abstract: The results of transsphenoidal surgery as initial therapy for @entity8 in 57 acromegalic @entity0 were analyzed retrospectively. @entity0 with prior surgery or radiation therapy were excluded from the study. Three different criteria were used to define remission: @entity3 -suppressed (nadir) GH less than 1.0 microg/liter, a normal sex- and age-adjusted @entity4 level, and postoperative random GH levels of 2.5 microg/liter or less. Additionally, we analyzed the neuropathological data, including immunohistochemistry and ultrastructural categorization, and the surgical complications. The short-term remission rate (6-wk postoperative follow-up visit), as determined by a random GH measurement of 2.5 microg/liter or less, was 48.8%; the remission rate, as determined by nadir GH, was 51.4%. For 57 @entity0 followed for 12 months or more after surgery (mean, 37.7 months), surgical remission was achieved in 70.2%, 66.7%, and 61.1%, respectively, for @entity0 assessed by normal @entity4 , random GH, and nadir GH. One @entity0 (1.1%) developed recurrence of active @entity6 81 months after initially successful surgical therapy. Extrasellar growth of the @entity1 (P = 0.04) and dural invasion by the @entity5 (P = 0.008) were significant univariate predictors of a poor outcome. @entity1 size was significantly greater in @entity0 with persistent or recurrent @entity6 (P = 0.02). @entity0 with @entity1 of the ultrastructural categories of mixed GH/PRL cell and mammosomatotroph @entity5 had the lowest remission rates (50% and 42.9%, respectively). There were no perioperative @entity2 , and there was no serious morbidity. The permanent complication rate was 3.3% (1 permanent @entity7 and 2 nasal septal perforations). Surgical management of @entity6 currently provides prompt, effective, and satisfactory initial treatment for the majority of @entity0 . Using stringent criteria for remission, primary transsphenoidal surgery for @entity8 is effective and often definitive therapy for @entity6 . These results provide a benchmark for the contemporary results of surgical management as assessed by modern outcome criteria.

title: Surgical management of XXXX : an outcome study using modern remission criteria.

answer: @entity8


abstract: STUDY OBJECTIVE: There is little evidence that cardiopulmonary resuscitation (CPR) alone may lead to the resuscitation of @entity2 victims with other than respiratory causes (eg, pediatric arrest, drowning, @entity3 ). The objective of this study was to identify out-of-hospital @entity2 or advanced cardiac life support. METHODS: This observational cohort included all adult survivors of out-of-hospital @entity2 of a cardiac cause from phases I and II of the Ontario Prehospital Advanced Life Support Study. During the study period, the system provided a basic life support/defibrillation level of care but no advanced life support. CPR-only @entity0 were @entity0 determined to be without vital signs by EMS personnel who regained a palpable pulse in the field with precordial thump or CPR only and then were admitted alive to the hospital. Six members of a 7-member expert review panel had to rate the @entity0 as either probably or definitely having an out-of-hospital @entity2 , and a rhythm strip consistent with a @entity2 had to be present to be considered a @entity0 . Criteria considered were witness status, citizen or first responder CPR, CPR duration, arrest rhythm and rate, and performance of precordial thump. RESULTS: From January 1, 1991, to June 30, 1997, 9,667 @entity0 with out-of-hospital @entity2 were treated. The overall survival rate to hospital discharge was 4.6%. There were 97 apparent CPR-only @entity0 admitted to the hospital. Application of the inclusion criteria yielded 24 CPR-only @entity0 who had true out-of-hospital @entity2 and 73 @entity0 judged not to have @entity2 . Of the 24 true CPR-only @entity0 admitted to the hospital, 15 @entity0 were discharged alive, 10 @entity0 were witnessed by bystanders, and 7 @entity0 were witnessed by EMS personnel. The initial arrest rhythm was pulseless electrical activity in 9 @entity0 , @entity2 in 12 @entity0 , and @entity1 in 3 @entity0 . One @entity0 with @entity1 converted to @entity4 with a single precordial thump. CONCLUSION: CPR-only survivors of true out-of-hospital @entity2 do exist; some victims of out-of-hospital @entity2 of primary cardiac cause can survive after provision of out-of-hospital basic life support care only. However, many @entity0 found to be pulseless by means of out-of-hospital evaluation likely did not have a true @entity2 . This has implications for the survival rates of most, if not all, previous @entity2 reports. Survival rates from @entity2 may actually be lower if one excludes survivors who never had a true arrest. The absence of vital signs by out-of-hospital assessment alone is not adequate to include @entity0 in research reports or quality evaluations for @entity2 .

title: CPR-only survivors of out-of-hospital XXXX : implications for out-of-hospital care and @entity2 research methodology.

answer: @entity2


abstract: BACKGROUND: The extraordinary invasive capability is a major cause of treatment failure and @entity1 recurrence in @entity0 . Evidence in other cell systems has implicated the regulatory role of microRNA-145 in cell motility and invasion, which promotes us to investigate the biological functions of @entity3 in @entity0 in this regard. RESULTS: We have found that @entity3 is dramatically down-regulated in clinical specimen of @entity0 and is negatively correlated with the @entity1 pathological grading in the current study. The cells transfected by @entity3 expression vector have demonstrated retarded cell mobility. Using a bioinformatics analysis approach, @entity5 ( @entity5 ), actin-binding protein, has been identified as the target of @entity3 . Over-expression of @entity3 mimics enhanced protein levels of @entity4 and fibronectin, indicative of its inhibitory role in @entity2 occurrence. Mechanistic studies showed that @entity3 mimics inhibited @entity5 expression and @entity3 inhibitor enhanced it. Over-expression of @entity5 reversed @entity3 -regulated expression of @entity2 markers, suggesting that @entity5 mediated the inhibitory effects of @entity3 . Our results revealed a novel mechanism that @entity3 inhibits @entity0 cells migration and invasion via @entity5 downregulation. CONCLUSIONS: These results suggest that @entity3 may function as anti-migration and anti-invasion influence in @entity0 and provides a potential approach for developing @entity3 -based therapeutic strategies for @entity0 therapy.

title: MicroRNA-145 inhibits migration and invasion by down-regulating XXXX in @entity0 .

answer: @entity5


abstract: OBJECTIVES: Recent experimental evidence suggests that @entity3 channel blockers (CCBs) may have anti-fibrotic effects on liver and @entity8 . We aimed to investigate whether use of CCBs was associated with the skin @entity2 in @entity0 with @entity5 ( @entity5 ). METHODS: Based on the 5-year follow-up data from the Canadian @entity7 Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin @entity2 measured by the modified Rodnan skin score (mRSS). We also used GEE models to explore the associations between use of CCBs and risk of secondary outcomes including @entity6 , @entity8 , @entity4 , and @entity1 . RESULTS: There were 1547 @entity0 (1330 females) with @entity5 included in this study. Their mean age was 55.5 years and there were 606 @entity0 taking CCBs at baseline. No significant difference in mRSS between the use versus non-use of CCBs was found in the multivariable analysis: mean difference = -0.19 (95% confidence interval: -0.62, 0.23), p-value = 0.37. Use of CCBs was not significantly related to risk of secondary outcomes, with an odds ratio (OR) of 1.13 for @entity6 , 0.94 for @entity8 , 0.90 for @entity4 and 1.69 for @entity1 , respectively. CONCLUSIONS: No significant associations between use of CCBs and skin @entity2 , @entity6 , @entity8 , @entity4 and @entity1 were found in @entity0 with @entity5 . More evidence from other well-designed studies would be required to confirm these findings.

title: Relationship between @entity3 channel blockers and skin @entity2 in XXXX with @entity5 .

answer: @entity0


abstract: AIMS: Sustentacular cells are found in approximately half of @entity2 . However, most studies of sustentacular cells have used the less-specific antibody to the @entity3 protein, and any correlation between the presence of sustentacular cells and other clinicopathological factors is unclear. The aim of this study was to analyse the significance of sustentacular cells in @entity0 (NECs). METHODS AND RESULTS: A @entity5 antibody was used to investigate 113 pulmonary NECs. Sustentacular cells were observed in 66.7% of @entity4 ( @entity4 ) and 58.3% of @entity4 ( @entity4 ) cases, but not in high-grade NECs. @entity2 had a statistically significant correlation with peripheral locations. We found no statistical differences in age, gender, smoking history, overall survival, or the occurrence of lymph node @entity1 . In all but one case, when sustentacular cells were present in the primary site, they were also present in the metastatic lymph nodes. The presence of sustentacular cells differed in morphological subtypes, with the spindle pattern being the most common subtype. CONCLUSIONS: @entity5 -positive sustentacular cells were observed in @entity2 but not in high-grade NECs. Sustentacular-rich @entity2 did not show a correlation with the occurrence of lymph node @entity1 or survival. The sustentacular cells found differed in morphological subtypes.

title: @entity5 -positive sustentacular cells in neuroendocrine XXXX .

answer: @entity0


abstract: Endotracheal intubation is a lifesaving technique performed by flight crews often under difficult circumstances. Inadvertent unrecognized esophageal intubation is reported to occur up to 8% of the time. Recently a new disposable device has been developed to assist in determining proper endotracheal tube placement. The FEF end-tidal @entity2 detector (Fenem Co.) was evaluated in this study. From June 1989 to January 1990, all @entity0 intubated or transported with endotracheal tubes in place by LifeStar, helicopter Emergency Medical Service, had the FEF detector positioned on the endotracheal tube. Flight crews continuously monitored changes in the indicator of the FEF during transport. On arrival to the emergency department, tube position was verified with direct laryngoscopy by an emergency department physician or @entity1 surgeon. Thirty-five @entity0 were entered into the study. Thirty-four were identified by direct laryngoscopy as having proper placement of the their endotracheal tube and one was found to be intubated in the esophagus. The FEF device properly identified the single esophageal intubation and accurately identified proper position of the endotracheal tube in thirty-two @entity0 . Of the three @entity0 in @entity3 , the FEF device was accurate in detecting tube position in each case. The overall sensitivity of the FEF detector in this aeromedical setting was 94%. Specificity was calculated as 100%. The overall positive predictive value of the FEF detector was 100%. We therefore conclude that indication of a tracheal intubation by the FEF detector is reliable after six breaths in the aeromedical setting and advocate its use as an adjunct for monitoring tube position while in flight.

title: Evaluation of an end-tidal XXXX detector in the aeromedical setting.

