abstract: PURPOSE: Tumor relapse is the most frequent cause of @entity3 in stage 4 @entity4 . Since genomic information on the relapse precursor cells could guide targeted therapy, our aim was to find the most appropriate tissue for identifying relapse-seeding clones. EXPERIMENTAL DESIGN: We analyzed 10 geographically and temporally separated samples of a single @entity0 by SNP array and validated the data in 154 stage 4 @entity0 . RESULTS: In the case study, aberrations unique to certain tissues and time points were evident besides concordant aberrations shared by all samples. Diagnostic bone marrow-derived DTCs (disseminated @entity2 cells) as well as the @entity1 and DTCs at relapse displayed a 1q deletion, not detected in any of the seven primary @entity2 samples. In the validation cohort, the frequency of 1q deletion was 17.8%, 10%, and 27.5% in the diagnostic DTCs, diagnostic @entity2 , and DTCs at relapse, respectively. This aberration was significantly associated with 19q and @entity6 deletions. We observed a significant increased likelihood of an adverse event in the presence of 19q deletion in the diagnostic DTCs. CONCLUSIONS: Different frequencies of 1q and 19q deletions in the primary @entity2 as compared to DTCs, their relatively high frequency at relapse, and their effect on event-free survival (19q deletion) indicate the relevance of analyzing diagnostic DTCs. Our data support the hypothesis of a branched @entity5 and a parallel progression of primary and @entity1 cells. Therefore, searching for biomarkers to identify the relapse-seeding clone should involve diagnostic DTCs alongside the @entity2 tissue.

title: Impact of disseminated XXXX cells on the identification of the relapse-seeding clone.

answer: @entity4


abstract: STUDY DESIGN: Histologic documentation of vertebral bodies retrieved from @entity0 @entity0 . OBJECTIVES: The purpose of this study is to illustrate the histologic findings of two cases in which vertebroplasty and/or kyphoplasty had been performed. SUMMARY OF BACKGROUND DATA: There are a number of controversies to @entity4 , including the use of inflatable bone tamps, use of nonstandardized @entity5 ( @entity5 ) preparations, the extent and significance of thermal @entity1 , any @entity6 , and cement extravasation. METHODS: Four vertebral bodies from two cases ranging from 1 month to 2 years after surgery were analyzed histologically. @entity3 slides of retrieved vertebral bodies were reviewed with special reference for evidence of thermal @entity1 , @entity6 , migration of cement, cement voids and @entity2 , and for the influence of the bone tamp on adjacent bone. RESULTS: The cancellous bone around the cement of the kyphoplasty specimen showed good density, suggesting that the tamping had displaced bone, essentially autografting the space around the cement. Bone immediately around the cement did not show extensive @entity1 , but there were a few spicules of necrotic bone associated with creeping substitution, suggesting either thermal effect, the original @entity2 , or displacement of bone by the procedure. Foreign body giant cells and macrophages were identified in the fibrous membrane around the @entity5 in all segments. These cells contained material consistent with cement particles and/or @entity7 . Particles were also present within vascular spaces. CONCLUSIONS: To our knowledge, these cases are among the first published reports of @entity0 histology after vertebral cement augmentation and have implications concerning the nature of the surgical procedures as well as the material used for injection.

title: Histologic evaluation of XXXX vertebral bodies after @entity4 with @entity5 .

answer: @entity0


abstract: We examined the clonal evolution of skin malignant lesions by repeated topical applications of @entity9 (20-MC) to the skin, which induces @entity8 , @entity2 and @entity3 in @entity1 . The lesions were examined histologically and immunohistochemically with anti-single-stranded DNA after acid hydrolysis (DNA-instability test), @entity4 , @entity6 , @entity11 , @entity7 and AgNORs parameters analyses. Multiple clones with increased DNA instability comparable to that of @entity3 were noted in early-stage (2-6 weeks) @entity8 , and their number increased in middle (7-11 weeks), and late-stages (12-25 weeks) of @entity8 , indicating that they belong to the @entity0 category. All @entity3 showed a positive DNA-instability test. Positive immunostaining for various biomarkers and AgNORs parameters appeared in clones with a positive DNA-instability test in early-or middle-stage @entity8 , and markedly increased in late-stage @entity8 , @entity3 . The percentage of @entity7 -positive vascular endothelial cells was significantly higher in @entity6 -positive lesions with a positive DNA-instability test and became higher toward the late-stage of progression. Cut-woundings were made to @entity3 lesions, and the regeneration activity of vascular endothelial cells was determined by using flash labeling with tritiated @entity5 (3H-TdR). In small @entity2 , vascular endothelial cells showed regenerative response, but the response was weak in large lesions. No such response was noted in invasive @entity3 ; rather, cut-wounding induced collapse of blood vessels, which in turn induced @entity10 of @entity0 cells. These responses can be interpreted to reflect exhausted vascular growth activity due to excessive stimulation by @entity6 -overexpression, which was persistently seen from @entity8 to @entity3 .

title: Clonal evolution and progression of @entity9 -induced squamous cell carcinoma of @entity1 epidermis as revealed by DNA instability and other XXXX markers.

answer: @entity0


abstract: AIMS: The aim of this study was to characterise the @entity1 of @entity0 from @entity2 in New South Wales (NSW) over the last 10 years and ascertain whether there were modifiable factors that could have prevented the @entity1 . METHODS: The hospital medical records, coronial reports, immunisation records and all relevant correspondence from general practitioners, medical specialists and hospitals were reviewed for @entity0 who died with @entity2 in the 10 years (2004-2013). RESULTS: In 10 years, there were 20 @entity1 (0-7 per year) with a male predominance (70%) occurring in @entity0 aged 4-17 years. Sixteen (80%) had persistent @entity2 and 4 (20%) had intermittent @entity2 . The majority (55%) had been hospitalised for @entity2 in the preceding 12 months, 25% in the preceding 6 weeks. The majority (55%) was aged 10-14 years. Ninety percent were @entity3 . Psychosocial issues were identified in the majority (55%) of families. Forty percent had a @entity0 protection history. Seventy-five percent had consulted a general practitioner in the year before their death, 45% had a current written @entity2 action plan and 50% had not seen a paediatrician ever in relation to their @entity2 . Of the 16 @entity0 at school, the schools were aware of the @entity2 in 14 (88%) cases, but only half had copies of written @entity2 plans. CONCLUSIONS: Improved communication and oversight between health-care providers, education and community protection agencies could reduce mortality from @entity2 in @entity0 .

title: XXXX in @entity0 in New South Wales 2004-2013: Could we have done more?

answer: @entity1


abstract: AIMS: To study the expression and prognostic significance of the cell adhesion molecule @entity5 in oesophageal @entity1 from the UK (low risk area) and China (high risk area). METHODS: @entity5 expression was measured immunohistochemically in resected @entity1 from 17 @entity0 in the UK with @entity3 , 23 @entity0 from the UK with @entity4 , and 30 @entity0 from China with @entity4 who survived for five years postoperatively and compared with similar @entity1 from @entity0 in the same regions who did not survive (140 @entity1 in all). RESULTS: Normal squamous epithelial cells and well differentiated areas of @entity1 showed membranous staining for @entity5 expression. Cytoplasmic staining, heterogeneous staining, or an absence of staining was seen in @entity6 and in less well differentiated areas of @entity1 . Only one of 140 primary @entity1 had homogeneous membranous expression. In @entity1 from UK @entity0 with @entity3 (p = 1.00) and from Chinese @entity0 with @entity4 (p = 0.06) there was no correlation between @entity5 absence and non-survival. In @entity1 from UK @entity0 with @entity4 there was a significant correlation between absence of @entity5 and non-survival (p = 0.009). Tumours from UK @entity0 with @entity4 who survived were significantly less likely to be @entity5 absent than those from Chinese @entity0 with @entity4 who survived (p = 0.007). Multivariate analysis (n = 37 UK, paired data) showed that absence of @entity5 in the primary @entity1 was a weak independent prognostic factor for non-survival (30% significance level; p = 0.26; odds ratio = 3.56). In UK nodal metastases there was no correlation between @entity5 expression and survival. CONCLUSIONS: @entity4 from UK @entity0 differed from both @entity3 from UK @entity0 and @entity2 from Chinese @entity0 with respect to @entity5 expression and prognostic significance. In @entity1 from UK @entity0 , @entity5 absence in the @entity2 (a weak independent prognostic factor) but not metastases correlated with non-survival.

title: Expression of XXXX in oesophageal @entity2 from the UK and China: disparities in prognostic significance.

answer: @entity5


abstract: BACKGROUND: We tested the hypothesis that @entity3 , as defined by thyroid-stimulating hormone (TSH) concentration, is associated with a severity-weighted composite of mortality and major @entity1 after noncardiac surgery. METHODS: In this retrospective cohort study, we evaluated adults at the Cleveland Clinic Main Campus between 2005 and 2012, who had had available TSH concentrations within the 6 months before noncardiac surgery. @entity0 were categorized as (1) @entity3 ( @entity0 who had diagnosis of @entity3 any time prior to surgery and increased TSH value (> 5.5 mIU/L) within 6 months prior to surgery); (2) treated ( @entity3 diagnosis and normal TSH concentrations [0.4-5.5 mIU/L]); and (3) euthyroid (no @entity3 diagnosis and normal TSH concentrations). We conducted pairwise comparisons among the 3 groups using inverse propensity score weighting to control for observed confounding variables. Average relative effect generalized estimating equation model was used for the primary outcome composite of in-hospital @entity1 , surgical wound complication or @entity2 , and mortality. Logistic regression and Cox proportional hazards regression were used for secondary outcomes of intraoperative vasopressor use and duration of hospitalization, respectively. RESULTS: We identified 800 @entity3 @entity0 (median TSH: 8.6 mIU/L [Q1, Q3: 6.5, 13.0]), 1805 treated @entity0 (2.0 mIU/L [1.1, 3.2]), and 5612 euthyroid @entity0 (1.7 mIU/L [1.1, 2.6]). There were no significant differences among the @entity3 , treated, and euthyroid @entity0 on the primary composite outcome (all P values >= 0.30). @entity3 @entity0 were slightly more likely to receive vasopressor during surgery than either treated (odds ratio, 1.17; 99.2% confidence interval [CI], 1.01-1.36) or euthyroid (odds ratio, 1.12; 99.2% CI, 1.02-1.24) @entity0 . Furthermore, @entity3 @entity0 were slightly but significantly less likely to be discharged at any given postoperative time than treated @entity0 (hazard ratio, 0.92; 99.2% CI, 0.86-0.99). CONCLUSIONS: @entity3 was not associated with worse postoperative mortality, wound, or cardiovascular outcomes in noncardiac @entity0 . Thus, postponing surgery to initiate thyroid replacement therapy in @entity0 with @entity3 seems unnecessary.

title: The Effect of XXXX on a Composite of Mortality, @entity1 After Noncardiac Surgery: A Retrospective Cohort Analysis.

