abstract: @entity6 ( @entity5 ) is a @entity2 -specific PET tracer. In future clinical applications of @entity2 imaging, such as early response monitoring or radiation therapy dose painting, accurate quantification of tracer uptake at the voxel level will be required. The aim of the present study was to assess the validity of parametric methods for the quantification of @entity4 -FAZA studies. METHODS: Dynamic 70-min @entity5 scans were obtained from 9 @entity3 @entity0 . Arterial blood samples, collected at 7 time points, were used for preprocessing an image-derived input function derived from volumes of interest (VOIs) defined within the ascending aorta. Time-activity curves derived from various @entity1 VOIs were fitted using nonlinear regression analysis (NLR) to a reversible 2-tissue-compartment model, providing volumes of distribution (VT) as an outcome measure. Next, parametric images were generated by use of both Logan graphic analysis with various linear regression start times and spectral analysis with multiple sets of basis functions. The previously defined @entity1 VOIs were projected onto these parametric images, and the resulting VT were compared with those obtained from NLR. In addition, the results were compared with @entity1 (SUVr), which are more easily obtainable. RESULTS: The highest correlations and correspondence with NLR-derived VT were found for Logan graphic analysis with a start time of 30 min after injection (R(2), 0.88; intraclass correlation coefficient [ICC], 0.93) and for spectral analysis-derived VT with a set of 30 basis functions with exponents ranging from 0.0175 to 1.9 (R(2), 0.79; ICC, 0.81). SUVr yielded similar correlations but showed significant bias at high VT (R(2), 0.85; ICC, 0.80). CONCLUSION: Both Logan graphic analysis and spectral analysis yielded VT that showed high correlations with nonlinear regression analysis-derived VT. SUVr showed bias at high VT.

title: Parametric Methods for Quantification of XXXX Kinetics in @entity3 @entity0 .

answer: @entity5


abstract: @entity0 papillomaviruses (HPV) are the causative agents of most cervical @entity1 . A complete understanding of the HPV types that cause @entity5 is needed as vaccines are designed. Fresh tissues are not always available for such studies. We therefore sought to determine the feasibility of HPV studies using @entity2 -fixed, @entity3 -embedded sections of 56 cervical @entity1 , correlating typing information with the pathology and physical state of the HPV sequences within cells. Sections from each specimen were used to extract and purify DNA. Specific HPV types were identified using a PCR/reverse blot strip assay. Tyramide signal-amplified, fluorescent DNA in situ hybridization (FISH) was used to localize HPV within cells. @entity0 @entity6 sequences were amplified in DNA from all specimens. HPV sequences from oncogenic types were identified in 52 of 56 (92.9%) by PCR/reverse blot strip assay, and in one additional case using an @entity4 multiplex PCR assay. @entity4 was the most commonly detected type, present in most cases as a solitary isolate. Thirty- five of 42 @entity4 or HPV 18 PCR-positive specimens were also positive in the FISH assay, in most cases in a pattern consistent with viral integration. We conclude that HPV typing from @entity2 -fixed, @entity3 -embedded sections of cervical @entity1 is possible, with a sensitivity that is similar to that found in studies using fresh tissue.

title: Detection of specific human papillomavirus types in XXXX -embedded sections of cervical @entity1 .

answer: @entity3


abstract: Object The authors' institution previously reported a 69% rate of crude local control for surgical management of lateral ventricle @entity2 at the University of Texas @entity9 Anderson @entity3 Center. For comparison, the authors here report their institutional experience with use of stereotactic radiosurgery (SRS) to treat intraventricular @entity2 . Methods To identify @entity1 with intraventricular @entity2 for this retrospective review, the authors queried an institutional SRS database containing the medical records of 1962 @entity1 with 5800 brain @entity2 who consecutively underwent SRS from June 2009 through October 2013. End points assessed were local control (crude and locoregional), distant failure-free survival, progression-free survival, and overall survival. Results Of the 1962 records examined, those for 25 (1.3%) @entity1 with 30 (0.52%) intraventricular @entity2 were identified. Median @entity1 age at SRS was 55.8 years. The most common @entity3 was @entity10 (n = 13), followed by @entity7 (n = 7) and @entity0 (n = 5). Median @entity3 volume was 0.75 cm(3) (range 0.01-5.6 cm(3)). Most lesions were located in the lateral ventricles (n = 25, 83.3%) and were treated to a median dose of 20 Gy (range 14-20 Gy). A total of 12 (48%) @entity1 received whole-brain radiation therapy, most (n = 10) before SRS. With a median follow-up of 11.4 months (range 1.6-39.2 months), the rate of crude local control was 93.3%, and the rates of 6-month and 1-year actuarial locoregional control were 85.2% and 56.2%, respectively. The median overall survival time after SRS was 11.6 months (range 1.3-38.9 months), and the 6-month and 1-year actuarial rates were 87.1% and 46.7%, respectively. Disease dissemination developed in 7 (28%) @entity1 as a second intraventricular metastatic lesion (n = 3, 12%), @entity5 (n = 3, 12%), or both (n = 1, 4%). Radiographic changes developed in 5 (20%) @entity1 and included @entity4 (n = 2, 8%) and @entity8 (n = 3, 12%). A primary diagnosis of @entity10 was associated with an improved rate of distant failure-free survival (p = 0.05) and progression-free survival (p = 0.08). Conclusions SRS provides excellent local control for intraventricular @entity2 , with acceptable treatment-related @entity6 , thereby supporting nonsurgical treatment for these lesions. The propensity for intraventricular dissemination among intraventricular @entity2 seems to be histologically dependent.

title: Stereotactic radiosurgery for intraventricular brain XXXX .

answer: @entity2


abstract: BACKGROUND: Treatment with @entity7 (IM) (a @entity4 kinase inhibitor) is the first line of standard care for @entity0 newly diagnosed with @entity5 . Despite the success of IM and other @entity4 kinase inhibitors (TKIs), @entity5 ( @entity5 ) remains largely incurable, and a number of @entity5 @entity0 die due to @entity6 mutation-related drug resistance and @entity9 . 3, 5-Dihydroxy-6, 7, 3'4'-tetramethoxyflavone (DHTMF) is a polymethoxyflavone isolated from Laggera pterodonta which is a herbal medicine used to treat @entity1 in the Chinese folk. In the previous study, we found DHTMF demonstrated good antiproliferative activities against a number of @entity1 cell lines and induced the apoptosis of CNE cells in vitro in a time- and dose-dependent manner while exhibiting low @entity2 in the two normal cell lines Vero and EVC304. The aim of the present study was to evaluate the proliferation inhibition and apoptosis induced by DHTMF alone and in combination with IM in the IM-resistant @entity5 cell line K562R. METHODS: Cell proliferation was assayed with the cell counting kit-8 (CCK8) method. The apoptosis percentage was determined by flow cytometry (FCM). Mitochondrial transmembrane potential was detected using FCM and confocal laser-scanning microscopy. The level of proteins involved in apoptosis was detected by Western blotting. RESULTS: DHTMF suppressed K562R cell viability in both time- and dose-dependent manners. DHTMF combined with IM enhanced the inhibitory effects and apoptosis in K562R cells as compared with DHTMF alone. DHTMF alone and in combination with IM significantly decreased the mitochondrial membrane potential and increased the levels of cleaved @entity8 , @entity11 , @entity3 , and @entity10 in K562R cells. CONCLUSIONS: We demonstrated that DHTMF could inhibit IM-resistant K562R cell proliferation and induces apoptosis via the intrinsic mitochondrial apoptotic pathway. These results suggest that DHTMF may be a potential therapeutic drug with lower side effects against IM resistance in @entity5 cells.

title: A polymethoxyflavone from Laggera pterodonta induces apoptosis in XXXX -resistant K562R cells via activation of the intrinsic apoptosis pathway.

answer: @entity7


abstract: OBJECTIVES: @entity0 admitted to PICUs often present with or develop @entity4 that requires mechanical ventilation. We prospectively identified @entity0 admitted to three general PICUs, with the goal of identifying risk factors for mortality. DESIGN: Prospective multicenter observational study. SETTING: Three general PICUs, two in S  o Paulo and one in Curitiba, Brazil. @entity0 : @entity0 aged between 1 month and 15 years, consecutively admitted between August 2008 and July 2010, with @entity2 or acute @entity3 that developed at least 12 hours after invasive or noninvasive mechanical ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We used logistic regression models to explore the relationship between @entity1 and independent variables. Of 3,046 @entity0 admitted to the three PICUs, 1,658 @entity0 underwent mechanical ventilation, and 84 fulfilled the @entity2 /acute @entity3 inclusion criteria and were analyzed. Nearly 60% were @entity0 , and the median age was 31 months. Pressure control/assist control was the initial mode of mechanical ventilation in 86% of cases, and the median durations of mechanical ventilation and PICU stay were 12 and 15 days, respectively. None of the eight @entity0 with @entity2 died, whereas 33 of 76 of the remaining @entity0 with acute @entity3 died, for an overall mortality rate of 39.3% (95% CI, 28.8-50.6%). In different multivariate logistic regression model, the number of organ dysfunctions at admission, peak inspiratory pressure, airway pressure gradient on day 1, and the mean airway pressure gradient over the first 7 days of mechanical ventilation were significantly associated with mortality. CONCLUSION: Mortality is high in pediatric @entity2 /acute @entity3 . Mechanical ventilation-associated risk factors for @entity1 among such @entity0 are potential targets for intervention.

title: Risk Factors for Mortality and Outcomes in Pediatric XXXX /Acute @entity3 .

answer: @entity2


abstract: AIMS: This article compares the severity of illness scoring systems clinical risk index for babies (CRIB)-II and score for neonatal acute physiology with perinatal extension (SNAPPE)-II for discriminatory ability and goodness of fit in the same cohort of babies of less than 32 weeks gestation and aims to provide validation in the Australian population. METHODS: CRIB-II and SNAPPE-II scores were collected on the same cohort of preterm @entity0 born within a 2-year period, 2003 and 2004. The discriminatory ability of each score was assessed by the area under the receiver operator characteristic curve, and goodness of fit was assessed by the Hosmer-Lemeshow (HL) test. The outcome measure was in-hospital mortality. A multivariate logistic regression model was tested for perinatal variables that might add to the risk of in-hospital mortality. RESULTS: Data for both scores were available for 1607 @entity0 . Both scores had good discriminatory ability (CRIB-II area under the curve 0.913, @entity1 ( @entity1 ) 0.014; SNAPPE-II area under the curve 0.907, @entity1 0.012) and adequate goodness of fit (HL   (2)    =   11.384, 8 degrees of freedom, P   =   0.183 for CRIB-II; HL   (2)    =   4.319, 7 degrees of freedom, P   =   0.742 for SNAPPE-II). The multivariate model did not reveal other significant variables. CONCLUSIONS: Both severity of illness scores are ascertained during the first 12   h of life and perform similarly. Both can facilitate risk-adjusted comparisons of mortality and quality of care after the first post-natal 12   h. CRIB-II scores have the advantage of being simpler to collect and calculate.

title: Comparing CRIB-II and SNAPPE-II as mortality predictors for very preterm XXXX .