answer: @entity2


abstract: A clinical study was carried out to assess the response of 46 @entity0 to oral loads of @entity6 after recovery from severe @entity1 . The response was measured by the increases in blood reducing @entity6 and by the variations in the stool pattern following administration of oral @entity6 . @entity7 oral loads were used in the test. During the acute stage of the illness, 38 of the 46 @entity0 had exhibited intolerance to @entity6 , as evidenced by the excretion of acid stools and/or stools with a greater than .25% @entity5 content. Prompt improvement from @entity1 was induced by elimination of all @entity4 , @entity8 , and other @entity6 from the diet. None of the @entity0 had monosaccharide intolerance during the acute diarrheal stage. The @entity5 oral loads were administered within 1 week after recovery and serially thereafter. Responses to @entity3 and @entity4 loads were related to the degree of intolerance exhibited during the illness. In @entity0 with @entity1 , the impaired @entity5 metabolism is temporary. Oral feedings may be administered after cessation of profuse @entity1 and @entity2 and after replacement of water and electrolytes. @entity0 should be back on a milk formula within 3-4 months, depending on the degree of @entity5 intolerance exhibited during the illness.

title: The response of XXXX to @entity5 oral loads after recovery from @entity1 .

answer: @entity0


abstract: The relation between myocardial functional changes and the apoptosis-related proteins in @entity0 with @entity1 ( @entity1 ) has not yet been reported. The purpose of this study was to assess this issue through the use of @entity2 stress echocardiography. A total of 81 segments of left ventricles (from 6 @entity0 with @entity1 ) were collected in this study. Segments from another 5 @entity0 who had died of noncardiac causes were used as the control. Apoptosis-related proteins ( @entity4 , @entity3 , and @entity5 ) and apoptosis were evaluated in these segments by immunocytochemical stain and terminal deoxynucleotidyl transferase-mediated DNA nick end-labeling assay. There were 26 segments with @entity2 -induced contractile reserve. There were significant differences in numbers of segments with overexpression of @entity3 and @entity4 in the study and control groups. However, @entity5 was not found in either group. The total terminal deoxynucleotidyl transferase-mediated DNA nick end-labeling-positive nuclei in explanted hearts of @entity1 was 0.73%. The myocardial contractile reserve was inversely associated with an overexpression of @entity3 (P <.01) rather than @entity4 . In conclusion, the expression of @entity4 and @entity3 proteins in @entity0 with @entity1 is enhanced and independent of @entity5 . Loss of contractile reserve is associated with overexpression of @entity3 protein in failing myocardium.

title: The correlation between expression of apoptosis-related proteins and myocardial functional reserve evaluated by XXXX stress echocardiography in @entity0 with @entity1 .

answer: @entity2


abstract: OBJECTIVE: This study was to evaluate the efficacy of percutaneous vertebroplasty (PVP) in treating vertebral metastases, focusing on the related intractable @entity2 and operative complications including cement leakage, @entity3 , dysneuria, etc. @entity0 AND METHODS: Forty-seven @entity0 with spinal @entity1 who underwent PVP between September 2011 and March 2013 in the hospital were evaluated retrospectively. @entity2 scores on one day before the surgery, on one day after the surgery and at the end of the follow-up were recorded using VAS. The VAS scores were analyzed by Wilcoxon rank-sum test using SPSS 19.0. The distribution and leakage of @entity5 and complications ( @entity3 , dysneuria, etc.) were evaluated by CT and plain film. RESULTS: PVP in all @entity0 was successful. The preoperative mean value of VAS and the postoperative mean value of VAS showed statistical difference (8.4  1.4 and 3.1  2.3 respectively). At the end of follow-up, the mean value of VAS was 3.4  1.9. Bone cement leakage was observed in 35 vertebrae. Among the cases with bone cement leakage, one case showed the related complication (radiating @entity2 in left limb) and was relieved after treatment of @entity4 and analgesia for one week; the others did not present any related complication. CONCLUSION: With some limitations in the study, PVP appeared to be an alternative method to treat painful spine metastases.

title: Efficacy of percutaneous vertebroplasty in XXXX with painful vertebral metastases: A retrospective study in 47 cases.

answer: @entity0


abstract: The objective of this study was to evaluate the value of bronchoalveolar lavage (BAL) and postbronchoscopic sputum cytology in diagnosing peripheral @entity1 . We performed a prospective study in 55 @entity0 with lesions on chest radiographs who were suspected of having @entity1 and had non-endoscopically visible lesions on fiberoptic bronchoscopy. The sequence of procedures in all cases was BAL and transbronchial forceps biopsy. The final diagnosis of these @entity0 were @entity1 in 30 @entity0 , metatastic @entity1 in five and benign diseases in 20. In the @entity1 group, BAL was positive for malignant cells in 14 of the 30 @entity0 (46.7%). In seven (50%) of these @entity0 , the cell type diagnosed by BAL agreed with the final diagnosis. The diagnostic yield of BAL was influenced by the size and segmental location of the lesion. Bronchoalveolar lavage provided a higher diagnostic yield (46.7%) than transbronchial biopsy (16.7%). In five @entity0 with @entity1 and 20 @entity0 with benign disease, BAL gave negative results in all. Postbronchoscopic sputum cytology was positive in only two of the 26 @entity0 (7.7%) from whom samples could be obtained. Bronchoalveolar lavage cytology proved to be a valuable diagnostic tool in detecting peripheral, @entity1 . Postbronchoscopic sputum cytology provided no significant additional information.

title: Diagnostic value of bronchoalveolar lavage and postbronchoscopic sputum cytology in peripheral XXXX .

answer: @entity1


abstract: UNASSIGNED: Successful breast conserving surgery consists of complete removal of the @entity2 while sparing healthy surrounding tissue. Despite currently available imaging and margin assessment tools, recognizing @entity2 tissue at a resection margin during surgery is challenging. @entity3 ( @entity3 ), which uses light for tissue characterization, can potentially guide surgeons to prevent @entity2 positive margins. However, inter- @entity1 variation and changes in tissue physiology occurring during the resection might hamper this light-based technology. Here we investigate how inter- @entity1 variation and tissue status (in vivo vs ex vivo) affect the performance of the @entity3 optical parameters. In vivo and ex vivo measurements of 45 @entity0 @entity1 were obtained and quantified with an analytical model to acquire the optical parameters. The optical parameter representing the ratio between fat and water provided the best discrimination between normal and @entity2 tissue, with an area under the receiver operating characteristic curve of 0.94. There was no substantial influence of other @entity1 factors such as menopausal status on optical measurements. Contrary to expectations, normalization of the optical parameters did not improve the discriminative power. Furthermore, measurements taken in vivo were not significantly different from the measurements taken ex vivo. These findings indicate that @entity3 is a robust technology for the detection of @entity2 tissue during breast conserving surgery.

title: Using @entity3 during breast conserving surgery: identifying robust optical parameters and influence of inter- XXXX variation.

answer: @entity1


abstract: AIM: The aims of this study were to: 1) ascertain if @entity4 resin in 0.5% [PE(0.5%)] and 0.25% [PE(0.25%)] in @entity2 (PE) self-applied sequentially for 3 days with 4 days break cycle is as effective as supervised @entity4 25% in tincture @entity5 (PB) applied in the clinic biweekly in treating penile warts and 2) ascertain if PE causes less skin irritation than PB. METHODS AND RESULTS: The clearance rate of penile warts was 36.4% (4/11) in PE (0.5%) treated group, 66.7% (4/6) in the PE (0.25%) treated group and 33.3% (6/18) for PB treated group after 1 week (ns). The wart clearance rate at 6 weeks for PE (0.5%) treated group, PE (0.25%) treated group and PB treated group were 81.8% (9/11), 100% (6/6) and 83.3% (15/17) respectively (ns). There were 47 individual warts on the penis of the 17 @entity0 in the PE treated group and 58 individual warts on the penis of the 18 @entity0 in the PB treated group. Based on the response of individual warts to the 2 treatment regimens, the clearance rate was 42.6% (20/47) for the PE treated group and 25% (15/56) for the PB treated group after 1 week treatment (ns). At 6 weeks follow-up, the clearance rate for the PE treated group and the PB treated group were 85.1% (40/47) and 73.2% (41/56) respectively (ns). Skin irritation including superficial @entity3 , @entity1 and itch were observed in 47% (8/17) in @entity0 treated with PE compared to 38.9% (7/18) in @entity0 treated with PB (ns) during the 6 weeks follow-up period. The clearance rate of @entity0 treated with PE (0.25%) was compared to those treated with PE (0.5%). Four out of six of PE (0.25%) treated @entity0 had clearance of warts after 1 week and 100% clearance at the end of 6 weeks. None experienced any skin irritation. CONCLUSION: This study demonstrates that 0.5% @entity4 (and possibly 0.25% @entity4 ) in @entity2 is effective in eradicating penile warts. It can be used by @entity0 for self-treatment at home with greater convenience and is more cost effective than the conventional @entity4 25% in tincture benzoin paint.

title: Comparing treatment response and complications between @entity4 0.5%/0.25% in @entity2 vs XXXX 25% in tincture benzoin for penile warts.

answer: @entity4


abstract: OBJECTIVES: We investigated the association of impaired blood polymorphonuclear leukocyte (PMN) migration with the incidence of @entity4 in @entity0 with severe @entity2 . METHOD: Twenty-six intensive-care @entity0 with different injury severity scores were enrolled in a prospective study. PMN migration was measured daily using 300 microl fresh whole blood in a membrane filter assay. Migration was evaluated in an automated image analyzer that recorded numbers and distribution of the immigrant PMNs within a filter. The relevant parameter was the percentage of PMNs that migrated from the blood samples into the filters upon @entity5 stimulation. RESULTS: Nine @entity0 developed posttraumatic @entity3 verified microbiologically. These @entity0 showed a reduced PMN migratory capacity in comparison with the 17 @entity0 without @entity3 . A migrating portion of six per cent or less at least three days in succession preceded @entity3 by one to 19 days and indicated @entity3 in eight true positive versus three false positive cases, and 14 true negative versus one false negative case, i.e. specificity was 82.3% and sensitivity 88.8%, p=0.0008. @entity2 severity had no influence on PMN migration. CONCLUSIONS: @entity2 @entity0 with @entity1 are at risk for @entity4 . Whole-blood migration tests can define the @entity3 risk and thus may be useful predictive markers for @entity3 .

title: Impaired blood polymorphonuclear leukocyte migration and XXXX risk in severe @entity2 .

answer: @entity3


abstract: BACKGROUND: Elevated fasting levels of branched chain @entity4 (BCAAs: @entity5 , @entity6 , @entity1 ) in venous blood are associated with a variety of @entity0 , including increased risk of @entity3 ( @entity3 ). Fasting @entity7 levels are influenced by non-dietary factors. However, it is unknown whether fasting BCAAs can be altered through manipulation of dietary intake alone. OBJECTIVE: To test whether a specific dietary intervention, using differences in @entity7 intake, alters fasting @entity7 levels independent of other factors. DESIGN: Five healthy male volunteers underwent 4 days of a low and 4 days of a high @entity7 content dietary intervention (ClinicalTrials.gov [NCT02110602]). All food and supplements were provided. Fasting BCAAs were measured from venous blood samples by mass spectrometry at baseline and after each intervention. RESULTS: Diets were isocaloric; contained equal percentages of calories from @entity2 , fats, and protein; and differed from each other in @entity7 content (1.5  0.1 vs. 14.0  0.6 g for @entity5 ; 4.5  0.9 g vs. 13.8  0.5 g for @entity6 ; 2.1  0.2 g vs. 27.1  1.0 g for @entity1 ; p<0.0001 for all). Fasting @entity5 was significantly lower (p=0.02) and fasting @entity6 and @entity1 were numerically lower following the low @entity7 content vs. the high @entity7 content diet levels. The inter-individual response to the dietary interventions was variable and not explained by adherence. CONCLUSION: Short-term dietary manipulation of @entity7 intake led to modest changes in fasting levels of BCAAs. The approach from our pilot study can be expanded to test the metabolic implications of dietary @entity7 manipulation.

