abstract: Studies in animals and @entity0 have demonstrated that an increased heart rate is a predictor for the development of @entity2 and overall cardiovascular mortality. In contrast, we have previously reported that the need for pacemaker implantation because of @entity4 in heart transplant recipients is associated with an increased prevalence of transplant @entity2 (TxCAD). Hence, the relevance of changes in heart rate to the development of TxCAD remains unclear. Intra-coronary ultrasound examinations (ICUS) were therefore analyzed in 130 heart transplant recipients (age 50 +/- 11 yr) studied at annual evaluations (3.7 +/- 3.0 yr after transplantation). Quantitative ultrasound measurements were obtained by calculating mean coronary artery intimal thickness (MIT) obtained by examination of the left anterior descending artery. The presence of TxCAD was defined as MIT > 0.3 mm. Resting heart rates (HR) were recorded with the @entity0 in the supine position during routine echocardiography. Based on HR recordings, two groups were defined: group 1, HR below; or group 2, HR above the median. TxCAD was detected in 40% of the ICUS studies overall. The prevalence of TxCAD was higher in group 1 (49%) compared with group 2 (33%), p < 0.05. There was no significant difference in donor ischemic time or donor gender, recipient age, gender, body weight, @entity5 status, @entity3 , total @entity1 , use of lipid lowering drugs or @entity6 . Donor age and use of beta-blockers were higher in group 1 compared with group 2 (29 +/- 10 vs. 25 +/- 9 yr, and 15% vs. 5%, for donor age and beta-blocker use, respectively). By multivariate regression analysis only donor age and years after transplantation were independently correlated with TxCAD. After excluding @entity0 taking beta-blockers and diltiazem, the prevalence of CAD was still higher in group 1 (50%) vs. group 2 (34%). In conclusion, transplant @entity2 is more prevalent in @entity0 with lower, rather than higher, heart rates. The reason for this is unclear, but may reflect impaired blood flow to the sinoatrial node.

title: Importance of XXXX in predicting transplant @entity2 .

answer: @entity4


abstract: OBJECTIVE: Routine endoscopic examination during primary surgery decreased the rate of residual @entity4 to 18% in our early experience. Based on this, we stopped performing routine second-look surgery in @entity0 who were endoscopically free of @entity4 at the end of primary surgery. We sought to investigate if second-look procedures after endoscopic-assisted surgery could safely be performed only in @entity0 at a high risk of @entity2 (extensive @entity1 , spontaneously @entity3 or fragmented @entity4 , @entity2 intentionally left). STUDY DESIGN: Case series with chart review. SETTING: Tertiary pediatric otolaryngology practice. SUBJECTS AND METHODS: @entity0 aged 1 to 16 years who were treated for @entity4 over 15-year period by a single surgeon. Extent of disease and endoscopic findings were compared with rates of @entity2 . Time to diagnosis of @entity2 and prognostic factors were analyzed. RESULTS: Forty-two @entity0 underwent endoscopically assisted middle ear surgery for @entity4 . Of 42 @entity0 , 7 (17%) had additional disease found by endoscopy that was missed by microscopy alone. Twelve @entity0 at high risk had second looks; 5 (42%) had @entity2 . Of 30 @entity0 , 2 (7%) presented with macroscopically evident residual @entity4 after no planned second look on office follow-up and subsequently underwent reoperation and were cured. CONCLUSIONS: Selective second-look surgery in high-risk @entity0 did not adversely affect outcome as compared with the low-risk group. @entity4 was identified endoscopically in 7 of 42 (17%) @entity0 thought to be microscopically free of disease at initial surgery. The endoscope may aid in visualization of difficult middle ear recesses when used to complement microscopy. Further investigation with multicenter data is needed.

title: Long-term Results of Endoscopically Assisted Pediatric XXXX Surgery.

