abstract: We report clinical and neuroimaging findings for three @entity0 suffering from @entity6 ( @entity6 ) with focal motor symptoms. These @entity0 initially showed @entity2 and subsequently featured myoclonus and awkward movements in the unilateral upper limb while progressing to paresis. Paresis was noted in the unilateral upper limb. All @entity0 held the unilateral arm flexed at the wrist and elbow, closely adducted to the body and the hand fisted and pronated. No signs of @entity10 , @entity3 or long tract signs were observed, nor any of the initial non-cognitive behavioural changes typical of @entity9 . EEGs of these @entity0 showed marked slowing of basic activity without @entity7 discharges. MRIs showed progressive @entity8 in the contralateral frontoparietal lobes as well as the hippocampal formation. Cases 2 and 3 featured extensive long T2 lesions on MRI. 99mTc-HMPAO-SPECT revealed blood flow hypoperfusion in the corresponding regions. The cerebellum and brain stem showed neither @entity4 nor blood flow hypoperfusion. On the basis of these clinical and neuroimaging observations, the focal motor symptoms were attributed to contralateral frontoparietal cortical @entity5 with or without @entity1 .

title: Report of three cases of XXXX with focal motor symptoms: clinical correlates of neuroimaging findings.

answer: @entity6


abstract: INTRODUCTION: @entity5 ( @entity5 ) is an autoimmunological @entity5 occuring to genetically predisposed individuals. Active @entity5 is accompanied by presence of multiple antibodies. Anti alpha enolase antibodies were reported in @entity2 like @entity3 , @entity4 . Data about its presence and role in @entity5 is avaricious. AIM: The aim of this study was to determine presence of anti alpha enolase antibodies in @entity5 , correlation with gluten exposure, presence of anti tranglutaminase antibodies and Marsh scale. METHODS: Sera from 31 @entity0 with @entity5 (21 females, 10 males) and 6 healthy subjects were collected. Evaluation of @entity5 activity and adherence to gluten free diet were obtained by serology tests (presence of endomyslum antibodies and/or anti transglutamineses in IgA or IgG classes) and histological hallmarks. Anti alpha enolase antibodies were identified in sera using ELISA kit. Titres of anti alpha enolase antibodies were identified among @entity0 with newly diagnosed @entity5 , @entity5 @entity0 non adhering to gluten free diet (GFD), adhering to GFD and among healthy subjects. RESULTS: Mean titre of anti alpha enolase antibodies was higher in @entity5 @entity0 (both treated and non treated) in comparison to control group, respectively 1.1 ng/mL, and 0.795 ngl mL. Among @entity5 @entity0 non adhering to gluten free diet mean titre was 1.4 ng/mL. CONCLUSIONS: Higher anti alpha enolase antibodies titres in non treated @entity5 suggest usefulness of its measurement. These antibodies might be a novel marker of @entity1 among @entity5 @entity0 non adhering to GFD.

title: [Antibodies against alfa-enolase as an indication of inflammatory process in XXXX with celiac disease--preliminary results].

answer: @entity0


abstract: BACKGROUND: Repair of a @entity3 is a challenging procedure and, to date, there is no consensus as to which technique should be used because of the specific complications reported for each. PURPOSE: A new endoscopic technique is described that uses a suture anchor to repair distal biceps tendon @entity3 . STUDY DESIGN: Case series; Level of evidence, 4. METHODS: The results of a cohort of 23 @entity0 (25 elbows) are reported with a median follow-up of 26 months. All @entity0 were male and their median age was 44 years (range, 30-58). Ten of the @entity0 (12 @entity3 ) were professional athletes or had a high level of physical activity. All repairs were performed via a 3-cm incision made in the "safe area" of the anterior crease of the forearm. The whole procedure was performed within the @entity5 . The tendon was reinserted using a single anchor. RESULTS: Of the 23 @entity0 , 22 were satisfied and 20 @entity0 returned to their preinjury sports and jobs. There was a mean loss of 8.6 degrees of pronation and 5 degrees of supination. A single severe @entity2 , which required a second surgical procedure, was reported. There were also 2 ectopic ossifications without clinical consequences and a transitory radial nerve @entity4 . CONCLUSIONS: This study clearly demonstrated that endoscopic repair of the @entity3 is safe, effective, and reproducible. It provides good functional outcome and early recovery with few complications. Postoperative @entity6 due to @entity1 is a possible concern for @entity0 involved in athletic activity and with a history of nerve entrapment; thus this technique should be used with caution in this group of @entity0 .

title: Repair of XXXX using a suture anchor: description of a new endoscopic procedure.

answer: @entity3


abstract: BACKGROUND: RESULTS from previous studies concerning the association of @entity4 @entity5 polymorphism with risk of @entity1 were inconsistent. To explore the exact relation with susceptibility, we conducted the present meta-analysis. MATERIALS AND METHODS: Literature of electronic databases including PubMed, Web of Science, EMBASE, Wanfang and Chinese National Knowledge Infrastructure (CNKI) were systematically searched. ORs and their 95%CIs were used to assess the strength of associations between @entity4 polymorphism and @entity1 risk. RESULTS: There was no significant association between @entity4 @entity5 AA or AG genotypes and overall risk of @entity1 (AA vs. GG: OR=0.998, 95%CI=0.670-1.486, P=0.992; AG vs. GG: OR=0.970, 95%CI=0.888- 1.061, P=0.508). A dominant genetic model also did not demonstrate significant association of (AA+AG) genotype carriers with altered risk of @entity1 (OR=0.985, 95%CI=0.909-1.068, P=0.719). In addition, no significant association was observed between A allele of @entity4 @entity5 @entity3 polymorphism and altered @entity1 risk compared with G allele (OR=0.952, 95%CI=0.851-1.063, P=0.381). Subgroup analysis suggested that AA genotype carriers were significantly associated with decreased risk of @entity2 compared with wild-type GG genotype individuals (OR=0.523, 95%CI=0.275-0.993, P=0.048). For subgroup of @entity0 , A allele of @entity4 @entity5 @entity3 polymorphism was significantly associated with decreased risk of @entity0 compared with G allele (OR=0.806, 95%CI=0.697-0.931, P=0.003). CONCLUSIONS: This meta-analysis indicated that @entity4 @entity5 @entity3 polymorphism might not be associated with risk of @entity1 . However, individuals with the AA genotype were associated with significantly reduced risk of @entity2 compared with wild-type GG genotype; The A allele was associated with significantly reduced risk of @entity0 compared with G allele. Future large- scale studies performed in multiple populations are warranted to confirm our results.

title: Associations of @entity4 XXXX Polymorphism with Cancer Risk: an Updated Meta-analysis.

answer: @entity5


abstract: The assessment of @entity1 angiogenesis in @entity4 is presently a subject of intensive research with potential clinical applications. In this study, the expression of @entity2 and @entity3 was examined by immunohistochemistry in 67 @entity1 samples obtained from @entity4 @entity0 treated by radical resection. Distribution of age, sex, @entity1 stage and histology was typical for @entity0 population in Poland. @entity2 expression (more than 25% of positive cells) was noted in 65% of @entity1 cells. @entity3 expression was observed in 91% of @entity1 cells. Neither the number of positive cells nor the staining intensity correlated with the clinical variables (all p values >0.05, chi-square test). No correlation was noted between the expression of @entity2 and @entity3 (p=0.35, chi-square test). In survival analysis, neither the number of positive cells nor the staining intensity of both molecules was of prognostic significance. The expression of @entity2 and @entity3 in @entity4 cells was confirmed in this study. The relation to clinical variables and survival will be further assessed in a larger group of @entity0 .

title: Expression of @entity2 ( @entity2 ) and its receptor @entity3 in XXXX ( @entity4 )--a preliminary report.

answer: @entity4


abstract: UNASSIGNED: Despite the routine collection of oocytes from @entity5 ( @entity5 ) for use in research, few studies have evaluated methods for preparing their skin for surgery. We evaluated 3 skin preparatory agents by examining their antibacterial efficacy and the gross and microscopic appearance of @entity5 skin after exposure. Frogs (n = 14) were sedated and treated (contact time, 10 min) with 0.9% sterile @entity7 on one-half of the ventrum and with 0.5% @entity8 or 0.75% @entity4 on the other half. Bacterial cultures were obtained before and after skin treatment; bacteria were identified by mass spectrometry. To assess @entity0 and degenerative changes, the incision sites were photographed and biopsied at 0, 1, and 7 d after surgery. We isolated at least 22 genera of bacteria from the skin of our frog population (mean    SE, 5.21    0.82 genera per frog). @entity6 (2.00    0.44 genera) and @entity4 (0.29    0.76 genera) both had greater antimicrobial activity than did saline. Skin erythema did not correlate with treatment group. Histologic evidence of @entity3 and @entity1 was greater on days 1 and 7 after @entity4 treatment than after @entity6 or saline. In addition, frogs treated with @entity4 had a higher incidence of clinical illness associated with the exposure site. In summary, although @entity4 has adequate antimicrobial activity against organisms on @entity5 skin, it leads to @entity2 and subsequent clinical complications. We therefore do not recommend @entity4 as a preoperative preparation agent in @entity5 .

title: Evaluation of Presurgical Skin Preparation Agents in @entity5 ( XXXX ).

answer: @entity5


abstract: OBJECTIVE: Development of new custom-made devices to reconstruct alveolar bone for implantation, and comparison with conventional methods were the goals of this study. MATERIALS AND METHODS: Using a computer-aided design technique, three-dimensional images were constructed. From these data, custom-made devices were produced by a selective laser melting method with pure @entity3 . Clinical trials also have been conducted with 26 @entity0 who needed bone reconstruction before implantation; they were divided into 2 groups with 13 @entity0 each. The first group uses custom-made devices; the other uses commercial @entity3 meshes that need to bend during operation. Some clinical aspects are evaluated after the trial. RESULTS: The custom-made devices can be produced closely by following the data precisely. Devices are fit for bone defect site. Moreover, the operation time of the custom-made group (75.4      11.6  min) was significantly shorter than that of the conventional group (111.9      17.8  min) (p  <  0.01). @entity1 occurs, without significant difference (p  =  0.27), in a @entity0 in the custom-made without severe @entity2 (7.7%), and 3 in conventional (23.1%), respectively. The retaining screw is significantly fewer in the custom-made group than commercial mesh group (p  <  0.01). CONCLUSION: These results indicate that our novel protocol could be simple and safe for providing powerful support for guided bone regeneration.

title: Custom-made XXXX devices as membranes for bone augmentation in implant treatment: Clinical application and the comparison with conventional @entity3 mesh.

answer: @entity3


abstract: BACKGROUND: @entity4 @entity4 antimicrobial resistance is the most common reason for eradication failure. Small studies have shown @entity3 resistance to be more prevalent in certain population groups. AIM: To determine the resistance rates in a large cohort of @entity0 from a single centre in the UK, and to evaluate resistance patterns over time, according to age, sex and socio-economic status. METHODS: Consecutive @entity0 with @entity4 -positive antral gastric biopsy samples were studied from 1994 to 1999. Susceptibility testing was performed to @entity3 , @entity2 , @entity5 and @entity1 by the modified disk diffusion METHOD: The Jarman under-privileged area score was used as a measure of socio-economic status. RESULTS: A total of 1064 @entity0 were studied. Overall @entity3 resistance was 40.3%, decreasing with age (P < 0.0001, odds ratio for @entity0 over 60 years 0.63, 95% CI: 0.48-0.80). @entity0 were more likely to have @entity3 resistant strains (P=0.003, odds ratio 1.5, 95% CI: 1.15-1.91), but there was no association with Jarman score. @entity5 resistance was associated with @entity3 resistance (P=0.03, odds ratio 2.14, 95% CI: 1.07-4.28). CONCLUSIONS: @entity3 resistance in @entity4 is highly prevalent and more common in @entity0 and the young, but does not appear to be related to socio-economic status.

