abstract: GINS is a key component of the eukaryotic @entity0 ( @entity0 )-GINS (CMG) complex, which unwinds duplex DNA at the moving replication fork. Archaeal GINS complexes have been shown to stimulate the @entity3 activity of their cognate @entity0 mainly by elevating its ATPase activity. Here, we report that GINS from the thermoacidophilic crenarchaeon @entity2 (SsoGINS) is capable of DNA binding and binds preferentially to single-stranded DNA (ssDNA) over double-stranded DNA (dsDNA). Notably, SsoGINS binds more strongly to dsDNA with a 5' ssDNA tail than to dsDNA with a 3' tail and more strongly to an ssDNA fragment blocked at the 3' end than to one at the 5' end with a @entity1 -streptavidin (SA) complex, suggesting the ability of the protein complex to slide in a 5'-to-3' direction along ssDNA. DNA-bound SsoGINS enhances DNA binding by SsoMCM. Furthermore, SsoGINS increases the @entity3 activity of SsoMCM. However, the ATPase activity of SsoMCM is not affected by SsoGINS. Our results suggest that SsoGINS facilitates processive DNA unwinding by SsoMCM by enhancing the binding of the @entity3 to DNA. We propose that SsoGINS stabilizes the interaction of SsoMCM with the replication fork and moves along with the @entity3 as the fork progresses. IMPORTANCE: GINS is a key component of the eukaryotic Cdc45- @entity0 -GINS complex, a molecular motor that drives the unwinding of DNA in front of the replication fork. Archaea also encode GINS, which interacts with @entity0 , the @entity3 . But how archaeal GINS serves its role remains to be understood. In this study, we show that GINS from the hyperthermophilic archaeon @entity2 is able to bind to DNA and slide along ssDNA in a 5'-to-3' direction. Furthermore, @entity2 GINS enhances DNA binding by @entity0 , which slides along ssDNA in a 3'-to-5' direction. Taken together, these results suggest that @entity2 GINS may stabilize the interaction of @entity0 with the moving replication fork, facilitating processive DNA unwinding.

title: The @entity2 GINS Complex Stimulates DNA Binding and Processive DNA Unwinding by Minichromosome Maintenance XXXX .

answer: @entity3


abstract: @entity4 was studied in 908 @entity0 with @entity3 . A proarrhythmia occurred in 29 (3.2%). When the severity of the proarrhythmia and the type of presenting @entity3 were correlated, no proarrhythmic events occurred in @entity0 who presented with benign @entity3 . Four @entity1 were attributed to the proarrhythmic effects of @entity4 . Of these, 3 occurred in @entity0 presenting with lethal @entity3 . A total of 15 serious proarrhythmic events occurred, all of which resolved without lethal consequence. The overall proarrhythmia incidence in the lethal and potentially lethal @entity3 categories was not different (3.2 vs 3.7%, respectively). Thus, a proarrhythmia occurred in @entity0 with more advanced structural @entity2 , and occurred almost exclusively in @entity0 who presented with potentially lethal or lethal @entity3 . There was no relation between the dose of @entity4 and the incidence of proarrhythmic events. Of the 29 proarrhythmic events, 26 occurred within 7 days (90%) of the initiation of @entity4 therapy. Thus, @entity4 appears to have a low proarrhythmic potential in the populations tested, including @entity0 presenting with lethal @entity3 . The implications of the @entity3 Suppression Trial on such a data base analysis are discussed.

title: Proarrhythmic potential of XXXX : strengths and limitations of a data base analysis.

answer: @entity4


abstract: A 5-week randomized, placebo-controlled, double-blind study was carried out to investigate the efficacy of kava-kava special extract @entity4 in non-psychotic nervous @entity1 , @entity3 and restlessness states. During the first treatment week, the study dose drug was increased from 50 mg to 300 mg per day and pretreatment with @entity2 was tapered off over 2 weeks. These dosage adjustments were followed by 3 weeks of monotherapy with @entity4 or placebo. Outcome measures were the differences between baseline and end of treatment on the Hamilton Anxiety Scale (HAMA) and on a subjective well-being scale (Bf-S), as well as the @entity2 withdrawal symptoms. Changes in the Erlanger Anxiety, Tension and Aggression Scale (EAAS) and Clinical Global Impressions (CGI) were analyzed as secondary measures. Treatment safety was checked by interviews, adverse event reports and laboratory investigations. Forty @entity0 (2x20) were included into the study. @entity4 was superior to placebo regarding the HAMA (P=0.01) and Bf-S (P=0.002) total scores and all secondary efficacy measures. The tolerance of @entity4 was not inferior to placebo. The study confirms the anxiolytic efficacy and good tolerance of @entity4 and shows that a further symptom reduction is possible after a change-over from @entity2 treatment.

title: Efficacy of kava-kava in the treatment of non-psychotic @entity1 , following pretreatment with XXXX .

answer: @entity2


abstract: BACKGROUND: In spite of progress in cardiovascular genetics, data on genetic background of @entity2 are still limited and contradictory. This applies as well to the genes involved in @entity0 and coagulation processes, which play a crucial role in the disease etiopathogenesis. METHODS AND RESULTS: In this study we found genetic variants of @entity4 , @entity3 and CRP genes associated with @entity2 in discovery and replication groups of Russian descent from the Moscow region and the Republic of Bashkortostan (325/185 and 220/197 samples, correspondingly). We also found and replicated biallelic combinations of @entity4 with @entity3 , @entity4 with CRP and @entity1 with @entity5 genetic variants associated with @entity2 providing a detectable cumulative effect. We proposed an original two-component procedure for the analysis of nonlinear (epistatic) interactions between the genes in biallelic combinations and confirmed the epistasis hypothesis for the set of alleles of @entity1 with PTGS. The procedure is applicable to any pair of logical variables, e.g. carriage of two sets of alleles. The composite model that included three single gene variants and the epistatic pair has AUC of 0.66 both in discovery and replication groups. CONCLUSIONS: The genetic impact of @entity4 , @entity3 , CRP, @entity1 , and PTGS and/or their biallelic combinations on @entity2 was found and replicated in Russians. Evidence of epistatic interactions between @entity1 with PTGS genes was obtained both in discovery and replication groups.

title: Variants of the Coagulation and Inflammation Genes Are Replicably Associated with XXXX and Epistatically Interact in Russians.

answer: @entity2


abstract: Study Objectives: In @entity1 , actigraphy tends to underestimate wake time compared to diaries and @entity5 . When @entity4 co-occurs with @entity1 , sleep may be more fragmented, including more movement and arousals. However, individuals may not be consciously aware of these arousals. We examined the baseline concordance of diaries, actigraphy, and @entity5 as well as the ability of each assessment method to detect changes in sleep following cognitive behavioral therapy for @entity1 (CBT-I). Methods: Adults with @entity1 and @entity3 (n = 113) were randomized to CBT-I, CBT for @entity2 , or waitlist control. At baseline and posttreatment, @entity0 completed one night of @entity5 and two weeks of diaries/actigraphy. Results: At baseline, objective measures estimated lower SOL, higher TST, and higher SE than diaries (ps < 0.05). Compared to @entity5 , actigraphic estimates were higher for SOL and lower for WASO (ps < 0.05). Repeated measures ANOVAs were conducted for the CBT-I group (n = 15), and significant method by time interactions indicated that the assessment methods differed in their sensitivity to detect treatment-related changes. @entity5 values did not change significantly for any sleep parameters. However, diaries showed improvements in SOL, WASO, and SE, and actigraphy also detected the WASO and SE improvements (ps < 0.05). Conclusions: Actigraphy was generally more concordant with @entity5 than with diaries, which are the recommended assessment for diagnosing @entity1 . However, actigraphy showed greater sensitivity to treatment-related changes than @entity5 ; @entity5 failed to detect any improvements, but actigraphy demonstrated changes in WASO and SE, which were also found with diaries. In comorbid @entity1 / @entity3 , actigraphy may therefore have utility in measuring treatment outcomes.

title: Measuring Treatment Outcomes in Comorbid XXXX and @entity3 : Concordance of Subjective and Objective Assessments.

answer: @entity1


abstract: Brainstem serotonergic neurotransmission is implicated in sleep regulation. However, the role of @entity3 ( @entity3 ) in forebrain regions in sleep-wake mechanisms is still unclear. Here, we have investigated, using a combined in vivo microdialysis/electroencephalogram method, the relationship between hippocampal @entity3 levels and sleep-wake behaviour in the @entity1 . A clear-cut relationship was found between hippocampal @entity3 levels and vigilance state. The highest levels of @entity3 were observed during wakefulness, whereas a progressive decrease of @entity3 going from nonrapid eye movement @entity6 was found. @entity4 ( @entity4 ) causes a transient enhancement of mood in @entity2 @entity0 . Given the putative role of @entity3 in the aetiology of @entity2 and the therapeutical efficacy of selective @entity3 reuptake inhibitors in this illness, we also studied hippocampal @entity3 during 4 h of @entity4 and during the subsequent recovery period. During the whole @entity4 period, @entity3 levels were elevated substantially when compared to @entity3 levels during basal wakefulness. However, no changes in @entity3 levels and the relationship between hippocampal @entity3 and vigilance state were found during the subsequent recovery period. As @entity4 is a potentially stressful experience and glucocorticoids are involved in the regulation of serotonergic neurotransmission and sleep, we investigated the effects of @entity4 on free @entity5 levels. @entity4 caused a marked rise in free @entity5 levels. However, the effects of @entity4 on @entity3 seem not to be mediated by this hormone, because adrenalectomy did not affect the rise in hippocampal @entity3 during @entity4 . We hypothesize that the elevated hippocampal @entity3 levels during @entity4 may participate in the transient mood enhancing properties of forced wakefulness observed in @entity2 @entity0 .

title: Effect of XXXX on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in @entity1 .

answer: @entity4


abstract: BACKGROUND: @entity1 ( @entity1 ) are a rare occurrence in well-differentiated @entity5 . The aim of this study was to analyze the clinical, pathologic, and molecular features of primary @entity5 with low-risk histology that develop @entity1 . METHODS: A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated @entity5 lacking gross extrathyroidal extension, extensive @entity7 , or significant lymph node @entity1 but exhibiting @entity1 . RESULTS: Primary well-differentiated @entity5 with low-risk histologic features and @entity1 was a rare occurrence, accounting for only 3% of metastatic non-anaplastic @entity5 . All 15 cases meeting the inclusion criteria harbored @entity1 at presentation. The majority (11/15) of these @entity2 were follicular variant of @entity10 ( @entity10 ), especially the encapsulated form (n   =   8). The remaining @entity0 harbored encapsulated H  rthle cell @entity4 (n   =   2), encapsulated @entity4 (n   =   1), and an encapsulated @entity8 classical variant (n   =   1). Of the 12 encapsulated @entity4 , 10 had capsular invasion only and no @entity7 . Ninety-two percent of the @entity2 exhibited extensive intra-tumoral @entity3 . Among the eight @entity2 that were subjected to next-generation sequencing analysis, a RAS mutation was the main driver (5/8), and @entity9 promoter mutation was highly prevalent (6/8). In four cases, @entity9 promoter mutations were associated with RAS or @entity6 mutations. @entity6 -mutated classical variant of @entity8 also presented with @entity1 but was less common (1/8). In 11/15 cases, the clinician was able to diagnose distant disease based on the clinical presentation. In 3/4 incidental cases that were genotyped, @entity9 promoter mutations were found. CONCLUSIONS: When @entity1 occur in primary @entity5 with low-risk histology, they are almost always found at presentation. The majority are encapsulated follicular variant of @entity10 with capsular invasion only. @entity9 promoter mutations occur at a higher rate than that seen in @entity10 in general and may help explain the aggressive behavior of these histologically deceptive primary @entity4 .

