abstract: Case Description-A 16-year-old 6.8-kg (15-lb) castrated male domestic shorthair cat was evaluated because of a 3 * 6-cm mass in the right medial lobe of the liver. Clinical Findings-The cat had a history of frequent @entity4 and @entity5 along with 10% weight loss over the past year. Treatment and @entity7 was selected because surgery (standard first-line treatment) was declined and only 1 vessel feeding the @entity0 was apparent on contrast-enhanced CT. A 4F sheath was placed in the left carotid artery, and a 3.3F guide catheter was advanced into the celiac artery. A 0.014-inch guidewire and 1.7F microcatheter were inserted into the hepatic artery through the guiding catheter and advanced into the feeding vessel. A mixture of @entity8 particles and contrast agent was injected for embolization. A hypoechoic area in the @entity0 was identified on ultrasonography on posttreatment day 6, and @entity1 and degenerated cells in the area were identified cytologically. By posttreatment day 71, @entity4 had resolved and CT revealed @entity0 size, but altered attenuation suggested a more solid mass on day 205. No feeding vessel for embolization was found on contrast-enhanced CT, so ultrasonic emulsification to remove the @entity0 was performed on day 231. No recurrence was seen on contrast-enhanced CT on day 420 or day 721. Clinical Relevance-Findings suggested that transcatheter @entity7 may be suitable for treating @entity2 in @entity6 , but alternative approaches are needed in @entity6 , compared with @entity3 , owing to anatomic differences.

title: Transcatheter XXXX for treatment of hepatocellular carcinoma in a cat.

answer: @entity7


abstract: @entity0 noroviruses (NoV) are the leading cause of @entity3 worldwide. Epidemiological studies of outbreaks have suggested that @entity2 facilitates transmission of @entity0 NoV, but there have been no laboratory-based studies characterizing the degree of NoV release during a @entity2 event. The purpose of this work was to demonstrate that virus aerosolization occurs in a simulated @entity2 event, and to estimate the amount of virus that is released in those aerosols. A simulated @entity2 device was constructed at one-quarter scale of the @entity0 body following similitude principles. Simulated vomitus matrices at low (6.24 mPa*s) and high (177.5 mPa*s) viscosities were inoculated with low (108 PFU/mL) and high (1010 PFU/mL) concentrations of bacteriophage @entity5 and placed in the artificial "stomach" of the device, which was then subjected to scaled physiologically relevant pressures associated with @entity2 . Bio aerosols were captured using an SKC Biosampler. In @entity1 , there were notable differences between recovered aerosolized @entity5 as a function of pressure (i.e., greater aerosolization with increased pressure), although this was not always statistically significant. This relationship disappeared when using high viscosity simulated vomitus. The amount of @entity5 aerosolized as a @entity4 " ranged from 7.2 x 10-5 to 2.67 x 10-2 (which corresponded to a range of 36 to 13,350 PFU total). To our knowledge, this is the first study to document and measure aerosolization of a NoV surrogate in a similitude-based physical model. This has implications for better understanding the transmission dynamics of @entity0 NoV and for risk modeling purposes, both of which can help in designing effective infection control measures.

title: Aerosolization of a @entity0 Norovirus Surrogate, Bacteriophage XXXX , during Simulated Vomiting.

answer: @entity5


abstract: BACKGROUND: @entity1 ( @entity1 )-induced @entity6 involves disruption of endothelial cell adherens junctions leading to increase in paracellular permeability. b-Catenin, an integral component of the adherens junctional complex and Wnt pathway, and @entity4 via its apoptotic signaling regulate endothelial cell barrier integrity. We have hypothesized that inhibiting phosphorylation of b-catenin and @entity4 activity using glycogen synthase kinase 3-specific inhibitor @entity7 would attenuate @entity6 following @entity1 . METHODS: In @entity0 , @entity1 was induced by withdrawing blood to reduce mean arterial pressure to 40 mm Hg for 60 minutes followed by resuscitation. @entity0 were given @entity7 (600  g/kg) intravenously 10 minutes before shock. To study microvascular permeability, the @entity0 were intravenously injected with @entity2 ( @entity3 )-albumin (50 mg/kg), and its flux across the mesenteric postcapillary venules was determined using intravital microscopy. In cell culture studies, @entity0 lung microvascular endothelial cell monolayers grown on Transwell plates were pretreated with @entity7 (5  M) followed by BAK (5  g/mL) and @entity4 (5  g/mL) protein transfection. @entity3 -albumin (5 mg/mL) flux across cell monolayers indicates change in monolayer permeability. Activity of canonical Wnt pathway was determined by luciferase assay. @entity4 enzyme activity was assayed fluorometrically. RESULTS: The @entity1 group showed significant increase in @entity3 -albumin extravasation (p < 0.05) compared with sham. @entity7 significantly decrease @entity1 -induced @entity3 -albumin extravasation (p < 0.05). Pretreatment with @entity7 protected against a BAK-induced increase in @entity0 lung microvascular endothelial cell monolayer permeability and @entity4 activity but failed to show similar results with a @entity4 -induced increase in monolayer permeability. @entity5 treatment showed an increase in b-catenin-dependent T-cell factor-mediated transcription. CONCLUSION: Inhibiting phosphorylation of b-catenin and @entity4 activity using glycogen synthase kinase 3-specific inhibitor @entity7 help regulates @entity1 -induced @entity6 .

title: Glycogen synthase kinase 3 inhibitor protects against @entity6 following XXXX .

answer: @entity1


abstract: The incidence of @entity1 among 4480 shipyard workers, including 861 welders, was investigated for a potential relationship between exposure to welding fumes and @entity0 . A subcohort of 3150 workers with information on previous work history was studied separately. This investigation is a historical prospective cohort study. Environmental air samples were collected in 1973, 1977, and 1989. Information on smoking habits was surveyed in 1976 and 1984. The employment work histories were collected from the personnel register. There were 411 observed cancers of all sites versus 387.5 expected, and 45 cases of @entity0 versus 51.3 expected. Nine cases of @entity0 were found among the welders versus 7.1 expected. Among 310 former seamen with welding experience, there was 1 case of @entity0 versus 2.1 expected. These shipyard workers showed no excess risk of @entity0 . @entity2 smoking and asbestos exposure are potential confounders in the study. There was no clear relationship between exposure to welding fumes and @entity0 , but welders with the longest experience had a relative risk of 1.9 for @entity0 . The differences in @entity0 incidence among the different shipyard workers could not be attributed to differences in recruitment patterns or previous work history.

title: Incidence of XXXX among welders and other shipyard workers with information on previous work history.

answer: @entity1


abstract: PURPOSE: Intergroup Study 0114 was designed to study the effect of various chemotherapy regimens delivered after potentially curative surgical resection of T3, T4, and/or node-positive @entity1 . A subset analysis was undertaken to investigate the prevalence and influence of salvage therapy among @entity0 with recurrent disease. @entity0 AND METHODS: Adjuvant therapy consisted of two cycles of @entity2 (FU)-based chemotherapy followed by pelvic irradiation with chemotherapy and two more cycles of chemotherapy after radiation therapy. A total of 1,792 @entity0 were entered onto the study and 1,696 were assessable. After a median of 8.9 years of follow-up, 715 @entity0 (42%) had disease recurrence, and an additional 10% died without evidence of disease. Five hundred @entity0 with follow-up information available had a single organ or single site of first recurrence (73.5% of all recurrences). RESULTS: A total of 171 @entity0 (34% of those with a single organ or single site of recurrence) had a potentially curative resection of the metastatic or locally recurrent disease. Single-site first recurrences in the liver, lung, or pelvis occurred in 448 @entity0 (90% of the single-site recurrences), with 159 (35%) of these undergoing surgical resection for attempted cure. Overall survival differed significantly between the resected and nonresected groups (P <.0001), with overall 5-year probabilities of.27 and.06, respectively. Controlling for worst performance status at the time of recurrence does not alter this relationship. @entity0 who underwent salvage surgery had significantly increased survival (P <.001) for each site. CONCLUSION: Attempted surgical salvage of @entity1 recurrence is performed commonly in the United States. The chance of a long-term cure with such intervention is approximately 27%.

title: Analysis of surgical salvage after failure of primary therapy in XXXX : results from Intergroup Study 0114.

answer: @entity1


abstract: @entity1 receptors (NMDARs) are tetrameric protein complexes usually comprising two @entity6 and two NR2 subunits. Different combinations of four potential NR2 subunits (NR2A-D) confer diversity in developmental expression, subsynaptic localization, and functional characteristics, including affinity for neurotransmitter. @entity5 -containing NMDARs, for example, exhibit relatively high affinity both for @entity2 and the coagonist @entity3 . Although multiple NMDAR subtypes can colocalize at individual synapses, particular subtypes often mediate inputs from distinct functional pathways. In @entity4 cells (RGCs), NMDARs contribute to synaptic responses elicited by light stimulus onset ("ON") and offset ("OFF"), but roles for particular NMDAR subtypes, and potential segregation between the ON and OFF pathways, have not been explored. Moreover, elements in the retinal circuitry release two different NMDAR coagonists, @entity3 and @entity7 , but the effects of endogenous coagonist release on the relative contribution of different NMDAR subtypes are unclear. Here, we show that coagonist release within the retina modulates the relative contribution of different NMDARs in the ON pathway of the @entity0 retina. By pharmacologically stimulating functional pathways independently in acute slices and recording synaptic responses in RGCs, we show that ON inputs, but not OFF inputs, are mediated in part by NMDARs exhibiting @entity5 -like pharmacology. Furthermore, suppressing release of NMDAR coagonist reduces NMDAR activation at ON synapses and increases the relative contribution of these putative @entity5 -containing receptors. These results demonstrate direct evidence for evoked coagonist release onto NMDARs and indicate that modulating coagonist release may regulate the relative activation of different NMDAR subtypes in the ON pathway.

title: Coagonist release modulates @entity1 receptor subtype contributions at synaptic inputs to XXXX cells.

answer: @entity4


abstract: @entity8 is one cause of @entity3 , a condition in which there is @entity7 and dysregulated hypersecretion of @entity5 . In normal, and in some @entity1 parathyroid cells, @entity5 secretion is mediated by the cell surface @entity4 -sensing receptor. We describe the first therapeutic use of a novel molecule, a calcimimetic, that has agonist action at the @entity4 -sensing receptor. A 78-yr-old @entity0 with @entity8 was admitted with @entity7 , markedly elevated @entity5 , and a change in mental status. He was treated for 17 days with conventional therapy, which included saline hydration, @entity6 , @entity9 , and @entity2 . This was ineffective, and on hospital day 18, calcimimetic at a dose of 50 mg, orally, every 6 h was added. On hospital day 25, the dose was increased to 100 mg, orally, every 6 h, and on hospital day 30, saline and @entity6 were discontinued. He was discharged on hospital day 40. With several dose adjustments, he has been treated with monotherapy calcimimetic for over 600 days and has not required any other interventions for his @entity8 . Mean daily precalcimimetic treatment values of serum ionized @entity4 and @entity5 were 1.83 mmol/L and 872 pg/mL, respectively. During hospitalization, at the lower dose of calcimimetic, @entity4 and @entity5 decreased to 1.67 mmol/L and 538 pg/mL; with the higher dose they further decreased to 1.51 mmol/L and 444 pg/mL. Since discharge, and despite increasing levels of @entity5 , serum @entity4 has remained high, but lower than the admission level and acutely responsive to changes in calcimimetic doses. This compound, a calcimimetic, the first of a new class of compounds with activity at the @entity4 -sensing receptor, has been used to treat a @entity0 with @entity8 . During 2 yr of treatment, no adverse clinical effects have been observed, and it appears to have been effective at controlling @entity7 .

