abstract: The class II (Ia) MHC molecules are cell surface proteins that regulate the activation of T cells. B lymphocyte expression of class II molecules has been shown to be influenced by a number of external stimuli. It has been previously demonstrated that treatment of these cells with @entity1 leads to an increase in class II gene transcription at 18 h as well as to an increase in steady state class II mRNA. It has also been previously demonstrated that @entity2 treatment of splenic B cells from athymic @entity0 results in a decrease in steady state mRNA encoding the @entity4 class II protein. This decrease persists for at least 18 h. Nuclear run-on transcription assays now demonstrate that although steady state mRNA levels for @entity4 are decreased by @entity2 treatment of athymic @entity0 lymphocytes, @entity2 does not decrease @entity4 gene transcription, but rather modestly activates transcription of this class II gene. @entity2 and @entity1 have been demonstrated to be synergistic stimuli for a number of genes. Costimulation of splenic lymphocytes from athymic @entity0 with @entity1 plus @entity2 leads to activation of transcription, but the increase in transcription is no more than that seen with @entity1 stimulation alone. However, in costimulated lymphocytes, steady state @entity4 -encoding mRNA levels are intermediate between the increased levels seen with @entity1 stimulation and the decreased levels seen with @entity2 stimulation. Therefore, @entity2 and @entity1 act nonsynergistically in class II gene transcription and the effects of @entity2 in decreasing steady state mRNA are most likely posttranscriptional. An @entity1 -inducible and an @entity2 -inducible @entity3 have been previously identified in splenic lymphocytes from athymic @entity0 . Both nuclear binding proteins form complexes with the same DNA fragments from a control region of the @entity4 gene. These nucleoprotein complexes comigrate under nondenaturing conditions and display identical patterns of binding with a panel of oligonucleotide competitors. Oligonucleotides representing protein binding sites of the @entity1 and @entity2 -induced DNA-binding proteins cross-compete for protein binding. Therefore, the binding proteins induced by @entity2 and @entity1 are likely related, and may function at different efficiencies as activators of @entity4 gene transcription.

title: Role of lipopolysaccharide and XXXX in control of transcription of the class II @entity4 gene.

answer: @entity1


abstract: OBJECTIVE: To study the effects of an acute therapeutic oral intake of @entity6 ) agonist on performance and substrate response during supramaximal exercise in @entity0 . METHODS: 12 healthy moderately trained female volunteers performed a Wingate test after ingestion of placebo ( @entity4 ) and @entity8 ( @entity7 ; 4 mg) according to a double-blind randomised crossover study. Blood samples were collected at rest, at the end of exercise and after 5 (r5), 10 (r10) and 15 (r15) min of passive recovery for @entity9 (ACTH), @entity5 ( @entity5 ), insulin, blood @entity1 and @entity2 measurements. RESULTS: Peak power (PP) and mean power (MP) significantly increased whereas time to peak power was significantly shorter with @entity7 than with @entity4 (p<0.05). No change was observed in the fatigue index. ACTH was not significantly modified but r15 @entity5 significantly decreased (p<0.05) after the intake of @entity7 . Both @entity3 and blood @entity1 were significantly increased by the intake of @entity7 during all the experiments (p<0.01). Blood @entity2 was significantly increased by the intake of @entity7 compared with that of @entity4 (p<0.05) after 10 and 15 min of passive recovery. CONCLUSION: From these data, acute therapeutic oral intake of @entity7 seems to induce, irrespective of the subjects' gender, an improvement in performance during a supramaximal exercise--that is, increase in PP and MP. Further studies are necessary to clarify whether the mechanisms involved in the response to intake of @entity7 are linked to central and/or peripheral pathways.

title: Effects of acute XXXX intake during supramaximal exercise in @entity0 .

answer: @entity8


abstract: BACKGROUND: Two types of @entity3 ( @entity3 ) mutations in exon 19 and exon 21 (ex19del and @entity6 ) are prevalent in @entity1 @entity0 and sensitive to targeted @entity3 inhibition. A resistance mutation in exon 20 ( @entity7 ) has been found to accompany drug treatment when @entity0 relapse. These three mutations are valuable companion diagnostic biomarkers for guiding personalized treatment. Quantitative polymerase chain reaction (qPCR)-based methods have been widely used in the clinic by physicians to guide treatment decisions. The aim of this study was to evaluate the technical and clinical sensitivity and specificity of the droplet digital polymerase chain reaction (ddPCR) method in detecting the three @entity3 mutations in @entity0 with @entity1 . METHODS: Genomic DNA from H1975 and PC-9 cells, as well as 92 normal @entity0 blood specimens, was used to determine the technical sensitivity and specificity of the ddPCR assays. Genomic DNA of @entity2 -fixed, @entity4 -embedded specimens from 78 Chinese @entity0 with @entity5 were assayed using both qPCR and ddPCR. RESULTS: The three ddPCR assays had a limit of detection of 0.02% and a wide dynamic range from 1 to 20,000 copies measurement. The @entity6 and ex19del assays had a 0% background level in the technical and clinical settings. The @entity7 assay appeared to have a 0.03% technical background. The ddPCR assays were robust for correct determination of @entity3 mutation status in @entity0 , and the dynamic range appeared to be better than qPCR methods. The ddPCR assay for @entity7 could detect @entity0 samples that the qPCR method failed to detect. About 49% of this @entity0 cohort had @entity3 mutations ( @entity6 , 15.4%; ex19del, 29.5%; @entity7 , 6.4%). Two @entity0 with the ex19del mutation also had a na  ve @entity7 mutation. CONCLUSION: These data suggest that the ddPCR method could be useful in the personalized treatment of @entity0 with @entity1 .

