abstract: HYPOTHESIS: The goals of this study were to identify the effects of @entity3 on the cochlea and to find out where the pathologic changes first occur. BACKGROUND: Some authors have stated that @entity3 alone does not produce @entity4 . Others propose that @entity4 is caused by glycogen accumulation and other alterations on cochlear ultrastructure. METHODS: Twenty @entity2 were classified as a control group fed with a normal diet, and a @entity1 group of 24 animals was given a diet composed of 1 g @entity1 per day for 4 months. The hearing acuity of the animals before the diets was compared with that after the diets by means of auditory brainstem responses. The basal and apical turns of the cochleas were examined by light microscopy and transmission electron microscopy. RESULTS: The control group showed normal cochlear ultrastructures consistent with normal hearing thresholds, whereas the @entity1 group had profound @entity0 in the strial marginal layer and slight @entity0 in the outer hair cells, in line with data from auditory brainstem responses revealing changes in hearing sensitivity in various degrees. The pathologic changes in the basal turn and the stria vascularis were qualitatively prominent in comparison with those of the apical turn and the outer hair cell. CONCLUSIONS: These observations confirm that @entity3 alone may cause @entity4 if dietary @entity1 is kept at a high level for a long time. Alterations attributed to @entity3 begin in the stria vascularis and then spread over the outer hair cells, mainly in the basal turn.

title: Ultrastructural effects of XXXX on the cochlea.

answer: @entity3


abstract: @entity8 is one of the leading causes of @entity3 associated with biofilm formation on implant devices. @entity7 are at risk of @entity8 transcutaneous contamination leading to higher non-union development compared to closed @entity2 . Although the role of @entity3 in delaying @entity2 healing is well recognized, no in vivo models investigated the impact of subclinical low-grade infections on bone repair and non-union. We hypothesized that the non-union rate is directly related to the load of this commonly retrieved pathogen and that a low-grade contamination delays the @entity2 healing without clinically detectable @entity3 . @entity0 femurs were osteotomized and stabilized with plates. @entity2 were infected with a characterized clinical-derived @entity4 -resistant @entity8 (103, 105, 108 colony forming units) and compared to uninfected controls. After 56 days, bone healing and @entity5 were clinically assessed and further evaluated by micro-CT, microbiological and histological analyses. The biofilm formation was visualized by scanning electron microscopy. The control group showed no signs of @entity3 and a complete bone healing. The 103 group displayed variable response to @entity3 with a 67% of altered bone healing and positive bacterial cultures, despite no clinical signs of @entity3 present. The 105 and 108 groups showed severe signs of @entity5 and a non-union rate of 83-100%, respectively. The cortical bone reaction related to the periosteal elevation in the control group and the metal scattering detected by micro-CT represented limitations of this study. Our model showed that an intra-operative low-grade @entity8 contamination might prevent the bone healing, even in the absence of infectious signs. Our findings also pointed out a dose-dependent effect between the @entity8 inoculum and non-union rate. This pilot study identifies a relevant preclinical model to assess the role of @entity6 in orthopaedic and @entity1 surgery and to test specifically designed diagnostic, prevention and therapeutic strategies.

title: Modeling XXXX -Induced Non-Unions: Subclinical and Clinical Evidence in @entity0 .

answer: @entity8


abstract: BACKGROUND: @entity0 simulators are computer-controlled mannequins that may increase realism during @entity2 training by providing real-time changes in vital signs and physical findings during @entity2 scenarios. We hypothesized that @entity2 assessment training on a @entity0 simulator would be as effective as training with a more traditional moulage @entity0 /actor. METHODS: This study was conducted during a surgery intern orientation at two academic @entity2 centers. Interns (n = 60) attended a basic @entity2 course, and were then randomized to @entity2 assessment practice sessions with either the @entity0 simulator (n = 30) or a moulage @entity0 (n = 30). After practice sessions, interns were randomized a second time to an individual @entity2 assessment test on either the simulator or the moulage @entity0 . Two surgeon-judges rated each intern live and on video for completion of 50 predetermined assessment objectives (total score) divided into sections (primary and secondary survey, general performance, diagnostic studies/procedures, and plan) and the identification and management of an acute @entity1 in the test @entity0 (event score). Multiple linear regression with random student effects was used to estimate the independent effects of all study variables. RESULTS: Within randomized groups, mean @entity2 assessment test scores for all simulator-trained interns were higher when compared with all moulage-trained interns (71 +/- 8 vs. 66 +/- 8, respectively; p = 0.02). Simulator training independently showed a small but statistically significant improvement in both the total score and the event score (+4.6 and +8.6, respectively; p < 0.05). CONCLUSION: Use of a @entity0 simulator to introduce @entity2 assessment training is feasible and compares favorably to training in a moulage setting. Continued research in this area of physician education is warranted.

title: Trauma assessment training with a XXXX simulator: a prospective, randomized study.

answer: @entity0


abstract: BACKGROUND: Thyroidectomy continues to be the least common form of therapy for @entity7 in the US, presumably based upon concerns about injuries to the recurrent laryngeal nerves and/or parathyroid glands. STUDY DESIGN: Concurrent and retrospective data were collected on 65 consecutive @entity0 undergoing subtotal or total thyroidectomy for @entity7 at one community-type hospital by one surgeon from 1992 to 2010. RESULTS: A total of 65 @entity0 (50 @entity0 , 15 @entity0 ) with a mean age of 38 years underwent subtotal (52.3%) or near total or total thyroidectomy (47.7%). Six @entity0 (9.2%) had high lying or @entity2 parathyroid glands reimplanted into the ipsilateral sternocleidomastoid muscle at the completion of the thyroidectomy, and none developed @entity8 . No injuries to the recurrent laryngeal nerve or external branch of the superior laryngeal nerve occurred. Seven @entity0 (10.8%) had 1 parathyroid gland removed inadvertently during thyroidectomy, but none developed @entity8 . Nine @entity0 (13.8%) were discharged from the hospital on supplemental @entity3 tablets for symptomatic or asymptomatic @entity8 ( @entity3 < 7.5 mg/dL). Four @entity0 were weaned off @entity3 tablets, and 5, all of whom had normocalcemia on supplementation, were lost to long-term follow-up. One @entity0 had reopening of the cervical incision under the same anesthetic for stridor that was subsequently found to have been caused by @entity6 , and 2 other @entity0 had reoperations for a cervical @entity5 (same day) and a reaction to @entity4 with facial and cervical @entity1 (tracheostomy, 11th day). No @entity0 is known to have developed a recurrence of @entity7 . CONCLUSIONS: Total thyroidectomy offers a rapid and complete cure for @entity7 . Extensive thyroidectomy for Graves' goiters can be safely performed in a community-type hospital.

title: Thyroidectomy is optimal treatment for XXXX .

answer: @entity7


abstract: UNASSIGNED: DNA methylation is an epigenetic mechanism that modulates gene expression in @entity0 cells including T cells. @entity4 cells are heterogeneous populations. @entity0 effector memory (EM) @entity3 (+) T cells in peripheral blood contain two cell subsets with distinct traits that express low and high levels of the @entity6 . However, epigenetic mechanisms involved in defining such cellular traits are largely unknown. In this study, we use genome-wide DNA methylation and individual gene expression to show the possible role of DNA methylation in conferring distinct traits of @entity5 and inflammatory responses in @entity0 @entity6 (low) and @entity6 (high) EM @entity3 (+) T cells. In particular, @entity6 (low) EM @entity3 (+) T cells had increased expression of @entity7 along with decreased DNA methylation in the @entity7 gene promoter compared with @entity6 (high) EM @entity3 (+) T cells. Altering the DNA methylation status of the @entity7 gene promoter changed its activity and gene expression. @entity6 (low) EM @entity3 (+) T cells had an increased migratory capacity to the @entity7 ligand fractalkine compared with @entity6 (high) EM @entity3 (+) T cells, suggesting an important biological outcome of the differential expression of @entity7 . Moreover, @entity6 (low) EM @entity3 (+) T cells induced fractalkine expression on endothelial cells by producing @entity2 and @entity1 , forming an autocrine amplification loop. Overall, our study shows the role of DNA methylation in generating unique cellular traits in @entity0 @entity6 (low) and @entity6 (high) EM @entity3 (+) T cells, including differential expression of @entity7 , as well as potential biological implications of this differential expression.

title: DNA Methylation Regulates the Differential Expression of XXXX on @entity0 IL-7Ralow and IL-7Rahigh Effector Memory @entity3 + T Cells with Distinct Migratory Capacities to the Fractalkine.

answer: @entity7


abstract: BACKGROUND:    Bicuspid aortic valves predispose to ascending @entity2 , but the mechanisms underlying this aortopathy remain incompletely characterized.   We sought to identify epigenetic pathways predisposing to @entity1 formation in bicuspid @entity0 . METHODS:    Ascending aortic @entity1 tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves.   Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays.   Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test.    RESULTS:    Twenty-seven probes in 9 genes showed significant differential methylation and expression (P<5.5x10-4).   The top gene was protein @entity5 phosphatase, non-receptor type 22 ( @entity6 ), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10-5) in bicuspid @entity0 , as compared to tricuspid @entity0 .   Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including @entity7 (4 probes, delta beta range:   -10.0 to -22.9%), which when mutated causes the syndrome of @entity4 and dissections CONCLUSIONS:    Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending @entity2 in @entity0 with bicuspid aortic valves, modulated through epigenetic mechanisms.   The top gene was @entity6 , which is involved in T-cell receptor signaling and associated with various @entity3 .   These differences highlight novel potential mechanisms of @entity1 development in the bicuspid population.

title: Epigenetic profiling identifies novel genes for ascending aortic XXXX formation with bicuspid aortic valves.

answer: @entity1


abstract: The abnormal deposition of amyloid-b (Ab) peptides in the brain is the main neuropathological hallmark of @entity3 ( @entity3 ). @entity5 are formed by a heterogeneous mixture of Ab peptides, among which the most studied are Ab40 and Ab42. Ab40 is abundantly produced in the @entity0 brain, but the level of Ab42 is remarkably increased in the brain of @entity3 @entity0 . Aside from Ab40 and Ab42, recent data have raised the possibility that Ab43 peptides may be instrumental in @entity3 pathogenesis. Besides its length, whether the Ab aggregated form accounts for the @entity6 is also particularly controversial. Ab fibrils are generally considered as key pathogenic substances in @entity3 pathogenesis. Nevertheless, recent data implicated soluble Ab oligomers as the main cause of @entity4 and @entity7 in @entity3 . To further address this uncertainty, we analyzed the @entity6 of different Ab species and Ab forms at the cellular level. The results showed that Ab42 could form oligomers significantly faster than Ab40 and Ab43 and Ab42 oligomers showed the greatest level of @entity6 . Regardless of the length of Ab peptides, Ab oligomers induced significantly higher @entity1 compared with the other two Ab forms. Surprisingly, the @entity6 of fibrils in PC12 cells was only marginally but not significantly stronger than monomers, contrary to previous reports. Altogether, our findings demonstrate the high pathogenicity of Ab42 among the three Ab species and support the idea that Ab42 oligomers contribute to the pathological events leading to @entity2 in @entity3 . Copyright    2017 European Peptide Society and John Wiley _ Sons, Ltd.

