abstract: OBJECTIVE: To assess the efficacy and tolerability of @entity4 20mg daily, for the treatment of @entity2 and @entity2 associated with @entity1 . METHOD: An open, non-comparative study undertaken at three centers in three cities of Pakistan. A total of 112 in- or out- @entity0 , presenting with a major @entity2 were included in the study. @entity2 was diagnosed according to DSM IV criteria and a Hamilton Rating Scale for @entity2 (HAMD-D) score of >18 on the first 17 items of the HAM-D-21. After a placebo washout period of 7 days, @entity0 were given a 20-mg fixed dose of @entity4 daily in the morning for a period of 6 weeks. After baseline, regular assessments were made at 1, 2, 4 and 6 weeks. Efficacy measures included the HAMD-D, the Clinical Anxiety Scale, The Clinical Global Impression Severity of Illness Scale (CGI-S), and the Clinical Global Impression Improvement Scale (CGI-I). Tolerability was assessed by any adverse event. The primary therapeutic outcome measures were @entity0 who achieved a 50% or greater reduction in HAMD-D score at the end of the treatment or achieved a reduction in final HAMD-D score of < or = 10 points. The final scores of 1 or 2 for CGI-S and CGI-I were considered as full clinical response. RESULTS: Of 112 cases evaluated, 57 were males and 55 females whose ages ranged from 18 to 65 years. There was a clear and statistically significant efficacy of @entity4 on all the major outcome variables. A total of 88% @entity0 achieved a reduction in the final HAMD-D score at the end of treatment. The total HAM-D score reduced to 10 or less in 73% @entity0 at 6 weeks and by this week 76% and 92% @entity0 achieved a score of 1 or 2 for CGI-S and CGI-I, respectively. The mean Clinical Anxiety Scale score reduced from 12.6 at the baseline to 4.4 at the end of treatment. Safety data was evaluated in all 112 @entity0 and @entity4 was well tolerated. Adverse events were experienced by 10% of @entity0 of whom 4% were dropped from the study. @entity3 was the commonest adverse event reported. CONCLUSION: The study shows that @entity4 is an effective, well-tolerated, and safe drug for the treatment of @entity2 .

title: Efficacy and tolerability of @entity4 20 mg daily in the treatment of XXXX and @entity2 associated @entity1 .

answer: @entity2


abstract: BACKGROUND: @entity2 is considered a @entity1 in which @entity0 may have delayed @entity3 . The effects of total abdominal colectomy and ileorectal anastomosis on @entity6 are unknown. The aim of this study was to evaluate @entity3 in @entity0 with @entity2 before and after subtotal colectomy. METHODS: Gastric emptying of a solid meal was studied by scintigraphic technique in 11 @entity0 with @entity2 . The total colonic transit time was more than 72 hours in all @entity0 studied, with delay in transit in all segments of the colon. The @entity3 test was repeated 3 to 6 months after total abdominal colectomy and ileorectal anastomosis in ten of these @entity0 . Before and after surgery, @entity0 filled out a questionnaire to record upper gut symptoms. RESULTS: Solid @entity3 was delayed (T1/2 > upper limit of normal) in 7 of 11 @entity0 with @entity2 . Gastric emptying T1/2 was almost similar before and after surgery. Mean +/- standard deviation was 142 +/- 91 minutes before surgery and 146 +/- 67 minutes after surgery. Symptoms of @entity5 and belching improved significantly after surgery. Symptoms of @entity4 , bloating, and @entity7 also decreased, but these changes failed to reach statistical significance. CONCLUSION: Despite a reduction in upper gut symptoms, total abdominal colectomy and ileorectal anastomosis does not improve delayed @entity3 in @entity0 with @entity2 .

title: Effect of subtotal colectomy on XXXX of a solid meal in slow-transit constipation.

answer: @entity3


abstract: @entity4 is the 9(th) most common @entity1 worldwide. Most @entity1 are non-muscle invasive on presentation. However, two-thirds of non-invasive @entity3 will eventually recur with a 25% risk of progression to @entity3 . @entity1 stage, histological grade and pathological invasion of blood vessels and lymphatic tissue are the main indicators for @entity1 prognosis. The gold standard for diagnosing @entity3 is conventional white-light cystoscopy and biopsy. Urine cytology is a highly specific, sensitive test for high-grade @entity1 or @entity7 ( @entity7 ). Urinary @entity8 has an overall sensitivity and specificity for detecting @entity3 of 49% and 87%, respectively. However, there are false-positive results in the presence of @entity5 or @entity6 . The detection of specific gene mutations related to @entity1 has been studied and employed to reproduce markers helpful for diagnosis. According to current studies, molecular markers can be used to predict @entity1 recurrence. From a prognostic point of view, new molecular markers have yet to be established as reliable indicators of @entity2 . We aimed to review the molecular markers with possible prognostic significance that have been discussed in the literature. This review examined the literature for various molecular markers under development for @entity3 in an attempt to optimize @entity0 care and reduce the costs of treating these @entity0 .

title: What are the currently available and in development molecular markers for XXXX ? Will they prove to be useful in the future?

answer: @entity3


abstract: UNASSIGNED: Intravascular @entity3 (IPEH) is a benign lesion of the skin and mucosa of vascular origin characterized by reactive proliferation of endothelial cells. A 76-year-old @entity0 was referred presenting a painless nodule on the lip. Intraoral examination revealed bluish submucosal nodular proliferation, measuring 10 * 5 * 5   mm, affecting the lower labial mucosa. The lesion had a firm consistency and it was not fixed to the adjacent tissues. The main differential diagnoses were mucocele/mucus retention cyst, sialolith, or @entity1 . An incisional biopsy was performed and during the intraoperative procedure an encapsulated red-bluish nodular mass was observed. Microscopic analysis revealed papillary endothelial proliferation in the center of the lesion and fibrin admixed with inflammatory cells in organization peripherally. There was no nuclear atypia, mitotic figures, or @entity2 . The endothelial cells were @entity5 positive, with low Ki-67 proliferation index (4%). @entity4 highlighted the vessel walls, whereas negativity for D2-40 excluded lymphatic origin. Final diagnosis was IPEH associated with an organizing thrombus. Dentists should be aware about this rare benign vascular lesion, whose final diagnosis is achieved only after histopathology analysis. Surgical removal is the treatment of choice and no recurrence is expected.

title: Oral Intravascular XXXX Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis.

answer: @entity3


abstract: The Semipalatinsk nuclear test site (SNTS), the Republic of Kazakhstan, has been contaminated by radioactive fallout. The alteration of oncogenic molecules in @entity1 around the SNTS was considered worthy of analysis because it presented the potential to elucidate the relationship between radiation exposure and @entity1 . This study aimed to analyze both @entity4 and @entity6 expressions in @entity1 around the SNTS. We examined nine cases of @entity7 , eight cases of @entity2 , and 23 cases of @entity3 . Immunohistochemically, all @entity0 displayed a strong cytosolic @entity4 expression, while both @entity7 and @entity2 showed a significantly lower cytoplasmic @entity4 (22.2% and 37.5%, respectively). No @entity6 immunoreactivity was evident in @entity7 . In contrast, 62.5% of @entity2 and 87.0% of @entity3 showed @entity6 overexpression. Additionally, a strong correlation between cytoplasmic @entity4 and @entity6 expression was suggested in @entity1 . This study revealed a higher prevalence of both aberrant @entity4 expression and @entity6 overexpression in @entity5 around the SNTS than sporadic cases. The analysis of the alteration of the Wnt signaling-related molecules in @entity1 around the SNTS may be important to gain an insight into radiation-induced thyroid tumorigenesis.

title: Correlation of cytoplasmic @entity4 and XXXX overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site.

answer: @entity6


abstract: OBJECTIVE: To analyze the effect of serum levels of high molecular weight @entity2 (HMWA) on the occurrence of @entity3 during subsequent pregnancy in @entity0 with primary pregnancy-induced @entity1 ( @entity4 ). @entity0 AND METHODS: Thirty @entity0 with primary @entity4 (observation group) and sixty @entity0 without primary @entity4 (control group) were consecutively selected. ELISA was used to measure the serum levels of HMWA. The differences in the occurrence of @entity3 during subsequent pregnancy between the two groups were compared. RESULTS: The serum levels of HMWA in the observation group were significantly lower than in the control group, and they decreased with increased severity of @entity4 (p < 0.05). In the observation group, the gestational age was lower than that of the control group, and the occurrence of cesarean section and maternal complications were increased. The neonatal weight and Apgar scores were lower than those of the control group, and the occurrence of neonatal complications was increased. The difference was statistically significant (p < 0.05). There were no differences in the time intervals between pregnancies in the two groups. The occurrence of @entity4 and @entity3 during subsequent pregnancy in the observation group was significantly higher than that in the control group (p < 0.05). According to receiver operating curve analysis, the sensitivity, specificity, and accuracy of serum HMWA level in predicting the occurrence of @entity3 during subsequent pregnancy were 85.6%, 74.8%, and 0.824 (95% CI = 0.811-0.936, p = 0.015), respectively. The critical value was 2.4 mg/l. CONCLUSIONS: Decreases of serum levels of HMWA in @entity0 with primary @entity4 are closely related to the severity of @entity4 and the outcome of pregnancy, which has important predictive value for the occurrence of @entity3 during subsequent pregnancy.

title: Effect of serum high molecular weight @entity2 level on the occurrence of @entity3 during subsequent pregnancy in @entity0 with primary pregnancy induced XXXX .

answer: @entity1


abstract: "Blue eye" disease of @entity5 in Mexico is caused by @entity11 and characterized by @entity2 in sows and boars, nervous signs in young @entity5 , and @entity8 in @entity5 of all ages. The pathogenesis of reproductive tract lesions in rubulavirus-infected boars has not previously been investigated. In a first experiment, four 9-month-old boars were inoculated with @entity11 and killed 5, 15, 30 or 45 days post-inoculation (pi). In a second experiment, four similar boars were inoculated with the same virus and two animals were killed on each of days 70 and 80 pi. Swelling of the head of the epididymis developed in all inoculated boars at approximately day 15 pi. @entity4 and concentration were detected in semen samples collected from one boar from day 21 pi. At post-mortem examination, nodules were seen in the head of the epididymis of the boars killed 15, 30 or 45 days pi and the right testis of the @entity5 killed 30 days pi was @entity6 . Corresponding histopathological epididymal alterations included formation of spermatic @entity3 and @entity10 of ductular epithelium. These lesions were associated with mononuclear cell infiltration and interstitial @entity7 . Degeneration of seminiferous tubules and interstitial mononuclear cell infiltration were seen in the @entity6 of the @entity5 killed 30 days pi. There was @entity0 of the head of the epididymis in all boars killed 70 or 80 days pi and one of these animals also had right testicular @entity1 associated with degeneration of seminiferous tubules, lymphocytic infiltration and giant cell formation. Porcine rubulavirus antigen was detected by immunofluorescence labelling in the head of the epididymis of the @entity5 killed 15, 30 or 45 days pi and in one animal killed on day 70 pi. These results indicate that @entity11 can cause severe @entity9 and reduced semen quality in sexually mature boars.