answer: @entity0


abstract: @entity4 ( @entity4 ) are a group of @entity2 arising from mesenchymal stem cells of the gastrointestinal tract. The prognosis of metastatic or recurrent @entity4 is poor, because these @entity2 resist chemotherapy and radiotherapy. We report a @entity0 with recurrent @entity5 who underwent molecularly targeted therapy with @entity7 , a novel oral @entity3 kinase inhibitor. A 50-year-old @entity0 presented with a huge intra-abdominal mass. The @entity0 had a history of gastrectomy for @entity5 and hepatectomy for its metastases. She also underwent surgery for resection of peritoneal metastases 9 months before. The abdominal mass was 26 x 17 x 12 cm in size, as determined by magnetic resonance imaging, and was diagnosed as a peritoneal relapse of @entity5 . Treatment with 400 mg of @entity7 daily was started. After 1 week of treatment with @entity7 , reduction of the @entity2 began to be recognized on palpation. Computed tomographic scanning on day 28 revealed that the @entity2 had liquefactively regressed and had reduced in size by 66%. The major side effect was leg @entity1 , which was easily manageable with @entity6 . The @entity0 has been receiving @entity7 treatment in our outpatient clinic, and the @entity2 regression has continued for 9 months. @entity7 shows promise as a safe and effective drug for the treatment of @entity0 with recurrent @entity4 .

title: A successful case of oral molecularly targeted therapy with @entity7 for peritoneal metastasis of a XXXX .

answer: @entity4


abstract: BACKGROUND: Long-term survival in lung transplant is limited by @entity2 ( @entity2 ). We compared outcomes in pediatric living donor bilateral lobar (LL) vs @entity1 ( @entity1 ). METHODS: @entity0 were studied who had LL or @entity1 with at least 1 year follow-up. Data collected included acute rejection episodes, pulmonary function tests (PFT), @entity2 , and survival. Mean age was 13.36+/-3.16 years in LL and 12.00+/-4.19 years in @entity1 @entity0 (p = 0.37, ns). RESULTS: There was no difference in rejection (p = 0.41, ns). @entity1 had rejection earlier (2.48+/-3.84 months) than LL (13.60+/-10.74 months; p = 0.02). There was no difference in 12 month PFT. But at 24 months, LL had greater forced expiratory volume in 1 second (FEV1) (p = 0.001) and FEF25-71% (p = 0.01) than @entity1 . @entity2 was found in 0/14 LL vs 9/11 (82%) @entity1 after 1 year (p = 0.04). After 2 years, 0/8 LL and 6/7 (86%) @entity1 had @entity2 (p < 0.05). LL had 85% survival vs 79% for @entity1 at 12 months. At 24 months, LL survival was 77% vs 67% for @entity1 . CONCLUSIONS: Pediatric LL had less @entity2 and better pulmonary function than @entity1 . As @entity2 is a determinant of long-term outcome, we believe LL is the preferred lung transplant method for @entity0 .

title: Comparison of outcomes between living donor and cadaveric lung transplantation in XXXX .

answer: @entity0


abstract: INTRODUCTION: @entity4 is a common worldwide problem both in @entity0 and adults. @entity6 as a widely used antibiotic can contribute to the formation of @entity3 and @entity7 . OBJECTIVES: To find the effect of @entity6 , a widely used antibiotic, on urinary @entity1 excretion rate in @entity0 . @entity0 AND METHODS: 84 @entity0 and @entity0 over 3 months admitted to hospital for non-renal problems. They were all previously healthy @entity0 affected with a condition mandating hospitalisation. They were randomly divided into 2 groups; those who received @entity6 according to their physician decision as the case group and those who did not receive antibiotics as the control group. The @entity0 urinary @entity1 excretion was determined as @entity1 to @entity2 ratio in a random urine sample in the first and third day of their admission. All data was expressed by mean    SD and analysed by t independent and chi-square tests by SPSS 16. P P value less than 0.05 was significant. RESULTS: Eighty-four cases were analysed. @entity1 excretion in received and non-received @entity6 groups was 0.13    0.06 and 0.14    0.02 respectively at first day of admission ( P = 0.1). After 3 days, the urine @entity1 to @entity2 ratio increased to 0.27    0.2 and 0.26    0.08 in received and non- received @entity6 groups ( P = 0.8). CONCLUSION: In @entity0 , urinary @entity1 excretion increases 2 times in average in a short time after admission because of @entity5 , and @entity6 is not different to other antibiotics for increase urinary @entity1 excretion in 3 days after admission.

title: XXXX following @entity6 a fact or myth.

answer: @entity7


abstract: The interplay between @entity6 ( @entity3 )-dependent protein kinase A (PKA)- and @entity9 -mediated signaling pathways is expected to determine further loss, maintenance, or modulation of differentiation and proliferation of a particular cell. Therefore, the relationship and nature of the cross-talk between these two major signaling systems are of utmost importance to the understanding of these processes in both normal and neoplastic cells. In view of their paramount physiological importance, one would expect the existence of a well-controlled bidirectional interaction between these pathways, which would be more appropriate and in agreement with basic principles of cellular homeostasis. However, based on the discovery that activated PKA may inhibit ras-mediated translocation of @entity11 to the plasma membrane, it is generally accepted that the cross-talk between @entity3 /PKA and @entity9 -mediated signal transduction pathways is unilateral, i.e., that the activation of PKA regulates growth factor receptor protein @entity4 kinase-mediated signaling. To challenge the validity of a unilateral approach, we decided to test the possible existence of cross-talk of a bidirectional nature between the aforementioned signaling pathways at different stages of malignant differentiation. For that purpose, we investigated the nature of the cross-talk existing between a known receptor protein @entity4 kinase- @entity8 receptor ( @entity12 ) and PKA in highly metastatic and nonmetastatic cloned variants of a @entity2 @entity5 (T-10). Our study revealed the existence of principal differences in PKA activity between metastatic and nonmetastatic cloned @entity5 variants that may be due to the differential expression and membrane translocation of the @entity7 ( @entity10 ) small mass G-protein. Most importantly, our experiments have demonstrated the existence of a novel character of interactions between @entity12 and PKA, because the ligation of the @entity12 by @entity8 in the metastatic variant induced a high activity of PKA. These findings are of prime importance, because they reveal the existence of a new relationship between two major signal transduction pathways in @entity0 cells, i.e., the existence of a bilateral interaction between the ras- and @entity3 /PKA-mediated signal transduction pathways. Furthermore, the fact that two @entity1 cell variants originating in the same @entity1 and differing in their metastatic capacity differ as well in the nature of the cross-talk between major signal generation systems imposes new challenges for the future use of biological response modulators to cure @entity1 and restrict metastatic spread.

title: XXXX regulates protein kinase A activity in @entity2 @entity5 cells: differences between metastatic and nonmetastatic @entity1 cell variants.

answer: @entity8


abstract: UNASSIGNED: 29 Background: The current standard of care for @entity1 for @entity0 who can withstand aggressive therapy is chemotherapy, radiotherapy and surgery (tri-modality therapy). This is the largest study of its kind to date. METHODS: Using the National @entity1 Database (NCDB) 46,758 @entity0 diagnosed with @entity1 between 2000 and 2009 were identified. The NCDB database includes data from 70% of @entity1 @entity0 in the US. RESULTS: In @entity1 private insurance holders received more tri-modality therapy (39%) than @entity2 insurance (18%), Medicaid (22%), Medicare (18%), and the uninsured (19%) (p<0.0001). There was no statistically significant difference in the amount of tri-modality therapy received in @entity0 with @entity2 , Medicare, or no insurance. Medicaid @entity0 received more tri-modality therapy than Medicare, uninsured, and @entity2 @entity0 (p<0.05). @entity2 and uninsured @entity0 received no treatment more frequently (13%) than those with private insurance (5%), Medicare (10%), and Medicaid (9%) (p<0.0003). @entity0 over 70 less frequently underwent tri-modality therapy (13%) as compared to those under 70 (34%, p<0.0001). CONCLUSIONS: Although @entity2 , Medicare, and the uninsured @entity0 received similar rates of tri-modality therapy (18-19%), it was much less than private insurance holders (39%). Medicaid @entity0 received less tri-modality therapy than private insurance holders despite similar ages. Uninsured @entity0 received a similar amount of tri-modality therapy as those with @entity2 and Medicare. [Table: see text].

title: Surgery and chemoradiotherapy in XXXX : A retrospective analysis of first-course treatment across different insurances using the NCDB.

answer: @entity1


abstract: UNASSIGNED: Immune-driven @entity8 primarily affects @entity0 ; the cause for this sex-specific prevalence is unknown. Polymorphonuclear neutrophils (PMN) have distinct phenotypes that @entity2 but also regulate lymphocytes and are the rate-limiting cell for generating anti-inflammatory @entity9 ( @entity9 ). @entity3 regulates the @entity9 circuit to induce delayed female-specific wound healing in the @entity4 . However, the role of PMNs in @entity8 remains unexplored. We discovered an @entity9 -producing tissue PMN population in the corneal limbus, lacrimal glands, and cervical lymph nodes of healthy male and female @entity1 . These tissue PMNs, unlike inflammatory PMNs, expressed a highly amplified @entity9 circuit and were sex-specifically regulated during immune-driven @entity8 . Desiccating stress in females, unlike in males, triggered a remarkable decrease in lymph node PMN and @entity9 formation that remained @entity5 during @entity8 . @entity5 and @entity9 in females correlated with an increase in effector T cells ( @entity7 and Th17), a decrease in regulatory T cells (Treg), and increased @entity6 pathogenesis. Ab depletion of tissue PMN abrogated @entity9 formation in lymph nodes, as well as caused a marked increase in @entity7 and Th17 cells and a decrease in Tregs. To establish an immune-regulatory role for PMN-derived @entity9 in @entity6 , females were treated with @entity9 . @entity9 treatment markedly inhibited @entity7 and Th17 and amplified Treg in draining lymph nodes, while reducing @entity6 pathogenesis. These results identify female-specific regulation of @entity9 -producing tissue PMN as a potential key factor in aberrant effector T cell activation and initiation of immune-driven @entity8 .

title: Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune XXXX .

answer: @entity8


abstract: UNASSIGNED: Hippophae rhamnoides L. commonly known as Seabuckthorn (SBT), a wild shrub of family Elaegnacea, has extensively used for treating various ailments like @entity3 , @entity8 , @entity7 , lung troubles. SBT leaves have been reported to possess several pharmacological properties including immunomodulatory, antioxidant, anti-inflammatory, antimicrobial and tissue regeneration etc. The present study was undertaken to evaluate the adjuvant property of supercritical @entity6 extracts (SCEs 300ET and 350ET) of SBT leaves in balb/c @entity1 immunized with @entity2 and @entity12 toxoids. The dynamic changes in the immune response were measured in terms of humoral and cell-mediated immune responses. We have seen the effect of SCEs on immunoglobulin subtypes and secondary immune response generation. In addition, the effect of SCEs on antigen specific cellular immunity was evaluated. Our results show that SCEs 300ET and 350ET significantly enhanced antibody titers in response to both TT and DT antigens. The secondary immune response generated was significantly increased in case of TT immunized animals. SCEs also enhanced cytokine levels ( @entity5 , @entity11 , @entity4 and @entity10 ) and increased lymphoproliferation. Besides, both SCEs did not show any toxic effects. Therefore, the study suggests that SCEs are safe and have potent immunostimulatory activity and hence, seems to be a promising balanced @entity9 and Th2 directing immunological adjuvant for various veterinary as well as @entity0 vaccines.