title: Comparison of XXXX of different aggregated forms of Ab40, Ab42 and Ab43 in cell cultures.

answer: @entity6


abstract: OBJECTIVES: To assess the benefits of frenotomy on breastfeeding in @entity0 , and determine the influence of age. METHODS: A telephone questionnaire of all @entity0 diagnosed with @entity1 12 months was conducted pre-intervention and 1-month post-intervention. The @entity0 Breastfeeding Assessment Tool was used to assess breastfeeding. RESULTS: Of 54 @entity0 diagnosed with tongue-tie, 78 per cent of mothers participated in the survey. Eighty-six per cent of @entity0 underwent frenotomy, with no surgical complications. In the frenotomy group, 81 per cent of mothers reported improvement in breastfeeding, versus 17 per cent in the non-surgical group (p = 0.0074). In the frenotomy group, the mean (  standard deviation) @entity0 Breastfeeding Assessment Tool score was 3.33    1.51 pre-intervention, versus 9.19    2.44 post-intervention (p = 0.0001). In the non-surgical intervention group, the mean score (  standard deviation) was 4.17    0.75 pre-intervention, versus 6.00    1.73 post-intervention (p = 0.16). For @entity0 who underwent frenotomy, there was a reported improvement in 94 per cent of those aged less than 30 days, versus 68 per cent in @entity0 aged over 30 days (p = 0.092). CONCLUSION: Frenotomy is a safe, short procedure that improves breastfeeding outcomes, and is best performed at an early age.

title: XXXX to treat breastfeeding difficulties: our experience.

answer: @entity1


abstract: UNASSIGNED: OBJECTIVE The objective of this study was to assess the cross-sectional areas (CSAs) of lumbar paraspinal muscles in adults with @entity8 ( @entity8 ), to compare them with those in the normative population, and to evaluate their correlations with demographic factors and MRI changes in various spinal elements. METHODS The authors conducted a retrospective study of @entity0 who had undergone posterior lumbar interbody fusion for @entity8 , and 2 of the authors acting as independent observers calculated the CSAs of various lumbar paraspinal muscles (psoas, erector spinae [ES], multifidus [MF]) on preoperative axial T2-weighted MR images from the L-3 to L-5 vertebral levels and computed the CSAs as ratios with respect to the corresponding vertebral body areas. These values were then compared with those in an age- and sex-matched normative population and were analyzed with respect to age, sex, duration of symptoms, grade of listhesis, and various MRI changes at the level of the listhesis (pedicle signal change, @entity5 , and facetal @entity7 ). RESULTS Compared with values in normative controls, the mean CSA value for the ES muscle was significantly higher in the study cohort of 120 @entity0 (p = 0.002), whereas that for the MF muscle was significantly lower (p = 0.009), and more so in the @entity0 with @entity3 (p = 0.002). Magnetic resonance imaging signal change in the pedicle was seen in half of the @entity0 , all of whom demonstrated a Type 2 change. Of the variables tested in a multivariate analysis, age independently predicted lower area values for all 3 muscles (p  <= 0.001), whereas female sex predicted a lower mean psoas area value (p < 0.001). None of the other variables significantly predicted any of the muscle area values. A decrease in the mean MF muscle area value alone was associated with a significantly increased likelihood of a @entity3 (p = 0.039). CONCLUSIONS Compared with normative controls, @entity0 with @entity8 suffer selective @entity2 of their MF muscle, whereas their ES muscle undergoes a compensatory @entity4 . Advancing age has a detrimental effect on the areas of the lumbar PSMs, whereas female sex predisposes to a @entity1 . Multifidus @entity6 correlates with @entity3 , indicating the role of this deep stabilizer in the biomechanical stability of spondylolisthetic spines. This may be of clinical significance in targeted physiotherapy programs during the conservative management of @entity8 .

title: Lumbar paraspinal muscle morphometry and its correlations with demographic and radiological factors in adult XXXX : a retrospective review of 120 surgically managed cases.

answer: @entity8


abstract: UNASSIGNED: A 45-year-old male presented to our clinic with complaining of @entity3 for a month. The investigations showed a 59 * 24-mm myxoid mass on the right lateral bladder wall and this was removed with transurethral resection. The histopathology evaluation result was @entity7 (classic type). The medical history revealed that the @entity0 had undergone inguinal orchiectomy for a @entity2 10 years before and the diagnosis was @entity7 . He received chemotherapy following the orchiectomy, but had not gone for follow-up after the first year. There was no other @entity1 and he was put on the @entity5 , @entity6 , @entity4 (IPE) protocol. The @entity0 has been disease-free for the last 5 months and the @entity2 markers and cystoscopy were normal. @entity2 can rarely cause other organ metastases in the late stage even if curative surgery and chemo-radiotherapy were initially administered. Proper follow-up is crucial. It is also necessary to query the @entity2 history when a @entity2 in any organ is considered.

title: Rare late XXXX of testis @entity7 to the bladder.

answer: @entity1


abstract: BACKGROUND: The aim of this study is to elucidate the optimal candidate of selective lymph node dissection (LND) that reduces the extent of mediastinal LND according to clinical information including radiological evaluation in primary @entity5 ( @entity5 ) @entity0 . METHODS: Eight hundred and seventy-six @entity0 with clinical(c)-stage I @entity5 ( @entity3 and @entity4 ), who underwent complete surgical resection between January 2003 and December 2009 were included in this study. We elucidated the lymph node metastatic incidence and distribution according to the @entity2 lobe location and extracted the associated clinicopathological factors, especially thin-section computed tomographic findings, with mediastinal lymph node involvement. RESULTS: The total incidence of mediastinal lymph node @entity1 was 9.1%. There were no cases with hilar and mediastinal lymph node @entity1 in ground glass opacity-predominant @entity2 . There was no significant association of clinical factors with subcarinal lymph node @entity1 in right @entity6 and left upper-division @entity3 . An elevated preoperative serum carcinoembryonic antigen level (p < 0.001) showed significant associations with upper mediastinal lymph node @entity1 in the @entity0 with bilateral lower-lobe primary @entity7 . CONCLUSIONS: It would be acceptable to perform selective LND in @entity0 with c-stage I @entity5 with ground glass opacity- predominant @entity2 . Elevated serum carcinoembryonic antigen was associated with upper mediastinal lymph node involvement in lower-lobe primary @entity7 with radiologically solid-predominant @entity2 . We should be careful when applying selective LND to @entity0 with solid-predominant @entity2 , especially located in the lower lobe.

title: Mediastinal nodal involvement in @entity0 with clinical stage I XXXX : possibility of rational lymph node dissection.

answer: @entity5


abstract: BACKGROUND AND OBJECTIVES: Protein-energy and micronutrient @entity0 are global public health problems which, when not prevented and severe, require medical management by clinicians with nutrition expertise, preferably as a collectively skilled team, especially when disease-related. This study aimed to investigate barriers and facilitators of clinical nutrition services (CNS), especially the use of oral, enteral (EN) and @entity1 ( @entity1 ) nutrition in institutional and home settings. METHODS AND STUDY DESIGN: An international survey was performed between January and December 2014 in twenty-six countries from all continents. Electronic questionnaires were distributed to 28 representatives of clinical nutrition ( @entity2 ) societies, 27 of whom responded. The questionnaire comprised questions regarding a country's economy, reimbursement for CNS, education about and the use of EN and @entity1 . RESULTS: The prevalence of @entity0 was not related to gross domestic product (GDP) at purchasing power parity (PPP) per capita (p=0.186). EN and @entity1 were used in all countries surveyed (100%), but to different extents. Reimbursement of neither EN nor @entity1 use depended on GDP, but was associated with increased use of EN and @entity1 in hospitals (p=0.035), although not evident for home or chronic care facilities. The size of GDP did not affect the use of EN (p=0.256), but it mattered for @entity1 (p=0.019). CONCLUSIONS: A worldwide survey by nutrition support societies did not find a link between national economic performance and the implementation of medical nutrition services. Reimbursement for CNS, available through health insurance systems, is a factor in effective nutrition management.

title: Health insurance or subsidy has universal advantage for management of hospital XXXX unrelated to GDP.

answer: @entity0


abstract: @entity0 @entity3 is an inflammation of the mammary glands of @entity0 and causes significant economic losses in dairy @entity0 . @entity1 is one of the microorganisms most commonly isolated. Novel agents are required in agricultural industries to prevent the development of @entity3 . The production of biofilm by Staph. aureus facilitates the adhesion of bacteria to solid surfaces and contributes to the transmission and maintenance of these bacteria. The effect of the essential oils of Syzygium aromaticum (clove; EOSA) and Cinnamomum zeylanicum (cinnamon; EOCZ) and their major components, @entity4 and @entity5 , on Staph. aureus biofilm formation on different surfaces was investigated. The results showed a significant inhibition of biofilm production by EOSA on @entity2 and stainless steel surfaces (69.4 and 63.6%, respectively). However, its major component, @entity4 , was less effective on @entity2 and stainless steel (52.8 and 19.6%, respectively). Both EOCZ and its major component, @entity5 , significantly reduced biofilm formation on @entity2 (74.7 and 69.6%, respectively) and on stainless steel surfaces (45.3 and 44.9%, respectively). These findings suggest that EOSA, EOCZ, and @entity5 may be considered for applications such as sanitization in the food industry.

title: Effect of essential oils of Syzygium aromaticum and Cinnamomum zeylanicum and their major components on biofilm production in @entity1 strains isolated from milk of @entity0 with XXXX .

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) is a locally infiltrating soft-tissue @entity1 . In a population-based study in the Netherlands, we evaluated time trends for the incidence and treatment of @entity3 . METHODS: In PALGA: Dutch Pathology Registry, all @entity0 diagnosed between 1993 and 2013 as having extra-abdominal or abdominal wall aggressive @entity2 were identified and available pathology data of the @entity0 were evaluated. Epidemiological and treatment-related factors were analyzed with    (2)and regression analysis. RESULTS: During the study period, 1134 @entity0 were identified. The incidence increased from 2.10 to 5.36 per million @entity0 per year. Median age at the time of diagnosis increased annually by B 0.285 (P  =  0.001). Female gender prevailed and increased over time [annual odds ratio (OR) 1.022; P  =  0.058]. All anatomic localizations, but in particular truncal @entity1 , became more frequent. During the study period diagnostic histological biopsies were performed more often (annual OR 1.096; P  <  0.001). The proportion of @entity0 who underwent surgical treatment decreased (annual OR 0.928; P  <  0.001). When resection was preceded by biopsy, 49.8  % of the @entity0 had R0-resection versus 30.7  % in @entity0 without biopsy (P  <  0.001). CONCLUSIONS: In this population-based study, an increasing incidence of extra-abdominal and abdominal-wall aggressive @entity2 was observed. The workup of @entity0 improved and a trend towards a nonsurgical treatment policy was observed.

title: Time Trends in the Incidence and Treatment of Extra-Abdominal and XXXX : A Population-Based Study.