title: Lesions in the reproductive tract of boars experimentally infected with XXXX .

answer: @entity11


abstract: @entity3 ( @entity2 ) ingestion during exercise, in the form of @entity2 -electrolyte beverages, leads to performance benefits during prolonged submaximal and variable intensity exercise. However, the mechanism underlying this ergogenic effect is less clear. Euglycaemia and oxidation of blood @entity1 at high rates late in exercise and a decreased rate of muscle glycogen utilisation (i.e. glycogen 'sparing') have been proposed as possible mechanisms underlying the ergogenic effect of @entity2 ingestion. The prevalence of one or the other mechanism depends on factors such as the type and intensity of exercise, amount, type and timing of @entity2 ingestion, and pre-exercise nutritional and training status of study @entity0 . The type and intensity of exercise and the effect of these on blood @entity1 , plasma @entity4 and @entity5 levels, may play a major role in determining the rate of muscle glycogen utilisation when @entity2 is ingested during exercise. The ingestion of @entity2 (except fructose) at a rate of > 45 g/h, accompanied by a significant increase in plasma @entity4 levels, could lead to decreased muscle glycogen utilisation (particularly in type I fibres) during exercise. Endurance training and alterations in pre-exercise muscle glycogen levels do not seem to affect exogenous @entity1 oxidation during submaximal exercise. Thus, at least during low intensity or intermittent exercise, @entity2 ingestion could result in reduced muscle glycogen utilisation in well trained individuals with high resting muscle glycogen levels. Further research needs to concentrate on factors that regulate @entity1 uptake and energy metabolism in different types of muscle fibres during exercise with and without @entity2 ingestion.

title: @entity0 muscle glycogen metabolism during exercise. Effect of XXXX supplementation.

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to evaluate the significance of the development of a restrictive response to an acute saline load, defined as an increase in the ratio of peak early to peak late diastolic transmitral flow velocity (E/A ratio) associated with a decrease in the deceleration time, in @entity0 with mild to moderate untreated @entity1 . BACKGROUND: Recognised abnormal patterns of transmitral diastolic flow include, from 'best' to 'worst': prolonged relaxation, pseudonormalisation, and restrictive physiology. The common denominator of these transitions is the constellation of an increase in the E/A ratio associated with a decrease in deceleration time. @entity0 AND METHODS: Sixteen normal control subjects (6 males, 10 females, age 51.6 +/- 6.9 years) and 24 @entity0 with mild to moderate untreated @entity1 (12 males, 12 females, age 46.8 +/- 7.5 years) underwent supine blood pressure measurement with sphygmomanometry, biochemical studies, and transthoracic M-mode, 2D, and Doppler echocardiography before and after an acute saline load (7 mL kg(-1), maximum 500 mL, @entity2 0.9% within 15 min IV). RESULTS: The baseline E/A ratio was lower (0.90 +/- 0.14 vs. 1.04 +/- 0.18; P < 0.01) and the deceleration time was longer (158.8 +/- 19.4 vs. 135 +/- 8.9 ms; P < 0.01) in @entity0 with @entity1 compared with normotensive controls. However, no @entity0 with @entity1 exhibited a transmitral flow velocity pattern compatible with typical prolonged relaxation. A restrictive response to the acute saline load was observed in 12 (50%) of the @entity1 and none of the control subjects. @entity1 @entity0 with a restrictive response to the acute saline load had a lower baseline E velocity (54.8 +/- 8.7 cm s(-1) vs. 66 +/- 6.4 cm s(-1); P = 0.003), a lower baseline E/A ratio (0.83 +/- 0.13 vs. 0.97 +/- 0.12; P = 0.015), and a longer deceleration time (167.5 +/- 15.4 ms vs. 150 +/- 19.5; P = 0.03) than @entity1 @entity0 without such a response. CONCLUSION: A restrictive response to an acute saline load is indicative of a limited diastolic reserve in @entity0 with mild to moderate untreated @entity1 . Further studies are required in order to evaluate the significance of such a response with regards to risk stratification and efficacy of medical treatment in this @entity0 population.

title: Assessment of the left ventricular diastolic reserve in essential XXXX : the acute saline load test.

answer: @entity1


abstract: OBJECTIVE: To study the clinicopathological features of @entity3 ( @entity3 ) of breast and the diagnosis and treatment of the disease. METHODS: The clinical, operative and pathological data from 7 cases of @entity0 were retrospectively analysed. RESULTS: Five @entity1 complained of painless mass and two of them were accompanied with @entity2 . All @entity1 were diagnosed as having @entity3 by fine-needle aspiration before operation. Two @entity1 underwent modified radical mastectomy, and the others received radical mastectomy. Pathological examination showed @entity3 of the breast with metastasis to axlliary lymph nodes in one @entity1 . Follow-up of four @entity1 revealed that two @entity1 are living well and two @entity1 died. Three @entity1 lost to follow up. CONCLUSION: The diagnosis of @entity3 of the breast is dependent on pathological results. Radical mastectomy including modified radical mastectomy is most effective in the treatment of mammary @entity3 . Postoperative chemotherapy and radiation are necessary auxiliary therapy.

title: [Clinical analysis of XXXX of the breast].

answer: @entity3


abstract: @entity4 -like toxin (SLT) has been implicated in the pathogenesis of @entity3 and its attendant endothelial cell (EC) injury. Key serotypes of @entity1 produce @entity5 in addition to another highly pro-inflammatory molecule, lipopolysaccharide (LPS). It has previously been established that @entity5 induces EC apoptosis and that LPS enhances this effect. LPS alone has no affect on @entity0 EC viability, and the mechanism for this enhancement remains unknown. In the present report, we demonstrate that @entity5 sensitizes EC to LPS-induced apoptosis. Pretreatment with @entity5 sensitized EC to LPS-induced apoptosis, whereas pretreatment with LPS did not influence @entity5 -induced apoptosis. @entity5 exposure resulted in decreased expression of @entity2 ( @entity2 ), an anti-apoptotic protein that has previously been shown to block LPS-induced apoptosis. This @entity5 -mediated decrease in @entity2 expression preceded the onset of apoptosis elicited by @entity5 alone or in combination with LPS. @entity5 -mediated decrements in @entity2 expression correlated in a dose- and time-dependent manner with sensitization to LPS-induced apoptosis. Finally, transient or stable overexpression of @entity2 protected against LPS enhancement of @entity5 -induced apoptosis, and this protection corresponded with sustained expression of @entity2 . Together, these data suggest that @entity5 sensitizes EC to LPS-induced apoptosis by inhibiting @entity2 expression.

title: XXXX -like toxin inhibition of @entity2 expression sensitizes endothelial cells to bacterial lipopolysaccharide-induced apoptosis.

answer: @entity4


abstract: OBJECTIVE: The purpose of this study was to assess the prevalence of @entity4 ( @entity4 ) @entity6 in @entity1 with @entity0 and compare breast MRI and PET/CT for detection of @entity4 @entity6 . MATERIALS AND METHODS: This retrospective study included 90 @entity1 who underwent MRI and PET/CT before neoadjuvant chemotherapy for clinical stage IIA through IIIA disease. MRI and PET/CT examinations were read independently by two readers trained in breast imaging and nuclear medicine. All @entity1 underwent follow-up MRI at the end of chemotherapy, and 10 with @entity5 IMNs underwent follow-up PET/CT. Histology was not obtained. @entity1 were considered to have @entity4 @entity6 when nodes seen on MRI or having standardized uptake value (SUV) greater than mediastinal blood pool decreased in either size or SUV (or both) after treatment. Features including lymphovascular invasion, @entity3 quadrant(s), and axillary @entity6 were compared between presence and absence of @entity4 @entity6 using Fisher's exact test. Prevalence was determined on the basis of the percentage of @entity1 with @entity4 @entity6 by either modality. The McNemar test compared the prevalence of @entity4 @entity6 on MRI to its prevalence on PET/CT. RESULTS: Prevalence of @entity4 @entity6 was 16% (14/90) by MRI and 14% (13/90) by PET/CT (p = 0.317). After chemotherapy, @entity4 @entity6 resolved in 12 of 14 @entity1 (86%). In two @entity1 with poor responses in @entity3 , @entity4 @entity6 persisted, and both @entity1 developed @entity2 within 6 months. At 3 years, survival was significantly worse in @entity1 with @entity4 @entity6 than in those without (85.7% vs 53.3%, respectively; p = 0.009). CONCLUSION: In @entity1 with @entity0 receiving neoadjuvant chemo-therapy, prevalence of @entity4 @entity6 was 16%, equally detected by breast MRI and PET/CT. Identification of @entity4 @entity6 may affect treatment and provides prognostic information.

title: Detection of Internal Mammary Adenopathy in XXXX With @entity0 by PET/CT and MRI.

answer: @entity1


abstract: INTRODUCTION: As technological advances allow for the development of more sophisticated measurement of the mechanisms that contribute to compensation for loss of circulating blood volume such as @entity1 , it is important to compare the discriminative ability of these new measures to standard vital signs and other new physiologic metrics of interest. The purpose of this study was to compare the discriminative ability of the following three measures to predict the onset of hemodynamic decompensation: peripheral perfusion index (PPI), pulse pressure variability ( @entity3 ), and the compensatory reserve index (CRI). MATERIALS AND METHODS: There were 51 healthy @entity0 who underwent a progressive simulated @entity1 to induce central @entity4 by lower body negative pressure (LBNP). The least-squares means and 95% confidence intervals for each measure were reported by LBNP level and stratified by tolerance status (high tolerance vs. low tolerance). Generalized estimating equations were used to perform repeated measures logistic regression analysis by regressing the onset of hemodynamic decompensation on each of the vital signs of interest. These probabilities were used to calculate sensitivity, specificity, and receiver-operating characteristic area under the curve (ROCAUC) for PPI, @entity3 , and CRI. RESULTS: Compared with both @entity3 (ROCAUC=0.79) and PPI (0.56), the CRI (0.90) had superior discriminative ability (P <=0.0001) to predict the onset of hemodynamic decompensation. This included higher sensitivity (0.86 vs. 0.78 and 0.71) and specificity (0.78 vs. 0.69 and 0.29) for the CRI compared with @entity3 and PPI, respectively. Further, CRI was the only measure with mean predicted probabilities of the onset of hemodynamic decompensation that progressively increased as the level of simulated @entity1 increased. DISCUSSION: There are two potential rationales for why the CRI had superior discriminative ability to predict hemodynamic decompensation. First, the CRI more accurately predicted the onset of hemodynamic decompensation at all levels of simulated @entity1 , but especially at lower levels of @entity1 . Second, the CRI was better able to differentiate high versus low tolerant @entity0 . CONCLUSION: Consistent with previous research, the CRI had superior discriminative ability to predict the onset of hemodynamic decompensation. For those @entity0 at greatest risk for developing impending @entity2 , identifying the most sensitive and specific measures of the onset of hemodynamic decompensation is critical for both the early recognition and implementation of life-saving interventions.

