abstract: BACKGROUND: We previously showed that mitochondrial respiratory function is abnormal in @entity1 with chronic @entity2 ( @entity2 ). Mitochondrial permeability transition pores ( @entity4 ) can affect mitochondrial inner membrane potential (DeltaPsim) and mitochondrial function in normal cardiomyocytes. The potential impact of @entity4 on DeltaPsim and mitochondrial respiratory function in @entity2 has not yet been determined. We tested the hypothesis that @entity0 , a potent blocker of the @entity4 , can improve mitochondrial function in @entity2 . METHODS: Cardiomyocytes were isolated from the left ventricular myocardium of 7 @entity1 with @entity2 produced by intracoronary microembolizations and from 7 normal @entity1 . Cardiomyocytes were treated for 24 hours with @entity0 . DeltaPsim, cytochrome c oxidase protein expression, mitochondrial cytochrome c oxidase-dependent respiration (CDOR) and @entity3 synthesis were measured. RESULTS: DeltaPsim, protein expression of cytochrome c oxidase, CDOR and the rate of @entity3 synthesis were decreased in @entity2 compared to normal controls. Inhibition of @entity4 in failing cardiomyocytes with low dose of @entity0 (0.2 microM) increased DeltaPsim, preserved expression of cytochrome c oxidase, improved CDOR and the rate of @entity3 synthesis. CONCLUSION: @entity4 opening contributes to the loss of mitochondrial function observed in the failing heart. Inhibition of @entity4 opening represents a potential therapeutic target for the treatment of @entity2 .

title: Inhibition of mitochondrial permeability transition pores by @entity0 improves cytochrome C oxidase function and increases rate of XXXX synthesis in failing cardiomyocytes.

answer: @entity3


abstract: Impairment of @entity1 (NO) production, @entity4 receptor (RyR) @entity0 channel function and adrenoceptor activation have been found to prevent the formation of the long-term memory stage in young chicks trained on a single-trial discrimination avoidance task. The current study investigated whether these three activities were linked, and if so, the sequence of activation. Young chicks were trained using either a strongly or weakly reinforced variant of the single-trial discrimination avoidance task, yielding either a persistent or labile memory trace, respectively. Following strongly reinforced training, @entity3 induced by a RyR inhibitor was prevented by a NO donor or @entity2 (NA). A RyR agonist also prevented @entity3 induced by either NO synthase or b1+2-adrenoceptor inhibition. These findings were interpreted to reflect the capacity of NO, RyR-dependent @entity0 release and NA to modulate memory by preventing @entity3 . A second set of studies used weakly reinforced training. Although the administration of a RyR agonist promoted long-term memory formation, this facilitation was compromised in the presence of a b1+2-adrenoceptor antagonist, but not a NO synthase inhibitor. Similarly, the inhibition of RyRs interfered with the facilitation of retention induced by a NO donor, but not NA. These differential findings with weakly reinforced training suggest that NO facilitates memory formation through mechanisms involving RyR-dependent @entity0 release. The findings also indicate that RyRs may promote memory formation through noradrenergic activation of b2-adrenoceptors. This study demonstrates an intricate role for RyRs underlying memory formation.

title: Pharmacobehavioural evidence for XXXX and @entity2 interactions with @entity4 receptors during memory formation in the young chick.

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to evaluate the utility of the @entity7 beam coagulator (ABC) in achieving optimal (< or =1 cm) disease status and facilitating the conversion of optimal but visible disease (0.1-1.0 cm) to microscopic @entity4 (complete cytoreduction) among @entity0 with advanced @entity3 . METHODS: All @entity0 undergoing their primary attempt at surgical cytoreduction for Stage IIIB-IV @entity3 between October 1, 1997 and June 30, 2000 were identified from the @entity1 registry database. Data were abstracted retrospectively and included: the size/location of precytoreduction disease, surgical procedures performed, the anatomic regions in which the ABC was used for cytoreduction, the size/location of @entity2 , and the date of last follow-up and disease status. Survival curves were generated using the Kaplan-Meier method, and statistical comparisons were performed using the chi(2) test, Fisher's exact test, log rank test, and multivariate logistic regression. RESULTS: Forty-five @entity0 were identified (FIGO Stage IIIB = 8, Stage IIIC = 29, Stage IV = 8). Overall, optimal cytoreduction was achieved in 84.4% of @entity0 ; 60.0% had only microscopic residual and 24.4% had @entity4 0.1-1.0 cm. The ABC was used to facilitate cytoreduction in 31 @entity0 . Optimal disease status was achieved in 93.6% of cases in which the ABC was used compared with 64.3% for non-ABC cases (P < 0.023). ABC use was also associated with a higher rate of complete cytoreduction (74.2%) compared with non-ABC cases (28.6%, P < 0.004). Among @entity0 left with @entity4 (< or =1 cm), conversion to only microscopic residual was achieved in 79.3% of cases using the ABC and 44.4% of cases without ABC use (P < 0.044). The ABC was associated with a statistically significantly higher rate of complete cytoreduction for disease located in the lesser sac/gastrocolic ligament (90.9% vs 14.3%), abdominal peritoneum (95.5% vs 50.0%), bowel mesentery (80.0% vs 0), and pelvis (89.3% vs 50.0%). Multivariate analysis revealed that use of the ABC (P = 0.006) and disease in three or fewer anatomic regions (P = 0.014) were independent predictors of a microscopic residual surgical outcome. Complete cytoreduction was associated with a significant advantage in median progression-free survival (22.2 months) compared with @entity0 with optimal but visible (0.1-1.0 cm) @entity4 (12.3 months) and those with suboptimal (>1.0 cm) @entity4 (6.3 months, P < 0.001). Among ABC cases, the mean estimated @entity5 was 527 ml, and major @entity6 occurred in 9.7% of @entity0 . CONCLUSIONS: The ABC is a useful adjunct to conventional @entity1 reductive techniques and appears to significantly increase the feasibility of achieving both @entity4 status and complete cytoreduction of all visible @entity1 in @entity0 with macroscopic metastatic @entity3 .

title: Complete surgical cytoreduction of advanced XXXX using the @entity7 beam coagulator.

answer: @entity3


abstract: OBJECTIVES: The main purpose of this study was to determine whether any clinical or demographic characteristics could identify adult female @entity0 presenting to the @entity3 ( @entity3 ) with a history of @entity5 . A second objective was to describe the frequency, types, and severity of this abuse. METHODS: This study was a crosssectional survey of 611 @entity0 conducted in an academically-affiliated, urban @entity3 . @entity5 was described as "recent" (within the preceding 12 months) or "lifetime" (recent or past). This included emotional, physical, and @entity4 . RESULTS: Recent (7.9%, n = 48) and lifetime (38%, n = 232) @entity5 was reported. For recently abused @entity0 , violence had been severe (87.5%, n = 42) and was associated with 1) @entity1 (OR 5.4, 95% CI = 2.6 to 11.6), 2) obstetrical and gynecological syndromes (OR 5.6, 95% CI = 2.4 to 13.2), and 3) @entity2 symptoms and substance use (OR 7.3, 95% CI = 2.4 to 22.0). The sensitivities and positive predictive values of these risk factors individually (<27.1% and <25.0%, respectively) and in aggregate (56.3% and 20.9%, respectively) were low. These indicators predicted only 27 (56.3%) of recently abused @entity0 . Lifetime domestic violence was more likely in homeless @entity0 (OR 5.8, 95% CI = 2.2 to 15.0), although less likely in immigrants (OR 0.4, 95% CI = 0.3 to 0.7). CONCLUSIONS: Clinical presentations and demographic characteristics of @entity0 presenting to the @entity3 may not be sensitive or predictive indicators of @entity5 . In the absence of typical clinical or demographic findings, asking all @entity0 in the @entity3 about @entity5 remains a necessary priority.

title: XXXX in the @entity3 : can a risk profile be defined?

answer: @entity5


abstract: Urine drug testing (UDT) is an emerging standard of care in the evaluation and treatment of chronic non- @entity1 @entity2 @entity0 with opioid analgesics. UDT may be used both to verify adherence with the opioid analgesic regimen and to monitor abstinence from non-prescribed or illicit controlled substances. In the former scenario, it is vital to determine whether the drug is present in the urine, even at low concentrations, because failure to detect the drug may lead to accusations of @entity5 or diversion. Opiate immunoassays typically are developed to detect @entity3 and are most sensitive to @entity3 and @entity6 . Although many opiate immunoassays also detect @entity4 (HC) and/or @entity7 (HM), sensitivities for these analytes are often much lower, increasing the possibility of negative screening results when the drug is present in the urine. We selected 112 urine specimens from @entity0 who had been prescribed HC or @entity7 but were presumptive negative by the Roche Online DAT Opiate II    urine drug screening assay, which is calibrated to 300 ng/mL @entity3 . Using a GC/MS confirmatory method with a detection limit of 50 ng/mL both for HC and for HM, one or both of these opiates were detected in 81 (72.3%) of the urine specimens. Examination of the raw data from these presumptive negative opiate screens revealed that, in many cases, the turbidity signal was greater than the signal obtained for the negative control, but less than the signal for the 300 ng/mL ( @entity3 ) threshold calibrator. A receiver operating characteristic curve generated for the reciprocal of the ratio of turbidity measurements in the @entity0 specimens and negative (drug-free) controls, against the presence or absence of HC and/or HM by confirmatory analyses, produced an area under the curve of 0.910. We conclude that this opiate immunoassay has sufficient sensitivity to detect HC and/or HM in some urine specimens that screen presumptive negative for these commonly prescribed opiates at the established threshold.

title: Sensitivity of an Opiate Immunoassay for Detecting XXXX and @entity7 in Urine from a Clinical Population: Analysis of Subthreshold Results.

answer: @entity4


abstract: UNASSIGNED: @entity14 is an intermediate in the manufacture of @entity12 dyes. In a National Toxicology Program stop-exposure study, @entity14 induced @entity6 , @entity5 , and @entity7 in the urinary bladder of Fischer 344/ @entity2 . @entity14 was investigated since occupational or environmental exposure to @entity9 and @entity12 dyes is a risk factor for @entity3 in @entity0 . The current study describes the morphology of @entity3 seen in @entity2 with respect to those observed in @entity0 . This study also evaluated immunohistochemical expression of the cell cycle-related proteins @entity11 and @entity10 and the differentiation markers @entity13 and uroplakin III in @entity8 (n = 11) and neoplastic (n = 6 @entity5 , n = 11 @entity4 ) lesions of the urinary bladder epithelium from @entity2 treated with @entity14 and in normal (n = 6) urinary bladders from untreated @entity2 . The @entity1 observed were more similar to the papillary type rather than the muscle-invasive type of @entity3 in @entity0 . The preneoplastic and neoplastic lesions observed suggest progression from @entity6 to @entity5 to @entity7 . With @entity1 ( @entity6 to @entity4 ), @entity11 immunoreactivity progressively increased in intensity, percentage of cells staining, and distribution. Overexpression of @entity10 was not found. @entity13 staining decreased in superficial cells, while uroplakin III staining increased in intermediate and basal cells with progression from @entity6 to @entity4 . The results are consistent with increased cell cycle dysregulation or proliferation ( @entity11 ), decreased differentiation ( @entity13 ), and abnormal differentiation (uroplakin III) as lesions progress toward @entity1 .