answer: @entity4


abstract: @entity5 ( @entity5 ) develops at the site of the tick bite in 77-90% of @entity4 ( @entity4 ) @entity0 and is therefore a common manifestation of @entity1 . Clinical treatment failures have been reported in early @entity4 cases for almost every suitable antimicrobial agent. The exact risk of resistance to antibiotic treatment in @entity0 with @entity5 , however, is not known and there are few published cases of culture-proven treatment failure. Moreover, currently available diagnostic techniques cannot reliably discriminate between possible reinfection, true endogenous relapse and @entity2 with other tick-borne pathogens. These drawbacks together with the phenomenon of resistance to therapy in individual @entity0 undoubtedly contribute to the inconsistencies surrounding the optimal treatment regimens for @entity4 and are often misinterpreted and misused to support prolonged antibiotic treatment regimens. The question for the underlying mechanisms of possible antimicrobial resistance in @entity3 sensu lato remains unresolved but a better understanding of such genetic or phenotypic mechanisms would be helpful for the treatment of @entity4 and other @entity1 . Investigations on this issue, at best, should start with borrelial isolates cultured from @entity0 before the start of antibiotic therapy and again after the conclusion of treatment. This task, however, remains challenging insofar, as culture is rarely successful under routine laboratory conditions after antimicrobial therapy. Here, we review recent clinical and experimental data on treatment resistance in @entity5 @entity0 suggesting that, although rare, borrelial persistence does occur at the site of the infectious lesion after antibiotic treatment. Borrelial persistence, however, is unlikely to result from acquired resistance against antimicrobial agents that were used for initial specific chemotherapy.

title: Risk of culture-confirmed borrelial persistence in @entity0 treated for XXXX and possible mechanisms of resistance.

answer: @entity5


abstract: UNASSIGNED: @entity1 has been previously suggested as an adverse prognostic marker in @entity0 with @entity4 . To evaluate the relationship between @entity1 and clinical outcome, disease-free survival (DFS) and @entity2 ( @entity2 ), in @entity0 with @entity4 ( @entity4 ), including @entity3 ( @entity3 ), we performed a pooled analysis of four CALGB (Alliance) clinical trials. Our study included 446 @entity0 with @entity3 from CALGB 9710, and 1,648 @entity0 between 18 and 60 years of age with non- @entity3 @entity4 from CALGB 9621, 10503, and 19808. @entity1 was defined as BMI >= 30 kg/m(2) . Multivariate Cox proportional-hazard regression models were fitted for DFS and @entity2 . @entity1 was seen in 50% and 38% of @entity3 and non- @entity3 @entity4 @entity0 , respectively. In @entity3 @entity0 , @entity1 was associated with worse DFS (HR 1.53, 95% CI 1.03-2.27; P = 0.04) and @entity2 (HR 1.72, 95% CI 1.15-2.58; P = 0.01) after adjusting for age, sex, performance status, race, ethnicity, treatment arm and baseline white blood cell count. @entity1 was not significantly associated with DFS or @entity2 in the non- @entity3 @entity4 @entity0 . In conclusion, our study indicates that @entity1 has significant prognostic value for DFS and @entity2 in @entity3 @entity0 , but not for non- @entity3 @entity4 @entity0 . Am. J. Hematol. 91:199-204, 2016.    2015 Wiley Periodicals, Inc.

title: Relationship between @entity1 and clinical outcome in adults with XXXX : A pooled analysis from four CALGB (alliance) clinical trials.

answer: @entity4


abstract: BACKGROUND: High-density lipoprotein (HDL) protects against arterial atherothrombosis, but it is unknown whether it protects against recurrent @entity2 . METHODS AND RESULTS: We studied 772 @entity0 after a first @entity2 (average follow-up 48 months) and recorded the end point of symptomatic recurrent @entity2 , which developed in 100 of the 772 @entity0 . The relationship between plasma lipoprotein parameters and recurrence was evaluated. Plasma apolipoproteins AI and B were measured by immunoassays for all subjects. Compared with those without recurrence, @entity0 with recurrence had lower mean (+/-SD) levels of apolipoprotein AI (1.12+/-0.22 versus 1.23+/-0.27 mg/mL, P<0.001) but similar apolipoprotein B levels. The relative risk of recurrence was 0.87 (95% CI, 0.80 to 0.94) for each increase of 0.1 mg/mL in plasma apolipoprotein AI. Compared with @entity0 with apolipoprotein AI levels in the lowest tertile (<1.07 mg/mL), the relative risk of recurrence was 0.46 (95% CI, 0.27 to 0.77) for the highest-tertile @entity0 (apolipoprotein AI >1.30 mg/mL) and 0.78 (95% CI, 0.50 to 1.22) for midtertile @entity0 (apolipoprotein AI of 1.07 to 1.30 mg/mL). Using nuclear magnetic resonance, we determined the levels of 10 major lipoprotein subclasses and HDL @entity1 for 71 @entity0 with recurrence and 142 matched @entity0 without recurrence. We found a strong trend for association between recurrence and low levels of HDL particles and HDL @entity1 . CONCLUSIONS: @entity0 with high levels of apolipoprotein AI and HDL have a decreased risk of recurrent @entity2 .

