abstract: BACKGROUND: @entity2 is a chronic @entity1 with increasing prevalence worldwide and a considerable burden especially among @entity0 . To circumvent the problems related to oral @entity3 ( @entity5 ) we aimed to evaluate its topical variant and assess its efficacy in @entity0 aged 2-18. MATERIALS AND METHODS: In a single-blind trial, we randomized the @entity0 into two groups, one treated with topical emollient containing @entity5 and @entity4 (BM), and the other treated solely with topical emollient of BM. The treatments were administered twice a day for 8 weeks in both groups. The efficacy, recurrence, and the presence of side effects were evaluated using SPSS 20. RESULTS: The amount of reduction in severity scoring for @entity2 (SCORAD) score was significantly greater in the group treated with the topical @entity5 (P = 0.024). Incidentally, there were no difference between two treatments in difference in proportions of recurrence and adverse effects as well as SCORAD reduction in subgroups of sex and age (all P > 0.05). CONCLUSIONS: Our results showed the superiority of topical @entity5 over BM with a low recurrence and adverse effects. No expectation of severe side effects, like those of oral @entity5 , is the major advantage of topical @entity5 . The sample size was an issue in uncovering the value of @entity5 in the subgroups. Conducting prolonged studies of quality-of-life and comparing the topical @entity5 potency relative to the common alternatives are recommended areas of future work.

title: Efficacy of topical @entity3 and @entity4 versus @entity4 -only emollient cream in 2-18 years old @entity0 with moderate-to-severe XXXX : A randomized controlled trial.

answer: @entity2


abstract: OBJECTIVE: To study factors associated with @entity1 , final dose, and efficacy of @entity6 ( @entity7 ) in @entity0 with @entity3 ( @entity3 ). METHODS: Data were used from a randomised clinical 48 week trial on 411 @entity0 with @entity3 all treated with @entity7 , comparing folates and placebo. Logistic regression was used to study the relation between baseline variables and various dependent factors, including hepatotoxicity ( @entity4 aminotransferase >/=3 x upper limit of normal), @entity7 withdrawal, final @entity7 dose >/=15 mg/week, and @entity7 efficacy. RESULTS: Addition of folates to @entity7 treatment was strongly related to the lack of hepatotoxicity. Next to this, high body mass index was related to the occurrence of hepatotoxicity. Prior gastrointestinal (GI) events and younger age were related to the adverse event, @entity2 . Hepatotoxicity and GI adverse events were the main reason for @entity7 withdrawal, which in turn was associated with the absence of @entity8 supplementation, body mass index, prior GI events, and female sex. Renal function ( @entity5 clearance >/=50 ml/min) was not associated with @entity1 . Reaching a final dose of @entity7 of >/=15 mg/week was related to @entity8 supplementation and the absence of prior GI events. Efficacy of @entity7 treatment was associated with low disease activity at baseline, male sex, use of non-steroidal anti-inflammatory drugs (NSAIDs), and lower @entity5 clearance. CONCLUSIONS: @entity7 @entity1 , final dose, and efficacy are influenced by @entity8 supplementation. Baseline characteristics predicting the outcome of @entity7 treatment are mainly prior GI events, body mass index, sex, use of NSAIDs, and @entity5 clearance.

title: Factors associated with @entity1 , final dose, and efficacy of XXXX in @entity0 with @entity3 .

answer: @entity6


abstract: UNASSIGNED: A @entity0 in his 50s presented to a rural Australian emergency department with complete unilateral @entity5 following transurethral resection of the prostate. His hearing impairment progressed from 'muffled hearing' with @entity4 on emergence from anaesthesia, to total @entity8 by day three. His surgery and anaesthesia were uncomplicated and he had remained normotensive throughout. He had no pre-existing @entity9 . He had received 240   mg of intravenous @entity7 intraoperatively for surgical prophylaxis. Renal function was normal. Brain imaging was negative for structural pathology, @entity2 and circulatory insufficiency. Ear nose and throat advised 7   days of oral @entity3 , transtympanic @entity6 and hyperbaric @entity1 therapy. A working diagnosis of @entity7 -induced @entity9 was applied. Intervention has proven unsuccessful and there is no possibility for rehabilitation. The @entity0 is permanently disabled.

title: XXXX following routine transurethral resection of the prostate.

answer: @entity8


abstract: A collaborative study on the laboratory diagnosis of @entity2 was carried out in three laboratories. A standardized @entity1 ( @entity1 ) test with chlamydial (bedsonial) group antigen was found to be highly reproducible. The results obtained by different laboratories using the method and reagents suggested by the WHO International Reference Centre for @entity2 and other @entity0 agreed in more than 95% of the tests. Similar agreement was observed between the results obtained with these reagents and those routinely used in one of these laboratories. In confirmation of previous studies, the @entity1 test was found to give positive results in only a limited proportion of @entity2 cases. However, in an area where the disease is hyperendemic the rates showed good correlation with the intensity of clinical signs. A comparison was also made between Giemsa staining and a fluorescent antibody (FA) technique for the cytological examination of conjunctival scrapings. The results obtained with the former method correlated well with clinical activity but the positivity rate was lower than that obtained by the FA technique. The FA results, however, were not an accurate indicator of clinical intensity. These results suggest that the Giemsa method may detect only the most heavily infected individuals.

title: Laboratory diagnosis of XXXX : a collaborative study.

answer: @entity2


abstract: BACKGROUND: To demonstrate the value of ophthalmic endoscopy in treating @entity0 with severe vision-threatening @entity6 in whom visualization through the anterior ocular structures is compromised. METHOD: In this retrospective study of @entity0 with @entity6 operated on with the use of an endoscope between 1997 and 2003, demographics, cause of @entity6 , @entity3 , comorbid factors, complications, intraoperative retinal appearance, etiology, and additional procedures required were recorded. RESULTS: Fifteen @entity0 were included. A variety of causes were observed: @entity6 (n=3), penetrating @entity1 (n=2), post- @entity4 extraction (n=7), @entity5 (n=2), and post-retinal detachment surgery (n=1). Six-month follow-up is reported. Positive cultures were obtained in all but one case. Several @entity0 had @entity2 pathogenic organisms. Eight @entity0 retained useful vision. Six of eight @entity0 without @entity7 by endoscopic examination had improved vision, with final visual acuity varying between counting fingers and 20/20. Only 1 of 6 @entity0 with @entity7 retained useful vision at 20/50. CONCLUSION: The ophthalmic endoscope aids in performing safe, diagnostic, and therapeutic vitrectomy in @entity6 . Prognosis is dependent on preoperative visual acuity and retinal appearance seen at the time of endoscopic surgery.

title: Managing severe XXXX with the use of an endoscope.

answer: @entity6


abstract: OBJECTIVE: The provision of 'adequate @entity2 ' (which reduces the @entity1 score by >= 2 and to <4 [0-10 scale]) is significantly associated with high levels of satisfaction with @entity1 management among adult @entity0 . We aimed to determine the variables (including 'adequate @entity2 ') associated with parent satisfaction with their @entity0 's @entity1 management. METHODS: We undertook an observational, pilot study in a mixed, metropolitan ED. @entity0 aged 4-16 years with a triage @entity1 score of >= 4 were enrolled. Data included demographics, presenting complaint, @entity1 scores every 30 min, @entity2 administered, time to first @entity2 , provision of nurse-initiated @entity2 (NIA), and 'adequate @entity2 ', and parent satisfaction 48-h post-discharge (6 point scale: very unsatisfied - very satisfied). RESULTS: Complete data were collected on 185 @entity0 : mean (SD) age 10.4 (3.6)   years, weight 41.9 (17.8)   kg; 93 (50.3%) were male. One hundred and ten (59.4%) parents were very satisfied with their @entity0 's @entity1 management. @entity0 of very satisfied parents had shorter times to @entity2 than those who did not (median [interquartile range] 14 (33) vs 33 (46) min, respectively, P   =   0.003). Parents whose @entity0 received NIA or 'adequate @entity2 ' were more often very satisfied than those whose @entity0 did not. However, the differences were not significant (difference in proportions: 13.2% [95% CI -1.9, 28.3], P   =   0.07 and 10.2% [95% CI -5.02, 25.34], P   =   0.16, respectively). CONCLUSION: Short times to @entity2 are associated with parent satisfaction. There were non-significant trends towards high levels of satisfaction following the provision of NIA and 'adequate @entity2 '. These findings will inform a well-powered study to confirm this association.

title: Variables associated with parent satisfaction with their XXXX 's @entity1 management.

answer: @entity0


abstract: BACKGROUND: Several studies have shown that cultured skin fibroblasts from @entity0 with @entity4 ( @entity4 ) exhibit a @entity5 growth phenotype. Increased DNA synthesis in cells from @entity0 with @entity4 may ultimately involve alterations in cell cycle regulatory proteins. @entity3 protein is a member of @entity3 family of cyclin-dependent kinase inhibitors, which plays an important role in cell cycle regulation. In this study, we examined the correlation between @entity3 protein expression in cultured dermal fibroblasts from type 1 @entity1 @entity0 and the presence of @entity4 . METHOD: Western blot analysis was performed to compare @entity3 protein expression in skin fibroblasts from @entity0 with @entity4 as compared to control subjects, @entity1 @entity0 without @entity4 , and nondiabetic @entity0 with @entity2 . Transcriptional regulation of the @entity3 gene was assessed using competitive reverse transcription-polymerase chain reaction (RT-PCR). Methylation status of the promoter region of @entity3 was examined using methylation-specific PCR, and we used single-stranded conformational polymorphism (SSCP)-PCR to assess @entity3 single-nucleotide polymorphism. RESULTS: Cells from @entity1 @entity0 with @entity4 had nondetectable to significantly lower protein expression of @entity3 . Similarly, mRNA expression of @entity3 was significantly lower in @entity1 @entity0 with @entity4 . No hypermethylation of @entity3 gene was detected, and no abnormal migrating bands were noticed on SSCP-PCR analysis in cells from @entity0 with @entity4 . CONCLUSION: Our data indicate that cells from @entity0 with @entity4 exhibit significantly lower protein and mRNA expression of @entity3 . This study could have not only important implications for the understanding of the pathogenesis of @entity4 , but also the absence of @entity3 may ultimately serve as an early marker for @entity4 .

title: Epigenetic and genetic analysis of @entity3 in dermal fibroblasts from type 1 XXXX @entity0 with @entity2 .

