abstract: BACKGROUND: The decision to take @entity1 ( @entity1 ) is a choice many @entity0 encounter when entering menopause. The purpose of this study was to examine the choice to take @entity1 while participating in a lifestyle intervention to reduce cardiovascular risk through the menopause. METHODS: The @entity0 's Healthy Lifestyle Project is a randomized clinical trial designed to examine whether a behavioral lifestyle intervention can decrease the expected rise in cardiovascular risk through the menopause. @entity0 (N = 535) completed questionnaires and were interviewed regarding menopausal symptoms, menopausal status, hot flashes, and @entity1 use at baseline and 54 months. RESULTS: The intervention was successful in preventing risk elevation through the 54-month visit. At the final visit, there was no difference between the intervention and control groups in the percentage who had become postmenopausal (32.9% vs 35.0%, respectively), there was no difference between control and intervention with @entity1 use, with 31.2% reporting use of @entity1 , and there was no difference between groups with menopausal symptoms. The @entity0 started @entity1 an average of 6 months after they missed a period. Baseline risk factors did not predict @entity1 use at the 54-month visit. CONCLUSIONS: A sizable number of @entity0 reported @entity1 use. The decision to use @entity1 was not influenced by the lifestyle intervention or their baseline cardiovascular risk, and these @entity0 started @entity1 very early in the peri- to postmenopause. Further, weight loss in the perimenopause did not affect menopausal symptoms.

title: Hormone replacement therapy use and menopausal symptoms among XXXX participating in a behavioral lifestyle intervention.

answer: @entity0


abstract: BACKGROUND: @entity5 tends to be complicated with spine and ribcage deformities. In addition to the coronal curvature, among the features of @entity6 , @entity3 , @entity2 , cardiac compression and an aortic left shift are also observed. Aorta is known to shift in a leftward direction, especially at the mid-thoracic level. The cause of aortic left shift in @entity6 is not known. To clarify the features of a @entity1 , especially the relationship of the aortic left shift and the flat @entity3 , we investigated the CT scan images of @entity6 @entity0 . METHODS: For the measurement of @entity6 @entity0 , the pre-operative CT scans of 22 @entity0 with @entity4 were recruited. For controls, 25 age-matched non- @entity6 @entity0 were recruited. The aortic location, the @entity2 angle and chest depth were measured by CT scan. The chest depth was defined as the smallest inner chest cavity depth between the anterior vertebral body and the anterior inner chest wall. RESULTS: @entity3 in @entity6 @entity0 was found to be significantly narrower than the control group at every thoracic level, from T6 to T11. The aortic left shift was significantly larger in @entity6 @entity0 at all measured levels. The chest depth correlated with an aortic leftward shift (r = 0.49). The aortic location was found to be correlated with the @entity2 angle (r = -0.52), and the @entity2 angle correlated with the thoracic side curvature (r = 0.61) CONCLUSIONS: In @entity6 , an aortic left shift correlated with both @entity3 and the @entity2 .

title: Aortic location and flat XXXX : a prospective study.

answer: @entity3


abstract: OBJECTIVE: Persistent hoarseness due to recurrent @entity5 (RLNP) reduces the quality of life unless it is adequately treated. This study examined the indications for phonosurgical intervention in @entity0 with RLNP. MATERIALS AND METHODS: The medical records of the Ehime University Hospital, Ehime, Japan, from October 1976 until December 1997 were reviewed retrospectively to identify @entity0 with RLNP. The data collected included age, gender, paralyzed side, and cause of @entity4 . RESULTS: Four hundred and sixty-six @entity0 with RLNP were identified: 262 males and 204 females. Unilateral RLNP was present in 422 @entity0 , while 44 presented with bilateral RLNP. The incidence was relatively high in the 7th and 8th decades, and was twice as high in male @entity0 as in female @entity0 . The 466 @entity0 were divided into 2 groups: Group 1 included 225 @entity0 seen before January 1987, and Group 2 included 241 @entity0 seen after this date. The number of @entity0 with postoperative RLNP was significantly higher in Group 2 (124 of 239 @entity0 ) than in Group 1 (65 of 227 @entity0 ) (P<0.05). Surgery for @entity1 , @entity3 , and skull base and @entity2 contributed to this increased incidence of postoperative RLNP. CONCLUSIONS: @entity0 with persistent unilateral RLNP require appropriate treatment for hoarseness, regardless of its cause. Since the incidence of RLNP related to surgery was significantly increased in Group 2, phonosurgery has become more important for improving the quality of life of these @entity0 .

title: Causes of recurrent XXXX .

answer: @entity5


abstract: We carried out a retrospective analysis of 283 @entity0 diagnosed with @entity9 in our hospital, which serves almost 5.5 million inhabitants in Southeastern Anatolia in @entity3 . Our study focuses on the frequency of complications in cases with @entity9 across different age groups. @entity0 were classified into three groups according to age: less than 15 years old (group A), 15-45 years old (group B) and over 45 years old (group C). Of 283 @entity0 , 138 (49%) were female and 145 (51%) male. Fifty-three (19%) were younger than 15 years old (group A), 178 (63%) were 15-45 (group B), and 52 (18%) were over 45 (group C). When the distribution of all cases was examined according to months of the year, an increase was seen in June. @entity5 were the most frequent, found in 195 (69%) cases, followed by cutaneous (17%), genitourinary (8%), nervous (7%), respiratory (5%) and hematological (4%) complications. Treatment failed in 15 @entity0 (5%), owing to true relapse in ten and to non-compliance and @entity2 in the other five. Two hundred seventy-two @entity0 received medical treatment alone and 11 required medical and surgical treatment as well (9 @entity7 and 2 @entity8 ). Complications in @entity9 were frequent because 25% of all @entity0 with @entity9 had more than one complication, more so in group C (38%) than in group A (28%) or B (20%). @entity6 in childhood; osteoarticular and @entity4 in adults; and genitourinary, @entity1 in middle aged were more prominent. In conclusion, the frequency of brucella complications was variable in different age groups in Southeastern Anatolia of @entity3 . Since @entity9 is a preventable disease, knowledge and early diagnosis of the complications are especially important. Therefore, population education and medical precautions are necessary to prevent the harmful effects of brucella and its complications. In addition, primary health care physicians should be alerted regarding the clinical and laboratory findings of brucella complications.

title: Complications of @entity9 in different age groups: a study of 283 cases in southeastern Anatolia of XXXX .

answer: @entity3


abstract: 1. Concentrations of @entity3 and @entity6 were studied in islets of Langerhans isolated from @entity0 pancreas and incubated in the presence of various agents that induce insulin release. 2. In response to rising concentrations of extracellular @entity1 (2-10mm) there is a linear increase in the intracellular concentration of @entity3 , though this is not the case for @entity6 , the intracellular concentration of which only increases when the external @entity1 concentration exceeds 5mm. 3. @entity5 , @entity4 and @entity2 , all of which promote insulin secretion from isolated islets, increase the intracellular concentrations of @entity3 and @entity6 . The results obtained in the presence of @entity4 and @entity2 are compatible with an inhibitory effect of @entity2 on islet-cell phosphofructokinase. 4. Theophylline and glucagon when incubated with islets in vitro promote insulin release and cause a rise in @entity6 concentration and not in that of @entity3 . 5. It is suggested that the further metabolism of @entity3 through a pathway other than glycolysis is essential for insulin release. One such pathway involves its oxidation to @entity6 , which seems to be a necessary accompaniment of insulin secretion due to @entity1 . The possibility that agents other than @entity1 promote insulin release by enhancing the oxidation of @entity3 through this pathway is discussed.

title: Islet-cell metabolism during insulin release. Effects of @entity1 , @entity2 , @entity4 , XXXX , glucagon and theophylline.

answer: @entity5


abstract: OBJECTIVES: Digital @entity3 (DUs) are often a primary end point in @entity2 ( @entity2 ) clinical trials, although the reliability of rheumatologists grading DUs is poor to moderate at best. DU assessment in recent trials has been based upon visual inspection alone, which potentially misses 'real-world' clinical contextual information. Our aim was to investigate whether this clinical information improves the reliability of rheumatologists grading DUs. A secondary aim was to assess agreement between @entity0 and rheumatologists. METHOD: Eighty images of a range of digital lesions were collected from @entity0 with @entity2 with the clinical context: @entity1 (severity and temporal relationship), lesion duration and discharge ( @entity0 reported and clinician observed). Raters received all images either with or without the clinical context, and graded these images (using a custom-built interface) on an ordinal scale of severity: 'no @entity3 ', 'inactive @entity3 ' or 'active @entity3 '. @entity0 also graded their lesion/s on the same scale. RESULTS: Fifty-one rheumatologists from 15 countries completed the study (26 without and 25 with context): 4590 (including 510 repeated) image gradings were obtained. Context did not significantly increase (without and with context) either intra- (0.64,0.71) or inter-rater (0.32,0.36) reliability. @entity1 (VAS and temporal relationship) and discharge ( @entity0 reported and clinician observed) were associated with increased lesion severity, and duration with reduced severity. Agreement between individual @entity0 and rheumatologists was poor without and with context (0.19,0.28). CONCLUSION: The overall intra and inter-rater reliability of DU grading did not significantly improve with the clinical context. Agreement between @entity0 and rheumatologists was poor. This article is protected by copyright. All rights reserved.

title: Does the clinical context improve the reliability of rheumatologists grading digital @entity3 in XXXX ?

answer: @entity2


abstract: PURPOSE: This study reviewed the long-term outcome of @entity0 who underwent open repair of infrarenal @entity4 ( @entity4 ). METHODS: A retrospective study of 208 @entity0 (188 @entity0 and 20 @entity0 ) with a mean age of 65.6 years who survived elective or emergency open repair of an infrarenal AAA was conducted at a university referral hospital. Main outcome measures included late graft-related complications, survival free from any reintervention, survival free from any vascular reintervention, and overall survival rates. RESULTS: Late graft-related complications occurred in 32 @entity0 (15.4%). A proximal para-anastomotic @entity6 developed in six @entity0 (2.9%), and a distal @entity6 developed in 18 @entity0 (8.7%); in seven of these cases (3.4%), it was bilateral or recurrent. A graft limb occlusion occurred in 11 @entity0 (5.3%). These complications required 37 surgical or other invasive procedures in 27 @entity0 (13.0%). Thirty-one vascular and/or endovascular reoperations were performed. The 5-year, 10-year, and 15-year survival free from any reintervention rates were 91.5%, 86.2%, and 72.0%, respectively. At the same intervals, the survival free from any vascular reintervention rates were 93.8%, 88.5%, and 73.9%, respectively, and the overall survival rates were 66.8%, 39.4%, and 18.0%, respectively. Complications associated with a ruptured femoral @entity6 , a ruptured aortic @entity6 , an @entity3 , and the elective repair of a femoral @entity6 were the graft-related causes of @entity2 , which occurred in four @entity0 (1.9%). Age (P <.0001) and @entity5 (P =.002) were shown by means of multivariate analysis to be predictive of poor survival outcome, and @entity5 (P =.02) and lower limb @entity1 (P =.04) were shown to be associated with an increased need for vascular reinterventions to treat graft-related complications. CONCLUSION: Open repair of infrarenal @entity4 can achieve satisfactory 15-year follow-up rates of survival free from reintervention for any graft-related complications, suggesting that surgery should still be considered the procedure of choice for infrarenal @entity4 , at least in @entity0 who are fit for surgery.

