abstract: BACKGROUND: @entity1 ( @entity1 ) ablation is superior to pharmacologic therapy in achieving maintenance of normal sinus rhythm in selected @entity0 populations. However, the procedure is resource intensive, and repeat ablations are sometimes required. We examined the predictors and trends of repeat ablation using a large national administrative claims database. METHODS: Privately insured and Medicare Advantage @entity0 who underwent catheter ablation for @entity1 between January 1, 2004, and September 30, 2014, were included in the study. The primary outcome was repeat @entity1 ablation during enrollment. We examined the associations between repeat ablation and @entity0 demographics (age, gender, socioeconomic demographics), comorbid conditions (CHA2DS2-Vasc score and Charlson index), and year of the index ablation. Cox proportional hazard models were used to identify predictors of repeat ablation. RESULTS: We included 8,648 adult @entity0 in the analysis. Median age was 61.0 (interquartile range [IQR] 54-68) years, and 70.9% were @entity0 . Median follow-up was 1.1 (IQR 0.5-2.3) years. A total of 1,263 @entity0 underwent repeat ablation (14.6%) over a total of 14,280 @entity0 -years (12.1% at 1 year). The hazard ratio (HR) for repeat ablation was higher in younger @entity0 (HR 0.75 [0.61-0.91; P < .01] for age 65-75 and 0.55 [0.4-0.75; P < .001] for age >= 75 compared with age 18-54), those with higher household income (HR 1.24 [1-1.54; P < .05] for household income >=  100,000 compared with household income < 40,000), @entity0 treated in the south (HR 1.15 [1-1.31]; P < .05), and those on antiarrhythmic medications (HR 1.15 [1.01-1.31]; P < .05). In particular, younger @entity0 (ages 18-54 years) continued to undergo repeat ablations over the entire follow-up period, and the cumulative rate was approximately 40% among those followed for 5 years. Clinical characteristics including those included in the CHA2DS2-Vasc score and Charlson index did not predict likelihood of repeat ablation. The rate of repeat ablation remained constant over the available follow-up. CONCLUSION: Approximately 1 in 8 @entity0 treated with catheter ablation for @entity1 will undergo a second procedure within 1 year, although the rate is as high as 40% in young @entity0 at 5 years. The rate of repeat ablation appears to be associated with demographic characteristics (younger age and higher household income) rather than medical comorbidities.

title: Trends and predictors of repeat catheter ablation for XXXX .

answer: @entity1


abstract: BACKGROUND: Surgical implantation of recombinant @entity0 @entity7 (rhBMP-2) in an absorbable collagen sponge carrier ( @entity8 ) significantly enhances bone regeneration in horizontal alveolar defects; however, sufficient quantities of bone for implant dentistry are not routinely obtained. PURPOSE: The objective of this proof-of-principle study was to evaluate the potential of a space-providing macroporous expanded @entity6 (ePTFE) device to control volume and geometry of rhBMP-2/ @entity8 -induced @entity4 . MATERIALS AND METHODS: Bilateral critical-size supra-alveolar periimplant defects were created in four Hound-Labrador mongrel @entity3 . Two turned and one surface-etched 10 mm @entity5 dental implants were placed 5 mm into the surgically reduced @entity2 creating 5 mm supra-alveolar defects. rhBMP-2/ @entity8 (0.4 mg rhBMP-2) was placed around the exposed dental implants. Additionally, one jaw quadrant in each animal was randomly assigned to receive the dome-shaped macroporous ePTFE device. Mucoperiosteal flaps were advanced for primary wound closure. The animals were euthanized at 8 weeks post surgery for histometric analysis. RESULTS: The space-providing macroporous ePTFE device defined the volume and geometry of rhBMP-2/ @entity8 -induced bone formation, whereas bone formation at sites receiving rhBMP-2/ @entity8 alone varied considerably. Vertical @entity1 at turned dental implants averaged (+/-SD) 4.7 +/-0.2 mm at sites receiving @entity8 and the ePTFE device compared with 3.5 +/-0.9 mm at sites receiving rhBMP-2/ @entity8 only. The corresponding values for rhBMP-2/ @entity8 -induced bone area were 9.6 +/- 0.7 mm2 and 7.5 +/-6.2 mm2. There was a highly significant correlation between induced bone area and the space provided by the ePTFE device (p <.001). There was no difference in induced bone density or bone-implant contact between the two technologies. These observations were consistent with those observed at surface-etched dental implants. CONCLUSIONS: The data from this study suggest that a space-providing macroporous ePTFE device defines rhBMP-2/ @entity8 -induced @entity2 to provide adequate bone quantities for implant dentistry. The dental implant surface technology does not appear to substantially influence bone formation.

title: Space-providing expanded @entity6 devices define @entity2 at dental implants induced by recombinant XXXX @entity7 in an absorbable collagen sponge carrier.

answer: @entity0


abstract: UNASSIGNED: Increasing results suggest microRNAs (miRNAs) could function important roles in @entity0 progression. miR-30a-5p is downregulated in variety of @entity0 and acts as a @entity0 suppressing gene. The functions and molecular mechanisms of miRNA-30a-5p in @entity3 ( @entity3 ) remain unclear. In the present study, quantitative real-time PCR (qRT-PCR) was used to detect miR-30a-5p expression in 16 pairs of @entity3 and their adjacent non-cancerous tissues and @entity3 cell lines. By overexpression of miRNA-30a-5p, CCK-8 and colon formation assay were used to evaluate cell growth and flow cytometry to evaluate cell apoptosis. Western blot was used to test protein expression. And potential mechanisms were analyzed with luciferase activity assay. In vivo @entity0 growth was observed with @entity1 . Our results showed that miR-30a-5p expression in @entity3 tissues was significantly lower compared to adjacent non-cancerous liver tissues, and lower miR-30a-5p expression was also observed in @entity3 cell lines compared to normal liver cell. Luciferase assay showed that @entity6 ( @entity6 ) mRNA was a direct target of miR-30a-5p. A significant reverse correlation between miR-30a-5p and @entity6 in @entity2 tissues was observed. miR-30a-5p overexpression in @entity3 cells significantly inhibited cell proliferation, colon formation, and induced apoptosis while @entity6 overexpression reversed growth inhibition and apoptosis induction of miRNA-30a-5p in @entity3 cells. miRNA-30a-5p upregulated phosphatase and tensin homolog ( @entity5 ) protein expression and thus inhibited @entity4 activating by targeting @entity6 . miRNA-30a-5p also significantly inhibited @entity0 growth in vivo. Our results suggest that underexpression of miR-30a-5p might function as a @entity0 suppressing miRNA by directly targeting @entity6 in @entity3 and is therefore a potential candidate biomarker for @entity3 targeting therapy.

title: Overexpression of microRNA-30a-5p inhibits @entity2 cell proliferation and induces apoptosis by targeting @entity6 / @entity5 / XXXX pathway.

answer: @entity4


abstract: To determine the overall survival and @entity3 for @entity0 treated with salvage definitive chemo-radiotherapy after primary surgery for locoregional relapse of @entity2 . A retrospective review of 525 @entity0 who had a resection for oesophageal or oesophagogastric @entity2 at Princess Alexandra Hospital identified 14 @entity0 treated with salvage definitive radiotherapy or chemo-radiotherapy, following localized recurrence of their disease. We analysed the @entity0 and treatment characteristics to determine the median overall survival as the primary end point. @entity3 was examined to determine if increased @entity1 occurred when the stomach was irradiated within the intrathoracic radiotherapy field. The median overall survival for @entity0 treated with curative intent using salvage definitive chemo-radiotherapy was 16 months and the 2-year overall survival is 21%. One @entity0 is in clinical remission more than 5 years after therapy. Age <60 years old and nodal recurrence were favourable prognostic factors. Treatment compliance was 93% with only one @entity0 unable to complete the intended schedule. Fourteen per cent of @entity0 experienced grade 3 or 4 @entity3 . Salvage definitive chemo-radiotherapy should be considered for good performance status @entity0 with @entity2 who have a locoregional relapse after primary surgery. The schedule is tolerable with low @entity1 and an acceptable median survival.

title: Salvage definitive chemo-radiotherapy for locally recurrent XXXX after primary surgery: retrospective review.

answer: @entity2


abstract: PURPOSE: The impact of intraoperative @entity4 on postoperative @entity1 after elective repair of an @entity2 was evaluated. METHODS: Chart review of a prospectively accrued database was performed for @entity0 admitted from January 1, 2003, through December 31, 2013. @entity0 were included in the study if they underwent elective repair of an unruptured @entity3 with surgical clipping or wrapping. The primary objective was to determine if the use of @entity4 increased @entity0 ' odds of having a @entity1 within six hours of surgical intervention. Univariate comparisons were conducted on all variables for @entity0 who received @entity4 and @entity0 who were treated with other antibiotics. Multivariable logistic regression was performed to assess the impact of @entity4 administered intraoperatively on postoperative @entity1 , while accounting for other covariates. RESULTS: Of the 520 @entity0 included, 53 (10.2%) @entity0 developed @entity1 within six hours after surgery. A total of 439 (84.4%) @entity0 received @entity4 intraoperatively. There were no differences in baseline characteristics between the @entity0 who received @entity4 compared with those who did not. The frequency of @entity1 did not significantly differ between @entity0 treated with @entity4 versus other antibiotics (11.2% versus 4.9%, respectively; p = 0.08). Multivariable regression revealed that the use of @entity4 did not increase the odds of having a @entity1 postoperatively compared with @entity0 treated with other antibiotics (odds ratio, 2.4; 95% confidence interval, 0.82-7.15). CONCLUSION: No relationship was found between the intraoperative use of @entity4 and the development of @entity1 during the six hours after the repair of unruptured @entity2 .

title: Impact of intraoperative @entity4 on postoperative XXXX after elective repair of @entity2 .

answer: @entity1


abstract: Aptamers, that exist naturally in living cells as functional elements and can switch nonfluorescent natural targets to fluorophores, are very useful in developing highly sensitive and selective biosensors and screening functional agents. This work demonstrates that @entity0 telomeric G-quadruplex (HTG) can serve as a potential fluorophore-switching aptamer (FSA) to target a natural @entity6 . We found that, among the G-quadruplexes studied here and the various structurally similar alkaloids including @entity8 (EPI), @entity2 (BER), @entity3 ( @entity5 ), @entity10 (JAT), @entity7 (COP), @entity11 (WOR), @entity4 (SAN), @entity1 (CHE), and @entity9 (NIT), only the HTG DNA, especially with a 5'-TA-3' residue at the 5' end of the G-quadruplex tetrad (5'-TAG3(TTAG3)3-3', TA[Q]) as the minimal sequence, is the most efficient FSA to selectively light up the EPI fluorescence. Compared to the 5' end flanking sequences, the 3' end flanking sequences of the tetrad contribute significantly less to the recognition of EPI. The binding affinity of EPI to TA[Q] (Kd = 37 nM) is at least 20 times tighter than those of the other alkaloids. The steady-state absorption, steady-state/time-resolved fluorescence, and NMR studies demonstrate that EPI most likely interact with the 5' end flanking sequence substructure beyond the core [Q] and the G-quadruplex tetrad in a much more specific manner than the other alkaloids. The highly selective and tight binding of EPI with the FSA and significantly enhanced fluorescence suggest the potential development of a selective EPI sensor (detection limit of 10 nM). More importantly, EPI, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart. Furthermore, EPI can bind stoichiometrically to each G-quadruplex unit of long HTG DNA multimer with the most significant fluorescence enhancement, which has not been achieved by the previously reported probes. Our work suggests the potential use of EPI as a bioimaging probe and a therapeutic DNA binder.

