abstract: The clinical course of @entity1 grade 2 (A2) is highly variable and is not reflected by morphological characteristics. Earlier studies using small series of A2 cases suggest that in situ hybridization (ISH) with chromosome-specific DNA probes allows for frequent detection of aneusomy 1, trisomy 7, and monosomy 10. The role of trisomy 7 in @entity0 is disputed, however, because of its presence in non-neoplastic brain tissue, as detected by karyotyping. Our objective was to investigate whether there was a correlation between chromosomal aberrations and survival in a series of 47 cases of A2. All cases were evaluated for numerical aberrations of chromosomes 1, 7, and 10 by ISH. @entity2 were detected in 68% of cases of A2. @entity3 was seen in 31 cases (66%), 22 of which (47%) had a high percentage of this numerical aberration. Only 11 of these 22 cases also showed aneusomy for 1 or 10. No cells or only a few cells with aberrations were detected in non-neoplastic control samples. Using Kaplan-Meier analysis, @entity3 correlated significantly with shorter survival. Hence, as determined by ISH, @entity3 is absent in non-neoplastic brain tissue and is frequently detected in A2, correlating with the malignant progression of the disease.

title: Gain of chromosome 7, as detected by in situ hybridization, strongly correlates with shorter survival in XXXX grade 2.

answer: @entity1


abstract: OBJECTIVE: To determine if the long-term use of @entity7 ( @entity8 ) in @entity3 ( @entity3 ) is associated with the development of significant @entity9 , and to describe the presence of risk factors for @entity9 in @entity0 with @entity3 . METHODS: Needle biopsies of the liver were performed on a cross-section cohort of 14 @entity0 with @entity3 who had received a total cumulative dose of @entity8 that was either > 3,000 mg or > 4,000 mg/1.73 m2 of body surface area. Biopsy samples were independently graded according to the Roenigk Classification Scale by 2 pathologists. The presence of risk factors for @entity8 hepatotoxicity, especially biochemical @entity4 and @entity2 consumption, were assessed. RESULTS: Thirteen biopsy samples (93%) were classified as grade I, and 1 (7%) as grade II; none demonstrated significant @entity1 . However, histologic abnormalities were found in 13 biopsy samples (93%). Only 2 @entity0 (14%) consumed more than 1 alcoholic drink per month. Thirteen @entity0 (93%) had biochemical abnormalities while being treated with @entity8 , but only 5 @entity0 (36%) had at least 1 determination in which the @entity5 or @entity6 aminotransferase elevation was > 3 times the upper limit of normal. CONCLUSION: Long-term use of @entity8 for @entity3 does not appear to be associated with the development of significant @entity9 . Although nearly all @entity0 had minor histologic changes, no significant clinical consequences were apparent. A prospective study of a larger population will more accurately define the incidence of @entity8 -related @entity9 and appropriate monitoring guidelines in @entity3 .

title: The long-term effect of @entity7 therapy on the liver in @entity0 with XXXX .

answer: @entity3


abstract: On the basis of recent clinical data suggesting that high-dose continuous @entity10 ( @entity10 ) is able to overcome resistance to @entity10 bolus application in @entity4 , a phase II study was performed to evaluate the activity and @entity2 of weekly high-dose @entity10 and @entity12 plus biweekly alternating @entity6 and @entity8 as the first-line treatment in @entity0 with advanced @entity4 . Between October 1995 and September 1997, 24 consecutive @entity0 with locally advanced (n=4) or metastatic (n=20) @entity4 were treated with a combination of 500 mg/m2 @entity12 as a 2-h infusion, followed by 2.0 g/m2 @entity10 as a 24-h continuous infusion once weekly for 6 weeks, plus 20 mg/m2 @entity6 as a bolus application and 50 mg/m2 @entity8 as a 1-h infusion, week 1, 3 and 5 ( @entity11 regimen). Response, @entity2 and survival data were evaluated. A total of 20 @entity0 were evaluable for response and 24 for @entity2 . Objective responses were observed in 11 @entity0 (55%) with no complete remission. Four @entity0 (20%) showed stabilization and 5 @entity0 (25%) experienced @entity1 . The median time to disease progression was 8 months and the overall duration of survival was 14 months. Myelosuppression was significant. In 2 @entity0 , grade 4 WHO @entity7 and @entity9 / @entity5 respectively were registered, but there were no treatment-related @entity3 . We conclude that the weekly alternating @entity11 regimen is effective in advanced @entity4 with tolerable @entity2 . However, significant myelotoxicity and frequent hospitalization suggest that @entity11 should not be preferred to other regimens used in metastatic disease. Currently we intend to establish this regimen in the neoadjuvant setting in @entity0 with primary unresectable localized @entity4 .

title: A phase II study of weekly high-dose @entity10 and XXXX plus biweekly alternating @entity6 and @entity8 for advanced @entity4 .

answer: @entity12


abstract: PURPOSE: To determine the prevalence and incidence of short wavelength automated perimetry deficits in comparison to standard automated perimetry deficits in @entity0 with @entity4 . METHODS: Five hundred eyes of 250 @entity0 with @entity4 were recruited into a prospective, longitudinal study and tested with standard automated perimetry and short wavelength automated perimetry annually for 5 years. Both eyes of 60 normal subjects, 21 to 85 years of age, were used to establish normative data for short wavelength automated perimetry and standard automated perimetry. This allowed independent evaluation of left and right eyes of @entity0 . All normal data were corrected for age, and short wavelength automated perimetry results were corrected for lens transmission. The lowest fifth and first percentiles for the normal observers were derived for the 10 @entity3 hemifield test zones for short wavelength automated perimetry and standard automated perimetry. Visual fields were considered outside normal limits if two @entity3 hemifield test zones were below the normal fifth percentile or one @entity3 hemifield test zone was below the normal first percentile. RESULTS: Baseline prevalence of short wavelength automated perimetry and standard automated perimetry deficits were 9.4% and 1.4%, respectively. During the study, incident rates of field loss were 6.2% (1.23% per year) for short wavelength automated perimetry and 5.9% (1.18% per year) for standard automated perimetry. Once abnormal, 80% of short wavelength automated perimetry fields remained abnormal on the next examination, whereas only 45% of abnormal standard automated perimetry fields remained abnormal. New short wavelength automated perimetry deficits in ocular @entity2 were more prominent and more persistent than new standard automated perimetry deficits. CONCLUSIONS: Our findings are consistent with the interpretation that short wavelength automated perimetry deficits occur before standard automated perimetry deficits in @entity3 . The similar incidence rates suggest that both standard automated perimetry and short wavelength automated perimetry are monitoring the same underlying @entity1 process.

title: Incidence and prevalence of short wavelength automated perimetry deficits in ocular @entity2 XXXX .

answer: @entity0


abstract: Rotation of the @entity1 is powered by a transmembrane gradient of protons or, in some species, @entity0 ions. The molecular mechanism of coupling between ion flow and motor rotation is not understood. The proteins most closely involved in motor rotation are MotA, MotB, and FliG. MotA and MotB are transmembrane proteins that function in transmembrane proton conduction and that are believed to form the stator. FliG is a soluble protein located on the cytoplasmic face of the rotor. Two other proteins, FliM and FliN, are known to bind to FliG and have also been suggested to be involved to some extent in torque generation. Proton (or @entity0 )-binding sites in the motor are likely to be important to its function and might be formed from the side chains of acidic residues. To investigate the role of acidic residues in the function of the flagellar motor, we mutated each of the conserved acidic residues in the five proteins that have been suggested to be involved in torque generation and measured the effects on motility. None of the conserved acidic residues of MotA, FliG, FliM, or FliN proved essential for torque generation. An acidic residue at position 32 of MotB did prove essential. Of 15 different substitutions studied at this position, only the conservative-replacement @entity3 mutant retained any function. Previous studies, together with additional data presented here, indicate that the proteins involved in motor rotation do not contain any conserved basic residues that are critical for motor rotation per se. We propose that @entity2 32 of MotB functions as a proton-binding site in the @entity1 and that no other conserved, protonatable residues function in this capacity.

title: Function of protonatable residues in the flagellar motor of Escherichia coli: a critical role for XXXX 32 of MotB.

answer: @entity2


abstract: Conflicting data on the inotropic effect of insulin are present in the literature suggesting a positive inotropic property or no inotropic effect or even a negative influence. To clarify the reason for these diverging findings, dose-response curves of insulin have been performed in isolated working @entity1 and @entity3 hearts perfused with Krebs-Henseleit buffer containing 0.9, 1.25, 2.5, and 5 mM @entity2 at 37 degrees C. At 1.25 mM [ @entity2 ], insulin (8 to 16 IU) regularly improved the inotropic state. LVdP/dt(max) increased significantly from 1,900 to 2,300 mm Hg/s (+21 %) in @entity3 hearts and from 3,197 to 4,345 mm Hg/s (+36 %) in @entity1 hearts. LVEDP did not change significantly. Myocardial @entity0 consumption increased parallel with contractility. Heart rate was not influenced in either species. Coronary flow increased by 16.5 % in @entity3 hearts, but decreased in @entity1 hearts by 13.6 % (p < 0.05 each). With 0.9 mM [ @entity2 ] the positive inotropic effect of insulin did not further augment. At 2.5 mM [ @entity2 ] insulin exhibited in both species no significant change of LVdP/dt(max) but very high insulin doses depressed the heart. At 5 mM [ @entity2 ] insulin depressed the heart significantly already at lower concentrations. At 31 degrees C and 1.25 mM [ @entity2 ] the positive inotropic insulin effect was preserved. We conclude that the positive inotropic insulin effect in @entity1 and @entity3 hearts depends on the extracellular [ @entity2 ], i.e., is maximal around 1.25 mM [ @entity2 ] and is reduced or absent at higher [ @entity2 ] or may even become negative.

title: Influence of perfusate calcium concentration on the inotropic insulin effect in isolated XXXX and @entity1 hearts.

answer: @entity3


abstract: @entity1 has been associated with subclinical @entity5 and increased risk of @entity4 . Few data are available on the relative contribution of @entity6 distribution and changes in myocardial structure and function. We evaluated the influence of visceral versus subcutaneous abdominal adipose tissue and epicardial fat on LV diastolic function after acute @entity3 . One month after acute @entity3 , 225 consecutive @entity0 were prospectively enrolled and underwent anthropometric evaluation, bioimpedance analysis, detailed echocardiography, and multidetector 64-slice computed tomography scan for quantification of epicardial fat volume (EFV) and of total, subcutaneous and visceral abdominal fat areas. We found a significant association between LV @entity2 parameters and body mass index, fat-mass percentage, and waist-to-height ratio. E' velocity and E/E' ratio were correlated with total and visceral abdominal fat (r  =  -0.27, p <0.001 and r  = 0.21, p <0.01, respectively), but not with subcutaneous fat. After multivariate analysis, increasing EFV was associated with decreased E' velocity (adjusted b  -0.11, 95% confidence interval  -0.19 to  -0.03; p <0.01) and increased E/E' ratio (adjusted b 0.19, 95% confidence interval 0.07 to 0.31, p <0.01). @entity0 with @entity2 showed higher EFV (116.7    67.9  ml vs 93.0    52.3  ml, p  = 0.01), and there was a progressive increase in EFV according to @entity2 grades (p  = 0.001). None of the @entity6 parameters correlated with ejection fraction or S' velocities. In conclusion, in @entity0 after @entity3 , impaired LV diastolic function was associated with increased @entity6 , especially with visceral and central fat parameters. Increasing EFV was independently associated with worse LV diastolic function.