title: Treatment of @entity7 secondary to XXXX with a novel calcimimetic agent.

answer: @entity8


abstract: BACKGROUND: Poor participation rates are often observed in @entity1 ( @entity1 ) screening programs utilising faecal occult blood tests. This may be from dislike of faecal sampling, or having benign bleeding conditions that can interfere with test results. These barriers may be circumvented by offering a blood-based DNA test for screening. The aim was to determine if program participation could be increased by offering a blood test following @entity2 ( @entity2 ) non-participation. MATERIALS AND METHODS: @entity0 were invited into a @entity1 screening study through their General Practice and randomised into control or intervention (n=600/group). Both groups were mailed a @entity2 (matching conventional screening programs). Participation was defined as @entity2 completion within 12wk. Intervention group non- @entity0 were offered a screening blood test (methylated @entity3 / @entity4 ). Overall participation was compared between the groups. RESULTS: After 12wk, @entity2 participation was 82% and 81% in the control and intervention groups. In the intervention 96 @entity2 non- @entity0 were offered the blood test - 22 completed this test and 19 completed the @entity2 instead. Total screening in the intervention group was greater than the control (88% vs 82%, p<0.01). Of 12 invitees who indicated that @entity2 was inappropriate for them (mainly due to bleeding conditions), 10 completed the blood test (83%). CONCLUSIONS: Offering a blood test to @entity2 non- @entity0 increased overall screening participation compared to a conventional @entity2 program. Blood test participation was particularly high in invitees who considered @entity2 to be inappropriate for them. A blood test may be a useful adjunct test within a @entity2 program.

title: Improving Participation in XXXX : a Randomised Controlled Trial of Sequential Offers of Faecal then Blood Based Non-Invasive Tests.

answer: @entity1


abstract: @entity3 not otherwise specified (PTCLs/NOS) are rare and aggressive @entity0 whose molecular pathogenesis and diagnosis are still challenging. The microRNA (miRNA) profile of 23 PTCLs/NOS was generated and compared with that of normal T-lymphocytes (CD4+, CD8+, naive, activated). The differentially expressed miRNA signature was compared with the gene expression profile (GEP) of the same @entity0 . The obtained gene patterns were tested in an independent cohort of PTCLs/NOS. The miRNA profile of PTCLs/NOS then was compared with that of 10 angioimmunoblastic @entity1 (AITLs), 6 @entity2 ( @entity2 )/ @entity4 + and 6 @entity2 / @entity4 -. Differentially expressed miRNAs were validated in an independent set of 20 PTCLs/NOS, 20 AITLs, 19 @entity2 / @entity4 - and 15 @entity2 / @entity4 +. Two hundred and thirty-six miRNAs were found to differentiate PTCLs/NOS from activated T-lymphocytes. To assess which miRNAs impacted on GEP, a multistep analysis was performed, which identified all miRNAs inversely correlated to different potential target genes. One of the most discriminant miRNAs was selected and its expression was found to affect the global GEP of the @entity0 . Moreover, two sets of miRNAs were identified distinguishing PTCL/NOS from AITL and ALCL/ @entity4 -, respectively. The diagnostic accuracy of this tool was very high (83.54%) and its prognostic value validated.

title: Pathogenetic and diagnostic significance of microRNA deregulation in XXXX not otherwise specified.

answer: @entity3


abstract: BACKGROUND: Successful experiences of the Neuroform stent-assisted coiling have been reported by many teams in endovascular neurosurgery centers throughout the world. However, most of the reported complications involved a limited number of @entity0 . OBJECTIVE: To systematically report the complications of Neuroform stent-assisted coiling of @entity4 and to tentatively assess the efficacy and safety of this method. METHODS: A retrospective study of 232 consecutive @entity0 with 239 wide-neck @entity5 treated with Neuroform stent-assisted coil embolization at our institution over a 6-year period was performed. Angiographic results and clinical outcome were evaluated. Cases with complications were analyzed. RESULTS: Stenting was successful in 237 of 239 @entity5 . Favorable clinical outcome (modified Rankin score: 0-2) was observed in 88  3% of the @entity0 . Procedure-related complications included @entity9 (n = 13), intraprocedural @entity2 (n=8), coil protrusions (n=5), new mass effect (n=3), @entity1 (n=3), and stent dislodgement (n=2). Procedure-related morbidity and mortality were 4  2 and 1  3%, respectively. @entity7 attributable to @entity6 in 129 @entity0 with @entity11 were symptomatic @entity12 (18  6%) and shunt-dependent @entity10 (6  9%). Angiography follow-up was obtained in 67  1% of the treated @entity5 . The overall recanalization rate was 14  5%. Delayed complications included in-stent @entity8 (n=2) and penetrating @entity3 (n=2) in follow-up period. CONCLUSION: Neuroform sent-assisted coiling of @entity4 is a safe technique with relatively low recanalization rate. The main cause of morbidity and mortality is @entity9 . Long-term effect on parent artery should be observed carefully.

title: Complications and adverse events associated with Neuroform stent-assisted coiling of wide-neck XXXX .

answer: @entity4


abstract: To describe three @entity0 with recurrent severe @entity14 @entity2 precipitated by @entity13 . @entity5 elicited by @entity13 is a well-recognized clinical phenomenon in @entity0 with @entity1 , @entity7 and @entity12 . Clinical history, neurological and oral examinations, brain magnetic resonance imaging (MRI), cranial nerve electrophysiological testing and skull X-rays are reported. In all the @entity0 @entity5 was induced by @entity13 ; in the third @entity0 @entity5 was also triggered by eructation. None had history of @entity10 . @entity8 and forceful opening of the mouth did not reproduce the @entity5 . The first @entity0 had @entity5 , @entity11 -induced @entity4 and subclinical @entity9 ; the second @entity0 had a post-viral @entity3 ; and the third had @entity5 and no underlying @entity3 . Cranial nerve testing and MRI of the brain were normal except for a coincidentally found @entity6 on the first @entity0 . @entity2 or @entity2 with @entity13 may occur in @entity0 with no apparent cause (primary @entity13 @entity2 ). It is a chronic, benign condition that requires no specific treatment but needs to be distinguished from secondary @entity13 @entity2 , of greater clinical relevance.

title: Primary XXXX @entity2 .

answer: @entity13


abstract: PURPOSE: The purpose of this study was: 1) to determine variables that might characterize good or bad sleep; and 2) to describe the relationship between sleep, @entity1 , personal function factors, and quality of life based on quality of sleep in @entity0 with @entity4 ( @entity4 ). METHODS: This cross-sectional descriptive study included 224 consecutive @entity0 diagnosed at a specialist center. These @entity0 were mailed a questionnaire concerning sleep, body functions, personal factors, and health-related quality of life. In total, 145 completed questionnaires were collected. RESULTS: Using sleep variables (sleep quality, waking up unrefreshed, and tiredness when getting up), we identified two subgroups - the good sleep subgroup and the bad sleep subgroup - of @entity0 with @entity4 . These subgroups exhibited significantly different characteristics concerning @entity3 intensity, psychological variables (depressed mood, @entity2 , @entity5 , and self-efficacy), @entity1 , and generic and health-related quality of life. The good sleep subgroup reported a significantly better situation, including higher employment/study rate. The bad sleep subgroup reported a greater use of sleep medication. Five variables determined inclusion into either a good sleep or a bad sleep subgroup: @entity3 in the evening, self-efficacy, @entity2 , and according to the Short Form health survey role emotional and physical functioning. CONCLUSION: This study found that it was possible to identify two subgroups of @entity0 with @entity4 based on quality of sleep variables. The two subgroups differed significantly with respect to @entity3 , @entity1 of body functions, and perceived quality of life, where the subgroup with bad sleep had a worse situation.

title: Self-reported nonrestorative sleep in XXXX - relationship to @entity1 , personal function factors, and quality of life.

answer: @entity4


abstract: BACKGROUND: There are only limited data regarding @entity4 from @entity3 . Therefore, we analyzed large series of @entity3 with @entity4 and analyzed their clinical characteristics and treatment outcome to enhance perception of metastatic @entity3 . METHODS: Of 20,187 advanced @entity3 @entity0 treated between 1995 and 2007, 193 (0.96%) were identified to have @entity4 from @entity3 . The @entity4 were detected at chest computed tomography (CT) scan or plain chest X-ray and/or abdominal pelvic CT scan covering the lower part of the lungs, and were divided into three patterns: lymphangitic, hematogenous, and pleural. RESULTS: The most frequently observed pattern of lung @entity1 was hematogenous @entity1 (52.3%) followed by pleural (35.2%) and lymphangitic (26.4%). @entity0 who had @entity4 were significantly associated with hepatic @entity1 (p = 0.004) and male sex (p = 0.012). @entity0 with lymphangitic @entity1 were significantly associated with concomitant bone (p = 0.010) and bone marrow (p = 0.029) @entity1 . In case of @entity1 , it was positively correlated with gastrectomy history (p = 0.015) and the presence of peritoneal @entity1 (p = 0.020). After a median follow-up duration of 87 (9-162) months, the median survival after diagnosis of @entity4 was 4 (0-67) months. CONCLUSION: The most frequently observed pattern of lung @entity1 was hematogenous @entity1 (52.3%) followed by pleural (35.2%) and lymphangitic (26.4%) in @entity3 @entity0 . Among @entity3 @entity0 with lung metastases, @entity0 with @entity1 or lymphangitic @entity1 had shorter survival with 1.5-2-fold increased risk of @entity2 .

title: Lung metastases in metastatic XXXX : pattern of lung metastases and clinical outcome.

