abstract: OBJECTIVE: @entity2 and the management of @entity1 has posed considerable challenges to the treating physician. The aims of the study were to determine the incidence and factors influencing @entity1 and to identify at-risk @entity0 with cervical node-negative disease at presentation. STUDY DESIGN: Multicenter case series with retrospective chart review. SETTING AND SUBJECTS: In sum, 113 @entity0 with a histopathologic diagnosis of @entity2 across 6 tertiary hospitals in Australia and the United States. METHODS: Treatment modalities for the primary site and neck included surgery, radiotherapy, and combined therapy. Treatment outcomes were measured in relation to date of primary treatment, and long-term follow-up was recorded. Disease-free survival was calculated as time for @entity0 to develop @entity1 following primary treatment. RESULTS: A total of 113 @entity0 (46 females, 49.7    13.2 years) were identified with a median follow-up of 41.5 months (interquartile range, 58.2); 7.1% of @entity0 presented with @entity1 , while 8.8% of @entity0 presented with @entity1 . @entity1 was present in @entity0 with Hyams grade II (22.2%), III (55.6%), and IV (22.2%) lesions (  (2) = 5.66, P = .13). Histologic grade was higher in @entity0 with @entity1 (  (2) = 16.22, P = .001). Positive surgical margins were associated with a higher risk of @entity1 as compared with clear surgical margin (17.9% vs 5%, P = .034). CONCLUSION: Neck metastasis is an important clinical consideration for @entity2 at presentation and in surveillance. Primary treatment of the neck could be considered in select @entity0 . Long-term surveillance of the neck and primary site is essential.

title: XXXX : Fate of the Neck-A Long-term Multicenter Retrospective Study.

answer: @entity2


abstract: The antitumor effects of Corynebacterium parvum in a @entity1 @entity2 model depend upon a sequential activation of neutrophils and macrophages within the peritoneal cavity. We studied the sequential administration of biological response modifiers that independently activate each phase of the response. Tumor-challenged @entity1 treated by i.p. injection of a @entity3 -extracted fraction of cell-free @entity4 (PA-PE, 1400 micrograms) demonstrated prolonged survival in less than 20% of the cases. An i.p. injection of a detoxified Salmonella endotoxin (DSE) preparation (150 micrograms) had no effect on @entity0 outgrowth. However, i.p. treatment with PA-PE (1400 micrograms), followed by 150 micrograms of DSE 1 day later, resulted in long-term survival (greater than 100 days) in 40 to 60% of mice. This antitumor effect was only evident when PA-PE was administered first (before DSE) and optimal when DSE was administered 24 h after PA-PE. The synergistic antitumor effect could be duplicated when @entity0 -challenged @entity1 were first treated i.p. with peritoneal polymorphonuclear leukocytes, elicited by injection of PA-PE, and then treated with DSE 18 h later. These data indicate that appropriately timed injection of biological response modifiers with complementary effects can result in a synergistic prevention of @entity0 growth.

title: Synergistic effects of combination sequential immunotherapies in a XXXX @entity2 model.

answer: @entity1


abstract: The purpose of this study is to evaluate the effects of @entity8 on circulation, respiration, sedation, and liver function of the neonates. The study subjects are 27 neonates (body weight 2.1 to 3.8 kg, gestational age at birth 34 to 41 weeks) who underwent surgery in neonatal period. Of 27, 13 @entity0 received @entity9 (1.5 mg.kg-1) immediately before tracheal intubation (group L), and 14 had @entity8 (0.1 mg.kg-1) with @entity9 (group ML). We compared the effects of @entity8 in the presence of @entity9 on the following parameters: (1) the incidence of @entity3 (systolic blood pressure < 50 mmHg) and @entity7 (heart rate < 100 beats. @entity6 ), (2) the incidence of @entity2 and desaturation of @entity1 (< 80%), (3) the degree of sedation, and (4) the serum levels of @entity4 and unbound @entity4 after surgery. In group L, there were @entity3 (1/13) and desaturation (1/13). In group ML, there were desaturation (1/14) and post-operative @entity2 (1/14). None in both groups developed @entity7 or @entity5 . A single-dose of @entity9 induced sedation only in 4 neonates, while combination of @entity8 and @entity9 in 11. None had elevation of either total or unbound @entity4 after surgery. In conclusion, the titrated dose of @entity8 with @entity9 is useful for anesthetic induction of neonates, although cares should be taken on its adverse effects such as @entity3 , desaturation, and post-operative @entity2 .

title: [ XXXX for anesthetic induction in neonates].

answer: @entity8


abstract: OBJECTIVE: To determine the management of @entity0 with new onset @entity3 by Canadian family physicians. METHODS: A survey was mailed to 195 family physicians in August 1995 to identify how they manage @entity3 in @entity0 according to four scenarios: based on presenting symptoms alone; assuming @entity2 -positive; known to be @entity2 -negative; and endoscopically confirmed @entity3 . RESULTS: A total of 170 of 195 physicians (87.2%) completed the survey. Physicians reported that 7.3% of their practice is devoted to @entity3 and 23% of these dyspeptic @entity0 present for the first time. Ninety-three per cent of family physicians find a symptom classification of ulcer-, reflux- and @entity5 -like @entity3 helpful. The majority of @entity0 are advised to make life-style changes and are treated with antacids or empiric drug therapy. A H2 receptor antagonist was the drug of choice for @entity1 , while prokinetics were often used for reflux and @entity5 -like @entity3 . After failure of initial treatment, @entity0 were given another course of empiric treatment, commonly with @entity4 or @entity6 . Family physicians estimated that the mean time to obtain a gastrointestinal consult was five weeks, and 70% indicated that this time to consult adversely influenced their decision to refer. If this time was reduced to less than two weeks, responding physicians would consider referring all eligible @entity0 . On average, two to 2.5 courses of empiric therapy were given before referral. If @entity2 status was known, fewer empiric treatments (mean 1.8) were given before gastroenterological referral compared with the other scenarios. If the @entity0 had @entity3 , 30% of family physicians provided reassurance only and did not prescribe empiric drug treatment. CONCLUSIONS: Most newly dyspeptic @entity0 in Canada are treated with empiric therapy according to symptom classification and referred for endoscopy after an average two to 2.5 treatment courses.

title: A Canadian physician survey of XXXX management.

answer: @entity3


abstract: @entity9 has been recently characterised as one of the strongest circulating vasoconstrictor peptides, its elevated level may cause @entity8 and increase of peripheral vascular resistance. All this contributes to @entity1 @entity3 and decrease of regional and global left ventricular function. The aim of the study was the examination of @entity9 plasma levels in @entity0 with @entity5 ( @entity5 ) after thrombolytic therapy with or without reperfusion. The survey was made in 82 @entity0 with @entity5 after thrombolytic therapy: 40 of them without reperfusion and 42 with reperfusion. The control group consisted of 20 healthy @entity0 . Plasma levels of @entity9 were measured before thrombolysis, then 1, 3 and 5 days after, using a radioimmunologic method. All @entity0 were treated with @entity2 , @entity7 and thrombolytic therapy (TT) with alteplase (r-TPA). In @entity0 with @entity5 , @entity9 plasma levels were normal before and 1 day after TT, and were significant elevated 3 days after TT 5 days after TT, plasma @entity9 levels were still high in @entity0 without reperfusion, but they decreased in @entity0 with reperfusion. There was significant negative correlation between @entity9 level and left ventricular ejection fraction measured 5 days after @entity5 . During 30-days follow up @entity4 of left ventricle with ejection fraction under 40% occurred in 21 @entity0 and in 11 of them clinical symptoms of @entity6 were observed. Using the multivariable regression analysis we showed that @entity9 concentration over 60 pg/ml is the independent factor leading to @entity4 . The results of our study suggest the contribution of @entity9 to the left ventricular remodeling after @entity5 .

title: [Plasma levels of neuropeptide Y i XXXX with current @entity5 ].

answer: @entity0


abstract: BACKGROUND: Left and right @entity4 can display different clinical, pathologic, and genetic characteristics. The purpose of this study was to characterize multiple molecular genetic alterations in sporadic @entity4 and to correlate them with the location of the @entity2 and with lymph node @entity1 . METHODS: One hundred and twenty-five cases of sporadic @entity4 (50 in the right colon and 75 in the left colon in @entity0 with no family history of @entity4 ) were studied. Status of the @entity5 gene was assessed by polymerase chain reaction (PCR), single strand conformation polymorphism, and sequencing at exons 5-8. @entity3 was analyzed with five microsatellite markers at chromosome 18. The mismatch repair genes @entity7 and @entity6 were studied in @entity2 found to have microsatellite instability by PCR and sequencing. RESULTS: In the 125 cases studied, there were 53 @entity2 with mutations of the @entity5 gene. @entity5 mutations correlated with lymph node @entity1 from right @entity4 cases (61%), and all cases with @entity5 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right @entity4 cases the rate of microsatellite instability was related to the @entity2 size (19% in @entity2 measuring < 4 cm, and 34% in @entity2 measuring > 4 cm). No correlation between microsatellite instability and @entity5 mutations was detected. In the left @entity4 cases, @entity5 mutations were detected in 41% of @entity2 and microsatellite instability in 14%; neither finding was related to the @entity2 size. Mutations of the @entity7 and @entity6 mismatch repair genes were detected in 7 of 24 cases with marked microsatellite instability. CONCLUSIONS: @entity3 is prone to occur in sporadic right @entity4 during @entity2 growth and is not associated significantly with mutations in the @entity7 and @entity6 mismatch repair genes or in the @entity5 gene. Concomitant detection of microsatellite instability and @entity5 mutations in right @entity4 is associated with the presence of lymph node @entity1 .

title: @entity3 and XXXX mutations in sporadic right and left @entity4 : different clinical and molecular implications.

answer: @entity5


abstract: In order to explore the interactions between @entity6 and @entity7 , in silico methodologies such as docking and 3D-QSAR were performed. CoMFA and CoMSIA analyses were done using ligand based and receptor guided alignment schemes. Validation statistics include leave-one-out cross-validated R(2) (q(2)), internal prediction parameter by progressive scrambling (Q(*2)), external prediction with test set. They show that models derived from this study are quite robust. Ligand based CoMFA (q(2) = 0.747, Q(*2) = 0.639, r(pred)(2)=0.802) and CoMSIA model (q(2) = 0.810, Q(*2) = 0.676, r(pred)(2)=0.785) were developed using atom by atom matching. Receptor guided CoMFA (q(2) = 0.712, Q(*2) = 0.497, r(pred)(2) = 0.841) and for CoMSIA (q(2) = 0.805, Q(*2) = 0.589, r(pred)(2) = 0.937) models were developed by docking of highly active @entity8 into the proposed NBD ( @entity1 binding domain) of @entity7 . The 3D-QSAR models generated here predicted that hydrophobic and steric parameters are important for activity toward @entity7 . Our studies indicate the important @entity2 in NBD crucial for binding in accordance with the previous results. This site forms a hydrophobic site. Since @entity5 have potential without @entity0 , we propose to inspect this hydrophobic site including @entity4 1043 and @entity3 1049 should be considered for future inhibitor design.

title: Docking and 3D-QSAR (quantitative structure activity relationship) studies of XXXX , the potent inhibitors of p-glycoprotein targeting the @entity1 binding domain.