answer: @entity3


abstract: The occurrence of reduced @entity3 ( @entity3 ) among adolescent @entity0 with @entity14 or secondary @entity13 , due to 'pure' dysfunction of the hypothalamo- @entity1 (without @entity6 nervosa, excessive sport or ballet, slimming diet, etc.) was examined. The study group consisted of 19 adolescent @entity0 (age 16-18 years) with oligo/ @entity13 . Clinical (height, weight, age at menarche, duration of @entity13 , body mass index (BMI)), hormonal (follicle stimulating hormone (FSH), luteinizing hormone (LH), @entity2 , @entity11 , @entity5 , prolactin), and ion ( @entity7 , @entity9 , @entity8 , @entity10 , @entity15 ) parameters and the @entity3 of the lumbar spine were investigated. Correlations between @entity3 and other parameters were also examined. Twenty healthy volunteers (same age and regular cycles) served as controls. Three @entity0 had @entity4 , with a @entity3 below -2 standard deviations (SD). Ten showed @entity12 , with a @entity3 value between -1 and -2 SD. Only six of the study group had a normal @entity3 within +/- 1 SD. A positive correlation was observed between the @entity3 and the BMI (r = 0.73; p < 0.05). All the controls had normal hormonal, ion and @entity3 parameters. 'Pure' dysfunction of the @entity1 in adolescents, causing @entity14 or secondary @entity13 , might result in reduced @entity3 and, consequently, lower peak bone mass. Treatment of menstrual cycle disorders is necessary for the prevention of @entity4 .

title: Occurrence of @entity12 among adolescent XXXX with oligo/ @entity13 .

answer: @entity0


abstract: OBJECTIVE: @entity0 presenting with poor-grade @entity2 ( @entity2 ) have commonly been reported to have a poor prognosis; however, several reports suggest a favorable outcome in a subgroup of @entity0 . We analyzed our database to identify factors determining functional outcome after poor-grade @entity2 . METHODS: During the period 2004-2014, 248 @entity0 with poor-grade @entity2 were treated in our institution. Poor-grade @entity2 was defined as World Federation of Neurological Surgeons grades IV-V on admission. Data including @entity0 characteristics, treatment modality, radiologic features, and functional neurologic outcome were assessed and further analyzed. Outcome was assessed according to the modified Rankin Scale after 6 months and stratified into favorable (modified Rankin Scale score 0-2) versus unfavorable (modified Rankin Scale score 3-6). A multivariate analysis was performed to identify predictors of functional outcome. RESULTS: A favorable outcome was achieved in 24% of @entity0 with poor-grade @entity2 . @entity0 with a favorable outcome were significantly younger (P  = 0.005), harbored significantly smaller @entity1 (P  = 0.004), and had a lower initial World Federation of Neurological Surgeons grade (P < 0.0001). An unfavorable outcome was significantly more frequent in @entity0 with additional space-occupying @entity3 compared with @entity0 without additional space-occupying @entity3 (P  = 0.0009). On multivariate analysis, @entity0 age, World Federation of Neurological Surgeons grade V, signs of @entity4 , @entity1 size, and presence of space-occupying @entity3 were identified as significant predictors of unfavorable outcome in @entity0 with poor-grade @entity2 . CONCLUSIONS: A favorable outcome was achieved in 24% of severely ill @entity0 with poor-grade @entity2 . Therefore, treatment of @entity0 with poor-grade @entity2 should not be omitted. Careful individualized decision making is necessary for each @entity0 .

title: Poor-Grade XXXX : Factors Influencing Functional Outcome-A Single-Center Series.

answer: @entity2


abstract: OBJECTIVE: The objective of our study was to describe the national rates of surgery for @entity1 in @entity0 . STUDY DESIGN: We used the National Hospital Discharge Survey, a federal database that samples inpatient hospitals in the United States. Data from 1979 to 1997 were analyzed for diagnoses and procedures coded by using the International Classification of Diseases, 9th revision, Clinical Modification, classification system. Age-adjusted rates were calculated by using the 1990 census population and compared for change over time with the score test for linear trend. RESULTS: The number of @entity0 undergoing inpatient surgery for @entity1 has varied from 33000 in 1979 to 85000 in 1993. The rate of surgeries for @entity1 has almost doubled, from 0.32 procedures per 1000 @entity0 per year in 1979 to 0.60 procedures per 1000 @entity0 per year in 1997 (P =.02). The number of suprapubic slings performed increased over time. Approximately 2100 slings were performed per year until 1996, when 7348 were performed, followed by 10,192 in 1997 (rate increase from 12 to 75.2 per 1000000 @entity0 per year, P =.03). @entity0 undergoing @entity1 procedures were 79% white, 3% African American, and the remaining 18% other (including unknown). Thirty-seven percent of cases were performed in the South, 25% in the Midwest and West, and 12% in the Northeast. From 1979 to 1997, the mean age of @entity0 at the time of surgery increased from 50.5 +/- 12.1 years to 56.6 +/- 13.3 years; mean length of hospital stay decreased from 9.9 +/- 4.5 days to 2.7 +/- 1.4 days (P <.001). CONCLUSION: The rate of surgery for @entity1 in @entity0 has nearly doubled from 1979 to 1997.

title: Procedures for XXXX in the United States, 1979-1997.

answer: @entity1


abstract: PURPOSE: To evaluate the efficacy of medium-dose UVA1 phototherapy in @entity0 with @entity3 . METHOD: A controlled pilot study with medium-dose UVA1 (48 J/cm2) was performed. The results were evaluated by means of a skin score and two objective methods for quantifying @entity2 (cutometer and fast Fourier transform method). @entity0 were treated 4 times a week for 5 weeks. The follow-up period was 12 weeks. RESULTS: All @entity0 responded to therapy. Skin score and cutometer results showed improvement of skin elasticity of treated skin compared to control skin. Fast Fourier transform measurements showed no change in bundle orientation ratio and spacing. CONCLUSION: We concluded that treatment for 12 weeks 4 times a week with medium-dose UVA1 may be a beneficial therapy and a well-tolerated treatment modality for @entity3 ( @entity3 ). After 12 weeks, improvement of @entity1 can be detected by skin score and cutometer measurements but not by the fast Fourier transform method.

title: Evaluation of medium-dose UVA1 phototherapy in XXXX with the cutometer and fast Fourier transform method.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) has the highest lifetime treatment costs per @entity0 of all @entity1 . The objective of this study was to characterize the use of health-care services and costs associated with @entity2 among @entity0 who underwent radical cystectomy (RC) in the province of Quebec. METHODS: We conducted a descriptive study in a retrospective cohort of @entity0 who underwent RC for @entity2 between 2000 and 2009. Data was obtained from two health administrative databases (RAMQ and ISQ). We calculated average costs per @entity0 and total costs in 2014 Canadian dollars for the following components of costs: 1) Pre-surgery costs (pre and post-urologist consultations, urologist consultations, cystoscopies, TURBTs, imaging procedures); 2) Costs of radical cystectomy and 3) Post-surgery costs (urologist consultations, post-operative consultations, medical oncologist consultations, imaging procedures and post-operative complication management). ARIMA models were used to evaluate trends in average costs per @entity0 over the study period. RESULTS: Among 2759 @entity0 included in the study (75  % @entity0 ), average pre-surgery costs, RC costs, and post-surgery costs were estimated at 3762 , 18979  and 4770 , respectively. RC cost was responsible for 69  % of total costs, followed by post-operative consultations (7.8  %), post-operative complications and TURBTs (6  % of total costs, each). Academic hospitals performed RC at a lower average cost, compared to community hospitals (difference of  1000, p   <   .0001). A decreased trend in post-surgery costs was detected in the year 2009. CONCLUSIONS: Costs of RC, TURBT, consultations and post-operative complications were the most important economic components of total RC cost per @entity0 in Quebec. Academic hospitals performed RC at a lower cost, compared to community hospitals.

title: Health-care services utilization and costs associated with radical cystectomy for XXXX : a descriptive population-based study in the province of Quebec, Canada.

answer: @entity2


abstract: BACKGROUND: Results of the prognosis of @entity1 are conflictive and prevent an effective risk stratification. These conflicts are explained in part by insufficient consideration of methodological principles for prognostic research. This cohort study is aimed at identifying clinical predictors for risk stratification while paying particular attention to methodology. METHODS: We studied 120 @entity0 with @entity1 . Baseline data were extracted at the time of diagnostic renal biopsy, and @entity0 were followed prospectively. Predictors were identified for the end points @entity3 ( @entity3 ) and @entity3 or @entity2 . RESULTS: From the 120 @entity0 followed for a median of five years (1 to 24 years), 19% developed @entity3 or deterioration of renal function. @entity4 of more than 3.5 g/day persisted in 34%, and 47% were in complete or partial remission. The Kaplan-Meier estimated probability of renal survival was 91 +/- 3% at five years and 75 +/- 6% at ten years. The predictors for the primary outcome, @entity3 , identified in a Cox proportional hazards model, were histological stage (Ehrenreich-Churg) III-IV (hazard ratio 5.3, CI 1.9 to 15.0, P = 0.002) and @entity5 (hazard ratio 7.9, CI 1.1 to 61.5, P = 0.04); the predictors for the secondary outcome, @entity3 or @entity0 @entity2 , were histological stage III-IV (hazard ratio 2.8, CI 1.3 to 6.0, P = 0.008), @entity5 (hazard ratio 3.0, CI 1.1 to 8.0, P = 0.003) and comorbidity (hazard ratio 2.8, CI 1.3 to 5.9, P = 0.007). @entity5 and histological stage III-IV allowed the demarcation of the high-risk group from the remaining @entity0 (P < 0.0001). CONCLUSION: Histological stage, @entity5 , and comorbidity predict @entity3 or @entity2 in @entity1 . Identification of the high-risk group at the time of diagnostic renal biopsy will permit appropriate treatment to be targeted to the @entity0 who might benefit the most from the therapy in future clinical trials.

title: Prediction in XXXX .

answer: @entity1


abstract: Genomes can be markedly heterogeneous in conspecific bacterial strains. Genome sequences can be used to analyze genome plasticity via a PCR(2) (plasticity of chromosome revealed by PCR) approach. Small-sized chromosomes can indeed be fully amplified by long-range PCR with a set of primers designed using a reference strain and then applied to several other strains. Analysis of the resulting patterns can reveal genome plasticity. GenoFrag, a software package for the design of primers optimized for PCR(2) [N. Ben Zakour, M. Gautier, R. Andonov, D. Lavenier, M.F. Cochet, P. Veber, A. Sorokin, Y. Le Loir, GenoFrag: Software to design primers optimized for whole genome scanning by long-range PCR amplification, Nucleic Acids Res. 32 (2004) 17-24] was developed for the analysis of bacterial genome plasticity by whole genome amplification in approximately 10-kb-long fragments. By applying GenoFrag, we provide herewith evidence that genome plasticity can be analyzed in @entity0 bacteria using a PCR(2) approach. The genome sequences of @entity3 IL1403, @entity2 , @entity1 @entity1 and @entity4 were used to design four sets of primers. Each set was evaluated in silico to check that it ensured optimum coverage of the bacterial chromosome. To validate the primers generated by GenoFrag, a subset of primers was successfully used in LR-PCR experiments on genomic DNA from four @entity1 strains.

title: Testing of a whole genome PCR scanning approach to identify genomic variability in four different species of XXXX bacteria.