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to describe the clinical and radiological findings of @entity0 with @entity8 and @entity7 . Possible mechanisms predisposing these individuals to @entity2 are discussed. METHODS: We retrospectively analyzed 12 consecutive @entity0 with both @entity8 and @entity7 . Moyamoya @entity4 was diagnosed by digital subtract angiography or magnetic resonance angiography (MRA). The clinical characteristics, laboratory data, vascular radiological characteristics and outcome were reported. RESULTS: All @entity0 were female and mean age was 33.33  12.65 years. @entity5 or @entity3 of bilateral terminal internal carotid artery and/or proximal anterior/middle cerebral arteries was found in nine @entity0 . Among them, three @entity0 displayed asymmetrical @entity5 . In addition, there were three @entity0 with probable @entity9 . Eleven @entity0 presented with @entity2 and/or @entity1 ( @entity1 ) and one with @entity6 . Thyroid function tests demonstrated elevated thyroid hormone levels and suppressed thyroid stimulating hormone levels in all the @entity0 with @entity1 events. All patients received anti-thyroid therapy and two had recurrent @entity1 after drug withdrawal. CONCLUSIONS: @entity8 associated @entity7 often presented with asymmetric @entity5 or @entity3 . We hypothesize cerebrovascular hemodynamic changes due to @entity7 contribute to the @entity1 events.

title: @entity8 associated with XXXX : a case series study.

answer: @entity7


abstract: OBJECTIVE: Preterm birth is associated with lower cognitive functioning. One potential pathway is postnatal parental @entity1 . The authors assessed @entity1 in mothers and fathers after @entity2 , and identified the impacts of both prematurity and @entity1 on @entity0 's early cognitive function. METHOD: Data were from the nationally representative Early Childhood Longitudinal Study, Birth Cohort (n = 5350). @entity1 at 9 months were assessed by the Center for Epidemiologic Studies Depression Scale (CESD) and @entity0 's cognitive function at 24 months by the Bayley Short Form, Research Edition. Weighted generalized estimating equation models examined the extent to which @entity2 , and mothers' and fathers' @entity1 impacted @entity0 's cognitive function at 24 months, and whether the association between @entity2 and 24-month cognitive function was mediated by @entity1 . RESULTS: At 9 months, fathers of very preterm (<32 weeks gestation) and moderate/late preterm (32-37 weeks gestation) @entity0 had higher CESD scores than fathers of term-born (>= 37 weeks gestation) @entity0 (p value = .02); @entity2 was not associated with @entity1 . In multivariable analyses, @entity2 was associated with lower cognitive function at 24 months; this association was unaffected by adjustment for @entity1 . Fathers', but not mothers', @entity1 predicted lower cognitive function in the fully adjusted model (b = -0.11, 95% confidence interval, -0.18 to -0.03). CONCLUSION: Fathers of preterm @entity0 have more postnatal @entity1 symptomology than fathers of term-born @entity0 . Fathers' @entity1 also negatively impact @entity0 's early cognitive function. The national findings support early identification and treatment of fathers of preterm @entity0 with @entity1 .

title: Postnatal Depressive Symptoms Among Mothers and Fathers of XXXX Born Preterm: Prevalence and Impacts on @entity0 's Early Cognitive Function.

answer: @entity0


abstract: OBJECTIVE: The present study investigated the associations of stature, lower leg length (LLL) and demi-arm span (demi- @entity10 ) with major predisposing @entity2 factors and @entity7 . STUDY DESIGN AND SUBJECTS: Cross-sectional study set at Glasgow Royal Infirmary of a subsample of 543 @entity0 and 646 @entity0 aged 25-66 y from the random MONICA sample. ASSOCIATED MEASURES: LLL, demi- @entity10 , blood pressure, plasma total @entity4 , @entity1 and @entity7 ( @entity9 , angioplasty, @entity6 , and coronary artery bypass graft). RESULTS: The numbers (and proportions) of @entity0 and @entity0 , respectively, with @entity3 were 126 (23.6%) and 80 (14.0%), hypercholesterolaemia 155 (29.0%) and 171 (30.1%), @entity7 53 (10.1%) and 47 (8.4%), and @entity1 15 (2.9%) and 9 (1.6%). Results were adjusted for age, social class and smoking. Analysis of variance showed that in @entity0 , @entity8 of height, LLL or demi- @entity10 were all associated significantly (P < 0.05) with hypercholesterolaemia. Long LLL, high ratios of LLL:height or LLL:demi-As were associated significantly (P < 0.05) with @entity1 . In @entity0 , @entity8 of height or LLL were associated with significantly (P < 0.05) with @entity7 . High ratio of demi- @entity10 :height or low ratio of LLL:demi- @entity10 was associated significantly (P < 0.05) with @entity7 . CONCLUSIONS: @entity8 and limb lengths, and also altered skeletal proportions, which may reflect interrupted early growth, are associated with several @entity5 . Skeletal disproportion associates with @entity1 in @entity0 and @entity7 in @entity0 .

title: Skeletal proportions and XXXX in adults.

answer: @entity5


abstract: OBJECTIVE: This study aimed to determine the effect of various suturing techniques on the regularity of postkeratoplasty @entity1 . DESIGN: A prospective clinical trial. @entity0 : Sixty-two consecutive @entity0 undergoing penetrating keratoplasty by the same surgeon (MB) participated. INTERVENTION: Each @entity0 was assigned to one of four groups according to the suturing technique used (a = 16 interrupted 10-0 nylon sutures; b = 2 running 10-0 nylon sutures, each with 8 bites; c = 2 running 10-0 nylon sutures, each with 12 bites; d = 2 running 10-0 nylon sutures, each with 16 bites). This was the only parameter permitted to be changed in the standard keratoplasty procedure used for all cases. Corneal topography was performed 1, 3, and 6 months after surgery. The astigmatic patterns seen on the corneal maps then were classified into regular (symmetric or asymmetric bowtie patterns) or irregular (distorted bowtie, multiaxial, or other patterns). MAIN OUTCOME MEASURES: Regularity of postkeratoplasty corneal @entity1 was measured. RESULTS: At all postoperative examination times, the percentage of irregular astigmatic patterns was highest in group a and lowest in group d (chi-square test: P < 0.005). Groups b and c showed intermediate values. The entity of the astigmatic error as measured by the simulated K-readings of the topographic maps did not differ significantly in the four groups. CONCLUSIONS: A suturing technique using 2 running sutures with 16 bites each can minimize irregular postkeratoplasty @entity1 as long as sutures are in place, when compared with interrupted sutures or double-running sutures of less than 16 bites.

title: Different suturing techniques variously affect the regularity of postkeratoplasty XXXX .

answer: @entity1


abstract: PURPOSE: @entity3 ( @entity3 ) is a life-limiting @entity2 that presents as an elevated blood pressure in the pulmonary artery. The uncertainty of the disease has a profound effect on relationships, @entity1 , spirituality, emotions, and exercise ability and can negatively impact health-related quality of life (HRQOL). The purposes of this cross-sectional, predictive, correlational study were (a) to identify relationships among the psychological factors ( @entity6 , @entity5 , stress), physiological factor (6-Minute Walk Test), situational factor (social support), and HRQOL and (b) to test a structural equation model in which @entity6 , @entity5 , stress, social support, and 6-minute walk distance predict HRQOL in adults with @entity3 . SAMPLE AND SETTING: A convenience sample of 166 adults between the ages of 21 and 80 years were recruited from the @entity3 Association's 10th International @entity3 Conference and Scientific Sessions in Orlando, Florida, and a @entity3 clinic in southeast Louisiana. Each subject completed 2 questionnaires: the 21-item Depression Anxiety Stress Scale and the Dartmouth Cooperative Functional Assessment Charts. RESULTS: The findings indicated a relationship between @entity6 , stress, @entity5 , 6-Minute Walk Test, social support, and HRQOL. The data collected from the adult @entity3 population fit the proposed predictive model for adults with @entity3 HRQOL. However, the researcher was unable to determine the best predictor of HRQOL in adults with @entity3 . CONCLUSIONS: The findings indicate @entity6 , @entity5 , stress, 6-minute walk distance, and social support play important roles in HRQOL among @entity0 with @entity3 . Advanced practice nursing strategies to increase HRQOL include counseling, @entity4 referrals, psychotherapy, guided imagery, leading support groups, and low-grade resistance training.

title: A predictive model of the effects of XXXX , @entity5 , stress, 6-minute-walk distance, and social support on health-related quality of life in an adult pulmonary hypertension population.

answer: @entity6


abstract: @entity14 ( @entity14 ) type II can be seen as late onset form with @entity2 phenotype. We present a case of a 19-year old female with progressive @entity5 was admitted in intensive care unit (ICU) with @entity8 and @entity6 . @entity0 was unconscious. Pupils were anisocoric and light reflex was absent. She had @entity3 . The laboratory results showed a @entity4 level of 70  mg/dl and the liver enzymes were high. The @entity0 also had @entity9 (117  mEq/L) and @entity7 level of 3.9  mmol/L. Tandem @entity1 and organic acid analysis were compatible with @entity14 type II. @entity10 1gr, @entity12 100  mg and @entity11 100  mg was arranged. After four months from beginning of treatment tandem @entity1 results are improved. @entity8 , @entity6 due to profound @entity2 can be due to @entity13 that responded rapidly to appropriate therapy.

title: XXXX presenting with @entity8 in an adult.

answer: @entity13


abstract: A 5-year-old @entity0 presented with @entity4 . His maxillary and mandibular incisors were within normal limits. The premolar/molar areas in all quadrants were occupied by markedly macrodontic teeth showing globular shape. The @entity1 had a similar rounded shape. Two @entity1 and 1 of the other abnormal teeth demonstrated areas of yellow hypoplastic enamel. Radiographs revealed that some of the abnormal teeth had bifurcated pulp chambers and @entity3 . Premolar tooth germs were absent. Audiometry demonstrated that the @entity0 had a marked bilateral @entity2 for frequencies above 1000 Hz. No other members of the immediate family were clinically affected. The parents of the @entity0 were not aware of any similarly affected relatives. Suggestions with respect to possible genetic mechanisms and gene participation in the etiology of this syndrome are offered.

title: XXXX : a case report and genetic considerations.

answer: @entity4


abstract: OBJECTIVE: To evaluate a contribution of selected laboratory parameters for a prediction of progressive and erosive development in @entity0 with early @entity2 ( @entity2 ). METHODS: In a prospective study baseline levels of antibodies to cyclic citrullinated peptide (anti-CCP), IgM, IgA, and IgG rheumatoid factors (RFs) were measured by enzyme linked immunosorbent assay (ELISA) in 104 @entity0 with @entity2 with disease duration <2 years. Antikeratin antibodies (AKA) and antiperinuclear factor (APF) were detected by indirect immunofluorescence. @entity0 were divided into two groups based either on the presence or absence of erosions or according to progression of Larsen score at the end of the 24 months' follow up. RESULTS: Sixty seven (64%) @entity0 developed radiographic erosions, 49 (47%) had progression in Larsen score, and 36 (35%) progressed by more than 10 Larsen units. Significant differences in erosions and progression between the two groups were detected for anti-CCP, AKA, APF, IgM RF, IgA RF, and IgG RF. Baseline Larsen score correlated significantly with anti-CCP, IgM RF, and IgA RF levels, and all measured antibodies correlated with the progression >10 units. The combination of anti-CCP and IgM RF increased the ability to predict @entity1 . CONCLUSION: The data confirmed that measurement of anti-CCP, AKA, APF, and individual isotypes of RFs was useful for prediction of structural damage early in the disease course. Combined analysis of anti-CCP and IgM RF provides the most accurate prediction.

title: Autoantibodies can be prognostic markers of an erosive disease in early XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity4 characterized by @entity2 and @entity6 . The presence of @entity7 along with @entity3 during @entity5 in @entity0 with @entity4 has not been described previously. METHODS AND RESULTS: Two female @entity0 (18 and 16 years old) with recurrent @entity7 at the time of @entity5 are described. @entity0 1 had recurrent episodes of @entity5 . During one of these episodes, which occurred while she was being monitored, @entity7 along with high-grade @entity3 was seen at the time of @entity5 and @entity2 . @entity0 2 had a history of recurrent @entity5 and @entity1 . During one of these episodes, she was documented to have ventricular asystole lasting for about 39 seconds. The sinus rate was 480 msec at the beginning, before slowing down to 960 msec prior to restoration of sinus rhythm with 1:1 AV conduction. The same scenario was repeated during head-up tilt testing. Both @entity0 were treated successfully with oral @entity8 and, during a follow-up of 28 months and 9 months, have remained symptom-free. CONCLUSION: Sinus acceleration along with high-grade @entity3 during @entity5 and @entity2 can occur in some @entity0 with @entity4 . The exact mechanism of this phenomenon is unclear.