title: A pilot, short-term dietary manipulation of branched chain @entity4 has modest influence on fasting levels of branched chain XXXX .

answer: @entity4


abstract: OBJECTIVE: @entity0 who have abortions are at high risk of contraception discontinuation and subsequent unintended pregnancy. The objective of this analysis was to identify factors associated with choice of highly effective long-acting, @entity1 -only contraceptive methods after abortion. STUDY DESIGN: @entity0 presenting for surgical abortion who selected the @entity2 @entity6 , the @entity1 implant, or the @entity1 injection (depot @entity3 , or @entity4 ) as their post-abortion contraceptives were recruited to participate in a one-year prospective cohort study. We used multivariable multinomial logistic regression to identify factors associated with choosing long-acting, reversible contraceptives ( @entity6 or implant) compared to @entity4 . RESULTS: A total of 260 @entity0 , aged 18-45 years, enrolled in the study, 100 of whom chose the @entity6 , 63 the implant, and 97 @entity4 . The @entity0 were 24.9 years old on average; 36% were black and 29% were Latina. Fifty-nine percent had had a previous abortion, 66% a prior birth, and 55% were undergoing a second-trimester abortion. In multivariable analyses, compared with @entity4 users, @entity0 who chose the @entity6 or the implant were less likely to be currently experiencing intimate partner violence (IPV,) reported higher stress levels, weighed more, were more likely to have finished high school, to have used the pill before, and to report that counselors or doctors were helpful in making the decision (all significant at p<0.05, see text for relative risk ratios and confidence intervals.) In addition, @entity0 who chose the @entity6 were less likely to be black (p<0.01,) and @entity0 who chose the implant were more likely to report that they would be unhappy to become pregnant within 6 months (p<0.05,) than @entity4 users. CONCLUSION: A variety of factors including race/ethnicity, past contraceptive use, feelings towards pregnancy, stress and weight were different between @entity5 and @entity4 users. Notably, current IPV was associated with choice of @entity4 over the @entity6 or implant, implying that a desire to choose a hidden method may be important to some @entity0 and should be included in counseling. IMPLICATIONS: In contraceptive counseling, after screening for intimate partner violence, assessing @entity0 's stress, and taking a history about past contraceptive use, clinicians should discuss whether these factors might affect a @entity0 's choice of method.

title: Choice of the XXXX intrauterine device, etonogestrel implant or depot @entity3 for contraception after aspiration abortion.

answer: @entity2


abstract: @entity5 ( @entity5 ) has a rapidly fatal clinical course, being resistant to multimodal treatments. Microtubules, a/b tubulin heterodimers, are crucial in cell signaling, division and mitosis and are among the most successful targets for anticancer therapy. Panobinostat ( @entity7 ) is a potent deacetylase inhibitor acting both on histones and nonhistonic proteins, including a-tubulin. In vitro @entity7 , evaluated in three @entity5 cell lines (BHT-101, CAL-62 and 8305C), resulted in impairment of cell viability, inhibition of colony formation, cell cycle arrest and apoptosis induction. Mechanistically, we showed that @entity7 not only affected the expression of @entity4 and @entity6 , but markedly determined microtubule stabilization as evidenced by tubulin acetylation and increased tubulin polymerization. In a @entity3 xenograft model implanted with @entity0 cells, the cytotoxic properties of @entity7 were confirmed. The drug at the dose of 20 mg/kg significantly impaired @entity1 growth ( @entity1 .5-fold smaller than in untreated animals); at this dose, no relevant side effects were observed. In @entity1 of treated animals, a significant reduction of Ki67, which was negatively correlated with tubulin acetylation, was observed. Moreover, @entity8 -tubulin levels negatively correlated with @entity1 volume at sacrifice, reinforcing the opinion that tubulin acetylation has a role in the inhibition of @entity1 growth. In conclusion, @entity7 , acting on both histones and nonhistonic proteins in @entity2 , appears to be a promising therapeutic agent for the treatment of this kind of @entity1 which is known not to respond to conventional therapy.

title: Cytotoxic activity of the histone deacetylase inhibitor panobinostat ( @entity7 ) in XXXX in vitro and in vivo.

answer: @entity2


abstract: PURPOSE: To study the possible association between clear corneal incision with or without placement of a suture during @entity2 extraction and @entity1 . DESIGN: Retrospective, comparative, case-controlled study. METHODS: Thirty-eight @entity0 treated for culture-positive, acute post- @entity2 surgery @entity3 , and 371 randomly selected control @entity0 who underwent uncomplicated @entity2 surgery in the referring community were studied. Incision type and use of suture during @entity2 surgery of @entity3 @entity0 were compared with the controls. The data were analyzed using logistic regression methods. RESULTS: Of the 38 @entity0 with @entity3 , 17 @entity0 (45%) had clear corneal incisions and 21 @entity0 (55%) had a scleral tunnel incision. In 371 controls, 76 @entity0 (20%) had clear corneal incisions and 295 @entity0 (80%) had scleral tunnel incisions. Clear corneal incision was associated with a threefold greater risk of @entity3 than was scleral tunnel incision (Odds Ratio, 3.36, 95% Confidence Interval = 1.67 to 6.78). The type of incision was significant (chi(2) = 11.53, P =.0007); a clear corneal incision was more frequently associated with @entity3 . A subgroup analysis revealed that the presence or absence of a suture was not significant (chi(2) = 1.31, P =.2524). CONCLUSIONS: In this retrospective, case-controlled study, clear corneal incisions were found to be a statistically significant risk factor for acute post- @entity2 surgery @entity3 when compared with scleral tunnel incisions.

title: Case-control study of XXXX after @entity2 surgery comparing scleral tunnel and clear corneal wounds.

answer: @entity3


abstract: AIM: Energy restricted meal plans may compromise nutrient intake. This study used diet modelling to assess the nutritional adequacy of energy restricted meal plans designed for weight management in young @entity1 @entity0 . METHODS: Diet modelling of 6000 kJ/d animal protein based meal plans was performed using Australian nutrient databases with adequacy compared to the Australian Nutrient Reference Values (NRVs) for @entity0 (19-30 years). One diet plan was based on the higher @entity4 (HC) version of the Australian Guide to Healthy Eating for @entity0 19-60 years. An alternative higher protein (HP) plan was adapted from the CSIRO Total Wellbeing Diet. Vegan and lacto-ovo versions of these plans were also modelled and compared to the appropriate vegetarian NRVs. RESULTS: Both animal protein diets met the estimated average requirement (EAR) or adequate intake (AI) for all nutrients analysed. The recommended dietary intake (RDI) was also satisfied, except for @entity2 . HC met 75  30% and HP 81  31% of the @entity2 RDI when red meat and @entity2 fortified cereal were both included three days a week, and remained below the RDI even when red meat was increased to seven days. @entity2 for the modified vegan (57  5% HC; 66  4% HP) and lacto-ovo (48  6% HC; 59  7% HP) plans was below the RDI and @entity3 below the EAR for the vegan (76  8% HC; 84  9% HP) plans. CONCLUSION: The 6000 kJ/d animal protein meal plans met the RDI for all nutrients except @entity2 . @entity2 and @entity3 failed to meet the vegetarian RDI and EAR respectively for the vegan plans.

title: Nutritional adequacy of energy restricted diets for young XXXX @entity0 .

answer: @entity1


abstract: @entity1 receptor (NR) activation in the hippocampus and neocortex plays a central role in memory and cognitive function. We analyzed the cellular expression of the five NR subunit ( @entity4 and @entity5 -D) mRNAs in these regions with in situ hybridization and @entity0 ribonucleotide probes. Film autoradiograms demonstrated a distinct pattern of hybridization signal in the hippocampal complex and the neocortex with probes for @entity4 , @entity5 , and @entity6 mRNA. @entity8 and @entity7 probes yielded scattered signals without a distinct organization. At the emulsion level, the @entity4 probe produced high-density hybridization signals across the hippocampal complex. @entity5 mRNA was higher in dentate granule cells and pyramidal cells in @entity2 and subiculum compared to hilus neurons. @entity6 mRNA expression was moderate throughout, with higher expression in dentate granule cells, @entity2 and @entity3 pyramidal cells than in hilus neurons. In the hippocampal complex, the @entity8 probe signal was not different from background in any region, whereas the @entity7 probe signal resulted in low to moderate grain densities. We analyzed NR subunit mRNA expression in the prefrontal, parietal, primary visual, and motor cortices. All areas displayed strong @entity4 hybridization signals. @entity5 and @entity6 mRNAs were expressed in cortical areas and layers. @entity8 mRNA was expressed at low levels in distinct layers that differed by region and the @entity7 signal was equally moderate throughout all regions. Pyramidal cells in both hippocampus and neocortex express @entity4 , @entity5 , @entity6 , and, to a lesser extent, @entity7 mRNA. Interneurons or granular layer neurons and some glial cells express @entity8 mRNA.

title: Expression of XXXX receptor subunit mRNAs in the @entity0 brain: hippocampus and cortex.

answer: @entity1


abstract: UNASSIGNED: In previous studies, @entity3 @entity0 showed abnormalities in @entity1 -related evoked responses, as reduced @entity2 to repetitive stimulation. In this study, we aimed to apply a novel analysis of EEG bands synchronization and directed dynamical influences under @entity1 stimuli in @entity3 @entity0 compared to non- @entity3 healthy volunteers. Thirty-one @entity4 outpatients (MIGR) were evaluated and compared to 19 controls (CONT). The right hand was stimulated by means of 30 consecutive CO2 laser stimuli. EEG signal was examined by means of Morlet wavelet, @entity5 ( @entity5 ), and Granger causality (GC), and the statistically validated results were mapped on the corresponding scalp locations. The vertex complex of averaged laser-evoked responses (LEPs) showed reduced @entity2 compared to CONT. In the prestimulus phase, enhanced @entity5 in the 0, 5-30   Hz range was present in MIGR and CONT between the bilateral temporal-parietal and the frontal regions around the midline. @entity3 @entity0 showed an anticipation of EEG changes preceding the @entity1 stimulation compared to CONT. In the poststimulus phase, the same cortical areas were more connected in MIGR vs CONT. In both groups of @entity0 and CONT, the @entity2 index was negatively correlated with the GC scores. A different pattern of cortical activation after @entity1 stimulation was present in @entity3 . The increase in cortical connections during repetitive @entity1 stimulation may subtend the phenomenon of LEPs reduced @entity2 . Brain network analysis may give an aid in understanding subtle changes of @entity1 processing under laser stimuli in @entity3 @entity0 .