title: Detection of XXXX mutation in @entity1 by droplet digital polymerase chain reaction.

answer: @entity3


abstract: OBJECTIVE: Investigate the expression and significance of @entity2 in @entity4 . METHODS: Retrospective analysis of clinical data for 151 @entity4 @entity0 (BR group), complete blood count and blood bacterial culture etc.; in addition, 150 general @entity3 @entity0 (BI group) and 135 @entity0 in healthy physical condition upon testing (NC group) are selected respectively as the control groups to comparatively study expression of white blood cells and @entity2 for @entity4 @entity0 . Adopt t test to compare measurement data. RESULTS: In comparison with BI group, WBC, NE, EO, MO, NE% and EO% in BR group are reduced but LY, LY% and MO% are increased and such difference shows statistical significance (P<0.01). In comparison with NC group, difference of WBC and NE in BR group shows no statistical significance (P>0.05). NE%, EO and EO% are reduced but MO, LY% and MO% are increased and such difference shows statistical significance (P<0.01). LY is increased and the difference shows statistical significance (P<0.05). White blood cell count is normal or is reduced among most of @entity4 @entity0 , accounting for 90.73% (137/151); the @entity0 whose @entity2 are reduced account for 75.50% (114/151) and those whose @entity2 disappear are about 18.54% (28/151). CONCLUSION: There is an incidence rate of @entity2 decrease or disappearance in @entity4 and it shows the indication significance in the diagnosis of @entity1 .

title: Expression of @entity2 be beneficial to early clinical diagnosis of XXXX .

answer: @entity4


abstract: OBJECTIVES: The aim of our study is to analyze the clinicopathological characteristics and treatment options for @entity3 with multifocality and investigated whether the number of foci in @entity3 with multifocality can predict central lymph node @entity1 . Methods Records of 329 consecutive PTMC @entity0 with multifocality, and who were treated surgically between 2003 and 2014 were reviewed. @entity0 with multifocality were identified by histopathology. The number of foci, size of the @entity2 , presence of extrathyroidal invasion, infiltration, and other clinicopathological parameters were collected and analyzed for all the cases. RESULTS: Univariate analysis, age, sex, maximum @entity2 size, and extrathyroidal invasion were found to be significant prognostic factors (P = 0.001, 0.020, < 0.001, 0.043; respectively). Multivariate analysis found that age, sex, and maximum @entity2 size were independent prognostic factors for CLNM in PTMCs. Among them, Male @entity0 (odds ratio 1.887; 95% confidence interval [CI] 1.053-3.380) and with maximum @entity2 size > 0.5 cm (odds ratio 2.819; 95% CI 1.721-4.616) were risk factors for increased incidence of CLNM. @entity0 >=  45 years (odds ratio 0. 497; 95% CI 0.309-0.800) were less likely to present with CLNM. However, extrathyroid invasion was not an independent predictor of CLNM according to our results. PTMCs with 2, 3, >=  4 foci had a significantly greater risk of CLNM (odds ratio 1.675, 2.360, 2.703; 95% CI 1.195-2.347, 1.425-3.906, 1.411-5.178; respectively) compared to PTMCs with unifocality. CONCLUSIONS: Foci numbers were linked to an increased incidence of central lymph node @entity1 in @entity3 with multifocality, and we could choose to perform more radical treatment in @entity0 with multifocality.

title: Using foci number to predict central lymph node @entity1 of XXXX with multifocality.

answer: @entity3


abstract: BACKGROUND _ AIMS: @entity2 ( @entity2 ) score has been extensively used to prioritize @entity0 for liver transplantation and determine their prognosis, but with limited predictive value. @entity3 may correlate with increased mortality after liver transplant. In this study, two autonomic biomarkers, complexity and deceleration capacity, were added to the predicting model for 1-year mortality after liver transplantation. METHODS: In all, 30 @entity0 with end-stage @entity1 awaiting liver transplantation were included. Complexity and deceleration capacity were calculated by multi-scale entropy and phase-rectified signal averaging, respectively. Different combinations of autonomic factors and @entity2 score were used to predict mortality rate of liver transplant after 1-year follow-up. Receiver-operating characteristics curve analysis was performed to determine clinical predictability. Area under the receiver-operating characteristics curve represents the overall accuracy. RESULTS: The 1-year mortality rate was 16.7% (5/30). The overall accuracy of @entity2 score used for predicting mortality after liver transplantation was 0.752. By adding complexity and deceleration capacity into the predicting model, the accuracy increased to 0.912. Notably, the accuracy of the prediction using complexity and deceleration capacity alone was 0.912. CONCLUSION: Complexity and deceleration capacity, which represent different dynamical properties of a @entity0 autonomic system, are critical factors for predicting mortality rate of liver transplantation. We recommend that these pre-operative autonomic factors may be helpful as critical adjuncts to predicting model of mortality rate in prioritizing organ allocation.

title: The role of XXXX in predicting 1-year mortality after liver transplantation.