title: Predictors of the Onset of Hemodynamic Decompensation XXXX : Comparison of the Peripheral Perfusion Index, Pulse Pressure Variability, and Compensatory Reserve Index.

answer: @entity4


abstract: One of the hallmark events regulating the process of osteogenesis is the transition of undifferentiated @entity0 mesenchymal stem cells (hMSCs) found in the bone marrow into mineralized-matrix producing osteoblasts (hOSTs) through mechanisms that are not entirely understood. With recent developments in mass spectrometry and its potential application to the systematic definition of the stem cell proteome, proteins that govern cell fate decisions can be identified and tracked during this differentiation process. We hypothesize that protein profiling of hMSCs and hOSTs will identify potential osteogenic marker proteins associated with hMSC commitment and hOST differentiation. To identify markers for each cell population, we analyzed the expression of hMSC proteins and compared them to that of hOST by two-dimensional gel electrophoresis and two-dimensional liquid chromatography tandem mass spectrometry (2D LC- @entity1 / @entity1 ). The 2D LC- @entity1 / @entity1 data sets were analyzed using the Database for Annotation, Visualization and Integrated Discovery (DAVID). Only 34% of the spots in 2D gels were found in both cell populations; of those that differed between populations, 65% were unique to hOST cells. Of the 755 different proteins identified by 2D LCMS/ @entity1 in both cell populations, two sets of 247 and 158 proteins were found only in hMSCs and hOST cells, respectively. Differential expression of some of the identified proteins was further confirmed by Western blot analyses. Substantial differences in clusters of proteins responsible for @entity2 - based signaling and cell adhesion were found between the two cell types. Osteogenic differentiation is accompanied by a substantial change in the overall protein expression profile of hMSCs. This study, using gene ontology analysis, reveals that these changes occur in clusters of functionally related proteins. These proteins may serve as markers for identifying stem cell differentiation into osteogenic fates because they promote differentiation by mechanisms that remain to be defined.

title: Comparing the protein expression profiles of @entity0 mesenchymal stem cells and XXXX osteoblasts using gene ontologies.

answer: @entity0


abstract: Fusarium head blight (FHB) caused by the filamentous fungus @entity2 is one of the most severe diseases threatening the production of small grains. Infected grains are often contaminated with mycotoxins such as @entity3 and trichothecences. During survey of contamination by FHB in @entity0 grains, we found a bacterial isolate, designated as BN1, antagonistic to @entity2 . The strain BN1 had branching vegetative hyphae and spores, and its aerial hyphae often had long, straight filaments bearing spores. The 16S rRNA gene of BN1 had 100% sequence identity with those found in several Streptomyces species. Phylogenetic analysis of ITS regions showed that BN1 grouped with S. sampsonii with 77% bootstrap value, suggesting that BN1 was not a known Streptomyces species. In addition, the efficacy of the BN1 strain against @entity2 strains was tested both in vitro and in vivo. @entity1 seedling length was significantly decreased by @entity2 infection. However, this effect was mitigated when @entity1 seeds were treated with BN1 spore suspension prior to @entity2 infection. BN1 also significantly decreased FHB severity when it was sprayed onto @entity1 heads, whereas BN1 was not effective when @entity1 heads were point inoculated. These results suggest that spraying of BN1 spores onto @entity1 heads during the @entity1 flowering season can be efficient for plant protection. Mechanistic studies on the antagonistic effect of BN1 against @entity2 remain to be analyzed.

title: Biological Efficacy of Streptomyces sp. Strain BN1 against the Cereal Head Blight Pathogen XXXX .

answer: @entity2


abstract: BACKGROUND: @entity4 ( @entity8 ) and @entity7 mofetil ( @entity5 ) are currently approved immunosuppressants for prevention of rejection in liver transplantation (LTx). They have different modes of action and @entity1 profiles, but the efficacy and safety of @entity5 in primary liver transplantation with @entity8 has not been determined. METHODS: An Institutional Review Board-approved, open-label, single-center, prospective randomized trial was initiated to study the efficacy and @entity1 of @entity8 and @entity2 (double-drug therapy (D)) versus @entity8 , @entity2 , and @entity5 (triple-drug therapy (T)) in primary adult LTx recipients. Both groups of @entity0 were started on the same doses of @entity8 and @entity2 . @entity0 randomized to T also received 1 gm @entity5 twice a day. RESULTS: Between August 1995 and May 1998, 350 @entity0 were enrolled at a single center-175 in the D and 175 in the T groups. All @entity0 were followed until May 1998, with a mean follow-up of 33.8+/-9.1 months. Using an intention-to-treat analysis, the 1-, 2-, 3-, and 4-year @entity0 survival was 85.1%, 81.6%, 78.6%, and 75.8%, respectively, for D and 87.4%, 85.4%, 81.3%, and 79.9%, respectively, for T. The 4-year graft survival was 70% for D and 72.1% for T. Although the rate of acute rejection in the first 3 months was significantly lower for T than for D (28% for triple vs. 38.9% for double, P=0.03), the overall rate of rejection for T at the end of 1 year was not significantly lower than for the D (38.9% triple vs. 45.2% double). The median time to the first episode of rejection was 14 days for D versus 24 days for T (P=0.008). During the study period, 38 of 175 @entity0 in D received @entity5 to control ongoing acute rejection, nephrotoxicity, and/or @entity6 . On the other hand, 103 @entity0 in the T discontinued @entity5 for infection, @entity3 . The need for corticosteroids was less after 6 months for T and the perioperative need for dialysis was lower with use of @entity5 . CONCLUSION: This final report confirms similar @entity0 survival and graft survival up to 4 years with a trend towards fewer episodes of rejection, lower need for @entity2 , and better perioperative renal function. However, the complex nature of LTx @entity0 and their posttransplantation course prevents the routine application of @entity5 .

title: A prospective randomized trial of XXXX and prednisone versus @entity4 , prednisone and mycophenolate mofetil in primary adult liver transplantation: a single center report.

answer: @entity4


abstract: Importance: Blood transfusion can be a lifesaving treatment for the surgical @entity0 , yet transfusion-related immunomodulation may underlie the association of allogeneic transfusion with increased perioperative morbidity and possibly poorer long-term oncologic outcomes. Objective: To evaluate trends in transfusion rates for major abdominal oncologic resections to assess changes in recent clinical practice (given the accumulating evidence of the deleterious effects of blood transfusion). Design, Setting, and @entity0 : Retrospective review of a population-based registry of all hospitals participating in the American College of Surgeons National Surgical Quality Improvement Project (2005-2013 @entity0 Use Data Files), which was queried for @entity0 who underwent major resection of a pancreatic, hepatic, or gastric @entity1 . Data analysis was performed from July to August 2015. Main Outcome and Measures: The primary outcome was the transfusion of any quantity of packed red blood cells. Transfusion rates were calculated for the perioperative period, which was defined as the time from the start of surgery to 72 hours after surgery. Secondary outcomes included @entity4 , @entity3 , and @entity2 , and the rates of these complications were calculated as well. Trend analysis was performed for each year of data to evaluate for changes over the study period. Results: A total of 19   680 @entity0 (median age, 65.0 years [interquartile range, 57.0-73.0 years]) were identified, of whom 5900 (30.0%) received a blood transfusion (of 13   657 @entity0 who underwent a pancreatic resection, 4074 required transfusion [29.8%]; of 1605 @entity0 who underwent a gastric resection, 378 required transfusion [23.6%]; and of 4418 @entity0 who underwent a hepatic resection, 1448 required transfusion [32.8%]). There was a significant trend toward decreasing rates of transfusion during the study period (z   =   -7.89, P   <   .001), which corresponded to an absolute 6.1% decrease in the rate of transfusion of packed red blood cells from 2005 to 2013 (ie, from 32.8% to 26.7%). There was no significant change in the rates of @entity5 or @entity2 during this time period, but there was an increased rate of perioperative @entity3 during the study period (0.33% absolute increase; z   =   3.15, P   =   .002). Conclusions and Relevance: Over 9 years of contemporary practice, a trend of less perioperative blood transfusions for oncologic abdominal surgery was observed. Further studies are needed to assess whether these trends reflect changes in operative techniques, hospital cohorts, or transfusion thresholds.

title: Blood Transfusion in Major Abdominal Surgery for XXXX : A Trend Analysis Using the National Surgical Quality Improvement Program.

answer: @entity1


abstract: UNASSIGNED: In up to 30  % of @entity0 with @entity5 , no germline mutation in the known genes @entity3 , causing @entity3 , @entity8 , causing @entity8 -associated @entity3 , and POLE or @entity6 , causing Polymerase-Proofreading-associated @entity3 can be identified, although a hereditary etiology is likely. To uncover new causative genes, exome sequencing was performed using DNA from leukocytes and a total of 12 @entity4 from seven unrelated @entity0 with unexplained sporadic @entity3 . For data analysis and variant filtering, an established bioinformatics pipeline including in-house tools was applied. Variants were filtered for rare truncating point mutations and copy-number variants assuming a dominant, recessive, or @entity1 suppressor model of inheritance. Subsequently, targeted sequence analysis of the most promising candidate genes was performed in a validation cohort of 191 unrelated @entity0 . All relevant variants were validated by Sanger sequencing. The analysis of exome sequencing data resulted in the identification of rare loss-of-function germline mutations in three promising candidate genes ( @entity7 , @entity9 , @entity10 ). In the validation cohort, further variants predicted to be pathogenic were identified in @entity7 and @entity9 . According to the somatic mutation spectra, the @entity2 in this @entity0 cohort follow the classical pathways of colorectal tumorigenesis. The present study identified three candidate genes which might represent rare causes for a predisposition to @entity4 formation. Especially @entity9 ( @entity9 ) and @entity10 ( @entity10 ) warrant further exploration. To evaluate the clinical relevance of these genes, investigation of larger @entity0 cohorts and functional studies are required.

title: Exome sequencing identifies potential novel candidate genes in @entity0 with unexplained XXXX .

answer: @entity5


abstract: BACKGROUND: Current strategies for management of acute @entity4 ( @entity4 ) include thrombolysis, angioplasty, and coronary bypass surgery singly or in combination. This study was designed to identify contemporary risk factors for coronary bypass surgery among @entity0 in this high-risk group. METHODS: Between June 1992 and December 1995, 1181 consecutive @entity0 underwent isolated coronary bypass surgery. Of these, 316 underwent coronary bypass surgery within 21 days of @entity4 . Mean age was 65 years (range, 33 to 87 years), and 73% were male. There were 166 @entity0 with @entity9 (group 1), 107 @entity0 with @entity8 requiring intravenous @entity6 for a control of @entity1 (group 2), 20 @entity0 with angina requiring @entity5 for stabilization (group 3), and 23 @entity0 with severe postinfarction @entity1 complicated by @entity7 (group 4). RESULTS: The overall in-hospital mortality rate was 5.1% (16 of 316), which was higher (p < 0.05) than the 2.5% (22 of 865) among @entity0 undergoing coronary bypass surgery without recent @entity4 . Mortality increased with severity of clinical preoperative status and was 1.2% in group 1, 3.7% in group 2, 20.0% in group 3, and 26% in group 4. Serious postoperative morbidity occurred in 7.3% of @entity0 . Multivariate logistic regression analysis identified preoperative @entity5 , left @entity2 , and @entity3 as the only independent correlates of mortality. CONCLUSIONS: Coronary bypass surgery can be safely performed in stable @entity0 at any time after acute @entity4 , with an operative mortality similar to elective surgery. Thus, in this era of medical cost containment, there is no apparent indication for prolonged stabilization attempts that delay surgery.