title: Immunohistochemical Expression of XXXX , @entity13 , and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by @entity14 in Fischer 344/ @entity2 .

answer: @entity11


abstract: PURPOSE: To compare urinary, bowel, and sexual health-related quality-of-life (HRQOL) changes due to @entity3 ( @entity3 ) brachytherapy, low-dose-rate (LDR) brachytherapy, or intensity-modulated radiation therapy (IMRT) monotherapy for @entity1 . METHODS AND MATERIALS: Between January 2002 and September 2013, 413 low-risk or favorable intermediate-risk @entity1 @entity0 were treated with @entity3 brachytherapy monotherapy to 2700-2800  cGy in two fractions (n  = 85), @entity4 -125 LDR brachytherapy monotherapy to 14,500  cGy in one fraction (n  = 249), or IMRT monotherapy to 7400-8100  cGy in 37-45 fractions (n  = 79) without pelvic lymph node irradiation. No @entity2 deprivation therapy was given. @entity0 used an international prostate symptoms score questionnaire, an expanded @entity1 index composite-26 bowel questionnaire, and a sexual health inventory for @entity0 questionnaire to assess their urinary, bowel, and sexual HRQOL, respectively, pretreatment and at 1, 3, 6, 9, 12, and 18  months posttreatment. RESULTS: Median follow-up was 32  months. @entity3 brachytherapy and IMRT @entity0 had significantly less deterioration in their urinary HRQOL than LDR brachytherapy @entity0 at 1 and 3  months after irradiation. The only significant decrease in bowel HRQOL between the groups was seen 18  months after treatment, at which point IMRT @entity0 had a slight, but significant, @entity5 compared with @entity3 and LDR brachytherapy @entity0 . @entity3 brachytherapy @entity0 had worse sexual HRQOL than both LDR brachytherapy and IMRT @entity0 after treatment. CONCLUSIONS: IMRT and @entity3 brachytherapy cause less severe acute worsening of urinary HRQOL than LDR brachytherapy. However, IMRT causes a slight, but significant, @entity5 compared with @entity3 and LDR brachytherapy.

title: Health-related quality-of-life changes due to @entity3 brachytherapy, low-dose-rate brachytherapy, or intensity-modulated radiation therapy for XXXX .

answer: @entity1


abstract: BACKGROUND: It has recently been shown that t (12;21) (p13;q 22) is the most common molecular @entity2 in childhood @entity3 ( @entity3 ). We have analyzed this translocation in an attempt to evaluate its incidence and to monitor @entity1 ( @entity1 ) with t (12; 21) rearrangement by detection of @entity6 - @entity5 transcript in @entity0 with @entity3 . PROCEDURE: All cryopreserved bone marrow samples were analyzed using a nested reverse transcription-polymerase chain reaction (RT-PCR) method. @entity6 - @entity5 transcripts were searched for in 34 @entity3 @entity0 , including six in relapse consecutively diagnosed at our institution between 1991 and 1997. RESULTS: @entity6 - @entity5 transcripts were found in five (19%) of 27 @entity0 with B precursor @entity3 . The @entity0 with @entity4 , chromosome 11q23 rearrangement and @entity3 @entity0 did not express @entity6 - @entity5 transcripts. Moreover, @entity1 in five @entity0 with @entity6 - @entity5 transcripts were analyzed in serial samples. Although @entity6 - @entity5 transcripts disappeared soon after the beginning of chemotherapy in three of the five @entity0 , one @entity0 continued to express them for up to 21 months without recurrence and remained in continuous complete remission for seven years after the cessation of chemotherapy. The remaining @entity0 was admitted to our hospital after the second relapse but died following a failure to induce complete remission. CONCLUSION: For most @entity0 , the presence of @entity6 - @entity5 transcripts suggests excellent chemosensitivity and a favorable prognosis, but some @entity0 with these transcripts have a different outcome. The present study suggests the possibility that a persistence of @entity1 is not necessarily related to a relapse of @entity3 with @entity6 - @entity5 fusion. The prognostic significance of @entity6 - @entity5 transcript remains controversial. Further studies are needed to evaluate the relation between the @entity6 - @entity5 transcript and prognosis.

title: Persistence of @entity6 - @entity5 transcript in XXXX in long-term remission.

answer: @entity3


abstract: The purpose of the study was to assess the efficacy and tolerance of the beta1-selective beta-adrenoceptor-blocking agent @entity2 in @entity0 with @entity3 . A total of 236 outpatients (158 male and 78 female) over 21 years of age (mean age of 57 years and 60 years for @entity0 and @entity0 , respectively) were included in an open trial of 4 weeks duration. A total of 32.5% of the @entity0 were smokers. After a washout period of at least 1 week, @entity0 were initially treated with 10 mg of @entity2 o.d. for 2 weeks, after which the dose could be adjusted to 5, 15, or 20 mg in accordance with clinical criteria (efficacy, tolerance). Eighty-eight percent of the @entity0 were maintained on 10 mg of @entity2 . The frequency of @entity1 was reduced in 89% of all @entity0 : 56% became free of @entity1 . There were no differences in response as related to age and smoking habits. @entity2 was well tolerated. Beta-blocker-specific side effects were observed in 12 @entity0 (5.1%). In conclusion, @entity2 administered once daily appears to be an effective and safe antianginal agent.

title: @entity2 in the treatment of XXXX .

answer: @entity3


abstract: INTRODUCTION: Cardiac @entity1 of @entity4 is a very rare but clinically important complication. Most cardiac metastases are asymptomatic; symptoms from cardiac @entity1 were seen in advanced stage and many of these cases were reported to have a poor prognosis. So it is important to find asymptomatic cardiac @entity1 and to start chemotherapy early in order to improve the @entity0 's prognosis. CASE PRESENTATION: A 73-year-old Asian @entity0 was referred to our hospital because of a right @entity12 . He had a history of left @entity11 9 years ago. In screening echocardiography for paroxysmal @entity9 , a low echogenic @entity2 was detected in his right ventricular apex, and characteristic ST segment elevation was detected in electrocardiography. An @entity6 positron emission tomography revealed abnormal uptake in his right ventricular apex @entity2 and prostate, and a biopsy of the @entity5 showed @entity4 cells. He received systemic @entity3 , @entity10 and @entity8 chemotherapy for the @entity4 , and the @entity13 size was reduced temporarily. Finally, he died of @entity7 16 months after his first admission, but his survival period was relatively longer than previous reports. CONCLUSIONS: We experienced a case of a metastatic @entity13 from @entity4 . We found asymptomatic cardiac @entity1 by screening echocardiography and electrocardiography. Our @entity0 received systemic chemotherapy and his survival period was relatively longer than previous reports. Electrocardiography and echocardiography may be useful to find asymptomatic cardiac @entity1 of @entity2 .

title: Metastatic @entity13 from XXXX detected by transthoracic echocardiography: a case report.

answer: @entity4


abstract: The resistance to @entity10 (APC-resistance) based on the presence of @entity9 (F V Leiden) is the most frequent @entity5 in the white race population. It contributes to the origin of @entity7 especially in the venous part of blood vessels. Significant geographic differences have been detected within Europe. The aim of this retrospective study was to determine the frequency in the occurrence of F V Leiden: 1. in healthy (asymptomatic) Slovak population, 2. in their consanguineously unrelated members with @entity7 and 3. in @entity0 with @entity6 (IM) without or with other known risk factors of this disease ( @entity4 , @entity2 , @entity3 , @entity8 , @entity1 ), respectively. The detection of FV Leiden was made by molecular biology methods. The occurrence in a group of 152 healthy individuals was four % (6 @entity0 ) and this frequency corresponds to the geographic localization of the Slovak Republic in Europe. In a group of 349 @entity0 with @entity7 in anamnesis, FV Leiden was detected in 103 @entity0 (29.5%). The occurrence was higher than the usually reported incidence in these @entity0 (20%). Likewise, in a group of 35 @entity0 with IM without risk factors in anamnesis, the occurrence of FV Leiden (8.6%) was significantly higher in comparison with healthy population and the incidence further increased significantly in a group of 41 @entity0 with IM and the presence of at least one risk factor (14.6%). The authors therefore suppose an active role of the Leiden mutation of FV gene in the pathogenesis of this disease.

title: [ XXXX and the Slovak population].

answer: @entity9


abstract: OBJECTIVE: @entity2 -induced endometrial changes in postmenopausal @entity1 with @entity0 are well-known. Due to the popularity of postoperative chemotherapy for @entity0 , chemotherapy-induced @entity5 in @entity1 with @entity0 on @entity2 treatment needs more attention, because these @entity1 have higher risk for @entity4 than premenopausal @entity1 . SUBJECT: From May 1995 to May 1997, three premenopausal @entity1 aged 46, 43, and 39 with @entity0 were treated in our center. All @entity1 received standard surgery for their @entity0 followed by six courses of adjuvant chemotherapy and 5-year @entity2 treatment. All @entity1 were regularly followed-up at the @entity0 Center and evaluated annually at the gynecological clinics including pelvic examination, @entity3 smear and transvaginal sonography. RESULTS: All @entity1 became menopausal after six courses of chemotherapy ranging from three months to 14 months. The @entity4 occurred at 36 months, 28 months, and 33 months, respectively, after initial treatment for the @entity0 . Their last gynecologic examinations performed at six months, eight months and five months before the diagnosis of @entity4 showed nothing remarkable. Only one @entity1 complained of vaginal spotting before diagnosis and the other two @entity1 only complained of increasing purulent vaginal discharge. All @entity1 received standard treatment for @entity4 and none of them died of their disease but one @entity1 died of recurrent @entity0 52 months later. CONCLUSION: @entity1 with @entity0 on @entity2 treatment need more attention and frequent evaluation of their reproductive organs, especially postmenopausal (either spontaneous or chemotherapy induced) @entity1 , although the American College of Obstetricians and Gynecologists (ACOG) comments that no more than annual pelvic exams with @entity3 smears are needed in asymptomatic @entity1 .

title: @entity2 -induced XXXX .

answer: @entity4


abstract: Acute @entity3 was observed in 492 @entity0 . Fourteen (2.8%) developed an arterial erosion revealed by a @entity2 either in the digestive lumen, in the peritoneum or via previously placed drainage. The eroded artery was the splenic artery in six @entity0 , a @entity1 in five @entity0 . An initial haemostasis was attempted by: a) embolization in four @entity0 : one died; the three others had @entity2 recurrence. b) splenocorporeal pancreatectomy in four @entity0 , three had @entity2 recurrence. c) arterial ligature in four @entity0 : three had @entity2 recurrence. Secondary haemostatic procedures were performed in ten @entity0 but a durable haemostasis was achieved in only five @entity0 : two had a pancreatic resection and three were treated by a redo-binding. It is noteworthy that durable haemostasis could not be obtained neither by embolization nor by ligature in necrotic tissues. This could explain the difference in the results of arterial erosion treatments in chronic and in acute @entity3 . Therefore, it is suggested that haemostatic procedures should be performed away from necrotic tissues, or eventually done after their removal.

