other species. @entity7 yolk numerically contained much higher levels of 22:6n-3 than those found in @entity2 , quails and geese, but the amount of 22:6n-3 in @entity9 egg was lower by comparison with other species (p   <   0.01). After the storage of eggs at the room temperature, there was a notable loss of @entity3 (vitE) in the yolks of all species and this decrease was marginal (p   <   0.01) in @entity9 compared with other species. There were significant (p   <   0.05) increases in plasma low-density lipoprotein (LDL) level in all male subjects. Plasma high-density lipoprotein (HDL) level decreased (p   <   0.05) only in @entity0 who were fed @entity7 or @entity9 eggs daily. Consumption of different species' eggs had no influence on the total male plasma @entity1 and @entity5 levels. LDL-C:HDL-C ratio increased (p   <   0.05) after goose and @entity2 egg consumption. Consumption of one egg/month by healthy @entity0 subjects had no effect on serum total @entity1 and @entity5 . The LDL-C:HDL-C ratio (which is a strong predictor of @entity4 risk) increased, although non-significantly, by consuming @entity7 , quail and @entity9 eggs.

title: Egg yolk XXXX profile of avian species--influence on @entity0 nutrition.

answer: @entity6


abstract: BACKGROUND: @entity0 studies suggest @entity5 smoking is a risk factor for @entity2 and @entity3 , including @entity4 ( @entity4 ). However, experimental data linking @entity5 smoke exposures to underlying mediators of @entity3 , including @entity6 factor (IGF) signaling in @entity4 are lacking. OBJECTIVE: This study tests the hypothesis that cigarette smoke (CS) exposures can impair brain insulin/IGF signaling and alter expression of @entity4 -associated proteins. METHODS: Adult male A/J @entity1 were exposed to air for 8 weeks (A8), CS for 4 or 8 weeks (CS4, CS8), or CS8 followed by 2 weeks recovery (CS8+R). Gene expression was measured by qRT-PCR analysis and proteins were measured by multiplex bead-based or direct binding duplex ELISAs. RESULTS: CS exposure effects on insulin/IGF and insulin receptor substrate (IRS) proteins and phosphorylated proteins were striking compared with the mRNA. The main consequences of CS4 or CS8 exposures were to significantly reduce insulin R, IGF-1R, IRS-1, and @entity7 phosphorylated insulin R and IGF-1R proteins. Paradoxically, these effects were even greater in the CS8+R group. In addition, relative levels of S312-IRS-1, which inhibits downstream signaling, were increased in the CS4, CS8, and CS8+R groups. Correspondingly, CS and CS8+R exposures inhibited expression of proteins and phosphoproteins required for signaling through Akt, PRAS40, and/or p70S6K, increased AbPP-Ab, and reduced ASPH protein, which is a target of insulin/IGF-1 signaling. CONCLUSION: Secondhand CS exposures caused molecular and biochemical abnormalities in brain that overlap with the findings in @entity4 , and many of these effects were sustained or worsened despite short-term CS withdrawal.

title: XXXX Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration.

answer: @entity5


abstract: UNASSIGNED: The mechanism underlying the development of @entity0 @entity2 is poorly understood. The liver kinase protein, @entity5 , is hypothesized to play a pivotal role in @entity1 cell proliferation and invasion capacity through regulation of @entity3 and @entity4 / @entity4 expression. Previous studies suggest @entity5 may, in turn, be regulated by microRNA-17. Here, we examined the role of @entity6 in the expression of @entity5 and the downstream effects on proliferation and invasion capacity of normal @entity2 cells (OCCs) and ovarian stem cells. In this study, both the mRNA and protein expression levels of @entity5 , @entity3 , and @entity4 decreased in OCCs following transfection with a @entity6 expression plasmid. @entity6 expression affected cell cycle regulation and stimulated the proliferation and invasion capacity of OCCs in vitro. ChIP assays indicated that the binding efficiency of @entity3 to the @entity4 / @entity4 gene promoter was much lower in @entity6 transfected OCCs than in OCCs transfected with a mutated @entity6 . Co-immunoprecipitation and western blotting showed significantly lower levels of @entity3 and @entity3 Ser15-pho in the @entity6 transfected OCCs as compared to the mutant @entity6 transfected OCCs. Xenograft experiments confirmed that suppression of @entity1 growth in vivo occurred in the absence of functional @entity6 . These findings suggest that mature @entity6 expression may have an important role in the pathogenesis of @entity0 @entity2 through its interference with the @entity5 - @entity3 - @entity4 / @entity4 pathway expression by epigenetic modification. These findings are of potential importance in the identification of novel therapeutic targets in @entity0 @entity2 .