title: XXXX @entity4 antimicrobial resistance in the United Kingdom: the effect of age, sex and socio-economic status.

answer: @entity4


abstract: OBJECTIVE: To evaluate the long-term results of @entity0 surgically treated for metastatic @entity4 ( @entity4 ) with a unique pancreatic secondary localization to assess the importance of radical treatment in this rare group of @entity0 . @entity0 AND METHODS: This is a retrospective monocentric study including 20 surgically treated @entity0 between 1997 and 2012 for a unique pancreatic @entity1 of a @entity4 . The main objective was to evaluate the outcome after surgical resection. RESULTS: Twenty @entity0 were followed up for a @entity4 . The M/F ratio was 1.2. The average age of onset of @entity2 was 57.05    7.78  years. Two @entity0 who had synchronous pancreatic @entity1 and 18 @entity0 who had metachronous @entity1 appeared after an average of 130    59  months (24-240 months). The average size of the metastases was 20    11.6  mm. @entity3 was unique in all @entity0 , with 35% of @entity0 having multiple lesions of the pancreas. All @entity0 underwent a pancreatic resection of @entity1 . Histologic examination confirmed the location of a secondary @entity4 in all @entity0 . Median follow-up after pancreatectomy was 69  months (1-150 months). Disease-free survival at 2  years was 60%. Overall survival rates at 2 and 4  years were 79% and 72%, respectively. There was no difference found between @entity0 with multiple and unique pancreatic metastases in overall survival. CONCLUSION: Unique pancreatic @entity1 of @entity4 is rare. The literature on this subject is limited. Surgical resection might be an option and can be associated with long-term disease-free intervals in highly selected @entity0 .

title: XXXX from @entity4 : outcome of an aggressive approach.

answer: @entity3


abstract: Non @entity4 antagonist oral anticoagulants (NOACs) have advantages relative to traditional @entity4 antagonist oral anticoagulants and represents an important advance in the management of @entity0 with @entity1 and @entity3 . Yet it is unclear whether the clinical trials evaluating these agents were inclusive of diverse populations. To assess the inclusion and reporting of race and ethnicity in clinical trials of NOACs across disease states including, @entity1 , @entity3 , and @entity2 , we queried PubMed and ClinicalTrials.gov for trials of NOACs between 2007 and 2013. We determined the reporting rate and inclusion of the following ethnic groups: whites, blacks, Asians, and Hispanics. We reviewed data from 30 randomized clinical trials of NOACs that enrolled 184,414 @entity0 . Among these trials, 21 (70  %) reported race/ethnicity data in the primary manuscript or on ClinicalTrials.gov. Principal investigators provided race/ethnicity data for two additional trials. Enrollment by race included: 109,729 (75.2  %) white, 20,901 (14.3  %) Asian, 5,718 (3.9  %) Hispanic, and 2,941 (2.0  %) black. Hispanic ethnicity was only reported in 10 trials. The major clinical trials of NOACs inconsistently reported race/ethnicity and overall black and Hispanic @entity0 enrollment was poor. As such, the relative safety and efficacy of NOACs in minority populations remains uncertain.

title: Review of race/ethnicity in non XXXX antagonist oral anticoagulants clinical trials.

answer: @entity4


abstract: 1. The antagonism at alpha-adrenoceptors by @entity3 and @entity2 of the response to @entity1 was investigated in the limb veins and arteries of @entity0 .2. Brachial artery infusions of @entity3 (40 mug/min) produced rises in resting arterial flow of up to 100%. When infused mixed with @entity1 , @entity3 (40 mug/min) attenuated the blood flow response to @entity1 . Blockade was of a similar degree to that which occurred following a 10 min infusion of @entity2 (40 mug/min).3. Local intravenous infusion of @entity3 (400-2,000 ng/min) mixed with @entity1 attenuated the venoconstrictor response to @entity1 . The degree of attenuation was similar to that seen after a 10 min infusion of @entity2 (500 ng/min). Blockade after @entity3 did not last longer than 16 minutes. Neither @entity3 nor @entity2 altered resting venous compliance.4. Local intravenous infusions of @entity3 (500 ng/min) and @entity2 (500 ng/min) abolished the sympathetically mediated venoconstriction produced by overbreathing.5. Systemic injection of @entity3 (0.1 mg/kg) did not block the reduction in forearm arterial flow produced by locally infused @entity1 . In two out of three experiments, however, it produced some antagonism of @entity1 induced venoconstriction. Systemic @entity2 (5 mg) blocked the effect of @entity1 in the arterial bed, but antagonized its actions in the veins in only one out of three experiments.

title: Comparison of blockade at alpha-adrenoceptors by @entity3 and @entity2 in peripheral arteries and veins of XXXX .

answer: @entity0


abstract: @entity0 growth is associated with @entity7 , @entity4 , and extramedullar hematopoiesis. The mechanism(s) accounting for these phenomena is unclear, although @entity5 ( @entity5 ) and/or @entity10 ( @entity10 ) released by @entity0 cells have been involved. We studied whether CSF released by @entity8 ( @entity8 ) may play a role. A comparative study was performed with two cell variants ( @entity8 and @entity8 /0) growing in euthymic, nude, and @entity3 @entity1 . Extramedullar hematopoiesis was assessed in the spleen by scoring organ enlargement, @entity6 germ agglutinin ve+ cells, and interleukin 3-dependent granulocyte-macrophage colony-forming unit (GM-CFU). Both cell lines showed the same cytokine profile by reverse transcriptase polymerase chain reaction, including @entity5 , @entity10 , and @entity9 ( @entity9 ); yet, only @entity8 cells produced detectable colony-stimulating activity in vitro, mainly due to @entity5 . No differences in tumorigenicity were noted between @entity8 and @entity8 /0 cells inoculated to normal or @entity2 @entity1 . An increase in extramedullar hematopoiesis, accompanied by @entity7 and @entity4 , was associated with @entity0 progression irrespective of the cell line. A strong correlation was obtained between the increase in splenic GM-CFU and @entity0 mass (r = 0.96, p < 0.0001) that was independent on the @entity0 cell line, strain of @entity1 , or stage of @entity0 development. The results point against CSF released by @entity0 cells and/or reactive host T cells as the only factors involved in the extramedullar hematopoiesis in this @entity0 model. The remarkable correlation between @entity0 mass still suggests that a factor(s) of @entity0 origin may play a critical role.

title: XXXX stimulates extramedullar hematopoiesis in @entity1 without secreting identifiable colony-stimulating factors and without engagement of host T cells.

answer: @entity8


abstract: OBJECTIVE: Very few studies have examined post-operative morbidity after resection of @entity3 , especially in @entity0 treated with induction chemo- and radiotherapy for locally advanced stages. This study assessed the effects of induction chemoradiotherapy on post-operative course after resection of locally advanced @entity3 ( @entity15 + cM1lymph). METHODS: Induction therapy consisted of @entity14 days 1-5 and days 21-25, @entity11 day 1 + day 21 and concomitant radiotherapy 18-20 fractions of 2Gy (total dose 36-40Gy). Induction chemoradiotherapy was completed in 109 @entity0 . Surgery was performed in 90 @entity0 (operability: 90/109 = 83%): 85 @entity0 underwent resection with curative intent (resectability: 85/109 = 78%), bypass operation was performed in five @entity0 . Nineteen @entity0 could not be operated on. Results were compared to a matched group of pT3M1LYM/pT4 @entity0 (n = 86) who underwent primary surgery in the same period. RESULTS: Resection was complete (R0) in 68 @entity0 (68/90 = 76%). Mean duration of surgery was 428 min (range: 240-690). Peroperative complications were @entity6 in three @entity0 (3/90 = 3.3%), tracheobronchial perforation in three @entity0 (3/90 = 3.3%). Median total hospital stay was 20.5 days (range: 8-355). Mean duration of intubation was 7 days (range: 1-190); 67 @entity0 (67/90 = 74.4%) were intubated for less than 24 h. @entity1 related hospital mortality after resection was 8.3% (7/84 @entity0 ). Mortality after two-field lymphadenectomy was 5.2 versus 11.7% after three-field lymphadenectomy. After primary surgery (n = 86) overall mortality was 2.3% (P = 0.015) and nil after two- and three-field lymphadenectomy (P = 0.011). Medical morbidity consisted of @entity2 in 43 @entity0 (43/90 = 48%), @entity10 in ten @entity0 (10/90 = 11%), @entity12 in 21 @entity0 (21/90 = 23%), @entity5 in 11 @entity0 (11/90 = 12%) and adult @entity7 in ten @entity0 (10/90 = 11%). Surgical morbidity included @entity13 in 16 @entity0 (16/90 = 18%), @entity4 in two @entity0 (2/90 = 2%), chylothorax in two @entity0 (2/90 = 2%) and acute @entity8 in one @entity0 (1/90 = 1%). Ten @entity0 (10/90 = 11%) had a radiologically confirmed @entity9 ; however only in four out of them with clinical manifestation; treatment was conservative in all four @entity0 . Major morbidity occurred in 27 @entity0 (27/90 = 30%). Overall rate of morbidity was significantly higher after three-field lymphadenectomy (85%) as compared to two-field lymphadenectomy (68.7%; P = 0.023). CONCLUSIONS: Chemoradiotherapy followed by resection of @entity15 +/- cM1lymph @entity3 is feasible with acceptable mortality. Mortality, however, seems to be significantly higher when compared to a group of pT3M1LYM/pT4 @entity0 who underwent primary surgery (8.3 versus 2.3%; P = 0.015) in the same period in our department.

title: Effects of preoperative chemoradiotherapy on postsurgical morbidity and mortality in XXXX +/- cM1lymph cancer of the oesophagus and gastro-oesophageal junction.

answer: @entity15


abstract: Hypericum perforatum L. (St. John's wort) is a medicinal plant used for many pathologies, especially for the treatment of mild to moderate @entity3 . In the present study we have investigated the cytotoxic activity of the locally collected (Epirus region) Hypericum perforatum L. against cultured @entity0 and @entity2 cell lines. The lipophilic extract of the herb, prepared using @entity4 , induced apoptosis displaying LC(50) values at concentrations as low as 4 and 5 microg/mL. A fraction of this extract displayed 60 % cell growth inhibition at a concentration of 0.95 microg/mL. Evaluating the importance of various biologically active components of the extract, it was found that hypericins ( @entity5 , @entity7 , etc.) were identified only in the methanolic (lipophobic) extract of the herb, and not in the active lipophilic extract. In addition, @entity6 concentrations in the lipophilic extract and its most active fraction, were 0.94 microg/mL, and 0.17 microg/mL, respectively, while the active cytotoxic concentration of pure hyperforin appeared in the range of 1.8 microg/mL - 5.0 microg/mL. Therefore, pure hyperforin does not seem to contribute significantly to the @entity1 activity. Chlorophylls were identified in low, not significantly different, concentrations in all extracts and fractions and were not correlated to the biological activity. Owing to the combination of significant cytotoxic activity, natural abundance and low @entity1 , the lipophilic extract of Hypericum perforatum holds the promise of being an interesting, new, antiproliferative agent against @entity2 that deserves further investigation.