title: Durability of open repair of XXXX : a 15-year follow-up study.

answer: @entity4


abstract: UNASSIGNED: Extrarenal adverse effects (AEs) associated with @entity12 (CNI) and @entity9 ( @entity10 ) occur frequently but are unpredictable posttransplant complications. AEs may result from intracellular CNI accumulation and low activity of P-glycoprotein, encoded by the @entity6 gene. Since @entity6 single nucleotide polymorphisms (SNPs) and sex influence P-glycoprotein, we investigated haplotypes and extrarenal AEs.A prospective, cross-sectional study evaluated 149 @entity0 receiving @entity5 and enteric coated mycophenolate @entity7 or @entity2 and @entity4 . Immunosuppressive AE assessment determined individual and composite gastrointestinal, neurologic, aesthetic, and cumulative AEs. Lipids were quantitated after 12-hour fast. @entity6 SNPs: @entity11 ( @entity13 ), @entity17 ( @entity14 ), and @entity15 ( @entity16 ) were determined with haplotype associations computed using the THESIAS program, and evaluated by immunosuppression, sex and race using multivariate general linear models.Tacrolimus @entity0 exhibited more frequent and higher gastrointestinal AE scores compared with @entity2 with association to CTT (P=0.018) and sex (P=0.01). Aesthetic AE score was 3 times greater for @entity2 with TTC haplotype (P=0.005). Females had higher gastrointestinal (P=0.022), aesthetic (P<0.001), neurologic (P=0.022), and cumulative AE ratios (P<0.001). Total @entity1 (TCHOL), low-density lipoproteins (LDL), and @entity8 were higher with @entity2 . The TTC haplotype had higher TCHOL (P<0.001) and LDL (P=0.005). Higher @entity3 (P=0.034) and lower high-density lipoproteins (P=0.057) were associated with TTT with sex-adjusted analysis. @entity6 haplotypes and sex were associated with extrarenal AEs. Using haplotypes, certain female @entity0 manifested more AEs regardless of CNI. Haplotype testing may identify @entity0 with greater susceptibility to AEs and facilitate CNI individualization.

title: Association of Extrarenal Adverse Effects of Posttransplant Immunosuppression With Sex and XXXX Haplotypes.

answer: @entity6


abstract: UNASSIGNED: Context: C-peptide positive adults with @entity2 ( @entity2 ) have higher circulating total and free @entity1 and lower @entity6 ( @entity6 ) than C-peptide negative @entity0 . Whether this is also the case in @entity0 remains unknown. Objective: To examine the IGF-system in @entity0 /adolescents with and without @entity5 ( @entity5 ). Design and @entity0 : Cross-sectional study containing 136 pre-pubertal (hereof 15 @entity5 -positive) and 206 pubertal (hereof 42 @entity5 -positive) @entity0 /adolescents with @entity2 for 3-6 years as well as 40 pre-pubertal and 30 pubertal healthy controls. @entity5 was evaluated by meal-stimulated C-peptide. Main Outcome Measures: Fasting serum levels of bioactive IGF (i.e. the ability of serum to activate the @entity3 in vitro), total @entity1 , total @entity4 , and @entity7 . Results: Irrespective of pubertal status, @entity0 with @entity2 showed lower bioactive IGF and total @entity1 , but higher @entity6 as compared to controls (P<0.05). When stratified according to @entity5 -status, a positive @entity5 was associated with normalization of all IGF-related peptides but @entity6 in pre-pubertal @entity0 , (P <0.05), whereas none of the IGF-components were normalized in pre-pubertal, @entity5 -negative @entity0 . In pubertal @entity0 , total @entity1 and bioactive IGF remained subnormal and @entity6 supranormal, irrespective of @entity5 status (P<0.05). Conclusion: Independent of pubertal status, @entity2 was associated with an abnormal IGF-system. However, a positive @entity5 -status appeared important, but only in pre-pubertal @entity0 , in whom all IGF-components but @entity6 were normalized. We speculate that the pubertal GH-surge induces insulin-resistance, which overrides the stimulatory effect that an @entity5 may exert on the liver-derived IGF-system.

title: Residual b-cell function and the insulin-like growth factor system in Danish @entity0 and adolescents with XXXX .

answer: @entity2


abstract: A recessive single gene mutant, 7B-1, in @entity1 was originally selected for its photoperiod-dependent male sterility. The 7B-1 mutant also has some pleiotropic effects including reduced light-induced inhibition, i.e. de-etiolation, of the hypocotyl in long days (LD), increased seed size and weight, and reduced transpiration rate. These traits led us to investigate the sensitivity of 7B-1 to exogenous hormones and the interaction of these responses with daylength. In LD, but not in short days (SD), 7B-1 was more sensitive than wild-type (WT) to exogenous @entity2 ( @entity3 ) for inhibition of seed germination, root elongation and transpiration rate. 7B-1 mutant also exhibited reduced responses to exogenous @entity4 (GA(3)) for hypocotyl elongation, and to inhibitors of GA biosynthesis for seed germination and root and hypocotyl elongation. 7B-1 hypocotyls contained a higher level of endogenous @entity3 than WT in both photoperiods, although @entity3 levels were higher in LD than in SD. In contrast, growth-active GAs, i.e. GA(1), GA(3) and GA(4), and IAA were low in the mutant hypocotyls. The 7B-1 mutant appears to be an @entity3 -overproducer, and the photoperiod-regulated @entity3 levels may be responsible for the @entity0 of the mutant to exogenous @entity3 .

title: Reduced de-etiolation of hypocotyl growth in a @entity1 mutant is associated with @entity0 to, and high endogenous levels of, XXXX .

answer: @entity2


abstract: BACKGROUND: Functional magnetic resonance imaging (fMRI) in neonates has been introduced as a non-invasive method for studying sensorimotor processing in the developing brain. However, previous neonatal studies have delivered conflicting results regarding localization, lateralization, and directionality of @entity1 ( @entity1 ) responses in sensorimotor cortex (SMC). Amongst the confounding factors in interpreting neonatal fMRI studies include the use of standard adult MR-coils providing insufficient signal to noise, and liberal statistical thresholds, compromising clinical interpretation at the single subject level. @entity0 / METHODS: Here, we employed a custom-designed neonatal MR-coil adapted and optimized to the head size of a newborn in order to improve robustness, reliability and validity of neonatal sensorimotor fMRI. Thirteen preterm @entity0 with a median gestational age of 26 weeks were scanned at term-corrected age using a prototype 8-channel neonatal head coil at 3T (Achieva, Philips, Best, NL). Sensorimotor stimulation was elicited by passive extension/flexion of the elbow at 1 Hz in a block design. Analysis of temporal signal to noise ratio (tSNR) was performed on the whole brain and the SMC, and was compared to data acquired with an 'adult' 8 channel head coil published previously. Task-evoked activation was determined by single-subject SPM8 analyses, thresholded at p < 0.05, whole-brain FWE-corrected. RESULTS: Using a custom-designed neonatal MR-coil, we found significant positive @entity1 responses in contralateral SMC after unilateral passive sensorimotor stimulation in all neonates (analyses restricted to artifact-free data sets = 8/13). Improved imaging characteristics of the neonatal MR-coil were evidenced by additional phantom and in vivo tSNR measurements: phantom studies revealed a 240% global increase in tSNR; in vivo studies revealed a 73% global and a 55% local (SMC) increase in tSNR, as compared to the 'adult' MR-coil. CONCLUSIONS: Our findings strengthen the importance of using optimized coil settings for neonatal fMRI, yielding robust and reproducible SMC activation at the single subject level. We conclude that functional lateralization of SMC activation, as found in @entity0 and adults, is already present in the newborn period.

title: Functional Laterality of Task-Evoked Activation in Sensorimotor Cortex of Preterm XXXX : An Optimized 3 T fMRI Study Employing a Customized Neonatal Head Coil.

answer: @entity0


abstract: UNASSIGNED: Early @entity1 are thought to be the initial findings of fibrogenesis in @entity6 , but little is known about their properties. Type IV collagen comprises six gene products, a1-a6, and although it is known as a major basement membrane component, its abnormal deposition is seen in @entity1 of certain organs. We studied the expression of type I and III collagen and all a chains of type IV collagen in lung specimens from @entity0 with @entity3 ( @entity3 ) or @entity4 ( @entity4 ) via immunohistochemistry. With cultured lung fibroblasts, we analyzed the expression and function of all a chains of type IV collagen via immunohistochemistry, western blotting, real-time quantitative PCR, and a Boyden chamber migration assay after the knockdown of a1 and a2 chains. Although we observed @entity2 in early @entity1 of both @entity3 and @entity4 , we found type IV collagen, especially a1 and a2 chains, in early @entity1 of @entity3 but not @entity4 . Fibroblasts enhanced the expression of a1 and a2 chains of type IV collagen after transforming growth factor-b1 stimulation. Small interfering RNA against a1 and a2 chains increased fibroblast migration, with upregulated phosphorylation of @entity5 ( @entity5 ), and adding medium containing fibroblast-produced a1 and a2 chains reduced the increased levels of fibroblast migration and phosphorylation of @entity5 . Fibroblasts in @entity4 were positive for phosphorylated @entity5 but fibroblasts in @entity3 were not. These results suggest that fibroblasts in @entity3 with type IV collagen deposition, especially a1 and a2 chains, have less ability to migrate from early @entity1 than fibroblasts in @entity4 without type IV collagen deposition. Thus, type IV collagen deposition in early @entity1 of @entity3 may be implicated in refractory pathophysiology including @entity1 fibroblasts via a @entity5 pathway.Laboratory Investigation advance online publication, 25 May 2015; doi:10.1038/labinvest.2015.66.

title: Role of a1 and a2 chains of type IV collagen in early XXXX of @entity6 and migration of lung fibroblasts.

answer: @entity1


abstract: OBJECTIVE: This study aimed to compare the summating potential and action potential ratio (SP:AP) in @entity0 with @entity4 before and after various surgical and medical treatments as an indication of change in endolymphatic hydrops to study the progression of @entity4 . STUDY DESIGN: The study design was a retrospective case review. SETTING: The study was conducted at an otology-neurotology referral center. @entity0 : Eighty-eight ears of 84 @entity0 with @entity4 received medical treatment in 18 ears and surgical treatments including endolymphatic shunt in 12 ears, streptomycin perfusion of the lateral semicircular canal in 9 ears, @entity2 perfusion of the middle ear in 33 ears, and @entity1 perfusion of the middle ear in 16 ears. INTERVENTION: Transtympanic electrocochleography (ECoG) was performed in all @entity0 before treatment and 1-57 months after treatment (mean, 13.5 months) with a 2-year interval in 28 @entity0 . MAIN OUTCOME MEASURE: An enlarged SP:AP ratio (> or = 0.40) was used as the diagnostic criterion for endolymphatic hydrops. RESULTS: Overall, an enlarged SP:AP ratio was found in 75% of ears before treatment and 78% after treatment. The SP:AP ratio, when enlarged, remained enlarged in 91% of ears. A nonenlarged SP:AP ratio before treatment became enlarged after treatment in 41% of ears. In American Academy of Otolaryngology-Head and Neck Surgery stage 1 @entity4 (pure-tone threshold average < or = 25 dB), an enlarged SP:AP was found in 58% of ears before treatment and 79% after. Twenty-five (89%) of 28 @entity0 followed for 2 years were free of @entity3 after treatment, and in 22 @entity0 (79%), the SP:AP remained enlarged. The distribution of an enlarged SP:AP ratio was associated with the duration of disease (chi-square = 33.5552, p < 0.01). CONCLUSIONS: The development of endolymphatic hydrops, as indicated by an enlarged SP:AP, is part of the progression of @entity4 . The longer the duration of the disease, the more likely the SP:AP ratio will be enlarged. These findings indicate that endolymphatic hydrops as detected by ECoG was not reversed in this study by the treatments used. Despite the absence of definitive spells of vertigo in most @entity0 , endolymphatic hydrops as evidenced by an enlarged SP:AP ratio persisted.