answer: @entity0


abstract: UNASSIGNED: 396 Background: The International mRCC Database Consortium (IMDC) Prognostic Model (Heng, et al. model, JCO, 2009) was defined and validated in a @entity0 cohort that was comprised of @entity3 of all histological-subtypes. Clear-cell @entity3 (ccRCC) accounts for ~80% of @entity3 cases, and thus it is unknown if this model is reliable in @entity0 with non-ccRCC (nccRCC). Therefore, we sought to evaluate the reliability of the model separately in ccRCC and nccRCC. METHODS: Data on 2,215 (1,963 ccRCC/252 n-ccRCC) @entity0 treated with 1-st line VEGF-and @entity4 targeted therapies were collected from the IMDC. nccRCC included papillary, chromophobe, and other histologies. @entity0 were assigned to favorable, intermediate, and poor prognosis groups according to the ICDM prognostic model. The discrimination ability for @entity2 ( @entity2 ) was evaluated by C-index. RESULTS: The median @entity2 of the entire cohort was 20.9 months. nccRCC @entity0 were of younger age (p < 0.0001), more often presented with low Hb (p = 0.014) and elevated neutrophils (p = 0.0001), but displayed otherwise similar clinicopathological features compared to ccRCC. @entity2 (22.3 vs. 12.8 months; p < 0.0001), and TTF (7.8 vs. 4.2 months; p < 0.0001) were worse in nccRCC compared to ccRCC. The hazard ratio for @entity1 ( @entity2 ) and treatment failure (TTF) when adjusted for the prognostic factors was 1.41 (95%CI 1.19, 1.67, p < 0.0001) and 1.54 (95% CI 1.33, 1.79, p < 0.0001), respectively. The IMDC prognostic model reliably discriminated three risk groups to predict @entity2 and TTF in nccRCC; the median @entity2 and TTF of favorable, intermediate, and poor prognosis groups were 31.4, 16.1, and 5.1 months (p < 0.0001) and 9.6, 4.9, and 2.1 months (p < 0.0001), respectively. The C-indices for @entity2 were 0.66 and 0.64 for the IDCM and MSKCC criteria, respectively. CONCLUSIONS: @entity0 with nccRCC treated with targeted therapies have a significantly worse outcome than ccRCC @entity0 . The IMDC prognostic model reliably predicts @entity2 and TTF in nccRCC and ccRCC.

title: Metastatic non-clear cell XXXX (nccRCC) treated with targeted therapy agents: Applying the International @entity3 Database Consortium (IMDC) prognostic model to predict outcomes.

answer: @entity3


abstract: BACKGROUND: @entity3 incidence rates are low in Asia and Africa and high in North America and Northern Europe. @entity0 is often the most common female @entity0 in developing countries, and @entity1 with @entity2 ) is its main risk factor. However, other factors, such as occupational exposures may modify the HPV-related risk. We conducted an exploratory register-linkage study in Finland to assess the role of occupational exposures on incidence rates of @entity0 of the endometrium and cervix uteri. METHODS: Occupational risk factors for @entity3 were explored in a 25-year follow-up of female workers born 1906-1945 (N = 413,877) identified through the Population Census of Finland of 1970. Job titles in census records were converted to exposures of 31 occupational agents through a job-exposure matrix. Poisson regression models estimated relative risks (RR) for each agent, standardized for birth cohort, follow-up period, and socio-economic status. For each agent, the product of level and probability of exposure was calculated and subdivided in three categories: zero, low, and medium/high. Adjustment at the job title level was done for the turnover rate ( @entity3 ), mean parity, and age at first birth ( @entity3 ). RESULTS: @entity3 (2,833 cases) was associated with exposure to animal dust (RR 1.2, low level, 174 cases) and sedentary work (RR 1.3, high level, 145 cases). @entity0 (1,101 cases) was associated with exposure to aliphatic and alicyclic (RR 1.3, low level, 91 cases), aromatic (RR 1.2, low level, 318 cases; RR 1.4, high level, 41 cases), and chlorinated @entity5 solvents (RR 1.3, low level, 50 cases), @entity4 dust (RR 1.2, low level, 251 cases), and wood dust (RR 1.2, low level, 249 cases). CONCLUSIONS: This study suggests that occupational exposures may be associated with increased risk of @entity3 .

title: Occupational exposures and XXXX of the endometrium and cervix uteri in Finland.

answer: @entity0


abstract: BACKGROUND: @entity9 antagonists are effective in the prevention and treatment of @entity6 . @entity7 is one of the most widely prescribed @entity9 antagonists in the world [1, 2]. It has a narrow therapeutic range and a given dose may result in a large inter-individual variation of response. Insufficient dose may fail to prevent @entity6 , while an @entity8 increases the risk of @entity3 . @entity0 -specific factors (e.g., age, body size, race, concurrent diseases, and medications) explain some of the variability in @entity7 dosage, but genetic factors influencing @entity7 response explain a significantly higher proportion of this variability [3]. Molecular analysis of the gene that encodes the target enzyme @entity12 reductase complex 1 ( @entity10 ) strongly suggests that its genetic variations greatly affect the individual response to oral anticoagulants [4-7]. OBJECTIVE: To evaluate effects of @entity10 polymorphisms on @entity7 dose excess anticoagulation (INR >4.0) in the population of Sakha (S) @entity0 . METHODS: 53 @entity0 (29- @entity0 , 24- @entity0 ) with @entity5 (68%), @entity4 (60%), @entity1 (49%) and @entity2 (26%) were recruited. The age range was 26-80 years, with a mean age of 62.87    12.57 years.International normalized ratio and plasma @entity7 concentrations were determined. Genotyping was carried out by RT-PCR (real-time PCR). The three genetic polymorphisms of the gene @entity10 @entity14 ( @entity13 ) were studied: normal (GG), heterozygous (GA) and homozygous ( @entity11 ). Fisher exact probability test and chi-square test (with Yates correction) were applied to compare data among the @entity11 and GG + GA groups; also Mann-Whitney test was used. RESULTS: The median maintenance daily dose of @entity7 among @entity11 carriers was 3.0 mg/day [1.25-7.5 mg], while in GG and GA @entity0 it was 3.13 mg/day [1.88-7.92 mg]. The mean daily @entity7 dosage was higher in GG and GA genotype carriers 4.05 mg/day (SD    1.7) than in @entity0 with @entity11 genotype 3.13 (SD    1.5). Differences are of borderline significance (p = 0.054). Of the 41 @entity0 who required @entity7 doses of less than 5 mg, 28 (63%) were found to be @entity11 carriers and 14 (37%) were GG, GA carriers. Differences were not quite significant (p = 0.072). Among 31 homozygous polymorphism carriers 2 (4%) @entity0 developed overanticoagulation (INR >4.0), while among 22 normal and heterozygous polymorphisms carriers only 3 (6%) @entity0 developed overanticoagulation (INR >4.0). Differences were not statistically significant (p = 0.36). CONCLUSIONS: No significant association between @entity10 polymorphisms and the frequency of excess anticoagulation (INR >4.0) was found. This may be explained by the number of cases included. @entity11 polymorphisms compared to other polymorphisms shows borderline difference in the @entity7 dose. The results can be used for the development of a pharmacogenetic-guided @entity7 dosing algorithm.

title: XXXX polymorphisms and @entity7 maintenance dose in population of Sakha (Yakuts).

answer: @entity10


abstract: The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a @entity0 model of antigen-induced airways @entity1 that involves intraperitoneal sensitization with @entity10 (OVA)/adjuvant followed by antigen aerosolization. We investigated the @entity6 and T-cell compartments both after sensitization (primary immune response) and after challenge (secondary immune response) at the thoracic lymph nodes (initiation site) and the lung (effector site). Our findings document a major cellular expansion in the lymph nodes after both sensitization and challenge. After sensitization, this expansion was comprised mainly of B cells, a considerable proportion of which expressed B7.2. At this time, T cells were markedly expanded and activated as assessed by @entity14 expression; further, although @entity11 and @entity9 were expressed at this time point, expression of @entity2 , @entity3 , and @entity5 messenger RNA (mRNA) levels were marginal. However, in vitro stimulation of lymph-node cells with OVA led to cytokine production. In contrast, 24 h after challenge, but not after sensitization, there was a major expansion of dendritic cells and macrophages in the lungs. This expansion was associated with enhanced expression of both @entity12 . We also observed expansion of activated @entity8 (+)/ @entity7 (+) T cells expressing the T helper-2-associated marker T1/ @entity13 in the lung, most notably 5 d after challenge. Further, @entity2 , @entity3 , and @entity5 , but not @entity4 mRNA were expressed at high levels 3 h after challenge. This study helps to elucidate the "geography" of immune responses generated in a conventional @entity0 model of @entity1 .

title: Temporal-spatial analysis of the immune response in a XXXX model of @entity10 -induced airways @entity1 .

answer: @entity0


abstract: PURPOSE: We evaluated sociodemographic and economic differences in @entity3 ( @entity3 ) of @entity0 with penile SCC using the National @entity1 Data Base (NCDB). METHODS: We identified 5,412 @entity0 with a diagnosis of @entity2 from 1998 to 2011 with clinically nonmetastatic disease and available pathologic @entity1 and nodal staging. @entity3 was estimated using the Kaplan-Meier method, and differences were determined using the log-rank test. Cox proportional hazard regression was performed to identify independent predictors of @entity3 . RESULTS: Estimated median @entity3 was 91.9 months (interquartile range: 25.8-not reached) at median follow-up of 44.7 months (interquartile range: 17.2-81.0). Survival did not change over the study period (P = 0.28). Black @entity0 presented with a higher stage of disease (pT3/T4: 16.6 vs. 13.2%, P = 0.027) and had worse median @entity3 (68.6 vs. 93.7 months, P<0.01). @entity0 with private insurance and median income>=  63,000 based on @entity4 code presented with a lower stage of disease (pT3/T4: 11.6 vs. 14.7%, P = 0.002 and 12.0 vs. 14.0%, P = 0.042, respectively) and had better median @entity3 (163.2 vs. 70.8 months, P<0.01 and 105.3 vs. 86.4 months, p = 0.001, respectively). On multivariate analysis, black race (hazard ratio [HR]: 1.39, 95% confidence interval [CI]: 1.21-1.58; P<0.01) was independently associated with worse @entity3 , whereas private insurance (HR = 0.79, 95% CI: 0.63-0.98; P = 0.028) and higher median income>=  63,000 (HR = 0.82; 95% CI: 0.72-0.93; P = 0.001) were independently associated with better @entity3 . CONCLUSIONS: Racial and economic differences in the survival of @entity0 with @entity1 exist. An understanding of these differences may help minimize disparities in @entity1 care.

title: Racial and economic disparities in the treatment of @entity2 : Results from the National XXXX Database.

answer: @entity1


abstract: THE OBJECTIVE OF THIS STUDY was to evaluate the percentage of @entity0 with primary @entity1 treated with antihypertensive drug(s), who achieved target arterial blood pressure (ABP), and to compare the characteristics of @entity0 with controlled and uncontrolled ABP, their current treatment, and treatment modifications. MATERIAL AND METHODS: A total of 429 18-80-year-old @entity0 with primary @entity1 treated for >=  1 year participated in this study. General practitioners collected data on @entity0 ' demographic and clinical characteristics, current treatment for primary @entity1 , and treatment modifications. RESULTS: According to physicians, 45.4% of @entity0 achieved target ABP levels. Adequately controlled ABP was documented more often in the group of low and moderate cardiovascular risk than in high- and very high-risk group (n=141, 62.9% versus n=54, 26.3%; P<0.0001). Based on ABP measurements, 160 (37.3%) @entity0 had ABP of <140/90 mm Hg. The majority of @entity0 were treated with a combination of two (n=153, 35.7%) to three (n=144, 33.6%) antihypertensive drugs. @entity0 with uncontrolled ABP more frequently than @entity0 with controlled ABP were given combination therapy. Treatment was not modified in 37.8% (n=162) of @entity0 , more commonly in those with controlled ABP. CONCLUSIONS: The level of @entity1 control in study population was far from optimal, especially in the group of @entity0 at high- and very high-risk where target ABP was lower. Almost 12% of @entity0 with uncontrolled ABP were still undergoing monotherapy, whereas 16% of @entity0 were not recommended any modifications of antihypertensive treatment despite their ABP was not controlled.