title: Influence of Epicardial and Visceral Fat on Left Ventricular Diastolic and Systolic Functions in XXXX After @entity3 .

answer: @entity0


abstract: 1. Spontaneous non-synaptic @entity2 was induced by bathing @entity0 hippocampal slices in low- @entity1 solution. Extracellular recordings from electrodes placed on both sides of a complete cut showed that non-synaptic activity was synchronized across the lesion. 2. Ion-selective electrode recordings showed that each event was accompanied by a transient increase in extracellular @entity3 that diffused across the lesion. The synchrony was destroyed when a thin film was inserted into the lesion site. 3. Local pressure ejection of KCl evoked an event that subsequently propagated across the lesion. 4. After a complete lesion was made, afterdischarges evoked on one half of a slice were not detected on the other half. 5. Voltage-sensitive dye imaging methods showed that @entity2 activity propagated across the mechanical lesion without significant attenuation or additional delays. The velocity of the activity was consistent with that of the slow diffusion of a @entity3 wave. 6. Since field effects were significantly attenuated across the lesion and all gap junctions and cell processes across the lesion would be cut, these data show that extracellular diffusion, most probably @entity3 , is sufficient to synchronize populations of neurons and propagate slow frequency @entity2 .

title: Propagation of non-synaptic XXXX across a lesion in @entity0 hippocampal slices.

answer: @entity2


abstract: AIM: To analyze the hepatic and intestinal microcirculation in an animal model of @entity6 and @entity0 ( @entity0 ) and to characterize the anti-inflammatory action of @entity7 ( @entity7 ) on leukocyte kinetics and @entity4 . METHODS: Hepatic and intestinal microcirculation was investigated by intravital videomicroscopy. Standardized models of experimental chronic @entity6 and @entity1 were employed. Animals were divided into four groups (n = 6/group): controls, animals with @entity2 , animals with @entity2 and @entity0 , animals with @entity2 and @entity0 treated with @entity7 . RESULTS: @entity2 facilitated leukocyte rolling and sticking in hepatic sinusoids (1.91+/-0.28 sticker/microm vs 0.5+/-0.5 sticker/microm in controls, P<0.05). The effect enhanced in animals with @entity2 and @entity0 (5.4+/-1.65 sticker/microm), but reversed after @entity7 application (3.97+/-1.04 sticker/microm, P<0.05). Mucosal blood flow showed no differences in cirrhotic animals and controls (5.3+/-0.31 nL/min vs 5.4+/-0.25 nL/min) and was attenuated in animals with @entity2 and @entity0 significantly (3.49+/-0.6 nL/min). This effect was normalized in the treatment group (5.13+/-0.4 nL/min, P<0.05). Enzyme values rose during development of @entity2 and @entity1 , and reduced after @entity7 application (P<0.05). CONCLUSION: @entity6 in the presence of @entity0 leads to a significant @entity5 flow and an increase in hepatic leukocyte adherence with consecutive @entity3 , which can be prevented by administration of @entity7 .

title: Impact of XXXX on hepatic and intestinal microcirculation in experimental @entity6 and @entity1 : an in vivo analysis.

answer: @entity7


abstract: UNASSIGNED: Tendons are elastic structures that connect muscle to the skeletal system and transmit force relative to the amount of stretch they experience. The mechanical properties of @entity0 tendons are difficult to measure non-invasively, so generic values are often assumed in musculoskeletal models to represent all subjects. We aimed to determine the in vivo mechanical properties of the @entity0 Achilles tendon by calculating @entity1 in 10 male and 10 female trained cyclists. B-mode ultrasound coupled with motion capture was used to track the tendon lengths for the medial and lateral gastrocnemii concurrently with ankle torque measurements during ramped isometric contractions. Achilles tendon @entity2 was calculated as the slope of the linear portion of the force-length curve, and this was extrapolated to zero force to yield the tendon resting length. Average Achilles tendon @entity2 was 201.8  5.9Nmm(-1). There was no difference in Achilles tendon @entity2 or maximum isometric force between males and females, however tendon @entity2 varied between individuals. The resting lengths of the MG and LG tendon were 0.209  0.002m and 0.222  0.002m respectively, and regression models determined that @entity3 length was the best predictor of resting tendon length. Our results indicate that Achilles tendon @entity2 varies with muscle strength and not sex. The variability in Achilles tendon @entity2 between subjects support the need for experimentally measured subject-specific tendon properties as input parameters to improve the accuracy of musculoskeletal models.

title: Structural and mechanical properties of the XXXX Achilles tendon: Sex and strength effects.

answer: @entity0


abstract: BACKGROUND: @entity3 and @entity2 are common after @entity1 . There is inconclusive evidence of the benefit of psychotherapy for @entity3 and @entity2 . Here, we used a brief intervention, Neuro-Linguistic Programming (NLP) brief therapy plus health education, to evaluate the changes in @entity0 with @entity4 . METHODS: One hundred eighty @entity0 were randomly allocated to receive 4 sessions of NLP plus health education (n  =  90) or usual care (n  =  90). A set of questionnaires was used preintervention and postintervention as well as at the 6-month follow-up. The primary outcomes were the prevalence of @entity3 and @entity2 , and the awareness of @entity1 knowledge. RESULTS: More @entity0 in the intervention group achieved remission of @entity3 (odds ratio [OR], 2.81; 95% confidence interval [CI], 1.41-5.59) and @entity5 (OR, 2.19; 95% CI, 1.15-4.18) after intervention. At the 6-month follow-up, we found no differences between groups in both the prevalence of @entity3 and @entity2 . After intervention, the intervention group had better awareness rates on most of the @entity1 knowledge items (P  <  .05). It also had better quality of life and physical function both after intervention and at the follow-up (P  <  .05). CONCLUSIONS: NLP plus health education could reduce @entity3 and @entity2 immediately after intervention, but not at the 6-month follow-up. The intervention could also improve the awareness of @entity1 knowledge and benefit @entity0 on quality of life and physical function.

title: The Effect of a Brief Intervention for @entity0 with XXXX : A Randomized Controlled Trial.

answer: @entity4


abstract: To investigate the susceptibilities of fungal and @entity0 cells to @entity2 ( @entity7 ), @entity7 -loaded @entity6 (LPC)micelles as drug delivery vehicles were incubated at 37 degrees C with @entity3 vesicles containing different @entity4 as model systems for fungal and @entity0 cells. The binding and kinetics of @entity7 to @entity4 in the membranes were judged by UV-visible spectroscopy. In the 91% monomeric form, @entity7 interacted rapidly with @entity8 and slowly with @entity9 ( @entity9 ), while it did not interact with @entity1 . In the 50% monomeric form, @entity7 formed complexes more rapidly with @entity8 or @entity9 than in the monomeric form, whereas it did not still interact with @entity1 . The interaction was also characterized by resonance energy transfer between the fluorescent probe @entity10 ( @entity10 ) and @entity7 . In the 91% monomeric form, @entity7 caused initial fluorescence quenching in bilayer membranes containing any @entity5 as well as @entity5 -free bilayer membranes due to the release of @entity7 and its incorporation within the membranes. However, a second phase of increasing fluorescence was found in the case of @entity8 alone. On the other hand, in the 47% monomeric form, @entity7 gave a biphasic intensity profile in membranes containing any @entity5 as well as @entity5 -free membranes. However, the extent of the second phase of increasing fluorescence intensity was markedly dependent upon @entity5 composition. Studies using @entity5 -containing vesicles provide important insights into the role of the aggregation state of @entity7 in its effects on cells.

title: Susceptibilities of phospholipid vesicles containing different @entity4 to XXXX -loaded lysophosphatidylcholine micelles.

answer: @entity2


abstract: Aims and background. @entity4 enzyme plays an important role in the metabolism of carcinogens, such as @entity2 , nitroaromatics and @entity5 . Methods. The study examined the association of @entity4 @entity6 polymorphism with the risk of developing @entity1 in a Chinese population. We conducted a case-control study including 526 @entity1 cases and 526 @entity0 -free controls. The odds ratios and 95    confidence intervals were calculated by logistic regression models. Results. Compared with 462Ile/Ile genotype carriers, subjects with @entity4 462Ile/ @entity3 or @entity3 / @entity3 genotype had a decreased risk of developing @entity1 with odds ratios of 0.57 (95% CI, 0.44-0.75) and 0.54 (95% CI, 0.36-0.81), respectively. When stratified by smoking status, the decreased risk of @entity1 associated with @entity4 462Ile/ @entity3 or @entity3 / @entity3 genotype was observed among non-smokers (OR = 0.62, 95% CI, 0.45-0.87) and among smokers (OR = 0.54, 95% CI, 0.37-0.78). When stratified by smoking-dose, the correlation between @entity4 genotypes and the risk of @entity1 was detected among light smokers (OR = 0.30, 95% CI, 0.19-0.48) but not among heavy smokers (OR = 0.93, 95% CI, 0.61-1.43). Conclusions. The @entity4 @entity6 variant was associated with a low risk of developing @entity1 in a Chinese population.

title: @entity4 @entity6 polymorphism and the risk of XXXX in a Chinese population.

answer: @entity1


abstract: INTRODUCTION: @entity2 administration to @entity0 about to undergo neurosurgery must be avoided because perioperative @entity4 in a context of @entity6 worsens the neurological prognosis. Furthermore, prolonged @entity5 can also provoke lesions that resemble those occasioned by states of @entity1 - @entity3 . OBJECTIVES: To evaluate glycemic changes in @entity0 undergoing craniotomy who have not received @entity2 -containing solutions. @entity0 AND METHODS: Forty-six @entity0 were enrolled and assigned to two groups according to whether they received perioperative corticoid treatment (CC, n = 24) or not (NCC, n = 22). Fasting was maintained without administration of @entity2 -containing solutions. We measured glycemia, natremia and potassemia at baseline and 60 minutes after surgery. RESULTS: Demographic characteristics, duration of surgery (5.0 +/- 1.6 h in the CC group and 4.6 +/- 1.4 h in the NCC group) and fasting period (18 +/- 2.3 h in the CC group and 17 +/- 1.9 h in the NCC group) were similar in both groups. Glycemia increased and natremia decreased significantly in both groups, with no clinical repercussions. No case of perioperative @entity5 occurred. Initial potassemia in the CC group was significantly higher than in the NCC group, but decreased after surgery with no clinical repercussions. No relation was found between fasting time, duration or surgery and differences in glycemia between the two groups. CONCLUSION: Non-administration of @entity2 in @entity0 undergoing craniotomy eliminates the risk of @entity6 , does not lead to perioperative @entity5 and is not affected by perioperative corticoid treatment.