answer: @entity1


abstract: We reviewed 87 @entity0 with @entity1 who were admitted to King Chulalongkorn Memorial Hospital, Bangkok, Thailand, from January 1995 to December 1999; 76% of them had sustained blunt @entity2 and 24% penetrating @entity2 . Their injury severity scores (ISS) ranged from 4 to 57 (mean 20.94+/-12.8); 50% of them were in shock on arrival; 8.1, 28.7, 25.3, 19.5, and 18.4% suffered from @entity1 graded I, II, III, IV, and V, respectively. Seventeen @entity0 (19.5%) were successfully managed non-operatively; three of them underwent hepatic angiography, which in two revealed leakage of contrast medium from the right hepatic artery; both were successfully treated by embolization. One @entity0 had bile leakage and collection, which was successfully treated by ultrasound-guided percutaneous drainage. Seventy @entity0 (80.5%) underwent exploratory laparotomy; nine of them died in the operating room. Of the remaining 61 who left the operating room alive, 21 had perihepatic packing, which was frequently used in those with injuries to segments V, VI, VII, and @entity3 (Couinaud's nomenclature). Eight @entity0 who had packing and one who had not died in the postoperative period. Two @entity0 who had packing underwent subsequent hepatic angiography with embolization before successful pack removal. The overall mortality was 20.7%. The mortality in complex @entity1 (grades IV and V) was 13 out of 33 (39.4%). We believe that non-operative management should be considered in haemodynamically stable @entity0 . Angiography with embolization is invaluable in improving outcome in both non-operative and operative @entity0 . Perihepatic packing is life-saving in complex @entity1 that cannot be effectively treated by simple surgical procedures. Finally, ultrasound- or CT-guided percutaneous drainage of bile leakage or collections spared a number of @entity0 from open and complicated surgery.

title: A multidisciplinary approach in the management of XXXX .

answer: @entity1


abstract: PURPOSE: To report the technique, timing, and outcomes of the @entity3 drainage device in eyes with the modified osteo-odonto-keratoprosthesis (MOOKP) and the role of an additional stage 1A to the Rome-Vienna protocol. DESIGN: Retrospective interventional case series. METHODS: Case records of 22 eyes of 20 @entity0 with high intraocular pressure at various stages of the MOOKP procedure performed in 85 eyes of 82 @entity0 were studied. Stage 1A, which includes total iridodialysis, intracapsular @entity2 extraction, and anterior vitrectomy, was done in all eyes as the primary stage. RESULTS: Seventeen @entity3 drainage devices were implanted in 15 eyes of 14 @entity0 ( @entity1 in 9 [10 eyes] and @entity5 in 5 @entity0 ). Implantation was performed during and after stage 1A in 2 and 7 eyes, respectively, after stage 1B+1C in 1 eye, and after stage 2 in 6 eyes. Eleven of 15 eyes (73.3%) remained stable with adequate control of intraocular pressure over a mean follow-up period of 33.68  months (1-90  months). Complications related to the drainage device were @entity4 . CONCLUSION: It is ideal to place the @entity3 drainage device prior to the mucosal graft when the anatomy of the ocular surface is least altered with best outcomes. The technique of placement of the drainage device during the various stages of the MOOKP procedure has been described. The intraocular pressure stabilized in three quarters of the eyes with pre-existing @entity3 .

title: @entity3 in Modified Osteo-odonto-keratoprosthesis Eyes: Role of Additional Stage 1A and XXXX Drainage Device-Technique and Timing.

answer: @entity3


abstract: OBJECTIVE: To obtain information on the presenting symptoms, location, sex distribution, age, endoscopic appearance, histopathology, suitable treatment and recurrence of @entity3 , a rare, benign lesion of the urinary tract mucosa. @entity0 AND METHODS: The records of 31 @entity0 with @entity3 diagnosed at the Sahlgrenska University Hospital between 1980 and 1996 were reviewed to determine the symptomatology, imaging investigations, endoscopic presentation, clinical outcome after resection and the frequency of recurrence. RESULTS: The lesions were found in the urinary bladder, bulbar urethra, urethral diverticula and the prostatic urethra. Eight @entity0 presented with haematuria, 13 complained of urinary frequency and @entity5 and in 12 @entity0 without subjective symptoms from the urinary tract, the lesion was found accidentally. Twenty-seven of the @entity0 had a history of previous urothelial trauma, either by instrumentation or @entity2 . Seventeen of the lesions were polypoid at endoscopy, the remainder being flat except for two cases, in which they were not noted because they were concealed in another lesion to be resected. Seven @entity0 had one or more recurrences. All @entity0 with symptoms responded well to transurethral resection. CONCLUSION: @entity3 mimics @entity1 or @entity4 and it is rarely suspected on clinical grounds; instead, the diagnosis is almost always histological. This study supports the view that @entity3 may represent a metaplastic response to trauma of the urothelium and that transurethral resection provides a good method of relieving the symptoms in symptomatic @entity3 .

title: XXXX --a study with special reference to clinical presentation.

answer: @entity3


abstract: A selection experiment utilizing @entity4 was initiated to study the genetic relationship of growth and reproduction traits. In this study, lines were selected for increased ( @entity3 line) and decreased (LP line) total plasma @entity2 at the beginning of lay. The @entity3 and LP lines were derived from a randombred control population (R1 line) that was maintained with the selected lines to remove environmental variation over generations. During the course of selection, it was observed that blood from @entity3 line females was more viscous than that of the LP and R1 females. In later generations of selection, mortality of females during a 120-d egg production period was higher in the @entity3 line than in the LP and R1 lines. The purpose of this experiment was to identify possible factors contributing to the increased mortality in the @entity3 line. Fearfulness, as measured by tonic immobility, was greater in the @entity3 and LP lines than in the R1 line. Indirect blood pressure measurements were made near the beginning and near the end of the 120-d egg production period. No significant line differences were observed in either measurement. Weight of the heart at the end of the laying period was higher in the @entity3 and LP lines than in the R1 line. Histological study of the hearts of the @entity3 and R1 lines indicated significant @entity3 line in collagen content of the coronary arteries and in @entity0 . The data suggest that the increased mortality of females of the @entity3 line relative to the R1 line during the laying period may be related to increased fearfulness and changes in the coronary structure leading to @entity1 .

title: The effect of divergent selection for total plasma XXXX in @entity4 on fearfulness and selected blood and heart parameters.

answer: @entity2


abstract: @entity5 ( @entity3 ) is the major excitatory neurotransmitter in the central nervous system. The role of peripheral @entity3 and @entity3 receptors (GluRs) in nociceptive transmission is, however, still unclear. In the present study, we examined @entity3 levels released in the subcutaneous perfusate of the @entity0 hind instep using a microdialysis catheter and the thermal withdrawal latency using the Plantar Test following injection of drugs associated with GluRs with/without @entity6 into the hindpaw. The injection of @entity6 into the @entity0 hind instep caused an increase of @entity3 level in the s.c. perfusate. @entity6 also significantly decreased withdrawal latency to irradiation. These effects of @entity6 were inhibited by pretreatment with @entity7 , a @entity8 ( @entity8 ) competitive antagonist. @entity6 -induced @entity3 release was also suppressed by combination with each antagonist of ionotropic GluRs (iGluRs: @entity2 / @entity1 receptors) and group I metabotropic GluR (mGluR), but not group II and group III mGluRs. Furthermore, these GluRs antagonists showed remarkable inhibition against @entity6 -induced thermal @entity4 . These results suggest that @entity3 is released from the peripheral endings of small-diameter afferent fibers by noxious stimulation and then activates peripheral iGluRs and group I mGluR in development and/or maintenance of nociception. Furthermore, the activation of peripheral @entity2 / @entity1 receptors and group I mGluR may be important in mechanisms whereby @entity6 evokes nociceptive responses.

title: @entity6 -induced XXXX release is implicated in nociceptive processing through activation of ionotropic @entity5 receptors and group I metabotropic @entity5 receptor in primary afferent fibers.

answer: @entity5


abstract: BACKGROUND: @entity2 ( @entity2 ) during pregnancy represents an important cause of maternal and foetal morbidity and mortality. Approaches to diagnostics and treatment are still controversial and there are only a limited number of cases described in the literature. Our study examines the management of @entity2 in pregnant @entity0 creating a case series by combining @entity0 from our hospital records with those from the limited available literature. METHODS: Data collected from Addenbrooke's Hospital records and cases published between January 1995 and January 2015 were studied. Chi-squared test, exact Fisher's test, and chi-squared test for trend were used for analyzing categorical data, whilst t-test and U Wilcoxon-Mann-Whitney test for continuous data. RESULTS: 52 @entity0 were included. The mean age was 31.47  5.80 and most @entity0 were in their third trimester. A univariate pooled data analysis suggested that the maternal outcome may depend on mother's age, mother's Hunt and Hess score and Glasgow @entity3 Scale at arrival, treatment modality for the @entity1 , mode and timing of delivery. However, at the multivariate analysis only the presence of general complications resulted to significantly impact on maternal outcome. CONCLUSIONS: @entity4 in pregnant @entity0 with @entity2 may be safely secured in a timely manner. The diagnostic and treatment strategy for each of these @entity0 should consider peculiar maternal and obstetric factors and requires a multidisciplinary assessment involving obstetrics, neurosurgeons and intensivists. Considering the observed statistical power of our series, our findings should be taken with caution and should be supported by further systematic data collection.

title: XXXX in Pregnancy - case series, review and pooled data analysis.

answer: @entity2


abstract: PURPOSE: The identification of @entity2 pathologic characteristics is an important part of @entity0 diagnosis, prognosis, and treatment planning but currently requires biopsy as its standard. Here, we investigated a noninvasive quantitative ultrasound method for the characterization of @entity0 in terms of their histologic grade, which can be used with clinical diagnostic ultrasound data. METHODS: Tumors of 57 locally advanced @entity0 @entity1 were analyzed as part of this study. Seven quantitative ultrasound parameters were determined from each @entity2 region from the radiofrequency data, including mid-band fit, spectral slope, 0-MHz intercept, scatterer spacing, attenuation coefficient estimate, average scatterer diameter, and average acoustic concentration. Parametric maps were generated corresponding to the region of interest, from which four textural features, including contrast, energy, homogeneity, and correlation, were @entity2 characterization parameters. Data were examined on the basis of @entity2 subtypes based on histologic grade (grade I versus grade II to III). RESULTS: Linear discriminant analysis of the means of the parametric maps resulted in classification accuracy of 79%. On the other hand, the linear combination of the texture features of the parametric maps resulted in classification accuracy of 82%. Finally, when both the means and textures of the parametric maps were combined, the best classification accuracy was obtained (86%). CONCLUSIONS: Textural characteristics of quantitative ultrasound spectral parametric maps provided discriminant information about different types of @entity0 . The use of texture features significantly improved the results of ultrasonic @entity2 characterization compared to conventional mean values. Thus, this study suggests that texture-based quantitative ultrasound analysis of in vivo @entity0 can provide @entity2 histologic characteristics.

title: Noninvasive characterization of locally advanced XXXX using textural analysis of quantitative ultrasound parametric images.

answer: @entity0


abstract: BACKGROUND: Little is known about the quality of life of @entity0 who are allergic to insect venom. This fact is due to the lack of specific instruments assessing the interaction of type 1 @entity1 and its psychological burden. @entity0 AND METHODS: The only established questionnaire on health-related quality-of-life in @entity0 with wasp venom @entity1 is the "Vespid Allergy Quality of Life Questionnaire" (VQLQ). This questionnaire was translated from Dutch into German and validated with 79 @entity0 with wasp venom @entity1 , including the use of the well-established general quality-of-life questionnaire WHOQOL-BREF. RESULTS: In the German version VQLQ-d we could reproduce the validity and reliability of the original Dutch version. Cronbach's alpha of the VQLQ-d was a= 0.95. The results of the VQLQ-d corresponded to the total score of the WHOQOL-BREF. CONCLUSION: The VQLQ-d enables measurement of quality-of-life in @entity0 with wasp venom @entity1 in the German-speaking population. This economic tool makes it possible to better describe and treat affected @entity0 . Furthermore, it can be used to advance research in this field.