answer: @entity6


abstract: 1. @entity7 promotes @entity5 and @entity9 through the activation of the B(2) receptor. The neuroprotective effect of LF 16-0687 Ms, a B(2) receptor antagonist, has been described when given prior to induction of transient focal @entity10 in @entity1 , but there are no data regarding the consequence of a treatment when given after injury. Therefore, in a @entity0 model of transient @entity8 ( @entity8 ), we evaluated the effect of LF 16-0687 Ms given prior to and/or after the onset of @entity3 on @entity2 , @entity6 volume and inflammatory responses including @entity9 , blood-brain barrier (BBB) disruption and neutrophil accumulation. 2. LF 16-0687 Ms (1, 2 and 4 mg kg(-1)) administered 0.5 h before and, 1.25 and 6 h after @entity8 , decreased the @entity6 volume by a maximum of 33% and significantly improved the neurological recovery. 3. When given at 0.25 and 6.25 h after @entity8 , LF 16-0687 Ms (1.5, 3 and 6 mg kg(-1)) decreased the @entity6 volume by a maximum of 25% and improved the neurological score. 4. Post-treatment with LF 16-0687 Ms (1.5 mg kg(-1)) significantly decreased @entity9 (-28%), BBB disruption (-60%) and neutrophil accumulation (-65%) induced by @entity3 . Physiological parameters were not modified by LF 16-0687 Ms. 5. These data emphasize the role of @entity7 B(2) receptor in the development of @entity11 , @entity2 and inflammatory responses resulting from transient focal @entity10 . Therefore, B(2) receptor antagonist might represent a new therapeutic approach in the pharmacological treatment of @entity4 .

title: LF 16-0687 Ms, a bradykinin B2 receptor antagonist, reduces @entity10 in a @entity0 model of transient focal XXXX .

answer: @entity10


abstract: BACKGROUND: @entity3 is a potentially devastating complication following @entity5 . The purpose of this study was to retrospectively identify risk factors for, and the prognosis associated with, a @entity3 following primary @entity5 . METHODS: Between 1970 and 2000, 27,004 primary total hip arthroplasties were performed at our institution. Forty-seven @entity0 (0.17%) with @entity1 were identified by a review of the complications log of a total joint database. The medical record of each @entity0 provided the data for this study. The average age of the @entity0 was fifty-seven years at the time of surgery. The @entity0 had serial clinical examinations for a minimum of two years, or until neurologic recovery or death. The @entity3 were classified as complete or incomplete, and only @entity0 with objective motor weakness were included in the study. The limb lengths were measured on preoperative and postoperative radiographs, and those data were then compared with the limb lengths in a matched cohort of @entity0 who had not sustained a @entity2 after a primary @entity5 . The extent of neurologic recovery, the need for braces or walking aids, and the use of medications for @entity4 were evaluated. RESULTS: There were twenty-nine complete @entity3 (sixteen peroneal, eleven sciatic, and two femoral) and eighteen incomplete @entity3 (fourteen peroneal, three sciatic, and one femoral). A preoperative diagnosis of @entity5 (p = 0.0004) or posttraumatic @entity6 (p = 0.01), the use of a posterior approach (p = 0.032), lengthening of the extremity (p < 0.01), and cementless femoral fixation (p = 0.03) were associated with a significantly increased odds ratio for the development of a postoperative @entity3 . Of the twenty-eight @entity0 with a complete palsy who were available for follow-up, only ten (36%) had complete recovery of motor strength, which took an average of 21.1 months. Seven of the eighteen @entity0 with an @entity7 fully recovered their preoperative strength. Twenty-one @entity0 required walking aids, and fifteen required permanent use of an ankle-foot orthosis. Five @entity0 required daily medication for chronic @entity4 . CONCLUSIONS: @entity3 is uncommon following primary @entity5 . A preoperative diagnosis of @entity5 or posttraumatic @entity6 , the use of a posterior approach, lengthening of the extremity, and use of an uncemented femoral implant increased the odds ratio of sustaining a @entity3 . The majority of the @entity8 in our series, whether complete or incomplete, did not fully resolve.

title: XXXX following primary @entity5 .

answer: @entity3


abstract: Eleven @entity0 treated at the University of Texas M. D. Anderson @entity1 Center for recurrent disease after resection of a stage I @entity2 of low malignant potential (SNLMP) are reported. At the time of diagnosis, the age of the @entity0 ranged from 26 to 43 years (mean 33). Seven @entity0 had stage IB @entity1 and 4 had stage IA @entity1 . All @entity0 were treated with a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The size of the @entity2 ranged from 4 to 15 cm in maximum dimension. Stromal microinvasion was seen in 2 cases, and foci of @entity5 were seen in the peritoneum in 8 cases. Nine @entity0 were treated with radiotherapy and 2 with chemotherapy. The time to recurrent disease ranged from 7 to 39 years (mean 16). @entity1 recurred in the pelvis or abdomen, 2 in the neck with subsequent abdominal involvement, and 1 in the pleura without abdominal or pelvic involvement. In 10 cases, the recurrent @entity1 were @entity3 , and in 1 case it was a SNLMP. Recurrences were treated with chemotherapy in 10 cases and with hormones in 1 case. Seven @entity0 died of progressive @entity3 2 to 5 years after the recurrence. One @entity0 died of @entity4 with recurrent @entity2 10 years after the recurrence was detected. Two @entity0 are alive with progressive disease 1 and 7 years after the recurrence, and 1 @entity0 whose disease recurred as a SNLMP is alive with no evidence of disease 9 years after the recurrence. These 11 @entity0 were compared with 16 @entity0 who had stage I ovarian SNLMPs that did not recur after a minimum follow-up of 15 years. There was no difference in the age of the @entity0 , gravidity, size of the @entity1 , or several microscopic parameters, including degree of epithelial proliferation, number of mitoses, and nuclear atypia. Microinvasion was found in one case. The only significant difference between the two groups was the low frequency of @entity5 in the cases that had no disease recurrences (12.5% versus 72.7%). In summary, we found no clinical or pathologic features that can unequivocally predict the recurrence of stage I ovarian SNLMPs. Because of the long interval to recurrence, the fact that the recurrent @entity1 in 10 of 11 @entity0 were @entity3 , and the result of the X-chromosome inactivation in one case, the recurrent @entity1 could represent independent primaries or a slow progression of one clone present in the SNLMPs.

title: @entity1 recurrence in XXXX of low malignant potential.

answer: @entity2


abstract: UNASSIGNED: Limited research exists on how different oil types and time of addition affect starch digestibility of @entity1 . This study aimed to assess the starch digestibility of white and @entity2 prepared with 2 oil types: vegetable oil (unsaturated fat) and ghee (clarified butter, saturated fat) added at 3 different time points during the cooking process ("before": frying raw @entity1 in oil before boiling, "during": adding oil during boiling, and "after": stir-frying cooked @entity1 in oil). @entity2 produced a slower digestion rate than white @entity1 . White @entity1 digestibility was not affected by oil type, but was affected by addition time of oil. Adding oil "after" (stir-frying) to white or @entity2 resulted in higher slowly digestible starch. @entity2 cooked using ghee showed the lowest amount of @entity0 release during in vitro digestion. The addition of ghee "during" (that is boiling with ghee) or "before" (that is frying @entity1 raw with ghee then boiling) cooking showed potential for attenuating the postprandial glycemic response and increasing resistant starch content. This is the first report to show healthier ways of preparing @entity1 . White @entity1 with oil added "after" (stir-fried) may provide a source of sustained @entity0 and stabilize blood @entity0 levels. Boiling @entity2 with ghee or cooking @entity2 with ghee pilaf-style may provide beneficial effects on postprandial blood @entity0 and insulin concentrations, and improve colonic health. The encouraging results of the present study justify extending it to an in vivo investigation to conclusively determine the effect of time of addition of fat when @entity1 is cooked on blood @entity0 homeostasis.

title: The Glycemic Potential of White and XXXX Affected by Oil Type and Time of Addition.

answer: @entity2


abstract: UNASSIGNED: We aimed to characterize genotype-phenotype correlations and establish baseline clinical data for @entity7 caused by mutations in the @entity9 ( @entity9 ) gene. @entity9 mutations are the second leading cause of @entity8 . Recent research makes clinical trials for @entity0 with @entity9 mutations a realistic possibility. However, the clinical severity varies with different mutations and natural history data on progression is sparse. We present cross-sectional data to begin to define the phenotypic spectrum and clinical baseline of @entity0 with these mutations. A cohort of @entity0 with @entity9 gene mutations was identified in 13 centres of the @entity3 Consortium - Rare Disease Clinical Research Consortium (INC-RDCRC) between 2009 and 2012 and at Wayne State University between 1996 and 2009. @entity0 phenotypes were quantified by the @entity1 score version 1 or 2 and the @entity8 paediatric scale outcome instruments. Genetic testing was performed in all @entity0 and/or in first- or second-degree relatives to document mutation in @entity9 gene indicating diagnosis of @entity8 . There were 103 @entity0 from 71 families with 47 different @entity9 mutations with a mean age of 40 years (range 3-84 years). @entity0 and mutations were separated into infantile, childhood and adult-onset groups. The infantile onset group had higher @entity1 score version 1 or 2 and slower nerve conductions than the other groups, and severity increased with age. Twenty-three @entity0 had no family history of @entity8 . Sixty-one @entity0 wore foot/ankle orthoses, 19 required walking assistance or support, and 10 required wheelchairs. There was @entity4 in 21 and @entity6 in 17. Forty-two @entity0 did not begin walking until after 15 months of age. Half of the infantile onset @entity0 then required ambulation aids or wheelchairs for ambulation. Our results demonstrate that virtually all @entity9 mutations are associated with specific phenotypes. Early onset (infantile and childhood) phenotypes likely represent developmentally impaired myelination, whereas the adult-onset phenotype reflects @entity5 without antecedent @entity2 . Data from this cohort of @entity0 will provide the baseline data necessary for clinical trials of @entity0 with @entity8 caused by @entity9 gene mutations.

title: Genotype-phenotype characteristics and baseline natural history of heritable XXXX caused by mutations in the @entity9 gene.

answer: @entity1


abstract: The penetration of blood vessels in the @entity2 causes a reduction of transparency and as a @entity1 or even @entity5 . MATERIALS AND METHODS: Experiments were conducted on 120 New Zealand albino @entity0 , separated into different groups. Doses of vasculogenic alkalis provoked burning of the corneas. The following methods were used: Split-lamp investigation of the @entity2 with @entity3 , @entity3 angiography of the corneal neovessels, light and electron microscopy. Left eyes served as a control. Right eyes were treated with heparin and @entity4 , @entity8 , prooxygens and antioxidants. RESULTS: Application of heparin and @entity4 reversibly inhibited the process of neoangiogenesis but intensified the corneal ulcer. The application of @entity8 stimulated angiogenesis in the @entity2 . Electron microscopic observations showed the generation of transport pathways through the walls of neovessels. The basement membrane of the neovessels was formed nearly 4 - 5 months after their growth. @entity3 angiography showed first increased permeability from the walls of the neovessels and, 4 - 5 months later, poor penetration of the @entity3 through the vessels walls. CONCLUSIONS: The application of inhibitors of neoangiogenesis decreases the repair processes in corneal lesions with initial @entity6 . The angiogenic factors are distributed by diffusion in the @entity7 and neovessels initiate from the nearest limbic vessels. With the support of @entity3 angiography we can specify the time of their formation. The process of regression of the neovessels should be investigated.