title: Summating potential and action potential ratio in XXXX before and after treatment.

answer: @entity4


abstract: To evaluate prospectively the effect on mortality of wine drinking in Eastern France, we conducted an analysis on 34,014 consecutive middle-aged @entity0 coming for a comprehensive health appraisal between 1978 and 1983. We evaluated education, physical activity, smoking, and drinking habits by a questionnaire. Electrocardiogram, blood pressure, serum total @entity3 , and gamma-glutamyltransferase level were routinely measured. Seventy-seven per cent of the subjects drank wine; there was little difference between social classes in this proportion. We evaluated mortality over 10-15 years of follow-up. We estimated the relative risk (RR) of @entity5 by Cox proportional hazard models using nondrinkers as the reference and adjusting for six covariables. For an intake of 22-32 and 33-54 gm of @entity4 per day, the RR of all-cause @entity5 was 0.70 [95% confidence interval (CI) = 0.59-0.82] and 0.76 (95% CI = 0.66-0.87), respectively. The lower mortality resulted from fewer deaths from @entity2 and @entity1 . Above 128 gm per day of @entity4 consumption, the RR was 1.37 (95% CI = 1.16-1.61). A moderate intake of wine (2-5 glasses per day) was associated with a 24-31% reduction in all-cause mortality, a proportion that was similar for smokers, ex-smokers, and nonsmokers.

title: XXXX and mortality in middle-aged @entity0 from eastern France.

answer: @entity4


abstract: PURPOSE: To evaluate the 10-year results of surgery for @entity3 and identify factors associated with excellent outcomes and recurrence.    DESIGN: Retrospective, interventional case series.    METHODS: A retrospective analysis was conducted of 319 @entity0 who underwent surgical correction at a tertiary medical center for @entity3 . The main outcome measures were postoperative surgical outcomes and recurrence rates. Excellent lid height was assessed as a @entity4 ( @entity4 ) greater than 3 mm. Recurrence was defined as a lid height less than 50% of the initial postoperative lid height. RESULTS: The overall surgical success rate was 97.2%. On multivariate analysis, 3 factors were significantly associated with a greater probability of achieving excellent lid height: treatment using levator muscle resection (LMR) (adjusted odds ratio [OR], 1.76; P = .04), better preoperative @entity4 (adjusted OR, 2.21; P < .001), and absence of @entity2 (jaw-winking) syndrome (adjusted OR, 0.12; P = .01). For recurrence, 7 significant risk factors were identified: @entity0 less than 1 year old (adjusted OR, 4.92; P = .02), poorer preoperative @entity4 (adjusted OR, 0.64; P = .04), poorer postoperative @entity4 (adjusted OR, 0.32; P < .001), treatment with frontalis suspension (FS) (adjusted OR, 5.86; P < .001), wound @entity1 (adjusted OR, 9.45; P = .02), postoperative entropion (adjusted OR, 11.25; P = .003), and conjunctival prolapse (adjusted OR, 7.10; P = .03). Kaplan-Meier analysis showed that the 1-, 5-, and 10-year recurrence-free rates were 97.3    1.2%, 80.5    4.4%, and 76.7    5.6%, respectively, for the LMR group and 90.9    3.1%, 42.9    8.1%, and 20.8    10.1%, respectively, for the FS group (P < .001, log-rank test).    CONCLUSIONS: Surgical treatment of @entity3 had high success rate. Identifying the risk factors and taking appropriate measures may result in better surgical outcomes and less recurrence. Our retrospective study showed that the likelihood of achieving excellent outcomes with less recurrent rates was higher with LMR than with FS. However, a prospective randomized study is necessary to clarify their efficacy.

title: Factors Associated with Surgical Outcomes in XXXX : A 10-Year Study of 319 Cases.

answer: @entity3


abstract: OBJECTIVE: @entity3 ( @entity3 ) are common in the female population and, over a lifetime, about half of @entity0 have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent @entity4 : intravesical instillation of hyaluronic acid (HA) plus @entity5 (CS), and antibiotic prophylaxis with @entity2 plus @entity1 . MATERIALS AND METHODS: This was a retrospective review of two different cohorts of @entity0 affected by recurrent @entity4 . Cases (experimental group) were @entity0 who received intravesical instillations of a sterile solution of high concentration of HA  +  CS in 50  mL water with @entity6 every week during the 1(st) month and then once monthly for 4 months. The control group included @entity0 who received traditional therapy for recurrent @entity4 based on daily antibiotic prophylaxis using @entity2 200  mg plus @entity1 40  mg for 6 weeks. RESULTS: Ninety-eight and 76 @entity0 were treated with experimental and control treatments, respectively. At 12 months after treatment, 69 and 109 @entity3 were detected in the experimental and control groups, respectively. The proportion of @entity0 free from @entity3 was significantly higher in the experimental than in the control group (36.7% vs. 21.0%; p  =  0.03). Experimental treatment was well tolerated and none of the @entity0 stopped it. CONCLUSION: The intravesical instillation of HA  +  CS is more effective than long-term antibiotic prophylaxis for preventing recurrent @entity4 .

title: Is intravesical instillation of hyaluronic acid and XXXX useful in preventing recurrent @entity4 ? A multicenter case control analysis.

answer: @entity5


abstract: OBJECTIVE: Allograft rejection is still an important cause of morbidity and mortality after heart transplantation (HTx). Many techniques in cardiac magnetic resonance imaging (CMR) were investigated to diagnose acute cellular rejection (ACR). However, there is not enough information about late @entity2 enhancement (LGE) in the myocardium and ACR. METHODS: We prospectively analyzed our consecutive 41 heart transplant recipients who were admitted for routine endomyocardial biopsies. CMR was performed maximum 6 h before the scheduled endomyocardial biopsy. Correlation between LGE in the myocardium and ACR was investigated. RESULTS: Twenty-seven @entity0 showed no rejection, and nine of them had LGE in the myocardium. Fourteen @entity0 had LGE in the left ventricle (LV), and two @entity0 had LGE also in the right ventricle (RV). There was no correlation between LGE and ACR (p=0.879). There was no difference in the @entity1 ( @entity1 ), right ventricular fractional area change (RVFAC), and cardiac ischemic time between the groups (p=0.825, p=0.370, and p=0.419, respectively). LGE in the myocardium could be due to previous rejection episodes; therefore, all @entity0 were retrospectively searched for previous rejection grades and number of episodes. Thirty-eight of the 41 @entity0 had a history of one ACR episode, but none of them had a statistically significant correlation with LGE (for grade 1R, p=0.964 and grade 3R, p=1) There was also no correlation between number of rejection episodes history and LGE. CONCLUSION: LGE is not suitable to detect ACR in heart transplant @entity0 . LGE and the history of ACR have no correlation.

title: Diagnostic performance of late XXXX enhancement in the assessment of acute cellular rejection after heart transplantation.

answer: @entity2


abstract: BACKGROUND: The authors analyse the prevalence of subthreshold @entity2 in primary care and their association with the @entity0 's health perception, disability in daily activities and @entity5 . METHODS: Five-hundred and fifty-four primary care @entity0 who completed a two-phase study were administered the Composite International Interview for Primary Health Care (CIDI-PHC) and other self-report measures. Unweighted and weighted prevalence estimates were obtained for @entity6 and @entity1 defined by specific operational criteria. The impact of @entity1 on health perception, disability in daily activities and @entity5 was analysed by using multiple regression models. RESULTS: The overall prevalence of @entity1 exceeded that of @entity6 . Subjects with @entity1 reported levels of @entity5 , disability in daily activities and perceived health comparable to those of @entity0 with full-fledged @entity6 . When we analysed the associated health characteristics of individual @entity1 , we found that each @entity1 was characterized by poorer health perception, after adjusting for comorbidity with defined disorders and @entity3 , age and gender. Disability in daily activities was increased in individuals with subthreshold @entity4 and @entity8 . LIMITATIONS: The number of cases with subthreshold @entity7 is very small and does not allow one to draw any definite conclusions on their associated characteristics. To reduce non-response bias related to sampling design and refusals, adjusted sampling weights were computed. Since the study design in Bologna and Verona was different and Bologna @entity0 scoring <4 on the General Health Questionnaire were not interviewed, individuals with minimal distress come from the Verona sample alone. CONCLUSIONS: Because of the prevalence and associated characteristics of @entity1 , primary care physicians should attach adequate importance to the @entity0 's perceived poor health, distress and inability to fulfil daily tasks. The clinical relevance of @entity1 has also potential implications for ongoing revisions of classification systems.

title: Subthreshold XXXX in primary care: prevalence and associated characteristics.

answer: @entity2


abstract: INTRODUCTION: African Americans have a greater incidence of @entity1 than whites and have been underrepresented in clinical trials. In the PointBreak trial (pemetrexed- @entity5 -bevacizumab and maintenance pemetrexed-bevacizumab [PemCBev] vs. @entity3 - @entity5 -bevacizumab and maintenance bevacizumab [PacCBev]), 10% of the @entity0 were African American. PointBreak had negative findings; PemCBev did not demonstrate superior @entity4 ( @entity4 ). MATERIALS AND METHODS: PointBreak subgroup efficacy and safety data were retrospectively analyzed: African Americans versus whites for PemCBev; PemCBev versus PacCBev in African Americans; and @entity6 versus community settings for African Americans. Hazard ratios (HRs) and P values were derived from a multivariate Cox proportional hazards model after adjusting for covariates. RESULTS: Of 939 intent-to-treat (ITT) @entity0 , 94 were African American and 805 were white. African-American enrollment was uniform across the study sites (median, 1 African American per site). In the PemCBev arm, @entity4 (HR, 1.125; P  = .525), progression-free survival (PFS) (HR, 1.229; P  = .251), response (P  = .607), and @entity2 profiles were similar in African Americans versus whites. For African Americans, @entity4 (HR, 1.375; P  = .209), PFS (HR, 0.902; P  = .670), response (P  = 1.000), and @entity2 profiles were similar in the PemCBev versus PacCBev arm. For African Americans, no significant differences were seen in @entity4 (HR, 0.661; P  = .191) or PFS (HR, 0.969; P  = .915) in @entity6 versus community practice settings. CONCLUSION: In the PemCBev arm, this exploratory analysis showed no significant differences between African Americans and whites for the efficacy outcomes or @entity2 profiles. Consistent with the ITT population negative trial result, for African Americans, the median @entity4 was not superior for either arm. For African Americans, PFS and @entity4 were similar in the  @entity6 and community settings. Additional outcomes data for African Americans should be collected in @entity1 studies.