title: Primary XXXX with Low-Risk Histology and Distant Metastases: Clinicopathologic and Molecular Characteristics.

answer: @entity5


abstract: PURPOSE: To report the clinical outcomes from 2 academic centers of the @entity2 ( @entity2 ) @entity3 for coverage of posterior elbow soft tissue defects. METHODS: We retrospectively reviewed 17 @entity0 who underwent an @entity2 @entity3 for posterior elbow wound reconstruction over an 8-year period at 2 academic centers. Outcome measures included visual analog score for @entity1 ; Disabilities of the Arm, Shoulder, and Hand score; Mayo Elbow Performance score; range of motion; wound healing; grip strength; and isokinetic dynamometry for wrist flexion. Wilcoxon signed-rank test was used to make side-to-side comparisons between the operative and nonsurgical extremities, and nonparametric statistical methods were used to analyze results. RESULTS: All wounds healed successfully without need for revision surgery. Average visual analog, Disabilities of the Arm, Shoulder, and Hand, and Mayo Elbow Performance scores in the operative elbow were 1.8, 34, and 86, respectively. Average elbow arc of motion was 11   to 140   with 70   forearm pronation and 73   forearm supination. Compared with the nonsurgical side, grip strength on the operated side was 97% and wrist flexion peak torque was 89%. The operative limb had an average wrist flexion fatigue of 7%, compared with 22% for the nonsurgical arm. CONCLUSIONS: @entity0 receiving an @entity2 @entity3 had reliable healing, minimal @entity1 , good functional outcomes, and no meaningful deficits in grip strength or wrist flexion strength. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

title: Clinical Outcomes of the Flexor Carpi Ulnaris  Turnover XXXX for Posterior Elbow Soft  Tissue Defects.

answer: @entity3


abstract: UNASSIGNED: @entity1 is @entity6 that develops @entity3 and is less frequent in @entity0 and @entity0 than in adults. Likewise, in animal models of @entity1 , @entity7 and @entity7 are non-existent or attenuated in the @entity0 , with a "switch" during development by which @entity5 transitions to @entity6 . Concomitant with the delay in @entity1 , there is a parallel delay in the ability of @entity3 to activate the immune system. Models of @entity1 in the @entity0 have used various ligation methods and find that @entity1 does not occur under after postnatal days 21-28 (PN21-PN28), linked to activation of immune processes and developmental regulation of anti-inflammatory cytokines. We applied a model of @entity1 in the adult using a transient compression of the cervical nerve or nerve root in @entity0 @entity2 (injured at 10, 14, 21, or 28   days of age) to define transition periods during which injury results in no change in thermal and mechanical @entity4 sensitivity or in short-term changes in @entity4 . There was little to no @entity7 when the injury was imposed at PN10, but significant thermal @entity7 and mechanical @entity7 1   day after @entity8 when performed at PN14, 21, or 28. Thermal withdrawal latencies returned to near baseline by 7   days postsurgery when the injuries were at PN14, and lasted up to 14   days when the injury was imposed at PN28. There was mechanical @entity7 following injury at 1   day postinjury and at 14   days after injury at PN14. Measurements of mRNA from spinal cord at 1, 7, and 14   days postinjury at PN14, 21, and 28 showed that both the magnitude and duration of elevated immune markers and chemokines/cytokines were greater in the older animals, corresponding to the development of @entity7 . Thus, we confirm the late onset of @entity1 but found no evidence of @entity7 if the injury was before PN21. This may be due to the use of a transient, and not sustained, compression ligation model.

title: Developmental Changes in @entity4 and Spinal Immune Gene Expression after Radicular Trauma in the XXXX .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Purposes of this study are to describe different parenchymal changes seen after radiosurgery of @entity4 and the clinical symptoms which can be associated, and risk factors correlated with them. @entity0 : and method. From the whole population of 705 @entity0 with a @entity4 treated by radiosurgery between 1984 and 1998, clinical from 615 @entity0 and post radiosurgery MRI data from 367 @entity0 were reviewed. @entity1 occurred in 5.37% of cases and was still persistant in 1.46% of cases. Delay of occurrence of deficits ranged from 6 to 83 months (mean: 27 months, median: 15 months). Parenchymal changes seen in MRI were classified in 4 grades: 1 without parenchymal changes, 2 hypersignal in sp T2, 3=2 with homogenous enhancement with @entity3 , 4 with hyposignal in @entity5 and annular irregular enhancement. Several parameters (size, volume, angioarchitecture of the @entity4 , dosimetric parameters) were studied and correlations were searched by uni and multivariate analysis with occurrence and delay of occurrence of deficits or parenchymal changes. RESULTS: In multivariate analysis, only size was significantly correlated with occurrence of parenchymal changes (p=0.0016); only size of the @entity2 was significantly correlated with delay of occurrence of parenchymal changes (p=0.0082); only grade 4 was correlated with occurrence of @entity1 (p<0.00001). However, when only "a priori" parameters (known before radiosurgery) are introducted in logistic model, size taille (p=0.02) and hypoplasy of a sinus (p=0.0049) are significantly correlated with occurrence of @entity1 . Only parenchymal changes grade 4 was significantly correlated with delay of occurrence of a @entity1 (p<0.00001). However, when only a priori parameters (known before radiosurgery) are introducted in logistic model, only arterial steal (p=0.054) was significantly correlated with delay of occurrence of a @entity1 . CONCLUSION: Parenchymal changes are various in expression, signification and clinical symptoms associated with them. They must be known and recognized for better prevention and symptomatic treatment as well.

title: [Parenchymal changes after radiosurgery of XXXX . Clinical and MRI data].

answer: @entity4


abstract: PURPOSE: The aim of this study was to investigate contemporary patterns of presentation and outcome in newborns with @entity4 with or without @entity5 ( @entity3 ) using modern prognostic criteria to appraise survival. METHODS: Over a 12-year period (1986 through 1997), 134 @entity0 with @entity3 were admitted to a single institution. @entity0 demographics, the presence of @entity2 , other associated abnormalities (VACTERL), surgical intervention, and @entity0 outcome were recorded. To identify and evaluate changes in the pattern of clinical presentation, frequency of associated anomalies and outcome, @entity0 were analyzed during 4 consecutive time periods, 1986 to 1988, 1989 to 1991, 1992 to 1994, and 1995 to 1997. RESULTS: A primary repair or delayed primary repair was performed in 113 (84%) @entity0 , with a staged procedure in 19 (14%). Two babies with trisomy 18 did not undergo surgery. Thirty-eight newborns (28%) had a major @entity2 (excluding patent ductus arteriosus, unless needing ligation), and 25 (19%) had recognized VACTERL associations. There was a significant increase in the proportion of @entity0 with major @entity2 diagnosed over the study period, 5 of 34 @entity0 between 1986 and 1988 to 19 of 41 @entity0 between 1995 and 1997 (chi(2) test, P <.001), but the incidence of VACTERL associations remained unchanged. Overall survival rate was 86% in those who underwent surgery. The relative risk of mortality in @entity0 with major @entity2 and VACTERL associations was 3.47 (95% CI; 1.51 to 7.96) and 2.54 (95% CI; 1.14 to 4.86), respectively. Birth weight was significantly higher in @entity0 who survived (2.68 kg) compared with those who died (2.16 kg, P =.003). Thirty percent of @entity0 with more than one system abnormality died compared with 8% of @entity0 with 1, system abnormality (P =.004). CONCLUSIONS: This study has found a significant increase in the frequency of @entity2 encountered in a cohort of @entity3 @entity0 during the period under review. @entity2 and @entity1 carried a substantial increased risk of mortality. In the era of the Spitz classification, the phenotypic presentation is important to accurately assess caseload severity and prognosis.

title: Phenotypic presentation and outcome of XXXX in the era of the Spitz classification.

answer: @entity4


abstract: Retinal development occurs in @entity0 between embryonic day E11.5 and post-natal day P8 as uncommitted neuroblasts assume retinal cell fates. The genetic pathways regulating retinal development are being identified but little is understood about the global networks that link these pathways together or the complexity of the expressed gene set required to form the retina. At E14.5, the retina contains mostly uncommitted neuroblasts and newly differentiated neurons. Here we report a sequence analysis of an E14.5 retinal cDNA library. To date, we have archived 15 268 ESTs and have annotated 9035, which represent 5288 genes. The fraction of singly occurring ESTs as a function of total EST accrual suggests that the total number of expressed genes in the library could approach 27 000. The 9035 ESTs were categorized by their known or putative functions. Representation of the genes involved in eye development was significantly higher in the retinal clone set compared with the NIA @entity0 15K cDNA clone set. Screening with a microarray containing 864 cDNA clones using wild-type and @entity1 (-/-) retinal cDNA probes revealed a potential regulatory linkage between the transcription factor @entity1 and expression of @entity2 , a protein associated with axon growth. The retinal EST database will be a valuable platform for gene expression profiling and a new source for gene discovery.

title: Gene expression in the developing XXXX retina by EST sequencing and microarray analysis.

answer: @entity0


abstract: A combined measles-mumps- @entity3 (MMRV) vaccine is expected to facilitate universal immunization against these 4 diseases. This study was undertaken to synthesize current research findings of the immunogenicity and safety of MMRV in healthy @entity0 .We searched PubMed, Embase, BIOSIS Previews, Web of Science, Cochrane Library, and other databases through September 9, 2014. Eligible randomized controlled trials (RCTs) were selected and collected independently by 2 reviewers. Meta-analysis was conducted using Stata 12.0 and RevMan 5.3.Twenty-four RCTs were included in qualitative synthesis. Nineteen RCTs compared single MMRV dose with measles-mumps- @entity3 vaccine with or without varicella vaccine (MMR+V/MMR). Similar seroconversion rates of these 4 viruses were found between comparison groups. There were comparable geometric mean titers (GMTs) against @entity4 viruses between MMRV group and MMR+V/MMR group. MMRV group achieved enhanced immune response to measles component, with GMT ratio of 1.66 (95% confidence interval [CI] 1.48, 1.86; P<0.001) for MMRV versus MMR and 1.62 (95% CI 1.51, 1.70; P<0.001) for MMRV versus MMR+V. Meanwhile, immune response to @entity3 component in MMRV group was slightly reduced, GMT ratios were 0.81 (95% CI 0.78, 0.85; P<0.001) and 0.79 (95% CI 0.76, 0.83; P<0.001), respectively. Well tolerated safety profiles were demonstrated except higher incidence of @entity1 (relative risks 1.12-1.60) and measles/ @entity3 -like @entity2 (relative risks 1.44-1.45) in MMRV groups.MMRV had comparable immunogenicity and overall safety profiles to MMR+V/MMR in healthy @entity0 based on current evidence.

title: Combination Measles-Mumps-Rubella-Varicella Vaccine in Healthy XXXX : A Systematic Review and Meta-analysis of Immunogenicity and Safety.