title: Functional Connectivity of EEG Signals Under Laser Stimulation in XXXX .

answer: @entity3


abstract: BACKGROUND: For school-aged @entity0 with reading difficulties, an emerging and important area of investigation concerns determining predictors of intervention response. Previous studies have focused exclusively on cognitive and broadly defined behavioral variables. What has been missing, however, are studies examining @entity1 , which is among the most commonly experienced difficulty for youth. OBJECTIVE: The present study examined @entity1 among @entity0 classified as typically achieving or showing inadequate/adequate response following an intervention for reading problems. METHODS: @entity0 were 153 ethnically-diverse @entity0 (84 male, 69 female) evaluated in the winter and spring of their first-grade academic year. @entity0 completed several standardized measures of reading achievement involving decoding and fluency along with a multidimensional @entity1 rating scale. RESULTS: Repeated measures ANOVA revealed significant main effects for time and scale and significant interactions for time*scale and group*scale. Logistic regression examined whether @entity1 predicted response to intervention (Y/N) at the end of the school-year. CONCLUSIONS: Results showed overall decreases in @entity1 over time, with the exception of the harm avoidance area which increased and also interacted with group ( @entity0 with decoding/fluency difficulties reported less harm avoidance than typically achieving @entity0 ). The harm avoidance area was most pertinent across analyses highlighting the potential importance of targeting this area; however, none of the @entity1 scales predicted response group at the end of the intervention. Ongoing research is needed in this area in order to identify characteristics of inadequate responders to reading intervention programs and/or inform interventions that incorporate these socioemotional factors.

title: XXXX and Response to Reading Intervention among First Grade Students.

answer: @entity1


abstract: PURPOSE: The aim of this study was to evaluate characteristics of @entity5 multiforme, effectiveness of treatment modalities, and detect factors related to outcome. METHODS: A detailed analysis was performed on a series of 15 @entity0 treated between 2000 and 2013, based on their clinical, radiologic, pathologic, treatment, and follow-up data. RESULTS: Median survival time of @entity0 with @entity5 was 13.5  months. One- and 2-year overall survival probabilities were 66.7 and 20  %, respectively. There were no significant differences in survival based on @entity0 ' gender, age, disease presentation with or without @entity3 , signs/symptoms of @entity4 , or @entity1 location. The presence of @entity2 initially, as well as prior to radiotherapy, which was quantified by neurologic function score (NFS), had an impact on overall survival. @entity0 with NFS 0 lived longer compared to others (p   =   0.001). Survival of @entity0 that underwent gross total resection was longer than that of @entity0 that underwent subtotal resection (p   =   0.030). Mean survival time of @entity0 with gross total resection was 73.5  months, compared to 13  months in @entity0 with subtotal resection. There was no significant correlation between outcome and type of radiotherapy. In four @entity0 with gigantocellular @entity5 , we found no evidence of a better prognosis. Two long-term survivors were recorded. Both of them underwent gross total resection and were assigned a NFS 0. CONCLUSIONS: Gross total resection is essential for longer overall survival among pediatric @entity0 with @entity5 and offers a possibility for long-term survival. Severity of neurologic symptoms quantified by NFS can be considered as a potential predictor of outcome.

title: XXXX : a single institution experience.

answer: @entity5


abstract: The numbers of reptiles in homes has at least doubled in the last decade in Europe and the USA. Reptile purchases are increasingly triggered by the attempt to avoid potentially allergenic fur pets like @entity2 and @entity3 . Consequently, reptiles are today regarded as surrogate pets initiating a closer relationship with the owner than ever previously observed. Reptile pets are mostly fed with insects, especially grasshoppers and/or locusts, which are sources for aggressive airborne allergens, best known from occupational insect breeder @entity5 . Exposure in homes thus introduces a new form of @entity5 to grasshoppers and related insects. Accordingly, an 8-year old @entity0 developed severe @entity1 and @entity4 within 4  months after purchase of a bearded dragon. The reptile was held in the living room and regularly fed with living grasshoppers. In the absence of a serological @entity5 diagnosis test, an IgE immunoblot on grasshopper extract and prick-to-prick test confirmed specific sensitization to grasshoppers. After 4  years of allergen avoidance, a single respiratory exposure was sufficient to trigger a severe @entity4 attack again in the @entity0 . Based on literature review and the clinical example we conclude that reptile keeping is associated with introducing potent insect allergens into home environments. @entity0 interviews during diagnostic procedure should therefore by default include the question about reptile pets in homes.

title: Caution: Reptile pets shuttle grasshopper @entity5 and XXXX into homes.

answer: @entity4


abstract: The chemosensitivity of micrometastases in the peritoneal cavity to a @entity5 derivative ( @entity6 ) was examined with a micrometastasis model featuring a @entity0 @entity4 cell line tagged with the green fluorescence protein (GFP) gene in @entity3 . Peritoneal metastases on the omentum and mesentery could be specifically visualized even when minute or dormant and also externally monitored noninvasively under illumination with blue light from 1 day after intraperitoneal (i.p.) injection of @entity2 cells. Metastatic deposits formed after i.p. injection of 2x10(6) @entity2 cells were significantly reduced by @entity6 in a dose-dependent manner (15-20 mg/kg), when it was orally administered from day 1 post-injection for 4 weeks (early administration). No such inhibition was evident after injection of 1x10(7) @entity2 cells. When 2x10(6) @entity2 cells given injection, the ascites-free period in @entity6 -treated @entity3 was significantly longer than in their untreated counterparts. Survival of @entity6 -treated @entity3 (5/15) was also significantly higher than the zero rate in controls (0/15), with 4 out of 5 surviving @entity3 being free from peritoneal @entity1 and the exception having only a few dormant metastases. In contrast, when @entity6 was administered starting from day 7 post-injection for 4 weeks (late administration), the survival and ascites-free period of the @entity6 -treated @entity3 were not significantly influenced. The results indicate that the chemosensitivity of peritoneal metastases to @entity6 is dependent on the number of i.p. @entity2 cells and the timing of drug administration. Peritoneal micrometastases at an early stage are most susceptible and can be effectively eliminated by oral administration of an anti- @entity2 agent, which leads to the longer survival and better quality of life (QOL) of the @entity3 .

title: Chemosensitivity of peritoneal micrometastases as evaluated using a green fluorescence protein (GFP)-tagged XXXX @entity4 cell line.

answer: @entity0


abstract: Development of a small animal model to study @entity2 healing has been challenging in the past. Stabilization of osteotomy in small animals has mainly been accomplished using Krishner wires. Krisheners offer stabilization, but can result in a significant increase in @entity2 . An alternative approach using a modified twenty-five hole 1.5 mm stainless steel plate was used to stabilize a 5 mm femoral osteotomy, and @entity2 stabilization was followed for a period of 15 weeks in adult male @entity0 . Fifty four of fifty-six animals (96%) were followed 15 weeks post operatively. Within the first few days post operatively, two animals showed evidence of fixation failure due to technical error, and the animals were humanely sacrificed. Otherwise, after two days post-operatively the remaining 54 animals were weight bearing. At 15 weeks post-operatively, the @entity2 was stable with little bone formation evident. Therefore, this technique can effectively be used to evaluate compounds which will enhance bone formation. The technique allows for stable fixation of the control with little callus formation and @entity1 . This model will allow for x-ray analysis to follow bone growth in relation to bone enhancing compounds.

title: Plating of XXXX femoral shaft osteotomies: report of a technique and preliminary results.

answer: @entity0


abstract: OBJECTIVE: The aim of this study was to examine risk factors for @entity2 and @entity3 in institutionalised elderly @entity0 . DESIGN: Six-year prospective cohort study. SETTING: Twenty nine of the 30 institutions for elderly @entity0 in Kitakyushu, Japan. SUBJECTS: Four hundred and eighteen of the 1,096 subjects who were dentate at the baseline examination. OUTCOME MEASURES: Factors that influenced @entity2 and @entity3 . RESULTS: In both sexes, older subjects had fewer remaining teeth at baseline. Males lost more teeth than females, and @entity3 was also more likely in males than in females. Stepwise multiple linear regression analysis showed that the number of teeth, number of @entity1 , @entity4 , and plaque index were significant predictors for the number of teeth lost. The incidence of @entity3 was higher in males than in females. Stepwise multiple logistic regression analysis revealed that poorer mental health status, fewer teeth, having deep periodontal pocket, and poorer oral hygiene status were independently associated with the six-year incidence of @entity3 . CONCLUSIONS: @entity2 in institutionalised elderly @entity0 in Japan is related to both poor oral health status and poor mental health status.

title: Risk factors for XXXX in the institutionalised elderly; a six-year cohort study.

answer: @entity2


abstract: INTRODUCTION: Most @entity0 with @entity1 are elderly and poorly represented in randomized clinical trials. They are often undertreated because of concerns about their ability to tolerate aggressive treatment. We tested the hypothesis that elderly @entity0 undergoing @entity4 might tolerate treatment differently than younger @entity0 . METHODS: A total of 125 @entity0 who underwent definitive lung radiotherapy were identified from a prospective institutional database (University of Michigan cohort). Logistic regression modeling was performed to assess the impact of age on @entity7 grade 2 or higher or grade 2 or higher and @entity2 grade 3 or higher or grade 2 or higher, with adjustment for esophageal and lung dose, respectively, as well as for chemotherapy utilization, smoking status, and performance status. The analysis was validated in a large cohort of 691 @entity0 from the Michigan Radiation Oncology Quality Consortium registry, an independent statewide prospective database. RESULTS: In the University of Michigan cohort, multivariable regression models revealed a significant inverse correlation between age and rate of @entity7 for both @entity3 levels, (adjusted OR  = 0.93 for both models and 95% confidence intervals of 0.88-0.98 and 0.87-0.99), with areas under the curve of 0.747 and 0.721, respectively, demonstrating good fit. This same association was noted in the Michigan Radiation Oncology Quality Consortium cohort. There was no significant association between age and @entity2 . CONCLUSIONS: There is a lower incidence of @entity7 with increasing age even after adjustment for use of chemotherapy. This is a novel finding in thoracic oncology. No age @entity5 was noted for @entity4 . The elderly are able to tolerate @entity6 well and should be offered this option when clinically warranted.

title: Lower Incidence of @entity7 in the Elderly Undergoing Definitive Radiation Therapy for XXXX .