title: Exploratory Subset Analysis of African Americans From the PointBreak Study: Pemetrexed- @entity5 -Bevacizumab Followed by Maintenance Pemetrexed-Bevacizumab Versus @entity3 - XXXX -Bevacizumab Followed by  Maintenance Bevacizumab in @entity0 With Stage IIIB/IV Nonsquamous Non-Small-Cell @entity1 .

answer: @entity5


abstract: Subcutaneously implanted, in vitro engineered tissue is generally affected by the immune system of the host even in autogenous transplantation. The aim of this study was to investigate immunomodulation of subcutaneously implanted tissue-engineered cartilage transplants by intramuscular @entity3 application. Transplants consisted of auricular @entity0 chondrocytes, @entity4 - @entity5 co-polymer fleeces and species-specific fibrin or agarose. The transplants were subcutaneously implanted in the ridge. Thereafter, animals were separated into two groups, one with and one without @entity3 treatment. The specimens were histologically investigated after 6 and 12 weeks. Fleece fiber degradation was complete after 12 weeks, and all transplants showed areas of @entity2 . The @entity1 -treated group presented pronounced trabecular bone generation without @entity6 . The untreated group showed sporadic islets of @entity2 without coherent bone formation, and adjacent fibrous tissue had infiltrated the transplants. Native controls and corticoid-treated transplants did not exhibit bone generation or signs of @entity6 . This study found that immunomodulation by intramuscular @entity3 application protects tissue-engineered autogenous chondrocyte transplants from @entity6 and induces trabecular bone formation.

title: Immunomodulation of tissue-engineered transplants: in vivo bone generation from XXXX -stimulated chondrocytes.

answer: @entity3


abstract: OBJECTIVES: To describe the course of @entity2 and sciatica and to identify clinically important prognostic factors for these conditions. DESIGN: Systematic review. DATA SOURCES: Searches of Medline, Embase, Cinahl, and Science Citation Index and iterative searches of bibliographies. MAIN OUTCOME MEASURES: @entity1 , disability, and return to work. RESULTS: 15 studies of variable methodological quality were included. Rapid improvements in @entity1 (mean reduction 58% of initial scores), disability (58%), and return to work (82% of those initially off work) occurred in one month. Further improvement was apparent until about three months. Thereafter levels for @entity1 , disability, and return to work remained almost constant. 73% of @entity0 had at least one recurrence within 12 months. CONCLUSIONS: @entity0 with @entity2 and associated disability usually improve rapidly within weeks. None the less, @entity1 and disability are typically ongoing, and recurrences are common.

title: Acute XXXX : systematic review of its prognosis.

answer: @entity2


abstract: BACKGROUND: Ewing's @entity3 , @entity5 , and @entity8 are significantly more responsive to chemotherapy than other @entity3 . Adjuvant chemotherapy is used routinely based on data from randomized trials. Although a percentage of @entity0 with locally advanced or @entity1 remain curable, few data exist regarding the @entity2 's natural history or response and survival in adults. METHODS: This Phase II study evaluated @entity6 , @entity10 , @entity9 , and mesna (MAID) in adults with inoperable or metastatic @entity11 , @entity8 , or @entity5 . RESULTS: Between 1987-1991, 81 @entity0 were entered; 69 @entity0 were eligible. One @entity0 died of @entity4 . Ten @entity0 (14%) responded completely and 34 @entity0 (49%) had a complete or partial response. Response rates were significantly higher for @entity0 with @entity11 and @entity8 than for those with @entity5 (77%, 64%, and 26%, respectively; P < 0.005). Although there were no significant differences in progression free survival by histology, survival for @entity0 with @entity11 was significantly longer than for @entity0 with @entity5 (P = 0.004.) At the time of last follow-up, 7 @entity0 (10%) were alive without progression: 3 with @entity11 , 1 with @entity5 , and 3 with @entity8 . CONCLUSIONS: MAID chemotherapy is an active regimen in adults with advanced or metastatic @entity11 and @entity8 . Although there was no direct comparison with a @entity6 and @entity7 -based regimen, the response rate and survival in @entity0 with @entity5 suggest that @entity6 and @entity7 -based chemotherapy would remain the accepted initial chemotherapy regimen. For @entity0 with @entity8 and @entity11 , 10-20% of @entity0 remained disease free at 5 years.

title: A Southwest Oncology Group and @entity2 and Leukemia Group B phase II study of @entity6 , XXXX , @entity9 , and mesna in adults with advanced @entity5 , @entity11 , and @entity8 .

answer: @entity10


abstract: PURPOSE: The combination of chemotherapy and radiotherapy is emerging as the new standard modality for the treatment of locally advanced @entity2 , due to the inherent functional and cosmetic sequelae associated with its surgical management. Combination chemotherapy with @entity5 and @entity4 (FP) is one of the most active regimens for the @entity2 . Furthermore, both agents are known to act as radiosensitizer. This study was conducted to determine the efficacy, feasibility, and the @entity3 of concurrent FP chemotherapy with radiotherapy. MATERIALS AND METHODS: @entity0 with histologically proven locally advanced @entity2 (T3-4 or node positive) were enrolled in the study. @entity0 received @entity5 , 1,000 mg/m2/day, continuously for 4 days, and @entity4 , 75 mg/m2, on day 1. This regimen was given every four weeks. The radiotherapy (45 Gy) was started on day 1 of the first cycle, and administered in 25 fractions. Following a three-week interval, the radiotherapy was resumed on day 1 of the third cycle of chemotherapy, and administered in 15 fractions (27 Gy). RESULTS: Of the 31 eligible @entity0 included, 28 were able to be evaluated for the @entity1 response. The response rate for the 28 @entity0 was 93% (16 complete responses, 10 partial responses). Disease free survival for the 16 complete responders was 37 months (median, 1 ~41 months), with a median follow-up time of 31 months. The 1-, 2-, and 3-year survival rates were 82%, 69%, and 63%, respectively. Regarding the feasibility of this treatments, only nineteen @entity0 (61%) received the complete courses of scheduled treatments. The median duration of admission for all @entity0 was 39 days. Grade 3 or 4 @entity6 were observed in 25 @entity0 (83%) and appeared as the dose limiting @entity3 of this regimen. CONCLUSION: Although FP chemotherapy with concurrent radiotherapy is toxic, it is an effective and relatively feasible treatment for locally advanced @entity2 . The majority of @entity0 experienced severe @entity6 , which appeared as the dose limiting @entity3 of this regimen.

title: @entity5 and XXXX (FP) with Concurrent Radiotherapy for Locally Advanced @entity2 .

answer: @entity4


abstract: OBJECTIVE: To study the results of petrosal bone imaging and audiometric long-term follow-up of two @entity0 with @entity6 and relate them to the clinical features, including caloric responses. STUDY DESIGN: Longitudinal case study. SETTING: Tertiary referral center. @entity0 : A father and son with the @entity6 . MAIN OUTCOME MEASURES: Both @entity0 underwent imaging studies to detect and evaluate @entity1 . Longitudinal audiometric analysis of the hearing threshold data over the previous 23 years was performed. Caloric tests were performed at various ages. RESULTS: The son had a short, wide internal acoustic canal, a hypoplastic cochlea, a plump vestibule, and a wide vestibular aqueduct on both sides; the semicircular canals and endolymphatic sac were of normal size. He showed @entity4 . Caloric tests disclosed @entity3 on the left side. The father had a plump internal acoustic canal and hypoplastic cochlea on both sides. The left vestibule was hypoplastic, and the @entity7 was marginally enlarged. He showed severe @entity2 , without substantial progression or fluctuation, and caloric areflexia on the left side. CONCLUSION: These findings suggest a correlation between @entity4 with @entity5 and the presence of an @entity8 in the @entity6 . Additional longitudinal case studies are needed to further evaluate such a correlation.

title: Progressive fluctuant @entity2 , @entity8 , and cochlear hypoplasia in XXXX .

answer: @entity6


abstract: UNASSIGNED: Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. @entity0 treated with contemporary antiplatelet agents, peri-procedural @entity4 therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing costs of these devices in most countries there remain very few indications where @entity0 should be denied treatment with standard-of-care DES therapy. The two major causes of stent failure are stent @entity3 (ST) and in-stent @entity1 (ISR). The incidence of both has reduced considerably in recent years. Current clinical registries and randomized trials with broad inclusion criteria show rates of ST at or <1% after 1 year and    0.2-0.4% per year thereafter; rates of clinical ISR are 5% respectively. Angiographic surveillance studies in large cohorts show rates of angiographic ISR of    10% with new-generation DES. The advent of high-resolution intracoronary imaging has shown that in many cases of late stent failure neoatherosclerotic change within the stented segment represents a final common pathway for both @entity3 and restenotic events. In future, a better understanding of the pathogenesis of this process may translate into improved late outcomes. Moreover, the predominance of non-stent-related disease as a cause of subsequent @entity2 during follow-up highlights the importance of lifestyle and pharmacological interventions targeted at modification of the underlying disease process. Finally, although recent developments focus on strategies which circumvent the need for chronically indwelling stents-such as @entity5 or fully bioresorbable stents-more data are needed before the wider use of these therapies can be advocated.

title: Stent XXXX and @entity1 : what have we learned and where are we going? The Andreas Gr  ntzig Lecture ESC 2014.

answer: @entity3


abstract: STUDY OBJECTIVES: The aim of this study was to compare the @entity1 desaturation index (ODI) generated by two different sleep software systems. METHODS: @entity0 undergoing diagnostic polysomnography for suspected @entity2 underwent simultaneous oximetry recording using the ResMedApneaLink Plus device ( @entity3 ) and Compumedics Profusion @entity4 system (Comp). The ODI was calculated by the algorithms in the respective software of each system. To determine if differences were due to algorithm or recording devices, the Comp software was also used to generate ODI values using oximetry data from the @entity3 . RESULTS: In 106 @entity0 , there was good correlation but poor agreement in the ODI generated by the two systems. @entity3 ODI values tended to be higher than Comp ODI values, but with significant variability. For ODI4%, bias was 4.4 events/h (95% limits of agreement -5.8 to 14.6 events/h). There was excellent correlation and agreement when the same oximetry raw data was analyzed by both systems. For ODI4%, bias was 0.03 events/h (95% limits of agreement -2.7 to 2.8 events/h). Similar results were evident when the ODI3% was used. CONCLUSIONS: There is a clinically significant difference in ODI values generated by the two systems, likely due to device signal processing, rather than difference in ODI calculation algorithms.

title: XXXX Desaturation Index Differs Significantly Between Types of Sleep Software.

answer: @entity1


abstract: Food adhesion is an important attribute that could have both positive and negative ramifications depending on the application. Yet, its quantification remains cumbersome and as a consequence adhesion models are scarce. The effect of surface roughness, free energy, and @entity1 treatment on adhesion of rough low linear density @entity0 films was investigated. Adhesion was measured by a 180 degrees peel strength test. The plastic films were roughened (surface roughness ratio, r, ranged from 1.00 to 1.15). Exposing the film to @entity1 treatment (0 to 300 s) modified its surface free energy, gamma(s) (32.4 to 37.9 mJ/m(2), respectively), and its polar component of the surface free energy, gamma(p)(s) (3.0 to 8.3 mJ/m(2), respectively). The films were coated with @entity2 capable of forming @entity3 bonds. Adhesion was found to be a function of the apparent contact angle of water, theta(ap[water]), surface roughness ratio, and surface free energy. The linear relationship between the apparent contact angle of water, theta(ap[water]), and gamma(p)(s) was incorporated in building an empirical model that quantifies peel strength as function of r and gamma(p)(s). The model showed good agreement with experimental data, especially for longer @entity1 exposures and rougher surfaces. The empirical model provides insight into the relationships between surface roughness, surface energy, and adhesion. Quantifying these effects could facilitate reducing biofilm forming on food equipment, antisticking treatments, or easy peel packages, or reducing food residues adhering to the food packages and consequently minimize oxidation, off flavors, and waste.