title: MicroRNA-17 promotes normal XXXX cells to @entity1 stem cells development via suppression of the @entity5 - @entity3 - @entity4 / @entity4 pathway.

answer: @entity2


abstract: Vocal @entity5 are increasingly recognized in @entity0 with @entity6 ( @entity6 ). We describe a @entity0 with limb-onset @entity6 who developed @entity11 . A 74-year-old Japanese male consulted our clinic with a 6-month history of @entity3 in both arms. His family history was unremarkable. There were @entity10 and mild @entity1 and both arms. In the legs, muscle strength was almost normal but widespread @entity10 were present. All tendon reflexes were hypoactive and pathological reflexes were absent. Thereafter, he developed @entity3 and showed increased eating time. Babinski sign was positive bilaterally at this stage. The forced vital capacity dropped from 90% at the initial evaluation to 62% of the predicted value 14 months later. Two years after disease onset, the @entity0 developed @entity8 with hoarseness and had difficulty clearing his throat of phlegm. Laryngoscopy demonstrated severe @entity11 on both sides, particularly in the abductor muscles possibly leading to obstruction. Tracheotomy was performed because of the risk that the @entity0 could @entity9 to @entity2 . A review of the literature suggests that severe @entity4 could be a prelude to @entity7 in @entity6 . Follow up by laryngoscopic examination is necessary.

title: [A case of XXXX with bilateral @entity11 necessitating tracheotomy].

answer: @entity6


abstract: BACKGROUND AND PURPOSE: We aimed to generate rigorous graphical and statistical reference data based on volumetric measurements for assessing the relative severity of @entity2 ( @entity2 ) in @entity0 with @entity3 . METHODS: We prospectively mapped @entity2 from 2699 @entity0 with first-ever @entity6 (mean age=66.8  13.0 years) enrolled consecutively from 11 nationwide @entity3 centers, from @entity0 (fluid-attenuated-inversion-recovery) MRIs onto a standard brain template set. Using multivariable analyses, we assessed the impact of major (age/ @entity4 ) and minor risk factors on WMH variability. RESULTS: We have produced a large reference data library showing the location and quantity of @entity2 as topographical frequency-volume maps. This easy-to-use graphical reference data set allows the quantitative estimation of the severity of WMH as a percentile rank score. For all @entity0 (median age=69 years), multivariable analysis showed that age, @entity4 , @entity8 , and @entity9 were independently associated with increasing WMH (0-9.4%, median=0.6%, of the measured brain volume). For younger ( <=69) @entity4 (n=819), age and @entity9 were positively associated with WMH. For older (>= 70) @entity4 (n=944), age and @entity5 had positive relationships with WMH, whereas @entity1 , @entity7 , and @entity8 had negative relationships with WMH. For younger nonhypertensives (n=578), age and @entity1 were positively related to WMH. For older nonhypertensives (n=328), only age was positively associated with WMH. CONCLUSIONS: We have generated a novel graphical WMH grading (Kim statistical WMH scoring) system, correlated to risk factors and adjusted for age/ @entity4 . Further studies are required to confirm whether the combined data set allows grading of WMH burden in individual @entity0 and a tailored @entity0 -specific interpretation in @entity6 -related clinical practice.

title: Grading and interpretation of XXXX using statistical maps.

answer: @entity2


abstract: Prognostic factors and treatment outcome of 48 @entity0 with Stage I (29) or II (19) @entity8 of the head and neck were analyzed retrospectively. There were 26 males and 22 females, aged from 15 to 89 years old, with an average age of 57. The @entity1 was located in @entity9 in 25 @entity0 , the nasal cavity and paranasal sinuses in 13, cervical lymph nodes in 8, and others in 2. Histologically, 2 had @entity8 , 42 had intermediate grade disease, and 1 had high grade disease. The @entity0 were treated with radiation alone (5 @entity0 ), chemotherapy according to a @entity6 , @entity5 , @entity7 , @entity4 - (CHOP) regimen (8 @entity0 ), or a combination of both treatments (35 @entity0 ). In univariate analyses, an unfavorable prognosis was associated with age > or = 60, Stage I disease, and extralymphatic lesion. Multivariate analysis showed that an extralymphatic lesion was a significant independent risk factor for @entity3 (p = 0.0093). The overall five-year survival rate was 73.5%. Differences in the treatment was not reflected in the outcome. Our results suggest that a combination of chemotherapy (CHOP) and radiation is an appropriate treatment for lymphatic stage I and II @entity8 of the head and neck. However, more intensive therapy is necessary for @entity0 with extralymphatic @entity2 .