title: [Fluid therapy without XXXX in neurosurgery. Effect on glycemia].

answer: @entity2


abstract: BACKGROUND: @entity2 constitute a major health problem all over the world. Signs and symptoms induced by various @entity1 are difficult to distinguish clinically from each other. So, characterization by in vitro culture is required for appropriate diagnosis and treatment as well as to study the epidemiological characteristics in a region. OBJECTIVES: The present retrospective work was aimed to study the spectrum of @entity2 of the skin, nails and hairs in the Capital area of Kuwait over a span of 5 years and to compare the results with those reported earlier from this region and other parts of the world. @entity0 /MATERIALS: The study was conducted on 2,730 @entity0 referred from dermatology outpatients to mycology laboratory suspected to have @entity2 over a 5-year period. Identification of dermatophyte isolates obtained was done by conventional microscopic examination in all @entity0 , whereas culture techniques were performed for 1,593 of them. RESULTS: Among 2,730 @entity0 , 1,437 were @entity0 and 1,293 were @entity0 with a @entity0 to @entity0 ratio of 1.1:1. The age ranged from 3 months to 70 years (mean age 28.5 years). The clinical diagnosis of these @entity0 was as follows: @entity8 ; @entity6 corporis; @entity6 @entity5 ; @entity6 pedis; @entity6 ; @entity6 manum and @entity14 . @entity7 ( @entity4 ) examination showed positive results in 39% of all cases, whereas positive cultures were obtained in 29% of cultured specimens. Among dermatophytes, six species were isolated: @entity12 (39%), @entity13 (16%), @entity10 (10%), @entity15 (6.2%), @entity11 violaceum (2.4%) and @entity11 (0.4%). @entity12 was isolated from all body sites. Candida and @entity9 were isolated on @entity3 -free cultures in cases with @entity8 . CONCLUSIONS: @entity2 including dermatophytes remain prevalent in this part of the world. The most common isolate was @entity12 followed by Candida species. The least isolate was @entity11 . Species identification in relation to factors such as time, place and population is warranted in order to implement treatment regimens and to propose potential control measures.

title: The spectrum of XXXX with a special reference to dermatophytoses in the capital area of Kuwait during 2000-2005: a retrospective analysis.

answer: @entity2


abstract: UNASSIGNED: @entity7 , a chemotherapeutic used for the treatment of solid @entity1 , has nephrotoxic side effects leading to @entity6 ( @entity6 ). @entity7 cannot be given to @entity0 that have comorbidities that pre-dispose them to an increased risk for @entity6 . Even without these comorbidities, 30% of @entity0 administered @entity7 will develop @entity2 , requiring the oncologist to withhold or reduce the next dose, leading to a less effective therapeutic regimen. Although recovery can occur after one episode of @entity7 -induced @entity6 , longitudinal studies indicate that multiple episodes of @entity6 lead to the development of @entity5 ( @entity5 ), an irreversible disease with no current treatments. The standard @entity3 model of @entity7 -induced @entity6 consists of one, high dose of @entity7 (> 20 mg/kg) that is lethal to the animal three days later. This model does not accurately reflect the dosing regimen @entity0 receive nor does it allow for the long-term study of kidney function and biology. We have developed a repeated dosing model whereby @entity7 is given once a week for four weeks. Comparison of the repeated dosing model to the standard dosing model demonstrated that inflammatory cytokines and chemokines were induced in the repeated dosing model, but levels of cell death were lower in the repeated dosing model. The repeated dosing model had increased levels of fibrotic markers (fibronectin, @entity9 , and @entity8 ) and interstitial @entity4 . These data indicate that the repeated dosing model can be used to study @entity6 to @entity5 progression, as well as the mechanisms of this progression.

title: Repeated Administration of Low-Dose @entity7 in XXXX Induces @entity4 .

answer: @entity3


abstract: We report a @entity0 with unusual @entity4 . A 24-year-old Japanese female was hospitalized in October 1995 because of @entity8 . Lobular form @entity4 with @entity12 associated with massive wide-spread accumulation of slightly eosinophilic, @entity11 Schiff-positive amorphous materials in the luminal side of the capillary walls and paramesangial area was observed in the renal biopsy specimen. Immunofluorescent study revealed massive strong staining for IgM and C4 along the capillary walls and in the mesangium. Deposits of IgA, IgG, C3 and fibrinogen were also observed. Electron microscopy showed normal thickness of the capillary basement membrane and a large amount of subendothelial and paramesangial electron dense, finely granular deposits without fibrils or tubular structures. There were no clinical or laboratory findings of @entity2 , such as @entity6 and @entity13 . Therefore, we believed that this case involved an unusual idiopathic @entity1 with massive subendothelial and @entity5 . @entity4 in this @entity0 appeared to be resistant to treatment with @entity3 and that this @entity1 may be a progressive disease as shown during the 3-year observation. Furthermore, our @entity0 had @entity10 and @entity7 . However, the relationship between @entity4 and @entity9 in our @entity0 is unknown.

title: Lobular form idiopathic @entity4 with massive subendothelial and XXXX , a three-year follow-up case.

answer: @entity5


abstract: The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for @entity2 in predicting @entity3 ( @entity3 ). This study included 48 @entity0 with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2-weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict @entity3 . @entity3 was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable @entity1 on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of @entity3 , but only enhancing tissue on subtraction images remained a significant predictor of @entity3 (P=0.018) in the multivariate analysis. @entity3 was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P<0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer @entity3 .

title: MRI Findings and Prediction of Time to Progression of XXXX with @entity2 Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization.

answer: @entity0


abstract: UNASSIGNED: 161 Background: A new @entity1 therapeutic gene; @entity3 was found in Okayama university in 2000. In vivo experiments have demonstrated outstanding @entity1 -selective apoptosis effects and anti- @entity1 immunoactivity against various types of @entity1 . With these positive experimental results, a phase I/II study of @entity4 -mediated @entity3 gene therapy for @entity2 was initiated from January 2011 in Okayama university hospital. METHODS: Two major inclusion criteria category were set up; A: A recurrence of @entity2 following definitive endocrine therapy with/without metastasis, B: A @entity2 which was considered high risk of recurrences following radical surgery according to a nomogram reported by Kattan et al. Replication-defective @entity4 vector expressing @entity3 (Ad- @entity3 ) was injected directly into the prostate (or metastatic lesion in @entity0 who received prostatectomy) in escalating doses from 1.0*10(10) to 1.0*10(12) viral particle (vp). Each @entity0 in category A received total of 2 times viral injections every 4 weeks. @entity0 in category B also received total of 2 times viral injections every 2 weeks, then received radical prostatectomy 6 weeks after second viral injection. RESULTS: Three @entity0 in category A, and 9 @entity0 in category B were entered the present study. No significant side effects were observed. In category B, signs of immunological responses in surgically removed specimens (apoptosis induction of @entity1 cells in TUNEL staining and infiltration of CD8 positive cells (CTL) in immunohistochemical staining) were observed in second dose. These responses were remarkably observed in the third dose. CONCLUSIONS: This initial and preliminary report suggests the favorable safety profile and positive clinical responses in a clinical trial of Ad- @entity3 gene therapy for @entity2 .

title: A phase I/II study of @entity4 -mediated reduced expression in immortalized cells ( XXXX ) gene therapy for @entity2 : An interim report.

answer: @entity3


abstract: Streptococci have been considered to lack the classical SOS response, defined by increased mutation after UV exposure and regulation by LexA. Here we report the identification of a potential self-regulated SOS mutagenesis gene cassette in the Streptococcaceae family. Exposure to UV light was found to increase mutations to antibiotic resistance in @entity5 cultures. The mutational spectra revealed mainly G: @entity6 :T transitions, and Northern analyses demonstrated increased expression of a Y-family DNA polymerase resembling UmuC under DNA-damaging conditions. In the absence of the Y-family polymerase, @entity5 cells were sensitive to UV light and to @entity0 . Furthermore, the UV-induced mutagenesis was almost completely abolished in cells deficient in the Y-family polymerase. The gene encoding the Y-family polymerase was localized in a four-gene operon including two hypothetical genes and a gene encoding a HdiR homolog. Electrophoretic mobility shift assays demonstrated that @entity5 HdiR binds specifically to an inverted repeat sequence in the promoter region of the four-gene operon. Database searches revealed conservation of the gene cassette in several @entity2 species, including at least one genome each of @entity1 , @entity3 , @entity4 , @entity2 sanguinis, and @entity2 strains. In addition, the umuC operon was localized in several mobile DNA elements of @entity2 and Lactococcus species. We conclude that the hdiR-umuC-ORF3-ORF4 operon represents a novel gene cassette capable of mediating SOS mutagenesis among members of the Streptococcaceae.

title: Identification of a novel streptococcal gene cassette mediating SOS mutagenesis in XXXX .

answer: @entity5


abstract: BACKGROUND: @entity10 has been shown to exert antistress effects both in vitro and in vivo. However, the effects of @entity10 on stress in brain cells are not well understood. This study investigated how Korean Red @entity10 (KRG) controls @entity4 -induced apoptosis via regulation of @entity9 -3 kinase (PI3K)/Akt and @entity3 receptor (ER)-b signaling. METHODS: @entity0 @entity6 SK-N-SH cells were pretreated with KRG and subsequently exposed to @entity5 . The ability of KRG to inhibit oxidative stress-induced apoptosis was assessed in @entity1 @entity2 assays. Apoptotic protein expression was examined by Western blot analysis. The roles of ER-b, PI3K, and p-Akt signaling in KRG regulation of apoptosis were studied using small interfering RNAs and/or target antagonists. RESULTS: Pretreating SK-N-SH cells with KRG decreased expression of the proapoptotic proteins p-p53 and @entity7 , but increased expression of the antiapoptotic protein @entity8 . KRG pretreatment was also associated with increased ER-b, PI3K, and p-Akt expression. Conversely, ER-b inhibition with small interfering RNA or inhibitor treatment increased p-p53 and @entity7 levels, but decreased @entity8 , PI3K, and p-Akt expression. Moreover, inhibition of PI3K/Akt signaling diminished p-p53 and @entity7 levels, but increased @entity8 expression. CONCLUSION: Collectively, the data indicate that KRG represses oxidative stress-induced apoptosis by enhancing PI3K/Akt signaling via upregulation of ER-b expression.

title: Korean Red @entity10 inhibits apoptosis in @entity6 cells via @entity3 receptor b-mediated XXXX -3 kinase/Akt signaling.