title: Adhesion modeling on rough low linear density XXXX .

answer: @entity0


abstract: Studies have shown that metallothionein (MT) is overexpressed in some @entity0 @entity2 and that overexpression can predict treatment response to neoadjuvant @entity3 , @entity4 , and @entity6 chemotherapy. In the present study the UROtsa cell line, a model of normal @entity0 urothelium, was used to determine the expression of the @entity0 @entity13 genes and MT protein following exposure to @entity7 or @entity10 at lethal and sublethal levels. Acute exposure was modeled by treating confluent cultures with 100 microM @entity10 or 53.4 microM @entity7 for 4 h followed by a 48-h recovery period. Extended exposure was modeled by treating confluent cells with 1, 4, and 8 microM @entity8 or 1, 5, and 9 microM @entity5 for 16 d, with the highest concentrations producing cell lethality. The expression of MT mRNAs and protein were determined by reverse-transcription polymerase chain reaction (RT-PCR) and immunoblot analysis. Cell viability was determined by the @entity1 assay. It was shown that acute exposure to either @entity8 or @entity5 increased the levels of mRNAs for the @entity11 , @entity12 , and @entity9 genes, whereas extended exposure only increased these mRNAs following exposure to @entity5 . It was shown that both acute and extended exposure to either @entity8 or @entity5 increased the levels of MT protein, reaching a maximal value of 8 ng MT protein/microg total protein for acute exposure to @entity5 . This is in contrast to previous studies using cultured @entity0 proximal tubule cells, where similar extended treatment with @entity5 resulted in over 20-fold higher MT protein levels. These studies demonstrate that @entity0 urothelial cells accumulate only modest amounts of MT protein when exposed to either @entity5 or @entity14 for a 16-d time period.

title: Metallothionein isoform 1 and 2 gene expression in a @entity0 urothelial cell line (UROtsa) exposed to @entity7 and XXXX .

answer: @entity10


abstract: INTRODUCTION: Mesenchymal stem/stromal cells (MSCs) improve the metabolic function of co-cultured hepatocytes. The present study aimed to further enhance the trophic effects of co-culture with hepatocytes using @entity4 preconditioning (HPc) of the MSCs and also to investigate the underlying molecular mechanisms involved. METHODS: @entity0 adipose tissue-derived MSCs were subjected to @entity4 (2 % O2; HPc) or normoxia (20 % O2) for 24 h and then co-cultured with isolated @entity0 hepatocytes. Assays of metabolic function and apoptosis were performed to investigate the hepatotrophic and anti-apoptotic effects of co-culture. Indirect co-cultures and co-culture with MSC-conditioned medium investigated the role of paracrine factors in the hepatotrophic effects of co-culture. Reactive @entity1 species (ROS) activity was antagonised with @entity7 to investigate whether HPc potentiated the effects of MSCs by intracellular ROS-dependent mechanisms. Tumour @entity2 factor ( @entity3 , transforming growth factor (TGF)-b1, and extracellular collagen production was determined and @entity10 and @entity6 / @entity5 signalling pathways analysed to investigate the role of soluble factors, extracellular matrix deposition, and apoptosis-associated gene signalling in the effects of co-culture. RESULTS: HPc potentiated the hepatotrophic and anti-apoptotic effects of co-culture by ROS-dependent mechanisms. There was increased MSC @entity8 production, and enhanced MSC deposition of extracellular collagen, with reduced synthesis of @entity3 , as well as a downregulation of the expression of pro-apoptotic @entity10 , @entity6 , @entity9 and @entity11 genes and upregulated expression of anti-apoptotic @entity5 in hepatocytes. CONCLUSIONS: HPc potentiated the trophic and anti-apoptotic effects of MSCs on hepatocytes via mechanisms including intracellular ROS, autocrine TGF-b, extracellular collagen and caspase and @entity6 / @entity5 signalling pathways.

title: XXXX preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured @entity0 primary hepatocytes.

answer: @entity4


abstract: AIMS: Percutaneous coronary interventions for bifurcation lesions are often complex and associated with an unsatisfactory result. The aim of this first-in- @entity0 , observational study was to investigate the efficacy and safety of a @entity3 -eluting balloon in these lesions. METHODS AND RESULTS: Twenty-eight @entity0 presenting significant coronary bifurcational lesions of the left coronary artery were studied. The main branch (MB) and the side branch (SB) were dilated with a drug-eluting balloon ( @entity5 ; SeQuent Please balloon catheter , 3   g @entity3 /mm2 balloon surface). An open-cell bare-metal stent (BMS; Coroflex) was then deployed in the MB. Only if the SB had a TIMI flow <III and/or a residual stenosis of >=  50%, a BMS was implanted in the SB. The procedure was successful in all @entity0 . At nine months, the late lumen loss (LLL) in the MB was 0.38    0.46 mm and 0.21    0.48 mm in the SB resulting in an @entity4 of 2.2    0.60 mm in the MB and 1.7    0.44 mm in the SB. Three @entity0 had angiographic restenosis and in one a @entity1 revascularisation (TLR) was performed. Two @entity0 experienced a late stent @entity2 at six and eight months. No @entity0 died. CONCLUSIONS: Percutaneous treatment of bifurcation lesions with a drug-eluting balloon resulted in a procedural success of 100%. Follow-up angiography at nine months showed DES-like results in MB and SB. However, when the @entity5 was used in combination with a BMS (MB), the possibility of late stent @entity2 cannot be ruled out.

title: Treatment of bifurcation lesions with a drug-eluting balloon: the PEPCAD V ( XXXX Eluting PTCA Balloon in Coronary Artery Disease) trial.

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) is a rare condition leading to grotesque disfigurement. Complete removal is almost impossible and recurrences inevitable. The objective of this study was to evaluate powered-assisted liposuction (PAL) for the treatment of @entity4 . METHODS: Magnetic resonance imaging (MRI) was performed before and after surgery for quality assessment. To exclude @entity1 incisional biopsies were taken before surgery. Outcome measures included aspiration volumes, duration of surgery, early morbidity, recurrence rates, and overall @entity0 satisfaction. RESULTS: Seven male @entity0 aged between 43 and 70 years were identified. The mean liposuction volume equaled 2948  1566 mL, the mean surgery time 74  28 minutes. One @entity3 was observed, whereas 1 recurrence rate was noticed after a mean follow-up of 14 months. Malignancy was excluded by histology in 5 @entity0 . Preoperative MRI confirmed the diagnosis with no signs for @entity1 and showed an efficient @entity2 . After a mean follow-up of 18 months, a high @entity0 satisfaction was achieved. CONCLUSION: PAL can serve as an efficient method for the treatment of @entity4 . It has a significant effect on tightening of the skin, leading to a high @entity0 satisfaction.

title: Power-assisted liposuction (PAL) of XXXX ( @entity4 )-a longitudinal study.

answer: @entity4


abstract: PURPOSE: The pharmacokinetics of @entity6 , @entity3 ( @entity3 ) and @entity5 were investigated in order to built a population pharmacokinetic model for the anticancer drug UFT, administered with @entity4 and @entity2 . METHODS: A total of 31 @entity1 with metastatic @entity0 were treated with escalating oral doses of UFT (300 to 500 mg per day) plus @entity4 (90 mg per day) in combination with intravenous @entity2 (15 to 25 mg/m(2)). Concentration-time data were obtained on days 1, 8, 15 and 21 of cycle 1. RESULTS: Of the 31 @entity1 treated, 30 were available for the pharmacokinetic analysis. Ftorafur, 5FU and @entity5 appeared rapidly in plasma and showed large interpatient variations. Ftorafur concentrations were higher than those of 5FU and @entity5 . AUC significantly increased between day 1, and days 8, 15 and 21. Ftorafur C(max) and AUC values were proportional to UFT dose, whereas C(max) and AUC values of 5FU and @entity5 were not linearly related to UFT dose. The pharmacokinetics of ftorafur were ascribed to a two-compartment open model in which 5FU was produced from the central compartment. The absorption and exponential distribution rate constants were assumed equal. The effect of @entity5 on 5FU elimination was straightforward, since no reasonable curve-fitting could be obtained for 5FU data when this covariate was not taken into account. The @entity5 concentration inducing a 50% reduction in 5FU elimination was 2.67 micro mol.l(-1). This result confirms the important role played by @entity5 as a competitive inhibitor of 5FU catabolism. CONCLUSION: A pharmacokinetic model for ftorafur and 5FU was developed and should be useful to further study drug interactions and establish dosing guidelines.

title: Modelling of ftorafur and @entity3 pharmacokinetics following oral UFT administration. A population study in 30 @entity1 with XXXX .

answer: @entity0


abstract: Despite the increasing popularity of total lumbar disc replacement (TDR) in predominantly young and active @entity0 , no previous study has addressed possibilities, limitations and potential risks regarding @entity2 performance following TDR. Mechanical concerns remain and the implant's resilience as regards its load-bearing capacity during sporting activities is unknown. Thirty-nine @entity2 @entity0 fulfilled the inclusion criteria for this study. These @entity0 participated in a large variety of different types of sport. Significant and lasting @entity1 was attained following TDR with a mean follow-up of 26.3 months (range 9-50.7 months; FU rate 97.4%). Sporting activity was resumed within the first 3 months (38.5%) to 6 months (30.7%) with peak performance being reached after 5.2 months. Thirty-seven @entity0 (94.9%) achieved resumption of sporting activity. Athletic performance improved significantly in 33 @entity0 (84.6%). Minor subsidence was observed in 13 @entity0 (30%) within the first 3 months with no further implant migration thereafter in 12 @entity0 . Participation in all types of sport recorded in this study was accessible for a high rate of @entity0 up to the level of professional athletes as well as those participating in extreme sports. Preoperative participation in sport proved to be a strong positive predictor for highly satisfactory postoperative outcome following TDR. In a selected group of @entity0 , however, preoperative inability to participate in sporting activities did not impair postoperative physical activity. Due to the young age of the @entity0 and significant load increase exerted during @entity2 activities, persisting concerns regarding the future behaviour of the implant remain and will require longer follow-up, modified investigation techniques and larger @entity0 cohorts.

title: Total lumbar disc replacement in athletes: clinical results, return to sport and XXXX performance.