title: Selective Lighting Up of @entity8 Alkaloid Fluorescence by Fluorophore-Switching Aptamer and Stoichiometric Targeting of XXXX Telomeric DNA G-Quadruplex Multimer.

answer: @entity0


abstract: BACKGROUND AND AIM: The purpose of this study was to describe the computed tomography (CT) findings of @entity4 -treated @entity2 in @entity0 with @entity3 and to correlate the findings to the overall survival (OS). METHODS: Twenty-eight @entity4 -treated @entity0 who had @entity3 ( @entity3 ) with viable @entity2 between August 2007 and February 2008 were enrolled in the study. Dynamic CT findings were analyzed with regard to the response of the @entity1 , based on the response evaluation criteria in solid @entity1 , version 1.1, and the attenuation values of the @entity1 during the late arterial and portal venous phases. Survival analyses according to early changes in the @entity1 were also performed. RESULTS: In all @entity0 , the @entity1 responses were stable disease or progressive disease on follow-up CT scans. Prior to the treatment, the mean attenuation values of the @entity1 were 93.0    20.0 Hounsfield unit (HU) at the late arterial phase, and 107.9    23.0 HU at the portal venous phase. On the first follow-up CT scans, the mean attenuation values of the late arterial and portal venous phases were 76.9    26.5 HU and 94.2    29.1 HU, respectively (P < 0.01). The median OS was better for the @entity0 with the response of stable disease than the @entity0 with progressive disease (P = 0.013). CONCLUSIONS: In @entity0 with advanced @entity3 who were treated by @entity4 , the size of the @entity2 was not significantly reduced. However, the median survival was better for the @entity0 with the response of stable disease. The attenuation values of the @entity1 became lower after treatment, as compared to the baseline CT scans.

title: Computed tomography findings of @entity4 -treated @entity2 in @entity0 with XXXX .

answer: @entity3


abstract: UNASSIGNED: 2040 Background: @entity11 is a novel @entity9 that has demonstrated exceptional activity in @entity0 xenograft models when administered intravenously and orally. Preclinical studies of @entity11 have shown antitumor activity in MDR-expressing and @entity7 -resistant @entity1 . METHODS: This phase 1 ascending-dose study was performed to determine the safety and tolerability of orally administered @entity11 given once every 21 days. Preliminary antitumor activity of @entity11 was also examined. Key eligibility criteria included adult @entity0 with refractory solid @entity1 , good performance status (ECOG <=  2), and adequate hematologic, hepatic, and renal function. Plasma pharmacokinetic (PK) sampling was performed during the first cycle of therapy. RESULTS: 18 @entity0 (4 females, 14 males) were evaluated at 5 dose levels ranging from 25 to 75 mg/m(2). Treatment was well tolerated at the first 3 dose levels (25, 37, 50 mg/m(2)). Two @entity0 developed dose-limiting @entity2 (DLTs) at 75 mg/m(2) (1 @entity0 with grade 3 @entity8 with @entity3 , another @entity0 had grade 4 @entity8 with @entity3 ). Three @entity0 were treated at an intermediate dose level of 60 mg/m(2) without DLTs. Other common @entity2 included grade 1-2 fatigue and grade 1-2 @entity5 . Disease stabilization was seen in 4 @entity0 with the following @entity1 : mesothelioma (14 cycles), @entity6 (12 cycles), @entity10 (10 cycles), and @entity4 (6 cycles). There was substantial interpatient variability in the PK parameters. @entity11 was absorbed rapidly with mean Tmax less than 1 hour. Mean Cmax and AUC values generally increased in a dose-related manner. The elimination half-life ranged from 20-228 hours. CONCLUSIONS: @entity11 can be safely administered orally once every 21 days up to a dose of 60 mg/m(2). The major DLT was @entity3 . Four @entity0 had disease stabilization. This study is ongoing to confirm 60 mg/m(2) as the maximum tolerated dose and to determine the oral bioavailability of @entity11 . [Table: see text].

title: Phase 1 trial of oral @entity11 in subjects with advanced XXXX .

answer: @entity1


abstract: BACKGROUND: A descriptive cross-sectional study was carried out to assess the dental caries and @entity2 status of elderly residing in old age homes of Madhya Pradesh, India. MATERIALS AND METHODS: The study was carried out on 599 elderly @entity0 residing in old age homes of Madhya Pradesh, India using cluster sampling methodology. The clinical findings were recorded using modified WHO Oral Health Assessment form (1997) to assess periodontal status as per community periodontal index, loss of attachment, WHO dentition status, and treatment needs. RESULTS: In the present study, the caries prevalence among dentate subjects was found among 41.9% of the dentate subjects and the mean decayed, missed, and filled teeth was found to be 8.28    4.779 with the mean number of decayed being 1.51. In the dentate population, 0% had healthy periodontal tissue, 0.26% had @entity1 , and 24.5% had calculus, 52.1% had shallow pockets and 23.1% had deep pockets as their highest score and this difference was statistically significant (P < 0.05). In the current study, 37.9% inmates were completely edentulous. This study also showed that as age advanced the prevalence increased from 23.1% to 55.4%. The difference was statistically significant (P < 0.05). CONCLUSION: The oral health status of elderly @entity0 was found to be poor. Hence, it is concluded from this study that @entity3 is higher among the geriatric group residing in old age homes and is associated with many demographic and behavioral risk indicators.

title: Assessment of Dental Caries and XXXX Status among Elderly Residing in Old Age Homes of Madhya Pradesh.

answer: @entity2


abstract: PURPOSE: The purpose of this study was to compare the outcomes of @entity0 treated with chemoradiotherapy with a complete clinical response followed by either a "watch and wait" strategy or a total mesorectal excision. METHODS: This was an observational retrospective study from a single institute. @entity0 with locally advanced @entity1 following chemoradiotherapy with a complete clinical response from January 1, 2007 to December 31, 2014 were included. RESULTS: The study population consisted of 18 @entity0 who opted for a "watch and wait" policy and 26 @entity0 who underwent radical surgery after achieving a complete clinical response. @entity0 had no documented treatment complications under the watch and wait policy, while 13 @entity0 who underwent radical surgery experienced significant morbidity. There were two local recurrences in the watch and wait group; both were treated with salvage resection and had no associated mortality. In the radical surgery group, 1 @entity0 showed an incomplete pathologic response (ypT0N1), and the remaining 25 @entity0 showed complete pathologic responses; 1 had a distant recurrence, which was managed non-operatively, and 2 @entity0 died of unrelated causes. The 5-year overall survival rate and median disease-free survival time were 100  % and 69.78  months in the watch and wait group and 92.30  % and 89.04  months in the radical surgery group. CONCLUSIONS: A watch and wait policy avoids the morbidity associated with radical surgery and preserves oncologic outcomes in our retrospective study from a single institute. It could be considered a therapeutic option in @entity0 with locally advanced @entity1 following chemoradiotherapy with a complete clinical response.

title: XXXX with complete clinical response after neoadjuvant chemoradiotherapy, surgery, or "watch and wait".

answer: @entity1


abstract: BACKGROUND: Evidence implicated the diagnostic significance of microRNAs in whole urine/urine sediments in @entity2 of the bladder (UCB). However, the contaminated blood cells in @entity0 with haematouria significantly altered the expression profiles of urinary microRNA, influencing the test accuracy. METHODS: MicroRNA profiles of the urine supernatants of UCB @entity0 and controls without any @entity1 and profiles of malignant and corresponding normal mucosa tissues from the @entity0 were determined by microRNA microarray and compared to identify differentially expressed microRNAs. The differential expression was verified in the tissues of an independent @entity0 cohort by RT-qPCR. The diagnostic significance of selected microRNAs as biomarkers in the urine supernatant was investigated in the expanded cohorts. RESULTS: @entity4 and microRNA-125b were down-regulated in the urine supernatants of UCB @entity0 . The degree of down-regulation was associated with the @entity1 grade. A diagnostic model was developed using a combined index of the levels of @entity4 and microRNA-125b in the urine supernatant with a sensitivity of 86.7%, a specificity of 81.1% and a positive predicted value ( @entity3 ) of 91.8%. Discriminating between high- and low-grade UCB, the model using the level of microRNA-125b alone exhibited a sensitivity of 81.4%, a specificity of 87.0% and a @entity3 of 93.4%. CONCLUSIONS: The results revealed a unique microRNA expression signature in the urine supernatants of UCB @entity0 for the development of molecular diagnostic tests. An effective cell-free urinary microRNA-based model was developed using a combined index of the levels of @entity4 and microRNA-125b to detect UCB with good discriminating power, high sensitivity and high specificity.

title: Cell-free urinary XXXX and microRNA-125b are diagnostic markers for the non-invasive screening of bladder cancer.

answer: @entity4


abstract: OBJECTIVE: To evaluate the national patterns of urologic follow up after @entity4 ( @entity4 ) and the occurrence and predictors of urological complications. MATERIALS AND METHODS: This retrospective cohort study used a 5% sample of Medicare data 2007-2010. The minimum adequate urologic surveillance was defined as a urologist visit, serum @entity2 evaluation, and upper urinary tract imaging study within the 2-year period. @entity0 were classified to their most severe complication in a multivariate linear regression model. RESULTS: Among the 7162 @entity0 with @entity4 , the majority were functionally paraplegic (82.4%) and Caucasian (80.9%). Among them, 4.9% received no screening studies over the 2-year period; 70.5% received some, but not all screening; and 24.6% received all three screening tests. @entity0 traveled a mean of 21.3    27.5 miles to receive care. A total of 35.7% of @entity0 saw a urologist during the 2-year period; 48.6% had some form of upper tract evaluation, with the majority being computed tomography scans; and 90.7% had serum @entity2 evaluation. Of all @entity0 , 35.8% had a minor complication during their 2-year follow up, 17.1% had a moderate complication, and 8.0% had a severe complication. In our prediction model, @entity0 factors that correlated with increased complications included male gender, African American race, @entity1 , and receiving some or all of the @entity3 recommended screening. @entity0 ' distance of travel to their treating physician (urologist or physiatrist) did not affect the rate of complications. CONCLUSION: Urological complications are common in @entity0 with @entity4 who receive Medicare. Most of these @entity0 with @entity4 are not receiving even the minimum recommended surveillance for these urological complications.

title: Urological Surveillance and Medical Complications after XXXX in the United States.