answer: @entity1


abstract: BACKGROUND: Breathlessness, cough and @entity3 are distressing symptoms for @entity0 with @entity1 . There is evidence that these three symptoms form a discreet symptom cluster. This study aimed to feasibly test a new non-pharmacological intervention for the management of the Respiratory Distress Symptom @entity1 . METHOD: This was a multi-centre, randomised controlled non-blinded parallel group feasibility trial. Eligible @entity0 ( @entity0 with primary @entity1 and 'bothered' by at least two of the three cluster symptoms) received usual care plus a multicomponent intervention delivered over two intervention training sessions and a follow-up telephone call or usual care only. Follow-up was for 12  weeks, and end-points included six numerical rating scales for @entity4 severity, Dyspnoea-12, Manchester Cough in Lung Cancer scale, FACIT-Fatigue scale, Hospital Anxiety and @entity2 scale, Lung Cancer Symptom Scale and the EQ-5D-3L, collected at baseline, week 4 and week 12. RESULTS: One hundred seven @entity0 were randomised over 8  months; however, six were removed from further analysis due to protocol violations (intervention group n   =   50 and control group n   =   51). Of the ineligible @entity0 (n   =   608), 29  % reported either not experiencing two or more symptoms or not being 'bothered' by at least two symptoms. There was 29  % drop-out by week 4, and by week 12, a further two @entity0 in the control group were lost to follow-up. A sample size calculation indicated that 122 @entity0 per arm would be needed to detect a clinically important difference in the main outcome for @entity4 , cough and @entity3 . CONCLUSIONS: The study has provided evidence of the feasibility and acceptability of a new intervention in the @entity1 population and warrants a fully powered trial before we reach any conclusions. The follow-on trial will test the hypothesis that the intervention improves symptom cluster of @entity4 , cough and @entity3 better than usual care alone. Full economic evaluation will be conducted in the main trial.

title: Management of the respiratory distress symptom XXXX : a randomised controlled feasibility trial.

answer: @entity1


abstract: PURPOSE: @entity5 @entity6 ( @entity5 @entity6 ) @entity4 is a phenotypically diverse disease with symptoms ranging from predominant @entity1 to exclusive @entity2 . The aims of this study were to determine the dispersion of the two types of fibrils found in Swedish @entity5 @entity6 @entity0 -Type A consisting of a mixture of truncated and full length @entity5 fibrils and type B fibrils consisting of full length fibrils, and to estimate the severity of @entity2 in relation to fibril composition and sex. MATERIAL AND METHODS: Echocardiographic data were analysed in 107 Swedish @entity5 @entity6 @entity0 with their fibril composition determined as either @entity3 or type B. Measurements of left ventricular (LV) dimensions and evaluation of systolic and diastolic function including speckle tracking derived strain were performed. @entity0 were grouped according to fibril type and sex. Multivariate linear regression was utilised to determine factors of significant impact on LV thickness. RESULTS: There was no significant difference in proportions of the two types of fibrils between @entity0 and @entity0 . In @entity0 with @entity3 fibrils, @entity0 had significantly lower median septal (p = 0.007) and posterior wall thicknesses (p = 0.010), lower median LV mass indexed to height (p = 0.008), and higher septal strain (p = 0.037), as compared to males. These differences were not apparent in @entity0 with type B fibrils. Multiple linear regression analysis revealed that fibril type, sex and age all had significant impact on LV septal thickness. CONCLUSION: This study demonstrates a clear difference between sexes in the severity of @entity2 in @entity5 @entity6 @entity4 @entity0 . Even though @entity3 fibrils were associated with more advanced @entity2 compared to type B, @entity0 with @entity3 fibrils generally developed less cardiac infiltration than @entity0 . The differences may explain the better outcome for liver transplanted late-onset female @entity0 compared to males.

title: Amyloid Cardiomyopathy in Hereditary @entity5 XXXX Amyloidosis - Impact of Sex and Amyloid Fibril Composition.

answer: @entity6


abstract: AIM: To assess the treatment outcome in @entity0 with @entity5 and prognostic factors for @entity1 ( @entity1 ), @entity3 ( @entity3 ) and @entity7 ( @entity7 ). MATERIALS AND METHODS: A retrospective analysis was conducted on 113 @entity0 with @entity5 (60 females, 53 males, average age-55 years) who were treated surgically. Primary treatment consisted of local excision. In 12 cases, it was accompanied by lymph node excision. In 93 (82%) cases, radicalization was necessary, which was either local only (19 cases) or accompanied by lymph node surgery/biopsy (74 cases). Possible prognostic factors such as Clark's stage and Breslow's depth of invasion, @entity6 , average @entity2 dimensions, lymph nodes @entity1 (pN+), gender, @entity2 location and primary excision margins were considered. RESULTS: In 51 (45%) cases, treatment failure occurred. The 5-year @entity1 rate was 47%, the 5-year @entity3 was 38%, and the 5-year @entity7 was 56%. In the univariate analysis, the important factors with respect to at least one endpoint included Clark's stage, Breslow's depth of invasion, @entity6 , average @entity2 dimensions, lymph nodes @entity1 , gender and @entity2 localization. The presence of metastasic nodes was the most important prognostic factor, with a 5-year @entity1 rates of 30% for pN(-) and 76% for pN(+) and a 5-year @entity3 and @entity7 of 56% and 76% for pN(-) and 13% and 24% for pN(+), respectively. The average @entity2 dimension was independently significant for @entity3 and @entity7 , with 5-year rates of 69% and 80% for  <=1 cm, 28% and 53% for 1-2 cm, and 18% and 30% for >2 cm, respectively. @entity2 location was also significant for @entity1 and @entity7 , with 5-year rates of 69% vs 33% and 41% vs 66% for trunk vs other locations, respectively. CONCLUSIONS: The natural course of a @entity5 treated radically is disadvantageous, with unsuccessful outcome in nearly half of the cases. Common clinical factors, such as Clark's @entity2 stage, Breslow's depth of invasion and the presence of metastatic nodes, have high prognostic significance. The size and location of the @entity4 may be considered independent prognostic factors. The most important negative prognostic factor is the presence of metastatic regional lymph nodes. Only one quarter of @entity0 with @entity1 in lymph nodes survive 5 years from primary surgery.

title: Treatment Outcome and Prognostic Factors for Malignant XXXX Treated with Radical Surgery.

answer: @entity5


abstract: BACKGROUND AND PURPOSE: The arctic and sub-arctic waters of Alaska provide a very hazardous work setting, with special hazards posed by great distances, seasonal darkness, cold waters, high winds, brief fishing seasons, and icing. Our intent is to reduce the remarkably high occupational fatality rate (200/100,000/year in 1991-1992) among Alaska's commercial fishing workers. Over 90% of these @entity1 have been due to @entity3 or @entity3 plus @entity2 , primarily associated with vessel capsizings and sinkings. METHODS: Comprehensive surveillance for commercial fishing occupational fatalities was established during 1991 in Alaska. During 1990 through 1994, the U.S. Commercial Fishing Industry Vessel Safety Act of 1988 required the implementation of comprehensive prevention measures for all fishing vessels in offshore cold waters, including immersion suits and other personal flotation devices, survival craft (life rafts), emergency position-indicating radio beacons, and crew training in emergency response and first aid. Parallel to this, voluntary training efforts by nonprofit organizations have greatly increased. RESULTS: During 1990-1994, @entity3 was the leading cause of occupational death in Alaska. During this period, 117 fishers died, 101 of them from @entity3 or @entity3 / @entity2 . During 1991-1994, there was a substantial decrease in Alaskan commercial fishing-related @entity1 , from 34 in 1991 to 35 in 1992, 22 in 1993, and 10 in 1994. While @entity0 -overboard drownings and some other categories of @entity1 (falls, fires) have continued to occur, the most marked progress has been in vessel-related events. CONCLUSION: Specific measures tailored to prevent @entity3 in vessel capsizings and sinkings in Alaska's commercial fishing industry have been very successful so far. Additional efforts must be made to reduce the frequency of vessel events and to prevent @entity0 -overboard events and drownings associated with them.

title: Preventing XXXX in Alaska's commercial fishing industry.

answer: @entity1


abstract: OBJECTIVE: The purpose of this study was to compare the 1-year results of @entity0 on whom we used the transobturator tape method for the @entity2 treatment according to body mass index (BMI). MATERIAL AND METHODS: @entity0 diagnosed with @entity2 and treated with the transobturator tape method were divided into three groups according to BMI. We recorded the results of preoperative urodynamic studies; durations of operation, catheterization, and hospitalization; and complications of @entity0 . @entity0 were evaluated 1 year after the operation with respect to the objective/subjective success rates of the operation, @entity0 satisfaction rates, and possible late complications. RESULTS: The @entity1 group was observed to have a significantly higher duration of operation than the normal and overweight groups (p<0.001). The objective and subjective success rates were not significantly different between the groups (p=0.567 and p=0.245, respectively). There was no statistical difference between the groups with respect to the satisfaction rates (p=0.245). There was no significant difference between all three groups with respect to both preoperative and postoperative complication rates (p=0.096). CONCLUSION: The transobturator tape method for @entity2 treatment has similar objective and subjective success rates, independent of BMI. In the @entity1 @entity0 , the operation time is longer than the others, but there is no difference with respect to the complication rates.

title: Comparison of one-year results of transobturator tape method in the XXXX treatment according to body mass index.

answer: @entity2


abstract: @entity1 receptors (NMDARs) are tetrameric protein complexes usually comprising two @entity6 and two NR2 subunits. Different combinations of four potential NR2 subunits (NR2A-D) confer diversity in developmental expression, subsynaptic localization, and functional characteristics, including affinity for neurotransmitter. @entity5 -containing NMDARs, for example, exhibit relatively high affinity both for @entity2 and the coagonist @entity3 . Although multiple NMDAR subtypes can colocalize at individual synapses, particular subtypes often mediate inputs from distinct functional pathways. In @entity4 cells (RGCs), NMDARs contribute to synaptic responses elicited by light stimulus onset ("ON") and offset ("OFF"), but roles for particular NMDAR subtypes, and potential segregation between the ON and OFF pathways, have not been explored. Moreover, elements in the retinal circuitry release two different NMDAR coagonists, @entity3 and @entity7 , but the effects of endogenous coagonist release on the relative contribution of different NMDAR subtypes are unclear. Here, we show that coagonist release within the retina modulates the relative contribution of different NMDARs in the ON pathway of the @entity0 retina. By pharmacologically stimulating functional pathways independently in acute slices and recording synaptic responses in RGCs, we show that ON inputs, but not OFF inputs, are mediated in part by NMDARs exhibiting @entity5 -like pharmacology. Furthermore, suppressing release of NMDAR coagonist reduces NMDAR activation at ON synapses and increases the relative contribution of these putative @entity5 -containing receptors. These results demonstrate direct evidence for evoked coagonist release onto NMDARs and indicate that modulating coagonist release may regulate the relative activation of different NMDAR subtypes in the ON pathway.

title: Coagonist release modulates XXXX receptor subtype contributions at synaptic inputs to @entity4 cells.