title: Quality-of-life in wasp venom XXXX - validation of the German version of the "Vespid Allergy Quality of Life Questionnaire" (VQLQ-d).

answer: @entity1


abstract: UNASSIGNED: OBJECT Frequent complications of posterolateral instrumented fusion have been reported after treatment of @entity2 in elderly @entity0 . Considering that in some cases, most of the symptomatology of @entity2 ( @entity2 ) is a consequence of the segmental instability at the dislocated level, the use of minimally invasive anterior lumbar interbody fusion (ALIF) to manage symptoms can be advocated to reduce surgical morbidity. The purpose of this study was to evaluate the midterm outcomes of 1- or 2-level minimally invasive ALIFs in @entity2 @entity0 with 1- or 2-level dislocations. METHODS A total of 47 @entity0 (average age 64 years; range 43-80 years) with 1- or 2-level ALIF performed for @entity2 (64 levels) in a single institution were included in the study. An independent spine surgeon retrospectively reviewed all the @entity0 ' medical records and radiographs to assess operative data and surgery-related complications. Clinical outcome was reported using the Oswestry Disability Index (ODI) and the visual analog scale (VAS) for lumbar and leg @entity1 . Intraoperative data and complications were collected. Fusion and risk for adjacent-level degeneration were assessed. RESULTS The mean follow-up duration was 3 years (range 1-10 years). @entity6 VAS scores were significantly improved at last follow-up. A majority of @entity0 (74%) had a statistically significant improvement in their ODI score of more than 20 points at latest follow-up and 1 had a worsening of his disability. The mean operating time was 166 minutes (range 70-355 minutes). The mean estimated @entity3 was 410 ml (range 50-1700 ml). Six (5 major and 1 minor) surgical complications (12.7% of @entity0 ) and 13 (2 major and 11 minor) medical complications (27.7% of @entity0 ) occurred without @entity4 or wound @entity5 . Fusion was achieved in 46 of 47 @entity0 . Surgery resulted in a slight but significant decrease of the Cobb angle, and improved the pelvic parameters and @entity7 , but had no effect on the global sagittal balance. At latest follow-up, 9 @entity0 (19.1%) developed adjacent-segment disease at a mean of 2 years' delay from the index surgery; 4 were symptomatic but treated medically, and none required iterative surgery. CONCLUSIONS Single- or 2-level minimally invasive fusion through a minimally invasive anterior approach in some selected cases of @entity2 produced a good functional outcome with a high fusion rate. They were associated with a significantly lower rate of complications in this study than the historical control.

title: Minimally invasive anterior lumbar interbody fusion for XXXX with 1 or 2 dislocated levels.

answer: @entity2


abstract: OBJECTIVE: To compare the difference in the efficacy between acupuncture and oral administration of @entity5 and the expressions of neurotransmitters in @entity0 of @entity1 differentiated as liver stagnation transforming into fire. METHODS: Seventy @entity0 of @entity1 differentiated as liver stagnation transforming into fire were randomized into an observation group and a control group, 35 cases in each one. In the observation group, acupuncture therapy was adopted at Shenmen (HT 7), Baihui (GV 20), Yintang (GV 29), Hegu ( @entity8 ), Taichong ( @entity7 ), etc. The needles were retained for 20 min each time. The treatment was given once a day, the treatment of 2 weeks made one session. In the control group, @entity5 , 100 mg, oral administration, once a day, the treatment of 2 weeks made one session. Two sessions were required in the two groups. The scores in Pittsburgh sleep quality index (PSQI) and Asberg rating scale for side effects (SERS), the levels of neurotransmitters such as @entity2 ( @entity2 ) and @entity3 (NE) and the expressions of @entity6 ( @entity6 ) and @entity4 ( @entity4 ) in peripheral blood were observed before and after treatment in the two groups. RESULTS: PSQI score and SERS score after treatment were all decreased compared with those in both groups before treatment (both P<0. 05). After treatment, PSQI score and SERS score in the observation group were lower apparently than those in the control group (both P<0. 05). After treatment NE content and @entity6 level were decreased; @entity2 content and @entity4 mRNA were increased compared with those in both groups before treatment (all P<0. 05). NE content and @entity6 level in the observation group were lower apparently than those in the control group (both P<0. 05). The serum @entity2 content and @entity4 mRNA expression in the observation group were higher than those in the control group separately (both P<0. 05). CONCLUSION: Acupuncture therapy improves the sleeping quality of @entity0 of @entity1 differentiated as liver stagnation transforming into fire, and reduces serum NE level and increases @entity2 content and @entity4 expression, which achieves the better efficacy as compared with the oral administration of @entity5 . It is one of the effective approaches to the treatment of @entity1 differentiated as liver stagnation transforming into fire.

title: [Expressions of neurotransmitters in @entity0 of XXXX differentiated as liver stagnation transforming into fire treated with acupuncture].

answer: @entity1


abstract: @entity1 intestinal trefoil factor ( @entity11 ) is a small @entity8 -rich protein expressed in the gastrointestinal (GI) tract. Its sequence is related to that of other trefoil peptides including the @entity10 / @entity10 protein, which is regulated by @entity9 in @entity0 . This study was designed to investigate whether @entity11 is expressed in @entity1 @entity6 cells. cDNA was obtained by reverse transcription-polymerase chain reaction (RT-PCR) of gastric mucosal RNA and sequenced, establishing that this mRNA is expressed in the stomach. Expression of @entity11 was detected in a proportion of cell lines derived from @entity2 of the GI tract, in @entity5 cells, and at highest levels in a @entity4 cell line. Amongst @entity0 cell lines, it was expressed in all the @entity9 -responsive but in none of the @entity9 -nonresponsive @entity0 cell lines. The possibility that @entity11 expression in breast cells is controlled by @entity3 was then tested. @entity3 treatment increased @entity11 expression between three- and ten-fold in the @entity9 -responsive @entity0 cell lines, demonstrating that, like @entity10 / @entity10 , @entity11 is regulated by @entity9 in @entity0 cells. @entity7 inhibited the induction of @entity11 expression by @entity3 but @entity7 alone was a partial @entity9 agonist for @entity11 expression. These results show that @entity11 is expressed, sometimes ectopically, in several @entity1 @entity2 , which suggests that trefoil peptides may have a more general role in tumourigenesis than hitherto appreciated. That the expression of @entity11 is regulated by @entity9 in @entity0 cells suggests that @entity11 expression may provide a novel marker for @entity9 responsiveness in @entity0 .

title: Expression of @entity1 intestinal trefoil factor in malignant cells and its regulation by XXXX in @entity0 cells.

answer: @entity9


abstract: @entity5 is very common during childhood and few @entity0 develop complications. The most frequent complications are @entity11 , @entity15 and @entity1 . In the nervous system it can produce @entity4 and @entity17 . We describe a case of primary @entity14 induced @entity13 in a 5-year-old @entity0 with @entity10 , microcephalia and mild @entity6 who, in the context of @entity5 , presented extreme @entity8 and prostration. Blood and urine tests showed high @entity9 phosphokinase concentrations and @entity16 . The @entity0 received aggressive intravenous hydration. Evolution was favorable with no @entity3 . @entity13 can produce life-threatening complications such as @entity3 , @entity12 and hyperkaliemia. The disease can be precipitated by @entity2 ingestion, compression injury and generalized @entity7 . Infectious etiology is less common. Few reports have been published on primary @entity14 induced @entity13 but, because @entity9 phosphokinase concentrations are not routinely performed in @entity5 , very mild cases might have been under-diagnosed. Despite its rarity, this disease should be considered in cases of @entity5 , since early treatment with hyperhydration can prevent complications.

title: [Varicella induced XXXX ].

answer: @entity13


abstract: More than half of the nursing home population is incontinent of urine or feces, presenting challenges to perineal skin health. To determine the occurrence and severity of @entity1 in nursing home residents with @entity2 , a secondary analysis of data collected from a multisite, open-label, quasi-experimental study of cost and efficacy of four regimens for preventing @entity2 -associated @entity4 in nursing home residents was performed. Sixteen randomly selected nursing homes from across the US were included in the study. Participating nursing home residents were @entity1 . Of the 1,918 @entity0 screened, 51% (n = 981) qualified for prospective surveillance. Perineal skin was assessed over a 6-week period; frequency, type, and severity of @entity1 were observed. Skin damage developed after a median of 13 (range 6 to 42) days in 45 out of 981 residents (4.6%), of which 3.4% was determined to be @entity2 -associated @entity4 . Some residents (14 out of 45, 31%) had @entity2 -associated @entity1 in more than one area. This study is one of the first to report the characteristics of @entity2 -associated @entity4 in a large sample of nursing home residents. The sample size and random selection of nursing homes impart generalizability to the findings. Incontinence-associated @entity4 is a risk in nursing home residents, especially those with @entity3 . These findings suggest that the rate and severity of @entity2 -associated @entity4 are low with close monitoring and use of a defined skin care regimen that includes a pH-balanced cleanser and moisture barrier.

title: Incontinence-associated XXXX in nursing home residents: a secondary analysis of a prospective, multicenter study.

answer: @entity1


abstract: STUDY OBJECTIVE: There is little evidence that cardiopulmonary resuscitation (CPR) alone may lead to the resuscitation of @entity2 victims with other than respiratory causes (eg, pediatric arrest, drowning, @entity3 ). The objective of this study was to identify out-of-hospital @entity2 or advanced cardiac life support. METHODS: This observational cohort included all adult survivors of out-of-hospital @entity2 of a cardiac cause from phases I and II of the Ontario Prehospital Advanced Life Support Study. During the study period, the system provided a basic life support/defibrillation level of care but no advanced life support. CPR-only @entity0 were @entity0 determined to be without vital signs by EMS personnel who regained a palpable pulse in the field with precordial thump or CPR only and then were admitted alive to the hospital. Six members of a 7-member expert review panel had to rate the @entity0 as either probably or definitely having an out-of-hospital @entity2 , and a rhythm strip consistent with a @entity2 had to be present to be considered a @entity0 . Criteria considered were witness status, citizen or first responder CPR, CPR duration, arrest rhythm and rate, and performance of precordial thump. RESULTS: From January 1, 1991, to June 30, 1997, 9,667 @entity0 with out-of-hospital @entity2 were treated. The overall survival rate to hospital discharge was 4.6%. There were 97 apparent CPR-only @entity0 admitted to the hospital. Application of the inclusion criteria yielded 24 CPR-only @entity0 who had true out-of-hospital @entity2 and 73 @entity0 judged not to have @entity2 . Of the 24 true CPR-only @entity0 admitted to the hospital, 15 @entity0 were discharged alive, 10 @entity0 were witnessed by bystanders, and 7 @entity0 were witnessed by EMS personnel. The initial arrest rhythm was pulseless electrical activity in 9 @entity0 , @entity2 in 12 @entity0 , and @entity1 in 3 @entity0 . One @entity0 with @entity1 converted to @entity4 with a single precordial thump. CONCLUSION: CPR-only survivors of true out-of-hospital @entity2 do exist; some victims of out-of-hospital @entity2 of primary cardiac cause can survive after provision of out-of-hospital basic life support care only. However, many @entity0 found to be pulseless by means of out-of-hospital evaluation likely did not have a true @entity2 . This has implications for the survival rates of most, if not all, previous @entity2 reports. Survival rates from @entity2 may actually be lower if one excludes survivors who never had a true arrest. The absence of vital signs by out-of-hospital assessment alone is not adequate to include @entity0 in research reports or quality evaluations for @entity2 .