answer: @entity3


abstract: PURPOSE: The aim of this study was to determine the relationship between donor tissue characteristics and surgical outcomes in @entity0 with @entity3 ( @entity3 ) 2 years after undergoing Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: A retrospective chart review was performed identifying 70 eyes with @entity3 that underwent DSAEK. Donor @entity2 ( @entity2 ), donor @entity1 to preservation time, donor storage time, donor age, and postoperative recipient @entity2 were evaluated. Statistical analysis was performed using univariate linear regression analysis and bidirectional elimination multiple stepwise linear regression. RESULTS: Cornea donor age was a predictor of postoperative @entity2 at postoperative years 1 and 2 (P = 0.02, adjusted R = 0.07 and P = 0.002, adjusted R = 0.13, respectively). Donor age was also a predictor of postoperative @entity2 at years 1 and 2 after taking into account donor @entity2 , @entity1 to preservation time, and donor storage time (P = 0.02, adjusted R = 0.62 and P = 0.002, adjusted R = 0.12, respectively). Donor @entity1 to preservation time was a predictor of postoperative @entity2 at only postoperative year 2 (P = 0.03, adjusted R = 0.05). Donor storage time and donor @entity2 did not significantly impact postoperative @entity2 . CONCLUSIONS: Although donor age seems to have a statistically significant impact on postoperative @entity2 in @entity0 with @entity3 undergoing DSAEK, the relationship is weak. Other donor parameters did not have a consistent or significant impact on postoperative @entity2 .

title: Impact of donor characteristics on 2-year descemet stripping automated endothelial keratoplasty outcomes in @entity0 with XXXX .

answer: @entity3


abstract: OBJECTIVE: @entity1 -modified albumin (IMA), a novel biochemical marker, is known to reflect @entity1 in early phases of @entity3 ( @entity3 ). In the present study, we evaluated the role of IMA on the prediction of @entity2 burden and @entity1 burden in @entity0 with non-ST-segment-elevation @entity3 (NSTEACS). @entity0 AND METHODS: Ninety-six consecutive NSTEACS @entity0 presented within the first three hours of symptom onset were prospectively enrolled in this study. Blood samples were collected in the first 30 min of admission for IMA measurement. Serum levels of IMA were analyzed using the rapid and colorimetric method and reported in absorbance units (ABSU). Coronary plaque burden was assessed by using angiographic Gensini score (GS). In addition, @entity0 were divided into large (LIBG) and small @entity1 burden (SIBG) groups based on angiography findings. RESULTS: @entity0 were dichotomized into two groups according to median GS as follows; with GS <=  44 and GS > 44, respectively. Mean IMA was significantly higher in GS > 44 group as compared to GS <=  44 group (0.746    0.15 vs. 0.550    0.12 ABSU, p < 0.001). The GS was positively correlated with the levels of IMA (r = 0.673, p < 0.001). IMA was significantly higher in LIBG as compared to SIBG (0.745    0.16 vs. 0.570    0.13 ABSU, p < 0.001). CONCLUSIONS: IMA measurement in early phases of NSTEACS may give predictive information about @entity1 burden and @entity2 burden; thus, may be useful in decision-making about treatment options in these @entity0 .

title: Association between the plasma levels of IMA and @entity2 burden and XXXX burden in early phase of non-ST-segment-elevation @entity3 .

answer: @entity1


abstract: The purpose of this study was to evaluate the use of a broad panel of antibodies used as diagnostic markers for @entity2 in uterine @entity1 . The expression of @entity8 , @entity5 / @entity6 , @entity15 ( @entity15 ), @entity12 , h-caldesmon, actin, @entity18 , @entity11 , @entity9 , @entity3 , @entity13 , factor VIII, HMB-45, and @entity10 protein was studied in 397 uterine @entity1 . @entity15 was positive in 90% of the @entity7 and when combined with @entity12 or h-caldesmon, a positivity of 96% and 92%, respectively, was achieved. Actin and @entity18 were positive in 4 of 5 @entity4 . @entity16 reacted positive with @entity11 in 62 of 84 @entity0 and negative with h-caldesmon in 75 of 84 @entity0 . @entity11 was the most frequent positive marker in @entity17 . Most @entity0 markers stained negative in undifferentiated uterine @entity1 , but 12 of 21 @entity0 reacted positive for @entity15 . A few focally HMB-45-positive cells were found within all @entity0 groups, except in @entity4 and @entity14 . Endothelial markers, @entity10 protein, and @entity13 do not seem to be of any diagnostic value in uterine @entity1 . In conclusion, when immunohistochemistry is used diagnostically in uterine @entity1 , a broad panel of markers provides better information than reliance on a single antibody.

title: Diagnostic immunohistochemistry in uterine XXXX : a study of 397 cases.

answer: @entity1


abstract: OBJECTIVE: To report a case of drug-induced @entity2 associated with @entity9 treatment in a @entity0 with @entity6 . CASE SUMMARY: A 52-year-old @entity0 with @entity17 presented to the emergency department with a 1-day history of @entity2 (temperature 39.9   C), chills, @entity7 , and @entity8 . One week earlier, @entity9 50 mg/day had been started for worsening @entity10 . The @entity0 was admitted and evaluated for acute infectious processes. All of his home medications ( @entity15 , @entity3 , @entity13 / @entity19 , @entity14 , @entity18 , @entity11 , @entity16 , @entity12 ), except @entity3 , were held. Results of chest X-ray, viral cultures, and urine and blood cultures revealed no source of @entity4 . The @entity0 's temperature returned to normal within 30 hours after discontinuation of @entity9 ; rechallenge was not performed. DISCUSSION: Fever as an adverse drug reaction is often unrecognized, particularly in medically complex @entity0 . @entity9 has been reported to cause @entity2 in @entity0 with @entity1 and in those with @entity5 ; to our knowledge, there have been no previous reports documenting @entity9 -induced @entity2 in @entity0 with @entity6 . The chronological course of febrile response and defervescence is highly suggestive of drug-induced @entity2 . CONCLUSIONS: The rapid resolution of @entity2 after discontinuation of @entity9 suggests that it was the likely source of @entity2 in this @entity0 . If @entity9 is increasingly prescribed in @entity0 with @entity6 , @entity2 as an adverse reaction may become more common.

title: @entity9 -induced @entity2 in XXXX .

answer: @entity6


abstract: BACKGROUND: In @entity0 with a @entity1 , video-assisted thoracic surgery (VATS) is considered to be associated with more postoperative advantages compared to open procedures. However, open procedures are still preferred in cases with large or @entity1 . Therefore, in order to determine the appropriate surgical strategies for resection of @entity2 , we here review our experience with such cases. METHODS: Between January 2000 and February 2014, we experienced 132 @entity0 diagnosed with mediastinal @entity2 . By using data from a retrospective review of the @entity0 ' medical records, we compared the demographic characteristics, hospital stay duration, chest tube indwelling time, operative time, and mass size of the VATS group with those of the @entity0 in the open group. Moreover, we also analyzed the @entity3 and recurrence. Finally, based on our findings, we created a '   V (volume of the mass-volume of the cyst in the mass)' capable of determining the appropriate surgical strategy, measured by preoperative computed tomography scan. RESULTS: We excised the mass using VATS in 79 @entity0 , while 53 @entity0 underwent open procedures, including thoracotomy (n  =  10) and median sternotomy (n  =  43). The operative times, the hospital stay duration, and the chest tube indwelling time were significantly shorter in the VATS group compared to in the open group (Table  1). Four cases were converted to thoracotomy. The mean mass sizes were 6.53      2.20  cm and 8.58      3.45  cm in the VATS and open groups, respectively. The '   V' of the VATS group was higher than that of the open group. There were three @entity3 . Table  1 Comparison of the perioperative variables between the VATS group and open groups VATS (n  =  79) Open (n  =  53) p value Preoperative variables Age (years) 32.34          13.44 29.30      14.76 0.223 Female 63 28 0.001 BMI 22.07      3.34 22.59      3.91 0.409 ASA class 0.272 Class 1 39 21 Class 2 40 32 Mass size (cm) 6.53      2.20 8.58      3.45 <0.001    V (cm(3)) 988.15      1590.85 3093.22      4947.33 0.001 Intraoperative variable Operative time (min) 129      46 170      45 <0.001 Postoperative variable Hospitalization (days) 6.00      3.03 8.94      3.99 <0.001 ICU stay (days) 0 0.42      0.50 <0.001 CTD time (days) 2.00      1.24 3.8      3.63 <0.001 Median F/U duration (months) 47.16      43.60 27.52      34.00 The data are presented as mean      standard deviation VATS video-assisted thoracic surgery, CTD chest tube indwelling CONCLUSION: VATS for mediastinal @entity2 can be performed safely in selected @entity0 with large or malignant masses. The proposed '   V' appears to be a useful method for determining the appropriate surgical strategy in the large size @entity2 cases.

title: Clinical results of surgical resection of mediastinal XXXX : efficacy of video-assisted thoracic surgery.

answer: @entity2


abstract: UNASSIGNED: For @entity6 associated with @entity3 , surgical treatment is often advocated. However, the safety and efficacy of single-stage intraspinal mass resection and @entity6 correction remain unclear. The purpose of this study was to retrospectively evaluate the feasibility and risk factors of single-stage surgical treatment for @entity6 associated with intraspinal mass. @entity0 ' clinical records were reviewed for demographic and radiographic data, operating time, intraoperative @entity4 , perioperative complications, and postoperative pathologic results. Two female and 5 male @entity0 with an average age of 19.14        7.52 years (range, 11-31 years) were evaluated. @entity0 were followed for a minimum of 24 months after initial surgical treatment, with an average of 49.71        32.90 months (range, 27-99 months). Spinal curvature was corrected from an average of 69.57        20.44   to 29.14        9.87  , demonstrating a mean correction rate of 55.05%        18.75%. No obvious loss of correction was observed at the final follow-up. Complications included transient @entity2 , @entity7 , and intraspinal mass recurrence in 1 @entity0 each. There was no @entity5 or permanent @entity1 . In conclusion, simultaneous intraspinal mass resection and @entity6 correction appears to be safe and effective.

title: Safety and Efficacy of Single-Stage Surgical Treatment for XXXX Associated with Intraspinal Mass.

answer: @entity6


abstract: PURPOSE: Large infusion of crystalloids may induce acid-base alterations according to their strong ion difference ([ @entity5 ]). We wanted to prove in vivo, at constant PCO(2), that if the [ @entity5 ] of the infused crystalloid is equal to baseline plasma @entity3 , the arterial pH remains unchanged, if lower it decreases, and if higher it increases. METHODS: In 12 @entity1 , anesthetized and mechanically ventilated at PCO(2)    40 mmHg, 2.2 l of crystalloids with a [ @entity5 ] similar to (lactated Ringer's 28.3 mEq/l), lower than (normal saline 0 mEq/l), and greater than (rehydrating III 55 mEq/l) baseline @entity3 (29.22    2.72 mEq/l) were infused for 120 min in randomized sequence. Four hours of wash-out were allowed between the infusions. Every 30 min up to minute 120 we measured blood gases, plasma electrolytes, urinary volume, pH, and electrolytes. Albumin, hemoglobin, and @entity4 were measured at time 0 and 120 min. RESULTS: Lactated Ringer's maintained arterial pH unchanged (from 7.47    0.06 to 7.47    0.03) despite a plasma dilution around 12%. Normal saline caused a reduction in pH (from 7.49    0.03 to 7.42    0.04) and rehydrating III induced an increase in pH (from 7.46    0.05 to 7.49    0.04). The kidney reacted to the infusion, minimizing the acid-base alterations, by increasing/decreasing the urinary anion gap, primarily by changing @entity0 and @entity2 concentrations. Lower urine volume after normal saline infusion was possibly due to its greater osmolarity and @entity2 concentration as compared to the other solutions. CONCLUSIONS: Results support the hypothesis that at constant PCO(2), pH changes are predictable from the difference between the [ @entity5 ] of the infused solution and baseline plasma @entity3 concentration.