title: Risk analysis of coronary bypass surgery after acute XXXX .

answer: @entity4


abstract: BACKGROUND: Evidence suggests that minimally invasive radical prostatectomy (MRP) and open radical prostatectomy (ORP) have similar short-term clinical and functional outcomes. MRP with robotic assistance is generally more expensive than ORP, but it is not clear whether subsequent costs of care vary by approach. METHODS: In the Surveillance, Epidemiology, and End Results (SEER) @entity1 registry linked with Medicare claims, @entity0 aged 66 years or older who received MRP or ORP in 2003 through 2006 for @entity2 were identified. Total cost of care was estimated as the sum of Medicare payments from all claims for hospital care, outpatient care, physician services, home health and hospice care, and durable medical equipment in the first year from the date of surgical admission. The impact of surgical approach on costs was estimated, controlling for @entity0 and disease characteristics. RESULTS: Of 5445 surgically treated @entity2 @entity0 , 4454 (82%) had ORP and 991 (18%) had MRP. Mean total first-year costs were more than  1200 greater for MRP compared with ORP ( 16,919 vs  15,692; P = .08). Controlling for @entity0 and disease characteristics, MRP was associated with 2% greater mean total payments, but this difference was not statistically significant. First-year costs were greater for @entity0 who were older, black, lived in the Northeast, had lymph node involvement, more @entity1 stage, or greater comorbidity. CONCLUSIONS: In this population-based cohort of older @entity0 , MRP and ORP had similar economic outcomes. From a payer's perspective, any benefits associated with MRP may not translate to net savings compared with ORP in the first year after surgery.

title: Costs of medical care after open or minimally invasive XXXX surgery: a population-based analysis.

answer: @entity2


abstract: BACKGROUND: The management of @entity3 ( @entity3 ) has been included as a standard of care in our therapeutic algorithm after diagnosis of @entity1 ( @entity1 ), following cardiac surgery. This report is an updated review of our results compared to previous experience. MATERIALS AND METHODS: A retrospective, observational, cohort study on a series of 26 @entity0 (20 males, 6 females, mean age 75.2 years, min 64, max 83) who developed @entity1 , out of 7.719 @entity0 undergoing cardiac operations (january 2005 - December 2014). The initial treatment consisted of laparotomy with abdominal decompression and temporary abdominal closure, performing visceral resections just in case of gangrenous tracts and providing for a "secondlook" during the variable period of resuscitation and vacuum assisted dressing. RESULTS: A non-occlusive mesentheric @entity1 with diffuse visceral underperfusion was confirmed in every case. Temporary abdominal closure was applied to treat @entity3 in every case, 13 @entity0 required associated resection of gangrenous tracts (50%). Seventeen @entity0 died following first operation as a consequence of @entity2 (65.4%). Nine @entity0 survived (34.6%) and underwent re-establishment of intestinal continuity and definitive closure of abdominal wall within 30 DAYS. DISCUSSION AND CONCLUSIONS: @entity1 occuring after cardiac surgery is associated with an increase of intra-abdominal pressure and subsequent @entity3 . Basing on this case series, an early @entity3 treatment using open abdomen techniques may be results in a better outcome of critically injured cardiac @entity0 . These results compared favourably with literature experiences (mortality rate > 85%). KEY WORDS: @entity3 , @entity1 , Cardiac surgery.

title: Acute mesenteric ischemia after cardiac surgery. Role of the XXXX treatment.

answer: @entity3


abstract: BACKGROUND: High-throughput sequencing (HTS) analysis of microbial communities from the respiratory airways has heavily relied on the 16S rRNA gene. Given the intrinsic limitations of this approach, airway microbiome research has focused on assessing bacterial composition during health and disease, and its variation in relation to clinical and environmental factors, or other microbiomes. Consequently, very little effort has been dedicated to describing the functional characteristics of the airway microbiota and even less to explore the microbe-host interactions. Here we present a simultaneous assessment of microbiome and host functional diversity and host-microbe interactions from the same RNA-seq experiment, while accounting for variation in clinical metadata. METHODS: Transcriptomic (host) and metatranscriptomic (microbiota) sequences from the nasal epithelium of 8 @entity2 and 6 healthy controls were separated in silico and mapped to available @entity0 and NCBI-NR protein reference databases. @entity0 genes differentially expressed in @entity2 and controls were then used to infer upstream regulators involved in immune and inflammatory responses. Concomitantly, microbial genes were mapped to metabolic databases (COG, SEED, and KEGG) to infer microbial functions differentially expressed in @entity2 and controls. Finally, multivariate analysis was applied to find associations between microbiome characteristics and host upstream regulators while accounting for clinical variation. RESULTS AND DISCUSSION: Our study showed significant differences in the metabolism of microbiomes from asthmatic and non-asthmatic @entity0 for up to 25% of the functional properties tested. Enrichment analysis of 499 differentially expressed host genes for inflammatory and immune responses revealed 43 upstream regulators differentially activated in @entity1 . Microbial adhesion (virulence) and Proteobacteria abundance were significantly associated with variation in the expression of the upstream regulator @entity3 ; suggesting that microbiome characteristics modulate host inflammatory and immune systems during @entity1 .

title: Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in XXXX .

answer: @entity1


abstract: BACKGROUND: Several inflammatory cytokines play a key part in the induction of @entity4 . Until now, involvement of the Th2 cytokine @entity9 ( @entity9 ) in @entity4 hadn't yet been studied. @entity9 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as @entity6 , @entity1 and @entity7 , is now emerging. Given the important role of @entity9 in @entity2 , we measured its serum levels in postmenopausal @entity8 @entity0 . METHODS AND RESULTS: In fifty-six postmenopausal females with @entity4 and 26 healthy controls, bone mineral density (BMD) measurements were performed by using calcaneal quantitative ultrasound (QUS) technique, confirmed at the lumbar spine and hip by dual energy X-ray absorptiometry (DXA). Both @entity0 and controls were divided according to age (less or more than 65  years) and disease severity (T-score levels and presence of @entity5 ). Serum @entity9 levels were measured by ELISA technique. @entity8 @entity0 exhibited elevated levels of serum @entity9 compared with healthy controls (43.12        6.97 vs 29.58        6.09  pg/ml; p   <   0.049). @entity9 expression was higher in over 65  years old @entity0 compared to age-matched controls (45        11.05 vs. 17.92        5.92; p   <   0.01), whereas in younger subjects no statistically significant differences were detected between @entity0 and controls (37.91        6.9 vs 32.08        8.2). No statistically significant differences were found between @entity9 levels in @entity0 affected by mild (T-score   >   -3) compared to severe (T-score   <   -3) @entity4 (59.17        9.22 vs 37.91        10.52), neither between @entity5 and @entity8 @entity0 (33.75        9.16 vs 51.25        8.9). CONCLUSIONS: We showed for the first time an increase of @entity9 serum levels in postmenopausal @entity0 with @entity3 . Although they did not reflect the severity of @entity4 and/or the presence of @entity5 , they clearly correlated with age, as reflected by the higher levels of this cytokine in aged @entity0 .

title: Increased levels of @entity9 ( @entity9 ) in XXXX .

answer: @entity4


abstract: OBJECTIVE: The present study aims to evaluate changes in proteomic salivary profile of @entity0 with @entity4 after @entity1 treatments. MATERIALS AND METHODS: Samples were collected from @entity0 after @entity1 therapies, and were analyzed by means of SELDI/ @entity3 . @entity0 were separated in two groups: @entity0 affected by @entity2 ( @entity2 ) and @entity0 without @entity2 (NO @entity2 ). All @entity0 were divided in function of the anticancer treatment: @entity0 who had radiotherapy ( @entity2 RADIO), had not radiotherapy ( @entity2 NO RADIO), had chemotherapy ( @entity2 CHEMO) and those who had not chemotherapy ( @entity2 NO CHEMO). Statistical evaluation PCA (Principal Component Analysis), was conducted with the software BIO-RAD Data Manager (   ) (Version 3.5). RESULTS: We found the increased peaks of 3443, 3487, 4135 m/z in @entity2 group, while 6237 m/z was reduced. The same peaks would the same modifications in @entity2 RADIO, while in @entity2 CHEMIO are increased 3443 and 6237 m/z but 3487, 4135 m/z are reduced. These data were confirmed by the Principal Component Analysis (PCA). CONCLUSION: Anticancer therapy influenced the level expression of many salivary biomarkers in @entity2 with a good significance. Therefore 3443, 3487, 4135 and 6237 m/z are good biomarker candidates of @entity4 . This article is protected by copyright. All rights reserved.

title: Expression of salivary biomarkers in @entity0 with XXXX : evaluation by SELDI- @entity3 /MS.

answer: @entity4


abstract: Influence of excessive intake of @entity3 (AA) on @entity1 induced @entity2 was investigated. In the present study four groups of male @entity4 were maintained for 30 days as follows: (1) Control group (1 mg AA/100 g body wt). (2) @entity5 group (I mg AA + 9 g @entity5 /100 g body wt). (3) AA group (25 mg AA/100 g body wt). (4) AA + @entity5 group (25 mg AA/100 g body wt + 9 g @entity5 100 g body wt). It was shown that tissue @entity3 concentration increased with the intake of mega dose of AA. @entity1 administration depleted tissue @entity3 content. But coadministration of AA and @entity1 enhanced AA levels in comparison with the @entity5 group. @entity1 induced @entity2 was reduced in almost all the tissues by the intake of @entity3 . This was observed to be due to increased hepatic catabolism of @entity0 to @entity6 . However cholesterogenesis was enhanced as evidenced by the increased HMG CoA activity. Thus the results indicate that the mega dose of AA ingestion is beneficial in reducing @entity1 induced @entity2 and @entity7 .

title: Interaction of @entity5 and @entity3 on lipid metabolism in XXXX .

answer: @entity4


abstract: Matrix metalloproteinases (MMPs) are @entity4 dependent endopeptidases implicated in @entity3 invasion and @entity2 . Gelatin zymography was performed on 84 @entity1 @entity0 and seven normal breast tissues. The precursor form of @entity5 (72 kDa) was found in 11 (12%) samples, while its two activated forms, i.e. 62 kDa and 59 kDa, were found in three (6%) and 34 (40%) samples respectively. In contrast to @entity5 , most of the samples (52%) contained @entity6 in its precursor form. Using ELISA, @entity8 levels were found in 12% of the samples while @entity7 levels were found in only 2% of the samples. Levels of @entity5 correlated inversely with numbers of nodal metastases. Neither @entity9 levels were significantly related to @entity1 outcome. However, @entity1 with high levels of a 50-kDa gelatinase band after zymography had a significantly better survival than @entity1 with low levels. This species was never observed in normal breast tissue.