title: @entity1 in acute XXXX .

answer: @entity3


abstract: @entity10 ( @entity10 ) is a common side effect of @entity1 treatment. It is the most frequent cause of dose reduction or treatment discontinuation in @entity0 treated for @entity1 with commonly used drugs including @entity14 and @entity8 -based compounds. No FDA-approved treatments for @entity10 are available. In rodents, @entity10 is represented by peripheral mechanical @entity11 in association with retraction of intraepidermal nerve fibers. The mechanism of chemotherapy-induced @entity12 is unclear, but it has been established that @entity13 is an important component of the dysregulation in peripheral sensory neurons. We have shown earlier that inhibition of mitochondrial @entity6 accumulation with the small compound @entity15 -  ( @entity16 - ) prevents cerebral @entity5 in a rodent model of @entity4 . We now explore whether @entity16  is capable of preventing @entity5 and @entity10 in @entity2 . We demonstrate for the first time that @entity16  prevents both @entity9 - and @entity7 -induced mechanical @entity11 . Electron microscopic analysis of peripheral sensory nerves revealed that @entity16  secured mitochondrial integrity in @entity9 -treated @entity2 . In addition, @entity16  administration protects against chemotherapy-induced loss of intraepidermal nerve fibers in the paw. To determine whether neuroprotective treatment with @entity16  would interfere with the antitumor effects of chemotherapy, @entity3 cells were cultured in vitro with @entity16  and @entity9 . @entity15 -  does not inhibit @entity1 cell death but even enhances @entity9 -induced @entity1 cell death. These data are the first to identify @entity16 -  as a potential therapeutic strategy for prevention of @entity10 to combat one of the most devastating side effects of chemotherapy.

title: Prevention of chemotherapy-induced XXXX by the small-molecule inhibitor @entity15 .

answer: @entity10


abstract: UNASSIGNED: Footwear and offloading techniques are commonly used in clinical practice for preventing and healing of foot ulcers in @entity0 with @entity1 . The goal of this systematic review is to assess the medical scientific literature on this topic to better inform clinical practice about effective treatment. We searched the medical scientific literature indexed in PubMed, EMBASE, CINAHL, and the Cochrane database for original research studies published since May 1st 2006 related to four groups of interventions: 1) casting; 2) footwear; 3) surgical offloading; and, 4) other offloading interventions. Primary outcomes were @entity3 prevention, @entity3 , and pressure reduction. We reviewed both controlled and non-controlled studies. Controlled studies were assessed for methodological quality, and extracted key data was presented in evidence and risk of bias tables. Uncontrolled studies were assessed and summarized on a narrative basis. Outcomes are presented and discussed in conjunction with data from our previous systematic review covering the literature from before May 1(st) 2006. We included two systematic reviews and meta-analyses, 32 randomized controlled trials, 15 other controlled studies, and another 127 non-controlled studies. Several randomized controlled trials with low risk of bias show the efficacy of therapeutic footwear that demonstrates to @entity2 and is worn by the @entity0 , in the prevention of plantar foot @entity3 recurrence. Two meta-analyses show non-removable offloading to be more effective than removable offloading for @entity4 . Due to the limited number of controlled studies, clear evidence on the efficacy of surgical offloading and felted foam is not yet available. Interestingly, surgical offloading seems more effective in preventing than in healing ulcers. A number of controlled and uncontrolled studies show that plantar pressure can be reduced by several conservative and surgical approaches. Sufficient evidence of good quality supports the use of non-removable offloading to @entity4 and therapeutic footwear with demonstrated pressure relief that is worn by the @entity0 to prevent plantar foot @entity3 recurrence. The evidence base to support the use of other offloading interventions is still limited and of variable quality. The evidence for the use of interventions to prevent a first foot @entity3 or heal ischemic, infected, non-plantar, or proximal foot ulcers is practically non-existent. High-quality controlled studies are needed in these areas. This article is protected by copyright. All rights reserved.

title: Footwear and offloading interventions to prevent and heal foot ulcers and @entity2 in @entity0 with XXXX : a systematic review.

answer: @entity1


abstract: UNASSIGNED: We present the case report of a 19-year-old @entity0 with @entity6 due to chronic @entity4 , in hemodialysis (HD) by central catheter, with the incidental finding of a mass of 28x16 mm in @entity9 ( @entity9 ). The diagnosis of @entity5 , @entity7 or @entity8 were considered. Given the context of immunosuppression and difficult access vascular therapeutic practice has proved complex. Although Doppler echocardiography suggested @entity5 in @entity9 , nuclear magnetic resonance imaging (MRI) indicated for the diagnosis of @entity8 in @entity9 . In both conditions, the proposed surgical approach was limited by intense immunosuppression history and the risk of @entity1 . Throughout the treatment, the general state of K.M.F. remained satisfactory and revealed no signs or symptoms related to @entity3 . The absence of fever and negative blood cultures excluded @entity7 . Prior echocardiogram report without masses in the @entity9 decreased the chance of @entity2 . The therapeutic response to anticoagulation confirmed the diagnosis of @entity5 . After 180 days of anticoagulation, there was significant reduction in mass. The @entity0 developed asymptomatic. The diagnosis of mass in @entity9 can be a challenge and only the evolution of the case was able to guide the appropriate conduit. While MRI has high sensitivity and specificity for the diagnosis of @entity2 , the interpretation of images can be subjective. Controversial point is the removal of the catheter in such cases, which is subject discussed throughout the report.

title: XXXX in chronic hemodialysis with right atrial mass: @entity5 , fungal endocarditis or atrial myxoma?

answer: @entity0


abstract: @entity8 is an agent with a lower incidence of @entity9 and myelotoxicity compared with @entity6 ; and it is active in @entity0 with @entity12 ( @entity12 ). Our aim was to define the therapeutic efficacy and @entity2 of dose-intensified @entity8 in combination with @entity7 , @entity11 , and @entity3 (CEOP) in @entity0 with diffuse large-cell @entity12 . Previously untreated @entity0 aged between 15 and 75 years, with at least one measurable lesion, adequate liver, renal, cardiac functions, and no central nervous system involvement were included in the study. The planned chemotherapy regimen CEOP consisted of @entity7 750 mg/m2, @entity8 100 mg/m2, and @entity11 1.4 mg/m2 intravenously on day 1 and 100 mg @entity3 taken orally on days 1 to 5. Courses were repeated every 21 days. @entity0 with stage I and II received four cycles of chemotherapy followed by involved-field radiotherapy, and @entity0 with stage III and IV received six cycles of chemotherapy followed by radiotherapy to bulky lymph node sites. Seventy-five @entity0 were enrolled in the study. The complete response rate was 83.8%, and 72 @entity0 were assessable for @entity2 . The most common @entity2 was myelosuppression; 13.9% of the @entity0 had grade III-IV @entity10 . Severe @entity1 , @entity4 , and @entity5 were uncommon (<10%). At a median follow-up period of 41 months, the 5-year progression-free survival and overall survival rates were 63.5% and 65.3%, respectively. Increasing the dose intensity of @entity8 can yield a similar complete response rate compared with the regimens used in @entity12 without significantly increasing the @entity2 rate associated with chemotherapy. The role of dose-intensive @entity8 should be investigated further in future randomized trials.

title: Treatment of aggressive @entity12 with dose-intensified @entity8 in combination of XXXX , @entity11 , and @entity3 (CEOP-100): a phase II study.

answer: @entity7


abstract: STUDY OBJECTIVES: The maternal postpartum period is characterized by @entity4 , which is associated with @entity2 , @entity3 , and changes in @entity5 patterns. In addition to @entity4 , @entity0 undergo a complex set of physiological and environmental changes upon entering the postpartum period, confounding our understanding of effects of postpartum @entity1 . The primary study aim was to understand the basic impact of a single night of postpartum-like @entity4 on @entity1 , nocturnal @entity5 levels, mood, @entity1 , and neurobehavioral performance. MEASUREMENTS AND RESULTS: For one week prior to entry into the laboratory, eleven healthy nulliparous @entity0 kept a stable sleep-wake schedule (verified via actigraphy). @entity0 contributed three consecutive nights of laboratory overnight polysomnography: (1) a habituation/ @entity1 screening night; (2) a baseline night; and (3) a @entity4 night, when @entity0 were awakened three times for ~30min each. Self-reported sleep quality and mood (Profile of Mood States survey) both decreased significantly after @entity4 compared to baseline measurements. Unexpectedly, @entity1 (Multiple Sleep Latency Test) decreased significantly after @entity4 . @entity4 had no significant effect on time spent in nocturnal sleep stages, urinary @entity6 concentration, or psychomotor vigilance test performance. @entity0 continued to provide actigraphy data, and daily PVTs and self-reported sleep quality assessments at home for one week following @entity4 ; these assessments did not differ from baseline values. CONCLUSIONS: While there were no changes in measured physiological components of a single night of postpartum-like experimental @entity4 , there were decreases in self-reported measures of mood and sleep quality. Future research should examine the effects of multiple nights of modeling postpartum-like @entity4 on objective measures of sleep and daytime functioning.

title: Effects of a single night of postpartum sleep on childless XXXX 's daytime functioning.

answer: @entity0


abstract: UNASSIGNED: Abstract Background: @entity9 ( @entity10 ) is an efficacious over-the-counter analgesic/antipyretic with adverse event (AE) rates comparable to placebo. @entity10 @entity6 (IBUNa) is a newer, more soluble form that is absorbed faster than standard @entity10 , leading to more rapid analgesia. Although its safety and tolerability are expected to be comparable to standard @entity10 , this has not yet been reported. Methods: Pooled analysis comparing the safety of single-dose IBUNa (512 mg; equivalent to 400 mg @entity10 free acid; n = 362) with standard @entity10 tablets (400 mg; n = 342) and placebo (n = 187) across five Phase III, randomized, placebo-controlled, double-blind studies evaluating IBUNa for treatment of postoperative dental @entity2 , @entity7 , or @entity3 . Results: Treatment-emergent AEs (TEAEs) occurred in 5% of cases in the IBUNa group (25 events), 6.4% of cases in the standard @entity10 group (41 events), and 10.2% of cases in the placebo group (31 events). The most frequent TEAEs were in the following Medical Dictionary for Regulatory Activities (MedDRA) System Organ Classes: @entity4 (2.8, 3.2, and 5.9% for IBUNa, standard @entity10 , and placebo, respectively), @entity8 (1.4, 3.5, and 3.7% for IBUNa, standard @entity10 , and placebo, respectively), and general disorders and administration-site conditions (1.1, 1.5, and 2.1% for IBUNa, standard @entity10 , and placebo, respectively). @entity5 was the most common TEAE (2.5, 2.6, and 5.9% for IBUNa, standard @entity10 , and placebo, respectively). Only two AEs were considered related to treatment: @entity1 (n = 1, IBUNa) and @entity5 (n = 1, placebo). Of those subjects reporting >=  1 TEAE, 44.4, 36.4, and 89.5% of subjects in the IBUNa, standard @entity10 , and placebo groups, respectively, received rescue medication. Conclusion: IBUNa has a favorable safety profile comparable to those of standard @entity10 tablets and placebo in single-dose studies evaluating analgesic or antipyretic efficacy. ClinicalTrials.gov Registry Numbers: Dental @entity2 studies: NCT01098747 and NCT01216163; @entity0 studies: NCT01077973 and NCT01362491; pyresis study: NCT01035346.

