abstract: BACKGROUND: @entity3 ( @entity3 ) demonstrated similar results to traditional Roux-en-Y procedures. A possible concern is how to manage a chronic @entity5 when medical therapy results ineffective. Revision of the gastro-jejunal @entity2 , obtaining a Roux-en-Y reconstruction, has already been proposed, but technical details have not been elucidated yet. This video shows how to revise a 200-cm @entity3 to treat chronic @entity5 , by converting the procedure to Roux-en-Y, having a short gastric pouch and a long efferent limb. METHODS: A 51-year-old @entity0 complained of recurrent heartburns 2  months after @entity3 . A gastroscopy witnessed the presence of a 6-cm long gastric pouch with @entity4 and @entity5 in esophagus. Specific medications were ineffective. He underwent a revisional laparoscopic procedure. The efferent limb was measured and consisted of 650  cm. The afferent limb was then divided next to the previous gastro-jejunal @entity2 and a jejuno-jejunal @entity2 was performed distally at 70  cm on the alimentary limb. RESULTS: Total operative time was 50  min. The postoperative stay was uneventful and the @entity0 was discharged in postoperative day four. At 6  months follow-up he is still free of medications without symptoms. CONCLUSIONS: The ideal scenario for the presented technique is the finding of a long efferent limb, in order to fashion a Roux-en-Y limb without the risk of @entity1 . To reach this goal, we suggest the measurement of the whole small bowel intra-operatively, in order to assess the length of the common channel left in place.

title: Laparoscopic Conversion of One XXXX Gastric Bypass to Roux-en-Y Gastric Bypass for @entity5 .

answer: @entity2


abstract: Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosome ends to compensate for sequence loss during DNA replication. It has been detected in 85-90% of all primary @entity0 @entity2 , implicating that the telomerase seems to be reactivated in @entity2 and that such activity may play a role in the tumorigenic process. The purpose of this study was to evaluate telomerase activity, @entity0 telomerase RNA ( @entity6 ), and @entity5 ( @entity5 ) in @entity2 and to determine their potential relationships to clinicopathologic parameters. Frozen and corresponding @entity7 -fixed @entity4 -embedded tissue samples were obtained from 51 @entity0 with @entity3 and analyzed for telomerase activity by using a TRAPeze ELISA kit. Tissue sections of all the samples were further investigated for @entity6 and @entity5 by in situ hybridization and a sensitive immunohistochemical technique, respectively. Telomerase activity was detected in 37 (73%) @entity2 . Telomerase positivity from methacarn-fixed @entity4 blocks was found to be 35% of that from frozen tissues. @entity6 was overexpressed in 46 (90%) samples: 33/37 (89%) with and 13/14 (93%) without telomerase activation. Expression of @entity5 was demonstrated in 40 (78%) cases: 30/37 (81%) with and 10/14 (71%) without telomerase. Telomerase activity correlated well with depth of invasion (P =.037) and @entity2 differentiation (P =.022), whereas @entity6 significantly correlated with nodal @entity1 (P=.047) and @entity2 size (P=.023). These data suggest that reactivated telomerase may play a significant role in the tumorigenesis of @entity3 and may reflect, along with enhanced @entity6 , the malignant potential of the @entity2 . It is noteworthy that methacarn-fixed tissue cannot as yet substitute for the frozen section in the TRAP assay.

title: Expression of telomerase activity, XXXX telomerase RNA, and @entity5 in @entity3 .

answer: @entity0


abstract: UNASSIGNED: Many @entity2 , like @entity3 , @entity8 , addictions and different forms of @entity4 are associated with @entity1 . In the etiology and course of those diseases inflammatory processes are regarded to be an increasingly important factor. They are also a frequently discussed element of the pathology of sleep. In this literature review reports on correlations between poor sleep and inflammatory responses in various @entity2 conditions are discussed. The link between @entity3 , @entity8 and inflammatory cytokines is a complex phenomenon, which has been already confirmed in a number of studies. However, the presence of @entity1 in those conditions, being a common symptom of @entity5 and @entity7 , can be an additional factor having a considerable impact on the immunological processes in mental illnesses. In the analyzed data, a number of studies are presented describing the role of inflammatory markers in @entity1 and psychopathological symptoms of affective, @entity6 , neurogenerative and other disorders. Also attention is drawn to possible implications for their treatment. Efforts to use, e.g., anti-inflammatory agents in psychiatry in the context of their impact on sleep are reported. The aspect of inflammatory markers in the @entity9 as the treatment method in major @entity5 is also discussed. A general conclusion is drawn that the improvement of @entity1 plays a crucial role in the care for @entity2 @entity0 .

title: Sleep and inflammatory markers in different XXXX .

answer: @entity2


abstract: Mitochondrial DNA (mtDNA) mutations have been implicated in a wide range of @entity0 disease. However, its role in @entity2 remains unclear. In this study, the entire mitochondrial genome of 10 hydatidiform moles (HM) and one @entity1 were examined by automated DNA sequencing after amplification by polymerase chain reaction. MtDNA sequences obtained separately from disease tissues (HM and @entity1 ) and @entity0 ' tissues were compared. Of the 133 neutral sequence variants identified, 41 have not been reported to date. Large or small-scale deletion or insertion was not detected in any of the samples studied. A total of six (five in the D-loop and one in the 16S rRNA gene) somatic point mutations were detected in the @entity1 sample, in contrast to none being detected in the HM samples. Somatic mtDNA instability was detected in the D-loop region in three cases of HM as well as in the @entity1 sample. Somatic mtDNA instability appeared in the same nucleotide position, from 303 to 309, within the Conserved Sequence Block II resulting in alteration in length of the homopolymorphic C-tract, reflecting microsatellite instability. The results suggest that mtDNA instability may be an early event occurring at a premalignant stage. Occurrence of multiple somatic mtDNA mutations in @entity1 suggests that mtDNA mutations might play an important role in the molecular pathogenesis of invasive @entity2 .

title: Detection of mitochondrial DNA mutations in XXXX .

answer: @entity2


abstract: While physical activity is an essential factor for muscle performance and development and also for the maintenance of bone mass in the loaded bones, apparently low intensity of physical activity of blind @entity0 may compromise the muscle performance and @entity1 ( @entity1 ). Therefore, the aim was to study whether there are differences in @entity1 of the weight-bearing or non-weight-bearing bones between @entity2 @entity0 and those with normal sight. Nineteen @entity2 premenopausal @entity0 and their matched pairs were recruited to the study. The mean age of the @entity2 @entity0 was 39.9 years (SD 8.1) and that of the @entity0 with normal vision 39.7 years (6.5). @entity1 of the distal radius, femoral neck and trochanter was measured with dual energy X-ray absorptiometry (DXA), and isometric muscle strength of the extremities and trunk with a dynamometer. Between-group differences were compared with paired Student's t-test. The @entity1 at the femur was 8% higher in favour of the group with normal sight, whereas radial @entity1 was similar in the two groups. The t-score was -1.0 (95% confidence interval -1.5 to -0.5) for the femoral neck @entity1 and -0.7 (-1.1 to -0.2) for the trochanter @entity1 in the group with @entity2 . The respective t-scores for the group with normal sight were -0.3 (-0.9 to 0.3) for the femoral neck and 0 (-0.7 to 0.7) for the trochanter. @entity2 seems to be a risk for lower @entity1 of the weight-bearing proximal femur, but not for lower @entity1 of the non-weight-bearing distal radius.

title: Bone mineral density of XXXX @entity0 .

answer: @entity2


abstract: [Purpose] To investigate the effects of combined aerobic and resistance training on glycolipid metabolism and @entity2 levels in @entity1 @entity0 . [Subjects and Methods] Forty-two @entity1 @entity0 were randomized to the conventional therapy group (n = 20) or intensive therapy group (n = 22). The control group contained 20 healthy @entity0 . The conventional therapy group received routine drug therapy and diet control, while the intensive therapy group additionally underwent combined aerobic and resistance training for 12 weeks. The oral glucose tolerance test and cardiopulmonary exercise testing were performed. @entity3 and NF-kBp65 protein and mRNA expressions were determined by qPCR and western blotting. ELISA was used to determine the expression levels of @entity5 , @entity4 , pentraxin-related protein 3, and @entity0 @entity6 . [Results] After exercise training, the intensive therapy group had significantly lower postprandial blood glucose, postprandial insulin, and glycated hemoglobin level and insulin resistance index than the conventional therapy group. The intensive therapy group had significantly lower @entity3 and NF-kBp65 protein and mRNA expressions, and serum @entity5 levels but significantly higher serum @entity4 levels. [Conclusion] Combined aerobic and resistance training can improve glycolipid metabolism and reduce low-grade @entity2 in @entity0 with @entity1 @entity0 .

title: Effects of combined aerobic and resistance training on the glycolipid metabolism and XXXX levels in @entity1 .

answer: @entity2


abstract: Background   @entity3 is a neurodegenerative phenotype characterized by a progressive loss of corticospinal motor tract function. In a majority of affected individuals the pathogenesis remains undetermined. Methods   We identified a series of @entity0 with a phenotype of nonsyndromic @entity2 in whom no diagnosis had been reached before exome sequencing. We measured the expression of interferon stimulated genes (ISGs) in peripheral blood from these @entity0 . Results   Five @entity0 from four families with previously unexplained @entity2 were identified with mutations in either @entity5 (one @entity0 ), @entity4 (one @entity0 ), or @entity6 (three @entity0 from two families). All @entity0 were developmentally normal before the onset of features beginning in the second year of life. All @entity0 remain of normal intellect. Four @entity0 demonstrated normal neuroimaging, while a single @entity0 had features of nonspecific @entity1 . The @entity0 with @entity5 and @entity4 -related disease showed a robust interferon signature. The @entity0 with mutations in @entity6 demonstrated no (two @entity0 ) or a minimal (one @entity0 ) upregulation of ISGs compared with controls. Conclusions   Mutations in @entity5 , @entity4 , and @entity6 can cause a phenotype of @entity2 with normal neuroimaging, or in association with nonspecific @entity1 . Although the presence of an interferon signature can be helpful in interpreting the significance of gene variants in this context, @entity0 with pathogenic mutations in @entity6 may demonstrate no upregulation of ISGs in peripheral blood. However, it remains possible that type I interferons act as a neurotoxin in the context of all genotypes.

title: Mutations in @entity5 , XXXX , and @entity6 Presenting As @entity2 .