answer: @entity1


abstract: Previous functional imaging studies have pointed to the compensatory recruitment of cortical circuits in old age in order to counterbalance the @entity2 and preserve cognitive performance. Recent electroencephalographic (EEG) analyses reported age-related deficits in the amplitude of an early @entity3 ( @entity3 (wm)) component as well as changes in working memory (WM)-load related @entity1 during the successful performance of the n-back task. To explore the age-related differences of EEG activation in the face of increasing WM demands, we assessed the @entity3 (wm) component area, parietal alpha @entity4 ( @entity4 ) as well as frontal theta @entity4 in 32 young and 32 elderly healthy individuals who successfully performed a highly WM demanding 3-back task. @entity3 (wm) area increased with higher memory loads (3- and 2-back > 0-back tasks) in younger subjects. Older subjects reached the maximal values for this EEG parameter during the less WM demanding 0-back task. They showed a rapid development of an alpha @entity4 that reached its maximal amplitude at around 800 ms after stimulus onset. In younger subjects, the late alpha @entity4 occurred between 1,200 and 2,000 ms and its amplitude was significantly higher compared with elders. Frontal theta @entity4 culmination peak decreased in a task-independent manner in older compared with younger cases. Only in younger individuals, there was a significant decrease in the phasic frontal theta @entity4 amplitude in the 2- and 3-back tasks compared with the detection and 0-back tasks. These observations suggest that older adults display a rapid mobilization of their neural generators within the parietal cortex to manage very low demanding WM tasks. Moreover, they are less able to activate frontal theta generators during attentional tasks compared with younger @entity0 .

title: Age-related differences on event-related potentials and XXXX during working memory activation.

answer: @entity1


abstract: The most consistent biological findings in @entity0 with @entity1 are abnormalities in the @entity6 , which can be measured using the combined @entity2 -suppression/CRH-stimulation (Dex-CRH) test. The reactivity of the @entity6 in this test, however, ranges over several orders of magnitude in @entity1 @entity0 with comparable severity of symptoms. In this present study, we investigate which factors influence the magnitude of the response in the Dex-CRH test in 235 acutely @entity1 in- @entity0 . We first examined the effects of common confounders shown to influence the @entity6 , such as @entity7 and @entity4 consumption, acute stressors during the test, weight, gender, and age. Of all these variables, only female sex and @entity4 consumption were positively correlated with the @entity3 or ACTH response, respectively. As for the effects of psychopharmacological treatment, only the intake of @entity5 and the fact of having relapsed under an established pharmacotherapy significantly increased the response in the Dex-CRH test, whereas the presence or absence of antidepressant treatment, the type of antidepressant treatment, or the number of ineffective antidepressant treatment trials during the index episode up to admission did not have any effect. We also found a positive correlation of the number of previous episodes, the overall HAM-D score and the severity of somatic/vegetative symptoms with the results in the Dex-CRH test. These results underline that in @entity1 @entity0 this test is not majorly influenced by disease-unrelated factors. In addition, current antidepressant treatment does not appear to affect test outcome in the absence of clinical response. The influence of the number of previous episodes and relapse under pharmacotherapy suggests that @entity6 reactivity may be altered by repetitive states of hypercortisolemia or continuous antidepressant treatment. Finally, more severe vegetative symptoms are associated with an enhanced @entity6 activity.

title: Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely @entity1 psychiatric in- XXXX , measured by the Dex-CRH test.

answer: @entity0


abstract: @entity4 ( @entity4 ) is @entity1 of the tracheobronchial bud derived from the primitive foregut which is predominantly found in the mediastinum. Surgery remains the most common treatment when @entity0 is suspected, or when there are presenting. Only infrequently, is @entity4 located at an extrathoracic site. Although rarely located in the stomach, @entity4 should be considered as a differential diagnosis of @entity2 . For these cases, surgery remains a common choice. Minimally invasive procedures such as endoscopic ultrasonography-guided fine needle biopsy aspiration (EUS-FNA) and endoscopic submucosal dissection (ESD) should also be considered when the diagnosis of @entity4 is suspected. They are valuable diagnostic methods that can assess and identify the location of the lesion, and facilitate histological examination of the cyst. In some cases of more superficial lesions ESD can take the place of surgery as it avoids unnecessary complications of a more invasive procedure. Here we present a case of gastric @entity4 located in the fundus of the stomach that resembled a @entity3 ( @entity3 ). We discuss its embryology, pathogenesis, radiological, clinical and treatment modalities. We also provide a thorough review of 14 cases (including our own case), which completely meet pathological criteria has been undertaken focusing on symptom, location, treatment, and histological features.

title: Gastric bronchogenic cyst presenting as a XXXX .

answer: @entity3


abstract: BACKGROUD: @entity5 ( @entity5 ) is an uncommon but catastrophic @entity2 with high rate of intestinal failure and mortality. The retrospective pilot study was performed to assess the effect of a multidisciplinary stepwise management strategy on survival and mesenteric recanalization in an integrated intestinal @entity1 center (ISC). MATERIALS AND METHODS: A modern management strategy performed by multidisciplinary specialists in ISC was evaluated among 43 @entity5 @entity0 that were classified into central vs peripheral type, operative vs nonoperative, early vs late treated group from March 2009 to April 2013. @entity0 received specific medical therapy, endovascular treatment, damage-control surgery, selective second-look laparotomy, critical care management, and clinical nutrition support in a stepwise way. The demographics, etiology, imaging characteristics, treatment procedures, complications, clinical outcome, and 1-year follow-up data were analyzed and compared. Confounding factors of mortality were identified by univariate and ROC-curve analysis. A single-center experience of over 5years for this modern strategy was also reported. RESULTS: The protocol of multidisciplinary stepwise management strategy was followed in all @entity5 @entity0 successfully. The 30-day mortality and recanalization rate were 11.63% and 90.70%. Initial damage-control surgery was carried out in 46.51% @entity0 , with selective second-look laparotomy in 23.26% @entity0 . Endovascular thrombolysis was performed in 83.72% @entity0 initially or postoperatively. Bowel resection was necessary in 18 @entity0 with the length of 100.00 (47.50, 222.50) cm. The incidence of @entity4 was 13.95%. The rate and length of bowel resection, @entity4 rate were significantly lower in nonoperative and early-treated groups (P<0.05). During the follow-up survey, 1-year survival was 83.72%, with no additional death or re- @entity3 . CONCLUSION: A multidisciplinary stepwise management strategy involving modern surgical and endovascular treatments that focus on early mesenteric recanalization and bowel viability salvage in a specialized ISC could significantly improve the clinical outcome of @entity5 @entity0 .

title: Multidisciplinary stepwise management strategy for acute superior mesenteric venous thrombosis: an intestinal XXXX center experience.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to better understand barriers and facilitators of @entity1 self-management education (DSME) among Arab American @entity0 with @entity1 . Little is known about the impact of Arab culture on DSME. METHODS: Arab American adults (N = 23) with medically managed @entity1 participated in 1 of 3 focus groups. An Arabic-speaking, trained moderator conducted video-recorded sessions. Verbatim Arabic transcripts were translated into English. Transcripts underwent a qualitative content analysis approach. RESULTS: Arab American cultural traditions such as food sharing, religious beliefs, and gender roles both facilitated and at times impeded DSME. @entity0 also held conflicting views about their interactions with their providers; some @entity0 praised the authoritative @entity0 -physician relationship style while others perceived the gaps in communication to be a product of Arab culture. @entity0 expressed that lack of available educational and supportive resources are key barriers to DSME. CONCLUSION: Arab American culture affects DSM activities, and culturally sensitive educational resources are lacking. Development of DSME programs tailored to address relevant aspects of Arab culture might improve DSME outcomes in Arab American population.

title: The Impact of Arab American Culture on XXXX Self-management Education.

answer: @entity1


abstract: PURPOSE: This report presents an update to the @entity2 ( @entity2 ) @entity1 ( @entity1 ) brachytherapy guidelines for locally advanced cervical @entity0 . METHODS: Members of the @entity2 with expertise in cervical @entity0 formulated updated guidelines for @entity1 brachytherapy using tandem and ring, ovoids, cylinder, or interstitial applicators for locally advanced cervical @entity0 . These guidelines were written based on medical evidence in the literature and input of clinical experts in gynecologic brachytherapy. RESULTS: The @entity2 affirms the essential curative role of tandem-based brachytherapy in the management of locally advanced cervical @entity0 . Proper applicator selection, insertion, and imaging are fundamental aspects of the procedure. Three-dimensional imaging with magnetic resonance or computed tomography or radiographic imaging may be used for treatment planning. Dosimetry must be performed after each insertion before treatment delivery. Applicator placement, dose specification, and dose fractionation must be documented, quality assurance measures must be performed, and followup information must be obtained. A variety of dose/fractionation schedules and methods for integrating brachytherapy with external-beam radiation exist. The recommended @entity0 dose in 2-Gray (Gy) per fraction radiobiologic equivalence (normalized therapy dose) is 80-90Gy, depending on @entity0 size at the time of brachytherapy. Dose limits for normal tissues are discussed. CONCLUSION: These guidelines update those of 2000 and provide a comprehensive description of @entity0 brachytherapy in 2011.

title: XXXX consensus guidelines for locally advanced carcinoma of the cervix. Part II: @entity1 brachytherapy.

answer: @entity2


abstract: BACKGROUND: In @entity0 with @entity6 , circulating lymphocytes are activated, and histological findings indicate that cell-mediated immunity plays an important role in the pathogenetic sequence leading to @entity2 . METHODS AND RESULTS: To delineate the profile of inflammatory and chemoattractant cytokines involved in T-cell activation in @entity6 , we measured by ELISA serum levels of @entity3 , @entity4 , and @entity5 in 18 @entity0 . Subsequently, we wanted to establish whether any of these molecules could be used as a marker to monitor the clinical course of the disease and to predict disease exacerbations. We found that all @entity0 with @entity6 studied during an active phase of the disease have increased serum concentration of @entity3 compared with healthy control subjects (P<0.01). Enhanced @entity3 serum levels paralleled disease activity to the extent that its serum concentrations were comparable to those of control subjects when @entity0 were studied in remission. @entity5 concentrations were also higher than normal in the serum of all @entity0 with @entity6 (P<0.01) studied during an active phase of the disease. @entity5 serum levels tended to normalize in remission, but values remained higher than those of control subjects (P<0.05). In contrast, serum concentrations of @entity4 were below the detection limit of ELISA in both healthy subjects and all @entity0 with @entity6 . A positive correlation was found between either @entity3 (rho=0.705, P<0.01) or @entity5 (rho=0.607, P<0.05) serum level and disease activity. CONCLUSIONS: The close correlation of serum @entity3 and @entity5 levels with disease activity suggests that these cytokines contribute to @entity1 in @entity6 and raises the possibility that their monitoring in serum helps clinicians find adequate treatment adjustments in individual @entity0 .

title: @entity3 and @entity5 in XXXX : a guide for therapeutic decisions?