title: High-density lipoprotein and the risk of recurrent XXXX .

answer: @entity2


abstract: It is important to develop methods to prevent or reverse the @entity3 caused by chemotherapy or radiation therapy for @entity1 in @entity0 . Radiation and some chemotherapeutic agents kill spermatogonial stem cells, but we have shown that these cells survive in @entity2 , although they are unable to differentiate. There is evidence that this phenomenon also occurs in @entity0 . The block to spermatogonial differentiation in @entity2 is caused by some unknown change, either in the spermatogonia or the somatic elements of the testis, such that @entity4 inhibits spermatogonial differentiation. In the @entity2 , the spermatogenesis and fertility lost following treatment with radiation or some chemotherapeutic agents can be restored by suppressing @entity4 with @entity6 ( @entity6 ) agonists or antagonists, either before or after the cytotoxic insult. The applicability of this procedure to @entity0 is still unknown. Some anticancer regimens may kill all the stem cells, in which case the only option would be spermatogonial transplantation. However, in some cases stem cells survive and there is one report of stimulation of recovery of spermatogenesis with hormonal treatment. Clinical trials should focus on treating @entity0 with hormones during or soon after anticancer treatment. The hormone regimen should involve suppression of @entity4 production with minimum @entity5 supplementation used to improve the diminished libido.

title: Suppression of XXXX stimulates recovery of spermatogenesis after @entity1 treatment.

answer: @entity4


abstract: We present a first case of concurrent @entity1 consisting of @entity3 and @entity4 arising at the same spinal level in a @entity0 without @entity5 . A 49-year-old @entity0 without clinical evidence of @entity5 presented with a 5-month history of right neck @entity2 . MRI demonstrated an @entity1 involving the right-sided C2 nerve root with a small intradural component. T1- and T2-weighted and contrast-enhanced MRI could not differentiate the @entity1 as different from the @entity1 . Total @entity1 was performed. No contiguity of the @entity1 with the @entity1 was seen. The @entity1 attached strongly to the dura mater around the C2 nerve root exits. Intraoperative pathological diagnosis confirmed the @entity1 as @entity3 and the @entity1 as @entity4 . We therefore thoroughly coagulated the dura mater adjacent to the @entity1 and resected the dura mater around the nerve root exits together with the @entity1 . Pathological examination revealed that the resection edge of the extradural component consisted of a spinal nerve with thickened epineurium and was free of neoplastic cells. No @entity3 component was evident in the @entity1 . No obvious transition thus existed between the extra- and @entity1 . Distinguishing these @entity1 prior to surgery is critical for determining an optimal surgical plan, as @entity3 and @entity4 require different surgical procedures. We therefore recommend a careful review of preoperative imaging with the possibility of concurrent @entity1 in mind.

title: Concurrent spinal nerve root XXXX and @entity4 mimicking single-component schwannoma.