answer: @entity0


abstract: The prognostic factors associated with local failure and overall survival and the effect of radiotherapy were determined in 77 @entity0 with localized (extremity and nonextremity) operable soft-tissue @entity3 . There were 52 male and 25 female @entity0 ; median age was 50 years (range: 15-83). Histologic grade of the @entity2 was as follows: low-intermediate grade in 32 cases and high grade in 29 cases. The @entity2 were treated by marginal resection (20 @entity0 ), wide resection (52 @entity0 ), and radical resection (5 @entity0 ). Adjuvant radiotherapy was applied to 50 (65%) @entity0 . The 5-year local recurrence-free survival rate was 70.6%. Treatment with adjuvant radiotherapy and development of @entity1 were the significant prognostic factors associated with local recurrence. Radiotherapy was more effective in @entity0 with @entity2 10 cm or larger, marginally resected, extremity located, and high grades. The overall survival rate was 64.4% at 5 years. Significant adverse prognostic factors were high grade @entity2 , presence of local recurrence, and development of @entity1 in univariate analyses. Development of @entity1 and old age were the only adverse prognostic factors by multivariate analysis. The best 5-year survival rate was obtained in female @entity0 younger than 50 years (90%). The present study demonstrated the importance of adjuvant radiotherapy and development of @entity1 as prognostic factors for local control. Again, development of @entity1 and age were the most important prognostic factors in operable soft-tissue @entity3 .

title: Prognostic factors in localized soft-tissue XXXX .

answer: @entity3


abstract: @entity4 , @entity3 and @entity0 are @entity1 derivates. They differ in their substitution on the @entity2 ring and may have different effects on membranes. Red blood cells were used as a prototypical cellular system regarding drug mediated plasma bilayer effects. Established photometric methods sensing tiny changes of red blood cell morphology at rest (red blood cell shape) and at very low shear forces (red blood cell stiffness, red blood cell relaxation time) were applied. The derivative induced effects were detected in a time- and dose-dependent manner. @entity4 induced a most pronounced echinocytic shape at 5 mM. The shape effect was smaller above as well as below 5 mM. @entity3 induced echinocytes with increasing concentrations showing a saturation above 10 mM. In contrast, the shape was not affected by @entity0 . All shape changes occurred within 2 min, and were reversible. The above tendencies were in parallel to a slight red blood cell stiffening. The relaxation time continuously increased with increasing concentrations in both @entity4 and @entity3 , with @entity4 always acting stronger. @entity0 again showed no effect. We hypothesize that the observed effects of @entity3 and @entity4 are due to their phenolic character mediating a molecular hydrophobicity. According to the bilayer couple hypothesis this would lead to an insertion into the red blood cells outer plasma bilayer leaflet. The extension induced here would cause a positive membrane bending leading to echinocytic shapes and the observed loss of red blood cell fluidity. In contrast, the hydrophilic @entity0 would penetrate and thus not affect the red blood cell plasma membrane.

title: Effects of XXXX derivatives on red blood cell membranes.

answer: @entity1


abstract: BACKGROUND: Excessive skin is a side-effect of massive @entity3 . The only evidence-based treatment for @entity2 is plastic surgery. Non-invasive treatments, therefore, need to be evaluated. The aim of this study was to investigate effects of therapeutic ultrasound treatment on excess skin on the upper arms after bariatric surgery. METHOD: Fourteen @entity0 were randomised to receive five treatments, each lasting for 30 minutes with active ultrasound treatment by CellsonicTM (Cellsonic Ltd) on one arm. The other arm served as control. The effect was evaluated objectively by measuring arm volume, circumference, and @entity4 , and subjectively by a questionnaire where the @entity0 assessed the effect of the treatment and amount and/or discomfort of the excess skin. RESULT: No statistical differences were observed in the objectively measured variables. Some @entity0 reported perceived effects and a majority reported positive experiences of the treatment. No side-effects were reported. CONCLUSION: This study could not find any objectively measured effect of ultrasound treatment on @entity2 after bariatric surgery. However, @entity0 experienced relief of symptoms associated with excess skin, such as @entity1 , looseness, and decreased skin burst, which indicates that ultrasonic treatment of @entity0 with @entity2 should be further investigated.

title: Therapeutic ultrasound treatment for @entity2 on the upper arms due to extensive XXXX after bariatric surgery: A single blind, randomised, controlled trial.

answer: @entity3


abstract: IMPORTANCE: Problem adaptation therapy (PATH) is a treatment for older adults with @entity3 , @entity1 (from mild @entity1 to moderate @entity2 ), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated. OBJECTIVE: To test the efficacy of 12-week PATH vs supportive therapy for @entity1 @entity0 (ST-CI) in reducing @entity3 and disability in 74 older adults with @entity3 , @entity1 , and disability. DESIGN, SETTING, AND @entity0 : A randomized clinical trial at the Weill Cornell Institute of Geriatric Psychiatry from April 1, 2006, to September 31, 2011. Interventions were administered at the @entity0 ' homes. @entity0 included 74 older individuals (age >=  65 years) with @entity3 and @entity1 to the level of moderate @entity2 . They were recruited through collaborating community agencies of Weill Cornell Institute of Geriatric Psychiatry and were randomly assigned to 12 weekly sessions of PATH or ST-CI (14.8% attrition rate). INTERVENTIONS: Home-delivered PATH vs home-delivered ST-CI. Problem adaptation therapy integrates a problem-solving approach with compensatory strategies, environmental adaptations, and caregiver participation to improve @entity0 ' emotion regulation. Supportive therapy for @entity1 @entity0 focuses on expression of affect, understanding, and empathy. MAIN OUTCOMES AND MEASURES: Mixed-effects models for longitudinal data compared the efficacy of PATH with that of ST-CI in reducing @entity3 (Montgomery-Asberg Depression Rating Scale) and disability (World Health Organization Disability Assessment Schedule II) during 12 weeks of treatment. RESULTS: @entity0 in PATH had significantly greater reduction in @entity3 (Cohen d, 0.60; 95% CI, 0.13-1.06; treatment * time, F(1,179) = 8.03; P =   .005) and disability (Cohen d, 0.67; 95% CI, 0.20-1.14; treatment * time, F(1,169) = 14.86; P =   .001) than ST-CI @entity0 during the 12-week period (primary outcomes). Furthermore, PATH @entity0 had significantly greater @entity3 remission rates than ST-CI @entity0 (37.84% vs 13.51%;   (2) = 5.74; P =   .02; number needed to treat = 4.11) (secondary outcome). CONCLUSIONS AND RELEVANCE: Problem adaptation therapy was more efficacious than ST-CI in reducing @entity3 and disability. Problem adaptation therapy may provide relief to a large group of @entity1 older adults who have few treatment options. TRIALS REGISTRATION: Clinicaltrials.gov Identifier: NCT00368940.

title: Problem adaptation therapy for older adults with XXXX and @entity1 : a randomized clinical trial.

answer: @entity3


abstract: UNASSIGNED: Tectonic  -1 ( @entity3 ) is an upstream gene involved in embryonic development. The aim of the present study was to investigate the effect of the @entity3 gene on the viability and @entity2 cells. Lentivirus  -mediated short hairpin RNA (shRNA) was constructed to silence the expression of @entity3 in PC  -3 and DU145 @entity2 cells. Cell viability and proliferation were measured using @entity1 and colony formation assays, and the distribution of cells in phases of the cell cycle was determined using flow cytometry. Cell migration was detected using a Transwell assay. The results demonstrated that @entity3 was widely expressed in several @entity0 @entity2 cell lines. Knockdown of the @entity3 gene by RNA interference markedly suppressed cell viability and colony formation in the PC  -3 and DU145 cell lines. Cell cycle progression was also arrested by @entity3 silencing. In addition, knockdown of the @entity3 gene led to the inhibition of cell migration in the two cell lines. These findings confirmed the direct association between the @entity3 gene and @entity2 growth in  vitro. With further understanding and clinical investigation, this indicates the potential for future development of a novel marker for early detection and gene therapy for @entity2 .

title: Tectonic  -1 contributes to the growth and XXXX cells in  vitro.

answer: @entity2


abstract: @entity2 is the bacterial pathogen which is responsible for approximately 80% of all cases of @entity0 @entity3 . It can invade and remain within osteoblasts. The fate of intracellular Staph. aureus after the death of the osteoblast has not been documented. We exposed @entity0 osteoblasts to Staph. aureus. After @entity1 , the osteoblasts were either lysed with Triton X-100 or trypsinised. The bacteria released from both the trypsinised and lysed osteoblasts were cultured and counted. Colonies of the recovered bacteria were then introduced to additional cultures of @entity0 osteoblasts. The number of intracellular Staph. aureus recovered from the two techniques was equivalent. Staph. aureus recovered from time zero and 24 hours after @entity1 , followed by lysis/trypsinisation, were capable of invading a second culture of @entity0 osteoblasts. Our findings indicate that dead or dying osteoblasts are capable of releasing viable Staph. aureus and that Staph. aureus released from dying or dead osteoblasts is capable of reinfecting @entity0 osteoblasts in culture.

title: Intracellular @entity2 . A mechanism for the indolence of XXXX .

answer: @entity3


abstract: PURPOSE: Multi-detector row CT (MDCT) is a new noninvasive modality for coronary artery imaging. Using the same MDCT data obtained for coronary artery assessment, left ventricular (LV) volumes such as end-diastolic (ED) and end-systolic (ES) volumes (EDV and @entity2 , respectively) and ejection fraction (EF) can potentially be assessed when ED and ES datasets are extracted. The purpose of this study was to evaluate the feasibility of MDCT in the assessment of LV volumes. METHODS: Using a pulsating heart phantom (EDV = 143 ml, @entity2 = 107 ml, @entity1 volume = 36 ml, EF = 25%) and MDCT, EDV and @entity2 were measured and EF was calculated. Clinical materials consisted of 11 consecutive @entity0 subjects who underwent MDCT. MDCT data were acquired during a single breathhold, using an intravenous injection of contrast medium. Left ventriculography (LVG) was performed in all @entity0 as a gold standard. LV-EF was calculated by measuring @entity2 and EDV in all @entity0 . RESULTS: In the phantom study, LV volumes were: EDV = 137 ml, @entity2 = 101 ml, @entity1 volume = 36 ml, and EF = 26%. Close correlations were observed between MDCT values and LVG values (EDV: r = 0.95, @entity2 : r = 0.98, EF: r = 0.93, p < 0.001). CONCLUSION: MDCT was useful for th e assessment of LV volumes and EF in various @entity0 with CVD.

title: Assessment of left ventricular volumes using multi-detector row computed tomography (MDCT): phantom and XXXX studies.