title: [Neovascularisation of the XXXX ].

answer: @entity2


abstract: @entity0 deprivation for prolonged periods leads to cardiac cell death and @entity1 . The ability to prevent @entity3 would be of significant therapeutic value in maintaining cardiac function after injury. While caspases have been suggested to play a critical role in apoptosis, their involvement during @entity2 has not been formally determined. In this report, we show that adult ventricular myocytes subjected to @entity5 for 1 h undergo a three-fold increase (P<0.05) in the incidence of apoptosis as determined by TUNEL analysis and @entity7 nuclear staining. Western blot analysis of @entity5 myocytes revealed a 10-fold increase in the proteolytic processing of @entity6 to @entity12 with a concomitant cleavage of the @entity6 substrate @entity11 from 116 kd to @entity9 kd compared to normoxic controls. Defects in mitochondrial membrane integrity were also observed as evidenced by the translocation of @entity8 from the mitochondrial to cytosolic compartment of @entity5 cells. Pretreatment of ventricular myocytes with the peptide-caspase inhibitor known to block caspases related to @entity10 (Ac-YVAD- @entity4 ) attenuated @entity8 release, processing of @entity6 , and apoptosis. While the caspase inhibitor (Ac-DEVD- @entity4 ) which blocks caspases related to @entity6 , suppressed the cleavage of @entity11 and apoptosis, it had no effect on @entity8 release by mitochondria. The data provide direct evidence for the proteolytic activation of caspases during @entity5 -mediated apoptosis of adult ventricular myocytes. Furthermore, the data suggest a hierarchical scheme for caspase activation with mitochondrial @entity8 release occurring proximally to DEVD- @entity4 -inhibitable caspases.

title: Caspase activation and mitochondrial XXXX release during @entity5 -mediated apoptosis of adult ventricular myocytes.

answer: @entity8


abstract: The introduction of @entity7 kinase inhibitor (TKI) therapy has markedly reduced the use of allogeneic (allo) hematopoietic stem cell transplantation (HSCT), which is no longer standard practice in the first chronic phase in @entity6 and is currently reserved after failure of TKI or in advanced phase of disease. We compared the outcome of @entity6 @entity0 who received a first allo-HSCT in our center in both the pre-TKI era and the TKI era. The primary end point was to compare the 2 groups' @entity3 ( @entity3 ), @entity5 ( @entity5 ), cumulative incidence of nonrelapse mortality, and relapse incidence. The secondary end point was to underline in the TKI era the impact of the pretransplantation @entity2 ( @entity2 ) on the outcomes. A total of 69 @entity0 with Ph+ @entity5 were included and their outcomes analyzed. For the purpose of this analysis, we defined 2 groups: group A (n  = 39) included @entity0 treated in the pre-TKI era, treated from January 1989 until December 2001, and group B (n  = 30) included @entity0 treated in the TKI era, treated from January 2002 until December 2013. Additional analysis was performed in group B for whom detailed TKIs and @entity2 data were collected. The study took place in our @entity1 center in the department of HSCT, Villejuif, France. The median follow-up duration for group A was 116.1 months (range, 1.1 to 240.1 months) and for group B was 8.3 months (range, 3.5 to 141.7 months). At 3  years, the @entity5 and @entity3 were higher in group B (respectively, 66% and 71%) than in group A (respectively, 63% and 57%) (P > .05). The @entity5 and @entity3 at 3 years of the pretransplantation @entity2 -negative (< 0.01%) @entity0 were significantly (P  < .05) higher (respectively, 83% and 94%) than the pretransplantation @entity2 -positive @entity0 (respectively, 43% and 46%). Our data, although statistically not significant, suggest better outcomes for Ph+ @entity5 @entity0 undergoing allo-HSCT in the TKI era. Mostly TKI does not adversely affect the transplantation outcomes and can be used successfully as a bridge to allo-HSCT, especially in @entity4 . In addition, we highlight the importance of obtaining deep pretransplantation @entity2 negativity.

title: Retrospective Study of Allogeneic Hematopoietic Stem Cell Transplantation in Philadelphia XXXX : 25 Years' Experience at Gustave Roussy Cancer Campus.

answer: @entity5


abstract: BACKGROUND: Ideally, percutaneous, mechanical closure of defects of the atrial septum should completely resolve shunt. To achieve this goal, more information is needed about the factors associated with device failure. METHODS: Consecutive @entity0 with cryptogenic neurological events who had severe baseline Valsalva shunt (Spencer Grade 5-5+) and intracardiac echocardiography (ICE) defined @entity2 ( @entity2 ) who underwent percutaneous @entity2 closure with the GORE(  ) HELEX Septal Occluder device were evaluated for residual 3-month shunt by transcranial Doppler (TCD). RESULTS: We closed 315 @entity2 @entity0 with the HELEX devices: 15, 20, 25, 30 mm devices in 19, 138, 150, and 8 @entity0 , respectively. Severe residual Valsalva shunt (TCD Grade 5-5+) at 3 months occurred in 23 of 315 (7%) of all @entity0 and in 2 of 108 (2%), 5 of 86(6%), and 16 of 121 (13%) @entity0 with none, Grade 4, and Grade 5-5+ baseline rest shunt, respectively (P = 0.002). At 3 months, rest shunting was essentially abolished by closure. The percent of @entity0 with severe residual Valsalva shunt was also related to device size: 15 mm (0%), 20 mm (4%), 25 mm (10%), and 30 mm (25%) (P = 0.008) and to @entity1 . All of these variables were independent predictors of failure by multivariate logistic regression. CONCLUSIONS: In an ICE-defined @entity2 population characterized by severe baseline Valsalva shunt and a high incidence of persistent (rest) shunting, the GORE(  ) HELEX Septal Occluder device effectively reduces both provoked and persistent shunt. The causes of device failure are multifactorial. Larger devices perform less reliably suggesting the need for size-specific modifications to improve closure of more severe defects. (J Interven Cardiol 2011;24:366-372).

title: Transcranial doppler quantification of residual shunt after percutaneous XXXX closure: efficacy of the GORE(  ) HELEX septal occluder.

answer: @entity2


abstract: PURPOSE. To evaluate outcomes of wide resection and reconstruction of the distal radius with non-vascularised autogenous fibular grafts for @entity1 ( @entity1 ) of bone. METHODS. Medical records of 7 @entity0 and 5 @entity0 aged 22 to 47 (mean, 31) years who underwent wide resection of the distal radius and reconstruction with non-vascularised autogenous fibular grafts for @entity1 of bone were reviewed. The mean length of the resected radius was 9 (range, 7-11) cm. The ipsilateral proximal fibula with a small portion of attached ligament was harvested. The articular surface of the graft was fixed to the scapholunate articular surface by Kirschner wires, and the ligament of the fibular head was sutured to the carpal ligaments. The graft was fixed to the proximal radius with a small dynamic compression plate. Iliac cancellous bone graft was added. @entity2 , instability, and functional status were assessed. Wrist joint movements were measured using a goniometer. The grip strength was measured. The operated and contralateral sides were compared. RESULTS. The mean follow-up was 24 (range, 20-27) months. All @entity0 achieved radiological union after a mean of 16 (range, 14-20) weeks. The mean active range of movement in the operated wrists was 32   dorsiflexion, 38   palmar flexion, 15   radial deviations, 12   ulnar deviations, 50   supination, and 60   pronation. Compared with the contralateral wrists, the operated wrists regained 60% of the function, with satisfactory grip strength, and normal finger and thumb movements and hand sensation. No @entity0 had recurrence after 2 years. Two @entity0 had minor dorsal subluxation, which was resolved with a wrist brace. Three @entity0 had superficial infection, which was resolved with intravenous antibiotics and dressings. Two @entity0 had @entity3 , which recovered completely in 12 weeks. CONCLUSION. Non-vascularised fibular grafts for reconstruction of the distal radius after resection of a @entity1 of bone achieved good cosmetic and functional outcomes.

title: Reconstruction of the distal radius with non-vascularised fibular graft after resection of XXXX .

answer: @entity1


abstract: OBJECTIVE: To improve radiodiagnosis of @entity9 at pre- and postoperative treatment stages, to provide a rationale for detailed evaluation of orbital osseous and soft tissue structures to prevent @entity5 . MATERIAL AND METHODS: The I.M. Sechenov First Moscow State Medical University Clinic examined 52 (100%) @entity0 on days 1-2 after injury. A @entity0 group consisted of 49 (94%) @entity0 and 3 (6%) @entity0 whose age was 17 to 49 years. Multislice computed tomography (MSCT) was carried out prior to surgery on the day of their admission. Postoperative MSCT was done within 7-10 days after surgical treatment. RESULTS: Preoperative MSCT could reveal fractures of the inferior and lateral orbital walls in all 52 (100%) @entity0 . @entity4 of the medial and superior orbital walls were identified in 8 (15%) and 3 (6%) cases, respectively. In 12 (23%) @entity0 , prolapse of the fat and oculomotor muscles into the respective maxillary sinus was imaged, which gave rise to enophthalmos and an increase in orbital volume. Three (6%) @entity0 were identified as having sequels of eyeball @entity3 . @entity7 was detected in 11 (21%) @entity0 . @entity2 was encountered in 20 (38%) @entity0 . After surgical treatment, 4 (8%) @entity0 had a persistent inferior orbital wall defect in the posterior portions where the retrobulbar fat prolapsed into the maxillary sinus. Three (6%) out of the 20 (38%) @entity0 with different @entity6 had persistent postoperative @entity2 that were mainly associated with erroneous orbital floor implantation. The number of @entity0 with @entity1 remained unchanged--3 (6%). Among 11 (21%) @entity0 with a postoperative pathologically changed tortuous nerve course, the optic nerve attained its correct even course all the way in 5 (10%) cases; it remained pathologically changed as before in 6 (12%) cases. CONCLUSION: MSCT is the preoperative technique of choice for examining @entity0 with @entity8 . After surgery, MSCT in the early postoperative period makes it possible to assess the results of treatment and to reveal possible complications and it is a decisive guide for a doctor in charge when planning resurgery.

title: [Multislice computed tomography in the diagnosis of XXXX ].

answer: @entity9


abstract: Psoriasis is a chronic @entity5 characterized by excessive proliferation and abnormal keratinocyte development, in which T helper type 17 cells and @entity12 ( @entity12 ) activation have pivotal roles. Moreover, caveolin-1 ( @entity11 -1) has been implicated in the regulation of signal transduction, and aberrant @entity11 -1 expression is involved in a variety of diseases. However, whether @entity11 -1 is involved in @entity10 is unknown. Here we examined @entity11 -1 expression in the psoriatic epidermis and investigated its role in the pathogenesis of @entity10 . @entity11 -1 was markedly reduced in lesional epidermis of @entity10 @entity0 . @entity15 silencing in keratinocytes in vitro revealed significant activation of @entity12 , leading to increased expression of @entity16 and several cytokine/chemokines, such as @entity8 , @entity9 ( @entity9 ), @entity7 , and C-C chemokine ligand 20. In addition, @entity10 -related cytokines, including @entity1 @entity4 factor-a ( @entity6 ), decreased @entity11 -1 expression in keratinocytes. Finally, administration of @entity11 -1 scaffolding domain peptide in a @entity2 model of @entity10 -like @entity3 induced by imiquimod improved the skin phenotype and reduced epidermal thickness and infiltrating cell counts. Furthermore, expression of @entity6 , @entity13 , and @entity14 was significantly suppressed by this treatment. Collectively, our study indicated that @entity11 -1 participates in the pathogenesis of @entity10 by regulating the @entity12 pathway and cytokine networks.