title: The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against @entity0 and NBT-II XXXX cells.

answer: @entity2


abstract: This study was conducted in order to investigate the implications of the @entity4 polymorphism in the @entity2 gene in @entity0 risk. The enlightenment of this matter might provide a piece of information about the potential implications of this polymorphism in @entity1 risk. A meta-analysis was conducted considering a large sample size from studies with conflicting results on the @entity4 polymorphism in @entity0 @entity1 . Relevant studies were selected from PubMed and SciELO databases for data extraction and statistical analysis. Database was built according to the continent and considering the genotype frequencies, sample size and genotyping methodology. The dominant models (RR vs @entity3 + PP and RR + @entity3 vs. PP), homozygous (RR vs. PP), heterozygous (RR vs. @entity3 and @entity3 vs. PP) and the allele (R vs. P) were used. Genotype frequencies were summarized and evaluated by   (2) test of heterogeneity in 2*2 contingency tables with 95% CIs. Odds Ratios (OR) were calculated with a fixed-effect model (Mantel-Haenszel) or a random-effect model (DerSimonian-Laird) if the studies were considered homogeneous (P > 0.05) or heterogeneous (P < 0.05), respectively, using BioEstat   5.0 software. Supported by a large sample size composed by 25,629 cases and 26,633 controls from 41 studies, we found significant association between the @entity4 polymorphism in the @entity2 gene and the @entity0 risk. The overall data shows an increased risk due to the P allele dominant model, but not in Asia where the risk was associated with the R allele and R dominant model.

title: Association of the XXXX codon 72 polymorphism and @entity0 risk: a meta-analysis.

answer: @entity2


abstract: BACKGROUND: National registries are advocated as instrumental to the solution of rarity-related problems for @entity0 with @entity5 ( @entity5 ), including limited access to advanced treatment options. Thus, an Italian Registry for @entity5 was created to assess the clinical profile and the level of care nationwide of @entity0 with @entity5 . METHODS: Cardiology centers over the national territory were recruited to provide clinical data of all @entity0 with @entity5 ever seen at each institution. The enrollment period was from May 2000 to May 2002. RESULTS: The registry enrolled 1677 @entity0 from 40 institutions. Most (69%) were followed at referral centers, whereas 31% were from community centers with intermediate-low @entity0 flow. @entity0 diagnosed after routine medical examinations or familial screenings were 39%. Most @entity0 were male (62%), in their fourth to sixth decade of life, and in New York Heart Association class I to II (89%); 24% had resting left @entity1 and 18% had @entity4 . During a 9.7-year average follow-up, cardiovascular mortality was 1%/y, mostly because of @entity2 , with no significant change over the last 3 decades; @entity3 was less common (0.4%/y). Only 4% of @entity0 received a defibrillator; 14% of the 401 @entity0 with LV outflow obstruction underwent invasive relief of obstruction; and <1% were offered genetic analyses or counseling. CONCLUSIONS: The Italian Registry represents the first comprehensive attempt to evaluate the clinical impact and management of @entity5 at a national level. Findings underscore the role of screening strategies for an early diagnosis and suggest limited use of the advanced therapeutic options for @entity5 .

title: The Italian Registry for XXXX : a nationwide survey.

answer: @entity5


abstract: OBJECTIVE: Phyllodes @entity2 of the breast is a rare @entity0 that comprise 0.3-0.9% of primary @entity0 . In this study, we aimed to present clinicopathologic symptoms of our @entity1 along with their treatment modality. MATERIAL AND METHODS: Clinicopathologic properties and treatment modality of 20 phyllodes @entity2 @entity1 who underwent surgery between January 2008 and January 2013 were retrospectively evaluated. RESULTS: Median @entity1 age was 47 years (22-75). Fine-needle aspiration biopsy was applied to 19 @entity1 . Biopsy results were reported as suspicious in four, malignant in three, benign in 11, and as non-diagnostic in one @entity1 . Final histopathology reports revealed two benign, one malignant and one borderline @entity2 out of the four @entity1 with suspicious findings on fine needle aspiration biopsy; all @entity1 with malignant cytology had @entity2 . There were two borderline and nine benign lesions within the benign biopsy group. Sixteen @entity1 underwent segmental mastectomy, four @entity1 underwent mastectomy with/without axillary dissection. The median @entity2 size was 6 (1-13) cm. Histopathologically, 11 (55%) @entity2 were benign, 5 (25%) were borderline, and 4 (20%) were malignant. Two of the four @entity1 with @entity2 underwent radiotherapy and chemotherapy, and one @entity1 only received chemotherapy as adjuvant treatment. CONCLUSION: @entity2 are rare, mix-type @entity0 . Due to high rates of local recurrence and potential for @entity2 , preoperative diagnosis and accurate management are important.

title: How to approach phyllodes XXXX of the breast?

answer: @entity2


abstract: OBJECTIVE: The study of personality pathology in adolescence is in its infancy. This article examined the applicability and limits of DSM-IV @entity2 diagnoses in adolescents, assessed the validity of a method for assessing adolescent personality pathology, and began to develop an empirically grounded classification. METHOD: A total of 296 randomly selected clinicians described a @entity0 age 14-18 in treatment for @entity2 patterns using @entity3 II ratings scales and the Shedler-Westen Assessment Procedure-200 for Adolescents (SWAP-200-A), a Q-sort instrument for assessing adolescent personality pathology. After examining the nature and frequency of @entity1 in the sample, the authors used Q-factor analysis to identify naturally occurring groupings of @entity0 on the basis of shared personality features. RESULTS: Axis II diagnoses in adolescents resembled those in adults, although application of DSM-IV criteria appeared to overdiagnose antisocial and @entity2 in adolescents. Q analysis with the SWAP-200-A isolated five @entity2 (antisocial- @entity4 , emotionally dysregulated, avoidant-constricted, narcissistic, and histrionic) and one personality style. @entity0 ' dimensional scores on each diagnostic prototype showed predictable associations with ratings of current @entity1 , measures of adaptive functioning, and symptoms assessed with the @entity0 Behavior Checklist. CONCLUSIONS: With some exceptions, personality pathology in adolescence resembles that in adults and is diagnosable in adolescents ages 14-18. Categories and criteria developed for adults may not be the optimal way of diagnosing adolescents. Data from samples of adolescents may prove useful in developing an empirically and clinically grounded classification of personality pathology in adolescents.

title: Personality diagnoses in adolescence: DSM-IV XXXX II diagnoses and an empirically derived alternative.

answer: @entity3


abstract: INTRODUCTION: The main objective of the study was to determine the frequency of @entity0 receiving inappropriate empiric antibiotic therapy and to assess the impact in terms of increase length of hospital stay, 30-day re-admissions, and 30-day mortality. METHODS: An observational retrospective cohort study was conducted over a one-month period that included all @entity0 hospitalised from an @entity3 ( @entity3 ) due to @entity1 . Demographic variables, comorbidity, multi-resistance risk factors, site of @entity1 , microbiological findings, and antibiotic prescribed in @entity3 were collected. Outcomes were length of hospital stay, 30-day re-admissions, and 30-day mortality. RESULTS: A total of 376 @entity0 were included, with a mean age of 71.1 (SD 21) years. The most frequent causes were respiratory (45.7%) and urine (23.9%) infections. The number of @entity0 with length of stay over the median (>= 9 days) was 165 (46.1%), with re-admissions 74 (19.7%), and mortality at 30 days 44 (11.7%). There was inappropriate antibiotic treatment in 42 (11.2%) cases. After adjusting for demographic data, comorbidity, risk factors for multidrug resistant organism, presence of @entity2 criteria in @entity3 , and site of @entity1 , inappropriate treatment was associated with an extended length of hospital stay (OR 2.22; 95% CI; 1.07-4.60; P=.032), but did not to an increase in mortality (P=.271) or re-admission (P=.784) at 30 days. CONCLUSION: The inappropriate empirical antibiotic therapy in @entity0 admitted from the @entity3 leads to an extended hospital stay, but did not increase mortality or readmission.

title: [Effect of the inadequacy of antibiotic therapy in the XXXX on hospital stays].

answer: @entity3


abstract: When a @entity1 complication occurs during therapy with heparin or @entity3 antagonists, there is an option to give a specific antidote. Several new anticoagulants have been developed that are likely to have some risk of @entity1 complications, for which no specific antidotes are available. Interestingly, it is unknown how often the use of an antidote is necessary in clinical practice. We investigated 1877 @entity0 treated for @entity2 included in three large clinical trials, of which 181 (9.6%) had a total of 225 adjudicated @entity1 episodes; 46 @entity1 being designated as major. Some form of antidote was given to 26 (14.4%) @entity0 with a @entity1 . Of the @entity0 with at least one major @entity1 , 19 (41.3%) received an antidote. @entity3 was given to 23 (1.2%) @entity0 , one (0.05%) @entity0 received protamin sulfate and seven (0.4%) @entity0 received fresh frozen plasma. The use of antidotes was comparable for initial and long-term treatment. Antidotes were statistically significantly more frequently given in Canada as compared to other participating countries. @entity3 was more frequently given in case of a higher international normalized ratio value. Although antidotes against anticoagulant treatment are widely available, our analysis shows that in only a very small number of @entity0 a direct, or slow-acting antidote to reverse the anticoagulant effect was used.

title: The use of specific antidotes as a response to @entity1 complications during anticoagulant therapy for XXXX .

answer: @entity2


abstract: The growth behaviour of the probiotic strain @entity1 . toyoi in the gastrointestinal tract of broiler @entity0 and suckling piglets was evaluated. The strain germinated rapidly in intestinal samples from both animal species. Less than 10% of spores were recovered from the @entity0 crop and piglet stomach, respectively. Lumen samples and mucosal tissues from the hind gut of piglets displayed increasing colonization of the probiotic strain throughout the trial period. After oral administration of vegetative cells to broiler @entity0 and weaned piglets, sporulation was detected in all intestinal samples. The distribution of spore CFU indicated repeated germination and sporulation during the intestinal passage in piglets. @entity1 . toyoi was not able to colonize the intestinal tract of both animal species. However, the probiotic strain was detected in suckling piglets before uptake of @entity1 . toyoi supplemented feed. It is concluded that @entity1 . toyoi germinates rapidly in broiler @entity0 and piglets, which is a necessary prerequisite for its possible probiotic effects. Germination and in vivo sporulation of vegetative cells indicated that the probiotic strain was metabolically active in the intestine of both animal species.

title: Growth behaviour of a spore forming probiotic strain in the gastrointestinal tract of broiler XXXX and piglets.