answer: @entity3


abstract: OBJECTIVE: @entity6 (Lotronex), a potent selective @entity3 (3) receptor antagonist, was approved in February, 2000 in the United States for the treatment of @entity2 -predominant @entity5 ( @entity5 ) in @entity0 . Marketing was suspended in November, 2000, after reports of @entity1 and serious complications of @entity4 . We sought to compare the incidence of @entity1 , hospitalized complications of @entity4 , and bowel surgery among alosetron users and a cohort of @entity0 with @entity5 who did not use @entity6 . METHODS: We sought outcomes of @entity1 , hospitalized complications of @entity4 , and bowel surgery in 3,631 Lotronex users and 2,480 comparison @entity5 subjects using diagnoses, procedures, and drugs recorded in the UnitedHealthcare insurance claims database, and validated these by chart review. The initial assessment was to last for 3 yr beginning with the start of alosetron treatment and was to include 10,000 Lotronex users; however, the observation period ended by December 31, 2000, after suspension of marketing. RESULTS: There were 3631 alosetron users among members of UnitedHealthcare from March through December, 2000, and we identified 2480 comparison @entity5 -only @entity0 ; follow-up time averaged about 5 months in both groups. There were no instances of @entity1 in either cohort. Thirty instances of bowel surgery occurred, giving rates of 10.2/1000 @entity0 -yr in the alosetron cohort and 11.8/1000 @entity0 -yr in the @entity5 /no alosetron cohort. There were three cases of hospitalized complications of @entity4 . The incidence rates were essentially the same in alosetron users (1.24/1000 @entity0 -yr) and in @entity5 @entity0 with no alosetron use (0.92/1000 @entity0 -yr). CONCLUSIONS: Alosetron users did not differ from @entity5 @entity0 not using alosetron in the incidence of bowel surgery or hospitalized complications of @entity4 ; there were no cases of @entity1 . The statistical upper limit of @entity1 rates in alosetron users was 2.28/1000 @entity0 -yr. Because of the market withdrawal, the size of the cohort and the duration of follow-up were smaller than originally planned; consequently, the statements about the safety of alosetron were necessarily limited. On June 7, 2002, the Food and Drug Administration approved alosetron for reintroduction in the U.S. market for @entity0 with severe @entity2 -related @entity5 .

title: Incidence of @entity1 , hospitalized complications of @entity4 , and bowel surgery in relation to use of XXXX .

answer: @entity6


abstract: @entity3 ( @entity3 ) features translocations linking c-myc to an Ig locus. Breakpoints in the H chain locus ( @entity4 ) stand either close to J(H) or within switch regions and always link c-myc to the 3' @entity4 locus control region (3' LCR). To test the hypothesis that the 3' LCR alone was sufficient to deregulate c-myc, we generated @entity0 carrying a 3' LCR-driven c-myc transgene and specifically up-regulating c-myc in B cells. Splenic B cells from @entity0 proliferated exaggeratedly in response to various signals had an elevated apoptosis rate but normal B220/IgM/IgD expression. Although all Ig levels were lowered in vivo, class switching and Ig secretion proved normal in vitro. Beginning at the age of 12 wk, @entity0 developed @entity2 with an overall incidence of 80% by 40 wk. @entity2 were B220(+)IgM(+)IgD(+) with the @entity3 "starry sky" appearance. Gene expression profiles revealed broad alterations in the proliferation program and the Ras-p21 pathway. Our study demonstrates that 3' @entity4 enhancers alone can deregulate c-myc and initiate the development of @entity1 . The rapid and constant occurrence of @entity1 in this model makes it valuable for the understanding and the potential therapeutic manipulation of c-myc oncogenicity in vivo.

title: The 3' XXXX locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype.

answer: @entity4


abstract: OBJECTIVES: @entity3 and long-term opioid use may lead to a persistent deficit in hedonic capacity, characterized by increased sensitivity to aversive states and insensitivity to natural rewards. Dispositional mindfulness has been linked with improved emotion regulation and @entity1 coping. The aim of the current study was to examine associations between dispositional mindfulness, hedonic capacity, and @entity1 -related interference in an opioid-using @entity3 sample. METHODS: Data were obtained from a sample of 115 @entity3 @entity0 on long-term opioid therapy (68% females, M age=48.3, SD=13.6) who completed the Five Facet Mindfulness Questionnaire (FFMQ), the Snaith-Hamilton Anhedonia and Pleasure Scale (SHAPS), the Brief Pain Inventory, and a psychiatric assessment of major @entity2 . Bivariate correlations, hierarchical multiple regression, and path analysis were used to determine whether dispositional mindfulness scores (FFMQ) predicted variance in hedonic capacity (SHAPS), and whether hedonic capacity mediated the association between mindfulness and @entity1 interference. RESULTS: We observed a significant positive correlation between dispositional mindfulness and hedonic capacity scores (r=0.33, P<0.001). Hierarchical regression indicated that after controlling for @entity1 interference and major @entity2 diagnosis, dispositional mindfulness explained a significant portion of variance in hedonic capacity (b=0.30, P<0.01). The association between dispositional mindfulness and @entity1 interference was mediated by hedonic capacity ( @entity4 , @entity5 ; 95% CI, -0.004 to -0.024, full model R=0.39). DISCUSSION: Findings indicate that dispositional mindfulness was associated with hedonic capacity among this @entity3 sample. In light of this association, it is plausible that interventions that increase mindfulness may reduce @entity1 among opioid-using @entity0 by enhancing hedonic capacity.

title: Mindfulness is Associated With Increased Hedonic Capacity Among @entity3 XXXX Receiving Extended Opioid Pharmacotherapy.

answer: @entity0


abstract: @entity0 with @entity2 , who have disturbances in mood, thought processes and behavior, experience impairment in day-to-day functioning. Primary caregivers have tried to become involved in caring for @entity0 with @entity2 by coordination with community @entity1 nurses. Community @entity1 nurses have an important role to play in supporting families in this care, especially primary caregivers. The purpose of the present study was to explore the relationship between Thai community @entity1 nurses and primary caregivers of @entity0 with @entity2 . Grounded theory methodology was used to examine the process with which community @entity1 nurses work together with primary caregivers. Purposive sampling and theoretical sampling were used. Data were collected from 34 informants, including 17 community @entity1 nurses and 17 primary caregivers through in-depth interviews, observation, and field notes. Data was analyzed using constant and comparative methods by Glaser (1978). The study revealed that building collaboration in the care of @entity0 with @entity2 involved coordinating both community @entity1 nurses and primary caregivers in a process that consists of five major stages. In the first stage, community @entity1 nurses and primary caregivers used strategies to establish trust in each other before the next stage, which engaged their concerns and needs. Later, the stages of mutual preparation for caregiving, cooperating on @entity0 care and monitoring outcomes were jointly employed in order to promote a healthy family life for @entity0 . The study concludes by suggesting guidelines and giving insights into ways of helping primary caregivers and their @entity0 with @entity2 .