answer: @entity3


abstract: @entity0 cells mate by an inducible pathway that involves agglutination, mating projection formation, cell fusion, and nuclear fusion. To obtain insight into the mating differentiation of @entity0 , we carried out a large-scale transposon tagging screen to identify genes whose expression is regulated by mating pheromone. 91,200 transformants containing random lacZ insertions were screened for @entity2 ( @entity2 ) expression in the presence and absence of alpha factor, and 189 strains containing @entity1 -regulated lacZ insertions were identified. Transposon insertion alleles corresponding to 20 genes that are novel or had not previously been known to be pheromone regulated were examined for effects on the mating process. Mutations in four novel genes, FIG1, FIG2, @entity4 / FIG3, and FIG4 were found to cause mating defects. Three of the proteins encoded by these genes, Fig1p, Fig2p, and Fig4p, are dispensible for cell polarization in uniform concentrations of mating pheromone, but are required for normal cell polarization in mating mixtures, conditions that involve cell-cell communication. Fig1p and Fig2p are also important for cell fusion and conjugation bridge shape, respectively. The fourth protein, @entity4 /Fig3p, is required for nuclear fusion. Fig1p and Fig2p are likely to act at the cell surface as Fig1:: @entity2 and Fig2:: @entity2 fusion proteins localize to the periphery of mating cells. Fig4p is a member of a family of eukaryotic proteins that contain a domain homologous to the @entity0 @entity3 . Our results indicate that a variety of novel genes are expressed specifically during mating differentiation to mediate proper cell morphogenesis, cell fusion, and other steps of the mating process.

title: Pheromone-regulated genes required for XXXX mating differentiation.

answer: @entity0


abstract: AIM: The Amplatzer duct occluder(R) is a new system for interventional occlusion of persistently @entity2 . The purpose of our study was to determine, whether adequate evaluation of this occluder system can be obtained by echocardiography. METHOD: From 11/1999 until 12/2000, 18 @entity0 were included in the study. All underwent interventional occlusion of a @entity2 with the Amplatzer duct occluder(R). Echocardiography was performed on admission, on day one and three and six months following the intervention. RESULTS: The mean age of our @entity0 was 4.8 years (9 months - 18.7 years, median 3.2 years), the mean weight was 18.4 kg (6.5 - 66 kg, median 14 kg). All echocardiographic findings prior to intervention were confirmed during cardiac catheterization. Following intervention we were able to visualize the occluder system and its relation to surrounding structures in all @entity0 . In none of our @entity0 we found an obstruction of the @entity1 . In 1/18 @entity0 there was a minor protrusion of the distal occluder into the descending aorta. Doppler-sonography however revealed no obstruction. Complete occlusion of the ductus arteriosus was confirmed by color Doppler echocardiography in all @entity0 within 5 days, in 17/18 @entity0 no residual shunt was detectable within 24 hours. CONCLUSION: According to our experience the results of interventional occlusion of @entity2 in @entity0 and adolescents can be well determined by echocardiography.

title: [Echocardiographic findings before and after interventional occlusion of persistently XXXX with the amplatzer duct occluder].

answer: @entity2


abstract: We present an update of our experience with the ketogenic diet (KD) in @entity0 with @entity2 ( @entity2 ) to evaluate the efficacy and tolerability and our short experience with vagus nerve stimulation (VNS) in the treatment of this syndrome. Between @entity3 , 1990 and May 31, 2007, 59 @entity0 who met diagnostic criteria for @entity2 were studied in our department. Twenty-four of them were placed on the KD and were followed up for a minimum of 2 years. Three @entity0 were treated with VNS. Sixteen (66.6%) of 24 @entity0 remained on the diet. Two @entity0 (12.5%) became @entity1 free, 10 @entity0 (62.5%) had a 75-99% decrease in @entity1 , and the remaining 4 @entity0 (25%) had a 50-74% decrease in @entity1 . Six @entity0 have been off the diet for >2 years; one of them is @entity1 free, two have @entity1 , and three, who abandoned the diet after 3 years of adhering to it, relapsed. As to the efficacy of VNS, two @entity0 had a 50-74% decrease in @entity1 and in the other @entity1 frequency remained unchanged. The device was well tolerated in all @entity0 without significant complications. Considering the severity and refractarity of @entity1 in @entity0 with @entity2 , the fact that 12 of 16 @entity0 who remained on the diet had a significant reduction in number of @entity1 shows that the KD is at present an interesting therapeutic option. VNS may be a good alternative treatment for @entity2 .

title: Nonpharmacologic treatments of XXXX : focus on the ketogenic diet.

