abstract: BACKGROUND: It is important to assess physical activity objectively during daily life circumstances, to understand the association between physical activity and diseases and to determine the effectiveness of interventions. Accelerometer-based physical activity monitoring seems a promising method and could potentially capture all four FITT (i.e. Frequency, Intensity, Time, Type) components of physical activity considered by the World Health Organization (WHO). AIM: To assess the four FITT components of physical activity with an accelerometer during daily life circumstances and compare with self-reported levels of physical activity in @entity0 with @entity2 ( @entity1 ) and a healthy control group. METHODS: @entity0 (n=30) with end-stage knee @entity1 and age-matched healthy subjects (n=30) were measured. An ambulant tri-axial accelerometer was placed onto the lateral side of the upper leg. Physical activity was measured during four consecutive days. Using algorithm-based peak detection methods in Matlab, parameters covering the four FITT components were assessed. Self-reported physical activity was assessed using the Short questionnaire to assess health enhancing physical activity (SQUASH). RESULTS: Knee @entity1 @entity0 demonstrated fewer walking bouts (154   79 versus 215   65 resp.; p=0.002), step counts (4402   2960 steps/day versus 6943   2581 steps/day; p=0.001) and sit-to-stand (STS) transfers (37   14 versus 44   12; p=0.031) compared to controls. Knee @entity1 @entity0 demonstrated more time sitting (65   15% versus 57   10% resp.; p=0.029), less time walking (8   4% versus 11   4% resp.; p=0.014) and lower walking cadence (87   11steps/min versus 99    8steps/min resp.; p<0.001). Accelerometer-based parameters of physical activity were moderately-strong (Pearsons's r= 0.28-0.49) correlated to self-reported SQUASH scores. CONCLUSION: A single ambulant accelerometer-based physical activity monitor feasibly captures the four FITT components of physical activity and provides more insight into the actual physical activity behavior and limitations of knee @entity1 @entity0 in their daily life.

title: Accelerometer-based Physical Activity Monitoring in XXXX with @entity2 : Objective and Ambulatory Assessment of Actual Physical Activity During Daily Life Circumstances.

answer: @entity0


abstract: The first published @entity4 @entity1 in @entity0 had been reported in 1936 from Luleburgaz (located in European part-Thrace region-of @entity0 ), and the second was in 1945 again in the same province. Following a long period of time without any @entity4 report from Thrace region, in 2005 another @entity1 occurred in a village of Edirne, another province located in the same region. Since there is presumptive evidence of circulation of the infectious agent, @entity3 in Thrace region of @entity0 , a large scale seroepidemiological study is needed. In this study, the presence of antibodies against @entity3 in 1782 subjects, choosen by "thirty cluster" method, inhabiting in 90 different villages of Edirne, Kirklareli, and Tekirdag provinces in Thrace Region, were investigated. The subjects were included to the study on the basis of volunteering (74.3% were male; mean age: 46 years; age range: 6-92 years) and demographical characteristics and their possible risky behaviours were recorded in a questionnaire form. Antibodies specific for @entity3 were screened by microagglutination test, and were found positive in five (0.3%) of the subjects between the titers of 1/20- 1/160. All of the seropositive subjects were adult males (ages between 22-74 years); three were living in the two villages of Kirklareli, while the others were from the villages of Tekirdag and Edirne. Rose Bengal test was also found positive in three of the seropositive subjects, and with the thought of a probable cross reaction they were taken into an advanced investigation for @entity2 . The risk evaluation revealed that male gender, being together with livestock and exposure to ticks were the major risk factors. Since the data of this study indicated that @entity3 is in circulation in Thrace Region, the educational programmes for both the healthcare workers and inhabitants of this region should be attempted for the prevention of a possible @entity1 .

title: [Investigation of XXXX seroprevalence in the rural area of Thrace region in @entity0 ].

answer: @entity4


abstract: The assay of intraperitoneal (ip) injection to @entity1 was used as experimental system to study the mechanisms of carcinogenic effects of fibrous dusts. With this test system, fibers were shown to induce @entity3 in the peritoneal cavity. Although the data of the ip assay are discussed controversially in terms of risk assessment, it is a valuable tool to investigate the molecular mechanisms of @entity2 in vivo. This test system allows one to investigate both the effects of fibers on signal transduction and the genotoxic potential of fibers. On the level of mRNA expression, different stages of fiber-induced @entity0 development in the peritoneal space were examined using differential display techniques. Genes of signal transduction pathways are mainly affected by the fiber treatment; for example, the activation of genes for the AP-1 transcription factor could be observed in the tissues of the peritoneal cavity. Thus, our in vivo data confirm the findings reported from cell culture systems. Moreover, our results from the differential display assays reveal that genes involved in the integrin-linked signal transduction are upregulated. In addition, the ip assay can be applied to transgenic animals to perform mutagenicity testing. Using the Big Blue transgenic animal system, we provide data of a significant increase in mutation frequency after treatment with @entity4 asbestos.

title: Effects of @entity4 Fibers on the Peritoneal Mesothelium of XXXX .

answer: @entity1


abstract: BACKGROUND/AIMS: Surgical resection is not generally indicated for para-aortic lymph node (PALN) @entity1 from @entity2 . However, the clinical significance of PALN dissection (PALND) in the current @entity3 of modern chemotherapy has not been fully discussed. METHODS: Between November 2006 and February 2013, 14 @entity0 underwent PALND for @entity2 and were proven as having pathological PALN @entity1 . The median follow-up was 33.2 months. RESULTS: Primary location was the right-colon in 2 @entity0 , and the left-colon or rectum in 12 @entity0 . The timing of @entity1 was metachronous in 5 @entity0 and synchronous in 9 @entity0 . Eleven @entity0 (79%) received perioperative aggressive modern chemotherapy. Neoadjuvant chemotherapy with targeted drugs was introduced in 9 @entity0 (64%) and 6 @entity0 received adjuvant chemotherapy. Recurrence after PALND occurred in 12 @entity0 (86%). The most common site was the lung in 6 @entity0 (43%). The 1- and 3-year disease-free survivals were 39.3 and 7.9%, respectively. The 3-year overall survival were 41.2%. CONCLUSION: The recurrence rate after PALND for strictly selected @entity0 was quite high even in the current @entity3 of modern chemotherapy. However, some @entity0 achieved long-term survival or could be cured. Therefore, we should re-evaluate the efficacy of PALND in a larger prospective study.

title: Clinical Significance of Para-Aortic Lymph Node Dissection for Advanced or Metastatic @entity2 in the Current XXXX of Modern Chemotherapy.

answer: @entity3


abstract: The natural history of @entity4 is characterized, in particular, in younger @entity0 by @entity5 , in the majority of @entity0 by progressive @entity3 [14, 26, 27, 33-36]. With the aid of beta-adrenergic receptor blockers, @entity2 channel blockers and antiarrhythmic agents the clinical outlook for most of the @entity0 can be improved [17, 19, 23, 28]. @entity0 who do not respond to medical treatment can be regarded as possible candidates for surgical revision of the left ventricular outflow tract. In consideration of surgical treatment, two morphologic and hemodynamic forms of the disease must be differentiated: the typical subaortic muscular @entity6 in the region of the outflow tract and the atypical, more mid-ventricular muscular @entity6 with systolic entrapment of a distal portion of the ventricle in which frequently a typical subaortic @entity6 also may be present [15, 43]. As a result of @entity6 which may substantially compromise left ventricular ejection during systolic contraction, in @entity4 there is a deviation of the left ventricular major @entity8 , @entity7 in the sequence of contraction, @entity6 of the left ventricular walls, diminished diastolic compliance and, to a varying extent, @entity1 . Diagnostically useful findings are a mid-systolic murmur at the aortic valve, bisferiens carotis pulse, systolic pressure gradient between the left ventricle and the aorta and a postextrasystolic paradoxical pressure response. Echocardiographically, @entity10 , systolic anterior motion of the anterior mitral valve leaflet, premature mid-systolic closure of the aortic valve and an enlarged left atrium will be detected. Surgical intervention is indicated for @entity0 with class III clinical symptoms (NYHA) not amenable to medical treatment and pressure gradients between left ventricle and aorta, at rest or postextrasystolically, in excess of 50 mm Hg. An overview of the variety of surgical approaches and procedures employed for @entity4 is provided by Table 1. From initial attempts to eliminate the outflow tract obstruction by myotomy, the @entity9 was developed in which an about 1 cm wide section of muscle is resected; this procedure can be carried out from a transaortic, transatrial or transventricular approach [4, 9, 21, 22, 24, 38, 39, 47]. Under the assumption that the anterior motion of the anterior mitral valve leaflet contributes to systolic obstruction, some authors recommended reconstructive procedures or replacement of the mitral valve.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [ XXXX : surgical treatment and results].

answer: @entity4


abstract: BACKGROUND: The relationship between @entity4 and @entity7 is mainly sustained by data retrieved from cross-sectional studies focused on cardiovascular risk factors. We aimed to assess the presence of @entity4 as a risk factor for developing @entity7 in a @entity1 population. METHOD: A 10-year prospective, primary care, multicentre study in a randomly selected cohort. @entity4 presence @entity3 , @entity6 and/or peripheral ischaemia. @entity7 diagnosis was based on clinical neurological examination as well as the @entity2 score and nerve conduction studies. RESULTS: Three hundred and ten (N=310) @entity0 were initially recruited. Two-hundred and sixty seven (N=267) @entity0 were included in the study. @entity7 cumulative incidence was 18.3% (95% confidence intervals 14.1-23.4; N=49). @entity7 development was significantly more frequent in @entity0 presenting with @entity4 at baseline (P=0.01). In the final logistic regression analysis, the presence of @entity4 remained associated with an increased risk for @entity7 (odds ratio 2.32, 95% confidence intervals 1.03-5.22) in addition to @entity1 duration and low density lipoprotein- @entity5 levels. CONCLUSIONS: In our series, @entity1 @entity0 with @entity4 at baseline present with an increased risk of developing @entity7 at 10 years of follow-up. Our results suggest that measures aimed at the prevention, control and treatment of @entity4 can also help prevent @entity7 development.

title: @entity4 predicts diabetic peripheral polyneuropathy in subjects with type 2 XXXX : A 10-year prospective study.

answer: @entity1


abstract: The purpose of this paper is to describe seasonal fluctuations in hospitalisation for @entity1 in Finland over the period 1972-1993. Treatment periods with @entity1 as the main or secondary diagnosis were collected from the national hospital discharge register. The seasonality of monthly hospital admissions was analysed using the X11 ARIMA procedure. The population of Finland numbered 5 million during the period concerned, and there were a total of 453,393 @entity1 treatment periods, 17.9% in the age-group under 16 years, 29.6% among working-age @entity0 and 52.5% among @entity0 aged over 64 years. The number was greatest in the total population in December (20.5%) and January (25.1%) and lowest in July (-19.7%) and August (-24.3%). Seasonal fluctuations in @entity1 hospitalisations pointed to the same trend in both the sexes, in that the number increased in winter and decreased in summer. @entity0 's admissions began to increase a month earlier than those of the other age groups, however, in November, while a transient increase in admissions of working age @entity0 in March is attributable to the more extensive use of hospital services by army conscripts. Admissions of @entity0 aged over 64 years fell more slowly from the winter peak than did those of the other segments of the population. The winter peak in hospital admissions for @entity1 can be anticipated administratively by increasing the number of hospital beds and intensifying outpatient care. It may not be necessary to increase health care resources to achieve this, however, as the necessary resources can be obtained through reductions in the summer months. Proper recognition of admission peaks, the points in time at which these regularly occur and the target groups within the population can contribute greatly to health care planning and its economy.