title: Evaluation of XXXX control and treatment in daily practice of family physicians.

answer: @entity1


abstract: OBJECTIVE: To compare detection rates of glaucomatous @entity1 ( @entity1 ) between the conventional 6 degrees x 6 degrees stimulus grid and locally condensed target arrangements in morphologically suspicious regions. METHODS: A total of 66 eyes of 66 @entity0 with @entity2 or @entity0 suspected of having @entity2 (34 females and 32 males; age range, 14-85 years) were enrolled in this study. Individual, local target condensation was realized by @entity3 ( @entity3 ) using a campimeter and compared with the results of @entity4 ( @entity4 ), obtained with the Humphrey Field Analyzer (30-2 grid). RESULTS: Twenty-three of the 66 @entity0 showed normal findings with both methods; 27 had concordantly pathological results. In 15 @entity0 we obtained normal findings with @entity4 , whereas @entity3 revealed @entity5 VFDs. Only one @entity0 showed @entity1 with @entity4 , whereas @entity3 results were normal. Scotoma detection rates significantly differed between the 2 methods (P<.001, sign test). Test duration with @entity3 was more than doubled compared with @entity4 . When considering only @entity3 points coinciding with the 6 degrees spacing of the 30-2 grid, there was no longer a significant difference between @entity3 and @entity4 (P>.25, sign test). This indicated that the target pattern, rather than the perimetric device, was most relevant for detecting @entity1 . Follow-up throughout a series of 3 subsequent sessions at 6-month intervals revealed repeatable results in more than two thirds of all eyes for both @entity3 and @entity4 . CONCLUSIONS: Fundus-oriented perimetry that uses individually condensed test grids significantly increases the detection rate of @entity1 in morphologically conspicuous areas compared with @entity4 using equidistant (6 degrees x 6 degrees) target arrangements. Repeatability is comparable between both methods.

title: Increased detection rate of glaucomatous @entity1 with locally condensed grids: a comparison between XXXX and conventional visual field examination.

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) is the most common subtype of @entity2 . Presently, one of the most important clinical predictors of survival in @entity3 @entity0 is the International Prognostic Index (IPI). Circadian rhythms are the approximate 24 hour biological rhythms with more than 10 genes making up the molecular @entity7 . OBJECTIVE: Determine if functional single nucleotide polymorphism in circadian genes may contribute to survival status in @entity0 diagnosed with diffuse large @entity3 . METHODS: Sixteen high-risk non-synonymous polymorphisms in circadian genes ( @entity7 , @entity8 , @entity12 , @entity6 , @entity11 , @entity1 , @entity4 , @entity5 , @entity10 , and @entity9 ) were genotyped by screening PCR. Results were visualized by agarose gel electrophoresis and confirmed by two-direction sequencing. Clinical variables were compared between mutated and non-mutated groups. LogRank survival analysis and Kaplan-Meier method were used to calculate the overall survival. RESULTS: @entity5 @entity13 variant showed significant difference in overall survival between @entity0 containing mutated genotypes and those with non-mutated genotypes (p = 0.047). LDH levels (p = 0.021) and IPI score (p < 0.001) also showed differences in overall survival. No clinical differences were observed in mutated vs. non-mutated @entity0 . CONCLUSIONS: This work suggests a role of @entity5 @entity13 in predicting a prognosis in @entity3 overall survival of @entity0 .

title: A XXXX polymorphism is associated with better overall survival in diffuse large @entity3 in Mexican population.

answer: @entity5


abstract: BACKGROUND: The troponin T ( @entity4 ) is frequently elevated in @entity1 ( @entity1 ) @entity0 . However, the relationship, if any, between the @entity4 level and @entity3 remains to be established. The aim was to investigate the possible correlation between the location and volume of @entity3 and the cardiac @entity4 serum level in @entity1 @entity0 . METHODS: The study consisted of consecutive @entity1 @entity0 admitted within 12h of @entity1 onset. The location and volume of the @entity2 was assessed with magnetic resonance imaging. Standard laboratory tests, including @entity4 and repeated electrocardiograms, were performed at admission and after 4h. Correlations between the @entity4 level and the location and volume of @entity3 and baseline parameters were tested with a Spearman correlation coefficient. Univariate and multiple logistic regression analysis (LRA) were used to determine the possible predictors of @entity4 elevation. RESULTS: Out of the 200 enrolled @entity0 , elevated @entity4 was present in 71 (36%). No correlation was found between the @entity4 serum levels and the location (P>0.05) nor volume of @entity3 (r=0.05, P=0.48). LRA identified creatinine (OR: 1.26 per 10 mol/L increase; 95% CI: 1.043-1.524), NT-proBNP (OR: 1.05 per 100 g/L increase; 95% CI: 1.018-1.093) and male gender (OR: 3.674; 95% CI: 1.025-13.164) as significant independent predictors of pathological elevation of @entity4 . CONCLUSIONS: Although elevated @entity4 serum level is relatively frequent in @entity1 @entity0 within the first 12h of @entity1 onset, it is not related to the location or volume of @entity3 . CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov (No. NCT01541163).

title: Troponin T: Correlation with location and volume of acute XXXX .

answer: @entity3


abstract: There is no effective therapy for @entity10 )-associated @entity7 /tropical @entity13 ( @entity11 / @entity12 ). Glucocorticoids are effective to reduce the motor disability in these @entity0 , but its role as anti- @entity6 drugs is unknown. Here it is reported the use of @entity3 in @entity11 / @entity12 . The goal was to find reliable molecular markers linked to treatment effectiveness. The clinical efficacy of @entity3 was studied in 22 @entity11 / @entity12 . The treatment was a single dose of 7.0   mg of systemic @entity15 . Pre-treatment samples were obtained immediately before @entity2 administration and post-treatment samples were collected after 5 days. @entity1 was evaluated by the Osame's Motor Disability Scales. Relative levels of @entity16 , @entity4 , @entity8 , @entity9 , @entity14 , and @entity17 mRNA were measured and the percentage of @entity5 (+) @entity4 (+) and @entity5 (+) @entity16 (+) populations was quantified in PBMCs by real-time PCR and flow cytometry, respectively. The same parameters were studied in eight untreated carriers. @entity15 treatment showed neurological improvement in 21 @entity11 / @entity12 @entity0 , with one @entity0 without response to treatment. This therapy was associated with a decrease in @entity16 mRNA load and @entity5 (+) @entity16 (+) T cells in @entity11 / @entity12 . Simultaneously, an increase in @entity4 mRNA and @entity5 (+) @entity4 (+) T cell was detected in these @entity0 . The other markers studied had no significant changes after treatment. Clinical improvement in @entity15 -treated @entity11 / @entity12 was associated with an inverse relationship between a decrease in @entity16 and an increase in @entity4 at the mRNA and protein levels. These results suggest that both @entity16 and @entity4 may represent potential biomarkers for drug treatment assessments in @entity11 / @entity12 .

title: Molecular and clinical effects of @entity15 in XXXX -associated @entity7 /tropical @entity13 @entity0 .

answer: @entity10


abstract: OBJECTIVE: To investigate prognostic significance of clinical and pathological stages in @entity0 with locally advanced @entity1 treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision. @entity0 AND METHODS: 210 @entity0 with locally advanced @entity1 ( @entity3 or cN+) treated with neo-CRT followed by total mesorectal excision. Treatment outcomes were compared according to clinical and pathological stage. Overall survival (OS), disease free survival (DFS) among @entity0 with different clinical stage and pathological stage after neo-CRT. RESULTS: The median follow-up time was 47  months (range, 14-98 months). Clinical T stage was associated with 5  year OS (p   =   0.042) and 5  year DFS (p   =   0.014) while clinical N stage was not associated with 5  year OS (p   =   0.440), 5  year DFS (p   =   0.711). @entity2 stage was associate with 5  year OS (p   =   0.001) and 5  year DFS (p   =   0.046); and N stage was associated with 5  year OS (p   =   0.001), 5  year DFS (p   =   0.002). The pathological stage was further classified into three groups: ypT0-2N0 in 91 @entity0 (43.3  %), ypT3-4N0 in 69 @entity0 (32.9  %) and ypT0-4N+ in 50 @entity0 (23.8  %). While pathological stage (ypT0-2 vs ypT3-4N0 vs ypT0-4N+) was associated with 5  year OS (87.9  %, 75.5  %, 56.7  %, p   =   0.000), 5  year DFS (74.5  %, 77.4  %, 50.5  %, p   =   0.003). Multivariate analysis showed that ypN stage was an independent prognostic factor for @entity0 5  year DFS. CONCLUSIONS: Pathological stage is strongly associated with treatment outcomes in @entity0 with locally advanced @entity1 treated with neo-CRT followed by total mesorectal excision, which may be used as guidance for further individualized treatment.

title: Prognostic significance of clinical and pathological stages on locally advanced XXXX after neoadjuvant chemoradiotherapy.

answer: @entity1


abstract: PURPOSE: Primary @entity3 of the colon and rectum are extremely rare, with an incidence of less than 1  % of @entity2 . Our aim in this study was to evaluate @entity0 characteristics, treatment strategy, and postoperative follow-up of @entity0 with @entity2 . METHODS: We reviewed our prospectively maintained @entity2 database for all @entity0 who were diagnosed with @entity2 between January 1990 and April 2009. RESULTS: Out of 5149 @entity0 with @entity2 , 11 @entity0 (0.2  %) met the study criteria. Median age at the time of diagnosis was 64. Median BMI was 28  kg/m(2). The @entity1 were localized in the rectum (n   =   8), right colon (n   =   2), and sigmoid colon (n   =   1). The pathologic stages of these @entity1 were I (n   =   1), II (n   =   4), III (n   =   3), and IV (n   =   3). Operations performed were abdominoperineal resection (n   =   4), right colectomy (n   =   2), total colectomy (n   =   1), low anterior resection (n   =   1), local excision (n   =   1), sigmoidectomy (n=1) and end colostomy creation (n   =   1). One @entity0 received intraoperative radiotherapy. Postoperative chemotherapy was given to eight @entity0 , and three @entity0 received postoperative radiation therapy. Median follow-up after diagnosis was 42  months (12-96). Three @entity0 developed recurrence after potentially curative surgery. Five @entity0 died from metastatic disease during follow-up. CONCLUSION: Squamous @entity2 can be detected in any part of the colon, generally presents at a later stage, and is associated with a poor prognosis. Surgery is the mainstay of treatment. Various adjuvant chemoradiation treatments appear not to influence the outcome. Further cases need to be analyzed in order to find more effective treatment regimens.

title: @entity2 : a rare XXXX with poor prognosis.