title: CPR-only survivors of out-of-hospital @entity2 : implications for out-of-hospital care and XXXX research methodology.

answer: @entity2


abstract: UNASSIGNED: 1084 Background: @entity8 -associated @entity0 have pathologic features and biologic behavior that are distinct from @entity0 while @entity6 @entity2 are indistinguishable. Comparative survival studies have reported conflicting results and recent studies suggest relative resistance to @entity7 -based chemotherapy in @entity1 with @entity8 mutations. To determine if there are differences in long-term outcomes for @entity8 , @entity6 and high-risk non-carriers with @entity0 based on adjuvant therapy received, we conducted a retrospective analysis in US and Italian @entity1 . METHODS: @entity1 diagnosed with @entity0 between January 1, 1990 and December 31, 2008 were identified at the University of Chicago Cancer Risk Clinic and the Veneto Institute of Oncology in Padua. There were 80 @entity8 carriers, 78 @entity6 carriers and 177 high-risk non-carriers ascertained within the same time period. End points were @entity4 ( @entity4 ) and @entity4 ( @entity4 ) by type of adjuvant chemotherapy received. Hazard Ratios (HR) and 95% Confidence Intervals (95% CI) were calculated from Cox proportional hazard models. A multivariate analysis was used to adjust for year at diagnosis, stage, grade and @entity5 (ER) status. RESULTS: The median follow up was 4.98 (0.03-18.9). The @entity4 -adjusted hazard ratios were not significantly different among mutation carriers and non-carriers (HR among @entity8 carriers, 0.52; 95% CI, 0.21 to 1.31; HR among @entity6 carriers, 0.68; 95% CI, 0.31 to 1.48; P=0.326). The @entity4 -adjusted hazard ratios were not significantly different (HR among @entity8 carriers, 1.24; 95% CI, 0.45 to 3.45; HR among @entity6 carriers, 0.89; 95% CI, 0.33 to 2.38; P=0.837). Ten year survival was 78% for @entity8 , 83% for @entity6 and 92% for non-carriers, respectively. The risk of recurrence and @entity3 was also not statistically significant among @entity1 treated with different chemotherapy regimens. CONCLUSIONS: @entity4 and @entity4 survival are similar for carriers of a BRCA mutation and non-carriers.

title: Adjuvant chemotherapy in American and Italian @entity1 with @entity8 /2-associated XXXX .

answer: @entity0


abstract: BACKGROUND: @entity2 ( @entity3 ) is a major cause of morbidity. Rehabilitation for this population focus on strengthening the hip muscles, particularly the abductors, however the deficit in function of these muscles is unclear. OBJECTIVES: To review the evidence for the differences in structure and function of hip abductors (gluteus medius and minimus and @entity1 ) in hip @entity3 . METHODS: A systematic review was conducted using MEDLINE, AMED, CINAHL and SportDISCUS, from the earliest date to September 2013. Studies that compared hip @entity3 @entity0 with controls, or the unaffected contralateral hip were included. Studies needed to report data on an outcome related to gross gluteal muscle function. RESULTS: An initial yield of 141 studies was reduced to 22 after application of inclusion/exclusion criteria. Meta-analysis confirmed greater hip abductor strength in the control group (standardized mean difference = @entity4 -0.93, 95%CI -1.70 to -0.16) and the unaffected limb ( @entity4 -0.26, 95%CI -0.48 to -0.04). Meta-analyses showed no differences in muscle size either between groups or limbs. Few electromyography studies have been reported and meta-analysis was not possible. CONCLUSION: Hip abductor strength is reduced in @entity3 @entity0 compared to healthy controls and the unaffected limb. Data on muscle size and activity is insufficient.

title: Structure and function of the abductors in XXXX with @entity2 : Systematic review and meta-analysis.

answer: @entity0


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Spilanthes africana is a plant used in several countries for the treatment of toothache, @entity4 , @entity3 , @entity1 , and dysentery. In order to establish the safety of aerial part of the plant extract, the acute and sub-acute @entity2 of the aqueous extract of this plant has been evaluated in male and female young @entity0 . MATERIAL AND METHODS: In acute @entity2 , the effects of a single oral dose (2000mg/kg and 5000mg/kg) of the lyophilised aqueous extract have been determined. General behaviour, adverse effects and mortality were determined for up to 14 days. In sub-acute treatment, the effects of the extract in daily single oral administration at the doses of 250, 500 and 1000mg/kg during 28 days were evaluated. One group treated at the dose of 1000mg/kg for 28 days was let without treatment during 14 days to assess the possible reversibility of the harmful effects of the extract. Body weight, food and water intakes, biochemical and haematological parameters were recorded. Histopathological examination of liver, kidney and lungs were assessed. RESULTS: In acute study, a single administration of the aqueous extract at the doses of 2000mg/kg or 5000mg/kg did not induce mortality. Thus, the LD50 of the aqueous extract of @entity10 has been estimated higher than 5000mg/kg. Four hours after administration of the extract, a reduction of the mobility, sensitivity to the noise and to touch has been observed. In sub-acute study, the administration of the extract during 28 days at all doses did not significantly modify the body weight. On the haematological analysis, a decrease of the rate of monocytes and a rise of lymphocytes counts were observed among the male group. In both sexes, it appeared a decrease of the rate of granulocytes two weeks after stopping the treatment. It has also been observed in different groups among the females, an increase of the mean corpuscular content and the mean concentration in haemoglobin as well as an increase of platelets. A significant decrease of transaminases, alkaline phosphatase, @entity7 , and a significant increase of total @entity5 compared to the normal group has been observed. There was a significant decrease in renal @entity9 in both sexes compared with different control groups. Besides, a significant increase of the kidney rates of @entity8 and @entity6 have also been observed in the female treated at the doses of 1000mg/kg. Histopathological analysis has shown vascular congestion and leucocyte infiltrations in the liver of animals treated at the dose of 1000mg/kg. This congestion has been marked in satellite group. In the kidney female satellite group, tubular clarifications have been observed and disappear when stopping the treatment. CONCLUSION: These results show that the aqueous extract of @entity10 given by the oral route is slightly toxic. However in sub-acute treatment, higher doses could provoke functional and structural changes in the organism which could in part reversible. Thus the extract should be used with caution.

title: Acute and sub-acute XXXX of a lyophilised aqueous extract of the aerial part of Spilanthes africana Delile in @entity0 .

answer: @entity2


abstract: Impairment of @entity1 (NO) production, @entity4 receptor (RyR) @entity0 channel function and adrenoceptor activation have been found to prevent the formation of the long-term memory stage in young chicks trained on a single-trial discrimination avoidance task. The current study investigated whether these three activities were linked, and if so, the sequence of activation. Young chicks were trained using either a strongly or weakly reinforced variant of the single-trial discrimination avoidance task, yielding either a persistent or labile memory trace, respectively. Following strongly reinforced training, @entity3 induced by a RyR inhibitor was prevented by a NO donor or @entity2 (NA). A RyR agonist also prevented @entity3 induced by either NO synthase or b1+2-adrenoceptor inhibition. These findings were interpreted to reflect the capacity of NO, RyR-dependent @entity0 release and NA to modulate memory by preventing @entity3 . A second set of studies used weakly reinforced training. Although the administration of a RyR agonist promoted long-term memory formation, this facilitation was compromised in the presence of a b1+2-adrenoceptor antagonist, but not a NO synthase inhibitor. Similarly, the inhibition of RyRs interfered with the facilitation of retention induced by a NO donor, but not NA. These differential findings with weakly reinforced training suggest that NO facilitates memory formation through mechanisms involving RyR-dependent @entity0 release. The findings also indicate that RyRs may promote memory formation through noradrenergic activation of b2-adrenoceptors. This study demonstrates an intricate role for RyRs underlying memory formation.

title: Pharmacobehavioural evidence for @entity1 and @entity2 interactions with XXXX receptors during memory formation in the young chick.

answer: @entity4


abstract: STUDY DESIGN: Case series. PURPOSE: The objective of this study was to investigate the change in pulmonary function in adult @entity0 with a @entity2 who underwent spinal corrective surgery. OVERVIEW OF LITERATURE: @entity3 are is often prominent in adult @entity2 cases, whereas a @entity2 involving the chest wall is inconspicuous. @entity2 could affect the pulmonary function; however, few reports have investigated pulmonary function in adult @entity0 with a @entity2 . METHODS: This study included 14 adult @entity0 with a @entity2 who underwent posterior corrective fusion (3 males, 11 females; mean age, 67.4 years). We measured percent vital capacity (%VC) and percent forced expiratory volume in 1 second (%FEV1) before surgery and six months after surgery. We investigated the change in pulmonary function after corrective surgery and the correlation between radiographic parameters and pulmonary function. RESULTS: Mean preoperative %VC and %FEV1 values were 99.9% and 79.3%, respectively. Two cases were diagnosed with @entity1 , and two cases were diagnosed with @entity1 before surgery. %VC improved in the @entity1 cases six months after surgery. However, %FEV1 did not improve significantly after surgery in the @entity1 cases. CONCLUSIONS: Restrictive impairment was improved in adult @entity0 with a @entity2 by corrective spinal surgery. However, spinal surgery did not improve @entity1 .

title: Preoperative and Postoperative Pulmonary Function in Elderly XXXX with Thoracolumbar Kyphoscoliosis.

answer: @entity0


abstract: In @entity1 , the diminished HLA-DR expression on monocytes has been proposed as a marker of immunoparalysis that correlates with an increased risk for fatal outcome. The present study was designed to determine whether some differences in protocol procedures could lead to discrepant results in HLA-DR measurement. After establishing a reliable protocol, the second objective was to illustrate the immunoparalysis in @entity0 with @entity1 . HLA-DR measurement on monocytes was determined by means of flow cytometry in 54 healthy donors and 16 @entity0 with @entity1 . We demonstrated that storage temperature, storage duration before staining and red cells lysis constitute crucial steps in HLA-DR measurement. The precision results with coefficients of variation below 5%, were quite convincing for a manual immunoassay. At 48 hours after diagnosis of @entity1 , we found severely decreased percentages of monocytes expressing HLA-DR in septic @entity0 (24 +/- 4%, mean +/- SEM) in comparison with healthy donors (90 +/- 1%), p < 0.001). Furthermore, the persistence of a low level of monocytic HLA-DR (less than 50 %) at day 9 after admittance was associated with @entity0 who died. This study illustrates the state of immunoparalysis in @entity0 with @entity1 and supports the potential interest in measuring HLA-DR expression on monocytes. However, multicenter studies are now needed to validate this parameter. Based on our analytical results, we conclude that a critical issue in such studies will be the capacity in each center to perform standardized measurement of HLA-DR. It should be remembered that this determination requires the definition of a common analytical procedure between laboratories participating in the trial.