answer: @entity4


abstract: A large number of elderly @entity0 with @entity4 ( @entity4 ) are not offered treatments with curative intent, such as allogeneic @entity1 ( @entity1 ), because of fears of @entity2 and perceived futility of intensive treatment. Therefore, the outcomes of @entity1 in elderly @entity4 @entity0 remain poorly defined. We performed a meta-analysis of all previous articles up until September 22, 2015 of @entity1 in @entity4 @entity0 >60 years. The primary endpoints were @entity5 ( @entity5 ) and @entity3 ( @entity3 ) at 6 months and at 1, 2, and 3 years. A total of 13 studies (749 @entity0 ) were included. The pooled estimates and 95% confidence intervals (CI) for @entity5 at 6 months, 1 year, 2 years, and 3 years were 62% (95% CI, 54% to 69%), 47% (95% CI, 42% to 53%), 44% (95% CI, 33% to 55%), and 35% (95% CI, 26% to 45%), respectively. The corresponding numbers for @entity3 were 73% (95% CI, 66% to 79%), 58% (95% CI, 50% to 65%), 45% (95% CI, 35% to 54%), and 38% (95% CI, 29% to 48%), respectively. We found no evidence of publication bias in our primary endpoints, with the exception of relapse, where there appeared to be a relative lack of small studies with high relapse rates. Sensitivity analysis did not identify an overtly influential study for our primary endpoints, with 1 exception in 2-year @entity5 analysis. The present analysis argues against significant publication bias and demonstrates consistency among reports despite differences in @entity0 -, disease-, center-, and transplantation-related characteristics. Our results suggest that reduced-intensity @entity1 is a viable treatment option for elderly @entity4 @entity0 with a 3-year @entity5 of 35% for those over the age of 60. These results argue against using age per se as the sole criterion against @entity1 and would help remove some of the barriers that often preclude curative intent treatment. Correct identification of @entity0 who would benefit from @entity1 can improve outcomes in this frequently undertreated population.

title: Outcomes of Allogeneic Stem Cell Transplantation in Elderly XXXX with @entity4 : A Systematic Review and Meta-analysis.

answer: @entity0


abstract: UNASSIGNED: Ultraviolet (UV) radiation and the @entity2 system are involved in immunosuppression in the skin. As previous in vitro and animal studies suggest a role for mast cells in these mechanisms, biopsies were collected from the non-lesional and lesional skin of @entity0 with @entity7 ( @entity7 ), @entity3 ( @entity3 ), @entity5 ( @entity5 ) and @entity6 . The expression of @entity9 metabolizing enzymes, @entity10 and @entity8 , in tryptase-positive mast cells was analysed using a sequential double-staining method. The results showed that the percentage of mast cells containing @entity10 was significantly higher in lesional than non-lesional skin in all diseases, especially in @entity3 and @entity5 . In addition, the percentage of mast cells containing @entity8 was significantly increased in @entity5 , @entity7 , and @entity1 as well. Interestingly, only about 5-6% and 2% of the mast cells expressed @entity10 and @entity8 , respectively, in the non-lesional skin of psoriatic and @entity7 @entity0 . In contrast, 23-38% and 6-9% of the mast cells were immunopositive for @entity10 and @entity8 , respectively, in the non-lesional skin of @entity5 and @entity3 @entity0 . In @entity0 LAD2 mast cell cultures, about 30% and 15% of the mast cells showed @entity10 and @entity8 , respectively, though the immunostainings of these enzymes were not markedly affected by UVB irradiation. In conclusion, increased proportions of mast cells express @entity9 metabolizing enzymes in the lesional skin. Therefore, mast cells may promote an immunosuppressive environment, e.g., in @entity4 .

title: Mast cells express @entity10 and XXXX in epithelial @entity4 and @entity6 .

answer: @entity8


abstract: @entity5 about a single joint in @entity2 @entity0 may be related to deficits in the central regulation of stretch reflex (SR) thresholds of agonist and antagonist muscles. One boundary of the SR threshold range for elbow flexor and extensor muscles was measured in hemiparetic subjects by analysing electromyographic activity during stretching of relaxed muscles at seven different velocities. For each velocity, dynamic SR thresholds were measured as angles at which electromyographic activity appeared. These data were used to determine the sensitivity of the threshold to velocity and the static SR thresholds for flexors and extensors. In contrast to relaxed muscles in healthy subjects, static flexor and extensor thresholds lay within the physiological range in 11/12 and 4/12 subjects, respectively. This implies that, in the range between the static SR threshold and one of the physiological joint limits, relaxation of the muscle was impossible. Subjects then made slow movements against different loads to determine their ranges of active movement. Maximal flexor and extensor torques were lower in hemiparetic subjects throughout the angular range. In some subjects, ranges were found in which no active torque could be produced in either extensor or both muscle groups. These ranges were related to the boundary values of SR thresholds found during passive muscle stretch. The range in which reciprocally organized agonist and antagonist muscle activity could be generated was limited in all but one subject. When attempting to produce torque from positions outside their measured range of movement, excessive @entity3 occurred, typically producing no or paradoxical motion in the opposite direction. Results suggest a relationship between @entity4 measured at rest and the @entity5 in @entity2 by demonstrating a link between motor @entity1 in the central regulation of individual SR thresholds.

title: Deficits in the coordination of agonist and antagonist muscles in @entity2 XXXX : implications for normal motor control.

answer: @entity0


abstract: OBJECTIVES: Evaluate the efficacy of endovascular embolization for @entity0 with endoscopically unmanageable acute nonvariceal @entity1 as well as the factors that may influence mortality. MATERIALS AND METHODS. Retrospective study over a 4-year period including a historical cohort of 37 consecutive @entity0 (22 @entity0 ), with a mean age of 69.2 years (range, 22-93 years). In most cases (54%), the @entity2 stemmed from a gastrointestinal @entity3 . Technical, primary clinical, and secondary clinical success rates, as well as complication rates, were calculated. Several clinical and angiographic parameters were compared to the early mortality rate using Kruskal-Wallis or Fisher tests. RESULTS: Technical, primary clinical, secondary clinical success rates, and complication rates were, respectively, 89.2%, 83.8%, 88.9%, and 10.8%. The early mortality rate was 32.4%. The APACHE II and @entity4 II scores were strongly correlated with mortality (p=0.001 and p=0.003, respectively). CONCLUSION: Endovascular embolization in @entity0 with endoscopically unmanageable acute nonvariceal @entity1 is effective. However, the mortality rate remains high because of the changes in the clinical condition of these @entity0 .

title: [Transcatheter embolization for endoscopically unmanageable acute nonvariceal XXXX ].

answer: @entity1


abstract: Genetically modified (GM) plants offer an ideal model system to study the influence of single genes that confer constitutive resistance to pathogens on the ecological behaviour of plants. We used phytometers to study competitive interactions between GM lines of spring @entity3 @entity3 carrying such genes and control lines. We hypothesized that competitive performance of GM lines would be reduced due to enhanced transgene expression under pathogen levels typically encountered in the field. The transgenes pm3b from @entity3 (resistance against powdery mildew Blumeria graminis) or @entity4 and glucanase genes from @entity1 (resistance against fungi in general) were introduced with the ubiquitin promoter from @entity2 (pm3b and @entity4 genes) or the actin promoter from @entity0 (glucanase gene). Phytometers of 15 transgenic and non-transgenic @entity3 lines were transplanted as seedlings into plots sown with the same 15 lines as competitive environments and subject to two soil nutrient levels. Pm3b lines had reduced mildew incidence compared with control lines. @entity4 and @entity4 /glucanase lines showed the same high resistance to mildew as their control in low-nutrient treatment and slightly lower mildew rates than the control in high-nutrient environment. Pm3b lines were weaker competitors than control lines. This resulted in reduced yield and seed number. The Pm3b line with the highest transgene expression had 53.2% lower yield than the control whereas the Pm3b line which segregated in resistance and had higher mildew rates showed only minor costs under competition. The line expressing both @entity4 and glucanase genes also showed reduced yield and seed number under competition compared with its control. Our results suggest that single transgenes conferring constitutive resistance to pathogens can have ecological costs and can weaken plant competitiveness even in the presence of the pathogen. The magnitude of these costs appears related to the degree of expression of the transgenes.

title: Competitive performance of transgenic XXXX resistant to powdery mildew.

answer: @entity3


abstract: Aims. @entity7 is associated with adverse outcomes in several cardiac pathologies known to have increased apoptosis, including @entity3 ( @entity3 ). We investigated if @entity7 has proapoptotic effects on @entity1 cardiomyocytes and if its silencing has therapeutic benefits in @entity3 . Methods and Results. The effect of @entity7 on apoptosis during @entity1 was studied in cultured neonatal @entity0 myocytes transfected with agomir or antagomir. Differential gene expression was assessed using microarrays. @entity3 was induced in male C57BL/6 @entity0 randomly assigned to antagomir (n = 6) or control group (n = 7), while sham group (n = 7) had sham operation done. Antagomir group received @entity7 antagomir, while control and sham group @entity0 received vehicle only. At 7 and 28 days, echocardiography was done and thereafter hearts were harvested for analysis of apoptosis by TUNEL method, @entity2 using Masson's trichrome, and @entity4 using @entity5 and @entity6 . @entity7 altered apoptosis genes expression and increased apoptosis in @entity1 cardiomyocytes. Therapeutic inhibition of @entity7 decreased cardiac @entity2 , @entity4 , and apoptosis and significantly improved cardiac function 28 days after @entity3 . Conclusion. @entity7 alters apoptosis genes expression and promotes apoptosis in @entity1 cardiomyocytes, and its silencing attenuates apoptosis, @entity2 , and @entity4 after @entity3 , with significant improvement in cardiac function.

title: MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during XXXX and Its Silencing Improves Cardiac Function after @entity3 .

answer: @entity1


abstract: OBJECTIVES: To evaluate the feasibility and efficacy of @entity6 ( @entity6 ) for extra-hepatic portal @entity4 (EHPVO) with recurrent @entity5 (RVB) in @entity0 . METHODS: From November 2005 to December 2013, 28 consecutive paediatric @entity0 with EHPVO treated with @entity6 for RVB refractory to medical/endoscopic therapy and/or surgical treatment in a tertiary-care centre were followed until last clinical evaluation or @entity2 . The median follow-up time was 36.0 months (range 4.0-106.0 months). RESULTS: Seventeen @entity0 and eleven @entity0 aged 7.1 to 17.9 years (median 12.3 years) weighing 19.0-62.0kg (median 33.5kg) were treated. @entity6 was successfully placed in 17 of 28 (60.7%) of @entity0 via a transjugular approach alone (n=4), a combined transjugular/transhepatic approach (n=9), or a combined transjugular/transsplenic approach (n=4). @entity3 occurred in 6 of 17 (35.3%) @entity0 . The cumulative 1- and 3-year free-from-variceal-rebleeding rates in @entity6 success group were higher than those in @entity6 failure group (75.0% and 67.5% versus 45.5% and 18.2%, respectively, p=0.0075). Compared with the @entity6 failure group, the improvements in the height-for-age z-scores were greater in the @entity6 success group (p=0.017). Procedure-related complication occurred in one @entity0 (3.6%), and no episode of post- @entity6 hepatic @entity1 occurred in any @entity0 . Except one @entity0 in the @entity6 success group died at 115 post-operative days, all @entity0 were alive. CONCLUSIONS: @entity6 is feasible and effective in @entity0 with EHPVO and RVB. @entity6 could represent a less invasive alternative to traditional surgical portosystemic shunting or a valuable treatment option if surgery and endoscopic treatment failed.