title: Seasonal fluctuations in hospitalisation for XXXX in Finland.

answer: @entity1


abstract: BACKGROUND: Atherosclerotic plaques indicate the occurrence of @entity1 events and it is a difficult task for clinical physicians. Grape seed @entity5 extract (GSPE) has been reported to exert an antiatherogenic effect by inducing regression of @entity2 in animal experimental studies. In this study, the antiatherogenic effect of GSPE has been investigated in clinical use. METHODS: Consecutive 287 @entity0 diagnosed with asymptomatic carotid plaques or abnormal plaque free @entity3 ( @entity3 ) were randomly assigned to the GSPE group (n = 146) or control group (n = 141). The @entity0 in the GSPE group received GSPE 200 mg per day orally, while @entity0 in the control group were only enrolled in a lifestyle intervention program. Carotid ultrasound examination was performed at baseline and 6, 12, 24 months during follow-up. Mean maximum @entity3 (MMCIMT), plaque score, echogenicity of plaques and @entity1 vascular events were recorded. RESULTS: As anticipated, after treatment, GSPE resulted in significant reduction in MMCIMT progression (4.2% decrease after six months, 4.9% decrease after 12 months and 5.8% decrease after 24 months) and plaque score (10.9% decrease after six months, 24.1% decrease after 12 months and 33.1% decrease after 24 months) for the primary outcome, while MMCIMT and plaque score were stable and even increased with the time going on in control group. The number of plaques and unstable plaques also decreased after treatment of GSPE. Furthermore, the carotid plaque can disappear after treatment with GSPE. The incidence rate for @entity1 ( @entity1 ), arterial revascularization procedure, and hospital readmission for @entity4 in GSPE group were statistically significant lower (P = 0.02, 0.08, 0.002, respectively) compared with the control group. CONCLUSIONS: GSPE inhibited the progression of MMCIMT and reduced carotid plaque size in GSPE treated @entity0 , and with extended treatment, the superior efficacy on MMCIMT and carotid plaque occurred. Furthermore, the GSPE group showed lower rates of clinical vascular events.

title: Beneficial clinical effects of grape seed XXXX extract on the progression of carotid @entity2 .

answer: @entity5


abstract: Microneurographically recorded sympathetic outflow to the @entity0 muscle vascular bed is traditionally quantified by identifying pulse-synchronous bursts of impulses in a mean voltage neurogram and expressing them in terms of bursts per minute (burst frequency) or bursts per 100 heart beats (burst incidence). As both these measures show large inter-individual differences in resting healthy subjects, a problem arises when comparing sympathetic traffic in cross-sectional studies, making moderate differences in muscle sympathetic nerve activity (MSA) between groups difficult to identify. Absolute measures of the strength of the sympathetic discharges (burst amplitude or area) can also be evaluated. However, as they critically depend on the proximity of the microelectrode to the recorded fibres, such measures cannot be used for interindividual comparisons. The aim of the present study was to evaluate the use of relative burst amplitude spectra for quantification of MSA, describing the proportion of small vs large bursts in a neurogram. We recorded MSA in 18 @entity0 with mild to moderate @entity1 ( @entity1 ) (New York Heart Association functional classes I-IIIA) and 18 matched healthy controls. Sympathetic activity was expressed as burst frequency, burst incidence and burst amplitude spectra. When comparing the traditional burst counts between the groups (presented as the median and 25th-75th percentiles) there was a tendency towards higher MSA in @entity1 @entity0 , but the difference was not significant (42 (34-52) vs 53 (41-63) bursts/min, 62 (51-78) vs 69 (52-84) bursts/100 heart beats, both ns). Relative burst amplitude spectra, on the other hand, were clearly shifted to the right in the @entity1 group compared to the control group (median burst amplitudes 42 (34-45) vs 30 (28-35), P = 0.0002). Relative burst amplitude spectra thus appear to provide a more sensitive indicator of altered MSA than traditional burst counts. The right-ward shift of these spectra may suggest that sympatho-excitation occurs early in the development of @entity1 .

title: Relative burst amplitude in XXXX muscle sympathetic nerve activity: a sensitive indicator of altered sympathetic traffic.

answer: @entity0


abstract: PURPOSE: Blood-brain barrier and blood- @entity0 barrier (BBB/BTB) are the main limitations for chemotherapeutics in @entity1 therapy. Focused ultrasound (FUS) combined novel @entity4 -loaded liposomes (LIP- @entity5 ) was applied to open the BBB/BTB and improve the efficiency of @entity1 -targeted chemotherapy. EXPERIMENTAL DESIGNS: Particle size, Zeta potential and drug encapsulation efficiency were evaluated. @entity3 model @entity2 were established to evaluate the BBB/BTB disruption and the @entity1 inhibition in vivo. With Evans Blue (EB) as the model, the permeability of BBB/BTB was evaluated. The @entity1 inhibition of FUS+LIP- @entity5 was investigated by magnetic resonance images (MRI) and confocal laser microscope. The activities of b1-intergrin and @entity6 proteins in response to FUS-mediated BBB/BTB opening were explored. RESULTS: LIP- @entity5 has suitable nanoscale size and good polydispersity index. From EB extravasation experiment, FUS increased the BBB/BTB penetration and accumulation of EB in the @entity1 . LIP- @entity5 combined with FUS could efficiently enhance @entity5 penetrate into the model @entity2 brains, realizing strong @entity1 inhibition in vivo. Among @entity5 -administrated groups, FUS+LIP- @entity5 group showed the beat inhibition on @entity1 . FUS+LIP- @entity5 group reduced the @entity0 progression ratio from 1.18 to -0.20, extending the median survival from 23d to 57.5d. b1-intergrin and @entity6 were significantly decreased after FUS treatment, which explained the molecular mechanisms of BBB-opening by FUS. CONCLUSIONS: Glioma-targeted inhibition can be realized by using FUS induced BBB/BTB-opening technique combined with LIP- @entity5 . This combined technology will be developed as a potential strategy for @entity1 -targeted therapy.

title: Using FUS induced BBB/BTB-opening technique combined with @entity4 liposomes to improve XXXX -targeted inhibition.

answer: @entity1


abstract: It is suggested that growth factors support the process of maturation and differentiation in the @entity0 oviduct. Fibroblast growth factors (FGF) and insulin-like growth factors (IGF) are possible influences on these processes. The present study describes for the first time the expression of @entity4 and their receptors as well as @entity5 and the corresponding IGF receptor type 1 in the oviduct of the New World monkey @entity3 . Because of the limited RNA yields from oviducts, reverse transcription-polymerase chain reaction (RT-PCR) was performed to estimate expression levels. Expression patterns were found to be similar for all examined growth factors and receptors: the highest mRNA contents were obtained at the late proliferative and early to midsecretory phases, compared with lower levels during the early proliferative phase. Elevated amounts of these RNAs were correlated with high serum @entity1 but not with @entity2 concentrations. Each PCR product showed a high degree of homology (> 92%) to the known @entity0 sequences. Immunohistochemical analysis indicated greater specific staining for @entity4 and @entity6 before ovulation on the luminal epithelial surface of marmoset oviducts in comparison to the other cycle phases. Differences in staining intensity were not observed between the ampulla and isthmus. In summary, the marmoset oviduct expresses all components of functional FGF and IGF systems, thus suggesting auto-/paracrine effects of these growth factors within the primate oviduct, possibly under the control of estrogenic hormones.

title: Insulin-like and fibroblast growth factors and their receptors are differentially expressed in the oviducts of the XXXX monkey ( @entity3 ) during the ovulatory cycle.

answer: @entity3


abstract: OBJECTIVE: To investigate the clinical predictors of @entity3 ( @entity3 ) in @entity0 with @entity1 ( @entity1 ) and other connective tissue diseases. METHODS: Four hundred and one consecutive @entity0 with newly diagnosed @entity1 between January 2010 and January 2013 were enrolled in the study. During the study period, 729 consecutive @entity0 with non- @entity1 connective tissue diseases were also included, and a cross-sectional study was performed. Medical records were reviewed. Only those @entity0 with data for 2 years were considered in the analysis (338). RESULTS: Erosive @entity3 was noted in 60.4% (204 /338) of @entity0 with @entity1 and occurred early in @entity1 . The multivariate logistic regression analysis indicated that @entity7 , @entity2 , and positive anticyclic citrullinated peptide antibody (ACPA) were strongly associated factors for the occurrence of @entity3 in @entity1 @entity0 . Erosive @entity3 was also noted in 1.5% of @entity0 with @entity6 , 5.8% of @entity0 with primary @entity4 , and 9.1% (3/33) of @entity0 with @entity5 . When compared with @entity0 without @entity3 , high level and prominently higher positive rate of ACPA was found in these @entity0 with @entity3 . On receiver operating characteristic curve analysis, ACPA exhibited a maximum sensitivity with a cutoff value of 1.6 U/mL and 0.6 U/mL for @entity1 and @entity6 @entity0 , respectively. CONCLUSION: Erosive @entity3 had a high prevalence in Chinese @entity1 @entity0 and occurred early. @entity2 , @entity7 , and ACPA were associated with @entity3 in @entity1 . Erosive @entity3 also could be detected in @entity6 , primary @entity4 , and @entity5 . Anticyclic citrullinated peptide antibodies were also associated with @entity3 in these diseases. Intensive monitoring for erosions was recommended for @entity1 @entity0 with a cutoff of ACPA greater than 1.6 U/mL and greater than 0.6 U/mL for @entity6 @entity0 .

title: Factors Associated with @entity3 in XXXX and Other Connective Tissue Diseases: A Retrospective Study From a Southern Chinese Population.

answer: @entity1


abstract: OBJECTIVES: This study aims to review flexion type supracondylar humerus @entity1 in @entity0 and treatment options. @entity0 AND METHODS: Forty-seven @entity0 (26 males, 21 females; mean age 8.6  3.2 years; range 4 to 15 years) who admitted to and were hospitalized in a pediatric orthopedics clinic between January 2002 and January 2014 due to flexion type supracondylar humerus @entity1 were included in this retrospective study. @entity1 were classified according to Wilkins modification of Gartland system. Closed reduction and percutaneous pinning (CRPP) were administered in all @entity0 with type 2 and 3 @entity1 . An overhead traction or open reduction was applied when closed reduction could not be achieved with three manipulations. @entity0 were evaluated clinically and radiologically. The results were graded according to Flynn criteria. RESULTS: Four @entity0 with type 1 @entity1 were treated conservatively. Of the remaining @entity0 , we were able to perform CRPP successfully in 36 (83.7%). While six @entity0 (14%) were treated with open reduction and internal fixation, one @entity0 (2.1%) was treated with overhead traction. The results were excellent or good in 44 @entity0 (93.7%). CONCLUSION: Compared with extension type @entity1 , these @entity1 are seen in older @entity0 and are rarer. One should be prepared to perform open reduction especially for type 3 @entity1 . In our study, results of @entity0 with type 3 @entity1 treated with CRPP were superior.