answer: @entity9


abstract: UNASSIGNED: @entity1 in older adults erodes their health, quality of life and the economy. Existing interventions are not feasible for broad application at the community. Postcard intervention only requires a few resources, and previous studies have shown its effectiveness for @entity0 following drug @entity2 , self-harm and hospitalisation for major @entity1 . The purpose of the present study is to evaluate the effectiveness of a postcard intervention. @entity0 were community-dwelling individuals, aged 65 or older, who eat meals alone and with the score of 4 or higher on the 15-item Geriatric @entity1 Scale (GDS-15). We enrolled 184 eligible @entity0 , with 93 in the intervention and 91 in the control arm. Postcards were sent to @entity0 once a month for eight months. Primary outcome was the GDS-15 score at post-intervention. Secondary outcomes were quality of life and activities of daily living. There was no significant difference in primary and secondary outcomes between completers of the intervention and the control arm. However, most of the @entity0 who received intervention thought the intervention was effective. The postcard intervention for @entity1 in community-dwelling elderly @entity0 in Japan is neither feasible nor effective. However, the descriptive results suggest that the intervention may be effective given different parameters.

title: Postcard intervention for XXXX in community-dwelling older adults: A randomised controlled trial.

answer: @entity1


abstract: @entity1 , @entity2 , diet and starvation, known modulators of the hepatic cytochrome P450 (CYP)-dependent microsomal monooxygenase system, were assessed for their effects on cytochrome P450 isozyme content and monooxygenase activities in the male @entity0 kidney. In acute experiments, @entity0 were either treated with @entity2 , fasted or given a combination of the two treatments. @entity2 treatment alone induced @entity4 -dependent @entity5 hydroxylase activity in kidney microsomes by 8-fold. This was accompanied by a 6-fold increase in @entity4 apoprotein as determined by Western blot analysis. There was, however, no significant increase in steady-state levels of @entity4 mRNA as measured by Northern blot analysis. Starvation also induced @entity4 apoprotein in the kidney and, as has been reported previously in the liver, had a synergistic inductive effect with @entity2 . CYP2B and @entity6 apoproteins were also induced by @entity2 , starvation and starvation/ @entity2 combinations in the kidney. Immunohistochemical analysis revealed localization of @entity4 and CYP2B principally in the cortex associated with tubular cells. This distribution was maintained upon starvation/ @entity2 treatment. Two induction experiments were performed in which the @entity1 was administered as part of a system of @entity3 ( @entity3 ). A short-term study was conducted in which @entity1 was administered for 8 days in two liquid diets of different composition, and a chronic experiment was performed in which @entity1 was administered for 35 days. A diet-independent 6-fold increase in @entity4 apoprotein was observed in the short-term experiment. Expression of @entity6 and CYP2A cross-reactive apoproteins in kidney microsomes appeared to be affected by alterations in diet but, were unaffected by @entity1 treatment. In the chronic 35-day @entity1 exposure experiment, @entity4 apoprotein was also elevated 6-fold and this was found to be accompanied by a significant 3-fold increase in @entity4 mRNA. In the same study, no @entity1 effects were apparent on expression of CYP2B and @entity6 apoproteins. Thus, @entity2 induced a variety of renal cytochrome P450 forms in addition to @entity4 , while @entity1 appeared to be a much more specific renal @entity4 inducer. Furthermore, as reported in the liver, @entity2 and @entity1 appeared to induce @entity4 in the kidney by different mechanisms.

title: Expression and distribution of cytochrome P450 enzymes in male @entity0 kidney: effects of XXXX , @entity2 and dietary conditions.

answer: @entity1


abstract: OBJECTIVE: This study evaluated the efficacy of intravaginal @entity3 gel in comparison with that of a Foley catheter for cervical ripening and induction of labor. STUDY DESIGN: Consecutive @entity0 with unfavorable cervix requiring preinduction cervical ripening and induction of labor at term gestation were asked to participate in the study. One hundred and two @entity0 were assigned to treatment with intravaginal @entity3 gel (group 1) and 122 @entity0 underwent the placement of an intracervical Foley catheter (group 2). After a maximum of three applications of intravaginal @entity3 gel (18h) or after 18h from Foley catheter insertion @entity2 was administered to @entity0 not in active labor. Labor profiles and pregnancy and neonatal outcome were compared between groups. RESULTS: The groups were comparable in term of demographic characteristics, indications for induction of labor, Bishop score at admission. The induction to labor time and the induction to delivery time were similar between groups. The cesarean sections rate was higher in group 1 than in group 2 (26.5 versus 14.7%, P<0.05). This remained significant when the analysis was restricted to nulliparous @entity0 (32.3 versus 14.2%). The incidence of @entity1 , @entity4 , and febrile morbidity was similar between groups. CONCLUSION: For preinduction cervical ripening, the Foley catheter is a valid alternative to the application of intravaginal @entity3 gel and it is associated with a lower cesarean rate in nulliparous @entity0 .

title: Extra-amniotic Foley catheter and XXXX gel for cervical ripening at term gestation.

answer: @entity3


abstract: Abstract Background: The prevalence of the @entity4 ( @entity4 ) increases after the menopause. Reports indicate that the @entity4 and its components, especially @entity1 , enhance the intensity of menopausal symptoms. Objective: Assess the frequency and severity of menopausal symptoms in postmenopausal @entity0 . Factors related to the symptom severity were also analyzed including @entity5 and metabolic status. Methods: A total of 204 natural postmenopausal @entity0 (40-65 years) participating in a @entity4 screening program were asked to fill out the @entity8 ( @entity8 ), the Hospital Anxiety and @entity5 Scale (HADS), and a general socio-demographic questionnaire containing personal and partner data. Criteria of the American Heart Association were used to define the @entity4 . Results: Median age of the whole sample was 56 years. A 52.9% presented the @entity4 , with 37.3% presenting @entity9 , 51.5% @entity2 , 58.3% @entity7 , 45.6% high @entity6 and 56.4% low HDL-C levels. Total and subscale @entity8 scores did not differ in accordance to the presence or not of the @entity4 . The three top prevalent menopausal symptoms were muscle and joint problems (87.2%), physical and mental exhaustion (72%) and @entity5 mood (64.7%). A 19.6% of @entity0 presented @entity8 above 16 defined as severe. Multivariate linear regression analysis determined that @entity3 (higher HADS @entity3 subscale scores) was significantly and positively correlated with all components of the @entity8 (Total and subscale scores). Higher @entity8 correlated positively with abdominal perimeter and higher parity. Somatic scores correlated inversely with female education and positively with psychotropic drug use; and psychological @entity8 scores positively correlated depressed mood (higher HADS @entity5 subscale scores) and abdominal perimeter. Conclusion: In this postmenopausal sample, severity of menopausal symptoms correlated to @entity7 , mood and other personal aspects.

title: Evaluation of the presence and severity of menopausal symptoms among postmenopausal @entity0 screened for the XXXX .

answer: @entity4


abstract: PURPOSE: Ventricular repolarization is assessed using the QT interval corrected by the heart rate (QTc) via an electrocardiogram (ECG). Prolonged QTc is associated with an increased risk of @entity1 and cardiac mortality. As there have been few reports regarding the effects of @entity3 on ventricular repolarization, we studied the association between serum free @entity4 (free T4 [fT4]) and thyroid stimulating hormone (TSH) levels and the QTc interval. METHODS: Thirty-eight @entity0 with @entity3 (<30 years old) were included, and we used their clinical records and available ECGs (between August 2003 and August 2011) to evaluate the association between their fT4 and TSH levels and their QTc interval. In addition, we studied the ECGs of 72 age-matched @entity0 with no @entity3 (control group) and compared their data with that from the @entity0 group. RESULTS: The QTc duration in @entity0 with @entity3 was significantly prolonged compared to that in the control subjects (P<0.001). In addition, the number of @entity3 @entity0 with abnormal prolonged QTc was significantly higher than that in the control group (P<0.001). Among the @entity0 with @entity3 , @entity0 with prolonged QTc and borderline QTc had higher fT4 levels and there was positive correlation between their fT4 levels and their QTc interval (P<0.05). However, no correlation was observed between their TSH levels and their QTc interval. CONCLUSION: We report that @entity3 is associated with @entity2 . The correlation between the fT4 levels and the QTc interval suggests that thyroid status is associated with QTc values and the risk of cardiac mortality.

title: The XXXX in @entity3 and the association of thyroid hormone with the QTc interval.

answer: @entity2


abstract: The effects of @entity5 for Chinese @entity0 with metastatic @entity4 (mRCC) were evaluated to figure out the relationship between clinical variables and prognosis. The data were analyzed retrospectively from six comprehensive @entity2 centers in Northeast China. All cases were diagnosed as mRCC histopathologically without exception. @entity0 were taken 400 mg @entity5 orally twice daily until progression of disease or intolerable toxic reaction occurred. @entity3 ( @entity3 ), progression-free survival (PFS), and the influence of clinical variables on survival were appointed as main outcome measures. Clinical data were analyzed using SPSS statistical software. P<0.05 was considered as statistically significant. A total of 131 @entity0 were available for survival analysis. The median follow-up periods were 16.9 months, and the median @entity3 and PFS were 16.1 months and 10.5 months, respectively. Univariate analysis showed that Eastern Cooperative Oncology Group performance status (ECOG PS), metastatic sites, and previous therapy were significantly associated with @entity3 , whereas PFS was merely associated with ECOG PS and previous therapy. The multivariate analysis suggested that ECOG PS, metastatic sites, and previous therapy were the independent prognostic factors for @entity3 , and ECOG PS and previous therapy as the independent prognostic factors for PFS. In the subgroup analysis for @entity0 with visceral @entity1 , the prognosis of @entity0 with lung @entity1 alone was better than those cases with liver @entity1 alone or multiple organs @entity1 . In our study, @entity5 shows a higher curative activity for @entity0 with mRCC in Northeast China. ECOG PS, metastatic lesions, and previous therapy may be important parameters for @entity3 and PFS prediction. Lung metastases alone may be a more sensitive indicator for @entity5 than other organ metastases.

title: Prognostic analysis of Chinese @entity0 with @entity1 @entity4 receiving XXXX : results from a multicenter long-term follow-up retrospective study.

answer: @entity5


abstract: The @entity3 Questionnaire-Brief Version (SPQ-B), which includes cognitive-perceptual, interpersonal, and disorganized domains, was developed as a concise, self-report measure of schizotypy. This analysis was conducted to: (1) determine the internal consistency reliability of SPQ-B total and subscale scores, (2) use confirmatory factor analysis to assess the three-factor model as well as a single-factor solution, and (3) examine a measure of concurrent criterion validity of SPQ-B scores. The study was conducted at a large, urban, university-affiliated, public-sector health system in the southeastern United States. Data were obtained from 118 @entity0 , including 61 biological relatives of @entity0 with @entity1 , @entity2 , or @entity2 , and 57 non-psychiatric controls. Relatives and controls did not differ significantly on SPQ-B total or subscale scores (or on the full 74-item SPQ total or subscale scores). Internal consistency reliability was adequate for the total SPQ-B score and the interpersonal subscale but was less than ideal for the cognitive-perceptual and disorganized subscales. Regarding the confirmatory factor analysis, though the three-factor solution yielded reasonably good fit to the data, the single-factor solution provided equal fit. Correlations between the three subscales ranged from .63 to .74. With regard to criterion validity, correlations between the SPQ-B total and subscale scores and schizotypy scores derived from a semi-structured, interview-based assessment revealed correlations generally ranging from .40 to .60. The SPQ-B may be a useful brief screening measure of schizotypy, though some limitations in its psychometric properties were evident in this sample. It may be advisable to use total SPQ-B scores rather than subscale scores in some situations, or to use factor analytic techniques to study the instrument's latent structure in specific samples.