title: Decreased Expression of Caveolin-1 Contributes to the Pathogenesis of Psoriasiform Dermatitis in XXXX .

answer: @entity2


abstract: BACKGROUND: @entity7 ( @entity7 ) is a rare @entity1 that commonly affects young individuals without a prior history of @entity3 . The principal differential diagnosis is conventional hepatocellular @entity2 especially the scirrhous variant. Despite their distinctive appearance, recent studies have demonstrated a lack of consistency in how @entity7 are diagnosed by pathologists. AIM: To investigate the diagnostic utility of @entity4 in differentiating between @entity7 and @entity1 . @entity0 AND METHODS: In our retrospective study, we reviewed four cases of @entity7 that were diagnosed at the pathology department of Mongi Slim hospital over a thirteen-year period (2002-2014). Relevant clinical information and microscopic slides were available in all cases and were retrospectively reviewed. Immunohistochemical analysis was performed using the avidin- @entity5 complex technique with antibodies against @entity4 and @entity6 . RESULTS: Our study group included one @entity0 and three @entity0 (sex ratio M/F   =   0.33) aged between 23 and 34 years (mean   = 28  years). All cases arose in non-cirrhotic liver. Immunohisto chemically, all cases were positive for @entity6 and for @entity4 (n   =   4). CONCLUSIONS: @entity4 immunostaining is a sensitive marker for @entity7 that may be of use in routine diagnostic surgical pathology. Lack of @entity4 staining should suggest caution in making a diagnosis of @entity7 .

title: @entity2 versus XXXX   : diagnostic usefulness of @entity4 .

answer: @entity1


abstract: The low prevalence of @entity6 in premenopausal @entity0 and its increase after menopause are well established. Although @entity4 is thought to play a role in protecting the vasculature, the mechanism has not been fully clarified. The contribution of platelets to atherosclerotic @entity2 is well recognized. The present study focused on the still-controversial effect of @entity4 on platelet function. We investigated the in vitro effects of @entity4 on @entity0 platelets, including their aggregation, @entity3 metabolism, the synthesis of @entity14 , and NO ( @entity11 / @entity10 ) synthesis after stimulation with @entity7 or @entity8 . Pretreatment of platelets with @entity1 reduced the @entity9 induced by @entity7 or @entity8 , whereas @entity15 had no effect. @entity1 accelerated the recovery of [ @entity3 ]i after the agonist-induced peak and reduced the area under the curve of accumulated platelet [ @entity3 ]i but did not alter the baseline [ @entity3 ]i, @entity3 influx induced by @entity7 or @entity8 , the release of @entity3 from internal stores, or the size of internal @entity3 stores. Pretreatment of platelets with @entity1 had no effect on the intracellular concentration of @entity5 but increased that of cGMP in agonist-stimulated platelets. Additionally, @entity1 increased the platelet concentration of @entity11 / @entity10 in a dose-dependent manner. These effects of @entity1 on @entity9 , @entity3 metabolism, and NO synthesis were abolished by exposure to @entity13 , an NO synthesis inhibitor. These results suggest that @entity1 plays an important role in inhibiting @entity9 by promoting @entity3 extrusion or reuptake activity that is dependent on the production of @entity12 by increasing NO synthesis.

title: Effect of @entity1 on inhibition of XXXX in vitro is mediated by an increase in NO synthesis.

answer: @entity9


abstract: BACKGROUND: @entity3 ( @entity3 ) is one of the most common congenital @entity1 and began to get treated by transcatheter occlusion since 1997 in China. Since then, several devices have been invented for occluding @entity3 . This study aimed to evaluate the technical feasibility, safety, and efficacy of transcatheter occlusion of @entity3 with different devices. METHODS: One thousand five hundred and twenty-six @entity0 (537 @entity0 , 989 @entity0 ) with @entity3 from January 1997 to September 2014 underwent descending aortogram and transcatheter occlusion procedure. We retrospectively analyzed data of these @entity0 , including gender, age, weight, size and morphology of @entity3 , and devices used in transcatheter occlusion, outcomes, and postoperational complications. RESULTS: Median age and median weight were 4.0 years (range: 0.3-52.0 years old) and 15.3 kg (range: 4.5-91.0 kg), respectively. Mean ductal diameter, aortic ductal diameter, ductal length, and pulmonary artery pressure were 3.50    2.15 mm, 10.08    2.46 mm, 7.49    3.02 mm, and 30.21    17.28 mmHg, respectively. Morphology of @entity3 assessed by descending aortogram was of type A in 1428 @entity0 , type B in 6 @entity0 , type C in 79 @entity0 , type D in 4 @entity0 , and type E in 9 @entity0 according to the classification of Krichenko. Of all the 1526 @entity0 , 1497 @entity0 underwent transcatheter @entity3 closure, among which 1492 were successful. Devices used were Amplatzer duct occluder I (ADO I, 1280, 85.8%), Cook detachable coils (116, 7.8%), ADO II (ADO II, 68, 4.6%), muscular @entity2 occluder (12, 0.8%), and Amplatzer vascular plug (16, 1.0%). CONCLUSIONS: Excellent occlusion rates with low complication rates were achieved with all devices regardless of @entity3 types. With transcatheter occlusion technique and devices developing, more @entity0 with @entity3 can be treated with transcatheter closure both safely and efficiently.

title: A Retrospective Study of 1,526 Cases of Transcatheter Occlusion of XXXX .

answer: @entity3


abstract: BACKGROUND: @entity2 is a rare but highly lethal malignancy. Historically, radical resection was considered the "gold standard" for treatment of potentially curable @entity2 . The dismal prognosis of this disease has prompted us to recommend wide local excision as the initial therapeutic approach. The purpose of this study was to review our results in @entity0 who underwent wide local excision or radical surgery (abdominoperineal resection [APR]) for localized @entity2 . STUDY DESIGN: We reviewed the charts of all @entity0 referred for resection of @entity2 between 1988 and 2002. Endpoints included overall survival, disease-free survival, and local, regional, or systemic recurrence. RESULTS: Fifteen @entity0 underwent curative-intent surgery; four underwent APR and 11 underwent wide local excision. Eight @entity0 (53%) are alive; 7 (47%) are disease-free (followup 6 months to 13 years). Of 12 @entity0 who have been followed for more than 2 years, 4 are alive (33%) and 3 are disease-free (25%). Seven @entity0 have been followed for more than 5 years and two are alive and disease-free (29%). All of the longterm survivors underwent local excision as the initial operation. There were no differences in local recurrence, systemic recurrence, disease-free survival, or overall survival between the APR group and the local excision group. Local recurrence occurred in 50% of the APR group and 18% of the local excision group; regional recurrence occurred in 25% versus 27%. Distant @entity1 were common (75% versus 36%). CONCLUSION: In @entity0 who have undergone resection with curative intent for @entity2 , most recurrences occur systemically regardless of the initial surgical procedure. Local resection does not increase the risk of local or regional recurrence. APR offers no survival advantage over local excision. We advocate wide local excision as primary therapy for @entity2 when technically feasible.

title: Surgical therapy for XXXX .

answer: @entity2


abstract: OBJECTIVE: To compare the effectiveness of @entity4 , @entity1 , and @entity2 in the treatment of idiopathic @entity3 . DESIGN: Prospective randomized clinical study. SETTING: University hospital. @entity0 (S): Forty-one @entity0 (median age, 21 years [range, 18-34 years]) with idiopathic @entity3 who had requested to use an oral contraceptive. INTERVENTION(S): @entity0 were randomly assigned to receive @entity4 (12.5 mg/d for the first 10 days of the cycle), @entity1 (5 mg/d), or @entity2 (100 mg/d) for 12 months. Follow-up was done at the end of therapy. MAIN OUTCOME MEASURE(S): Ferriman-Gallwey score before treatment, at 6 and 12 months of treatment, and 1 year after the end of treatment, and androgenic profile before and after treatment. RESULT(S): At the end of therapy, the Ferriman-Gallwey score decreased by 38.9%, 38.6%, and 38.5% in @entity0 who used @entity4 , @entity1 , and @entity2 , respectively. One year after therapy, the Ferriman-Gallwey score of @entity0 who used @entity2 was significantly lower (6.74 +/- 1.41) than that of @entity0 who used either @entity4 (7.92 +/- 1.08), or @entity1 (9.08 +/- 0.99). The androgenic profile did not change significantly during treatment. CONCLUSION(S): In @entity0 with idiopathic @entity3 , the short-term results of treatment with @entity4 , @entity1 , and @entity2 are similar, but @entity2 is effective for a longer time.

title: Use of @entity4 , @entity1 , and @entity2 to treat idiopathic XXXX .

answer: @entity3


abstract: By targeting the expression of sequences encoding non-milk proteins to the mammary gland of transgenic farm animals, the organ could serve as a 'bioreactor' for producing pharmacologically active proteins on a large scale. Here we report the generation of transgenic @entity2 bearing a fusion gene construct with the @entity0 @entity5 factor @entity3 ( @entity4 ) cDNA under the transcriptional control of a 2.2 kb fragment of the mammary gland specific promoter of the ovine beta-Lactoglobulin (beta-Lac) gene. Six founder animals were generated bearing a @entity4 cDNA construct with the introns of the @entity1 @entity6 ( @entity6 ) gene (beta-Lac/ @entity4 - @entity6 ). Founders transmitted the transgene in a Mendelian fashion and two transgenic lines were generated. Ten out of 12 transgenic F1-females expressed rhFVIII mRNA in exfoliated mammary epithelial cells isolated from the milk. But only in transgenic F1 ewes 4010 and 603 @entity4 clotting activity estimated at 4-6 ng/ml was detected in defatted milk. Furthermore, the presence of rhFVIII-protein in ovine milk was demonstrated by a specific band at approximately 190 kD following immunoprecipitation and immunoblotting. Transgenic founder 395 expressed rhFVIII mRNA in biopsied mammary gland tissue, in exfoliated mammary cells as well as ectopically in brain, heart, spleen, kidney and salivary gland, suggesting that the employed beta-Lac promoter fragment lacks essential sequences for directing expression exclusively to the mammary gland. A rhFVIII standard preparation (rhFVIIIstd) was rapidly sequestered in a saturable fashion in ovine milk, thus rendering it largely inaccessible to immunoprecipitation although its biological activity was retained. Recovery of hFVIIIstd was dependent on milk donor, storage temperature and dilution of milk sample.

title: Expression of @entity0 @entity5 factor @entity3 in the mammary gland of transgenic XXXX .