answer: @entity2


abstract: Recent reports have indicated that endothelin-induced vasoconstriction in isolated @entity4 may be mediated by the production of @entity3 anion. The purpose of this study was to determine the role of @entity3 anion in mediating the chronic renal and @entity2 actions of endothelin. @entity5 (5 pmol/kg per minute) was chronically infused into the jugular vein by use of mini-osmotic pump for 9 days in male @entity1 and in @entity1 treated with the @entity3 anion scavenger @entity7 (30 mg/kg per day). Mean arterial pressure in the @entity5 -treated @entity1 was 141+/-3 mm Hg, compared with 125+/-2 mm Hg in control @entity1 . @entity5 increased renal vascular resistance (15.3+/-2.5 versus 10+/-1.3 mm Hg/mL per minute) and decreased renal plasma flow (6.5+/-0.9 versus 8.7+/-0.7 mL/min) in control @entity1 . @entity5 also significantly increased TBARS in the kidney and urinary @entity6 excretion. The increase in arterial pressure in response to @entity5 was completely abolished by @entity7 (127+/-4 versus 127+/-4 mm Hg). @entity7 also markedly attenuated the renal plasma flow and renal vascular resistance response to @entity5 . @entity7 also significantly decreased the level of @entity6 in the @entity5 -treated @entity1 . @entity7 had no effect on arterial pressure or renal hemodynamics in control @entity1 . These data indicate that formation of reactive @entity0 species may play an important role in mediating @entity2 induced by chronic elevations in endothelin.

title: Role of reactive @entity0 species in endothelin-induced XXXX .

answer: @entity2


abstract: BACKGROUND: @entity5 has been identified as a risk factor for @entity3 ( @entity3 ). South Asians appear to have a high incidence of @entity3 , while East Asians have a very low incidence. HYPOTHESIS: The present study was undertaken because the relative association of plasma @entity4 levels (PH) with @entity3 in South Asians (SA = Indian, Pakistani, @entity6 Lankan) and East Asians (EA = Chinese, Japanese) is not known. METHODS: Fasting PH were drawn on all @entity0 with @entity3 of SA (age 62.4+/-1.1 years, 72 @entity0 , 14 @entity0 ) and EA (age 61.8+/-3.0 years, 13 @entity0 , 4 @entity0 ) descent. These were compared with PH available from Caucasian (CA) @entity0 (age 61.1+/-1.1 years, 89 @entity0 , 17 @entity0 ) with @entity3 . RESULTS: The PH in SA, EA, and CA @entity0 were 11.0+/-0.5, 7.6+/-0.5, and 10.8+/-0.6 micromol/l, respectively (p<0.001 between EA and SA/CA). Percentages of SA, EA, and CA with elevated PH (> 12.0 micromol/l) were 33.7, 5.9, and 28.2%, respectively. There were no significant differences in the lipid subfractions between the SA and EA group. History of smoking was significantly higher in the EA (52.9 vs. 26.2%), while @entity2 and @entity1 had similar prevalences. CONCLUSION: Significant differences in PH of SA versus EA @entity0 with @entity3 exist. The relative contribution of @entity4 in the development of @entity3 appears to be less in EA immigrants. In contrast, the association between @entity3 and PH in SA immigrants appears to be similar to that of Caucasians.

title: Possible ethnic differences in plasma XXXX levels associated with @entity3 between south Asian and east Asian immigrants.

answer: @entity4


abstract: BACKGROUND: To compare the safety and efficacy of @entity6 ophthalmic ointment 0.5% (LE ointment), a new topical ointment formulation, with vehicle for the treatment of @entity1 and @entity2 following @entity3 surgery. METHODS: Two randomized, multicenter, double-masked, parallel-group, vehicle-controlled studies were conducted. @entity0 aged >= 18 years with a combined postoperative anterior chamber cells and flare (ACI) >=  Grade 3 following uncomplicated @entity3 surgery participated in seven study visits. @entity0 self-administered either topical LE ointment or vehicle four times daily for 14 days. Efficacy outcomes included the proportion of @entity0 with complete resolution of ACI and the proportion of @entity0 with no (Grade 0) @entity2 at postoperative day 8. Safety outcomes included the incidence of adverse events, ocular symptoms, changes in intraocular pressure and visual acuity, and biomicroscopy and funduscopy findings. RESULTS: Data from the two studies were combined. The integrated intent-to-treat population consisted of 805 @entity0 (mean [standard deviation] age 69.0 [9.2] years; 58.0% female and 89.7% white). Significantly more LE ointment-treated @entity0 than vehicle-treated @entity0 had complete resolution of ACI (27.7% versus 12.5%) and no @entity2 (75.5% versus 43.1%) at day 8 (P < 0.0001 for both). Fewer LE ointment-treated @entity0 required rescue medication (27.7% versus 63.8%), and fewer had an ocular adverse event (47.2% versus 78.0%, P < 0.0001) while on study treatment. The most common ocular adverse events with LE ointment were @entity1 , photophobia, @entity5 , @entity4 , @entity7 , and @entity8 . Mean intraocular pressure decreased in both treatment groups. Four @entity0 had increased intraocular pressure >= 10 mmHg (three LE ointment and one vehicle) prior to rescue medication. Visual acuity and dilated funduscopy results were similar between the treatment groups, with the exception of visual acuity at visits 5 and 6, which favored LE ointment. CONCLUSION: LE ointment was efficacious and well tolerated in the treatment of @entity1 and @entity2 following @entity3 surgery.

title: Safety and efficacy of @entity6 ophthalmic ointment 0.5% for the treatment of @entity1 and XXXX following @entity3 surgery.

answer: @entity2


abstract: During the recent period, dermoscopy has yielded improvement in the early disclosure of various @entity0 ( @entity0 ) of the skin. Beyond this clinical procedure, @entity0 histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in @entity0 merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of @entity0 types. Furthermore, some @entity0 have been differently named in the literature including atypical @entity0 , metastasizing @entity0 , borderline and intermediate @entity0 , malignant @entity4 , @entity3 or @entity2 . Some acronyms have been further suggested such as MELTUMP (after @entity0 of uncertain malignant potential) and STUMP (after @entity0 of uncertain malignant potential). In this review, such @entity0 at the exclusion of @entity2 ( @entity2 ) variants, are grouped under the tentative @entity1 . Such set of @entity0 frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and @entity2 remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any @entity0 risk if present.

title: Simulants of XXXX .

answer: @entity2


abstract: UNASSIGNED: We aimed to quantify the ACE I/D and @entity2 @entity3 ( @entity4 ) genetic variants in elite rugby athletes (rugby union and league), compare genotype frequencies to controls and between playing positions. The rugby athlete cohort consisted of 507 Caucasian @entity0 , including 431 rugby union athletes that for some analyses were divided into backs and forwards and into specific positional groups: front five, back row, half backs, centers and back three. Controls were 710 Caucasian @entity0 and @entity0 . Real-time PCR of genomic DNA was used to determine genotypes using TaqMan probes and groups were compared using Chi-square and odds ratio (OR) statistics. Correction of p-values for multiple comparisons was according to Benjamini-Hochberg. There was no difference in ACE I/D genotype between groups. @entity2 XX genotype tended to be underrepresented in rugby union backs (15.7%) compared to forwards (24.8%; P=0.06). Interestingly, the 69 back three players (wings and full backs) in rugby union included only six XX genotype individuals (8.7%), with the R allele more common in the back three (68.8%) than controls (58.0%;   (2)=6.672, P=0.04; OR=1.60) and forwards (47.5%;   (2)=11.768, P=0.01; OR=2.00). Association of @entity2 @entity3 with playing position in elite rugby union athletes suggests inherited @entity1 resistance is more prevalent in forwards while inherited sprint ability is more prevalent in backs, especially wings and full backs. These results also demonstrate the advantage of focusing genetic studies on a large cohort within a single sport, especially when intra-sport positional differences exist, instead of combining several sports with varied demands and athlete characteristics.

title: Association of XXXX @entity3 but not ACE I/D gene variants with elite rugby union player status and playing position.

answer: @entity2


abstract: PURPOSE: To determine whether the volume of a @entity1 's breast is correlated with reliable daily setup in treatment of @entity0 with a helical tomotherapy treatment unit. METHODS AND MATERIALS: Thirty-six consecutive @entity1 with @entity0 were treated on a helical tomotherapy unit. During simulation, kilovoltage CT images were obtained for treatment planning. These were fused with daily megavoltage CT scans, and after setup based on skin marks and laser alignment the necessary shifts were carried out. The magnitude of daily shifts (in millimeters) was retrospectively obtained from the daily image fusions, and the breast volume was obtained from the treatment plan. A total of 873 fusion scans were reviewed. Random error for absolute and directional daily shifts was evaluated for correlation to volume. Variation over time was also evaluated. RESULTS: Mean (SD) random shift for all @entity1 in the lateral, longitudinal, and vertical directions was 2.7 (2.0), 3.1 (1.5), and 3.2 (2.6) mm, respectively. Mean (SD) absolute distance shifted was 6.0 (3.5) mm. There was no significant correlation between mean absolute or mean directional daily shift and breast volume (0.08, 0.08, 0.22, and 0.07, respectively). There was no correlation between setup variation and time. CONCLUSIONS: In this cohort, there was no correlation between breast volume and degree of daily shift. There was no correlation between time course and setup variation. Therefore, setup variation does not improve or degrade with repeated treatment setups.

title: Effect of breast volume on treatment reproducibility on a tomotherapy unit in the treatment of XXXX .

answer: @entity0


abstract: Our objective was to test the hypothesis that aberrantly modified forms of @entity3 dismutase ( @entity4 ) influence the disease course for @entity5 ( @entity5 ). We probed for anti- @entity4 antibodies (IgM and IgG) against both the normal and aberrantly oxidized- @entity4 (SODox) antigens in sera from @entity0 with @entity5 , subjects diagnosed with other @entity1 and healthy individuals, and correlated the levels of these antibodies to disease duration and/or severity. Anti- @entity4 antibodies were detected in all cohorts; however, a subset of    5-10% of @entity5 cases exhibited elevated levels of anti- @entity4 antibodies. Those @entity5 cases with relatively high levels of IgM antibodies against SODox exhibit a longer survival of 6.4 years, compared to subjects lacking these antibodies. By contrast, @entity5 subjects expressing higher levels of IgG antibodies reactive for the normal WT- @entity4 antigen exhibit a shorter survival of 4.1 years. Anti- @entity4 antibody levels did not correlate with disease severity in either the @entity2 cohorts. In conclusion, the association of longer survival with elevated levels of anti-SODox antibodies suggests that these antibodies may be protective. By extension, these data implicate aberrantly modified forms of WT- @entity4 (e.g. oxidized @entity4 ) in @entity5 pathogenesis. In contrast, an immune response against the normal WT- @entity4 appears to be disadvantageous in @entity5 , possibly because the anti-oxidizing activity of normal WT- @entity4 is beneficial to @entity5 individuals.

title: Anti- XXXX dismutase antibodies are associated with survival in @entity0 with @entity5 .

answer: @entity3


abstract: INTRODUCTION: In vivo, initial platelet activation is likely caused by platelet contacts with collagen in the subendothelium or from the small amounts of @entity0 formed by the tissue factor/factor VIIa complex. Our aim was to study the coagulative role of @entity1 released by the platelets after activation with strong stimuli such as collagen and/or @entity0 , and the relative importance of the platelet @entity1 receptors @entity4 and @entity2 . MATERIALS AND METHODS: We used 10 Hz free oscillation rheometry to measure clotting time, clot elasticity and fibrinolysis resistance of non-anticoagulated whole blood. The platelets were activated with a collagen-related peptide (CRP), with the @entity3 @entity0 receptor activating peptide TRAP-6 or by @entity0 , the latter generated by small amounts of thromboplastin. To inhibit the platelet @entity1 receptors, we used the @entity4 antagonist @entity5 and the @entity2 antagonist @entity6 . RESULTS: Both antagonists significantly retarded the clotting induced by CRP. The effects were most pronounced with @entity6 . For TRAP-6, the same trend was seen, but the retardation was only significant with @entity6 . Clotting induced by small amounts of thromboplastin was not affected by any @entity1 -receptor antagonist. Addition of both antagonists did not change the results as compared to samples with @entity6 alone. Nor did the antagonists, one at a time or in concert, effect fibrinolysis or the elastic properties of the clot. CONCLUSION: We conclude that @entity1 -receptor inhibition prolongs the clotting time for whole blood activated by CRP, but that it does not affect the properties of the subsequently formed coagulum.