title: In vivo conditioning of acid-base equilibrium by crystalloid solutions: an experimental study on XXXX .

answer: @entity1


abstract: @entity0 muscles lacking both mitochondrial ( @entity4 ) and cytoplasmic (MM-CK) @entity2 kinase (CK-/-) show depressed mechanical performance in association with low muscle @entity1 and enhanced @entity3 content. The aims of the present study were to elucidate the possible role of low @entity1 and high @entity3 content in impairment of mechanical performance in CK-/- @entity0 and to establish whether CK-/- muscles are able to sustain repeated series of high-intensity contractions. The dorsal flexors of CK-/- and control @entity0 were subjected in situ to two series of 12 tetanic contractions using a custom-made @entity0 isometric dynamometer. The muscle content of high-energy phosphates was analysed by HPLC. @entity1 content declined from 20.6+/-1.9 to 15.5+/-2.4 micromol x g(-1) dry weight (d.w.); @entity3 content increased from 1.2+/-0.4 to 2.4+/-1.1 micromol x g(-1) d.w. during the first contraction series in CK-/- muscle. Despite these unfavourable changes, maximal torque developed during the first contraction of either series did not differ, indicating that the altered content of @entity1 and @entity3 does not play a decisive role in impaired mechanical performance in CK-/- @entity0 . The relative decline in torque during the two series did not differ in CK-/- (-20.4+/-6.6 vs. -23.8+/-9.9%). In contrast, wild-type (WT) muscles showed a significantly more pronounced decline during the second series (-12.3+/-7.4 vs. -20.1+/-6.8%). Muscle @entity1 and @entity3 content did not change in CK-/-, whereas in WT @entity3 content increased significantly during the second contraction series. These findings indicate that CK-/- tolerate repeated series of high-intensity contractions better than WT, while in CK-/- muscle an additional source of energy is mobilised to regenerate @entity1 during the second series.

title: XXXX muscles deficient in @entity2 kinase tolerate repeated series of high-intensity contractions.

answer: @entity0


abstract: BACKGROUND: The efficacy and safety of @entity12 , a potent and selective vascular endothelial growth factor receptors 1-3 inhibitor, combined with best supportive care (BSC) was evaluated in a global, randomized, placebo-controlled phase II trial in @entity0 with locally advanced or metastatic @entity4 ( @entity4 ). @entity0 AND METHODS: @entity0 with @entity4 and @entity0 -Pugh Class A who progressed on or were intolerant to one prior antiangiogenic therapy were stratified by @entity1 invasion (presence/absence of extrahepatic spread and/or vascular invasion) and region (Asian/non-Asian) and randomized (2:1) to @entity12 /BSC (starting dose 5 mg twice-daily) or placebo/BSC. The primary end point was @entity9 ( @entity9 ). RESULTS: The estimated hazard ratio for @entity9 was 0.907 [95% confidence interval (CI) 0.646-1.274; one-sided stratified P = 0.287] for @entity12 /BSC (n = 134) versus placebo/BSC (n = 68), with the median (95% CI) of 12.7 (10.2-14.9) versus 9.7 (5.9-11.8) months, respectively. Results of prespecified subgroup analyses in Asian versus non-Asian @entity0 or presence versus absence of @entity1 invasion were consistent with the overall population. Improvements favouring @entity12 /BSC (P < 0.01) were observed in secondary efficacy end point analyses [progression-free survival (PFS), time @entity1 ( @entity1 ), and clinical benefit rate (CBR)], and were retained among Asian @entity0 in the prespecified subgroup analyses. Overall response rate did not differ significantly between treatments and @entity0 -reported outcomes favoured placebo/BSC. Most common all-causality adverse events with @entity12 /BSC were @entity5 (54%), @entity2 (54%), and decreased appetite (47%). Baseline serum analyses identified potential new prognostic ( @entity6 , @entity11 , @entity7 , @entity8 , migration inhibitory factor, and @entity10 ) or predictive ( @entity11 and stromal-derived factor-1) factors for survival. CONCLUSIONS: @entity12 /BSC did not improve @entity9 over placebo/BSC in the overall population or in stratification subgroups. However, @entity12 /BSC resulted in significantly longer PFS and @entity1 and higher CBR, with acceptable @entity3 in @entity0 with advanced @entity4 . TRIAL REGISTRATION: ClinicalTrials.gov, NCT01210495.

title: Randomized phase II study of @entity12 versus placebo plus best supportive care in second-line treatment of advanced XXXX .

answer: @entity4


abstract: BACKGROUND: @entity2 is a rare extranodal presentation of @entity3 . The authors report long term follow-up information regarding a group of @entity0 with @entity2 evaluated at the Mayo Clinic and describe the outcome with special attention to patterns of recurrence. METHODS: The medical records of @entity0 with @entity2 seen at the Mayo Clinic between January 1970 and March 1993 were reviewed. @entity0 were included if they had evidence of testicular involvement at the time of diagnosis of @entity2 . Pathology specimens were reviewed for confirmation of diagnosis. RESULTS: Sixty-two @entity0 with a diagnosis of @entity2 were identified. Their median age was 68 years, and 60 @entity0 underwent orchiectomy as the initial therapeutic and diagnostic procedure. Most of @entity0 (79%) had localized or regional disease at the time of presentation. Other treatment modalities after diagnosis included radiotherapy (37%), combination chemotherapy (37%), and combination chemotherapy and radiotherapy (16%). Although 88% of @entity0 had no @entity1 after primary treatment, 80% subsequently experienced disease recurrence. There was no significant difference in the rate of recurrence, including Ann Arbor Stage I disease. Treatment did not appear to affect the recurrence rate. At a median follow-up of 2.7 years, 60% of @entity0 had died of disease. Late recurrences were observed, and there appeared to be no plateau in the disease free survival curve. In half (51%) of the @entity0 with disease recurrence, only extranodal locations were involved. Thirteen @entity0 experienced recurrence in the central nervous system, 11 of whom had parenchymal lesions. In 8 of these 13 @entity0 , the central nervous system was an isolated site of disease recurrence. CONCLUSIONS: @entity2 is a unique and aggressive extranodal @entity3 . Better treatment strategies are needed to prevent recurrences. The risk of extranodal recurrence is high, especially in the central nervous system.

title: XXXX is associated with a high incidence of extranodal recurrence.

answer: @entity2


abstract: A wide variety of architectural patterns of @entity3 may be seen in the prostate. We have recently encountered a hitherto-undescribed pattern of growth characterized by @entity5 of @entity0 cells reminiscent of renal glomeruli, which we refer to as @entity2 with glomeruloid features. To define the architectural features, frequency, and distribution of @entity2 with glomeruloid features, we reviewed 202 totally embedded radical prostatectomy specimens obtained between October 1992 and April 1994 from the files of the Mayo Clinic. This series was supplemented by 100 consecutive needle biopsies with @entity2 from January to February 1996. @entity2 with glomeruloid features was characterized by round to oval epithelial tufts growing within malignant acini, often supported by a fibrovascular core. The epithelial cells were sometimes arranged in semicircular concentric rows separated by clefted spaces. In the radical prostatectomy specimens, nine cases (4.5%) had glomeruloid features. The glomeruloid pattern constituted 5% to 20% of each @entity0 (mean, 8.33%) and was usually located at the apex or in the peripheral zone of the prostate. Seven cases were associated with a high Gleason score (7 or 8), one with a score of 6, and one with a score of 5. All cases were associated with high-grade @entity6 and extensive perineural invasion. Pathological stages included T2c (three cases), T3b (four cases), and T3c (two cases); one of the T3b cases had lymph node metastases (N1). Three (3%) of 100 consecutive routine needle biopsy specimens with @entity0 showed glomeruloid features, and this pattern constituted 5% to 10% of each @entity0 (mean, 6.7%). The Gleason score was 6 for two cases and 8 for one case. Two cases were associated with high-grade @entity6 , and one case had perineural invasion. Glomeruloid features were not observed in any benign or @entity1 , including @entity4 and @entity6 . Glomeruloid structures in the prostate represent an uncommon but distinctive pattern of growth that is specific for @entity0 . Glomeruloid features may be a useful diagnostic clue for @entity0 , particularly in some challenging needle biopsy specimens. This pattern of growth is usually seen in high-grade @entity3 , often with extraprostatic extension. Further investigations are required to determine its independent predictive value and correlation with stage and Gleason score.

title: XXXX with glomeruloid features.

answer: @entity2


abstract: BACKGROUND AND IMPORTANCE: his is the first case report of clipping a @entity3 in a @entity0 with @entity11 ( @entity11 ). @entity11 is a newly described autosomal dominant connective tissue disease with systemic vascular involvement. Unique to this syndrome is the development of @entity4 at a young age with the propensity of dissection or @entity2 at a stage that is earlier than when surgical intervention is typically indicated. We describe the nuances in intraoperative and postoperative management. CLINICAL PRESENTATION: A 31-year-old @entity0 who recently received a diagnosis of with @entity11 type II presented to neurosurgical attention for management of an unruptured right ophthalmic @entity3 . The @entity0 underwent a right pterional craniotomy for clipping of the @entity4 , with lumbar drain placement before the procedure. @entity10 had to be used several times to counteract @entity9 of the vessels during arachnoid dissection. Because of vascular reactivity, temporary clipping was not used, and the @entity4 was clipped successfully. CONCLUSION: @entity11 is a newly described disorder that warrants awareness in the neurosurgical community because of its association with @entity4 as well as @entity1 (19%), @entity7 (20%), cervical spine instability (7%), @entity6 , and @entity8 . When clipping @entity4 in these @entity0 , the surgeon should be aware of the potential for severe vascular reactivity during dissection and avoid temporary clipping when possible. Avoidance of lumbar drainage intraoperatively reduces the risk of @entity5 after removal.

title: Clipping of a @entity3 in a @entity0 with XXXX : case report.