answer: @entity0


abstract: UNASSIGNED: DNA damage response (DDR) consists of both proapoptotic and prosurvival signaling branches. Superiority of each signaling branch determines the outcome of DNA damage: death or allowing the repair. The present authors have previously shown that an increased intracellular level of cAMP disrupts @entity2 -mediated apoptosis in @entity0 pre-B @entity0 cells and inhibition of NF-kB prevents prosurvival effect of cAMP during DNA damage. @entity1 /PKB (protein kinase B) is a general mediator of survival signaling. @entity1 signaling inhibits @entity2 -mediated transcription and apoptosis. The results of present study showed that cAMP disrupted DNA damage/ @entity2 -mediated apoptosis through @entity1 and subsequent NF-kB activation. These results suggested that @entity1 may be found as part of a complex with scaffolding proteins, beta-arrestins and @entity3 . cAMP disarticulated the complex through binding to @entity3 compartment. It seems that release of @entity1 protein potentiated DDR activated pro-survival @entity1 in @entity0 cells. Taken together, the present data indicated that regulation of @entity1 signaling may determine the fate of cells exposed to genotoxic stress.

title: PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in XXXX pre-B @entity0 cells.

answer: @entity0


abstract: BACKGROUND _ AIMS: Serologic profiles after @entity2 surface antigen (HBsAg) seroclearance in @entity3 ( @entity3 ) have not been well-studied. METHODS: We employed a highly sensitive HBsAg (hs-HBsAg) assay (lower detection limit 0.5 mIU/ml), 100 times more sensitive than conventional HBsAg measurements. @entity3 @entity0 achieving HBsAg seroclearance defined by conventional assays were followed up for serum hs-HBsAg, @entity1 DNA and antibody to HBsAg (anti-HBs) levels at 0 months, 6-12 months and 3-5 years after HBsAg seroclearance. Factors associated with hs-HBsAg detectability were determined. RESULTS: One hundred and nine @entity0 were recruited; 94 (86.2%) were followed up to years 3-5; and 25 @entity0 (22.9%) were on nucleoside analogue therapy for a median duration of 6.0 (range 1.5-12.7) years before HBsAg seroclearance. Detectable hs-HBsAg was noted in 88 (80.7%), 60 (55.0%) and 20 (21.3%) @entity0 at 0 months, 6-12 months and 3-5 years respectively. At years 3-5, genotype B @entity0 , when compared to genotype C @entity0 , had a higher anti-HBs positive rate (63.2% and 41.1% respectively, P = 0.036). Serum anti-HBs positivity, when compared to persistent anti-HBs negativity, was associated with a lower rate of hs-HBsAg detection (7.4% and 40% respectively, P < 0.001). Multivariate analysis showed anti-HBs negativity at years 3-5 to be independently associated with persistently positive hs-HBsAg (P = 0.007, odds ratio 7.1, 95% confidence interval 1.7-29.3). CONCLUSION: Serum hs-HBsAg could detect HBsAg presence in a substantial proportion of @entity3 after HBsAg seroclearance defined by conventional assays, especially among anti-HBs negative individuals. Serum hs-HBsAg could potentially assist differentiating HBsAg-negative @entity3 from individuals with only past @entity1 exposure without carrier state.

title: Longitudinal profiles of highly sensitive XXXX surface antigen levels: re-evaluation of HBsAg seroclearance.

answer: @entity2


abstract: OBJECTIVE: There has been no clear evidence supporting similar chemo-responses for upper and lower @entity5 . METHODS: We conducted a multicenter retrospective cohort study to analyze @entity5 @entity0 who underwent systemic chemotherapy at 17 centers from 2004 to 2010. A total of 298 @entity0 with either @entity4 (N = 151) or upper tract @entity5 (N = 147) were included. Differences in @entity2 location ( @entity4 vs. upper tract @entity5 ) were evaluated in relation to the @entity0 backgrounds and clinical responses to systemic chemotherapy. RESULTS: Overall 216 @entity0 were treated with @entity7 -based chemo-regimens ( @entity3 and @entity7 in 92, or @entity9 , @entity10 , @entity6 and @entity7 / @entity9 , @entity8 and @entity7 in 124). Among 186 initially metastatic @entity0 , the incidences of lung @entity1 and liver @entity1 were 39.2 and 34.1%, respectively, in upper tract @entity5 @entity0 , and were significantly higher than those with @entity4 (22.4% for lung; 8.4% for liver @entity1 ). Among 112 post-surgical recurrent/metastatic @entity0 , age was significantly higher and estimated glomerular filtration rate at baseline was significantly lower in upper tract @entity5 @entity0 than those with @entity4 . No significant differences were observed in overall clinical response rates for systemic chemotherapy between @entity4 (45.8%) and upper tract @entity5 (38%) in initially metastatic @entity0 or between @entity4 (43.2%) and upper tract @entity5 (44.1%) in post-surgical recurrent/metastatic @entity0 . @entity2 location was not independently associated with @entity2 -specific survival in either initially metastatic or post-surgical recurrent/metastatic @entity5 @entity0 . CONCLUSIONS: No significant difference was observed in response rates of @entity4 and upper tract @entity5 to systemic chemotherapy, suggesting that a similar chemo-regimen can be applied to metastatic @entity5 @entity0 regardless of @entity2 location (upper vs. lower).

title: Do metastatic upper tract @entity5 and XXXX have similar clinical responses to systemic chemotherapy? A Japanese multi-institutional experience.

answer: @entity4


abstract: OBJECTIVE AND IMPORTANCE: We report two cases of massive @entity3 resulting from @entity2 . Both @entity0 had experienced a @entity7 and were initially moribund. The @entity0 were treated with Guglielmi detachable coiling and then administration of intraventricular @entity6 (tPA). Rapid clot resolution was demonstrated radiographically in both. Both @entity0 survived and had a meaningful functional neurological recovery. These are the first reported cases of the acute use of intraventricular tPA after Guglielmi detachable coiling treatment for @entity7 . CLINICAL PRESENTATION: A 59-year-old @entity0 and a 44-year-old @entity0 presented with high-grade @entity2 . Both had had extensive casting of their ventricular systems with blood. INTERVENTION: The @entity0 were treated with Guglielmi detachable coiling @entity4 of the @entity1 and then intraventricular administration of tPA for dissolution of @entity8 . Both @entity0 survived; one is able to carry out activities of daily living with moderate assistance, and the other is able to communicate with his family. CONCLUSION: This is a novel method to manage @entity0 with high-grade @entity1 with @entity8 . The tPA reduced the mass effect of the @entity8 , possibly helping to improve the neurological grade; in addition, the administration of tPA helped keep the external ventricular drains functional, enabling treatment of the acute @entity5 . The safety of administering tPA after endovascular @entity4 was demonstrated in these two @entity0 . Further investigation is required to determine the applicability of this approach on a broader scale.

title: Use of intraventricular XXXX and Guglielmi detachable coiling for the acute treatment of casted ventricles from cerebral aneurysm hemorrhage: two technical case reports.

answer: @entity6


abstract: We investigated the intrathecally administrated unbilical cord mesenchymal stem cells (UC-MSCs) by lumbar puncture and assessed the technical difficulties and effects in various neurological conditions. One hundred @entity0 underwent subarachnoid placement of UC-MSCs between December 2006 and May 2010 in the Affiliated Hospital of Medicine. @entity10 in @entity0 in the form of localization of subarachnoid space, number of attempts, and post-procedural complications were evaluated. Functional evaluation was done using Hauser Ambulation Index (HAI) by the stem cell transplant team on a regular basis. All @entity0 were followed-up for more than 1 yr after the treatment. Clinical symptoms, related biochemical index and photographic examinations were observed regularly. We encountered technical difficulties in 31 @entity0 (31%) in the form of general anesthesia supplementation and difficulty localizing the lumbar space. Side effects ( @entity1 , low-grade fever, @entity8 and @entity4 ) were observed in 22 (22%) @entity0 , which were treated with symptomatic therapy within 48 h. One year after the treatment, functional indices improved in 47 @entity0 (47%): 12 @entity0 with @entity7 , 11 @entity0 with @entity6 , 9 @entity0 with @entity3 , 9 @entity0 with post- @entity11 , 3 @entity0 with @entity5 , and 3 @entity0 with @entity9 . In conclusion, intrathecal administration of UC-MSCs is a safe and effective way to treat @entity2 . Our encouraging results of intrathecal administration of UC-MSCs indicate the potential of restoration of lost tissue and improvement of function in @entity0 with profound @entity2 and inefficient conventional cure. These data support expanded double-blind, placebo-controlled studies for this treatment modality.

title: Umbilical cord mesenchymal stem cells in XXXX : A clinical study.

answer: @entity2


abstract: OBJECTIVES: To compare anti-inflammatory effect of @entity4 and @entity5 in @entity0 of @entity2 . MATERIALS AND METHODS: The study was a prospective, open-labeled, randomized and single-center study conducted on 100 @entity0 of @entity2 . @entity0 were assigned to @entity4 40 mg daily or @entity5 20 mg daily for 4 weeks. @entity3 ( @entity3 ) levels, lipid profiles, erythrocyte sedimentation rate (ESR) and adverse effects were measured at beginning and at the end of 4 weeks. RESULTS: Baseline parameters and clinical profile did not differ between the two groups. @entity3 levels significantly decreased from beginning to the end of 4 weeks in both @entity4 and @entity5 groups (from 35.48 to 23.07 mg/l and from 35.88 to 19.91 mg/l respectively, both P < 0.001). However, there was significant difference between the levels of @entity3 in @entity0 of the @entity5 group as compared to the @entity4 group (19.91    6.32 vs 23.07    7.47, P < 0.05). In addition, both the drugs were associated with a reduction in total @entity1 , LDL levels and ESR at the end of 4 weeks as compared to the beginning (P < 0.001 for all comparisons). CONCLUSION: Both @entity4 (40 mg) and @entity5 (20 mg) are effective in decreasing @entity3 and LDL @entity1 levels even in a short duration of 4 weeks. @entity5 was found to be more effective in decreasing @entity3 levels.

title: Comparison of anti-inflammatory effect of @entity4 with @entity5 in XXXX of @entity2 .

answer: @entity0


abstract: HISTORY: A 22 year old @entity0 had noted progressive @entity5 without recognizable urinary abnormalities for five days. INVESTIGATIONS: A urologist had noted increased serum @entity6 (2.1 mg/dl), @entity2 (180/100 mmHg) and microhematuria. A post-renal cause was excluded by excretory urography. An interview revealed that the @entity0 had consumed @entity8 on weekends since age 19; the acute episode was preceded by a rave party with consumption of a total of 3 g of street quality @entity8 . DIAGNOSIS AND TREATMENT: Because of microhematuria with a suggestive nephritic urinary sediment, the @entity0 underwent renal biopsy. It showed @entity9 and @entity1 , but no signs of @entity3 and negative immunohistology. The patient received antihypertensive treatment. This led to rapid reversal of elevated serum @entity7 and microhematuria was noted, but @entity2 persisted. Currently the @entity0 receives ACE inhibitors. CONCLUSION: Similar to what is seen in the US, @entity8 use has to be considered in the differential diagnosis of @entity4 with @entity2 .

title: [Acute renal failure and XXXX crisis after a technoparty].

answer: @entity2


abstract: UNASSIGNED: @entity2 are one of the characteristic adverse events associated with @entity5 chemotherapy. In this retrospective study, we investigated the frequency and outcome of @entity2 associated with @entity5 chemotherapy in @entity1 @entity0 . This retrospective study included 75 advanced @entity1 @entity0 who received @entity5 monotherapy between January 2014 and December 2015. We retrospectively evaluated the frequency, Grade, and @entity2 . @entity2 were observed in 16 @entity0 (21%). The median time of onset was 3(range, 1-8)months. Grade 2 @entity2 , eye discharge, and @entity3 were reported in 14, 8, and 4 @entity0 , respectively. Artificial tears, @entity4 eye-drops, and both of these treatments were used in 7, 1, and 8 @entity0 , respectively. Ophthalmologic examination was performed for 3 @entity0 . No delay or reduction of @entity5 therapy was required for the @entity2 . @entity2 associated with @entity5 therapy in @entity1 @entity0 did not affect treatment if managed properly using eye drops.