title: Flexion type supracondylar humerus XXXX : 12 year experience of a pediatric orthopedics clinic.

answer: @entity1


abstract: During conventional reconstruction of the auricle in @entity0 with @entity2 , simply separating the auricle from the mastoid region with a full-thickness skin graft usually fails to create firm elevation and sufficient projection. To achieve frontal symmetry is difficult, and sometimes the normal auricle needs to be set back. We reconstructed the auricle in @entity0 with @entity2 in two major stages using a modified Nagata's method. Using a wide W-incision skin flap, the first stage includes implantation of a cartilage framework and transposition of the ear lobule. Our modification lies in the second stage. Instead of using the superficial temporoparietal fascial flap, we elevated a @entity1 from the mastoid region, turning it over to wrap an autogenous costal-cartilage wedge, and covered it with a full-thickness skin graft. Between June 1996 and May 1999, eight @entity0 underwent this operation. All the fascial flaps and overlying full-thickness skin grafts survived well. The advantages of our technique include firm elevation, good frontal projection and a natural appearance of the posterior aspect of the ear. Additionally, by using this fast and practical procedure, we avoid creating additional scars on the scalp and preserve the superficial temporoparietal fascia and superficial temporal vessels.

title: Firm elevation of the auricle in reconstruction of @entity2 with a XXXX wrapping an autogenous cartilage wedge.

answer: @entity1


abstract: OBJECTIVE: To determine the feasibility of standardized surveillance of @entity3 ( @entity3 ) in The Netherlands, using local data on @entity0 with @entity3 collected by infection control practitioners (ICPs) and denominator data on all @entity0 under surveillance obtained from the Dutch National Medical Registry (LMR). DESIGN: A prospective, multicenter study. SETTING: Eight hospitals in the Utrecht region, and the National Institute of Public Health and the Environment. @entity0 : ICPs traced @entity3 in gynecological and orthopedic @entity0 for 9 to 16 months. Denominator data on all @entity0 under surveillance were obtained from the LMR. RESULTS: Data from 8,922 @entity0 were collected; the ICPs registered 470 @entity0 with 526 @entity3 . Overall, the @entity3 incidence was 5.9 per 100 @entity0 , or 6.3 per 1,000 @entity0 days. @entity2 ( @entity2 ) were most frequent (3.3%), followed by @entity4 ( @entity4 ; 2.0%) and @entity1 (0.12%). The incidence of both @entity4 and @entity2 differed markedly between hospitals, only partially on account of differences in @entity0 mix (age, type of operations), antibiotic prophylaxis, and intensity of tracing methods for @entity3 . Delay in the availability of denominator data hampered the timely feedback of incidence figures. CONCLUSIONS: Surveillance of @entity3 in a network of sentinel hospitals offered valuable information on the occurrence of @entity3 and on factors influencing the incidence of @entity3 . It revealed situations in which both @entity3 surveillance and infection control methods in individual hospitals should be improved. Obtaining denominator data on all @entity0 from electronically registered @entity0 discharge data greatly reduces the workload of ICPs and enables surveillance on all types of @entity3 (all body sites and all pathogens). For timely feedback, numerator and denominator data within hospitals must be linked.

title: Sentinel system for XXXX in The Netherlands: a pilot study.

answer: @entity3


abstract: BACKGROUND: Few studies have examined samples of @entity0 with cannabis-induced @entity2 . AIMS: To establish whether cannabis-induced @entity3 are followed by development of persistent @entity2 conditions, and the timing of their onset. METHOD: Data on @entity0 treated for cannabis-induced @entity2 between 1994 and 1999 were extracted from the Danish Psychiatric Central Register. Those previously treated for any @entity2 were excluded. The remaining 535 @entity0 were followed for at least 3 years. In a separate analysis, the sample was compared with @entity0 referred for @entity1 -spectrum disorders for the first time, but who had no history of cannabis-induced @entity2 . RESULTS: @entity1 -spectrum disorders were diagnosed in 44.5% of the sample. New @entity2 episodes of any type were diagnosed in 77.2%. Male gender and young age were associated with increased risk. Development of @entity1 -spectrum disorders was often delayed, and 47.1% of @entity0 received a diagnosis more than a year after seeking treatment for a cannabis-induced @entity2 . The @entity0 developed @entity1 at an earlier age than @entity0 in the comparison group (males, 24.6 v. 30.7 years, females, 28.9 v. 33.1 years). CONCLUSIONS: Cannabis-induced @entity3 are of great clinical and prognostic importance.

title: Cannabis-induced @entity2 and subsequent XXXX -spectrum disorders: follow-up study of 535 incident cases.

answer: @entity1


abstract: UNASSIGNED: Epithelial to mesenchymal transition (EMT) is an essential differentiation program during tissue morphogenesis and remodeling. EMT is induced by soluble @entity2 ( @entity2 ) family members, and restricted by vascular endothelial growth factor family members. While many downstream molecular regulators of EMT have been identified, these have been largely evaluated individually without considering potential crosstalk. In this study, we created an ensemble of dynamic mathematical models describing @entity2 induced EMT to better understand the operational hierarchy of this complex molecular program. We used ordinary differential equations (ODEs) to describe the transcriptional and post-translational regulatory events driving EMT. Model parameters were estimated from multiple data sets using multiobjective optimization, in combination with cross-validation. @entity2 exposure drove the model population toward a mesenchymal phenotype, while an epithelial phenotype was enhanced following @entity0 ( @entity0 ) exposure. Simulations predicted that the transcription factors phosphorylated @entity3 and NFAT were master regulators promoting or inhibiting EMT, respectively. Surprisingly, simulations also predicted that a cellular population could exhibit phenotypic heterogeneity (characterized by a significant fraction of the population with both high epithelial and mesenchymal marker expression) if treated simultaneously with @entity2 and @entity0 . We tested this prediction experimentally in both MCF10A and DLD1 cells and found that upwards of 45% of the cellular population acquired this hybrid state in the presence of both @entity2 and @entity0 . We experimentally validated the predicted NFAT/ @entity3 signaling axis for each phenotype response. Lastly, we found that cells in the hybrid state had significantly different functional behavior when compared to @entity0 or @entity2 treatment alone. Together, these results establish a predictive mechanistic model of EMT susceptibility, and potentially reveal a novel signaling axis which regulates @entity1 progression through an EMT versus tubulogenesis response.

title: Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated XXXX .

answer: @entity3


abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is well-established as a potentially curative treatment for @entity0 who have chronic @entity4 . The success of @entity3 and other @entity2 kinase inhibitors (TKI) as initial therapy has changed the treatment paradigm for this disease. Allogeneic hematopoietic transplants are now reserved for @entity0 whose disease does not respond optimally to TKI treatment. @entity0 whose disease does not have an optimal response to @entity3 may respond to a second-generation TKI, @entity5 or @entity6 , and many achieve major or complete molecular and cytogenetic responses. The indication for allogeneic HSCT versus continued second-line therapy is not well-defined and is the subject of ongoing study. There has been continued progress in reducing the @entity1 and risks of HSCT with development of reduced-intensity regimens; transplants can be routinely performed in @entity0 up to the age of 75 years who are in fair general medical condition. Transplantation results from unrelated donors have improved, with survival rates similar that achieved with matched siblings. Results with haploidentical and cord blood transplants have markedly improved, and should be considered for @entity0 lacking a matched donor. Allogeneic hematopoietic transplants have the best chance to be curative in @entity0 with chronic phase that is under hematologic control with 80% disease-free survival; @entity0 progressing to the accelerated phase or blast crisis have a much poorer prognosis. Thus, HSCT should be considered for @entity0 with @entity3 failure. @entity0 receiving second-line TKI therapy must be closely monitored and referred for transplantation if a complete cytogenetic response and major molecular response is not achieved. HSCT should be performed if feasible in @entity0 without a continued response to TKI treatment.

title: Allogeneic stem cell transplantation for chronic XXXX resistant to @entity2 kinase inhibitors.

answer: @entity4


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a rare @entity1 characterized by the development of multiple @entity4 in the gastrointestinal tract. @entity4 are most common in the colorectum (98  % of @entity0 ) and the stomach (14  %). Causative mutations for @entity3 have been identified in two genes to date, @entity8 and @entity9 . @entity8 mutations are associated with a higher incidence of @entity10 . In this case report, we describe two @entity0 with massive @entity10 associated with a @entity8 mutation. Both presented with @entity2 and both had @entity7 . Initial endoscopic findings revealed giant rugal folds suggestive of M  n  trier disease. However, as other possible gastropathies could not be differentiated on the basis of histology, a definitive diagnosis of @entity3 required additional mutation analysis. In @entity0 with @entity6 predominant in or limited to the stomach, establishing a diagnosis based solely on the pathological features of @entity4 can be challenging due to difficulties in differentiating @entity3 from other @entity5 . Mutation analysis should be considered early in the diagnostic process in cases of suspected @entity6 , thus facilitating rapid diagnosis and adequate follow-up.

title: Massive @entity10 associated with a germline XXXX gene mutation.

answer: @entity8


abstract: BACKGROUND: The "gold standard" and only accurate method for diagnosing @entity1 is by esophagogastroduodenoscopy with biopsy. We evaluated the ability of high-resolution endoluminal sonography (HRES) to detect the mucosal changes in @entity1 . METHODS: Seventeen @entity0 with documented Barrett's and 12 normal controls underwent endoscopy with HRES examination using a 20 MHz ultrasound transducer to evaluate for mucosal changes. HRES examinations were videotaped then reviewed by an unblinded investigator to identify criteria possibly diagnostic of Barrett's and then by a blinded investigator to test the validity of these criteria. Barrett's was diagnosed by HRES if the second hypoechoic layer appeared thicker than the first @entity3 . Normal mucosa was defined as having a pencil-thin second hypoechoic layer on HRES. Measurements of the second hypoechoic layer were made using a computer and compared in @entity0 with Barrett's and @entity0 with normal esophagus. RESULTS: All 17 @entity0 with Barrett's were correctly identified by HRES (sensitivity 100%). Ten of 12 controls were correctly identified as normal (specificity 86%). There was good correlation between HRES and pathologic diagnoses (r 0.86). The second hypoechoic layer was significantly thicker in Barrett's @entity0 than in normal controls (p < .001). CONCLUSIONS: HRES is a sensitive new method for identifying @entity1 . However, @entity2 could not be identified by HRES in this study.

title: High-resolution endoluminal sonography is a sensitive modality for the identification of XXXX .