answer: @entity11


abstract: BACKGROUND: The reliability of clinical tests for the cervical spine has not been adequately evaluated. Six cervical clinical tests, which are low cost and easy to perform in clinical settings, were tested for intra- and inter-examiner reliability, and two performance tests were assessed for test-retest reliability in @entity0 with and without @entity4 . Moreover, construct and between-group discriminative validity of the tests were examined. METHODS: Twenty-one @entity0 with @entity4 and 21 asymptomatic @entity0 were included. Intra- and inter-reliability were evaluated for the Cranio-Cervical Flexion Test (CCFT), Range of Movement (ROM), Joint Position Error (JPE), @entity2 ( @entity2 ), Smooth Pursuit Neck Torsion Test (SPNTT), and neuromuscular control of the Deep Cervical Extensors (DCE). Test-retest reliability was assessed for Postural Control (SWAY) and Pressure @entity1 Threshold ( @entity3 ) over tibialis anterior, infraspinatus and the C3-C4 segment. RESULTS: Intraclass Correlation Coefficient (ICC) for intra- and inter-examiner reliability was highest for ROM (range: 0.80 to 0.94), @entity5 (0.75 to 0.90) and CCFT (0.63 to 0.86). JPE had the lowest ICC (0.02 to 0.66). Intra- and inter-reliability for @entity2 and SPNTT showed kappa ranging from 0.66 to 0.92, and 0.57 to 0.78 (prevalence adjusted), respectively. For the test-retest study, ICC was 0.83 to 0.89 for @entity3 and 0.39 to 0.79 for SWAY. Construct validity was satisfactory for all tests, except JPE. Significant between group discriminative validity was found for CCFT, ROM, @entity2 , SPNTT and @entity3 , however, differences were within the limits of the minimal detectable change. CONCLUSIONS: The majority of the tests evaluated showed satisfactory reliability and construct validity supporting their use in the clinical evaluation of @entity0 with @entity4 .

title: Reliability, construct and discriminative validity of clinical testing in subjects with and without XXXX .

answer: @entity4


abstract: OBJECTIVE: Most controlled studies comparing second-generation and conventional antipsychotics have focused on the acute treatment of @entity2 . The authors compared symptom outcomes, side effects, and social adjustment in stable @entity2 outpatients who received 2 years of maintenance treatment with @entity6 or @entity7 . METHOD: This was a 2-year, randomized, double-blind comparison of 6 mg of @entity6 versus @entity7 in 63 @entity0 with stabilized DSM-IV @entity2 . Study @entity0 also received 15 months of standard behavioral skills training or enhanced training with a case manager who promoted @entity0 ' use of their skills in the community. RESULTS: The risk of @entity5 exacerbations and the risk of leaving the study were similar for both drug treatment groups. However, @entity0 who received both @entity6 and the enhanced community-based skills training were more likely to remain in the study than those in the other treatment groups. @entity0 demonstrated significant improvement in score on the Brief Psychiatric Rating Scale over time with both medications. There were no between-group differences in cluster scores for thought disturbance, hostile-suspiciousness, and @entity9 . A significant between-group difference favoring @entity6 was found for the @entity3 cluster. @entity6 resulted in significantly greater reductions in @entity4 and @entity8 and greater improvements in most items on the SCL-90-R. CONCLUSIONS: When compared with @entity0 given a low dose of @entity7 , @entity6 -treated @entity0 experienced similar improvements in positive and negative symptoms and similar risks of @entity5 exacerbations. However, @entity6 -treated @entity0 appeared to feel subjectively better, as indicated by less @entity1 and @entity3 and fewer extrapyramidal side effects.

title: Maintenance treatment of XXXX with @entity6 or @entity7 : 2-year outcomes.

answer: @entity2


abstract: OBJECTIVES: The purpose of this work was to examine the indications for the combined transfacial and neurosurgical @entity1 . @entity0 AND METHODS: Fifteen @entity0 with @entity1 underwent surgery via the combined approach between 1990 and 2000 at the Amiens University Hospital. The transfacial approach alone was reserved for elderly @entity0 . RESULTS: The histological diagnosis was @entity3 in 10 @entity0 . There was one @entity2 . Mean follow-up was 45 months (range 3 - 129). Six @entity0 died from local or metastatic recurrence. At last follow-up eight @entity0 were disease free, two had local or metastatic recurrence. CONCLUSION: We compared systematic use of the combined approach for curative surgery with surgical strategies adopted by other teams. The combined approach is indicated for T3 or T4 @entity1 and for all other @entity1 with a posterior or superior extension. @entity1 may be treated with the transfacial access alone. @entity1 without extension to the orbit or cribiform plate may be managed endoscopically. The role of histological diagnosis and the choice of the surgical approach remain to be evaluated.

title: [Combined transfacial and neurosurgical approach for the treatment of XXXX ].

answer: @entity1


abstract: This study investigated the effect of @entity1 at @entity2 on the semen quality and the serum reproductive hormone levels in male adults. A total of 52 male soldiers were enrolled in this cohort study. They were exposed to @entity1 at @entity2 (5380   m) for 12 months when undergoing a service. After exposure, they were followed up for 6 months. The samples of semen and peripheral blood were collected at 1 month before exposure (M0), 6 months of exposure (M6), 12 months of exposure (M12), and 6 months after exposure (M18). The semen quality was assessed with computer-assisted analysis system, and the serum levels of reproductive hormones, including prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and @entity0 were analyzed by ELISA. Compared with those at M0, total sperm count, sperm density, motility, survival rate, and serum levels of LH, PRL and @entity0 were significantly decreased, whereas the liquefaction time was significantly prolonged and serum FSH level was significantly increased at M6 (p<0.05). At M12, total sperm count and sperm density increased, whereas sperm motility, survival rate, and the liquefaction time further decreased. Sperm velocities, progression ratios, and lateral head displacements were also decreased. Serum FSH level decreased while serum LH, PRL, and @entity0 levels increased. Compared with those at M6, the changes in these detected parameters of semen and hormone at M12 were significant (p<0.05). At M18, all these detected parameters except @entity0 level returned to levels comparable to those before exposure. In conclusion, @entity1 at @entity2 causes adverse effects on semen quality and reproductive hormones, and these effects are reversible.

title: Exposure to XXXX at High Altitude (5380   m) for 1 Year Induces Reversible Effects on Semen Quality and Serum Reproductive Hormone Levels in Young Male Adults.

answer: @entity1


abstract: The cyclooxygenase (COX)-2 selective inhibitors @entity9 and @entity10 have been found to be more effective than placebo and comparably effective to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of @entity0 with @entity3 and @entity2 . Two large outcome studies, the Celecoxib Long-term @entity5 Safety Study (CLASS) and Vioxx Gastrointestinal Outcomes Research (VIGOR) trial, were conducted to test the hypothesis that @entity0 receiving a @entity8 selective inhibitor would have significantly fewer clinically important upper gastrointestinal events than @entity0 taking nonselective NSAIDs. This article critically reviews the design and results of these trials. Both trials found that @entity5 @entity0 not taking low-dose @entity1 (325 mg/day or less) who were randomized to receive @entity8 selective inhibitors had significantly fewer symptomatic and complicated @entity7 than @entity0 randomized to nonselective NSAIDs. A significant risk reduction was not demonstrated, however, in @entity0 in the CLASS trial who were taking low-dose @entity1 , itself an independent risk factor for the endpoint. These data validate the @entity8 hypothesis and support recommendations that a @entity8 selective inhibitor should be used in the treatment of @entity0 at increased risk for symptomatic and complicated @entity7 . Further studies are needed to determine whether @entity8 selective inhibitors are safer than nonselective NSAIDs when used in @entity0 receiving low-dose @entity1 . The @entity8 selective inhibitors have a similar profile of renal adverse events to nonselective NSAIDs. The increased rate of cardiovascular @entity6 adverse events among @entity0 randomized to @entity10 compared to those randomized to naproxen in the VIGOR trial is consistent with the lack of an anti-platelet effect for this @entity8 selective inhibitor. This emphasizes the need for the use of low-dose @entity1 in @entity0 at risk for such events, especially @entity4 .

title: What have we learned from the large outcomes trials of XXXX selective inhibitors? The rheumatologist's perspective.

answer: @entity8


abstract: The role of high-dose chemotherapy (HDCT) in @entity1 with refractory @entity0 is not well established. Forty-two female @entity1 (median age of 46 years) with @entity0 refractory to neoadjuvant chemotherapy received HDCT ( @entity2 , @entity4 and @entity5 ) supported by an autologous peripheral blood stem cells transplant. Their disease had been refractory (defined as less than partial response) to one (18 @entity1 ) or two (24 @entity1 ) regimens of neoadjuvant chemotherapy. Twenty-nine @entity1 had surgery before HDCT. The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. Thirty @entity1 had complete remission, eight had a PR, one had a minor response, and three had progressive disease. In seven of 13 @entity1 whose disease was inoperable before HDCT, it became operable. After a median follow-up of 42 months, 21 @entity1 were alive, and 15 remained disease free. Five-year @entity3 ( @entity3 ) was 57% (CI, 50-64%), and the estimated 5-year progression-free survival was 40% (CI, 32-48%). Both @entity3 and PFS were better in @entity1 whose disease became operable after chemotherapy than in those whose disease remained inoperable. A randomized study is warranted in this @entity1 population.

title: High-dose chemotherapy and autologous peripheral blood stem cell transplantation for primary XXXX refractory to neoadjuvant chemotherapy.

answer: @entity0


abstract: UNASSIGNED: Thirty-four subjects with symptomatic @entity7 ( @entity7 ) or critical limb ischmeia (CLI) who were experiencing @entity4 , @entity3 resting @entity4 , @entity6 , and @entity1 lower leg/foot ulceration were randomized into 2 treatment groups. MATERIALS AND METHODS: Eighteen of these @entity0 received treatment with @entity2 ( @entity2 ) 60 minutes twice daily for 16 weeks, and 16 subjects received standard care consisting of an exercise regimen of walking for 20 minutes twice daily for 16 weeks. The @entity2 device delivers bilateral pressures of 120 mm Hg. Cycle times provide sequential compression for 4 seconds (+/- 0.5 seconds) followed by a 16-second rest period (+/- 3.0 seconds), resulting in a 20-second cycle or 3 cycles per minute. The study was designed to measure @entity0 -centered outcomes. The primary endpoint was @entity9 ( @entity9 ), defined as time to maximally tolerated @entity4 . Secondary endpoints included change in resting ankle brachial index, @entity5 , relief of resting/wound @entity4 , and quality of life (QoL) index. Age (73.7 years vs 72.7 years), baseline PWTs (1-6 minutes), and risk factors were similar in both treatment groups. RESULTS: At 4 weeks, the percent change from baseline in @entity9 did not vary significantly between treatment groups (17.8% for @entity2 and 17% for standard care). After 8 weeks, the percent change in @entity9 for the @entity2 group was 41% compared to 32% for the group receiving standard care (P = 0.062). At the 16-week time point the percent change from baseline in @entity9 was significantly different between treatment arms (35.5% for the standard care group and 54.7% for the group receiving @entity2 [P = 0.043]). The mean reduction in wound surface area was 57% and 71% at 12 weeks and 16 weeks, respectively, for the @entity2 group, compared to 45% and 56% for the control group. The @entity2 group reported significantly greater @entity4 relief at the 12-week (P = 0.044) and 16- week (P = 0.038) time points. Compared to the control group, the @entity2 group reported improvement in @entity0 -centered outcomes such as physical function and @entity4 . These differences were statistically significant (P less than 0.05) at the 16- week evaluation period. CONCLUSION: Therapy consisting of @entity2 for 2 hours daily for a period of 16 weeks significantly improved @entity9 , reduced resting @entity4 , and improved healing rates, physical function, and @entity4 . There were no devicerelated complications, allowing for long-term use. This study further supports that @entity2 is safe and effective and should be considered for @entity0 who are not candidates for endovascular or surgical procedures. Furthermore, @entity2 offers an excellent alternative for the palliative care of @entity0 with @entity7 and @entity8 .