answer: @entity2


abstract: The aim of this study was to reinvestigate many of the claims in the literature about @entity1 in @entity0 with Meni  re's disease. We carried this out on a well-defined group of @entity0 under well-controlled circumstances. Thus, we were able to find support for some claims and none for many others. As part of a diagnostic protocol, pure-tone and speech audiometry was performed on 111 @entity0 with Meni  re's disease according to the 'Definition Meni  re Groningen'. This was a prospective clinical cohort study. Affected ears of @entity0 suffering from Meni  re's disease show reduced hearing, both in pure-tone and in speech audiometry. A classification method was devised to determine audiogram shape in an objective manner. The results of this method indicate that affected ears more frequently show 'low' or 'low + high' @entity1 (P = 0.006). The shape of the @entity1 does not depend on the duration of the affection of the disease. In combination with the fact that the average @entity1 does not correlate with the duration of the disease, this leads to the conclusion that, if a classification of the @entity1 in Meni  re's disease is possible, such a classification cannot be connected to the duration. This conclusion is further supported by the fact that no relationship is found between the duration of the disease and the classification of the @entity1 over the 3 months before hospital admission, as given by the @entity0 in a questionnaire. A relationship between the (objective) audiometric data and the (subjective) classification of the @entity1 by the @entity0 seems to be present, but is not very strong. Correlations between pure-tone and speech audiometry are present as in non-Meni  re ears (r = 0.899, P < 0.001), and no indications are found of reduced speech discrimination relative to the expectation based on pure-tone loss. The audiogram shape does not appear to play any additional role in speech discrimination (in addition to the influence of the average pure-tone loss).

title: Pure-tone and speech audiometry in XXXX with Meni  re's disease.

answer: @entity0


abstract: PURPOSE: To prospectively assess the long-term @entity2 of brachytherapy in female survivors with localized genital tract @entity1 . @entity0 AND METHODS: The data concerning 42 @entity0 treated at Gustave Roussy between 1971 and 2004, were both retrospectively and prospectively analyzed. Strictly confidential constructed surveys based on the LENT SOMA/SF-36v2 questionnaires were mailed and 51% were completed. Complications were recorded throughout the follow-up period and graded according to CTCAE, version 4.0. RESULTS: The median age at diagnosis was 1.7years (range, 0.6-16.6) and most @entity0 (69%) had @entity3 . Treatments included brachytherapy delivered in all @entity0 , chemotherapy (88%), surgery (31%), and external beam radiotherapy (5%). At a median follow-up of 15.5years, 41/42 @entity0 were alive. A total of 160 late effects were identified in 32/42 (76%) @entity0 : 72% G1-2, and 28% G3-4 (the mean number of all grade late effects per @entity0 : 4 [median: 2.5; range, 0-16] and the mean number of G3-4 late effects per @entity0 : 1[median: 0; range, 0-8]). The most common all grade late @entity2 were gynecological (75/160; 47%) and G3-4 were urinary (24/45; 53%). Sixteen @entity0 (38%) required surgical treatment of late complications. The 15-year actuarial incidence rate of G3-4 late effects was 51%. The total number of all grade and G3-4 late effects was significantly increased in @entity0 treated before 1990 (p=0.005 and p=0.008), when the cumulative dose was higher (p=0.03 and p=0.02), when the maximal dose was delivered to the ovaries (p=0.002 and p=0.04), and when the brachytherapy volume was larger (p=0.03 and p=0.02). Quality of life was good or very good in 91% of @entity0 who completed the surveys. CONCLUSION: Long-term effects decreased with advances in treatment. Stringently controlled brachytherapy parameters should allow us to pursue improvements in order to prevent or minimize long-term sequelae.

title: Late XXXX of brachytherapy after female genital tract @entity1 treated during childhood: Prospective evaluation with a long-term follow-up.