answer: @entity2


abstract: BACKGROUND: The heterogeneity of symptoms and @entity2 in @entity4 can be explained by abnormal connectivity between brain regions. @entity6 ( @entity6 ) is a particularly severe form of @entity4 , with an onset during a key time period for both cerebral pruning and myelination. METHODS: Diffusion tensor images were acquired from 18 @entity0 and adolescents with @entity6 and 25 controls. The @entity6 group was divided into two sub-groups-one with @entity2 ( @entity2 ) and the other without (NLI). The fractional anisotropy (FA), axial ( @entity5 ), and radial diffusivity (RD) data from the two @entity6 sub-groups were compared to each other and to the controls using tract-based spatial statistics (TBSS) analyses, which is a voxel-based method used to identify regions of @entity1 . RESULTS: TBSS identified several regions in the left hemisphere where the @entity2 group had increased @entity5 and RD relative to the NLI and the control groups. These areas primarily localized to linguistic tracts: left superior @entity3 . Regions of increased RD overlapped regions of increased @entity5 , with the former showing more pronounced effects. CONCLUSIONS: Studies of adult-onset @entity4 typically identify areas of higher RD but unchanged @entity5 ; however, normal development studies have shown that while RD decreases are pronounced over this age range, smaller decreases in @entity5 can also be detected. The observed increases in both RD and @entity5 suggest that developmental disturbances affecting the structural connectivity of these pathways are more severe in @entity6 accompanied by severe @entity2 .

title: White matter integrity, language, and childhood onset XXXX .

answer: @entity4


abstract: Estrogen triggers rapid yet transient activation of the MAPKs, @entity9 and @entity6 . We have reported that this estrogen action requires the G protein-coupled receptor, @entity11 , and occurs via Gbetagamma-subunit protein-dependent transactivation of the @entity2 through the release of pro-heparan-bound EGF from the cell surface. Here we investigate the mechanism by which @entity3 activity is rapidly restored to basal levels after estrogen stimulation. Evidence is provided that attenuation of @entity3 activity by estrogen occurs via @entity11 -dependent stimulation of adenylyl cyclase and @entity10 -dependent signaling that results in @entity8 inactivation. We show that 17beta-E2 represses EGF-induced activation of the @entity7 -to- @entity6 pathway in @entity1 @entity0 cells that express @entity11 , including MCF-7 and SKBR3 cells which express both or neither, ER, respectively. MDA-MB-231 cells, which express @entity5 , but not @entity4 , and low levels of @entity11 protein, are unable to stimulate adenylyl cyclase or promote estrogen-mediated blockade of EGF-induced activation of @entity3 . Pretreatment of MDA-MB-231 cells with cholera toxin, which ADP-ribosylates and activates Galphas subunit proteins, results in G protein-coupled receptor (GPCR)-independent adenylyl cyclase activity and suppression of EGF-induced @entity3 activity. Transfection of @entity11 into MDA-MB-231 cells restores their ability to stimulate adenylyl cyclase and attenuate EGF-induced activation of @entity3 by estrogen. Moreover, @entity11 -dependent, @entity10 -mediated attenuation of EGF-induced @entity3 activity was achieved by ER antagonists such as tamoxifen or ICI 182, 780; yet not by 17alpha-E2 or progesterone. Thus, our data delineate a novel mechanism, requiring @entity11 and estrogen, that acts to regulate @entity3 activity via an inhibitory signal mediated by @entity10 . Coupled with our prior findings, these current data imply that estrogen balances @entity3 activity through a single GPCR via two distinct G protein-dependent signaling pathways that have opposing effects on the @entity2 -to-MAPK pathway.

title: Estrogen action via the G protein-coupled receptor, @entity11 : stimulation of adenylyl cyclase and @entity10 -mediated attenuation of the XXXX -to-MAPK signaling axis.

answer: @entity2


abstract: A phase II trial was performed to evaluate the efficacy and @entity1 of the novel combination of @entity7 and @entity8 as first-line chemotherapy in @entity0 with stages IIIB and @entity6 . From January 1997 to September 1999, 34 @entity0 (9 stage IIIB and 25 stage IV) received a regimen consisting of the following: @entity7 30 mg/m2 20 minutes intravenous (i.v.) infusion, days 1 and 8; and @entity8 135 mg/m2 3-hour i.v. (starting 1 hour after @entity7 ) on day 1. Cycles were repeated every 28 days until progression of disease or unacceptable @entity1 development. The median age was 57 years (range 41-70 years); median performance status was 1. Histology was as follows: squamous cell in 24 (71%), large cell in 1 (3%), and @entity3 in 9 (26%). All @entity0 are evaluable for @entity1 , whereas 30 are evaluable for response (4 @entity0 refused treatment). Objective response was recorded in 4 of 30 @entity0 (13%, 95% CI 1-25%). No complete response was observed. Partial response was recorded in 4 @entity0 (13%), no change in 10 @entity0 (34%), and progressive disease in 16 @entity0 (53%). The median time to treatment failure was 4 months and median survival was 9 months. The limiting @entity1 was myelosuppression: @entity10 in 23 @entity0 (68%), whereas @entity9 was observed in 25 @entity0 (78%). @entity11 developed in 14 @entity0 (41%) (without G3 or G4 episodes), and @entity5 (G1-G2: 10 @entity0 ), @entity4 (G1-G2: 11 @entity0 ), @entity2 (G1-G2: 7 @entity0 ), and @entity12 were observed in 7 @entity0 . @entity7 - @entity8 combination showed only modest activity against locoregionally advanced or metastatic NSCLC.

title: @entity7 and @entity8 for locoregional advanced or metastatic XXXX .

answer: @entity6


abstract: UNASSIGNED: 2507 Background: We have previously demonstrated that administration of a recombinant @entity3 /diphtheria toxin conjugate (DAB/ @entity3 ; ONTAK; Denileukin Diftitox) to @entity2 @entity0 transiently depletes T cells, including regulatory T cells, and promotes the expansion of @entity2 -specific effector T cells. The goals of this study were to examine the effects of DAB/ @entity3 on additional lymphocyte subsets, monocytes, neutrophils and @entity4 and assess clinical efficacy in stage IV @entity2 @entity0 . METHODS: We first administered DAB/ @entity3 (12   g/kg; daily x 4 days; 21 day cycles) to 10 stage IV @entity2 @entity0 and measured effects on lymphocyte subsets and myeloid-derived cells by flow cytometry and serum @entity4 by ELISA. We then determined objective response rates (using FDG-PET and CT) and one year survival in a total of 60 @entity0 given DAB/ @entity3 . RESULTS: We found that DAB/ @entity3 transiently depleted total lymphocytes, NK, B and T cells and conversely increased monocyte and neutrophil counts with a coincident increase in serum @entity4 (baseline, 0.54    0.27; day 7, 1.38    0.19 pg/ml, p value <0.01). 16.7% of @entity0 had partial responses, 5% stable disease and 15% mixed responses (83% of these @entity0 were pre-treated with 1-5 prior systemic regimens). However, 45.5% of the chemo/immune-na  ve @entity0 , the majority with visceral metastases (stage M1C), had partial responses including delayed @entity1 regressions and durable stability of residual metastases, indicating a potential immunotherapeutic mechanism. While the total 1 year survival was 40    6.2%, the partial responder 1 year survival was 80   11.9% ( p value < 0.001). CONCLUSIONS: Taken together, these data indicate that DAB/ @entity3 demonstrates significant clinical activity in chemo/immune-na  ve stage IV @entity2 @entity0 that may be due to a combination of transient depletion of multiple lymphocyte subsets including regulatory T cells, stimulation of @entity4 secretion and myeloid cell expansion. The high partial response rate in na  ve @entity0 coupled to the improved 1 year survival in responders supports the conduct of additional trials of DAB/ @entity3 for the treatment of @entity2 .

title: Effect of denileukin diftitox on serum XXXX and clinical responses in stage IV @entity2 .

answer: @entity4


abstract: OBJECTIVE: To study the changes of the clinical aspects of @entity2 ( @entity2 ) during the past 30 years. METHODS: The clinical data of 3,250 @entity0 with @entity2 , from 10 regions of China were collected, analyzed, and compared with the clinical data of 3254 @entity2 cases 30 years before. RESULTS: The 3,250 @entity0 were aged 1- 80, with an average age of 49.1 years, younger than those 30 years before (43.7 years). The male to female ratio was 2.3:1, lower than that 30 years before (7.7:1). 73.5% of them sought medical advice within 3 months after the onset in comparison of 63.8% 30 years before. Compared with those 30 years before the symptoms and signs were alleviated in general. The HBsAg positive rate was 81.0%, the @entity5 -Ag positive rate was 13.2%, and the alpha-fetoprotein positive rate was 75%. 1912 cases underwent pathological examination of which 91.8% were diagnosed as with @entity3 . The overall resection rate was 46,3%. Those of early, median, and late stages accounted for 29.9%, 51.5%, and 18.6% respectively in comparison with the rates of 0.4%, 47.0%, and 52.6% 30 years before. The one-year survival rate, three-year survival rate, and five-year survival rate were 66.1%, 39.7%, and 32.5% respectively for the whole group, 93.5%, 70.1%, and 59.1% for the early stage @entity0 , and 65.3%, 30.5%, and 23.5% respectively for the median stage @entity0 . The half-year survival rate and one-year survival rate of the late stage @entity0 were 52.5% and 14.7% respectively. Compared with the data 30 years before a lower percentages of the @entity0 died of @entity6 , @entity4 of upper digestive tract and @entity4 due to @entity1 , and a higher percentage of then died of asthenia universalis and other causes. CONCLUSION: In comparison with the situation 30 years ago, @entity2 can be diagnosed earlier. More @entity0 undergo resection. The prognosis of @entity2 has been improved greatly.

title: [Changes of clinical aspect of @entity2 in China during the past 30 years--control study for 3,250 cases with XXXX ].

answer: @entity2


abstract: INTRODUCTION: There are several practical problems encountered in the TLIF procedure with implantation of two @entity3 cages, such as difficulty in achieving symmetric positioning with two cages, loosening of the first cage following insertion of the second cage and higher direct costs to the @entity0 . METHOD: From January 2005 to December 2007, a total of 76 consecutive @entity0 treated with instrumented TLIF with single cage and excised local bone were enrolled in the current study. There were 45 males and 31 females aged between 31 and 75 years (mean 50.9 years). Forty-five @entity0 had @entity2 alone, 23 had associated isthmic or degenerative spondylolisthesis and 8 had recurrent disc herniations. Clinical outcomes were evaluated using the Oswestry Disability Index and a visual analog scale. Intervertebral height and fusion status were assessed on X-ray and two-dimensional computed tomography reconstruction. RESULTS: All the @entity0 followed up. The mean follow-up period was 21.8 months (range from 12 to 48 months). No nerve @entity1 occurred during operation. Postoperative ODI and VAS scores in all the @entity0 were more than the preoperative ones with significant differences. All the @entity0 had complete interbody fusion and, at the final follow-up, none had instrumentation failure. Postoperative intervertebral height in all the @entity0 was better than the preoperative ones with statistical significances. CONCLUSIONS: Instrumented TLIF with single cage is a safe and effective method for the treatment of @entity2 .

title: Instrumented transforaminal lumbar interbody fusion with single cage for the treatment of XXXX .

answer: @entity2


abstract: @entity3 in the basal ganglia were analyzed. Five @entity0 with @entity2 who were candidates for surgery had diagonal depth electrodes implanted in the basal ganglia: four of them in the putamen, and one in the pallidum and caudate. Time-frequency and power spectral analyses were used to analyze the EEG. Significant frequency components of 2-10 Hz were consistently observed in the basal ganglia. The frequency of this component slowed during @entity1 . There was a significant ictal increase in power spectral density in all frequency ranges. The changes in the basal ganglia were consistent while @entity1 activity spread over the cortex, and partially persisted after the clinical @entity1 ended. They were inconsistent in the period after @entity1 onset. @entity1 originating in the mesiotemporal structures can affect physiological rhythms in the basal ganglia. The basal ganglia did not generate epileptiform EEG activity. An inhibitory role for the basal ganglia during temporal lobe @entity1 is suggested.