title: Building collaboration in caring for @entity0 with XXXX .

answer: @entity2


abstract: OBJECT: @entity6 affects one in 10 @entity0 born to mothers who ingest @entity4 regularly during pregnancy. It has been described as producing a combination of typical @entity2 and major @entity5 . @entity1 is caused by premature fusion of the metopic suture and has not previously been described as a typical feature of the syndrome. The authors reviewed the cases of 2,220 @entity0 with @entity1 to examine the effect of maternal @entity4 use on the fetus. METHODS: Case files of all 2,220 @entity0 were reviewed. The type and severity of each @entity0 's @entity1 was assessed. Information about maternal health and medication use was obtained, and family interviews were conducted. @entity0 underwent mental development assessment performed using standard tests both pre- and postoperatively. Detailed maternal health information was obtained in 1,676 cases. Of these, 17 mothers were found to have undergone regular treatment with @entity4 monotherapy at the time of their pregnancies. No other antiepileptic medical regimen was found. All 17 @entity0 exhibited @entity1 . These @entity0 ' intelligence quotients (JQs) at the time of the most recent follow-up examination ranged from 45 to 100, with a mean of 75; IQs were significantly higher in @entity0 who underwent surgery before reaching 6 months of age. CONCLUSIONS: Ideally any pregnancy in a @entity0 being treated for @entity3 should be planned, and both an obstetrician and a neurologist should be consulted. In @entity0 born with @entity6 , it is important to be aware of the possibility of metopic suture synostosis, which we believe should be considered part of the syndrome, because early surgical intervention may improve cognitive outcome.

title: XXXX and fetal exposure to @entity4 .

answer: @entity1


abstract: OBJECTIVES: The study evaluated the outcome of the treatment of @entity0 who sustained high-energy, compression-type injuries of the distal radius. DESIGN: The retrospective study evaluated the outcome of reduction and plating of the lunate facet in conjunction with standard external fixation. SETTING: A Level I @entity1 center. @entity0 : Inclusion criteria for study participation included: 1) age between 18 and 65 years of age with no evidence of concomitant @entity4 ; and 2) a 3- or 4-part compression type @entity2 of the distal radius with residual displacement of the palmar lunate facet despite reduction of the dorsal cortex by the application of an external fixator. INTERVENTION: @entity2 were treated with palmar plating of the depressed lunate facet combined with dorsal external fixation. MAIN OUTCOME MEASUREMENTS: Posttreatment evaluations consisted of measurements of range of motion, grip strength, radiographic evaluations, and completion of Disability of Arm, Shoulder, and Hand questionnaires. RESULTS: Three months after surgery, 20 of 21 @entity0 exhibited full range of motion at the @entity3 / @entity5 joints. At the 2-year follow-up, an average palmar tilt of +1.0 degrees, radial inclination of 24 degrees, radial length of 12 mm, ulnar variance of 0.5 mm, intra-articular gap of 0.1 mm, and intra-articular step-off of 0.3 mm was documented. Using the Garland and Werley rating system, results were rated as excellent or good for 18 wrists, fair for 2 wrists, and poor for 1 wrist. Mean Disability of Arm, Shoulder, and Hand functional scores and athletic scores improved at 6 months. CONCLUSIONS: Reduction and plating of the lunate facet in conjunction with standard external fixation permits: 1) visualization and reduction of the palmar lunate facet; and 2) reduction of palmar tilt to neutral tilt without significant radial shortening. This technique should be considered as an acceptable option in the treatment of high-energy @entity2 of the distal radius.

title: Results of palmar plating of the lunate facet combined with external fixation for the treatment of high-energy compression XXXX of the distal radius.

answer: @entity2


abstract: @entity1 receptors (NRs) play an important role in basal ganglia function. By using in situ hybridization with @entity2 probes, we investigated the regional and cellular distribution of NR subunit mRNA expression in the @entity0 basal ganglia: caudate nucleus, putamen, lateral globus pallidus (LGP), and medial globus pallidus (MGP). Analysis of both film autoradiograms and emulsion-dipped slides revealed distinct distribution patterns for each subunit. On film autoradiograms, the signal for @entity3 , @entity5 , and @entity7 in the striatum (STR) was higher than in globus pallidus (GP). The @entity6 probe gave a stronger signal in GP than in STR. For @entity4 we found a signal in all regions. Analysis of emulsion-dipped sections demonstrated that in striatal neurons, the @entity5 signal was higher than in GP neurons. In GP neurons, @entity6 was more abundant than in striatal neurons. Despite the relatively low signal on film for @entity7 in GP, we found a slightly higher signal in GP per neuron than in STR since in the pallidal areas neurons were sparse but intensely labeled. @entity3 and @entity4 were more evenly distributed over neurons of STR and GP Between the different parts of STR and GP, we observed only minor differences in the expression of NRs. In MGP a subpopulation of neurons exhibiting low @entity6 signals could be separated from the majority of neurons showing an intense @entity6 signal. Since the physiological properties of NRs are dependent on subunit composition, these data suggest a high degree of regional specialization of NR properties in the @entity0 basal ganglia.