answer: @entity2


abstract: OBJECTIVE: To investigate the current epidemiological characteristics of @entity1 and overweight in the middle-aged and elderly populations of china and to disclose their relation with such @entity3 as @entity2 . METHODS: A questionnaire survey and physical examination were conducted among the 35-85-years-old @entity0 from 14 densely populated residential areas representative in economic development and medical conditions in 14 provinces/municipality in China (i.e., Henna, Hebei, Shandong, Shanxi, Guangdong, Jiangxi, Tianjin, Inner Mongolia, Shaanxi, Hunan, Hubei, Yunnan, Sichuan, and Zhejiang) where a large-scale epidemiological survey of @entity4 were being conducted, one residential area for a province, selected by cluster sampling to investigate the health-related personal conditions and examine the blood pressure (BP), body height, weight, body mass index (BMI), etc. so as to understand the prevalence of overweight and @entity1 based on the diagnostic criteria of Chinese adults recommended by the Working Group on Obesity in China. RESULTS: 29056 @entity0 , 13549 males with the average body height of 168 cm +/- 7 cm, average weight of 68 kg +/- 11 kg, and average body mass index (BMI) of 24 kg/m(2) +/- 3 kg/m(2), and 15507 females with the average body height of 156 cm +/- 6 cm, average weight of 60 kg +/- 10 kg, and average BMI of 24 kg/m(2) +/- 4 kg/m(2), were surveyed. The BMI of @entity0 was significantly higher than that of @entity0 (P = 0.005). The total prevalence of overweight in the 14 provinces/municipality was 38.93%, and the standardized prevalence of overweight was 37.17%, the total prevalence of @entity1 was 13.94%, and the standardized prevalence was 12.63%. The prevalence of @entity1 of @entity0 was 12.29%, significantly lower then that of @entity0 (15.39%, P < 0.001). The prevalence of overweight of @entity0 was 412.18%, significantly higher then that of @entity0 (36.97%, P < 0.001). The prevalence rates of @entity1 and overweight increased with age in the age group 35-64; and decreased with age in the age group 65 and over. In the @entity0 , the prevalence of overweight was the highest in the age group 45-54 (44.57%), and the prevalence of @entity1 was the highest in the age 55-64 (13.60%). In the @entity0 , the prevalence of overweight was the highest in the age group 55-64 (40.10%), and the prevalence of @entity1 was the highest in the age group 65-74 (19.97%). The prevalence of @entity2 increased obviously with the BMI in these populations. CONCLUSION: Overweight and @entity1 are prevalent in China. Control of body weight is of great importance to the prevention and treatment of such @entity3 as @entity2 .

title: [Epidemiology of XXXX and overweight and relation thereof to the prevalence of @entity2 in 14 provinces/municipality in China].

answer: @entity1


abstract: Genetic predisposition controlled by susceptibility quantitative trait loci (QTLs) contributes to a large proportion of common @entity2 . Studies of genetics of @entity2 susceptibility, however, did not address systematically the relationship between susceptibility to @entity2 in different organs. We present five sets of data on genetic architecture of @entity1 susceptibility in @entity3 , @entity0 and @entity4 . They collectively show that the majority of genes for @entity1 susceptibility are linked pair-wise and are likely identical or related. Four CcS/Dem recombinant congenic strains, each differing from strain BALB/cHeA by a different small random subset of   12.5% of genes received from strain STS/A, suggestively show either extreme susceptibility or extreme resistance for both @entity5 , which is unlikely if the two @entity2 were controlled by independent susceptibility genes. Indeed, susceptibility to @entity1 (Sluc) loci underlying the extreme susceptibility or resistance of such CcS/Dem strains, mapped in 226 (CcS-10 x CcS-19)F2 @entity3 , co-localize with susceptibility to @entity5 (Scc) loci. Analysis of additional Sluc loci that were mapped in OcB/Dem strains and Scc loci in CcS/Dem strains, respectively, shows their widespread pair-wise co-localization (P = 0.0036). Finally, the majority of published @entity0 and @entity4 @entity5 susceptibility genes map to chromosomal regions homologous to @entity3 Sluc loci. 12/12 @entity3 Scc loci, 9/11 @entity0 and 5/7 @entity4 @entity5 susceptibility loci are close to a Sluc locus or its homologous site, forming 21 clusters of lung and @entity5 susceptibility genes from one, two or three species. Our data shows that @entity2 susceptibility QTLs can have much broader biological effects than presently appreciated. It also demonstrates the power of @entity3 genetics to predict @entity0 susceptibility genes. Comparison of molecular mechanisms of susceptibility genes that are organ-specific and those with trans-organ effects can provide a new dimension in understanding individual @entity2 susceptibility.