title: Augmentation of humoral and cellular immunity in response to @entity2 and @entity12 toxoids by supercritical XXXX extracts of Hippophae rhamnoides L. leaves.

answer: @entity6


abstract: Bacterial profile modification is an important enhanced oil recovery technique used to direct injected water into a reservoir's low permeability zone containing trapped crude oil. During water flooding, the use of bacteria to plug the high permeability water zone and divert flow into the oil-bearing low-permeability zone will have a significant economic impact. However, during the field implementation of bacterial profile modification, the rapid growth of bacteria near the injection well bore may hinder the subsequent injection of growth media so that profile modification of the reservoir occurs only in the immediate vicinity of the well bore. By slowing the growth rate and prolonging the lag phase, the onset of pore-space plugging may be delayed and the biologically active zone extended deep into the reservoir. High substrate loading, high pH values, and the addition of the growth inhibitors @entity1 and @entity2 have been used in combination to alter the growth characteristics of @entity3 NRRL-B523 grown in batch conditions. The highest @entity0 concentration used in these studies, 500 g/L, produced lag times 12-fold greater than the slowest lag times achieved at low @entity0 concentrations. When @entity3 was grown in media containing 500 g/L @entity0 , an alkaline pH value threshold was found above which bacteria did not grow. At this threshold pH value of 8.1, an average lag time of 200 h was observed. Increasing the concentration of @entity2 had no effect on lag time, but reduced the growth rate until the threshold concentration of 0.6%, above which bacteria did not grow. Last, it was found that a solution of 0.075 mM @entity1 in media containing 15 g/L @entity0 completely inhibited bacterial growth.

title: Alteration of the growth rate and lag time of XXXX NRRL-B523.

answer: @entity3


abstract: BACKGROUND: Percutaneous endoscopic gastrostomy ( @entity3 ) is offered to @entity2 ( @entity2 ) @entity0 with severe @entity4 . Immediate benefits of @entity3 are adequate food intake and weight stabilization. However, the impact of @entity3 on survival is still uncertain. In this work we retrospectively evaluated the effect of @entity3 on survival in a cohort of @entity2 @entity0 followed in a tertiary referral centre. METHODS: Between 2000 and 2007, 150 dysphagic @entity2 @entity0 were followed until @entity1 or tracheostomy. @entity3 was placed in 76 @entity0 who accepted the procedure and survival was analysed using the Kaplan-Meier life-table method. RESULTS: In @entity2 @entity0 submitted to @entity3 , no major complications were observed. Total median survival time from symptom onset was 38 months for @entity3 users as compared to 32 months for the remaining dysphagic @entity0 who declined the procedure (p=0.05). Among bulbar-onset @entity0 , @entity3 users showed a median survival time longer than those with no @entity3 (28 months vs. 25 months), even though the difference was not significant. Conversely, dysphagic spinal-onset @entity0 with @entity3 lived significantly longer than those who refused this palliative care (44 months vs. 36 months, p=0.046). Survival in @entity0 with @entity3 was not affected by the severity of the @entity5 , as measured by forced vital capacity. CONCLUSIONS: This study demonstrates that @entity3 improves survival in dysphagic @entity2 @entity0 , with few side effects. The procedure is safe and applicable even to @entity0 with impaired respiratory function. @entity3 remains a milestone in palliative care in dysphagic @entity2 @entity0 .

title: Percutaneous endoscopic gastrostomy in XXXX : effect on survival.

answer: @entity2


abstract: @entity4 ( @entity4 ) has been associated with a marked @entity1 , especially short-term after injury. The absence of mechanical load, mediated by osteocyte mechanosensory function, seems to be a causative factor related to @entity3 in this condition. However, the pathogenesis and clinical management of this process remain unclear. Therefore, the aim of the study was to analyze the effect of recent @entity4 on the Wnt pathway antagonists, sclerostin and @entity5 ( @entity5 ), and their relationship with bone turnover and @entity1 ( @entity1 ) evolution. Forty-two @entity0 (aged 35        14yrs) with a recent (<6months) complete @entity4 were prospectively included. Sclerostin and @entity5 , bone turnover markers (bone formation: PINP, bone ALP; resorption: sCTx) and @entity1 (lumbar spine, proximal femur, total body and lower extremities [DXA]) were assessed at baseline and at 6 and 12 months. The results were compared with a healthy control group. 22/42 @entity0 completed the 12-month follow-up. At baseline, @entity4 @entity0 showed a marked increase in bone markers (PINP and sCTx), remaining significantly increased at up to 6 months of follow-up. Additionally, they presented significantly increased @entity5 values throughout the study, whereas sclerostin values did not significantly change. @entity1 markedly decreased at the proximal femur (-20.2        5.4%, p   <   0.01), total body (-5.7        2.2%, p   =   0.02) and lower extremities (-13.1        4.5%, p   =   0.01) at 12 months. Consequently, 59% of @entity0 developed densitometric @entity2 at 12 months. @entity0 with higher @entity5 values (>58   pmol/L) at baseline showed higher sublesional @entity1 loss. In conclusion, this study shows that short-term after @entity4 there is a marked @entity1 and @entity3 , the latter associated with an increase in @entity5 serum levels. The persistence of increased levels of this Wnt antagonist throughout the study and their relationship with the magnitude of @entity3 suggests a contributory role of this mediator in this process.

title: Effect of recent XXXX on wnt signaling antagonists (sclerostin and @entity5 ) and their relationship with @entity3 . A 12-month prospective study.

answer: @entity4


abstract: UNASSIGNED: Distant metastases arise in 20-30% of @entity0 with @entity5 of the @entity3 ( @entity4 ) in the 2 years following treatment. Therapeutic options are limited and the outcome of the @entity0 is poor. The identification of predictive biomarkers of @entity0 at risk for distant @entity1 and therapies are urgently needed. We previously identified a clinical subgroup, called @entity7 " characterized by high propensity for rapid distant @entity1 . Here, we showed that @entity7 " @entity0 do not or at very low level express @entity8 ( @entity8 ). Low or no expression of @entity8 is of bad prognosis. Disappearance of @entity8 enables cells to undergo epithelial-mesenchymal transition (EMT). EMT is associated with enhanced @entity6 and invasion. Our study uncovered a new target, a5b1 integrin. Targeting a5b1 integrins might not only prevent @entity1 of @entity4 but also delay the development of the @entity2 by reducing @entity2 cell viability. @entity8 detection might be taken into consideration in the future in the clinic not only to identify @entity0 at high risk of @entity1 but also to select @entity0 who might benefit from an anti-integrin therapy.

title: XXXX -negative @entity4 primary @entity2 display increased epithelial to mesenchymal transition and prometastatic properties.

answer: @entity8


abstract: Experiments were performed on unanesthetized @entity0 (n=6) to determine the systemic hemodynamics during chemoreflex activation by intravenous KCN. @entity0 chronically instrumented with ultrasonic flow probes in the ascendant aorta were submitted to KCN injections (30 microg/kg) before and after sequential administration of the autonomic blockers @entity4 and @entity3 . In the control period KCN injections produced a 60% reduction in heart rate (HR) and a 46% elevation in blood pressure (BP), while cardiac output (CO) decreased 76%, @entity1 volume (SV) decreased 40%, and calculated total peripheral resistance (TPR) increased 900%. @entity4 administration increased resting HR, whereas no change was observed in CO or BP. Chemoreflex-induced @entity2 was markedly attenuated (26%), and the pressor response was potentiated (59%) after @entity4 administration. CO and TPR responses were both attenuated after @entity4 administration (68% and 718%, respectively). Sequential administration of @entity3 decreased HR but did not change the cardiovascular responses to KCN injections compared with the responses observed after @entity4 administration. In conclusion, CO is greatly reduced during KCN-evoked chemoreflex. Besides the intense @entity2 , a decrease in SV contributed to this reduction. Bradycardic response was most dependent on the cardiac parasympathetic activation, and the reduction in SV was probably most dependent on the increased cardiac afterload due to the sudden increase in BP.

title: Hemodynamics of chemoreflex activation in unanesthetized XXXX .

answer: @entity0


abstract: PURPOSE: To detect cell specific apoptosis factors, Fas and @entity1 , and the common intracellular apoptosis modulators, @entity8 (ICE)-like protease ( @entity8 ), @entity4 , @entity6 and @entity5 in lens epithelial cells (LEC) of @entity0 @entity2 . To study the effects of Fas-stimulating monoclonal antibody on inhibition of LEC proliferation. METHODS: Reverse-transcriptase-polymerase chain reaction (RT-PCR) was used to detect Fas, @entity1 , @entity8 , @entity4 , @entity6 and @entity5 , after cDNA was synthesized from the total RNA isolated from @entity0 @entity2 LEC obtained by capsulotomy during @entity2 surgery. Fas-stimulating monoclonal antibody was added at the concentrations of 10, 30, 100, 300 and 1000 ng/ml to the incubation medium of @entity0 @entity2 LEC; and the specimens were incubated for 24 h at 37 degrees C with 5% @entity3 circulation and 100% humidity. The specimens were then stained with @entity7 , and the number of apoptotic cells was counted. RESULTS: Fas, @entity8 , @entity4 , @entity6 and @entity5 mRNA were detected by RT-PCR. @entity1 mRNA was not detected by RT-PCR. At each concentration, Fas-stimulating monoclonal antibody significantly inhibited LEC proliferation. CONCLUSIONS: @entity0 @entity2 LEC expressed mRNA of Fas and various modulators of apoptosis pathways. Fas-stimulating monoclonal antibody may have the potential to prevent posterior capsule opacification after @entity2 surgery by inhibiting LEC proliferation.

title: Inhibition of lens epithelial cells by Fas-specific antibody activating Fas- XXXX system.

answer: @entity1


abstract: PURPOSE: The aim of the study was to estimate interfractional deviations in @entity0 and prostate position, the impact of the frequency of online verification on the treatment margins, and to assess acute radiation reactions of high-dose external beam image-guided intensity-modulated radiotherapy (IG-IMRT) of @entity2 . @entity0 AND METHODS: IG-IMRT was performed by daily online verification of implanted fiducial prostate markers using a megavoltage electronic portal imaging device (EPID). A total of 1011  image-guided treatment fractions from 23  consecutive unselected @entity2 @entity0 were analyzed. The median total dose was 79.2  Gy (range 77.4-81.0  Gy). Acute radiation reactions were assessed weekly during radiotherapy using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.03. RESULTS: A relevant combined @entity0 set-up and prostate motion population random error of 4-5  mm was observed. Compared to daily IGRT, image guidance every other day required an expansion of the CTV- @entity3 (clinical target volume-planning target volume) margin of 8.1, 6.6, and 4.1  mm in the longitudinal, vertical, and lateral directions, thereby, increasing the @entity3 by approximately 30-40   %. No grade 3 or 4 acute radiation reactions were observed with daily IG-IMRT. CONCLUSION: A high dose with surprisingly low acute @entity1 can be applied with daily IG-IMRT using implanted fiducial prostate markers. Daily image guidance is clearly superior to image guidance every other fraction concerning adequate target coverage with minimal margins.

title: Image-guided intensity-modulated radiotherapy of @entity2 : Analysis of interfractional errors and acute XXXX .