title: Safety of a novel formulation of XXXX sodium compared with standard @entity9 and placebo.

answer: @entity9


abstract: BACKGROUND: Insulin resistance is associated with @entity5 , but its mechanism is unknown. It has been reported that @entity8 deficient ( @entity8 -/-) @entity1 showed insulin resistance without @entity3 2 @entity0 , whereas the @entity7 deficient ( @entity7 -/-) @entity1 showed insulin resistance with @entity3 2 @entity0 . METHODS AND RESULTS: We investigated @entity9 formation in the @entity8 -/- and @entity7 -/- @entity1 at 8 and 20 weeks. The @entity7 -/- @entity1 showed much greater @entity9 formation than the @entity8 -/- and wild- @entity3 @entity1 at 8 weeks. At 20 weeks, the @entity7 -/- @entity1 had greater @entity9 formation than the @entity8 -/- @entity1 , which showed more enhanced @entity9 formation than the wild- @entity3 @entity1 . The @entity8 -/- and @entity7 -/- @entity1 had @entity6 , @entity2 , and insulin resistance. The @entity7 -/- @entity1 had more @entity4 than the @entity8 -/- @entity1 at 8 and 20 weeks. @entity7 expression was detected, but @entity8 expression was not detected in the vessels. CONCLUSIONS: The @entity9 formation in the @entity8 -/- and @entity7 -/- @entity1 appears to be related to abnormalities induced by the altered metabolic milieu in insulin-resistant states. Moreover, because @entity9 formation was much greater in the @entity7 -/- @entity1 than in the @entity8 -/- @entity1 at 8 and 20 weeks, it is suggested that a lack of @entity7 renders the vasculature more susceptible to injury in the abnormal metabolic milieu, and @entity7 may have a protective effect on @entity9 formation. We conclude that @entity7 is protective and retards the development of @entity9 formation in insulin-resistant states.

title: Lack of @entity7 causes progressive XXXX .

answer: @entity9


abstract: OBJECTIVE: There are a few long-term follow-up studies of @entity0 with @entity1 . The objective of this study was to evaluate prognostic factors for long-term survival. METHODS: Two hundred fourteen @entity1 (registered by the Tokai @entity1 Study Group from 1988 to 1999) were analyzed. Staging according to the International Federation of Gynecology and Obstetrics was set without considering the pathologic findings of the lymph nodes. Stage Ic was divided into Ic(b) and other Ic. RESULTS: Seventy-four @entity0 were stage Ia, 2 were stage Ib, and 138 were stage Ic, consisting of 75 Ic(b) and 63 other Ic @entity0 . The ratios of stage Ic to Ia and stage Ic(b) to Ic were highest in clear-cell @entity4 among histologies analyzed. There were significant differences in disease-free survival curves between each group. In @entity5 , there was a significant difference in disease- free survival curves between stage Ic(b) and other Ic (p = 0.0373), while this tendency was also observed in other histologies except for @entity2 . Multivariate analysis demonstrated that substage was a significant prognostic factor of both disease-free and overall survival. CONCLUSIONS: Stage Ic(b) @entity0 showed poorer survival than stage Ia @entity0 but better than survival in other Ic. Thus, cautious treatment of @entity1 during surgery is quite important to avoid @entity3 .

title: Long-term prognosis of @entity1 . Prognostic importance of intraoperative XXXX .

answer: @entity3


abstract: The aim of this study was to determine how @entity4 ( @entity7 ) alters cartilage @entity1 in a @entity2 anterior cruciate ligament transection (ACLT) model of @entity5 ( @entity5 ). Thirty @entity2 underwent an ACLT on the left knee and a sham operation on the right knee. Fifteen @entity2 received weekly subcutaneous injections of @entity7 (0.14   mg/kg) and 15 @entity2 (the control [cont] group) received saline. Animal knees were divided into four groups: cont/sham, cont/ACLT, @entity7 /sham, and @entity7 /ACLT. Histological, radiological, and immunohistochemical indices were evaluated for each group. Bone volume ratios by micro-computed tomography showed that @entity7 prevented periarticular @entity6 . Histologically, the cont/ACLT group had significantly worse @entity0 than the cont/sham group 12 weeks after the surgery. However, the @entity7 /ACLT group had mild @entity3 compared with that of the @entity7 /sham group. Immunohistochemical analysis showed that @entity7 suppressed the expression of @entity9 , @entity8 , type-X collagen, vascular endothelial growth factor, and receptor activator of nuclear factor kB ligand in @entity5 cartilage. @entity7 had a chondroprotective effect in an experimental @entity2 model of @entity5 .

title: Chondroprotective effect of @entity4 in a XXXX model of @entity5 .

answer: @entity2


abstract: UNASSIGNED: Purpose. To compare the outcomes of external dacryocystorhinostomy (E-DCR) by using two different @entity2 anastomosis patterns and skin incision types. Methods. This study included 79 @entity0 (88 eyes) with lacrimal @entity1 who underwent E-DCR surgery. Fifty eyes of 44 @entity0 (group A) underwent E-DCR by suturing anterior and posterior flaps (H- @entity2 ) of the lacrimal sac with curvilinear skin incision whereas in 38 eyes of 35 @entity0 (group B) DCR was performed by suturing only anterior flaps (U- @entity2 ) with W skin incision. Results. The success rate was evaluated according to lacrimal patency and scar assessment scores. Patency was achieved in 78 @entity0 (88.6%). In terms of groups, patency was 44 eyes (88.0%) in group A and 34 eyes (89.5%) in group B. There was no statistically significant difference in the success rates of lacrimal patency between the two groups. Further, there was no statistically significant difference concerning cutaneous scar scores. Conclusion. Our study suggests that anastomoses of only anterior flaps or both anterior and posterior flaps have similar success rates; suturing only anterior flaps is easier to perform and shortens the operative time. In addition, W skin incision is a reasonable alternative to curvilinear incision for reducing scar formation.

title: Comparison of Modifications in @entity2 Anastomosis Patterns and Skin Incision Types for External Dacryocystorhinostomy: Anterior-Only @entity2 Anastomosis with W Skin Incision versus Anterior and Posterior XXXX Anastomosis with Linear Skin Incision.

answer: @entity2


abstract: OBJECTIVE: To assess the risk of @entity6 in @entity3 @entity0 undergoing surgical intervention with instrumentation for @entity5 . DATA SOURCES: A case series of 235 consecutive @entity0 who sustained @entity5 seen at Tampa General Hospital in Tampa, Florida between 1986 and 1997. STUDY SELECTION: 117 @entity0 of the 235 consecutive @entity0 included in the case series underwent surgical intervention; of these @entity0 , twelve were identified as having @entity8 . DATA EXTRACTION: Of those @entity0 treated with operative decompression and internal fixation, the authors identified and studied those with an acute wound @entity6 . These @entity0 were analyzed for risk factors and @entity6 management. DATA SYNTHESIS: Twelve (10 percent) @entity0 with @entity8 were identified. These included nine deep and three superficial @entity6 . This provides an overall @entity6 rate of 10 percent (12 of 117). Of these, there were three @entity6 in twenty-one @entity0 undergoing anterior spinal procedures. Only two of the twelve @entity0 had pure cultures of gram-positive organisms (2 @entity7 ). Cultures from eight (67 percent) @entity0 showed multiple organisms. There was a significantly (P < 0.05) higher risk of @entity6 in the @entity0 with a complete @entity1 41 percent (7/17) as compared with those with no deficit or incomplete injuries 5.0 percent (5/100). CONCLUSIONS: The overall risk of @entity6 is higher in the @entity3 @entity0 than in the elective surgery population. Those @entity0 with a @entity2 are at a greater risk. @entity4 and early intervention can help contribute to a favorable outcome.

title: Postoperative wound @entity6 after instrumentation of XXXX .

answer: @entity5


abstract: BACKGROUND: The increasing prevalence of @entity1 is considered a serious global health threat. Mainly due to change of diet and reduced physical activity, @entity1 is an important risk factor for @entity2 . A higher level of cytokines and a general inflammatory state has also been associated with this condition. With this regard, potential anti- @entity1 compounds with anti-inflammatory properties could be beneficial in better control of the disease. @entity6 is a natural aromatic compound that has been shown to have anti-inflammatory properties, while the antidiabetic drug @entity5 has been observed to be effective as an aid for @entity3 . In this study, the effect of these comounds was compared in a high fat diet treated @entity0 model. METHODS: 48 adult NMRI @entity0 were randomly divided into six groups: control group receiving a normal diet, high fat diet (HFD) fed control group, sham group receiving HFD and sunflower seed oil, Experimental group1 (E1) receiving HFD and 20  mg/kg @entity5 , Experimental group2 (E2) receiving 20  mg/kg @entity5 and 20  mg/kg @entity6 , Experimental group3 (E3) receiving 20  mg/kg @entity6 . Compounds were administered by intragastric gavage for 45  days. RESULTS: Non-fasting @entity4 serum levels, ALT, and ALP of E2 and E3 decreased significantly compared to HFD control group. In the E3 group, AST levels decrease was also significant. In E1, non-fasting @entity4 and TG serum levels decreased significantly compared to HFD control group. Histological observations on liver tissue showed an increase of lipid droplets in the HFD control group compared with the normal group, while upon treatment with the compounds, lipid droplets decreased and the cells appeared to be more ordered. CONCLUSION: @entity6 has a potential to ameliorate biochemical parameters in high fat diet treated @entity0 , and its concurrent use with @entity5 was effective.

title: Cymene and XXXX treatment effect on biochemical parameters of male NMRI @entity0 fed with high fat diet.

answer: @entity5


abstract: We compared peripheral nerve fibers and muscle fibers in @entity3 ( @entity3 ) using a computer-assisted device for morphometry. In the 17 cases with @entity3 studied, the sural nerves of 14 cases (82%) showed various degrees of @entity1 (MSA) per endoneurial area. Of these, 8 cases (47%) presented with a mild @entity1 , 5 cases (29.4%) with moderate reduction, and one case (6%) with severe reduction. The number of myelinated nerve fibers was not significantly reduced in @entity3 when compared with control nerves, due to clusters of small regenerated nerve fibers. The mean diameter of the muscle fibers in 6 of the 17 cases was less than 40 microm. Of these 6 severely affected cases, 5 revealed a considerable @entity1 . Other cases, which appeared to be normal in respect to the diameter of muscle fibers, showed various degrees of @entity1 . Thus, there is usually, but not always a morphometric correlation of the severity of changes between peripheral nerves and muscle. The severity of the @entity2 appears to depend largely on the @entity0 's age, the stage of the disorder, and the time of progression. Electron microscopic examination of sural nerves showed significant, though non-specific pathological changes.

title: Comparative morphometric evaluation of peripheral nerves and muscle fibers in XXXX .