title: Assay of matrix metalloproteinases types 1, 2, 3 and 9 in XXXX .

answer: @entity0


abstract: A recessive single gene mutant, 7B-1, in @entity1 was originally selected for its photoperiod-dependent male sterility. The 7B-1 mutant also has some pleiotropic effects including reduced light-induced inhibition, i.e. de-etiolation, of the hypocotyl in long days (LD), increased seed size and weight, and reduced transpiration rate. These traits led us to investigate the sensitivity of 7B-1 to exogenous hormones and the interaction of these responses with daylength. In LD, but not in short days (SD), 7B-1 was more sensitive than wild-type (WT) to exogenous @entity2 ( @entity3 ) for inhibition of seed germination, root elongation and transpiration rate. 7B-1 mutant also exhibited reduced responses to exogenous @entity4 (GA(3)) for hypocotyl elongation, and to inhibitors of GA biosynthesis for seed germination and root and hypocotyl elongation. 7B-1 hypocotyls contained a higher level of endogenous @entity3 than WT in both photoperiods, although @entity3 levels were higher in LD than in SD. In contrast, growth-active GAs, i.e. GA(1), GA(3) and GA(4), and IAA were low in the mutant hypocotyls. The 7B-1 mutant appears to be an @entity3 -overproducer, and the photoperiod-regulated @entity3 levels may be responsible for the @entity0 of the mutant to exogenous @entity3 .

title: Reduced de-etiolation of hypocotyl growth in a @entity1 mutant is associated with XXXX to, and high endogenous levels of, @entity2 .

answer: @entity0


abstract: We report a case of @entity13 in a 20-year-old @entity0 diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred @entity4 that had persisted for 1 month. He also noted @entity2 , @entity5 , and @entity7 in the lower extremities around the same time. The visual acuity of his right and left eye was 20/40 and 20/20, respectively. @entity12 and @entity10 were present. Brain magnetic resonance imaging showed no @entity9 , while elevated cerebrospinal fluid pressure, reduced nerve conduction velocity in both lower extremities, @entity8 , M proteinemia, high blood @entity1 levels, osteoblastic and osteolytic changes in the spine, and atypical plasma cells in @entity3 were noted. From the above findings, the @entity0 was diagnosed with @entity13 . He received high-dose @entity6 , @entity11 , and radiotherapy on the sacral mass, followed by high-dose melphalan with autologous stem-cell support, and showed subsequent systemic and ophthalmologic improvement. Here, we report the youngest case ever of @entity13 with @entity14 . If @entity0 have @entity12 in both eyes with no intracranial space-occupying lesion, @entity13 should be considered in differential diagnosis, regardless of age.

title: POEMS Syndrome in a 20-year-old XXXX Diagnosed Following a Complaint of Reduced Visual Acuity.

answer: @entity0


abstract: OBJECTIVE: Weight assessment is a critical aid in @entity0 care. It is particularly important in monitoring progression of pregnancies, @entity3 status, and when adjusting medications. Although weight is generally determined using a scale, few studies have evaluated the precision of non-household scales. The objective of this study was to assess scale precision across a variety of settings. METHODS: An evaluation of scales from randomly selected primary care clinics (n=30), diabetology/endocrinology clinics (n=7), @entity1 facilities (n=25), and @entity2 centers (n=30) was performed. Assessments were completed on a total of 223 scales: 94 from primary care clinics, 32 from diabetology/endocrinology clinics, 39 from @entity1 centers, and 58 from @entity2 centers. Scales were assessed for condition, location in facility, resting surface, commercial designation, and calibration history. Scale precision was validated using 100 lb. (45.5 kg), 150 lb. (68.3 kg), 200 lb. (90.9 kg), and 250 lb. (113.6 kg) certified weights. RESULTS: Overall, scales demonstrated decreased precision with increased weight. At higher weights, more than 15% of scales were off by more than 6 lbs. (2.3 kg), approximately 1 Body Mass Index (BMI) unit. While facility type was not significant, condition, location in facility, resting surface, commercial designation, and calibration history were significant. CONCLUSIONS: This study demonstrates that many scales used to measure body weight are imprecise and that scales in health care settings are no more precise than those in other facilities. Clinical decisions based on scales that are imprecise have the potential to cause iatrogenic complications in @entity0 care.

title: Precision in weighing: a comparison of scales found in physician offices, XXXX centers, and @entity1 centers.

answer: @entity2


abstract: BACKGROUND: Despite the fact that new drugs have emerged from clinical research in @entity1 during the last decade, the prognosis of @entity0 with @entity10 remains poor with a median survival of 12 to 14 months. We designed a feasibility study of @entity3 and @entity5 (GO) in @entity0 with advanced @entity1 . @entity0 AND METHODS: Twenty @entity0 received bimonthly cycles of @entity3 1500 mg/m2 and @entity5 85 mg/m2. The cycles were given at 2-week intervals without @entity7 support. Thirteen @entity0 were treated with the GO combination as first-line chemotherapy because of a poor performance status or a @entity6 clearance < 1 ml/s. RESULTS: The median number of cycles of GO was 5 (1-7). The median number of days between cycles was 14 throughout the treatment. Seven (8%) out of 87 cycles had to be delayed because of @entity9 or @entity8 . A 25% dose reduction in the doses of cytotoxic drugs was necessary in 2 @entity0 . Chemotherapy was stopped before the sixth cycle because of an early death related to a @entity4 in 1 @entity0 , a grade 3 @entity2 in 1 @entity0 and a progressive disease in 9 @entity0 . CONCLUSION: Using these doses and schedules, the GO regimen appears a safe therapy for @entity0 with advanced @entity1 . Phase II studies are required to assess the possible role of this combination in advanced @entity1 .

title: XXXX and @entity5 in advanced transitional cell carcinoma of the urothelium: a pilot study.

answer: @entity3


abstract: OBJECTIVE: Pharmacological treatments for @entity7 and @entity2 in @entity0 with @entity3 have shown limited efficacy. The authors assessed the heterogeneity of response to @entity5 in the @entity5 for Agitation in @entity3 (CitAD) study to identify individuals who may be helped or harmed. METHOD: In this double-blind parallel-group multicenter trial of 186 @entity0 with @entity3 and clinically significant @entity7 , @entity0 were randomly assigned to receive @entity5 or placebo for 9 weeks, with the dosage titrated to 30 mg/day over the first 3 weeks. Five planned potential predictors of treatment outcome were assessed, along with six additional predictors. The authors then used a two-stage multivariate method to select the most likely predictors; grouped @entity0 into 10 subgroups by their index scores; and estimated the @entity5 treatment effect for each. RESULTS: Five covariates were likely predictors, and treatment effect was heterogeneous across the subgroups. @entity0 for whom @entity5 was more effective were more likely to be outpatients, have the least @entity1 , have moderate @entity7 , and be within the middle age range (76-82 years). @entity0 for whom placebo was more effective were more likely to be in long-term care, have more severe @entity1 , have more severe @entity7 , and be treated with @entity8 . CONCLUSIONS: Considering several covariates together allowed the identification of responders. Those with moderate @entity7 and with lower levels of @entity1 were more likely to benefit from @entity5 , and those with more severe @entity7 and greater @entity1 were at greater risk for adverse responses. Considering the dosages used and the association of @entity5 with @entity6 , use of this agent to treat @entity7 may be limited to a subgroup of @entity0 with @entity4 .

title: Heterogeneity of Treatment Response to XXXX for @entity0 With @entity3 With Aggression or Agitation: The CitAD Randomized Clinical Trial.

answer: @entity5


abstract: UNASSIGNED: The lateral line found in some amphibians and fishes has two distinctive classes of sensory organs: mechanoreceptors (neuromasts) and electroreceptors (ampullary organs). Hair cells in neuromasts can be damaged by @entity3 antibiotics and they will regenerate rapidly afterward. @entity3 sensitivity and the capacity for regeneration have not been investigated in ampullary organs. We treated @entity5 ( @entity5 ) larvae with @entity2 and observed loss and regeneration of sensory hair cells in both organs by labeling with DASPEI and @entity1 ( @entity1 ). The numbers of sensory hair cells in both organs were reduced to the lowest levels at 6 hours post-treatment (hpt). New sensory hair cells began to appear at 12 hpt and were regenerated completely in 7 days. To reveal the possible mechanism for ampullary hair cell regeneration, we analyzed cell proliferation and the expression of neural placodal gene eya1 during regeneration. Both cell proliferation and eya1 expression were concentrated in peripheral mantle cells and both increased to the highest level at 12 hpt, which is consistent with the time course for regeneration of the ampullary hair cells. Furthermore, we used Texas Red-conjugated @entity0 in an uptake assay following pre-treatment with a cation channel blocker ( @entity4 ) and found that entry of the antibiotic was suppressed in both organs. Together, our results indicate that ampullary hair cells in @entity5 larvae can be damaged by @entity2 exposure and they can regenerate rapidly. We suggest that the mechanisms for @entity3 uptake and hair cell regeneration are conserved for mechanoreceptors and electroreceptors. This article is protected by copyright. All rights reserved.

title: @entity2 Damage and Regeneration of Hair Cells in Both Mechanoreceptor and Electroreceptor Lateral Line Organs of the Larval @entity5 ( XXXX ).

answer: @entity5


abstract: @entity11 ( @entity11 ) accounts for 15-20% of all autopsy confirmed @entity5 in old age. Characteristic histopathological changes are intracellular @entity11 and Lewy neurites, with abundant senile plaques but sparse neurofibrillary tangles. Core clinical features are fluctuating @entity3 , persistent @entity12 and @entity1 ( @entity6 ). One of these core features has to be present for a diagnosis of possible @entity11 , and two for probable @entity11 . Supportive features are repeated falls, @entity10 , transient @entity8 , @entity13 , delusions and @entity12 in other modalities. @entity11 is clinically under-diagnosed and frequently misclassified as systemic @entity9 or @entity5 due to @entity4 or @entity2 . Therapeutic approaches to @entity11 can pose difficult dilemmas in pharmacological management. Neuroleptic medication is relatively contraindicated because some @entity0 show severe @entity13 , which is associated with increased morbidity and mortality. Antiparkinsonian medication has the potential to exacerbate @entity7 symptoms and may be relatively ineffective at relieving @entity1 . Recently there is converging evidence that treatment with cholinesterase inhibitors can offer a safe alternative for the symptomatic treatment of cognitive and neuropsychiatric features in @entity11 . This review will focus on the clinical characteristics of @entity11 , its differential diagnosis and on possible management strategies.

title: XXXX with lewy bodies--diagnosis and treatment.