title: Effects of inhibition of XXXX and @entity2 on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry.

answer: @entity4


abstract: 40 @entity0 (39 @entity0 and 1 @entity0 ) aged 13-66 years (mean 35.9 years) with solitary benign non-toxic thyroid nodule confirmed by clinical and hormonal examination, ultrasonography and fine needle aspiration biopsy, were treated with intranodular percutaneous 96% @entity3 injection, performed under ultrasound guidance. There were 34 @entity0 with solid nodule (including 4 @entity0 ) with solitary nodule in recurrent goitre after thyroidectomy) and 6 @entity0 with cyst. The nodules were 7-60 mm (mean 31 mm) in diameter. 1 ml of @entity3 was instilled per 1 cm3 of nodule tissue. 1-5 (mean 2.6) sessions were conducted at one month intervals. The early follow-up evaluation of the results (the evaluation of nodule size by means of clinical and ultrasound examination) was performed after 6 months, and the long-term one after 2 years since the last injection. A morphological evaluation was conducted according to the following scale: 1--nodule disappearance, 2--cicatricial nodule (solid structure in the ultrasonography and less than 0.5 cm in diameter), 3--nodule smaller by [symbol: see text] 50% of initial dimensions, 4--nodule smaller by < 50% of initial dimensions. A final follow-up evaluation revealed: nodule disappearance in 15 (37.5%) @entity0 (Group 1), cicatricial nodule in 10 (25%) @entity0 (Group 2), nodules smaller by [symbol: see text] 50% of initial dimensions in 7 (17.5%) @entity0 (Group 3) and nodules smaller by < 50% of initial dimensions in 8 (20%) @entity0 (Group 4). The results in Group 1 and 2 were defined as good (25 @entity0 --62.5%), in Group 3 as satisfactory (17.5%) and in Group 4 as @entity4 . The results of treatment of cysts and nodules in recurrent goitre were good or satisfactory. The following complications were observed: 1) @entity1 during and after the injection in 29 (72.5%) @entity0 , 2) subfebrile body temperature ap to 38 degrees C in 4 (10%) @entity0 and fever up to 39 degrees C on the 1-st day after the injection in 2 (5%) @entity0 , 3) ecchymosis in 1 (2.5%) @entity0 , 4) temporary @entity6 in 2 (5%) @entity0 , 6) temporary unilateral vocal @entity2 and @entity5 in 1 (2.5%) @entity0 . It seems that percutaneous @entity3 injection can be useful treatment method of solitary benign non-toxic thyroid nodules, both cysts and solid nodules, in @entity0 who do not consent to surgical treatment or with contraindications to an operation.

title: [The treatment of solitary thyroid nodules in non-toxic goiter with 96% XXXX injections].

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficacy of topical administration of a 2% solution of @entity0 (CsA) for treatment of @entity1 with @entity4 sicca (KCS) and to correlate results with histopathologic characteristics and local cellular immunity of the gland of the third eyelid. ANIMALS: 24 @entity1 with bilateral KCS. PROCEDURE: Lacrimal secretion was measured, using Schirmer tear test (STT) strips. Leukocyte and T-lymphocyte subsets were determined in blood samples. Histopathologic changes as well as @entity6 +, CD8+, and @entity5 esterase-positive (ANAE+) lymphocytes were evaluated. RESULTS: Clinical signs resolved at the end of 1 month in conjunction with significantly increased STT values, compared with baseline values. Fifteen and 30 days after discontinuation of CsA treatment, a decrease was observed in STT values in both eyes; however, only values for the right eye were significantly different. There was a significant decrease in the number of lymphocytes and ANAE+ lymphocytes 15 and 30 days after discontinuation of CsA treatment, compared with baseline values. Differences were not observed in number of @entity6 + lymphocytes among treatment groups. However, there was a significant decrease in number of CD8+ lymphocytes with reversal of the @entity6 +:CD8+ in both eyes after CsA treatment for 30 days, compared with the control group. Increased secretory activity and @entity3 were characteristic histopathologic findings. CONCLUSIONS AND CLINICAL RELEVANCE: Topical administration of a 2% solution of @entity2 was effective for the treatment of @entity1 with KCS. Strict follow-up monitoring is required after the cessation of treatment because of the possibility of recurrence of KCS.

title: Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% @entity0 for treatment of @entity1 with XXXX sicca.

answer: @entity4


abstract: BACKGROUND: The anti-programmed death-1 (anti-PD-1) therapy nivolumab has significant clinical activity in @entity0 with @entity4 . However, little is known about the safety and outcomes in patients receiving anti-PD-1 therapy and stereotactic radiation for the treatment of brain metastases (BMs). @entity0 AND METHODS: Data were analyzed retrospectively from two prospective nivolumab protocols enrolling 160 @entity0 with advanced resected and unresectable @entity4 at a single institution. @entity0 were included if BMs were diagnosed and treated with stereotactic radiation within 6 months of receiving nivolumab. The primary end point of this study was @entity8 ; secondary end points included BM control and survival. RESULTS: Twenty-six @entity0 with a total of 73 BMs treated over 30 sessions were identified. Radiation was administered before, during and after nivolumab in 33 lesions (45%), 5 lesions (7%), and 35 lesions (48%), respectively. All BMs were treated with stereotactic radiosurgery (SRS) in a single session except 12 BMs treated with fractionated stereotactic radiation therapy, nine of which were in the postoperative setting. One @entity0 experienced grade 2 @entity2 following SRS with symptomatic relief with @entity5 treatment. No other treatment-related neurologic @entity3 or scalp reactions were reported. Eight (11%) local BM failures with a >= 20% increase in volume were noted. Of these lesions, @entity6 was noted in 4, and @entity1 was noted in 7. Kaplan-Meier estimates for local BM control following radiation at 6 and 12 months were 91% and 85%, respectively. Median @entity7 ( @entity7 ) from the date of stereotactic radiation and nivolumab initiation was 11.8 and 12.0 months, respectively, in @entity0 receiving nivolumab for unresected disease (median @entity7 was not reached in @entity0 treated in the resected setting). CONCLUSIONS: In our series, stereotactic radiation to @entity4 BMs is well tolerated in @entity0 who received nivolumab. BM control and @entity7 appear prolonged compared with standard current treatment. Prospective evaluation is warranted.

title: Clinical outcomes of XXXX brain metastases treated with stereotactic radiation and anti-PD-1 therapy.

answer: @entity4


abstract: INTRODUCTION: @entity3 is common in @entity0 but is rare in the elderly. It often presents with a constellation of signs and symptoms similar to routine @entity2 . We present the case of an elderly @entity0 with @entity3 containing a @entity6 and provide clinical insights. PRESENTATION OF CASE: An-84-year old @entity0 was admitted with an incarcerated @entity4 . Both testes were absent on palpation of the scrotum. After reduction of the @entity4 , computed tomography scan revealed a round lesion in the @entity4 , which was suspected to be the ectopic @entity5 . Laparoscopic exploration was performed in combination with an open anterior approach. The @entity4 orifice was the right internal inguinal ring, and the inguinal canal was obliterated by adhesions because the spermatic cord did not pass through it. The ectopic @entity5 was resected with the @entity4 repaired with a KUGEL    patch (Bard, USA). DISCUSSION: Laparoscopic exploration was useful to delineate the anatomy of this unusual inguinal @entity4 . The open anterior approach was necessary to dissect the @entity4 . Pathological findings revealed @entity1 cells with clear cytoplasm in the resected @entity5 , diagnosed as a @entity6 . CONCLUSION: The combination of laparoscopic and anterior approaches facilitated the surgical treatment of an unusual @entity3 . The resected ectopic @entity5 should undergo thorough histopathologic examination.

title: An XXXX with a @entity6 in an elderly @entity0 : A case report.

answer: @entity3


abstract: OBJECTIVE: To describe provider practice patterns in the diagnosis and treatment of Nursing Home-Acquired @entity1 (NHAP) and to document associations with cure, mortality, and transfer. DESIGN: A retrospective cohort. SETTING: Six nursing homes in Seattle, Washington. @entity0 : A total of 94 @entity0 , 65 years of age or older (mean 83 +/- SD 9), in whom the diagnosis of @entity1 was documented in the nursing home medical record between July 1, 1994, and June 6, 1995. MEASUREMENTS: Multivariate logistic regression was used to assess the relationship between descriptive, diagnostic, or therapeutic measures and three outcomes, cure, 30-day mortality, and hospital transfer. RESULTS: Ninety-four episodes of @entity1 were identified. Allowing for more than one outcome per @entity0 , there were 71 (75.5%) cures, 16 (17%) deaths, and nine (9.6%) transfers. Eighty-five percent of @entity0 identified as having NHAP by their providers had chest X-rays (CXRs), and 69% had physical examinations. Sputum examination was ordered in 5%, blood cultures in 6%, and white blood cell counts in 33% of @entity0 . In multivariate analysis, @entity0 with functional decline were more likely to die (Odds Ratio (OR) 36.5 (95% CI 6.1, 220)). @entity2 was a risk factor for mortality (OR 6.8 l (CI 1.8, 26)) and transfer (OR 7.5 (CI 1.2, 46)). Those @entity0 receiving only oral antibiotics (OR 3.2 (CI 1.1, 9.7)) were more likely to be cured. Length of therapy >1 week was also associated with cure (OR 2.9 (CI 1.0, 8.6)). Providers with Certificate of Added Qualifications (CAQ) in Geriatric Medicine were more likely to achieve cure (OR 3.1 (CI 1.0, 9.0)). CONCLUSIONS: Most @entity0 with NHAP had diagnostic CXRs and physical examinations. In multivariate analysis, @entity3 was more likely to occur in @entity0 with @entity2 . Cure was associated with the use of oral antibiotics alone and with care by providers with CAQ in Geriatric Medicine.

title: Provider practice patterns in nursing home-acquired XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity3 is an @entity1 . As an inflammatory molecule, @entity10 ( @entity10 ) plays a direct role in atherogenesis. It is known that the elevated plasma @entity4 ( @entity6 ) level is an independent risk factor for @entity3 . We previously reported that @entity6 produces a pro-inflammatory effect by inducing @entity10 expression in vascular smooth muscle cells (VSMCs). In the present study, we observed effect of @entity9 on @entity6 -induced @entity10 expression in @entity2 VSMCs and molecular mechanisms. The in vitro results showed that pretreatment of VSMCs with @entity9 inhibited @entity6 -induced mRNA and protein expression of @entity10 in a concentration-dependent manner. The in vivo experiments displayed that @entity9 not only inhibited @entity10 expression in the vessel walls in mRNA and protein levels, but also reduced the circulating @entity10 level in hyperhomocysteinemic @entity2 . Further study revealed that @entity9 diminished @entity6 -stimulated generation of reactive @entity0 species (ROS), attenuated @entity6 -activated phosphorylation of @entity5 and @entity8 , and upregulated @entity6 -inhibited expression of @entity7 (PPARy) in VSMCs. These demonstrate that @entity9 is able to inhibit @entity6 -induced @entity10 generation in VSMCs, which is related to interfering with ROS- @entity5 / @entity8 signal pathway and upregulating PPARy expression. The present study provides new evidence for the anti-inflammatory and anti- @entity3 effects of @entity9 .

