abstract: BACKGROUND: Two siblings with @entity3 and @entity2 were diagnosed with @entity7 based on low enzyme activity in muscle and high @entity1 / @entity4 ratio in fibroblasts. METHODS: Whole exome sequencing results of fibroblast gDNA from one sibling was narrowed down to 190 SNPs or In/Dels in 185 candidate genes by selecting non-synonymous coding sequence base pair changes that were not present in the SNP database. RESULTS: Two compound heterozygous mutations were identified in both siblings in @entity8 , encoding the 24  kDa subunit of Complex I. The intronic mutation ( @entity9 ) is disease causing and has been reported before. The other mutation is novel ( @entity10 , @entity11 ) and predicted to cause a pathogenic frameshift in the protein. Subsequent investigation of 10 probands with @entity7 from different families revealed homozygosity for the intronic @entity9 mutation in a second, consanguineous family. In this family three of five siblings were affected. Interestingly, they presented with @entity6 but no cardiac involvement. The same genotype had been reported previously in a two families but presenting with @entity3 , @entity5 and @entity0 . CONCLUSION: We have identified @entity8 mutations in two families with @entity7 , including a novel mutation. The diagnosis of @entity6 expands the clinical phenotypes associated with the @entity9 mutation in this gene.

title: Exome sequencing identifies complex I XXXX mutations as a novel cause of @entity6 .

answer: @entity8


abstract: Our purpose was to investigate the factors after predictive outcome 3 months after the injury in terms of mortality and effective independent walking of nonagenarians with hip @entity3 . A prospective study was carried out for 2 yr in the orthopaedic wards on @entity0 referred to geriatricians. The data were subjected to logistic regression forward stepwise analysis. Eighty-nine @entity0 were included in the study; 55 (61.8%) had a trochanteric @entity3 and 86 required a surgical procedure. Before the @entity3 , 83 @entity0 (93.3%) were able to walk by themselves or with minimal supervision. Forty-three @entity0 (48.3%) had an American Society of Anaesthesiologists' of III-IV score. The mean number of @entity5 was four. Mean hospital stay was 18.2 days. Within 3 months, 19 @entity0 (21.3%) had died and 58 (69%) were living in their previous residence. Thirty-three (50% of living @entity0 ) were able to walk by themselves or with minimal help within 3 months of the @entity3 . Predictive variables for 3-month mortality were pre- @entity3 dependence on others for personal toilet and the presence of @entity1 . Predictive variables for independent efficient walking were bowel control and absence of @entity1 before the @entity3 , as well as no development of bed sores during hospitalization.These nonagenarian @entity0 with @entity2 show @entity4 , frequently return to their previous accommodation and present a limited recovery of walking ability.

title: Further experience of nonagenarians with XXXX .

answer: @entity2


abstract: UNASSIGNED: 272 Background: @entity0 with newly diagnosed @entity3 require diagnostic studies and evaluations by physicians that may delay @entity1 care. Uninsured populations are particularly vulnerable. A Nurse Navigator (NN) can help decrease barriers and improve timeliness of care. This study aims to compare timeliness of @entity1 care received by @entity0 referred to a GI MDC Program by the @entity0 's insurance status at the time of referral. METHODS: @entity0 referred to the GI MDC are assigned a NN who evaluates medical history, diagnostic studies, and coordinates further testing and physician evaluations. Timeliness measures assessing milestones in @entity1 care initiation are collected prospectively. Descriptive statistics are presented and average times for measures are compared by insurance status (insured vs. uninsured) using t-tests, chi-square tests, and the @entity4 's Exact test. RESULTS: 366 @entity0 were evaluated between January 2010 and June 2012. 70% (255/366) were for new @entity1 diagnoses. Median age of @entity1 @entity0 was 64 years (range 29-94), 63.1% of @entity0 were male, and 94.1% of @entity0 had insurance. @entity1 diagnosis types were colon/rectal (19.2%), esophageal/gastric (25.1%), hepatobiliary (12.8%) and pancreatic/ampullary/duodenal (35.7%) and 1.6% other. The table describes timeliness and care coordination measures by insurance status. CONCLUSIONS: Uninsured @entity1 @entity0 in our health system appear to receive care in a timely fashion which does not differ from @entity0 with insurance. The impact of a dedicated @entity2 in avoiding disparate care for uninsured warrants further study. [Table: see text].

title: Coordination and timeliness of care by insurance status in a XXXX (MDC) program.

answer: @entity2


abstract: BACKGROUND: With @entity1 of the talar shoulder, their size, the articular cartilage geometry, and the loss of the medial or lateral articular buttress often preclude treatment with traditional osteochondral autograft techniques. We hypothesized that fresh, large osteochondral allograft transplantation is a viable treatment option for @entity0 with such lesions. METHODS: A retrospective review was conducted of @entity0 who underwent fresh talar shoulder allograft transplantation between 2000 and 2007. All @entity0 failed initial conservative management. Preoperatively, a visual analog @entity2 scale of 0 to 10 (with 0 denoting no @entity2 and 10 denoting the @entity2 imaginable) and the Lower Extremity Functional Scale were administered. At the time of most recent follow-up, the visual analog @entity2 scale, the Lower Extremity Functional Scale, the American Orthopaedic Foot _ Ankle Society ankle-hindfoot scale, and the Short Musculoskeletal Function Assessment questionnaire were administered. Radiographs were assessed for allograft incorporation and joint deterioration. RESULTS: Eight @entity0 with a mean age of thirty-one years and a mean follow-up of forty-eight months were included. There was a significant decrease (p < 0.05) in @entity2 , from a mean of 6 points (range, 5 to 8 points) preoperatively to a mean of 1 point (range, 0 to 2 points) postoperatively. The mean Lower Extremity Functional Scale score improved from 37 points initially (range, 24 to 52 points) to 65 points (range, 31 to 75 points; p < 0.05) at the time of final follow-up. The mean postoperative American Orthopaedic Foot _ Ankle Society ankle-hindfoot score was 84 points. The mean Short Musculoskeletal Function Assessment dysfunction index score was 13.3 points and the mean bother index score was 14.3 points. Radiographic lucencies at the graft-host interface were seen in five @entity0 . Four @entity0 required an additional surgical procedure. No @entity0 needed to undergo subsequent arthrodesis or arthroplasty. CONCLUSIONS: These midterm results in a small group of @entity0 indicate that structural fresh allograft transplantation can be a successful surgical option in the treatment of large @entity3 of the talar shoulder [corrected].

title: Midterm results of XXXX of the talar shoulder treated with fresh osteochondral allograft transplantation.

answer: @entity1


abstract: OBJECTIVES: To evaluate the feasibility and efficacy of @entity6 ( @entity6 ) for extra-hepatic portal @entity4 (EHPVO) with recurrent @entity5 (RVB) in @entity0 . METHODS: From November 2005 to December 2013, 28 consecutive paediatric @entity0 with EHPVO treated with @entity6 for RVB refractory to medical/endoscopic therapy and/or surgical treatment in a tertiary-care centre were followed until last clinical evaluation or @entity2 . The median follow-up time was 36.0 months (range 4.0-106.0 months). RESULTS: Seventeen @entity0 and eleven @entity0 aged 7.1 to 17.9 years (median 12.3 years) weighing 19.0-62.0kg (median 33.5kg) were treated. @entity6 was successfully placed in 17 of 28 (60.7%) of @entity0 via a transjugular approach alone (n=4), a combined transjugular/transhepatic approach (n=9), or a combined transjugular/transsplenic approach (n=4). @entity3 occurred in 6 of 17 (35.3%) @entity0 . The cumulative 1- and 3-year free-from-variceal-rebleeding rates in @entity6 success group were higher than those in @entity6 failure group (75.0% and 67.5% versus 45.5% and 18.2%, respectively, p=0.0075). Compared with the @entity6 failure group, the improvements in the height-for-age z-scores were greater in the @entity6 success group (p=0.017). Procedure-related complication occurred in one @entity0 (3.6%), and no episode of post- @entity6 hepatic @entity1 occurred in any @entity0 . Except one @entity0 in the @entity6 success group died at 115 post-operative days, all @entity0 were alive. CONCLUSIONS: @entity6 is feasible and effective in @entity0 with EHPVO and RVB. @entity6 could represent a less invasive alternative to traditional surgical portosystemic shunting or a valuable treatment option if surgery and endoscopic treatment failed.

title: Transjugular Intrahepatic Portosystemic Shunt for Extra-Hepatic Portal @entity4 in XXXX .

answer: @entity0


abstract: A rotating fibrous-bed bioreactor (RFB) was developed for fermentation to produce @entity6 from @entity1 and cornstarch by @entity5 . Fungal mycelia were immobilized on @entity4 cloth in the RFB for a prolonged period to study the fermentation kinetics and process stability. The pH and dissolved @entity0 concentration (DO) were found to have significant effects on @entity2 productivity and yield, with pH 6 and 90% DO being the optimal conditions. A high @entity2 yield of 90% (w/w) and productivity of 2.5 g/L.h (467 g/h.m(2)) was obtained from @entity1 in fed-batch fermentation. When cornstarch was used as the substrate, the @entity2 yield was close to 100% (w/w) and the productivity was 1.65 g/L.h (300 g/h.m(2)). The highest concentration of @entity2 achieved in these fed-batch fermentations was 127 g/L. The immobilized-cells fermentation in the RFB gave a virtually cell-free fermentation broth and provided many advantages over conventional fermentation processes, especially those with freely suspended fungal cells. Without immobilization with the @entity4 cloth, mycelia grew everywhere in the fermentor and caused serious problems in reactor control and operation and consequently the fermentation was poor in @entity2 production. @entity0 transfer in the RFB was also studied and the volumetric @entity0 transfer coefficients under various aeration and @entity3 conditions were determined and then used to estimate the @entity0 transfer rate and uptake rate during the fermentation. The results showed that the @entity0 uptake rate increased with increasing DO, indicating that @entity0 transfer was limited by the diffusion inside the mycelial layer.

title: Production of @entity6 from XXXX and starch by immobilized cells of @entity5 in a rotating fibrous bed bioreactor.

answer: @entity1


abstract: OBJECTIVE: To investigate the significance of nuclid myocardial scintigraphy (ECT) as a clinical method for guiding the diagnosis, therapy and prognosis of a cute @entity2 . METHODS: 48 @entity0 with acute @entity2 were divided into two groups, 21 @entity0 with ECT showing diffuse myocardial perfusion defect constituted a positive group and the remaining 27 with normal ECT a negative group. The relationship between the clinical data and treatment effect in the two groups were analyzed. RESULTS: In the positive group, CK-MB in 57.14% of the @entity0 was higher than normal and 71.43% of the @entity0 had ventricular @entity4 (VPB) and @entity3 ( @entity3 ). The average number of VPB per 24 hour was (4228 +/- 1506) beats. In the negative group, the values of the above items were 33.33%, 44.44% and (2268 +/- 924) beats. The difference between the two groups was statistically significant (all of P < 0.01). After treatment of acute @entity2 , ECT of all the @entity0 in the positive group returned to normal completely 85.71% of the @entity0 with @entity4 recovered from the @entity1 . 38.10% of the @entity0 with @entity4 had @entity1 again during a follow-up of 4 years. However, in the negative group, only 59.26% of the @entity0 with @entity4 recovered from the @entity1 and 66.67% had @entity1 again during the 4 years. The therapeutic effect between the two groups was also statistically different (all of P < 0.01). CONCLUSION: Up to now, there has been no unified diagnostic standard for acute @entity2 , so ECT may be an exact and reliable diagnostic method for acute @entity2 . It may help to avoid error in diagnosis, waste in health resources and side effects of the medications.