answer: @entity1


abstract: STATEMENT OF PROBLEM: To my knowledge, there is no systematic review of crestal @entity2 (CBL) around submerged and nonsubmerged dental implants. PURPOSE: The purpose of this review was to systematically assess CBL around submerged and nonsubmerged dental implants. MATERIAL AND METHODS: The addressed focused question was, "Does crestal and subcrestal placement of dental implants influence crestal bone levels?" Databases were searched from 1986 through October 2015 using different combinations of the following keywords: crestal, sub-crestal, @entity2 , dental implant, submerged, and nonsubmerged. Reference lists of potentially relevant original and review articles were hand-searched to identify any further studies. Letters to the editor, case reports, commentaries, studies on platform-switched implants, and studies published in languages other than English were excluded. RESULTS: In total, 13 studies (6 @entity0 and 7 animal), which were performed at universities, were included. In the @entity0 studies, the number of @entity0 ranged from 8 to 84 individuals. The follow-up period ranged from 1 to 5 years. CBL at the test sites ranged from 0.17 mm to 0.9 mm and at control sites from 0.02 mm to 1.4 mm. Five @entity0 studies reported no significant difference in CBL around implants placed at the test and control sites. All animal studies were performed in @entity1 with a mean age ranging from 1 to approximately 2 years. The follow-up period ranged from 2 to 6 months. Four animal studies reported no significant difference in CBL around submerged and nonsubmerged implants. CONCLUSION: No significant difference in CBL was found around submerged and nonsubmerged dental implants.

title: Crestal XXXX around submerged and nonsubmerged dental implants: A systematic review.

answer: @entity2


abstract: It is well known from behavioural experiments that @entity0 with @entity2 ( @entity2 ) have difficulties discriminating consonant-vowel (CV) syllables such as /ba/, /da/, and /ga/. @entity1 ( @entity1 ) is an auditory event-related potential component that represents the outcome of an automatic comparison process. It could, therefore, be a promising tool for assessing central auditory processing deficits for speech and non-speech stimuli in @entity0 with @entity2 . @entity1 is typically evoked by occasionally occurring 'deviant' stimuli in a sequence of identical 'standard' sounds. In this study @entity1 was elicited using simple tone stimuli, which differed in frequency (1000 versus 1200 Hz) and duration (175 versus 100 ms) and to digitized CV syllables which differed in place of articulation (/ba/, /da/, and /ga/) in @entity0 with expressive and receptive @entity2 and healthy control @entity0 (n=21 in each group, 46 males and 17 females; age range 5 to 10 years). Mean @entity1 amplitudes between groups were compared. Additionally, the behavioural discrimination performance was assessed. @entity0 with @entity2 had attenuated @entity1 amplitudes to speech stimuli, but there was no significant difference between the two diagnostic subgroups. @entity1 to tone stimuli did not differ between the groups. @entity0 with @entity2 made more errors in the discrimination task, but discrimination scores did not correlate with @entity1 amplitudes. The present data suggest that @entity0 with @entity2 show a specific deficit in automatic discrimination of CV syllables differing in place of articulation, whereas the processing of simple tone differences seems to be unimpaired.

title: Automatic processing of tones and speech stimuli in @entity0 with XXXX .

answer: @entity2


abstract: UNASSIGNED: Parenteral antibiotic prophylaxis is the current standard of therapy in clean-contaminated @entity1 surgery. Nevertheless, the incidence of @entity2 ( @entity2 ) in oral oncological surgery is relatively high, especially in major surgery with reconstruction and tracheotomy. The aims of this study were to investigate the perioperative condition related to microorganisms in the oral cavity and to examine the efficacy of the topical administration of @entity3 in reducing the number of bacteria in the oropharyngeal fluid during intubation. The number of oral bacteria was measured during intubation in @entity0 undergoing major @entity1 surgery. The efficacy of the topical administration of @entity3 or @entity4 gel in reducing the bacteria was then investigated. Bacteria in the oropharyngeal fluid grew from 10(6)CFU/ml to 10(8)CFU/ml during the 3h after intubation (CFU, colony-forming units). When @entity3 was applied to the dorsum of the tongue, oral bacteria decreased immediately to 10(5)CFU/ml, and the number of bacteria in the oropharyngeal fluid was maintained below 10(7)CFU/ml for 7h. The concentration of @entity3 in the oropharyngeal fluid was extremely high for several hours after topical administration. The topical administration of @entity3 could reduce oral bacteria in @entity0 undergoing clean-contaminated @entity1 surgery. This method is expected to be effective in the prevention of @entity2 .

title: Efficacy of topical antibiotic administration on the inhibition of perioperative oral bacterial growth in XXXX @entity0 : a preliminary study.

answer: @entity1


abstract: UNASSIGNED: 2062 Background: Treatment of @entity1 ( @entity18 ) remains challenging due to advanced @entity6 at presentation and limited treatment options. METHODS: All @entity0 underwent standard pre-treatment @entity18 assessment including @entity16 assessment (cytology or flow cytometry), brain and spine MR imaging, and radioisotope @entity16 flow study. Liposomal @entity15 was administered intraventricularly (n=80) or intralumbar (n=40) at 50mg every 2-weeks x4 and then every 4-weeks x6 in responding @entity0 . @entity10 (4mg orally twice per day x5days) was co-administered with each liposomal @entity15 treatment. @entity0 were seen with each liposomal @entity15 treatment and assessed for @entity5 . RESULTS: 120 adult @entity0 (median age 51 years [range 33-68]) with @entity18 were treated with liposomal @entity15 . Liposomal @entity15 Common @entity5 Criteria > Grade 3 @entity14 was seen in 62 cycles (11.9%) in 28 @entity0 (23.3%). @entity5 included @entity17 (3.75% ventricular: 0% lumbar); @entity11 (17.5%:15%); communicating @entity12 (3.75%: 5%); conus medullaris/ @entity13 (5%:5%); decreased visual acuity (5%:2.5%); @entity4 (5%: 5%); @entity3 (7.5%: 2.5%); @entity8 (2.5%: 2.5%); @entity9 (1.25%: 5%); and @entity7 (1.25%: 2.5%). Distribution of @entity5 was similar regardless of route of administration (ventricular vs. lumbar). @entity5 were transient in 38 episodes (61.3%) and permanent in 24 (38.7%; 17 @entity0 ). There were no treatment-related deaths however 20 treatment-related @entity5 (32.2%) required hospitalization. CONCLUSIONS: Liposomal @entity15 is mostly well tolerated however a subset of @entity0 (14%) not easily identified pre-treatment develop serious treatment-related @entity2 that may be persistent and impact quality of life.

title: @entity14 of intra- @entity16 liposomal XXXX in the treatment of leptomeningeal metastases.

answer: @entity15


abstract: The incidence of @entity4 ( @entity4 ) has been rapidly increasing in epidemic proportions all over the world. The purpose was to evaluate the demographic and clinico-pathological patterns of @entity4 in Izmir, a region with high ultraviolet light exposure. The study was retrospective and hospital-based. The data related to all NMSC @entity0 registered from January 1, 1990, to December 31, 1999, in the Dermatology Department of Ege University Medical School in Izmir, were collected and analyzed according to the personal statistics, anatomic location, dimensions of the lesion and clinical and @entity4 . A total number of 2,879 @entity0 , aged between 20 and 96 years, were included in the study; among them 1,633 were @entity0 and 1,246 were @entity0 . The mean age of the @entity0 population was 62.81 years, with a standard deviation of 12.50 years. Among the @entity1 @entity0 , there were 2,062 @entity5 ( @entity5 ), 746 @entity3 ( @entity3 ) and 71 both BCC and SCC; the total number of lesions was 3,186 (2,339 @entity5 , 847 @entity3 ). Of all the NMSC lesions studied, the highest percentage (46.6%) were located on the face. For the @entity5 , the most frequent histopathological subtype was the solid pattern (50.74%). The mean male: female ratios for SCC and @entity2 were 2.86 and 1.01, respectively. Nodular and ulcerative forms (69.8%) were the most commonly found clinical types. Of all @entity4 , 78.4% had diameters in the 11 to 20 mm. BCC is the most common type of @entity4 diagnosed in our region. Among the NMSC @entity0 , farming was the most widespread and risky job. The majority of SCC @entity1 were observed mostly in @entity0 60 years old or above. This is the first comprehensive description of @entity4 in our region.

title: XXXX between the years of 1990 and 1999 in Izmir, Turkey: demographic and clinicopathological characteristics.

answer: @entity4


abstract: AIM: The authors analyzed in a retrospective manner the prognostic significance of @entity2 and @entity5 expression, DNA ploidy, S-phase fraction (SPF), and traditional clinical and pathological prognostic factors in @entity0 with uterine @entity4 . MATERIAL: Forty-nine @entity0 were diagnosed with @entity4 (25 stage I, 4 stage II, 8 stage III, and 12 stage IV). DNA flow cytometric analysis and immunohistochemical staining for @entity2 and @entity5 were performed on @entity3 -embedded archival tissue from the uterine @entity1 . RESULTS: Of the 49 @entity0 , 35 (71%) died of disease and 2 died of intercurrent disease. The 5-year survival rate was 33%. FIGO surgical stage, DNA ploidy, SPF, mitotic index, cellular atypia, and @entity1 grade obtained significance (P < 0.05) in a univariate survival analysis of the @entity4 . In a multivariate analysis with survival as the end point, stage was found to be the most important factor (P = 0.007); DNA ploidy (P = 0. 045) and SPF (P = 0.041) also had independent prognostic significance. For FIGO stage I @entity1 , DNA ploidy (P = 0.04) and @entity1 grade (P = 0.01) were statistically significant in a univariate analysis, while only grade had independent prognostic significance (P = 0.01) in a multivariate analysis. In a univariate analysis including only FIGO stage I and II @entity1 with disease-free survival as the end point, @entity2 overexpression (P = 0.0016), DNA ploidy (P = 0.042), and @entity1 grade (P = 0.008) obtained significance. In a multivariate analysis, only @entity2 had independent statistical significance (P = 0.01). All @entity2 immunopositive stage I-II @entity1 recurred within 28 months from diagnosis. CONCLUSION: This study found that stage represents the most important prognostic factor for uterine @entity4 . DNA ploidy and SPF had independent prognostic value. DNA flow cytometry is useful in gaining additional prognostic information. In stage I @entity0 , @entity1 grade gives significant information regarding clinical outcome. In addition, @entity2 overexpression may predict a higher risk of recurrence in early stage @entity4 .

title: @entity4 : A clinicopathologic, DNA flow cytometric, XXXX , and @entity5 analysis of 49 cases.

answer: @entity2


abstract: UNASSIGNED: Vaginal reconstruction after @entity4 ( @entity4 ) represents a challenge for the oncologic surgeon. Since the introduction of perforator flaps, using pedicled vertical DIEP (deep inferior epigastric perforator) flap allows to reduce the donor site complication rate. From November 2012 to December 2014, 27 PEs were performed in our institution. 13 @entity0 who underwent @entity4 with vaginal reconstruction and programmed DIEP procedure for gynecologic @entity1 were registered. Nine @entity0 underwent @entity4 for recurrent disease and four for primary treatment. Six of the 13 @entity0 have a preoperative @entity3 . Anterior @entity4 was performed in 10 @entity0 , and total @entity4 in 3 @entity0 . A vertical DIEP flap was performed in 10 @entity0 using one or two medial perforators. The reasons for abortion of vertical DIEP flap procedure were: failure to localizing perforator vessels in two cases, and unavailability of plastic surgeon in one case. A vertical fascia-sparring rectus abdominis myocutaneous flap was then harvested. Median length of surgery was 335min, and 60min for DIEP harvesting and vaginal reconstruction. No flap @entity2 occurred. One @entity0 in the VRAM (vertical rectus abdominis myocutaneous) group experienced a late incisional @entity5 and one @entity0 in the DIEP flap group required revision for vaginal @entity6 . In our experience, DIEP flap represents our preferred choice of flap for circumferential vaginal reconstruction after @entity4 . To achieve a high reproducibility, the technically demanding pedicled vertical DIEP flap has to be harvested by a trained surgeon, after strict evaluation of the preoperative imaging with identification and localization of perforator vessels.