answer: @entity1


abstract: OBJECTIVE: Early identification of causative microorganism(s) in @entity0 with severe @entity3 is crucial to optimize antimicrobial use and @entity0 survival. However, current culture-based pathogen identification is slow and unreliable such that broad-spectrum antibiotics are often used to insure coverage of all potential organisms, carrying risks of overtreatment, @entity2 , and selection of multidrug-resistant bacteria. We compared the results obtained using a novel, culture-independent polymerase chain reaction/electrospray ionization-mass spectrometry technology with those obtained by standard microbiological testing and evaluated the potential clinical implications of this technique. DESIGN: Observational study. SETTING: Nine ICUs in six European countries. @entity0 : @entity0 admitted between October 2013 and June 2014 with suspected or proven @entity3 , @entity1 , or sterile fluid and tissue @entity3 were considered for inclusion. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We tested 616 @entity3 , 185 @entity1 , and 110 sterile fluid and tissue specimens from 529 @entity0 . From the 616 @entity3 samples, polymerase chain reaction/electrospray ionization-mass spectrometry identified a pathogen in 228 cases (37%) and culture in just 68 (11%). Culture was positive and polymerase chain reaction/electrospray ionization-mass spectrometry negative in 13 cases, and both were negative in 384 cases, giving polymerase chain reaction/electrospray ionization-mass spectrometry a sensitivity of 81%, specificity of 69%, and negative predictive value of 97% at 6 hours from sample acquisition. The distribution of organisms was similar with both techniques. Similar observations were made for @entity1 and sterile fluid and tissue specimens. Independent clinical analysis of results suggested that polymerase chain reaction/electrospray ionization-mass spectrometry technology could potentially have resulted in altered treatment in up to 57% of @entity0 . CONCLUSIONS: Polymerase chain reaction/electrospray ionization-mass spectrometry provides rapid pathogen identification in critically ill @entity0 . The ability to rule out @entity3 within 6 hours has potential clinical and economic benefits.

title: Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, XXXX , and @entity3 .

answer: @entity1


abstract: UNASSIGNED: MiRNAs are small, non-protein-coding RNA molecules that regulate gene expression either by post-transcriptionally suppressing mRNA translation or by mRNA degradation. We examine differentially expressed miRNAs in @entity1 , @entity3 and normal colonic mucosa. Data come from population-based studies of @entity1 conducted in Utah and the Kaiser Permanente Medical Care Program. A total of 1893 @entity2 /normal-paired samples and 290 @entity3 tissue samples were run on the Agilent @entity0 miRNA Microarray V19.0 which contained 2006 miRNAs. We tested for significant differences in miRNA expression between paired @entity2 / @entity3 /normal colonic tissue samples. Fewer than 600 miRNAs were expressed in >80% of @entity0 for colonic tissue; of these 86.5% were statistically differentially expressed between @entity2 and normal colonic mucosa using a false discovery rate of 0.05. Roughly half of these differentially expressed miRNAs showed a progression in levels of expression from normal to @entity4 tissue. Other miRNAs appeared to be altered at the normal to @entity3 stage, while others were only altered at the @entity4 stage or only at the normal to @entity2 stage. Evaluation of the Agilent platform showed a high degree of repeatability (r = 0.98) and reasonable agreement with the NanoString platform. Our data suggest that miRNAs are highly dysregulated in colorectal tissue among individuals with @entity1 ; the pattern of disruption varies by miRNA as tissue progresses from normal to @entity4 .

title: MicroRNA profiles in XXXX , @entity3 and normal colonic mucosa: variations in miRNA expression and disease progression.

answer: @entity1


abstract: AIMS: Ionic perturbation in vascular smooth muscle cells contributes to @entity5 in the setting of @entity2 , but the role of transient receptor potential (TRP) channel superfamily remains unknown. The present study was conducted to define the contribution of TRP channels to @entity5 . METHODS AND RESULTS: By integrating quantitative PCR, western blotting, patch clamping, and @entity3 imaging, we identified TRP channel, subfamily canonical, member 3 ( @entity10 ) as the channel subtype most considerably elevated in basilar arteries of two-kidney, two-clip @entity1 -prone @entity2 @entity0 . Importantly, administration of @entity7 3 (Pyr3), a @entity10 channel blocker, @entity4 . During @entity2 , @entity6 ( @entity6 ) was transactivated, as evidenced by marked @entity6 phosphorylation, increased pro- @entity9 shedding, and elevated activity of @entity8 ( @entity9 sheddase). @entity8 activity was increased owing to enhanced activation rather than elevated expression. Remarkably, Pyr3 treatment suppressed @entity6 transactivation in @entity2 . In proliferating basilar artery smooth muscle cells or basilar arteries of @entity2 @entity0 , co-immunoprecipitation assay revealed an interaction between @entity10 and @entity8 upon Ang II stimulation. CONCLUSION: Collectively, we demonstrated that enhanced @entity6 transactivation, due to increased @entity10 expression and functional coupling of @entity10 / @entity8 , resulted in @entity5 . Therefore, @entity10 -induced @entity6 transactivation may be therapeutically exploited to prevent @entity2 -induced @entity5 .

title: @entity10 channel confers XXXX during @entity2 via transactivation of EGF receptor signalling.

answer: @entity5


abstract: UNASSIGNED: Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to @entity5 with challenges to survival and reproduction. @entity1 hormones actively participate in neuroplasticity and @entity0 from both gonads and neurons seem to be involved in behavioral modulation in primates. Indirect evidence suggests the participation of sexual @entity0 in dimorphism of the stress response in @entity4 . This species is an important experimental model in psychiatry, and we found a dual profile for @entity2 in the transition from juvenile to subadult, with females showing higher levels. Immature males and females at 6 and 9   months of age moved alone from the family group to a new cage, over a 21-day period, expressed distinct patterns of @entity2 variation with respect to range and duration of response. Additional evidence showed that at 12   months of age, males and females buffered the @entity3 during chronic stress. Moreover, chronic stressed juvenile marmoset males showed better cognitive performance in working memory tests and motivation when compared to those submitted to short-term stress living in family groups. Thus, as @entity2 profile seems to be sexually dimorphic before adulthood, age and sex are critical variables to consider in approaches that require immature marmosets in their experimental protocols. Moreover, available cognitive tests should be scrutinized to allow better investigation of cognitive traits in this species.

title: Endocrine and Cognitive Adaptations to XXXX with Stress in Immature @entity4 ( @entity4 ): Sex and Age Matter.

answer: @entity5


abstract: To assess the in vivo sensitivity of @entity2 to @entity3 and @entity1 in a hyperendemic area of southern Viet @entity5 , we studied 41 @entity0 and 21 adults from a remote commune who had uncomplicated @entity4 without previous treatment. @entity0 were randomly allocated to @entity1 (4 mg/kg on day 0 and 2 mg/kg on days 1-4) or @entity3 (10 mg/kg followed by 5 mg/kg at 6 h). Serial assessments were performed over 28 days. Of 31 @entity0 allocated @entity1 , nine (29%) redeveloped parasitaemia during follow-up compared with 23% (seven of 30) who received @entity3 . Of the 41 @entity0 , 15 (37%) had recrudescence/re-infection compared with only one of 20 adults (5%; p < 0.001). Significantly more @entity0 than adults failed on @entity3 treatment (37% vs 0%; p = 0.021) and one case showed RIII resistance. There was no significant difference in the case of @entity1 . In regression analysis, parasitaemia was an independent predictor of recrudescence/re-infection after @entity3 (p = 0.02). These data support the use of combination therapy such as @entity1 plus @entity3 for @entity4 in a hyperendemic area of Viet @entity5 . Primarily because of their greater parasite densities, @entity0 should be given higher doses of @entity3 (e.g. 25 mg/kg).

title: Treatment of @entity4 in Vietnamese XXXX : the need for combination therapy and optimized dosage regimens.

answer: @entity0


abstract: BACKGROUND/AIM: @entity5 ( @entity5 ) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate @entity5 receptor expression and release the truncated @entity6 (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in @entity0 with @entity2 and to verify whether TNGFR can be used as a biomarker of @entity2 . MATERIALS AND METHODS: Twelve @entity0 with @entity2 and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected and the concentrations of TNGFR in the urine samples were measured by fluoroimmunoassay. RESULTS: The mean levels of TNGFR in the urine samples of the healthy control subjects and the @entity0 with @entity2 were 164    23 and 341    66 ng / mg @entity3 respectively. A positive relationship was found between the levels of TNGFR in different ages of both control and @entity0 subgroups. This is consistent with the previous observations that pathological condition may stimulate the @entity5 receptor expression. CONCLUSION: These findings might be of assistance to evaluate the development of the @entity4 associated with @entity1 and other age-associated diseases.

title: @entity5 receptors in XXXX .

answer: @entity2


abstract: PURPOSE: To determine the response, failure-free survival (FFS), and overall survival rates and @entity1 of rituximab plus an intense chemotherapy regimen in @entity0 with previously untreated aggressive @entity6 ( @entity6 ). @entity0 AND METHODS: This was a prospective phase II trial of rituximab plus fractionated @entity5 , @entity8 , @entity4 , and @entity3 ( @entity11 ; considered one cycle) alternating every 21 days with rituximab plus high-dose @entity7 - @entity10 (considered one cycle) for a total of six to eight cycles. RESULTS: Of 97 assessable @entity0 , 97% responded, and 87% achieved a complete response (CR) or unconfirmed CR. With a median follow-up time of 40 months, the 3-year FFS and overall survival rates were 64% and 82%, respectively, without a plateau in the curves. For the subgroup of @entity0 < or = 65 years of age, the 3-year FFS rate was 73%. The principal @entity1 was hematologic. Five @entity0 died from acute @entity1 . Four @entity0 developed treatment-related @entity9 / @entity12 , and three @entity0 died while in remission from @entity6 . A total of eight treatment-related @entity2 (8%) occurred. CONCLUSION: Rituximab plus @entity11 alternating with rituximab plus high-dose @entity7 and @entity10 is effective in untreated aggressive @entity6 . @entity1 is significant but expected. Because of the shorter FFS concurrent with significant @entity1 in @entity0 more than 65 years of age, this regimen is not recommended as standard therapy for this age subgroup. Larger prospective randomized studies are needed to define the role of this regimen in the treatment of @entity6 @entity0 compared with existing and new treatment modalities.

title: High rate of durable remissions after treatment of newly diagnosed aggressive @entity6 with rituximab plus XXXX alternating with rituximab plus high-dose @entity7 and @entity10 .

answer: @entity11


abstract: BACKGROUND: Extramedullary plasmacytoma of the retroperitoneum is rare. Furthermore, plasmacytoma with anaplastic features can be confused with high grade @entity1 clinically and histologically, particularly when the initial immunohistochemical @entity0 markers are negative. However, paying attention to cytologic imprint smears can give valuable clues to the correct diagnosis. CASE: A 73-year-old male was admitted to our hospital with a recent history of @entity3 . Abdominal computed tomography revealed a large retroperitoneal mass (6.8 x 5.1 cm). The initial pathologic evaluation revealed a high grade pleomorphic @entity0 that failed to express multiple epithelial, mesenchymal, lymphoid and @entity2 immunohistochemical markers. Subsequent fresh tissue evaluation with touch imprints and immunophenotypic characterization confirmed the plasma cell origin of the @entity0 . Thorough retrospective review of the touch imprint smears clearly showed the plasmacytic cytologic features. Features of multiple @entity4 were essentially absent. CONCLUSION: Performing cytologic imprint smears on fresh tissue material may help in making the correct diagnosis and is highly recommended.