title: XXXX with @entity3 : an unusual presentation during @entity4 .

answer: @entity7


abstract: BACKGROUND: @entity11 ( @entity11 ) is expressed in upper airways, however, little is known regarding whether @entity11 ( @entity11 ) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with @entity3 (CRSwNP), especially on @entity0 . We sought to investigate the effect of Poly(IC), the ligand for @entity11 , on cytokine production by dispersed nasal polyp cells (DNPCs). METHODS: DNPCs were pretreated with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of @entity1 , @entity4 , @entity9 , @entity10 and @entity2 in the supernatant were measured. To determine the involvement of @entity4 and cyclooxygenase in Poly(IC)-mediated signaling, DNPCs were treated with anti- @entity4 monoclonal antibody and @entity8 , the cyclooxygenase inhibitor, respectively. @entity12 -induced @entity5 ( @entity5 ) production was also determined. RESULTS: Exposure to @entity12 induced a significant production of @entity4 , but not of @entity1 , @entity9 , @entity10 or @entity2 by DNPCs. Pretreatment with @entity12 dose-dependently inhibited SEB-induced @entity1 , @entity9 and @entity10 , but not @entity2 production. Neutralization of @entity4 significantly abrogated the inhibitory effect of @entity12 . Treatment with @entity8 also abrogated the inhibitory effect of @entity12 on SEB-induced @entity1 and @entity9 production. However, unlike exposure of @entity8 -treated DNPCs to lipopolysaccharide, the ligand for @entity7 , exposure of these cells to @entity12 did not enhance @entity1 or @entity9 production. Poly(IC) did not significantly increase @entity5 production by DNPCs. CONCLUSIONS: These results suggest that @entity11 signaling regulates @entity6 -associated cytokine production in CRSwNP, at least in part, via @entity4 production.

title: Regulatory effect of @entity11 signaling on staphylococcal enterotoxin-induced @entity1 , @entity9 , XXXX and @entity2 production in chronic rhinosinusitis with @entity3 .

answer: @entity10


abstract: OBJECTIVE: To investigate the occurrence, genetic inheritance, and @entity1 conditions of @entity6 ( @entity6 ), and to measure the width of external aperture of vestibular aqueduct (VA) of @entity6 , and to analyze the relationship between the @entity1 and the width of external aperture. METHODS: A retrospective review was conducted by the history, auditory, and vestibular function examinations in 95 @entity0 (190 ears) of @entity6 . The width of VA was measured by CT scanning criterion of each @entity6 @entity0 in the past 10 years (from 1992 to 2002). RESULTS: In 95 @entity0 , there were male 65 cases and female 30 cases. The male cases was more than the females by a ratio of 2.2:1. Twelve cases (12.6%) would have familial genetic history. The average of the consult age was 7.6 years (range from 1.2 to 39 years). The most @entity0 were misdiagnosed, the @entity1 originated from mild @entity2 in 21 cases (22.1%), the @entity1 after common cold in 13 cases (13.6%). Nine cases (9.5%) misdiagnosed as @entity4 , 5 cases (5.3%) as @entity3 @entity1 of @entity5 antibiotic. The profound @entity1 was found in 172 ears (92.4%). The average width of external aperture of @entity6 was 7.5 mm +/- 1.2 mm (mean +/- s, 77 cases, 154 ears). The level of @entity1 did not proportional to the width of VA. The @entity1 could be derived from protein-rich endolymph refluxed into the cochlear and vestibule. CONCLUSION: The @entity6 is distinct clinical entity characterized by fluctuate and progressive SNHL. The diagnosis depends upon the CT scan and MR image. If the hearing fluctuated and subsequently improved, the @entity0 were kept under conservation treatment. If the significantly decreased of hearing effected school performance, the cochlear implant might be considered.

title: [Clinical analysis of 95 @entity0 with XXXX ].

answer: @entity6


abstract: UNASSIGNED: Resistance of @entity0 to radiotherapy and/or chemotherapy is one of the important reasons of clinical treatment failure and recurrence. Chemoradiation is an optional method to over-coming of radioresistance and chemoresistance. @entity3 nanoparticles (SeNPs) with special chemical and physical properties, has been identified as a novel nanocarrier and therapy agent with broad-spectrum anticancer activities due to generate ROS in cells. Herein, X-ray responsive @entity3 nanoparticles were facilely fabricated by using @entity2 as surface decorator and template. This nanosystem ( @entity2 -SeNPs) demonstrated X-ray responsive property that was attributed to its amorphous characteristic. Interestingly, the nanosystem demonstrated significant radiosensitization effects with X-ray. Specifically, co-treatment of @entity0 cells with @entity2 -SeNPs and X-ray significantly and synergistically enhanced the cells growth inhibition through induction of cell apoptosis, as evidenced by DNA fragmentation and activation of @entity1 . In the cell model, we found that internalized nanoparticles could degrade upon X-ray exposure, which further confirm the X-ray responsive property of the nanoparticles. Moreover, the nanosystem could significantly induced intracellular ROS generation in a time-dependent manner, which peaked at about 40min and gradually decreased thereafter. As a results, ROS overproduction led to mitochondria fragmentation and the cell apoptosis. Taken together, this study provides a novel strategy for rational design and facile synthesis of chemo-radio therapeutic radiosensitization nanomaterials.

title: X-ray-responsive XXXX nanoparticles for enhanced @entity0 chemo-radiotherapy.

answer: @entity3


abstract: UNASSIGNED: 7237 Background: The purpose of this study was to determine maximum tolerated dose (MTD) and the dose-limiting @entity2 (DLT) of a combination of @entity1 plus @entity4 administration in a biweekly schedule for inoperable @entity3 . METHODS: @entity0 with inoperable stages IIIB and IV @entity3 included in this study were treated with @entity4 followed by @entity1 . @entity4 was given intravenously over 30 minutes, and @entity1 was given intravenously over 30 minutes. RESULTS: Fifteen @entity0 were treated at 4 dose levels. As DLT, treatment delay occurred at dose level 4 in 2 of the 6 @entity0 . No DLT was experienced in dose levels 1, 2, and 3. No other grade 3/4 @entity2 was observed. Twelve @entity0 were available for evaluation of efficacy. Four @entity0 achieved partial response. CONCLUSIONS: MTD was not reached in this study. Considering the treatment continuation, the recommended dose for phase II study is @entity4 AUC 3 and @entity1 1000mg/m(2) administration every 2 weeks. [Figure: see text] No significant financial relationships to disclose.

title: A phase I study of biweekly combination chemotherapy with @entity1 (GEM) and @entity4 ( @entity4 ) for inoperable stages IIIB and XXXX ( @entity3 ).

answer: @entity3


abstract: PURPOSE OF REVIEW: To review and evaluate the medical literature on new treatments for periocular infantile (capillary) @entity6 . Recent studies have shown a promising new therapy for @entity10 using nonselective b-blockers, including oral @entity5 and topical @entity9 . RECENT FINDINGS: Conventional treatments for @entity10 include the use of @entity1 , laser, surgery, and immunomodulator therapy. Recently, systemic and topical b-blockers have been used to successfully treat @entity10 . The drugs' mechanism of action remains uncertain, but plausible theories include vasoconstriction, modulation of pro-survival signal transduction pathways, and endothelial cell apoptosis. Whereas no life-threatening adverse events from b-blocker treatment have been described, there have been reports of @entity4 , @entity3 , @entity8 , @entity7 , and electrolyte disturbances resulting from systemic use of @entity5 to treat @entity10 . Sleep and @entity2 have also been frequently reported. Topical timolol application for localized, superficial @entity0 may confer similar efficacy as oral @entity5 while reducing systemic effects. SUMMARY: Despite the recent explosion of interest surrounding this novel treatment, current treatment and protocol-monitoring recommendations are based largely on the experience of individual centers. Several randomized controlled studies are currently underway, the results of which will guide future standard-of-care treatment for @entity10 .

title: Current concepts in the management of periocular infantile (capillary) XXXX .

answer: @entity6


abstract: PURPOSE: To date, @entity1 -based or fluoropyrimidine-based regimens are recommended for unresectable advanced @entity4 . Then, we conducted a phase I study of @entity1 / @entity3 and @entity5 that is an oral fluoropyrimidine. The aim of this study was to determine the dose-limiting @entity2 (DLT), maximum-tolerated dose, and a recommended phase II dose of @entity5 . Response was assessed as a secondary endpoint. @entity0 AND METHODS: @entity0 who have been diagnosed with unresectable or postoperative recurrent @entity4 received @entity3 (25  mg/m(2) i.v. for 120  min) followed by @entity1 (1,000  mg/m(2) i.v. for 30  min) on days 1 and 8, and oral @entity5 on alternate days; this regimen was repeated at 21-day intervals. A standard '3  +  3' phase I dose-escalation design was adopted. This study was registered with University hospital Medical Information Network (UMIN) Center in Japan, number UMIN000008415. RESULTS: Twelve @entity0 were evaluable in this study. No @entity0 developed DLTs. Recommended dose of @entity5 was 80 (<1.25  m(2)), 100 (1.25   <=  1.5  m(2)), and 120  mg (1.5  m(2)>= ) per day. One @entity0 could achieve conversion to curative surgery. CONCLUSION: This phase I study was performed safely and demonstrated encouraging response.

title: Phase I trial of @entity5 every other day in combination with XXXX / @entity3 for inoperable @entity4 .

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity4 ) describes a regenerative phenomenon in adult @entity0 skin, wherein fully functional hair follicles regenerate de novo in the center of large excisional wounds. Originally described in @entity2 , @entity3 , @entity5 , and @entity0 in 1940-60, the @entity4 phenomenon was reinvestigated in @entity1 only recently. The process of de novo hair regeneration largely duplicates the morphological and signaling features of normal embryonic hair development. Similar to hair development, @entity4 critically depends on the activation of canonical WNT signaling. However, unlike hair development, WNT activation in @entity4 is dependent on @entity6 signaling generated by the immune system's gamma delta (y  ) T cells. The cellular bases of @entity4 remain to be fully characterized, however, the available evidence leaves open the possibility for a blastema-like mechanism, wherein epidermal and/or dermal wound cells undergo epigenetic reprogramming toward a more plastic, embryonic-like state. De novo hair follicles do not regenerate from preexisting hair-fated bulge stem cells. This suggests that hair neogenesis is not driven by preexisting lineage-restricted progenitors, as is the case for amputation-induced @entity1 digit tip regeneration, but rather may require a blastema-like mechanism. The @entity4 model is characterized by several intriguing features, which await further explanation. These include: (i) minimum wound size requirement for activating neogenesis, (ii) restriction of hair neogenesis to the wound's center, (iii) imperfect patterning outcomes, both in terms of neogenic hair positioning within the wound and in terms of their orientation. Future inquires into the @entity4 process, made possible by a wide array of the available skin-specific genetic tools, will undoubtedly expand our understanding of the regeneration mechanisms in adult mammals.

title: Principles and mechanisms of regeneration in the XXXX model for wound-induced hair follicle neogenesis.