title: Vaginal reconstruction with pedicled vertical deep inferior epigastric perforator flap (diep) after XXXX . A consecutive case series.

answer: @entity4


abstract: The action of @entity5 ( @entity5 ) on @entity0 signalling in HeLa cells and cardiac myocytes was investigated. Consistent with other studies, we found that superfusion of cells with @entity5 rapidly inhibited @entity2 (InsP(3))-mediated @entity0 release and store-operated @entity0 entry (SOC). In addition to abrogating hormone-evoked @entity0 responses, @entity5 could antagonise @entity0 signals evoked by a membrane permeant InsP(3) @entity4 . @entity5 also slowed the recovery of intracellular @entity0 signals consistent with an effect on @entity0 ATPases. The inhibitory action of @entity5 on InsP(3) receptors (InsP(3)Rs), SOC channels and @entity0 pumps persisted for several minutes after washout of the compound. Application of @entity5 to unstimulated cells had no effect on subsequent @entity0 responses suggesting that it has a use-dependent action. Mitochondria in cells treated with @entity5 showed a rapid and slowly reversible swelling. @entity5 did not cause the mitochondria to depolarise, but it reduced the extent of mitochondrial @entity1 uptake. Although @entity5 has been demonstrated not to affect voltage-operated @entity0 channels or @entity3 receptors, we found that it gave a concentration-dependent long-lasting inhibition of @entity0 signalling in electrically-stimulated cardiac myocytes, where InsP(3)Rs and SOC channels do not play a significant role. Our data suggest that @entity5 has multiple cellular targets, a use-dependent action, is difficult to reverse and may affect @entity0 signalling in cell types where InsP(3) and SOC are not active.

title: @entity5 ( XXXX ) antagonises @entity2 -induced @entity1 release, inhibits @entity1 pumps and has a use-dependent and slowly reversible action on store-operated @entity1 entry channels.

answer: @entity5


abstract: UNASSIGNED: Two Croatian siblings with atypical clinical findings in the presence of @entity8 gene mutations are reported. The @entity0 presented with delayed motor development and @entity3 in hands and feet in her first year of life. She never stood or walked and developed @entity5 and @entity4 during childhood. Her hands and feet were non-functional when last seen at age 14 years. Her 4-year-old brother was more severely affected and had a clinical picture resembling @entity7 ( @entity6 ) type 1. He also showed unusual distally pronounced @entity3 and @entity3 . Both @entity0 had no sensory deficits but gave evidence of a mixed @entity2 with pronounced slowing in the distal nerve segments. Unexpectedly, both siblings showed a compound heterozygous @entity8 mutation (heterozygous deletion and missense mutation @entity10 ; @entity11 ), thus confirming @entity7 . In addition, next generation sequencing of 52 genes for @entity1 revealed a heterozygous missense mutation @entity12 ; @entity13 in the @entity9 gene that was transmitted by the healthy father. Our observations widen the phenotypic consequences of @entity8 gene mutations and support the notion to look for additional genetic factors which may modify the clinical picture in atypical cases.

title: Distally pronounced @entity7 with severe @entity2 associated with the XXXX mutation of @entity8 .

answer: @entity11


abstract: OBJECTIVE: The purpose of the study was to assess the frequency of dental @entity2 and/or fear among @entity0 in an emergency dental service. METHODS: Research was based on interviews with 252 @entity0 , aged 18 years old and over, attended at an emergency dentistry service of S  o Paulo, Brazil, from August to November, 2001. Two methods were used to measure dental @entity2 : the Modified Dental @entity2 Scale (MDAS) and the Gatchel Fear Scale. The study group answered questions concerning major complaint, how much time had elapsed since their last visit to the dentist and since the initial symptoms leading to the current visit to the emergency service, level of education, family income and previous @entity1 . Statistical analysis (chi2 and Fisher exact test) was performed to evaluate these characteristics. RESULTS: It was found that 28.17% of this sample was dentally anxious, according to the MDAS, and 14.29%, felt fear related to dental treatment according to the Gatchel Fear Scale. @entity0 were more anxious than @entity0 at a statistically significant rate (MDAS). The time elapsed since the onset of initial symptoms was more than 7 days for 44.44% of the @entity0 . A large proportion of anxious @entity0 returned to treatment during the last year. A previous traumatic experience with dental was identified in 46.48% of the dentally anxious @entity0 . No significant relation between level of education or income and dental @entity2 was found. CONCLUSIONS: Dentally anxious @entity0 frequent attend emergency care. Females are more likely to report high dental @entity2 than males. Previous experience seems to be an important factor contributing to avoidance of dental care.

title: [Dental XXXX in an emergency dental service].

answer: @entity2


abstract: BACKGROUND: Ring chromosomes are normally associated with @entity2 and are rarely inherited. An exception to this rule is provided by deletion/ring cases. We were provided with a unique opportunity to investigate the meiotic segregation at oogenesis in a @entity0 who is a carrier of a deleted/ring 22 chromosome. The couple requested preimplantation genetic diagnosis (PGD) following the birth of a son with a mosaic karyotype.The couple underwent two cycles of PGD. Studies were performed on lymphocytes, single embryonic cells removed from 3 day-old embryos and un-transferred embryos. Analysis was carried out using fluorescence in situ hybridisation (FISH) with specific probe sets in two rounds of hybridization. RESULTS: In total, 12 embryos were biopsied, and follow up information was obtained for 10 embryos. No embryos were completely normal or balanced for chromosome 22 by day 5. There was only one embryo diagnosed as balanced of 12 biopsied but that accumulated postzygotic errors by day 5. Three oocytes apparently had a balanced chromosome 22 complement but all had the deleted and the ring 22 and not the intact chromosome 22. After fertilisation all the embryos accumulated postzygotic errors for chromosome 22. CONCLUSION: The study of the preimplantation embryos in this case provided a rare and significant chance to study and understand the phenomena associated with this unusual type of @entity1 during @entity4 and in the earliest stages of development. It is the first reported PGD attempt for a @entity3 .

title: Meiotic and mitotic behaviour of a ring/deleted chromosome 22 in XXXX embryos determined by preimplantation genetic diagnosis for a maternal carrier.

answer: @entity0


abstract: BACKGROUND: Obesity has been correlated with various adverse events in @entity0 who receive left ventricular assist devices (LVAD). In this study, we sought to further characterize the role of @entity2 in this @entity0 population.Methods   and   Results:We performed a retrospective analysis of 164 @entity0 implanted with a HeartMate II from August 2008 to December 2014. @entity0 were categorized into 2 BMI groups based on WHO guidelines: BMI 18.5-30 kg/m(2)(n=99) and BMI >30 kg/m(2)(n=65). @entity0 demographics, adverse outcome and long-term survival were compared between the 2 groups. For any outcome associated with BMI groups, we performed a Cox regression to identify confounding comorbidities. Preoperative demographics and comorbidities were similar. @entity0 with BMI >30 were younger (P=0.01) and had a higher incidence of @entity4 2 @entity1 (P=0.01). While rate of pump @entity5 was higher among @entity0 with BMI >30 (P=0.02), overall survival at 2 years did not differ. The most common cause of death was @entity3 in the @entity2 group. On multivariable cox regression analysis, BMI was an independent risk factor of pump @entity5 . CONCLUSIONS: Higher BMI does not reduce survival after VAD implantation but it does appear to increase the risk of pump @entity5 . Further studies to characterize the role of BMI in survival and @entity5 rates are warranted.

title: Higher Body Mass Index Increases Risk of HeartMate II Pump XXXX But Does Not Adversely Affect Long-Term Survival.

answer: @entity5


abstract: BACKGROUND: The aim of the present study was to analyse serial position effects for immediate and delayed free recall in @entity0 with @entity1 of the Alzheimer type and controls. EXPERIMENT 1: 44 @entity0 with @entity1 of the Alzheimer-type and 24 non-demented controls were asked for immediate and delayed free recall of 12 schematic drawings of common objects presented at the rate of 10 s/picture. Steep primacy effects were obtained at all delays in controls. By contrast, primacy effects were significantly impaired in @entity0 with @entity1 at all delays of recall. Small immediate and delayed recall recency effects were found in both, @entity0 and controls. EXPERIMENT 2: 19 @entity0 with @entity1 of the Alzheimer type and 21 controls were asked for immediate and delayed free picture recall with presentation rates of 10, 5 and 1 s/picture. Again, primacy effects were significantly impaired in demented @entity0 versus controls. With shorter presentation times, immediate recall recency effects were more pronounced than with longer presentation times, and no delayed recall recency effects were found. CONCLUSIONS: Primacy effect is impaired for immediate and delayed recall in @entity1 of the Alzheimer type. By contrast, immediate recall recency effect and possibly also long-term recency effect are preserved. The loss of the primacy effect contributes to the @entity2 in @entity1 of the Alzheimer type. Therefore further research is warranted into pharmacological and psychological interventions that might re-establish the primacy effect. Possibly, the orientation of demented @entity0 might be improved by psychological techniques that rely on long-term recency effect.

title: Serial position effects in XXXX of the Alzheimer type.

answer: @entity1


abstract: BACKGROUND:: There are limited studies investigating the relationship between oral release osmotic system- @entity5 (OROS-MPH) doses and plasma @entity5 ( @entity8 ) concentrations in @entity0 and adolescents. The aim of the present study was to investigate the relationship between the doses of OROS- @entity8 and the plasma levels of the drug. We also examined the effects of the other drugs including @entity4 , @entity3 , @entity2 , and @entity6 on the levels of the @entity8 in the plasma. METHODS:: The files of 100 @entity1 subjects (76 male, 24 female) who were diagnosed as @entity1 according to the DSM-IV criteria, were screened. The ages of subjects were between 6-18 years (mean= 11.5  3.8 years). Plasma @entity8 levels were determined by @entity7 ( @entity7 ). RESULTS:: Daily mean OROS @entity8 dose used in @entity1 @entity0 was 0.7  0.2 mg/kg (range: 0.3-1.3 mg/kg). The mean plasma OROS @entity8 was 11.6    7.3 ng/mL (range: 0.5-43.4 ng/mL). There was no group difference in the mean plasma @entity8 and dose-related @entity8 levels between the groups that used any additional drug including @entity4 (n=25), @entity3 (n=10), @entity2 (n=16) @entity6 (n=10) and not used these drugs (p>.05). There was a positive correlation between the OROS @entity8 doses (mg/kg) and the blood @entity8 levels (Pearson correlation= 0.40; p<.001). The plasma levels of @entity8 were found to be less than 13 ng/mL in 65% of the subjects. CONCLUSIONS:: Our findings point to the fact that plasma levels of @entity8 show a wide range of changes at similar doses, correlate positively with the doses and, as expected, are not affected by using @entity3 , @entity6 , @entity2 , and @entity4 . Therapeutic drug monitoring (TDM) may help to optimize @entity8 dose in @entity0 not responding to treatment or in those experiencing serious side effects, but not in routine clinical practice. The presence of intermediate dose formulations such as 45 mg tablets for OROS @entity8 may contribute to the optimization.