answer: @entity3


abstract: @entity10 ( @entity10 ) is a progressive disease of striated @entity3 . Respiratory and @entity6 are particularly clinically relevant because they result in the leading causes of @entity4 in @entity10 @entity0 . Despite the clinical and physiological significance of these systems, little has been done to understand the cardiorespiratory interaction in @entity10 . We show here that prior to the onset of global @entity6 , @entity9 mdx @entity1 have @entity6 with the right ventricle being particularly affected. Using a novel biventricular cardiac catheterization technique coupled with cardiac stress testing, we demonstrate that both the right and left ventricles have significant reductions in both systolic and diastolic function in response to @entity7 . Unstimulated cardiac function is relatively normal except for a significant reduction in the ventricular pressure transient duration compared with controls. These biventricular analyses also reveal the absence of a @entity7 -induced increase in isovolumic relaxation in the right ventricle of control hearts. Simultaneous assessment of biventricular pressure demonstrates a @entity7 -dependent enhancement of coupling between the ventricles in control @entity1 , which is absent in mdx @entity1 . Furthermore, studies probing the passive-extension properties of the left ventricle demonstrate that the mdx heart is significantly more compliant compared with age-matched C57BL/10 hearts, which have an age-dependent stiffening that is completely absent from @entity6 . These new results indicate that right ventricular @entity2 is an early indicator of the development of @entity5 , suggesting a mechanism by which @entity11 may accelerate the development of @entity8 in @entity10 .

title: Early right ventricular @entity2 and reduction in biventricular cardiac reserve in the XXXX mdx heart.

answer: @entity9


abstract: BACKGROUND AND AIM: @entity0 colic is a prevalent physiological event of healthy @entity0 under 3 months of age, which can disrupt the @entity0 's home environment. Despite its benign natural history, sometimes it requires a therapeutic approach. There is limited evidence supporting the use of complementary and alternative treatments. The aim of this study was to investigate the effectiveness of a mixture of standardized extract of matricariae Chamomilla L., Melissa Officinalis L. and tyndallized @entity2 (H122) compared with @entity1 (DSM 17938) and with @entity3 for the treatment of infantile colic. @entity0 AND METHODS: A multicenter prospective, randomized comparative study was conducted involving 133 @entity0 with colic, according to Rome III criteria, who were assigned at random to receive Chamomilla L., Melissa Officinalis L. and tyndallized @entity2 (H122) (Group A; n=45), @entity1 DSM 17938 (10 CFU) (Group B; n=45) or @entity3 (GroupC; n=43). Treatment was given to subjects for 21 days and they were followed for 4 weeks. Treatment success was assessed at the end of study period. Daily crying and fussing times were recorded in a structured diary, and maternal questionnaires were completed to monitor changes in @entity0 colic symptoms and adverse events. RESULTS: Treatment success was observed in 30 out of 45 @entity0 (66.7%) of @entity0 in Group A, while it was seen in 31 out of 45 @entity0 (68.9%) of Group B and in 19 out of 43 (44.2%) of subjects of Group C (  : 6.8; p=0.03). Mean daily crying time was more significantly reduced (from 211.3  40 min/day to 69.6  59 min/day) in the Group A and in Group B (from 201.6  32.5 min/day to 58.1  48.9 min/day) when compared with Group C (from 199.5  32 min/day to 106  56.5 min/day) (p<0.01, p=0.006 respectively). No significant difference was observed comparing Group A and B (p=0.4). No adverse events were reported in any group. CONCLUSIONS: This study suggests that administration of Chamomilla L., Melissa Officinalis L. and tyndallized @entity2 (H122) and @entity1 DSM 17938 are significantly more effective than @entity3 in improving colic symptoms. Therefore, the use of herbal supplements may represent a new therapeutic strategy in the management of colicky @entity0 .

title: PP-12 EFFICACY OF A STANDARDIZED EXTRACT OF MATRICARIAE CHAMOMILLA L., MELISSA OFFICINALIS L. AND TYNDALLIZED @entity2 (H122) COMPARED WITH @entity1 (DSM 17938) AND WITH XXXX FOR THE TREATMENT OF INFANTILE COLIC.

answer: @entity3


abstract: BACKGROUND: Goblet cell carcinoid is a rare variant of @entity6 with mixed endocrine and exocrine features. The most common symptom and signs are @entity3 , @entity4 and palpable mass. Additionally, @entity3 is common in @entity0 on peritoneal dialysis, which may confound the diagnosis in such @entity0 . CASE PRESENTATION: We report a 71- years- old @entity0 on peritoneal dialysis that experienced several episodes of abdominal cramping @entity1 . She had one episode of severe @entity1 and underwent an appendectomy for suspicion of @entity5 . Goblet cell carcinoid was diagnosed. She had no further @entity3 after she received appendectomy. CONCLUSIONS: Malignant dialysate was rarely reported in @entity0 with peritoneal dialysis. However, @entity7 can initially present with @entity4 , chronic intermittent @entity3 and mimicking @entity2 . In systemically reviewing the literature, this is the first case report of @entity2 with peritoneal dialysis caused by @entity7 .

title: @entity7 presenting with recurrent @entity2 in a XXXX on peritoneal dialysis: a case report.

answer: @entity0


abstract: AIM: To evaluate the neurosensory outcome of management of damaged @entity2 caused by endodontic overfilling and to assess the efficacy of delayed surgical intervention. METHODOLOGY: Nine @entity0 who underwent surgical removal of extruded endodontic material were included. All @entity0 were evaluated for neurosensory function using a set of standardized tests. The outcome of surgical intervention was evaluated through @entity0 interview and quantitative statistical analysis. RESULTS: Surgical procedures included @entity4 , microsurgical external/internal decompression, excision of @entity3 followed by nerve repair, and excision of damaged nerve segment with interpositional nerve graft. Seven of the nine @entity0 had significant improvement according to the follow-up neurosensory assessment. Four @entity0 reported significant improvement, three @entity0 reported mild improvement and two @entity0 reported no appreciable improvement in the Visual Analog Scale (VAS). Two @entity0 who reported no appreciable improvement in VAS also did not achieve FSR. In these @entity0 , @entity5 was spread widely along the IAN and a surgical approach was obtained via sagittal spit osteotomy. The mean time to reach FSR was 222.7 (  41.8)  days with a range of 106-397  days. In the early repair group who received surgery within 60  days, three out of five @entity0 achieved FSR in a mean time of 198.0 (  76.2)  days. The mean time to FSR in all four subjects who received surgical attention over 60  days after injury was 241.3 (  139.8)  days with a range of 106-397  days. As all four cases in the late repair group with limited amount of @entity1 achieved FSR, only 3 of 5 early repair cases with wide-spread injury achieved a similar outcome. CONCLUSION: The results of this case series confirmed the notion that surgical management of the @entity2 is effective in the treatment of @entity1 caused by endodontic extrusion of @entity5 paste. Delayed surgical repair of the @entity2 can be indicated and helpful for the neurosensory recovery of damaged IAN, however, the surgical management was less effective in case of widespread @entity1 .

title: Surgical management of damaged @entity2 caused by endodontic overfilling of XXXX paste.

answer: @entity5


abstract: INTRODUCTION: Septal deviation is often found in conjunction with other pathological conditions that adversely affect nasal patency. Anterior septal deviation, together with @entity2 , is a relatively rare @entity1 . In our experience, it can often be resolved with septoplasty, without the necessity of surgery involving the external valve. The aim of this paper was to verify this hypothesis prospectively. @entity0 AND METHODS: Twelve @entity0 with anterior septal deviation and simultaneous @entity2 on the opposite side were prospectively enrolled in the study. Subjective assessment of nasal patency was made on post-operative day 1, and again 6 months after surgery, using a subjective evaluation of nasal breathing. The width of the nostril (alar-columellar distance) on the side with the @entity2 was measured during inspiration pre-operatively, 1 day after surgery and again 6 months after surgery. RESULTS: Immediately after surgery, all @entity0 reported improved or excellent nasal breathing on the side of the original septal deviation. On the collapsed side, one @entity0 reported no change in condition. With the exception of one @entity0 , all measurements showed some degree of improvement in the extension of the alar-columellar distance. The average benefit 6 months after surgery was an improvement of 4.54 mm. CONCLUSION: In our group of @entity0 (anterior septal deviation and simultaneous @entity2 and no obvious structural changes of the alar cartilage) we found septoplasty to be entirely suitable and we recommend it as the treatment of choice in such cases.

title: Anterior septal deviation and XXXX .

answer: @entity2


abstract: We evaluated the association between chlorination byproducts and @entity2 risk in a population-based case-control study conducted in Iowa in 1986-1989. Data were gathered from 685 @entity2 cases, 655 @entity1 cases, and 2,434 controls. We calculated odds ratios for the 560 @entity2 cases, 537 @entity1 cases, and 1,983 controls for whom water exposure information was available for at least 70% of their lifetime. We estimated exposure to chlorination byproducts with two types of measures: duration of lifetime at residences served by chlorinated water and estimated lifetime @entity3 exposure. For @entity1 , we observed an association with duration of chlorinated surface water use, with adjusted odds ratios of 1.1, 1.6, 1.6, and 2.6 for 1-19, 20-39, 40-59, and > or =60 years of exposure, compared with no exposure. @entity1 risk was also associated with several different measures of estimated lifetime @entity3 exposure. For @entity2 and subsites, we detected no important increase in risk associated with duration of chlorinated surface water, nor with @entity3 estimates. When we evaluated chlorination byproducts jointly with other factors, we found larger relative risk estimates for @entity1 among subjects with low dietary fiber intake. The risk related to > or =40 years of exposure to a chlorinated surface water source was 2.4 (95% confidence interval = 1.5-4.0) for @entity0 with low fiber intake and 0.9 (95% confidence interval = 0.4-1.8) for @entity0 with high fiber intake, relative to the risk of @entity0 with high-fiber diets and no exposure to chlorinated surface water. We observed a similar risk differential for low and high levels of physical activity.

title: Drinking water source and chlorination byproducts. II. Risk of XXXX .

answer: @entity2


abstract: A meta-analysis of SPECT brain imaging in @entity1 was performed to derive the sensitivity and specificity of interictal, postictal or ictal rCBF patterns to identify a @entity2 focus in medically refractory @entity0 . METHODS: Papers were obtained by pooling all published articles identified by two independent literature searches: (a) Dialnet (EMBASE) or Radline by CD-ROM and (b) Current Contents searched manually. Literature inclusion criteria were: (a) @entity0 had a localization-related @entity1 ; (b) more than six @entity0 were reported; and (c) @entity0 had at least an interictal EEG-documented @entity1 . Of 46 papers meeting these criteria, 30 contained extractable data. SPECT results were compared to localization by standard diagnostic evaluation and surgical outcome. Meta-analytic sensitivities for SPECT localization in @entity0 with @entity2 relative to diagnostic evaluation were 0.44 (interictal), 0.75 (postictal) and 0.97 (ictal). Similar results were obtained relative to surgical outcome. False-positive rates were low relative to diagnostic evaluation (7.4% for interictal and 1.5% for postictal studies) and surgical outcome (4.4% for interictal and 0.0% for postictal studies). RESULTS: The results were not dependent on tracer used (or dose), the presence of CT-identified structural abnormalities, blinding of image interpretation or camera quality (although data were more variable with low-resolution cameras). There were insufficient data for conclusions regarding extratemporal- @entity2 or @entity1 . CONCLUSION: Insights gained from reviewing this literature yielded recommendations for minimal information that should be provided in future reports. Additional recommendations regarding the nature and focus of future studies also are provided. The most important of these is that institutions using SPECT imaging in @entity1 should perform ictal, preferably, or postictal scanning in combination with interictal scanning.