answer: @entity1


abstract: UNASSIGNED: e14626 Background: Unresectable @entity4 is commonly treated with @entity3 -based chemotherapy. Consolidative radiotherapy (RT) is increasingly being used for @entity0 with @entity2 . @entity5 and @entity6 are important causes of morbidity and mortality in @entity4 . The impact of MMT vs. chemotherapy alone on survival and biliary obstruction has not yet been characterized. METHODS: Using the MD Anderson @entity1 registry, we identified 137 @entity0 with @entity4 from 1998-2009 and retrospectively reviewed their records for demographic, epidemiologic, and treatment data. We performed analyses of @entity9 ( @entity9 ) using the Kaplan-Meier method with stratification by extent of disease (locally advanced vs. metastatic). We used the Pearson chi-square test to analyze the impact of RT on measures of disease-related morbidity. RESULTS: The median @entity9 of the entire group was 48 weeks. 64% of @entity0 had locally advanced disease and 71% received at least one line of therapy. @entity0 receiving first-line @entity3 plus @entity7 (n=42) had a superior @entity9 when compared to those receiving other first-line therapies (n=55; 71 weeks vs. 50 weeks, p=0.02). There was no significant improvement in @entity9 in those @entity0 who received RT (n=48) vs. those who never received RT (n=49; 58 weeks vs. 54 weeks, p=0.96). However, @entity9 with consolidative RT (n=13) was 113 weeks vs. 70 weeks with chemotherapy alone (n=29) [p=0.11]. RT did not significantly reduce the morbidity of @entity4 , including non-elective biliary stent exchanges (p=0.79), admissions for obstructive @entity8 or @entity6 (p=0.57), and non-elective, cancer-related admissions (p=0.69). CONCLUSIONS: This series of @entity4 @entity0 confirms the previously reported survival improvement with @entity3 plus @entity7 in the first-line setting for bile duct @entity1 . The role of RT in reducing biliary complications from @entity4 remains unclear. Consolidative RT may increase survival in selected @entity0 compared to chemotherapy alone, although this requires further investigation in prospective, randomized clinical trials.

title: The role of multimodality therapy (MMT) in XXXX ( @entity4 ).

answer: @entity4


abstract: OBJECTIVE: To explore the expression of caveolin-1 ( @entity1 -1) induced by interleukin-17F/IL-17 receptor C ( @entity2 / @entity3 ) in @entity0 pulmonary microvascular endothelial cells (PMVECs). METHODS: Cultured PMVECs were divided into two groups of time-dependent experiment and @entity3 signal pathway intervention according to the results of time-dependent experimental group: namely peak time of @entity2 -induced @entity1 -1 and its phosphorylation (p- @entity1 -1) expression of PMVEC for formulating the incubation time between @entity2 and PMVEC in @entity3 signal pathway intervention group. Time-dependent experiment group: Western blot was used to detect the expression of @entity1 -1 after @entity2 stimulation for 0, 0.5, 1.5, 3.0, 6.0, 12.0, 24.0 h. @entity1 -1 and its phosphorylation expression after @entity2 challenge for 0, 10, 30, 60, 90, 120 min were evaluated by Western blot. @entity3 signal pathway intervention group: PMVECs were divided into two groups after a 3-day pre-treatment of siRNA. The first group received a 60-min stimulation of 100 ng/ml @entity2 before detecting the expression of p- @entity1 -1 while the second group was subject to a 24-hour stimulation of 100 ng/ml @entity2 before detection. In addition, control, meaningless-siRNA, @entity3 -siRNA, @entity2 and meaningless-siRNA + @entity2 groups were set as references for two groups respectively. RESULTS: @entity2 up-regulated the expression of @entity1 -1 in a time-dependent manner. At 0, 0.5, 1.5, 3.0, 6.0, 12.0, 24.0 h, the relative expression levels of @entity1 -1 were (1.139    0.134), (1.276    0.166), (1.604    0.080), (2.115    0.231), (2.763    0.226), (3.309    0.493) and (3.963    0.169). At 1.5 h, it was significantly higher than 0 h, peaked at 24.0 h and remained significantly higher than 0, 0.5, 1.5, 3.0, 6.0, 12.0 h (all P < 0.05). And @entity2 increased the expression of p- @entity1 -1 in a time-dependent manner. At 0, 10, 30, 60, 90, 120 min, the relative expression levels of p- @entity1 -1 were (0.540    0.085), (0.880    0.084), (1.437    0.297), (1.491    0.212), (1.017    0.210) and (0.882    0.074). At 10 min, p- @entity1 -1 was significantly higher than 0 min, peaked at 60 min, remained significantly higher than 0, 10, 30, 90, 120 min (all P < 0.05) and gradually decreased. At 120 min, it was still higher than 0 min. Compared with @entity2 group, @entity3 -siRNA significantly inhibited @entity2 -induced @entity1 -1 and its phosphorylation (2.126    0.318 vs 3.897    0.424 and 1.014    0.136 vs 1.431    0.298, all P < 0.05). CONCLUSIONS: @entity2 up-regulates the expressions of @entity1 -1 and p- @entity1 -1 in a time-dependent manner in PMVECs. And the silenced expression of @entity3 in PMVECs by @entity3 -siRNA significantly inhibits the @entity2 -induced expressions of @entity1 -1 and p- @entity1 -1.

title: [Effects of IL-17F/IL-17RC on the expression of caveolae-1 in XXXX pulmonary microvascular endothelial cells].

answer: @entity0


abstract: AIM: To explore whether it is possible to predict a @entity0 's eventual @entity1 phenotype using characteristics at initial presentation, we reassessed 111 young @entity0 on average 7.8    4.2 (2.2-19.7) [mean    SD (range)] years after diagnosis. METHODS: Medical records at diagnosis for 111 @entity0 , aged 0-17, were compared with their follow-up characteristics including stimulated @entity8 (CP) and islet @entity7 ( @entity7 ). RESULTS: Initially, 18 @entity0 were @entity2 ; 9 displayed other @entity6 (T2DM) features ( @entity10 , @entity9 , diagnosed T2DM); the remaining 84 had a classic type 1 @entity1 (T1DM) presentation. At follow-up, 83 @entity0 (75%) with no measured CP were classified as T1DM; 17 (15%) were CP+ and @entity7 - and thus considered T2DM. Eleven @entity0 with both T1DM and T2DM features were classified as having mixed @entity1 phenotype ( @entity4 ). One-fifth (22 subjects) changed presumed phenotype at follow-up. In multivariable models, T1DM @entity0 were younger at diagnosis, had higher initial @entity3 values, were more likely to have experienced @entity5 , and less likely to be @entity2 or of African American ethnicity. CONCLUSIONS/INTERPRETATION: Ten percent of subjects had @entity4 and 15% had T2DM at    8 years' duration. Although no onset feature was completely reliable, @entity5 and @entity11 were more likely to predict T1DM; @entity2 and African American ethnicity made T2DM more likely. At diagnosis, features of T2DM in addition to @entity2 were strongly predictive of eventual T2DM phenotype. Given the significant percentage who changed or had mixed phenotype, careful tracking of all young @entity0 with @entity1 is essential to correctly determine eventual disease type.

title: Onset features and subsequent clinical evolution of childhood XXXX over several years.

answer: @entity1


abstract: @entity5 during @entity4 ( @entity4 ) are rare but when they occur, have serious consequences. These have traditionally been managed with open exploration and repair, but more recently there has been a trend towards percutaneous endovascular management. We performed a systematic review of the literature to assess if this change in trend has led to an improvement in the overall reported rates of morbidity and mortality during the last 22 years in comparison with the reviews of the literature published previously. We found a total of 61 articles describing 138 @entity5 in 124 @entity0 . Injuries because of a laceration were the most prevalent (n = 51, 44%) and the most common presenting feature, when recorded, was @entity3 (n = 41, 53.3%). Delay in diagnosis was associated with the type of @entity2 (p < 0.001) and the clinical presentation (p  =  0.002). Open exploration and repair was the most common form of management, however percutaneous endovascular intervention was used in one third of the injuries and more constantly during the last 13 years. The main overall reported complications included @entity1 (n = 9, 7.3%), amputation (n = 2, 1.6%), and persistent ischaemia (n = 9, 7.3%). When compared with previous reviews there was a similar rate of mortality but lower rates of amputation and @entity6 , especially in @entity0 managed by endovascular strategies. Cite this article: Bone Joint J 2015;97-B:1447-55.

title: XXXX during arthroplasty of the hip.

answer: @entity5


abstract: BACKGROUND: @entity0 with @entity2 ( @entity2 ) beyond the Milan criteria are expected to have inferior outcome after liver transplantation (LT) and are therefore currently not considered for LT in many countries. The purpose of this study was to identify predictive factors for overall survival following LT for @entity2 that may support the Milan criteria in the selection of appropriate transplant candidates. METHODS: Clinicopathological data on 364 @entity0 with @entity2 who underwent LT between 1989 and 2010 were retrospectively evaluated. Predictors of overall survival in the entire cohort as well as in subsets of @entity0 within (n = 214) and beyond (n = 150) the Milan criteria were analyzed. RESULTS: Multivariate analysis in the entire cohort identified DNA index >1.5 (p < 0.0001), @entity3 ( @entity3 ) >200 ng/ml (p = 0.005), and @entity2 beyond the Milan criteria (p = 0.002) to be associated with worse overall survival. In @entity0 within the Milan criteria (median survival: 170 months), DNA index >1.5 (p < 0.0001) was the only predictor of worse overall survival in multivariate analysis. In @entity0 beyond the Milan criteria (median survival: 44 months), DNA index >1.5, @entity3 >200 ng/ml, microvascular invasion, @entity0 age >60 years, and DNA index >1.5 concomitant with @entity3 >200 ng/ml were associated with worse overall survival in univariate analysis. Multivariate analysis identified DNA index >1.5 concomitant with @entity3 >200 ng/ml (p < 0.0001) as the only independent predictor of worse overall survival. Consequently, @entity0 beyond the Milan criteria with a combined favorable DNA index  <=1.5 and @entity3  <=200 ng/ml had a median survival (147 months) comparable to that of @entity0 within the Milan criteria. CONCLUSIONS: DNA index and @entity3 level predict overall survival following LT in @entity0 with advanced @entity2 beyond the Milan criteria. A combined assessment of these markers during the evaluation of transplant candidates can contribute to the selection of @entity0 with @entity2 who may benefit from LT independently of their @entity1 burden.

title: XXXX DNA Index and @entity3 Define Outcome following Liver Transplantation for Advanced @entity2 .

answer: @entity1


abstract: OBJECTIVE: @entity2 ( @entity2 ) is associated with almost 300,000 @entity1 per year in the United States. Novel oral anticoagulants (NOACs) offer an alternative to @entity3 -based therapy without monitoring requirements and with fewer drug and food interactions. @entity4 , a direct Xa inhibitor, is approved by the Food and Drug Administration (FDA), based upon results of the Hokusai- @entity2 Phase 3 trial. The trial demonstrated that @entity4 administered once daily after initial treatment with heparin was non-inferior in reducing the risk of @entity2 recurrence and caused significantly less major and clinically relevant non-major (CRNM) bleeding compared to @entity3 . The objective of this study was to evaluate the cost-effectiveness of @entity4 versus @entity3 for the treatment of adults with @entity2 . METHODS: A cost-effectiveness model was developed using @entity0 -level data from the Hokusai- @entity2 trial, clinical event costs from real-world databases, and drug acquisition costs for @entity3 of  0.36 and @entity4 of  9.24 per tablet. RESULTS: From a U.S. health-care delivery system perspective, the incremental cost-effectiveness ratio (ICER) was  22,057 per quality adjusted life year (QALY) gained. Probabilistic sensitivity analysis showed that @entity4 had an ICER < 50,000 per QALY gained relative to @entity3 in 67% of model simulations. The result was robust to variation in key model parameters including the cost and disutility of @entity3 monitoring. CONCLUSION: Despite its higher drug acquisition cost, @entity4 is a cost-effective alternative to @entity3 for the treatment of @entity2 .