title: @entity9 Inhibits @entity4 -Induced @entity10 Generation in Vascular Smooth Muscle Cells by Regulating PPARy Expression and ROS- @entity5 / XXXX Signal Pathway.

answer: @entity8


abstract: Recurrence of @entity3 ( @entity3 ) or hemifacial @entity2 (HFS) after microvascular decompression (MVD) is not rare. The prosthesis material eventually adheres to the @entity1 and again transmits arterial pulsation to the nerve. A @entity4 ligature technique using a Gore-Tex tape can be used for the transposition of the offending artery. No prosthesis is necessary once the transposition is complete. This technique requires introduction of either Gore-Tex tape or thread around the artery and suture over the petrous dura, so an adequate working space as if operating in a shallow basin is essential. Therefore, the osteoplastic craniotomy is a little larger than usual with the scalp flap entirely reflected using a semicircular skin incision. The Gore-Tex tape can be directly snared around the artery and sutured over the petrous dura. If this procedure is difficult, a thread can be attached to both ends of the Gore-Tex tape to pass the tape around the vessel. Seven @entity0 with @entity3 and 13 @entity0 with HFS have undergone this surgery. Although the follow-up period is not yet long enough, there has been no case of recurrence. The present technique for MVD can provide complete and permanent transposition of the offending artery.

title: XXXX technique of vascular transposition for microvascular decompression--technical note.

answer: @entity4


abstract: BACKGROUND: @entity5 ( @entity5 ) is a rare condition with a poor outcome. A nationwide survey was conducted to identify the clinical features and outcomes of @entity5 in Japan. METHODS: Data were collected via a questionnaire, which was sent to 353 pediatric/pediatric surgical departments in Japan. RESULTS: Of the 28 @entity0 registered as having a certain diagnosis of @entity5 , 19 (male/female, 3/16) @entity0 were analyzed. All of the @entity0 developed functional @entity3 in the neonatal period and showed a distended bladder and microcolon in the radiological examination. A histopathology assessment of the full-thickness of intestinal specimens showed no pathological abnormalities in all @entity0 . Although various medications were given, the @entity0 did not show significant improvement. Drainage stomas were created in the jejunum (n=11) and colon (n=5). Sixteen @entity0 were maintained by @entity4 ( @entity4 ). Nine @entity0 died of sepsis or @entity2 . The five- and ten-year survival rates were 63% and 57%, respectively. CONCLUSIONS: @entity5 @entity0 developed severe functional @entity1 in the neonatal period and had no specific therapeutic intervention. The majority of @entity5 @entity0 required long-term @entity4 . Small bowel or multivisceral transplantation may be necessary to improve the outcome of this condition.

title: XXXX : A report of a nationwide survey in Japan.

answer: @entity5


abstract: CONTEXT: The current standard for diagnosing @entity2 in @entity0 at risk relies on a transrectal ultrasound-guided biopsy test that is blind to the location of the @entity1 . To increase the accuracy of this diagnostic pathway, a software-based magnetic resonance imaging-ultrasound (MRI-US) fusion targeted biopsy approach has been proposed. OBJECTIVE: Our main objective was to compare the detection rate of clinically significant @entity2 with software-based MRI-US fusion targeted biopsy against standard biopsy. The two strategies were also compared in terms of detection of all @entity1 , sampling utility and efficiency, and rate of serious adverse events. The outcomes of different targeted approaches were also compared. EVIDENCE ACQUISITION: We performed a systematic review of PubMed/Medline, Embase (via Ovid), and Cochrane Review databases in December 2013 following the Preferred Reported Items for Systematic reviews and Meta-analysis statement. The risk of bias was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. EVIDENCE SYNTHESIS: Fourteen papers reporting the outcomes of 15 studies (n=2293; range: 13-582) were included. We found that MRI-US fusion targeted biopsies detect more clinically significant @entity1 (median: 33.3% vs 23.6%; range: 13.2-50% vs 4.8-52%) using fewer cores (median: 9.2 vs 37.1) compared with standard biopsy techniques, respectively. Some studies showed a lower detection rate of all @entity1 (median: 50.5% vs 43.4%; range: 23.7-82.1% vs 14.3-59%). MRI-US fusion targeted biopsy was able to detect some clinically significant @entity1 that would have been missed by using only standard biopsy (median: 9.1%; range: 5-16.2%). It was not possible to determine which of the two biopsy approaches led most to serious adverse events because standard and targeted biopsies were performed in the same session. Software-based MRI-US fusion targeted biopsy detected more clinically significant disease than visual targeted biopsy in the only study reporting on this outcome (20.3% vs 15.1%). CONCLUSIONS: Software-based MRI-US fusion targeted biopsy seems to detect more clinically significant @entity1 deploying fewer cores than standard biopsy. Because there was significant study heterogeneity in @entity0 inclusion, definition of significant @entity1 , and the protocol used to conduct the standard biopsy, these findings need to be confirmed by further large multicentre validating studies. @entity0 SUMMARY: We compared the ability of standard biopsy to diagnose @entity2 against a novel approach using software to overlay the images from magnetic resonance imaging and ultrasound to guide biopsies towards the suspicious areas of the prostate. We found consistent findings showing the superiority of this novel targeted approach, although further high-quality evidence is needed to change current practice.

title: Detection of Clinically Significant XXXX Using Magnetic Resonance Imaging-Ultrasound Fusion Targeted Biopsy: A Systematic Review.

answer: @entity2


abstract: BACKGROUND: Angiogenesis inhibitors have emerged as an effective targeted therapy in the treatment of @entity0 with many @entity1 . One of the most widely used angiogenesis inhibitors is bevacizumab, a neutralizing antibody against @entity2 . The overall risk of @entity4 and @entity3 in @entity0 with @entity1 on bevacizumab therapy is unclear. We performed a systematic review and meta-analysis of published clinical trials of bevacizumab to quantify the risk of @entity4 and @entity3 . METHODS: The databases MEDLINE (OVID, 1966 to June 2006) and Web of Science and abstracts presented at the American Society of Clinical Oncology annual meetings from 2004 through 2006 were searched to identify relevant studies. Eligible studies were randomized controlled trials of @entity0 with @entity1 treated with bevacizumab that described the incidence of @entity4 and @entity3 . Relative risk (RR) was calculated by using the fixed-effects model. RESULTS: A total of 1,850 @entity0 were included in the 7 trials identified from the literature. Bevacizumab was associated with a significant increased risk of @entity4 (RR, 1.4 with low-dose bevacizumab; 95% confidence interval [CI], 1.1 to 1.7; RR, 2.2 with high dose; 95% CI, 1.6 to 2.9). @entity3 also was increased significantly among @entity0 receiving bevacizumab (RR, 3.0 for low dose; 95% CI, 2.2 to 4.2; RR, 7.5 for high dose; 95% CI, 4.2 to 13.4). CONCLUSION: There was a significant dose-dependent increase in risk of @entity4 and @entity3 in @entity0 with @entity1 who received bevacizumab.

title: Risks of @entity4 and @entity3 with bevacizumab, an antibody against XXXX : systematic review and meta-analysis.

answer: @entity2


abstract: PURPOSE: To evaluate the effect of symmetric recession surgery on all four horizontal rectus muscles in the treatment of @entity0 with @entity7 and sensory @entity2 secondary to @entity4 , dyschromatopsia and @entity8 . METHODS: Prospectively, four @entity0 with a diagnosis of @entity7 and eight @entity0 with sensory @entity2 were operated on. The amount of recession was determined according to the ocular alignment of the @entity0 . Electronystagmographic recordings were conducted in every @entity0 pre-operatively and post-operatively, as well as an ophthalmological examination. RESULTS: Mean age of the @entity0 at the time of the first visit was 6.7 +/- 4.2 years (range 9 months to 14 years) and mean age at the time of operation was 8.3 +/- 2.7 years (range 6-14 years). In 8 cases an equal amount of weakening of the four horizontal recti was done, whereas in 2 cases more recession on the lateral recti due to @entity5 and in 2 cases more recession on the medial recti due to @entity6 was performed. Mean follow-up time was 15.8 months (min. 6 months, max. 28 months). Improvement in visual function was achieved in 7 @entity0 . Amplitude decreased in 9 @entity0 . One @entity0 had a @entity1 due to progression of her primary @entity3 . Improvement in head posture was seen in 3 @entity0 and there was no change in the head posture in 2 @entity0 . One @entity0 acquired head posture after surgery. Restriction of motility was seen in none of the @entity0 after surgery in spite of large amounts of recession. Recession of horizontal recti @entity2 and frequency in 81.8% of @entity0 . Improvement in visual function, measured as an increase in visual acuity in terms of Snellen lines, was achieved in 63.6% of @entity0 . CONCLUSION: Symmetric recession of the horizontal rectus muscles is shown to be a successful procedure to perform in @entity2 @entity0 , resulting in an increase in visual acuity and a @entity2 and frequency. It is a reliable alternative to the Kestenbaum operation and is easier to perform surgically.

title: Surgical treatment in XXXX .

answer: @entity2


abstract: BACKGROUND: Surgical resection and adjuvant radiation therapy are standard therapy for soft tissue @entity3 . When the @entity1 approximates bone, periosteal excision may be necessary. It was hypothesized that periosteal stripping and radiation therapy would increase the rate of pathologic @entity2 . METHODS: The soft tissue @entity3 data base at the Memorial Sloan-Kettering Cancer Center was used to identify a consecutive series of 205 @entity0 who were treated over a 15-year period (1982-1997). All @entity0 had a soft tissue @entity3 of the thigh, which was managed by limb-sparing surgery and radiation therapy. @entity0 who had bone invasion by @entity1 or bone resection were not included. RESULTS: Nine @entity0 , including eight @entity0 and one @entity0 , developed a @entity4 in an area of previous radiation and surgery. All nine @entity0 had undergone periosteal excision. The risk of @entity2 , by Kaplan-Meier survivorship, was 29% at 5 years if the resection included periosteum (P < 0.0001). Cox multiple regression analysis showed that periosteal excision was the only independent prognostic factor for the entire set of 205 @entity0 at risk. However, for the subset of 54 @entity0 who had periosteal stripping, two factors were also found to be prognostically important: female gender (P=0.022) and chemotherapy (P=0.020). The risk of @entity2 was 47% and 45%, respectively. The treatment of the @entity2 was difficult. There were four nonunions and three delayed unions. CONCLUSIONS: Periosteal stripping and radiation therapy places the femur at high risk of pathologic @entity2 , especially for female @entity0 and @entity0 undergoing chemotherapy. When practical, the combination of periosteal stripping and radiation should be avoided.

title: Pathologic @entity4 after periosteal excision and radiation for the treatment of soft tissue XXXX .

answer: @entity3