title: [The value of nuclide myocardial scintigraphy for the clinical of acute XXXX ].

answer: @entity2


abstract: Hypericum perforatum extracts (HPE) inhibit @entity3 intake in @entity0 . @entity6 and hyperforin have been proposed as major active principles of HPE. The present study compared the effect on @entity3 intake in @entity1 -preferring @entity0 of two Hypericum perforatum extracts: a methanolic extract containing 0.3% hypericin and 3.8% hyperforin (HPE1) and a @entity2 extract ( @entity9 ) with 24.33% hyperforin and very low hypericin content. Freely feeding and drinking @entity0 were offered 10% @entity3 2 h/day and HPE were given intragastrically 1 h before access to @entity3 . Both extracts dose-dependently reduced @entity3 intake, @entity9 being about eight times more potent than HPE1. Food and water intakes were not affected by doses that reduced @entity3 intake. @entity9 , unlike HPE1, reduced blood- @entity1 levels (BAL) at doses of > or = 31.2 mg/kg, whereas the dose of 15.6 mg/kg, which reduced @entity3 intake, did not significantly modify BAL; blood- @entity5 levels were never increased. As previously observed for HPE1, intracerebroventricular pretreatment with @entity4 (150 microg/ @entity0 ) did not affect attenuation of @entity3 intake induced by @entity9 , but reduced its effect in the forced swimming test (FST). Intraperitoneal pretreatment with the @entity8 antagonist @entity7 (0.25 mg/kg) did not affect inhibition of @entity3 intake induced by HPE1 (250 mg/kg) or @entity9 (125 mg/kg), but abolished the effect of both extracts in the FST. In conclusion, the present results indicate that @entity9 inhibits @entity3 intake more potently than HPE1; the higher potency of @entity9 parallels the hyperforin content, suggesting that hyperforin may have an important role in reducing @entity3 intake. Moreover, different neurochemical mechanisms are apparently responsible for the reduction of @entity3 intake and for the antidepressant-like effect of HPE.

title: Effects of a methanolic extract and a hyperforin-enriched XXXX extract of Hypericum perforatum on @entity1 intake in @entity0 .

answer: @entity2


abstract: @entity4 ( @entity4 ) and 2B (CYP2B) mRNA and protein expression was examined in primary cultured @entity0 hepatocytes under basal cell culture conditions and in response to three prototypic @entity4 inducers, i.e. @entity2 , @entity3 , and @entity5 . Xenobiotic treatment for 24 hr, initiated after hepatocytes had been maintained in culture for 72 hr, resulted in 2-8-fold increases in @entity4 protein levels, relative to untreated cells. A >/=2-fold increase in @entity4 protein levels was detected at the lowest concentration (1 mM) of each of the xenobiotics examined. The increase in @entity4 protein expression was not accompanied by any significant increase in 2E1 mRNA expression. In contrast, CYP2B protein and mRNA levels were increased by @entity3 or @entity5 at concentrations greater than 1 mM. @entity2 (up to 100 mM) failed to significantly increase CYP2B protein or mRNA levels. The maximal increases measured for CYP2B protein and mRNA ( approximately 25-fold and approximately 90-fold, respectively) after treatment of hepatocytes with @entity3 were comparable to those measured in our laboratory, and reported by others, for @entity1 treatment of primary cultured @entity0 hepatocytes. The results of this study show that the pattern of expression of @entity4 B in this primary cultured @entity0 hepatocyte system and the magnitude of induction parallel those reported for @entity0 liver in vivo in response to these xenobiotics. This primary hepatocyte culture system provides opportunities for studies of the role of @entity4 in the metabolism and bioactivation of drugs, chemicals, and putative carcinogens, as well as mechanistic studies on xenobiotic-mediated regulation of @entity4 expression.

title: Xenobiotic-enhanced expression of cytochromes P450 2E1 and 2B in primary cultured XXXX hepatocytes.

answer: @entity0


abstract: AIM: The study was aimed to examine the appropriateness of using the Mini Nutritional Assessment to screen for risk of under- and over-nutrition in adults with @entity2 . BACKGROUND: @entity0 with @entity2 are at increased risk of @entity3 , but routine monitoring of their nutritional conditions are not widely done. DESIGN: The study purposively recruited 104 institutionalised adults (>= 19 years old) with @entity2 to serve as @entity0 . METHODS: @entity0 were interviewed with a structured questionnaire to elicit personal data, health-related information and answers to items in the Activities of Daily Living and the Mini Nutritional Assessment scales and measured for anthropometrics. Biochemical data were taken from their routine medical measurements. Each subject was graded with the Mini Nutritional Assessment that adopted Taiwanese-specific anthropometric cut-off points (T1) and an alternative version that omitted the body mass index item (T2). RESULTS: Both Mini Nutritional Assessment versions were able indentifying individuals at risk of @entity3 among adults with @entity2 and rated comparable proportions of @entity0 malnourished (6  7 and 5  8% for Mini Nutritional Assessment-T1 and Mini Nutritional Assessment-T2, respectively) or at risk of @entity3 (14  4 and 17  3%, respectively). @entity0 with @entity1 were at greater risk of malnourishment than @entity0 with other disabilities. CONCLUSION: The Mini Nutritional Assessment is appropriate for screening for under- and over-nutrition in adults with @entity2 . The Mini Nutritional Assessment (especially the version without body mass index) can make routine monitoring of nutritional status of these @entity0 an easier task. However, further studies are needed to develop subtype-specific versions (tools) as various subtypes of @entity2 are associated with different nutritional problems. RELEVANCE TO CLINICAL PRACTICE: The Mini Nutritional Assessment can serve as a tool for routine screening for under- and over-nutrition in @entity0 with @entity2 .

title: The Mini Nutritional Assessment (MNA) is useful for assessing the risk of @entity3 in adults with XXXX .

answer: @entity2


abstract: OBJECTIVE: To assess the significance of magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) abnormalities in @entity0 with @entity4 ( @entity4 ). METHODS: Forty-four @entity0 with @entity4 were retrospectively analysed. @entity0 were classified into three groups [1 and 2: @entity0 with central nervous system (CNS) manifestations before and after starting high-dose @entity1 therapy, respectively; 3: @entity0 without CNS manifestations. MRI was performed in all 44 @entity0 and SPECT in 31. RESULTS: Abnormal findings in MRI were found in 19 @entity0 . MRI abnormalities were significantly more frequent in @entity0 with CNS manifestations than in those without [71 vs 17%, odds ratio (OR) 11.9, confidence interval (CI) 2.8-49.9, P=0.0003]. After the initiation of @entity1 therapy, @entity0 with CNS manifestations also had an increased frequency of abnormal MRI. No correlation was found between SPECT findings and CNS manifestations. However, @entity0 with CNS manifestations after starting @entity2 showed a markedly increased frequency of abnormal MRI and SPECT compared with those without CNS manifestations (80 vs 7%; OR 56, CI 4.4-719, P=0.0003). The positive predictive @entity3 in both techniques in developing CNS manifestations after starting @entity2 was 89%. CONCLUSION: MRI findings correlated with CNS manifestations in @entity4 . Where there is a high suspicion of CNS involvement, the combination of MRI and SPECT may be useful in predicting CNS manifestations after starting @entity1 therapy.

title: Cerebral imaging by magnetic resonance imaging and single photon emission computed tomography in XXXX .

answer: @entity4


abstract: UNASSIGNED: 4695 Background: Options for @entity0 with progression of @entity3 following @entity4 ablation and chemotherapy are limited. Prior studies have demonstrated the efficacy of @entity2 in this group of @entity0 , but safe and effective agents are limited. Given prior data demonstrating the safety and ease of using an @entity1 patch, we tested the hypothesis that the patch would be a safe and effective option for @entity0 with hormone and chemotherapy @entity3 . METHODS: In this ongoing study, ten @entity0 with hormone @entity3 who had progressed after at least one chemotherapy regimen were enrolled. @entity0 were treated with two transdermal patches (total daily dose: 0.2 mg of @entity1 ) changed weekly. RESULTS: 7/10 @entity0 received one prior and 3/10 two or more prior chemotherapy regimens. Median age was 64 years (range 57 to 76). @entity5 ( @entity5 ) decreased in 5/10 @entity0 (mean decrease 27%). 2/3 @entity0 that were treated for at least 3 months had stable disease, as defined as < 25% increase over the first 3 months of therapy. 7/10 @entity0 remain on study. Therapy was well tolerated. There were no grade 2 or 3 adverse events. CONCLUSION: In @entity0 with hormone and chemotherapy @entity3 , transdermal @entity1 patches may offer a safe and active option of therapy, but further study is warranted and ongoing. No significant financial relationships to disclose.

title: A phase II salvage trial of transdermal @entity1 in the treatment of hormone and chemotherapy XXXX : A Cancer Institute of New Jersey Oncology Group Study NJ1803.

answer: @entity3


abstract: UNASSIGNED: The goal of this study was to identify associations between positron emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) in @entity0 presenting with @entity3 (SCC) with @entity1 site, size, histologic differentiation, smoking, and @entity2 . Charts of @entity0 with oropharyngeal and laryngeal SCC who underwent @entity4 PET/CT scans were reviewed between May 2007 and August 2013. Statistical analyses included modeling log-transformed SUVmax values by @entity1 site, size, histologic differentiation, smoking status, and @entity2 using unadjusted linear regressions. Differences were considered statistically significant for P< 0.05. A total of 111 @entity0 (54 with oropharynx and 57 with @entity1 ) were included, 83 @entity0 and 28 @entity0 with an average age of 57.5 years old. There was a significantly higher pack-year smoking history (P = 0.005) in the @entity1 group. While @entity1 T-stage was found to be significantly different (P < 0.0001), there was no difference in @entity1 size between the two groups: 3.16 cm and 3.58 cm in the oropharynx and larynx, respectively (P = 0.55). In the oropharynx cohort, SUVmax was associated with both @entity1 size (P = 0.0001) and stage (P < 0.0002). Interestingly, SUVmax differed by @entity1 differentiation in the larynx (P = 0.04) but not the oropharynx (P = 0.71). Finally, there was no significant difference in SUVmax relative to @entity2 and smoking status. PET/CT SUVmax correlated with both @entity1 size and stage in @entity1 @entity0 , and it correlated only with @entity1 differentiation but not the size or stage in the larynx. There were no significant differences in SUVmax by @entity2 or smoking status.

title: Correlation of Positron Emission Tomography/Computed Tomography Scan with Smoking, Tumor Size, Stage and Differentiation in Head and Neck Cancer XXXX .

answer: @entity0


abstract: @entity3 is the second leading cause of morbidity and mortality in @entity1 survivors. The objective of this international cardiac oncology survey was to gain a better understanding of current knowledge and practice patterns among HCPs involved in the management of @entity1 @entity0 exposed to potentially @entity3 drugs. Between 2012 and 2013, we conducted an email-based survey of HCPs involved in the management of @entity2 in @entity1 @entity0 . 393 survey responses were received, of which 77 were from Canadian respondents. The majority of respondents were cardiologists (47%), followed closely by medical oncologists. The majority of respondents agreed that cardiac issues are important to @entity1 @entity0 (97%). However, only 36% of total respondents agreed with an accepted definition of @entity3 . While 78% of respondents felt that cardiac medications are protective during active @entity1 treatment, only 51% would consider prescribing these medications up-front in @entity1 @entity0 . Although results confirm a high level of concern for cardiac safety, there continues to be a lack of consensus on the definition of @entity3 and a discrepancy in clinical practice between cardiologists and oncologists. These differences in opinion require resolution through more effective research collaboration and formulation of evidence-based guidelines.