title: Transjugular Intrahepatic Portosystemic Shunt for Extra-Hepatic Portal XXXX in @entity0 .

answer: @entity4


abstract: Coarse-grained models are becoming a competitive alternative for modeling processes that occur over time and length scales beyond the reach of fully atomistic molecular simulations. Ideally, coarse-grained models should not only achieve high computational efficiency but also provide accurate predictions and fundamental insight into the role of molecular interactions, the characteristic behavior, and properties of the system they model. In this work we derive a series of monatomic coarse-grained water models mX(REM) from the most popular atomistic water models X = TIP3P, @entity3 /E, TIP4P-Ew, and TIP4P/2005, using the relative entropy minimization (REM) method. Each coarse-grained water molecule is represented by a single particle that interacts through short-ranged anisotropic interactions that encourage the formation of " @entity2 -bonded" structures. We systematically investigate the features of the coarse-grained models in reproducing over 20 structural, dynamic, and thermodynamic properties of the reference atomistic water models-including the existence and locus of the @entity0 . The mX(REM) coarse-grained models reproduce quite faithfully the radial and angular distribution function of water, produce a @entity1 ( @entity1 ), and stabilize the ice I crystal. Moreover, the ratio between the @entity1 and the melting temperature of the crystal in the mX(REM) models and liquid-ice equilibrium properties show reasonable agreement with the results of the corresponding atomistic models. The mX(REM) models, however, severely underestimate the cohesive energy of the condensed water phases. We investigate which specific limitations of the coarse-grained models arise from the REM methodology, from the monatomic nature of the models, and from the Stillinger-Weber interaction potential form. Our analysis indicates that a small compromise in the accuracy of structural properties can result in a significant increase of the overall accuracy and representability of the coarse-grained water models. We evaluate the accuracy of the atomistic and the monatomic anisotropic coarse-grained water models, including the mW water model, in reproducing experimental water properties. We find that mW and mTIP4P/2005(REM) score closer to experiment than widely used atomistic water models. We conclude that monatomic models of water with short-range, anisotropic " @entity2 -bonding" three-body interactions can be competitive in accuracy with fully atomistic models for the study of a wide range of properties and phenomena at less than 1/100th of the computational cost.

title: Coarse-Graining of TIP4P/2005, TIP4P-Ew, XXXX /E, and TIP3P to Monatomic Anisotropic Water Models Using Relative Entropy Minimization.

answer: @entity3


abstract: PURPOSE: In @entity0 with histopathologically proven or suspected @entity1 with possible involvement of the rectum, endorectal ultrasound was performed to determine the sensitivity and specificity of this method with regard to rectal wall involvement and the impact on the following operation. METHODS: In an historical cohort analysis, 85 females with histopathologically proven or suspected @entity1 with possible involvement of the rectum were treated between 1992 and 2001. Endorectal ultrasound was performed with a 7.5 MHz real-time unit, and results of endorectal ultrasound were compared with intraoperative findings and histopathologic diagnosis of 65 @entity0 undergoing operation. A questionnaire was used to evaluate postoperative signs and symptoms. RESULTS: Of 65 @entity0 undergoing surgery, 37 underwent laparotomy with 25 resections of the bowel and 28 laparoscopy. In 31 of 32 @entity0 with suspected rectal wall infiltration, preoperative endorectal ultrasound diagnosis was confirmed. In @entity0 in whom endorectal ultrasound showed no rectal wall involvement, histopathology revealed infiltration in one @entity0 , leading to sensitivity of 97 percent and specificity of 97 percent with regard to rectal wall involvement. In terms of the deepness of rectal wall infiltration, endorectal ultrasound had a sensitivity of 76 percent with regard to infiltration of the muscularis propria and 66 percent for infiltration of the submucosa. Operations led to a significant (P < 0.05) reduction of preoperative symptoms by approximately 60 percent. CONCLUSIONS: Endorectal ultrasound is a useful, noninvasive technique for preoperative evaluation of possible rectal wall involvement in @entity1 . Based on the high sensitivity and specificity, recommendation for laparotomy and bowel resection in cases with suspected rectal involvement can be facilitated.

title: Rectal XXXX : high sensitivity and specificity of endorectal ultrasound with an impact for the operative management.

answer: @entity1


abstract: AIM: A cost-effectiveness analysis was performed for sequential treatments of @entity2 ( @entity2 ) with @entity4 kinase inhibitors (TKIs) after failure of 1st line @entity3 , from a commercial payer perspective in the US. METHODS: A Markov model was developed to simulate lifetime treatment costs and health outcomes for TKI sequences for treatment of @entity0 resistant or intolerant to 1st-line @entity3 . Five health states were included, chronic phase 2nd-line TKI, chronic phase 3rd-line TKI, chronic phase post-TKI, advanced phases, and @entity1 . Efficacy (response achievement, loss of response, transformation, @entity1 ) and safety (adverse events incidence, discontinuation) data are based on clinical trials. Resource utilization, costs, and utilities were based on product labels and publically available data. Uncertainty analyses were conducted for key inputs. RESULTS: In @entity0 failing @entity3 , @entity5 -initiating treatment sequences provide the most survival (  LYs   =   0.2-2.0), QALYs (  QALYs   =   0.2-1.9), and accrue highest @entity2 -related costs (  Costs   =    64,000- 222,000). The average @entity7 per QALY for @entity5 - vs @entity3 -initiating sequences is  100,000 for an @entity3 -resistant population. The average @entity7 per QALY for @entity5 - vs @entity6 -initiating sequences is  170,000 for an @entity3 -resistant population, and  160,000 for an @entity3 -intolerant population. CONCLUSIONS: This analysis suggests that @entity5 is associated with increased survival and quality of life compared to high dose @entity3 and to a smaller extent with @entity6 , among @entity0 resistant or intolerant to 1st-line @entity3 , primarily based on higher cytogenetic response rates observed in clinical studies of @entity5 . Head-to-head studies of sequential use of @entity5 and @entity6 are needed to validate the model findings of improved survival (LYs) with better quality-of-life (QALYs) for @entity0 initiating @entity5 in 2nd-line. However, the model findings (in light of higher cytogenetic response rates with @entity5 ) are supported by other studies showing improved quality-of-life for responders, and improved survival for @entity0 achieving cytogenetic response.

title: Cost-effectiveness analysis of second-line XXXX kinase inhibitor treatment for @entity2 .

answer: @entity4


abstract: INTRODUCTION: @entity1 is prevalent in the elderly, but treatment is often inadequate, particularly in developing countries. The objective of this study was to explore the role of a community-based program in supporting @entity0 with @entity1 in an Indonesian rural community. METHODS: A qualitative study comprising observation and in-depth interviews was conducted in an Integrated Health Service Post for the Elderly (IHSP-Elderly) program in Bantul district (Yogyakarta province). Eleven members of IHSP-Elderly program (ie, @entity1 @entity0 ), 3 @entity2 ( @entity2 ), and 1 district health staff member were interviewed to obtain their views about the role of the IHSP-Elderly program in @entity1 management. Data were analyzed using thematic analysis. RESULTS: @entity2 played a prominent role as the gatekeepers of health care in the rural community. In supporting @entity1 management, @entity2 served members of the IHSP-Elderly program by facilitating blood pressure checks and physical exercise and providing health education. Members reported various benefits, such as a healthier feeling overall, peer support, and access to affordable health care. Members felt that IHSP-Elderly program could do more to provide routine blood pressure screening and improve the process of referral to other health care services. CONCLUSION: @entity2 have the potential to liaise between rural communities and the wider health care system. Their role needs to be strengthened through targeted organizational support that aims to improve delivery of, and referral to, care. Further study is needed to identify the key factors for effective CHW-based programs in rural communities and the incorporation of these programs into the health care system.

title: A Community Health Worker-Based Program for Elderly XXXX With @entity1 in Indonesia: A Qualitative Study, 2013.

answer: @entity0


abstract: Nutrition is one method to counter the negative impact of an exercise-induced injury. Deficiencies of energy, protein and other nutrients should be avoided. Claims for the effectiveness of many other nutrients following injuries are rampant, but the evidence is equivocal. The results of an exercise-induced injury may vary widely depending on the nature of the injury and severity. @entity2 typically result in cessation, or at least a reduction, in participation in sport and decreased physical activity. Limb immobility may be necessary with some injuries, contributing to reduced activity and training. Following an injury, an inflammatory response is initiated and while excess @entity0 may be harmful, given the importance of the inflammatory process for wound healing, attempting to drastically reduce @entity0 may not be ideal for optimal recovery. @entity2 severe enough for immobilization of a limb result in loss of muscle mass and reduced muscle strength and function. Loss of muscle results from reductions in basal muscle protein synthesis and the resistance of muscle to anabolic stimulation. Energy balance is critical. Higher protein intakes (2-2.5  g/kg/day) seem to be warranted during immobilization. At the very least, care should be taken not to reduce the absolute amount of protein intake when energy intake is reduced. There is promising, albeit preliminary, evidence for the use of @entity5 and @entity3 to counter @entity1 and enhance @entity4 , respectively. The overriding nutritional recommendation for injured exercisers should be to consume a well-balanced diet based on whole, minimally processed foods or ingredients made from whole foods. The diet composition should be carefully assessed and changes considered as the injury heals and activity patterns change.

title: Nutritional Support for Exercise-Induced XXXX .

answer: @entity2


abstract: BackgroundScopoletin and its glucoside @entity4 are important secondary metabolites synthesized in plants as a defense mechanism against various environmental stresses. They belong to @entity2 , a class of phytochemicals with significant biological activities that is widely used in medical application and cosmetics industry. Although numerous studies showed that a variety of @entity2 occurs naturally in several plant species, the details of @entity2 biosynthesis and its regulation is not well understood. It was shown previously that @entity2 (predominantly @entity4 and @entity3 ) occur in @entity0 ( @entity0 ) roots, but until now nothing is known about natural variation of their accumulation in this model plant. Therefore, the genetic architecture of @entity2 biosynthesis in @entity0 has not been studied before.ResultsHere, the variation in @entity4 and @entity3 content was assessed by comparing seven @entity0 accessions. Subsequently, a quantitative trait locus (QTL) mapping was performed with an Advanced Intercross Recombinant Inbred Lines (AI-RILs) mapping population EstC ( @entity5  *  Col). In order to reveal the genetic basis of both @entity4 and @entity3 biosynthesis, two sets of @entity1 extracts were made from @entity0 roots and one set was additionally subjected to enzymatic hydrolysis prior to quantification done by high-performance liquid chromatography (HPLC). We identified one QTL for @entity4 and five QTLs for @entity3 accumulation. The identified QTLs explained 13.86% and 37.60% of the observed phenotypic variation in @entity4 and @entity3 content, respectively. In silico analysis of genes located in the associated QTL intervals identified a number of possible candidate genes involved in @entity2 biosynthesis.ConclusionsTogether, our results demonstrate for the first time that @entity0 is an excellent model for studying the genetic and molecular basis of natural variation in @entity2 biosynthesis in plants. It additionally provides a basis for fine mapping and cloning of the genes involved in @entity4 and @entity3 biosynthesis. Importantly, we have identified new loci for this biosynthetic process.