title: Retroperitoneal extramedullary anaplastic plasmacytoma masquerading as XXXX : Report of a case with an unusual presentation and imprint smears.

answer: @entity1


abstract: BACKGROUND: Circulating endothelial cells (CECs) have been studied as a biomarker for @entity2 progression and monitoring therapeutic effects. The CellSearch system is a semi-automated system that allows standardised analysis of CECs. This study assessed the clinical implications of CECs determined by the CellSearch system in @entity0 @entity1 . METHODS: Seventy-six consecutive @entity0 @entity1 (53 operable and 23 metastatic or recurrent) were enrolled for the study. Thirty-five @entity1 with operable @entity0 received preoperative chemotherapy with a regimen based on @entity6 and/or @entity5 . CECs are defined as CD146(+)CD105(+) @entity3 (-)DAPI(+) cells in the system. @entity4 expression was examined using the additional channel in the system. RESULTS: A majority (4539 of 5183 cells, 88%) of CECs from @entity1 with operable @entity0 were @entity4 -positive. @entity2 showed higher baseline CEC and @entity4 (+)CEC counts than the other types (P=0.0387 and 0.0377, respectively). Low baseline CEC and @entity4 (+)CEC counts, and a low @entity4 positive rate were associated with pathological complete response (pCR) of preoperative chemotherapy in @entity1 with primary @entity0 (P=0.046, 0.027 and 0.01, respectively). In multivariate analyses, the @entity4 positive rate was significant for pCR (P=0.021). During preoperative chemotherapy, CEC and @entity4 (+)CEC counts before each cycle of chemotherapy increased with @entity5 -based regimens (P=0.0018 and 0.0008, respectively) but not with @entity6 -based regimens. CONCLUSIONS: Baseline CEC, in particular @entity4 (+)CEC, counts and the @entity4 positive rate might be useful for the prediction of treatment response of preoperative chemotherapy in @entity1 with operable @entity0 .

title: Determining circulating endothelial cells using CellSearch system during preoperative systemic chemotherapy in XXXX @entity1 .

answer: @entity0


abstract: Cell based therapy has been shown to attenuate @entity0 after @entity1 ( @entity1 ) in different acute and chronic animal models. It has been further shown that stromal-cell derived factor-1a (SDF-1a) facilitates proliferation and migration of endogenous progenitor cells into injured tissue. The aim of the present study was to investigate the role of exogenously applied and endogenously mobilized cells in a regenerative strategy for @entity1 therapy. Lentivirally SDF-1a-infected endothelial progenitor cells (EPCs) were injected after 90  min. of ligation and reperfusion of the left anterior descending artery (LAD) intramyocardial and intracoronary using a new rodent catheter system. Eight weeks after transplantation, echocardiography and isolated heart studies revealed a significant improvement of LV function after intramyocardial application of lentiviral with @entity5 infected EPCs compared to medium control. Intracoronary application of cells did not lead to significant differences compared to medium injected control hearts. Histology showed a significantly elevated rate of apoptotic cells and augmented proliferation after transplantation of EPCs and EPCs  +  SDF-1a in infarcted @entity3 . In addition, a significant increased density of @entity6 (+) vessel structures, a lower collagen content and higher numbers of inflammatory cells after transplantation of @entity5 transgenic cells were detectable. Intramyocardial application of lentiviral-infected EPCs is associated with a significant improvement of myocardial function after @entity2 , in contrast to an intracoronary application. Histological results revealed a significant @entity4 , lower collagen content, higher numbers of inflammatory cells and remarkable alterations of apoptotic/proliferative processes in infarcted areas after cell transplantation.

title: Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing XXXX in a rat model.

answer: @entity5


abstract: BACKGROUND: This phase III trial compared the efficacy and safety of @entity1 plus @entity3 (GemCap) versus single-agent @entity1 ( @entity7 ) in advanced @entity4 as first-line chemotherapy. METHODS: A total of 214 advanced @entity4 @entity0 were enrolled from 16 hospitals in South Korea between 2007 and 2011. @entity0 were randomly assigned to receive GemCap (oral @entity3 1660mg/m plus @entity7 1000mg/m by 30-minute intravenous infusion weekly for 3 weeks followed by a 1-week break every 4 weeks) or @entity7 (by 30-minute intravenous infusion weekly for 3 weeks every 4 weeks). RESULTS: Median @entity5 ( @entity5 ) time, the primary end point, was 10.3 and 7.5 months in the GemCap and @entity7 arms, respectively (P=0.06). Progression-free survival was 6.2 and 5.3 months in the GemCap and @entity7 arms, respectively (P=0.08). GemCap significantly improved overall response rate compared with @entity7 alone (43.7% vs 17.6%; P=0.001). Overall frequency of grade 3 or 4 @entity2 was similar in each group. @entity6 was the most frequent grade 3 or 4 @entity2 in both groups. CONCLUSION: GemCap failed to improve @entity5 at a statistically significant level compared to @entity7 treatment. This study showed a trend toward improved @entity5 compared to @entity7 alone. GemCap and @entity7 both exhibited similar safety profiles.

title: A randomized, multicenter, phase III study of @entity1 combined with XXXX versus @entity1 alone as first-line chemotherapy for advanced @entity4 in South Korea.

answer: @entity3


abstract: INTRODUCTION: @entity12 ( @entity13 ) is an oral alkylating agent that has been used over the past 8  years to treat aggressive @entity9 resistant to conventional therapy. To date, only 25 @entity0 treated with @entity13 for ACTH producing @entity9 (14 @entity5 and 11 @entity3 ) have been reported. MATERIALS AND METHODS: We present  a retrospective review of the medical records of three @entity0 with aggressive ACTH producing @entity5 treated with @entity13 . In the three cases there was evidence of progression to conventional therapy before starting @entity13 . We used the conventional scheme for the treatment of @entity2 until completing 7, 12 and 6 cycles respectively. Reduction in @entity1 size was evident after the 3rd, 5th and 4th cycle of @entity13 and progression free survival was 25, 19 and more than 12  months in the three @entity0 respectively. Improvement of the ocular and visual symptoms was evident after the 4th cycle of treatment in all cases. Normalization of urinary free @entity7 levels was achieved after the 3rd and 9th cycle in the two cases with @entity6 . Two of the three @entity0 received a second course of treatment when the disease progressed but it did not stop @entity1 progression. The principal side effects were G3 @entity11 , G1 and G2 @entity8 , @entity14 , @entity10 and @entity4 . CONCLUSION: The treatment with @entity13 is effective and safe in @entity0 with aggressive @entity1 resistant to conventional therapy. Nevertheless once the disease progresses, a second course of treatment does not seem to be effective.

title: XXXX for aggressive ACTH @entity9 : failure of a second course of treatment.

answer: @entity12


abstract: INTRODUCTION: @entity3 ( @entity3 ) is the most common @entity1 in adult kidneys. One of the most important unmet medical needs in @entity3 is a prognostic biomarker to enable identification of @entity0 at high risk of relapse after nephrectomy. New biomarkers can help improve diagnosis and hence the management of @entity0 with @entity2 . Thus, this systematic review aims to clarify the prognostic and diagnostic accuracy of @entity5 in @entity0 with @entity3 . METHODS AND ANALYSIS: We will include observational studies evaluating the diagnostic and prognostic roles of @entity5 in @entity0 with @entity2 . The index test and reference standards should ideally be performed on all @entity0 . We will search PubMed, SCOPUS and ISI Web of Science with no restriction of language. The outcome will be survival measures in adult @entity0 with @entity3 . Study selection and data extraction will be performed by two independent reviewers. QUADAS-1 will be used to assess study quality. Publication bias and data synthesis will be assessed by funnel plots and Begg's and Egger's tests using Stata software V.11.1. ETHICS AND DISSEMINATION: No ethical issues are predicted. These findings will be published in a peer-reviewed journal and presented at national and international conferences. @entity4 REGISTRATION NUMBER: This systematic review protocol is registered in the PROSPERO International Prospective Register of Systematic Reviews, registration number CRD42015025001.

title: Diagnostic and prognostic accuracy of XXXX in @entity3 : a systematic review protocol.

answer: @entity5


abstract: @entity1 were fed diets containing 7.5% added @entity6 , @entity8 , or @entity10 for 21 days. In addition, 50 microCi/kg cerium-141 was included for the last 10 days on experimental diets as an unabsorbed reference substance. In the rumen dietary @entity4 were approximately 50% hydrolyzed, and hydrogenation resulted in saturation of the free @entity2 fraction. Some net synthesis of phospholipids, presumably microbial phospholipids, occurred in the rumen. In the intestine immediately distal to the pylorus, extensive secretion of @entity7 , @entity0 , phospholipids, @entity4 , free @entity5 , and lipase occurred. This resulted in doubling of @entity2 fluxes through the duodenum. These endogenous secretions were reabsorbed rapidly however, with the major site of lipid and @entity9 absorption in the region .6 to 4 m distal to the pylorus. Additional but less absorption occurred in the more distal segments of the small intestine. Overall absorption of @entity6 , @entity8 , and @entity10 supplements was in the range 60 to 70%, and no differences were apparent between fats. @entity3 were over 90% absorbed as compared with 55 to 65% for @entity5 . No significant effect of any of the supplements was observed on ruminal total volatile @entity5 , ratios of volatile @entity5 , or on overall cellulose or caloric digestion.

title: Digestion and absorption of lipids and XXXX in @entity1 fed @entity6 , @entity8 , or @entity10 .

answer: @entity7


abstract: We evaluated the @entity8 radical (* @entity4 ) scavenging action of nonsteroidal anti-inflammatory drugs (NSAIDs), @entity12 (SA), @entity7 and @entity13 in Fenton's reaction and their neuroprotective effects in @entity10 ( @entity11 )-induced striatal @entity3 (DA) depletion in @entity0 . @entity5 hydroxylation procedure employing HPLC-electrochemistry was used to assay formation of * @entity4 in Fenton's reaction in test tubes. While SA dose- and time-dependently hydroxylated itself and inactivated * @entity4 , @entity13 (up to 10 mM) showed no effect on * @entity4 formation and @entity7 caused a reduction in * @entity4 generation only at high doses (100 microM-10 mM). Administration of the non-selective cyclooxygenase (COX) inhibitor, SA (50, 100 mg/kg, i.p.) significantly attenuated striatal DA depletion caused by intrastriatal infusion of @entity11 (100 nmol in 4 microl). Treatment with another nonselective, reversible COX inhibitor, @entity7 (5, 10 mg/kg) did not protect against @entity11 -induced DA depletion. The selective @entity9 inhibitor, @entity13 (2.5-50 mg/kg) treatment exacerbated @entity11 -induced decrease in DA. Failure of @entity13 or @entity7 to render protection in animals against @entity11 -induced DA depletion indicates absence of @entity6 involvement in @entity11 action. These results also suggest that the neuroprotective ability of SA is independent of @entity6 mediation. A relationship between inactivation of * @entity4 by SA and its ability to protect DA depletion in the striatum caused by @entity11 indicates a direct involvement of * @entity4 in the action of this neurotoxin. The present study establishes potent neuroprotective activity of SA and suggests the use of @entity1 in adjuvant therapy in @entity2 .