title: Expression of @entity1 receptor subunit mRNAs in the XXXX brain: striatum and globus pallidus.

answer: @entity0


abstract: The increase of laparoscopic cholecystectomy has resulted in an increase of @entity1 . The purpose of this article is to define the types of injury, their occurrence and frequency, and their management by endoscopic and surgical techniques. Three investigations were included in the present study. 1. A 3-year retrospective study among 29 hospitals with 25,007 laparoscopic cholecystectomies. 2. An 8-year prospective study at our institution of 6488 @entity0 . 3. A prospective endoscopic study of 94 @entity0 with injuries and strictures of the common bile duct (CBD) after laparoscopic cholecystectomy. A special classification for @entity1 was developed. Among 25,007 @entity0 from 29 hospitals, a total of 74 lesions were detected with an incidence of 0.29%. At our institution, 20 cases were seen (0.29%) with type I, II, and III injuries. The 94 cases managed by endoscopic procedure were submitted to endoscopic retrograde cholangiopancreatography (ERCP) and papillotomy, with placement of several stents 5 to 10 F during 8 months. The results of this procedure have been excellent to good in 76% of the cases up to 3 years of follow-up. According to our previous and present experience, @entity1 after laparoscopic procedure are two times higher than after open procedure. The best treatment is the prevention of these injuries by careful surgical technique. If they occur, the best moment to repair them is during surgery. If they are noticed after the operation, endoscopic or surgical procedures can be employed.

title: Treatment of common XXXX during laparoscopic cholecystectomy: endoscopic and surgical management.

answer: @entity1


abstract: PURPOSE: To determine the incidence, predictors, and outcomes of generalized @entity2 (GCSE) in @entity1 ( @entity1 ) @entity0 . METHODS: We conducted a retrospective cross-sectional study of adult @entity0 with acute @entity1 using the 2002-2010 Nationwide Inpatient Sample (NIS) database of USA. We used multivariable logistic regression analyses to identify independent predictors of GCSE in @entity0 with @entity1 and to determine the impact of GCSE on outcomes (in-hospital mortality, length of stay, total hospital charges, and discharge disposition). RESULTS: Among 1,457,869 @entity0 hospitalized with @entity1 , 2315 (0.16%) had GCSE. In-hospital mortality was significantly higher in @entity0 with GCSE (32.5% vs. 9.6%; unadjusted OR 4.54, 95% CI 4.16-4.96; p<0.001; adjusted OR 3.41; 95% CI 3.09-3.76p<0.001). @entity0 with GCSE had longer length of stay (17.3  21.9 vs. 6.8  11.1 days; p<0.001), higher total hospital charges ( 147,415  162,319 vs.  54,041  90,524; p<0.001), and were less likely to be discharged home (19.8% vs. 52.7%; p<0.001). Using multivariable logistic regression analysis, age >35 years (OR 2.15; 95% CI 1.87-2.47), CNS @entity3 (OR 4.86; 95% CI 3.70-6.38), @entity6 (OR 9.54; 95% CI 8.10-11.22), and acute @entity5 (OR 4.09; 95% CI 3.41-4.87) were independent predictors of GCSE in @entity1 @entity0 . @entity4 was an independent negative predictor of GCSE (OR 0.74; 95% CI 0.55-0.99). CONCLUSION: Despite its low incidence, GCSE in @entity1 @entity0 was associated with worse outcomes with threefold higher in-hospital mortality, prolonged hospitalization, higher hospital charges, and worse discharge disposition. Surprisingly, @entity4 is a negative predictor of GCSE in this population.

title: A retrospective cross-sectional study of the prevalence of generalized @entity2 in XXXX : United States 2002-2010.

answer: @entity1


abstract: UNASSIGNED: The present study examined the effects of dietary @entity0 ( @entity1 ) on the growth, intestinal function, immunity and antioxidant capacity of sea @entity2 @entity3 (Selenka). The specific growth rate, intestinal morphology, activity of digestive enzymes, activity and gene expression of lysozyme and antioxidative enzymes of the sea @entity2 were determined after feeding 5 experimental diets with additions of increasing levels of @entity1 (at 0%, 0.4%, 0.8%,1.2% and 1.6%, respectively) for 60 days. We discovered that the specific growth rate of the sea @entity2 in 0.4%, 0.8% and 1.2% groups increased 35.3%, 27.3% and 24.1%, respectively, compared to the control (0%) group with significant differences. Dietary @entity1 can improve the intestinal function of the sea @entity2 by increasing the activities of trypsin and @entity4 in the intestine and the villus height and villus density of the intestine, eventhough significant differences were not observed in some groups. 0.4%-0.8% of dietary @entity1 can significantly increase the activity of lysozyme (LSZ) in the coelomic fluid of the sea @entity2 . Significant improvements were observed on the SOD activity in coelomic fluid of the sea @entity2 fed diets supplemented with 0.4%-1.6% of @entity1 compared to the control group. Similarly, the @entity5 activity in coelomic fluid of the sea @entity2 significantly increased in 0.8%, 1.2% and 1.6% groups compared to the control and 0.4% groups. Change pattern of the activity of @entity5 was consistent with the change pattern of the expression of @entity5 gene, indicating the dietary @entity1 can up-regulate the expression of @entity5 gene and consequently promote the secretion of @entity5 . However, the down-regulation of the expression of SOD gene by dietary @entity1 were observed in almost all of the treatment groups, which is in contrast with the change pattern of the activity of SOD, indicating the negative feedback regulation of the secretion of SOD on the expression of SOD gene. In summary, the suitable supplementation levels of @entity1 in diets of sea @entity2 A.  japonicus are 0.4%-0.8%, based on the effectiveness of dietary @entity1 on the growth, intestinal function, immunity and antioxidant capacity of the sea @entity2 .