title: Identification of QTL affecting XXXX and @entity3 biosynthesis in @entity0 .

answer: @entity4


abstract: UNASSIGNED: The association between @entity1 and immune-mediated rheumatic conditions is controversial, especially as far as @entity5 ( @entity5 ) is concerned. Furthermore, no clinical feature has been shown to be suggestive of a @entity3 . With the present study, we aim to address both these issues. The study population comprised N  =  1750 @entity0 , including N  =  100 with @entity5 , who attended our tertiary immuno-rheumatology clinic between January 1, 2005 and November 30, 2012. A @entity3 was deemed paraneoplastic if @entity1 had been diagnosed in the 2  years preceding or following its onset. The probability of a significant association between a specific @entity3 and @entity1 was evaluated by computing the odds ratio (OR): N  =  702 @entity0 with @entity2 serving as controls. Furthermore, clinical features distinguishing paraneoplastic @entity3 were searched for by univariate and multivariate analysis. @entity8 ( @entity8 ) [OR 3.6 (CI 95% 1.7-7.5)], @entity5 (OR 5.1 CI 95% 2.9-8.9), @entity6 / @entity7 [OR 12.09 (CI 95% 2.6-55.8)] and @entity4 [OR 3.70 (CI 95% 1.81-7.52)] are associated with @entity1 . At multivariate analysis, older age is associated with @entity1 among @entity8 @entity0 (p  =  0.03), while in the @entity5 group, older age, male gender, and >= 6 tender joints are independent predictors of paraneoplastic @entity5 (p  <  0.0004). Cancer frequently either heralds or follows rheumatic manifestations, including @entity5 . Older age, male gender and a more extensive joint involvement should be considered red flags for paraneoplastic @entity5 .

title: Association between @entity3 and XXXX : results from a clinical practice cohort study.

answer: @entity1


abstract: One of the many applications for which lasers have been proposed in implant dentistry is for the decontamination process. The purposes of this study were to assess possible alterations in @entity4 implants in vitro and in vivo by use of the @entity3 ( @entity2 ) laser and to determine whether new bone formation can occur on previously contaminated implants. In vitro, temperature changes at the bone- @entity4 implant interface were recorded during use of a @entity2 laser-scanning system (Swiftlase). Additionally, the effects of laser irradiation on @entity4 implants at various power settings were examined. In 6 @entity1 , a total of 60 implants and @entity0 resulting from plaque accumulation were treated by air-powder abrasive (the conventional treatment), laser irradiation, or both. Depending on the parameters chosen, melting and other surface alterations were seen in vitro, especially in the superpulse mode. Otherwise, no alterations were found, even at high power settings in the continuous mode. In vivo, corresponding histologic examination of 4-month sections showed evidence of new direct bone-to-implant contact after laser-assisted therapy, especially when the implants had been treated concomitantly with submerged membranes. These results support the hypothesis that peri-implant defects can be treated successfully by laser decontamination without damaging the surrounding tissues in the @entity1 model. Nevertheless, further investigations will be required to determine the clinical efficacy of the treatment.

title: Peri-implant care of ailing implants with the XXXX laser.

answer: @entity3


abstract: Physiological studies with excised stem segments have implicated the plant hormone @entity6 ( @entity5 or auxin) in the regulation of cell elongation. Supporting evidence from intact plants has been somewhat more difficult to obtain, however. Here, we report the identification and characterization of an auxin-mediated cell elongation growth response in @entity1 . When grown in the light at high temperature (29 degreesC), @entity1 seedlings exhibit @entity4 compared with seedlings grown at 20 degreesC. This temperature-dependent growth response is sharply reduced by mutations in the auxin response or transport pathways and in seedlings containing reduced levels of free @entity5 . In contrast, mutants deficient in @entity7 and @entity3 biosynthesis or in @entity2 response are unaffected. Furthermore, we detect a corresponding increase in the level of free @entity5 in seedlings grown at high temperature, suggesting that temperature regulates auxin synthesis or catabolism to mediate this growth response. Consistent with this possibility, high temperature also stimulates other auxin-mediated processes including auxin-inducible gene expression. Based on these results, we propose that growth at high temperature promotes an increase in auxin levels resulting in @entity0 . These results strongly support the contention that endogenous auxin promotes cell elongation in intact plants.

title: High temperature promotes auxin-mediated hypocotyl elongation in XXXX .

answer: @entity1


abstract: BACKGROUND: The role of pathogen-mediated @entity1 in sub-Saharan Africa is receiving more attention, especially in Southern Africa where four countries (including Namibia) are actively working to eliminate @entity3 . With a high concentration of livestock and high rates of companion animal ownership, the influence of zoonotic @entity6 as causes of @entity1 in Namibia remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: The aim of the study was to evaluate exposure to @entity5 , spotted @entity1 and @entity8 group rickettsiae, and @entity4 using IFA and ELISA (IgG) in serum collected from 319 volunteer blood donors identified by the Blood Transfusion Service of Namibia (NAMBTS). Serum samples were linked to a basic questionnaire to identify possible risk factors. The majority of the @entity0 (64.8%) had extensive exposure to rural areas or farms. Results indicated a @entity5 prevalence of 26.1% (screening titre 1   16), and prevalence rates of 11.9% and 14.9% (screening titre 1   100) for spotted @entity1 group and @entity8 group rickettsiae, respectively. There was a significant spatial association between @entity5 exposure and place of residence in southern Namibia (P<0.021). Donors with occupations involving animals (P>0.012), especially @entity2 (P>0.006), were also significantly associated with @entity5 exposure. Males were significantly more likely than females to have been exposed to spotted @entity1 (P<0.013) and @entity8 (P<0.011) group rickettsiae. Three (2.9%) samples were positive for @entity4 possibly indicating low levels of exposure to a pathogen never reported in Namibia. CONCLUSIONS/SIGNIFICANCE: These results indicate that Namibians are exposed to pathogenic @entity1 -causing bacteria, most of which have @entity7 or tick vectors/reservoirs. The epidemiology of febrile illnesses in Namibia needs further evaluation in order to develop comprehensive local diagnostic and treatment algorithms.

title: Exposure and Risk Factors to @entity5 , Spotted Fever Group and Typhus Group Rickettsiae, and XXXX among Volunteer Blood Donors in Namibia.

answer: @entity4


abstract: UNASSIGNED: In the 2013 reclassification of the @entity10 ( @entity10 ), two rare @entity10 ( @entity10 ( @entity9 ), @entity7 ( @entity7 )) and two rare histologic patterns (acute fibrinous and @entity6 (AFOP), bronchiolocentric pattern of @entity3 (BPIP)) are described. All these entities are rare with small series published to date, mostly containing primary and secondary forms of disease. @entity9 is histologically characterized by diffuse polyclonal lymphoid cell infiltrate surrounding the airways and expanding the interstitium. Thin-walled cysts and diffuse ground glass are considered the typical radiologic features. The clinical course is highly variable with corticosteroid responsiveness evident in approximately half of cases. @entity7 is defined histologically by coexisting @entity0 with @entity5 . Dense @entity0 and consolidation are the cardinal radiologic features. A history of recurrent lower respiratory tract @entity2 is frequent. Responses to immunomodulation have not been reported and the rate of progression appears to be highly variable. AFOP is a rare histologic pattern lying within the spectrum of acute/subacute @entity4 , characterized by @entity6 and @entity1 without hyaline membranes. BPIP is characterized histologically by @entity0 and/or inflammation confined to the alveolar interstitium around bronchovascular bundles, overlapping with peribronchial @entity8 and @entity0 in some series. Currently, AFOP and BPIP are both best viewed as histological entities rather than true clinical disorders, in the absence of characteristic associated imaging patterns and clinical features.

title: Rare XXXX : @entity9 and PPFE and rare histologic patterns of @entity3 : AFOP and BPIP.

answer: @entity10


abstract: BACKGROUND: Genetics and environmental factors play a role in the pathogenesis of the complex disease, @entity1 . Two major pathophysiological defects coexist in this disease: impairment of insulin secretion by beta-cells and decreased insulin sensitivity in peripheral tissues. The aim of the study was to examine whether two polymorphisms: the @entity6 substitution in the promoter region of @entity2 gene and the @entity7 @entity4 variant of the @entity5 gene; influence insulin resistance in individuals with positive family history of @entity1 . METHODS: Sixty individuals were included into this study: 28 @entity0 and 32 @entity0 , all of them with normal @entity3 tolerance. Insulin and @entity3 serum levels were were assessed during the OGTT on fasting and at 30 and 120 minutes. Secondary indices of insulin resistance were calculated based on these measurements. Genotyping of the both examined polymorphisms was performed using the restriction fragment length polymorphism method (RFLP). RESULTS: Homozygous and heterozygous carriers of the A allele in position -308 of the @entity2 gene promoter showed higher plasma insulin levels at 120 min OGTT versus GG carriers (44.77 microliters/ml; SD 40.4 vs. 26.82; SD 19.9; p = 0.04) and a higher ratio of the 30 min increment in insulin to the 30 min increment in @entity3 (35.4; SD 21.5 vs. 22.6: SD 21.5; p = 0.03). In addition, homo- and heterozygous carriers of the Q allele at residue 121 of the @entity5 gene showed higher plasma @entity3 levels at 120 min OGTT compared to the KK subjects (5.38 mmol/l, SD 1.19 vs. 4.48, SD 1.11; p = 0.03). CONCLUSION: Our study suggests that both examined polymorphisms: the @entity6 in the promoter region of @entity2 and @entity7 @entity4 variant of the @entity5 ; influence the development of insulin resistance as a prediabetic quantitative trait in a Polish population.

title: [ @entity2 XXXX gene polymorphisms and pre- @entity1 quantitative features in the Polish population].

answer: @entity5


abstract: BACKGROUND: Various measures/scales have been used to assess oral health-related quality of life in @entity0 with @entity3 ( @entity3 ). However, there have been few reports on the validity of questionnaires, and even fewer assessments of their use in Japanese sociocultural conditions. OBJECTIVES: The objectives of the study were: (i) to develop and refine the number of questions concerning @entity1 -related limitations of daily function in the @entity4 questionnaire (LDF-TMDQ, 13 items) in Japanese @entity0 with @entity4 , (ii) to assess factor validity, and (iii) to determine convergent and discriminant validity of the LDF-TMDQ with the observed items within a multidimensional questionnaire. METHODS: Four hundred and fifty-six (85.9%) outpatients with @entity4 were enrolled. The subjects were allocated into two roughly equal groups--E-group (233) for exploratory factor analysis and C-group (223) for confirmatory factor analysis [ @entity2 ( @entity2 )]. RESULTS: The exploratory factor analysis extracted 10 items and three factors. @entity2 showed the revised model to accurately describe the relationships between the measured items. As to convergent validity, the factor 'limitation in executing a certain task' and 'limitation of mouth opening' showed significant correlations with the observed items within the multi-dimensional questionnaire. However, the factor 'limitation of sleeping', show no correlation with any item. As to discriminant validity, all three factors had correlation coefficients below 0.4 with the psychological scale, the personality scale, and the visual analog scale for @entity1 intensity. CONCLUSION: The LDF-TMDQ was reduced from 13 items to 10. The factor validity of the LDF-TMDQ, and the construct validity of 'limitation in executing a certain task' and 'limitation of mouth opening' were confirmed, while that of 'limitation of sleeping' remains to be determined.