title: Non-steroidal anti-inflammatory drug XXXX , but not @entity7 or @entity13 , protects against @entity10 -induced dopaminergic neurotoxicity in @entity0 .

answer: @entity12


abstract: 1. Although @entity7 is a feature of @entity3 and @entity4 , the extent and nature of mast cell activation in @entity6 have not been clearly established. 2. We have investigated the levels of mast cell tryptase and @entity2 and also of eosinophil cationic protein in synovial fluid collected from 31 @entity0 with @entity3 , 14 with seronegative @entity5 and nine with @entity4 . Two RIAs for tryptase were employed: one with monoclonal antibody AA5, which was found to bind equally well to both alpha and beta isoforms on Western blots of the recombinant enzyme, and the other with antibody G5, which recognizes predominantly beta-tryptase. 3. alpha-Tryptase, which is likely to be released constitutively from mast cells, appeared to be the major form in synovial fluid, as the assay with antibody AA5 detected appreciably more tryptase than that with antibody G5. beta-Tryptase, which is released on anaphylactic activation of mast cells, was detected in 14 out of 45 synovial fluid samples studied, with concentrations of up to 12 micrograms/l measured by the G5 assay. The apparent levels of beta-tryptase, but not of alpha-tryptase, were closely correlated with those of @entity2 in the synovial fluid. @entity0 with @entity4 appeared to have a greater proportion of beta-tryptase in the synovial fluid than those with @entity3 , as well as higher concentrations of @entity2 . Eosinophil cationic protein was present at high levels in the synovial fluid, although eosinophil numbers were low, and its concentrations were not correlated with the concentrations of the mast cell products. 4. These data suggest that anaphylactic degranulation of mast cells may have occurred to a greater extent in @entity4 than in @entity3 , despite the relative lack of @entity1 in @entity4 . Although the eosinophil cationic protein detected may not reflect eosinophilic inflammation in the joint, the presence in synovial fluid of tryptase of both major forms, and of @entity2 , appears to indicate that mast cell products are secreted constitutively, as well as by processes of anaphylactic degranulation in @entity3 , seronegative @entity5 and @entity4 .

title: Mast cell activation in arthritis: detection of alpha- and beta-tryptase, XXXX and eosinophil cationic protein in synovial fluid.

answer: @entity2


abstract: UNASSIGNED: Explosive blast-related @entity3 are one of the hallmark @entity3 of veterans returning from recent wars, but the effects of a blast overpressure on the brain are poorly understood. In this study, we used in vivo diffusion kurtosis imaging (DKI) and proton magnetic resonance spectroscopy (MRS) to investigate tissue microstructure and metabolic changes in a novel, direct cranial blast @entity4 (dc-bTBI) @entity0 model. Imaging was performed on @entity0 before injury and 1, 7, 14 and 28 days after blast exposure (~517 kPa peak overpressure to the dorsum of the head). No @entity2 were visible on conventional T2-weighted MRI, but microstructural and metabolic changes were observed with DKI and proton MRS, respectively. Increased mean kurtosis, which peaked at 21 days post injury, was observed in the hippocampus and the internal capsule. Concomitant increases in @entity11 ( @entity12 ) and @entity6 ( @entity9 ) were also observed in the hippocampus, while early changes at 1 day in the @entity8 ( @entity10 ) were observed in the internal capsule, all indicating @entity1 in these regions. Neurofunctional testing on a separate but similarly treated group of @entity0 showed early disturbances in vestibulomotor functions (days 1-14), which were associated with imaging changes in the internal capsule. Delayed @entity7 and in rapid learning, as assessed by Morris Water Maze paradigms (days 14-19), were associated with delayed changes in the hippocampus. Significant microglial activation and @entity5 were observed at 28 days in the hippocampus. Overall, our findings indicate delayed neurofunctional and pathological abnormalities following dc-bTBI that are silent on conventional T2-weighted imaging, but are detectable using DKI and proton MRS.

title: Changes in Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy in a Direct Cranial Blast XXXX (dc-bTBI) Model.

answer: @entity4


abstract: INTRODUCTION: In @entity0 with non-metastatic @entity1 ( @entity1 ) fit for curative therapy, a multidisciplinary approach consisting is recommended. This approach includes local treatment (usually radical cystectomy), ideally combined with neoadjuvant chemotherapy (NACT). Despite a survival benefit with NACT, uptake remains low. We assessed NACT consultation in Alberta and examined associative factors, as well as the relationship to survival. METHODS: @entity0 with @entity1 were identified through the Alberta Cancer Registry. Demographic and clinicopathologic information was collected from electronic medical records between 2007 and 2011. In addition to descriptive statistics, logistic regression was used to determine factors associated with receiving NACT consultation. Overall survival was described using a Kaplan-Meier estimate. RESULTS: Of the 315 radical cystectomy @entity0 , 140 (45.1%, 95% confidence interval [CI] 39.5, 50.8) received NACT consultation. @entity0 >= 80 years (odds ratio [OR] 0.21, 95% CI 0.08, 0.57, p = 0.002) and those treated in Calgary (OR 0.11, 95% CI 0.05, 0.25, p < 0.001) were less likely to receive NACT consultation. The rate of NACT consultation increased steadily from 2007 to 2011 (OR 1.23, 95% CI 1.04, 1.45 per year of diagnosis, p = 0.018). After a median follow-up of 28.1 months (range: 14.6-50.3), median survival was 54.7 months for @entity0 who received NACT consultation versus 31.2 months for those who did not (p = 0.030). CONCLUSIONS: NACT consultation in @entity0 with @entity1 undergoing radical cystectomy has improved over time; however, regional differences underscore the need for a standardized approach to NACT consultation, including common referral mechanisms.

title: Predictors of referral for neoadjuvant chemotherapy prior to radical cystectomy for XXXX and changes in practice over time.

answer: @entity1


abstract: Light microscopic changes were studied in the dorsal funiculi of spinal cords from @entity1 irradiated (4000 R) at 3 days of age and killed from 9-60 days postirradiation (P-I). The irradiated site was limited to a 5-mm length of mid-thoracic spinal cord (T only) in one group of @entity1 , to a 5-mm length of lumbosacral spinal cord (L only) in a second group, and to 5-mm lengths of both mid-thoracic and lumbosacral spinal cord (T/L) in the third group. Changes in the lumbosacral regions were essentially the same in both L only and T/L irradiated groups. These changes included a decreased neuroglial population and a concurrent state of @entity0 from 9-30 days P-I. In contrast, in the mid-thoracic regions of T only and T/L irradiated groups the decrease in the neuroglial population was obvious only through 13 days P-I, and by 30 days this population resembled that of the controls. The irradiated mid-thoracic areas were hypomyelinated, with the fasciculus gracilis showing a greater degree of @entity0 than the fasciculus cuneatus. By 25 days P-I, myelination appeared to be normal in these areas. Scattered @entity3 were noted in both lumbosacral and mid-thoracic regions, but @entity2 areas occurred only at the lumbosacral level. In general, the mid-thoracic area appeared to be less sensitive to x-radiation at 3 days of age than the lumbosacral area. These data suggest that there may be marked differences in the developmental states of cells at these two levels at 3 days of age.

title: A comparison of histopathologic changes following X-irradiation of mid-thoracic and lumbosacral levels of neonatal XXXX spinal cord.

answer: @entity1


abstract: PURPOSE: This study evaluated the prognostic impact of a novel, simple, and standardized assay for monitoring @entity1 ( @entity1 ) in @entity3 ( @entity3 ). EXPERIMENTAL DESIGN: The expression of seven @entity2 -associated genes ( @entity4 , @entity7 , @entity6 , @entity5 , @entity9 , @entity10 , and @entity8 ) was measured by TaqMan Low Density Arrays in 112 @entity0 and 52 healthy controls. @entity0 were treated according to the multicenter study @entity3 -BFM 2004. Samples were collected prospectively at standard time points. The laboratory that measured @entity1 was blinded to @entity0 outcome. RESULTS: Relapse-free survival (RFS) was 95% (N = 19; SE = 5%) if expression of all genes was down to normal on day 15, 63% (N = 41; SE = 8%) if expression was normalized on day 28, and 38% (N = 21; SE = 11%) in @entity0 who still showed elevated expression on day 28. The prognostic impact of @entity1 remained significant (P = 0.002) when @entity0 were stratified for the @entity3 -BFM 2004 risk group. Multivariate analysis identified the @entity1 risk group and day 28 cytology as the only independent prognostic factors. @entity0 with a cytologic nonremission on day 28, which was confirmed by @entity1 , had a dismal prognosis. Only 1 out of 8 @entity0 survived without relapse. CONCLUSIONS: This novel method of monitoring @entity1 has a strong prognostic impact that is independent from established risk factors in @entity3 . Clin Cancer Res; 21(6); 1353-9.   2014 AACR.

title: Prospective Validation of a New Method of Monitoring Minimal Residual Disease in XXXX .

answer: @entity3


abstract: @entity4 were exposed to @entity16 by inhalation exposure to concentrations of 0, 10, 50, and 250 mg/m3 for 6 hr/day, 5 days/week for 2 years. There were no abnormal clinical signs, body weight changes, or excess mortality in any exposed group. Exposed groups showed slight increases in the incidence of @entity5 , @entity19 , and @entity15 with @entity13 in the anterior nasal cavity. The pulmonary response at 10 mg/m3 satisfied the biological criteria for a "nuisance dust." The lung reaction was characterized by dust-laden macrophage (dust cell) infiltration in the alveolar ducts and adjoining alveoli with @entity12 of @entity14 . @entity4 at 50 and 250 mg/m3 exposure concentrations revealed a dose-dependent dust cell accumulation, a foamy macrophage response, @entity12 , @entity18 , alveolar bronchiolarization, @entity7 @entity10 , focal @entity17 , and dust deposition in the tracheobronchial lymph nodes. Minute collagenized @entity6 occurred in the alveolar walls enclosing large dust cell aggregates. The @entity8 with massive dust accumulation appeared to be the result of an overwhelmed lung clearance mechanism at 250 mg/m3 exposure. @entity9 and @entity11 occurred at 250 mg/m3 exposure, while no compound-related @entity1 were found in @entity4 exposed to either 10 or 50 mg/m3. In addition to excessive dust loading in the lungs of @entity4 exposed chronically at 250 mg/m3, the @entity1 were different from common @entity0 @entity1 in terms of @entity3 type, anatomic location, tumorigenesis, and were devoid of @entity3 @entity2 . Therefore, the biological relevance of these @entity1 and other @entity8 for @entity0 is negligible.

title: Pulmonary response of @entity4 exposed to titanium dioxide ( XXXX ) by inhalation for two years.