title: XXXX in the @entity0 basal ganglia in @entity2 .

answer: @entity3


abstract: INTRODUCTION: Early diagnosis and treatment are keys to improve survival of @entity0 with @entity3 ( @entity3 ). The clinical characteristics of these @entity0 in Thailand were not well defined. OBJECTIVE: This study aimed to determine the clinical characteristics and outcomes of @entity0 with @entity3 in Thailand. METHODS: Medical records of @entity3 @entity0 in the past 18 years were reviewed. RESULTS: Sixty-seven @entity0 were registered. @entity2 were the most common @entity3 (52.2%), followed by combined T cell and B cell @entity2 (25.4%), other well-defined @entity2 syndromes (11.9%), and phagocytic defects (10.4%). The most common presentations of antibody deficiencies, combined T cell and B cell @entity2 , and phagocytic defects were @entity1 in the upper respiratory tract (74.3%), gastrointestinal tract (82.4%), and skin (85.7%), respectively. The highest mortality rate (52.9%) was found in severe combined @entity2 . CONCLUSION: These results provide clinical features of @entity3 in Thailand. Knowing these features will lead to prompt diagnosis and appropriate management.

title: Clinical characteristics and outcomes of primary @entity2 in Thai XXXX : an 18-year experience from a tertiary care center.

answer: @entity0


abstract: BACKGROUND: Outbreaks of @entity2 occur in several parts of India with clockwork precision closely related to changing seasons. Most recent outbreak in Puducherry occurred between October 2012 and January 2013, affected a sizable pediatric population. A prospective study was done to characterize the demographic, diagnostic and clinical profile of pediatric @entity0 in a tertiary care center in Puducherry. MATERIALS AND METHODS: Data of @entity0 serologically positive for either dengue @entity6 antigen or anti-dengue IgM antibodies were analyzed. Duration of @entity1 , platelet count, complications, risk factors, morbidity and mortality were analyzed. RESULTS: Among pediatric cases with @entity1 who were screened for @entity6 /IgM antibody during the recent outbreak, 161 (37.5%) tested positive. @entity6 was detected in 85% while 5.5% tested positive for IgM and 3% for IgG. Few (4.9%) tested positive for both @entity6 and IgM and 1.2% were positive for both @entity6 and IgG. The mean age was 6 years of which 9% were <1-year, the youngest being 1-month old @entity0 . Mean duration of @entity1 was 4 days. Vomiting was associated in 42% of cases. @entity4 (51%) and @entity3 (41%) were two major observations. Among the @entity6 positive cases, 49% had @entity4 . IgM alone and @entity6 with IgM were associated with @entity4 in 67% and 78% respectively. 14 @entity0 had complications of @entity5 , and four had @entity5 . Totally, 22 of the @entity0 had platelet transfusion. There was no mortality reported among any of these @entity0 . CONCLUSION: Combination of clinical findings and rapid @entity6 , IgM detection helped in confirming the diagnosis for appropriate management of dengue in @entity0 .

title: Dengue virus infection: Need for appropriate laboratory tests for diagnosis and management of the condition in XXXX during an outbreak.

answer: @entity0


abstract: (1) The reference prophylaxis of attacks of @entity1 is oral @entity6 , an androgenic @entity2 , which takes a few days to act. There was previously no curative treatment authorised in France. (2) @entity5 inhibitor is now licensed in France as replacement therapy for @entity0 with @entity1 due to a quantitative or qualitative deficiency in this protein. (3) The clinical evaluation file partly answers the practical questions that arise in this setting, but it does not include trials versus @entity6 . (4) In 36 @entity0 with acute attacks of @entity1 , a double-blind trial showed that symptom relief was achieved in less than half an hour in 69% of attacks treated with @entity7 , compared to only 2% of attacks treated with placebo. (5) In the prophylactic setting, a crossover trial involving six @entity0 refractory to conventional @entity4 therapy showed that injections of @entity7 every three days were more effective than a placebo in reducing the risk of attacks. (6) No major adverse effects have been attributed so far to @entity7 , but the fact that the drug is derived from @entity0 blood means that treatment carries a theoretical risk of @entity3 by conventional infectious agents (especially nude viruses) and prions. (7) In practice, for life-threatening attacks of @entity1 , @entity7 is rapidly effective in two-thirds of @entity0 and is now the reference treatment. In the absence of comparative trials, @entity6 remains the first-line prophylaxis when @entity0 are scheduled for surgery a few days later, but @entity7 is useful when @entity6 is ineffective. @entity7 is the only available prophylaxis for @entity0 undergoing emergency surgery (within a few hours).

title: XXXX : new preparation. A major advance in emergency treatment of @entity1 .

answer: @entity7


abstract: OVERVIEW: Awake fiberoptic bronchoscope (FOB) guided intubation is the gold standard of airway management in @entity0 with @entity1 . It is essential to sufficiently anesthetize the upper airway before the performance of awake FOB guided intubation in order to ensure @entity0 comfort and cooperation. This randomized controlled study was performed to compare two methods of airway anesthesia, namely ultrasonic nebulization of local anesthetic and performance of airway blocks. MATERIALS AND METHODS: A total of 50 adult @entity0 with @entity1 were randomly allocated into two groups. Group L received airway anesthesia through ultrasonic nebulization of 10 ml of 4% @entity3 and Group NB received airway blocks (bilateral superior laryngeal and transtracheal recurrent laryngeal) each with 2 ml of 2% @entity3 and viscous @entity3 gargles. FOB guided orotracheal intubation was then performed. Hemodynamic variables at baseline and during the procedure, @entity0 recall, vocal cord visibility, ease of intubation, coughing/gagging episodes, and signs of @entity3 @entity2 were noted. RESULTS: The observations did not reveal any significant differences in demographics or hemodynamic parameters at any time during the study. However, the time taken for intubation was significantly lower in Group NB as compared with the Group L. Group L had an increased number of coughing/gagging episodes as compared with Group NB. @entity4 and ease of intubation were better in @entity0 who received airway blocks and hence the amount of supplemental @entity3 used was less in this group. Overall @entity0 comfort was better in Group NB with fewer incidences of unpleasant recalls as compared with Group L. CONCLUSION: Upper airway blocks provide better quality of anesthesia than @entity3 nebulization as assessed by @entity0 recall of procedure, coughing/gagging episodes, ease of intubation, vocal cord visibility, and time taken to intubate.

title: Topical airway anesthesia for awake fiberoptic intubation: Comparison between airway nerve blocks and nebulized XXXX by ultrasonic nebulizer.

answer: @entity3


abstract: BACKGROUND: One-stage anterior release and posterior reduction is one of the most effective methods for irreducible @entity3 . However, the criteria of appropriate tissue release for successful posterior reduction is yet to be confirmed. Hence, an assistant technique using the transoral approach to verify satisfactory release is required. To evaluate the efficacy of the modified technique of transoral release for irreducible @entity3 (IAAD) with @entity0 underwent one-stage anterior release and posterior reduction. METHODS: Between January 2009 and June 2014, 23 consecutive @entity0 diagnosed with IAAD free from bony union between the C1-C2 facet joints on reconstructive computed tomography scan underwent one-stage anterior release and posterior reduction after no response to 2 weeks of skull traction. During transoral release, an elevator was used as a lever repeatedly to confirm a 3-5  mm bilateral joint space between the lateral masses of the atlas and @entity2 . The release was accomplished since a 3-5  mm joint space was achieved. After anterior release, posterior reduction and instrumented fusion were subsequently performed. RESULTS: All @entity0 were observed for an average of 18 (range 6-50) months. Nineteen of 23 @entity0 achieved complete reduction while four had an incomplete reduction. Significant differences in pre- and postoperative JOA scores and cervicomedullary angle (CMA) were found. Twenty-one @entity0 presenting with @entity1 had a JOA score of 12.9 at final follow-up, improved from 7.8 before surgery. The mean CMA improved to 143.5   postoperatively from 101.8   preoperatively. Bony fusion was confirmed in all cases under radiologic assessment during follow-up; there were no instrument failures. CONCLUSION: The modified technique of transoral release provides appropriate criteria for anterior release, to achieve good posterior reduction without excessive tissue release or intraspinal manipulation, proving its value as an assistant technique in one-stage anterior release and posterior reduction for IAAD.

title: Modified technique of transoral release in one-stage anterior release and posterior reduction for irreducible XXXX .

answer: @entity3


abstract: BACKGROUND: The molecular pathogenesis of @entity7 of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine @entity2 or arise due to the @entity7 (WDECs). METHODS: Ten gastric and 9 colorectal PDECs, 9 gastric WDECs, and 12 @entity0 ( @entity1 ) were analyzed for loss of heterozygosity (LOH) at 11q13 ( @entity9 ), 17p13.1 ( @entity3 ), 3p14.2 ( @entity10 ), 3p21.3 ( @entity8 ), and 18q23 (DCC/ @entity5 / @entity6 ), and for immunohistochemical expression of @entity3 , @entity10 , Rb, and @entity4 . RESULTS: PDECs exhibited high fractional allelic loss (FAL; 0.49), with frequent (> 40%) alterations in @entity3 , Rb, @entity9 , @entity10 , and 18q. No significant differences were found between gastric and colorectal PDECs. Gastric WDECs also exhibited high FAL (0.44), with frequent alterations in Rb and/or @entity4 , @entity9 , and 3p21. @entity1 exhibited a low level of FAL (0.23), with frequent (> 50%) @entity4 and @entity3 alterations. When gastric PDECs and WDECs were compared, substantial similarities were found with respect to FAL (0.42 vs. 0.44) and with respect to individual gene alterations, except in @entity3 , which was consistently altered only in PDECs. @entity1 , which were characterized by a lower FAL (0.56 vs. 0.23) and which lacked alterations in both 3p and Rb, were found to be significantly different from colorectal PDECs. CONCLUSIONS: GI PDECs demonstrated a high level of chromosomal instability; consistent inactivation of both the @entity3 and @entity4 /Rb pathways; and frequent LOH at 3p (possibly involving @entity10 ), the @entity9 locus, and 18q. The profile of genetic alterations in PDECs was more consistent with the profile in WDECs than with the profile in @entity1 .

title: Genetic alterations in XXXX of the gastrointestinal tract.

answer: @entity7


abstract: OBJECTIVE: To examine the use of @entity3 ( @entity4 ) in @entity2 ( @entity2 ) @entity0 during the perioperative period. METHODS: Systematic review of studies retrieved by a sensitive search strategy in Medline (1961-July 2007), Embase (1961-July 2007), Cochrane Library (up to July 2007), and from the abstracts of the ACR (2005, 2006) and EULAR (2005-2007) annual scientific meetings. SELECTION CRITERIA: (population) studies had to include @entity0 with @entity2 undergoing surgery; (intervention and control) studies had to test continuing @entity4 versus stopping @entity4 ; and (outcomes), studies had to report complications within a year after the surgery including @entity1 , wound morbidity, surgery complications, and @entity2 flares. Only randomized controlled trials (RCT) or high quality cohort studies with a control group were included. RESULTS: @entity0 from the four included studies were mostly @entity0 with mean ages around 60. All of them underwent elective orthopaedic surgery and were taking @entity4 doses mainly from 5 mg/week to 10 mg/week. By order of level of evidence, we found two RCTs, in which continuing on @entity4 was not associated with increasing risk of surgery complications, but it was statistically associated with less @entity2 flares. In a prospective cohort study, four @entity1 were observed in the @entity4 group while none were observed in the control group. No disease flare was reported in any group. A retrospective study showed that @entity0 on @entity4 reported fewer cases of wound morbitity (p=0.038), @entity2 flares (p=0.050), and no differences related to @entity1 compared to those who stopped @entity4 . CONCLUSIONS: Continuing with low doses of @entity4 seems to be a safe option during the perioperative period in @entity2 @entity0 without relevant comorbidities and/or risk factors of @entity1 , undergoing elective orthopaedic surgery, while maintaining disease control.