answer: @entity6


abstract: PURPOSE: Ambulatory EEGs in @entity0 are frequently ordered as sleep studies. However, the yield according to different clinical situations has received little attention to date. The authors aimed to quantify the added value in terms of detection of epileptiform features of an EEG containing sleep, as compared with only wakefulness, according to the referral diagnoses. METHODS: The authors retrospectively selected consecutive outpatients' EEG recordings of @entity0 between 6 months to 16 years old, performed between January 2014 and February 2015. The authors excluded those lacking at least 10 minutes of waking and/or at least 5 minutes of behavioral sleep. @entity2 ( @entity2 ) in wakefulness and sleep was compared among referral suspected diagnoses. @entity1 was considered if at least one of the following was observed: appearance of @entity2 or increase by >50%; @entity2 change in localization or morphology, @entity3 occurrence. RESULTS: A total of 425 recordings (mean age 6.9    4.7 years) were analyzed. Of them, 194 (45.6%) presented an additional yield during sleep, which was dependent on the occurrence of @entity2 during wakefulness: 77/251 (30.7%) in those without versus 117/174 (67.2%) in those with wakefulness @entity2 (P < 0.001,   ). The yield was markedly lower in studies performed for nonepileptic referral diagnoses (7% vs. 43% to 100%; P < 0.001, Fisher). CONCLUSIONS: When wakefulness EEG lacks epileptiform features, the yield of sleep EEG in our pediatric population appeared modest, especially in @entity0 without a suspected @entity2 . This information may be used to optimize the request of sleep EEG in @entity0 .

title: Yield of Outpatient Sleep EEG for Epileptiform Alterations' Detection in XXXX .

answer: @entity0


abstract: Background. Metabolism in the @entity0 microenvironment can play a critical role in tumorigenesis and @entity0 aggression. Metabolic coupling may occur between @entity0 compartments; this phenomenon can be prognostically significant and may be conserved across @entity0 types. Monocarboxylate transporters (MCTs) play an integral role in cellular metabolism via @entity1 transport and have been implicated in metabolic synergy in @entity0 . The transporters @entity2 and @entity3 are regulated via expression of their chaperone, @entity4 . Methods. We conducted a meta-analysis of existing publications on the relationship between @entity2 , @entity3 , and @entity4 expression and overall survival and disease-free survival in @entity0 , using hazard ratios derived via multivariate Cox regression analyses. Results. Increased @entity3 expressions in the @entity0 microenvironment, @entity0 cells, or stromal cells were all associated with decreased overall survival and decreased disease-free survival (p < 0.001 for all analyses). Increased @entity4 expression in @entity0 cells was associated with decreased overall survival and disease-free survival (p < 0.0001 for both analyses). Few studies were available on @entity2 expression; @entity2 expression was not clearly associated with overall or disease-free survival. Conclusion. @entity3 and @entity4 expression correlate with worse prognosis across many @entity0 types. These results warrant further investigation of these associations.

title: Prognostic Indications of Elevated @entity3 and XXXX across Cancer Types: A Meta-Analysis.

answer: @entity4


abstract: PURPOSE: To report two different cases of sterile, @entity3 following laser in situ keratomileusis (LASIK). METHODS: A report of two cases (two eyes of two @entity0 ). RESULTS: In two @entity0 , peripheral infiltrates appeared 1 day after LASIK. One @entity0 had a history of @entity2 and both had peripheral corneal changes that may have represented prior inflammatory events. The presentations were quite different, with one occurring in association with an epithelial defect at the edge of the flap and the other occurring without an epithelial defect peripheral to the microkeratome cut. In the second case a similar infiltrate showed up in the unoperated fellow eye. Both @entity0 were treated with aggressive antibiotic and corticosteroid therapy. Both @entity0 recovered well with no loss of best spectacle-corrected visual acuity. CONCLUSION: @entity3 can occur in @entity0 following LASIK; preoperative evidence of previous @entity1 may be a marker for @entity0 at higher risk. @entity2 @entity0 may be at increased risk for this complication. With careful and aggressive management excellent visual outcomes are still possible.

title: XXXX following laser in situ keratomileusis.

answer: @entity3


abstract: BACKGROUND: Causes of @entity4 in @entity2 ( @entity2 ) are less well understood than in @entity6 , but have been thought to result from direct effects of subcortical lacunes and @entity1 , perhaps related to disruption of important cortical-subcortical pathways. OBJECTIVE: To examine the relation between cognitive abilities and quantitative MRI measures of subcortical @entity3 and cortical and hippocampal @entity5 . METHODS: Subjects were 157 @entity0 in a multicenter study of @entity2 and @entity6 who included cognitively normal, @entity4 , and demented individuals with and without subcortical @entity7 . Dependent variables were neuropsychological tests of global cognitive function, memory, language, and executive function. Independent variables were quantitative MRI measures of volume of @entity7 in specific subcortical structures, volume of @entity1 ( @entity1 ), volume of cortical gray matter (cGM), and total hippocampal volume (HV). Multiple regression analyses were used to identify MRI predictors of cognition. RESULTS: Subcortical lacunes were not related to cognitive measures independent of effects of other MRI variables. @entity1 was independently related to selected, timed measures. HV and cGM were strong and independent predictors of cognitive variables, with effects that did not differ in subjects with and without subcortical lacunes. CONCLUSIONS: Results suggest that @entity4 associated with @entity2 is primarily a result of associated hippocampal and cortical changes.

title: MRI predictors of cognition in @entity2 and XXXX .

answer: @entity6


abstract: BACKGROUND: The National @entity1 Data Base (NCDB) has reported on many @entity1 occurring in @entity0 and @entity0 in the U. S. from >1400 contributing hospitals. The current report on @entity5 ( @entity5 ) is a companion to an upcoming @entity0 Care Evaluation study of this relatively common and serious @entity1 . METHODS: This report is comprised of all @entity5 cases submitted to the NCDB divided into two diagnostic-year groups: 1985-1988 and 1990-1993. Variables routinely collected by hospital @entity1 registries have been analyzed to report on patterns of diagnosis and treatment. RESULTS: High grade @entity5 cases were more likely to be Stage IV (40.8%) than were low or intermediate grade cases (34.8% and 32.5%, respectively). @entity0 with @entity5 arising from lymph node sites tended to present with more @entity4 (55.8% with Stages III and @entity3 ), whereas @entity0 with @entity5 arising from extranodal sites and non-lymph node nodal sites presented at an earlier stage (64.7% and 74.0%, respectively, with Stage I or @entity2 ). Approximately 67% of all @entity0 underwent chemotherapy, whereas only 25% underwent surgery or radiation. By histology, 5-year survival was 68.8% for low grade disease, 51.9% for intermediate grade disease, and 45.8% for high grade disease; by stage, survival rates ranged from 73.5% for Stage I to 42.9% for Stage @entity3 . CONCLUSIONS: To the authors' knowledge, the 91,306 cases in this study represent the largest contemporary sample of @entity5 @entity0 . The material reported here may serve as a reference with which to compare local patterns with national data. The Working Formulation's ability to stratify @entity0 ' survival rates confirms its utility for @entity5 . Stage according to the American Joint Committee on @entity1 also was accurate in predicting survival.

title: The National @entity1 Data Base report on XXXX .

answer: @entity5


abstract: STUDY OBJECTIVES: Forty-one percent of shift workers report dozing while driving. This study tested whether @entity4 improves driving simulator performance in subjects with @entity3 ( @entity3 ). A primary outcome was performance late in the shift when workers are typically driving home. DESIGN: Randomized, double-blind, crossover. During each 12-h test session (21:30-09:30), subjects were kept awake except for multiple sleep latency testing (MSLT: 01:30, 03:30, 05:30, and 07:30). @entity1 (Karolinska Sleepiness Scale, KSS), driving performance, and cognitive performance (digit symbol substitution test and creativity on the Remote Associates Test, @entity2 ) were evaluated during the night shift and commute home times. SETTING: Hospital-based sleep research laboratory. @entity0 : Twenty night workers (age: 42.7    8.7 y, 17 F) with excessive @entity1 (>=  10 on the Epworth Sleepiness Scale), meeting International Classification of @entity1 , Second Edition (ICSD-2) criteria for @entity3 , and having no other medical conditions. INTERVENTIONS: @entity4 (150 mg) or placebo at (23:45 h) on counterbalanced nights separated by 7-14 days. MEASUREMENT AND RESULTS: Primary endpoints were driving simulator performance (standard deviation of lateral position (SDLP) and off-road deviations) with four sessions starting 3.25 h after drug administration, @entity1 (MSLT; 1.75 to 7.75 h post-drug), and creativity (5 h post-drug). Significant effects of drug were observed for each driving measure (P < 0.05). @entity4 significantly improved SDLP for simulator sessions at 05:30, 07:30, and 09:30, and off-road deviations at 7 h, 15 min and 9 h, 15 min post-drug (P < 0.05). @entity4 also improved @entity1 from 3.7    0.6 min to 9.7    5.2 min (P < 0.001) and @entity2 score from 8.75    4.9 to 11.25    6.0 (P < 0.005). CONCLUSIONS: @entity4 150 mg early in the night shift improves driving simulator performance in @entity3 . Effects on @entity1 , cognition, and driving were found up to 9.5 h post-ingestion, during the critical time when many night workers are driving home.

title: Effects of @entity4 on simulated driving and alertness in XXXX .

answer: @entity3


abstract: PURPOSE: The inguinovaginal sling procedure is well accepted for surgical treatment of female stress urinary @entity2 . Although the functional results are excellent, the operative @entity1 is higher compared to that of more recently used minimally invasive techniques. MATERIALS AND METHODS: A modified inguinovaginal sling procedure was performed in 15 @entity0 with urodynamically diagnosed @entity3 . With the assistance of a laparoscope, two fascial strips were dissected using two small suprapubic skin incisions. The pullthrough maneuver of the fascial slings was facilitated by opening the perivesical space with an inflatable balloon. RESULTS: There were no intraoperative or postoperative complications. Mean follow-up of 7.7 months (range 4 to 11) was available in all @entity0 . @entity4 was cured in 14 @entity0 ; only one @entity0 reported using one pad per day. All @entity0 were able to void spontaneously after a mean of 8 days (range 6 to 10). CONCLUSIONS: The laparoscopically assisted inguinovaginal sling procedure is less invasive than the original technique. Good long-term results are known from the original inguinovaginal sling procedure, and there is no need for allografts or synthetic material.

title: Inguinovaginal sling procedure for female stress XXXX : introduction of a minimally invasive technique.