answer: @entity5


abstract: OBJECTIVE: The present study aims to evaluate changes in proteomic salivary profile of @entity0 with @entity4 after @entity1 treatments. MATERIALS AND METHODS: Samples were collected from @entity0 after @entity1 therapies, and were analyzed by means of SELDI/ @entity3 . @entity0 were separated in two groups: @entity0 affected by @entity2 ( @entity2 ) and @entity0 without @entity2 (NO @entity2 ). All @entity0 were divided in function of the anticancer treatment: @entity0 who had radiotherapy ( @entity2 RADIO), had not radiotherapy ( @entity2 NO RADIO), had chemotherapy ( @entity2 CHEMO) and those who had not chemotherapy ( @entity2 NO CHEMO). Statistical evaluation PCA (Principal Component Analysis), was conducted with the software BIO-RAD Data Manager (   ) (Version 3.5). RESULTS: We found the increased peaks of 3443, 3487, 4135 m/z in @entity2 group, while 6237 m/z was reduced. The same peaks would the same modifications in @entity2 RADIO, while in @entity2 CHEMIO are increased 3443 and 6237 m/z but 3487, 4135 m/z are reduced. These data were confirmed by the Principal Component Analysis (PCA). CONCLUSION: Anticancer therapy influenced the level expression of many salivary biomarkers in @entity2 with a good significance. Therefore 3443, 3487, 4135 and 6237 m/z are good biomarker candidates of @entity4 . This article is protected by copyright. All rights reserved.

title: Expression of salivary biomarkers in XXXX with @entity4 : evaluation by SELDI- @entity3 /MS.

answer: @entity0


abstract: BACKGROUND: Bloodstream infections in @entity3 @entity0 are associated with mortality as high as 60% and a prolonged hospital stay. We evaluated the impact of @entity5 ( @entity5 ) in a @entity3 . METHODS: This retrospective study evaluated adults with intensive care unit admission greater than 72  hours and @entity1 . Two groups were evaluated: appropriate antibiotic therapy (AAT) vs @entity5 . RESULTS: In 72 episodes of @entity1 , 57 (79%) AAT and 15 (21%) @entity5 , mean age was 54    17  years and APACHE II of 17    8. Time to appropriate antibiotics was longer for @entity5 (3    5 @entity5 vs 1    1 AAT days, P = .003). @entity5 was seen primarily with Acinetobacter spp (33% @entity5 vs 9% AAT, P = .01) and @entity4 (26% @entity5 vs 7% AAT, P = .03). If 2 or more @entity2 occurred, Acinetobacter spp. was more likely, 32% vs 2%, P = .001. CONCLUSIONS: AAT selection is imperative in critically @entity0 with @entity1 to reduce the significant impact of inappropriate selection. Repeated episodes of @entity1 should receive special attention.

title: Impact of inappropriate initial antibiotics in @entity3 surgical XXXX with @entity1 .

answer: @entity0


abstract: @entity5 ( @entity5 ) of the pancreas is extremely rare. Although the diagnosis of @entity5 is suggested by the light microscopic appearance of the @entity2 , it should be confirmed by the immunohistochemical evaluation of the @entity3 expression and if possible, further determination of the particular chromosome translocation, t(11;22)(q24,q12). In this report, we present a male @entity0 with pancreatic @entity6 who had been followed up for 50 months. The related literature is also reviewed. In our case, the pathologic diagnosis was based on the positive immunoreactivity for @entity4 in many of the @entity2 cells. The complementary cytogenetic studies were not possible in the private setting of the @entity0 's treatment. The @entity0 was 31 years old when first operated. Within 4 months of the first operation he had local recurrence. In the third year of his follow-up he had been discovered to have pulmonary metastases and another @entity1 in his lung was diagnosed the year after. The metastatic foci were primarily treated by surgical resections. He had chemotherapy after each resection of pulmonary metastatic foci. After 50 months of the initial surgical intervention, he succumbed to widespread thoracic and bone metastases. Because of the extreme rarity of @entity6 in the pancreas, and its rather protracted course, we think our case may further contribute to the ever expanding database for this particular entity.

title: XXXX . A case report of an extremely rare @entity2 .

answer: @entity5


abstract: UNASSIGNED: Few studies have examined the clinical characteristics of @entity0 with lesions in the deep parietal operculum facing the sylvian fissure, the region recognized as the secondary somatosensory area (SII). Moreover, surgical approaches in this region are challenging. In this paper the authors report on a @entity0 presenting with @entity5 with a @entity1 in the left deep parietal operculum. The @entity0 was a 24-year-old @entity0 who suffered daily partial @entity6 with extremely uncomfortable @entity7 and/or occasional @entity4 on his right side. MRI revealed a @entity1 in the medial aspect of the anterior transverse parietal gyrus, surrounding the posterior insular point. Long-term video electroencephalography monitoring with scalp electrodes failed to show relevant changes to @entity6 . Resection with cortical and subcortical mapping under awake conditions was performed. A negative response to stimulation was observed at the subcentral gyrus during language and somatosensory tasks; thus, the transcortical approach (specifically, a transsubcentral gyral approach) was used through this region. Subcortical stimulation at the medial aspect of the anterior parietal gyrus and the posterior insula around the posterior insular point elicited strong @entity7 and @entity4 in his right side, similar to manifestation of his @entity6 . The @entity1 was completely removed and pathologically diagnosed as @entity8 . His @entity5 disappeared without @entity2 postoperatively. In this case study, 3 points are clinically significant. First, the clinical manifestation of this case was quite rare, although still representative of @entity5 . Second, the location of the lesion made surgical removal challenging, and the transsubcentral gyral approach was useful when intraoperative mapping was performed during awake surgery. Third, intraoperative mapping demonstrated that the @entity0 experienced @entity4 with electrical stimulation around the posterior insular point. Thus, this report demonstrated the safe and effective use of the transsubcentral gyral approach during awake surgery to resect deep parietal @entity3 , clarified electrophysiological characteristics in the SII area, and achieved successful @entity1 resection with good control of @entity5 .

title: A case of secondary @entity5 with a left deep parietal opercular lesion: successful XXXX resection using a transsubcentral gyral approach during awake surgery.

answer: @entity1


abstract: UNASSIGNED: Strains of the @entity0 @entity0 group have been extensively studied because some are used as probiotics in foods. Conversely, their phages have received much less attention. Here we analyze the complete genome sequence of five @entity1 temperate phages, CL1, CL2, iLp84, iLp1308 and iA2. Only phage iA2 could not replicate in an indicator strain. Genome length varied from 34,155 bp (iA2) to 39,474 bp (CL1). Phages iA2 and iLp1308 (34,176 bp) possess the smallest genomes reported, so far, for phages of the @entity0 group. The GC content of the five ranged from 44.8% to 45.6%. As observed with many other phages, their genome was organized as follows: genes coding for DNA packaging - morphogenesis - lysis - lysogeny - replication. Phages CL1, CL2 and iLp1308 are highly related to each other. Phage iLp84 was also related to these three phages but the similarities were limited to gene products involved in DNA packaging and structural proteins. Genomic fragments of phages CL1, CL2, iLp1308 and iLp84 were found in several genomes of @entity0 strains. Prophage iA2 is unrelated to these four phages but almost all of its genome was found in at least four @entity0 strains. Overall, these phages are distinct from previously characterized @entity0 phages. Our results highlight the diversity of @entity0 phages and indicate frequent DNA exchanges between phages and their hosts.

title: Genomic diversity of phages infecting probiotic strains of XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity8 ( @entity11 ) is a neurotherapeutic drug prescribed for @entity5 , @entity3 and @entity10 , including @entity0 of reproductive age. @entity11 is a well-known teratogen that produces @entity6 in many organs including the nervous system, as well as @entity4 , including @entity7 and @entity9 . In developing brain, few studies have examined @entity11 effects on glial cells, particularly astrocytes. To investigate effects on primary glial precursors, we developed new cell culture and in vivo models using frontal cerebral cortex of postnatal day (P2) @entity1 . In vitro, @entity11 exposure elicited dose-dependent, biphasic effects on DNA synthesis and proliferation. In vivo @entity11 (300 mg/kg) exposure from P2 to P4 increased both DNA synthesis and cell proliferation, affecting primarily astrocyte precursors, as >75% of mitotic cells expressed brain lipid-binding protein. Significantly, the consequence of early @entity11 exposure was increased astrocytes, as both @entity14 + cells and glial fibrillary acidic protein were increased in adolescent brain. Molecularly, @entity11 served as an HDAC inhibitor in vitro and in vivo, as enhanced proliferation was accompanied by increased histone acetylation whereas it elicited changes in culture in cell-cycle regulators, including @entity15 , and cyclin-dependent kinase (CDK) inhibitors, @entity13 and @entity12 . Collectively, these data suggest clinically relevant @entity11 exposures stimulate glial precursor proliferation, though at higher doses can elicit inhibition through differential regulation of CDK inhibitors. Because changes in glial cell functions are proposed as mechanisms contributing to @entity2 , these observations suggest @entity11 teratogenic actions may be mediated through changes in astrocyte generation during development. This article is protected by copyright. All rights reserved.

title: @entity8 stimulates proliferation of glial precursors during cortical gliogenesis in developing XXXX .

answer: @entity1


abstract: AIM: Despite the reported occurrence of @entity4 of @entity3 , little is known about their prevalence in @entity0 from Northern Finland with @entity3 . The aim was to investigate the prevalence of @entity4 among @entity0 with different types of clefts in Northern Finland. MATERIALS AND METHODS: Design and Statistics: @entity0 records of 139 subjects aged three years and older (with clefts treated in Oulu University Hospital, Finland during the period 1996-2010 (total n. 183) were analysed for @entity4 including the number of teeth, morphological @entity2 and their association with the cleft type. The analyses were carried out using Chi-square test and Fisher's exact test. Differences between the groups were considered statistically significant at p values < 0.05. RESULTS: More than half of the @entity0 had clefts of the hard palate, 18% of the lip and palate, and 13% of the lip. At least one @entity4 was detected in 47% of the study population. Almost one in three (26.6%) subjects had at @entity1 and 17.9% had two or three anomalies. The most common @entity1 in permanent teeth were missing teeth followed by supernumerary teeth. Supernumerary teeth were significantly more apparent when the lip was involved in the cleft compared with palatal clefts. Missing teeth were less prevalent among those 5 years or younger. The prevalence of different anomalies was significantly associated with the cleft type in both age groups. CONCLUSIONS: @entity4 are more prevalent among cleft @entity0 than in the general population in Finland. The most @entity1 associated with cleft were missing and supernumerary teeth.

title: @entity4 associated with XXXX in Northern Finland.