title: Development of a new questionnaire to assess @entity1 -related limitations of daily functions in Japanese @entity0 with XXXX .

answer: @entity3


abstract: CONTEXT: The introduction of novel imaging modalities has increased the detection of @entity3 ( @entity3 ) recurrence, potentially justifying the use of a @entity1 ( @entity1 ) with surgery or radiotherapy (RT) rather than a systemic approach. OBJECTIVE: To perform a systematic review of @entity1 for oligometastatic @entity3 recurrence. EVIDENCE ACQUISITION: This systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. We searched the Medline and Embase databases from 1946 to February 2014 for studies reporting on biochemical or clinical progression and/or @entity2 or complications of @entity1 (RT or surgery). Reports were excluded if these end points could not be ascertained or separately analysed, or if insufficient details were provided. Methodological quality was assessed using an 18-item validated quality appraisal tool for case series. EVIDENCE SYNTHESIS: Fifteen single-arm case series reporting on a total of 450 @entity0 met the inclusion criteria. Seven studies were considered of acceptable quality. Oligometastatic @entity3 recurrence was diagnosed with positron emission tomography with coregistered computed tomography in most of the @entity0 (98%). Nodal, bone, and visceral metastases were treated in 78%, 21%, and 1%, respectively. @entity0 were treated with either RT (66%) or lymph node dissection (LND) (34%). Adjuvant @entity4 deprivation was given in 61% of @entity0 (n=275). In the case of nodal metastases, prophylactic nodal irradiation was administered in 49% of @entity0 (n=172). Overall, 51% of @entity0 were progression free 1-3 yr after salvage @entity1 , with most of them receiving adjuvant treatment. For RT, grade 2 @entity2 was observed in 8.5% of @entity0 , with one case of grade 3 @entity2 . In the case of LND, 11% and 12% of grade 2 and grade 3 complications, respectively, were reported. CONCLUSIONS: @entity1 is a promising approach for oligometastatic @entity3 recurrence, but the low level of evidence generated by small case series does not allow extrapolation to a standard of care. @entity0 SUMMARY: We performed a systematic review to assess complications and outcomes of treating @entity3 recurrence with surgery or radiotherapy. We concluded that although this approach is promising, it requires validation in randomised controlled trials.

title: @entity1 -directed Therapy of Regional and Distant Recurrences After Curative Treatment of XXXX : A Systematic Review of the Literature.

answer: @entity3


abstract: Mesenchymal stem cell (MSC) transplantation provides a novel strategy for the treatment of @entity0 disease. MR imaging (MRI) is able to track transplanted stem cells labeled with superparamagnetic @entity3 (SPIO) in vivo. However, the effect of SPIO upon labeled MSCs remains unclear on a cellular level. In this study, the biological characteristics of @entity1 MSCs labeled with home-synthesized SPIO particles were evaluated. The MSCs were isolated from the bone marrow of 5 adult @entity1 and labeled with home-synthesized SPIO particles at a final @entity2 concentration of 20   g/ml. Labeled MSCs were confirmed with Prussian blue staining and transmission electron microscopy. The quantity of @entity2 per cell was determined by atomic absorption spectrometry. Cell viability, proliferation, membranous antigen and multiple differentiation ability were compared between labeled and unlabeled MSCs. The @entity1 MSCs were effectively labeled and the labeling efficiency was approximately 100%, as revealed by Prussian blue staining. The SPIO particles located in the endosomal vesicles of the MSCs were confirmed by transmission electron microscopy. No significant differences were observed in cell viability, proliferation, membranous antigen and multiple differentiation ability between the labeled and unlabeled MSCs (P>0.05). In conclusion, MSCs are able to be effectively labeled by home-synthesized SPIO particles without influencing their main biological characteristics.

title: Assessment of biological characteristics of mesenchymal stem cells labeled with superparamagnetic XXXX particles in vitro.

answer: @entity3


abstract: PURPOSE: To report abnormalities in the @entity9 pathway and other @entity1 risk factors in @entity0 with @entity3 . METHODS: In a study, we investigated 76 consecutive @entity0 who had in- @entity0 evaluation of @entity2 . All @entity0 underwent comprehensive tests for @entity6 including determinations of @entity9 , protein S, @entity7 , and resistance to activated @entity9 and were screened for @entity2 risk factors. Resistance to activated @entity9 was confirmed by a polymerase chain reaction method to detect the specific factor V @entity10 mutation. For comparative purposes, we also screened 209 consecutive inpatients with @entity4 from the same geographic region for resistance to activated @entity9 as well as @entity9 and @entity8 . RESULTS: Ten (29%) of 35 @entity0 with central @entity5 (CRVO) had factor V @entity10 mutation. The factor V @entity10 mutation was detected in four (19%) of 21 @entity0 with @entity5 . The higher frequency in factor V @entity10 mutation compared with the expected 9% mutation prevalence in a white population was highly significant for the central @entity5 group but not for the @entity5 group. In all @entity0 with resistance to activated @entity9 , the factor V @entity10 mutation was detected; 16 were heterozygous, one homozygous. No cases of @entity7 , @entity9 , or @entity8 were detected. Forty (19%) of 209 @entity0 with @entity4 were carriers of the factor V @entity10 mutation. CONCLUSIONS: The prevalence of the factor V @entity10 mutation is similar in @entity0 with central @entity5 and @entity0 with @entity4 and represents a relevant risk factor. Screening for this mutation is therefore recommended in all @entity0 with central @entity5 .

title: XXXX and deficiencies in the @entity9 pathway.

answer: @entity3


abstract: BACKGROUND: Insulin resistance is associated with @entity5 , but its mechanism is unknown. It has been reported that @entity8 deficient ( @entity8 -/-) @entity1 showed insulin resistance without @entity3 2 @entity0 , whereas the @entity7 deficient ( @entity7 -/-) @entity1 showed insulin resistance with @entity3 2 @entity0 . METHODS AND RESULTS: We investigated @entity9 formation in the @entity8 -/- and @entity7 -/- @entity1 at 8 and 20 weeks. The @entity7 -/- @entity1 showed much greater @entity9 formation than the @entity8 -/- and wild- @entity3 @entity1 at 8 weeks. At 20 weeks, the @entity7 -/- @entity1 had greater @entity9 formation than the @entity8 -/- @entity1 , which showed more enhanced @entity9 formation than the wild- @entity3 @entity1 . The @entity8 -/- and @entity7 -/- @entity1 had @entity6 , @entity2 , and insulin resistance. The @entity7 -/- @entity1 had more @entity4 than the @entity8 -/- @entity1 at 8 and 20 weeks. @entity7 expression was detected, but @entity8 expression was not detected in the vessels. CONCLUSIONS: The @entity9 formation in the @entity8 -/- and @entity7 -/- @entity1 appears to be related to abnormalities induced by the altered metabolic milieu in insulin-resistant states. Moreover, because @entity9 formation was much greater in the @entity7 -/- @entity1 than in the @entity8 -/- @entity1 at 8 and 20 weeks, it is suggested that a lack of @entity7 renders the vasculature more susceptible to injury in the abnormal metabolic milieu, and @entity7 may have a protective effect on @entity9 formation. We conclude that @entity7 is protective and retards the development of @entity9 formation in insulin-resistant states.

title: Lack of XXXX causes progressive @entity9 .

answer: @entity7


abstract: UNASSIGNED: @entity4 is a major public health problem in @entity0 , impacting upon the affected individual, their families and others charged with their care e.g. educational establishments, and the food industry. In contrast to most other @entity2 , there is no established cure: current management is based upon dietary avoidance and the provision of rescue medication in the event of accidental reactions, which are common. This strategy has significant limitations and impacts adversely on health-related quality of life. In the last decade, research into disease-modifying treatments for @entity4 has emerged, predominantly for peanut, egg and @entity3 's milk. Most studies have used the oral route (oral immunotherapy, OIT), in which increasing amounts of allergen are given over weeks-months. OIT has proven effective to induce immune-modulation and "desensitization" - that is, an increase in the amount of food allergen that can be consumed, so long as regular (typically daily) doses are continued. However, its ability to induce permanent tolerance once ongoing exposure has stopped seems limited. Additionally, the short- and long-term safety of OIT is often poorly reported, raising concerns about its implementation in routine practice. Most @entity0 experience @entity1 and, although generally mild, severe reactions have occurred. Long term adherence is unclear, which rises concerns given the low rates of long-term tolerance induction. Current research focuses on improving current limitations, especially safety. Strategies include alternative routes (sublingual, epicutaneous), modified hypoallergenic products and adjuvants (anti-IgE, pre/probiotics). Biomarkers of safe/successful OIT are also under investigation. This article is protected by copyright. All rights reserved.

title: Improving the safety of oral immunotherapy for XXXX .

answer: @entity4


abstract: UNASSIGNED: Mosquitoes are blood-feeding insects serving as the most important vectors for spreading @entity0 pathogens and parasites. @entity3 is a viral disease mainly vectored through the bite of Aedes mosquitoes. Its transmission has recently increased in urban and semi-urban areas of tropical and subtropical regions worldwide, becoming a major international public health concern. There is no specific treatment for dengue. Its prevention and control solely depend on effective vector control measures. Mangrove plants have been used in Indian traditional medicine for a wide array of purposes. In this research, we proposed a method for biosynthesis of antiviral and mosquitocidal @entity1 nanoparticles (AgNP) using the aqueous extract of Bruguiera cylindrica leaves. AgNP were characterized using a variety of biophysical analyses, including UV-visible spectrophotometry, Fourier-transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Bruguiera cilyndrica aqueous extract and green-synthesized AgNP were tested against the primary dengue vector @entity5 . AgNP were the most effective. LC50 values ranged from 8.93  ppm (larva I) to 30.69  ppm (pupa). In vitro experiments showed that 30   g/ml of @entity6 significantly inhibited the production of dengue viral envelope (E) protein in vero cells and downregulated the expression of dengue viral E gene. Concerning nontarget effects, we observed that the predation efficiency of @entity4 against A. aegypti was not affected by exposure at sublethal doses of AgNP. Predation in the control was 71.81  % (larva II) and 50.43  % (larva III), while in an AgNP-treated environment, predation was boosted to 90.25 and 76.81  %, respectively. Overall, this study highlights the concrete potential of green-synthesized AgNP in the fight against @entity2 . Furthermore, B. cylindrica-synthesized AgNP can be employed at low doses to reduce larval and pupal population of A. aegypti, without detrimental effects of predation rates of mosquito predators, such as @entity4 .