answer: @entity16


abstract: BACKGROUND: Vaccination coverage for @entity1 in the elderly remains low when the physician is the only @entity0 responsible for immunization. Integration of other health care workers may improve the coverage rate of at-risk groups. OBJECTIVES: To estimate vaccination coverage rate by using a strategy based on the systematic intervention of a health care professional proposing vaccination before the doctor's consultation, to evaluate the changes in coverage rates before and after introduction of this strategy, and to assess the feasibility of this intervention and the achieved coverage rate in family physician offices. STUDY DESIGN: Prospective study in a medical outpatient clinic and 5 family physician practices in Switzerland. POPULATION: @entity0 consisted of all @entity0 65 years or older attending a medical outpatient clinic during the vaccination period in 1999 (n = 401), @entity0 65 years or older regularly followed at a medical outpatient clinic in 1998 and 1999 (n = 195), and @entity0 65 years or older presenting to 5 family physician offices in 1999 (n = 598). OUTCOME MEASURED: Rates of vaccination coverage. RESULTS: Among all @entity0 , vaccination coverage rates in 1999 were 85% at the medical outpatient clinic and 83% in family physician offices. Among @entity0 regularly followed at the medical outpatient clinic, vaccination coverage increased from 48% in 1998 to 76% in 1999. Rates of refusal were 9% at the medical outpatient clinic and 14% in the family physician offices. CONCLUSIONS: The systematic intervention of a health care professional to suggest vaccination before the doctor's visit is an effective measure to achieve high coverage rate. Such a strategy also improves outpatient clinic or private practice efficiency by reducing pressures on physicians.

title: Improving XXXX vaccination rates in the elderly.

answer: @entity1


abstract: BACKGROUND: Psychosocial factors have been implicated in the onset and exacerbation of @entity4 . OBJECTIVE: We conducted a randomized, placebo-controlled, double-blind study to investigate the effect of an antidepressant agent, @entity5 , on the course of @entity4 . METHODS: Sixty subjects were enrolled in the study. @entity0 were randomly assigned to treatment groups. @entity0 received @entity5 450 mg/day or placebo and a topical corticosteroid ointment ( @entity6 ) for 6 weeks. @entity0 were examined at the beginning of the study and at 2-week intervals. At each visit, the severity of @entity4 and psychologic status were evaluated with the Psoriasis Area Severity Index (PASI), Beck @entity3 Inventory (BDI), Hamilton Rating Scale for @entity2 (HAM-A), Hamilton Rating Scale for @entity3 (HRS-D-17) and State-Trait @entity2 Inventory including state (STAI-1) and trait @entity2 (STAI-2). RESULTS: Treatment efficacy was able to be evaluated in 22 @entity0 in the @entity5 -treated group and in 20 in the placebo-treated group. The improvement rates in PASI, BDI, STAI-1, and HAM-A scores were significantly higher in the @entity5 treatment group. The level of state @entity2 was diminished in the @entity5 group. Correlation was positive between improvement rates of the @entity1 and state @entity2 in all @entity0 . CONCLUSION: Our results suggest that an antidepressant drug is useful in the treatment of @entity4 .

title: Is the efficacy of topical corticosteroid therapy for XXXX enhanced by concurrent @entity5 therapy? A double-blind, placebo-controlled study.

answer: @entity4


abstract: BACKGROUND AND AIM OF THE STUDY: The optimal management of moderate (grade 2-3+) @entity2 ( @entity2 ) at the time of coronary artery bypass grafting (CABG) remains the subject of controversy. The study aim was to determine whether mitral repair associated with CABG is preferable to CABG alone in @entity0 with moderate @entity1 @entity2 , in terms of intermediate outcome. METHODS: Among 60 @entity0 with moderate @entity1 @entity2 , 30 who underwent CABG plus mitral repair were compared with 30 others who underwent CABG alone. All @entity0 underwent follow up echocardiographic and clinical examinations between 12 and 36 months after surgery. The decision to repair the valve during surgery was totally at the surgeons' discretion. RESULTS: Preoperatively, both groups were substantially homogeneous. @entity0 who had CABG plus mitral repair had a lower NYHA functional class at intermediate follow up, and fewer signs and symptoms of @entity3 . On multivariate analysis, mitral repair proved to be a protective factor for the development of @entity3 . The preoperative size of the mitral annulus was seen to be a risk factor for subsequent @entity3 events. At intermediate follow up, echocardiographic parameters were significantly better in the mitral repair group (left ventricular volume smaller, ejection fraction and pulmonary artery pressure improved). CONCLUSION: The results of this case-control study showed that, in a homogeneous series of @entity0 with moderate @entity1 @entity2 , repair of the mitral valve at the time of CABG leads to a better clinical status due to an improved hemodynamic profile.

title: Moderate XXXX and coronary artery bypass surgery: effect of mitral repair on clinical outcome.

answer: @entity2


abstract: PRIMARY OBJECTIVE: Although family involvement is frequently identified as a key element of successful rehabilitation, questions remain about 'how' clinicians can best involve them. This study explored how clinicians talk about the involvement of families in goal-planning during rehabilitation of adults with acquired @entity1 . RESEARCH DESIGN: Qualitative study drawing on grounded theory to elicit practitioner perspectives. METHODS AND PROCEDURES: Nine clinicians from a range of professional backgrounds were interviewed. Interview data were transcribed and analysed using the constant comparative method of grounded theory. NVivo software was used to assist with data management. MAIN OUTCOMES AND RESULTS: While family were often considered valuable contributors to the @entity2 , they were also seen as potential barriers to the negotiation of goals between clinicians and @entity0 and to @entity0 -clinician relationships. Clinicians described restricting involvement of family members in situations where such involvement was thought not to be in the best interests of the @entity0 . CONCLUSIONS: Goal-planning appeared @entity0 -centred rather than family-centred. Further, clinicians identified concerns about extending family involvement in goal-planning. If clinicians intend to address the needs of family members as well as @entity0 , current approaches to goal-planning (and rehabilitation funding) may need to be reconsidered.

title: Goal planning for adults with acquired XXXX : how clinicians talk about involving family.

answer: @entity1


abstract: BACKGROUND: Despite advances in therapeutic strategies and improved guidelines, morbidity and mortality rates for out-of-hospital @entity3 (OHCA) remain high. Especially, neurological prognosis is one of the most important problems even though brain protection therapy for @entity0 with OHCA has improved greatly in recent years due to the development of emergency post- @entity3 interventions such as mild @entity4 , early percutaneous coronary intervention, and extracorporeal cardiopulmonary resuscitation (CPR). Recently, cerebral regional @entity1 saturation (rSO2) has received attention as a method for evaluation of cerebral oxygenation. We have reported that conventional chest compression did not improve the rSO2 of @entity3 @entity0 if they did not achieve return of spontaneous circulation. It is, however, unclear whether a mechanical CPR device is helpful in improving rSO2. The purpose of this study was to evaluate the effects of load-distributing-band CPR (LDB-CPR) on rSO2. METHODS: In this prospective study, LDB-CPR was begun for OHCA with the AutoPulse(TM) device on @entity0 arrival at hospital. During mechanical CPR, rSO2 values were recorded continuously from the forehead of the @entity0 . CPR for @entity0 with OHCA was performed according to the Japan Resuscitation Council Guidelines 2010 except for using the AutoPulse(TM) instead of manual chest compression. RESULTS: From December 2012 to December 2013, 34 @entity0 (mean age, 75.6        12.8  years) with OHCA were included in this study. Duration of time from recognition of @entity2 to arrival to hospital was 31.0        11.4  min. Compared with the rSO2 value of 38.9        0.7  % prior to starting LDB-CPR, rSO2 values at 4, 8 and 12  minutes increased significantly after initiation of LDB-CPR (44.0        0.9  %, 45.2        0.8  %, and 45.5        0.8  %, respectively, p   <   0.05). CONCLUSION: LDB-CPR significantly increased the rSO2 of @entity3 @entity0 during resuscitation.

title: Load-distributing-band cardiopulmonary resuscitation for out-of-hospital XXXX increases regional cerebral oxygenation: a single-center prospective pilot study.

answer: @entity3


abstract: PURPOSE: To study quality of life (QoL) in responders and nonresponders after radiation therapy for painful bone @entity3 ; and to identify factors predictive for a @entity5 response. @entity1 AND METHODS: The prospectively collected data of 956 @entity1 with @entity0 within the Dutch Bone @entity3 Study were used. These @entity1 , irradiated for painful bone @entity3 , rated @entity5 , QoL, and overall health at baseline and weekly afterward for 12 weeks. Using generalized estimating equations analysis, the course of QoL was studied, adjusted for @entity4 . To identify predictive variables, proportional hazard analyses were performed, taking into account death as a competing risk, and C-statistics were calculated for discriminative value. RESULTS: In total, 722 @entity1 (76%) responded to radiation therapy. During follow-up, responders had a better QoL in all domains compared with nonresponders. @entity1 with @entity0 had a better QoL than @entity1 with @entity2 . In multivariate analysis, baseline predictors for a @entity5 response were @entity0 as @entity4 , younger age, good performance status, absence of visceral @entity3 , and using opioids. The discriminative ability of the model was low (C-statistic: 0.56). CONCLUSIONS: Responding @entity1 show a better QoL after radiation therapy for painful bone @entity3 than nonresponders. Our model did not have enough discriminative power to predict which @entity1 are likely to respond to radiation therapy. Therefore, radiation therapy should be offered to all @entity1 with painful bone @entity3 , aiming to decrease @entity5 and improve QoL.

title: Quality of Life in Relation to @entity5 Response to Radiation Therapy for Painful Bone XXXX .

answer: @entity3


abstract: UNASSIGNED: Studies of @entity3 -specific immune responses in @entity0 have largely assessed systemic responses involving serum Ab and peripheral blood T cell responses. However, recent evidence indicates that tissue-resident memory T (TRM) cells play an important role in local @entity1 intrapulmonary immunity. @entity4 were pulmonary exposed to 2009 pandemic H1N1 virus at days 0 and 28 and immune responses in different tissue compartments were measured. All animals were asymptomatic postinfection. Although only minimal memory immune responses were detected in peripheral blood, a high frequency of @entity3 nucleoprotein-specific memory T cells was detected in the lung at the "contraction phase," 49-58 d after second virus inoculation. A substantial proportion of lung nucleoprotein-specific memory CD8(+) T cells expressed CD103 and @entity6 , phenotypic markers of TRM cells. Lung CD103(+) and CD103(-) memory CD8(+) T cells expressed similar levels of IFN-y and @entity5 . Unlike memory T cells, spontaneous Ab secreting cells and memory B cells specific to @entity3 hemagglutinin were primarily observed in the mediastinal lymph nodes. Little difference in systemic and local immune responses against @entity3 was observed between young adult (6-8 y) and old animals (18-28 y). Using a nonhuman primate model, we revealed substantial induction of local T and B cell responses following 2009 pandemic @entity2 . Our study identified a subset of @entity3 -specific lung memory T cells characterized as TRM cells in @entity4 . The @entity4 model may be useful to explore the role of TRM cells in local tissue protective immunity after rechallenge and vaccination.