title: Plasma XXXX Levels In Youths with Attention @entity1 Treated with OROS Formulation.

answer: @entity5


abstract: PURPOSE: To compare exercise capacity and cardiovascular response to exercise in elderly individuals with @entity2 ( @entity2 ) who attend ongoing community-based maintenance cardiac rehabilitation (CR) versus age- and gender-matched healthy "very active" ( @entity3 ;   >=    2000   kcal/week) and healthy "less active" (HLA; <2000   kcal/week) individuals. METHOD: Sixty-three @entity0 (age: 72.3        5.1 years; 62% @entity0 ; n   =   21 per group) completed the following assessments: (1) symptom-limited graded exercise test with expired gas analysis and bioimpedance assessment of cardiovascular function during exercise; (2) walking tests; (3) physical function; (4) anthropometry and (5) 12-month physical activity recall. RESULTS: The CR group achieved 98% (range: 73-154%) of age- and gender-predicted peak @entity1 consumption for healthy individuals. Peak @entity1 consumption was lower in CR compared to @entity3 but not HLA group (VO2peak: CR: 19.0        4.5, @entity3 : 23.7        2.9, HLA: 20.7        4.7   ml   kg(-1)  min(-1), p   =   0.001 versus @entity3 ; p   =   0.390 versus HLA). Peak heart rate was lower in CR compared to both @entity3 and HLA. Walking test results and cardiovascular and physical function were not different between the groups. CONCLUSIONS: Elderly individuals with @entity2 participating in maintenance CR have similar exercise capacity and cardiorespiratory response to exercise compared to their age- and gender-matched less active healthy peers. The findings support referral of elderly @entity0 to community-based CR. Implications for Rehabilitation Fitness benefits of long-term maintenance cardiac rehabilitation (CR) programs remain unknown. Elderly individuals with @entity2 participating in maintenance CR have exercise capacity and cardiorespiratory response to exercise similar to their less active healthy peers. Maintenance CR may play an important role prolonging independent living in elderly individuals.

title: Long-term effects of cardiac rehabilitation in elderly individuals with stable XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine the value of radiological features in the diagnosis of @entity2 ( @entity2 ). STUDY DESIGN: Retrospective review of the radiological materials of 65 @entity0 with documented @entity2 treated at the same institution. METHODS: Evaluation by the ENT surgeon and the head and neck radiologist. RESULTS: @entity2 was more common in female @entity0 in this series. Fifty-four (83%) @entity0 were above 30 years of age, with a peak of 18 @entity0 (27.7%) in the seventh decade. All the @entity0 except one (98.5%) showed bilateral mucosal thickening on unenhanced CT scans. Thirty-eight @entity0 (58%) showed increased intrasinus attenuation on unenhanced CT scans. Thirty-seven @entity0 (57%) showed opacification of at least one sinus; 25 (38%) showed @entity3 ; 11 (17%) had erosion of the sinus wall and only one @entity0 showed minor expansion of an involved sinus. In 6 @entity0 , typical hyperattenuation patterns on CT scans, together with distinctive MRI images, were highly suggestive of @entity2 . CONCLUSION: Our data show that hyperattenuation on CT images with bone window settings suggests the presence of @entity2 . This hyperattenuation is more clearly seen with soft-tissue window settings. When necessary, adjunctive MRI can provide information which might be highly predictive for the diagnosis of @entity2 . However, non-specific imaging findings of @entity1 ( @entity1 ) should also be seen as possible @entity2 pathology.

title: XXXX ( @entity2 ): a distinct CT/MRI-entity? A European experience.

answer: @entity2


abstract: Increased levels of second trimester maternal serum @entity1 (MSAFP) have long been established as a marker for @entity2 ( @entity2 ). In addition, decreased levels of maternal @entity5 in the third trimester have been reported in pregnancies with anencephalic fetuses. The purpose of this study was to evaluate whether early second trimester unconjugated serum @entity5 (uE3) is an independent predictor of @entity2 . The study included 57,031 @entity0 who underwent maternal serum screening with MSAFP at 14-22 weeks gestation. Of these, 23,415 also had uE3 measurements. There were 63 cases of @entity3 , an overall incidence of 1.1 per 1,000. Elevated MSAFP (> or =2.5 MOM) was detected in 1,346 @entity0 , 48 of which had @entity2 . Decreased uE3 (< or =0.5) was detected in 1,437 @entity0 , 17 of which had @entity2 . The incidence of @entity2 was significantly higher in @entity0 with low uE3, compared to @entity0 with normal/high uE3 (1.15% vs. 0.09%, P < 001). Finally, 51 @entity0 had both increased MSAFP and decreased uE3; 16 of these had @entity2 , 14 of which were anencephalics. In conclusion, both elevated MSAFP and low maternal serum @entity5 are predictive of @entity3 but have a low sensitivity. The combination of abnormally elevated MSAFP and low @entity5 is highly predictive of @entity3 in particular @entity4 .

title: Combination of elevated maternal serum @entity1 (MSAFP) and low @entity5 is highly predictive of XXXX .

answer: @entity4


abstract: To examine the role of the fibrinolytic system in @entity3 -induced @entity5 , we compared the effect of a chronic @entity3 challenge in plasminogen activator inhibitor-deficient (C57BL/6JPAI-1-/-) @entity0 and @entity2 ( @entity2 ) C57BL/6J @entity0 . Physiological and biological assessments were performed, immediately after, and 4 wk after an 8-wk exposure to @entity3 or saline. Immediately after the @entity3 exposure, @entity2 @entity0 had increased estimates of airway reactivity to @entity8 compared with C57BL/6JPAI-1-/- @entity0 ; however, @entity1 was similar in both @entity3 -exposed groups. Significant increases in both active @entity4 and active @entity7 was detected after @entity3 exposure in @entity2 but not C57BL/6JPAI-1-/- @entity0 . C57BL/6JPAI-1-/- @entity0 showed significantly less @entity4 in the lavage and higher @entity7 in the lung tissue than @entity2 @entity0 at the end of exposure and 4 wk later. After @entity3 exposure, both @entity2 and C57BL/6JPAI-1-/- @entity0 had substantial expansion of the subepithelial area of the medium [diameter (d) = 90-129 microm]- and large (d > 129 microm)-size airways when compared with saline-exposed @entity0 . Subepithelial fibrin deposition was prevalent in @entity2 @entity0 but diminished in C57BL/6JPAI-1-/-. @entity9 expression by nonciliated bronchial epithelial cells was enhanced in @entity3 -exposed @entity2 @entity0 compared with the saline-exposed group. Four weeks after @entity3 inhalation, @entity6 and the expansion of the subepithelial area in the medium and large airways persisted in @entity2 but not C57BL/6JPAI-1-/- @entity0 . We conclude that an active fibrinolytic system can substantially alter the development and resolution of the postinflammatory airway remodeling observed after chronic @entity3 inhalation.

title: Fibrinolysis in @entity3 -induced XXXX .

answer: @entity5


abstract: BACKGROUND: Fetal echocardiography is widely established in the United Kingdom for prenatal diagnosis of @entity2 . This may result in a substantial reduction in incidence at birth because of selected termination of pregnancy. The objective of this population-based study was to determine the incidence of @entity4 with @entity6 (PAIVS) at birth, the impact of fetal echocardiography on this incidence, and to compare the outcome of cases with and those without prenatal diagnosis. METHODS AND RESULTS: From 1991 to 1995, all @entity0 born with PAIVS and all fetal diagnoses in the United Kingdom and Eire were studied. There were 183 live births (incidence 4.5/100,000 live births). The incidence was 4.1 cases per 100,000 live births in England and Wales, 4.7 in Scotland, 6.8 in Eire, and 9.6 in Northern Ireland (P=0.01). There were 86 fetal diagnoses made at a mean of 22.0 weeks of gestation leading to 53 terminations of pregnancy (61%), 4 intrauterine @entity1 (5%), and 29 live births (34%). The incidence at birth would be 5.6 per 100,000 births in England and Wales, 5.3 in Scotland, and unchanged in Eire and Northern Ireland, if there were no terminations of pregnancy and assuming no further spontaneous @entity5 (P=0.28). An initial diagnosis of @entity3 was made in 6 cases, at a mean of 22.3 weeks of gestation with progression to PAIVS by 31.4 weeks. Probability of survival at 1 year was 65% and was the same for live-born @entity0 whether or not a fetal diagnosis had been made. CONCLUSIONS: PAIVS is rare, occurring in 1 in 22,000 live births in the United Kingdom and Eire. Termination of pregnancy has resulted in an important reduction in the live-born incidence in mainland Britain.

title: @entity4 with XXXX : impact of fetal echocardiography on incidence at birth and postnatal outcome. UK and Eire Collaborative Study of @entity4 with Intact Ventricular Septum.

answer: @entity6


abstract: BACKGROUND: A screening colonoscopy is recommended in first-degree relatives (FDRs) of @entity2 @entity0 ; few prospective, controlled studies have evaluated colorectal findings in a population-based screening program. OBJECTIVE: To evaluate the prevalence of @entity2 ( @entity5 and @entity4 ) in this increased-risk population, to compare it with that of average-risk individuals, and to identify features that might allow risk stratification for @entity1 among FDRs. DESIGN: Cross-sectional study. SETTING: Population-based screening program in Trentino, Italy. @entity0 : FDRs of @entity2 @entity0 between 45 and 75 years of age with no history of @entity2 or @entity3 . CONTROLS: Average-risk individuals undergoing screening colonoscopy. INTERVENTION: Screening colonoscopy. RESULTS: @entity1 was found in 33.4% of 1252 FDRs and in 30.3% of 765 controls; advanced @entity1 was found in 11.3% of FDRs and in 6.3% of controls. Odds ratios (ORs) from the multivariate logistic regression analysis adjusted for age, sex, cecal intubation rates, and colon cleansing showed an increased risk of advanced @entity1 (OR 2.41; 95% CI, 1.69-3.43; P < .0001) in FDRs. Age older than 56 years (OR 1.83; 95% CI, 1.15-2.99; P = .013) and male sex (OR 2.17; 95% CI, 1.39-3.10; P < .001) are independent predictors of advanced @entity1 . LIMITATIONS: Italian subjects living in the same geographic area; of 4301 FDRs, 2521 were excluded. CONCLUSIONS: The increased risk of advanced @entity1 supports the current recommendation for colonoscopic screening in this group; age and sex may assist in risk stratification of these individuals.

title: Colonoscopic findings in first-degree relatives of @entity0 with XXXX : a population-based screening program.