answer: @entity4


abstract: INTRODUCTION: @entity9 -like @entity4 (SPTL-AB) and @entity4 ( @entity4 ) are rare @entity4 with varying clinical courses. There is no standard treatment, although chemotherapy and hematopoietic stem cell transplantation are commonly used. We describe results using @entity8 for @entity0 and adults with these disorders. METHODS: We identified 15 @entity0 (12 adults, 3 @entity0 ) who were treated with @entity8 between 2000 and 2010 from the Memorial Sloan-Kettering @entity1 Center @entity3 database, the @entity1 Center Registry, and the National @entity1 Institute (NCI) @entity3 database. There were 8 females and 7 males, with a median age of 45 years (range, 3 years to 85 years). All @entity0 had stage IV disease. Two of 15 and 4 of 15 @entity0 had documented @entity4 and SPTL-AB, respectively; others were presumed to have SPTL-AB. @entity8 was administered at flat doses corresponding to 91 to 339 mg/m(2)/d. Two of 15 @entity0 received concurrent denileukin diftitox. Two @entity0 received @entity8 as maintenance therapy and were not evaluable for response. RESULTS: Among those treated with @entity8 alone, the overall response rate (ORR) was 82% (6/11 complete response [CR], 3/11 partial response [PR]). One of the 2 @entity0 treated with concomitant denileukin diftitox responded for an ORR of 10/13 (77%), including 54% CR and 23% PR. Median progression-free survival was 38.4 months; median duration of response was 26.3 months. Six @entity0 developed @entity5 and 9 developed @entity2 ; one @entity0 developed dose-limiting @entity7 . One pediatric @entity0 developed @entity6 . CONCLUSIONS: In this retrospective series, @entity8 showed a high response rate in SPTL-AB and @entity4 . It was generally well-tolerated with durable responses; therefore, @entity8 represents a promising therapy for @entity0 and adults with these disorders.

title: @entity8 is active against XXXX -like @entity4 in adult and pediatric populations.

answer: @entity9


abstract: UNASSIGNED: In @entity0 olfactory sensory neurons (OSNs) establish synapses with projection neurons (PNs) and local interneurons within @entity1 ( @entity1 ) glomeruli. Substantial knowledge regarding this circuitry has been obtained by functional studies, while ultrastructural evidence of synaptic contacts is scarce. To fill this gap we studied serial sections of three glomeruli using electron microscopy. Ectopic expression of a membrane-bound peroxidase allowed us to map synaptic sites along @entity3 dendrites. Our data proves for the first time that each of the three major types of @entity1 neurons is both pre- and postsynaptic to the other two types as previously indicated by functional studies. @entity3 dendrites carry a large proportion of output synapses, with approximately one output per every three input synapses. Detailed reconstructions of @entity3 dendrites showed that these synapses are distributed unevenly, with input and output sites partially segregated along a proximal-distal gradient and the thinnest branches carrying solely input synapses. Moreover, our data indicate synapse clustering as we found evidence of @entity2 . @entity3 output synapses exhibited T-shaped presynaptic densities, mostly arranged as tetrads. In contrast, output synapses from putative OSNs showed elongated presynaptic densities in which the T-bar platform was supported by several pedestals and contacted as many as 20 postsynaptic profiles. We also discovered synaptic contacts between the putative OSNs. The average synaptic density in the glomerular neuropil was about two synapses/  m(3) . These results are discussed with regard to current models of olfactory glomerular microcircuits across species. This article is protected by copyright. All rights reserved.

title: Synaptic circuitry of identified neurons in the XXXX of @entity0 .

answer: @entity1


abstract: OBJECTIVE: Changes to sexuality are a primary concern amongst @entity1 survivors, leading to @entity3 and impacting long-term quality of life. Effective sexual communication has been found to be critical in improving sexual satisfaction post-treatment. However, research suggests that many @entity0 struggle to disclose sexual concerns and preferences. This study aimed to qualitatively explore the common barriers and facilitators to sexual communication in male @entity1 survivors (MCSs). METHODS: Seventeen MCSs participated in semi-structured telephone interviews, which were transcribed and coded using Grounded Theory methodology. RESULTS: The emergent theory described that those MCSs with lower quality sexual communication experienced diminished perceived masculinity following @entity1 -related @entity2 . These feelings of inadequacy were compounded by inadequate partner support. Contrastingly, @entity0 reporting effective sexual communication expressed the importance of a stable self-esteem and flexible partner support. CONCLUSIONS: This study challenges the notion that @entity0 naturally struggle with intimate dyadic communication and suggests that adequate partner support and a stable sense of self can mitigate MCSs' communicative behaviour, subsequently bolstering self-esteem. Future research should more broadly explore the diverse experiences of MCSs to enhance the efficacy of psychosexual interventions. Copyright    2015 John Wiley _ Sons, Ltd.

title: Let's talk about sex after XXXX : exploring barriers and facilitators to sexual communication in male @entity1 survivors.

answer: @entity1


abstract: OBJECTIVE: The aim of the present study was to clarify the current work and sleep situations of physicians in Japan and to clarify the association between these situations and excessive @entity2 as well as medical incidents. METHODS: A self-administered questionnaire survey was conducted among the members of the Japan Medical Association in 2008. The randomly selected subjects comprised 3,000 male physicians and 1,500 female physicians. RESULTS: Valid responses were obtained from 3,486 physicians (2,298 @entity0 and 1,188 @entity0 ). Mean sleep duration was 6 h 36 min for @entity0 and 6 h 8 min for @entity0 . The prevalence of lack of rest due to @entity3 was 30.4% among @entity0 and 36.6% among @entity0 ; the prevalence of @entity1 was 21.0% and 18.1%, respectively; and the prevalence of @entity4 was 3.5%. The adjusted odds ratio for @entity4 was high for physicians who reported short sleep duration, lack of rest due to @entity3 , and a high frequency of on-call/overnight work. Physicians who had experienced a medical incident within the previous one month accounted for 19.0% of @entity0 . The adjusted odds ratio for medical incidents was high for those subjected to long working hours, high frequency of on-call/overnight works, lack of rest due to @entity3 , and @entity1 . CONCLUSION: In order to facilitate optimal health management for physicians as well as securing medical safety, it is important to fully consider the work and sleep situations of physicians.

title: Association of current work and sleep situations with excessive XXXX and medical incidents among Japanese physicians.

answer: @entity2


abstract: The measurement of the apparent diffusion coefficient (ADC) of water in brains of @entity2 @entity0 is used in models developed to help distinguish reversible from irreversible @entity1 . The ADC by conventional methods may be overestimated by the presence of cerebral spinal fluid (CSF) in sulci and perivascular spaces. In this study the hypothesis that DWI with CSF suppression (FLAIR-DWI) would result in different ADC values than those obtained with the conventional DWI technique was investigated. Thirty-one @entity0 with @entity2 onset of less than 6 hr and an acute lesion on conventional DWI were studied. Both conventional isotropic DWI and FLAIR-DWI were performed using a single-shot echo-planar technique. In all 31 @entity0 , CSF-suppressed ADC was lower than conventional ADC. The mean (SD) of the 31 @entity0 ' lesion ADC was 0.64 (0.08) x 10(-3) mm(2) s(-1) with FLAIR-DWI and 0.72 (0.09) x 10(-3) mm(2) s(-1) with conventional DWI (P < 0.001). The overestimation of ADC in conventional DWI corresponded to the percentage of the voxel that contained CSF. Suppression of CSF leads to lesion ADC values that are more homogeneous and more than 15% lower than those obtained with conventional DWI techniques. This suggests that FLAIR-DWI ADC measurements are more accurate than conventional ADC maps.

title: Cerebral spinal fluid contamination of the measurement of the apparent diffusion coefficient of water in acute XXXX .

answer: @entity2


abstract: OBJECTIVE: To investigate the longterm association of a wide range of comorbidities with physical and mental functioning in @entity0 with @entity4 ( @entity4 ). METHODS: Longitudinal data over a period of 11 years were collected from 882 @entity0 with @entity4 . Somatic comorbidity and comorbid @entity3 were measured at baseline, with a questionnaire including 20 @entity2 and with the Center for Epidemiologic @entity3 Scale, respectively. Physical functioning was measured at 5 timepoints with a disease-specific measure [Health Assessment Questionnaire (HAQ)] and a generic measure [physical scales of the Medical Outcomes Study Short Form-36 (SF-36)]. Mental functioning was measured with the mental scales of the SF-36. To determine the association of baseline-specific comorbidities with functioning over time, we performed longitudinal analyses. RESULTS: At baseline, 72% percent of the @entity0 were @entity0 , mean age    SD was 59.3    14.8 years, median @entity4 disease duration was 5.0 years, and 68% had >=  1 comorbid condition. The effect of comorbid conditions was more apparent when physical functioning was measured with SF-36, a disease-generic measure, compared with the HAQ, a disease-specific measure. Circulatory conditions and @entity3 were associated (p < 0.05) with worse physical functioning according to the HAQ. Respiratory conditions, musculoskeletal conditions, @entity1 , and @entity3 were associated (p < 0.05) with worse physical functioning according to the SF-36. Respiratory conditions and @entity3 were associated with worse mental functioning. CONCLUSION: @entity0 with specific comorbid conditions have an increased risk of low functioning in the long term. Targeted attention for these specific comorbid conditions by clinicians is recommended.

title: Physical and Mental Functioning in @entity0 with Established XXXX over an 11-year Followup Period: The Role of Specific Comorbidities.

answer: @entity4


abstract: OBJECTIVE: Overexpression of @entity5 is a mechanism of drug resistance in @entity1 . Agents that down-regulate @entity5 may decrease @entity1 cell threshold and sensitize @entity1 cells to chemotherapy. The objective of this multi-institutional phase 2 trial was to evaluate the efficacy and @entity2 of @entity6 and @entity5 modulators (13-cis @entity8 and interferon alfa-2b) in @entity0 with advanced-stage or recurrent @entity1 . MATERIALS AND METHODS: @entity0 had biopsy-proven metastatic, first relapse, or persistent @entity1 with no prior chemotherapy except for chemosensitizing agents. The treatment consisted of oral 13-cis @entity8 , 1 mg/kg, and subcutaneous interferon alfa-2b, 6 mU/m, days 1 to 4, and intravenous @entity6 , 175 mg/m, day 4 until disease progression or adverse events prohibited treatment. The primary endpoint was overall response rate. RESULTS: Thirty-three @entity0 were enrolled between March 2001 and June 2009. Thirty-one @entity0 were eligible for evaluation of treatment response. Twenty-seven @entity0 (82%) received prior concurrent chemoradiation or radiotherapy alone before study enrollment. The overall response rate was 30% (6 complete responses and 4 partial responses). Furthermore, 7 @entity0 (21%) had stable disease. Grade 3 or 4 adverse events included @entity7 (n =16 [48%]), @entity7 (n = 1 [3%]), and @entity4 (n = 1 [3%]). There were no treatment-related @entity3 . The median progression-free survival was 3.4 months (95% confidence interval, 2.0-7.4 months), and overall survival was 11.2 months (95% confidence interval, 7.5-26.2 months). Of 6 @entity0 with complete responses, 5 @entity0 survived more than 2 years. CONCLUSIONS: Combination therapy with @entity6 , 13-cis @entity8 , and interferon alfa-2b is feasible and safe in treating @entity0 with advanced and recurrent @entity1 .

title: Phase 2 Trial of @entity6 , 13-cis @entity8 , and Interferon Alfa-2b in the Treatment of Advanced Stage or Recurrent XXXX .