title: Cost-effectiveness of XXXX for the treatment of @entity2 based on the Hokusai- @entity2 study.

answer: @entity4


abstract: INTRODUCTION: @entity2 of the pleura (SFTP) are @entity1 arising from mesenchymal cells. Immunohistochemical studies have demonstrated that the origin of these @entity1 is mesenchymal rather than mesothelial. The aim of this study is to present our experience with diagnosing and treating @entity0 with SFTP. MATERIAL AND METHODS: We analyzed 18 @entity0 treated at the Department of Thoracic Surgery of the Medical University of Lodz. The @entity0 ' medical histories and the results of postoperative histopathological investigation of the @entity1 were analyzed. Postoperative histopathological samples were evaluated with regard to the current criteria of @entity1 . RESULTS: In 17 @entity0 , the @entity1 were surgically removed. Benign and small lesions (less than 3 cm in size) were removed by video-assisted thoracoscopic surgery (VATS). In 5 cases, @entity1 were found in the postoperative material. CONCLUSIONS: @entity2 of the pleura is a @entity1 with frequently asymptomatic clinical course. Treatment consists in resection which includes the adjacent structures, especially if the @entity1 is malignant.

title: XXXX of the pleura - analysis of 18 cases.

answer: @entity2


abstract: The mechanisms of progression from @entity5 to @entity5 and @entity1 are not well elucidated. Hepatocellular apoptosis could be one of the key factors in the pathogenesis of @entity8 ( @entity8 ). @entity2 ( @entity2 ) protects liver cells from various toxins. We previously reported that @entity2 is critically important for the survival of hepatocytes due to its mitochondrial association. This study aims to investigate the relationship between @entity2 and hepatocellular apoptosis in vivo models of high-fat diet-induced @entity8 and in vitro models of @entity7 -induced @entity3 . @entity0 were fed a high-fat diet for 8, 12 and 16  weeks. Hepatic histological lesions, liver function and apoptosis were examined. @entity2 expression, in association with @entity6 and cytochrome c leakage, which are both indicators of cell apoptosis, was measured. Results showed that a high-fat diet altered liver function and histology in a manner resembling @entity8 . Hepatic protein and mRNA @entity2 expression was decreased as @entity8 progressed. Meanwhile, cell apoptosis increased as result of @entity6 activation and cytochrome c release, indicating that @entity2 might be involved in @entity8 pathogenesis. Furthermore, in @entity7 -induced @entity2 , over-expression of @entity2 decreased cells apoptosis. In contrast, repression of @entity2 expression by siRNA increased cell apoptosis. In conclusion, these data imply that cell apoptosis contributes to the pathogenesis of @entity8 , during which @entity2 expression is downregulated. Increasing @entity2 expression in hepatocytes may forestall cell apoptosis as result of @entity4 insult.

title: Increased hepatic apoptosis in high-fat diet-induced @entity8 in XXXX may be associated with downregulation of hepatic stimulator substance.

answer: @entity0


abstract: BACKGROUND: Most @entity1 vaccines are manufactured in eggs, and the inactivated virus is purified for injection. For a seasonal @entity1 product, manufacturing, distribution, and perhaps even vaccine coverage, would be greatly improved with an oral tablet alternative made in cell culture. We aimed to assess the safety and immunogenicity of an oral tablet vaccine against @entity1 A H1N1 in healthy adults. METHODS: At a single site, we did a randomised, double-blind, placebo-controlled trial of a monovalent @entity1 A H1N1 vaccine to establish the safety and immunogenicity of a recombinant, non-replicating, adenovirus vector expressing haemagglutinin and double-stranded RNA adjuvant delivered orally by tablets. @entity0 had to have an initial haemagglutination inhibition titre of at @entity2 , be aged between 18 and 49 years, and be in good health. We randomly assigned (1:1) @entity0 to receive either a single oral dose of vaccine or placebo. Randomisation was done by computer-generated assignment, and study drug was distributed with concealed identity to the masked staff by an unmasked pharmacist. Investigative site staff, @entity0 directly involved with immunological assays or the assessment of clinical safety, and @entity0 were masked to treatment assignments. Solicited symptoms of reactogenicity were assessed, and all safety assessments were reported through the active phase of the study (day 28). Immunogenicity was assessed by haemagglutination inhibition titres, the percentage of @entity0 that seroconverted, microneutralisation titres, and the number of antibody secreting cells. Descriptive statistics were used for continuous variables and t-tests or Fisher's exact tests were used to compare treatment groups. The study is registered at ClinicalTrials.gov, number NCT01688297. FINDINGS: 24 @entity0 were enrolled in the study at WCCT Global between Dec 2, 2013, and April 15, 2014. Adverse events were mild in nature, and occurred with similar frequency in vaccine (four events) and placebo recipients (four events). After immunisation, 11 (92%) of 12 vaccine-treated @entity0 had a four-fold increase in haemagglutination inhibition titres (group geometric mean fold rise of 7  7) and microneutralisation titres (group geometric mean fold rise of 29). No @entity0 in the placebo group had a four-fold increase in haemagglutination inhibition titres (group geometric mean fold rise of 1  1) or microneutralisation titres (group geometric mean fold rise of 1  0). Neutralising antibody responses to @entity1 were not hindered by pre-existing immunity to the vector. INTERPRETATION: An oral recombinant adenovirus vaccine to @entity1 was well tolerated and can elicit neutralising antibody responses to @entity1 virus in @entity0 beings. These data are a step forward in making oral @entity1 vaccination possible. FUNDING: Vaxart Inc.

title: High titre neutralising antibodies to XXXX after oral tablet immunisation: a phase 1, randomised, placebo-controlled trial.

answer: @entity1


abstract: @entity9 is a triggering agent for reactive @entity4 in HLA-B27-susceptible individuals. Considering the intracellular multiplication of bacteria, it seems likely that bacterial peptides may be presented by the major histocompatibility complex (MHC) class I pathway. To examine this hypothesis, we infected @entity6 *2705- and/or @entity0 @entity7 -transfected @entity1 L-cell lines with @entity10 , an invasive strain of @entity9 . @entity8 induced no detectable modifications in the biosynthesis and expression level of HLA-B27, as assessed by immunoprecipitation, Northern blot analysis, and flow cytometry. Using confocal microscopy, we observed that @entity8 induced a clustering of HLA-B27 molecules during macropinocytosis and before bacterial dissemination from cell to cell. Peptides naturally bound to HLA-B27 molecules were acid eluted from infected cells and separated by high-performance liquid chromatography. Major differences were observed in high-performance liquid chromatography profiles and in the nature of peptides presented following @entity8 . Although most of the antigens presented were not accessed by Edman degradation, we obtained two sequences partially homologous to bacterial proteins. These peptides lacked the major HLA-B27 peptide anchor ( @entity3 ) at position 2, and one had an unusual length of 14 @entity5 . These data suggest that alterations in the peptide presentation by HLA-B27 occur during @entity2 , which could be relevant to the pathogenesis of HLA-B27-related @entity4 .

title: Alteration of HLA-B27 peptide presentation after XXXX of transfected @entity1 L cells by @entity9 .

answer: @entity2


abstract: The role of the cerebellum in the spatial tuning of goal-directed multi-joint movements in @entity0 is unknown. We analyzed the directional tuning of phasic EMG activities associated with upper limb reaching movements (12 targets) in the vertical plane in healthy subjects and in @entity0 exhibiting @entity2 . Tuning of phasic EMG activities was investigated in seven muscles (brachioradialis, biceps, medial and long head of triceps, anterior and posterior deltoid, latissimus dorsi). We digitally compressed the EMG activities corresponding to slow reaches to the same targets into the time frame of the fast EMG traces. Estimates of gravity-related components were subtracted. Peaks of EMG activities in the resulting phasic traces were identified for each muscle and each target. Aberrant privileged directions of M Peak EMG (directions associated with the maximal peak of EMG amongst the 12 peaks of EMG activity in the sagittal plane) were found in all @entity1 @entity0 . Directional dominance, defined as the ratio of the M Peak EMG divided by the peak EMG in the opposite direction, was significantly higher in controls than in @entity1 @entity0 for one distal muscle (brachioradialis) and one proximal muscle (anterior deltoid). The spreading of EMG activities assessed by the global areas of the polar plots of phasic traces was broader in @entity0 for the biceps and medial head of triceps. The distribution of densities of EMG activities (DDEMG) amongst the four quarters of the vertical plane, an index of the contrast in the intensities between quarters in polar plots, revealed increased values in control subjects for the brachioradialis, the biceps and the anterior deltoid as compared to @entity1 @entity0 . Representation of Net Vectors obtained from polar plots of peaks of EMG activities demonstrated an abnormal directional tuning in @entity1 @entity0 . In the majority of the cases, the Net Vector was outside the normal range for the following muscles: brachioradialis, biceps, anterior deltoid, posterior deltoid. This study reveals that @entity2 is associated with defective spatial properties of EMG activity during multiple joint movements. Privileged directions associated with M Peak EMG and Net Vectors are erroneous. We demonstrate that the cerebellum plays a determinant and unsuspected role in the spatial modulation of activation during speed-related action for reaching.

title: Directional tuning of speed-related activation for reaching in the vertical plane in XXXX .

answer: @entity2


abstract: @entity8 is a common @entity7 world-wide but not in Central Europe. The typical clinical manifestation is an enlarging papule on the site of @entity2 . Vectors are sandflies and reservoirs may be wild animals like rodents, @entity1 or even @entity0 . @entity0 with any kind of @entity3 are at risk. We report on two otherwise healthy @entity0 , 16 and 18 years-of-age, who presented non-healing @entity4 . The diagnosis of @entity8 was confirmed through intracellular amastigotes in Giemsa stains of skin biopsies. One @entity2 was of Syrian origin and the other was contracted in Tuscany. Since both lesions were classified as complex cutaneous lesions, drug therapy was initiated with @entity6 orally or intralesional @entity5 antimonite. A complete response was obtained in both @entity0 . No other adverse effects rather than injection pain with @entity5 antimonite were observed. We should be aware of @entity8 in travelers returning from endemic regions or from migrants and refugees from endemic regions.

title: Non-healing XXXX : cutaneous old world leishmaniasis in dresden.