title: A systematic review on the optimum management of the use of @entity3 in XXXX @entity0 in the perioperative period to minimize perioperative morbidity and maintain disease control.

answer: @entity2


abstract: BACKGROUND: This study examined whether @entity1 (< 36.0  C) incidence among @entity2 @entity0 varied over time, the determinants of change, and the associated risk for ICU mortality. METHODS: Interrupted time series analysis among adults admitted to ICUs in Calgary, Canada over 8.5 years. Changes in the incidence of @entity1 within the first 24 hours of ICU admission were modelled using segmented regression. RESULTS: Among 15,291 first admissions to ICU, @entity1 incidence decreased from 29% to 21% during the study period. Implementation of a new temporal artery thermometer (TAT) was associated with the majority of the decrease in incidence (10%; 95% CI 7.1-13%; P < .0001). However, subgroup analysis revealed important differences between medical and surgical @entity0 . @entity1 incidence decreased among surgical @entity0 before TAT implementation (0.4% per quarter, 95% CI 0.1-0.7%, P = .009), but not after, whereas in medical @entity0 , the incidence increased after (1.0% per quarter, 95% CI 0.6-1.4%, P < .0001) but not before TAT implementation. Segmented logistic regression suggested that increases in the proportion of @entity0 with non-traumatic neurologic admission diagnoses were associated with @entity1 incidence among medical @entity0 , whereas there was no measurable clinical factor associated with the observed time trends among surgical @entity0 . @entity1 at ICU admission was independently associated with ICU mortality in medical and surgical @entity0 throughout the entire study. CONCLUSION: The incidence of @entity1 at ICU admission was dependent on medical versus surgical status, and the method of non-invasive temperature measurement, but was persistently associated with ICU mortality.

title: XXXX in Adult ICUs: Changing Incidence But Persistent Risk Factor for Mortality.

answer: @entity1


abstract: @entity2 ( @entity2 ) of the salivary gland has diverse biological behavior in spite of its being a @entity0 . So the nuclear DNA content of 36 PAs was measured by flow cytometry to determine the relationship between proliferative activity and histopathological variable. DNA histograms were evaluated according to the rate of S and G2+ M phase cells (S + G2M%). We assumed that the DNA histogram measured algebraically, S + G2 M% < or = 0%, is the near diploid pattern and calculated its ratio to the near diploid pattern. A statistically significant difference between @entity2 and normal salivary gland was found by the ratio to the near diploid pattern (P < 0.05), which confirmed the usefulness of the ratio to the near diploid pattern for measuring low proliferative activity. The @entity0 were divided into 3 groups: epitheloid type, intermediate type and myxochondroid type. In the 3 groups no differences were found by S + G2M% and the ratio to the near diploid pattern. The areas of the @entity0 were divided into 5 groups according to the ratio in the epitheloid region and the myxochondroid region. In the 5 groups, the area which consists partly of epitheloid components and mostly of myxochondroid components had the lowest ratio to the near diploid pattern and the highest S + G2M%, and the area which consists of only myxochondroid components had the highest ratio to the near diploid pattern and the lowest S + G2M%. Between only these two areas a statistically significant difference was found by the ratio to the near diploid pattern (P < 0.05). We considered that the area which consists partly of epitheloid components, and mostly of myxochondroid components has the highest proliferative activity in @entity2 . Neither @entity1 cells were found in any @entity0 , but the S + G2M% is more than 20% in 4 @entity0 . None of these high S + G2M% @entity0 except one recurrent @entity0 had clinical and histopathological features. A differences between PAs of the parotid glands and PAs of the submandibular glands was not found in S + G2M%.

title: [Flow cytometric analysis of proliferative activity of XXXX of salivary gland].

answer: @entity2


abstract: BACKGROUND: Characterization of the prognostic variables for persistent @entity1 (PNP) remains incomplete despite multiple articles addressing this topic. To provide more insight into the recovery and prognosis of @entity1 , high-quality data are required that provide information about the predictors that contribute to the development of PNP. OBJECTIVE: To determine the methodological quality of studies about predictors for PNP and to summarize findings of predictors found in high-quality studies. STUDY DESIGN: A systematic review. SETTING: VU University Medical Center, Amsterdam, The Netherlands. METHODS: Studies were identified by searching the electronic databases PubMed, Embase, and Cochrane Library. Methodological quality of each article was independently assessed by 2 reviewers. RESULTS: Forty-six relevant studies were identified, classified into 4 different @entity1 ( @entity1 )-syndromes: @entity9 (n = 35), @entity3 and sciatica (n = 3), postsurgical @entity3 (n = 6), and other types of @entity1 (n = 2). Seven studies were of high quality. The 3 high-quality studies found for PHN reported male gender, older age, smoking, @entity2 at the site of lesion, missed antiviral prescriptions, higher @entity8 severity, higher rash severity, more neuropathic characteristics, @entity6 , and a lower health status as predictors for PNP. For persistence of @entity3 one high-quality study reported negative outcome expectancies, @entity3 -related fear of movement, and passive @entity3 coping as predictors for PNP. @entity4 , @entity8 , @entity0 surgery, higher body mass index, area of secondary @entity7 , neuropathic characteristics, @entity5 , and @entity10 were found to be predictive for postsurgical @entity3 in 3 high-quality studies. LIMITATIONS: Some publications may have been missed during literature search. The low-quality of the studies could be the result of an incomplete description of their methods. CONCLUSIONS: High-quality studies mainly assessed factors related to disease functions and structures. Due to shortcomings in methodological quality and limited areas of predictor selection, there is a need for high-quality studies focusing on predictor measurement, statistical analysis and the use of a standardized set of predictors.

title: Predictors of Persistent XXXX - A Systematic Review.

answer: @entity1


abstract: BACKGROUND: @entity4 ( @entity4 ) and rhizotomy are all selected for treating @entity1 ( @entity1 ). Nonetheless, controversies still exist about their curative effect on @entity1 . Here we evaluate the effectiveness of @entity4 together with rhizotomy of the glossopharyngeal nerve for the treatment of @entity1 . METHODS: This study was carried out on 21 @entity0 who were diagnosed with @entity1 between the years 2005 and 2010. @entity0 underwent @entity4 and glossopharyngeal rhizotomy through a retromastoid keyhole approach. Surgical technique, operation results and complications were our particular concern. RESULTS: Eighteen (85.7%) of 21 @entity0 experienced immediate and complete relief of @entity2 after surgery. In the remaining 3 @entity0 (14.3%), the @entity2 faded away within the following week. No @entity0 complained of @entity5 or @entity3 . All 21 @entity0 reported no change in their outcome at follow-up. CONCLUSIONS: Intracranial vagoglossopharyngeal nerve @entity4 with glossopharyngeal rhizotomy is an effective and safe procedure to treat @entity1 .

title: XXXX treated by microvascular decompression and glossopharyngeal rhizotomy: clinical results of 21 cases.

answer: @entity1


abstract: The specificity of a previously developed 57-criteria/32-point QRS scoring system for estimating @entity1 ( @entity1 ) size is evaluated in an extensive control population and the method of application of this system for determining a QRS score from a standard 12-lead electrocardiogram is described. Points are accumulated from Q- and R-wave durations, R- and S-wave amplitudes, R/Q- or R/S-amplitude ratios and the presence of R-wave notching, with each point representing approximately 3% of the left ventricle. The subjects were selected because of the minimal likelihood of their having had @entity1 or other sources of QRS modification. There were 500 consecutively selected normal Caucasian subjects, aged 20 to 69 years, with 50 @entity0 and 50 @entity0 in each of the 5 decades. Specificity for the 57 individual criteria ranged from 89 to 100%. Fifty-one criteria met the required standard of at least 95% specificity; of the 6 that failed, 3 were successfully modified to achieve this standard and 3 were eliminated. In the resultant 54-criteria/32-point complete system, the total population, as well as both @entity0 and @entity0 , required more than 3 points to attain at least 95% specificity. Subjects in each of the 5 decades met the specificity standard either at or below the level of more than 3 points. The point score at which 95% or greater specificity was attained for the 10 age/sex subsets varied.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Evaluation of a QRS scoring system for estimating XXXX size. V. Specificity and method of application of the complete system.

answer: @entity1


abstract: A new strategy for the characterization of Coomassie Brilliant Blue stained @entity1 -PAGE separated proteins by UV-MALDI- @entity0 is reported. The proteins are extracted directly from the @entity5 gel by treatment with an organic solvent mixture consisting of @entity6 , @entity3 , @entity7 and water in an ultrasonic bath. A fraction of the supernatant is then mixed directly with the matrix solution and measured by MALDI- @entity0 . High quality spectra could be obtained from gels which were loaded with 6 pmol of myoglobin. Compared to other methods based on electroblotting or electroelution this method is much simpler and less time consuming. The sensitivity is higher than or comparable to the Coomassie Blue staining procedure for proteins up to about 25 kDa. Another advantage is that mass shifts due to charging effects of the membranes, which are common if membranes are mounted directly on the sample target, can be avoided. However, all proteins studied showed slightly higher masses than expected which reduces mass accuracy to 0.2-0.3%. This is presumably partly due to formylation of @entity2 or @entity4 residues during incubation in formic acid. Gel electrophoresis induced modifications can contribute as well. The possibility of further characterizing the remaining part of the supernatant after extraction by means of proteolytic digestion is also demonstrated. The knowledge of both molecular weight of the whole protein and of the proteolytic fragments increases specificity for protein identification by searching in sequence databases.

title: Matrix-assisted laser desorption/ionization mass spectrometry of proteins extracted directly from @entity1 - XXXX gels.

answer: @entity5


abstract: BACKGROUND: @entity3 associated with @entity6 induce @entity5 in the electrocardiogram. Electrocardiographic evidence of @entity2 may appear if the @entity1 is electrically active. To our knowledge, electrocardiographic evidence of @entity2 has been reported only in association with @entity4 . Follow-up studies of changes in electrocardiographic findings are also lacking. METHODS: We studied 21 consecutive @entity0 with @entity3 associated with @entity6 , 10 males and 11 females, aged from the date of birth to 9 years at diagnosis. The mean period of follow-up was 53 months. None of the @entity0 developed @entity4 . We evaluated the electrocardiographic changes during the follow-up, and their association with echocardiographic findings. RESULTS: Of the 21 @entity0 , 12 showed one or more abnormalities on the electrocardiogram at presentation, with five demonstrating right or @entity8 . In all of these five cases, the @entity1 were mainly located in the respective ventricular cavity. In one @entity0 with a @entity1 expanding exteriorly, there was marked @entity8 on the electrocardiogram. Followup studies showed spontaneous regression of the @entity1 in 12 of 19 @entity0 , with abnormalities still present in only 7 @entity0 . A gradual disappearance of @entity8 as seen on the electrocardiogram was noted in the @entity0 with marked @entity8 at presentation in parallel with regression of the @entity1 . CONCLUSIONS: The presence of @entity3 in @entity0 with @entity6 might explain the @entity2 seen on the electrocardiogram through its electrically active tissue without ventricular pressure overload or ventricular enlargement, although @entity7 might affect the amplitude of the QRS complex. Even in cases with large @entity1 , nonetheless, the electric potential might- not alter the surface electrocardiogram if the direction of growth of the @entity1 is towards the ventricular cavity. In many cases, @entity5 tend to disappear, concomitant with regression of the @entity1 .