title: [Preliminary results in standardization of flow cytometry protocols for monocytic HLA-DR measurement and their application in the follow up of XXXX ].

answer: @entity1


abstract: OBJECTIVES: To explore the relationship between @entity2 ( @entity2 ) and resistant @entity3 in @entity6 ( @entity6 ) and @entity5 ( @entity5 ). METHODS: We examined sleep parameters and blood pressure (BP) in 224 community-based, non- @entity6 @entity0 from the Sleep-SCORE study: 88 nondialysis-dependent @entity6 and 95 @entity5 @entity0 . Unattended home polysomnography with standardized scoring protocols and automated BP monitors were used. Resistant @entity3 was defined as a BP of at least 140/90 mmHg despite at least three antihypertensive drugs. RESULTS: Mean SBP of the @entity6 and @entity5 groups were significantly higher than that of the non- @entity6 group [148.2 (23.8), 144.5 (26.7) vs. 132.2 mmHg (26.7), respectively; P<0.0001] despite the use of more antihypertensive medications. The @entity6 and @entity5 groups had higher rates of resistant @entity3 than the non- @entity6 group (41.4, 22.6 vs. 6.7%, respectively; P<0.0001). The severity of @entity4 was associated with a higher risk of resistant @entity3 . Although resistant @entity3 was associated with severe @entity4 in @entity0 with @entity5 [ @entity8 , 95% confidence interval (CI) 2.2-23.2), there was no significant association in the non- @entity6 (OR 3.5, 95% CI 0.8-15.4) or @entity6 groups (OR 1.2, 95% CI 0.4-3.7) after accounting for case-mix. CONCLUSION: The association between resistant @entity3 and @entity4 appeared robust in @entity5 . @entity2 may contribute to resistant @entity3 or both may be linked to a common underlying process such as @entity7 . Future studies in @entity0 with @entity1 should further characterize the resistant @entity3 - @entity2 relationship and determine whether treatment of underlying mechanisms may improve outcomes.

title: Resistant @entity3 and @entity2 in the setting of XXXX .

answer: @entity1


abstract: In this study we evaluated treatment effects in 70 consecutively admitted @entity0 in a specialized university clinic for treatment of dental fear. Thirty-three (47%) of the @entity0 fulfilled the diagnostic criteria for Specific @entity2 alone (Dental @entity2 , DP), 24 (33%) had severe dental @entity1 without fulfilling the criteria for @entity2 ( @entity3 ), and 13 (19%) fulfilled the criteria for @entity4 ( @entity4 ). Dental @entity1 was measured prior to, immediately after and at follow-up (mean = 19 months) using Corah's Dental @entity1 Scale and Dental Fear Survey. Dental attitudes were measured by Getz' Dental Beliefs Survey. Dental attendance and everyday functioning were measured by self-report. DP @entity0 received significantly more treatment-sessions as compared to the @entity3 group. Despite significant overall reductions in scores on all psychometric instruments from pretreatment to follow up, @entity0 in the @entity4 group reported significantly more severe @entity1 at pre- and post-treatment and at follow-up as compared to @entity0 in the @entity3 group. There was no interaction between diagnostic group and assessment occasion (pre treatment, post treatment and follow up) on the self-reported @entity1 . @entity0 reported significant improvements in self-esteem, social relations and everyday functioning, regardless of diagnostic group. Sixty-three percentage of the respondents had been to the dentist within 1 year after completed treatment. @entity0 treated by dentists who had received supervised training in exposure treatment had significantly more often seen the dentist at follow-up.

title: Treatment of XXXX . Outcome related to DSM-IV diagnoses.

answer: @entity1


abstract: PURPOSE: We performed this study to evaluate factors related to urinary retention after a tension-free vaginal tape (TVT) procedure for female stress urinary @entity1 . MATERIALS AND METHODS: We retrospectively analyzed the records of 375 @entity0 with a followup of at least 6 months from among @entity0 who underwent the TVT procedure between March 1999 and May 2002 at our institution. We analyzed multiple parameters, including @entity0 characteristics, symptoms and urodynamic studies, using univariate and multivariate regression analyses with respect to postoperative urinary retention, as defined by the need for intermittent catheterization for at least 3 days after the procedure. All @entity0 in the nonretention (343) and retention (32) groups answered a global satisfaction question. RESULTS: In answer to a global satisfaction question 338 of the 375 @entity0 (90.1%) favored the procedure. Univariate analysis demonstrated that @entity0 mean age, parity, peak urinary flow and a history of hysterectomy predicted urinary retention. However, on multivariate analyses the peak urinary flow rate was the only significant independent predictive factor (p = 0.007). While 28 @entity0 (87.5%) in the retention group regained normal voiding without a specific procedure, 4 required tape release or cutting within 3 month of surgery. The global satisfaction question showed a significant difference between the nonretention and retention groups (91.5% vs 75% satisfaction, p = 0.03). CONCLUSIONS: An accurate measurement of the peak urinary flow rate could predict @entity0 at risk for postoperative urinary retention that compromises global satisfaction after the highly curative TVT procedure.

title: Factors predictive of urinary retention after a tension-free vaginal tape procedure for female stress urinary XXXX .

answer: @entity1


abstract: BACKGROUND: Mortality in @entity5 @entity1 both from natural and non-natural causes was reported to be markedly higher than in the general population. The effect of the @entity5 hospital (PH) closure process on mortality has nonetheless seldom been investigated. We studied mortality in a cohort of PH @entity1 , taking into account the closure process in Italy. METHODS: A total of 2915 @entity1 from 12 PH were described in the period 1994-1996 and followed up until June 2000, and discharges and @entity6 were registered. Standardized mortality ratios (SMR) for natural and non-natural causes were computed on the basis of regional death rates. RESULTS: Observed @entity6 were 714 vs. 291.2 expected. The all-causes SMR was 2.47 in males and 2.43 in females. The SMR was 26.92 in males and 13.75 in females for @entity5 causes, 6.84 and 7.89 for undefined causes, 9.57 and 7.27 for @entity4 , 6.38 and 7.78 for @entity8 , and 1.27 and 1.58 for @entity7 . No excess was observed for all @entity3 in males, but the SMR was 1.50 for @entity2 in males, 2.30 for @entity0 and 1.48 for all @entity3 in females. SMR for suicide was 3.85 in males and 2.73 in females. Most SMR were higher at younger age, although the rate of absolute excess @entity6 was greater above age 60. The SMR for all causes was 2.66 before discharge from PH, and 2.09 after discharge. CONCLUSIONS: Mortality remained high after leaving the PH, but no increase was associated to the PH closure.

title: Mortality in long-stay XXXX from @entity5 hospitals in Italy--results from the Qualyop Project.

answer: @entity1


abstract: UNASSIGNED: Bacteria cope with and adapt to stress by modulating gene expression in response to specific environmental cues. In this study the transcriptional response of @entity2 to osmotic, oxidative, and @entity0 stress conditions at two time points was investigated via identification of differentially expressed mRNAs and sRNAs. A total of 440 small RNA transcripts were detected, where 10% correspond to previously annotated sRNAs, 40% to novel intergenic transcripts and 50% to novel transcripts antisense to annotated genes. Each stress elicits a unique response as far as the extent and dynamics of the transcriptional changes. Nearly 200 protein-encoding genes exhibited significant changes in all stress types, implicating their participation in a general stress response. Almost half of the sRNA transcripts were differentially expressed in at least one condition, suggesting possible functional roles in the cellular response to stress conditions. The data show a higher fraction of differentially expressed sRNAs with greater than 5-fold expression changes compared with mRNAs. The work provides detailed insights into the mechanisms through which @entity1 responds to different stress conditions and increases understanding of bacterial adaptation in natural and industrial settings. IMPORTANCE: This study maps the complete transcriptional response of @entity2 to osmotic, oxidative and @entity0 stress conditions at short and long exposure times. Over 400 small RNA transcripts are detected, consisting of both intergenic and antisense transcripts, increasing the number of identified sRNA transcripts in the strain by a factor of ten. Unique responses to each type of stress are documented including both the extent and dynamics of the gene expression changes. The work adds rich detail to previous knowledge of stress response mechanisms due to the depth of the RNA sequencing data. Almost half of the sRNAs exhibit significant expression changes in at least one condition, suggesting their involvement in adaptation to stress conditions and identifying interesting candidates for further functional characterization.

title: Global transcriptional responses to osmotic, oxidative, and @entity0 stress conditions in XXXX .

answer: @entity1


abstract: BACKGROUND: Partial tetrasomy is mainly described as a cytogenetically visible rearrangement due to a supernumerary chromosome (i(12p), i(18p), @entity6 dup(15)). Except for chromosome 15q11q13, intrachromosomal triplications are rare and so far not associated with a recognisable phenotype. METHODS AND RESULTS: This report describes two unrelated @entity0 with a de novo non-recurrent submicroscopic interstitial triplication 11q24.1 detected with array comparative genomic hybridisation and confirmed by fluorescence in situ hybridisation, molecular combing, and quantitative PCR. Microsatellite analysis suggested that a common mechanism of rearrangement might have been involved. These @entity0 share remarkably similar clinical features including distinctive @entity2 , @entity4 with small extremities, @entity5 , overweight, and @entity3 . The overlapping region of 1.8 Mb contains 11 RefSeq genes and three microRNA related genes. Interestingly, the overexpression of @entity7 , a gene encoding an adipocyte specific adhesion molecule, may contribute to @entity0 ' @entity1 . Upregulation of BILD, known to mediate apoptosis in a caspase dependent manner, could deserve further investigation into the pathological mechanism of @entity5 . CONCLUSION: Isolated duplications of distal 11q region have been previously reported and associated with @entity3 but without a consistent set of clinical features. These findings support the proposal that microtriplication 11q24.1 is a well recognisable clinical entity.

title: Microtriplication of 11q24.1: a highly recognisable phenotype with @entity4 , distinctive facial features, @entity5 , overweight, and XXXX .