answer: @entity2


abstract: The Erika tanker broke in two close to the Atlantic coast of France on December 12, 1999. On December 25th, some heavy fuel oil released by the tanker came ashore along the French Atlantic Coast. Some oil residues and oiled bird feathers were collected all along the Atlantic Shoreline of France after the wreck of the Erika tanker. The aim of this study was to differentiate oil residues and oiled bird feathers related to the Erika oil spill from the ones resulting from the numerous tar ball incidents which had occurred after the Erika oil spill. @entity1 and @entity2 quantification of oil residues allowed differentiation of the samples collected on the north part of the Atlantic Coast from those collected on the south part of the Atlantic shoreline. All oiled birds appear to have been contaminated by the Erika oil. Samples collected on the south part of the Atlantic Coast contain a different molecular fingerprint compared to the Erika oil indicating that they are not related to the Erika oil spill. Bulk and molecular 13C/12C ratio measurements were performed in order to check the discriminative feature and the stability of the isotopic approach. Bulk stable @entity0 isotopic composition has been shown to be a valuable screening correlation tool as it confirms the link of samples collected in the north part of the Atlantic Coast with the Erika oil spill. All the samples collected along the south part of the Atlantic Shoreline exhibit @entity3 -enriched bulk isotopic compositions compared to Erika oil. Molecular isotopic composition of saturated @entity4 and of @entity5 compounds also allows unambiguous differentiation of samples related to the Erika oil spill from those due to tar ball incidents. Over the long-term, when molecular distribution will have been modified by the different processes affecting oil in the marine environment, molecular isotopic composition should then be of particular help for Erika oil residues identification.

title: Molecular and stable XXXX isotopic source identification of oil residues and oiled bird feathers sampled along the Atlantic Coast of France after the Erika oil spill.

answer: @entity0


abstract: UNASSIGNED: @entity4 is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Pycnocycla spinosa Boiss. on the treatment of experimental @entity4 . Mediators involved in @entity0 are @entity5 , interleukins, @entity6 as well as an increase in myeloperoxidase (MPO) activity. Therefore, MPO activity was also determined in this research. @entity8 hydroalcoholic extract (5, 10 and 20 mg/kg) or @entity9 (2, 5 and 10 mg/kg) were administered orally, started 2 h before induction of @entity4 by intrarectal administration of @entity3 (3%) in @entity1 . @entity2 (4 m/kg) was used as the standard drug for comparison. Biochemical evaluation of inflamed colon was done using assay of MPO activity. After 5 days treatments, @entity7 was evaluated. Intrarectal instillation of @entity3 caused significant inflammatory reactions as indicated by macroscopic and microscopic changes. The activity of MPO increased in vehicle treated groups while recovered to normal level by pretreatment of animals with @entity8 extract, @entity9 and @entity2 . @entity8 and @entity9 -treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the vehicle treated negative control group. The beneficial effect of @entity8 was comparable with that of @entity2 . This research has shown the anti-inflammatory potential of @entity8 extract and @entity9 in experimentally induced @entity4 .

title: Anti-inflammatory effect of Pycnocycla spinosa extract and its component @entity9 on @entity3 induced @entity4 in XXXX .

answer: @entity1


abstract: BACKGROUND CONTEXT: @entity0 with @entity3 with concomitant @entity2 ( @entity2 ) and predominance of @entity4 have been shown to have inferior outcome after surgery. Studies comparing outcome according to @entity1 predominance and treatment received are lacking. PURPOSE: To study if adding spinal fusion to the decompression in @entity2 impacts outcome in @entity0 with @entity4 ( @entity4 VAS >=  @entity1 VAS) compared to predominant @entity1 ( @entity4 VAS < @entity1 VAS). @entity0 SAMPLE: The Swedish Spine Register was used and included 1,624 @entity0 operated for @entity2 at the L4-L5 level. OUTCOME MEASURES: Self-reported measures were used, including a visual analogue scale (VAS) for back and @entity1 , the Euroqol-5 (EQ-5D) and the physical and mental component summaries of the Short-form 36 to estimate health related quality of life (HRQoL) and the @entity5 index (ODI) to estimate function. METHODS: Inclusion criterion was single level @entity2 operated on with either decompression only (D) or decompression and instrumented posterolateral fusion (DF). Based on preoperative @entity4 scores, the @entity0 were assigned to one of two groups: @entity1 predominance. The @entity0 completed the outcome protocol at 1 and 2 year follow-up. Statistical analysis was performed using linear regression adjusting for multiple potential confounders. RESULTS: In the adjusted outcome at the 1 year follow-up, @entity0 with predominant @entity1 reported a 7.9 mm more improvement on the VAS for @entity4 with fusion, compared to decompression only (95%CI: 0.7-15.2), p=0.03. Despite more change in the fused group, the reported @entity4 levels remained similar in the decompressed only versus decompressed and fused at the 1 year follow-up (28 vs. 24, p=0.77). The @entity0 with @entity4 benefited from adding fusion in @entity4 7.1 (95%CI: 0.3-13.9, p=0.04), @entity1 8.8 (95%CI: 2-15.7, p=0.01), the ODI 5.7 (95%CI: 1.6-9.9, p=0.006) and the EQ-5D 0.09 (95%CI:1.7-0.02, p=0.02) at the 1 year follow-up as the DF group reported greater change in outcome compared to the D group. At the 2 year follow-up no significant differences were found between decompressed only and decompressed and fused in either the @entity4 predominant groups. CONCLUSION: @entity0 with @entity4 operated with DF report better outcomes in terms of @entity1 , function and HRQoL than @entity0 with only decompression. Although these differences are significant on a group level they may fail to reach minimal clinical significant difference. @entity0 with predominant @entity1 report significantly more improvement in @entity4 with DF compared to D but due to baseline differences in preoperative BP these improvements may not be explained by the added fusion per se. At the two year follow-up no significant differences were observed between the D and DF @entity0 in either the PB or PL groups but greater loss to follow-up in the DF groups could potentially bias these findings.

title: Outcome of decompression with and without fusion in XXXX with @entity2 in relation to @entity1 pattern - A register study of 1,624 @entity0 .

answer: @entity3


abstract: BACKGROUND: Activation of @entity5 oxidase (PHOX) plays a critical role in mediating dopaminergic neuroinflammation. In the present study, we investigated the role of PHOX in @entity4 (MA)-induced @entity6 and inflammatory changes in @entity0 . METHODS: We examined changes in mitogen-activated protein kinases (MAPKs), mitochondrial function [i.e., mitochondrial membrane potential, intramitochondrial @entity2 accumulation, mitochondrial oxidative burdens, mitochondrial @entity3 dismutase expression, and mitochondrial translocation of the cleaved form of protein kinase C delta type (cleaved PKC  )], microglial activity, and pro-apoptotic changes [i.e., cytosolic cytochrome c release, cleaved caspase 3, and terminal deoxynucleotidyl transferase dUDP nick-end labeling (TUNEL) positive populations] after a @entity6 dose of MA in the striatum of @entity0 to achieve a better understanding of the effects of @entity9 , a non-specific PHOX inhibitor, or genetic inhibition of @entity12 (by using @entity12 knockout @entity0 or @entity12 antisense oligonucleotide) against MA-induced dopaminergic @entity6 . RESULTS: Phosphorylation of extracellular signal-regulated kinases ( @entity8 ) was most pronounced out of MAPKs after MA. We observed MA-induced phosphorylation and membrane translocation of @entity12 in the striatum of @entity0 . The activation of @entity12 promoted mitochondrial stresses followed by microglial activation into the M1 phenotype, and pro-apoptotic changes, and led to @entity1 . @entity10 activated these signaling pathways. @entity9 or genetic inhibition of @entity12 significantly protected these signaling processes induced by MA. @entity10 inhibitor @entity7 did not exhibit any additional positive effects against protective activity mediated by @entity9 or @entity12 genetic inhibition, suggesting that @entity10 regulates @entity11 phox activation, and @entity10 constitutes the crucial target for @entity9 -mediated inhibition of PHOX activation. CONCLUSIONS: Our results indicate that the neuroprotective mechanism of @entity9 against MA insult is via preventing mitochondrial burdens, microglial activation, and pro-apoptotic signaling process by the @entity10 -dependent activation of @entity12 .

title: XXXX prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of @entity4 in the striatum of @entity0 via inhibition of @entity11 phox activation by @entity10 .

answer: @entity9


abstract: @entity5 ( @entity5 ) is a spectrum of @entity1 with decreased bone density and @entity2 . Most of the cases of @entity5 are inherited in autosomal dominant fashion with mutations in @entity6 or @entity4 genes. Over last few years, twelve genes for @entity1 have been identified. In this study we have evaluated seven @entity0 with @entity5 from consanguineous Indian families. Homozygosity mapping using SNP microarray was done and selected candidate genes were sequenced. Candidate genes were identified in four out of seven @entity0 studied. Four mutations, namely; a homozygous non-sense (p.Q178*) and a deletion ( @entity11 ) mutations in @entity10 gene, a missense mutation ( @entity12 ) in @entity7 gene and a nonsense mutation ( @entity13 ) in @entity9 gene were identified. In three @entity0 for whom the regions of homozygosity did not reveal any known @entity1 genes, exome sequencing was performed and we identified a known missense mutation ( @entity14 ) in @entity4 gene in one of the @entity0 . As @entity8 gene was not properly covered in exome sequencing in one @entity0 , the gene was sequenced and a homozygous in-frame deletion of four @entity3 ( @entity15 ) was identified. In one of the three cases the exome sequencing did not reveal a mutation in any known @entity5 genes, suggesting the possibility of mutations in an unidentified gene. The phenotypes of all the cases are described. This work proves the power of homozygosity mapping followed by candidate gene sequencing approach for clinical application in consanguineous families.

title: Mutations in XXXX with osteogenesis imperfecta from consanguineous Indian families.

answer: @entity0


abstract: Twelve @entity0 with early infancy onset @entity6 and @entity7 with a mild clinical course are reported. The neuroradiological, clinical, and genetic aspects of this recently recognized @entity7 were reviewed. Five were affected siblings, and all @entity0 had consanguineous parents. @entity6 , a slowly progressive delay in motor development and mild @entity5 constitute the clinical triad of the disease, showing characteristic age-related onset. The clinical findings outlined remarkably slight functional deterioration despite severe lesions on magnetic resonance imaging (MRI), especially in the initial period. Characteristically, mental function is preserved for years after onset of the @entity1 . The MRI lesions do not reflect the progress of disease. The disease probably has an autosomal recessive mode of inheritance even though no metabolic defect has been detected to date. In a more severe variant of the mentioned disease, there is more progressive and severe @entity1 , including ataxia and @entity4 , leading to an inability to walk independently after 10 years of age. In mild variants, however, disease severity varies from @entity6 with near-normal pyschomotor development to mild motor and/or @entity2 . @entity3 were observed in both types but response to drugs was good. The 12 @entity0 reported here confirm the specific and distinguishing clinical and radiological features of the previously reported 51 cases with this new syndrome, while adding some information regarding identification of the disease.

title: XXXX and @entity7 with mild clinical course: a report on 12 new cases.