answer: @entity1


abstract: BACKGROUND: @entity4 ( @entity4 ) @entity1 in @entity0 with @entity5 ( @entity5 ) can lead to @entity2 and malfunction of the @entity4 . Intra-articular corticosteroid injections (IACI) have been suggested as a treatment modality against @entity4 @entity3 -related orofacial signs and symptoms. However, knowledge of the effect-durability of these injections remains unanswered. The aim of this pilot study was to evaluate the short and long-term effects of IACI on orofacial symptoms in a prospective observational study based on pre-specified clinical examination standards. METHODS: Thirteen @entity0 with @entity5 and @entity3 -related orofacial signs and symptoms were included in this prospective pilot study (median 17.2  years, IQR 15-18.4  years). All @entity0 received @entity4 IACI (11 bilateral and two unilateral) due to an insufficient response to previous @entity2 -management treatments. Three standardized clinical examinations were carried out: T1 prior to treatment, T2 short-term follow-up (mean 34  days post-treatment), T3 long-term follow-up (mean 333  days post-treatment). RESULTS: Significant @entity2 reduction was observed at the short-term follow-up (T2). Resolution of @entity2 after IACI was a rare finding at T2. Generally, the @entity2 significantly worsened between T2 and T3 examinations. The reported @entity2 levels rose between T2 and T3 indicating a loss of effect of the IACI at the long-term follow-up examination (T3). Non-significant improvements in @entity4 mobility were observed at T2 and T3. CONCLUSION: Our results suggest a palliative (not curative) effect of IACI for @entity4 @entity3 -related orofacial symptoms in @entity0 with long-term @entity2 complaints. The short-term improvements in signs and symptoms were partly resolved at the long-term follow-up.

title: @entity4 steroid injections in XXXX with @entity5 : an observational pilot study on the long-term effect on signs and symptoms.

answer: @entity0


abstract: PURPOSE: @entity1 is a burdensome, commonly comorbid condition. How @entity0 value various aspects of the safety and efficacy of available drugs has not been studied. The aim of the present study was to quantify @entity0 -rated utility by studying willingness to pay (WTP) for attributes of symptom relief via a discrete choice experiment (DCE). METHODOLOGY: Adult primary care @entity0 (West Virginia University Hospital) with comorbid @entity1 were enrolled. The attributes and levels examined were sleep onset latency (SOL; 10, 20,30 minutes), awakenings (1, 2, 3), @entity2 ( @entity2 ; 15,45, 60 minutes), @entity2 ( @entity2 ; 6, 7, 8 hours), hangover (none, mild, moderate), FDA-approved duration of use (short term, not restricted to short term, no restrictions), and out-of-pocket cost per month ( 20,  35,  50). Willingness to pay (WTP) data were analyzed using a random effects binary logistic regression model. RESULTS: A total of 82 @entity0 completed the DCE (74 analyzed). SOL, @entity2 , @entity2 , and cost were all found to predict treatment choice. Higher values of SOL, @entity2 , and cost resulted in decreased preference for a particular treatment, while higher @entity2 predicted increased preference. Modeling revealed an estimated marginal WTP of  66.69 for an example product that improved SOL by 10 minutes, reduced @entity2 by 15 minutes, and improved @entity2 by 1 hour. CONCLUSION: @entity0 WTP for symptomatic relief in @entity1 can help clinicians fine-tune interventions based on @entity0 preferences, provide evidence for drug formulary and reimbursement decisions, and potentially guide the development of novel drugs.

title: A Discrete Choice Experiment to Elicit XXXX Willingness to Pay for Attributes of Treatment-Induced Symptom Relief in Comorbid. @entity1 .

answer: @entity0


abstract: Therapeutic drug monitoring of @entity1 and @entity2 plays a significant role in the clinical follow-up of transplant @entity0 receiving IMS therapy. Success of transplant and favorable @entity0 outcome relies on maintaining adequate therapeutic drug levels. The purpose of this research is to assess the clinical utility of remote collection of DBS for immunosuppressant monitoring and compare the IMS level in paired collections of venous whole blood and DBS. @entity2 and @entity1 levels were clinically correlated in capillary blood collected from a finger poke with venous whole blood from pediatric, post-transplant @entity0 . The @entity0 took the dried blood spot card home with them with a pre-addressed, postage-paid envelope and mailed it back to the laboratory. Overall, a small but statistically significant negative bias was observed (-0.6  ng/mL, p  =  0.0011). A chart review was performed to assess whether clinical management would have changed, and none of the cases revealed a clinically significant change. @entity2 in DBS also correlated with venous levels. Overall, a small but statistically negative bias was observed (-0.8  ng/mL, p  =  0.029). In summary, analysis of IMS levels in DBS is possible, and the difference noted between capillary and venous blood is within the clinically acceptable limits.

title: XXXX and @entity2 in capillary dried blood spots allows for remote monitoring.

answer: @entity1


abstract: PURPOSE: @entity0 with @entity4 ( @entity4 ) have a cosmetic and functional problem due to limited shoulder abduction. Treatment options include excision of the prominent superior angle, scapular relocation procedures and subtotal scapulectomy. Excision of the superomedial angle results only in cosmetic improvement. Subtotal scapulectomy and relocation procedures are associated with ugly scars, extensive @entity2 and high incidence of @entity3 . @entity1 ( @entity1 ) is another surgical option that provides cosmetic and functional improvement. The aim of this study is to assess medium to long term results of @entity1 in treatment of @entity4 . METHODS: This is a prospective case series study. Seven @entity0 with @entity4 were treated at our unit. Age ranged from 5-13  years with an average of 8.4  years. All @entity0 were females with unilateral affection. All @entity0 underwent a @entity1 as described by Campbell. We used the Cavendish grading system together with combined shoulder abduction for assessment. Follow up averaged 4.6  years. RESULTS: All @entity0 and parents were extremely satisfied with the results of surgery. All @entity0 experienced an improvement in global shoulder abduction with an average gain in abduction of 52.9  . All @entity0 experienced an improvement in cosmetic appearance with better shoulder levelling. The Cavendish grade improved in all @entity0 . CONCLUSION: This study emphasizes the results of previous authors demonstrating that @entity4 can be treated successfully with a @entity1 . The procedure is simple and its results are reproducible.

title: XXXX in @entity4 .

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Maintenance of the vascular access is a crucial factor in hemodialysis, but large studies of factors that are predictive of @entity4 are lacking. DESIGN, SETTING, @entity0 , _ MEASUREMENTS: This prospective, multicenter study investigated a cohort to describe the management of vascular access and establish the influence of @entity2 as a risk factor. The cohort included 1710 @entity0 (aged 64.4 yr; 60% @entity0 ) who were followed every 3 mo at 119 centers during 12 mo. On inclusion, 9.6% had a catheter, 80.3% had a native @entity6 , and 10.1% had a @entity5 graft. RESULTS: Low baseline hemoglobin increased the risk for vascular access events. The risk was higher with a @entity5 graft and a catheter versus @entity6 . The multivariate model included @entity3 , previous @entity1 , and noncorrected @entity2 . The likelihood of remaining free of vascular access events 12 mo later was 0.727 (baseline hemoglobin <10.0 g/dl), 0.801 (10.01 to 11.0 g/dl), 0.814 (11.01 to 12.0 g/dl), and 0.833 (>12.0 g/dl), figures similar to those obtained with hemoglobin from the trimester before the event. The Cox model included @entity3 . CONCLUSIONS: Correcting @entity2 did not increase the risk for vascular access-related events, and @entity2 that was resistant to treatment identified a subgroup of @entity0 with higher comorbidity and higher likelihood of a vascular access event.

title: Course of vascular access and relationship with treatment of XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity1 plays a pivotal role in the pathogenesis of @entity4 ( @entity4 ) and @entity5 ( @entity5 ), the two most common types of @entity2 . A number of prior experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs), including @entity3 and @entity6 , may potentially protect against @entity2 . However, no observational study has examined the association between @entity3 duration and dose or other over-the-counter non- @entity3 NSAIDs, such as @entity6 , and @entity2 incidence. Furthermore, the association between NSAID use and risk of @entity5 is unclear. As part of the @entity2 Pooling Project, we harmonized data on 1,084,133 individuals ( @entity4 = 679, @entity5 = 225) from 10 U.S.-based prospective cohort studies. Cox proportional hazards regression models were used to evaluate multivariable-adjusted HRs and 95% confidence intervals (CI). Current @entity3 use, versus nonuse, was inversely associated with @entity4 (HR, 0.68; 95% CI, 0.57-0.81), which persisted when restricted to individuals not using non- @entity3 NSAIDs and in a 5- and 10-year lag analysis. The association between @entity3 use and @entity4 risk was stronger for users who reported daily use, longer duration use, and lower dosage. @entity6 use was not associated with @entity4 risk. @entity3 use was associated with a reduced @entity5 risk in @entity0 (HR, 0.64; 95% CI, 0.42-0.98) but not @entity0 (HR, 1.34; 95% CI, 0.89-2.01; P interaction = 0.01). The observed inverse association between @entity3 use and @entity2 in our study, together with previous data, suggests the merit of future intervention studies of @entity3 and other agents that affect chronic inflammatory pathways for @entity4 and possibly @entity5 . Cancer Prev Res; 8(12); 1-7.   2015 AACR.

title: NSAID Use and Risk of @entity4 and @entity5 : The XXXX Pooling Project.

answer: @entity2


abstract: PURPOSE: A randomized pilot trial evaluated the hypothesis that early intervention lessens @entity2 in the first year on aromatase inhibitors. A secondary aim was comparing the efficacy of two vaginal moisturizers. METHODS: Fifty-seven postmenopausal @entity1 with early stage @entity0 starting aromatase inhibitors were randomized to three treatment groups. All received a handout on managing sexual and other side effects. The Usual Care group received no additional therapy. The Active Treatment groups received a 6-month supply of a vaginal moisturizer (hyaluronic acid-based in Active Group-H and prebiotic in Active Group-P) and a vaginal lubricant and dilator, plus access to an educational website and phone @entity4 . Questionnaires completed at baseline, 6, and 12  months included the Female Sexual Function Index (FSFI), Menopausal Sexual Interest Questionnaire (MSIQ), Female Sexual Distress Scale-Revised (FSDS-R), and a menopausal symptom scale. RESULTS: Forty-nine @entity1 (86%) provided follow-up data. Mean age was 59 and 77% were non-Hispanic Caucasian. Sexual function was impaired at baseline, but remained stable over 12  months for all groups. The combined active treatment group had less @entity3 (P  =  0.07) and sexual distress (P  =  0.02) at 6  months than the Usual Care group. At 6  months, the Active-H group improved significantly more than the Active-P group on FSFI total score (P  =  0.04). CONCLUSIONS: Sexual counseling helped @entity1 maintain stable sexual function on aromatase inhibitors. Active intervention resulted in better outcomes at 6  months. IMPLICATIONS FOR CANCER SURVIVORS: This promising pilot trial suggests a need for more research on preventive counseling to maintain sexual function during aromatase inhibitor treatment.

title: A pilot randomized trial to prevent XXXX in postmenopausal @entity0 survivors starting adjuvant aromatase inhibitor therapy.