answer: @entity3


abstract: The presence of @entity5 dehydrogenase (11beta-HSD; EC1.1.1.146), the enzyme responsible for the interconversion of @entity2 and @entity3 , in granulosa- @entity4 (GL) cells is associated with a poor outcome in @entity1 ( @entity1 ). We have developed a simple method of assessing the reductase component of 11beta-HSD in these cells which is sufficiently rapid to provide data on the enzyme's activity prior to embryo replacement. Cells were pooled from follicular aspirates and challenged with @entity3 within 2 h of aspiration. @entity2 secretion was then measured by radioimmunoassay. Conversion of @entity3 to @entity2 was linear for up to 3 h and was completely inhibited by @entity6 , a specific 11beta-HSD inhibitor. Initial velocity rates were determined for eight @entity3 concentrations (range 0.1-8 micromol/l), and the apparent Km calculated (1.6 +/- 0.4 micromol/l). There was no evidence of substrate/product inhibition and conversion of @entity3 to @entity2 was <2% in all experiments. In subsequent work, cells were challenged with @entity3 (6 micromol/l) for 2 h. Cells challenged for 2 h immediately following purification from follicular aspirates produced varying amounts of @entity2 (range 25-150 nmol/pooled follicles from each @entity0 , n = 10 @entity0 ), while basal outputs were <6 nmol/l. Enzyme activity was also examined in cells on a per follicle basis from individual @entity0 and found to vary considerably (e.g. 19, 53 and 36 nmol/l @entity2 /1000 cells, three follicles). Having established the method for assessing 11beta-reductase activity within GL cells, we performed a small prospective study on a series of 20 @entity0 examining the enzyme activity within 110 individual follicles. 11Beta-reductase activity varied greatly from @entity0 to @entity0 and from follicle to follicle ranging from <0.024-0.57 nmol @entity2 /microg DNA but at present low @entity0 numbers preclude a meaningful correlation between enzyme activity and pregnancy rate. In summary, we have developed a simple, rapid (<8 h) assay for detecting the reductase activity of 11beta-HSD in GL cells isolated from pooled or individual follicles. This procedure is sufficiently quick to aid in the choice of embryo for replacement.

title: A rapid method for the measurement of the oxoreductase activity of @entity5 dehydrogenase in granulosa-lutein cells from XXXX undergoing @entity1 .

answer: @entity0


abstract: OBJECTIVES: We aim to illustrate the multimodal imaging spectrum of hepatic involvement in @entity5 ( @entity5 ). Whilst disseminated @entity5 on imaging typically manifests as @entity2 scattered in the liver parenchyma, isolated @entity10 remains a rare and intriguing entity. METHODS: Indubitably, imaging is the mainstay for detection of tubercular @entity3 which display a broad spectrum of imaging manifestations on different modalities. While sonography and computed tomography (CT) findings have been described in some detail, there is a paucity of literature on magnetic resonance imaging (MRI) features. Due to a significant overlap with other commoner and similar appearing @entity3 , @entity10 is often either misdiagnosed or labelled as indeterminate lesions. This article is a compendium of cases highlighting the spectrum of imaging patterns that can be encountered in @entity0 with isolated primary @entity10 as well as disseminated (secondary) disease. Rare patterns of @entity1 such as tubercular @entity4 , @entity6 , and those with @entity7 are also illustrated and discussed. CONCLUSIONS: Imaging plays a valuable role in the detection of tubercular @entity3 . Also, imaging can be helpful in their characterisation and for assessing associated complications. TEACHING POINTS:     Hepatic @entity5 has myriad imaging manifestations and is often confounded with @entity8 .     Imaging patterns include @entity9 , macronodular @entity5 , serohepatic @entity5 and tubercular @entity4 .     Concurrent splenic, nodal or pulmonary involvements are helpful pointers towards the diagnosis.     Miliary calcifications along the bile ducts are characteristic of tubercular @entity4 .     Histological/microbiological confirmation is often necessary to confirm the diagnosis.

title: XXXX : a multimodality imaging review.

answer: @entity10


abstract: BACKGROUND: @entity3 located between the 2 middle cerebral artery (MCA) bifurcations may be approachable through a single unilateral approach. OBJECTIVE: To identify anatomic parameters based on imaging that would favor a contralateral approach. METHODS: From January 1998 to December 2013, we retrospectively identified 173 @entity0 with bilateral @entity2 . Fifty-one @entity0 had @entity2 . A total of 38 @entity0 underwent a single craniotomy with a contralateral microsurgical approach (group 1 or contralateral group) and 13 @entity0 underwent bilateral craniotomies (group 2 or bilateral group). For both groups, we analyzed @entity3 characteristics, morphology, size, projections, and distance to the contralateral corridor, as well as surgical time, outcome, and @entity1 . RESULTS: All @entity3 approached contralaterally were unruptured and without wall calcifications. Of the contralaterally approached @entity3 , 97% were smaller than 14 mm. The median length of the contralateral A1 was 13.2 mm (range: 6-19.8 mm) and the median length of the contralateral M1 was 14.2 mm (range: 4.6-21 mm). The contralateral group had a good postoperative outcome (modified Rankin Scale 0-3) in 80% of ruptured cases and 86% of unruptured cases. The median surgical time was 120 minutes (range: 75-255 minutes), 43% shorter than the bilateral group. CONCLUSION: The contralateral approach for @entity2 in selected @entity0 is feasible in experienced hands, with acceptable morbidity and mortality. The contralateral approach requires a meticulous preoperative analysis of the characteristics of the @entity3 to be clipped and of the anatomic constraints of the microsurgical operative corridor. ABBREVIATIONS: A1, anterior cerebral artery proximal segmentbMCA, bilateral middle cerebral arteryCTA, computed tomographic angiographyHH, Hunt-Hess scaleIA, @entity5 , internal carotid arteryICAbif, internal carotid artery bifurcationMCA, middle cerebral arteryM1, middle cerebral artery proximal segmentmRS, modified Rankin ScaleSAH, @entity4 .

title: Contralateral Approach to XXXX : Comparative Study, Angiographic Analysis, and Surgical Results.

answer: @entity2


abstract: @entity2 commonly arise in the central nervous system. Extraneural presentation is quite rare. Herein, we describe a primary @entity2 in a young female. The mass was located in the right inguinal area. The cut surface of the 7.5 mm * 6.5 mm * 4.5 mm sized @entity0 was brownish-yellow in color. Histologically, it was hypercellular exhibiting pseudorosette or rosette formations and some papillary structures. Mitosis was counted as high as 10 per 10 high power fields. Neither @entity1 nor vascular endothelial proliferation within the @entity0 was observed. @entity0 cells showed strong glial fibrillary acidic protein immunoreactivity. On epithelial membrane antigen, intracytoplasmic dot-like immunostaining was observed. This is the first report presenting a primary extraneural @entity2 arising in the inguinal subcutaneous region.

title: An extraneural primary XXXX at the subcutaneous inguinal region: Report of a rare case.

answer: @entity2


abstract: @entity3 ( @entity3 ) is a @entity5 characterized by the presence of an acquired mutation which affects the hematopoietic stem cell, leading to a striking overproduction of immature granulocytes. The first important clue to its pathogenesis the @entity6 chromosome created by a reciprocal translocation between chromosomes 9 and 22 (t [9; 22] [q34; q11]). The development of the @entity4 -targeted imatinib mesylate represents a paradigm shift in the treatment of @entity3 . Imatinib displays inhibitory activity against other kinase(s) that play a role in monocyte/macrophage development. Accordingly many studies revealed the role of cytokines in pathophysiology of myeloid @entity1 including participation of @entity2 in the pathogenesis of @entity3 . This study designed to assess the behavior of @entity2 through newly diagnosed @entity0 , different responders groups (optimal, suboptimal and failure cytogenetic response) and advanced stages (acceleration and crisis groups) of @entity3 Iraqi @entity0 whom receiving Imatinib mesylate (tyrosine kinase inhibitor), trying to elucidate the role of immunity in pathophysiology of @entity3 development and treatments. In this study 96 Iraqi @entity3 @entity0 under imatinib mesylate treatment categorized by complete blood picture and fluorescent in situ hybridization analysis into different response groups and stages, then used an enzyme linked immunosorbent assay technique to assess serum level of @entity2 in each response group and advance stage (acceleration and transformed) of @entity3 @entity0 , in comparison to level in 32 healthy control subjects and 32 newly diagnosed @entity3 . Out of 128 @entity0 the mean serum of @entity2 level (pg/ml) for the newly diagnosed, optimal responded, suboptimal responded, failure cytogenetic and advance stage of @entity3 were 6.53      3.81, 18.47      4.29, 18.69      3.03, 5.73      2.44, and 18.10      3.10, respectively. While healthy was 12.17      3.44. The measurement of @entity2 before and during treatment of @entity3 @entity0 may contribute to the early identification of responder and non responder @entity0 , and help in the earlier choice and/or design of alternative therapeutic strategies.

title: Assessment of XXXX serum level in different responder groups and stages of chronic myeloid leukemia @entity0 on imatinb mesylate therapy.

answer: @entity2


abstract: INTRODUCTION: The third Brazilian Consensus of @entity1 recomends the usage of pharmacological (PT) and non-pharmacological treatment (NPT). In Brazil, we don't know how if this recommedation has been followet by doctors. OBJECTIVES: a) to characterize NPT regarding prescription and acceptability by @entity1 @entity0 ; b) characterize PT concerning the criterion used for choosing medication and medication prescribed; and c) identify doctors' opinions about @entity0 ' degree of acceptability to PT and NPT. METHODS: 37904 questionnaires with reply-paid envelopes were sent to Brazilian doctors and 2519 of those were replied (57% from the Southeast region, 41% were cardiologists, and 26% clinicians). RESULTS: 1- 62% of doctors recommend NPT to 25% of their @entity0 . 2 - The most recommended NP treatments are: hyposodic diet (55%), @entity2 (29%) and physical exercises (8%), considering that doctors believe that 50% of their @entity0 follow a hyposodic diet, 20% do physical exercises and 19% lose weight. 3 - Only one medication is prescribed at the beginning of a PT (88%) and when blood pressure isn't under control, 55% of the doctors associate other medications with it whereas 33% of them increase the dose. 4 - The most prescribed medications are: diuretics (53%) and ECA inhibitors (24%). 5 - The main criteria for choosing medication are: personal experience (32%) and characteristics of @entity0 (31%). 6 - Doctors (60%) believe that acceptability to PT is better. CONCLUSION: The recommendations of the Third Brazilian Consensus of @entity1 have been followed partially concerning NPT and as expected regarding PT.

title: [Treatment of XXXX - answers of Brazilian physicians to a survey].

answer: @entity1


abstract: Bevacizumab is FDA-approved for @entity0 with recurrent GBM. However, the median duration of response is only 4  months. Potential mechanisms of resistance include upregulated FGF signaling and increased PDGF-mediated pericyte coverage. @entity5 is an oral, small-molecule @entity2 kinase inhibitor of @entity3 /b, FGFR 1-3, and @entity4 -3 that may overcome resistance to anti-VEGF therapy. This was a two-stage phase II trial in adults with first or second recurrence of GBM, stratified by prior bevacizumab therapy (ClinicalTrials.gov number NCT01380782; 1199.94). The primary endpoint was PFS6 in the bevacizumab-naive arm (Arm A) and PFS3 in the post-bevacizumab arm (Arm B). Up to 10 @entity1 ( @entity1 ) @entity0 were accrued to each arm in exploratory cohorts. Twenty-two @entity0 enrolled in Arm A and 14 in Arm B. Arm A included 12 GBMs (55  %), 13 @entity0 with one prior regimen (59  %), and median age 54  years (range 28-75). Arm B included 10 GBMs (71  %), one @entity0 with one prior regimen (7  %), and median age 52  years (range 32-70). Median KPS overall was 90 (range 60-100). There were no responses. In Arm A (GBM only), PFS6 was 0  %, median PFS 28  days (95  % CI 27-83), and median OS 6.9  months (3.7-8.1). In Arm B (GBM only), PFS3 was 0  %, median PFS 28  days (22-28), and median OS 2.6  months (1.0-6.9). Among @entity1 @entity0 in each arm, PFS6 was 0  %. Treatment was well tolerated. In conclusion, @entity5 is not active against recurrent high-grade @entity1 , regardless of prior bevacizumab therapy.