answer: @entity0


abstract: An 163-bp fragment of the @entity1 cytochrome P450 gene, @entity6 has been shown to contain sequences that mediate @entity2 (PB) responsiveness of this gene. In studies on this @entity1 gene and the orthologous @entity0 gene, @entity5 , the minimal fragment required for near full PB responsiveness has varied from about 50 to 80 bp depending on the gene used and the number of copies of the PB responsive sequences assessed. Since there is a single copy of the CYP genes in the genome, we have evaluated deletion and block mutations across an 84-bp region of the PB responsive unit (PBRU), by in situ transfection in @entity1 liver using single copies of the PBRU sequences. From the 5' end, deletions to -2243 retained more than 50% responsiveness to PB compared to the 163-bp fragment. The fragment -2237 to -2155 retained less than 20% responsiveness even though it contained the nuclear receptor (NR)-1, NR-2, and NF-1 motifs which are present in the core of the PBRU. From the 3' end, deletions from -2170 to -2194 eliminated PB responsiveness indicating that the 74-bp sequence from -2243 to -2170 is able to mediate full PB responsiveness. Block mutations within the @entity4 and NF-1 regions reduced responsiveness most dramatically, but did not abolish it, and mutations 3' of the NF-1 site modestly reduced responsiveness. Protein binding was not affected by mutations in the @entity4 region as assessed by @entity3 footprinting in vitro but mutations within the NR-2 region reduced binding to the NF-1 site. Mutations of the 5' half or the 3' half of the bipartite NF-1 site, resulted in loss of protection of the NF-1 site and new footprints to the 3' or 5' side, respectively, of the NF-1 site. These results indicate that sequences in addition to the @entity4 and the NF-1 sites are required for full responsiveness to PB and suggest that proteins which bind to these sites may interact.

title: Functional analysis of the @entity2 -responsive unit in @entity1 XXXX .

answer: @entity6


abstract: UNASSIGNED: @entity2 (HA)-coated @entity4 nanoparticles (MNPs) are being widely investigated for various applications in medical engineering and wastewater treatment. In this work, the MNPs were thoroughly coated by bacterial synthesized HA nanoparticles during biomineralization process using @entity5 . The resulting bacterial-induced precipitate was then calcined at 600  C and investigated with respect to structural characteristics, particle size and magnetic strength by XRD, FT-IR, SEM, @entity6 , TEM and VSM analyses. The effects of MNPs and HA-coated MNPs (HA-MNPs) on the viability of @entity0 MCF-7 cell lines were also investigated via mitochondrial activity test (MTT) and @entity3 dehydrogenase (LDH) assays. The powder characterization results showed appropriate structural properties for HA-MNPs samples. The particles diameter size of the MNPs and HA-MNPs were in the range of 3-25nm and 20-80nm, respectively. The biologically-synthesized HA-MNPs formed a stable suspension in water while keeping their magnetic property. The saturation magnetization (Ms) of HA-MNPs was measured at ~10emug(-1) which was in good agreement with the structural composition of this sample. Finally, the results of the cell lines viability indicated that coating of toxic MNPs via biomineralization was a promising approach in order to synthesize bio-compatible magnetic nanoparticles with suitable physical and chemical structural characteristics. The @entity1 level of MNPs was reduced by 10 fold when coated by bacterial-synthesized HA.

title: A biological method for in-situ synthesis of @entity2 -coated @entity4 nanoparticles using @entity5 : Characterization and acute XXXX assessments.

answer: @entity1


abstract: UNASSIGNED: High grade serous @entity4 (HGSC) is a DNA instable @entity1 and its precursor is commonly found originating from the fimbriated end of the @entity9 ( @entity9 ) cells. The local stresses via ovulation and related @entity3 are risks for HGSC. In this study, we examined the cellular and molecular responses of @entity9 cells to stress. We found that excess intracellular reactive @entity2 species (ROS) in normal @entity9 cells upregulated a subset of microRNA expression (defined as ROSmiRs). Most ROSmiRs' expression and function were influenced and regulated by @entity5 , and together they drove the cells into @entity6 ( @entity6 ). However, ROS-induced @entity10 is regulated by @entity8 , not by @entity5 . In normal @entity9 cells, @entity10 overexpression triggers cellular senescence by @entity5 -mediated upregulation of @entity7 . Conversely, in cells with @entity5 mutations, @entity10 overexpression no longer enhances @entity7 but functions as an "Onco-miR". @entity5 dysfunction is a prerequisite for @entity10 -mediated tumorigenesis. In addition, we found that @entity0 follicular fluid could significantly induce intracellular ROS in normal @entity9 cells. These findings suggest that ROS and @entity5 mutations may trigger a series of events, beginning with overexpressing @entity10 by ROS and @entity8 , impairing the DNA damage response, promoting DNA instability, bypassing senescence and eventually leading to DNA instable @entity1 in @entity9 cells.

title: Role of @entity10 in response to oxidative stress in the cell fate of XXXX fallopian tube epithelial cells.

answer: @entity0


abstract: OBJECTIVE: To develop criteria for the classification of @entity3 ( @entity3 ) in @entity0 with @entity2 ( @entity2 ). METHODS: A multistep process, based on a combination of expert consensus and analysis of real @entity0 data, was conducted. A panel of 28 experts was first asked to classify 428 @entity0 profiles as having or not having @entity3 , based on clinical and laboratory features at the time of disease onset. The 428 profiles comprised 161 @entity0 with systemic @entity2 -associated @entity3 and 267 @entity0 with a condition that could potentially be confused with @entity3 (active systemic @entity2 without evidence of @entity3 , or @entity1 ). Next, the ability of candidate criteria to classify individual @entity0 as having @entity3 or not having @entity3 was assessed by evaluating the agreement between the classification yielded using the criteria and the consensus classification of the experts. The final criteria were selected in a consensus conference. RESULTS: Experts achieved consensus on the classification of 391 of the 428 @entity0 profiles (91.4%). A total of 982 candidate criteria were tested statistically. The 37 best-performing criteria and 8 criteria obtained from the literature were evaluated at the consensus conference. During the conference, 82% consensus among experts was reached on the final @entity3 classification criteria. In validation analyses, these criteria had a sensitivity of 0.73 and a specificity of 0.99. Agreement between the classification ( @entity3 or not @entity3 ) obtained using the criteria and the original diagnosis made by the treating physician was high (k   =   0.76). CONCLUSION: We have developed a set of classification criteria for @entity3 complicating systemic @entity2 and provided preliminary evidence of its validity. Use of these criteria will potentially improve understanding of @entity3 in systemic @entity2 and enhance efforts to discover effective therapies, by ensuring appropriate @entity0 enrollment in studies.

title: 2016 Classification Criteria for Macrophage Activation Syndrome Complicating XXXX : A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

answer: @entity2


abstract: UNASSIGNED: 7132 Background: We hypothesized that @entity10 improves the response and @entity2 profile of chemotherapy with @entity11 and @entity9 because of its novel mechanism of action (anti-angiogenic, anti-neoplastic, anti-inflammatory) which is different from classic chemotherapy and because it causes @entity5 which may counteract @entity3 of @entity9 . METHODS: Treatment consists of @entity11 AUC = 5 iv over 30 min day 1 and @entity9 50 mg/m(2) iv over 90 min day 1 and 8 q 21 days. @entity10 is given continuously po qhs starting on day 1 until progressive disease; the starting dose is 200 mg/d which is escalated by 100 mg per week if tolerated (max. 1,000 mg/d). The objectives are to determine the response rate, time to progression, overall survival, and @entity2 profile. Key eligibility criteria: @entity6 stage IIIB ( @entity12 ) and IV; measurable disease; no prior chemotherapy; prior radiation only allowed for brain @entity1 , neurologically stable; performance status (PS) 0-1; adequate hematologic, hepatic and renal function. RESULTS: So far, 36 @entity0 have been entered, but 2 never received protocol treatment; characteristics of 34 treated @entity0 : median age 65 (47-79); female/male 8/26; black/white 2/32; PS 0/1 in 10/24; stage 3/4 in 6/28. 23 @entity0 are evaluable for response: partial 5 (22%), stable 12 (52%). The median time to progression is 3.6 months (95% CI, 2.3-4.9). 19 of 34 @entity0 have died. The median survival time is 7.3 months (95% CI, 3.4-14.2). Frequent @entity2 are @entity8 (grade 3/4 in 20%/8%), @entity7 /malaise (grade 3/4 in 16%/4%), and @entity4 /vomiting (grade 3/4 in 20%/0%). @entity3 grade 3/4 occurred in 4%/4%. No @entity0 had lethal @entity2 . CONCLUSIONS: Treatment with @entity11 , @entity9 , and @entity10 on this regimen is tolerable with reversible @entity8 as the major @entity2 . Accrual to this study continues to more firmly establish the objective response rate and survival time. *Supported by NCI grant U10CA81851-04 [Table: see text].

title: Phase II study of @entity11 , @entity9 , and XXXX in @entity0 with advanced @entity6 ( @entity6 ).

answer: @entity10


abstract: PURPOSE: To investigate the incidence of @entity3 induced by latanoprost ophthalmic solution in Japanese @entity1 @entity0 by a prospective and observer-masked study. @entity0 AND METHODS: Sixty-nine eyes of 69 @entity1 @entity0 were included. @entity0 who had undergone intraocular surgery, laser trabeculoplasty, and laser iridotomy within 12 months before enrollment, and @entity0 with history of @entity2 and any changes in antiglaucoma drugs within 6 months before enrollment were excluded. Iridial photographs were taken by one examiner under the same conditions at 1, 3, and 6 months after the initiation of latanoprost treatment. Three @entity1 specialists, masked of @entity0 information, independently assessed the @entity3 . Cases with @entity3 diagnosed by three specialists were categorized as showing a definite increase in @entity3 . RESULTS: A definite increase in @entity3 occurred in 3.5%, 9.7%, and 35.0% of eyes within 1, 3, and 6 months of treatment, respectively. Age, gender, or concomitantly used eyedrops did not significantly influence the incidence of @entity3 within 6 months of instillation. A reduction of intraocular pressure by latanoprost did not differ significantly between @entity0 with and without @entity3 . CONCLUSION: The incidence of @entity3 by latanoprost ophthalmic solution in Japanese @entity0 was higher than previously reported values in pigmented races.

title: Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese XXXX @entity0 .

answer: @entity1


abstract: Morgagni-Larrey's @entity3 , which are both infrequent and generally asymptomatic, are often diagnosed by chance during routine diagnostic tests performed for other pathologies. Usually congenital in adults, they are often small or only take the form of a @entity1 . @entity2 is rarely described and frequently entails diagnostic difficulties before hydroaerial levels are demonstrated in the thoracic region. In these cases, surgery using an abdominal approach should be preferred in order to treat compressed abdominal viscera at the same time and to exclude the bilateral nature of the lesion. The authors present two cases of an adult @entity0 and @entity0 who were referred to their attention for occlusive pathologies. Both were operated using a laparotomy approach. The reduction of abdominal viscera did not present any difficulties. The hernial sac was only removed in the first @entity0 . Plastic surgery was completed by attaching the diaphragmatic flap to the costal and sternal wall using separate non-reabsorbing suture stitches. No complications were reported.

title: [ XXXX caused by Morgagni-Larrey diaphragmatic hernia].