answer: @entity2


abstract: Assisted reproductive technologies (ART) used in fertility clinics include @entity1 ( @entity1 ) and @entity4 ( @entity4 ), followed by embryo transfer into the biological or a surrogate mother. Over 1,000,000 liveborn offspring--an estimated 1 in 150 United States newborns--have been produced worldwide by ART since 1978. @entity1 appears to produce healthy @entity0 in singleton pregnancies, though concerns remain regarding preterm deliveries, multiple pregnancies, as well as the longer-term consequences of all ART procedures. Clinical studies remain difficult to interpret and subject to confounding variables, as developmental problems may be due to a parent's reproductive conditions rather than, or in addition to, an ART procedure. Also, because of expense and time commitments, the United States ART clinical population is not fully representative of society diversities. This socio-economic skewing might compensate for negative effects, masking small, or modest @entity2 . Embryo splitting (ES), an ART procedure used only with animals, can produce genetically identical offspring. ES involves dividing four- to eight-cell embryos into separate blastomeres and implanting them into empty zona pellucida, followed by embryo transfer. Although these ART techniques have produced nonhuman primate offspring, there has been no research on behavioral safety. Here, we report the first study of behavioral development by @entity3 @entity0 produced through ES, @entity4 , and @entity1 . We assessed neonatal reflexes, self-feeding ability, recognition memory, object concept attainment, simple discrimination learning and reversal, and learning set (LS) acquisition. Although the sample sizes are small, we found no overall ART group delayed development. Surprisingly, the ES and @entity4 monkeys appeared to be accelerated in attaining age milestones involving sensory-motor behaviors and a difficult Well Hiding object concept task. We conclude that macaque monkeys may provide an excellent model for the study of early @entity0 development by offspring of parents with conditions requiring ART pregnancies, as well as a model for the behavioral study of genetic-environment interactions using identical twins produced by ES.

title: Neonatal behavior and @entity0 cognitive development in XXXX produced by assisted reproductive technologies.

answer: @entity3


abstract: OBJECTIVE: This study describes the relationship between @entity2 ( @entity2 ) and @entity3 in @entity0 following major surgery for @entity1 . DESIGN: Cross-sectional study using medical chart review, @entity0 interview, and test administration. METHOD: Fifty @entity0 were evaluated 6 months to 6 years following surgery using one global @entity2 measure (The Functional Assessment of Cancer Therapy-General [FACT-G]); three disease-specific measures of @entity2 (the HN module of the FACT [FACT-HNS], The University of Washington Quality of Life Scale [UWQOL], and The Performance Status Scale for @entity1 ); and one measure of @entity3 (The Beck Depression Inventory [BDI]). RESULTS: The study population showed a high occurrence of @entity3 (22%). A negative correlation existed between the BDI and @entity2 as measured by the FACT-G (r = -0.49, P < .001) and the UWQOL (r = -0.44, P = .003). When somatic symptoms of @entity3 were removed, the BDI remained correlated with @entity2 and was most highly correlated with the Emotional Well-Being (EWB) subscale of the FACT-G (r = -0.42, P = .003). There was no correlation between clinician judgments of EWB and any @entity0 -rated measures of @entity2 or @entity3 . CONCLUSIONS: Results demonstrate an inverse relationship between @entity0 -reported @entity2 and @entity3 . The lack of correlation between physician and @entity0 ratings of @entity2 and EWB stresses the importance of obtaining @entity0 ratings in addition to traditional clinician ratings when assessing outcomes. Finally, the multidimensional construction of the FACT with its specific subscales may make it a useful clinical tool for assessing @entity0 status and augmenting @entity0 interviews.

title: Relationship between quality of life and @entity3 in @entity0 with XXXX .

answer: @entity1


abstract: The production of @entity2 in the adult testis is mainly regulated by LH. @entity2 is essential for normal development of the male fetus. The regulation of @entity2 production in the fetal testis is less clear than in the adult testis, and there are indications that at least the onset of @entity3 production in the fetal testis takes place in an LH-independent way. The aim of the present study was to compare the onset of synthesis and pattern of expression of LH receptors and two important steroidogenic enzymes, @entity4 dehydrogenase (3beta-HSD) and 17alpha-hydroxylase/17,20-lyase ( @entity6 ), in fetal @entity0 gonads. Whole fetuses (13.5 and 14.0 postcoitum (p.c.), testes, and ovaries dissected from fetuses on Days 14.5 p.c. to 20.5 p.c. and testes obtained on Days 3, 5, and 7 postpartum were fixed in Bouin's solution and processed for immunocytochemistry. In all samples of fetal testis, 3beta-HSD was detected on Day 14.5 p.c., and immunoexpression of @entity6 appeared one day later on Day 15.5 p.c. Thereafter, immunoexpression of both enzymes remained intense throughout gestation and postnatally. In contrast, immunoexpression of LH receptors was detectable only from Day 16.5, when a few weakly positive cells were present, but it became more intense one and two days later. Similar to the immunostaining for 3beta-HSD and @entity6 , immunostaining for @entity5 remained strong throughout gestation and during the first 7 days of postnatal life. No immunoexpression of any of the three proteins studied was detected in the fetal ovary at any age. These data show very early immunoexpression of 3beta-HSD, which was detected one day before the reported start of @entity1 production by the fetal Leydig cells. In contrast, immunoexpression of LH receptors was evident only after immunoexpression of both the steroidogenic enzymes studied had became apparent and after the reported start of steroidogenesis, which is consistent with the theory that onset of steroidogenesis in the fetal @entity0 testis is an LH-independent process.

title: Immunoexpression of the steroidogenic enzymes 3-beta hydroxysteroid dehydrogenase and 17 alpha-hydroxylase, C17,20 lyase and the receptor for luteinizing hormone (LH) in the fetal XXXX testis suggests that the onset of Leydig cell steroid production is independent of LH action.

answer: @entity0


abstract: Study Design   Randomized controlled trial. Objective   The aim of this study was to assess the efficacy of the bone grafting substitute @entity6 -substituted @entity1 (SiCaP) compared with recombinant @entity0 @entity4 (rhBMP-2) and to evaluate the clinical outcomes over a period of 2 years. Methods   @entity0 undergoing PLF surgery for @entity5 at a single center were recruited and randomized to one of two groups: SiCaP (n   =   9) or rhBMP-2 (n   =   10). One @entity0 withdrew prior to randomization and another from the rhBMP-2 group after randomization. The radiologic and clinical outcomes were examined and compared. Fusion was assessed at 12 months with computed tomography and plain radiographs. Clinical outcomes were evaluated by recording measures of @entity2 , quality of life, disability, and neurologic status from 6 weeks to 2 years postoperatively. Results   In the SiCaP and rhBMP-2 groups, fusion was observed in 9/9 and 8/9 @entity0 , respectively. @entity2 and disability scores were reduced and quality of life increased in both groups. Leg @entity2 , disability, and satisfaction scores were similar between the groups at each postoperative point; however, @entity3 was less at 6 weeks and quality of life was higher at 6 months in the SiCaP group than the rhBMP-2 group. Conclusions   SiCaP and rhBMP-2 were comparable in terms of achieving successful bone growth and fusion. Both groups achieved similar alleviation of @entity2 and improved quality of life and neurologic, satisfaction, and return to work outcomes following PLF surgery.

title: Comparison of XXXX -Substituted @entity1 (Actifuse) with Recombinant @entity0 @entity4 (Infuse) in Posterolateral Instrumented Lumbar Fusion.

answer: @entity6


abstract: In a series of 704 @entity1 @entity0 who were admitted to the Research Institute for Brain and Blood Vessels-AKITA for the last 9.5 years (from October, 1974 to March, 1983), angiographic features of the anterior cerebral arteries and related @entity2 were analyzed with reference to the site of @entity1 . The age distribution was from 20 to 78 years (mean age 53 years), and the @entity0 to @entity0 ratio was 1:1.1. The total number of @entity1 was 866. The site distribution of @entity1 consisted of 230 (27%) anterior communicating, 269 (31%) middle cerebral, 282 (38%) internal carotid, 54 (6%) anterior cerebral, 45 (5%) vertebrobasilar and 6 other arteries. More than one @entity1 were found out in 137 cases. The total number of performed cerebral angiograms was 1840, in these right carotid arterial angiograms were 652, left carotid 644 and vertebral 544. Cases were divided into two groups, namely one who had the anterior communicating artery (Acom) @entity1 and the other who had not. Angiographic calibers of A1 portion (proximal portion of the anterior cerebral artery) were compared statistically between these two groups. As a result, three points as below were clarified in this series. 1) The Acom @entity1 group showed the significant asymmetry of A1 (p less than 0.005) compared to the other cases. 2) The left A1 portions were significantly dominant (p less than 0.05) to the right in the Acom @entity1 group. 3) @entity3 and aplasias of A1 were found in the Acom @entity1 group more frequently than in the other with statistical significance (p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Angiographic analysis of the anterior cerebral arteries with cerebral aneurysms--with special interest in the morphological aspect including so-called XXXX ].

answer: @entity2


abstract: BACKGROUND: Syndesmosis fixation of Lauge-Hansen SER IV, Weber B @entity5 is controversial. This study compared a matched pair of SER IV @entity0 with stress proven syndesmotic injuries with the same number without stress proven @entity7 in terms of functional, @entity2 , and radiologic result. METHODS: The study was based on a RCT-study comparing syndesmotic transfixation to no fixation in SER IV (Weber B)-type @entity5 . Twenty-four @entity0 with a @entity1 found on the intraoperative 7.5 Nm standardized external rotation test were compared to 24 @entity0 with a stable syndesmosis. The pairs were matched by @entity3 morphology, sex, and age. The primary outcome measure was ankle function as assessed by the Olerud-Molander score. Weight-bearing plain radiographs and 3T MRI of the injured ankle were used to assess ankle joint congruity and @entity4 , according to Kellgren-Lawrence classification and cartilage defects. RESULTS: The Olerud-Molander score was 86 in @entity1 @entity0 and 90 in @entity0 with normal syndesmosis (P = .28). The incidence of @entity7 on plain radiographs was not significantly different between the groups (Grade I 5% vs 21%; Grade II 86% vs 75%; Grade III 9% vs 4%; P = .34). MRI scans showed @entity6 in 54% of the @entity0 : 12 (56%) in the @entity1 group vs 13 (54%) in the group without @entity1 (P > .9). CONCLUSION: After 4 to 6 years of follow-up, clinical and radiologic outcome were not different in @entity0 with @entity1 compared to @entity0 with stable syndesmosis in SER IV (Weber B)-type @entity5 . LEVEL OF EVIDENCE: Prognostic Level II, comparative study.

title: Effect of Syndesmosis Injury in SER IV (Weber B)-Type Ankle Fractures on Function and Incidence of XXXX .

answer: @entity4


abstract: OBJECTIVE: To determine the impact of multispectral digital @entity1 analysis on German dermatologist biopsy decisions of atypical @entity1 . DESIGN: @entity0 were shown high-resolution clinical images of 12 atypical @entity1 previously analyzed by multispectral digital @entity1 analysis. @entity0 were asked if they would biopsy the lesion based on clinical images and high-resolution dermoscopy images and again when subsequently shown multispectral digital @entity1 analysis probability information. SETTING/ @entity0 : Forty-one dermatologists at a @entity3 conference in Germany in September 2014. MEASUREMENTS: Sensitivity, specificity, diagnostic accuracy, percent biopsying all @entity2 , and overall biopsy rates. RESULTS: Sensitivity for the detection of @entity2 following clinical evaluation was 64 percent. After receipt of multispectral digital @entity1 analysis probability information, sensitivity decreased nonsignificantly to 62 percent. Specificity with clinical evaluation was 57 percent and increased to 73 percent using multispectral digital @entity1 analysis. Overall biopsy accuracy increased from 60 percent with clinical evaluation to 68 percent with multispectral digital @entity1 analysis. The percentage of low-grade @entity4 chosen for biopsy decreased from 43 percent after clinical evaluation to 27 percent with multispectral digital @entity1 analysis. Finally, the overall percentage of lesions biopsied decreased from 52 percent with clinical evaluation to 42 percent after multispectral digital @entity1 analysis. CONCLUSION: Multispectral digital @entity1 analysis can be used reliably to detect @entity2 as well as clinical evaluation. Dermatologists can confidently use multispectral digital @entity1 analysis to significantly improve specificity and reduce their overall number of biopsies while increasing overall diagnostic accuracy.