title: An International Survey of Health Care Providers Involved in the Management of Cancer @entity0 Exposed to XXXX Therapy.

answer: @entity3


abstract: Microbial tropism, the infection of specific cells and tissues by a microorganism, is a fundamental aspect of host-microbe interactions. The intracellular bacteria Wolbachia have a peculiar tropism for the stem cell niches in the @entity0 ovary, the microenvironments that support the cells producing the eggs. The molecular underpinnings of Wolbachia stem cell niche tropism are unknown. We have previously shown that the patterns of tropism in the ovary show a high degree of conservation across the Wolbachia lineage, with closely related @entity1 usually displaying the same pattern of stem cell niche tropism. It has also been shown that tropism to these structures in the ovary facilitates both vertical and horizontal transmission, providing a strong selective pressure towards evolutionary conservation of tropism. Here we show great disparity in the evolutionary conservation and underlying mechanisms of stem cell niche tropism between male and female gonads. In contrast to females, niche tropism in the male testis is not pervasive, present in only 45% of niches analyzed. The patterns of niche tropism in the testis are not evolutionarily maintained across the Wolbachia lineage, unlike what was shown in the females. Furthermore, hub tropism does not correlate with cytoplasmic incompatibility, a Wolbachia-driven phenotype imprinted during spermatogenesis. Towards identifying the molecular mechanism of hub tropism, we performed hybrid analyses of @entity1 in non-native hosts. These results indicate that both Wolbachia and host derived factors play a role in the targeting of the stem cell niche in the testis. Surprisingly, even closely related @entity1 in @entity0 , derived from a single ancestor only 8,000 years ago, have significantly different tropisms to the hub, highlighting that stem cell niche tropism is rapidly diverging in males. These findings provide a powerful system to investigate the mechanisms and evolution of microbial tissue tropism.

title: Extreme divergence of wolbachia tropism for the stem-cell-niche in the XXXX testis.

answer: @entity0


abstract: @entity5 ( @entity5 ) and @entity4 ( @entity4 ), which are known to be minor constituents of @entity2 , commonly are associated with almost all types of @entity2 . In this study, the distribution of @entity5 -, @entity4 - and ubiquitin (Ub)-immunoreactivity (IR) in @entity2 in the liver and spleen of @entity0 @entity3 (34 autopsy cases: 17 immunoglobulin light chain derived, 17 amyloid A protein derived) and experimental @entity1 @entity6 is examined using an immuno-histochemical technique. In @entity0 cases, all of the @entity2 examined showed colocalization of @entity5 - and @entity4 -IR with individual amyloid proteins. In experimental @entity6 , @entity5 -IR of @entity2 in the liver and spleen and @entity4 -IR in the liver were seen uniformly throughout this experiment. In contrast, @entity4 -IR in the spleen was not uniform at the phase of @entity2 . At 4 weeks and at 16 weeks after casein injection, @entity4 -IR was unevenly distributed in @entity2 in the perifollicular area; however, from 6 to 12 weeks it was seen to be uniform. Ubiquitin-IR of @entity2 in @entity0 cases was seen in 22 of 34 livers and in 22 of 33 spleens. In experimental @entity6 , Ub-IR of @entity2 was demonstrated in the space of Disse in all @entity1 examined, and there appeared to be a gradual increase in intensity with the amount of @entity2 . However, in the spleen, @entity2 did not react with anti-Ub antibody in any phase of amyloid induction. These results suggest that @entity4 and Ub are not always associated with the process of @entity2 and may appear in a deposit after the deposition.

title: An immunohistochemical study of amyloid P component, @entity4 and ubiquitin in @entity0 and XXXX amyloidoses.

answer: @entity1


abstract: SUMMARY: Correlated responses in pituitary gland weight and @entity4 ( @entity4 ) concentration in the serum and pituitary were studied in lines of @entity0 selected for growth rate, and in controls. The selection criteria were @entity1 between 28 and 38 days on an ad libitum feed intake (EPA line), or on intake restricted to 80% of the control @entity0 (EPR line), and @entity1 between 48 and 58 days under the above two feeding regimes ( @entity3 and @entity2 lines). The control line was maintained by random breeding. In generation 13, pituitary weight and @entity4 levels were determined at 38 days in lines EPA, EPR and the control and at 58 days in lines @entity3 , @entity2 and the control. Pituitary weight, corrected for body @entity1 , was smaller in the EPA line than in the control line at 38 days and was greater in the @entity2 line than in the control line at 58 days. There were large differences in serum @entity4 concentrations between the selected lines and the control; the differences were statistically significant at 38 days, with the EPA and EPR lines having lower levels than the controls. ZUSAMMENFASSUNG: Ver  nderung von Wachstumshormonspiegel bei Selektion f  r Zuwachs bei M  usen Ver  nderungen im Hypophysengewicht und Wachstumshormon-( @entity4 )-Konzentrationen im Serum und in der Hypophyse wurden bei Wachstumsselektionslinien und bei Kontrollm  usen untersucht. Selektionskriterien waren Zuwachs zwischen 28 und 38 Tagen bei ad libitum Futteraufnahme (EPA Linie) oder bei Linien, wo Futteraufnahme auf 80% derjenigen der Kontrollm  use (EPR Linie) begrenzt wurde und Zuwachs zwischen 48 und 58 Tagen unter beiden Futterweisen ( @entity3 und @entity2 Linie). Die Kontrollinie wurde durch Zufallspaarung fortgepflanzt. In Generation 13 wurden Hypophysengewicht und Wachstumshormonspiegel im Alter von 38 Tagen in Linien EPA, EPR und in Kontrollen und bei 58 Tagen in Linien @entity3 und @entity2 und Kontrollen bestimmt. Hypophysengewicht, korrigiert f  r Zuwachs, war geringer in der @entity3 Linie als in der Kontrolle bei 38 Tagen Alter und gr    er in der @entity2 Linie als in der Kontrolle bei 58 Tagen. Zwischen @entity4 Konzentrationen selektierter und Kontrollinien waren erhebliche Differenzen, die bei 38 Tagen signifikant waren, wobei EPA und EPR Linien geringere Werte als die Kontrollen aufwiesen.

title: Correlated responses in XXXX to selection for @entity1 in @entity0 .

answer: @entity4


abstract: BACKGROUND: Management of newborns with interrupted aortic arch (IAA) remains challenging. Associated severe @entity4 ( @entity4 ) have often led to increased mortality with neonatal biventricular repair. We review our experience with an alternative approach for this complex surgical problem. METHODS: From May 1991 to June 1999, 28 neonates were treated for IAA. Thirteen of 28 neonates (46%) had type B IAA, @entity3 ( @entity3 ) and severe @entity4 (Z value -2 to -7; mean -5 +/- 1.7). Mean age was 8 days (3 to 23 days old) with average weight of 3.3 kg (2.4 to 4.2 kg). Eight of 13 (62%) had @entity5 . Ten of 13 (77%) had thymic aplasia and chromosome 22 region qll deletion. All 13 @entity0 were treated initially with a modified Norwood procedure. RESULTS: There were no perioperative @entity1 . Complications included 2 @entity0 with recurrent arch stenosis treated with @entity2 . Two @entity0 had systemic arterial shunt revision. Follow-up ranged from 2 to 99 months old (mean 39 months). There were 2 late @entity1 unrelated to any operation. Nine of 12 @entity0 had a second stage palliation consisting of a bidirectional Glenn shunt. Six @entity0 went on to have biventricular repairs (3 Ross-Konno, 2 Rastelli, 1 @entity3 closure with LVOT resection). One @entity0 had a modified Fontan operation and 5 @entity0 are awaiting potential biventricular repair. CONCLUSIONS: @entity0 with IAA and severe @entity4 may be managed by initial Norwood palliation with an excellent outcome likely. This initial "univentricular" approach has enabled eventual successful biventricular repair despite severe @entity4 .

title: Successful biventricular repair after initial Norwood operation for interrupted aortic arch with severe XXXX .

answer: @entity4


abstract: BACKGROUND: The role of specific IgE (sIgE) against Der @entity2 and Der p 2 in Chinese @entity0 with @entity3 ( @entity3 ) @entity1 has not yet been well investigated. METHODS: One hundred @entity0 were enrolled, based on sensitization and doctor-diagnosed @entity1 to @entity3 . Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity to @entity4 (Dp) extract, Der @entity2 , Der p 2 and Der p 10 was measured by ImmunoCAP. RESULTS: Almost all @entity0 were sensitized to Der @entity2 (95%) and Der p 2 (93%), with both allergens together being largely responsible for the total anti- @entity3 IgE response. No evidence for a significant role of Der p 10 was found. Overall, IgE responses to @entity3 and its 2 major allergens were higher in @entity0 than in adults in this cross-sectional study. With increasing age, IgE responses to Der p 2 become more important. A positive correlation was observed between the reaction of sIgE against Dp, Der @entity5 and the number of organs (including the eyes, nose, lungs and skin) that were affected in @entity0 . CONCLUSIONS: In China, Der @entity2 and Der p 2 are the dominant allergens in @entity0 with @entity3 @entity1 . The relative importance of Der @entity2 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.

title: Evaluation of the Role of IgE Responses to Der @entity2 and Der p 2 in Chinese House Dust Mite-Allergic XXXX .

answer: @entity0


abstract: BACKGROUND: We hypothesized that the postoperative serum level of TA90-IC, an immune complex of a 90-kDa @entity1 -associated antigen and its antibody, might have a significant correlation with recurrence and survival in @entity0 with thick primary @entity2 . METHODS: We used our prospective @entity2 database to identify all @entity0 who underwent wide local excision and sentinel lymphadenectomy for primary @entity2 > or =4 mm and from whom sera had been collected and cryopreserved within 6 months after surgery. These sera were analyzed in a blinded fashion for TA90-IC status by using our double-determinant enzyme-linked immunosorbent assay. Results were correlated with disease-free survival (DFS) and @entity3 ( @entity3 ). Standard prognostic factors for @entity2 were then compared with TA90-IC status for the prediction of DFS and @entity3 . RESULTS: The sensitivity and specificity of the TA90-IC assay for predicting recurrence were 70% and 85%, respectively. Five-year DFS and @entity3 rates were higher for the TA90-IC-negative group than the positive group. The differences in DFS and @entity3 between the TA90-IC-negative and -positive groups were significant. At a median follow-up of 25 months, multivariate analysis identified postoperative TA90-IC status and sex as significant predictors of DFS. TA90-IC status was the only independent prognostic factor with multivariate analysis. CONCLUSIONS: TA90-IC status after resection of thick primary @entity2 accurately predicts outcome. A positive postoperative TA90-IC level might affect a decision regarding adjuvant therapy, regardless of regional nodal status.

title: Serum TA90 immune complex assay can predict outcome after resection of thick (> or =4 mm) primary XXXX and sentinel lymphadenectomy.