title: Regulation of dietary @entity0 on the growth, intestinal function, immunity and antioxidant capacity of sea @entity2 XXXX (Selenka).

answer: @entity3


abstract: BACKGROUND: The fifth edition of the Diagnostic and Statistical Manual of @entity2 ( @entity4 ) was published in May 2013. @entity1 ( @entity1 ) has been structured for the three subtypes of @entity3 ( @entity3 ), but the number of impairment in social and communication dimension is not stated. METHODS: The subjects were 68 @entity0 who visited the Department of Psychology and Development at Nagoya City University Hospital for the first time between the ages of 6 and 15 years old. We retrospectively re-examined the subjects using DSM-IV-TR criteria and @entity4 criteria with two rules (two of three and one of three on the social and communication dimension) and examined the concordance rate. RESULTS: Forty subjects were diagnosed with @entity3 , and 28 were not. The mean @entity3 subject age was 9.4   years, and mean IQ was 84.0 on the Wechsler Intelligence Scale for @entity0 III or 62.7 on the Tanaka-Binet test. Twenty-seven (68%) of the @entity3 subjects were classified with @entity1 using @entity4 criteria when the two of three rule was applied, while 32 (80%) were classified with @entity1 when the one of three rule was applied. All subjects without @entity3 were not diagnosed with @entity1 on @entity4 criteria. CONCLUSION: @entity4 criteria may exclude high functioning and older subjects from @entity1 because they tend to be atypical. The diagnostic procedure for @entity4 criteria is ambiguous, especially in high functioning subjects and those diagnosed at an older age.

title: Concordance of @entity4 and DSM-IV-TR classifications for XXXX .

answer: @entity1


abstract: BACKGROUND: Despite considerable improvement in the treatment of advanced @entity2 , the optimization of efficacy and tolerability remains an important issue. Therefore, we performed a randomized, phase III non-inferiority trial comparing @entity6 plus @entity5 (PT) with @entity6 plus @entity8 (TC) in @entity0 with advanced @entity2 . METHODS: A total of 798 @entity0 with International Federation of Gynecology and Obstetrics stage IIB-IV were randomly assigned to receive six courses of either PT or TC at 3-week intervals. The primary endpoint was the proportion of @entity0 without progression at 2 years. Secondary endpoints included @entity3 , response to treatment, quality of life, and overall and progression-free survival time. Quality of life was evaluated using the European Organization for Research and Treatment of @entity1 quality-of-life questionnaire (QLQ)-C30, version 2.0. Survival curves were calculated using the Kaplan-Meier method, and hazard ratios were estimated using the Cox proportional hazards model. RESULTS: The proportion of @entity0 without progression at 2 years was not statistically significantly different between the two treatment arms (40.0% for PT versus 37.5% for TC, difference = 2.5%, one-sided 95% confidence interval [CI] = - infinity to 8.2%). Median progression-free survival time in the TC arm (17.2 months, 95% CI = 15.2 to 19.3 months) and the PT arm (19.1 months, 95% CI = 16.7 to 21.5 months) were also not statistically significantly different; the same was true of median overall survival time (43.3 months, 95% CI = 37.2 to 47.8 months versus 44.1 months, 95% CI = 40.2 to 49.4 months, for the TC and PT arms, respectively). The TC regimen was associated with a higher frequency of @entity7 , but a lower frequency of @entity4 , than the PT regimen. Mean global quality-of-life scores at the end of treatment were statistically significantly better in the TC arm than in the PT arm (65.25 versus 51.97, respectively; difference = -13.28, 95% CI = -18.88 to -7.68). CONCLUSION: The TC regimen achieved comparable efficacy to the PT regimen but was associated with better tolerability and quality of life, and should, therefore, be considered as an important alternative for standard first-line chemotherapy in @entity0 with advanced @entity2 .

title: A randomized clinical trial of @entity5 / @entity6 versus @entity8 / XXXX as first-line treatment of @entity2 .

answer: @entity6


abstract: INTRODUCTION: Learning capacity may influence an individual's response to @entity4 rehabilitation. However, investigations into the relationship between novel word learning ability and response to @entity5 therapy are lacking. The aim of the present study was to evaluate the novel word learning ability in post- @entity2 @entity4 and to establish the relationship between learning ability and @entity5 treatment outcomes. We also explored the influence of locus of language breakdown on novel word learning ability and @entity5 treatment response. MATERIAL AND METHODS: 30 adults (6F; 24M) with chronic, post- @entity2 @entity4 were recruited to the study. Prior to treatment, @entity0 underwent an assessment of language, which included the @entity3 Test and three baseline confrontation naming probes in order to develop sets of treated and untreated items. We also administered the novel word learning paradigm, in which @entity0 learnt novel names associated with unfamiliar objects and were immediately tested on recall (expressive) and recognition (receptive) tasks. @entity0 completed 48h of Aphasia Language Impairment and Functioning Therapy (Aphasia LIFT) over a 3 week (intensive) or 8 week (distributed) schedule. Therapy primarily targeted the remediation of word @entity1 , so naming of treated and untreated items immediately post-therapy and at 1 month follow-up was used to determine therapeutic response. RESULTS: Performance on recall and recognition tasks demonstrated that @entity0 were able to learn novel words; however, performance was variable and was influenced by @entity0 ' @entity4 severity, lexical-semantic processing and locus of language breakdown. Novel word learning performance was significantly correlated with @entity0 ' response to therapy for treated items at post-therapy. In contrast, @entity0 ' novel word learning performance was not correlated with therapy gains for treated items at 1 month follow-up or for untreated items at either time point. Therapy intensity did not influence treatment outcomes. DISCUSSION: This is the first group study to directly examine the relationship between novel word learning and therapy outcomes for @entity5 rehabilitation in adults with @entity4 . Importantly, we found that novel word learning performance was correlated with therapy outcomes. We propose that novel word learning ability may contribute to the initial acquisition of treatment gains in @entity5 rehabilitation.