title: [Eye Disorders Associated with @entity5 Chemotherapy in @entity1 XXXX ].

answer: @entity0


abstract: UNASSIGNED: In a prospective community-based cohort study, we investigated the relationship between @entity1 ( @entity1 ) and regional fat depots in 1474 Korean postmenopausal @entity0 . @entity1 was positively related with subcutaneous fat and negatively related with visceral fat. INTRODUCTION: The effect of fat distribution (visceral/subcutaneous) on bone quality or microarchitecture has rarely been investigated due to measurement difficulty. We aimed to investigate the relationship between @entity1 reflecting bone microarchitecture and regional fat depots in Korean @entity0 . METHODS: Cross-sectional data evaluation was made from subjects participating in an ongoing prospective community-based cohort study since 2001. A total of 1474 postmenopausal @entity0 in the Ansung cohort were analyzed. Regional body fat mass, bone mineral density (BMD) at the lumbar spine, and total hip and lumbar spine @entity1 were measured by dual energy X-ray absorptiometry (DXA). RESULTS: In an age-adjusted partial correlation analysis, @entity1 was not associated with total fat mass, but negatively associated with trunk fat mass. However, @entity1 was positively related with leg (r   =   0.102, P   <   0.05) and gynoid fat mass (r   =   0.086, P   <   0.05) and negatively related with android fat mass (r   =   -0.106; P   <   0.05). In linear regression models controlling age, BMI, and physical activity, android fat was inversely associated with @entity1 (b   =   -0.595, P   <   0.001), whereas gynoid fat was positively associated with @entity1 (b   =   0.216, P   <   0.001). Lumbar spine and total hip BMDs revealed positive associations with total and all regional fat depots regardless of fat distribution. CONCLUSION: Our findings suggest that relatively large visceral fat and small subcutaneous fat may have a detrimental effect on @entity1 , a bone microarchitecture index.

title: Regional body fat depots differently affect bone microarchitecture in postmenopausal Korean XXXX .

answer: @entity0


abstract: The results of a longterm prospective follow-up study after the 'Double @entity4 Scheie filtering operation are presented. Fifty-two eyes of 47 @entity0 with @entity3 ( @entity3 ) were operated; after ten years 29 eyes of 24 @entity0 could be examined. Twenty @entity0 (43%) had died, in three follow-up was incomplete. The two and four year results have been published earlier. In the 29 eyes the mean intraocular pressure (IOP) without medical therapy rose from 15.8 mm Hg at five years to 16.3 mm Hg at ten years (not significant). Additional medical or surgical treatment was necessary in 35% of the eyes. Diurnal variation and outflow facility remained stable. During the ten years 13 eyes showed some @entity1 . Nearly all clinically important deterioration occurred within five years after the operation. @entity2 progression was noticed in 45% (13 of 29); four times a lens extraction was performed (13%). Complete success of the operation, as judged by stable visual fields and IOP levels at or under 21 mm Hg without additional medical or surgical therapy was reached in 13 of 20 eyes (45%). Based on IOP alone the success rate was 62% without and 93% with additional treatment.

title: Ten year prospective follow-up of a glaucoma operation. The Double @entity4 Scheie in XXXX .

answer: @entity3


abstract: BACKGROUND: Although @entity1 ( @entity1 ) are a global health problem affecting every region of the world, the higher prevalence and mortality rate of @entity1 in developing countries of the world, like Nigeria, make them serious public health issues in this region. OBJECTIVE: The aim of this study is to assess the knowledge and perception of young adults in Nigeria on the role of condom (both male and female condoms) as a preventive measure against @entity1 during heterosexual and homosexual intercourse. MATERIALS AND METHODS: Data was collected from @entity0 selected from the northern and southern Nigeria using self-administered questionnaire specifically designed for this study. RESULTS: Knowledge of condom efficacy in STI prevention was satisfactory. However, knowledge and practice of the correct use of condom was poor. Only 47.1% of the 102 @entity0 in this study reported correct condom use of wearing condoms before staring intercourse and removing condoms after ejaculation. As a strategy to include the experiences, knowledge and perception of @entity0 who have sex with @entity0 , this study asked the question on condom use during anal sex. Only 24.4% of the male @entity0 indicated they have never had anal sex while for females, the percentage was more than half (53.5%). Condom use during anal sex was low with only 20.6% of @entity0 reporting condom use during anal sex. Negative perceptions about condom use - such as that condom use promotes sexual promiscuity, and not using condoms with steady sexual partners - were significant in this study. Also, condom use errors were common in this study. CONCLUSION: There is a wide gap in knowledge of correct condom use in this population. There is need for interventions that address the issue of condom use during anal and same-sex sexual intercourse in this population.

title: Knowledge and perception of young adults in Nigeria on effectiveness of condom use in prevention of XXXX .

answer: @entity1


abstract: 1. @entity1 - @entity6 -dependent protein kinase II (CaMK) and a @entity6 ( @entity6 )-binding 'IQ' domain (IQ) are both implicated in @entity1 -dependent regulation of L-type @entity1 current (I( @entity5 )). We used an IQ-mimetic peptide (IQmp), under conditions in which CaMK activity was controlled, to test the relationship between these @entity6 -activated signalling elements in the regulation of L-type @entity1 channels (LTCCs) and I( @entity5 ) in @entity0 ventricular myocytes. 2. A specific CaMK inhibitory peptide nearly abolished I( @entity5 ) facilitation, but the facilitation was 'rescued' by cell dialysis with IQmp. 3. IQmp significantly enhanced I( @entity5 ) facilitation and slowed the fast component of I( @entity5 ) inactivation, compared with an inactive control peptide. Neither effect could be elicited by a more avid @entity6 -binding peptide, suggesting that generalized @entity6 buffering did not account for the effects of IQmp. 4. I( @entity5 ) facilitation was abolished and the fast component of inactivation eliminated by @entity4 , @entity3 or @entity2 , suggesting that the sarcoplasmic reticulum (SR) is an important source of @entity1 for I( @entity5 ) facilitation and inactivation. IQmp did not restore I( @entity5 ) facilitation under these conditions. 5. Engineered @entity1 -independent CaMK and IQmp each markedly increased LTCC open probability (P(o)) in excised cell membrane patches. The LTCC P(o) increases with CaMK and IQmp were non-additive, suggesting that CaMK and IQmp are components of a shared signalling pathway. 6. Both CaMK and IQmp induced a modal gating shift in LTCCs that favoured prolonged openings, indicating that CaMK and IQmp affect LTCCs through a common biophysical mechanism. 7. These findings support the hypothesis that CaMK is required for physiological I( @entity5 ) facilitation in cardiac myocytes. Both CaMK and IQmp were able to induce a modal gating shift in LTCCs, suggesting that each of these signalling elements is important for @entity1 - @entity6 -dependent LTCC facilitation in cardiac myocytes.

title: @entity6 kinase and a @entity6 -binding 'IQ' domain facilitate L-type XXXX current in @entity0 ventricular myocytes by a common mechanism.

answer: @entity1


abstract: BACKGROUND/PURPOSE: The intussusception-type antireflux valve is a mechanism introduced by Nakajo, who reported the results of his initial 17 cases in 1990. This report summarizes our further experience with new @entity0 , together with follow-up results of the cases previously reported by Nakajo. METHODS: In total, 46 new @entity0 who had @entity4 underwent portoenterostomy at the authors' two units. The authors hoped to construct the intussuscepted antireflux valve in the Roux-en-Y loop, whenever possible, at the time of hepatic portoenterostomy. RESULTS: Among the 46 @entity0 , one case each was found to be too young or too old to have the valve constructed during the surgery. In another case, the Roux-en-Y loop became too short after repeated revisions of the portoenterostomy. In another @entity0 , the valve was first constructed but later removed because of jejunal perforation near the valve. In the last @entity0 , the valve was not constructed for unspecified reasons. The authors constructed the antireflux valve in 42 @entity0 , but it was maintained in 41. In one case, the valve truly prevented reflux of the intestinal juice during an episode of @entity3 . The valve was found to be incompetent in one @entity0 5 years after the initial surgery. CONCLUSION: The incidence of @entity1 was high in @entity0 with @entity2 of the intrahepatic bile ducts, and low in those without it.

title: Further experience with the antireflux valve to prevent XXXX in @entity4 .

answer: @entity1


abstract: OBJECTIVES: To estimate the proportion of @entity0 with @entity3 2 @entity1 who were eligible for @entity4 treatment per American @entity1 Association (ADA) recommendations and the proportion who were actually prescribed a @entity4 in US clinical practice. Factors associated with receiving a @entity4 prescription were also determined. METHODS: @entity0 >=  25 years diagnosed with @entity3 2 @entity1 or had received prescriptions for antihyperglycemic agents between 7/2006 and 6/2008 were identified within a large electronic medical record database. Eligibility for @entity4 therapy was determined according to 2008 ADA recommendations. @entity4 use was assessed based on prescription records during a 12-month follow-up period. An adjusted logistic regression analysis was performed to estimate the likelihood of @entity4 use in relation to selected baseline characteristics. RESULTS: Of the 125,464 @entity0 identified, 98.5% were eligible for @entity4 therapy. Only 62.9% received a @entity4 prescription during follow-up period. In an adjusted logistic regression, factors associated with increased likelihood of @entity4 use were older age, male gender, smoking, history of @entity2 , and receiving an antihyperglycemic, antihypertensive, or anticoagulant prescription at baseline (all p < 0.05). LIMITATIONS: Of the @entity0 who did not receive @entity4 during follow-up, 13% of them were previously on a @entity4 during the baseline period. The reasons for discontinuing therapy are not known. It cannot be excluded that some of these @entity0 were intolerant or had contraindications to @entity4 . The data on prescription dispensing and compliance were not recorded. CONCLUSIONS: Nearly all @entity0 with @entity3 2 @entity1 were eligible for @entity4 therapy, but less than two-thirds received @entity4 therapy in US clinical practice. Efforts to minimize this gap are warranted.

title: Underutilization of statins in @entity0 with @entity3 2 XXXX in US clinical practice: a retrospective cohort study.