title: Nanoparticles in the fight against mosquito-borne diseases: bioactivity of Bruguiera cylindrica-synthesized nanoparticles against XXXX (in vitro) and its mosquito vector @entity5 (Diptera: Culicidae).

answer: @entity2


abstract: At first, this article comprises the innovative programme of the international "Early Detection and Intervention" research and then shows results of the "Cologne/Bonn Early Recognition - CER" project on @entity2 , the first longterm prospective study on @entity0 in potentially initial prodromal stages prior to the first @entity3 manifestation. At re-examination at an average of 9.6 years later, 79 of 160 @entity0 had subsequently developed a @entity3 according to DSM-IV criteria. Prediction values for the complete range of prodromal symptoms, for 5 subsyndromes and for individual symptoms were assessed. Best prediction values with a high positive predictive power (71 - 91 %) and a low rate of false-positive predictions (7.5 - 1.9 %) were achieved for 10 symptoms and symptom complexes mainly out of the group of thought, speech and @entity1 . As only unsatisfactory prediction values for other prodromal symptom definitions were reported, e.g. the commonly used DSM-III-R definition, empirical evidence for the possibility of diagnosing @entity2 as early as in the initial prodromal stage, has been found for the first time. In the following, this article considers essential initiatives for the development, performance and evaluation of a promising early intervention programme based on the results found. In Germany, within the project unit "Early Recognition and Intervention" of the competence network " @entity2 ", such a programme has been initiated. Late prodromal stages are defined by attenuated or transient @entity3 and early prodromal stages by the presence of at least one of the highly predictive prodromal symptoms from the CER-study or decline in psychic functions in combination with other risk factors. Intervention strategies are a multimodal psychological programme for the intervention in early prodromal stages and a combination of psychotherapy with atypical neuroleptic drugs in the late prodromal stages. If such strategies were able to suppress the progress to first @entity3 , this prevention could be classified as a primary prevention, not with regard to the prodromal symptoms but to frank/manifest @entity2 .

title: [Is there a primary prevention of XXXX psychiasis?].

answer: @entity2


abstract: BACKGROUND: @entity4 negative @entity1 ( @entity1 ) include @entity8 ( @entity8 ), @entity9 ( @entity9 ) and @entity7 ( @entity7 ). the @entity5 @entity6 mutation has been introduced since 2008 as a major diagnostic criterion on the one hand and on the other hand, it would be linked to increased risk of @entity3 . AIM: This study aimed to evaluate the association of @entity5 mutation and @entity3 events in @entity1 . METHODS: A retrospective study concerning 45 @entity4 negative @entity1 @entity0 (mean age=53 old years, sex ratio=0.8) was conducted. RESULTS: They were classified as @entity8 (22 @entity0 ), @entity9 (17 @entity0 ), @entity7 (3 @entity0 ) and atypical @entity1 (3 @entity0 ). The @entity5 mutation was found in 64.4% of @entity0 : 72.7% of @entity8 @entity0 , 47% of @entity9 @entity0 and 66.7% of @entity7 @entity0 . @entity3 events were recorded in 11 @entity0 (24.4%). Cerebral arteries and portal vein were the most frequent localizations. The @entity5 mutation was an independent risk factor of @entity3 events. CONCLUSION: Consequently, it seems that screening for @entity5 mutation in @entity4 negative @entity1 could play a role in identifying @entity0 at high risk of @entity2 .

title: The @entity5 mutation in @entity1 : A predictive factor of XXXX .

answer: @entity3


abstract: BACKGROUND: @entity4 (IM) is a first choice drug for treatment of @entity3 ( @entity3 ), with a widely accepted concentration threshold of 1000ng/ml being used as a target for therapeutic drug monitoring. Once adherence to the pharmacotherapeutic regimen is of paramount importance during the long treatment course of @entity3 , the measurement of hair IM concentrations could be a surrogate of the @entity0 's exposure to the drug. METHODS: IM was extracted from a 5mg hair sample by a liquid-liquid extraction with @entity1 , and IM-d8 was used as @entity5 ( @entity5 ). After evaporation, and reconstitution in @entity2 , the extract was injected into a LC-MS/MS system. Compounds were eluted on a C8 column in isocratic mode. IM and @entity5 were identified in positive electrospray ionization mode using ion transitions of m/z 494.5>394.5 and 503.0>394.3 respectively. The method was applied to 102 paired hair and samples obtained from @entity3 @entity0 . Treatment response was evaluated according to the European LeukemiaNet recommendations. RESULTS: The assay was validated in the concentration range of 0.5-25ng/mg, with intra- and inter-assay imprecisions of <13.1% and <9.3%, respectively. The limits of quantification and detection were 0.5 and 0.15ng/mg, respectively. Median hair IM concentrations are significantly smaller in @entity0 with therapeutic failure when compared with @entity0 with partial or optimal response (4.63 vs. 7.93, p=0.040), the same trend presented by median plasma IM concentrations (629.5 vs. 1084.8, p=0.009). An IM hair concentration below 5.8ng/mg has 83% sensibility and 70% specificity to identify @entity0 with therapeutic failure. CONCLUSIONS: A fast, sensitive, and selective LC-MS/MS method allowing quantification of IM in hair samples was developed and validated. @entity3 @entity0 with therapeutic failure had significantly lower hair IM concentrations when compared with @entity0 with optimal response. These preliminary findings may support the use of hair as a matrix for IM monitoring in clinical settings, with significant logistic advantages over the collection of venous blood, particularly in developing countries.

title: First report of XXXX measurement in hair: Method development and preliminary evaluation of the relation between hair and plasma concentrations with therapeutic response in @entity3 .

answer: @entity4


abstract: During apoptosis, activated caspases cleave the translation initiation factor eIF4G. This cleavage disrupts cap-dependent mRNA translation initiation within the cell. However, a specific subset of mRNAs can still be recruited for protein synthesis in a cap-independent manner by the residual initiation machinery. Many of these mRNAs, including cell death related mRNAs, contain internal ribosome entry sites (IRESes) that promote their enhanced translation during apoptosis. Still other mRNAs have little dependence on the cap recognition mechanism. The expression of the encoded proteins, both anti- and pro-apoptotic, allows for an initial period of attempted cell survival, then commitment to cell death when damage is extensive. In this study we address the translational regulation of the stress and apoptosis-related mRNAs in @entity0 : BiP ( @entity6 ) ( @entity5 ), @entity1 ( @entity1 ), p53 ( @entity4 ), Bcl-2 ( @entity3 ) and Apaf-1 ( @entity2 ). Altered translational efficiency of these messages was observed upon depletion of cap-dependent translation and induction of apoptosis within the @entity0 gonad. Our findings suggest a physiological link between the cap-independent mechanism and the enhanced translation of @entity6 and @entity3 . This increase in the efficiency of translation may be integral to the stress response during the induction of physiological apoptosis.

title: Induction of cap-independent BiP ( @entity6 ) and Bcl-2 ( XXXX ) translation in response to eIF4G (IFG-1) depletion in @entity0 .

answer: @entity3


abstract: @entity6 after @entity2 is associated with poor neurological outcomes. Current therapies are limited to osmotic agents, such as @entity7 ( @entity7 ), which reduce intracranial pressure. Although studies have demonstrated @entity0 following @entity7 , tissue survival has not been thoroughly examined. Additionally, the efficacy of promising pharmacological agents has not been evaluated for synergy with osmotic agents. @entity8 is an FDA-approved @entity4 receptor antagonist that may exert both osmotic and anti-inflammatory effects. In this study, @entity1 were subjected to @entity5 prior to treatment with 5 % @entity7 bolus +5 % @entity7 maintenance ( @entity7 ), @entity8 alone (Con), @entity8 +5 % @entity7 maintenance (Con + @entity7 ), or @entity8 +5 % @entity7 bolus +5 % maintenance (Con + HSb). Treatments were initiated at six (Early) or 24 h (Late) following @entity2 and @entity1 were euthanized at 48 h to evaluate @entity3 volume, @entity6 , and microglia/macrophage activation. @entity3 volume and @entity6 in the Early @entity7 , Early Con, and Late @entity7 groups were significantly reduced compared with controls. Interestingly, only the Early Con group demonstrated reduced microglia/macrophage activation. These data suggest an anti-inflammatory mechanism for @entity8 and provide support for a multipronged approach combining osmotic agents with compounds that inhibit the neuroinflammatory response to @entity2 .

title: The Effects of Clinically Relevant Hypertonic Saline and XXXX Administration on Ischemic Stroke.

answer: @entity8


abstract: UNASSIGNED: BACKGROUND Chronic subdural @entity4 generally occurs in the elderly. After @entity6 evacuation surgery, the development of @entity5 is a very rare entity. CASE REPORT We report the case of a 41-year-old @entity0 with an @entity5 complication after @entity6 evacuation. Under general anesthesia, the @entity0 underwent a large craniotomy with closed system drainage performed to treat the @entity6 . After @entity6 evacuation, there was epidural leakage on the following day. CONCLUSIONS Although @entity1 is the most common risk factor in young CSDH @entity0 , some other predisposing factors may exist. @entity2 can cause EDH. Craniotomy and drainage surgery can usually resolve the problem. Because of rapid dynamic intracranial changes, epidural leakages can occur. A large craniotomy flap and @entity3 drainage in the operation area are key safety points for neurosurgeons and hydration is essential.

title: Epidural XXXX Complication after Rapid Chronic Subdural @entity4 Evacuation: A Case Report.

answer: @entity4


abstract: AIM: We aimed to investigate the retrobulbar blood circulation using Colour Doppler Imaging (CDI) in type 1 @entity1 @entity0 and adolescents who had no @entity1 and to compare the results with their healthy peers. METHODS: Forty-nine @entity0 with @entity1 with no @entity3 on fundoscopic examination were included in the study. Forty-nine healthy @entity0 were defined as the control group. Central retinal artery (CRA), @entity2 ( @entity2 ) and posterior ciliary artery (PCA) were examined with Doppler US bilaterally. Peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive indices (RI) for each artery were recorded. RESULTS: Blood flow velocity of the @entity2 was significantly different in @entity1 @entity0 (p<0.05). EDV of the @entity2 was significantly higher (p=0.011) and RI was significantly lower (p=0.027) in @entity0 with @entity1 duration of longer than 5 years. RI of the CRA was significantly higher in @entity0 who had higher microalbuminuria levels (p=0.016). CONCLUSION: EDV of the @entity2 increases and RI of the @entity2 decreases in @entity1 duration longer 5 years. Raised AER increases RI of the CRA. These findings may be the initial changes in the arterial circulation before @entity4 develops.

title: Doppler ultrasonography imaging of hemodynamic alteration of retrobulbar circulation in type 1 @entity1 @entity0 and adolescents without XXXX .