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is an innovative technique of pelvic dissection for low @entity1 . Our objective was to evaluate our pilot experience with this procedure compared with @entity3 ( @entity3 ). METHODS: We performed a retrospective 5-year review of all consecutive cases of @entity2 and @entity3 performed at our institute. We focused on @entity1 characteristics, quality of surgery, analgesic requirements, average length of hospital stay (LOS), complications and long-term outcomes. RESULTS: Three @entity0 underwent @entity2 and 25 had @entity3 . The average duration of surgery was similar (288 min for @entity2 v. 285 min for @entity3 ). Four @entity0 in the @entity3 group had positive or very close margins, and 2 had a mesorectal defect less than 5 mm. The average LOS was 6.66 and 9.29 days in the @entity2 and @entity3 groups, respectively, and the average duration of epidural or @entity0 -controlled anesthesia was 2.67 and 5.16 days, respectively. We did not perform a statistical comparison because of the discordant size and sex distribution between the groups. There were no perioperative complications in the @entity2 group, and all @entity0 had negative margins and adequate lymph node retrievals with no long-term complications or recurrence recorded so far. CONCLUSION: Our very early experience with @entity2 is quite encouraging, suggesting that it is a safe alternative to @entity3 with a similar duration and the added benefits of a minimally invasive procedure, including decreased LOS and reduced postoperative analgesic requirements.

title: Evaluation of pilot experience with robotic-assisted proctectomy and coloanal XXXX for @entity1 .

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVE: Reendothelization of damaged blood vessels protects against the @entity2 response. We evaluated in vivo whether a systemic increase in @entity1 accelerates reendothelization and attenuates intimal @entity3 in injured @entity4 carotid and coronary arteries. METHODS: Both carotid arteries of 10 @entity4 were subjected to @entity0 . Five animals had been treated with 2 ml (10 mg) of @entity5 , an activator of the adenylate cyclase, and another 5 with 2 ml of saline solution. These animals were sacrificed at day 8, and carotid artery reendothelization was evaluated. The descendent coronary (DC) artery of another 19 @entity4 was injured by atherotome. Nine animals had been treated with 2 ml of @entity5 , and another 10 with 2 ml of saline solution. These animals were sacrificed at day 28, with myointimal proliferation and arterial geometric remodelation being evaluated. Likewise, in these animals intracellular @entity1 levels were measured at baseline and 28 and 60 minutes after saline solution or @entity5 administration and 90 min after @entity2 . RESULTS: Eight days after @entity0 , carotid artery reendothelization was greater in the @entity5 -treated group compared with the control group (p = 0.02), and the number of @entity6 positive cells was statistically increased in the treated group (38 +/- 11 cells) versus controls (11 +/- 9 cells). Although the degree of @entity2 caused by atherotome was similar in all of the arteries in the control group, restenosis was only observed in 40% of these animals. Correlation analysis demonstrated that intracellular @entity1 may condition arterial geometric remodeling and the diameter of the lumen after @entity2 . CONCLUSION: Our results suggest that @entity1 may promote reendothelization and attenuate fibromuscular proliferation.

title: [Effect of XXXX on the function of endothelial cells and fibromuscular proliferation after the injury of the carotid and coronary arteries in a porcine model].

answer: @entity1


abstract: BACKGROUND: Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various solid @entity1 . This study aimed to evaluate the prognostic role of NLR in @entity0 with @entity2 ( @entity2 ). METHODS: A total of 141 @entity2 @entity0 were retrospectively reviewed. @entity0 ' demographics were analyzed along with clinical and pathologic data. The optimal cutoff value of NLR was determined using receiver operating characteristic (ROC) curve analysis. The impact of the NLR and other potential prognostic factors on disease-free survival (DFS) and @entity3 ( @entity3 ) was assessed using the Kaplan-Meier method and multivariate Cox regression analysis. RESULTS: The optimal cutoff value of the NLR was 2.17. In the NLR    <=   2.17 group, the 1-, 3-, and 5-year DFS rates were 88.2, 73.9 and 69.1  %, respectively, while in the NLR   >   2.17 group, the DFS rates were 83.0, 54.6 and 49.2  %, respectively. Correspondingly, the 1-, 3-, and 5-year @entity3 rates were 98.9, 85.1 and 77.4  % in the NLR    <=   2.17 group and 97.9, 63.8 and 53.3  % in the NLR   >   2.17 group, respectively. The multivariate Cox proportional hazard model analysis showed that NLR   >   2.17 was a prognostic factor for both DFS [hazard ratio (HR)   =   1.869; 95  % confidence interval (CI) 1.078-3.243; P   =   0.026] and @entity3 (HR =2.177; 95  % CI 1.208-3.924; P   =   0.010). CONCLUSION: Our results showed that elevated preoperative NLR was an independent predictor of poor prognosis for @entity0 with @entity2 after surgical resection.

title: Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in XXXX with @entity2 .

answer: @entity0


abstract: BACKGROUND: The Overall Nutritional Quality Index (ONQI) algorithm is a nutrient profiling scheme that incorporates more than 30 dietary components, and it aims to rank foods by relative healthfulness. PURPOSE: To assess whether diets with a higher ONQI score predict lower risk of major @entity4 risk. METHODS: A total of 62,284 healthy @entity0 from the Nurses' Health Study and 42,382 healthy @entity0 from Health Professionals Follow-Up Study were followed from 1986 to 2006. Dietary data were collected from questionnaires at baseline. Each food was scored by the ONQI algorithm and the average ONQI score for the diet consumed by each @entity0 was computed. @entity4 was defined as @entity3 ( @entity3 ); @entity1 ; @entity2 ; and nontrauma @entity5 . Data analysis was conducted in 2010. RESULTS: A total of 20,004 and 13,520 @entity4 events were documented in @entity0 and @entity0 , respectively. The ONQI score was inversely associated with risk of @entity4 , @entity3 , @entity2 , and all-cause mortality (p-trend <=0.01), but not @entity1 , in both cohorts. @entity0 in the highest compared to lowest quintile of the ONQI score had a relative risk (95% CI) of 0.91 (0.87, 0.95) for @entity4 ; 0.79 (0.71, 0.88) for @entity3 ; 0.86 (0.78, 0.96) for @entity2 ; and 0.90 (0.84, 0.97) for all-cause mortality. @entity0 in the highest compared to lowest quintile of the ONQI score had a relative risk of 0.88 (0.83, 0.93) for @entity4 ; 0.77 (0.70, 0.85) for @entity3 ; 0.84 (0.73, 0.96) for @entity2 ; and 0.89 (0.83, 0.97) for all-cause mortality. CONCLUSIONS: Consumption of foods that lead to a higher score for the ONQI scoring system is associated with modestly lower risk of @entity4 and all-cause mortality.

title: The association between a nutritional quality index and risk of XXXX .

answer: @entity4


abstract: OBJECTIVE: The aim was to evaluate the effect of a @entity3 -containing brush-on gel when used as supplement to oral hygiene instructions and mechanical debridement, on @entity1 in adults. MATERIALS AND METHODS: The study group consisted of 38 adults (48-87 years.) with @entity1 that were consecutively enrolled in three private clinics after informed consent. The study employed a double-blind controlled design with two parallel arms. After baseline registrations, oral hygiene reinforcement and mechanical debridement, the @entity0 were randomly allocated to either a test group with once daily tooth brushing with an oral care brush-on gel containing 0.2% @entity4 (Cervitec Gel) or a control gel group. The duration of the intervention was 12 weeks. The primary outcome was @entity2 on probing (BOP) and secondary endpoints were local plaque score (LPS) and @entity5 ( @entity5 ). RESULTS: The groups were balanced at baseline. The daily use of the @entity3 -containing gel resulted in reduced BOP after 4 and 12 weeks compared with the control group (P < 0.05). The @entity5 was significantly reduced (P < 0.05) after 12 weeks compared to baseline in the test group, but not in the control group. No side effects or adverse events were reported. CONCLUSION: The present findings indicated moderate but significant improvements of clinical parameters when mechanical debridement was combined with a self-applied oral care brush-on gel for the management of @entity1 .

title: Effect of a XXXX -containing brush-on gel on @entity1 .

answer: @entity3


abstract: OBJECTIVE: The strongest evidence for effectiveness of screening, brief intervention, and referral to treatment (SBIRT) programs is in primary care settings. @entity2 ( @entity2 ) studies have shown mixed results. Implementation of SBIRT into @entity2 settings is complicated by the type of @entity0 seen and the fast-paced, high-throughput nature of the @entity2 environment that makes it difficult to reach @entity0 flagged for SBIRT services. This study uses data from an @entity2 -based SBIRT program to examine the relationship between screen-positive rate, @entity2 @entity0 flow, and SBIRT service delivery. METHODS: Data for the study (N = 67137) were derived from weekly reports extracted directly from one hospital's electronic health record. Measures included time and day of @entity0 entry, drug/ @entity1 screen result (positive or negative), and whether the @entity0 was reached by SBIRT specialists. Factorial analysis of variance compared variations in screen-positive rates by day and time and the percentage of @entity0 reached by SBIRT specialists during these periods. RESULTS: Overall, 56% of screen-positive @entity0 received SBIRT services. Only 5% of @entity0 offered SBIRT services refused. Day and time of entry had a significant interaction effect on the reached rate (F12,14166 =3.48, P < .001). Although @entity0 volume was lowest between 11 pm and 7 am, screen-positive rates were highest during this period, particularly on weekends; and @entity0 were least likely to be reached during these periods. CONCLUSIONS: When implementing an @entity2 -based SBIRT program, thoughtful consideration should be given to @entity0 flow and staffing to maximize program impact and increase the likelihood of sustainability.

title: Using process indicators to optimize service completion of an @entity2 drug and XXXX brief intervention program.

answer: @entity1


abstract: The activity of protein kinases IKK-   and @entity16 ( @entity16 ) has been shown to be associated with inflammatory diseases. As an inhibitor of IKK-   and @entity16 , amlexanox is an anti-inflammatory, anti- @entity2 , immunomodulator and used for treatment of @entity8 , @entity10 and @entity6 in clinic. We hypothesized that @entity13 may be used for treatment of @entity3 which frequently associated with a low grade of systemic @entity1 . In this study, we investigated the effects of amlexanox on @entity11 -induced osteoclastogenesis in vitro and ovariectomy-mediated @entity7 in vivo. In primary bone marrow derived macrophages (BMMs), amlexanox inhibited osteoclast formation and bone resorption. At the molecular level, amlexanox suppressed @entity11 -induced activation of nuclear factor-kB (NF-kB), mitogen-activated protein kinase (MAPKs), @entity12 and @entity14 . @entity13 decreased the expression of osteoclast-specific genes, including TRAP, @entity9 , @entity15 and @entity14 . Moreover, amlexanox enhanced osteoblast differentiation of BMSCs. In ovariectomized (OVX) @entity0 model, amlexanox prevented OVX-induced @entity7 by suppressing osteoclast activity. Taken together, our results demonstrate that amlexanox suppresses osteoclastogenesis and prevents OVX-induced @entity7 . Therefore, amlexanox may be considered as a new therapeutic candidate for @entity3 , such as @entity4 and @entity5 .

title: Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced XXXX .