title: Effect of High-pressure, Intermittent Pneumatic Compression for the Treatment of @entity7 and @entity1 in XXXX Without a Surgical Option.

answer: @entity0


abstract: @entity5 ( @entity5 ) with the da Vinci Surgical System has been used for the removal of pharyngeal and @entity1 with the objective to improve functional and aesthetic outcomes without worsening survival. While @entity5 has been approved in many countries, Japan's FDA has not yet done so. Our hospital started using @entity5 with the approval of the Ethical Review Board and the Minimum Invasive Surgical Center Committee at Tottori University. No surgical outcomes of @entity5 for Japanese @entity0 with @entity2 have been reported in Japan. This paper deals with the outcomes and feasibility of @entity5 for Japanese @entity0 with @entity1 at our institution. @entity5 was performed for 10 @entity0 with T1, T2, T3 oropharyngeal and @entity4 between 2013 and 2014. This is a single-institutional study. @entity5 could be completed for all cases, except one @entity0 that was not candidate, and no intraoperative conversion to an open surgical procedure was required. Five @entity0 underwent neck dissection, two of them concurrent and three staged. Of all @entity0 , positive surgical margins were detected in two. The average @entity3 including neck dissection was 21.5      33.4  ml, the operation time was 183      36  min and the console time was 103      22  min. No tracheostomy had been performed either pre- or postoperatively, and there was no difference between preoperative and postoperative swallowing functions. In this single-institutional preliminary study, we demonstrated that @entity5 is a feasible and safe treatment. A clinical multi-institutional study of @entity5 for @entity1 has been approved as an advanced medical system study and is under way. In the near future, it is expected that the efficacy and safety of @entity5 for @entity1 will be confirmed as the result of this multiple-institutional clinical study in Japan.

title: Preliminary study of transoral robotic surgery for XXXX in Japan.

answer: @entity1


abstract: INTRODUCTION: @entity3 between @entity1 ( @entity4 ) and @entity2 ( @entity2 ) is important but under-recognised. We aimed to determine the prevalence of @entity3 and the predictors of @entity4 in @entity0 with @entity2 . METHODS: @entity0 aged >=  40 years were recruited from a dedicated @entity2 clinic and underwent overnight polysomnography. A diagnosis of @entity4 was made when apnoea-hypopnoea index (AHI) was >=  5. RESULTS: In all, 22 @entity0 (aged 71    9 years), predominantly @entity0 , were recruited. Mean values recorded were: predicted forced expiratory volume in the first second percentage 55    15; body mass index 23.7    6.5 kg/m2; Epworth Sleepiness Scale score 5.6    5.8; and AHI 15.8    18.6. Among the 14 @entity0 with @entity4 (prevalence of @entity3 at 63.6%), the mean number of hospital visits for @entity2 exacerbations in the preceding one year was 0.5    0.7. @entity0 with @entity3 had worse modified Medical Research Council dyspnoea scale scores and a lower percentage of rapid eye movement (REM) sleep than @entity0 without. There were no other statistical differences in lung function or sleep study indices between the two @entity0 groups. CONCLUSION: The majority of our @entity0 had @entity3 and minimal exacerbations, and were not obese or sleepy. Significant differences between @entity0 with and without @entity3 were seen in two aspects - the former was more dyspnoeic and had less REM sleep. Our findings suggest that standard clinical predictors cannot be used for @entity0 with @entity3 , and therefore, a high index of suspicion is needed.

title: @entity3 between @entity2 and XXXX in a Southeast Asian teaching hospital.

answer: @entity1


abstract: BACKGROUND: @entity0 who undergo cardiac surgery appear to be at increased risk for the development of @entity4 ( @entity4 ). The development of antibiotic-resistant infections has been associated with significantly greater hospital mortality rates compared to similar infections caused by antibiotic-sensitive pathogens. OBJECTIVES: The purpose of this study is survey of @entity10 and antibiotic resistance patterns of causative bacteria among @entity0 who underwent open heart surgery in the north of Iran during a 2-year period between September 2012 and September 2014. METHODS: In this cross-sectional study we evaluated 187 @entity0 that underwent open heart surgery with @entity4 . Demographic feature, clinical characteristics and risk factors of each @entity1 were recorded. The antibiotic susceptibility test was performed using the Minimum inhibitory concentration (MIC) method according to the standard protocol of Clinical _ Laboratory Standards Institute (CLSI). Detection of Extended-spectrum beta-lactamase (ESBL) producing bacteria was performed by the double-disk synergy (DDS) test; also @entity9 -resistant @entity5 ( @entity5 ) strains were identified by @entity5 Screen Agar. The collected data were analyzed using the SPSS software (ver. 16) and, descriptive statistics were used. RESULTS: Out Of total of 2253 hospitalized @entity0 who underwent open heart surgery, 187(5.05%) @entity0 had @entity4 . 51.9% of the @entity0 were female. The rates of @entity1 ( @entity1 ), respiratory tract @entity1 , @entity6 , @entity2 ( @entity2 ), @entity7 and @entity8 were 27.80, 25.66%, 17.64, 17.11% 8.55% and 3.20% respectively. @entity3 and @entity5 were the most causative agents of @entity4 . The rate of ESBL-producing bacteria was 14.28- 71.42% among enterobacteriaceae and the rate of @entity5 was 54.2% among @entity5 strains. All isolated Acinetobacter.spp were Multi-drug resistance (MDR). CONCLUSIONS: We showed that the rate of @entity4 among these high-risk @entity0 was in the average level. But the emergence of @entity5 and ESBL bacteria is increasing in our region.

title: Resistance Pattern of Antibiotics in @entity0 Underwent Open Heart Surgery With XXXX in North of Iran.

answer: @entity4


abstract: A total of 150 @entity0 with @entity3 media were randomly allocated to treatment with @entity1 - @entity4 ( @entity8 ) or with cefaclor. Each drug was given in a daily dosage of approximately 40 mg/kg in three divided doses for ten days. Tympanocentesis done before treatment yielded specimens that contained pneumococcus or @entity6 sp or both in 67% of specimens. Viridans group streptococci were isolated from 10% of specimens and @entity7 from 6%. @entity0 were scheduled for follow-up examinations at midtreatment, end of therapy, and at 30, 60, and 90 days. Of the 150 @entity0 , 130 were evaluable. Five of 60 @entity0 (8%) treated with cefaclor were considered therapeutic failures because of persistent purulent drainage and isolation of the original pathogen or suprainfection. There were no failures among @entity0 treated with @entity8 (P = .019). Rates of relapse, recurrent @entity3 media with effusion, and persistent @entity5 were comparable in the two groups of @entity0 . @entity9 , or loose stools, or both were significantly more common in @entity0 treated with @entity8 (34%) than in those taking cefaclor (12%), but in no case was it necessary to discontinue medication because of these mild side effects (P = .002). Cefaclor therapy was discontinued in one @entity0 because of severe @entity2 . In this study, treatment with @entity8 was superior to treatment with cefaclor in the acute phase of @entity3 media with effusion, but @entity8 produced more adverse effects. The rates of persistent @entity5 and recurrent @entity3 media with effusion were comparable with the two regimens.

title: Comparative treatment trial of @entity8 versus cefaclor for XXXX media with effusion.

answer: @entity3


abstract: AIM: To investigate behavior and cognitive performances of teenage @entity0 with @entity6 ( @entity6 ). METHODS: We enrolled 20 teenage @entity0 (12 females and 8 males) with @entity6 , followed in the @entity0 Neurology Unit of the Catholic University (Rome). @entity0 underwent a full clinical examination including behavioral and cognitive assessments (respectively, CBCL and Wechsler scales). RESULTS: All @entity0 showed @entity2 and @entity5 , mild in six cases, moderate in seven and severe in the remaining seven. Among @entity5 @entity0 visual function, particularly visuo-motor abilities resulted mostly impaired in Wechsler subtests, whereas verbal skills were relatively preserved. In contrast, a general @entity1 was observed in moderately and @entity5 @entity0 . CONCLUSIONS: Our teenage @entity0 with @entity6 compared with other series at different ages (young childhood, adulthood) suggest a progressivity of neurological and neuropsychological signs. A visuomotor default and a relative preservation of verbal skills, like what has been found in previous reports of younger @entity0 , are still evident in mildly impaired cases. Therefore, the progression over time of these cases toward a generalized impairment may be suggested, but only longitudinal studies can confirm it. There was a possible responsibility of some @entity3 in worsening the neuropsychological outcome (early @entity4 and atypical absences, as well as persistent EEG background slowness in the last 3years).

title: Cognitive-behavioral profiles in teenagers with XXXX .

answer: @entity6


abstract: Growing concern over environmental contamination has stimulated rigorous efforts to establish reliable biological monitoring assays. Methodology was developed for measuring photoinduced short- and long-term @entity1 of an important group of contaminants, @entity2 ( @entity3 ), using the luminescent bacterium @entity4 . The @entity1 of most @entity3 can be greatly enhanced on exposure of a living organism and/or the chemicals to ultraviolet (UV) radiation. There are two major mechanisms involved in photoinduced @entity1 of @entity3 : photosensitization and photomodification. In the former, production of singlet @entity0 leads to cellular damage. In the latter, photooxidation of @entity3 results in new compounds (usually oxygenated @entity3 ) that are often more toxic than their parent @entity3 . Microbial @entity1 assays were developed to measure short- and long-term photoinduced @entity1 of @entity3 . The bioassays were based on inhibition of luminescence and growth of @entity4 . The short-term assay should detect @entity1 of chemicals that are taken up rapidly and/or whose photosensitization activity is immediate. The long-term assay should identify chemicals where the rate of assimilation is slow and/or time is required for photoinduced effects to be realized. The assays were tested with 12 different @entity3 . The short-term assay did not reveal photoinduced @entity1 for any of the test chemicals. However, photoinduced @entity1 was apparent in the long-term assay, indicating that short-term assays may be opaque to this key mechanism of @entity3 @entity1 .

title: Measurement of short- and long-term XXXX of @entity2 using luminescent bacteria.

answer: @entity1


abstract: The aim of the present study was to comparatively analyse certain outcome measures of open @entity0 , stratified per grade of @entity2 and method of treatment. For this purpose, a systematic review of the English literature from 1990 until 2010 was undertaken, comprising 32 eligible articles reporting on 3060 open @entity0 . Outcome measures included rates of union progress (early union, delayed union, late union and non-union rates) and certain complication rates ( @entity1 , @entity3 and amputation rates). Statistical heterogeneity across component studies was detected with the use of Cochran chi-square and I(2) tests. In the absence of significant statistical heterogeneity a pooled estimate of effect size for each outcome/complication of interest was produced. All component studies were assigned on average a moderate quality score. Reamed tibial nails (RTNs) were associated with significantly higher odds of early union compared with unreamed tibial nails (UTNs) in IIIB @entity4 (odds ratio: 12, 95% CI: 2.4-61). Comparing RTN and UTN modes of treatment, no significant differences were documented per grade of @entity4 with respect to both delayed and late union rates. Surprisingly, nonunion rates in IIIB @entity4 treated with either @entity5 were lower than IIIA or II @entity4 , although the differences were not statistically significant. Significantly increased @entity1 rates of IIIB @entity4 compared with all other grades were documented for both modes of treatment (RTN, UTN). However, lower @entity1 rates for IIIA @entity4 treated with RTNs were recorded compared with grades I and II. Interestingly, grade II open @entity0 , treated with UTN, presented significantly greater odds for developing @entity3 than when treated with RTNs. Our cumulative analysis, providing for each grade of @entity2 and each particular method of treatment a summarised estimate of effect size for the most important outcome measures of open @entity0 , constitutes a useful tool of the practicing surgeon for optimal decision making when operative treatment of such @entity0 is contemplated.