answer: @entity3


abstract: The objective of this study was to describe the exposure to non-corticosteroid treatments in adult primary @entity2 ( @entity2 ) @entity0 before the chronic phase at a nationwide level. Study population is derived from the 2009-2011 cohort of the French Adult Immune @entity1 : a French pHarmacoepidemiological study (FAITH, no. ENCEPP 4574). The FAITH cohort includes all incident and persistent or chronic adult primary @entity2 @entity0 treated in France. It was built through the nationwide French health insurance database, called SNIIRAM. For the present study, we included FAITH @entity0 who were followed by at least 12months and who had at least one exposure to a non-corticosteroid treatment before the @entity2 chronic phase. Exposure to non-corticosteroid treatments was searched through in- and out-hospital dispensing. Predictors of the choice among first-line non-corticosteroid treatments (rituximab, splenectomy or other drugs) were studied using a multinomial regression. The study population included 443 @entity0 . Non-corticosteroid treatments used in more than 10% of the @entity0 at any time before the chronic phase were: rituximab (57.8%), splenectomy (22.1%), TPO-RAs (16.8%), repeated intravenous immunoglobulin (IVIg) courses (15.0%), danazol (14.4%) and dapsone (10.8%). Rituximab was the most used first-line non-corticosteroid treatment (45.4%). TPO-RAs and dapsone were more frequently used after 65years of age (respectively, 24.8% versus 12.8%, p=0.01 and 17.6% versus 7.2%, p=0.0008), unlike splenectomy (16.4% versus 25.2%, p=0.03). Age over 65years was the sole independent predictor of first-line non-corticosteroid treatment choice. In conclusion, rituximab was the leading non-corticosteroid treatment used before the chronic phase. TPO-RAs were mainly used in accordance with their labeling. IVIgs were consistently used as a chronic non-corticosteroid treatment.

title: Exposure to non-corticosteroid treatments in adult primary XXXX before the chronic phase in the era of thrombopoietin receptor agonists in France. A nationwide population-based study.

answer: @entity2


abstract: The aim of the present work was to study @entity1 among school age students suffering from @entity2 . The study was conducted on a total number of 146 @entity3 preparatory school students, attending the @entity2 clinic in Sporting Students' Hospital in Alexandria Governorate. The study was performed during the period from June to September 1997. A matching control of 223 non- @entity3 students from the preparatory school in the East educational zone in Alexandria Governorate were also included in the study. The study was carried out through a cross-sectional approach. A structured self-administered questionnaire was used to collect data about, the general characteristics of the sample, interpersonal and inter-parental relationships, school performance and the attitude and behavior of mothers towards their @entity3 @entity0 . The Arabic version of State-Trait @entity1 Inventory (STAI) was used to identify @entity0 with @entity1 state. The present result revealed that 24.7% of the @entity3 students were anxious, with a higher preponderance among @entity0 than @entity0 (26.6%, 21.2%, respectively). Bad interpersonal and inter-parental relationships had increased the risk of occurrence of @entity1 state among @entity3 @entity0 . Also, poor scholastic achievement was more encountered among @entity3 who had @entity1 . The development of @entity2 education programs to increase parents', @entity0 's and teachers' awareness of @entity2 symptoms and @entity2 trigger events was recommended.

title: @entity1 among school age @entity0 suffering from XXXX .

answer: @entity2


abstract: BACKGROUND: A collateral circulation which supplies a myocardial territory, subtended by a chronic total occlusion (CTO), may be observed at invasive coronary angiography. The prognostic and protective role of such collateralisation is well demonstrated suggesting that a good collateral circulation may be a predictor of @entity3 , but current evidence is discrepant. The aim of this study is to assess the relationship between collateralisation from the @entity3 by cardiovascular magnetic resonance (CMR). METHOD: Consecutive @entity0 with CTO having had both CMR and invasive coronary angiography were retrospectively identified. The collateral circulation was graded with the Cohen and Rentrop classification. CMR images were graded per segment for wall motion (1: normal/ @entity2 , 2: hypokinetic, 3: @entity5 , or 4: dyskinetic) and wall motion score index (WMSI) was calculated. The segmental transmurality of late @entity4 enhancement was scored as 1 (0%), 2 (1-25%), 3 (26-50%), 4 (51-75%) and 5 (76-100%). RESULTS: A good collateral circulation was more likely to supply viable myocardium (p=0.01). There was no relationship between collateral circulation supply and wall motion score index (WMSI), however, increasing transmurality of LGE was significantly associated with higher mean WMSI representing increasing dysfunctional myocardium (p<0.001). CONCLUSION: The presence of collateral coronary circulation at angiography predicts the presence of @entity1 , with a gradation of greater viability associated with improving Rentrop grade. A collateral circulation at angiography should, therefore, prompt more formal assessment of viability and consideration of revascularisation in order for the @entity0 to obtain the associated functional and prognostic improvement.

title: The relationship between the contralateral collateral supply and XXXX on cardiovascular magnetic resonance: Can the angiogram predict functional recovery?

answer: @entity3


abstract: BACKGROUND: We sought to assess the impact of @entity3 (18)F-fluoro-ethyl-tyrosine (FET) positron emission tomography (PET) on the volumetric target definition for radiation therapy of high-grade @entity2 versus the current standard using MRI alone. Specifically, we investigated the influence of @entity1 grade, MR-defined @entity1 volume, and the extent of surgical resection on PET positivity. METHODS: Fifty-four consecutive high-grade @entity2 @entity0 (World Health Organization grades III-IV) with confirmed histology were scanned using FET-PET/CT and T1 and T2/fluid attenuated inversion recovery MRI. Gross @entity1 volume and clinical target volumes (CTVs) were defined in a blinded fashion based on MRI and subsequently PET, and volumetric analysis was performed. The extent of the surgical resection was reviewed using postoperative MRI. RESULTS: Overall, for    90% of the @entity0 , the PET-positive volumes were encompassed by T1 MRI with contrast-defined @entity1 plus a 20-mm margin. The @entity1 volume defined by PET was larger for @entity2 grade IV (P < .001) and smaller for @entity0 with more extensive surgical resection (P = .004). The margin required to be added to the MRI-defined @entity1 in order to fully encompass the FET-PET positive volume tended to be larger for grade IV @entity1 (P = .018). CONCLUSION: With an unchanged CTV margin and by including FET-PET for gross @entity1 volume definition, the CTV will increase moderately for most @entity0 , and quite substantially for a minority of @entity0 . @entity0 with grade IV @entity2 were found to be the primary candidates for PET-guided radiation therapy planning.

title: Impact of [18F]-fluoro-ethyl-tyrosine PET imaging on target definition for radiation therapy of high-grade XXXX .

answer: @entity2


abstract: BACKGROUND: Anaesthetic drugs act at sites within the brain that undergo profound changes during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in the EEG change with age. METHODS: We analysed the EEG in 155 @entity0 aged 18-90 yr who received @entity1 (n=60) or @entity2 (n=95) as the primary anaesthetic. The EEG spectrum and coherence were estimated throughout a 2 min period of stable anaesthetic maintenance. Age-related effects were characterized by analysing power and coherence as a function of age using linear regression and by comparing the power spectrum and coherence in young (18- to 38-yr-old) and elderly (70- to 90-yr-old) @entity0 . RESULTS: Power across all frequency bands decreased significantly with age for both @entity1 and @entity2 ; elderly @entity0 showed EEG oscillations    2- to 3-fold smaller in amplitude than younger adults. The qualitative form of the EEG appeared similar regardless of age, showing prominent alpha (8-12 Hz) and slow (0.1-1 Hz) oscillations. However, alpha band dynamics showed specific age-related changes. In elderly compared with young @entity0 , alpha power decreased more than slow power, and alpha coherence and peak frequency were significantly lower. Older @entity0 were more likely to experience burst suppression. CONCLUSIONS: These profound age-related changes in the EEG are consistent with known neurobiological and neuroanatomical changes that occur during typical ageing. Commercial EEG-based depth-of-anaesthesia indices do not account for age and are therefore likely to be inaccurate in elderly @entity0 . In contrast, monitoring the unprocessed EEG and its spectrogram can account for age and individual @entity0 characteristics.

title: The Ageing Brain: Age-dependent changes in the electroencephalogram during XXXX and @entity2 general anaesthesia.

answer: @entity1


abstract: PURPOSE: Traditional Kasai portoenterostomy and porto-appendiceal duodenostomy have been utilized for @entity2 . Differences in outcome between @entity0 who underwent either Kasai portoenterostomy or porto-appendiceal duodenostomy were compared. METHODS: A review of all @entity0 who underwent a drainage procedure for @entity2 from 1986 to 2000 (n = 30) was performed. Age at drainage procedure, subsequent liver transplantation, and outcomes were evaluated. Outcome variables included success rates (total @entity1 < 2.0 mg/dL) and survival rate. Statistical analysis was done with chi2 and Student's t test. RESULTS: Long-term follow-up was available on 28 of 30 @entity0 . Age at biliary drainage was insignificant. Success rates between porto-appendiceal duodenostomy (31%) and Kasai portoenterostomy (82%) were statistically significant. Survival rate for @entity0 who underwent a Kasai portoenterostomy was 10 of 11 @entity0 . Survival rate for @entity0 who underwent porto-appendiceal duodenostomy was 14 of 16 @entity0 . Overall survival rate was comparable between porto-appendiceal duodenostomy (88%) and Kasai portoenterostomy (91%). CONCLUSIONS: Although overall survival rate was comparable, @entity0 who underwent porto-appendiceal duodenostomy were less successful in alleviating @entity3 compared with Kasai portoenterostomy. This is shown further by the greater incidence of subsequent liver transplantation in @entity0 with prior porto-appendiceal duodenostomy. Although the appendix may serve as an alternative biliary conduit, traditional Kasai portoenterostomy appears to achieve better biliary drainage.

title: Comparison of drainage techniques for XXXX .

answer: @entity2


abstract: OBJECTIVE: @entity2 are not common and carry different clinical features when compared with adults. To clarify the differences of aetiology and patterns of @entity2 in paediatric @entity0 , a clinical retrospective analysis was performed. @entity0 : One hundred seventy-four paediatric @entity0 younger than 16 years of age treated in the First Department of Oral and Maxillofacial Surgery, Osaka University Dental Hospital during a 15-year period were analysed. STUDY DESIGN: Age, sex, @entity2 patterns, incidence, common locations of the mandibular @entity2 and treatment were studied according to the @entity0 ' charts and radiographs. RESULTS: The ratio of @entity0 to @entity0 was 2:1 and the largest age subgroup was 15-years old. The most common cause of injury was bicycle accidents (26%), followed by falls (25%). The distribution of causes and ages revealed that the incidence of the fall-related @entity1 decreased in @entity0 older than 10 years, and assaults became a common cause in @entity0 older than 12 years. The yearly distribution showed a decrease of the group between 6 and 10 years and of bicycle-related accidents in the last 5-year period (1992-1996). @entity2 were most common (56%), followed by @entity2 (31%). Condylar @entity2 was common in @entity0 younger than 14 years, especially in those below 6 years. @entity2 of the mandibular angle were the most common in those above 13 years. CONCLUSION: These results document that the aetiological characters and patterns of paediatric maxillofacial @entity2 gradually shifted towards those found in adolescents.

title: XXXX : their aetiological characters and @entity2 patterns.