title: Psychometric properties of the Brief Version of the @entity3 Questionnaire in relatives of @entity0 with XXXX -spectrum disorders and non-psychiatric controls.

answer: @entity1


abstract: BACKGROUND: Several studies have shown that cultured skin fibroblasts from @entity0 with @entity4 ( @entity4 ) exhibit a @entity5 growth phenotype. Increased DNA synthesis in cells from @entity0 with @entity4 may ultimately involve alterations in cell cycle regulatory proteins. @entity3 protein is a member of @entity3 family of cyclin-dependent kinase inhibitors, which plays an important role in cell cycle regulation. In this study, we examined the correlation between @entity3 protein expression in cultured dermal fibroblasts from type 1 @entity1 @entity0 and the presence of @entity4 . METHOD: Western blot analysis was performed to compare @entity3 protein expression in skin fibroblasts from @entity0 with @entity4 as compared to control subjects, @entity1 @entity0 without @entity4 , and nondiabetic @entity0 with @entity2 . Transcriptional regulation of the @entity3 gene was assessed using competitive reverse transcription-polymerase chain reaction (RT-PCR). Methylation status of the promoter region of @entity3 was examined using methylation-specific PCR, and we used single-stranded conformational polymorphism (SSCP)-PCR to assess @entity3 single-nucleotide polymorphism. RESULTS: Cells from @entity1 @entity0 with @entity4 had nondetectable to significantly lower protein expression of @entity3 . Similarly, mRNA expression of @entity3 was significantly lower in @entity1 @entity0 with @entity4 . No hypermethylation of @entity3 gene was detected, and no abnormal migrating bands were noticed on SSCP-PCR analysis in cells from @entity0 with @entity4 . CONCLUSION: Our data indicate that cells from @entity0 with @entity4 exhibit significantly lower protein and mRNA expression of @entity3 . This study could have not only important implications for the understanding of the pathogenesis of @entity4 , but also the absence of @entity3 may ultimately serve as an early marker for @entity4 .

title: Epigenetic and genetic analysis of @entity3 in dermal fibroblasts from type 1 @entity1 XXXX with @entity2 .

answer: @entity0


abstract: RATIONALE: Cohort studies suggest that airflow obstruction is established early in life, manifests as @entity1 and wheezy @entity3 , and continues into early adulthood. Although an association between @entity1 and @entity2 ( @entity2 ) in later life has been demonstrated, it is unclear if childhood wheezy @entity3 is associated with @entity2 . OBJECTIVES: To investigate whether childhood wheezy @entity3 increases the risk of @entity2 in the seventh decade. METHODS: A cohort of @entity0 recruited in 1964 at age 10 to 15 years, which was followed up in 1989, 1995, and 2001, was followed up again in 2014 when at age 60 to 65 years. Discrete time-to-event and linear mixed effects models were used. MEASUREMENTS AND MAIN RESULTS: FEV1 and FVC were measured. @entity2 was defined as post-bronchodilator FEV1/FVC <0.7. Childhood wheezing phenotype was related to 1989, 1995, 2001, and 2014 spirometry data. Three hundred thirty subjects, mean age 61 years, were followed up: 38 with @entity1 ; 53 with childhood wheezy @entity3 ; and 239 control subjects (of whom 57 developed adulthood-onset wheeze between ages 16 and 46 yr). In adjusted multivariate analyses, @entity1 was associated with an increased risk of @entity2 (odds ratio, 6.37; 95% confidence interval, 3.73-10.94), as was childhood wheezy @entity3 (odd ratio 1.81; 95% confidence interval, 1.12-2.91). The @entity2 risk increased with @entity1 , and wheezy @entity3 was associated with reduced FEV1 that was evident by the fifth decade and not an accelerated rate of FEV1 decline. In contrast, adulthood-onset wheeze was associated with accelerated FEV1 decline. CONCLUSIONS: Childhood wheezy @entity3 and @entity1 are associated with an increased risk of @entity2 and reduced ventilatory function.

title: Outcomes of XXXX and @entity3 . A 50-Year Cohort Study.

answer: @entity1


abstract: BACKGROUND: Many older adults suffer from @entity3 which decreases their functional capacity and reduces quality of life. Health behaviours and self-care during @entity1 and @entity3 can exert an important influence on health outcomes. The aims of this study were to (a) understand how older adult Thai individuals seek appropriate treatment to self-manage their @entity3 , and (b) to identify factors that contribute to effective @entity2 self-management. METHODS: Qualitative interviews were conducted with 32 older adults living in villages in north-east Thailand. Observations were also conducted with consenting individuals. Most interviews were audio-recorded and transcripts were coded and analysed using a grounded theory approach. RESULTS: Six contextual determinants affected the way @entity0 choose to self-manage their @entity3 , including: priority accorded to @entity2 management; information and resource seeking skills; critical appraisal skills; access to @entity2 -related information; access to treatment; and satisfaction and preferences for practitioners. @entity0 used several strategies to inform and develop their self-management plans: accessing and responding to information, sourcing resources, trial and error, evaluating treatment and evaluating practitioners. CONCLUSIONS: Attempts to increase accessibility, affordability and acceptability of @entity2 treatment can promote @entity2 self-management in older Thais. These findings have important implications for health professionals and government organisations seeking to enhance the self-management of @entity2 and quality of life in this population.

title: A qualitative study of older adults seeking appropriate treatment to self-manage their XXXX in rural North-East Thailand.

answer: @entity3


abstract: Our objective was to assess if contrast-enhanced (CE) anal endosonography (AES) with @entity1 is useful in the diagnosis of @entity4 . A Bruel and Kjaer scanner with a 7.0-MHz transducer was used. After visualization of the fistula tract in non-contrast (NC) AES, @entity1 was introduced into the fistula tract through the external opening in 22 @entity0 with different types of @entity3 . Both CE and NC AES revealed 13 transsphincteric, 3 intersphincteric, 2 suprasphincteric and 4 ano-vaginal @entity2 . Simple tracts were found in 16 cases and complex in 6 cases in non-contrast AES. The CE AES revealed 19 simple and 3 complex @entity2 . Fifteen internal openings visible in NC AES were confirmed in CE AES in 6 cases, which additionally found 11 more internal openings. Surgery confirmed all types of @entity2 found in NC and CE AES; however, the latter two found 18 simple and 4 complex @entity2 , and 21 internal openings. Both NC and CE AES are able to correctly differentiate types of @entity3 and are of comparable value in differentiating simple from complex @entity2 , although a false-negative result was found in CE AES. In the preoperative assessment of the internal opening, CE AES is superior to NC AES.

title: Usefulness of XXXX enhancement in diagnosis of @entity4 .

answer: @entity1


abstract: The aim of this study was to analyse the changes of baroreflex sensitivity ( @entity2 ) and their relation to changes of heart rate and blood pressure in medical students during moderate @entity1 brought about by oral examination. The changes of @entity2 during the stress were compared with the changes during light physical exercise. Thirty three students were examined 30 min before and 30 min after the exam. Thirty-nine students of control group were examined at rest and during light exercise. Blood pressure was noninvasively recorded by @entity3  z method at rate-controlled breathing (0.33 Hz). The @entity2 [ms/mm Hg] and BRSf [Hz/mm Hg] were calculated by spectral analysis of spontaneous fluctuations of blood pressure and inter-beat intervals (IBI). @entity2 before examination (7.12 ms/mm Hg) was significantly lower than after the oral exam (8.77 ms/mm Hg, p<0.05). The difference between @entity2 in the test group after the oral exam and the control group at rest (10.78 ms/mm Hg) was not significant. @entity2 during light exercise (7.44 ms/mm Hg) corresponded to the value during @entity1 . The values of BRSf did not change during @entity1 (before: 0.0182 Hz/mm Hg; after: 0.0182 Hz/mm Hg) and exercise (rest: 0.0158 Hz/mm Hg; exercise: 0.0144 Hz/mm Hg). Correlation between @entity2 or BRSf and blood pressure were not found. A significant negative correlation (r=-0.404, p<0.05) between BRSf and the increase of diastolic blood pressure during stress was observed. It is concluded that BRSf remained constant during @entity1 and exercise, and differed essentially from that in @entity0 subjects.

title: Baroreflex sensitivity during XXXX .

answer: @entity1


abstract: BACKGROUND: In resource-limited nations like Nepal, @entity1 , including @entity3 ( @entity3 ), have great public health impact. @entity3 and a few other @entity1 can be prevented by micronutrient supplementation. Without proper research regarding such defects, it is difficult to assess the damage made to health and productivity. This study aims to investigate different @entity1 among @entity0 in Nepal. METHODS: Household surveys and health camps were conducted from 2011 to 2012. Physical examination of @entity0 of reproductive age (15 to 49  years) was done in selected Village Development Committees of nine districts in three ecological regions of Nepal. @entity1 , including @entity3 , were examined in @entity0 (age 0 to 5  years) who were alive at the time of the survey. Data entry and analysis was performed by using SPSS version 11.5. RESULTS: 21,111 @entity0 were interviewed and 27,201 @entity0 born to them were assessed. The prevalence of @entity1 was 52.0 (95  % CI: 44.0-61.0) per 10,000 @entity0 . The prevalence of selected @entity3 was 4.0 (95  % CI: 2.0-7.0) per 10,000 @entity0 . Among the @entity3 , @entity5 , myelomeningocele and dermal sinus were the major ones, having almost the same prevalence in the Hill and Terai regions. The majority of @entity0 with @entity4 (17.0 per 10,000 @entity0 ; 95  % CI: 10.0-28.0) and @entity6 (14.0 per 10,000 @entity0 ; 95  % CI: 8.0-24.0) were found in the Terai. The rate of @entity2 was higher in the regions where @entity0 were in poor health. CONCLUSION: There is high prevalence of @entity1 in Nepal. Since such defects add a burden to families and society, it is imperative that health policies addressing programs like supplementation, fortification and dietary diversification be implemented.

title: Prevalence of @entity1 including selected XXXX in Nepal: results from a health survey.