title: Prevalence of complications of open tibial shaft XXXX stratified as per the Gustilo-Anderson classification.

answer: @entity0


abstract: Mitochondria form a dynamic network of interconnected tubes in the cells of @entity1 or filamentous fungi such as @entity6 , @entity4 , or @entity7 . The dynamics depends on the separation of mitochondrial fragments, their movement throughout the cell, and their subsequent fusion with the other parts of the organelle. Interestingly, the microtubule network is required for the distribution in @entity4 and @entity5 , while @entity1 and A. nidulans appear to use the actin cytoskeleton. We studied a homologue of @entity1 @entity8 in A. nidulans, and named it MdmB. The open reading frame is disrupted by two introns, one of which is conserved in @entity8 of @entity7 . The MdmB protein consists of 428 @entity3 with a predicted molecular mass of 46.5 kDa. MdmB shares 26% identical @entity3 to @entity8 from @entity1 , 35% to @entity4 , and 32% to the @entity7 homologue. A MdmB-GFP fusion protein co-localized evenly distributed along mitochondria. Extraction of the protein was only possible after treatment with a non-ionic and an ionic detergent (1% Triton X-100; 0.5% @entity0 ) suggesting that MdmB was tightly bound to the mitochondrial membrane fraction. Deletion of the gene in A. nidulans affected mitochondrial morphology and distribution at 20 degrees C but not at 37 degrees C. mdmB deletion cells contained two populations of mitochondria at lower temperature, the normal tubular network plus some giant, @entity2 .

title: Deletion of mdmB impairs mitochondrial distribution and morphology in XXXX .

answer: @entity6


abstract: BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is a common technique for assessing the pancreas and the biliary system; however, the potential complications have raised concern among endoscopists and @entity0 . Recently, the need of endoscopic ultrasound (EUS) as an additional tool of assessment before the ERCP procedure has been increasing. The need of EUS in developing countries is still a matter of debate regarding the cost, investment, and training. Here, we report the significant impact of EUS on several unselected interesting cases of @entity2 . METHOD: We selected several interesting cases from the @entity0 who underwent EUS at our private hospital in Jakarta, Indonesia. The EUS procedures were performed by one experienced endosonographer and one EUS trainee who are very experienced with transabdominal ultrasound. The equipment was an Olympus JF UCT 180 EUS scope which was connected to an Aloka IPF-1701C ultrasound machine (Tokyo, Japan). RESULTS: Five interesting cases were included from @entity0 who underwent EUS due to @entity2 . The cases included recurrent @entity3 due to pancreatic stone at the small branch that obstructed the main pancreatic duct, common bile duct (CBD) stone with insignificant duct dilatation, @entity3 with @entity5 at the distal CBD and portal vein infiltration, @entity3 in a young @entity0 , and distal CBD mass that @entity4 . CONCLUSIONS: The EUS procedure has shown a significant impact in managing @entity0 with @entity1 . In most developing countries, EUS needs to be evaluated further regarding the cost, investment, and training.

title: Impact of Endoscopic Ultrasound Procedures in Various XXXX in Indonesia Based on a Case Series in a Private Hospital.

answer: @entity2


abstract: BACKGROUND: Epidemic @entity6 is a highly contagious @entity2 that occurs worldwide and is caused mainly by adenoviruses and enteroviruses. An 18-year analysis of the changes of pathogens and clinical signs in a subtropical and densely populated island presents certain special features. METHODS: We retrospectively analyzed the clinical information and laboratory records of the @entity1 @entity0 with positive conjunctival swabs from 1980 to 1997. RESULTS: The positive rate of laboratory diagnosis of @entity1 was 50.0% (1,233/2,467). From 1980 to 1994, the predominant causative agent of @entity4 was adenovirus type 8 (Ad8), with six genotypes being evolved. Three of the new Ad8 genotypes each caused a new epidemic. After 1995 the predominant adenoviral pathogens shifted to Ad37 and @entity7 , and no more Ad8 was isolated. Enterovirus type 70 (EV70) was isolated from four outbreaks of @entity3 ( @entity3 ) from 1980 to 1984, but rarely in later years. @entity5 type 24 variant (CA24v), which first appeared in 1985, appeared later as the causes of four major epidemics of @entity3 from 1985 to 1994. The overall clinical symptoms of @entity6 were more severe in the 1990s than in the 1980s. CONCLUSION: In southern Taiwan, outbreaks of @entity4 caused by new genomic variants could be associated with the long-term endemic co-circulation of Ad8, @entity7 , and Ad37, while epidemics of CA24v @entity3 were caused mainly by introduction of new viral strains from neighboring countries. The aggravation of host symptoms in the 1990s needs further investigation and close follow-up.

title: The change of etiological agents and clinical signs of XXXX over an 18-year period in southern Taiwan.

answer: @entity6


abstract: BACKGROUND: Mobile technology enables high frequency mood monitoring and automated passive collection of data (e.g. actigraphy) from @entity0 more efficiently and less intrusively than has previously been possible. Such techniques are increasingly being deployed in research and clinical settings however little is known about how such approaches are experienced by @entity0 . Here, we explored the experiences of individuals with @entity2 engaging in a study involving mood and activity monitoring with a range of portable and wearable technologies. METHOD: @entity0 were recruited from a wider sample of 50  individuals with @entity2 taking part in the Automated Monitoring of Symptom Severity (AMoSS) study in Oxford. A sub-set of 21  @entity0 participated in a qualitative interview that followed a semi-structured approach. RESULTS: Monitoring was associated with benefits including @entity1 insight, behavioural change. Concerns were raised about the potential preoccupation with, and @entity3 about, monitoring. @entity0 emphasized the need for personalization, flexibility, and the importance of context, when monitoring mood. CONCLUSIONS: Mobile and electronic health approaches have potential to lend new insights into mental health and transform healthcare. Capitalizing on the perceived utility of these approaches from the @entity0 ' perspective, while addressing their concerns, will be essential for the promise of new technologies to be realised.

title: Experiences of remote mood and activity monitoring in XXXX : A qualitative study.

answer: @entity2


abstract: Intracellular @entity1 was determined with the @entity3 technique during electrically induced contractions in the @entity0 rectococcygeus smooth muscle at 22 degreesC. The muscles were electrically activated to give short, reproducible contractions. Intracellular [ @entity1 ] increased during activation; the increase in [ @entity1 ] preceded force development by approximately 2 s. After cessation of stimulation @entity1 fell, preceding the fall in force by approximately 4 s. The fluorescence properties of @entity3 were determined with time-resolved spectroscopy using synchrotron light at the MAX-storage ring, Lund, Sweden. The fluorescence decay of free @entity3 was best described by two exponential decays (time constants approximately 0.5 and 1.5 ns) at low @entity1 (pCa 9). At high @entity1 (pCa 4.5), fluorescence decay became slower and could be fitted by one exponential decay (1.9 ns). Time-resolved anisotropy of free @entity3 was characteristic of free rotational motion (correlation time 0.3 ns). Motion of @entity3 could be markedly inhibited by high concentrations of @entity4 kinase. Time-resolved spectroscopy measurements of muscle fibers loaded with @entity3 showed that the fluorescence lifetime of the probe was longer, suggesting an influence of the chemical environment. Anisotropy measurements revealed, however, that the probe was mobile in the cells. The @entity1 -dependence of contraction and relaxation was studied using a photolabile @entity2 chelator, @entity5 , which could be loaded into the muscle cells in a similar manner as @entity3 . Photolysis of @entity5 leads to an increase in its @entity1 -affinity and a fall in free @entity1 . When muscles that had been loaded with @entity5 were illuminated with UV light flashes during the rising phase of contraction, the rate of contraction became slower, suggesting a close relation between intracellular @entity1 and the cross-bridge interaction. In contrast, photolysis during relaxation did not influence the rate of force decay, suggesting that relaxation of these contractions is not determined by the rate of @entity1 removal or due to an increased @entity1 sensitivity, but instead is limited by other processes such as deactivation by dephosphorylation or detachment of tension-bearing cross-bridges, possibly regulated by thin filament systems.

title: @entity2 transients and the effect of a photolytically released @entity2 chelator during electrically induced contractions in XXXX rectococcygeus smooth muscle.

answer: @entity0


abstract: BACKGROUND: @entity5 arise from aberrant @entity4 responses to allergens. The processes involved in the genesis of @entity3 sensitization remain elusive. Some allergens such as derived from house dust mites have proteolytic activity which can induce oxidative stress in vivo. A reduced capacity of the host to control oxidative stress might prime for @entity3 sensitization. METHODS: Two different strains of @entity1 were compared for their antioxidant and immune response to HDM. Protease activity of the HDM extract was reduced to investigate its role in oxidative stress induction in the airways and whether this induction could determine @entity3 sensitization and @entity2 . The role of oxidative stress in @entity3 sensitization was also investigated in @entity0 . An occupational cohort of animal workers was followed for the development of sensitization to rodent urinary proteins. Levels of oxidative stress in serum and antioxidant responses by PBMCs were determined. RESULTS: Susceptibility to @entity3 sensitization to mite allergens in @entity1 was highly dependent on host genetic background and was associated with oxidative stress in the lungs before allergen exposure and poor antioxidant response after allergen exposure. Reduction in mite protease activity limited its capacity to induce oxidative stress and @entity2 in @entity1 . We showed that also in @entity0 subjects, oxidative stress before allergen exposure and poor antioxidant responses were associated with predisposition to occupational @entity5 . CONCLUSION: Our study indicates that oxidative stress condition before allergen exposure due to an inadequate antioxidant response may prime for @entity3 @entity4 responses.

title: Allergic sensitization is associated with inadequate antioxidant responses in @entity1 and XXXX .

answer: @entity0


abstract: BACKGROUND: @entity0 with @entity1 ( @entity1 ) and @entity3 are at increased risk of @entity4 ( @entity4 ). Studies have shown differential statin efficacy on low-density lipid @entity2 ( @entity10 ) by @entity4 risk strata. OBJECTIVE: The aim of this study was to evaluate the consistency of effect with @entity8 / @entity7 (E/S) combination therapy, @entity6 , or @entity9 in @entity0 with @entity1 , @entity3 , or neither condition (No @entity1 / @entity3 ), stratified by the National @entity2 Education Panel Adult Treatment Panel III (NCEP ATP III) @entity4 risk group. METHODS: Post hoc analyses of 2 multicenter, double-blind, randomized, 6-week studies comparing E/S 10/10, 10/20, 10/40, or 10/80 mg with either @entity6 10, 20, 40, or 80 mg, or @entity9 10, 20, or 40 mg. Treatments were compared by pooling across all doses for @entity10 reduction and NCEP @entity10 goal attainment in @entity0 with @entity1 , @entity3 without @entity1 , or No @entity1 / @entity3 across NCEP @entity4 risk strata. RESULTS: NCEP @entity10 goal attainment was lowest in the high-risk group with @entity5 (12-64%) and greatest in the moderate and low-risk groups (84-100%). In contrast, @entity10 reduction was generally similar irrespective of disease or risk subgroup. All treatments were generally well tolerated, with overall similar safety regardless of disease and risk level. CONCLUSIONS: In these studies, @entity4 risk strata were inversely related to the likelihood of attaining NCEP @entity10 goals, but did not appear to affect the percentage @entity10 change from baseline. This demonstrates the need for especially aggressive @entity2 lowering necessary to reach the lower @entity10 goal for high-risk @entity0 .