answer: @entity1


abstract: BACKGROUND: Cognitive behavioural therapy for @entity0 with @entity2 is a psychotherapeutic approach that establishes links between thoughts, emotions and behaviours and challenges dysfunctional thoughts. There is some evidence to suggest that cognitive behavioural therapy for @entity0 with @entity3 (CBTp) might be an effective treatment for @entity0 with @entity2 . There are however, limitations in its provision due to available resource and training issues. One way to tackle this issue might be to offer a brief version of CBTp. OBJECTIVES: To review the effects of brief CBTp (6 to 10 regular sessions given in less than 4 months and using a manual) for @entity0 with @entity2 compared with standard CBTp (12 to 20 regular sessions given in 4 to 6 months and using a manual). SEARCH METHODS: We searched the Cochrane @entity2 Group's Trials Register (August 21, 2013 and August 26, 2015) which is based on regular searches of CINAHL, BIOSIS, AMED, EMBASE, PubMed, MEDLINE, PsycINFO and registries of Clinical Trials. There are no language, date, document type, or publication status limitations for inclusion of records in the register. We inspected all references of the selected articles for further relevant trials. We also contacted experts in the field regarding brief CBTp studies. SELECTION CRITERIA: Randomised controlled trials involving adults with @entity2 or @entity1 , comparing brief cognitive behavioural therapy for @entity0 with @entity3 versus standard CBTp. DATA COLLECTION AND ANALYSIS: Two review authors independently screened and assessed studies for inclusion using pre-specified inclusion criteria. MAIN RESULTS: We found only seven studies which used a brief version of CBTp, but no study compared brief CBTp with CBTp of standard duration. No studies could be included. AUTHORS' CONCLUSIONS: Currently there is no literature available to compare brief with standard CBTp for @entity0 with @entity2 . We cannot, therefore, conclude whether brief CBTp is as effective, less effective or even more effective than standard courses of the same therapy. This lack of evidence for brief CBTp has serious implications for research and practice. Well planned, conducted and reported randomised trials are indicated.

title: Cognitive behavioural therapy (brief versus standard duration) for XXXX .

answer: @entity2


abstract: Rhizobium tropici forms @entity3 -fixing nodules on the roots of the common bean ( @entity6 ). Like other legume-Rhizobium symbioses, the bean-R. tropici association is sensitive to the availability of @entity2 (P(i)). To better understand @entity4 movement between the bacteroid and the host plant, P(i) transport was characterized in R. tropici. We observed two P(i) transport systems, a high-affinity system and a low-affinity system. To facilitate the study of these transport systems, a Tn5B22 transposon mutant lacking expression of the high-affinity transport system was isolated and used to characterize the low-affinity transport system in the absence of the high-affinity system. The K(m) and V(max) values for the low-affinity system were estimated to be 34 +/- 3 microM P(i) and 118 +/- 8 nmol of P(i) x min(-1) x mg (dry weight) of cells(-1), respectively, and the K(m) and V(max) values for the high-affinity system were 0.45 +/- 0.01 microM P(i) and 86 +/- 5 nmol of P(i) x min(-1) x mg (dry weight) of cells(-1), respectively. Both systems were inducible by P(i) starvation and were also shock sensitive, which indicated that there was a periplasmic binding-protein component. Neither transport system appeared to be sensitive to the proton motive force dissipator @entity5 , but P(i) transport through both systems was eliminated by the ATPase inhibitor @entity7 ; the P(i) transport rate was correlated with the intracellular @entity0 concentration. Also, P(i) movement through both systems appeared to be unidirectional, as no efflux or exchange was observed with either the wild-type strain or the mutant. These properties suggest that both P(i) transport systems are ABC type systems. Analysis of the transposon insertion site revealed that the interrupted gene exhibited a high level of homology with kdpE, which in several bacteria encodes a cytoplasmic response regulator that governs responses to low @entity1 contents and/or changes in medium osmolarity.

title: Characterization of two inducible XXXX transport systems in Rhizobium tropici.

answer: @entity2


abstract: BACKGROUND: The @entity2 ( @entity2 ) Foundation recommends @entity0 attend clinic >= 4 times per year with 4 respiratory cultures and 2 pulmonary function tests (PFTs). However, nationally only 57.4% of @entity0 met these guidelines in 2012. We used a quality improvement program with a goal of 75% of our @entity0 meeting this care guideline by 2012. METHODS: A 2-stage program was started in 2011. Stage 1: education of @entity0 /caregivers on importance of quarterly visits. Stage 2: quarterly tracking system of @entity0 appointments. Data on clinic visits, respiratory cultures, and PFTs were collected from the @entity2 registry from January 2009 through December 2013. Statistical process control charts were used to track improvements. RESULTS: The average number of clinic visits increased significantly from 4.6    2.3 in 2009 to 6.3    4.6 in 2013 (P < .0001). The percentage of @entity0 ages 6 through 18 completing a clinic visit, PFT, and respiratory culture per quarter increased significantly from 76.2% during 2009 to 86.4% in 2013. The percentage of @entity0 completing >= 4 clinic visits with 4 respiratory cultures and 2 PFTs improved significantly from 47.5% in 2009 to 71.0% in 2013 (P < .0001). CONCLUSIONS: A tracking system of @entity0 appointments significantly improved adherence to the care guidelines better than education alone. The multiple-stage quality improvement program we implemented may be modifiable and able to be integrated in other @entity2 centers or other multiple disciplinary @entity1 care centers.

title: Improvements in XXXX Quarterly Visits, Lung Function Tests, and Respiratory Cultures.

answer: @entity2


abstract: OBJECTIVE: To study the prevalence of Barrett esophagus (BE) ( @entity4 ) in adolescents treated for @entity5 ( @entity5 ). SUMMARY OF BACKGROUND DATA: @entity5 @entity0 are at high risk of BE. METHODS: This multicenter prospective study included @entity5 @entity0 aged 15 to 19 years. All eligible @entity0 were proposed an @entity6 with multistaged esophageal biopsies under general anesthesia. Histological suspicion of @entity8 was confirmed centrally. RESULTS: One hundred twenty @entity0 [mean age, 16.5 years (  1.4)] were included; 70% had been treated for @entity3 ( @entity3 ) during infancy. At evaluation, 8% were undernourished, 41% had received antireflux surgery, and 41% presented with @entity3 symptoms, although only 28% were receiving medical treatment. @entity7 was found at endoscopy in 34% and confirmed at histology in 67%. BE was suspected after endoscopy in 37% and was confirmed by histology for 43% of @entity0 (50 gastric and 1 intestinal @entity8 ). No endoscopic or histological anomalies were found at the @entity1 site. BE was not significantly related to clinical symptoms. In multivariate analysis, BE was associated with @entity5 without @entity2 (P = 0.03), previous multiple antireflux surgery (P = 0.04), esophageal dilation (P = 0.04), suspicion of BE at endoscopy (P < 0.001), and histological @entity7 (P = 0.02). CONCLUSIONS: @entity0 with @entity5 are at high risk of persistent @entity3 and BE. The development of BE is related to @entity3 history. Long-term systematic follow-up of the esophageal mucosa including multistaged biopsies is required, even in asymptomatic @entity0 . (NCT02495051).

title: Prevalence of Barrett Esophagus in Adolescents and Young Adults With XXXX .

answer: @entity5


abstract: This study was undertaken to (1) determine the incidence of articular @entity5 in @entity0 with instability of the glenohumeral joint, (2) determine whether recurrent dislocations increased the risk of @entity1 , and (3) correlate these injuries with postoperative clinical outcomes. A cohort was identified of consecutive @entity0 who underwent diagnostic magnetic resonance imaging and shoulder arthroscopy for glenohumeral instability with documented dislocation or subluxation between 1997 and 2006 at a single institution. @entity0 with moderate or severe @entity4 were excluded. Arthroscopic findings were recorded, including lesion location and Outerbridge grade. The American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES) was used to assess outcome in 61 @entity0 who were available for follow-up. Outcomes were compared between shoulders with and without @entity2 . A total of 87 shoulders (83 @entity0 ) met the inclusion criteria, with 69 (83%) @entity0 and 14 (17%) @entity0 . Mean age was 26.1 years (range, 18-64 years), and mean follow-up was 36 months (range, 33-39 months). @entity5 were found in 56 shoulders (64%). Previously documented shoulder dislocation requiring closed reduction (P=.046) and the number of discrete dislocations (P=.032) were significant for @entity3 . A greater number of dislocations was associated with higher-grade lesions of the glenohumeral joint (P<.001). Overall, mean ASES score was 89.6 (range, 37-100). In @entity0 with an articular cartilage lesion, mean ASES score was 90.4 (range, 58-100) compared with 88.1 (range, 37-100) in those without this injury (P=.75). Although clinical outcomes were not significantly affected, further investigation is warranted to establish a relationship between these injuries and longer-term outcomes. [Orthopedics. 2015; 38(11):e965-e969.].

title: The Effect of XXXX After Arthroscopic Stabilization for Shoulder Instability.

answer: @entity5


abstract: The increased knowledge regarding @entity3 in @entity2 ( @entity2 ) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on @entity1 site and geographical origin of the @entity0 , ii) proportion of @entity1 among HPV-DNA-positive cases, and iii) identification of @entity0 with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 @entity2 cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and @entity4 -status and combined results with the @entity0 outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non- @entity5 were HPV-mRNA-positive. Although the study cohort was composed of @entity0 from regions of rather close proximity, prevalence rates showed diversities of up to 40% in @entity2 subsite analysis with the lowest prevalence for @entity5 in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified @entity4 alone as strongest predictor, followed by HPV-DNA-status alone or in combination with @entity4 . This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on @entity3 in @entity2 to, e.g. clarify to what extent survival benefits of @entity4 -positive @entity0 are truly attributed to @entity3 .

title: Geographical and anatomical influences on human papillomavirus prevalence diversity in XXXX in Germany.

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to determine the best tolerated and efficacious dose of @entity8 given once or twice in 3-week cycles in combination with @entity11 and @entity10 (VMF). @entity1 AND METHODS: @entity8 40 mg/m(2) was given as follows: 20 mg/m(2) on days 1 and 8 (group 1); 30 mg/m(2) on day 1 and 10 mg/m(2) on day 8 (group 2); or 40 mg/m(2) on day 1 (not exeeding 60 mg/m(2)) (group 3). The @entity11 dose was 40 mg/m(2) on day 1 and the @entity10 dose 600 mg/m(2) on days 1 and 8. Thirty @entity1 with evaluable @entity2 were randomly allocated to the groups (first step). The second step was to exclude the worst tolerated regimen and then to expand the study to 60 @entity1 . Thus, group 1 had 26 @entity1 , group 2 had 24 @entity1 and group 3 had 10 @entity1 . RESULTS: World Health Organization (WHO) grade 3 hematological @entity3 occurred in 23%, 36% and 50% of @entity1 and grade 4 in 39%, 32% and 50% of @entity1 in groups 1, 2 and 3, respectively; grade 3 @entity4 were observed in 15%, 9% and 10% of @entity1 in groups 1, 2 and 3, and grade 4 @entity4 in 5% and 10% of @entity1 in groups 2 and 3, respectively. Nonhematological @entity3 included a mild to moderate @entity12 manifesting as @entity7 , abdominal colics and @entity6 in the majority of @entity1 . One @entity1 in group 3 had serious @entity5 after @entity8 administration; she also developed @entity9 ; all symptoms were reversible. No @entity1 died from side-effects. The objective response rates were 50%, 55% and 44% for groups 1, 2 and 3, respectively. Median time to progression was 7, 10 and 8 months and median survival time was 26, 23 and 16 months in groups 1, 2 and 3, respectively. CONCLUSION: VMF regimens where the @entity8 dose (40 mg/m(2)) is divided (20 + 20 mg/m(2) and 30 + 10 mg/m(2)) between days 1 and 8 of a 3-week cycle are equally well tolerated and the efficacy is comparable to other modern first line regimens used in the treatment of metastatic @entity0 .