answer: @entity2


abstract: OBJECTIVE: To report a case of @entity2 associated with @entity5 , with successful treatment, and to review the literature concerning @entity3 treatment. CASE REPORT: @entity0 with @entity5 and @entity3 diagnosed by ultrasonography during her pregnancy. At that time, the @entity3 on the right side was 9 cm in diameter. Conservative management was selected during her pregnancy. The @entity0 returned 7 years later, with a 24.7 x 19.2 x 10.7 cm @entity1 on the right side and another of 13 x 11.5 x 6.5 cm on the left side, in addition to multiple small @entity3 . A nephron-sparing surgery with tumoral enucleation was performed on the right side, and after 3 months, the @entity1 on the left side was removed. Renal function in the post-operative period was preserved, and contrast medium progression was uniform and adequate in both kidneys. CONCLUSION: We conclude that an @entity3 larger than 4 cm should be removed surgically, since they have a greater growth rate and pose a risk of @entity4 . Resection of smaller @entity1 is safe and has decreased morbidity. Tumoral enucleation is an effective treatment method that preserves kidney function.

title: @entity2 associated with hepatic lipoma in a XXXX with @entity5 .

answer: @entity0


abstract: BACKGROUND: In this observational trial, data were collected on the effectiveness and tolerability/safety of a nasal spray containing @entity2 and essential oils (trade name Rhinospray(  ) Plus) used for symptomatic treatment of @entity1 due to common cold. METHODS: The trial was performed in 300 @entity0 , adolescents and adults, who were to be treated with Rhinospray(  ) Plus for up to 4  times per day for up to 10  days. Primary endpoints were the change from baseline to final visit in the mean of three single symptom scores (blocked nose, sneezing, and runny nose) and the mean improvement in two quality-of-life parameters (ability to perform normal daytime activities and quality of sleep). RESULTS: A total of 108 @entity0 , 30 adolescents and 162 adults were treated with Rhinospray(  ) Plus. No @entity0 discontinued prematurely. There was a mean reduction of 2.0      0.6 (standard deviation) in nasal symptom scores from baseline to final visit; 297 of 300 of @entity0 (99.0  %) reported an improvement. The mean value for improvement in quality-of-life parameters was 1.3      0.5. Improvement in daytime activities was reported by all 300 @entity0 (100.0  %) and in quality of sleep by 292 @entity0 (97.4  %). Effectiveness and tolerability were rated as 'very good' or 'good' by 95.4  % and 97.4  % of @entity0 , respectively; the investigators rated effectiveness and tolerability as 'very good' or 'good' for 97.4  % and 100.0  % of @entity0 , respectively. No adverse events were reported. CONCLUSIONS: Community-based @entity0 reported a relief in @entity1 and improvement in quality of life as a result of treatment with Rhinospray(  ) Plus. Treatment was well-tolerated.

title: Treatment of @entity1 with a nasal spray containing XXXX and essential oils: a multicenter, uncontrolled, observational trial.

answer: @entity2


abstract: BACKGROUND: @entity7 is a rare benign inflammatory @entity8 , presenting as a painful nodular mass within a muscle, and characterized by spontaneous resolution within weeks. PURPOSE: To assess the clinical and imaging findings of focal @entity5 simulating a @entity2 at clinical examination, with no history of @entity3 . MATERIAL AND METHODS: This study describes the locations and appearance at ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) of this condition in a series of five @entity0 . RESULTS: MRI and US displayed a solid intramuscular " @entity2 " and suggested a continuum between the proximal and distal muscle fibers that appeared thickened within the nodular lesion, a sign that has been reported in @entity6 . MRI showed @entity1 in adjacent muscles and soft tissues, as well as intense enhancement of the mass. Intense vascular flows were seen at Doppler analysis. CT did not reveal the appearance of peripheral ossifications, ruling out the diagnosis of @entity6 . In some @entity0 , the diagnosis of @entity4 had been suggested as possible by the radiologist. Imaging follow-up with MRI showed complete resolution of the masses over several weeks, thus avoiding a biopsy; no recurrence was observed at long-term follow-up (more than 24 months). CONCLUSION: This paper highlights MRI and US findings in focal non-ossifying @entity7 , and emphasizes the role of MRI in suggesting this diagnosis, leading to the careful follow-up of the lesion until its resolution, and ruling out more aggressive lesions.

title: Self-resolving focal non-ossifying XXXX : a poorly known clinical and imaging entity diagnosed with MRI.

answer: @entity7


abstract: BACKGROUND: A smoke-free law came into effect in Spain on 1st January 2006, affecting all enclosed workplaces except hospitality venues, whose proprietors can choose among totally a smoke-free policy, a partial restriction with designated smoking areas, or no restriction on smoking on the premises. We aimed to evaluate the impact of the law among hospitality workers by assessing @entity1 ( @entity1 ) exposure and the frequency of respiratory symptoms before and one year after the ban. METHODS AND FINDING: We formed a baseline cohort of 431 hospitality workers in @entity2 . Of them, 318 (66.8%) were successfully followed up 12 months after the ban, and 137 nonsmokers were included in this analysis. We obtained self-reported exposure to @entity1 and the presence of respiratory symptoms, and collected saliva samples for @entity0 measurement. Salivary @entity0 decreased by 55.6% after the ban among nonsmoker workers in venues where smoking was totally prohibited (from median of 1.6 ng/ml before to 0.5 ng/ml, p<0.01). @entity0 concentration decreased by 27.6% (p = 0.068) among workers in venues with designated smoking areas, and by 10.7% (p = 0.475) among workers in venues where smoking was allowed. In Portugal and Andorra, no differences between @entity0 concentration were found before (1.2 ng/ml) and after the ban (1.2 ng/ml). In Spain, reported respiratory symptom declined significantly (by 71.9%; p<0.05) among workers in venues that became smoke-free. After adjustment for potential confounders, salivary @entity0 and respiratory symptoms decreased significantly among workers in Spanish hospitality venues where smoking was totally banned. CONCLUSIONS: Among nonsmoker hospitality workers in bars and restaurants where smoking was allowed, exposure to @entity1 after the ban remained similar to pre-law levels. The partial restrictions on smoking in Spanish hospitality venues do not sufficiently protect hospitality workers against @entity1 or its consequences for respiratory health.

title: Impact of the Spanish smoking law on exposure to XXXX and respiratory health in hospitality workers: a cohort study.

answer: @entity1


abstract: UNASSIGNED: In the infarcted myocardium, necrotic cardiomyocytes activate innate immune pathways, stimulating pro-inflammatory signaling cascades. Although @entity0 plays an important role in clearance of the @entity3 from dead cells and matrix debris, repair of the infarcted heart requires timely activation of signals that negatively regulate the innate immune response, limiting @entity1 . We have previously demonstrated that @entity7 , a member of the @entity6 family that suppresses toll-like receptor/interleukin-1 signaling, is upregulated in the infarcted heart in both macrophages and fibroblasts, and restrains pro-inflammatory activation attenuating adverse remodeling. Although @entity7 is known to suppress inflammatory activation of macrophages, its role in fibroblasts remains unknown. Our current investigation examines the effects of @entity7 on fibroblast phenotype and function. In vitro, @entity7 null cardiac fibroblasts have impaired capacity to contract free-floating collagen pads. @entity7 loss reduces transforming growth factor (TGF)-b-mediated a-smooth muscle actin ( @entity4 ) expression. @entity7 deficient cardiac fibroblasts exhibit a modest reduction in @entity5 -stimulated Smad activation and increased expression of the @entity4 repressor, Y-box binding protein (YB)-1. In a model of non-reperfused @entity2 , @entity7 absence does not affect collagen content and myofibroblast density in the @entity3 , but increases YB-1 levels and is associated with attenuated @entity4 expression in isolated @entity3 . Our findings suggest that, in addition to its role in restraining @entity0 following reperfused @entity3 , @entity7 may also contribute to myofibroblast conversion.

title: The role of Interleukin Receptor Associated Kinase ( XXXX )-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused @entity2 .

answer: @entity6


abstract: The LuxS protein is required for the biosynthesis of the type 2 autoinducer ( @entity3 ), which is involved in quorum sensing in a wide range of bacterial species. We have determined the effects of a defined luxS mutation on the virulence of @entity2 . Although the luxS mutant displayed reduced virulence relative to its wild-type parent, the type 2 strain D39, it was by no means avirulent in a @entity0 model. After intranasal administration, the luxS mutant was able to colonize the nasopharynx of the @entity0 as efficiently as the wild type. However, it was less able to spread from the nasopharynx to the lungs or the blood. Intraperitoneal coadministration studies indicated that the luxS mutant was less fit and was readily outcompeted by wild-type D39. However, when administered on its own by this route, the mutant was able to proliferate and cause fatal @entity1 , albeit at a lower rate than the wild type. Western blot analysis of whole-cell lysates of the mutant and its parent did not reveal any differences in the levels of several well-characterized virulence proteins. However, analysis of Coomassie blue-stained protein profiles after separation by @entity6 - @entity5 gel electrophoresis showed that mutation of luxS had pleiotropic effects on protein expression in all cellular compartments. This is consistent with the product of luxS having a regulatory role in @entity4 . This is the first report of a direct role for luxS (and by inference, @entity3 ) in the virulence of a gram-positive pathogen. However, the fact that mutagenesis of luxS does not completely attenuate @entity4 has implications for the possible use of @entity3 antagonists for treatment of @entity7 .

title: Mutation of luxS of XXXX affects virulence in a @entity0 model.

answer: @entity2


abstract: UNASSIGNED: @entity0 with @entity2 smoke cigarettes at a higher rate than the general population. We hypothesized that a factor in this comorbidity is sensitivity to the reinforcing and reinforcement-enhancement effects of nicotine. Phencyclidine ( @entity3 ) was used to model behavioral changes resembling negative symptoms of @entity2 in @entity1 . Ultrasonic vocalizations (USVs) in @entity1 have been used to measure emotional states, with 50   kHz USVs indicating positive states and 22   kHz USVs indicating negative states. Total and categorized numbers of 22 and 50   kHz USVs and USVs during a visual stimulus (e.g. a potential measure of reinforcement-enhancement) were examined in @entity1 following injection of @entity3 (2.0   mg/kg) and/or nicotine (0.2 or 0.4   mg/kg) daily for 7 days. @entity3 was then discontinued and all @entity1 received nicotine (0.2 and 0.4   mg/kg) and @entity3 (2.0   mg/kg) on three challenge days. @entity3 acutely decreased 50   kHz vocalizations, whereas repeated nicotine potentiated rates of vocalizations, with similar patterns during light presentations. @entity1 in the @entity3 and nicotine combination groups made more 50   kHz vocalizations compared with @entity1 in the control groups on challenge days. We conclude that @entity3 may produce a reward deficit, which is shown by decreased 50   kHz USVs, and behaviors post- @entity3 exposure may best model the comorbidity between @entity2 and nicotine.

title: Effects of the phencyclidine model of @entity2 and nicotine on total and categorized ultrasonic vocalizations in XXXX .