title: SPECT brain imaging in XXXX : a meta-analysis.

answer: @entity1


abstract: OBJECTIVE: To investigate the status of @entity2 among @entity0 aged 14 years and older residing in Huanghua County, an @entity5 excess intake area in north China. METHODS: 4,230 @entity0 were asked to fulfill the questionnaire and 1,074 among them aged (36.97 +/- 12.83) years were accepted to be samples for the test. All subjects who were taken as samples needed to fill the questionnaire on @entity2 in detail, accept physical and ultrasound examination. Their morning fasting urine were collected for measurement of @entity6 concentration, and their sera were measured for thyroid-stimulating hormone(TSH, the third generation), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroglobulin (TG). If some @entity0 had abnormal TSH level, their free T4, free T3 and TSH receptor antibody(TRAb) were measured. RESULTS: The median level of urinary @entity6 of the sample subjects was 614.61 micrograms/L. The prevalence of clinical and subclinical @entity4 was 1.21% and 1.12% respectively; 92.3% of the clinical @entity4 were of Graves' disease and 75% of the subjects with @entity3 were TRAb positive. The average incidence of clinical @entity4 was not different between 2 periods before and after general iodinization of table salt in this area (1991-1995 and 1996-2000). The prevalence of clinical and @entity3 was 1.96% and 6.05% respectively. All the clinical @entity0 were female, among them 85.71% were TPOAb and/or TGAb positive, while only 29.23% of the subclinical @entity0 were TPOAb and/or TGAb positive. Positive TPOAb and TGAb were seen in 11.6% and 9.3% respectively of the sample subjects with an age-related increase. Positive thyroid autoantibody was more common in the female and those with abnormal TSH. The prevalence of @entity1 during the period of 1994-2000 was 91.58/100,000. CONCLUSION: The high prevalence of @entity3 and @entity1 indicates that excessive @entity5 intake in this area is not safe.

title: [An epidemiological survey of XXXX in an area with high @entity5 content in water supply].

answer: @entity2


abstract: The objective of this study was to assess the effect of @entity3 jelly application to chest tubes on the intensity and duration of @entity1 , chest tube site @entity1 and the required analgesics for @entity2 relief in coronary artery bypass graft (CABG) @entity0 . For @entity0 in group L, we applied sterile 2% @entity3 jelly on the chest tubes just before insertion, and for @entity0 in group C, we applied normal saline. Overall visual analogue scale (VAS), maximal @entity1 area with their VAS were documented postoperatively, and the frequency that button of @entity0 -controlled analgesia was pressed (FPB) and total @entity4 consumption were assessed. The number of @entity0 who complained that tube site was the most @entity1 site was significantly higher in group C than in group L (85% vs. 30% at extubation, P<0.001). The overall VAS score was significantly higher in group C than in group L (39.14  12.49 vs. 27.74  13.76 at extubation, P=0.006). After all of the tubes were removed, the VAS score decreased more in group C (5.74  4.77, P<0.001) than in group L (3.05  2.48, P<0.001). FPB and total @entity4 consumption were significantly higher in group C than in group L (73.00, 59.00-78.00 vs. 34.00, 31.00-39.25, P<0.001; 2,214.65  37.01 vs. 1,720.19  361.63, P<0.001, respectively). @entity3 jelly application is a very simple way to reduce @entity2 by reducing chest tube site @entity1 after CABG. (Clinical Trials Registry No. ACTRN 12611001215910).

title: Application of XXXX jelly on chest tubes to reduce @entity1 caused by drainage catheter after coronary artery bypass surgery.

answer: @entity3


abstract: Computerized axial tomography (CAT) of the abdomen was prospectively compared with peritoneal lavage (PL) in 19 @entity0 who sustained acute blunt @entity4 . All were selected carefully and were deemed stable, never having been in shock, and all required diagnostic PL. Seven @entity0 underwent exploratory laparotomy on the basis of CAT and PL findings. There were no negative findings at laparotomy. Three significant @entity2 , one @entity1 , and two hemoperitoneums were undetected by CAT. All seven cases explored were preceded by a grossly positive PL. Thus no @entity2 would have been missed if PL had been used alone. There were no complications of PL but one @entity0 aspirated oral contrast medium and one @entity0 developed @entity3 during CAT. Open PL required one half the time (20.6 minutes) as CAT (47.4 minutes). The total cost of CAT was approximately eight times that of PL ( 900.01 versus  116.38). In our hands, PL would seem to be significantly more sensitive with fewer false negative results than CAT of the abdomen in acute blunt @entity4 , a deviation from results of earlier reported series. CAT alone would have added cost, time, some risk, and very little information of use that would not be obtained by PL followed by surgery. Therefore before CAT replaces PL in the evaluation of adult @entity0 with blunt @entity4 , we feel that additional prospective studies are needed to better define the accuracy and sensitivity of CAT as compared with PL with regard to intraperitoneal injuries.

title: The use of computerized axial tomography versus peritoneal lavage in the evaluation of blunt XXXX : a prospective study.

answer: @entity4


abstract: OBJECTIVES: @entity0 with @entity4 are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of @entity1 . Similarly, there are few animal models concerned with the effect of exercise training on improving renal function. Therefore, we assessed the renal effects of moderate chronic treadmill exercise in a remnant kidney model of spontaneously @entity3 @entity2 (SHR) with @entity4 . We also assessed the effects of exercise and antihypertensive therapy on renal function. DESIGN AND METHODS: Eight-week-old SHR were subjected to 5/6 nephrectomy by removal of the left kidney and excision of two-thirds of the right kidney. The @entity2 were divided into four groups: (i) no exercise (Non-EX); (ii) moderate exercise with treadmill running (20 m/min, 0 grade incline for 60 min) (EX); (iii) EX with an @entity6 ( @entity6 ) inhibitor, @entity7 (2 mg/kg per day, i.p.); and (iv) EX with an angiotensin receptor antagonist, @entity8 (5 mg/kg per day, i.p.), for 4 weeks. RESULTS: Chronic EX significantly attenuated the increase in @entity5 (P < 0.01) and significantly protected against increases in the @entity1 ( @entity1 ). Both @entity7 and @entity8 with EX significantly decreased blood pressure (P < 0.001), and further decreased the @entity1 . In the stepwise multiple regression analysis, only antihypertensive drug remained in the model as a significant predictor of @entity1 (P < 0.0001). In contrast, exercise, antihypertensive drug and mean systolic blood pressure (weeks 1-4) remained in the model as a significant predictors of mean @entity5 (weeks 1-4) (all P < 0.0001). CONCLUSIONS: These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of @entity2 . Moreover, the antihypertensive therapy has additional renal-protective effects in this model of @entity2 .

title: Renal protective effects of chronic exercise and antihypertensive therapy in @entity3 @entity2 with XXXX .

answer: @entity4


abstract: BACKGROUND: The incidence of urinary stone disease has shown a steep rise in recent decades along with marked modifications in dietary habits and life- style. There has been an increased prevalence of urinary stone disease in @entity0 with @entity1 . We took up this study to determine the association of @entity1 with @entity3 in @entity0 undergoing surgical treatment. MATERIALS AND METHODS: @entity0 presenting with @entity3 for surgical management formed the study group. Body mass index (BMI) was calculated by noting the weight and height of the @entity0 . The extracted stone/stone fragments were analyzed to determine the chemical composition. Urinary pH was similarly noted in all. RESULTS: The mean BMI among the diabetics was 26.35    5.20 (range 17.75-35.60), whereas the mean BMI among the non-diabetics was 23.41    2.85 (range 17.71-31.62) (P < 0.0004). The incidence of @entity2 calculi in the diabetics was significantly high (P < 0.03). The mean urinary pH among the diabetics was 5.61    0.36 and among the non-diabetics was 6.87    0.32, which was significantly lower (P < 0.000044). CONCLUSIONS: There is a strong association between type 2 @entity1 and @entity2 stone formation. There is also a strong association between @entity1 , BMI, and also with lower urinary pH.

title: XXXX and @entity3 .

answer: @entity1


abstract: UNASSIGNED: Bleeding is a feared complication of invasive procedures in @entity0 with @entity1 and @entity3 (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets ( @entity5 ). Thromboelastography (TEG) provides a more @entity4 assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in @entity0 with @entity1 and @entity3 (defined in this study as INR >1.8 and/or platelet count <50 * 10(9) /L) who will be undergoing an invasive procedure. Sixty @entity0 were randomly allocated to TEG-guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or @entity5 if maximum amplitude (MA) was <30 mm. All SOC @entity0 received FFP and/or @entity5 per hospital guidelines. Endpoints were blood product use and @entity2 complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P   <   0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) @entity5 , and 4 (13.3%) both @entity5 . In the TEG group, none received FFP alone (P   <   0.0001 vs. SOC), 2 received @entity5 (6.7%; P   =   0.009 vs. SOC), and 3 both @entity5 (not significant). Postprocedure @entity2 occurred in only 1 @entity0 (SOC group) after large-volume paracentesis. CONCLUSIONS: In @entity0 with @entity1 and @entity3 before invasive procedures, TEG-guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in @entity2 complications. Remarkably, even in @entity0 with @entity3 , postprocedure @entity2 was rare, indicating that TEG thresholds should be reevaluated. (Hepatology 2016;63:566-573).

title: Thrombelastography-guided blood product use before invasive procedures in XXXX with severe @entity3 : A randomized, controlled trial.

answer: @entity1


abstract: PURPOSE: Among @entity0 with multiply relapsed @entity5 refractory to conventional chemotherapy, oral @entity7 has often been used for palliation. Although @entity2 was generally thought to be mild, the efficacy of such an approach remains unproven. METHODS: The authors retrospectively analyzed @entity0 with multiply relapsed or refractory @entity5 who were treated with oral @entity7 for palliation. Each course was generally 1 mg/m2/d in two divided doses, for 21 consecutive days, repeated after a 1-week rest in @entity0 without symptoms of @entity1 . Disease status was assessed by radiographic studies, urine @entity8 levels, and multiple @entity3 and biopsies. RESULTS: Twenty @entity0 between the ages of 3 and 34 (median 13 years) received 1 (n = 7), 2 (n = 3), 3 (n = 4), 4 (n = 2), 6 (n = 2), and 12 courses (n = 2). Prior treatments included multiple cycles of high-dose alkylator-based chemotherapy (n = 20), high-dose intravenous @entity7 (n = 8), myeloablative chemotherapy or radioimmunotherapy (n = 10), or experimental biologic agents (n = 16). Anti- @entity5 effects were seen in five @entity0 lasting 6 to 12 months; two additional @entity0 remained stable for 4 months. Thirteen @entity0 had @entity1 (11 after one or two cycles). @entity2 included @entity4 (n = 12) requiring a dose adjustment in three @entity0 and discontinuation of the drug in a fourth, and myelosuppression (n = 11) requiring transfusion and/or @entity6 support. CONCLUSIONS: Oral @entity7 therapy has antitumor activity in a small percentage of @entity0 with relapsed or refractory @entity5 . @entity2 , including @entity4 and myelosuppression, may necessitate a dose adjustment in this @entity0 population. Low-dose oral @entity7 may have utility in the treatment of @entity5 .