title: [Statistical analysis of localized XXXX of the head and neck--multivariate analysis of prognostic factors and evaluation of therapeutic modalities].

answer: @entity8


abstract: We used very sensitive and specific monoclonal-antibody sandwich assays for @entity0 chorionic gonadotropin ( @entity1 ) and @entity0 luteinizing hormone (hLH) to measure both hormones in serum samples from normal @entity0 and @entity0 . When single serum samples from 92 @entity0 were studied, 73 percent had detectable @entity1 . In normal @entity0 , the amount of detectable @entity1 averaged 8.9 pg per milliliter, with a range of less than 3.0 to 160 pg per milliliter (biologic potency = 13,450 IU per milligram). In postmenopausal @entity0 the @entity1 level averaged 111 pg per milliliter and ranged from 32 to 510. In @entity0 of reproductive age the @entity1 level varied with the menstrual cycle. @entity2 administered to 10 normal @entity0 increased both @entity1 and hLH. When daily serum samples were studied throughout a normal menstrual cycle, @entity1 concentrations paralleled those of hLH; follicular-phase concentrations were higher than those of the luteal phase, and there was a midcycle ovulatory peak of @entity1 coincident with the hLH peak. When @entity1 was measured every 10 minutes for six hours in eight postmenopausal @entity0 , distinct pulses were detected in parallel with those of hLH: hLH pulsed at a mean (+/- SEM) frequency of 0.56 +/- 0.08 pulses per hour; @entity1 pulsed at 0.54 +/- 0.07 pulses per hour. The mean pulse durations were 89 +/- 22 and 56 +/- 20 minutes for @entity1 , respectively. We conclude that @entity1 is produced in a pulsatile fashion, probably by the pituitary, in all normal adults.

title: Pulsatile secretion of XXXX chorionic gonadotropin in normal adults.

answer: @entity0


abstract: The KS 300 is a multifunctional software image analysis system using an object-oriented programming environment. The possibility of its application for the inner ear was studied by using specimens from @entity0 and squirrel monkeys, immunostained for the brain-derived @entity1 -binding protein, @entity2 protein. Grey images were used for measurements. The cell borders were outlined by hand, using a digitizer. The absolute grey values of the pixels changed when the brightness of the images or other conditions changed. By contrast, the relative grey values, i.e. the absolute grey values correlated to the mean grey values of the histoimage, remained constant. By utilizing these relative grey values, it was possible to compare cells both between different specimens and between different areas within the same specimen. The different grey values of @entity3 cells stained for @entity2 protein are objective quantitative measurements and are believed to reflect differences in their function. In some regions of both @entity0 and squirrel monkey specimens, relatively intensely stained cells predominated, whereas in other regions, relatively weakly stained cells were mainly observed. Thus, our image analysis system using the relative grey values has proved suitable for quantitative analysis of immunostained specimens in order to compare them and to assess cell function.

title: Image analysis of the XXXX inner ear.

answer: @entity0


abstract: OBJECTIVE: @entity6 is required for @entity4 and robust autoantibody development in the @entity7 model of @entity0 @entity3 . The objective of this study was to evaluate the immune response and to study the splenic B and T cell populations in @entity1 ( @entity1 ) and @entity6 -/- @entity0 following @entity7 injection in order to develop an understanding of why absence of @entity6 is protective in @entity7 -induced @entity3 . METHODS: Immunization responses to NP-Ficoll and NP-ovalbumin were assessed in @entity1 and @entity6 -/- @entity0 . In  vitro IgM and IgG responses to R848 were measured by ELISA. Serum IgM anti-dsDNA and @entity2 were also measured by ELISA. B and T cell populations 2 weeks and 6 months following @entity7 injection were measured by flow cytometry in @entity1 and @entity6 -/- @entity0 . RESULTS: @entity6 -/- @entity0 generate equivalent IgG responses to NP-Ficoll and NP-ova antigens when compared to @entity1 @entity0 . Additionally, they secrete IgM and IgG in response to @entity5 activation. @entity7 injected @entity1 and @entity6 -/- @entity0 generate robust IgM anti-dsDNA responses. @entity6 -/- @entity0 have a significant reduction in marginal zone B cell populations compared to @entity1 6 months after @entity7 exposure whereas T cell responses are intact in these @entity0 . CONCLUSIONS: @entity6 -/- @entity0 have intact immune responses but do not develop an expanded marginal zone B cell population in response to @entity7 -induced @entity3 . This may be one explanation for reduced IgG autoantibody production in these @entity0 .