answer: @entity7


abstract: We report a case of @entity0 with @entity7 that was treated with @entity1 pulse therapy combined with tonsillectomy. A 27-year-old female was referred to our hospital because of @entity5 and @entity4 . Her urinalysis showed mild @entity4 (0.7 to 0.9 g/day) with dysmorphic red blood cells and cellular casts. Her serum @entity6 level was within the normal range. Renal biopsy specimens revealed mild @entity8 with cellular crescent and adhesion of glomeruli to the Bowman's capsule. Tubulointerstitial changes including mononuclear cell infiltration and tubular atrophy were also observed. Immunohistochemical staining of IgA and C3 was detected in the mesangial area, leading to the diagnosis of @entity0 . She had a past history of @entity7 at 13 years of age and had taken antituberculosis drug for one and a half year. Although treatment with angiotensin receptor antagonist was started, the amount of @entity4 was not changed. @entity1 pulse therapy with tonsillectomy followed by oral @entity3 20 mg/day was conducted. @entity4 and @entity5 gradually decreased. Her respiratory status and chest X-ray had been closely followed up by her respiratory physician. After one and a half years of treatment with low-dose @entity3 , her urinalysis became almost normal. Recurrence of @entity2 was not observed during the follow-up period. The successful outcome of this case encouraged us to treat @entity0 with a past history of @entity2 using interventions including @entity1 pulse therapy.

title: [ @entity1 pulse therapy combined with tonsillectomy in a patient with @entity0 complicated with XXXX ].

answer: @entity7


abstract: Two young males who had no @entity2 died unexpectedly during the night. In one @entity0 , the monitor ECG showed a @entity7 and the electrophysiologic study revealed a sinoatrial conduction time at the upper limit of normal and a prolonged PA interval. The surface ECG showed @entity5 . @entity4 were confined to the night when he died from @entity6 . The ECG of the other @entity0 was normal except for the change in QRS configuration found when the preceding RR interval was prolonged, suggesting a phase 4 block in intraventricular conduction. He was completely free from @entity3 except for the @entity4 which developed around 9:00 p.m. and the @entity6 following an R-on-T type @entity4 which resulted in death during the night. The autopsy showed no @entity2 . ST elevation suggestive of acute @entity1 was not found and the QT intervals were normal in both cases. No electrolyte imbalances were found. These 2 cases can be diagnosed as pokkuri disease which is well known in Japan. The victims are exclusively young males who have no apparent diseases to which death can be attributed.

title: Sudden nocturnal death in young males from XXXX .

answer: @entity6


abstract: OBJECTIVES: The effect of a single-dose systemic @entity7 to treat @entity2 has been previously quantified, but the effect of systemic @entity7 to prevent @entity2 is currently not well defined. The preventive analgesic effect of @entity7 has yet to be quantified in a meta-analysis. The objective of the current investigation was to evaluate the effect of a single preventive dose of systemic @entity7 on @entity2 outcomes. MATERIALS AND METHODS: A wide search was performed to identify randomized controlled trials that evaluated the effects of a single dose of systemic @entity7 on @entity1 outcomes in a large variety of surgical procedures. Meta-analysis was performed using a random-effect model. RESULTS: Eleven randomized clinical trials evaluating 740 @entity0 were included in the analysis. The weighted mean difference (95% confidence interval [CI]) of the combined effects favored @entity7 over control for @entity1 at rest ( <=4 h, -1.1 (-2.0 to -0.2)) and @entity1 at movement (24 h, -1.9 (-2.8 to -1.0)) Postoperative opioid consumption was decreased in the systemic @entity7 group compared with control. Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg @entity6 intravenous equivalents systemic @entity7 also reduced postoperative @entity3 and @entity4 compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9). DISCUSSION: Systemic @entity7 , when used as a single-dose preventive regimen, is an effective intervention to reduce @entity2 . It also reduces @entity5 . Doses >1 g were not associated with greater reduction in @entity1 outcomes.

title: Single-dose Systemic Acetaminophen to Prevent XXXX : A Meta-analysis of Randomized Controlled Trials.

answer: @entity2


abstract: OBJECTIVE: To repair experimental osteochondral knee lesions in @entity1 using tissue engineering. MATERIAL AND METHODS: Eight 40-kg @entity1 underwent surgery. Cartilage and periosteal biopsies of their control knee were taken. Cartilage and periosteal cells were independently isolated, cultured and seeded in biodegradable @entity6 and @entity2 polymers that were fixed on the bottom of an @entity4 in the @entity1 's experimental knee, with bioabsorbable Mitek implants. Four months later the @entity1 were sacrificed and the knees were analyzed with nuclear magnetic resonance imaging (NMRI), macroscopic assessment, histology, electron microscopy (EM), @entity3 ( @entity3 ) and @entity3 element analysis. RESULTS: All the defects were filled with cartilage-like tissue according to the NMRI evaluation and the visual examination. Hyaline-like cartilage was obtained in 3 defects and fibrocartilage in 5. The EM showed chondrocytes in the repair tissue. The @entity3 showed appropriate integration to the bone and the surrounding tissue. @entity3 element analysis showed sulphurized matrix attached to the bone with @entity0 and @entity5 as predominant elements. DISCUSSION: Tissue engineering enabled the production of tissues similar to normal ones. The polymer fixation system was effective.

title: [Results of the experimental repair of osteochondral lesions in a XXXX model using tissue engineering].

answer: @entity1


abstract: Metabotropic @entity5 receptors (mGluRs) are G protein-coupled receptors involved in the regulation of glutamatergic transmission. Recent studies indicate that excitatory group I mGluRs ( @entity7 and @entity8 ) contribute to @entity6 and hyperexcitability during epileptogenesis. In this study, we examined the distribution of mGluR1alpha and @entity8 immunoreactivity (IR) in hippocampal resection tissue from pharmaco-resistant @entity4 ( @entity4 ) @entity0 . IR was detected with panels of receptor subtype specific antisera in hippocampi from @entity4 @entity0 without (non-HS group) and with @entity1 (HS group) and was compared with that of non- @entity2 autopsy controls (control group). By immunohistochemistry and immunoblot analysis, we found a marked increase of @entity8 IR in hippocampi from the non-HS compared with the control group. High @entity8 IR was most prominent in the cell bodies and apical dendrites of hippocampal principal neurons and in the dentate gyrus molecular layer. In the HS group, this increase in neuronal @entity8 IR was even more pronounced, but owing to @entity3 the number of @entity8 -immunoreactive neurons was reduced compared with the non-HS group. IR for mGluR1alpha was found in the cell bodies of principal neurons in all hippocampal subfields and in stratum oriens and hilar interneurons. No difference in mGluR1alpha IR was observed between neurons in both @entity4 groups and the control group. However, owing to @entity3 , the number of mGluR1alpha-positive neurons was markedly reduced in the HS group. The up-regulation of @entity8 in surviving neurons is probably a consequence rather than a cause of the @entity2 and may contribute to the hyperexcitability of the hippocampus in pharmaco-resistant @entity4 @entity0 . Thus, our data point to a prominent role of @entity8 in @entity0 @entity4 and indicate @entity8 signalling as potential target for new anti- @entity2 drugs.

title: Up-regulation of hippocampal metabotropic @entity5 receptor 5 in XXXX @entity0 .

answer: @entity4


abstract: OBJECTIVES: We sought to study the renal circulatory effects of @entity4 in @entity0 with chronic @entity3 ( @entity3 ). BACKGROUND: @entity1 ( @entity1 ) is often reduced in @entity0 with chronic @entity3 and may lead to decreased renal function. The cause of reduced @entity1 is multifactorial and involves systemic as well as local vasoregulatory mechanisms. Stimulation of renal @entity4 A1 receptors in animal models has resulted in a significant vasoconstriction of afferent and efferent glomerular arterioles and deterioration of renal function. Although @entity4 serum levels have been shown to be elevated in @entity0 with @entity3 , their effect on the renal circulation in this @entity0 population has not been studied. METHODS: Nine @entity0 with @entity3 from @entity5 were studied. The effects of @entity4 at a dose of 10(-5) mol/liter infused directly into the main renal artery on heart rate, renal artery blood pressure, renal artery cross-sectional area (measured by intravascular ultrasound), renal Doppler blood flow velocity (measured by a Doppler flow wire in the renal artery), @entity1 and renal vascular resistance (RVR) were evaluated. RESULTS: Infusion of @entity4 resulted in no significant effect on @entity2 but caused a substantial increase in RVR (11,204 +/- 1,469 to 31,494 +/- 3,911 dynes x s x cm(-5), p = 0.0005), which led to a marked fall in @entity1 in every @entity0 (mean values 376 +/- 36 to 146 +/- 22 ml/m2, p = 0.0002). These changes in RVR and @entity1 were associated with no significant change in renal artery cross-sectional area (0.389 +/- 0.040 to 0.375 +/- 0.033 cm2, p = 0.3). CONCLUSIONS: Stimulation of renal @entity4 receptors in @entity0 with @entity3 results in marked renal vasoconstriction that leads to an important reduction in @entity1 . Lack of change in renal artery cross-sectional area suggests that @entity4 affects intrarenal resistance blood vessels rather than large conductance vessels. These results may indicate a rationale for investigation of renal @entity4 receptor blockade for enhancement of @entity1 and improvement of renal function in @entity0 with chronic @entity3 .

title: Renal circulatory effects of @entity4 in XXXX with @entity3 .

answer: @entity0


abstract: UNASSIGNED: As a possible marker of oxidative stress, many studies have measured whole blood reduced @entity3 ( @entity4 ) and @entity6 ( @entity6 ). However, large differences in @entity4 and @entity6 levels reported in different studies, calls for a reliable standardized method. In this study, we validate not only analytical performance of new measurement method for @entity4 and @entity6 , but also the clinical utility of these markers in a @entity1 model with chronic oxidative stress. Twenty @entity1 were randomized into four treatment groups according to @entity2 burden: 0mg, 5mg, 10mg, or 15mg of @entity2 were injected into the peritoneum per day over 4 weeks. To prevent artifactual @entity4 auto-oxidation, we pretreated the sample with @entity5 ( @entity7 ) immediately after sample collection. After protein precipitation using @entity8 , @entity6 and @entity4 - @entity7 were measured using liquid chromatography-tandem mass spectrometry (LC- @entity0 / @entity0 ). The mean @entity4 / @entity6 ratios of the @entity1 model were 163.1, 31.0, 27.9, and 12.8 for control, 5mg, 10mg, and 15mg injection groups, respectively, showing a decrease in the @entity4 / @entity6 ratios according to the amount of oxidative stress induced. Inter-assay coefficients of variation were 4.1% for @entity4 - @entity7 and 7.3% for @entity6 . Recoveries were 98.0-105.9% for @entity4 - @entity7 and 98.0-107.3% for @entity6 . No ion suppression was observed at the retention time for @entity4 - @entity7 and @entity6 . This study suggests an accurate method that can be used for @entity3 measurement using LC- @entity0 / @entity0 , and showed that @entity4 / @entity6 ratio could provide an assessment of the degree of oxidative stress.

title: Validation of a liquid chromatography tandem mass spectrometry method to measure oxidized and reduced forms of XXXX in whole blood and verification in a @entity1 model as an indicator of oxidative stress.