answer: @entity3


abstract: UNASSIGNED: This study examined associations between @entity0 characteristics, health behaviors, and health outcomes and explored the role of health literacy as a potential mediator of outcomes. English- and Spanish-speaking adults with @entity2 2 @entity1 used a bilingual multimedia touchscreen to complete questionnaires. The behavioral model for vulnerable populations guided multivariable regression and mediation testing. Dependent variables were @entity1 self-care, health status, and satisfaction with communication. Independent variables included sociodemographic and clinical characteristics, health literacy, health beliefs, and self-efficacy. Spanish speakers had lower health literacy and poorer physical, mental, and overall health compared to English speakers. Higher health literacy was associated with less social support for diet, fewer diet and medication barriers, younger age, higher @entity1 knowledge, and talking with health care professionals to get @entity1 information. In contrast to expectations, health literacy was not associated with @entity1 self-care, health status, or satisfaction with communication, and it did not mediate the effects of other factors on these outcomes. @entity1 self-efficacy was significantly associated with health behaviors and outcomes. The association between Spanish language preference and poorer health was not mediated by this group's lower health literacy. Increasing health-related self-efficacy might be an important clinical strategy for improving outcomes in underserved @entity0 with @entity2 2 @entity1 .

title: Health Literacy and @entity0 -Reported Outcomes: A Cross-Sectional Study of Underserved English- and Spanish-Speaking XXXX With Type 2 Diabetes.

answer: @entity0


abstract: In the present study, our aim is to investigate the effects of the treatment modality, @entity4 , @entity7 and @entity1 on quality of life (QoL) in @entity5 ( @entity5 ). Twenty-six @entity0 with @entity5 on conservative management, 68 @entity0 on haemodialysis (HD), 47 @entity0 on continuous ambulatory peritoneal dialysis (CAPD) and 66 healthy controls were enrolled in the study. QoL was measured by means of the Short Form-36 (SF-36) and subscale scores were calculated. All @entity0 were evaluated for the presence of @entity4 using the Structured Clinical Interview for Diagnostic and Statistical Manual of @entity3 , Fourth Edition @entity2 - Clinician Version. The severity of @entity4 was evaluated by means of the Beck Depression Inventory (BDI). Serum @entity6 ( @entity6 ), ferritin, albumin, haemoglobin and haematocrit (Hct) levels were measured. All the SF-36 subscale scores were lower in the @entity0 groups compared with control group. The SF-36 scores were higher and BDI scores were lower in the CAPD group than @entity5 and HD groups. In @entity0 with @entity4 , all SF-36 subscale scores were lower than that of the @entity0 without @entity4 . There was a significant negative correlation between all the SF-36 subscale scores and the BDI scores. There was a significant positive correlation between the SF-36 physical and total summary scores and the Hct value and serum albumin levels, but an inverse correlation between the SF-36 physical, mental and total summary scores and the serum @entity6 level in the HD @entity0 . The authors suggest that the treatment modality, @entity4 , @entity7 and @entity1 have an important role on QoL in @entity5 .

title: Quality of life in @entity5 : effects of treatment modality, XXXX , @entity7 and @entity1 .

answer: @entity4


abstract: UNASSIGNED: In the present study, we evaluated the safety and efficacy of immediate surgical bipolar plasmakinetic transurethral resection of the prostate (PK-TURP) for @entity0 with @entity4 ( @entity4 ) with acute urinary retention (AUR). We conducted a retrospective analysis of clinical data of @entity4 @entity0 who received PK-TURP. A total of 1126 @entity4 @entity0 were divided into AUR (n = 348) and non-AUR groups (n = 778). After the urethral catheters were removed, the urine white blood cell (WBC) count in the AUR group significantly increased compared with the non-AUR group (P < 0.01). However, there was no significant difference in international prostate symptom score, painful urination, and maximal urinary flow rate. The duration of hospitalization of the AUR group was longer than that of the non-AUR group (P < 0.001). A total of 87.1% (303/348) @entity0 in the AUR group and 84.1% (654/778) @entity0 in the non-AUR group completed all of the postoperative follow-up visits. The incidence of @entity3 in the AUR group within 3 months after surgery was significantly higher than that in the non-AUR group (P < 0.01). The incidence of temporary urinary incontinence in the AUR group did not exhibit significant difference. During 3-12 months after surgery, there were no significant differences in major complications between the two groups. Multivariate regression analyses showed that age, postvoid residual, maximal urinary flow rate, @entity1 , and @entity2 , but not the presence of AUR, were independent predictors of IPSS post-PK-TURP. In conclusion, immediate PK-TURP surgery on @entity0 accompanied by AUR was safe and effective.

title: The effect of immediate surgical bipolar plasmakinetic transurethral resection of the prostate on XXXX with acute urinary retention.

answer: @entity4


abstract: OBJECTIVE: To compare @entity0 with @entity5 ( @entity5 ) and @entity4 ( @entity4 ) with regard to their awareness of @entity2 , self-care, and motor-related @entity1 . BACKGROUND: Unawareness of deficits, a clinically important symptom, is found in @entity5 . It has been hypothesized to be associated with @entity6 but has been little studied in other @entity3 . Because @entity4 has a different anatomic-pathologic substrate, a comparison of impairment of awareness in @entity5 and @entity4 may shed light on the neural basis of this phenomenon. METHOD: Impairment of awareness was measured as the difference between @entity0 self-report and caregiver ratings of @entity0 abilities on questionnaires tapping @entity2 , self-care, and motor function. These "discrepancy scores" were then compared between the two diagnostic groups and examined in relation to selected neuropsychological test data. RESULTS: In general, both @entity5 and @entity4 @entity0 rate themselves as being less impaired than do their caregivers. The two diagnostic groups, @entity5 and @entity4 , differ significantly, however, on awareness discrepancy measures in the cognitive domain. In their ratings of @entity0 cognitive skills, @entity5 caregivers rate @entity0 as significantly more impaired than @entity0 rate themselves, whereas @entity4 caregivers and @entity0 do not differ significantly on these ratings. Impaired awareness in @entity4 but not in @entity5 is associated with poorer overall cognitive function and performance on tests measuring memory, attention, and constructional ability. CONCLUSIONS: Both @entity5 and @entity4 @entity0 display @entity2 in multiple domains, including motor-related neurologic function. @entity4 @entity0 with comparatively intact cognitive function display relatively preserved @entity1 .

title: Clinical and neuropsychological correlates of XXXX in @entity5 and @entity4 : a comparative study.

answer: @entity2


abstract: UNASSIGNED: This study evaluates the concept of using zerovalent @entity0 (ZVI) powder or nanoscale zerovalent @entity0 (NZVI) particles in combination with a low frequency (150 kHz) AC electromagnetic field (AC EMF) to effectively remove @entity1 ( @entity2 ) from groundwater and saturated soils. ZVI and NZVI are ferromagnetic, which can induce heat under applied AC EMF. The heat generated by ZVI and NZVI induction can increase the rate of dechlorination, according to Arrhenius' equation, and increase the rate of @entity2 desorption from @entity2 -sorbed soil. Both dechlorination and @entity2 desorption enhance the overall @entity2 removal rate. We evaluated this novel concept in laboratory batch reactors. We found that both ZVI and NZVI can induce heat under applied AC EMF up to 120   C in 20 min. Using ZVI and NZVI with AC EMF enhanced dechlorination of dissolved @entity2 (no soil) up to 4.96-fold. In addition to increasing the temperature by ZVI and NZVI induction heating, AC EMF increased intrinsic ZVI and NZVI reactivity, ostensibly due to accelerated corrosion, as demonstrated by the increased ORP. In a soil-water- @entity2 system, NZVI together with AC EMF thermally enhanced desorption of @entity2 from soil and increased the degradation of @entity2 up to 5.36-fold compared to the absence of AC EMF. For the first time, this study indicates the potential for ZVI and NZVI coupled with AC EMF as a combined remediation technique for increasing the rate and completeness of in situ cleanup of adsorbed phase contaminants.

title: Electromagnetic Induction of Zerovalent @entity0 (ZVI) Powder and Nanoscale Zerovalent @entity0 (NZVI) Particles Enhances Dechlorination of XXXX in Contaminated Groundwater and Soil: Proof of Concept.

answer: @entity1


abstract: UNASSIGNED: High-frequency stimulation (HFS) of the anterior nucleus of thalamus (ANT) is a new and alternative option for the treatment of intractable @entity2 . However, the responder rate is relatively low. The present study was designed to determine the effect of @entity5 ( @entity5 ) in ANT on chronic spontaneous recurrent @entity3 and related pathological pattern in intra-hippocampal @entity4 @entity0 model. We found that @entity5 (1Hz, 100 s, 300 A), but not HFS (100Hz, 100 s, 30 A), in bilateral ANT significantly decreased the frequency of spontaneous recurrent @entity3 , either @entity3 or tonic-clonic generalized @entity3 . The anti- @entity2 effect persisted for one week after @entity5 cessation, which manifested as a long-term inhibition of the frequency of @entity3 with short (20-60s) and intermediate duration (60-120s). Meanwhile, @entity5 decreased the frequency of high-frequency oscillations (HFOs) and interictal spikes, two indicators of @entity3 severity, whereas HFS increased the HFO frequency. Furthermore, @entity5 decreased the power of the delta band and increased the power of the gamma band of hippocampal background EEG. In addition, @entity5 , but not HFS, improved the performance of chronic @entity2 @entity0 in objection-location task, novel objection recognition and freezing test. These results provide the first evidence that @entity5 in ANT alleviates @entity4 -induced chronic @entity2 and @entity1 , which may be related to the modulation of the hippocampal EEG rhythm. This may be of great therapeutic significance for clinical treatment of @entity2 with deep brain stimulation.

title: Low-frequency stimulation in anterior nucleus of thalamus alleviates @entity4 -induced chronic XXXX and modulates the hippocampal EEG rhythm.

answer: @entity2


abstract: INTRODUCTION: @entity9 -like @entity4 (SPTL-AB) and @entity4 ( @entity4 ) are rare @entity4 with varying clinical courses. There is no standard treatment, although chemotherapy and hematopoietic stem cell transplantation are commonly used. We describe results using @entity8 for @entity0 and adults with these disorders. METHODS: We identified 15 @entity0 (12 adults, 3 @entity0 ) who were treated with @entity8 between 2000 and 2010 from the Memorial Sloan-Kettering @entity1 Center @entity3 database, the @entity1 Center Registry, and the National @entity1 Institute (NCI) @entity3 database. There were 8 females and 7 males, with a median age of 45 years (range, 3 years to 85 years). All @entity0 had stage IV disease. Two of 15 and 4 of 15 @entity0 had documented @entity4 and SPTL-AB, respectively; others were presumed to have SPTL-AB. @entity8 was administered at flat doses corresponding to 91 to 339 mg/m(2)/d. Two of 15 @entity0 received concurrent denileukin diftitox. Two @entity0 received @entity8 as maintenance therapy and were not evaluable for response. RESULTS: Among those treated with @entity8 alone, the overall response rate (ORR) was 82% (6/11 complete response [CR], 3/11 partial response [PR]). One of the 2 @entity0 treated with concomitant denileukin diftitox responded for an ORR of 10/13 (77%), including 54% CR and 23% PR. Median progression-free survival was 38.4 months; median duration of response was 26.3 months. Six @entity0 developed @entity5 and 9 developed @entity2 ; one @entity0 developed dose-limiting @entity7 . One pediatric @entity0 developed @entity6 . CONCLUSIONS: In this retrospective series, @entity8 showed a high response rate in SPTL-AB and @entity4 . It was generally well-tolerated with durable responses; therefore, @entity8 represents a promising therapy for @entity0 and adults with these disorders.