title: Tissue Distribution of Memory T and B Cells in @entity4 following Influenza XXXX .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: We sought to identify variables associated with @entity6 in @entity0 with acute @entity4 who receive @entity8 ). METHODS: We performed subgroup analyses of data from a randomized, double-blind, placebo-controlled trial of intravenous @entity8 administered to @entity3 @entity0 within 3 hours of onset. Using multivariable regression modeling procedures, we assessed the relationship of baseline and after-treatment variables with symptomatic and asymptomatic @entity6 during the first 36 hours after treatment. RESULTS: Overall, @entity8 -treated @entity0 had an increase in the absolute risk of symptomatic @entity6 of 6% and a decrease in the absolute risk of 3-month mortality of 4% compared with placebo-treated @entity0 . The only variables independently associated with an increased risk of symptomatic @entity6 in the final multivariable logistic regression model for the 312 @entity8 -treated @entity0 were the severity of @entity2 as measured by the National Institutes of Health @entity3 Scale score (five categories; odds ratio [OR], 1.8; 95% confidence interval [CI], 1.2 to 2.9) and @entity7 (defined as acute @entity9 ) or mass effect by CT before treatment (OR, 7.8; 95% CI, 2.2 to 27.1). This final model correctly predicted those @entity8 -treated @entity0 who would or would not have a symptomatic @entity5 with only 57% efficiency. In the subgroup of @entity0 with a severe @entity2 , @entity8 -treated @entity0 were more likely than placebo-treated @entity0 to have a favorable 3-month outcome (adjusted OR based on multiple outcomes, 4.3; 95% CI, 1.6 to 11.9). These results were similar for the subgroup with @entity1 or mass effect by CT (adjusted OR, 3.4; 95% CI, 0.6 to 20.7). The likelihood of severe disability or death was similar for @entity8 - and placebo-treated @entity0 with these two baseline characteristics. CONCLUSIONS: Despite a higher rate of @entity6 , @entity0 with severe @entity3 or @entity1 or mass effect on the baseline-CT are reasonable candidates for @entity8 , if it is administered within 3 hours of onset.

title: @entity6 after intravenous @entity8 therapy for XXXX . The NINDS @entity8 @entity3 Study Group.

answer: @entity4


abstract: OBJECTIVES: To identify the causes of @entity2 besides vascular events secondary to testicular torsion. METHODS: A total of 102 @entity0 with @entity2 were treated in our hospital from 1984 to 2011. Of these cases, 91 testicular nubbins were excised. Immunohistochemical analysis of testicular nubbins was carried out using anti- @entity3 1 antibody, which is a stable marker of Sertoli cells. Reverse transcription polymerase chain reaction was also carried out using @entity3 1-specific primers. RESULTS: Most testicular nubbins were associated with inguinal lesion (51 @entity0 , 56.0%). Light microscopy showed that 11 @entity0 (12.5%) had seminiferous tubules (with germ cells in three @entity0 [3.4%]), and 77 @entity0 lacked seminiferous tubules, some of which had @entity1 (26 @entity0 , 29.5%), and/or deposition of hemosiderin (21 @entity0 , 23.9%). Immunohistochemical analysis showed @entity3 1 expression not only in the Sertoli cells of the seminiferous tubules in the seminiferous tubule-positive @entity0 , but also in the interstitium of testicular nubbins in the seminiferous tubule-negative @entity0 . Reverse transcription polymerase chain reaction showed @entity3 1 messenger ribonucleic acid expression in the testicular nubbins of both seminiferous tubule-positive and tubule-negative @entity0 . CONCLUSIONS: The presence of @entity3 1-positive cells in the interstitium of @entity2 lacking seminiferous tubules suggests that the disturbance of testicular development after Sertoli cell differentiation and during testicular tubule formation might be involved in the etiology of @entity2 .

title: Feasible etiology of XXXX regarding disturbance of testicular development: histopathological and immunohistochemical evaluation of testicular nubbins.

answer: @entity2


abstract: Step counting is an important index of motion One of the most diffused wearable systems, designed for this purpose, is the pedometer. The accuracy of commercial pedometers has been tested in literature. Several limits have been found in many commercial systems both in healthy subjects and in disable @entity0 . Furthermore, commercial pedometers lack in interoperability. A new wearable system for the step counting has been introduced in this paper. The wearable system is based on a wearable device with a force sensing resistor and a band; it is affixed at the @entity2 gastrocnemius level for the monitoring of the muscular expansion correlated to the gait. The proposed gastrocnemius expansion measurement unit (GEMU) was tested on a three subjects with the @entity1 at the Level 2 of the Tinetti test of unbalance who performed five repetition of 200 steps with three different instructions (fast, slow). The mean error was lower than 0.5%. Results also showed that GEMU performed better than an accelerometer unit (considered in literature the best solution for this disability). The study showed that GEMU had a high performance in a subject with a pathology (the @entity1 ) causing a high degree of unbalance confounding the motion style and thus pedometers. The next phase will be the optimization of GEMU for long term medical applications at @entity0 ' home with the special care to the material and with a comparison to a golden standard.

title: Design and construction of step counters for disable XXXX : preliminary experience at the Italian Institute of Health.

answer: @entity0


abstract: BACKGROUND: Abnormal microcirculation has been suggested in hearts with pathological conditions, particularly in @entity4 hearts, even in the presence of normal epicardial coronary arteries. However, the morphology of coronary capillaries has not been well investigated in those hearts. METHODS: Ultrastructural morphometry of the capillaries in 47 endomyocardial biopsy specimens taken from 30 @entity0 was performed. @entity0 : Six @entity0 had @entity3 with @entity1 -like features ( @entity5 -like HCM), six had HCM, six had @entity5 , five had postmyocarditis, and seven were normal subjects. RESULTS: The short axial diameters of capillaries were similar among the groups. Abnormal stenosis of more than 90% luminal narrowing was found in 31% of capillaries of the @entity5 -like HCM group, 16% of the HCM group, 13% of the @entity5 group, 11% of the postmyocarditis group, and 2% of the normal subjects. Mean (SD) stenosis of the lumen was most severe in @entity5 -like HCM (78(8)%), and more severe in HCM (67(9)%), @entity5 (66(8)%), and postmyocarditis (68(4)%) than normal subjects (56(8)%). The mean cross sectional areas of capillaries were similar among the groups; however, the endothelial cellular area was significantly (p < 0.05) greater in @entity5 -like HCM (24.2 (8.2) microns2) than in normal subjects (14.7 (1.8) microns2), indicating that capillary narrowing was due to the increased volume of capillary endothelial cells. The endothelial cells of the stenosed capillaries showed severely oedematous changes of the cytoplasm wholely or partially, but the cytoplasmic organelles and nuclei appeared intact. CONCLUSION: Narrowing of the coronary capillaries may be of pathophysiological significance in @entity2 in @entity4 hearts, particularly in @entity0 with @entity5 -like HCM.

title: Luminal narrowing of coronary capillaries in @entity0 XXXX hearts: an ultrastructural morphometrical study using endomyocardial biopsy specimens.

answer: @entity4


abstract: BACKGROUND: African trypanosomes constrain livestock and @entity0 health in Sub-Saharan Africa, and aggravate poverty and hunger of these otherwise largely livestock-keeping communities. To solve this, there is need to develop and use effective and cheap tsetse control methods. To this end, we aimed at determining the smallest proportion of a @entity1 herd that needs to be sprayed on the legs, bellies and ears (RAP) for effective @entity0 and Animal @entity3 (HAT/AAT) control. METHODOLOGY/PRINCIPAL FINDING: @entity1 in 20 villages were ear-tagged and injected with two doses of @entity4 (DA) forty days apart, and randomly allocated to one of five treatment regimens namely; no treatment, 25%, 50%, 75% monthly RAP and every 3 month Albendazole drench. @entity1 trypanosome re-infection rate was determined by molecular techniques. ArcMap V10.3 was used to map apparent tsetse density ( @entity2 ) from trap catches. The effect of graded RAP on incidence risk ratios and trypanosome prevalence was determined using Poisson and logistic random effect models in R and STATA V12.1 respectively. Incidence was estimated at 9.8/100 years in RAP regimens, significantly lower compared to 25.7/100 years in the non-RAP regimens (incidence rate ratio: 0.37; 95% CI: 0.22-0.65; P<0.001). Likewise, trypanosome prevalence after one year of follow up was significantly lower in RAP animals than in non-RAP animals (4% vs 15%, OR: 0.20, 95% CI: 0.08-0.44; P<0.001). Contrary to our expectation, level of protection did not increase with increasing proportion of animals treated. CONCLUSIONS/SIGNIFICANCE: Reduction in RAP coverage did not significantly affect efficacy of treatment. This is envisaged to improve RAP adaptability to low income livestock keepers but needs further evaluation in different tsetse challenge, HAT/AAT transmission rates and management systems before adopting it for routine tsetse control programs.

title: Improvements on restricted insecticide application protocol for control of XXXX and animal @entity3 in eastern Uganda.

answer: @entity0


abstract: INTRODUCTION: @entity6 , also known as @entity6 , is a disease of unknown etiology, characterized by an increase in the bone mass in different parts of the body, which results in @entity2 . METHODS: We report the case of a male 40-year-old @entity0 with a diagnosis of @entity6 in 2006 based on imaging studies. The clinical picture began with @entity1 of progressive intensity irradiating to the right pelvic limb and associated with morning @entity5 . Lumbar spine surgery was performed in June 2005 (laminotomy and L4-L5 diskectomy, interbody spaces filled with bone, and a dynamic interspinous spacer in L4-L5), but there was little postoperative improvement. We instituted antiinflammatory medical treatment as described in the literature and the @entity0 did fine. DISCUSSION: This condition is reported as an infrequent entity leading to physicians not considering it within their initial differential diagnoses. It presents with @entity4 as the main symptom, together with neck or @entity1 due to ligament @entity3 and ossification, and increased bone mass leading to the formation of bone bridges. Lumbar or cervical @entity1 is a frequent cause for visiting the neurosurgeon. CONCLUSIONS: The purpose of this paper is to present an unusual case of @entity1 , which increases the diagnostic sensitivity of this disease, and may contribute to avoid unnecessary surgery. This was complemented with literature review.

title: [ XXXX : case report and literature review].

answer: @entity6


abstract: Wet nappies at night could cause @entity0 at risk to die. Tyler first suspected this ten years ago when his head was jerked back from his @entity0 son's cot by the pungent odour of @entity6 gas. This theory is consistent with the full epidemiology of @entity8 . @entity6 is an insidious poison which has a wide and varied range of effects on the respiratory and nervous systems according to concentration and length of exposure. At its mildest it irritates the tissues. In larger doses @entity6 can cause @entity1 and @entity2 . It can also cause @entity4 of affected organs. Its chief danger lies in its potential to disrupt oxygenation at every level throughout the body. Acute and chronic @entity7 profiles indicate the possibility that numbers of @entity0 reported as dying from gastro-intestinal or @entity5 could have been @entity6 @entity7 victims. Predisposing factors, such as smoking during pregnancy, are shown to contribute to the vulnerability of the @entity0 to @entity6 @entity7 . The theory provides the framework for the development of an effective programme of @entity0 @entity3 prevention.

title: @entity8 : the XXXX factor.

answer: @entity6