title: The Impact of Multispectral Digital Skin Lesion Analysis on German Dermatologist Decisions to Biopsy Atypical Pigmented Lesions with Clinical Characteristics of XXXX .

answer: @entity2


abstract: OBJECTIVES: This study evaluates the clinical features of contact @entity1 and compares the results of voice therapy in operated versus unoperated cases. STUDY DESIGN: Retrospective review of 123 @entity0 with contact @entity1 . Thirty-six @entity0 had undergone one or more surgeries before phoniatric consultation. After their final operation, 33 @entity0 had recurrence. The three @entity0 who were cured by operation were not studied further. The course of disease in the 33 @entity0 with recurrence was compared with that of 87 @entity0 who did not have surgery. METHODS: The hospital records were reviewed concerning age, sex, symptoms, side of @entity1 , and outcome of treatment. RESULTS: The predominant symptoms were vocal fatigue, vocal discomfort, the need for excessive throat clearing, and hoarseness. The recurrence rate after operation was 92%. Twelve months after voice therapy, 35% of the operated group and 51% of the unoperated group were cured. The @entity0 who had surgery had almost twice as many sessions of voice therapy as the unoperated group, and their mean recovery time was 17 months, compared with 8 months for the unoperated group. CONCLUSIONS: The recurrence rate after surgery was high. Surgery may prolong the recovery time. Subjective symptoms diminished during voice therapy, but we cannot confirm that it was beneficial for the healing process.

title: A retrospective study of contact XXXX .

answer: @entity1


abstract: To assess the in vivo sensitivity of @entity2 to @entity3 and @entity1 in a hyperendemic area of southern Viet @entity5 , we studied 41 @entity0 and 21 adults from a remote commune who had uncomplicated @entity4 without previous treatment. @entity0 were randomly allocated to @entity1 (4 mg/kg on day 0 and 2 mg/kg on days 1-4) or @entity3 (10 mg/kg followed by 5 mg/kg at 6 h). Serial assessments were performed over 28 days. Of 31 @entity0 allocated @entity1 , nine (29%) redeveloped parasitaemia during follow-up compared with 23% (seven of 30) who received @entity3 . Of the 41 @entity0 , 15 (37%) had recrudescence/re-infection compared with only one of 20 adults (5%; p < 0.001). Significantly more @entity0 than adults failed on @entity3 treatment (37% vs 0%; p = 0.021) and one case showed RIII resistance. There was no significant difference in the case of @entity1 . In regression analysis, parasitaemia was an independent predictor of recrudescence/re-infection after @entity3 (p = 0.02). These data support the use of combination therapy such as @entity1 plus @entity3 for @entity4 in a hyperendemic area of Viet @entity5 . Primarily because of their greater parasite densities, @entity0 should be given higher doses of @entity3 (e.g. 25 mg/kg).

title: Treatment of XXXX in Vietnamese @entity0 : the need for combination therapy and optimized dosage regimens.

answer: @entity4


abstract: UNASSIGNED: e20521 Background: @entity6 , which targets KIT, @entity7 , @entity2 , has demonstrated efficacy in @entity0 with @entity4 after they experience @entity5 failure. A study from JCO reported @entity4 @entity0 with exon 9 gene mutation or wild type had more benefit receiving @entity6 treatment. We analysed the impact of primary and secondary gene mutation on @entity6 treatment in Chinese @entity4 @entity0 . METHODS: We assessed the @entity1 response according to RECIST criterion in 31 @entity0 with @entity5 -resistant/intolerant @entity4 , and examined the Kit/ @entity3 mutation status by using @entity1 specimens obtained before or after prior @entity5 therapy. Progression-free survival (PFS) was evaluated with Kaplan-Meier methods and log-rank tests. RESULTS: Primary gene mutations examination were performed in all the @entity0 and secondary gene mutations in nine @entity0 . Primary gene mutations were identified in 77.4% @entity4 . 61.3% had exon 11 mutation, 12.9% had exon 9 mutation, 3.2% obtained exon 17 mutation, no @entity7 gene mutation was found. 77.8% @entity0 had secondary gene mutation of the nine @entity0 and the more commonly secondary mutation were located in exon 13 and exon 17. Disease control rate with @entity6 were observed for primary genotype: KIT exon 9 (75%),wild-type Kit/ @entity3 (57%) and Kit exon11(53%). The @entity0 with exon 9 mutation had more longer PFS (60 weeks, vs. wild type 21 weeks, p=0.022; vs. exon 11 mutation 29 weeks, p=0.070). Two @entity0 with secondary Kit exon 13 mutation and one @entity0 without secondary mutation had PR or SD, but those @entity0 with primary or secondary Kit exon 17 muations showed no clinical benefit. CONCLUSIONS: @entity4 @entity0 with KIT exon 9 mutation response well to @entity6 treatment; @entity4 with KIT exon 17 mutation is @entity6 -resistant.

title: Correlation of kinase genotypes and activity of XXXX in @entity5 failure gastrointestinal stromal tumor.

answer: @entity6


abstract: Fetal and placental growth rate in @entity5 has been manipulated by removal of endometrial caruncles prior to conception. This produced two groups of fetuses, one in which prenatal growth rate was similar to normal and a second group in which the fetuses were about half of the normal size. The mortality in the latter group was high, particularly after catheterisation, and there was evidence of early @entity0 and fetal reabsorption. Prior to 125 days the relationship between fetal and placental size was poor, but after 126 days a close correlation between the two was apparent. The small fetuses had comparably small placentas and in all cases there was a close relationship between fetal and placental weight. The experimental @entity6 was associated with hypoglycaemia, @entity3 and hypoinsulinaemia. Plasma T3, T4 and particularly prolactin were very low in the small fetuses whilst levels of @entity4 and @entity2 were high. In contrast to the controls these fetuses showed little evidence of net @entity1 , @entity2 or @entity7 consumption. Infusion of 50% @entity1 into the pregnant ewe, sufficient to elevate maternal plasma @entity1 concentrations 2 to 3 fold, caused a comparable increase in the plasma concentrations of normal fetuses but only a 50% rise in the concentration in small fetuses. In contrast administration of 50% O2 to the ewes sufficient to cause a 2 to 3-fold increase in maternal @entity9 caused only a small increase of arterial @entity9 of normal fetuses but doubled that to normal levels in small fetuses. The results are discussed in relation to the effect of reduced placental size causing a fall in placental and transport and transport capacity and significance of this to the associated @entity8 .

title: Studies on experimental @entity6 in XXXX . The effects of a small placenta in restricting transport to and growth of the fetus.

answer: @entity5


abstract: Transvaginal ultrasound with SIS is a cost-minimizing screening tool for perimenopausal and postmenopausal @entity0 with @entity9 . Its use decreases the need for invasive diagnostic procedures for @entity0 without abnormalities, and ultrasound increases the sensitivity of detecting abnormalities in @entity0 with pathologic conditions. Vaginal sonography is preferred over uniform biopsy of postmenopausal @entity0 with @entity9 because it (1) is a less invasive procedure, (2) is generally painless, (3) has no complications, and (4) may be more sensitive for detecting @entity2 than blind biopsy. Transvaginal sonography is rarely nondiagnostic. Endometrial sampling is less successful in @entity0 with a thin endometrial stripe on ultrasound than in @entity0 with real endometrial pathologic condition. A limitation of ultrasound is that an abnormal finding is not specific: ultrasound cannot always reliably distinguish between benign proliferation, @entity7 , @entity6 , and @entity1 . Although ultrasound may not be able to distinguish between @entity7 and @entity1 , the next step in the clinical treatment requires tissue sampling. Because of the risk of progression of @entity2 , @entity0 with this finding may benefit from hormonal suppression, dilatation and curettage, endometrial ablation, or hysterectomy, depending on the clinical scenario. The inability to distinguish these two entities based on ultrasound alone should not be seen as a limitation because tissue sampling is required in either case. Occasionally (in 5% to 10% of cases), a @entity0 's endometrium cannot be identified on ultrasound, and these @entity0 also need further evaluation. Ultrasonography also may be used as a first-line investigation in other populations with abnormal uterine @entity4 . In a multicenter, randomized, controlled trial of 400 @entity0 with abnormal uterine @entity4 , the investigators found that transvaginal sonography combined with Pipelle endometrial biopsy and outpatient hysteroscopy was as effective as inpatient hysteroscopy and curettage. The subject, included @entity0 older than 35 years with PMB, @entity5 , @entity8 , @entity4 , or irregular menses. Transvaginal sonography may be a cost-effective. sensitive, and well-tolerated method to evaluate most @entity0 with @entity4 in combination with physical examination and endometrial biopsy and hysteroscopy us indicated. Hysteroscopy is likely to become the new gold standard in the future because of its ability to visualize directly the endometrium and perform directed biopsies as indicated. As office-based hysteroscopy becomes more practical and widespread, the technique may become more cost effective. An evaluation plan using transvaginal sonography as the initial screening evaluation followed by endometrial biopsy or, more likely, hysteroscopy is likely to become the standard of care (Fig. 12). It remains unproven whether certain @entity0 at higher risk for @entity2 should proceed directly to invasive evaluation. @entity0 on @entity3 with persistent recurrent @entity4 , @entity0 with significant risk factors for @entity2 , and @entity0 with life-threatening @entity4 comprise this group. Further studies are still necessary to evaluate high-risk @entity0 and determine whether ultrasound or biopsy is really the most cost-effective initial test.

title: Ultrasonographic evaluation of the endometrium in postmenopausal XXXX .

answer: @entity9


abstract: Granulomatous inflammatory lesions are a major histopathological feature of a wide spectrum of @entity0 infectious and @entity9 . Experimental @entity11 (EAT) with @entity8 histopathological features can be induced by @entity1 @entity15 (MTg)-sensitized spleen cells activated in vitro with MTg and anti-interleukin-2 receptor (anti- @entity13 ), anti- @entity12 , or anti- @entity4 (anti- @entity4 ) monoclonal antibody (MAb). These studies suggested that @entity4 -producing T cells requiring @entity12 for growth may negatively regulate activation of @entity8 EAT effector cells. As IL-12 promotes activation of @entity4 -producing @entity7 cells, the present study was undertaken to determine the role of IL-12 in activation of effector cells for @entity8 EAT. MTg-sensitized cells activated in vitro with MTg, anti- @entity13 MAb, and IL-12 induced severe, destructive @entity14 with @entity2 , fibrin deposition, and @entity3 . Many glands ultimately underwent @entity6 and became fibrotic; some also showed @entity3 and a mixed @entity2 of blood vessel walls indicative of a @entity10 . Induction of severe @entity8 EAT by IL-12 required MTg in vitro and was unrelated to the IL-12-induced increase in @entity4 production. IL-12 markedly increased @entity4 production but did not induce a shift to a @entity7 -dominant phenotype, as other @entity7 and @entity5 cytokines were generally unaffected and both @entity7 and @entity5 cytokines were expressed in recipient thyroids. Addition of IL-12 or neutralization by anti-IL-12 at various times indicated that IL-12 exerted its primary effects in the final 24 hours of the 72-hour culture and was not required in recipient @entity1 . Cells cultured with anti-IL-12, MTg, and anti- @entity13 MAb transferred mild lymphocytic EAT but little or no @entity8 EAT. Thus, IL-12 profoundly regulates the in vitro activation of effector cells that induce histologically distinct autoimmune inflammatory lesions in the thyroid.