answer: @entity6


abstract: UNASSIGNED: Psychological distress contributes to impaired quality of life in hematological @entity1 @entity0 . Stepped care treatment, in which @entity0 start with the least intensive treatment most likely to work and only receive more intensive interventions if needed, could improve distress. We aimed to evaluate the outcome of stepped care treatment on @entity3 and physical functioning in @entity0 treated with autologous stem cell transplantation for @entity4 . In the present study, we performed a randomized clinical trial with two treatment arms: stepped care and care as usual. Baseline assessment and randomization occurred during pre-transplant hospitalization. Stepped care was initiated after 6  weeks, consisting of (1) watchful waiting, (2) Internet-based self-help intervention, and (3) face-to-face counseling/ psychopharmacological treatment/ referral. Follow-up measurements were conducted at 13, 30, and 42  weeks after transplantation. Stepped care (n   =   47) and care as usual (n   =   48) were comparable on baseline characteristics. The uptake of the intervention was low: 24 @entity0 started with step 1, 23 with step 2, and none with step 3. Percentages of distressed @entity0 ranged from 4.1 to 9.7  %. Ten percent of @entity0 received external psychological or @entity2 care. No statistically significant differences were found between stepped care and care as usual on @entity3 or physical functioning in intention to treat analyses, nor in per protocol analyses. The stepped care program was not effective in decreasing @entity3 . The low intervention uptake, probably related to the low levels of @entity3 , offers an explanation for this outcome. Future research should take into account @entity0 ' specific care needs. Netherlands Trial Registry identifier: NTR1770.

title: A randomized clinical trial on the effectiveness of an intervention to treat XXXX and improve quality of life after autologous stem cell transplantation.

answer: @entity3


abstract: We analyzed the immunohistochemical expression of the @entity5 , CD44v3, in 46 primary @entity0 @entity2 ( @entity2 ). This is the first time that the v3 splice variant of @entity4 was found to be expressed in @entity0 @entity2 (15 of 46), ranging from 3% to 35% of the cell population in the positive @entity1 . The expression of CD44v3 was observed in @entity1 thicker than 1.0 mm, and one-third of these @entity1 proved to be positive irrespective of the thickness. @entity0 were followed for a minimum of 61 months. The onset of lymph node or organ metastases occurred not later than 58 months and 60 months, respectively. Of the 15 CD44v3 positive @entity1 , 14 were observed in the organ metastatic tumor group, comprising the majority of those cases (14 of 21), and this association proved to be statistically significant compared with the non-metastatic (P<0.05) and lymph-node metastatic cases (P<0.01). CD44v3 expression in @entity2 was also confirmed at the protein and messenger (mRNA) level in several @entity0 @entity2 cell lines using flow cytometry and reverse transcriptase polymerase chain reaction analysis. In parallel to CD44v3, @entity3 expression (determined using immunohistochemistry) was significantly elevated (P<0.05) but only in the organ metastatic group of MM. The 5-year survival of @entity0 having thicker @entity1 than 1.0 mm (where v3 expression occurred) who had CD44v3+ @entity1 was significantly lower than those of the negative ones (35.7% versus 68.2%, respectively; P=0.025). Finally, we observed that the CD44v3-expressing @entity1 were characterized by significantly higher @entity3 expression than the CD44v3-negative @entity1 (P<0.001), indicating a possible correlation between CD44v3- and @entity3 -positive phenotype and the organ metastatic potential of MM.

title: Expression of CD44v3 splice variant is associated with the visceral metastatic phenotype of @entity0 XXXX .

answer: @entity2


abstract: OBJECTIVES: Radical retropubic prostatectomy is the major procedure for curing early @entity1 . In this retrospective study we valued the complications of this surgery and its evolution in time, as well as the efectiveness of the @entity4 preservative treatment in the recovery of urinary continence. MATERIALS AND METHODS: During the period between december of 1998 to january of the 2005 we have treated 168 @entity0 suffering @entity2 clinically confined to the gland by means of retropubic radical prostatectomy. We removed the vesical catheter the fourteenth day of the postoperative and made a clinical monitoring the first, third and sixth month after the surgery, and thereafter every six months. RESULTS: Of the 168 @entity0 who underwent clinical surgery, 15% required postoperative blood transfusion in the immediate postoperative. Other complications, with a lower incidence, were the intestinal perforation, surgical wound @entity3 and the haematoma. The most frequent delayed complications we registered were @entity5 , observed in 164 @entity0 (98%), micturition alterations in 32 @entity0 (19%) and intestinal alterations in approximately 11%. Among the micturitional alterations found, the most frequent (64%) was the Urinary Incontinence (UI). However, most of them were of minor importance (34%) and all improved during the first six months after the surgery. We advised @entity0 with minor and moderate UI to perform pelvic floor muscle training, being very useful since they allowed to anticipate the recovery of continence. CONCLUSIONS: Radical prostatectomy continues to be the most effective treatment for the non @entity2 , in spite of the associated morbidity. The IU is the main factor for the high standard of living these @entity0 . Despite the number of @entity0 with UI being so high, most cases are moderate and minor and may improve with pelvic floor muscle training. Hence, this is a significant tool to tackle this illness, whether in connection with the use of absorbent, the pharmacologic therapy or the use of penile collectors.

title: [Radical prostatectomy complications: evolution and conservative management of XXXX ].

answer: @entity4


abstract: Suprasellar @entity2 represent less than 10% of all intracranial @entity2 . Some of them may be quiescent throughout life, some may become symptomatic as they become enlarged and some disappear spontaneously. In this study we discuss the surgical strategies for endoscopic and endoscope-assisted treatment of suprasellar (Mickey @entity1 ) cysts and analyze the clinical results and experience collected over some years in our department upon doing these operations routinely. Between December 1996 and December 2003, 13 @entity0 (7 female and 6 male @entity0 ), mean age 29 years, underwent endoscopic or endoscope-assisted procedures for @entity4 at our department. The indication for surgical treatment was based on the neurological and radiological examination. The goal of surgical treatment was to normalize the cerebrospinal fluid flow and to establish a communication, permanently, between the cyst cavity and the intraventricular or/and subarachnoid space. Intraoperatively we observed in all @entity0 no complications. Seven of 13 @entity0 , who had received shunt systems in other hospitals before admission in our clinic, remained shunt-free postoperatively. Overall clinical improvement was achieved for a long period of between 6 and 74 months in 11 @entity0 , one developed a psychomotor disturbance and another one, who had @entity3 before treatment, was unchanged postoperatively. Our data suggest that @entity4 are well treated by endoscopic or endoscope-assisted procedures with good clinical outcome and low surgical morbidity.

title: Endoscopic and endoscope-assisted neurosurgical treatment of suprasellar @entity2 (Mickey XXXX cysts).

answer: @entity1


abstract: OBJECTIVE: To compare the results of laparoscopic cholecystectomy (LC) with those of open cholecystectomy (OC) in the treatment of acute @entity1 . DESIGN: A prospective, nonrandomized trial. SETTING: "Virgen de la Arrixaca" University Hospital, El Palmar (Murcia), Spain. @entity0 : One hundred fourteen @entity0 underwent LC, and 110 underwent OC. The @entity0 underwent surgery within 72 hours of the onset of symptoms. The @entity0 were selected for LC or OC depending on the surgeon's experience in laparoscopic surgery. MAIN OUTCOME MEASURES: Operating time, rate of conversion from LC to OC, complications, and length of hospital stay. RESULTS: Conversion from LC to OC was necessary in 15% of the @entity0 . The mean operating time was 77 minutes for the OC group and 88 minutes for the LC group (P<.001). Complications occurred in 14% of the @entity0 in the LC group and in 23% of the @entity0 in the OC group, with no significant differences between the 2 groups (P=.06). The number of moderate or severe complications was similar in both groups, whereas mild complications were more common in the OC group (P<.02). The length of the hospital stay averaged 8.1 days for the OC group and 3.3 days for the LC group (P<.001). CONCLUSIONS: Laparoscopic cholecystectomy is a safe, valid alternative to OC in @entity0 with acute @entity1 . The technique has a low rate of complications, implies a shorter hospital stay, and offers the @entity0 a more comfortable postoperative period than OC.

title: Laparoscopic cholecystectomy vs open cholecystectomy in the treatment of acute XXXX : a prospective study.

answer: @entity1


abstract: @entity1 commonly found in food, especially in fermented vegetables, are potential carcinogens. Therefore, limiting @entity1 in food is critically important for food safety. A @entity8 strain ( @entity8 sp. DMDL 9010) was previously isolated from fermented vegetables by our group, and is not yet fully characterized. A number of phenotypical and genotypical approaches were employed to characterize @entity8 sp. DMDL 9010. Its @entity2 degradation capacity was compared with four other @entity8 strains, including @entity8 719, @entity6 . bulgaricu 1.83, @entity5 1.204, and @entity0 8140, on MRS medium. Compared to these four @entity8 strains, @entity8 sp. DMDL 9010 had a significantly higher @entity2 degradation capacity (P<0.001). Based on 16S rDNA sequencing and sequence comparison, @entity8 sp. DMDL 9010 was identified as either @entity0 or @entity3 . To further identify this strain, the flanking regions (922 bp and 806 bp upstream and downstream, respectively) of the @entity4 dehydrogenase 1 (L-ldh1) gene were amplified and sequenced. @entity8 sp. DMDL 9010 had 98.92 and 76.98% sequence identity in the upstream region with @entity7 and @entity3 IG1, respectively, suggesting that Lactobacillu sp. DMDL 9010 is an @entity0 . It was therefore named @entity0 DMDL 9010. Our study provides a platform for genetic engineering of @entity0 DMDL 9010, in order to further improve its @entity2 degradation capacity.

title: Molecular Characterization of @entity0 DMDL 9010, a Strain with Efficient XXXX Degradation Capacity.

answer: @entity2


abstract: OBJECTIVE: To assess the efficacy and tolerability of @entity4 20mg daily, for the treatment of @entity2 and @entity2 associated with @entity1 . METHOD: An open, non-comparative study undertaken at three centers in three cities of Pakistan. A total of 112 in- or out- @entity0 , presenting with a major @entity2 were included in the study. @entity2 was diagnosed according to DSM IV criteria and a Hamilton Rating Scale for @entity2 (HAMD-D) score of >18 on the first 17 items of the HAM-D-21. After a placebo washout period of 7 days, @entity0 were given a 20-mg fixed dose of @entity4 daily in the morning for a period of 6 weeks. After baseline, regular assessments were made at 1, 2, 4 and 6 weeks. Efficacy measures included the HAMD-D, the Clinical Anxiety Scale, The Clinical Global Impression Severity of Illness Scale (CGI-S), and the Clinical Global Impression Improvement Scale (CGI-I). Tolerability was assessed by any adverse event. The primary therapeutic outcome measures were @entity0 who achieved a 50% or greater reduction in HAMD-D score at the end of the treatment or achieved a reduction in final HAMD-D score of < or = 10 points. The final scores of 1 or 2 for CGI-S and CGI-I were considered as full clinical response. RESULTS: Of 112 cases evaluated, 57 were males and 55 females whose ages ranged from 18 to 65 years. There was a clear and statistically significant efficacy of @entity4 on all the major outcome variables. A total of 88% @entity0 achieved a reduction in the final HAMD-D score at the end of treatment. The total HAM-D score reduced to 10 or less in 73% @entity0 at 6 weeks and by this week 76% and 92% @entity0 achieved a score of 1 or 2 for CGI-S and CGI-I, respectively. The mean Clinical Anxiety Scale score reduced from 12.6 at the baseline to 4.4 at the end of treatment. Safety data was evaluated in all 112 @entity0 and @entity4 was well tolerated. Adverse events were experienced by 10% of @entity0 of whom 4% were dropped from the study. @entity3 was the commonest adverse event reported. CONCLUSION: The study shows that @entity4 is an effective, well-tolerated, and safe drug for the treatment of @entity2 .

title: Efficacy and tolerability of @entity4 20 mg daily in the treatment of @entity2 and @entity2 associated XXXX .

answer: @entity1