title: Electrocardiographic changes in @entity0 with @entity3 associated with XXXX .

answer: @entity6


abstract: Serous @entity4 is an aggressive @entity1 . Point mutations in the @entity2 suppressor gene might explain in part the rapid growth of this @entity1 and its unfavorable outcome. The aims of this study were to evaluate the behavior of serous @entity4 developing in @entity5 and to assess the @entity2 protein overexpression. @entity0 included in this study were treated in our institution between 1982 and 2003. All clinical and pathological materials were examined. A @entity2 protein immunohistochemical analysis was performed on paraffin-embedded tissues. Thirteen serous @entity4 arising from benign polyps of the endometrium were identified. The @entity0 ' age averaged 73 years. All @entity0 were treated surgically. After an average follow-up of 22 months, 54% of the @entity0 were dead or alive with disease. Of 10 serous @entity4 , 8 (80%) for which @entity3 blocks were available overexpressed the @entity2 protein. A serous @entity4 arising from benign polyps of the endometrium remains a malignant @entity1 with an unfavorable outcome even if the @entity1 is limited to the polyp. The high rate of protein @entity2 overexpression suggests that a @entity2 gene mutation occurs early in the disease and might explain the rapid growth of the @entity1 .

title: Serous @entity4 of the endometrium arising from XXXX : a clinical, histological, and immunohistochemical study of 13 cases.

answer: @entity5


abstract: OBJECTIVE: The present study shows the results of a double-blind sham-controlled pilot trial to test whether measurable stimulus-specific functional connectivity changes exist after Automatic Mechanical Peripheral Stimulation (AMPS) in @entity0 with @entity2 . METHODS: Eleven @entity0 (6 @entity0 and 5 @entity0 ) with @entity2 underwent brain fMRI immediately before and after sham or effective AMPS. Resting state Functional Connectivity (RSFC) was assessed using the seed-ROI based analysis. Seed ROIs were positioned on basal ganglia, on primary sensory-motor cortices, on the supplementary motor areas and on the cerebellum. Individual differences for pre- and post-effective AMPS and pre- and post-sham condition were obtained and first entered in respective one-sample t-test analyses, to evaluate the mean effect of condition. RESULTS: Effective AMPS, but not sham stimulation, induced increase of RSFC of the sensory motor cortex, nucleus striatum and cerebellum. Secondly, individual differences for both conditions were entered into paired group t-test analysis to rule out sub-threshold effects of sham stimulation, which showed stronger connectivity of the striatum nucleus with the right lateral occipital cortex and the cuneal cortex (max Z score 3.12) and with the right anterior temporal lobe (max Z score 3.42) and of the cerebellum with the right lateral occipital cortex and the @entity1 (max Z score 3.79). CONCLUSIONS: Our results suggest that effective AMPS acutely increases RSFC of brain regions involved in visuo-spatial and sensory-motor integration. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that automatic mechanical peripheral stimulation is effective in modulating brain functional connectivity of @entity0 with @entity2 at rest. TRIAL REGISTRATION: Clinical Trials.gov NCT01815281.

title: Acute Modulation of Brain Connectivity in XXXX after Automatic Mechanical Peripheral Stimulation: A Pilot Study.

answer: @entity2


abstract: A 44-year-old @entity0 presented to her GP with excessive tiredness. She had positive thyroid microsomal and thyroglobulin autoantibodies and was found to have an elevated serum thyroid-stimulating hormone (TSH) concentration of 8.37 (normal = 0.15-3.5)mU/L and a low normal total @entity3 (T4) of 86 (reference range 60-145)nmol/L. She was rendered symptom free on a dose of 150 microg of @entity3 per day. However, her TSH failed to return to normal, and following a further increase in her @entity3 dose she was referred to the endocrine clinic for further assessment. Her TSH at this stage was 14mU/L, free T4 (fT4) 28 (normal = 10-27)pmol/L and free T3 (fF3) 10 (normal = 4.3-7.6)pmol/L. She denied any problems with adherence to her medication. Her serum prolactin was elevated at 861 (normal = 60-390)mU/L. @entity1 was suspected and an MRI scan showed a macroadenoma of the right lobe of the pituitary, extending into the suprasellar cistern. The @entity1 was resected trans-sphenoidally. Electron microscopy showed a dual population of neoplastic cells compatible with a thyrotroph cell and prolactin-secreting @entity2 . Immunocytochemistry and cell culture studies confirmed the secretion of TSH, prolactin and alpha-subunit. Postoperative combined anterior pituitary function tests did not demonstrate any deficiency of anterior pituitary hormones. A repeat MRI scan showed no significant @entity1 ; however, her serum TSH and prolactin levels remained high and she was given a course of pituitary irradiation. This case illustrates the difficulty of diagnosing a TSHoma when it coexists with @entity4 . We believe the combination of pathologies reported here is unique.

title: XXXX coexisting with a pituitary adenoma secreting thyroid-stimulating hormone, prolactin and alpha-subunit.

answer: @entity4


abstract: Strongyloides venezuelensis (SVZ) @entity2 was chronologically monitored in 85 @entity0 (SDR), which were orally inoculated with approximately 1,000 infective larvae. In order to describe the characteristics of migrating larvae ( @entity5 ) in various visceral organs (the liver, lung, cardiac blood, and small intestine), 5 SDR were sacrificed at 20 min, 45 min, 1 hr, 2 hr, 3 hr, 4 hr, 8 hr, 12 hr, 16 hr, 48 hr, 72 hr, 96 hr, 120 hr, 144 hr, 168 hr and 192 hr post inoculation (PI). @entity5 were recovered from the liver and blood 20 and 45 min PI and measured 788 +/- 26 microm and 846 +/- 40 microm in length, respectively. @entity5 were first observed in the lung tissue 45 min PI and measured 925 +/- 38 microm on the average. In the @entity3 , @entity5 measuring 849 +/- 75 microm appeared 3 to 96 hrs PI. @entity4 ( @entity4 ) measuring 1,926 +/- 521 microm to 2,956 +/- 159 microm in length were observed in the small intestine from 120 hr PI. The worms appeared to mature more than 168 hr PI and attained the average maximum length of 2,420 +/- 532 microm. At 3 hr PI focal @entity1 were evidently observed in the liver and lung, together with eosinophilic infiltration in the stomach, liver, and lung. The parasites were histologically detectable in the lung tissues but were very difficult to find in the liver and the epithelial layer of small intestine. These data demonstrate that SVZ parasites take 20 min to reach the liver via the stomach and only three hours to reach the @entity3 through the same route. The development from eggs to adults takes 168 hr in the SDR model.

title: Migration of Strongyloides venezuelensis in XXXX after oral inoculation of free-living infective larvae.

answer: @entity0


abstract: Several experimental studies have suggested that the vasodilatory effects of @entity1 channel blockers (CCBs) are due in part to an endothelium-dependent mechanism. However, it remains unknown whether CCBs directly augment liberation of endothelium-derived dilator substances such as @entity3 (NO) in the @entity0 vasculature. The aim of this study was to examine whether CCBs of several kinds directly increase the bioavailability of NO in forearm resistance vessels. Twenty-four healthy @entity0 (mean age 30 +/- 2 years) were randomly assigned to three study groups (n = 8 in each), and each group was assigned one of three first-generation CCBs ( @entity2 , @entity6 , @entity7 ). Subdepressor doses of CCBs [4, 8, 16, 24, and 36 ( @entity7 only) nmol/min; for 2 min in each dose] were infused intra-arterially, and forearm blood flow (FBF) was determined plethysmographically. After control FBF responses to CCBs had been measured, a NO synthase inhibitor (N(G)-monomethyl-L-arginine: @entity8 ) was infused intra-arterially, and the FBF response to CCBs was again determined. Further, as a positive control for NO stimulation, @entity4 ( @entity5 ) was also examined before and after @entity8 in each group. Systemic blood pressure and heart rate did not change significantly during the study protocol. The FBF responses to these CCBs did not differ before and after NO synthase inhibition by @entity8 (FBF at maximum doses: @entity2 , 8.0 +/- 0.8 vs. 7.3 +/- 0.7; @entity6 , 7.3 +/- 1.5 vs. 6.5 +/- 1.3; @entity7 , 5.7 +/- 0.7 vs. 4.2 +/- 0.7 ml/min per 100 ml: all not significant), although FBF responses to @entity5 were significantly reduced by @entity8 . In conclusion, direct NO liberation does not make a significant contribution to the vasodilation associated with first-generation CCBs in healthy @entity0 resistance vessels.

title: @entity3 plays an insignificant role in direct vasodilator effects of XXXX channel blockers in healthy @entity0 .

answer: @entity1


abstract: BACKGROUND: Polyomavirus associated @entity1 (PVAN) is a significant cause of early allograft loss and the course is difficult to predict. The aim of this study is to identify factors influencing outcome for PVAN. METHODS: Between 2006 and 2014, we diagnosed PVAN in 48 (7.8%) of 615 @entity0 monitored for @entity4 every 1-4 weeks after modification of maintenance immunosuppression. Logistic or Cox regression analysis were performed to determine which risk factors independently affected clinical outcome and graft loss respectively. RESULTS: After 32.1  26.4 months follow-up, the frequencies of any graft functional decline at 1 year post-diagnosis, graft loss and any graft functional decline at the last available follow-up were 27.1% (13/48), 25.0% (12/48), and 33.3% (16/48), respectively. The 1, 3, 5 year graft survival rates were 100%, 80.5% and 69.1%, respectively. The mean level of serum @entity3 at 1 year post-diagnosis and long-term graft survival rates were the worst in class C (p<0.05). Thirty-eight of 46 (82.6%) @entity4 DNAuria @entity0 reduced viral load by 90% with a median time of 2.75 months (range, 0.25-34.0 months) and showed better graft survival rates than the 8 @entity0 (17.4%) without viral load reduction (p<0.001). Multivariate logistic regression analysis showed that extensive @entity2 (OR 20.2, p = 0.042) and delayed fall in urinary viral load (>2.75 months for >90% decrease) in urine (OR 16.7, p = 0.055) correlated with worse @entity3 at 1 year post-diagnosis. Multivariate Cox regression analysis showed that extensive @entity2 (HR 46988, p = 0.032) at diagnosis, and high PVAN stage (HR 162.2, p = 0.021) were associated with worse long-term graft survival rates. CONCLUSIONS: The extent of @entity2 influences short and long-term graft outcomes in @entity0 with PVAN. The degree of PVAN, rate of reduction in viral load, and viral clearance also can be used as prognostic markers in PVAN.

title: Factors Influencing Graft Outcomes Following Diagnosis of XXXX after Renal Transplantation.

answer: @entity1