answer: @entity1


abstract: @entity10 ( @entity10 ) is the most prevalent form of @entity3 , characterized by recurrent complex partial @entity4 and @entity2 . The pathophysiology underlying this disorder remains unidentified. While a loss of @entity6 binding sites is a key diagnostic feature of @entity10 , experimental studies have shown enhanced inhibitory transmission and increased expression of @entity7 (A)-receptors, suggesting that compensatory mechanisms are operative in @entity3 hippocampus. In the present study, changes in the expression and cellular distribution of major @entity7 (A)-receptor subunits were investigated in the hippocampus of @entity11 -treated @entity1 during the phase of spontaneous recurrent @entity4 . A uniform decrease in @entity7 (A)-receptor subunit-immunoreactivity was observed in regions of extensive @entity5 (i.e. @entity8 , @entity9 , hilus). whereas a prominent increase occurred in the dentate gyrus (DG). Most strikingly, the increase was largest for the alpha3- and alpha5-subunits, which are expressed at very low levels in the DG of control @entity1 , suggesting the formation of novel @entity7 (A)-receptor subtypes in @entity3 tissue. Furthermore, an extensive loss of interneurons expressing the alpha1-subunit, representing presumptive basket cells, was seen in the DG. These changes were very similar to those reported in a novel @entity0 model of @entity10 , based on the unilateral injection of @entity12 into the dorsal hippocampus (Bouilleret et al., 1999). This indicates that the regulation of @entity7 (A)-receptor expression is related to @entity4 , and is not due to the extrahippocampal @entity5 affecting @entity11 -treated @entity1 . These results allow causal relationships in the induction and maintenance of @entity4 to be distinguished. The loss of a critical number of interneurons in the DG is a possible cause of @entity4 initiation, whereas the long-lasting upregulation of @entity7 (A)-receptors in granule cells represents a compensatory response to @entity4 activity.

title: GABAergic neurons and XXXX (A)-receptors in @entity10 .

answer: @entity7


abstract: BACKGROUND: @entity2 ( @entity2 ) is the third leading cause of @entity1 deaths worldwide. We tested @entity7 (MA) against placebo in the treatment of advanced @entity2 . METHODS: From 2002 through 2007, this randomised double-blind trial enrolled 204 @entity0 with treatment-naive advanced @entity2 (Eastern Cooperative Oncology Group (ECOG) performance rating of 0-3) from specialist care centres in six Asia-Pacific nations. @entity0 received placebo or MA (320 mg day(-1)). End points were @entity6 ( @entity6 ) and quality of life. RESULTS: An adverse but not statistically significant difference in @entity6 was found for MA vs placebo: median values 1.88 and 2.14 months, respectively (hazard ratio (HR)=1.25, 95% CI=0.92-1.71, P=0.16). However, @entity6 was similar among @entity0 of good functional status ( @entity0 -Pugh A and ECOG 0, 1 or 2) (44.3%) in both treatment groups, with the adverse effect of MA confined to those of poor status. @entity7 @entity0 had a worse global health status (not statistically significant) but reduced levels of @entity5 and @entity3 / @entity4 . CONCLUSION: @entity7 has no role in prolonging @entity6 in advanced treatment-naive @entity2 . Overall survival with placebo differed markedly from that in similar trials conducted elsewhere, suggesting therapeutic outcomes may be strongly dependent on ECOG status and @entity0 -Pugh score.

title: Randomised double-blind trial of XXXX vs placebo in treatment-naive advanced @entity2 .

answer: @entity7


abstract: We present three @entity0 with neurologic complications of the spine from @entity1 . The first was a 6-year-old @entity0 with lower limb @entity3 evolving over 2 weeks. Neuroimaging revealed a cystic mass compressing the spinal cord at the level of T8 and extending from the vertebral body. She underwent surgical decompression. Histopathologic examination confirmed @entity1 . At 6-month follow-up, functional improvement had occurred with full ambulation. She continues on long-term albendazole therapy. Two other @entity0 are described, one with primary @entity1 and the other with @entity2 and secondary seeding to the spine. Spinal @entity1 is a rarity, even more so in @entity0 . Although @entity1 , primarily affecting bone, carries a poorer long-term outlook, the first @entity0 made a dramatic recovery and has raised therapeutic dilemmas as to the total duration of continuing albendazole therapy. The literature documents some 37 reports, mostly in adults. Considering the frequency of @entity1 in South Africa, the incidence in our population could be under-recorded. Unless the clinician includes spinal @entity1 , in endemic areas, as part of the differential list for @entity3 and considers performing neuroimaging, this potentially treatable diagnosis will be missed.

title: Hydatid disease of the spine in South African XXXX .

answer: @entity0


abstract: INTRODUCTION: @entity0 information leaflets (PILs) are an important source of information for @entity0 postoperatively. There are currently no nationally agreed standards by dermatologists for postoperative advice following skin surgery. AIM: To assess the common themes and areas of variation in advice given in PILs after skin surgery across all @entity3 ( @entity3 ) hospitals in England and Wales. METHODS: All acute trusts in England (n  =  159) and local health boards in Wales (n  =  7) were requested to provide their postoperative dermatological PILs for general sutured wound care or excision biopsy. Eight preselected parameters were assessed: minimum dressing duration, duration of pressing on a @entity4 wound, @entity1 , explanation of @entity2 signs, application of petroleum jelly, scarring, whom to contact if there is a problem, and the recommended postoperative time for abstaining from active exercise. RESULTS: PILs were received from 137 different dermatology departments belonging to 127/166 (76.5%) organisations across England and Wales. Of these, 102 PILs gave a specific duration for dressings: 45/102 (44.1%) advised a minimum of 48  h, but 28/102 (27.5%) recommended leaving dressings in place until suture removal. Regarding duration of pressing on a @entity4 wound, 117 PILs gave advice, with the most common recommendation being 15  min (30/117, 25.6%), followed closely by 10  min (26/117, 22.2%). Of the 137 PILs received, 125 gave advice regarding @entity1 , with @entity5 alone being the most common recommendation (24/125, 19.2%). For the remaining parameters, 111/137 (81.0%) PILs described >=   2 signs of @entity2 , 42/137 (30.7%) recommended the application of petroleum jelly, 65/137 (47.4%) mentioned scarring, 137/137 (100%) highlighted whom to contact if there were postoperative problems and 87/137 (63.5%) PILs gave advice regarding postoperative abstinence from active exercise. CONCLUSIONS: The advice given in dermatology postoperative PILs across England and Wales is highly variable. A nationally agreed template or set of postoperative advice should be considered to improve consistency.

title: Dermatological postoperative XXXX information leaflets: is it time for more uniformity?

answer: @entity0


abstract: Over the last three decades, @entity2 ( @entity2 ) of childhood has turned from a once fatal condition into a disease that can be cured in about two-thirds of @entity0 . Nevertheless, about 30% of these @entity0 relapse with a dismal prognosis. Achievement of complete remission is an essential step in successful therapy. However, @entity0 in complete remission as defined by morphologic criteria can still harbor more than 10(9) leukemic cells. We have recently shown that @entity1 is detected in most @entity0 after completion of therapy. The amount of persistent 'indolent' disease that is actually present in a particular @entity0 and the degree to which it must be reduced to maintain a long-term remission is largely unknown. In order to address this question, and hence to tailor efficient therapy in accordance with the needs of the individual @entity0 , a multitude of techniques for the detection of @entity1 have been developed over the last few years. The most commonly used techniques are the polymerase chain reaction (PCR) assays. These sensitive assays have revolutionized this area of research. The heterogeneity of the results obtained, however, still precludes widespread clinical applicability of these techniques.

title: @entity1 in XXXX of childhood: methods of detection and clinical relevance.

answer: @entity2


abstract: BACKGROUND: The relationship between coping styles and @entity1 has received considerable attention and instruments have been developed to assess coping strategies. The measurement by means of category systems has been criticized and a functional hierarchy of action types linked to the adaptive processes is preferred. We aimed to determine which factors may exist within the Brief- @entity4 (Brief Coping Orientation to Problems Experienced - @entity4 - Inventory) in an Italian sample of @entity0 with @entity2 ; and if these factors correlate with the severity of psychopathology or with other characteristics. METHODS: A total sample of 148 @entity0 was recruited. The Brief- @entity4 inventory, the Symptom Check List 90-Revised, the Penn State Worry Questionnaire, the Zung @entity2 Status Inventory and the Zung Self-Rating @entity2 Scale were administered. RESULTS: Factor analysis of the Brief- @entity4 yielded nine factors accounting for 65.48% of the variance. @entity0 scored higher on Searching Support, followed by Acceptance, Changing Perspective, and Problem Solving. Associations between measures of psychopathology and factors of coping strategies, mostly Searching support and Avoidance, were found. CONCLUSIONS: Data of the present study support a nine-factor structure of the Brief- @entity4 that includes five broad dimensions of coping. Psychopathology was mostly related to Searching support and Avoidance factors, showing that these strategies may reflect ineffective ways of coping; Problem solving and Changing perspective could be a valid approach to moderate @entity2 / @entity3 symptoms and psychopathology in general.

title: Coping strategies in a sample of @entity2 XXXX : factorial analysis and associations with psychopathology.

answer: @entity0


abstract: Abstract During hovering flight, animals can increase the wing velocity and therefore the net aerodynamic force per @entity0 by increasing wingbeat frequency, @entity0 , or both. The magnitude and orientation of aerodynamic forces are also influenced by the geometric angle of attack, timing of wing rotation, wing contact, and pattern of deviation from the primary @entity0 plane. Most of the kinematic data available for flying animals are average values for @entity0 and wingbeat frequency because these features are relatively easy to measure, but it is frequently suggested that the more subtle and difficult-to-measure features of wing kinematics can explain variation in force production for different @entity1 . Here, we test this hypothesis with multicamera high-speed recording and digitization of wing kinematics of @entity2 ( @entity2 ) hovering and ascending in air and hovering in a hypodense gas (heliox: 21% O2, 79% He). @entity2 employed @entity0 (86.7      7.9  ) and high wingbeat frequencies (226.8    12.8 Hz) when hovering in air. When ascending in air or hovering in heliox, @entity2 increased @entity0 amplitude by 30%-45%, which yielded a much higher wing tip velocity relative to that during simple hovering in air. Across the three flight conditions, there were no statistical differences in the amplitude of wing @entity0 deviation, minimum and @entity0 -averaged geometric angle of attack, maximum wing rotation velocity, or even wingbeat frequency. We employed a quasi-steady aerodynamic model to estimate the effects of wing tip velocity and geometric angle of attack on lift and drag. Lift forces were sensitive to variation in wing tip velocity, whereas drag was sensitive to both variation in wing tip velocity and angle of attack. @entity2 utilized kinematic patterns that did not maximize lift production but rather maintained lift-to-drag ratio. Thus, our data indicate that, at least for @entity2 , the overall time course of wing angles is generally preserved and modulation of wing tip velocity is sufficient to perform a diverse set of vertical @entity1 .

title: Hovering Flight in the @entity2 XXXX : Kinematic Mechanisms for Varying Aerodynamic Forces.