title: @entity8 is active against @entity9 -like XXXX in adult and pediatric populations.

answer: @entity4


abstract: A prospective study of @entity0 with @entity12 was undertaken to study the experience with an open intraperitoneal underlay technique utilizing a bilayer prosthetic mesh. From September 1998 to March 2001, 102 @entity0 underwent repair with a bilayer expanded @entity8 (ePTFE) and @entity14 mesh placed intraperitoneally and fixed in place with full-thickness abdominal muscle wall sutures to achieve a 5-cm underlay of the @entity13 circumferentially. There were 67 females and 35 males ranging in age from 29 to 76 years (mean 53 years). Average @entity0 weight was 207 lb with 64 @entity0 in the @entity1 category. Forty @entity0 presented with recurrent @entity6 . Mean operative time was 103 minutes with an average diameter hernia defect size of 15 cm. Median hospital stay was 3 days. There was no surgical mortality, and major morbidity occurred in six @entity0 (2 wound @entity3 , one @entity9 , one @entity7 , one @entity2 , and one @entity5 ). Mean follow-up is 28 months (range 12-42 months). No recurrence has been found with 100 per cent follow-up to date. No @entity11 or enteric @entity4 have occurred during the follow-up period. The open intraperitoneal underlay mesh technique can be performed with a zero per cent early recurrence rate. Bilayer prosthetic mesh composed of ePTFE and @entity14 can be safely placed intraperitoneally without causing @entity10 .

title: Intraperitoneal underlay @entity12 repair utilizing bilayer expanded XXXX and @entity14 mesh.

answer: @entity8


abstract: CONTEXT: Attitude of fresh graduates toward @entity1 @entity0 is important to bridge the treatment gap due to @entity3 . Psychiatry as a subject has been neglected in the undergraduates of MBBS. AIMS: (1) To compare the attitude of medical students and interns in a medical college toward @entity3 and psychiatry. (2) To assess the impact of @entity1 training on attitude toward the mentally ill @entity0 and @entity3 . SETTINGS AND DESIGN: Cross-sectional, single assessment study conducted at a tertiary hospital. SUBJECTS AND METHODS: @entity0 consisted of medical students of 1(st) and 2(nd) year who didn't have any exposure to psychiatry and interns, who had completed their compulsory 2 week clinical posting in psychiatry. @entity0 were individually administered sociodemographic proforma, General Health Questionnaire-12 (GHQ-12), opinion about @entity3 (OMI) scale, and attitude to psychiatry-29 ( @entity2 -29) scale. STATISTICAL ANALYSIS: Standard descriptive statistics (mean, percentage), Chi-square test. RESULTS: A total of 135 @entity0 formed the study sample, with 48, 47, and 40 @entity0 from 1(st) year, 2(nd) year and interns, respectively. Mean GHQ score was 14.03 for the entire sample. There was better outlook of interns toward psychiatry and @entity0 with @entity1 in comparison to fresh graduate students in some areas. Overall, negative attitude toward @entity3 and psychiatry was reflected. CONCLUSIONS: Exposure to psychiatry as per the current curriculum seems to have a limited influence in bringing a positive change in OMI and psychiatry.

title: Impact of psychiatry training on attitude of medical students toward XXXX and psychiatry.

answer: @entity3


abstract: The purpose of this work is to review the result of radiotherapy in the treatment of @entity3 in pediatric @entity0 . Between 1986 and 1998, 66 @entity0 (45 @entity0 and 21 @entity0 ) received postoperative irradiation in our institute. Their mean age was 8.29 years. Irradiation was performed by linear accelerator, 36 Gy were applied in the high risk group (partial @entity2 resection, @entity2 cell positivity in the liquor, @entity1 within the central nervous system) and 30 Gy in the low risk group (total @entity2 resection, negative liquor cytology, no @entity1 within the central nervous system) on the entire cerebrum and spinal cord. This was followed in both groups by the application of 20-20 Gy boost irradiation on the posterior scala. Studying the survival it has been found that the surgical radicality did not significantly influence the survival chances of @entity0 , however, with the increase in the @entity2 size the survival chance significantly decreases (p = 0.03). When predicting life expectancy, however, the stage of @entity2 , the age of @entity0 , the risk group and the M stage yielded essential information. At the age of 8 years and less, the rate of survivors is 67.6%, for those over 8 years is 75.9% (p = 0.21), however the younger age was not significant. The appearance of @entity1 considerably deteriorates the chances of survival (from 81.5% to 66.7%, p = 0.02). In the low risk group of @entity0 the 5-year survival is 80%, while in the high risk group it is significantly lower, 67.4% (p = 0.04).

title: Postoperative radiotherapy of XXXX .

answer: @entity3


abstract: Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The @entity0 (TCGA), The Encyclopedia of DNA Elements (ENCODE), and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap). These projects have provided unprecedented opportunities to interrogate the epigenome of @entity0 cell lines as well as normal and @entity0 tissues with high genomic resolution. The Bioconductor project offers more than 1,000 open-source software and statistical packages to analyze high-throughput genomic data. However, most packages are designed for specific data types (e.g. expression, epigenetics, genomics) and there is no one comprehensive tool that provides a complete integrative analysis of the resources and data provided by all three public projects. A need to create an integration of these different analyses was recently proposed. In this workflow, we provide a series of biologically focused integrative analyses of different molecular data. We describe how to download, process and prepare TCGA data and by harnessing several key Bioconductor packages, we describe how to extract biologically meaningful genomic and epigenomic data. Using Roadmap and ENCODE data, we provide a work plan to identify biologically relevant functional epigenomic elements associated with @entity0 . To illustrate our workflow, we analyzed two types of @entity3 : @entity1 ( @entity1 ) versus high-grade @entity1 ( @entity2 multiform or @entity1 ). This workflow introduces the following Bioconductor packages: AnnotationHub, ChIPSeeker, ComplexHeatmap, pathview, ELMER, GAIA, MINET, RTCGAToolbox,   TCGAbiolinks.

title: TCGA Workflow: Analyze XXXX genomics and epigenomics data using Bioconductor packages.

answer: @entity0


abstract: The objective of this study was to determine the forage:concentrate ratio that would provide the greatest duodenal flow of @entity2 in ewes supplemented with @entity1 oil and to determine how diets differing in forage content affect flow of conjugated @entity5 (CLA) and @entity7 (18:1(trans-11)). Five mature ewes (66.5 +/- 12.8 kg) fitted with ruminal and duodenal cannulas were used in a 5 x 5 Latin square experiment. Diets were isonitrogenous and included bromegrass hay, cracked @entity4 , @entity4 gluten meal, @entity0 , and limestone. Dietary fat was adjusted to 6% with @entity1 oil. Five ratios of forage:concentrate (18.4:81.6, 32.2:67.8, 45.8:54.2, 59.4:40.6, and 72.9:27.1) were fed at 1.3% of BW daily in equal allotments at 0630 and 1830. After 14 d, @entity6 (2.5 g) was dosed at each feeding for 7 d and ruminal, duodenal, and fecal collections were taken for the next 3 d. Duodenal flow of 18:0 increased linearly (P < 0.01) with dietary forage. Duodenal flow of 18:1(cis-9) and 18:2(cis-9,12) decreased (P < 0.001) but duodenal flow of 18:3(cis-9,12,15) increased (P < 0.01) with increased dietary forage. Biohydrogenation of dietary @entity2 increased (P < 0.001) as dietary forage increased, which was concomitant with increased ruminal pH. Duodenal flow of 18:2(cis-9,trans-11) increased linearly (P < 0.01) with increased dietary forage but increased abruptly when forage was fed at 45.8%. Duodenal flow of the trans-10, cis-12 and cis-10, cis-12 CLA isomers decreased as dietary forage increased, but flow tended to increase on the highest-forage diet, resulting in both linear (P < 0.01) and quadratic (P < 0.01) effects. Duodenal flow of 18:1(trans-11) decreased from 8.28 g/d on the 18.4% forage diet to 5.47 g/d on the 59.4% forage diet then increased to 7.29 g/d on the highest-forage diet (quadratic, P < 0.1). Duodenal flow of 18:1(trans-11) was 27- to 69-fold greater than flow of CLA. We conclude that when ewes were fed a 6% crude fat diet duodenal flows of dietary @entity3 changed incrementally as dietary forage was increased, whereas changes in flows of CLA isomers seemed to be more abrupt. Biohydrogenation changes were gradual with diet, suggesting a gradual shift in ruminal microbial populations with increasing forage. Finally, the highest-concentrate diet supported the greatest duodenal flows of dietary @entity2 , as well as the highest flow of 18:1(trans-11).

title: Effect of forage:concentrate ratio on ruminal digestion and duodenal flow of XXXX in ewes.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) is characterised by functional impairment, @entity1 , and degeneration of specific neuronal populations, especially pyramidal neurones of the cerebral cortex and hippocampal formation. Although @entity0 with @entity6 have been shown to have similar metabolic and volumetric deficits to those with @entity2 , the underlying pathogenesis of these changes is poorly understood. OBJECTIVE: To determine whether pyramidal cell loss occurs in @entity8 ( @entity8 ) @entity3 by quantifying hippocampal volume and @entity7 neurone number. METHODS: Fifty four prospectively studied @entity0 with @entity3 were screened, and four @entity0 fulfilling criteria for @entity8 with no other significant @entity5 were identified. These were compared with five @entity0 fulfilling criteria for @entity2 and seven controls matched for age and sex. The hippocampal formation was serially sectioned, and the number of @entity7 pyramidal neurones estimated using the optical dissector technique. Analysis of variance was used to evaluate group differences. RESULTS: @entity0 in both the @entity2 and @entity8 groups showed a substantial loss of pyramidal neurones from the @entity7 region. The pattern of hippocampal @entity1 and the degree of @entity7 @entity4 were similar in the two @entity3 groups. CONCLUSIONS: These findings support recent in vivo studies showing similar metabolic deficits and @entity1 in @entity2 and @entity6 . In addition, they provide evidence that the underlying cause of these abnormalities is a similar loss of neurones. Whereas the cause of the @entity4 in @entity2 is related to the deposition of abnormal proteins, the cause in @entity8 is unknown. In the absence of other pathologies, damage to cerebral microvasculature should be considered a likely candidate.

title: @entity0 with @entity6 due to microvascular pathology have significant hippocampal XXXX .

answer: @entity4