title: Phase II trial of triple @entity2 kinase receptor inhibitor @entity5 in recurrent high-grade XXXX .

answer: @entity1


abstract: UNASSIGNED: Abstract Background: Combined physical therapy (CPT) is the treatment of choice for @entity0 with @entity2 . Intensive stage CPT (I-CPT) results in a substantial reduction of the size of @entity2 , while the second stage CPT (M-CPT) maintains the achieved result for many years. Aim: The article analyses the outcome M-CPT for 5 years in @entity0 with @entity2 after mastectomy. Methods: Forty @entity0 had regularly been attending follow-up appointments every six months for five years (Group A). Out of the group of @entity0 who had not been reporting for follow-up, twenty @entity0 accepted an invitation for assessment (Group B); none of them complied with the prescribed compression therapy. All @entity0 were submitted to I-CPT and @entity0 from group A completed M-CPT comprising compression garments and an individual program of physical exercises. Results: During five-year M-CPT, the difference in limb volumes (Vo), relative size of @entity1 (Vor) reduction achieved after I-CPT was maintained in Group A, while in Group B a considerable increase of Vo by 14% was noted. Ultimately @entity2 in these @entity0 was more pronounced than before their physical therapy had commenced. For 40 @entity0 using compression sleeves the mean Suitability Score System was 8.3 points on maximum 11-point scale, for 15 @entity0 wearing additional compression gloves, the mean score was 4.3 points on maximum 5 points. Conclusions: The reduction of @entity2 achieved during I-CPT can be retained during M-CPT when the @entity0 systematically attends follow-up examinations, applies compression therapy, and follows the therapy instructions. Non-compliance is followed by a worsening of @entity2 .

title: Five-Year Assessment of Maintenance Combined Physical Therapy in XXXX .

answer: @entity2


abstract: RATIONALE: @entity1 ( @entity1 ) is associated with increased risk of @entity4 . Continuous positive airway pressure (CPAP) delivered via a nasal mask during sleep immediately alleviates obstructive @entity8 and improves sleep quality and daytime somnolence. However, there is uncertainty as to whether such treatment can modify CV risk and disease. AIMS: The Sleep @entity4 Endpoints (SAVE) study aims to determine whether CPAP on top of best medical care compared to best medical care alone can reduce the risk of serious CV events in @entity0 with co-morbid @entity1 and established @entity5 . DESIGN: SAVE is an investigator initiated and conducted, international, multicenter, open, blinded endpoint, randomized controlled trial. @entity0 were randomised to either CPAP or usual care between 2008 and 2013 and will be followed up for an average of approximately 4 years. STUDY OUTCOME: The primary endpoint is a composite of @entity6 , @entity9 ( @entity9 , including @entity9 ), @entity3 , hospitalisation for @entity10 , hospitalisation for an acute @entity2 @entity7 ( @entity11 ) or cerebral event (transient @entity2 event [TIA]). DISCUSSION: The pre-specified statistical analysis plan (SAP) for the main analyses is presented. This SAP was finalised before @entity0 follow-up was completed and before any unblinding of the data. The SAP outlines details of the primary, secondary and tertiary outcomes, together with planned subgroup and exploratory analyses.

title: Statistical analysis plan for the Sleep XXXX Endpoints study: An international randomised controlled trial to determine whether continuous positive airways pressure treatment for @entity1 in @entity0 with @entity5 prevents secondary cardiovascular events.

answer: @entity4


abstract: INTRODUCTION: @entity6 showed activity in 50 @entity7 @entity0 treated within a Phase II study. In that study, 70% of @entity0 remained with @entity2 ( @entity2 ), median progression free survival (PFS) was 9 months and median @entity5 ( @entity5 ) was 34 months. We now report on a retrospective series of @entity9 / @entity8 positive advanced @entity7 @entity0 treated with @entity6 as a single agent within a compassionate-use programme at Istituto Nazionale Tumori, Milan, Italy (INT) between August 2002 and November 2010, when the programme was closed. METHODS: 48 @entity0 were consecutively treated with @entity6 800 mg/d. All @entity0 had inoperable and progressive disease before starting @entity6 . Demographics, treatment duration, @entity4 and response rate by Response Evaluation Criteria in @entity1 (RECIST) were retrospectively recorded. RESULTS: The median duration of therapy was 7 months (1-46.5). No @entity0 is on therapy at present. 46 @entity0 were evaluable for response. No partial responses were detected. Best response was: @entity2 34 (74%), @entity3 (26%). At a median follow-up of 24.5 months (0.5-117), median PFS was 9.9 months (95% confidence interval (CI) 6.7-13). Eight @entity0 (16.5%) remained on therapy >18 months and 10 @entity0 (21%) remained progression-free >18 months. Median @entity5 was 30 months (95% CI 20-40), with 24 (50%) @entity0 dead at the time of the present analysis. CONCLUSIONS: We confirm the activity of @entity6 in locally advanced and metastatic @entity7 , in terms of >70% @entity1 growth arrest in previously progressive @entity0 . Median duration of response lasted almost 10 months, with >20% of @entity0 progression-free at 18+ months.

title: XXXX in advanced @entity7 : A retrospective case series analysis.

answer: @entity6


abstract: UNASSIGNED: The aim of the study was to present first preliminary characterization of Turkish hospital wastewaters, their environmental risk, and a method for @entity0 assessment. The hospital wastewater samples were collected from two of the largest medical faculty hospitals and a training and research hospital in Istanbul, @entity2 . The samples from the selected hospitals were taken as grab samples on March 2014. Overall, 55 substances including pharmaceuticals and their metabolites, pesticides, and corrosion inhibitors were analyzed in all hospital wastewaters. Analysis of @entity0 and the antibiotic resistance bacteria were investigated in addition to the chemical analysis in the wastewater of one hospital. Hazard quotients (HQs) and toxic units (TUs) were calculated as basis of the environmental risk assessment. Fourteen pharmaceuticals in hospital wastewater (HWW) were classified as "high risk" with HQ  >  10. HQHWW values higher than 100 were determined for five antibiotics and one analgesic, namely, @entity3 , @entity6 , @entity4 , @entity8 , @entity1 , and @entity5 . @entity3 with an HQHWW of 9090 was observed to be the most hazardous compound. HQ and TU values of the wastewater treatment plant (WWTP) effluent dropped significantly due to dilution in the sewer. Further elimination by biological degradation or adsorption was observed only in some cases. However, the decreased HQWWTPeffluent values do not the change environmental load significantly. Therefore, advanced treatment processes should be applied to remove the persistent compounds. In combination with the results on antibiotic resistance, we would prefer on-site treatment of hospital wastewater. Toxicological assessment was performed using cytotoxic and mutagenic screening tests. The results of the Ames assay showed that the native hospital wastewaters had strongly mutagenic activity with a <= 10-fold increase relative to negative controls. The mutagenic potentials of the samples were generally concentration and metabolic activation dependent. Multiple antibiotic resistances were demonstrated with the tested isolates to @entity4 , @entity1 , and @entity7 . This study demonstrates that the hospital wastewaters in Istanbul exhibit strong environmental and toxicological risks, as well as high multiple drug resistance to commonly used antibiotics.

title: Characterization and XXXX of hospital wastewaters in @entity2 .

answer: @entity0


abstract: PURPOSE OF REVIEW: Simultaneous transfer of multiple embryos in an assisted reproductive technology (ART) cycle results in a high rate of multiple pregnancy. Besides the medical complications associated with multiple pregnancy, the financial burden of the resultant preterm @entity0 is also substantial. The current review evaluates the costs associated with the care of preterm @entity0 that are born as a result of ART-associated @entity1 . RECENT FINDINGS: In 2006, 30% of all ART live births were multiple @entity0 deliveries in the USA. This resulted in 48% of all ART neonates being the product of a multiple @entity0 delivery. In the same year, 62% of ART twins and 97% of ART triplets were delivered preterm, corresponding to approximately 17 000 @entity0 . The Board of Health Sciences Policy has estimated the mean cost of each preterm @entity0 to be US  51 600. Therefore, the financial burden of ART-associated preterm deliveries is estimated to be approximately US  1 billion annually. This figure has remained essentially unchanged between 2001 and 2006, despite decreasing number of embryos transferred, due to increasing total number of ART cycles performed. SUMMARY: Preterm deliveries that result from ART-associated @entity1 add a substantial burden to overall US healthcare expenditure annually. Policies limiting the number of embryos transferred should be considered with a perspective to increase elective single embryo transfers.

title: Preterm deliveries that result from XXXX associated with assisted reproductive technologies in the USA: a cost analysis.

answer: @entity1


abstract: BACKGROUND: About 17% of all @entity0 suffer from a @entity1 in early childhood, defined as the period up to the age of 6 years. METHODS: This review is based on publications retrieved by a selective search in PubMed and the Web of Science, as well as on the authors' clinical and scientific experience. RESULTS: In @entity0 up to age 2, @entity5 are common (ca. 7%), as are feeding problems (25%), which persist in 2% of @entity0 to meet the diagnostic criteria for a feeding disorder. @entity7 , a serious @entity4 , has a prevalence of about 1%: it is more common among @entity0 in situations of increased risk, e.g., orphanages and foster homes. Preschool @entity0 can develop @entity2 and @entity3 , as well as @entity6 and @entity1 (the latter two mainly in @entity0 ). Parent training and parent- @entity0 psychotherapy have been found to be effective treatments. There is no evidence that psychotropic drugs are effective in early childhood. CONCLUSION: The diagnostician should act cautiously when assigning psychopathological significance to symptoms arising in early childhood but should still be able to recognize @entity1 early from the way they are embedded in the @entity0 's interactive relationships with parents or significant others, and then to initiate the appropriate treatment. Psychotherapy in this age group is still in need of validation by efficacy studies and longitudinal studies of adequate quality.

title: XXXX in Early Childhood.