answer: @entity1


abstract: BACKGROUND: Laparoscopic surgery has been performed less frequently in the era of @entity2 due to technical difficulties and concerns about oncological safety. Radical antegrade modular pancreatosplenectomy (RAMPS) is expected to be helpful to obtain a negative margin during radical lymph node dissection. We hypothesized that it would also be favorable as a laparoscopic application due to unique features. METHODS: Fifteen laparoscopic RAMPS for well-selected @entity0 with left-sided @entity2 were performed from July 2011 to April 2016. Five trocars were usually used, and the operative procedures and range of dissection were similar to or the same as those of open RAMPS described by Strasberg. All medical records and follow-up data were reviewed and analyzed. RESULTS: All @entity0 had @entity3 . Mean operative time was 219.3        53.8  min, and estimated @entity1 was 250        70  ml. The length of postoperative hospital stay was 6.1        1.2  days, and postoperative morbidities developed in two @entity0 (13.3%) with urinary retention. The median number of retrieved lymph nodes was 18.1        6.2 and all had negative margins. Median follow-up time was 46.0  months, and the 3-year disease free survival and overall survival rates were 56.3% and 74.1%, respectively. CONCLUSION: Our early experience with laparoscopic RAMPS achieved feasible perioperative results accompanied by acceptable survival outcomes. Laparoscopic RAMPS could be a safe and oncologically feasible procedure in well-selected @entity0 with left-sided @entity2 .

title: Initial experience with laparoscopic radical antegrade modular XXXX in a single institution: technical aspects and oncological outcomes.

answer: @entity2


abstract: BACKGROUND: The main advantages of video assisted thoracoscopic surgery (VATS) include @entity1 , rapid recovery, less @entity2 , shorter hospital stay and early discharge. Although @entity1 intensity is less as compared to conventional thoracotomy but still @entity0 experience upto moderate @entity1 postoperatively. The objective of this study was to assess the efficacy and @entity4 sparing effect of @entity3 in alleviating immediate post-operative @entity1 in @entity0 undergoing VATS. MATERIALS AND METHODS: Sixty ASA I-III @entity0 , aged between 16 to 60 years, undergoing mediastinal lymph node biopsy through VATS under general anaesthesia were randomly divided into two groups. The @entity3 (ICNB group) received the block along with @entity0 control intravenous @entity5 (PCIA) with @entity4 , while control group received only PCIA with @entity4 for post-operative @entity5 . @entity0 were followed for twenty four hours post operatively for intervention of post-operative @entity1 in the recovery room and ward. RESULTS: The @entity1 was assessed using visual analogue scale (VAS) at 1, 6, 12 and 24 hours. There was a significant decrease in @entity1 score and @entity4 consumption in ICNB group as compared to control group in first 6 hours postoperatively. There was no significant difference in @entity1 scores and @entity4 consumption between the two groups after 6 hours. CONCLUSION: @entity0 receiving @entity3 have @entity1 control and less @entity4 consumption as compared to those @entity0 who did not receive @entity3 in early (6 hours) post-operative period.

title: Role of XXXX in reducing postoperative pain following video-assisted thoracoscopy: A randomized controlled trial.

answer: @entity3


abstract: BACKGROUND: The uncoupling protein @entity4 has been related to the development and/or maintenance of @entity2 through its involvement in regulating energy balance. The role of this mitochondrial protein in @entity0 is uncertain due to the scarce presence of the brown adipose tissue in the adult individual. The polymorphism @entity8 of the @entity4 alone or in conjunction with the mutation @entity7 of the adrenergic receptor b3 has been associated with @entity2 , @entity1 and related diseases although with contradictory results. With the aim of determining the influence of polymorphism @entity8 of the @entity4 on the classical components of the @entity3 in our population, we studied 159 @entity2 individuals and 154 of normal weight, with a study design of cases and controls. In all of them Body Mass Index (BMI), hip/waist index, % of body fat, @entity5 ( @entity5 ), lipidic profile, leptine, basal glucemia and @entity6 were determined. Similarly, the presence of the above mentioned mutation of the UCPI gene was analysed. RESULTS: Significant differences were obtained in all of the variables studied between @entity2 (cases) and normal weight (controls). Within the @entity2 group, polymorphism @entity8 of the @entity4 gene (n=53) was associated with a greater BMI (p=0.03), greater percentage of body fat (p=0.04) and higher @entity5 both systolic (p=0.009) and diastolic (p=0.02). There were no statistically significant differences in any of the other indices evaluated. CONCLUSION: The fundamental factor that influences the components of the @entity3 is @entity2 . However, the polymorphism @entity8 of the @entity4 gene is associated with a greater degree of @entity2 and very high figures of @entity5 .

title: [Influence of the polymorphism 03826 A --> G in the XXXX gene on the components of @entity3 ].

answer: @entity4


abstract: OBJECTIVE: The aim of this study was to assess the effects of aortic valve replacement (AVR) on the recovery of left ventricular function and the predictors for long-term survival in @entity0 suffering from isolated severe @entity5 ( @entity5 ) with a significant @entity7 ( @entity7 ). METHODS: This retrospective study was conducted on 46 @entity0 with isolated severe @entity5 and @entity7 [left ventricular ejection fraction (LVEF) = or < 40%] who underwent AVR in our clinic between January 1993 and March 2006. @entity0 with @entity4 , with more than moderate @entity3 (>2), with previous valve replacement or repair, and with other valve pathologies were excluded. The mean aortic valve area was 0.7+/- 0.09 cm2. The following fourteen variables were analyzed: etiology, age (= or >70 years), sex, preoperative New York Heart Association (NYHA) functional class, @entity8 , @entity2 , @entity1 , @entity9 , @entity6 , need for concomitant procedures for the ascending aorta, cardiopulmonary bypass time = or >120 min, aortic cross-clamp time = or >90 min, intraaortic balloon pump support and inotropic support. Statistical analysis for comparison of pre- and postoperative changes in clinical and functional variables was performed using Wilcoxon rank test. The predictors of early mortality after AVR were analyzed using logistic regression analysis and late survival was studied using Cox proportional regression and Kaplan Meier survival analyses. RESULTS: Operative mortality was 8.6% with four @entity0 . As the result of univariate logistic regression analysis, preoperative NYHA functional class = or >3 was found to be predictive of early mortality. @entity0 with NYHA class = or >3 had 12.6 times (OR: 12.6; 95%CI: 1.2-131.3; p=0.035) higher probability of early mortality than those with a lower NYHA class. However, multivariate logistic regression analysis demonstrated no predictor for early mortality. A positive change was observed in the LVEF in 79.3% of survivors and the mean LVEF increased from 34.5+/- 3.9% to 44.7+/- 10.4% (p<0.001). There were eight (19%) late deaths. Actuarial survival was 83. +/- 5.9% at 5 years and 59.6% +/- 10.9% at 10 years. Cox proportional hazards regression analysis demonstrated @entity1 (HR: 6.6; 95% CI: 1.19-36.9, p=0.031) and intraaortic balloon pump use (HR: 10.7; 95% CI: 2.9-39.7, p<0.001) as significant predictors for late mortality. CONCLUSION: Left ventricular ejection fraction and symptoms improve after AVR in @entity0 with isolated severe @entity5 and @entity7 with an acceptable operative mortality and satisfactory long-term survival.

title: Aortic valve replacement in isolated severe @entity5 with XXXX : long-term survival and ventricular recovery.

answer: @entity7


abstract: OBJECTIVE: To prospectively examine in pregnant @entity0 whether @entity4 or @entity4 therapy influenced @entity7 , intrauterine grown restriction (IUGR), or birthweight. METHODS: We enrolled 873 pregnant @entity0 with a history of @entity4 , of whom 778 experienced @entity4 symptoms or took medication, and 1333 @entity0 with no @entity4 history, including 884 @entity0 with neither @entity4 diagnosis nor symptoms and 449 with symptoms but no diagnosis. @entity5 , medication, and severity were classified according to 2002 Global Initiative for Asthma guidelines. RESULTS: Preterm delivery was not associated with @entity4 diagnosis, severity, or symptoms but was associated with use of controller medications, independent of symptoms, specifically oral @entity2 and @entity6 . Gestation was reduced by 2.22 weeks in @entity0 using oral @entity2 daily (P =.001) and 1.11 weeks after @entity6 (P =.002). We observed a 24% (5-47%) increased risk for IUGR with each increased symptom step, which increased further in symptomatic @entity0 with no @entity4 diagnosis (31%, 4-65%) compared with @entity0 with neither @entity4 nor symptoms. CONCLUSIONS: We found no effect of @entity4 symptoms or severity on @entity7 but observed increased risks associated with use of oral @entity1 and @entity6 . Intrauterine growth restriction was associated with @entity4 severity, which possibly reflects a @entity3 fetal effect. @entity0 with @entity4 symptoms but no diagnosis were at particular risk of undermedication and delivering IUGR @entity0 . These observations support guidelines that advocate active management of pregnant @entity0 with mild or moderate @entity4 with beta(2) agonists, with oral @entity2 added only if severity increases. Symptomatic @entity0 without an @entity4 diagnosis might need to be equally managed.

title: XXXX , severity, and drug therapy: a prospective study of effects on 2205 pregnancies.

answer: @entity5


abstract: The enrichment of @entity2 ( @entity4 ) and @entity1 ( @entity0 ) in the sea-surface micro-layer and depth profile of these pollutants in the water column were investigated at Gerlache Inlet, Terra Nova Bay, Antarctica. Depth profile samplings were repeated three times during the Antarctic summer (from November to February). @entity2 and @entity1 showed a concentration range in the water column of 30-120 pg l(-1) and 150-400 pg l(-1), respectively, and these values were very much dependent on the suspended matter content. A nearly two-fold decrease in the pollutant concentration was also observed in the depth profile obtained in February, i.e. late summer, which might be correlated both with the high content of suspended matter and the reduction of the pollutant input. Moreover, isomer ratios of @entity1 , such as LMW/HMW and @entity3 , highlight that the main @entity1 source might be petrogenic in nature, whereas the pyrolytic source seems to be less important. Sea surface micro-layer (SML) and sub-surface sea water (SSW) samples were simultaneously collected in the same site by a remote controlled rotating drum-based sampling system, a prototype named MUMS (Multi-User Micro-layer Sampler). Sea surface micro-layer samples showed a total content of @entity2 and @entity1 in the range 400-450 pg l(-1) and 2000-3000 pg l(-1), respectively, whereas the mean content of the sub-surface sea water samples was 48 pg l(-1) and 325 pg l(-1), respectively. The mean enrichment factors of @entity2 and @entity1 in sea-surface micro-layer were about 10 and 7, respectively. The surface excess concentrations of @entity2 and @entity1 were about 35 000 and 200 000, respectively. A fairly good correlation was observed between the concentration of pollutants and water solubility. Based on the assumption that POPs are confined in a very thin top layer of the SML about 0.01-0.001 microm thick, namely the sea-surface nano-layer, and also on an estimated thickness of the sampled sea-surface layer of about 100 microm, an enrichment factor of 10(5)-10(6) for the sea-surface nano-layer was calculated. Such a very high concentration increase was related to the two-fold increase of @entity1 concentration observed in the underlying 20 cm of the water column in late summer.