title: Oral XXXX for refractory and relapsed @entity5 : a retrospective analysis.

answer: @entity7


abstract: OBJECTIVES: To describe specific aspects of the diagnostic process of transmissible spongiform @entity2 in Spain and to evaluate the 14-3-3 protein test in cerebrospinal fluid. METHODS: The annual pattern of diagnostic certainty as well as those of demand and results of biochemical and genetic studies were studied using two sets of @entity0 , those diagnosed for the 1993-1998 period, notified to a National @entity3 Register (NCDJR), and those referred to the Tissue Bank for Neurological Research Laboratory (TBNRL). The 14-3-3 protein test was validated taking as a reference two clinical populations. RESULTS: Two-hundred and four @entity3 cases were registered at the NCDJR: 39 out of them and 28 other @entity0 had been studied at the TBNRL. The proportion of definite @entity3 cases decreased since 1996. Among those registered in 1997-1998, 35.5%, 36% and 20% had undergone 14-3-3 protein in LCR, histopathologic and genetic studies. The 14-3-3 test grave, for definite, @entity4 as compared for @entity0 with other @entity1 , the following data: 12/13 sensitivity; 33/35 specificity; and 12/14 and 33/34 predictive values of positive and negative test. Two familial cases were diagnosed by identification of mutations in the TBNRL. CONCLUSIONS: The results suggest that: a) the diagnostic certainty of @entity3 in Spain decreased due to a drop in autopsy rates; b) the 14-3-3 cerebrospinal fluid test has a high diagnostic value, and its use diffused rapid but incompletely; c) genetic studies are useful in some cases, and d) @entity3 undereporting may be considerable. @entity3 diagnosis and surveillance, are closely related and being consolidated in Spain.

title: [Diagnosis of transmissible spongiform XXXX in Spain. Population perspective].

answer: @entity2


abstract: UNASSIGNED: A central step in the initiation of chromosomal DNA replication in eukaryotes is the assembly of pre-replicative complex (pre-RC) at late M and early G1 phase of the cell cycles. Since 1973, four proteins or protein complexes, including cell division control protein 6 (Cdc6)/Cdc18, minichromosome @entity0 ( @entity0 ), origin recognition complex (ORC), and Cdt1, are known components of the pre-RC. Previously, we reported that a non-ORC protein binds to the essential element delta 9 of the @entity2 DNA replication origin ARS3001. In this study, we identified that the non-ORC protein is Sap1. Like ORC, Sap1 binds to DNA origins during cell growth cycles. But unlike ORC, which binds to asymmetric AT-rich sequences through its nine AT-hook motifs, Sap1 preferentially binds to a DNA sequence of 5-( @entity1 )nC/G @entity3 ( @entity1 )n-3. We also found that Sap1 and ORC physically interact. We further demonstrated that Sap1 is required for the assembly of the pre-RC because of its essential role in recruiting Cdc18 to DNA origins. Thus, we conclude that Sap1 is a replication-initiation factor that directly participates in the assembly of the pre-RC. DNA replication origins in @entity2 are defined by possessing two essential elements with one bound by ORC and the other by Sap1.

title: Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the XXXX @entity2 .

answer: @entity2


abstract: Elderly @entity0 with diseases of the central nervous system often show @entity1 . Before these disorders can be called pathological, they must be distinguished from the physiological effects of aging. The purpose of this study was to determine the effect of aging on @entity3 . Ninety healthy volunteers were divided into three groups (younger than 30 years; 30-50 years; older than 50 years), with 30 volunteers in each group. Visual and auditory predictive 15-degree saccades were evoked and recorded with electrooculography. Recorded parameters were peak velocity, duration, and latency. Both stimuli showed increasing latencies with increasing age and a higher peak velocity in the middle group as compared to the oldest group. The latter result was significant only for saccades to visual targets. Duration was almost identical for both patterns and all age groups. Between the age groups, latencies were significantly shorter for the saccades to auditory targets, and no differences in peak velocity occurred. The results stress the importance of an age-related assessment for saccadic parameters. The increasing latency and decreasing peak velocity in elderly @entity0 probably result from age-related @entity2 that are involved in the generation of saccadic eye movements. We found no indications of a different effect of aging through either the visual or the auditory pathway for saccadic parameters.

title: Effect of aging on saccadic eye movements to XXXX .

answer: @entity3


abstract: PURPOSE: Geographic access to care may be associated with receipt of chemotherapy but has not been fully examined. This study sought to evaluate the association between density of oncologists and travel distance and receipt of adjuvant chemotherapy for @entity2 within 90 days of colectomy. @entity0 AND METHODS: @entity0 in the National @entity1 Data Base with @entity1 , diagnosed between 2007 and 2010, and age 18 to 80 years were selected. Generalized estimating equation clustering by hospital service area was conducted to examine the association between geographic access and receipt of oncology services, controlling for @entity0 sociodemographic and clinical characteristics. RESULTS: Of 34,694 @entity0 in the study cohort, 75.7% received adjuvant chemotherapy within 90 days of colectomy. Compared with travel distance less than 12.5 miles, @entity0 who traveled 50 to 249 miles (odds ratio [OR], 0.87; P=.009) or >= 250 miles (OR, 0.36; P<.001) had decreased likelihood of receiving adjuvant chemotherapy. Density level of oncologists was not statistically associated with receipt of adjuvant chemotherapy (low v high density: OR, 0.98; P=.77). When stratifying analyses by insurance status, non-privately insured @entity0 who resided in areas with low density of oncologists were less likely to receive adjuvant chemotherapy (OR, 0.85; P=.03). CONCLUSION: Increased travel burden was associated with a decreased likelihood of receiving adjuvant chemotherapy, regardless of insurance status. @entity0 with nonprivate insurance who resided in low-density oncologist areas were less likely to receive adjuvant chemotherapy. If these findings are validated prospectively, interventions to decrease geographic barriers may improve the timeliness and quality of @entity2 treatment.

title: Association Between Geographic Access to XXXX Care, Insurance, and Receipt of Chemotherapy: Geographic Distribution of Oncologists and Travel Distance.

answer: @entity1


abstract: UNASSIGNED: The mechanistic understanding of lifestyle contributions to disease has been largely driven by work in laboratory rodent models using environmental interventions. These interventions show an array of methodologies and sometimes unclear collective conclusions, hampering clinical interpretations. Here we discuss environmental enrichment, exercise and stress interventions to illustrate how different protocols can affect the interpretations of environmental factors in disease. We use @entity2 ( @entity2 ) as an example because its @entity0 models exhibit excellent validity and @entity2 was the first genetic animal model in which environmental stimulation was found to be beneficial. We make a number of observations and recommendations. Firstly, environmental enrichment and @entity3 generally show benefits across laboratories and @entity0 models. However, the extent to which these environmental interventions have beneficial effects depends on parameters such as the structural complexity of the cage in the case of enrichment, the timing of the intervention and the nature of the control conditions. In particular, clinical interpretations should consider deprived control living conditions and the ethological relevance of the enrichment. Secondly, stress can have negative effects on the phenotype in @entity0 models of @entity2 and other @entity1 . When modeling stress, the effects of more than one type of experimental stressor should be investigated due to the heterogeneity and complexity of stress responses. With stress in particular, but ideally in all studies, both sexes should be used and the randomized group sizes need to be sufficiently powered to detect any sex effects. Opportunities for clinical translation will be guided by the 'environmental construct validity' of the preclinical data, including the culmination of complementary protocols across multiple animal models. Environmental interventions in @entity0 models of @entity2 provide illustrative examples of how valid preclinical studies can lead to conclusions relevant to clinical populations.

title: What's wrong with my XXXX cage? Methodological considerations for modeling lifestyle factors and gene-environment interactions in @entity0 .

answer: @entity0


abstract: OBJECTIVE: The aim of this study was to investigate the possible effects of age-related intracranial changes on the potential outcome of @entity0 and acute subdural @entity5 under rotational head loading. METHODS: A simulation-based parametric study was conducted using an updated and validated finite element model of a @entity1 head. The validation included a comparison of predicted brain cortex sliding with respect to the skull. Further, model material properties were modified to account for aging; predicted tissue strains were compared with experimental data in which groups of @entity1 in 2 different lifecycle stages, young adult and mature adult, were subjected to rotational @entity2 . For the parameter study, 2 age-dependent factors-brain volume and region-specific brain material properties-were implemented into the model. The models young adult and old age were subjected to several injurious and subinjurious sagittal plane rotational acceleration levels. RESULTS: Sequential analysis of the simulated @entity2 progression indicates that an increase in acute subdural @entity2 risk indicator occurs at an early stage of the @entity2 , whereas an increase in @entity0 risk indicators occurs at a later stage. Tissue stiffening from young adult to mature adult @entity1 produced an increase in strain-based thresholds accompanied by a wider spread of strain distribution toward the rear part of the brain, consistent with rotational @entity2 experiments with young adult and mature adult @entity1 . Young adult to old age brain tissue softening and @entity4 resulted in an increase in @entity0 and acute subdural @entity2 risk indicators, respectively. CONCLUSIONS: The findings presented in this study suggest that age-specific injury thresholds should be developed to enable the development of superior restraint systems for the elderly. The findings also motivate other further studies on age-dependency of @entity3 .

title: Effect of aging on brain injury prediction in rotational XXXX -a parameter study with a @entity1 finite element model.

answer: @entity3


abstract: BACKGROUND: @entity6 is a K-cell derived gut peptide with insulin-releasing activity which is rapidly degraded following release into the circulation. We hypothesized that substitution of all naturally-occurring Lys and @entity3 residues with @entity5 would lead to prolonged enzyme resistance and enhanced biological efficacy. METHODS: Peptide stability was assessed using @entity1 plasma, in vitro insulin-releasing actions evaluated in BRIN-BD11 cells and acute @entity2 -lowering and insulin-releasing actions examined in high fat fed @entity1 . For sub-chronic studies, a range of metabolic parameters and pancreatic histology were assessed in high fat fed @entity1 which had received saline vehicle or @entity6 ( @entity5 ) twice-daily for 21days. RESULTS: In contrast to native @entity6 , @entity6 ( @entity5 ) was resistant to plasma-mediated degradation and significantly stimulated insulin secretion in BRIN-BD11 cells. Acute administration of @entity6 ( @entity5 ) in high fat fed @entity1 significantly reduced blood @entity2 and increased plasma insulin concentrations. Twice-daily administration of @entity6 ( @entity5 ) in high fat fed @entity1 did not affect food intake, body weight or circulating insulin concentrations but significantly decreased blood @entity2 from day 9 onwards. Furthermore, @entity2 tolerance, @entity2 -mediated insulin secretion, insulin sensitivity and GIP-stimulated insulin-release were significantly enhanced in @entity6 ( @entity5 )-treated @entity1 . Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta-to-alpha cell ratio in @entity6 ( @entity5 )-treated @entity1 . In addition, @entity6 ( @entity5 ) exerted similar beneficial actions in ob/ob @entity1 as demonstrated by reduced blood @entity2 , superior glycaemic response and @entity2 -mediated insulin release. CONCLUSIONS: @entity6 ( @entity5 ) is resistant to plasma-mediated degradation and exerts sustained and beneficial metabolic actions in high fat fed and ob/ob @entity1 . GENERAL SIGNIFICANCE: @entity4 ( @entity5 )-modified analogues of xenin may represent an attractive therapeutic approach for type 2 @entity0 .