answer: @entity3


abstract: From May to November 2013, a total of 1175 wild freshwater fishes were collected from the rivers of Chuoer, Yalu, Wuyuer, Alun, and Yin in Nenjiang River basin Qiqihaer City, and examined for metacercariae by direct compression method. The metacercariae were collected by artificial digestion method. Forty Kunming @entity0 were infected with 30-40 metacercariae of @entity3 . The @entity0 were sacrificed 36 days after @entity1 , and the adult worms were collected from bile duct, and observed under microscope. The results showed that a total of 1 175 fishes, belonging to nine species were taken from the Nenjiang basin of Qiqihaer region. The @entity1 rate of @entity3 metacercariae was 51.2% (602/1 175). All the species were infected besides @entity6 , and the highest prevalence (82.7%, 91/149) was found in Longnose @entity7 and the lowest (7.1%, 6/84) in Perccottus glenii. Among the rivers, the highest prevalence of metacercariae was in Wuyuer River. (65.7%, 218/332), and the lowest was in Alun River and Yin River (24.1%, 67/278) (P<0.05). Each part of the body in the @entity2 and @entity5 were susceptible for metacercariae. The main @entity1 site in Longnose @entity7 was the fish scales, and @entity4 metacercaria was first discovered in the brain tissue of @entity8 . The experimental results showed that the adult worms of @entity4 were found in the hepatic bile duct of the @entity0 , with an @entity1 rate of 85.0% (34/40). The suckers, digestive system and reproductive system of @entity4 were visible clearly.

title: [Prevalence of metacercariae of XXXX in wild freshwater fishes from Nenjiang River around Qiqihaer City].

answer: @entity3


abstract: UNASSIGNED: Bacteriophages are the main cause of fermentation failures in dairy plants. The majority of @entity0 phages can be divided into either cos- or pac-type phages and are additionally characterized by examining the V2 region of their antireceptors. We screened a large number of @entity1 phages from the Chr. Hansen A/S collection, using PCR specific for the cos- or pac-type phages, as well as for the V2 antireceptor region. Three phages did not produce positive results with the assays. Analysis of phage morphologies indicated that two of these phages, CHPC577 and CHPC926, had shorter tails than the traditional @entity1 phages. The third phage, CHPC1151, had a tail size similar to those of the cos- or pac-type phages, but it displayed a different baseplate structure. Sequencing analysis revealed the genetic similarity of CHPC577 and CHPC926 with a subgroup of @entity2 P335 phages. Phage CHPC1151 was closely related to the atypical @entity4 , homologous with a nondairy streptococcal prophage. By testing adsorption of the related streptococcal and lactococcal phages to the surface of @entity1 and @entity3 strains, we revealed the possibility of cross-interactions. Our data indicated that the use of @entity1 together with @entity3 , extensively applied for dairy fermentations, triggered the recombination between phages infecting different bacterial species. A notable diversity among @entity1 phage populations requires that a new classification of the group be proposed.IMPORTANCEStreptococcus thermophilus is a component of thermophilic starter cultures commonly used for cheese and yogurt production. Characterizing streptococcal phages, understanding their genetic relationships, and studying their interactions with various hosts are the necessary steps for preventing and controlling phage attacks that occur during dairy fermentations.

title: Novel Variants of XXXX Bacteriophages Are Indicative of Genetic Recombination among Phages from Different Bacterial Species.

answer: @entity0


abstract: OBJECTIVES: This study was designed to assess prospectively changes in serum lipid profile and myocardial perfusion with serial radionuclide single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) during the first six months of pravastatin therapy. BACKGROUND: Morbid coronary events occur despite statin therapy and lipid-lowering in @entity0 with @entity2 ( @entity2 ). A reliable strategy to identify responders with effective treatment from nonresponders on statin therapy before clinical events is needed. METHODS: Rest and stress SPECT MPI and lipids were assessed serially in 25 @entity0 (36% @entity0 ) with @entity2 and @entity4 during the first six months of pravastatin therapy. RESULTS: Total @entity1 , low-density lipoprotein @entity1 , and @entity3 declined (26%, 32%, and 30%, respectively) by six weeks and remained reduced at six months. Mean stress perfusion defect (summed stress score [SSS]) was severe (13.3 +/- 6.0) at baseline, showed no change at six weeks, and improved significantly at six months (10.3 +/- 7.3, p < 0.01). The six-month study SSS improved in 11 (48%) @entity0 , was unchanged in 10 (43%) @entity0 , and worsened in 2 (9%) @entity0 . Changes in lipid levels did not reliably predict changes in myocardial perfusion at six weeks or six months in this small pilot study. CONCLUSIONS: Serial SPECT MPI demonstrated improved stress myocardial perfusion in 48% of @entity0 treated for six months with @entity5 . Time course of improved myocardial perfusion during pravastatin therapy is delayed compared to lipids. Direction and magnitude of changes in the myocardial perfusion vary and do not correlate closely with improvements in lipids.

title: Prospective serial evaluation of myocardial perfusion and lipids during the first six months of pravastatin therapy: XXXX regression single photon emission computed tomography monitoring trial.

answer: @entity2


abstract: OBJECTIVE: To evaluate the results of stereotactic radiosurgery treating @entity6 secondary to type 2 @entity5 . METHODS: A retrospective review of 122 type 2 @entity6 consecutively treated in 96 @entity0 . Tumour control was assessed by recourse to surgical intervention, by serial radiological imaging, and by the calculation of relative growth ratios in @entity0 (n=29) habouring untreated @entity1 to act as internal controls. Hearing function was assessed with Gardner-Robertson grades and with averaged pure tone audiogram thresholds. Other complications are detailed. RESULTS: Applying current techniques, eight years after radiosurgery it was estimated that 20% of @entity0 will have undergone surgery for their @entity1 , 50% will have radiologically controlled @entity1 , and in 30% there will be some variable concern about @entity1 control, but up to that time they will have been managed conservatively. Relative growth ratios one and two years after treatment indicate that radiosurgery confers a significant (p=0.01) advantage over the natural history of the disease. Analysis of these ratios beyond two years was precluded by the need to intervene and radiosurgically treat the contralateral control @entity1 in more than 50% of the cases. This growth control was achieved with 40% of @entity0 retaining their Gardner-Robertson hearing grades three years after treatment, (40% having some deterioration in grade, 20% becoming deaf). Pure tone audiogram results suggest some progressive long term @entity3 , although interpretation of this is difficult. @entity2 occurred in 5% and 2%. CONCLUSIONS: Radiosurgery is a valuable minimally invasive alternative treatment for these @entity1 . For most @entity0 , it controls growth or defers the need for surgery, or both. There is a price in terms of hearing function, although this may compare favourably with the @entity4 associated with the natural history of the disease, and with surgery. In deciding on therapy, @entity0 should be aware of this treatment option.

title: Clinical experience with gamma knife stereotactic radiosurgery in the management of XXXX secondary to type 2 @entity5 .

answer: @entity6


abstract: One of the best documented autosomal linkage associations in @entity0 is on chromosome 1p and in the @entity1 on chromosome 4. On mitotic chromosomes this genetic homology is shown more clearly by early replication banding (RBG; induced by incorporation of @entity3 ( @entity3 ) in the second half of the S phase) than by structural banding (induced on prefixed chromosomes by denaturation, RFA, or trypsin, @entity4 ). To analyse this phenomenon in more detail, 11 chromosomal regions in @entity0 and the @entity2 with known genetic homology were compared. In four chromosome pairs RBG and @entity4 banding show the same degree of homology. In seven chromosome pairs the homology is more pronounced by RBG than by @entity4 banding. RFA banding does not reveal the same extent of homology as does RBG banding. These results clearly show a difference between the structural banding pattern, RFA and @entity4 , and the replication banding pattern, RBG. The following conclusions can be drawn: in chromosomal regions with homologous functions the DNA replicates in the same temporal order. Early replication banding (RBG) reveals a functional pattern in these regions which has been more strongly preserved during evolution than the underlying chromosomal DNA. Differences in chromosomal banding are most prominent in the @entity4 banding pattern, whereas similarities are most apparent in the RBG banding pattern.

title: Early replication banding reveals a strongly conserved functional pattern in XXXX chromosomes.

answer: @entity0


abstract: INTRODUCTION: The aim of this study was to evaluate epicardial biventricular pacing as a means of maintaining synchronous ventricular activation in an acute @entity2 model of @entity5 with normal ventricular anatomy and function. Chronic single-site ventricular pacing results in dyssynchronous ventricular activation and may contribute to @entity1 . Biventricular pacing has been used successfully in adult @entity0 with @entity4 . METHODS AND RESULTS: This was an acute study of open chest mongrel @entity2 (n = 13). ECG, left ventricular (LV), aortic, and pulmonary arterial pressures were measured. LV impedance catheters were used to assess cardiodynamics using instantaneous LV @entity3 ( @entity3 ). Following radiofrequency ablation of the AV node, a temporary pacemaker was programmed 10 beats/min above the intrinsic atrial rate, with an AV interval similar to the baseline intrinsic PR interval. The pacing protocol consisted of 5-minute intervals with the following lead configurations: right atrium-right ventricular apex (RA-RVA), RA-LV apex (LVA), and RA-biventricular using combinations of four ventricular sites (RVA, RV outflow tract [RVOT], LVA, LV base [LVB]). RA-RVA was used as the experimental control. LV systolic mechanics, as measured by the slope of the end-systolic (Ees) @entity3 (ESPVR, mmHg/cc), was statistically greater (P < 0.05) with all modes of biventricular pacing (RA-RVA/LVA 20.0 +/- 2.9, RA-RVA/LVB 18.4 +/- 2.9, RA-RVOT/LVA 15.1 +/- 1.8, RA-RVOT/LVB 17.6 +/- 2.9) compared to single-site ventricular pacing (RA-RVA 12.8 +/- 1.6). Concurrent with this improvement in myocardial performance was a shortening of the QRS duration (RA-RVA 97.7 +/- 2.9 vs RA-RVA/LVA 75.7 +/- 4.9, RA-RVA/LVB 70.3 +/- 4.9, RA-RVOT/LVA 65.3 +/- 4.4, and RA-RVOT/LVB 76.7 +/- 5.9, P < 0.05). CONCLUSION: In this acute @entity2 model of @entity5 , QRS duration shortened and LV performance improved with epicardial biventricular pacing compared to standard single-site ventricular pacing.

title: Evaluation of myocardial performance with conventional single-site ventricular pacing and biventricular pacing in a XXXX model of @entity5 .

answer: @entity2


abstract: OBJECTIVE: To identify associations between @entity6 exposure during pregnancy and medical conditions in newborn @entity0 from birth through hospital discharge. DESIGN: Multisite, prospective, randomized study. SETTING: Brown University, University of Miami, University of Tennessee (Memphis), and Wayne State University. Subjects A total of 717 @entity6 -exposed @entity0 and 7442 nonexposed @entity0 . MAIN OUTCOME MEASURES: Results of physical examination and conditions observed during hospitalization. RESULTS: @entity6 -exposed @entity0 were about 1.2 weeks younger, weighed 536 g less, measured 2.6 cm shorter, and had head circumference 1.5 cm smaller than nonexposed @entity0 (all P<.001). Results did not confirm previously reported abnormalities. Central and autonomic nervous system symptoms were more frequent in the exposed group: jittery/ @entity4 (adjusted odds ratio, 2.17; 99% confidence interval, 1.44-3.29), high-pitched cry (2.44; 1.06-5.66), @entity2 (1.81; 1.18-2.80), excessive suck (3.58; 1.63-7.88), hyperalertness (7.78; 1.72-35.06), and autonomic instability (2.64; 1.17-5.95). No differences were detected in organ systems by ultrasound examination. Exposed @entity0 had more @entity3 (3.09; 1.76-5.45), including @entity1 (13.46; 7.46-24.29), syphilis (8.84; 3.74-20.88), and @entity0 @entity5 virus exposure (12.37; 2.20-69.51); were less often breastfed (0.26; 0.15-0.44); had more @entity0 protective services referrals (48.92; 28.77-83.20); and were more often not living with their biological mother (18.70; 10.53-33.20). CONCLUSIONS: Central and autonomic nervous system symptoms were more frequent in the exposed cohort and persisted in an adjusted analysis. They were usually transient and may be a true @entity6 effect. Abnormal anatomic outcomes previously reported were not confirmed. @entity3 , particularly sexually transmitted diseases, pose a serious public health challenge. Exposure increased involvement of @entity0 protective services and out-of-home placement.