title: @entity4 and XXXX in the sea-surface micro-layer and the water column at Gerlache Inlet, Antarctica.

answer: @entity0


abstract: BACKGROUND: Worldwide, millions of @entity0 are treated each year for significant @entity5 . A substantial proportion die, and many more are disabled. If short term corticosteroid infusion could be reliably shown to reduce these risks by just a few percent then this might affect the treatment of a few hundred thousand @entity0 a year, protecting thousands from @entity3 or long term disability. STUDY DESIGN: @entity7 is a large simple, placebo-controlled trial of the effects of a 48-hour infusion of @entity4 on @entity3 and on @entity1 , among adults with @entity5 and some @entity6 . Head injured @entity0 with @entity6 who are judged to be 16 years or older are eligible if the responsible doctor is, for any reason, substantially uncertain whether or not to use @entity4 . ORGANISATION: The @entity7 trial will determine reliably the effects on @entity3 and disability of a short corticosteroid infusion following significant @entity5 . To detect or refute improvements of only a few percent in outcome, many thousands of acute @entity5 @entity0 must be randomised between control and @entity2 infusions. Such large numbers will be possible only if hundreds of doctors and nurses can collaborate in the participating emergency departments. Since they are busy, and working in emergency situations, the trial involves them in almost no extra work: no special investigations or changes to usual management are required, and data collection is absolutely minimal. The trial is on-going and new collaborators are welcome. Further information about the trial is available at http://www. @entity7 .lshtm.ac.uk

title: The @entity7 trial protocol (Corticosteroid randomisation after significant XXXX ) [ISRCTN74459797].

answer: @entity5


abstract: BACKGROUND: @entity6 ( @entity6 ) can be a debilitating side effect of opioid therapy and may result in increased medical costs. The published data on the economic burden of @entity6 among long-term opioid users are limited. OBJECTIVE: To assess the economic burden of @entity6 in @entity0 with noncancer @entity2 in a managed care population in the United States. METHODS: This retrospective study used 2007-2011 data from the Truven Health MarketScan Commercial and Medicare databases. The study included adults with >= 12 months of insurance enrollment before and after starting long-term (>= 90 days) use of opioids. @entity0 were excluded if they had @entity1 or a diagnosis of @entity3 or drug dependence during the study period, or if they had @entity4 or @entity5 within 90 days before starting opioid therapy during the study period. @entity6 was identified by International Classification of Diseases, Ninth Edition codes for @entity4 (564.0) or @entity5 (560.x) within 12 months of the initiation of an opioid. @entity0 with @entity6 were identified in the nonelderly, elderly (age >= 65 years), and long-term care populations. Differences in costs and healthcare resource utilization were calculated using propensity scoring. RESULTS: A total of 13,808 nonelderly (age, 48.6    10.4 years; female, 50%) and 2958 elderly @entity0 (age, 78.7    8.1 years; female, 70%) met the study inclusion criteria. Of 401 nonelderly and 194 elderly @entity0 with @entity6 , 85 @entity0 initiated opioid therapy in a long-term care facility (age, 80.7    11.6 years; female, 77%). After matching by key covariates, @entity0 with @entity6 had significantly more hospital admissions than @entity0 without @entity6 (nonelderly, 33% vs 22%, respectively; P <.001; elderly, 51% vs 31%, respectively; P <.001) and longer inpatient stays (nonelderly, 3.0    8.4 days vs 1.0    3.0 days, respectively; P <.001; elderly, 5.2    12.2 days vs 2.1    4.0 days, respectively; P <.001). The group with @entity6 had significantly higher total healthcare costs than the group without @entity6 in all 3 study cohorts (nonelderly,  23,631     67,209 vs  12,652     19,717, respectively; elderly,  16,923     38,191 vs  11,117     19,525, respectively; long-term care,  16,000     22,897 vs  14,437     25,690, respectively; all P <.05). CONCLUSION: To the best of our knowledge, this is the first study to analyze the economic impact of long-term use of opioids among @entity0 with @entity6 , using real-world data. The findings underscore the significant economic burden associated with long-term opioid use for noncancer @entity2 in a managed care population. Effective therapies for @entity6 may reduce the associated economic burden and improve quality of life for long-term opioid users.

title: Economic burden of opioid-induced XXXX among long-term opioid users with noncancer @entity2 .

answer: @entity4


abstract: A new cell line, designated UHKBR-01, was successfully established from a @entity8 ( @entity4 )-induced @entity3 mammary @entity1 . @entity4 was administered orally at a dose of 4 mg/ml per @entity3 on the first day of the experiment and thereafter at weekly intervals of same dosage, until the @entity3 have reached a weight of around 150-200 g. The @entity1 grew rapidly after the injection, and were transplanted into @entity2 one the harvest size (2.5 x 2 x 1 mm(3)) was reached, it was transplanted onto @entity2 . We have developed a cell line from a portion of the @entity4 -induced @entity5 of the @entity2 . The UHKBR-01 cell exhibited a slow increase in growth rate during the time of culture and was highly tumourigenic in @entity2 . The cells have been grown in culture for over 40 passages. Characterization of the cell line was performed. This included morphology by light and transmission electron microscopy, karyotype, growth rate, @entity1 antigen expression and xenograft implantation into @entity2 . These cells exhibit ultrastructural and immunohistochemical features of epithelial cells of mammary origin. The above analyses also demonstrated that UHKBR-01 cells were @entity7 - and @entity6 -receptor positive, in likeness to other @entity0 cell lines such as MDA-MB-231 and MCF-7. The cell line grows as monolayers of oval-shaped cells with large folded nuclei accompanied by a rich supply of mitochondria. This report describes the first in vitro cell line from transplantable @entity4 -induced @entity5 of @entity2 , which presents unique characteristics that may prove to be a good experimental model for investigating @entity0 biology.

title: A @entity3 cell line derived from @entity4 -induced XXXX .

answer: @entity5


abstract: The aim of the present work was to evaluate the number of apoptotic eosinophils in the livers of @entity3 experimentally infected with @entity5 during the @entity4 . Four groups (n=5) of @entity3 were used; groups 1-3 were orally infected with 200 metacercariae (mc) and sacrificed at 8 and 28 days post-infection (dpi), and 17 weeks post-infection (wpi), respectively. Group 4 was used as an uninfected control. Apoptosis was detected using immunohistochemistry with a polyclonal antibody against anti-active @entity6 , and transmission electron microscopy (TEM). Eosinophils were identified using the Hansel stain in serial sections for @entity6 , and by ultrastructural features using TEM. At 8 and 28 dpi, numerous @entity6 (+) eosinophils were mainly found at the periphery of acute hepatic @entity0 foci. The percentage of @entity6 (+) apoptotic eosinophils in the periphery of @entity0 foci was high (46.1-53.9) at 8 and 28 dpi, respectively, and decreased in @entity2 found at 28 dpi (6%). Transmission electron microscopy confirmed the presence of apoptotic eosinophils in @entity1 at 8 and 28 dpi. At 17 wpi, apoptotic eosinophils were detected in the infiltrate surrounding some enlarged bile ducts containing adult flukes. This is the first report of apoptosis induced by @entity5 in @entity3 and the first study reporting apoptosis in eosinophils in hepatic inflammatory infiltrates in vivo. The high number of apoptotic eosinophils in acute @entity0 tracts during the @entity4 suggests that eosinophil apoptosis may play a role in @entity5 survival during different stages of infection.

title: @entity5 induces eosinophil apoptosis in the XXXX in @entity3 .

answer: @entity4


abstract: BACKGROUND: @entity5 are rare glioneuronal @entity1 that typically cause refractory @entity3 during the first 3 decades of life. OBJECTIVE: To determine the prognosticators of @entity3 outcome after surgery for @entity5 . METHODS: We reviewed the cases of 66 @entity0 who underwent resection of @entity5 at the University of California, San Francisco. Demographic, @entity3 history, and operative data were examined for statistical association with postoperative @entity3 outcomes. RESULTS: Of the 66 @entity0 who underwent surgical resection of @entity5 , 49 @entity0 (74%) presented with a history of @entity3 . Of those 49 @entity0 , 50% presented with intractable @entity2 . @entity4 were present in 76% of the @entity0 who presented with a history of @entity3 . Electrocorticography was performed on 35% of the @entity0 , and of those @entity0 , 82% underwent extended lesionectomy to remove abnormally epileptogenic extralesional tissue. The median follow-up duration was 6.9 years, during which @entity1 progression occurred in 38% of @entity0 who underwent subtotal resection and in 8% of @entity0 who underwent gross total resection (P = .02). Overall, 85% of @entity0 were @entity3 free (International League Against @entity2 class I or II) 5 years after surgery. Subtotal resection was associated with poor @entity3 outcomes 1 year after resection (odds ratio = 14.6; 95% confidence interval = 2.4-87.7): rates of @entity3 freedom were 54% after subtotal resection, 96% after gross total resection, and 93% after gross total resection with intraoperative electrocorticography-guided extended lesionectomy. CONCLUSION: We report excellent long-term @entity3 control outcomes after surgery for @entity5 . Intraoperative electrocorticography may be a useful adjunct for guiding extended resection in certain pharmacoresistant @entity2 @entity0 with @entity5 . Subtotal resection is associated with higher rates of @entity1 progression and nonoptimal @entity3 outcomes.

title: Long-term @entity3 control outcomes after resection of XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity2 ( @entity2 ) is a rare @entity1 that might occur in nasal cavity and paranasal sinuses. It is characteristic for poor prognosis, especially the solid histopathological subtype of the @entity1 . @entity2 might spread along nerves and fascias and it is usually diagnosed at advanced stage. Computed tomography and magnetic resonance imaging together with fine-needle biopsy are the gold standards in the diagnostic procedure of the @entity1 . Surgery with adjuvant therapy are the most common methods of treatment. Among the surgical approaches, the functional endonasal sinus surgery seems to be the most appropriate and favorable way of treatment. In the study, the authors present a case of a 62-year-old @entity0 with T4aN0M0 @entity1 treated endoscopically at the Department of Laryngology and ENT Oncology, @entity3 No. 5 in Sosnowiec. The authors indicate the usefulness of FESS procedure in the treatment of @entity1 and paranasal sinuses. They also review the recent publications on endonasal versus open approach in similar cases. In conclusions, the authors favor endonasal approach as a mini-invasive method of surgical treatment of @entity2 of paranasal sinuses that results in satisfactory oncological outcome and high quality of @entity0 's life.

title: Endoscopic approach to the resection of XXXX of paranasal sinuses and nasal cavity: case report and own experience.