title: @entity6 is required for maintenance of marginal zone B cells in @entity7 -induced XXXX .

answer: @entity3


abstract: The assessment of @entity1 angiogenesis in @entity4 is presently a subject of intensive research with potential clinical applications. In this study, the expression of @entity2 and @entity3 was examined by immunohistochemistry in 67 @entity1 samples obtained from @entity4 @entity0 treated by radical resection. Distribution of age, sex, @entity1 stage and histology was typical for @entity0 population in Poland. @entity2 expression (more than 25% of positive cells) was noted in 65% of @entity1 cells. @entity3 expression was observed in 91% of @entity1 cells. Neither the number of positive cells nor the staining intensity correlated with the clinical variables (all p values >0.05, chi-square test). No correlation was noted between the expression of @entity2 and @entity3 (p=0.35, chi-square test). In survival analysis, neither the number of positive cells nor the staining intensity of both molecules was of prognostic significance. The expression of @entity2 and @entity3 in @entity4 cells was confirmed in this study. The relation to clinical variables and survival will be further assessed in a larger group of @entity0 .

title: Expression of @entity2 ( @entity2 ) and its receptor @entity3 in @entity4 ( XXXX )--a preliminary report.

answer: @entity4


abstract: UNASSIGNED: Abstract Introduction: Skin @entity1 incidence is increasing in younger adults. @entity0 satisfaction and quality of life surveys are limited, and more information is needed on the unique perspectives of these younger @entity0 who may be affected differently. We sought to explore how @entity2 has affected quality of life in younger adults. Methods: A self-reported questionnaire was administered to @entity0 with @entity2 aged 20-50 years diagnosed from 2007 to 2008. Quality of life was measured using the @entity2 Index (SCI) and Skindex-16 with a transformed scale. Descriptive statistics with standard deviations were calculated. Results: One-hundred sixty-one @entity0 were identified; 62 completed surveys (38.5%), with 47 @entity0 eligible for inclusion. Forty @entity0 (85%) reported having made lifestyle changes since being diagnosed with @entity2 , most commonly habitual use of sunscreen (n   =   34; 77.3%). Quality of life was most @entity2 (Skindex-16 score 24.5 (34.4 standard deviation)), including their future risk of developing further @entity1 (58.5 (31.8)). Limitations: Limitations include small sample size and possible response bias. Conclusions: There is a modest impact on quality of life in young @entity0 with @entity2 based on the Skindex-16 and SCI. Young @entity2 survivors may benefit from @entity0 counseling, which addresses risk assessment and future risk reduction.

title: Self-reported quality of life after XXXX in young adults.

answer: @entity2


abstract: PURPOSE: @entity2 is characterized by @entity1 following injury  to the developing brain. Neurogenic lower urinary tract dysfunction is estimated to affect at least a third of @entity0 with @entity2 . However there  are limited data as @entity0 transition to adulthood. We sought to describe the symptoms, sequelae and management of @entity5 in adults with @entity2 . MATERIALS AND METHODS: We retrospectively reviewed the charts of adult @entity0 with @entity2 between 2011 and 2014. @entity0 with prior bladder reconstruction or catheterization based bladder drainage were excluded from study. @entity2 severity was determined using GMFCS (Gross Motor Function Classification System). A conservative evaluation and treatment paradigm was used. Noninvasive treatments were encouraged. Specifically clean intermittent catheterization, which is often not feasible, is avoided unless urinary retention, @entity6 or refractory lower urinary tract symptoms develop. RESULTS: There were 121 @entity0 included in final analysis. Median age was 25  and 61 @entity0 (50%) had GMFCS level V. Noninvasive management failed in  28 of 121 @entity0 (23%) as defined by @entity6 in 9, persistent urinary retention in 10 and refractory lower urinary tract symptoms/ @entity3 in 9. Urethral clean intermittent catheterization was poorly tolerated. Of all @entity0 25% showed evidence of @entity4 during the study period. Surgical intervention was rare and associated with significant morbidity. CONCLUSIONS: Adults with @entity2 may present with variable signs and symptoms of @entity5 . Conservative treatment was successful in more than 75% of @entity0 . Clean intermittent catheterization was poorly tolerated in @entity0 in whom conservative treatment failed. Surgical intervention was rarely indicated and it should be reserved for select individuals.

title: Neurogenic Lower Urinary Tract Dysfunction in Adults with XXXX : Outcomes following a Conservative Management Approach.

answer: @entity2