answer: @entity2


abstract: OBJECTIVES: to identify organisational determinants of adherence to evidence-based drug treatments after @entity1 ( @entity1 ), under the hypothesis that low adherence is associated with higher mortality and risk of reinfarction. In particular, we investigated the effect of group vs. single handed practice and multi-professional practice characteristics on @entity0 ' adherence to polytherapy after @entity1 . DESIGN: retrospective cohort study. SETTING AND @entity0 : residents in the Local Health Authority of Bologna (Italy) who were discharged from any Italian hospital between 2008 and 2011 with a diagnosis of @entity1 , and followed-up for a year. MAIN OUTCOME MEASURES: adherence to at least three out of the four drug therapies recommended for secondary prevention of @entity1 ( @entity2 , b-blockers, antiplatelet agents, @entity3 ). @entity0 who had at least 80% of days of follow-up covered by drug doses were considered adherent. RESULTS: of the 4,828 post- @entity1 @entity0 , 31.6% were adherent to polytherapy. General practice characteristics were unrelated to adherence, whereas discharge from cardiology hospital wards was significantly associated with higher @entity0 ' adherence (OR 1.97; 95%CI 1.56-2.48). CONCLUSION: general practice organisational models are not associated with higher adherence to evidence-based medications after @entity1 , whereas cardiologists seem to play a key role in improving @entity0 adherence to polytherapy. Healthcare delivery models should be designed; in them, general practitioners are responsible for the provision of @entity0 -centred care pathways and for care co-ordination with other primary care professionals and specialists, and take an advocacy role for the @entity0 when needed.

title: [Organisational determinants of adherence to secondary prevention medications after XXXX ].

answer: @entity1


abstract: AIMS: To investigate the association between estimated glomerular filtration rate (eGFR) and total and @entity3 in a population-based cohort of @entity1 subjects. METHODS: A longitudinal study using a population-based district @entity1 register comprising 3288 subjects in South Tees, UK. The eGFR was calculated using the @entity2 ( @entity2 ) study equation. @entity0 were stratified by baseline eGFR into five stages as per the National Kidney Foundation guidelines: Stage 1, eGFR > 90; Stage 2, eGFR 60-89; Stage 3, eGFR 30-59; Stage 4, eGFR 15-29; and Stage 5, eGFR < 15 ml/min per 1.73 m(2). Main outcome was all-cause and @entity3 between 1 January 1994 and 31 July 2004. RESULTS: At baseline, mean age (58.4 years) differed between groups. @entity0 with lower eGFR were older (P < 0.001). Thirty-six percent (n = 1193, males 56%) had died by 10 years (cardiovascular cause in 60%). Median follow-up was 10.5 years amounting to 28 342 @entity0 years. Stages 4 and 5 (eGFR <or= 29 ml/min per 1.73 m(2)) were amalgamated for mortality analysis. Total and @entity3 increased with reduced eGFR. @entity4 (HR) [95% confidence interval (CI)] for all-cause mortality comparing groups 2 and 3, and 4 and 5 combined with group 1 were 1.28 (1.02, 1.60), 2.58 (2.05, 3.25) and 6.42 (4.25, 9.71), respectively. Adjusted HRs (95% CI) for mortality due to circulatory disease comparing groups 2 and 3, and 4 and 5 combined with group 1 were 1.50 (1.10, 2.06), 3.32 (2.41, 4.58) and 7.99 (4.69, 13.62), respectively. CONCLUSIONS: In @entity1 subjects, mortality increases significantly with reduced GFR. Low eGFR identifies @entity0 at high risk of @entity3 who should be targeted for aggressive risk factor modification.

title: All-cause and @entity3 in @entity1 subjects increases significantly with reduced estimated glomerular filtration rate (eGFR): 10 years' data from the South Tees XXXX study.

answer: @entity1


abstract: We examined the relationship between a researcher-rated and a self-report method of insight assessment in @entity0 with @entity2 . Previous research has established that a moderate correlation exists between several researcher-rated and self-report insight scales. Hence, we wanted to investigate this association using another combination of assessment techniques. Accordingly, 34 @entity0 with chronic @entity2 were administered the Scale to Assess Unawareness of @entity1 (SUMD) and the Birchwood self-report Insight Scale (IS). We found a significantly lower report of insight on the Birchwood IS, regardless of administration order. These findings suggest that inherent bias within the @entity0 -examiner interaction may be responsible for this discrepancy. Overall, a significant positive correlation was observed between total scores on the SUMD and the Birchwood self-report IS. Unexpectedly, there was a remarkable difference in correlation with respect to the order of test administration. The "self-report first" group's scores were strongly correlated, whereas the "researcher-rated first" group's scores showed little relation. These results demonstrate the importance of investigating the effects of administration order, and also question the reliability of other correlational studies between researcher-rated and self-report insight scales that have failed to employ a counterbalanced research design.

title: A comparison between an interview and a self-report method of insight assessment in chronic XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate the efficacy and tolerability of a combination of @entity12 (VNR) and @entity11 ( @entity17 ) as first-line chemotherapy in @entity1 with metastatic @entity0 . @entity1 AND METHODS: The study group comprised 40 @entity1 with untreated metastatic @entity0 with visceral (85%) and bone (70%) metastases. Of the 40 @entity1 , 24 (60%) had previously received adjuvant chemotherapy, which had included anthracyclines in 12 @entity1 (30%). Treatment consisted of VNR 25 mg/m(2) on days 1 and 5, and @entity17 75 mg/m(2) on day 1 every 3 weeks. Depending on the neutrophil nadir (grade 3 or 4 @entity14 by WHO criteria) recombinant @entity1 @entity13 ( @entity13 ) 5 micro g/kg on days 2-4 and 6-13 was given for all subsequent treatment cycles. RESULTS: The overall response rate (ORR) was 40% (95% confidence interval, CI 15-65). Six @entity1 (15%) achieved a complete response (CR) and ten @entity1 (25%) achieved a partial response (PR). @entity2 ( @entity2 ) was observed in six @entity1 (15%), and 18 @entity1 (45%) had @entity3 ( @entity3 ). The median duration of response was 8 months and the median predictive @entity10 ( @entity10 ) was 6 months. The main @entity4 was @entity14 grade 3 and 4 in 28 @entity1 (70%). @entity14 requiring hospitalization occurred in 12 @entity1 (30%). Grade 3 or 4 @entity8 was seen in two @entity1 (5%) and grade 3 or 4 @entity9 was seen in one @entity1 (2.5%). Severe nonhematologic @entity4 , except @entity15 , was uncommon and included @entity16 in two @entity1 (5%), @entity7 in two (5%) and @entity6 in one (2.5%). There were no treatment-related @entity5 . CONCLUSIONS: The combination of VNR and @entity17 at the doses used in this study showed moderate activity as first-line chemotherapy in metastatic @entity0 . @entity14 was considerable despite @entity13 administration.

title: XXXX and @entity11 as first-line chemotherapy in metastatic @entity0 .

answer: @entity12


abstract: We investigated the in vivo and in vitro effects of lipopolysaccharide (LPS) treatment (4 mg/kg i.p.) on @entity2 airway smooth muscle reactivity and epithelial bioelectric responses to @entity5 (MCh) and @entity4 . Hyperosmolar challenge of the epithelium releases epithelium-derived relaxing factor (EpDRF). Using a two-chamber, whole body plethysmograph 18 h post-treatment, animals treated with LPS were hyporeactive to inhaled MCh aerosol. This could involve an increase in the release and/or actions of EpDRF, because LPS treatment enhanced EpDRF-induced smooth @entity0 in vitro in the isolated perfused @entity1 apparatus. In isolated perfused tracheas the basal transepithelial potential difference (Vt) was increased after LPS treatment. The increase in Vt was inhibited by @entity7 and @entity6 . Concentration-response curves for changes in Vt in response to serosally and mucosally applied MCh were biphasic (hyperpolarization, <3 x 10(-7)M; depolarization, >3 x 10(-7)M); MCh was more potent when applied serosally. The hyperpolarization response to MCh, but not the depolarization response, was potentiated after LPS treatment. In both treatment groups, mucosally applied hyperosmolar solution (using added @entity3 ) depolarized the epithelium; this response was greater in tracheas from LPS-treated animals. The results of this study indicate that airway hyporeactivity in vivo after LPS treatment is accompanied by an increase in the release and/or actions of EpDRF in vitro. These changes may involve LPS-induced bioelectric alterations in the epithelium.

title: Hyperosmolar solution effects in XXXX airways. IV. Lipopolysaccharide-induced alterations in airway reactivity and epithelial bioelectric responses to @entity5 and @entity4 .

answer: @entity2


abstract: BACKGROUND: This study sought to evaluate the predictors of @entity1 in the 2012 international consensus guidelines for @entity4 ( @entity4 ) and validate their diagnostic value relative to the 2006 guidelines. METHODS: Between 2002 and 2014, 177 consecutive @entity0 who underwent curative resection of IPMN were reviewed. Based on the 2012 guidelines, high-risk stigmata (mural nodule with enhancement, main pancreatic duct [MPD]  >=   10  mm, and @entity3 ) and worrisome features (cyst size  >=   30  mm, thickened cyst wall, mural nodule without enhancement, MPD 5-9  mm, an abrupt change in MPD diameter, and @entity2 ) were assessed, and predictive and diagnostic values were analyzed statistically. RESULTS: Multivariate analysis identified @entity3 (odds ratio [OR], 23.9; P  <  .0001), abrupt change in MPD diameter (OR, 3.01; P  =  .017) and @entity2 (OR, 5.84; P  =  .027) as independent predictive factors, with an accuracy of 69.8, 67.4, and 66.3%, respectively. Operative intervention was indicated in 156 @entity0 (94.0%) using the 2006 guidelines, and in 130 (78.3%) using the 2012 guidelines. The accuracy of the 2006 guidelines was 35.5% compared with 44.8% for the 2012 guidelines. The area under the curve (AUC) for the 2006 and 2012 guidelines was 0.65 and 0.67, respectively;   AUC was 0.02, which was not statistically significant. When the worrisome features were combined with high-risk stigmata, the AUC increased to 0.79. CONCLUSION: @entity3 , abrupt change in MPD diameter, and @entity2 were independent predictive factors in the 2012 guidelines with high accuracy. Using the new guidelines, the number of @entity0 with IPMN managed with observation and the predictive accuracy increased.

title: Comparison of the international consensus guidelines for predicting XXXX in @entity4 .

answer: @entity1


abstract: BACKGROUND: Gyrification is an important index of brain development. We used magnetic resonance scanning technology to compare brain surface morphology and measures of gyrification in @entity0 and adolescents with a @entity2 spectrum disorder and in age-equivalent healthy controls. METHODS: Magnetic resonance scans were obtained from 42 @entity0 and 24 healthy controls, mean age 17.7 years for both groups. We employed novel quantitative measures of brain morphology, including cortical @entity1 and a variety of indices of sulcal and gyral curvature. We examined these measures in the whole brain and in the frontal, temporal, parietal, and occipital lobes. RESULTS: There were significant decreases in cortical @entity1 in the @entity0 . This was most pronounced in the cortical tissue that underlies the sulci. The @entity0 group had significantly more flattened curvature in the sulci and more steeped or peaked curvature in the gyri. CONCLUSIONS: This study quantitatively examines cortical @entity1 and surface morphology in @entity0 and adolescents with @entity2 . @entity0 with @entity2 demonstrated patterns of brain morphology that were distinctly different from healthy controls. In light of current theories of the formation of gyri and sulci, these changes may reflect aberrations in cerebral and subcortical connectivity.

title: Gyrification abnormalities in childhood- and adolescent-onset XXXX .