answer: @entity2


abstract: BACKGROUND: @entity15 is a @entity4 that causes @entity7 . It is characterized by the fibrotic thickening of the endocardium, sometimes involving the myocardium as well. The lesion generally lies at the apices or inflow tracts of one or both ventricles, associated with more or less severe alteration of the valves. It is a disease of the intertropical regions but is not well known in Cameroon. In this study we describe the first series seen in a pediatric hospital in Cameroon. @entity0 AND METHODS: A retrospective study was conducted in a pediatric hospital in Yaound   involving @entity0 who had been diagnosed with @entity15 after echocardiographic investigation. We collected the clinical and paraclinical data from consultation records and medical files. RESULTS: Between January 2006  to December 2013, we registered 1430 @entity0 with a @entity5 in our center. @entity15 was found in 46 @entity0 . Neither sex predominated. Ages at the time of diagnosis varied between 2  and 17years. Most of the @entity0 were between 5  and 15years old (80.4  %), with a median of 10years (interquartile range, 7-13years). The main complaints were @entity12 , cough, abdominal distension, abdominal, and @entity11 . Apart from the @entity14 of the lips observed in all our @entity0 , @entity12 was the most frequent physical sign and the diagnosis was made at a time when signs of @entity7 were preponderant. @entity9 was found in all the @entity0 examined. All @entity0 were underweight with a median weight for age found below the 25th percentile of the norms according to the National Health Statistics. Lower limb @entity1 was absent even in the presence of @entity8 . All subjects had hyperpigmented lips. Despite the cyanotic appearance of the lips, pulse oximetry always gave a normal @entity2 saturation level and no cyanosis was seen elsewhere. None of the @entity0 had nail clubbing. @entity3 more often affected the right ventricle (45/46 @entity0 ). The apical obliteration by fibrotic material was found in 43 (93.5  %) @entity0 . Moreover, 36 (78.3  %) @entity0 had pericardial effusion: mild to moderate in 32subjects and abundant in four subjects. @entity13 was noted in 57.5  % of the @entity0 . @entity10 was found in six out of 15 @entity0 who had an electrocardiogram done. CONCLUSION: The modes of clinical presentation of @entity15 are not sufficiently well known in our context. Despite its insidious progression, certain signs such as @entity6 and hyperpigmented lips could be very helpful for screening and easing orientation of parents and heath personnel, thus enabling early referral for appropriate investigation. The presence of bulky @entity8 without @entity1 of the lower extremities should be viewed as strongly suggestive.

title: [ XXXX in Cameroon: Echocardiographic and clinical description of a pediatric series in Yaound  ].

answer: @entity15


abstract: Many xenobiotics are known to cause @entity2 and hepatocarcinogenesis in @entity1 , although the molecular mechanisms that underlie this effect remain largely undefined. @entity0 exposure to several of these compounds, including glucocorticoids and peroxisome proliferators may be significant, due to their use in both pharmaceutical and industrial processes. It is therefore important to elucidate the molecular mechanisms underlying this abnormal @entity2 in @entity1 , as this will enable more accurate extrapolation of the possible outcomes of @entity0 exposure. Male @entity1 were dosed with the peroxisome proliferator @entity5 and changes in liver gene expression examined using subtractive suppression hybridisation examined either 12 of 24hr later. Twenty-five transcripts were identified which showed differential gene expression in liver following exposure to @entity5 . Biochemical indices of liver growth (DNA synthesis, apoptosis) showed that these changes correlated with the @entity2 . @entity1 were next treated with either @entity5 , @entity4 and @entity3 , chemically and mechanistically-distinct hepatomegalic compounds. Carboxylesterase and @entity6 mRNA levels were seen to alter in a qualitatively similar fashion for all three compounds, and in a liver specific fashion. In addition, these changes correlated with a decrease in the density of Kupffer cells within the liver, which are known to release mitogenic cytokines, and have been linked to @entity5 -induced cell proliferation. We therefore propose that Kupffer cells play a role in a general mechanism of @entity2 .

title: Gene expression changes in XXXX liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.

answer: @entity1


abstract: UNASSIGNED: @entity3 is an important industrial fungus expressing a broad spectrum of pectinolytic genes. The main constituent of pectin, @entity5 ( @entity2 ), is degraded into @entity6 (GA) by the combined activity of endo- and exo-polygalacturonases some of which are specifically induced by GA. The regulatory mechanisms that control the expression of genes encoding @entity2 -degrading enzymes are not well understood. Based on available genome-wide expression profiles from literature, we selected five genes that were specifically induced by GA. These genes include three exo-polygalacturonases (pgaX, pgxB and pgxC), a GA transporter (gatA), and an intracellular enzyme involved in GA metabolism (gaaB). These five genes contain a conserved motif (5'-TCCNCCAAT-3') in their promoter regions, which we named GARE ( @entity6 -responsive element). Promoter deletion studies and site-directed mutagenesis of the conserved motif of the pgaX gene showed that the conserved element is required for GA-mediated induction. A set of promoter reporter strains was constructed by fusing the promoter region of the five above-mentioned genes to the amdS reporter gene. Expression of the amdS gene is quantitatively correlated with ability to utilise @entity4 as an N-source, hence higher expression of amdS improves growth of the strain on @entity4 and therefore can be used as an in vivo reporter for gene expression. Growth analysis of the reporter strains indicated that four genes (pgaX, pgxB, pgxC, and gatA) are specifically induced by GA. The in vivo promoter reporter strains were also used to monitor @entity1 catabolite repression control. Except for gaaB, all promoter-reporter genes analysed were repressed by @entity0 in a @entity0 concentration-dependent way. Interestingly, the strength of @entity0 repression was different for the tested promoters. CreA is important in mediating @entity1 catabolite repression as deletion of the creA gene in the reporter strains abolished @entity1 catabolite repression for most promoters. Interestingly, the pgxC promoter was still repressed by @entity0 even in the creA null background, suggesting a role for alternative repression mechanisms. Finally, we showed that low concentrations of GA are required to induce gene expression of pgaX, pgxB, and pgxC even under derepressing conditions. The results obtained are consistent with a model in which a GA-specific transcription factor is activated by GA or a GA-derivative, which binds to the conserved motif, possibly in combination with the HAP-complex, to drive GA-specific gene expression.

title: The interaction of induction and repression mechanisms in the regulation of @entity6 -induced genes in XXXX .

answer: @entity3


abstract: BACKGROUND: Ipilimumab has been shown to improve overall survival in @entity0 with @entity2 ; however, complete responses (CRs) are uncommon. Immune-related side effects usually involve the skin or gastrointestinal tract. Neurologic events occur less frequently but are well described. CASE REPORT: We report the case of a 58-year-old @entity0 with @entity2 who commenced ipilimumab post spinal decompression and radiation. He developed a colitis post cycle 2 and ipilimumab was discontinued. Imaging, however, documented a radiological CR. 8 weeks later, he developed @entity3 and a @entity4 despite an ongoing radiological CR. @entity1 use resulted in some improvement radiologically, without clinical improvement. CONCLUSION: We report @entity4 with consequent @entity3 as a potential neurological immune-related side effect of ipilimumab. We further describe a @entity0 with a CR after 2 cycles of ipilimumab in the setting of radiation.    2014 S. Karger GmbH, Freiburg.

title: Late-onset XXXX after complete response to two cycles of ipilimumab for @entity2 .

answer: @entity3


abstract: BACKGROUND/AIM: The purpose of this study was to determine the epidemiological and clinical characteristics of @entity0 diagnosed with @entity6 and the effectiveness of the administered treatments. MATERIALS AND METHODS: @entity0 treated in our hospital between January 2009 and March 2011 and diagnosed with @entity6 were evaluated retrospectively. @entity0 ' epidemiological and clinical characteristics, administered treatments, and posttreatment findings were recorded on @entity0 monitoring forms. RESULTS: At anamnesis, 29% of @entity0 used water from wells and 71% used water from the network supply; moreover, 48.4% had a history of contact with animals and 87.1% a history of lethargy. At physical examination, 96.8% had a mass in the neck and 90.3% had @entity1 . @entity2 + @entity3 therapy was administered to 45.2% of @entity0 , while @entity5 , @entity2 , and @entity4 were used for the other @entity0 . After treatment, neck masses persisted in 48.4% of @entity0 and complaints of lethargy and @entity1 in 6.5%. Treatment of these @entity0 was initiated once @entity6 had been diagnosed, as test results were announced about 3 weeks later. Lymphadenopathy excision was performed on 19.4% of @entity0 in whom neck mass persisted. CONCLUSION: Appropriate empiric antibiotherapy should be commenced in @entity0 presenting with neck mass, @entity1 , and lethargy in regions with @entity6 epidemics.

title: Epidemiological and clinical characteristics and management of XXXX outbreak.

answer: @entity6


abstract: PURPOSE: Polypoid @entity2 (PA) is an uncommon @entity0 appearing as a submucosal polypoid mass, or rarely as a subserosal polypoid mass. PA should be differentiated from @entity2 or malignant uterine @entity0 . The purpose of our case series is to evaluate magnetic resonance (MR) manifestations of PA for the differential diagnosis. METHODS: Seven cases with surgically proven PA, five submucosal, and two subserosal, were evaluated. MR imaging findings including contrast enhancement in six cases (four cases with dynamic contrast-enhanced MR study), @entity1 ( @entity1 ) in five cases, and susceptibility weighted imaging (SWI) in two cases were retrospectively reviewed. RESULTS: All seven lesions exhibited isointensity compared with the myometrium and 4 of 7 lesions (57%) contained high signal intensity hemorrhagic areas on T1-weighted images. On T2-weighted images, signal intensity was variable and all seven lesions contained cysts. None of five lesions with @entity1 exhibited high signal intensity compared with the normal myometrium. All six lesions showed intense contrast enhancement similar to that of the myometrium on post-contrast T1-weighted images. Punctate low intensity areas reflecting blood contents were revealed in all two lesions with SWI. CONCLUSIONS: Submucosal or subserosal polypoid masses containing hemorrhagic areas, and cysts reflecting functional endometrium and dilatation of endometrial glands are suggestive for PA. Intense contrast enhancement similar to that of the myometrium may be another characteristic finding for PA.

title: MR manifestations of uterine polypoid XXXX .

answer: @entity2


abstract: Serum @entity3 ( @entity3 ) is sometimes high in @entity0 with primary @entity4 , and there is no comprehensive study on the clinicopathologic characteristics and prognostic factors of @entity3 -producing @entity4 (AGC). To clarify the variables associated with the survival after gastrectomy for AGC, we reviewed the data of @entity0 with AGC and examined the independent prognostic factors. We studied 270 cases of AGC reported in the Japanese literature from June 1982 to March 2001, together with 1 @entity0 of our own experience. The clinicopathologic findings, including serum @entity3 level, operative curability, and stage of the disease were examined, and factors associated with survival were determined by multivariate analysis. There were 15 stage I @entity2 (6%), 50 @entity2 (19%), 51 @entity2 (20%), and 145 stage IV @entity2 (55%). The @entity2 were characterized by frequent serosal invasion (75%), lymph node @entity1 (83%), liver @entity1 (33%), @entity2 (75%), and noncurative operation (48%). The survival was influenced by the serum @entity3 level, @entity2 size, serosal invasion, lymph node @entity1 , and liver @entity1 , but the independent prognostic factors were operative curability (curative vs. noncurative) and stage of the disease (I, II vs. III, IV). Although the 5-year survival rate and median survival period in all @entity0 were 22% and 14 months, respectively, those in @entity0 with curative gastrectomy were 42% and 29 months, respectively. The results indicate that operative curability and stage of the disease are factors associated with the survival of @entity0 with AGC. Although @entity2 are often advanced and complicated with liver metastases, long-term survival can be achieved when @entity0 with stage I or II @entity2 undergo curative gastrectomy.