title: Acute neonatal effects of XXXX exposure during pregnancy.

answer: @entity6


abstract: OBJECTIVE: Herein we report our experience in placement of endovascular stentgrafts in the descending aorta in @entity0 with @entity4 due to @entity2 or aortobronchial fistula. METHODS: Six @entity0 (one @entity0 , five @entity0 , mean age 47+/-19 years) were treated from September 1995 to February 2000 by implantation of endovascular stentgrafts in the descending aorta. Indications included traumatic @entity2 of the aortic isthmus (n=3) and aortobronchial @entity1 (n=3). All procedures were performed under general anaesthesia. The implants were introduced under fluoroscopic guidance via the aorta (n=1), the iliac (n=4) or femoral (n=2) artery, respectively. RESULTS: All aortobronchial @entity1 and @entity2 were sealed up successfully. There was no perioperative morbidity and no procedure-related morbidity except one @entity0 who received aortofemoral reconstruction because of @entity3 . All @entity0 are alive and well after a mean follow-up of 31 months (range 6-60). Two @entity0 had recurrent hemoptysis, in one case, the @entity0 received a second implant (distal extension), the other @entity0 was managed conservatively. CONCLUSION: Endovascular treatment by a stentgraft is a safe and reliable procedure in the management of @entity4 in @entity0 with @entity5 or aortobronchial @entity1 .

title: Endovascular treatment of XXXX in traumatic @entity5 .

answer: @entity4


abstract: OBJECTIVES: To identify a better set of DNA methylation markers to detect superficial, low grade @entity1 cell in urine sediment for improving @entity1 treatment, morbidity, and mortality. MATERIALS AND METHODS: Methylation-specific PCR (MSP) assay was used to detect promoter hypermethylation in 4 genes ( @entity4 , @entity3 , @entity3 , and @entity5 ) to identify reliable biomarkers for @entity2 diagnosis in @entity1 DNA and urine sediment DNA from 57 @entity2 @entity0 . Urine DNA was compared with 20 healthy controls. RESULTS: Fifty-one (90%) @entity1 DNA and 47 urine DNA (83%) samples from @entity2 @entity0 revealed hypermethylation in at least 1 of the 4 analyzed genes, whereas all urine samples from normal controls were negative. The sensitivity of MSP assay for detecting @entity4 , @entity3 , @entity3 and @entity5 in @entity1 cells in voided urine was 35%, 35%, 33%, and 65%, respectively. Diagnostic sensitivity was 75% for combining @entity5 and @entity3 , and 83% for @entity5 , @entity3 and @entity4 . Urine cytology, however, detect only 13 (28%) cases of @entity1 or suspicious @entity1 . For detecting superficial and invasive @entity2 , urine cytology revealed a sensitivity of 23% (6/26) and 35% (7/20), respectively. In contrast, MSP detected hypermethylation in the urine of 80% (37/46) @entity2 @entity0 . Moreover, hypermethylation analysis of @entity4 , @entity3 or @entity5 genes in urine sediment DNA detected in 85% (22/26) of superficial, 85% (11/13) of low grade, 75% (15/20) of invasive and 79% (26/33) of high grade @entity2 . Importantly, hypermethylation was detected in the urine DNA of 90% (18/20) superficial @entity1 with negative or atypia cytology. CONCLUSIONS: Hypermethylation of @entity4 , @entity3 or @entity5 in urine sediment DNA is a potential biomarker for detecting superficial, low grade @entity1 . Besides, hypermethylation of these 3 genes is a valuable adjunct diagnostic marker to urine cytology, which can enhance the diagnostic accuracy and follow-up treatment of @entity2 @entity0 .

title: Increase sensitivity in detecting superficial, low grade @entity2 by combination analysis of hypermethylation of @entity4 , @entity3 , XXXX , @entity5 genes in urine.

answer: @entity3


abstract: @entity3 (NO) functions as a cell-signaling molecule in plants. In particular, a role for NO in the regulation of @entity0 homeostasis and in the plant response to toxic metals has been proposed. Here, we investigated the synthesis and the role of NO in plants exposed to @entity8 ( @entity7 ), a nonessential and toxic metal. We demonstrate that @entity7 induces NO synthesis in roots and leaves of @entity4 ( @entity4 ) seedlings. This production, which is sensitive to NO synthase inhibitors, does not involve @entity5 reductase and @entity10 but requires @entity9 , encoding a major plasma membrane transporter for @entity0 but also @entity7 . By analyzing the incidence of NO scavenging or inhibition of its synthesis during @entity7 treatment, we demonstrated that NO contributes to @entity7 -triggered inhibition of root growth. To understand the mechanisms underlying this process, a microarray analysis was performed in order to identify NO-modulated root genes up- and down-regulated during @entity7 treatment. Forty-three genes were identified encoding proteins related to @entity0 homeostasis, proteolysis, @entity6 assimilation/metabolism, and root growth. These genes include @entity9 . Investigation of the metal and ion contents in @entity7 -treated roots in which NO synthesis was impaired indicates that @entity9 up-regulation by NO was consistently correlated to NO's ability to promote @entity7 accumulation in roots. This analysis also highlights that NO is responsible for @entity7 -induced inhibition of root @entity2 accumulation. Taken together, our results suggest that NO contributes to @entity7 @entity1 by favoring @entity7 versus @entity2 uptake and by initiating a cellular pathway resembling those activated upon @entity0 deprivation.

title: XXXX contributes to @entity8 @entity1 in @entity4 by promoting @entity8 accumulation in roots and by up-regulating genes related to @entity0 uptake.

answer: @entity3


abstract: BACKGROUND: Current treatment strategies for @entity2 are moving away from radical resection and toward surgical @entity1 reduction, in order to preserve function and reduce morbidity. Radiotherapy modalities are alternative primary treatment options. MATERIALS AND METHODS: A PubMed search of the relevant literature on genetics and treatment of @entity2 was conducted. RESULTS: The rapid progress made in genetic research was mainly triggered by two factors: firstly, the establishment of central registries for @entity3 @entity0 and secondly, the availability of next-generation sequencing methods. Exome sequencing and a gene-panel sequencing approach have already been successfully applied to @entity3 syndromes. The latter method in particular is rapid and cost-effective, and may soon replace complex genotyping algorithms. The literature provides good evidence that diversified modern treatment options are available to realize individual treatment concepts for almost all @entity3 manifestations. Generally, small and symptomatic @entity1 should be completely resected, particularly in younger @entity0 . Considering the @entity0 's age, symptoms, morbidity risk, and comorbidities, larger @entity1 should be surgically treated in a function-preserving manner. In these cases, primary radiotherapy is an equivalent alternative option. A "wait and scan" strategy is possible in selected cases. DISCUSSION: The potential morbidity of surgical treatment must be weighed against the expectable quality of life. Comprehensive consultation with the @entity0 about possible treatment modalities is mandatory. Treatment decision making should involve a multidisciplinary team of experts.

title: [Head and neck XXXX : An interdisciplinary challenge].

answer: @entity3


abstract: BACKGROUND: The muscle imbalance associated with the @entity2 type of @entity1 may result in @entity4 or dislocations of the hip. The aim of the study was to compare the clinical and radiological results of myotomy of the hip adductor muscles versus adductor transfer to the ischiadic tuber in the prevention of @entity3 in @entity1 . MATERIAL AND METHODS: The study involved 36 ambulant @entity0 with @entity2 treated at our Department in the years 1987-2002. Group I consisted of 21 @entity0 (41 @entity3 ) who underwent myotomy of the adductor longus, adductor brevis and gracilis muscles. Mean age at the time of surgery was 10 years (3 to 17 years). Group II consisted of 15 @entity0 (28 @entity3 ) who underwent transfer of the tendons of the adductor muscles to the ischiadic tuber. Mean age at the time of surgery in this group was 8 years (3 to 16 years). The mean duration of hospital stay was 6 days in Group I and 9 days in Group II. Rehabilitation was carried out for an average of 3 months in Group I and 4 months in Group II. RESULTS: The follow-up examination showed improvement in the hip range of motion in both groups and no radiographic differences. CONCLUSIONS: Adductor myotomy is superior to adductor transfer because of easier surgical technique, shorter duration of hospital stay and no need to immobilize the hip.

title: Evaluation of adductor myotomy versus adductor transfer to ischiadic tuber in the treatment of XXXX hip in @entity1 .

answer: @entity2


abstract: AIMS: To determine the risk of all cause mortality, cause specific mortality, and incident @entity1 in meatworkers. METHODS: In a retrospective cohort study, a list of members of a meatworkers union in Australia was matched with the national @entity3 and @entity1 registries. Standardised mortality ratios (SMR) and standardised incidence ratios (SIR) were calculated using Australian population rates. Exposure to animal viruses, animal blood, animal faeces, and plastic pyrolysis products was assigned according to job title. A nested case control analysis examined the risk of mortality and @entity1 incidence by each exposure. RESULTS: There were approximately 20 000 subjects available for analysis. Male workers had increased risk of mortality from all causes (SMR 116, 95% CI 105 to 128) and from injury (SMR 131, 95% CI 108 to 157). Risk of incident @entity0 in males was non-significantly increased (SIR 164, 95% CI 97 to 259) and males had a raised risk of @entity2 (SIR 188, 95% CI 103 to 315). There were no significant associations with specific exposures. CONCLUSIONS: Compared to the general Australian population, meatworkers have increased risk of @entity3 from all causes, @entity3 from injury, and incident lung and @entity2 . Analysis by occupational exposures did not disclose any strong evidence of specific occupational risk factors, although this analysis was limited by small numbers of some outcomes and exposure assessment which was based on job titles only.

title: Mortality and XXXX incidence in a cohort of meatworkers.

answer: @entity1


abstract: BACKGROUND: Idiopathic @entity6 ( @entity6 ) is characterized by @entity5 , resulting in motor activity during dreams. Studies estimate that approximately half of @entity0 with @entity6 will eventually develop @entity1 ( @entity1 ), so @entity6 may be an indicator of presymptomatic @entity1 . Several potential early diagnostic markers of @entity1 have been proposed, but they have generally not been tested in presymptomatic @entity1 . The authors hypothesized that these markers may be abnormal in idiopathic @entity6 . METHODS: The authors compared 25 @entity0 with polysomnography-confirmed @entity6 without @entity1 with age- and sex-matched controls. Color vision, olfaction, quantitative motor testing, and indices of @entity2 , @entity4 , and autonomic function were examined. RESULTS: @entity0 demonstrated significant impairment in color discrimination and olfactory function. @entity0 had @entity3 on quantitative testing of motor and gait speed. Autonomic symptoms were more common in @entity0 than controls. Abnormalities were heterogeneous, with some @entity0 scoring normally on all domains, whereas others were severely impaired on multiple domains. Dysfunction on tests of olfactory function, color vision, and motor speed were highly correlated, such that @entity0 who performed poorly on one test tended to perform poorly on the others. CONCLUSIONS: Many potential early markers of @entity1 are significantly abnormal in @entity6 . These abnormalities are present in approximately half of the @entity0 , suggesting a heterogenous pathophysiology.

title: Potential early markers of XXXX in @entity6 .