answer: @entity2


abstract: Bortezomib, @entity2 and @entity3 can be aimed at treating @entity0 with newly diagnosed multiple @entity1 (both eligible and ineligible for transplantation) as well as those with relapsed or refractory disease. This review analysed the available clinical and economic data on these three drugs. Irrespective of which of the three agents is considered, the magnitude of the benefit in newly diagnosed cases (transplanted or non-transplanted) tends to be between 10 and 20 months per @entity0 in terms of progression-free survival or survival; the survival benefit is smaller in relapsed or refractory disease. In addition, a single-institution observational analysis evaluated the outcomes in nearly 3000 consecutive @entity0 examined between 1971 and 2006. The survival in @entity0 diagnosed between 2001 and 2006 was longer than that observed in @entity0 diagnosed between 1994 and 2000. This finding supports the conclusion that novel agents provide a survival improvement compared with traditional therapy. Formal cost-effectiveness studies on these three agents are still lacking. A MEDLINE search retrieved only four short papers or letters and no full-length analysis. Hence, the cost effectiveness of these agents needs further investigation, with separate assessments of the different therapeutic settings. In a simplified analysis, we tried to contrast the average cost of treatment for each of the novel agents versus their respective benefit, expressed in quality-adjusted survival. Despite its preliminary nature, our assessment indicates that the cost effectiveness of these three agents is likely to be within commonly accepted pharmacoeconomic thresholds.

title: The role of bortezomib, @entity2 and XXXX in the management of multiple @entity1 : an overview of clinical and economic information.

answer: @entity3


abstract: UNASSIGNED: The effects of dietary @entity3 (VA) supplementation on reproductive performance, VA deposition, and potential mechanisms of action were studied in Chinese yellow-feathered broiler breeders. A total of 528 yellow-feathered broiler breeders that were 46 wk old were fed a @entity6 - @entity4 meal basal diet supplemented with 0; 5,400; 10,800; or 21,600 IU/kg VA for 9 wk. Each dietary treatment had 6 replicates with 22 birds per replicate. After 7 wk of treatment, 60 settable eggs per replicate were collected for hatching. The results showed that dietary VA improved the laying rate, egg-to-feed ratio, and hatch weight of offspring (P < 0.05). Hepatic @entity7 in broiler breeders and hatchlings (within 12 h) increased with increasing VA (P < 0.05). VA supplementation @entity2 factor 1 (IGF-I) receptor transcripts in the @entity0 and the walls of yellow follicles, follicle stimulating hormone (FSH) receptor expression in the walls of white and yellow follicles, and luteinizing hormone (LH) receptor and growth hormone (GH) receptor transcripts in the walls of yellow follicles (P < 0.05). Caspase-3 and Fas mRNA levels in the @entity0 and the walls of white and yellow follicles decreased with VA supplementation (P < 0.05). The relative expression of @entity3 dehydrogenase 10 (RDH10) transcripts in the walls of white follicles increased with 5,400 IU/kg VA supplementation (P < 0.05). Supplemental 21,600 IU/kg VA increased cytochrome P450 26A1 (CYP26A1) transcripts in the @entity0 and the walls of white follicles (P < 0.05). Dietary VA elevated @entity5 receptor a (RARa) expression in the @entity0 and the walls of yellow follicles and @entity1 X receptor a (RXRa) expression in the walls of yellow follicles. It was concluded that VA supplementation improved reproductive performance and hepatic storage of VA, and this was associated with the regulation of ovarian hormone receptor expression and suppression of apoptosis gene transcripts through its active metabolite @entity5 (RA). The optimal dietary VA level for Chinese yellow-feathered broiler breeders at 46 to 54 wk of age was found to be 10,800 IU/kg.

title: Dietary XXXX supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders.

answer: @entity3


abstract: UNASSIGNED: @entity1 ( @entity1 ) can induce remodeling of multiple levels of the cerebral cortex system especially in the sensory cortex. The aim of this study was to assess, in vivo and bilaterally, the remodeling of dendritic spines in the hindlimb representation of the sensory cortex after spinal cord hemisection. @entity2 -YFP @entity0 were randomly divided into the control group and the @entity1 group, and the spinal vertebral plates (T11-T12) of all @entity0 were excised. Next, the left hemisphere of the spinal cord (T12) was hemisected in the @entity1 group. The hindlimb representations of the sensory cortex in both groups were imaged bilaterally on the day before (0d), and three days (3d), two weeks (2w), and one month (1m) after the @entity1 . The rates of stable, newly formed, and eliminated spines were calculated by comparing images of individual dendritic spine in the same areas at different time points. In comparison to the control group, the rate of newly formed spines in the contralateral sensory cortex of the @entity1 group increased at three days and two weeks after injury. The rates of eliminated spines in the bilateral sensory cortices increased and the rate of stable spines in the bilateral cortices declined at two weeks and one month. From three days to two weeks, the stable rates of bilaterally stable spines in the @entity1 group decreased. In comparison to the control group and contralateral cortex in the @entity1 group, the re-emerging rate of eliminated spines in ipsilateral cortex of the @entity1 group decreased significantly. The stable rates of newly formed spines in bilateral cortices of the @entity1 group decreased from two weeks to one month. We found that the remodeling in the hindlimb representation of the sensory cortex after spinal cord hemisection occurred bilaterally. This remodeling included eliminating spines and forming new spines, as well as changing the reorganized regions of the brain cortex after the @entity1 over time. Soon after the @entity1 , the cortex was remodeled by increasing spine formation in the contralateral cortex. Then it was remodeled prominently by eliminating spines of bilateral cortices. Spinal cord hemisection also caused traditional stable spines to become unstable and led the eliminated spines even more hard to recur especially in the ipsilateral cortex of the @entity1 group. In addition, it also made the new formed spines unstable.

title: Remodeling the Dendritic Spines in the Hindlimb Representation of the Sensory Cortex after Spinal Cord Hemisection in XXXX .

answer: @entity0


abstract: Endoplasmic reticulum (ER) stress and inappropriate adaptation through the unfolded protein response (UPR) are predominant features of pathological processes. However, little is known about the link between ER stress and @entity2 . We investigated the involvement of ER stress in @entity5 after @entity4 . The femoral arteries of 7-8-week-old male @entity1 were subjected to wire-induced @entity4 . After 4 weeks, immunohistological analysis showed that ER stress markers were upregulated in the @entity8 . @entity8 formation was increased by 54.8% in @entity6 ( @entity6 ) heterozygous @entity1 , a model of compromised UPR. Knockdown of @entity7 in @entity0 coronary artery smooth muscle cells (CASMC) in vitro promoted cell proliferation and migration. Furthermore, treatment with ER stress reducers, @entity9 ( @entity10 ) and @entity11 ( @entity11 ), decreased the intima-to-media ratio after wire injury by 50.0% and 72.8%, respectively. Chronic stimulation of CASMC with PDGF-BB activated the UPR, and treatment with @entity10 and @entity11 significantly suppressed the PDGF-BB-induced ER stress markers in CASMC and the proliferation and migration of CASMC. In conclusion, increased ER stress contributes to @entity8 formation after @entity4 , while UPR signaling downstream of @entity6 plays a suppressive role. Suppression of ER stress would be a novel strategy against @entity3 .

title: Reduction of endoplasmic reticulum stress inhibits @entity8 formation after XXXX .

answer: @entity4


abstract: OBJECTIVE: The present research examined the impact of @entity2 motives on @entity1 outcomes. METHODS: The sample included 403 daily smokers (214 males, mean age 35.24 years). A bifactor model of @entity2 motives was examined to determine whether this approach might best elucidate relations between @entity2 motives and smoking. RESULTS: Coping motives were associated with reduced barriers for smoking, fewer negative smoking expectancies, and decreased positive reinforcement with respect to smoking. Conformity motives were associated with fewer internal smoking barriers. Expansion motives were associated with more positive reinforcement related to smoking. Enhancement motives were associated with reductions in smoking for appetite/weight control consequences. The general motives variable, comprised of each of the five motives subscales, was associated with more barriers related to @entity1 addiction, more external barriers, greater positive reinforcement consequences, and more negative expectancies. Coping motives were negatively associated with quit status, and were positively associated with quit status. CONCLUSIONS: Cannabis motives subscales were not uniformly predictive of quit success. Individuals who used @entity2 for conformity reasons were more likely to successfully quit smoking, however, individuals who used @entity2 for coping reasons were less likely to quit smoking. Thus, those who use @entity2 for conformity reasons are less likely to turn to @entity2 during times of stress or to relieve @entity3 or @entity0 , a view supported by existing literature. This suggests that individuals who use @entity2 for coping reasons may represent a population vulnerable to @entity2 misuse and problems. Additional work is needed to better understand underlying mechanisms.

title: Cannabis Motives and Quitting XXXX : Smoking Expectancies and Severity among Treatment-seeking Cigarette Smokers.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: @entity2 Autogel(  ) ( @entity2 Depot in the USA) has demonstrated anti- @entity1 activity and control of the symptoms associated with hormone hypersecretion in @entity0 with @entity1 . The objectives of this study were to describe the pharmacokinetics of @entity2 Autogel(  ) administered 4-weekly by deep subcutaneous injections of 60, 90, or 120  mg in @entity0 with @entity1 ( @entity1 ), to quantify the magnitude of inter- @entity0 variability (IPV), and to identify those @entity0 characteristics that impact on pharmacokinetics. METHODS: Analyses were based on pooled data from clinical trials. A total of 1541 serum concentrations from 290 @entity0 were analyzed simultaneously by the population approach using NONMEM(  ) version  7.2. Covariates evaluated included demographics, renal and hepatic function markers, and disease-related parameters. RESULTS: Serum profiles were described by a one-compartment disposition model in which the absorption process was characterized by two parallel pathways following first- and zero-order kinetics. The estimated apparent volume of distribution was 18.3  L. The estimated apparent total serum clearance for a typical 74  kg @entity0 was 513  L/day, representing a substantial difference in clearance in this population of @entity0 with respect to healthy volunteers that could not be explained by any of the covariates tested. Body weight was the only covariate to show a statistically significant effect on the pharmacokinetic profile, but due to the overlap between the pharmacokinetic profiles of @entity0 with lower or higher body weights the effect of body weight on clearance was not considered clinically relevant. The IPV was low for clearance (27  %) and moderate to high for volume of distribution (150  %) and the absorption constant (61  %). CONCLUSIONS: Using two mechanisms of absorption, the pharmacokinetics of @entity2 Autogel(  ) were well-described in @entity0 with GEP-NET. None of the @entity0 characteristics tested were of clinical relevance to potential dose adjustment in clinical practice.

title: Population Pharmacokinetic Analysis of XXXX Autogel(  )/Depot in the @entity1 : Pooled Analysis of Four Clinical Trials.

answer: @entity2


abstract: BACKGROUND: @entity8 is commonly associated with the hypermetabolic stress response. However, persistent @entity8 may adversely affect wound healing and immunity. The purpose of this study was to assess any relationship between @entity8 and clinical outcome after severe @entity1 . METHODS: Survey of the medical records from January 1996 to July 1999 identified 58 pediatric @entity0 with burns > or = 60% body surface. @entity0 were categorized as having poor @entity4 control (n = 33) if > or = 40% of all plasma @entity4 determinations were > or = 7.8 mmol/L (140 mg/dL) and compared with @entity0 deemed to have adequate @entity4 control (n = 25) in whom > or = 40% of all @entity4 values were > or = 7.8 mmol/L. RESULTS: Despite similar age, burn size, caloric intake, and frequency of @entity7 , @entity0 categorized with poor @entity4 control had a significantly greater incidence of positive @entity5 (positive @entity5 /length of stay days, 0.42 +/- 0.04 for @entity8 @entity0 vs. 0.30 +/- 0.03 for normoglycemia @entity0 ; mean +/- SEM, p > or = 0.05). This finding was especially prominent for @entity5 positive for @entity3 . @entity8 @entity0 had significantly less percentage of skin graft take than did the normoglycemic @entity0 (percent take/operative procedure, 64 +/- 9 for @entity8 @entity0 vs. 88 +/- 5 for normoglycemia @entity0 ; p < 0.05). Nine @entity0 (27%) with persistent @entity8 died compared with only one @entity2 (4%) in @entity0 with adequate @entity4 control (p > or = 0.05). CONCLUSION: This association between poor @entity4 control, @entity6 / @entity9 , reduced skin graft take, and subsequent mortality in severely burned @entity0 may be related to a @entity8 -induced detriment in antimicrobial defense. Although this report fails to establish cause and effect, these findings suggest that aggressive maneuvers to normalize plasma @entity4 in critically injured @entity0 may be warranted.