title: A novel chemically modified analogue of XXXX exhibits improved @entity2 -lowering and insulin-releasing properties.

answer: @entity6


abstract: We have reported that increased @entity4 concentrations in microdialysate of the cerebrospinal fluid (CSF) may be clue phenomena to elucidate mechanisms of @entity5 of intrathecal @entity7 . However, little is known about whether this is true for other local anesthetics. In this study, we compared the effects of local anesthetics on @entity4 concentrations in CSF microdialysate and neurologic and histopathologic outcome. @entity0 were assigned into 5 groups (n = 6 in each) and intrathecally received 0.3 mL of @entity1 solution (control), 2% @entity7 , 10% @entity6 , 2% @entity2 , or 2% @entity3 . Neurologic and histopathologic assessments were performed 1 wk after the administration. Intrathecal local anesthetics significantly increased @entity4 concentrations with no significant differences among the four local anesthetics. The sensory and motor functions in the @entity6 group were significantly worse than in the other groups. Characteristic histopathologic changes were vacuolation in the dorsal funiculus and chromatolytic damage of motor neurons. The extent of vacuolation of the dorsal funiculus was in the order of @entity6 = @entity7 > @entity2 > @entity3 . Although the differences among the local anesthetics cannot be explained by @entity4 concentrations, the results suggest that the margin of safety may be smallest with @entity6 . IMPLICATIONS: Large concentrations of local anesthetics administered intrathecally increased @entity4 concentrations in the cerebrospinal fluid. The margin of safety may be smallest with @entity6 .

title: A comparison of the @entity5 effects on the spinal cord of @entity7 , @entity6 , @entity2 , and @entity3 administered intrathecally in XXXX .

answer: @entity0


abstract: A @entity0 aged 6 years presented with genital precocity, enlarged testes and advanced linear growth. An ovoid mass 3-4 cm in diameter was identified by MRI scan in the right adrenal gland. Serum concentrations of LH, @entity3 , alpha-subnuit, @entity8 , @entity7 and @entity2 were persistently elevated. LH was unresponsive to bolus i.v. injection of @entity6 or to @entity6 analogue therapy. Serum FSH was normal. After removal of the @entity1 , serum LH, alpha-subunit, @entity3 and adrenal @entity4 levels fell to normal. In incubation medium of cultured disaggregated @entity1 cells, LH concentrations were greater than twice the mean serum concentration and 4-5-fold higher than in the medium of cultured non-neoplastic adrenal cells. Specific immunostaining of the @entity1 was positive for LH and alpha-subunit in many areas and these were not found in the adjacent non-neoplastic adrenal. Testicular biopsy showed almost complete spermatogenesis although germinal cell types were numerically lower than in normal @entity0 . These findings are consistent with an @entity5 secreting LH being the cause of the @entity0 's precocious puberty.

title: Luteinizing hormone secreting XXXX as a cause of precocious puberty.

answer: @entity1


abstract: OBJECTIVES: The purpose of this investigation was to determine the prevalence of sound, decayed, filled, and sealed permanent tooth surfaces for @entity0 and adolescents from three fluoridated communities in British Columbia and to develop a predictive model of sealant use that included the @entity1 status of tooth surfaces. METHODS: @entity0 in grades 2 and 3 (n = 2,715) and adolescents in grades 8 and 9 (3,317) were surveyed to determine the prevalence of sound, decayed, filled, and sealed permanent tooth surfaces. The DMFS index, modified to include incipient (D1) and cavitated (D2) lesions, was used to measure the status of all tooth surfaces. The prevalence of D1D2MF and sealed tooth surfaces was estimated by age group and tooth type. @entity2 models were developed to analyze the association between a number of independent variables and sealant use. RESULTS: About 60 percent of surveyed students had one or more sealants present, with a mean of 3.2 sealants per subject. Of all pit and fissure surfaces on permanent first molars, 23.4 percent and 20.1 percent were sealed for the 11 years and younger and 12 years and older age groups, respectively. For these same two age groups, the percentages of pit and fissure surfaces that were decayed and filled were 6.7 percent and 19.7 percent, respectively. For both age groups combined, 10.8 percent and 23.7 percent of all pit and fissure surfaces on second molars and premolars, respectively, were sealed. The prevalence of decayed and filled pit and fissure surfaces was 5.6 percent and 1.8 percent, respectively, for second molars and premolars. Premolars were being sealed at a rate of 13 to 1 compared to the number of decayed and filled surfaces. @entity2 failed to identify meaningful predictors of sealant use. CONCLUSIONS: Results from this study found an increase in the prevalence of sealants in the three communities surveyed, yet failed to identify criteria used by dentists or auxiliaries when making decisions about sealant placement. Professional education in the appropriate use of sealants may be necessary.

title: The relationship between the number of sound, decayed, and filled permanent tooth surfaces and the number of sealed surfaces in XXXX and adolescents.

answer: @entity0


abstract: INTRODUCTION: Delayed @entity6 (DCI) after @entity3 ( @entity3 ) can be reversible or progress to @entity2 . In @entity0 with a deterioration clinically diagnosed as DCI, we investigated whether CT perfusion (CTP) can distinguish between reversible @entity1 and @entity1 progressing to @entity2 . METHODS: From a prospectively collected series of @entity3 @entity0 , we included those with DCI, CTP on the day of clinical deterioration, and follow-up imaging. In qualitative CTP analyses (visual assessment), we calculated positive and negative predictive value ( @entity5 and NPV) with 95  % confidence intervals (95%CI) of a perfusion deficit for @entity4 on follow-up imaging. In quantitative analyses, we compared perfusion values of the least perfused brain tissue between @entity0 with and without @entity4 by using receiver-operator characteristic curves and calculated a threshold value with @entity5 and NPV for the perfusion parameter with the highest area under the curve. RESULTS: In qualitative analyses of 33 included @entity0 , 15 of 17 @entity0 (88  %) with and 6 of 16 @entity0 (38  %) without @entity4 on follow-up imaging had a perfusion deficit during clinical deterioration (p   =   0.002). Presence of a perfusion deficit had a @entity5 of 71  % (95%CI: 48-89  %) and NPV of 83  % (95%CI: 52-98  %) for @entity4 on follow-up. Quantitative analyses showed that an absolute minimal cerebral blood flow (CBF) threshold of 17.7  mL/100  g/min had a @entity5 of 63  % (95%CI: 41-81  %) and a NPV of 78  % (95%CI: 40-97  %) for @entity4 . CONCLUSIONS: CTP may differ between @entity0 with DCI who develop @entity4 and those who do not. For this purpose, qualitative evaluation may perform marginally better than quantitative evaluation.

title: CT perfusion during delayed @entity6 after XXXX : distinction between reversible @entity1 and @entity1 progressing to @entity4 .

answer: @entity3


abstract: OBJECTIVES: To investigate the impact of preprocedural left ventricular (LV) diastolic function on outcomes of @entity0 with postprocedural @entity2 (ARpost ) following @entity4 ( @entity4 ). BACKGROUND: The predictors and mechanisms of the increased mortality in @entity0 with ARpost are inadequately defined. METHODS: Baseline clinical and echocardiographic variables from a prospective @entity4 registry were analyzed. Preprocedural correlates of late outcomes (all-cause mortality and the composite of mortality, @entity1 , @entity3 , and new-onset @entity5 ) were examined according to the presence and severity of ARpost . RESULTS: Of the 418 @entity0 undergoing @entity4 , ARpost was present in 212 (51%): mild 36%, moderate-severe 15%. Mean follow-up was 909        489 days. All-cause mortality and composite endpoint rates were significantly increased in @entity0 with moderate-severe ARpost compared with @entity0 with either none or only mild ARpost (38, 22, 21%, P   =   0.02; and, 56, 35, 40%, P   =   0.01; respectively). Moderate-severe (though not mild) ARpost was independently associated with mortality and the composite endpoint (HR   =   1.93 [95%CI 1.15-3.14], P   =   0.01; HR   =   1.85 [95%CI 1.22-2.77], P   =   0.004], respectively). By multivariate analysis, preprocedural LV deceleration time (DT)   <   160 ms was independently associated with the risk of all-cause mortality and the composite endpoint among @entity0 with mild @entity7 (HR   =   1.74 [95%CI 1.14-2.60], P   =   0.01; and, HR   =   1.73 [95%CI 1.23-2.41], P   =   0.002, respectively) and moderate-severe ARpost (HR   =   1.81 [95%CI 1.28-2.51], P   <   0.001; HR   =   1.86 [95%CI 0.22-2.80], P   =   0.004, respectively). CONCLUSIONS: Preprocedural impairment of @entity6 , reflected by short DT, portends an adverse prognosis in @entity4 @entity0 who develop ARpost independently of other clinical and echocardiocardigraphic measures including AS severity and systolic LV function.    2015 Wiley Periodicals, Inc.

title: @entity2 following XXXX : Impact of preprocedural left ventricular diastolic filling patterns on late clinical outcomes.

answer: @entity4


abstract: Using endogenous lipid substrates, assays of lipid phosphorylation indicated that neuronal nuclei had a considerable superiority in @entity3 (PA) formation when compared with homogenates and other subfractions of cerebral cortex. This predominance of neuronal nuclear PA labelling was linked to a sizable pool of nuclear @entity4 that expanded significantly with incubation. PA was also the dominant product of neuronal nuclear lipid phosphorylation reactions. Nuclear envelope preparations and the parent neuronal nuclei showed specific rates of PA formation that were comparable, based upon membrane phospholipid contents. As well, using an exogenous @entity0 substrate, the distribution of @entity0 kinase activities closely followed phospholipid contents of subfractions derived from the neuronal nucleus during envelope preparation. This evidence suggested an association between @entity0 kinase and the neuronal nuclear envelope. Nuclear PA formation increased in the presence of @entity1 , while @entity1 decreased PA formation in other subfractions. Likely @entity1 exerted its effect on nuclear @entity0 kinase, as @entity1 did not elevate levels of nuclear @entity4 . @entity2 was present in the nuclei and inhibitors of this enzyme did decrease PA formation, indicating @entity4 from inositides as substrates for nuclear @entity0 kinase. The nuclear envelope fraction had a considerably lower specific @entity2 activity than the parent nuclei, and showed an activation of PA formation by @entity1 , but a less efficient handling of the exogenous @entity0 substrate. It is possible that @entity2 and @entity0 kinase are closely situated within the neuronal nuclei, and a loss of the former activity may compromise the latter.

title: XXXX is the prominent product of endogenous neuronal nuclear lipid phosphorylation, an activity enhanced by @entity1 , linked to phospholipase C and associated with the nuclear envelope.

answer: @entity3