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity4 ) results in learning and @entity7 . @entity2 result from cellular and metabolic dysfunction after injury, including decreased cerebral @entity5 uptake and @entity0 . This study assessed the ability of intranasal insulin to increase cerebral @entity5 uptake after injury, reduce lesion volume, improve memory and learning function and reduce @entity0 . Adult male @entity1 received a controlled cortical impact (CCI) injury followed by intranasal insulin or saline treatment daily for 14 days. PET imaging of @entity6 uptake was performed at baseline and at 48   h and 10 days @entity3 and MRI on days three and nine post injury. Motor function was tested with the beam walking test. Memory function was assessed with Morris water maze. Intranasal insulin after CCI significantly improved several outcomes compared to saline. Insulin-treated animals performed better on beam walk and demonstrated significantly improved memory. A significant increase in @entity6 uptake was observed in the hippocampus. Intranasal insulin also resulted in a significant decrease in hippocampus lesion volume and significantly less microglial immunolabeling in the hippocampus. These data show that intranasal insulin improves memory, increases cerebral @entity5 uptake and decreases neuroinflammation and hippocampal lesion volume, and may therefore be a viable therapy for @entity4 .

title: Intranasal insulin treatment of an experimental model of moderate XXXX .

answer: @entity4


abstract: INTRODUCTION AND METHODS: The benefits of hormone replacement therapy (HRT) in postmenopausal @entity1 are well known including control of vasomotor symptoms and long-term benefits on the cardiovascular, skeletal and central nervous systems. However, some studies have reported a link between long-term HRT use and @entity2 . This paper reviews some of the data related to HRT and major gynaecological @entity2 . RESULTS: Appropriate HRT regimens can reduce the risk of @entity7 in non-hysterectomised @entity1 and can reduce the incidence of @entity3 . There is no consensus on a link between @entity4 , and the data relating to HRT and @entity0 presents differing risk analyses. However, it is generally accepted that HRT taken for 5 years or less does not increase the risk of @entity0 . When HRT is taken for 10 years or more, the relative risk of being diagnosed with @entity0 is 1.46. Individual risk must be weighed against the benefits offered by HRT, especially in terms of the long-term beneficial effects on the cardiovascular, skeletal and central nervous systems. Whilst one in 8-12 @entity1 may contract @entity0 in the western world, one in 3 @entity1 over 65 will have @entity5 and 30-50% of postmenopausal @entity1 will have @entity6 . CONCLUSION: Fear of @entity2 is one of the main reasons why @entity1 object to HRT. Physicians must be able to counteract this fear with fact, and counsel @entity1 on their individual risk, as well as putting any @entity2 risk into perspective with other long-term benefits.

title: HRT and XXXX risk: separating fact from fiction.

answer: @entity2


abstract: The objective of this study was to describe patterns and predictors of work absence in the prospective, community-based Maine Carpal Tunnel Study. Three hundred fifteen @entity0 with @entity2 ( @entity2 ) were recruited from physicians' offices throughout Maine. The @entity0 completed questionnaires at entry and after 6, 18, and 30 months. The questionnaires included scales measuring symptom severity, functional status, general and mental health status, exposure to physical stressors, work status, and other indicators. The analyses examined univariate and multivariate correlates of work absence. The mean age was 43, 72% of subjects were female, 71% underwent carpal tunnel release, and 45% were receiving Workers' Compensation. Fifty-two percent worked in managerial or technical occupations, 15% in service occupations, and 13% in heavy labor or machine operation. Forty-five percent of @entity0 changed jobs or were absent from work (aside from postoperative recovery) during the 30-month follow-up. In multivariate logistic regression models, correlates of work absence at 18 months included worse functional status of the hand at study entry and at 6-month follow-up, involvement of an attorney at the time of enrollment (P < 0.002 for each), and work absence at 6 months (P = 0.03). Worse upper extremity functional status and having a contested Workers' Compensation claim are critical predictors of work absence and should be principal targets of interventions to reduce @entity1 in @entity2 .

title: Prevalence and predictors of long-term XXXX due to @entity2 .

answer: @entity1


abstract: UNASSIGNED: @entity2 , occurring in advanced stages of @entity2 , is linked with poor prognosis and can cause invalidating symptoms. Physiopathological mechanisms of @entity6 formation are complex and have yet to be fully elucidated. In most cases, @entity6 is due to @entity5 in which vascular permeability is enhanced by @entity3 production while lymphatic drainage decreases. Ascites can also be secondary to portal @entity4 , for example in case of multiple liver @entity1 , or due to @entity9 . While paracentesis and diuretics are commonly used, their efficiency has never been compared in a randomized controlled study. Paracentesis brings immediate but temporary relief in over 90% of cases, and implies multiple hospitalizations. Literature reports @entity6 control by @entity7 alone or in association with @entity8 . But, available data is controversial, and there is no predictive factor to identify @entity0 that respond to diuretic treatment. The indication of diuretic treatment is left to the appreciation of physicians. Existing recommendations are old, and practices influenced by results obtained in non-neoplastic @entity6 . Additional evidences are required before guidelines can be established for the palliative management of @entity2 .

title: [Supportive care for XXXX in palliative phase: Place of paracentesis and diuretics].

answer: @entity2


abstract: BACKGROUND: Minimal @entity4 (MCNS) in @entity0 frequently is associated with @entity3 and immunoglobulin E production. T Helper subtype 2 cytokines, such as @entity5 ( @entity5 ), may have an important role in the development of @entity2 . We investigated the associations of gene polymorphisms of @entity9 ( @entity8 ), and the @entity6 ( @entity6 ) gene with MCNS. METHODS: We analyzed these polymorphisms in Japanese @entity0 with MCNS (n = 58) and healthy controls with neither allergic nor @entity1 (n = 63). The polymerase chain reaction (PCR) and restriction fragment length polymorphism method was used for the @entity5 promoter gene polymorphism ( @entity7 ), and PCR single-strand conformation polymorphism analysis was used for the @entity8 chain gene ( @entity10 ) and @entity6 3' untranslated region ( @entity11 ) polymorphisms. RESULTS: There was a significant difference between the MCNS group and controls in genotypic distribution of @entity5 promoter gene polymorphism. Frequency of the T allele was significantly lower in the MCNS group than controls. There was no difference between the MCNS group and controls in the @entity8 gene polymorphism. In the @entity6 gene, no significant differences in genotypic and allelic distribution were observed between the 2 groups. However, there were significant differences between @entity0 who did not need cytotoxic agents or who experienced 3 or fewer relapses and controls. CONCLUSION: These results suggest that genetic variations in the @entity5 and @entity6 genes may be associated with predisposition to MCNS, partially the clinical course of MCNS.

title: Polymorphisms of @entity5 --related genes in Japanese @entity0 with minimal XXXX .

answer: @entity4


abstract: The topography and spectral characteristics of @entity0 photoreceptors correlate with both, the present ecological demands and the evolutionary history. The South American Opossum is a marsupial @entity0 with unspecialized habitus and crepuscular lifestyle. A sparse population of cones (max. = 3000/ @entity1 ) can be differentiated into four subtypes by morphological, topographical and immunocytochemical criteria. In spite of this unusual diversity the cone types can be split into two functional groups: The population of single cones labeled by antibody OS-2 for short wavelength sensitive pigments was ubiquitous but at very low densities (200/ @entity1 ). The single cones labeled by antibody (COS-1) against long wavelength sensitive pigments constitute the dominant population in the area centralis (2300/ @entity1 ). These two single cone types correlate with the pair typically present in placental mammals. Discrimination of spatial and color contrast may be provided by this "modern" set. The COS-1 labeled double and single cones bearing an oil droplet, display a different pattern by being restricted to the inferior (non-tapetal) half of the retina (max = 800/ @entity1 ). This additional set of cones with oil droplets and long wavelength pigments is a conservative feature of the opossum retina and other marsupials. As an accessory cone system it is possibly providing enhanced sensitivity at mesopic conditions. During the early evolution of nocturnal mammals with its prominent expansion of rod vision these cone types were conserved but then were lost in placental mammals. Thus the unique features of @entity0 retinas are the result of two evolutionary steps: first a reduction of cone based vision, followed by a secondary differentiation of photopic vision and behaviour relying on the remaining set of cones.

title: The opossum photoreceptors--a model for evolutionary trends in early XXXX retina.

answer: @entity0


abstract: INTRODUCTION: Reconstruction after wide resection for a @entity4 involving the knee extensor mechanism is challenging even if the @entity1 is small. CASE DESCRIPTION: We report on four consecutive @entity6 treated similarly at a single institution. Histological diagnoses were @entity7 (two cases), clear cell @entity4 and extraskeletal @entity8 (one case each). Follow-up periods after surgery were 18-67  months. All cases underwent pre-operative radiotherapy and subsequent surgery. After preoperative radiotherapy and wide resection including the @entity2 tendon-bone allograft was fixed to the residual patella and tibial tuberosity with screws and a cable wire. Soft tissue and @entity5 over allograft was covered by free antero-lateral thigh flap. Post-operatively, the operated knee was splinted straight for at least 6 weeks, and then range-of-motion exercise was gradually introduced. Except for one case with a proximal tibial stress fracture 5  months post-operatively, no complication was observed. Both bone-bone junctions between allograft and residual bones were united within 1  year after surgery. At the latest clinical follow-up, all the @entity0 had satisfactory functions with @entity3 Society score of 28-30 out of 30 points and virtually full range of motion. DISCUSSION AND EVALUATION: This case series is the first to report bone-patellar tendon-bone allograft for reconstruction after @entity1 resection with joint preservation and with satisfactory clinical outcomes. CONCLUSIONS: Bone-patellar tendon-bone allograft reconstruction with vascularized flap reconstruction is a viable option for @entity6 .

title: Bone-patellar tendon-bone allograft reconstruction for XXXX : case series.

answer: @entity6