title: Association of @entity8 with increased mortality after severe XXXX .

answer: @entity1


abstract: OBJECTIVES: This study sought to evaluate the incidence of @entity3 ( @entity3 ), @entity7 ( @entity7 ), and calcified nodule (CN) using optical coherence tomography (OCT) in @entity0 with @entity5 ( @entity5 ); to compare detailed morphologic plaque characteristics of @entity3 , @entity7 , and CN with optical coherence tomography and intravascular ultrasound; and to compare the post-procedure outcomes among @entity3 , @entity7 , and CN. BACKGROUND: The incidence and detailed morphologic characteristics of @entity3 , @entity7 , and CN in @entity5 @entity0 and their outcome after percutaneous coronary intervention (PCI) are unknown. METHODS: A total of 112 @entity5 @entity0 who underwent PCI within 12 h from symptom onset were included. Both optical coherence tomography and intravascular ultrasound were performed following aspiration thrombectomy. RESULTS: The incidence of @entity3 , @entity7 , and CN was 64.3%, 26.8%, and 8.0%, respectively. @entity7 and CN, compared with @entity3 , had more @entity2 (p  < 0.001 and p  < 0.001) and less thin-cap @entity6 (p  < 0.001 and p  < 0.001) as well as smaller plaque burden (p  = 0.003 and p  = 0.001) and remodeling index (p  = 0.003 and p  < 0.001). @entity7 had greater plaque eccentricity index than @entity3 and CN (p  < 0.001 and p  < 0.001). CN had greater calcified arc and shallower @entity4 than @entity3 (p  < 0.001 and p  < 0.001) or @entity7 (p  < 0.001 and p  < 0.001). More than one-half of CN had negative remodeling. @entity7 had a lower incidence of no-reflow phenomenon after PCI than @entity3 (p  = 0.011). CONCLUSIONS: @entity7 was the underlying mechanism in one-fourth of @entity5 . @entity7 was characterized by @entity2 . CN was characterized by superficial large @entity4 and negative remodeling. @entity7 was associated with less @entity1 after PCI.

title: A Combined Optical Coherence Tomography and Intravascular Ultrasound  Study on Plaque Rupture, Plaque Erosion, and Calcified Nodule in  @entity0 With ST-Segment Elevation XXXX : Incidence, Morphologic Characteristics, and Outcomes After Percutaneous Coronary Intervention.

answer: @entity5


abstract: OBJECTIVE: To study the relationship between 4 components of physical activity and the 12-year incidence of @entity4 ( @entity3 ) among older adults. METHODS: Longitudinal data from 1,678 @entity0 and @entity0 , ages 55-85 years, were collected in the Longitudinal Aging Study Amsterdam. Incident clinical knee @entity3 was defined by an algorithm using self-report and general practitioner data. Physical activity was assessed by a validated questionnaire from which 4 physical activity component scores were created: muscle strength, intensity, mechanical strain, and turning actions. Cox proportional hazards models were conducted to examine the relationship between these scores and incident knee @entity3 and reported as hazard ratios (HRs) with 95% confidence intervals (95% CIs). RESULTS: During 12 years of followup, 463 respondents (28%) developed clinical knee @entity3 . A high mechanical strain score (HR 1.43, 95% CI 1.15-1.77) and a low muscle strength score (HR 1.30, 95% CI 1.01-1.68) were associated with an increased risk of knee @entity3 after adjustment for age, sex, region of living, education, lifetime physical work demands, lifetime general physical activity, body mass index, current total physical activity level, and @entity2 . No association was observed in the intensity and turning actions components. The results were similar for @entity0 and @entity0 , and for @entity1 and nonobese respondents. CONCLUSION: Older adults who perform low muscle strength activities or activities causing high mechanical strain had an increased risk of clinical knee @entity3 . These results suggest that specific components of physical activity may influence the development of knee @entity3 .

title: Physical activity and incident XXXX in older adults.

answer: @entity4


abstract: UNASSIGNED: The objective of the study was to investigate the first-night treatment success of a nasopharyngeal stent compared to standard nCPAP-titration. This is a case series and a single-center study. Eight @entity0 (n  =  8) were selected with @entity2 with a prestudy AHI >= 10. A newly developed nasopharyngeal stent was tested individually versus standard nCPAP-titration. Cardiorespiratory polysomnography was performed on two consecutive nights (random order: stent, nCPAP). The AHI, the number of obstructive @entity3 and @entity4 , the mean @entity1 saturation, and the minimum @entity1 saturation were compared before and after using the nasopharyngeal stent or standard nCPAP. The AHI value before treatment (AHIpre) was 31.1      12.0 (mean      standard deviation). After inserting the AlaxoStent, the mean AHIstent was 19      12.0 compared to mean AHInCPAP 8.2      11.9 with standard nCPAP-titration. Both nasopharyngeal stenting and nCPAP-titration could reduce the mean number of obstructive @entity3 by >94  %. Compared to responder rates of classic surgical interventions like uvulopalatopharyngoplasty or multi-level surgery, the nasopharyngeal stent seems to give a comparable responder rate of 50  %. There were no complications associated with the use of the stent and it was well tolerated by all subjects. Nasopharyngeal stenting widens the range of non-invasive mechanical treatment and seems to be an effective mechanical therapeutic alternative to surgery in nCPAP non-compliant @entity0 with OSA. Careful selection of the @entity0 population is a prerequisite of treatment and therefore it should be reserved for individual cases only.

title: A novel nasopharyngeal stent for the treatment of XXXX : a case series of nasopharyngeal stenting versus continuous positive airway pressure.

answer: @entity2


abstract: We present the prosthesis survival of the 7 most commonly used component types of 522 primary Souter elbow replacements performed in the @entity3 Foundation Hospital during the years 1982-1997. The cohort comprised 370 female and 33 male @entity0 with a mean age of 57 (20-81) years. 119 @entity0 had a bilateral procedure. The indications for operation in all cases were @entity2 and other chronic @entity1 . The mean duration of the disease at the time of operation was 25 (2-70) years. Elbows were often severely destroyed and, in one thiird of the joints, essential bone structures were missing. Therefore, in 178 cases, the ulnar components were retentive and in the remaining 344 elbows with better bone stock non-retentive. 47 @entity0 had 51 operations for @entity4 up to the end of year 2000. In the survival analysis, the general cumulative success rates for the whole study cohort, without revision because of @entity4 5 and10 years after surgery, were 96% and 84%, respectively. Revision was used as an end point. Cumulative success rates of the 7 most commonly used components are presented separately. The highest 5-year-survival rate was 100%, the lowest 93%. The corresponding 10-year-survival rates were 91% and 76%, respectively.

title: Revisions for XXXX in Souter-Strathclyde elbow arthroplasty: incidence of revisions of different components used in 522 consecutive cases.

answer: @entity4


abstract: OBJECTIVE: @entity1 ( @entity1 ) monitoring is frequently used in intensive care treatment of @entity0 with @entity2 . Data demonstrating an improved outcome from this intervention are lacking. We analyzed standardized mortality ratios in @entity0 with and without @entity1 monitoring to determine its efficacy. DESIGN: A nonrandomized study of case records of consecutively admitted intensive care unit (ICU) @entity0 with @entity2 . SETTING: General and medical ICU of a 900-bed tertiary-care hospital. @entity0 : A total of 225 @entity0 with @entity2 (mainly nontraumatic) admitted consecutively between April 1997 and March 2000. MEASUREMENTS: Simplified Acute Physiology Score (SAPS) II, diagnosis, age, sex, use of @entity1 monitoring, and in-hospital mortality rates were collected from the hospital's ICU database. Expected mortality was provided by means of SAPS II. Standardized mortality ratios were calculated and compared in 119 @entity0 with @entity1 monitoring and 106 @entity0 without @entity1 monitoring. MAIN RESULTS: The case mix-adjusted hospital mortality in the group with @entity1 monitoring was in the expected range (standardized mortality ratio, 1.09 [95% confidence interval (CI), 0.87-1.31]). @entity0 without @entity1 monitoring had a significantly higher standardized mortality ratio than expected (1.26 [95% CI, 1.06-1.46]). CONCLUSIONS: A beneficial effect of @entity1 monitoring in @entity0 with @entity2 may be reflected in an improved standardized mortality ratio.

title: @entity1 monitoring and case mix-adjusted mortality in XXXX .

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to determine the best tolerated and efficacious dose of @entity8 given once or twice in 3-week cycles in combination with @entity11 and @entity10 (VMF). @entity1 AND METHODS: @entity8 40 mg/m(2) was given as follows: 20 mg/m(2) on days 1 and 8 (group 1); 30 mg/m(2) on day 1 and 10 mg/m(2) on day 8 (group 2); or 40 mg/m(2) on day 1 (not exeeding 60 mg/m(2)) (group 3). The @entity11 dose was 40 mg/m(2) on day 1 and the @entity10 dose 600 mg/m(2) on days 1 and 8. Thirty @entity1 with evaluable @entity2 were randomly allocated to the groups (first step). The second step was to exclude the worst tolerated regimen and then to expand the study to 60 @entity1 . Thus, group 1 had 26 @entity1 , group 2 had 24 @entity1 and group 3 had 10 @entity1 . RESULTS: World Health Organization (WHO) grade 3 hematological @entity3 occurred in 23%, 36% and 50% of @entity1 and grade 4 in 39%, 32% and 50% of @entity1 in groups 1, 2 and 3, respectively; grade 3 @entity4 were observed in 15%, 9% and 10% of @entity1 in groups 1, 2 and 3, and grade 4 @entity4 in 5% and 10% of @entity1 in groups 2 and 3, respectively. Nonhematological @entity3 included a mild to moderate @entity12 manifesting as @entity7 , abdominal colics and @entity6 in the majority of @entity1 . One @entity1 in group 3 had serious @entity5 after @entity8 administration; she also developed @entity9 ; all symptoms were reversible. No @entity1 died from side-effects. The objective response rates were 50%, 55% and 44% for groups 1, 2 and 3, respectively. Median time to progression was 7, 10 and 8 months and median survival time was 26, 23 and 16 months in groups 1, 2 and 3, respectively. CONCLUSION: VMF regimens where the @entity8 dose (40 mg/m(2)) is divided (20 + 20 mg/m(2) and 30 + 10 mg/m(2)) between days 1 and 8 of a 3-week cycle are equally well tolerated and the efficacy is comparable to other modern first line regimens used in the treatment of metastatic @entity0 .

title: XXXX , @entity11 and @entity10 (VMF) as first-line therapy in metastatic @entity0 : a randomized phase II trial.

answer: @entity8