title: The relationship between novel word learning and @entity5 treatment success in adults with chronic XXXX .

answer: @entity4


abstract: Side effects of the distal gastrointestinal tract after NSAID use are common and more frequent than previously recognized. Increased @entity3 and @entity2 are often silent but appear after NSAID treatment with most dual COX inhibitors. Other clinical manifestations include: @entity9 , occult @entity5 , @entity13 , protein-loss, @entity12 , @entity6 , @entity14 and strictures due to @entity4 . More common complications are @entity8 and perforation, which represent at least one third of all @entity7 observed with NSAID use. Studies with selective @entity11 inhibitors have shown that, in the short term, these agents do not increase @entity3 or induce @entity9 due to @entity10 and that, when compared to dual COX inhibitors, lower @entity7 may be reduced by 50%. In order to minimize the impact of these side effects, it is important to increase the current standards of suspicion by physicians who treat these @entity0 , since drug discontinuation may further reduce damage, and clinical experience with agents that may prevent or treat distal tract damage is very limited. From this perspective, selective @entity11 inhibitors may be the drugs of choice in the high-risk @entity0 that needs NSAIDs. Another important area of uncertainty is the impact of NSAID use in @entity0 with @entity1 . Data from different animal models of @entity1 suggest that inhibition of both @entity15 and @entity11 derived prostaglandins affects the severity of the @entity2 . However, current epidemiological and clinical data are contradictory. Since many @entity0 .

title: Clinical implications of XXXX and/or @entity11 inhibition for the distal gastrointestinal tract.

answer: @entity15


abstract: OBJECTIVES: To establish the cut-off values for inactive disease, as well as low disease activity (LDA), moderate disease activity (MDA) and high disease activity (HDA) in @entity2 JIA based on the @entity3 Activity Score (JADAS) and assessed with the 10-joint JADAS (JADAS10) and clinical JADAS10 (cJADAS10). METHODS: In a multicentre cross-sectional study consisting of    20% of all @entity0 with JIA in Finland (n = 509), we obtained data on their most recent registered visits between January 2013 and January 2014. We calculated the JADAS10 and cJADAS10 and established the cut-off values of both of these scores using two different receiver operating characteristics-based statistical methods. RESULTS: Of the 509 @entity0 studied, 65.8% were females and 53.8% had @entity1 . The most suitable method for determining cut-off values was the Youden index. In oligoarticular @entity0 , a JADAS10 score of 0-0.5 represented inactive disease, 0.6-2.7 LDA and >= 2.8 MDA. In @entity1 , a JADAS10 score of 0-0.7 represented inactive disease, 0.8-3.9 LDA and >= 4.0 MDA. The cut-off values for HDA were not possible to establish because only two visits fulfilled HDA criteria. CONCLUSION: We established cut-off values for LDA and MDA. A reliable definition for HDA will require more @entity0 . In the clinical setting, both the cJADAS10 and JADAS10 serve equally well both for research and quality control purposes. In the future, uniform clinical disease activity levels should be established. We also suggest revising and validating the criteria for HDA. Valid and robust cut-off values for disease activity levels can guide both clinicians and researchers and equip them for quality control.

title: Finding specific 10-joint @entity3 Activity Score (JADAS10) and clinical JADAS10 cut-off values for disease activity levels in @entity2 juvenile idiopathic XXXX : a Finnish multicentre study.

answer: @entity3


abstract: Latent transforming growth factor (TGF)-beta-binding protein (LTBP) is required for the assembly, secretion, matrix association, and activation of latent TGF-beta complex. To elucidate the cell specific expression of the genes of @entity4 and their splice variants and the factors that regulate the gene expression, we cultured primary @entity0 glomerular endothelial cells (HGEC) under different conditions. Basal expression of @entity4 mRNA was suppressed in HGEC compared to WI-38 @entity0 embryonic lung fibroblasts. High @entity3 , @entity2 , and @entity4 upregulated and @entity1 ( @entity1 ) further downregulated @entity4 mRNA in HGEC. RT-PCR with a primer set for LTBP-1S produced many clones but no clone was gained with a primer set for LTBP-1L. Of 12 clones selected randomly, Sca I mapping and DNA sequencing revealed that only one was LTBP-1S and all the others were LTBP-1Sdelta53. @entity4 , but not high @entity3 , @entity2 or @entity1 , tended to increase LTBP-1Sdelta53 mRNA. In conclusion, HGEC express @entity4 mRNA which is suppressed at basal state but upregulated by high @entity3 , @entity2 , and @entity4 and downregulated by @entity1 . Major splice variant of @entity4 in HGEC was LTBP-1S 53. Modification of LTBP-1S 53 gene in HGEC may abrogate fibrotic action of @entity4 but this requires confirmation.

title: Expression and regulation of latent TGF-beta binding protein-1 transcripts and their splice variants in XXXX glomerular endothelial cells.