title: @entity8 , XXXX and @entity10 (VMF) as first-line therapy in metastatic @entity0 : a randomized phase II trial.

answer: @entity11


abstract: BACKGROUND: A prospective 1-year study was conducted to assess the frequency, clinical spectrum, histologic description, and follow-up of @entity2 unrelated to ingestion of caustic or corrosive agents. METHODS: The diagnosis of @entity2 was based on a diffusely black esophagus at endoscopy and typical histologic features of @entity1 . Ingestion of caustic and corrosive agents was excluded in all @entity0 . Medical history, associated diseases, and clinical symptoms were recorded for each @entity0 . Nutritional status was evaluated based on clinical and biochemical parameters. Treatment included short-term parenteral nutrition and intravenous administration of a pump proton inhibitor. A second endoscopy was performed when possible at 2 weeks after presentation to assess regression of @entity2 . RESULTS: Among 3900 @entity0 who underwent EGD, 8 (0.2%) with @entity2 were identified. Nutritional status was poor for 6 @entity0 . Complete resolution of @entity2 without further recurrence was observed in 4. No esophageal strictures appeared during follow-up. Four @entity0 died, but no death was directly related to @entity2 . CONCLUSION: Acute @entity1 is not as infrequent an endoscopic finding as has been reported. Acute @entity1 appears to be associated with poor general health status and is not a purely local phenomenon.

title: Acute XXXX : a 1-year prospective study.

answer: @entity1


abstract: OBJECTIVE: To investigate predictors of @entity4 in @entity3 . DESIGN: Cross-sectional study. Height, weight and waist circumference were measured using standard procedures. Overweight and @entity1 in adolescents aged 10-17 years were assessed using the International Obesity Taskforce cut-offs, while the WHO adult cut-offs were used for @entity0 aged 18-20 years. Waist-to-height ratio of >0.5 @entity2 in those at Tanner stages 3-5. Linear and logistic regression analysis was used to evaluate risk factors. SETTING: Agincourt sub-district, @entity3 . SUBJECTS: @entity0 (n 1848) were aged 10-20 years. RESULTS: Combined overweight and @entity1 was higher in @entity0 (15 %) than @entity0 (4 %), as was @entity2 (15 % and 2 %, respectively). With regard to overweight/ @entity1 , fourfold higher odds were observed for @entity0 and twofold higher odds were observed for @entity0 from households with the highest socio-economic status (SES). The odds for overweight/ @entity1 were 40 % lower if the household head had not completed secondary level education. For @entity2 , the odds increased 10 % for each unit increase in age; @entity0 had sevenfold higher odds v. @entity0 ; post-pubertal @entity0 had threefold higher odds v. pubertal @entity0 ; those with older mothers aged 50+ years had twofold higher odds v. those whose mothers were aged 35-49 years; those in highest SES households had twofold higher odds v. those in lowest SES households. CONCLUSIONS: In @entity3 , adolescent females are most at risk of @entity1 which increases with age and appears to be associated with higher SES. To intervene effectively, it is essential to understand how household factors influence food choice, diet and exercise.

title: Predictors of adolescent weight status and XXXX in @entity3 .

answer: @entity2


abstract: UNASSIGNED: Migrant Chinese populations in Western countries have a high prevalence of @entity2 but often experience poor access to healthcare and late diagnosis. This systematic review aimed to identify obstacles and supports to timely and appropriate health service use among these populations. Systematic searches resulted in 48 relevant studies published between 1996 and 2015. Data extraction and synthesis were informed by models of healthcare access that highlight the interplay of @entity0 , provider and health system factors. There was strong consistent evidence of low levels of knowledge among @entity0 and community members; but interventions that were primarily focused on increasing knowledge had only modest positive effects on testing and/or vaccination. There was strong consistent evidence that Chinese migrants tend to misunderstand the need for healthcare for @entity1 and have low satisfaction with services. Stigma was consistently associated with @entity1 and there was weak but consistent evidence of stigma acting as a barrier to care. However, available evidence on the effects of providing culturally appropriate services for @entity1 on increasing uptake is limited. There was strong consistent evidence that health professionals miss opportunities for testing and vaccination. Practitioner education interventions may be important but evidence of effectiveness is limited. A simple prompt in @entity0 records for primary care physicians improved the uptake of testing; and a dedicated service increased targeted vaccination coverage for new-borns. Further development and more rigorous evaluation of more holistic approaches that address @entity0 , provider and system obstacles are needed. This article is protected by copyright. All rights reserved.

title: Improving access to health care for XXXX among migrant Chinese populations: a systematic mixed methods review of barriers and enablers.

answer: @entity2


abstract: UNASSIGNED: We performed a simulation study to evaluate the performances of an @entity0 detection algorithm considered in the frame of an automated surveillance system of @entity2 mortality. The method consisted in a combination of temporal regression and spatial cluster detection which allows identifying, for a given week, clusters of spatial units showing an excess of @entity1 in comparison with their own historical fluctuations. First, we simulated 1,000 outbreaks of a disease causing extra @entity1 in the French @entity2 population (about 200,000 herds and 20 million @entity2 ) according to a model mimicking the spreading patterns of an infectious disease and injected these disease-related extra @entity1 in an authentic mortality dataset, spanning from January 2005 to January 2010. Second, we applied our algorithm on each of the 1,000 semi-synthetic datasets to identify clusters of spatial units showing an excess of @entity1 considering their own historical fluctuations. Third, we verified if the clusters identified by the algorithm did contain simulated extra @entity1 in order to evaluate the ability of the algorithm to identify unusual mortality clusters caused by an outbreak. Among the 1,000 simulations, the median duration of simulated outbreaks was 8 weeks, with a median number of 5,627 simulated @entity1 and 441 infected herds. Within the 12-week trial period, 73% of the simulated outbreaks were detected, with a median timeliness of 1 week, and a mean of 1.4 weeks. The proportion of outbreak weeks flagged by an alarm was 61% (i.e. sensitivity) whereas one in three alarms was a true alarm (i.e. positive predictive value). The performances of the detection algorithm were evaluated for alternative combination of epidemiologic parameters. The results of our study confirmed that in certain conditions automated algorithms could help identifying abnormal @entity2 mortality increases possibly related to unidentified health events.

title: Simulation-Based Evaluation of the Performances of an Algorithm for Detecting Abnormal Disease-Related Features in XXXX Mortality Records.

answer: @entity2


abstract: OBJECTIVE: This study aimed to describe the clinical and histopathologic findings in four @entity0 with complex limbal @entity16 associated with @entity15 ( @entity15 ), a @entity3 including nevus sebaceous, @entity4 , and @entity7 , and often accompanied by @entity5 . DESIGN: Small observational case series. METHODS: A retrospective review of the clinical and histopathologic records of four @entity0 . RESULTS: Each of four @entity0 had complex limbal @entity16 in the setting of clinical and histopathologic @entity15 . The limbal @entity16 were multiple in three @entity0 and bilateral in two @entity0 . Most @entity16 involved the superotemporal limbus (6 of 10), although nasal (3 of 10) and @entity1 also were present. Three @entity0 had significant corneal @entity6 or involvement of the central cornea requiring surgical removal of their @entity16 , one accompanied by a lamellar keratoplasty and another accompanied by two consecutive penetrating keratoplasties. Each graft eventually vascularized, reducing vision. One @entity0 's vision was limited by amblyopia and another by occipital cortical @entity17 with @entity2 . Histopathologic examination of the excised @entity16 showed foci of lacrimal gland (3 of 4 @entity0 ), adipose tissue (3 of 4), neural tissue (1 of 4), cartilage (1 of 4), lymphoid follicles (1 of 4), skin adnexal tissue (1 of 4), and smooth muscle (1 of 4). Other associated ocular findings included an eyelid mass (1 of 4), @entity12 of the eyelid (3 of 4), @entity12 of the choroid and retina (2 of 4), nonparalytic strabismus (2 of 4), @entity13 (1 of 4), partial @entity9 with @entity8 and anisocoria (1 of 4), @entity11 (1 of 4), @entity14 (1 of 4), and cortical @entity2 (1 of 4). CONCLUSIONS: Complex limbal @entity16 , although rare, can occur in the setting of @entity15 and can be associated with multiple ocular and @entity10 . Visual prognosis appears poor in most cases despite aggressive management.

title: Complex limbal XXXX .

answer: @entity15


abstract: Defence against invading DNA occurs in both mammals and bacteria. Recognition of stray DNA can initiate responses to infection, but may also protect against potentially mutagenic integration of transposons or retrotransposons into the genome. Double-stranded DNA detected in the cytosol of @entity0 macrophages can elicit inflammatory cytokines and cell death following assembly of the @entity3 inflammasome. Amongst eukaryotes, responses to cytosolic DNA have so far only been detected in mammals, and @entity3 is @entity0 restricted. In protecting genome integrity, we reasoned that pathways recognising invading DNA should be fundamental to cellular life, and that cell death would be an appropriate response to an overwhelming foreign DNA burden. We found that @entity2 S2 cells were killed by transfection of DNA from a range of natural sources. Unlike with @entity0 cells, responses were not prevented by DNA denaturation. There was an element of sequence specificity, as synthetic single-stranded homopolymers were not toxic, whilst mixed-base synthetic DNA caused significant cell death. @entity1 occurred with rapid loss of membrane integrity, and without the characteristic features of apoptosis. We have defined a novel defence against invading DNA in @entity2 . An active necrotic pathway has not previously been described in insects.    2014 S. Karger AG, Basel.

title: A Novel Pathway of Cell XXXX in Response to Cytosolic DNA in @entity2 Cells.

answer: @entity1


abstract: PURPOSE: Nomograms are statistically based tools that provide the overall probability of a specific outcome. They have shown better individual discrimination than the current @entity3 staging system in numerous @entity0 @entity1 models. The pancreatic nomogram combines individual clinicopathologic and operative data to predict disease-specific survival at 1, 2, and 3 years from initial resection. A single US institution database was used to test the validity of the @entity2 nomogram established at Memorial Sloan-Kettering Cancer Center. @entity0 AND METHODS: The nomogram was created from a prospective @entity2 database that included 555 consecutive @entity0 between October 1983 and April 2000. The nomogram was validated by an external @entity0 cohort from a retrospective @entity2 database at Massachusetts General Hospital that included 424 consecutive @entity0 between January 1985 and December 2003. RESULTS: Of the 424 @entity0 , 375 had all variables documented. At last follow-up, 99 @entity0 were alive, with a median follow-up time of 27 months (range, 2 to 151 months). The 1-, 2-, and 3-year disease-specific survival rates were 68% (95% CI, 63% to 72%), 39% (95% CI, 34% to 44%), and 27% (95% CI, 23% to 32%), respectively. The nomogram concordance index was 0.62 compared with 0.59 with the American Joint Committee on Cancer (AJCC) stage (P = .004). This suggests that the nomogram discriminates disease-specific survival better than the AJCC staging system. CONCLUSION: The @entity2 nomogram provides more accurate survival predictions than the AJCC staging system when applied to an external @entity0 cohort. The nomogram may aid in more accurately counseling @entity0 and in better stratifying @entity0 for clinical trials and molecular @entity1 analysis.

title: Validation of a postresection XXXX nomogram for disease-specific survival.

answer: @entity2


abstract: OBJECTIVE: To evaluate the correlation between @entity2 and @entity1 . STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Eye Department of Postgraduate Medical Institute, Lahore General Hospital, from August 2012 to February 2013. METHODOLOGY: A total of 258 @entity0 suffering from type-2 @entity1 were included. Axial length was measured by two optometrists using contact type ultrasound biometer. Colored retinal photographs, red free retinal photographs and Fundus Fluorescein Angiography (FFA) were performed on all @entity0 using standard fundus camera. All fundus photographs and angiograms were independently reviewed and graded by two qualified vitreoretinal fellows. RESULTS: Out of 258 @entity0 , 163 were males (63.2%) and 95 (36.8%) were females. Average age of @entity0 was 56.30    7.57 years. Average axial length of right and left eyes were 23.16 mm and 23.15 mm respectively. There was statistically significant negative correlation between axial length and severity of @entity1 in the right eye, (Spearman correlation = -0.511, p = 0.0001) as well as the left eye (Spearman correlation = -0.522, p = 0.0001). CONCLUSION: There is a protective influence of longer axial length of globe on the stage and severity of @entity1 . This study may help in modifying the screening protocol for @entity1 amongst @entity0 of differing axial lengths.

title: XXXX and its influence on @entity1 .