answer: @entity3


abstract: @entity7 are macroscopically visible morphological changes of the mucosa that can develop focal @entity2 in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the @entity7 sequence were primarily based on DNA studies of exophytic, polypoid-type @entity3 . Not all colorectal lesions, however, display an exophytic phenotype and a presumed distinct @entity1 , the nonpolypoid @entity3 , was subsequently described as a precursor of @entity1 . The low incidence of @entity5 mutations in nonpolypoid @entity7 reported previously suggested a different genetic basis for the transformation process in these lesions. We have pursued the identification of genetic changes in benign sporadic nonpolypoid @entity7 in a selected Swedish @entity0 group with no family history of @entity1 . Mutation screening of the @entity6 ( @entity6 ), @entity5 , and @entity4 genes was conducted using the protein truncation test, heteroduplex-single-strand conformation polymorphism analysis, and denaturing gradient gel electrophoresis on PCR-amplified fragments. Fourteen mutations in the @entity6 gene were characterized in 10/20 samples. Mutations in the @entity5 and @entity4 genes were identified in 3/57 and 4/51 @entity3 , respectively. The mutation frequencies and distribution of mutations in @entity6 correlate with published data on exophytic @entity3 . The low mutation frequency of the @entity4 gene is consistent with the benign nature of the research material. @entity5 activation (an early event in polypoid @entity7 ) apparently does not play a significant role in nonpolypoid @entity3 development but may result in the development of a polypoid configuration. Genes Chromosomes Cancer 27:202-208, 2000.

title: Somatic mutations of the XXXX , @entity5 , and @entity4 genes in nonpolypoid @entity7 .

answer: @entity6


abstract: A new venous microdialysis probe for @entity0 was developed. The active area was made with cellulose membrane (220 mm outside diameter, length 20 mm, and 6000 molecular weight cut off). @entity1 measurements were used to test it. The relative recovery was 50% in dialysates obtained in vitro, the step response was 91.8% in the first 2 min. The in vivo recovery was 65.8% obtained by the no net flux method, with the probe placed in the cubital vein of the subjects arms. Corrected @entity1 in dialysates was non significantly different from plasma @entity1 simultaneously collected. In healthy male volunteers from 18 to 37 years of age, mean 22.1 years, the @entity1 levels in the blood dialysates were measured every 30 min, 60 min before and 150 min after an oral load of 75 g of @entity1 or vehicle. @entity1 increased significantly after the load. The differences with the control group were significant at 60 and 90 min after the treatment. The results showed the easy and safe application of this technique to monitor endogenous and exogenous compounds in the extracellular compartment of blood in out @entity0 .

title: Blood microdialysis in XXXX : a new method for monitoring plasma compounds.

answer: @entity0


abstract: INTRODUCTION: @entity1 surgery (EVAR) was introduced a decade ago. Early results are promising, however, there remain concerns regarding the longer-term durability of this technique. Consequently, the national multi-centre EVAR trial has been commenced to define the role of endovascular surgery in the management of @entity2 . DISCUSSION: Successful EVAR requires accurate pre-operative assessment of @entity1 morphology. Current stent-grafts allow 60% of all infra-renal AAA to be treated. Reduced physiological stress and low peri-operative morbidity and mortality rates have been demonstrated with this technique when compared to open repair. Endoleak is an Achilles heel of EVAR, although in itself does not accurately predict outcome. First and second generation devices are estimated to have a 1% per year risk of @entity0 . CONCLUSIONS: Increased understanding of the issues surrounding @entity1 morphology and successful stent-grafting have allowed a major reduction of early type I endoleak. Late endoleak and graft migration remain problematic. @entity3 are risk factors for subsequent @entity0 although the significance of @entity3 remains uncertain. More robust indicators of outcome success/failure are required so that follow-up may be rationalised.

title: Endovascular repair of XXXX : current status.

answer: @entity2


abstract: Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) are now known to have important roles in @entity0 ovarian folliculogenesis. This study determined the expression of the mRNA encoding for BMPs and their receptors in the @entity2 ovary and explored possible roles for them. The expression of the mRNA for @entity7 , and @entity8 was determined and quantified by a semiquantitative RT-PCR. The mRNAs for all the BMPs and receptors determined were present in both the granulosa (G) and theca (T) cells of the F1, F2, and F3 follicles. All BMP mRNAs increased in G cells with follicular development, whereas only @entity6 mRNA had this trend in the T cells. @entity9 mRNAs in T were similar between follicles. BMPR-IA mRNA was similar in F2G and F3G but lower in F1G. BMPR-IB mRNA was similar in G of all follicles, and @entity8 mRNA increased with development. In the T, each receptor subtype showed equal distribution between follicles. mRNA levels for @entity8 were higher in G than in T, suggesting that the G is a major target for BMPs. @entity10 stimulated basal, @entity4 -, and gonadotropin-stimulated @entity1 production by cultured G cells, with differential responses between cells from the F1 and F3/4. This suggests involvement in follicular differentiation. @entity10 reversed the inhibitory effects of transforming growth factor (TGF)-alpha on basal and gonadotropin-stimulated G cell @entity1 production, with greater effect in the F1 than in the F3/4. This effect suggests an important role for BMPs interacting with @entity5 in modulating the effects of gonadotropins and @entity4 on follicular differentiation. Finally, @entity6 stimulated G cell proliferation, but @entity3 inhibited @entity5 + @entity4 - and/or FSH-stimulated G cell proliferation, suggesting a role in the control of follicular growth during development. These effects of @entity10 on the G cell function showed relationships with the expression levels of the BMPs and the @entity8 .

title: BMPs and BMPRs in @entity2 ovary and effects of @entity10 on granulosa cell proliferation and XXXX production in vitro.

answer: @entity1


abstract: OBJECTIVE: To evaluate the relationship between caries and @entity2 in the early and late mixed dentition in a population of @entity0 of Chinese migrant workers in Shanghai. METHODS: Dental charts were obtained for 646 @entity0 in the mixed dentition, aged between 6 and 13 years old. The decayed, missing, and filled teeth (DMFT) index and interproximal tooth structure lost due to caries (ITSLC) were evaluated. RESULTS: In the early mixed dentition, @entity1 was more likely to be ideal in subjects with DMFT > 0. In the late mixed dentition, crowding in both arches was greater in subjects with DMFT > 0. In the total sample, crowding in the lower arch only was greater in subjects with DMFT > 0. In the early mixed dentition, @entity2 was lower in subjects with ITSLC in the upper arch and in both arches and the rate of anterior crossbite was higher in subjects with ITSLC in the upper arch. In the late mixed dentition, @entity1 was more likely to be ideal in subjects with ITSLC in the upper arch and @entity2 was greater in subjects with ITSLC in both arches. In the total sample, @entity1 was more likely to be ideal in subjects with ITSLC in the upper arch and lower crowding was greater in subjects with ITSLC in both arches. CONCLUSION: A relationship exists between caries and @entity2 , and between ITSLC and @entity2 , and some relationships may change with dental age.

title: The Relationship between Caries and Malocclusion in Chinese Migrant Workers' XXXX in Shanghai.

answer: @entity0


abstract: During retrospective and prospective studies, we attempted to determine the clinical characteristics, treatment, and visual outcome of @entity0 with @entity7 and to evaluate the association between @entity7 and @entity2 ( @entity2 ). The retrospective study included 44 @entity0 with @entity7 , who had been examined between October 1986 and January 1999. We analyzed age, sex, visual acuity (VA), median follow-up time, and medical and surgical treatments. The prospective study, which included 21 consecutive @entity0 with @entity7 , was performed to determine the presence of @entity2 . In the retrospective study, the mean @entity0 age was 22.4 years (SD +/- 11.5) and the median follow-up was 34.9 months (SD +/- 27.2). Complications included macular @entity1 (47.7%), vitreous opacities (38.6%), @entity6 (38.6%), @entity5 (36.4%), and @entity4 (20.5%). Forty @entity0 (90.9%) had a final bilateral VA better than 20/40. In the prospective study, @entity8 ( @entity8 ) was performed. @entity3 were found in 10 (47.6%) of the 21 @entity0 and relapsing-remitting clinically definite @entity2 was diagnosed in seven (33.3%). With the exception of age, no significantly statistical differences were observed when the visual prognosis and the clinical and epidemiologic characteristics were compared between the two groups of @entity0 with and without associated @entity2 ; a diagnosis of @entity2 was more frequently made in @entity0 over 25 years of age. With appropriate treatment, @entity0 with @entity7 have a good visual prognosis. Because the presence of @entity3 seems to be high among @entity0 with @entity7 , @entity8 should be considered, especially in @entity0 over 25 years of age.

title: XXXX : epidemiology, treatment, and association with @entity2 .

answer: @entity7


abstract: UNASSIGNED: Nano- @entity2 (nano- @entity1 ) is one of the most universal engineered nano-materials while @entity3 ( @entity4 ) is a typical new persistent organic pollutant. They are widely used and present in aquatic environment. In this study, a novel semi-static multilayer microcosm was setup to investigate the impacts of nano- @entity1 on @entity4 bioaccumulation in fish species [ @entity0 ( @entity0 ), @entity5 ( @entity5 ), Hypostomus plecostomus (H. plecostomus)] living in different vertical layers. As a result of aggregation and deposition, the concentration of @entity1 increased from upper to bottom layers in the water column. Concomitantly, due to adsorption of @entity4 on the nano- @entity1 particles, @entity4 also displayed an increasing trend from upper to bottom layer. Owing to ingestion of the @entity1 - @entity4 complexes, more @entity4 was taken-up by fish. With the aid of intestinal fluid, @entity4 was readily released from @entity1 particles and absorbed by fish. As a result, accumulation of @entity4 in whole fish was facilitated and the bioaccumulation factors of @entity4 in @entity0 , @entity5 and H. plecostomus were 3.01, 2.42 and 1.11 times of that in the groups without @entity1 . However, @entity1 aggregates were too large to penetrate biological membranes to participate body circulation, and no significant accumulation of @entity1 was observed in fish muscle. The results suggested that the ecological risk of @entity4 could be enhanced due to the presence of nano- @entity1 in water.

title: Effects of nano- XXXX on @entity3 bioaccumulation in fishes living in different water layers: Implications for enhanced risk of @entity3 .

answer: @entity1


abstract: BACKGROUND: @entity1 @entity0 suffer from @entity2 and exercise limitation. The aim of this study was to establish whether a physical training program improves these and other outcomes important to @entity1 @entity0 . METHODS: From 11/2012 to 9/2014, 201 @entity1 @entity0 were referred to the ild care expertise team, Ede, the Netherlands. In our center, all @entity0 are routinely recommended to undergo testing at baseline to determine their physical functioning and encouraged to complete a 12-week, supervised physical training program. Ninety @entity0 underwent baseline testing and returned for repeat testing at 3  months in the interim, 49 completed the training program (Group I) and 41 chose not to participate (Group II). Change over time (from baseline to 3  months) in @entity2 , exercise capacity, and skeletal muscle strength were assessed between the two groups. RESULTS: At baseline, there were no between-group differences for @entity2 , DLCO  %, FVC  %, or exercise capacity [assessed by percent predicted six-minute walk distance (6MWD  %) and Steep Ramp Test (SRT)]. The 6MWD for Group I improved between baseline and 3  months, while the 6MWD remained the same in Group II (F  =  72.2, p  <  0.001). Group I showed a significantly larger decrease of @entity2 compared with Group II (F  =  6.27, p  =  0.014). Lung function tests did not change in either group. CONCLUSION: A supervised physical training program improves exercise capacity and @entity2 among @entity1 @entity0 and should be included in their management regimen.