answer: @entity2


abstract: AIM: The application of @entity3 (S) is limited due to its @entity1 ; @entity8 ( @entity7 ) is a derivative of @entity3 . The aim was to employ @entity4 embryos to investigate and compare the developmental @entity1 induced by S and @entity7 . METHODS: The @entity1 of S and @entity7 was examined through the hatching rate and survival rate. Morphological changes of the @entity4 were observed with a dissecting microscope. Apoptosis was detected through @entity6 (AO) staining and flow cytometry. Apoptotic genes were measured by RT-PCR. RESULTS: Embryo @entity2 was observed in the embryos exposed to S at 200  mol  L(-1). When @entity7 concentration was increased to 1 mmol  L(-1), scoliolosis, and pericardial @entity0 could be seen in some embryos. Results from fluorescence microscopy and flow cytometry analysis showed that S at 200  mol  L(-1) induced apoptosis, whereas the apoptotic rate in the @entity7 -treated group (200  mol  L(-1)) was much lower than that in the S group. RT-PCR analysis showed that @entity5 mRNA expression and the ratio of @entity9 / @entity10 in the S group were significantly altered compared with the control group ((*)P < 0.05). Moreover, @entity9 mRNA expression in both S and @entity7 group were significantly different from that in the control group ((**)P <0.01). CONCLUSION: These results lead to the conclusion that @entity7 has significantly lower @entity1 than S in @entity4 embryos.

title: Toxic effects of @entity3 and XXXX on @entity4 embryos.

answer: @entity8


abstract: AIMS: In vitro studies have demonstrated that formation of reactive @entity1 species (ROS) contributes to the effect of bactericidal antibiotics. The formation of ROS is not restricted to bacteria, but also occurs in @entity0 cells. Oxidative stress is linked to several diseases. This study investigates whether antibiotic drugs induce oxidative stress in healthy @entity0 as a possible mechanism for adverse reactions to the antibiotic drugs. METHODS: This study contains information from two randomised, controlled trials. @entity0 underwent one-week treatment with @entity6 , @entity3 , @entity7 ( @entity7 ), or placebo. Oxidative modifications were measured as 24-hour urinary excretion of @entity8 ( @entity8 ), @entity9 ( @entity9 ), and plasma levels of @entity4 ( @entity5 ) before and after treatment as a measurement of DNA oxidation, RNA oxidation, and lipid peroxidation, respectively. RESULTS: @entity6 significantly increased urinary excretion of @entity8 by 22.0 % (95% CI: 3.6-40.4 %) and @entity9 by 14.9 % (95% CI: 3.7-26.1 %), which could be a possible mechanism to some of its adverse reactions. Further, we demonstrated that @entity3 significantly lowered urinary excretion of @entity8 by 21.7 % (95% CI: 5.8-37.6 %), but did not influence urinary excretion of @entity9 . @entity2 V did not influence urinary excretion of @entity8 or @entity9 . None of the antibiotic drugs influenced plasma levels of @entity5 . CONCLUSION: @entity6 significantly increases oxidative nucleic acid modifications. Increased oxidative modifications might explain some of @entity6 's known adverse reactions. @entity3 significantly lowers DNA oxidation but not RNA oxidation. @entity7 had no effect on oxidative nucleic acid modifications.

title: @entity6 , XXXX , and @entity2 and oxidative nucleic acid modifications in @entity0 : randomised, controlled trials.

answer: @entity3


abstract: This report describes a case of @entity7 into the bladder after repair of an @entity4 . Aortic repair consisted of resection of the @entity3 followed by prosthetic interposition to reestablish arterial continuity. During the postoperative period, the @entity0 had @entity1 of left colon, which was successfully treated by the Hartmann procedure. A right internal @entity5 measuring 50 mm in diameter was demonstrated by an abdominal CT scan during the initial hospitalization but was considered stable, since ultrasonography showed no change in diameter at 3 months and 1 year. The @entity0 was lost from follow-up until 3 years later when he was hospitalized after @entity2 of the right @entity5 , then measuring 120 mm in diameter, into the bladder. Surgical repair was undertaken. The procedure involved aortobifemoral bypass with suture of the @entity6 and branches of the internal iliac artery by the endoaneurysmal route. Postoperative recovery was uneventful. Upon reexamination 1 month after discharge from the hospital, the @entity0 was asymptomatic. This rare case confirms the gravity of internal @entity5 and the importance of therapeutic management to prevent @entity2 .

title: Rupture of internal @entity5 into the bladder following aortic XXXX repair.

answer: @entity3


abstract: PURPOSE: @entity7 has been associated with @entity3 , but its mechanisms have not been elucidated. The present study was designed to evaluate the role of @entity6 , a potent endogenous vasoconstrictor, in the genesis of @entity7 in @entity3 . METHODS: Our sample contained @entity0 with @entity5 (n = 43) and subjects with normal @entity4 and without acral @entity7 (n = 27). After the eligibility visit, all subjects underwent a provocative cooling test, consisting of wearing for 30 minutes a head-vest cooling garment containing coolant fluid. Blood was collected before and after cooling, and plasma @entity6 was determined by immunoassay. In addition, visual fields and retinal blood flow, measured with a confocal scanning laser and Doppler flowmeter, were measured before and after cooling. Peripheral finger flow, skin temperature, and blood pressure were monitored during the experiment. A recovery visit was performed within 1 month, when visual field and retinal blood flow measurements were repeated. RESULTS: Baseline plasma @entity6 levels were similar between @entity0 with @entity3 and control subjects (mean +/- SD: 2.81 +/- 1.29 and 2.56 +/- 1.36 pg/mL, respectively, P = 0.465). @entity0 with @entity3 , however, had a significant increase in plasma @entity6 after cooling (mean +/- SD increase of 34% +/- 52%, P = 0.001), not observed in control subjects (mean +/- SD increase of 7% +/- 43%, P = 0.750). No significant @entity2 was observed after cooling in either group. @entity0 with @entity3 who had evidence of acral @entity7 , however, were more likely to show @entity2 after cooling than @entity0 without acral @entity7 (P = 0.007). CONCLUSIONS: @entity0 with @entity3 have an abnormal increase in plasma @entity6 after the body cools. It is possible that at least in some @entity0 , increased levels of @entity6 in response to vasospastic stimuli may be involved in the pathogenesis of @entity1 .

title: Effects of cold-induced XXXX in @entity3 : the role of @entity6 .

answer: @entity7


abstract: UNASSIGNED: ABSTRACT Background: Recurrence of @entity1 ( @entity1 ) after surgical drainage is a significant problem with rates up to 20%. This study focuses on determining factors predictive of haematoma recurrence and presents a scoring system stratifying recurrence risk for individual @entity0 . Methods : Between the years 2005 and 2009, 331 consecutive @entity0 with @entity1 treated with surgery were included in this study. Univariate and multivariate analyses were performed searching for risk factors of increased post-operative haematoma volume and haematoma recurrence requiring repeat drainage. Results: We found a 12% reoperation rate. CSDH septation (seen on computed tomogram scan) was found to be an independent risk factor for recurrence requiring reoperation (p=0.04). Larger post-operative subdural haematoma volume was also significantly associated with requiring a second drainage procedure (p<0.001). Independent risk factors of larger post-operative haematoma volume included septations within a CSDH (p<0.01), increased pre-operative haematoma volume (p<0.01), and a greater amount of parenchymal atrophy (p=0.04). A simple scoring system for quantifying recurrence risk was created and validated based on @entity0 age (< or >= 80 years), haematoma volume (< or >= 160cc), and presence of septations within the subdural collection (yes or no). Conclusion: Septations within @entity1 are associated with larger post-operative residual haematoma collections requiring repeat drainage. When septations are clearly visible within a CSDH, craniotomy might be more suitable as a primary procedure as it allows greater access to a septated subdural collection. Our proposed scoring system combining haematoma volume, age, and presence of septations might be useful in identifying @entity0 at higher risk for recurrence.

title: Predicting Recurrence after XXXX Drainage.

answer: @entity1


abstract: BACKGROUND: Spinal fusion is a common orthopedic surgery in @entity0 and adolescents and is associated with high @entity1 levels postoperatively. If the @entity1 is not well managed, negative outcomes may ensue. To our knowledge, there is no measure in English that assesses @entity0 's satisfaction with postoperative @entity1 following idiopathic @entity3 surgery. The aim of the present study was to assess the psychometric properties of the satisfaction subscale of the English version of the Satisfaction of Adolescents with @entity2 management - idiopathic @entity3 ( @entity5 ) scale. METHODS: Eighty-two @entity0 aged 10-18 years, who had undergone spinal fusion surgery, fully completed the @entity5 scale at 10-14 days postdischarge. Construct validity was assessed through a principal component analysis using varimax rotation. RESULTS: Principal component analysis indicated a three-factor structure of the 13-item satisfaction subscale of the @entity5 scale. Factors referred to satisfaction regarding current medication received (Factor 1), actions taken by nurses and doctors to manage @entity1 ( @entity4 ) and information received after surgery (Factor 3). Cronbach's alpha was 0.91, showing very good internal consistency. Data on satisfaction and clinical outcomes were also reported. CONCLUSION: The @entity5 is a valid and reliable measure of satisfaction with postoperative @entity1 that can be used in both research and clinical settings to improve @entity1 practices. Although it was developed and validated with adolescents who had undergone spinal fusion surgery, it can be used, with further validation, to assess adolescents' satisfaction with @entity1 in other postoperative contexts.

title: Validation of the scale on Satisfaction of Adolescents with XXXX management - idiopathic @entity3 ( @entity5 ).

answer: @entity2


abstract: OBJECTIVES: With advancing age, the degree of dependency and occurrence of great @entity4 ( @entity4 ), also referred to as @entity5 , grow substantially. DESIGN: The prospective cohort study was aimed at conducting an analysis and @entity4 ( @entity5 ) among different age groups at admission to the acute geriatric department. SETTING, @entity0 : Between 1995 and 2012, we had altogether 12,210 elderly @entity0 at an average age of 80.5    7.0 y (range 65-103 y) hospitalised at the Department of Geriatrics. We divided the @entity0 set into three different age subgroups (65-74 y; 75-84 y and >=  85 y; e.g. 21.4 %; 47.9 % and 30.7 %) and compared the results among them. RESULTS: 3,787 @entity0 (31.0 %) were without any @entity4 . The growing tendency of the occurrence of all @entity4 in combinations with increased age (p < 0.001) is obvious. Their occurrence in the above mentioned different age sets was examined in relation to individual @entity4 and sex (female and male), namely falls 22.0 %, 27.8 %, 39.9 % and 20.5 %, 27.0 %, 36.1 %; immobility 26.4 %, 29.3 %, 42.5 % and 30.3 %, 30.1 % and 39.2 %; @entity3 38.4 %, 50.6 %, 69.5 % and 38.2 %, 47.4 %, 61.8 %; @entity2 and @entity1 13.4 %, 23.4 %, 38.1 % and 15.8 %, 24.3 %, 33.2 % respectively. Age cut-off for @entity4 occurrence based on ROC analysis is 83.5-84.5 y for females and 78.5-82.5 y for males. CONCLUSION: The occurrence of @entity5 increasing with age and female gender is of crucial importance not only for individuals and families but also for demands on costs of health and social care in oncoming decades (Tab. 6, Fig. 3, Ref. 52).

title: Geriatric giants - contemporary occurrence in 12,210 in- XXXX .

answer: @entity0