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to assess the effectiveness of free tissue transfer for treatment of @entity4 ( @entity5 ) in @entity2 @entity0 . METHODS: We reviewed 29 @entity0 who were treated for advanced mandibular @entity5 by radical resection and reconstruction with free flaps at our institution. All @entity0 had either failed to respond to conservative treatment, including hyperbaric @entity1 therapy and debridement or had @entity3 due to @entity5 . RESULTS: Twenty-four vascularized bone (17 fibula, five iliac, and two scapula), four rectus abdominis myocutaneous, and one radial forearm fasciocutaneous free flaps were used. The complications occurred in 6 of 29 @entity0 (21%). A total of four flaps (14%) were lost. The mean follow-up was 2 years 9 months. All @entity0 had complete resolution of @entity5 symptoms. No evidence of @entity5 recurrence was observed in any @entity0 . CONCLUSION: For advanced @entity5 of the mandible, radical resection followed by reconstruction using free flap provides a reliable means of obtaining good wound healing with acceptable aesthetic and functional results.

title: Management of XXXX with free flap reconstruction.

answer: @entity4


abstract: BACKGROUND: Addition of high-dose @entity6 (HDCA) to the conventional @entity3 /total-body irradiation (CY/ @entity2 ) regimen significantly improved prognosis after cord blood transplantation (CBT) for adult @entity7 ( @entity7 ) and @entity5 ( @entity5 ). The efficacy of HDCA in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT), however, has not yet been elucidated. FINDINGS: We conducted a cohort study to compare the prognosis of HDCA/CY/ @entity2 (N   =   435) and CY/ @entity2 (N   =   1667) in BMT/PBSCT for @entity7 / @entity5 using a Japanese transplant registry database. The median age was 38  years, and 86.0  % of the @entity0 had @entity7 . Unrelated donors comprised 54.6  %, and 63.9  % of donors were human leukocyte antigen (HLA)-matched. Overall survival (OS) was not improved in the HDCA/CY/ @entity2 group (adjusted hazard ratio (HR), 1.14; p   =   0.13). Neutrophil engraftment was inferior (HR, 0.80; p   <   0.01), and the incidence of @entity4 and @entity8 increased in HDCA/CY/ @entity2 (HR, 1.47 and 1.60; p   =   0.06 and 0.04, respectively), leading to significantly higher non-relapse mortality (NRM; HR, 1.48; p   <   0.01). Post-transplant relapse and @entity1 -related mortality were not suppressed by the addition of HDCA. CONCLUSIONS: This study indicated the inefficacy of HDCA/CY/ @entity2 in BMT/PBSCT for @entity7 / @entity5 . Our results should be validated in large-scale prospective studies.

title: Clinical significance of high-dose @entity6 added to XXXX /total-body irradiation in bone marrow or peripheral blood stem cell transplantation for @entity1 .

answer: @entity3


abstract: UNASSIGNED: Benefits of n-3 @entity7 ( @entity11 ) against @entity2 have been reported. Vascular tone regulation is largely mediated by endothelial factors whose release is modulated by sex hormones. Since the incidence of @entity2 has been correlated with decreased levels of sex hormones, the aim of this study was to analyze whether a diet supplemented with the specific @entity11 @entity9 ( @entity10 ) could prevent vascular changes induced by an @entity3 . For this purpose, control and orchidectomized @entity1 were fed with a standard diet supplemented with 5% (w/w) sunflower oil or with 3% (w/w) sunflower oil plus 2% (w/w) @entity10 . The lipid profile, the blood pressure, the production of @entity8 and @entity5 (NO), and the redox status of biological samples from control and orchidectomized @entity1 , fed control or @entity10 -supplemented diet, were analyzed. The vasodilator response and the contribution of NO, @entity8 and hyperpolarizing mechanisms were also studied. The results showed that orchidectomy negatively affected the lipid profile, increased the production of @entity8 and reactive @entity0 species (ROS), and decreased NO production and the antioxidant capacity, as well as the participation of hyperpolarizing mechanisms in the vasodilator responses. The @entity10 -supplemented diet of the orchidectomized @entity1 decreased the release of @entity8 and ROS, while increasing NO production and the antioxidant capacity, and it also improved the lipid profile. Additionally, it restored the participation of hyperpolarizing mechanisms by activating @entity6 . Since the modifications induced by the @entity10 -supplemented diet were observed in the orchidectomized, but not in the healthy group, @entity10 seems to exert cardioprotective effects in physiopathological situations in which @entity4 exists.

title: Effect of Dietary XXXX Supplementation on the Participation of Vasodilator Factors in Aorta from Orchidectomized @entity1 .

answer: @entity9


abstract: OBJECTIVES: To review outcomes after curative treatment for @entity1 in the Vancouver Island Cancer Centre from 1993 to 1998. Curative treatments included esophagectomy alone, and chemoradiotherapy with "selective surgery" for @entity0 with post-treatment-positive endoscopic biopsy or less than 75% regression on computed axial tomography scan, or with resectable local recurrence. METHODS: @entity0 undergoing esophagectomy alone, or primary chemoradiotherapy and "selective surgery" were reviewed. This was a retrospective, nonrandomized, institutional experience. @entity2 , relief of @entity3 , disease-specific survival rates and prognostic factors were analyzed. RESULTS: Nineteen @entity0 underwent esophagectomy alone. A total of 56 @entity0 underwent primary chemoradiotherapy, of whom 16 had "selective surgery". Relief of @entity3 was similar in both groups of esophagectomy @entity0 . Exploration for "selective surgery" was performed in 12 @entity0 after their first postchemo-radiotherapy endoscopy (two @entity0 had unresectable disease), and in seven for relapse, one of whom died intraoperatively. Overall, the mortality rate due to surgery was 3%. Chemoradiotherapy was not associated with more frequent serious surgical complications. For @entity0 who underwent esophagectomy alone and those who underwent chemoradiotherapy plus selective surgery, the median survival times were 12.9 and 16.4 months, respectively, and the three-year survival rates were 21% and 37%, respectively. Seventeen of 25 @entity0 who underwent chemoradiotherapy and who survived more than two years have not required selective surgery. For the two groups of @entity0 combined, no single prognostic factor for survival was significant in multivariate analysis, but for @entity0 who underwent chemoradiotherapy plus selective surgery, negative endoscopic biopsy was highly significant. CONCLUSIONS: @entity2 and disease-specific survival rates after primary chemoradiotherapy with selective surgery compare favourably with esophagectomy alone in the curative treatment of @entity1 . A prospective, randomized trial is necessary for the definitive evaluation of the strategy of chemoradiotherapy and selective surgery.

title: Curative treatment for XXXX : Vancouver Island Cancer Centre experience from 1993 to 1998.

answer: @entity1


abstract: The term " @entity4 " encompasses the heterogeneous group of diseases caused by the extracellular deposition of autologous fibrillar proteins. The global incidence of @entity4 is estimated at five to nine cases per million @entity0 -years. While @entity5 ( @entity5 ) @entity4 is more frequent in developed countries, @entity2 ( @entity2 ) @entity4 is more common in some European regions and in developing countries. The spectrum of @entity4 has changed in recent decades owing to: an increase in the median age at diagnosis; a percent increase in the frequency of primary @entity4 with respect to the @entity2 type; and a substantial change in the epidemiology of the underlying diseases. Diagnosis of @entity4 is based on clinical organ involvement and histological evidence of @entity1 . Among the many tinctorial characteristics of @entity1 , avidity for Congo red and metachromatic birefringence under unidirectional polarized light remain the gold standard. Once the initial diagnosis has been made, the amyloid subtype must be identified and systemic organ involvement evaluated. In this sense, the (123)I-labeled serum amyloid P component scintigraphy is a safe and noninvasive technique that has revolutionized the diagnosis and monitoring of treatment in @entity3 . It can successfully identify anatomical patterns of @entity1 throughout the body and enables not only an initial estimation of prognosis, but also the monitoring of the course of the disease and the response to treatment. Given the etiologic diversity of @entity4 , common therapeutic strategies are scarce. All treatment options should be based upon a greater control of the underlying disease, adequate organ support, and treatment of symptoms. Nevertheless, novel therapeutic strategies targeting the formation of amyloid fibrils and @entity1 may generate new expectations for @entity0 with @entity4 .

title: XXXX : epidemiology, diagnosis, and management.

answer: @entity3


abstract: BACKGROUND: Circulating @entity3 cells (CTCs) are associated with prognosis in a variety of @entity1 @entity3 and have been proposed as a liquid biopsy for follow-up examinations. We show that @entity3 suppressor and @entity2 suppressor genes are epigenetically silenced in CTCs isolated from peripheral blood of @entity0 @entity1 . METHODS: We obtained peripheral blood from 56 @entity1 with operable @entity0 , 27 @entity1 with verified @entity2 , and 23 healthy individuals. We tested DNA extracted from the EpCAM-positive immunomagnetically selected CTC fraction for the presence of methylated and unmethylated @entity7 , @entity6 , and @entity5 promoter sequences by methylation-specific PCR (MSP). All samples were checked for @entity4 ( @entity4 , formerly @entity4 ) expression by reverse-transcription quantitative PCR. RESULTS: In CTCs of @entity1 with operable @entity0 , promoter methylation of @entity7 was observed in 17.9%, @entity6 in 32.1%, and @entity5 in 53.6% of @entity1 . In CTCs of @entity1 with verified @entity2 , promoter methylation of @entity7 was observed in 37.0%, @entity6 in 44.4%, and @entity5 in 74.1%. In healthy individuals, promoter methylation of @entity7 was observed in 4.3%, @entity6 in 8.7%, and @entity5 in 4.3%. DNA methylation of these genes for both operable and metastatic @entity0 was significantly different from that of the control population. CONCLUSIONS: DNA methylation of @entity3 suppressor and @entity2 suppressor genes is a hallmark of CTCs and confirms their heterogeneity. Our findings add a new dimension to the molecular characterization of CTCs and may underlie the acquisition of malignant properties, including their stem-like phenotype.

title: DNA methylation of XXXX suppressor and @entity2 suppressor genes in circulating @entity3 cells.

answer: @entity3