answer: @entity4


abstract: BACKGROUND: Meat protein digestibility can be impaired because of indigestible protein aggregates that form during cooking. When the aggregates are subsequently fermented by the microbiota, they can generate potentially harmful compounds for the @entity2 . OBJECTIVE: This study evaluated the quantity of @entity1 meat protein escaping digestion in the @entity0 small intestine and the metabolic fate of exogenous @entity4 , depending on cooking processes. METHODS: Sixteen volunteers (5 @entity0 and 11 @entity0 ; aged 28    8 y) were equipped with a double lumen intestinal tube positioned at the ileal level. They received a test meal exclusively composed of 120 g of intrinsically @entity6 -labeled @entity1 meat, cooked either at 55  C for 5 min (n = 8) or at 90  C for 30 min (n = 8). Ileal effluents and blood and urine samples were collected over an 8-h period after the meal ingestion, and @entity6 enrichments were measured to assess the digestibility of meat proteins and the transfer of dietary @entity4 into the metabolic pools. RESULTS: Proteins tended to be less digestible for the meat cooked at 90  C for 30 min than at 55  C for 5 min (90.1%    2.1% vs. 94.1%    0.7% of ingested N; P = 0.08). However, the particle number and size in ileal digesta did not differ between groups. The appearance of variable amounts of intact fibers was observed by microscopy. The kinetics of @entity6 appearance in plasma proteins, @entity5 , and @entity3 were similar between groups. The amount of exogenous @entity4 lost through deamination did not differ between groups (21.2%    0.8% of ingested N). CONCLUSIONS: Cooking @entity1 meat at a high temperature for a long time can moderately decrease protein digestibility compared with cooking at a lower temperature for a short time and does not affect postprandial exogenous protein metabolism in young adults. The study was registered at www.clinicaltrials.gov as NCT01685307.

title: High True Ileal Digestibility but Not Postprandial Utilization of XXXX from @entity1 Meat Protein in @entity0 Is Moderately Decreased by High-Temperature, Long-Duration Cooking.

answer: @entity4


abstract: OBJECTIVE: To investigate the cutaneous safety and tolerability of @entity3 1.2%/ @entity4 3.75% gel in moderate-to-severe @entity2 @entity0 . METHODS: A safety assessment of 498 @entity0 with moderate-to-severe @entity2 receiving @entity3 1.2%/ @entity4 3.75% gel or vehicle for 12 weeks. RESULTS: The vast majority (80-95%) of @entity0 reported no cutaneous safety or tolerability problems throughout the study. Mean scores for both active and vehicle were all <1 (where l=mild) and reduced over the duration of the study. When scaling, @entity1 , itching, burning, or stinging was reported it was generally mild. Moderate or severe reactions to @entity3 1.2%/ @entity4 3.75% gel were rare and generally seen early in treatment. There were eight reports (3.3%) of moderate @entity1 , four reports (1.7%) of moderate scaling, three reports (1.2%) of moderate itching, and one report of moderate burning (0.4%) at Week 4. There was one report (0.4%) of severe @entity1 and one report (0.4%) of severe burning (both at Week 4), with one report (0.4%) of severe stinging at Week 12. There were no substantive differences seen in cutaneous tolerability among treatment groups and younger @entity0 tended to have milder reactions. LIMITATIONS: It is not possible to determine the contributions of the individual active ingredients. CONCLUSION: @entity3 1.2%/ @entity4 3.75% gel has a favorable safety and tolerability profile with very low incidence of moderate or severe reactions.

title: Cutaneous Safety and Tolerability of a Fixed Combination Clindamycin (1.2%) and @entity4 (3.75%) Aqueous Gel in Moderate-to-severe XXXX .

answer: @entity2


abstract: We evaluated the efficacy and safety of three concentrations of @entity4 infused epidurally as @entity3 for @entity0 undergoing orthopedic procedures. @entity0 undergoing elective hip or knee joint replacement were enrolled in the study (n = 105). Sensory blockade was established preoperatively with 10-15 mL of 0.75% @entity4 . @entity0 were then randomized to receive 0.0625%, 0.125%, or 0.25% @entity4 as a continuous epidural infusion at 6 mL/h for 24 h. IV @entity2 @entity0 -controlled @entity3 was given as rescue @entity3 , and time to first request for @entity3 and total dose of @entity2 consumed were recorded. Sensory blockade, motor blockade, visual analog scale @entity1 score, and cardiovascular variables were also recorded at regular intervals postoperatively. Ninety-one @entity0 were included in the primary intent-to-treat analysis. Total normalized dose of @entity2 , number of @entity0 -controlled @entity3 requests, and overall postoperative visual analog scale @entity1 scores were significantly lower for the 0.25% group compared with the other two groups, and the time to first request for rescue @entity3 was longer. There was no significant difference between the 0.125% and 0.25% groups in terms of maximum motor blockade achieved and time to minimal motor blockade. Safety data were equivalent among the three groups. We conclude that @entity4 as a continuous epidural infusion provided adequate postoperative @entity3 and that the 0.25% concentration provided significantly longer @entity3 than 0.125% or 0.0625% @entity4 without any significant increase in detectable motor blockade relative to the 0.125% group. IMPLICATIONS: Postoperative epidural infusion of @entity4 can provide safe and effective @entity3 for @entity0 having hip or knee joint replacement. Of the three concentrations we infused at a constant rate, 0.25% provided significantly better @entity1 relief.

title: The efficacy and safety of three concentrations of XXXX administered as a continuous epidural infusion in @entity0 undergoing orthopedic surgery.

answer: @entity4


abstract: Delivery of neurotrophic molecules to the brain has potential for preventing @entity4 in @entity3 . @entity6 ( @entity6 ) epithelial cells secrete numerous neurotrophic factors, and encapsulated @entity6 transplants are neuroprotective in models of @entity1 and @entity5 ( @entity5 ). To date, all studies examining the neuroprotective potential of @entity6 transplants have used cells isolated from young donor animals. Because the aging process significantly impacts the cytoarchitecture and function of the @entity6 the following studies determined whether age-related impairments occur in its neuroprotective capacity. @entity6 was isolated from either young (3-4 months) or aged (24 months) @entity0 . In vitro, young @entity6 epithelial cells secreted more @entity7 and were metabolically more active than aged @entity6 epithelial cells. Additionally, conditioned medium from cultured aged @entity6 was less potent than young @entity6 at enhancing the survival of serum-deprived neurons. Finally, encapsulated @entity6 was tested in an animal model of @entity5 . Cell-loaded or empty alginate capsules (control group) were transplanted unilaterally into the @entity0 striatum. Seven days later, the animals received an injection of @entity8 (QA; 225 nmol) adjacent to the implant site. Animals were tested for motor function 28 days later. In the control group, @entity2 severely impaired function of the contralateral forelimb. Implants of young @entity6 were potently neuroprotective as @entity0 receiving @entity6 transplants were not significantly impaired when tested for motor function. In contrast, implants of @entity6 from aged @entity0 were only modestly effective and were much less potent than young @entity6 transplants. These data are the first to directly link aging with diminished neuroprotective capacity of @entity6 epithelial cells.

title: Aging reduces the neuroprotective capacity, XXXX secretion, and metabolic activity of @entity0 choroid plexus epithelial cells.

answer: @entity7


abstract: STUDY OBJECTIVES: To evaluate the histocompatibility of four different materials used to cover expandable metallic stents. DESIGN: Prospective, randomized, unblinded study. SETTING: Animal research laboratory of Kurume University. @entity0 OR @entity0 : Twenty 12- to 18-kg mongrel @entity1 . INTERVENTIONS: Handmade Gianturco-type stents with six bends, 20 mm in length, and 15 to 20 mm in diameter were covered using four different materials: @entity5 mesh, @entity3 -coated mesh, @entity4 mesh, and ePTFE. Covered stents were inserted into the @entity2 after i.v. anesthesia. Five animals were used in each group. MEASUREMENTS AND RESULTS: Postinsertion status was observed using clinical and bronchoscopy measures 7, 14, 28, and 56 days after intervention. Eight weeks after stent insertion, the tracheal specimens were studied pathologically. A scoring system was used to evaluate the histocompatibility of covered stents in each study group. The mean of clinical scores in the @entity5 group was 1.84+/-0.36, which was significantly higher than those in the groups of @entity3 , @entity4 , and ePTFE. The means of histopathologic scores in the @entity5 group and the @entity3 group were 1.60+/-0.55, which were significantly higher than those in groups of @entity4 and ePTFE. CONCLUSIONS: @entity5 mesh cover was more suitable than @entity3 -coated mesh, @entity4 mesh, and ePTFE because of its excellent histocompatibility.

title: Experimental study of the histocompatibility of covered expandable metallic stents in the XXXX .

answer: @entity2


abstract: OBJECTIVE AND IMPORTANCE: Chronic encapsulated @entity10 is a fairly rare clinical entity. This unique lesion is peculiar for its clinical onset, formation of a capsule, and progressive enlargement. The mechanism for capsule formation and self-perpetuating expansion still remains uncertain, as well as the causal relationship with @entity9 . Because of their pseudotumoral course and misleading neuroradiological features, these lesions can be misdiagnosed preoperatively as @entity7 . CLINICAL PRESENTATIONS: A 62-year-old @entity0 was referred with a 2-month history of generalized @entity3 . There was no history of @entity4 or arterial @entity2 . The results of a neurological examination were normal. Computed tomographic scans revealed a slightly hyperdense roundish area in the right parietotemporal region with ring-like enhancement after contrast medium injection, moderate mass effect, and perifocal low attenuation. With the provisional diagnosis of @entity6 , the @entity0 was admitted for a craniotomy. Before surgery, a thallium-201 single photon emission computed tomographic study was performed, which showed no abnormal uptake of the tracer, raising significant doubt regarding the presumptive diagnosis of a @entity1 . INTERVENTION: Intraoperative findings revealed a @entity8 , with a well-demarcated, thick, fibrous-elastic capsule. There was evidence of repeated intracapsular @entity5 . The lesion was totally removed, and the @entity0 recovered fully. No other pathological findings, including @entity9 , were noted. CONCLUSION: Chronic encapsulated intracerebral @entity8 probably occur more frequently than the limited number of reported cases would indicate. This case represents a realistic clinical problem-solving setting in with @entity11 -201 single photon emission computed tomography was used because of its capacity for functional @entity1 detection and differential diagnosis.

title: Chronic encapsulated XXXX : contribution of thallium-201 single photon emission computed tomography in preoperative diagnosis: case report.

answer: @entity10


abstract: To evaluate the antihypertensive effects of @entity5 , a renally excreted angiotensin-converting enzyme inhibitor, we assessed supervised administration of the drug after hemodialysis (HD) three times weekly. Blood pressure (BP) was assessed by interdialytic 44-hour ambulatory BP (ABP) monitoring, and endocrine responses were assessed by plasma @entity3 activity (PRA) before and after dialysis. @entity5 dose was titrated at biweekly intervals. If this was not effective after full titration ( @entity5 to 40 mg three times weekly), ultrafiltration was added to reduce dry weight. The primary outcome variable was change in BP from the end of the run-in period to the end of the study. No change in mean ABP was noted during run-in. However, mean 44-hour ABP decreased from 149 +/- 14 (SD)/84 +/- 9 to 127 +/- 16/73 +/- 9 mm Hg, a decrease of 22/11 mm Hg (P < 0.001) at final evaluation. Of 11 @entity0 who completed the trial, only 2 @entity0 had systolic @entity1 (>/=135 mm Hg) and 1 @entity0 had diastolic @entity1 (>/=85 mm Hg) at the final visit. Four @entity0 were administered 10 mg of @entity5 ; 5 @entity0 , 20 mg; and 2 @entity0 , 40 mg; only 1 of these @entity0 required ultrafiltration therapy. There was a persistent antihypertensive effect over 44 hours. BP reduction was achieved without an increase in intradialytic symptomatic or asymptomatic @entity2 episodes. PRA increased in response to dialysis, as well as @entity5 . In conclusion, supervised @entity5 therapy is effective in controlling @entity1 in chronic HD @entity0 . This may be related to blockade of @entity4 generation by kidneys despite the loss of excretory function.

title: XXXX therapy for hemodialysis @entity1 : hemodynamic and endocrine responses.