answer: @entity2


abstract: PURPOSE: @entity4 plus @entity2 is a commonly used doublet for the treatment of advanced @entity3 ( @entity3 ). This study aimed to investigate the efficacy of oral @entity4 as maintenance therapy in advanced @entity3 . METHODS: This multicenter phase II open-label, non-comparative study was designed to evaluate the three-weekly combination of @entity2 80 mg/m(2) on day 1 in combination with oral @entity4 on day 1 and 8 in advanced @entity3 . RESULTS: Thirty-nine @entity0 were enrolled; median age was 63 years (range 42-82). In the response-evaluable population (n = 38), objective response after induction therapy was observed in 18 (47 %) @entity0 with two (5 %) @entity0 achieving complete response. Stable disease was observed in nine (24 %) @entity0 . The median duration of response was 6 months. Eighteen (46 %) @entity0 received oral @entity4 as maintenance therapy. The median PFS for the whole population and for the maintenance therapy group was 4.9 [95 % CI (2.8-6.9)] and 6.7 [95 % CI (3.7-9.7)] months, respectively, while the overall survival was 8.7 [95 % CI (5.4-11.9)] and 11 [95 % CI (8.3-13.7)] months, respectively. The main observed overall hematologic toxicities were grade 3 @entity1 (8 %) and grade 3/4 @entity5 (8 %). CONCLUSION: Maintenance therapy with single-agent oral @entity4 is feasible and well tolerated; it seems to extend the efficacy of the combination regimen with the advantage of being convenient to @entity0 .

title: Oral @entity4 plus @entity2 followed by maintenance oral @entity4 as first-line treatment for advanced XXXX .

answer: @entity3


abstract: The continuous use of @entity6 can result in the development of drug resistance. @entity7 -resistant clinical isolates, spontaneous and induced mutants of @entity0 have been documented. The azoles block the @entity9 biosynthesis pathway by inhibiting the enzyme 14-alpha-demethylase, product of the CYP51. Fungal @entity7 resistance involves both @entity2 changes in the target site that alter drug-target interactions and those that decrease net @entity7 accumulation. The reduced intracellular accumulation has also been correlated with overexpression of multidrug resistance (MDR) efflux transporter genes of the @entity3 -binding cassette (ABC) and the @entity5 ( @entity5 ) classes. About 20 genes are involved in the A. fumigatus @entity9 biosynthesis pathway. There are several duplicated genes in this pathway. Interestingly, erg3 and erg11 showed two copies in A. fumigatus. In general, @entity0 spp. have proportionally more @entity5 transporter encoding genes than @entity1 , @entity8 , and @entity4 . The drug H+ (12 and 14 spanners) sub-families are also proportionally greater than in the other species. Although the numbers of ABC transporter encoding genes are comparable, again the @entity0 spp. have more ABC transporters related to multidrug permease than the other fungal species.

title: The XXXX biosynthesis pathway, transporter genes, and @entity7 resistance in @entity0 .

answer: @entity9


abstract: OBJECTIVE: To determine the in-vitro effects of several non-steroidal antiinflammatory drugs and the glucocorticoid @entity1 on the IL-1 altered expression and activity of @entity6 , @entity7 and @entity8 by @entity0 articular chondrocytes. DESIGN: @entity0 chondrocytes were cultured in alginate gel beads. Cells were treated with @entity5 in the presence of vehicle or drugs at various concentrations. After 48 h mRNA expression of @entity6 , @entity7 , and of the tissue inhibitor of metalloproteinases ( @entity8 ) was analysed by RT-PCR-ELISA. The protein synthesis of @entity8 and @entity7 was determined by immunoprecipitation. The activity of enzymes and inhibitors was measured by functional assays. RESULTS: IL-1 increased the expression and activity of MMPs. In contrast, TIMP activity remained unchanged although @entity8 expression was down-regulated. All tested NSAIDs and @entity1 inhibited collagenase activity induced by IL-1. Transcript levels of @entity6 , however, were only reduced by @entity3 , @entity4 , @entity2 and @entity1 . Proteoglycanase activity was only reduced by @entity3 , @entity4 and @entity1 . These effects were pre-translational as confirmed by immunoprecipitation. The IL-1 decreased expression of @entity8 was further reduced by @entity1 , which resulted in a significant loss of TIMP activity. No effects on TIMP activity or @entity8 biosynthesis were observed after treatment of chondrocytes with NSAIDs. CONCLUSION: Our studies clearly demonstrate that marked differences exist between individual NSAIDs with respect to their ability to modulate the imbalance between proteases and inhibitors during OA and RA, suggesting that the respective modes of action are independent of the inhibition of cyclooxygenases. Due to their co-regulation of MMPs and TIMP(s) glucocorticoids should be carefully studied for their overall effect on ECM proteolysis.

title: Effects of non-steroidal antiinflammatory drugs and XXXX on the activity and expression of @entity6 by @entity0 articular chondrocytes.

answer: @entity1


abstract: @entity2 embryos at the blastula-early tail bud stage were exposed to @entity1 or @entity5 dissolved in culture saline until they reached the larval stage. The left-right asymmetry of the heart and gut was then examined. We found that these adrenergic neurotransmitters induced situs inversus in the heart and/or gut in up to 35% of tested neurula embryos. @entity1 -induced situs inversus was blocked by the alpha-1 adrenergic antagonist @entity3 . Furthermore, @entity4 , a @entity0 ionophore, also increased the incidence of situs inversus up to 54% when late-neurula embryos were exposed to the solution. @entity4 treatment initiated before neural groove formation was less effective. The incidence of situs inversus induced by these reagents decreased towards the control level (2.2%, 25 untreated embryos out of 1127 embryos in total) in embryos past the stage of neural tube closure. In the present experiments we obtained 22 gut-only situs inversus embryos having an inverted gut and a normal heart. In contrast, such embryos were not observed among the 1127 untreated embryos. An adrenergic signal mediated by an increase in intracellular free @entity0 may be involved in the asymmetrical visceral morphogenesis of @entity2 embryos.

title: Adrenergic neurotransmitters and @entity0 ionophore-induced situs inversus viscerum in XXXX embryos.

answer: @entity2


abstract: BACKGROUND: The most common historical treatment method for @entity3 is extensive soft-tissue release surgery. A minimally invasive treatment approach that relies primarily on serial cast correction was introduced almost ten years ago, with promising early results. The purpose of this study was to assess the long-term outcome of @entity0 with @entity3 managed with the minimally invasive technique and compare them with a cohort treated with extensive soft-tissue release surgery. METHODS: The records of twenty-seven consecutive @entity0 with @entity3 (forty-two feet) were retrospectively reviewed at a mean of seven years (range, five to 11.3 years) after initial correction was achieved. The minimally invasive method was used to treat sixteen @entity0 (twenty-four feet), and extensive soft-tissue release surgery was used to treat eleven @entity0 (eighteen feet). @entity0 demographics, ankle range of motion, the PODCI (Pediatric Outcomes Data Collection Instrument) questionnaire, and radiographic measurements were analyzed. RESULTS: At the latest follow-up, the mean range of motion of @entity0 treated with the minimally invasive method was 42.4   compared with 12.7   for @entity0 treated with extensive surgery (p < 0.0001). The PODCI normative @entity1 and global function scores were superior in the minimally invasive treatment group compared with the extensive soft-tissue release group. Greater correction of hindfoot valgus (anteroposterior talar axis-first metatarsal base angle) was achieved in the minimally invasive treatment group compared with the extensive surgery group (40.1   versus 27.9  , p = 0.03), although all other radiographic values were similar between the two groups (p > 0.1 for all). Subgroup analysis of @entity0 with isolated @entity3 also showed superior range of motion and PODCI normative global function scores in the minimally invasive group. CONCLUSIONS: The minimally invasive treatment method for @entity3 resulted in better long-term ankle range of motion and @entity1 scores compared with extensive soft-tissue release surgery. Longer-term studies are necessary to determine whether the improved outcomes are maintained into adulthood and whether the superior outcome is related to reduced @entity2 .

title: Treatment of XXXX : Comparison of Minimally Invasive and Extensive Soft-Tissue Release Procedures at Minimum Five-Year Follow-up.

answer: @entity3


abstract: PURPOSE: Social cognition captures affect recognition, social cue perception, "theory of mind," empathy, and attributional style. The aim of our study was to assess social cognition in @entity1 inpatients being treated with first-generation antipsychotic drugs (FGAs), n=28 ( @entity5 and @entity4 , FGAs) or with second-generation antipsychotic drugs (SGAs), n=56 ( @entity2 and @entity3 , SGAs). SUBJECTS AND METHODS: Eighty-four @entity0 completed the Facial Expression Recognition Test, the Voice Emotion Recognition Test, the Short Recognition Memory Test for Faces, and the Reading the Mind in the Eyes Test. @entity0 also completed the Visual Object and Space Perception Test (VOSP) as a control task, which would not engage social cognition. The @entity0 were compared with fifty healthy controls matched for age and gender. RESULTS: There were no significant differences on social cognitive performance between the @entity6 - and SGA-treatment groups. Nor was @entity2 superior to @entity3 , FGAs or both. However, @entity0 treated with FGAs performed significantly worse on VOSP compared to both groups treated with SGAs, a 10% difference. CONCLUSIONS: We cannot conclude that SGAs were associated with better social cognition than FGAs. However, there were small but significant advantages for SGAs in non-social visual processing function, as evaluated with the VOSP.

title: Social cognition and visual perception in XXXX inpatients treated with first-and second-generation antipsychotic drugs.

answer: @entity1


abstract: OBJECTIVE: This study evaluated the effect of @entity1 gels, supplemented or not with @entity5 (HMP), on enamel erosive wear in situ. METHODS: Twelve healthy volunteers wore palatal appliances containing four @entity0 enamel discs. Subjects were randomly allocated into four experimental phases (double-blind, crossover protocol) according to the gels: Placebo (no @entity1 or HMP), 1% @entity3 , 2% @entity3 , and 1% @entity3 +9% HMP. Enamel discs were selected after polishing and surface hardness analysis, and treated only once with the respective gels prior to each experimental phase. Erosion (ERO) was performed by extra-oral immersion of the appliance in 0.05M @entity2 , pH 3.2 (four times/day, five minutes each, 5 days). @entity4 (ERO+ABR) was produced on only two discs by toothbrushing with fluoridated dentifrice after ERO (four times/day, 30s, 5 days). The specimens were submitted to profilometry and hardness analysis. The results were analyzed by two-way ANOVA and the Student-Newman-Keuls test (p<0.05). RESULTS: The 1% @entity3 +9% HMP gel promoted significantly lower enamel wear for ERO compared to the other groups, being statistically lower than 1% @entity3 and Placebo for ERO+ABR. Similarly, the lowest values of integrated lesion area were found for 1% @entity3 +9% HMP and 2% @entity3 , respectively, for ERO and ERO+ABR. CONCLUSION: The addition of HMP to the 1% @entity3 gel promoted greater protective effect against ERO and ERO+ABR compared to the 1% @entity3 gel, achieving similar protective levels to those seen for the 2% @entity3 gel. CLINICAL SIGNIFICANCE: Gel containing 1% @entity3 +9% HMP showed a high anti-erosive potential, being a safer alternative when compared to a conventional 2% @entity3 gel.

title: @entity1 gel supplemented with XXXX reduces enamel erosive wear in situ.

answer: @entity5