answer: @entity1


abstract: Conventional chemotherapy is ineffective in the majority of @entity0 with @entity4 ( @entity4 ), and monoclonal antibodies recognising @entity2 expressed on myeloid progenitors (e.g. @entity5 (GO)) have been reported to improve outcome in @entity0 with @entity4 . Reports of excess @entity1 have resulted in GO's licence being withdrawn. As a result, the role of these agents remains unclear. A systematic review and meta-analysis included studies of @entity0 with @entity4 who had entered a randomised control trial (RCT), where one arm included anti- @entity2 antibody therapy. Fixed effect meta-analysis was used, involving calculation of observed minus expected number of events, and variance for each endpoint in each trial, with the overall treatment effect expressed as Peto's odds ratio with 95  % confidence interval. Meta-analysis of 11 RCTs with 13 randomisations involving GO was undertaken. Although GO increased induction deaths (p   =   0.02), it led to a reduction in resistant disease (p   =   0.0009); hence, there was no improvement in complete remission. Whilst GO improved relapse-free survival (hazard ratio (HR)   =   0.90, 95  % confidence interval (CI)   =   0.84-0.98, p   =   0.01), there was no overall benefit of GO in @entity3 ( @entity3 ) (HR   =   0.96, 95  % CI   =   0.90-1.02, p   =   0.2). GO improved @entity3 in @entity0 with favourable cytogenetics, with no evidence of benefit in @entity0 with intermediate or adverse cytogenetics (test for heterogeneity between subtotals p   =   0.01). GO has a potent clinically detectable anti-leukaemic effect. Further trials to investigate its optimum delivery and identification of @entity0 populations who may benefit are needed.

title: Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti- XXXX antibody treatment in @entity4 .

answer: @entity2


abstract: Electrophoretic conditions to separate @entity3 ( @entity0 )-protein complexes according to their relative molecular mass by capillary electrophoresis (CE) using linear @entity2 as a sieving matrix were examined. Five purified proteins with relative molecular masses between 14 400 and 66 200 Da were separated on a coated fused- @entity5 capillary with an internal diameter of 100 microm and an effective length of 24 cm (total length, 32.5 cm). @entity8 was added to the solution of purified proteins as internal standard; @entity6 was also added as reducing agent. The running buffer composition was 0.05 M @entity7 (Tris), 0.035 M @entity1 , 0.1% m/v @entity0 , 4% m/v @entity4 , the resulting pH being 8.0. The applied voltage was 7 kV (reversed voltage polarity) in order to avoid high current intensities. Under optimized conditions, the five proteins were separated in less than 15 min, with a % relative standard deviation (RSD) between 0.2 and 0.4 for migration times in the same day. Good efficiency (values between 150 000 and 40 000 N/m) and resolution (values between 2 and 2.8) were obtained. The inverse of relative migration times was found to correlate with the logarithm of their relative molecular mass. Finally, cider proteins were analyzed and their relative molecular masses were determined. These results were compared with those obtained by @entity0 - @entity2 gel electrophoresis ( @entity0 -PAGE).

title: Size-based separations of proteins by capillary electrophoresis using linear XXXX as a sieving medium: model studies and analysis of cider proteins.

answer: @entity2


abstract: @entity15 in the medial prefrontal cortex (mPFC) has been associated with the aetiology of negative symptoms and @entity2 of @entity4 , which are both alleviated by @entity10 and other atypical antipsychotics such as @entity9 . In rodents, early life exposure to stressful experiences such as social isolation produces a spectrum of symptoms emerging in adult life, which can be restored by antipsychotic drugs. The present series of experiments sought to investigate the effect of @entity10 (5-10 mg/kg s.c.), @entity9 (5 mg/kg s.c.), and @entity14 (0.5 mg/kg s.c.) on @entity8 (DA) and @entity13 in the prelimbic/infralimbic subregion of the mPFC in group- and isolation-reared @entity0 . @entity0 reared in isolation showed significant and robust deficits in prepulse inhibition of the acoustic startle. In group-reared animals, both @entity10 and @entity9 produced a significant increase in DA outflow in the mPFC. Isolation-reared @entity0 showed a significant increase in responsiveness to both atypical antipsychotics compared with group-reared animals. In contrast, the administration of @entity14 failed to modify dialysate DA levels in mPFC in either group- or isolation-reared animals. The results also show a positive relationship between the potency of the tested antipsychotics to increase the release of DA in the mPFC and their respective affinities for 5-HT1A relative to DA D2 or D3 receptors. Finally, isolation-reared @entity0 showed enhanced neurochemical responses to the highest dose of @entity10 as indexed by @entity6 , @entity5 , @entity12 , @entity11 , @entity16 , @entity18 , and @entity7 . The increased DA responsiveness to the atypical antipsychotic drugs @entity10 and @entity9 may explain, at least in part, @entity10 - and @entity9 -induced reversal of some of the major @entity3 , namely @entity17 and @entity1 .

title: Increased responsiveness of XXXX to atypical, but not typical antipsychotics in the medial prefrontal cortex of @entity0 reared in isolation.

answer: @entity8


abstract: The present study examined whether (1) the cough associated with @entity6 inhibitor therapy is attenuated by oral intake of @entity1 and anti-oxidants, and (2) @entity4 (NO) has any role in this attenuation. Of the 100 @entity0 under investigation, cough occurred in 28 of them with preponderance in females. All the 28 @entity0 were followed up for six weeks: the first two weeks were the observation period and the remaining four weeks the experimentation period. After the observation period, 11 @entity0 received a single oral dose of @entity8 (200 mg), eight received @entity2 (200 mg, o.d.) and @entity3 (150 mg, o.d.) and nine were given placebo during the experimentation period. Cough scoring, serum NO and @entity5 ( @entity7 ) levels were determined during both the periods. While there were significant decreases in cough scores, NO and @entity7 levels between these two periods in the @entity1 group, cough scores and @entity7 level decreased significantly in the anti-oxidant group. None of these parameters changed in the control group. NO level was found to be increased significantly in @entity0 who developed cough (n = 28) compared with those who did not cough (n = 72). These results suggest that @entity1 supplementation suppresses cough in @entity0 on ACE-I therapy through its effect on NO generation.

title: Attenuation of @entity6 inhibitor induced cough by @entity1 supplementation: role of XXXX .

answer: @entity4


abstract: UNASSIGNED: 3535 Background: In the era of personalized @entity2 treatment, @entity0 selection to enrich for specific targets is key to improve treatment outcome. Given the genomic instability of @entity2 in time we addressed whether analysis of the @entity2 or the @entity1 is most suitable for @entity0 selection for targeted treatment. METHODS: With next generation (SOLiD 3+ system, Life Technologies) and targeted sequencing (DNA capture-arrays, Agilent) we have analyzed the genetic environment of a @entity2 mini-genome-the exons of 1,265 @entity2 -associated genes- of the @entity2 and its sequential liver @entity1 in 21 @entity3 ( @entity3 ) @entity0 (pts). Using laser microdissection >80% @entity2 cell-enriched DNA was isolated from in total 47 samples, including healthy tissue of 5 pts. Sequence data was aligned and mapped against the @entity0 reference genome (GRCh37/hg19) using BWA. To limit the influence of SNV (Single Nucleotide Variation) caller artifacts we applied 3 different published methods (our PERL script, VarScan and GATK toolkit) and considered the overlapping variants as reliable. To predict the possible impact of identified SNV's on protein function polymorphism phenotyping version2 was used. RESULTS: All 47 samples were successfully sequenced (median coverage=87x, range: 52-217). In total 6,696 known (84%) and 1,305 novel (16%) SNV's were identified. These included 1,460 non-synonymous and 29 gained/lost stop-codons, potentially altering protein function. On average 83 potentially relevant SNV's were gained in the @entity1 and 70 SNVs present in the @entity2 were lost. Interestingly, these genetic variations affected several essential pathways. This demonstrated that @entity2 evolution caused losses and gains of critical genes in time. In this sample set genetic selection pressure concerning the amount of gained/ lost SNV's on the @entity1 due to chemotherapy could not be shown. CONCLUSIONS: These results indicate that @entity1 significantly differs from its primary origin in @entity3 pts. This suggests that for the selection of the appropriate @entity0 population for targeted therapy the @entity1 better reflects the @entity4 status.

title: Primary @entity3 and their XXXX are genetically not the same: Implications for choice of targeted treatment?

answer: @entity1


abstract: OBJECTIVE: To correlate the density of swellings in intraepidermal nerve fibers (IENF) with the longitudinal measurement of the epidermal innervation density in @entity0 with @entity5 and to assess the predictive value of IENF swelling to progression of @entity1 . METHODS: Fifteen @entity0 with persistent @entity2 in the feet underwent neurologic examination, nerve conduction studies, quantitative sensory examination, and skin biopsies at proximal thigh and distal leg. In all @entity0 and in 15 healthy subjects, IENF density and swelling ratio (no. swellings/no. IENF) were quantified at distal leg. Follow-up study, including IENF density and swelling ratio quantification, was performed a mean of 19.2 months later. Double staining confocal microscope studies using anti-human protein-gene-product 9.5, anti-tubule, anti-neurofilament, and anti- @entity4 antibodies were performed to assess specific accumulation within swellings. Ultrastructural investigation of IENF was also carried out. RESULTS: @entity0 with @entity1 had lower density of IENF and higher swelling ratio than healthy subjects (p < 0.01) at distal leg. At follow-up, @entity0 showed a parallel decrease in both IENF density (p = 0.02) and swelling ratio (p = 0.002). However, swelling ratio remained higher (p = 0.03) than in controls. @entity1 was confirmed by the @entity3 sensory nerve action potential amplitude. Double immunostaining studies suggest accumulation of tubules and ubiquitin-associated proteins within swellings. Swollen and vacuolated IENF were identified in @entity0 with @entity1 by conventional and immuno-electron microscopy. CONCLUSIONS: Increased swelling ratio predicted the decrease in IENF density in @entity0 with @entity5 . Its quantification could support earlier diagnosis of sensory axonopathy.

title: Axonal swellings predict the degeneration of epidermal nerve fibers in painful XXXX .

answer: @entity1


abstract: BACKGROUND: As a result of the improvement of pharmacological and non-pharmacological treatment of @entity1 @entity0 , the @entity1 regimen is becoming more complicated, especially for elderly @entity0 with co-morbid diseases. Non-adherence to this regimen is a problem in many @entity1 @entity0 , leading to worsening symptoms, rehospitalization and decreased quality of life. AIM: This paper gives an overview of literature on adherence to pharmacological and non-pharmacological treatment in elderly @entity1 @entity0 . The paper addresses the definition of adherence and the extent and significance of the problem of non-adherence in elderly @entity1 @entity0 . Factors contributing to non-adherence, focused on the elderly are outlined and finally interventions to improve adherence in this elderly @entity1 @entity0 group are described. CONCLUSION: Non-adherence to medication and lifestyle recommendations is a major problem in elderly @entity1 @entity0 . Five dimensions that affect adherence are described consisting of social and economic factors, factors related to the health care system, to the condition of the @entity0 , the therapy and factors related to the @entity0 . Since non-adherences is a multidimensional problem, interventions need to be directed to all factors that are related to adherence in elderly @entity1 @entity0 . A multidisciplinary approach in a @entity1 team is crucial to improve adherence in this vulnerable @entity0 group. Effectiveness of interventions to improve adherence in elderly @entity1 @entity0 needs to be further tested.

title: Adherence in XXXX in the elderly: problem and possible solutions.

answer: @entity1