title: Interleukin-12 promotes activation of effector cells that induce a severe destructive XXXX form of @entity1 experimental @entity11 .

answer: @entity8


abstract: @entity4 and venovenous bypass are frequently used surgical procedures when concomitant resection of the inferior vena cava is required during surgery of liver @entity1 involving the retrohepatic inferior vena cava close to the hepatic veins. However, the duration of @entity4 is limited due to the risk of @entity4 . Three @entity0 presented with severely compressed @entity3 . The surgical procedure involved initial taping of the inferior vena cava just below the hepatic veins by extrahepatic division and taping of the hepatic veins. After taping the inferior vena cava, hepatectomy with caval resection was performed by simply clamping the retrohepatic inferior vena cava, without the need for @entity4 or venovenous bypass. In all @entity0 the retrohepatic inferior vena cava were safely replaced with a prosthetic graft under stable hemodynamics. Duration of the inferior vena cava clamping was 31, 66, 75 minutes, respectively. No graft-related complications occurred, but 2 of the 3 @entity0 showed @entity2 associated with renal congestion postoperatively. The surgical procedure described herein is effective for the treatment of retrohepatic inferior vena cava in some @entity0 . However, when the case is complicated by chronic @entity2 or simultaneous nephrectomy is required, venovenous bypass should be performed.

title: Retrohepatic vena cava replacement of @entity4 without using XXXX or extracorporeal bypass.

answer: @entity4


abstract: BACKGROUND: A double stent system (covered stent in uncovered stent) was designed to provide long-term patency without @entity1 ingrowth or stent-related complications, such as stent migration, @entity6 , or @entity5 . PURPOSE: To investigate the safety and efficacy of double stents in @entity0 with @entity7 . MATERIAL AND METHODS: This prospective, nonrandomized, multicenter study enrolled 160 consecutive @entity0 (102 @entity0 ; mean age, 64 years; range, 33-91 years) with @entity7 treated with a double stent system from January 2010 to March 2012. RESULTS: The technical success rate of the double stent placement was 100%. No stent migration was observed. Procedure-related minor (self-limiting @entity8 [n   =   6] and @entity3 [n   =   2]) and major ( @entity5 [n   =   16], @entity6 [n   =   3], and @entity2 [n   =   2]) complications occurred in a total of 29 @entity0 . The mean serum @entity4 level, which was 8.9        5.6   mg/dL before drainage, decreased to 2.2        4.6   mg/ @entity9 month after stent placement (P   <   0.001). Successful internal drainage was achieved in 148 @entity0 (92.5%). During the mean follow-up period of 205 days, acute @entity6 (n   =   3) and @entity2 (n   =   2) occurred in five @entity0 . The median @entity0 survival and stent patency time were 135 days (95% confidence interval [CI], 96-160 days) and 114 days (95% CI, 83-131 days), respectively. Of 153 @entity0 , 22 (14.4%) presented with stent dysfunction due to sludge incrustation (n   =   17), @entity1 overgrowth (n   =   4), or blood clot (n   =   1), and required repeat intervention. @entity1 ingrowth was not observed in any of these @entity0 . CONCLUSION: Percutaneous treatment of malignant @entity7 using a double stent safely and effectively achieves internal biliary drainage.

title: A prospective, multicenter study of a double stent system for palliative treatment of XXXX .

answer: @entity7


abstract: BACKGROUND: The cognitive fusion questionnaire (CFQ) is a self-report questionnaire that assesses the extent to which individuals are psychologically entangled with, and dominated by the form-content of their thoughts. The aim of this study was to replicate the factor structure of CFQ in @entity3 , @entity1 , @entity2 , @entity4 , and normative population. It further examined the factorial invariance of the CFQ across these 5 groups. METHOD: Data from 299 @entity0 (N General Population   =  67, N @entity3   =  73, N @entity1   =  47, N @entity4   =  45, and N Obesity   =  60) were subjected to confirmatory factorial analysis ( @entity6 ) to replicate the structural model of CFQ dimensionality. RESULTS: @entity6 supported a 1-factor structure with good internal consistency and construct related validity. The 1-factor solution was also supported by a second independent data set, which showed a configural, strict measurement, and structural invariance of the 1-factor solution proposed. Multigroup @entity6 showed the configural invariance, strict measurement invariance, and structural invariance of CFQ across the 5 groups under study. CONCLUSIONS: The unidimensional model has both similar meanings and the same structure, but the measurement model across the groups was not the same. The study provides the first approach to CFQ to Portuguese population, as a reliable tool of general cognitive fusion. Furthermore, results indicated that CFQ has a coherent structure across multiple samples and clinical utility, as it discriminate individuals with @entity5 from those who do not.

title: Validation of the psychometric properties of cognitive fusion questionnaire. A study of the factorial validity and factorial invariance of the measure among XXXX , @entity1 , @entity2 , @entity4 , and general populations.

answer: @entity3


abstract: BACKGROUND: The combined effects of balanced transfusion ratios and use of procoagulant and antifibrinolytic therapies on @entity1 -induced exsanguination are not known. The aim of this study was to investigate the combined effect of transfusion ratios, @entity3 and products containing @entity5 on the outcome of injured @entity0 with @entity2 . METHODS: A prospective multicentre observational study was performed in six level 1 @entity1 centres. Injured @entity0 who received at least 4   units of red blood cells (RBCs) were analysed and divided into groups receiving a low (less than 1   :   1) or high (1 or more   :   1) ratio of plasma or platelets to RBCs, and in receipt or not of @entity3 or @entity5 products ( @entity5 concentrates or cryoprecipitate). @entity6 models were used to assess the effect of transfusion strategies on the outcomes 'alive and free from massive transfusion' (at least 10   units of RBCs in 24   h) and early 'normalization of @entity4 ' (defined as an international normalized ratio of 1  2 or less). RESULTS: A total of 385 injured @entity0 with ongoing @entity2 were included in the study. Strategies that were independently associated with an increased number of @entity0 alive and without massive transfusion were a high platelet to RBC ratio (odds ratio (OR) 2  67, 95 per cent c.i. 1  24 to 5  77; P   =   0  012), a high plasma to RBC ratio (OR 2  07, 1  03 to 4  13; P   =   0  040) and treatment with @entity3 (OR 2  71, 1  29 to 5  71; P   =   0  009). No strategies were associated with correction of @entity4 . CONCLUSION: A high platelet or plasma to RBC ratio, and use of @entity3 were associated with a decreased need for massive transfusion and increased survival in injured @entity0 with @entity2 . Early normalization of @entity4 was not seen for any transfusion ratio, or for use of @entity3 or @entity5 products.

title: Combined effect of therapeutic strategies for @entity2 on early survival, transfusion needs and correction of XXXX .

answer: @entity4


abstract: Several animal species have shown a teratogenic response to inhaled or ingested @entity6 (EGME). The present study examined the developmental phase specificity and dose-response characteristics of EGME-induced embryotoxicity. Pregnant @entity5 @entity0 (vaginal plug positive day = gestation Day [gd]0) received multiple or single doses of EGME by gavage between @entity7 and 14. Fetuses were examined on gd 18 for @entity4 . EGME was not maternally toxic after multiple doses of 250 mg/kg or a single administration of up to 500 mg/kg. EGME induced embryotoxicity as manifested by reduced gd 18 fetal weights and increased resorptions. The observed @entity2 were specifically related to the developmental stage at the time of exposure. @entity3 resulted after EGME exposure between @entity7 to 10 whereas @entity1 (syndactyly, @entity9 , and stunted digit No. 1) predominated during later stages of development. @entity1 were maximal after administration on gd 11, and forepaws exhibited greater susceptibility than hindpaws. The no observed effect dose for the induction of digit @entity2 after a single administration of EGME on gd 11 was 100 mg/kg. At 175 mg EGME/kg @entity1 were induced without any concurrent @entity8 while at 250 mg/kg and above, @entity1 occurred concurrently with reduced fetal body weight.

title: Developmental phase-specific and dose-related teratogenic effects of @entity6 in XXXX @entity0 .

answer: @entity5


abstract: 1. Substrate-saturation curves of brain hexokinase for MgATP(2-) were sigmoidal at sub-saturating concentrations of @entity0 when the @entity2 / @entity1 ratio was maintained at 1:1. Under identical conditions, except that @entity2 was present in excess, hyperbolic curves were observed. 2. The number of binding sites (calculated from Hill plots) is 1.8 at a @entity2 / @entity1 ratio 1:1, and 1.0 with excess of @entity2 . The apparent K(m) for @entity3 is 6.5x10(-4)m at a @entity2 / @entity1 ratio 1:1, and 3.5x10(-4)m with excess of @entity2 . 3. Interdependence between substrate-binding sites was indicated by the effects of varying the concentration of @entity0 . The sigmoidality and deviation from Michaelis-Menten kinetics at a @entity2 / @entity1 ratio 1:1 became less pronounced with increasing @entity0 concentration. Also, although substrate-saturation curves for @entity0 were hyperbolic when the @entity2 / @entity1 ratio was 1:1, reciprocal plots were non-linear. These were linear with excess of @entity2 . 4. High concentrations of @entity2 ( @entity2 / @entity1 ratios above 5:1) were inhibitory. 5. The results are taken to indicate homotropic co-operative binding of @entity3 and that @entity2 is an allosteric activator. Possible implications in regulation are discussed.

title: Allosteric activation of brain hexokinase by magnesium ions and by magnesium ion-- XXXX complex.

answer: @entity1


abstract: OBJECTIVES: We evaluated the functional and radiologic results of surgical treatment in @entity0 with displaced @entity1 . METHODS: The study included 21 @entity0 (13 males, 8 females; mean age 35 years; range 21 to 63 years). Before surgery, all the @entity0 were evaluated with anteroposterior, iliac, and obturator oblique views and computed tomography scans. According to the Letournel-Judet classification, the @entity1 were simple in 10 @entity0 and complex in 11 @entity0 . Twelve @entity0 had posterior wall and/or the posterior column @entity1 . Four @entity0 underwent closed reduction under emergency settings for accompanying @entity4 . The mean time to surgery was 4.8 days (range 1 to 13 days). Surgery was performed by the Kocher-Langenbeck approach (n=12), a triradiate approach (n=5), and a modified extended iliofemoral approach (n=4). Functional results were assessed by the D'Aubigne-Postel's knee scoring system and radiologic results using anteroposterior, iliac, and obturator oblique views. The mean follow-up was 31 months (range 19 to 64 months). RESULTS: Functional results were excellent in eight @entity0 (38.1%), good in seven (33.3%), satisfactory in four (19.1%), and poor in two @entity0 (9.5%). Radiologic examination showed posttraumatic @entity5 in four @entity0 (19.1%), @entity3 in three @entity0 (14.3%), and @entity2 in two @entity0 (9.5%). Radiologic results were excellent and good in 16 @entity0 (76.2%), satisfactory in three @entity0 (14.3%), and poor in two @entity0 (9.5%). CONCLUSION: Clinical and radiologic results showed concordance. The presence of dislocations and inadequate reduction were associated with poor functional results.

title: [Clinical and radiologic results of surgically-treated XXXX ].

answer: @entity1