title: Benefits of Physical Training in XXXX .

answer: @entity1


abstract: @entity6 is the major cause of morbidity and mortality in the elderly in the United States. In this age group, the clinical presentation of @entity4 can be quite atypical. In general, the incidence of typical precordial chest pressure/ @entity3 denoting @entity9 is less common, whereas @entity12 as an anginal-equivalent symptom is frequent. The diagnosis of @entity2 @entity3 is frequently confused by the many comorbid conditions present in the elderly. Even when classic @entity2 precordial discomfort is present, it tends to be less severe and less well defined. The elderly appear to have reduced @entity3 perception; as a result, silent @entity9 is more common and carries a somewhat worse prognosis in the elderly than in younger age groups. Similarly, the presenting symptoms of @entity7 in the elderly can be nonspecific. The classic crushing substernal chest @entity3 decreases with age, whereas the symptom of @entity12 gradually increases. @entity1 , @entity10 states, @entity5 , and worsening @entity8 are common clinical presentations of an acute @entity11 in elderly @entity0 . Silent (unrecognized) @entity7 are common in the elderly and carry serious prognostic implications.

title: Clinical manifestations of @entity7 in older XXXX .

answer: @entity0


abstract: Proper brain function requires stringent balance of excitatory and inhibitory synapse formation during neural circuit assembly. Mutation of genes that normally sculpt and maintain this balance results in severe @entity4 , causing @entity2 including @entity7 , @entity3 and @entity8 . Such mutations may result in defective architectural structuring of synaptic connections, molecular assembly of synapses and/or functional synaptogenesis. The affected genes often encode synaptic components directly, but also include regulators that secondarily mediate the synthesis or assembly of synaptic proteins. The prime example is @entity6 ( @entity6 ), the leading heritable cause of both @entity5 and @entity1 . @entity6 results from loss of mRNA-binding @entity9 , which regulates synaptic transcript trafficking, stability and translation in activity-dependent synaptogenesis and plasticity mechanisms. Genetic models of @entity6 exhibit striking excitatory and inhibitory synapse imbalance, associated with impaired cognitive and social interaction behaviors. Downstream of translation control, a number of specific synaptic proteins regulate excitatory versus inhibitory synaptogenesis, independently or combinatorially, and loss of these proteins is also linked to disrupted neurodevelopment. The current effort is to define the cascade of events linking transcription, translation and the role of specific synaptic proteins in the maintenance of excitatory versus inhibitory synapses during neural circuit formation. This focus includes mechanisms that fine-tune excitation and inhibition during the refinement of functional synaptic circuits, and later modulate this balance throughout life. The use of powerful new genetic models has begun to shed light on the mechanistic bases of excitation/inhibition imbalance for a range of @entity0 states.

title: Genetic controls balancing excitatory and inhibitory synaptogenesis in XXXX models.

answer: @entity2


abstract: @entity1 ( @entity1 ) proteoglycans have been implicated as molecules that are involved in axon guidance in the developing neural pathways. The spatiotemporal expression of @entity1 was investigated in the developing retinofugal pathway in @entity0 embryos by using the @entity1 -56 antibody. Immunoreactive @entity1 was detected in inner regions of the retina as early as embryonic day 11 (E11). Its expression in subsequent stages of development followed a centrifugal, receding gradient that appeared to correlate with the sequence of axogenesis in the retina. In the chiasm, immunoreactive @entity1 was expressed at E12, before the arrival of retinal axons. When the retinal axons navigated in the chiasm at E13-E14, immunoreactive @entity1 remained at a low level in the optic fiber layer of the chiasm but was observed prominently in the caudal parts of the ventral diencephalon. This pattern followed closely the array of stage-specific-embryonic-antigen-1-positive neurons in the ventral diencephalon, with a V-shaped configuration that bordered the posterior boundary of the retinal axons, and a rostral raphe extension that ran across the decussating axons in the chiasm. Thus, the @entity1 is implicated in patterning the course of early retinal axons and in regulating axon divergence in the chiasm. At the lateral region of the chiasm, where the retinal axons cross the midline and approach the optic tract, a @entity1 -immunopositive region coincided with the region in which active sorting of dorsal retinal axons from ventral retinal axons occurs. Moreover, at the threshold of the optic tract, the immunoreactive @entity1 was restricted only to the deep part of the optic fiber layer, suggesting an inhibitory role of the @entity1 in repelling newly arrived axons to superficial regions of the optic tract during the development of chronotopic order at this part of the retinofugal pathway.

title: Expression of chondroitin sulfate proteoglycans in the chiasm of XXXX embryos.

answer: @entity0


abstract: BACKGROUND: Although the @entity3 ( @entity3 ) is increasingly performed for hemodialysis vascular access in @entity0 lacking adequate superficial veins, little is known about the long-term patency or risk factors for failure. METHODS: A retrospective analysis was conducted for 99 @entity0 who had a @entity3 created between April 1997 and October 2001. Primary outcomes were unassisted and assisted patency rates and primary failure rates. RESULTS: This was the first access procedure in 46% of @entity0 , mean age was 55 years, and 46% were @entity0 . Unassisted and assisted patency rates were 47% and 64% at 1 year and 41% and 58% at 2 years, respectively. @entity2 occurred in 23% of cases. Unassisted access patency was significantly worse in @entity0 with a previous access (relative risk [RR], 2.04; confidence interval [CI], 1.09 to 3.85; P = 0.03) or an ipsilateral central venous catheter (RR, 2.92; CI, 1.34 to 6.38; P < 0.01). @entity2 was affected by older age (RR, 2.0; CI, 1.20 to 3.38; P < 0.01), @entity1 (RR, 7.1; CI, 1.65 to 30.1; P < 0.05), and a previous vascular access (RR, 6.4; CI, 1.49 to 27.6; P = 0.01). @entity4 requiring intervention occurred in 5% of cases. CONCLUSION: In summary, the @entity3 provides a viable option for vascular access; however, certain @entity0 characteristics seem to affect long-term patency and should be considered when exploring access options.

title: Vascular access outcomes using the XXXX .

answer: @entity3


abstract: Isolation of the temperature-sensitive @entity1 mutant 72c has been described previously. The mutant allele was named fusB and causes a pleiotropic phenotype, the most striking features of which, besides temperature sensitivity, are the inability to grow on synthetic medium and supersensitivity to @entity0 , an antibiotic that inhibits the C1 metabolism. This work shows that the fusB mutation is a frameshift mutation in the nadD gene that encodes @entity7 adenylyltransferase. The frameshift leads to a change of the last 10 @entity5 and an addition of 17 @entity5 . This lesion, renamed nadD72, leads to very little @entity6 + and @entity4 synthesis at the permissive temperature and essentially no synthesis at the non-permissive temperature. As a comparison, a new mutation in the nadD gene, with an @entity2 change in the @entity3 -binding site, has been isolated. Its @entity6 + synthesis is decreased at 30 degrees C but the level is still sufficient to support normal growth. At 42 degrees C, @entity6 + synthesis is reduced further, which leads to temperature sensitivity on minimal medium. This mutation was designated nadD74. Thus, a small decrease in @entity6 + levels affects ability to grow on minimal medium at 42 degrees C, while a large decrease leads to a more pleiotropic phenotype.

title: fusB is an allele of nadD, encoding @entity7 adenylyltransferase in XXXX .

answer: @entity1


abstract: A study has been made of the roles played by complement and @entity3 ( @entity3 ) in the acute destruction of xenografts of @entity1 skin that follows injection of their hosts with antisera specifically reactive with graft antigens. The @entity1 skin was grafted onto @entity0 whose immune responses were suppressed by removal of the thymus and a brief course of treatment with rabbit antimouse lymphocyte serum. At about 2 wk after grafting the @entity0 were injected intravenously or intraperitoneally with mouse antirat serum (MARS). This time interval was chosen because it avoided the complications that might be associated with either the process of healing in or with incipient rejection. Signs of graft damage were evident as early as 10 min after the injection of MARS, and in most animals so injected the grafts were completely destroyed within 24-48 h. The role of complement (C) in this acute destructive process is indicated by the results of three lines of experimentation. (a) Non-C-fixing antibodies or antibody fragments failed to cause damage to the grafts. Indeed, both chicken antirat serum and F(ab')(2) fragments from rabbit antirat serum completely protected the grafts against the effects of MARS that was administered 24 h later. (b) When @entity0 were depleted of hemolytic C by treatment with cobra venom factor or heat-aggregated gamma globulin, the damage caused by MARS was greatly reduced or completely inhibited. (c) In @entity0 with a genetically determined absence of C5 much greater quantities of MARS were required to cause graft damage; the tempo of the destructive process was consistently slower; and a greater number of grafts recovered from the initial inflammatory process than was the case for animals with an intact complement system. The participation of @entity3 in serum-mediated destruction of grafts was initially suggested by the results of microscope examination of fixed tissues. The essential role of these cells in the process is indicated by the failure of MARS to cause tissue damage in @entity0 whose circulating @entity3 have been reduced to very low levels by treatment with @entity2 mustard or more specifically with an anti- @entity3 serum. The absence of tissue damage when circulating @entity3 are reduced but C levels are normal suggests that C-mediated cytolysis is unimportant in graft destruction and that the role of C lies in its ability to generate chemotactic factors. The latter may then attract the @entity3 that provide mediators of tissue damage.

title: Acute destruction by humoral antibody of XXXX skin grafted to @entity0 .

answer: @entity1


abstract: OBJECTIVES: Using an adult cohort of @entity0 with @entity5 , we aimed to identify risk factors for development of @entity3 ( @entity3 ), which if identifiable would allow @entity0 to receive earlier treatment and more specifically individualized treatment plans. METHODS: For the case-control study, 118 @entity0 with @entity5 ( @entity5 ) between the ages of 18 and 75 were included after selection from a database of 800 @entity0 referred from throughout the Saskatchewan Epilepsy Program. Definitions were used in accordance with ILAE criteria. The odds ratio and its confidence interval were calculated. We performed a logistic regression analysis. RESULTS: Forty-four (37%) @entity0 fulfilled the definition of @entity3 (cases), and @entity4 in 74 (63%) @entity0 were not intractable (controls). @entity0 with @entity3 were significantly younger than the controls at the onset of @entity3 (6.6 vs. 18.8years, p=<0.001). Significant variables on univariate analysis were the following: @entity3 diagnosed prior to 12years (OR: 12.1, CI: 4.8-29.9, p<0.001), previous history of @entity1 (OR: 15.1, CI: 3.2-70.9, p<0.001), @entity2 (OR: 12.6, CI: 4.9-32, p<0.001), and @entity3 (OR: 10.5, CI: 3.9-27.8, p<0.001). Our study showed some protective factors for @entity3 such as a good response to first AED, idiopathic etiology, and history of @entity4 . In the logistic regression analysis, two variables remained statistically significant: @entity2 and more than one @entity4 type. CONCLUSION: Our study has identified a set of variables that predict @entity3 in @entity0 with @entity5 . Risk factors identified in our study are similar to those previously identified in pediatric studies, however, our study is specifically tailored to adult @entity0 with @entity5 .

title: Predicting drug resistance in adult XXXX with @entity5 : A case-control study.

answer: @entity0