title: @entity3 -producing @entity4 : multivariate analysis of prognostic factors in 270 XXXX .

answer: @entity0


abstract: We report a case of chronic active @entity5 (CAEBV) associated with skin @entity3 mimicking @entity7 ( @entity7 ) in a 4-year-old @entity0 . The @entity0 had repeated episodes of @entity1 on the face, scalp, and bilateral forearms one year before the first visit to our department. General symptoms including fever, @entity4 , and cervical lymph node swelling were noted three months before the first visit. At the first visit, small, bean-sized, erythemic papules with central @entity1 were observed on the face and anterior chest wall. Thumb-sized ulcers with crust were present on the bilateral forearms. Histopathological examination of an @entity2 in the submandibular area revealed @entity6 with a thick crust, mild spongiosis in the epidermis, and a dense infiltration of lymphoid cells into the dermis and perivascular space. Laboratory examination showed EBNA x 40, EBV VCA IgG x 1,280, and EBV DNA (PCR) 8 x 10(4). EBV-encoded small nuclear RNA (EBER) positive cells were detected in the dermis by an in situ hybridization (ISH) method. Large granular lymphocytes (65%) with the NK cell phenotype were found in the peripheral blood. A real time PCR method showed 171,741 copies/ micro g DNA in CD 16 positive cells. Although latent EBV infection-associated @entity3 have been documented, detailed skin manifestations in CAEBV are less well known.

title: XXXX in a @entity0 with @entity5 .

answer: @entity7


abstract: Precise regulation of hepatic @entity1 (TG) metabolism and secretion is critical for health and exercise could play a significant role. We compared one session of high-intensity interval exercise (HIIE) vs. continuous exercise (CE) on hepatic TG metabolism. Female and male @entity0 were assigned to CE, HIIE, or sedentary control (CON). HIIE was a 30min session of 30s running intervals (30m/min) interspersed with 60s walking periods (5m/min). CE was a distance- and duration-matched run at 13.8m/min. Hepatic content of TG and TG secretion rates, as well as expression of relevant genes/proteins, were measured at 3 hr (Day 1) and 28 hr (Day 2) post-exercise. On Day 1, hepatic [TG] in CE and HIIE were both elevated vs. CON in both sexes with ~2-fold greater elevation in HIIE vs. CE in females. In both sexes, hepatic @entity2 ( @entity2 ) protein on Day 1 was increased significantly by both exercise types with a significantly greater increase with HIIE than CE, while the increase in mRNA reached significance only after HIIE. On Day 2 in both sexes the increases in hepatic TG and @entity2 with exercise declined toward CON levels. Only HIIE on Day 2 resulted in reduced hepatic TG secretion by ~20% in females with no effect in males. Neither exercise modality altered AMPK signaling or microsomal @entity1 transfer protein expression. Females exhibited higher hepatic TG secretion than males in association with different expression levels of related metabolic enzymes. These intensity-dependent and sex-specific alterations following exercise may have implications for sex-based exercise prescription.

title: Intensity-dependent and sex-specific alterations in hepatic @entity1 metabolism in XXXX following acute exercise.

answer: @entity0


abstract: UNASSIGNED: There is a need to develop new, more efficient therapies for @entity2 ( @entity3 ) @entity0 . It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. @entity6 inhibitors (PARPi) were found to be "synthetic lethal" in @entity1 in @entity5 /2 with impaired homologous recombination. Since @entity1 rarely have these particular mutations, there is considerable interest in finding alternative determinants of PARPi sensitivity. Effectiveness of combined irradiation and PARPi olaparib was evaluated in ten @entity3 cell lines, subdivided into HR-proficient and @entity4 cell lines using a GFP-based reporter assay. Both groups were equally sensitive to PARPi alone. Combined treatment revealed stronger synergistic interactions in the @entity4 group. Because HR is mainly active in S-Phase, replication processes were analyzed. A stronger impact of treatment on replication processes (p = 0.04) and an increased number of radial chromosomes (p = 0.003) were observed in the @entity4 group. We could show that radiosensitization by inhibition of @entity6 strongly correlates with HR competence in a replication-dependent manner. Our observations indicate that @entity6 inhibitors are promising candidates for enhancing the therapeutic ratio achieved by radiotherapy via disabling DNA replication processes in @entity4 HNSCCs.

title: XXXX inhibition radiosensitizes @entity3 in homologous recombination by disabling the DNA replication fork elongation response.

answer: @entity6


abstract: BACKGROUND: Discrepancies in the clinicopathologic parameters pre- and post-endoscopic submucosal dissection (ESD) sometimes necessitate additional surgical resection. The aim of this study was to assess such discrepancies in clinicopathologic parameters before and after ESD in the context of reducing the risk of failure of curative ESD. METHODS: Data on 712 early @entity4 @entity0 were prospectively collected from 12 university hospitals nationwide. The inclusion criteria were differentiated @entity3 <3  cm in size, no @entity5 , @entity1 <500   m, and no @entity1 . Clinicopathologic factors were compared retrospectively. RESULTS: The discrepancy rate was 20.1  % (148/737) and the most common cause of discrepancy was @entity2 size (64 cases, 8.7  %). Ulceration, undifferentiated histology, and @entity6 invasion were found in 34 (4.6  %), 18 (2.4  %), and 51 cases (6.9  %), respectively. Lymphovascular invasion (LVI) was observed in 34 cases (4.6  %). Cases with lesions exceeding 3  cm in size showed more frequent @entity1 , an elevated gross morphology, and upper and middle locations (p  <  0.05). In the cases with @entity5 , depth of invasion (DOI) was deeper than in the cases without @entity5 (p  =  0.005). Differentiation was correlated with DOI and LVI (p  =  0.021 and 0.007). DOI was correlated with @entity2 size, @entity5 , differentiation, LVI, gross type, and location. There were statistically significant differences between mucosal @entity2 cases and @entity2 cases in @entity2 size, differentiation, @entity5 , LVI, and location. CONCLUSIONS: The overall discrepancy rate was 20.1  %. To reduce this rate, it is necessary to evaluate the DOI very cautiously, because it is correlated with other parameters. In particular, careful checking for SM-invasive @entity2 is required due to the high incidence of LVI irrespective of the depth of @entity1 .

title: Pre- and post-ESD discrepancies in clinicopathologic criteria in early @entity4 : the NECA-Korea ESD for Early XXXX Prospective Study (N-Keep).

answer: @entity4


abstract: Published literature on the @entity1 of a @entity9 @entity7 is limited to case reports. This retrospective study of poison center data was performed to examine the severity of @entity9 @entity7 . Data on single substance exposures to @entity9 reported to the American Association of Poison Control Centers (AAPCC) Toxic Exposure Surveillance System (TESS) in 2000 and 2001 were retrospectively analysed. A total of 567 cases met the inclusion criteria, of which 39% occurred in adults over 19 years of age and 30.2% in @entity0 < or = 4 years old. The majority of @entity0 (62.1%) experienced no @entity1 . The most common clinical effects reported were drowsiness/lethargy (15.5%), dizziness/vertigo (4.9%), @entity10 (4.9%), @entity6 (3.9%), @entity3 (2.6%) and @entity4 (2.5%). Symptomatic @entity0 were older than asymptomatic @entity0 and adults were more likely to be managed in a healthcare facility (P <0.0001). @entity0 who received gastrointestinal decontamination experienced less serious outcomes than those without decontamination (P <0.02). It is concluded that clinicians should expect relatively mild mental status changes in adults or @entity0 with @entity1 from @entity9 @entity7 . Serious toxic effects, such as @entity2 with @entity8 or persistent non-anion gap @entity5 , are infrequent.

title: Evaluation of @entity1 of XXXX exposures reported to poison centers.

answer: @entity9


abstract: UNASSIGNED: Extra-cranial carotid @entity2 (ECAA) are uncommon and represent a therapeutic challenge for clinicians. An ECAA is generally defined as a @entity5 (CCA) greater than 150% of the diameter of the normal healthy artery. The presence of an ECAA is usually found by coincidence in asymptomatic @entity0 . Symptomatic @entity0 may present with @entity1 or symptoms of local compression. The initial diagnosis of ECAA is often by echo/duplex ultrasound imaging. However, Computerized tomographic angiography (CTA), with 3- dimensional reconstruction of the images (3D) can provide additional and valuable information, especially when considering surgical exclusion of the @entity3 . Recently, vessel wall imaging using contrast enhanced Magnetic Resonance with @entity4 administration was explored, which could potentially provide valuable information regarding @entity3 wall changes during clinical follow up. Location and accessibility of an ECAA is key information when considering the appropriate treatment. With the lack of evidence based treatment guidelines, a conservative approach with or without medicinal treatment is currently the standard of care for asymptomatic non-growing ECAA. Open surgical repair has for long been the accepted treatment for @entity0 with a growing @entity3 or @entity3 related symptoms. Endovascular interventions are increasingly applied, especially when surgical intervention is considered too risky or not possible due to @entity0 comorbidities or anatomical restrictions. Data on the natural course, immediate and long-term results of surgical or endovascular therapy is scarce. Thus, there is a clear need for an international collaboration collecting data of ECAA within a registry.

title: Which carotid XXXX need to be treated (and how)?

answer: @entity2


abstract: BACKGROUND: The disease burden is increasing for @entity2 ( @entity2 ) due to increasing of the growth rate of prevalence and mortality. But the empirical researches are a little for @entity2 that studied the association between continuity of care and death and about predictors effect on mortality. OBJECTIVE: To investigate the association between continuity of care (COC) and @entity2 ( @entity2 ) mortality and to identify other mortality-related factors in @entity2 @entity0 . METHODS: We conducted a longitudinal, population-based retrospective cohort study in adult @entity0 with @entity2 from 2002 to 2012 using a nationwide health insurance claims database. The study sample included individuals aged 40 years and over who developed @entity2 in 2005 and survived until 2006. We performed a Cox proportional hazard regression analysis with COC analyzed as a time-dependent covariate. RESULTS: Of the 3,090 @entity0 , 60.8% died before the end of study (N = 1,879). The median years of survival for individuals with high COC (COC index>= 0.75) was 3.92, and that for @entity0 with low COC (COC index<0.75) was 2.58 in a Kaplan Meier analysis. In a multivariate, time-dependent analysis, low COC was associated with a 22% increased risk of all-cause mortality (HR, 1.22; 95% CI, 1.09-1.36). Not receiving @entity1 therapy at home was associated with a 23% increased risk of all-cause mortality (HR, 1.23; 95% CI, 1.01-1.49). Moreover, the risk of all-cause mortality for individuals who admitted one time increased 38% (HR, 1.38; 95% CI, 1.21-1.59), two times was 63% (HR, 1.63; 95% CI, 1.34-1.99) and 3+ times was 96% (HR, 1.96; 95% CI, 1.63-2.36) relative to the reference group (no admission). CONCLUSIONS: High COC was associated with a decreased risk of all-cause mortality. In addition, home @entity1 therapy and number of hospital admissions may predict mortality in @entity0 with @entity2 .