title: Low-density lipoprotein @entity2 reduction and goal achievement with @entity8 / @entity7 versus @entity6 or @entity9 in @entity0 with XXXX , @entity3 , or neither disease, stratified by National @entity2 Education Program risk category.

answer: @entity1


abstract: The incidence of the EGJA is rapidly increasing. The clinicopathological features have not yet been elucidated. The aim of this study was to analyze the differences in clinicopathological features and prognosis between @entity0 with esophagogastric junctional @entity4 (EGJA) and distal @entity3 (DGA).In this retrospective study, 1230 @entity0 who underwent gastrectomy between January 2006 and December 2010 in West China Hospital were enrolled. @entity0 were divided into 2 groups based on @entity1 location. Clinicopathological characteristics, @entity2 , and survival outcomes were compared. Univariate and multivariate analysis were also used to evaluate the prognostic factors of DGA and EGJA. @entity0 with @entity3 were divided into 2 study groups according to @entity1 location: 321 EGJA (26.1%) and 909 DGA (73.9%). Tumors with larger diameter, more advanced pT and pN stage were more common in EGJA. Significant differences were revealed in 3-year overall survival rate (3-YS) between 2 groups: EGJA (57.5%) and DGA (65.5%) (P=0.001), and further analysis indicate that there was also significant difference on 3-YS between EGJA (76.9%) and DGA (84.2%) (P=0.012) in stage II. From our multivariate analysis, we found that there were different independent prognostic indicators for DGA and EGJA.The clinicopathological features of EGJA were strikingly different from DGA and @entity0 with EGJA showed a worse prognosis when compared with DGA. The pT stage, pN stage, pM stage, @entity1 size, age, and radical degree were determined to be independent factors of prognosis for DGA, while only combined organ resection, pN stage, and pM stage were independent prognostic factors for EGJA.

title: Comparison on Clinicopathological Features and Prognosis Between Esophagogastric Junctional @entity4 (Siewert II/III Types) and Distal XXXX : Retrospective Cohort Study, a Single Institution, High Volume Experience in China.

answer: @entity3


abstract: Introduction. @entity6 ( @entity6 ) is a rare @entity1 that primarily involves progressive @entity5 of the legs (hamstrings, quadriceps, and @entity2 ). Methods. A 27-year-old gentleman was a fast runner and able to play soccer until age 9 when he developed slowly progressive @entity4 . He was wheelchair-bound by age 25. He was evaluated by laboratory testing, imaging, electrodiagnostics, and molecular genetics. Results. Electrodiagnostic testing revealed an @entity7 . Genetic testing for @entity6 in 2003 was negative; repeat testing in 2013 revealed a mutation in @entity8 ( @entity10 ; @entity9 ). Conclusions. A recent advance in neurogenetics has allowed for more genes and mutations to be identified; over 76 different genetic loci for @entity6 and 59 gene products are currently known. Even though our @entity0 had a sensorimotor @entity3 on electrodiagnostic testing and a 2003 @entity6 genetic panel that was negative, a repeat @entity6 genetic panel was performed in 2013 due to the advancement in neurogenetics. This revealed a mutation in @entity8 .

title: Progressive Lower Extremity Weakness and @entity7 from a Mutation in @entity8 ( XXXX ; @entity9 ).

answer: @entity10


abstract: BACKGROUND: @entity3 ( @entity3 ) is a rare but lethal malignancy with few reliable prognostic markers. FDG-PET metabolic parameters have been shown to predict survival in several @entity1 . The objective was to determine if metabolic @entity1 volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) could serve as prognostic markers in @entity0 with @entity3 . METHODS: A total of 30 @entity0 with @entity3 prospectively underwent 18F-FDG PET/CT prior to treatment. Whole body MTV, TLG, and SUVmax were measured by a semiautomatic method. A median cutoff was used to determine an association with @entity2 ( @entity2 ) from the time of 18F-FDG PET/CT by the Kaplan-Meier method. RESULTS: @entity0 with high whole body MTV (>87.0 mL),TLG (>229.4 SUVlbm*mL), or SUVmax (>8.9 SUV) had a worse @entity2 compared with those with low whole body MTV (median @entity2 , 24 vs 45.1 months, p < .01), TLG (median @entity2 , 24 vs 40.3 months, p < .005), or SUVmax (median @entity2 , 23.7 vs 35.5 months, p < .02). In @entity0 who had operable disease (n = 23), high whole body MTV (>87.0 mL) and TLG (>229.4 SUVlbm*mL) had a worse @entity2 compared with those with low whole body MTV (median @entity2 , 25.1 vs 45.1 months, p < .05) and TLG (median @entity2 , 25.1 vs 40.3 months, p < .05), but a high SUVmax (>8.9 SUV) was not associated with worse @entity2 (p = .11). CONCLUSIONS: @entity0 with @entity3 and a high whole body MTV, TLG, and SUVmax have a worse prognosis and @entity2 . Measurement of whole body MTV and TLG may be helpful for guiding therapy for @entity0 with @entity3 .

title: Whole Body Metabolic Tumor Volume and Total Lesion Glycolysis Predict Survival in @entity0 with XXXX .

answer: @entity3


abstract: AIMS: @entity6 are @entity5 associated with both skeletal @entity1 and progressive @entity2 in males. Female @entity6 / @entity6 carriers (DMDc/BMDc) are mostly free of skeletal muscle symptoms, but they are also prone to @entity2 . The aim of the current study was to characterize the frequency, pattern, and extent of @entity2 in female @entity6 / @entity6 carriers (DMDc/BMDc) in comparison to their first-degree male @entity4 relatives. METHODS AND RESULTS: Thirty-six (age 44    14 years) female @entity4 carriers (20 DMDc and 16 BMDc) constituted the ' @entity4 carrier group' and were prospectively enrolled. All @entity4 carriers underwent a complete CMR study comprising cine- and late @entity7 enhancement (LGE) imaging. In 22 of these @entity0 ('female @entity4 carrier comparison group', 7 @entity6 and 15 @entity6 ), at least one first-degree male relative with a previously established diagnosis of @entity4 underwent the same CMR protocol and was assigned to the 'male @entity4 comparison group' (n = 24, 6 @entity6 and 18 @entity6 ). In the total @entity4 carrier group, 17 (47%) @entity4 carriers had at least one pathological CMR finding [5 (14%) with a reduced left ventricular ejection fraction (LV-EF) and 16 (44%) with the presence of LGE]. All LGE-positive @entity0 (n = 16) showed non-ischaemic LGE with subepicardial involvement of the LV lateral free wall being the most frequent pattern (13/16, 81%). Compared with BMDc, DMDc demonstrated more frequently a pathological CMR result (65 vs. 19%; P = 0.008)-in spite of being significantly younger (40    11 vs. 50    16 years, P = 0.038). In the male @entity4 comparison group, the same LGE pattern as in female carriers was seen, but with a significantly higher prevalence of @entity3 compared with their female carrier relatives constituting the female @entity4 comparison group (75 vs. 27%; P = 0.003). CONCLUSION: Cardiac involvement is a frequent finding in female carriers of @entity6 , but less frequently observed in carriers of @entity6 . Those DMDc and BMDc with cardiac involvement demonstrate the same @entity2 pattern as their male counterparts with overt disease.

title: Cardiac involvement in female XXXX carriers in comparison to their first-degree male relatives: a comparative cardiovascular magnetic resonance study.

answer: @entity6


abstract: OBJECTIVES: We compared a strategy of tenecteplase (TNK)-facilitated angioplasty with one of TNK alone in @entity0 presenting with high-risk @entity5 ( @entity5 ). BACKGROUND: Previous trials show that thrombolysis followed by immediate angioplasty for the treatment of @entity5 does not improve @entity1 outcomes compared with thrombolysis alone and is associated with excessive @entity4 complications. Since the publication of these trials, however, significant pharmacological and technological advances have occurred. METHODS: We randomized 170 @entity0 with high-risk @entity5 to treatment with TNK alone (84 @entity0 ) or TNK-facilitated angioplasty (86 @entity0 ). The primary end point was a composite of @entity3 , reinfarction, recurrent unstable @entity1 , or @entity2 at six months. RESULTS: At six months, the incidence of the primary end point was 24.4% in the TNK-alone group versus 11.6% in the TNK-facilitated angioplasty group (p = 0.04). This difference was driven by a reduction in the rate of recurrent unstable @entity1 (20.7% vs. 8.1%, p = 0.03). There was a trend toward a lower reinfarction rate with TNK-facilitated angioplasty (14.6% vs. 5.8%, p = 0.07). No significant differences were observed in the rates of @entity3 or @entity2 . Major @entity4 was observed in 7.1% of the TNK-alone group and in 8.1% of the TNK-facilitated angioplasty group (p = 1.00). CONCLUSIONS: In @entity0 presenting with high-risk @entity5 , TNK plus immediate angioplasty reduced the risk of recurrent @entity1 events compared with TNK alone and was not associated with an increase in major @entity4 complications.

title: Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute XXXX (CAPITAL AMI study).

answer: @entity5


abstract: INTRODUCTION: Susceptibility to @entity3 ( @entity3 ) is known to be affected by gender and ethnic origin, but whether gender and ethnicity are interacting is unknown. METHODS: We investigated @entity3 development in healthy Caucasian subjects (n = 227), and in subjects of Chinese origin (n = 82). All subjects were exposed to @entity0 -inducing @entity1 in a rotation chair, and rotated around the yaw axis for 5 x 1 min, while they were instructed to move their heads. Prior to rotation, subjects had to fill out a motion- @entity2 susceptibility questionnaire (MSSQ). Total @entity1 ( @entity1 ) was noted. Symptom ratings (SR) were performed at the beginning, and immediately after the end of each rotation, and 15 and 30 min later. RESULTS: The average @entity1 was significantly higher in Caucasian (163 +/- 6 s) than in Chinese subjects (111 +/- 7 s) (F = 24.84, p < 0.0001). The adult MSSQ score was significantly lower in Caucasians (17.8 +/- 1.1) than in Chinese volunteers (24.2 +/- 2.1) (F = 6.05, p = 0.014). Maximal SR post rotation was similar in Chinese and Caucasian subjects. @entity1 was highly predictable from the MSSQ scores, but separate for both genders. CONCLUSION: Susceptibility to @entity3 is affected by both ethnic origin and by gender in a rather complex fashion. The most reliable prediction of @entity1 can be based on the individual's history as assessed by the MSSQ.

title: Effects of ethnicity and gender on XXXX susceptibility.

answer: @entity3