answer: @entity5


abstract: Infections are a major cause of morbidity and mortality in chronic hemodialysis @entity0 . This single center prospective study was carried out to determine the incidence and risk factors for @entity1 in hemodialysis @entity0 and plan appropriate strategies to reduce the risk of @entity1 . A total of 84 consecutive @entity0 who were initiated on hemodialysis over a 2-year period were followed until they either received a kidney transplant or died. In our hospital, as a policy, @entity0 are offered hemodialysis as a bridge therapy to a kidney transplant. The mean duration of follow up was 3 months (range 1-11.8 months). The factors associated with at least one episode of @entity1 were evaluated. Statistical analysis was done by multivariate stepwise logistic regression method. Fifty-one @entity0 had a total of 57 episodes (67.8%) of @entity1 . Of the 44 episodes of acute @entity6 , vascular access exit site @entity1 was the commonest followed by @entity3 (13 @entity0 , 29.5%). @entity5 was the commonest bacterial isolate observed in 14 @entity0 . On multivariate analysis, three risk factors for @entity1 were identified: (1) nonarteriovenous fistula (AVF) vascular access for hemodialysis (p = 0.02), (2) increased number of hemodialysis sessions (p = 0.03), and (3) lower serum @entity4 level (p = 0.02). NonAVF vascular access was found to be the most important risk factor for @entity1 in hemodialysis @entity0 . Creation of an @entity2 , preferably at an early stage, appears beneficial for minimizing the risk of @entity1 even in @entity0 who are on short-term hemodialysis as a bridge therapy towards a kidney transplant.

title: Role of vascular access as a risk factor for XXXX in hemodialysis.

answer: @entity1


abstract: BACKGROUND: To confirm the hypothesis that reducing the interval between surgery and adjuvant chemotherapy could improve prognosis, a randomized multicentric study of adjuvant perioperative chemotherapy (POC) in @entity0 was initiated. METHODS: A total of 552 @entity1 were randomized to evaluate whether the addition of POC to standard adjuvant treatment significantly improved outcome. @entity1 were stratified according to menopausal status, with 362 @entity1 in the postmenopausal group and 192 @entity1 in the premenopausal group. Premenopausal @entity1 with positive axillary nodes, negative hormonal receptors, or grade 3 @entity3 received adjuvant @entity5 -based chemotherapy. Node-negative premenopausal @entity1 with grade 1 or 2 @entity3 expressing hormonal receptors received no standard adjuvant treatment. All postmenopausal @entity1 received hormonal therapy ( @entity4 20 mg/day for 3 years). The perioperative regimen was a 14 mg/m(2) @entity5 infusion at the end of @entity3 excision. RESULTS: With a median follow-up of 6.1 years, this study showed no significant advantage of POC on overall survival, disease-free survival, or @entity2 -free survival for the total cohort or for the premenopausal and postmenopausal groups. CONCLUSIONS: POC was a safe procedure in this study. However, the addition of POC to standard adjuvant treatment offered no benefit in @entity0 adjuvant treatment.

title: Randomized multicentric study of perioperative chemotherapy with XXXX in early @entity0 .

answer: @entity5


abstract: OBJECTIVES: @entity0 from Minority Ethnic groups tend to present late to @entity1 services, often in crisis. Culture-specific barriers to help-seeking seem to underlie this. We sought to determine these barriers to timely help-seeking for @entity1 among @entity0 from South Asian backgrounds and what the features of an intervention to overcome them would be. STUDY DESIGN: Qualitative study to delineate barriers to and facilitators of help-seeking for South Asian adults with @entity1 through focus groups and individual interviews. SETTING: Community settings in and around Greater London. @entity0 : To achieve a maximum variation sample, we purposively recruited 53 English or Bengali speaking South Asian adults without a known diagnosis of @entity1 through community centres and snowballing. RESULTS: @entity0 ranged in age from 18 to 83   years, were mostly female and were 60% Bangladeshi. We recruited @entity0 from different religions and occupational backgrounds and included those with experience of caring for someone with @entity1 as well as those without this experience. @entity0 identified four main barriers to timely diagnosis: barriers to help-seeking for @entity2 ; the threshold for seeking help for @entity2 ; ways to overcome barriers to help-seeking; what features an educational resource should have. CONCLUSIONS: We have identified the features of an intervention with the potential to improve timely @entity1 diagnosis in South Asians. The next steps are to devise and test such an intervention.

title: What would encourage help-seeking for XXXX among UK-based South Asians? A qualitative study.

answer: @entity2


abstract: BACKGROUND: Intraoperative cell salvage (ICS), hereby referred to 'mechanical red cell salvage', has been widely used and proven to be an effective way to reduce or avoid the need for allogeneic red blood cells (RBCs)transfusion and its associated complications in surgeries involving major @entity2 . However, little is known about the influence of this technique on the functional state of salvaged RBCs. Furthermore, there are no articles that describe the change of free hemoglobin (fHb) in salvage blood during storage, which is a key index of the quality control of salvaged blood. Therefore, in this study, the influence of ICS on the function of salvaged RBCs and the changes of salvaged RBCs during storage were studied with respect to the presence of @entity5 affinity (recorded as a P50 value) and the level of @entity4 ( @entity4 ) and fHb by comparing salvaged RBCs with self-venous RBCs and 2-week-old packed RBCs. METHODS: Fifteen @entity0 undergoing off-pump coronary artery bypass grafting (OPCAB) surgery were enrolled. Blood was collected and processed using a Dideco Electa device. The level of P50, 2, 3-DPG and fHB from salvaged RBCs, venous RBCs and 2-week-old packed RBCs was measured. We also measured the changes of these indicators among salvaged RBCs at 4  h (storage at 21-24   C) and at 24  h (storage at 1-6    C). RESULTS: The P50 value of salvaged RBCs at 0  h (28.77        0.27  mmHg) was significantly higher than the value of venous RBCs (27.07        0.23  mmHg, p   =   0.000) and the value of the 2-week-old packed RBCs (16.26        0.62  mmHg, p   =   0.000). P50 value did not change obviously at 4  h (p   =   0.121) and 24  h (p   =   0.384) compared with the value at 0  h. The 2, 3-DPG value of salvaged RBCs at 0  h (17.94        6.91   mol/g Hb) was significantly higher than the value of venous RBCs (12.73        6.52  mmHg, p   =   0.007) and the value of the 2-week-old packed RBCs (2.62        3.13  mmHg, p   =   0.000). The level of 2, 3-DPG slightly decreased at 4  h (p   =   0.380) and 24  h (p   =   0.425) compared with the value at 0  h. Percentage of @entity3 of the salvaged blood at 0  h(0.51        0.27  %) was significantly higher than the level of venous blood (0.07        0.05  %, p   =   0.000) and the value of 2-week-old packed RBCs (0.07        0.05  %, p   =   0.000), and reached 1.11        0.42  % at 4  h (p   =   0.002) and 1.83        0.77  % at 24  h (p   =   0.000). CONCLUSIONS: The @entity1 transport function of salvaged RBCs at 0  h was not influenced by the cell salvage process and was better than that of the venous RBCs and 2-week-old packed RBCs. At the end of storage, the @entity1 transport function of salvaged RBCs did not change obviously, but percentage of @entity3 significantly increased.

title: @entity1 carrying capacity of salvaged blood in XXXX undergoing off-pump coronary artery bypass grafting surgery: a prospective observational study.

answer: @entity0


abstract: UNASSIGNED: OBJECT The present study was conducted to investigate whether microbleeds or microinfarcts are associated with @entity4 ( @entity4 ) gene polymorphisms in @entity0 with @entity5 ( @entity5 ), and if so, whetherAPOE gene polymorphisms are also associated with @entity1 type in @entity0 with @entity5 . METHODS This cross-sectional, multicenter study included 86 consecutive @entity0 with @entity5 who underwent T2*-weighted gradient echo or susceptibility-weighted MR imaging and 83 healthy control volunteers. Baseline clinical and radiological characteristics were recorded at diagnosis, and inter- and intragroup differences in the @entity4 genotypes were assessed. Multivariate binary logistic regression models were used to determine the association factors for @entity6 ( @entity6 ) and hemorrhagic presentation in @entity0 with @entity5 . RESULTS There was no difference in @entity4 gene polymorphism and the incidence of @entity6 between @entity0 with @entity5 and healthy controls (p > 0.05). In the @entity5 group, 7 (8.1%) @entity0 had microbleeds and 32 (37.2%) @entity0 had microinfarcts. Microbleeds were more frequently identified in @entity0 with hemorrhagic-type than in nonhemorrhagictype @entity5 (p = 0.003). @entity4 genotypes differed according to the presence of microbleeds (p = 0.024). @entity4 or   4 carriers also experienced microbleeds more frequently than @entity4 /  3 carriers (p = 0.013). In the multivariate regression analysis in @entity0 with @entity5 , microbleeds were significantly related to @entity4 or   4 carrier status (OR 7.86; 95% CI1.20-51.62; p = 0.032) and @entity3 (OR 17.31; 95% CI 2.09-143.57; p = 0.008). Microinfarcts were independently associated with @entity2 (OR 3.01; 95% CI 1.05-7.86; p = 0.007). Hemorrhagic presentation was markedly associated with microbleeds (OR 10.63; 95% CI 1.11-102.0; p = 0.041). CONCLUSIONS These preliminary results did not show a difference in @entity4 gene polymorphisms between @entity0 with @entity5 and healthy @entity0 . However, they imply that @entity4 gene polymorphisms may play certain roles in the presence of microbleeds but not microinfarcts in @entity0 with @entity5 . A further confirmatory study is necessary to elucidate the effect of @entity4 gene polymorphisms and @entity6 on the future incidence of @entity1 in @entity0 with @entity5 .

title: Association of XXXX gene polymorphism with @entity6 and @entity1 type in @entity5 : a preliminary study.

answer: @entity4


abstract: This study aimed to explore the molecular mechanism in @entity2 invasion and @entity1 . The expression of @entity10 ( @entity6 , @entity7 ), tissue inhibitor-1 of matrix metalloproteinase ( @entity9 ), cell adhesion molecule 44 variant 6 (CD44v6), @entity8 and @entity4 was investigated in 154 @entity0 with @entity3 (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The expression of @entity6 , @entity7 , @entity9 , CD44v6, @entity8 /neu and @entity4 was found in @entity2 cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases respectively. Linear regression and correlation analysis revealed that there was close positive relationship (P<0.05) between the expression of @entity6 and @entity7 , @entity9 and CD44v6, @entity8 and @entity7 , @entity6 and @entity4 . Up-regulation of @entity6 was accompanied by @entity5 stage (P<0.01). There was also a trend of @entity6 expression being related with @entity2 @entity1 . Increased expression of @entity8 was found in @entity0 with @entity2 recurrence(P<0.05). The expression of @entity9 was higher in @entity2 than that in @entity2 , and higher in keratinizing and non-keratinizing SCC than that in basaloid SCC(P<0.05). These findings suggested that @entity6 and @entity7 , @entity8 and @entity7 , @entity6 and @entity4 had a coordinate function in aggression of @entity2 ; that @entity6 had a more important function than @entity7 in @entity2 invasion and @entity1 ; and that @entity8 might serve as a biomarker for poor prognosis in @entity3 .

title: Correlation of XXXX and CD44 variant 6 in head and neck @entity2 @entity1 .

answer: @entity10