title: The Association between Continuity of Care and All-Cause Mortality in XXXX with Newly Diagnosed Obstructive Pulmonary Disease: A Population-Based Retrospective Cohort Study, 2005-2012.

answer: @entity0


abstract: The @entity5 ( @entity5 ) classification which proposes new approaches to the diagnosis, terminology and differential diagnosis of @entity1 of the breast was applied to a series of female @entity0 comprising @entity4 oncogene expression which may serve as an adjunct to the morphology by immunohistochemistry. The study was performed using the data of 94 @entity0 . There was no difficulty encountered in the diagnosis of @entity3 ( @entity3 ). In @entity0 with @entity3 ( @entity3 ), the diagnosis could be made by using the 2-mm rule of the @entity5 classification in @entity0 who exhibited cytologic and structural characteristics of @entity6 ( @entity6 ) alone or in conjunction with classical @entity3 patterns. However, in lesions that mimicked classical @entity3 patterns despite displaying cytological features of in situ @entity2 , the experience and view point of the pathologist played a more prominent role. When the @entity5 classification criteria were applied to grade @entity6 , although the system was found to be practical, it did not provide adequate differentiation in intermediate grade (grade II- @entity5 2) @entity0 and further improvement was considered desirable. Fourty-five cases (47.8%) @entity3 , 19 (20.2%) @entity3 , and 30 (31.9%) were @entity6 . There were statistically significant differences in the levels of @entity4 oncogene expression between @entity3 , @entity3 and @entity6 (p<0.001). In DCISs, grade, cell size, pleomorphic nuclear atypia showed statistically significant associations with @entity4 oncogene expression. These results suggest that @entity4 oncogene expression is a valuable marker in the differential diagnosis and prognostic evaluation of @entity0 with @entity1 .

title: @entity4 oncogene expression in XXXX of the breast.

answer: @entity1


abstract: BACKGROUND: Treatment for @entity0 has increased @entity1 survivorship exponentially over the past few decades. With increased survivorship, more @entity1 are living with the longstanding effects of @entity0 treatment, such as @entity4 . @entity1 , health care providers, and payers depend on practical and efficient clinical measures to accurately diagnose and monitor disease progression or regression. However, current clinical measures do not include objective measures that assess lymphedetamous tissue accurately. This study compared current measures to a novel use of ultrasound (US) imaging to quantify tissue texture. METHODS AND RESULTS: Seventeen @entity1 diagnosed with @entity4 completed self-report questionnaires and then were tested twice by two @entity4 physical therapists who measured @entity2 , @entity3 , and limb volume differences. One therapist measured subjects' limbs using US imaging and derived measures of entropy and average pixel intensity. Volume measures were consistent between therapists (p   <   0.01) but palpation was not (0.01   <   p   <   0.72). Therapists' measures correlated better to subjects' self-report of @entity2 (0.01   <   p   >   0.32) as compared to @entity3 (0.23   <   p   >   0.90). US measures were reliable (Cronbachs's a   =   0.7 and 0.91 for entropy and API, respectively). Entropy measures demonstrated significant differences between subjects' involved versus uninvolved forearms (p   =   0.03). CONCLUSIONS: Therapists were not consistent with each other when rating @entity2 or @entity3 ; however, they were consistent when measuring limb volume differences. US measures (entropy) demonstrated a significant difference between involved and uninvolved. US imaging, as a tool to quantify subcutaneous tissues, holds promise to be a safe, mobile, and effective method to measure @entity4 tissue texture.

title: Ultrasound and Clinical Measures for XXXX .

answer: @entity4


abstract: INTRODUCTION: Federally Qualified Health Centers (FQHCs) provide primary care to low-income and uninsured @entity0 in the United States. FQHCs are required to report annual measurements and provide evidence of improvement for quality measures; effective methods to improve quality in FQHCs are needed. Systems of Support (SOS) is a proactive, mail-based, @entity1 screening program that was developed and tested in an integrated health care system. The objective of this study was to adapt SOS for use in an FQHC system, guided by the Consolidated Framework for Implementation Research (CFIR). METHODS: We conducted qualitative semi-structured interviews in 2014 with organizational leadership, medical staff, and nursing staff to identify facilitators of and barriers to implementation of SOS in an FQHC system. The interview guide was based on the CFIR framework. Interview transcripts were analyzed using Template Analysis. We adapted SOS and planned implementation strategies to address identified barriers. RESULTS: Facilitators of implementation of SOS were previous quality improvement experience and engagement of clinic and administrative leadership. Barriers to implementation were a more diverse @entity0 population, a decentralized administrative structure, and communication challenges throughout the organization. Program adaptations focused on @entity0 instructions and educational materials as well as elimination of follow-up phone calls. Implementation strategies included early and frequent engagement with organizational leadership and a smaller pilot program before organization-wide implementation. CONCLUSIONS: Use of CFIR identified facilitators of and barriers to implementation of the evidence-based @entity1 screening program. Program adaptations and implementation strategies based on this study may generalize to other FQHC systems that are considering implementation of a proactive, mail-based @entity1 screening program.

title: Adaptation of an Evidence-Based XXXX Screening Program Using the Consolidated Framework for Implementation Research.

answer: @entity1


abstract: BACKGROUND: Small selected cohort studies suggest that mutations in the cardiac myosin binding protein-C ( @entity4 ) gene cause late-onset, clinically benign @entity1 ( @entity1 ). The aim of this study was to test this hypothesis in a large series of families with @entity1 associated with @entity4 mutations. METHODS AND RESULTS: The initial study population comprised 57 probands with 42 mutations (26 [61.9%] novel) in @entity4 . Missense mutations (15, 45.6%) were the most frequent, and multiple mutations occurred in 4 (7.0%) probands. Another 110 mutation carriers were identified during familial evaluation; 38 were clinically affected with @entity3 >= 13 mm. Disease penetrance was, therefore, incomplete (56.9% in all mutation carriers, 34.5% in relatives), related to age (38.4% <40 versus 68.6% >= 40 years, P<0.001), and was greater in males than females (65.1% versus 48.1%, P=0.03). In 9 families (25 individuals) with the @entity5 mutation, there was marked heterogeneity in age at diagnosis (5 to 80 years), pattern of @entity2 (11 none, 9 asymmetrical, 3 concentric, 1 apical, 1 eccentric), and prognosis (premature @entity0 in 2 individuals compared with survival to advanced age in 6 individuals). During follow up of 7.9+/-4.5 years, in 82 clinically affected individuals the annual risk of @entity0 and all cause mortality was 0.46% and 0.93% per year, respectively. CONCLUSIONS: Disease expression in families with @entity1 related to @entity4 mutations shows marked heterogeneity with incomplete, age-related, and gender specific penetrance. Importantly, complex genetic status is observed and should be considered when mutation analysis and cascade screening is used in the evaluation of at risk family members.

title: Cardiac myosin binding protein-C mutations in families with XXXX : disease expression in relation to age, gender, and long term outcome.

answer: @entity1


abstract: Perturbations of the trans-sarcolemmal and sarcoplasmic @entity0 transport contribute to the abnormal myocardial activity provoked by @entity2 and reoxygenation. Whether @entity0 pools of the extracellular compartment and sarcoplasmic reticulum (SR) are involved to the same extent in the @entity1 of the anoxic-reoxygenated immature heart has not been investigated. Spontaneously contracting hearts isolated from 4-day-old @entity4 embryos were submitted to repeated @entity2 (1 min) followed by reoxygenation (5 min). Heart rate, atrioventricular propagation velocity, ventricular shortening, velocities of contraction and relaxation, and incidence of @entity3 were studied, recorded continuously. Addition of @entity5 (10 nM), which blocks selectively sarcolemmal L-type @entity0 channels, was expected to protect against excessive entry of extracellular @entity0 , whereas addition of @entity6 (10 nM), which opens the SR @entity0 release channel, was expected to increase cytosolic @entity0 concentration. @entity5 (a) had no dromotropic effect by contrast to adult heart, (b) attenuated ventricular contracture induced by repeated @entity2 , (c) shortened cardioplegia induced by reoxygenation, and (d) had remarkable antiarrhythmic properties during reoxygenation specially. On the other hand, @entity6 potentiated markedly @entity3 both during @entity2 and at reoxygenation. Thus despite its immaturity, the SR seems to be functional early in the developing @entity4 heart and involved in the reversible @entity1 induced by @entity2 -reoxygenation. Moreover, @entity0 entry through L-type channels appears to worsen @entity3 especially during reoxygenation. These findings show that the @entity0 -handling systems involved in irregular activity in immature heart, such as the embryonic @entity4 heart, may differ from those in the adult.

title: Effects of @entity5 and @entity6 on activity of the embryonic @entity4 heart during XXXX and reoxygenation.

answer: @entity2


abstract: PURPOSE: @entity6 ( @entity10 ) may play a role in the progression from @entity8 to @entity4 ( @entity4 ). We tested the effects of a highly selective @entity6 ( @entity10 ) inhibitor, @entity13 , on proliferation, migration, and invasion both in @entity0 @entity4 cell lines (8505c(B-Raf @entity10 ) and @entity12 ( @entity11 / @entity7 and wild-type @entity6 )) and in primary @entity0 normal thyroid (NT) follicular cells engineered with or without @entity6 ( @entity10 ). EXPERIMENTAL DESIGN: Large-scale genotyping analysis by mass spectrometry was performed in order to analyze >900 gene mutations. Cell proliferation and migration/invasion were performed upon @entity13 treatment in 8505c, @entity12 , and NT cells. Orthotopic implantation of either 8505c or @entity12 cells into the thyroid of severe combined @entity5 @entity2 was performed. Gene validations were performed by quantitative polymerase chain reaction and immunohistochemistry. RESULTS: We found that @entity13 reduced in vitro cell proliferation and migration and invasion of 8505c cells, causing early downregulation of genes involved in @entity1 progression. @entity13 -treated NT cells overexpressing @entity6 ( @entity10 ) (heterozygous wild-type @entity6 / @entity6 ( @entity10 )) showed significantly lower cell proliferation, migration, and invasion. @entity13 treatment did not block cell invasion in @entity12 cells with wild-type @entity6 , which showed very low and delayed in vivo @entity1 growth. In vivo, @entity13 treatment of 8505c orthotopic @entity4 inhibited @entity3 and significantly upregulated the thyroid differentiation markers @entity9 and paired box gene 8. CONCLUSIONS: Here, we have shown that @entity13 preferentially inhibits migration and invasion of @entity6 ( @entity10 ) @entity4 cells and @entity3 . Normal thyroid cells were generated to be heterozygous for wild-type @entity6 / @entity6 ( @entity10 ), mimicking the condition found in most @entity0 @entity4 . @entity13 was effective in reducing cell proliferation, migration, and invasion in this heterozygous model. @entity13 therapy should be tested and considered for a phase I study for the treatment of @entity0 with @entity6 ( @entity10 ) @entity4 .

title: Targeting BRAFV600E with @entity13 displays potent antimigratory and anti-invasive activity in preclinical models of @entity0 XXXX .

answer: @entity4