answer: @entity0


abstract: The anther (tapetum)-specific gene BcA9 was isolated from Chinese cabbage, @entity4 . ssp. pekinensis cv. Jangwon, using the @entity1 tapetum-specific A9 gene as a probe. The DNA and @entity0 sequences of the coding region of the BcA9 gene showed high homology with A9 genes from @entity1 and @entity2 . However, the DNA sequences of the 5' noncoding (promoter) region were different, except for the sequence from -281 to -89. To test the specific activity of this promoter, a plant expression vector, pGR011, was constructed by fusing the BcA9 promoter and the cytotoxic diphtheria toxin A-chain (DTx-A) gene. Several transgenic plants from cabbage, @entity3 ssp. capitata, were obtained by way of Agrobacterium-mediated transformation. Southern blot analysis indicated that the tapetum-specific BcA9 promoter and DTx-A gene were successfully integrated into the genome of the transgenic cabbage. Under the control of the BcA9 promoter, expression of the cytotoxic DTx-A gene in the tapetal cells of the transgenic plants resulted in male sterile cabbages. Microscopic examination revealed that pollen grains in anthers of the male sterile cabbages had not developed normally, but the vegetative growth and phenotype showed no difference compared to wild-type plants.

title: Induction of male sterile cabbage using a tapetum-specific promoter from XXXX . ssp. pekinensis.

answer: @entity4


abstract: AIMS: This study aimed to: (1) evaluate cognitive function among adults with @entity1 using a computer-administered neuropsychological test; and (2) replicate previously identified differences in processing speed between @entity0 with @entity1 and controls. BACKGROUND: Previous evidence suggests that, compared with controls, adult @entity0 with @entity1 have poorer cognitive functioning across most domains but the most significant deficits appear to be in the area of processing speed. DESIGN: Cross-sectional case-control study conducted from June 2008-June 2010. METHODS: Cognitive functioning was measured using computerized, self-administered, neuropsychological tests among 31 @entity0 with @entity1 and 17 controls matched for age, gender and race. The assessment averaged 30  minutes and scores were recorded for seven computerized tests: verbal and visual memory, finger tapping, symbol digit coding, Stroop test, shifting attention and continuous performance. RESULTS: @entity0 with @entity1 scored 10  76 points lower on the CNS Vital Signs processing speed domain than controls. Although non-significant, @entity0 scored 5  73 points lower on the full index than controls but after adjusting for processing speed, mean scores for @entity0 were 3 points greater compared with controls. Differences in executive functioning and attention were not significant and memory did not differ between groups. CONCLUSION: Using a brief, computer-administered 30-minute neuropsychological test, we were able to replicate previous findings showing a greater than 10-point deficit in processing speed among @entity0 with @entity1 . When differences in processing speed are taken into account, @entity0 perform equally well or better than controls on cognitive tasks.

title: Adults with XXXX may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study.

answer: @entity1


abstract: The dichotomy between @entity1 and @entity3 is, as E. Kraepelin suspected, flawed; no unequivocal separation can be achieved. There are no categories of @entity2 , but only continua of variation. However, the definition of nuclear symptoms by K. Schneider reveals the fundamental characteristics of the core syndrome--it is independent of the environment and constant in incidence across populations that have been separated for thousands of years. The associated genetic variation must be as old as @entity0 and represent a component of diversity that crosses the population as a whole. The fecundity disadvantage that accompanies the syndrome requires a balance in a substantial and universal advantage; this advantage, it is proposed, is the speciation characteristic of language; language and @entity2 have a common evolutionary origin. Language, it is suggested, originated in a critical change on the sex chromosomes (the 'speciation event'--the genetic change that defined the species) occurring in East Africa between 100 and 250 thousand years ago that allowed the two hemispheres to develop with a degree of independence. Language can be understood as bi-hemispheric with one component function--a linear output sequence--confined to the dominant hemisphere--and a second--parallel distributed sampling occurring mainly in the non-dominant hemisphere. This mechanism provides an account of the generativity of language. The significance of nuclear symptoms is that these reflect a breakdown of bi-hemispheric coordination of language, perhaps specifically of the process of 'indexicalisation' (the distinction between 'I' and 'you') of self- versus other-generated references. Nuclear symptoms can be described as 'language at the end of its tether'; the phenomena and population characteristics of the nuclear syndrome of @entity1 thus yield clues to the origin of the species.

title: Is @entity1 the price that XXXX pays for language?

answer: @entity0


abstract: The Wnts are a family of glycoproteins that regulate cell proliferation, fate decisions, and differentiation. In our study, we examined the contribution of Wnts to the development of ventral midbrain (VM) dopaminergic (DA) neurons. Our results show that @entity7 is expressed in DA precursor cells and that @entity7 signaling takes place in these cells, as assessed in TOPGAL [Tcf optimal-promoter beta-galactosidase] reporter @entity0 . We also found that @entity5 , -3a, and -5a expression is differentially regulated during development and that partially purified Wnts distinctively regulate VM development. @entity6 promoted the proliferation of precursor cells expressing the orphan nuclear receptor-related factor 1 ( @entity10 ) but did not increase the number of @entity3 hydroxylase-positive neurons. Instead, @entity12 increased the number of @entity1 midbrain DA neurons in @entity1 embryonic day 14.5 precursor cultures by two distinct mechanisms. @entity5 predominantly increased the proliferation of @entity10 + precursors, up-regulated cyclins D1 and D3, and down-regulated @entity4 and @entity8 mRNAs. In contrast, @entity9 primarily increased the proportion of @entity10 + precursors that acquired a neuronal DA phenotype and up-regulated the expression of @entity11 and c-ret mRNA. Moreover, the soluble @entity2 -rich domain of Frizzled-8 (a Wnt inhibitor) blocked endogenous Wnts and the effects of @entity5 a on proliferation and the acquisition of a DA phenotype in precursor cultures. These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles.

title: Differential regulation of midbrain dopaminergic neuron development by @entity5 , XXXX , and @entity9 .

answer: @entity6