title: Most lung and @entity5 susceptibility genes are pair-wise linked in XXXX , @entity0 and @entity4 .

answer: @entity3


abstract: Mitotic spindles of a cultured endothelial cell line from @entity2 tadpole heart ( @entity4 ) contain distinct subsets of differentially stabilized microtubules (MTs) enriched in tyrosinated (Tyr) and in nontyrosinated ( @entity0 ) tubulin. Generally, the distribution of the more labile Tyr-MTs and of the @entity0 -MTs indicative for the more stable MT-subclass was remarkably different. During all mitotic stages the Tyr-staining of spindle fibers predominates, whereas the @entity0 -species was mainly restricted to the peripheral regions of half spindles where the MTs have to sustain a bending stress. Moreover, @entity0 -tubulin is enriched in prophase centrosomal areas, and, from metaphase on, exclusively also in the centrioles. @entity0 -positivity does not remain constant, instead, the intensity weakens from metaphase to telophase reflecting the decreasing MT nucleating capacity of the centrosomes. During the spindle cycle, the interzonal spindle at the anaphase-telophase transition exceeds all other stages in @entity0 -stainability and retains the high amount of detyrosinated MTs during telophase. External application of millimolar @entity3 has different effects upon spindle components organization: First, additional assembly of Tyr-MTs together with a @entity0 -negative reaction of the centrioles was registered and, secondly, a drastic disarrangement of the Tyr-staining spindle fiber component became evident. At the onset of anaphase, an extreme spindle lengthening presumably due to the separation of the Tyr- and @entity0 -MTs occurred. Obviously, the @entity0 -spindle fibers were less affected and remained largely in their original spindle position. Redistribution of anti-dynein staining following @entity3 incubation suggests a causal relationship between inhibition of dynein motor proteins and disarrangement of different microtubular spindle components. These results suggest that the changes in the spindle framework are at least partly due to malregulation of centrosomal phosphorylation events, respectively to inactivation of special cross-bridging proteins interacting between distinct MT-subsets by a phosphate mimicking effect of @entity3 and finally, by a @entity3 -induced @entity1 .

title: @entity3 affects both the tyrosination/detyrosination state of spindle microtubules and the organization of XXXX spindles.

answer: @entity4


abstract: Renomedullary @entity6 are benign lesions which are generally discovered in specimens nephrectomized for other @entity1 or by autopsy. We examined the histologic features of eight @entity1 from four @entity0 and investigated the appearance of @entity3 ( @entity3 )-positive cells in these @entity1 using immunohistochemistry. We considered that five @entity1 are cellular type and the remaining three as fibrous. Characteristic hyalinization was observed in two of the three @entity1 . All the @entity1 except for one fibrous type contained entrapped tubular cells. @entity5 -positive cells (dendritic cells) and @entity3 -positive cells were observed in all the @entity1 , with a more frequent occurrence in the cellular type than the fibrous type. @entity5 -negative spindle cells were considered as fibroblasts or activated fibroblasts (myofibroblasts). The number of @entity5 -positive cells was higher than that of @entity3 -positive cells. Additionally, the entrapped tubular cells showed the transition to spindle cells and some of them expressed for @entity3 . With double immunohistochemical staining, there were some cells showing positive reactions for both @entity5 and @entity3 . Furthermore, an ultrastructural examination confirmed the presence of @entity3 -positive filaments in the dendritic cells and myofibroblasts. The expression of @entity4 was observed not only in the @entity1 cells and the collecting ducts surrounding the @entity1 but also in the entrapped tubular cells. In addition, the intensity of @entity4 was stronger in/around the @entity1 than in the areas distant from the @entity1 . The positive cells were more numerous in the cellular type than in the fibrous type. In conclusion, @entity3 -positive cells appear in renomedullary @entity6 and some of the cells may originate in dendritic interstitial cells, fibroblasts including myofibroblasts, and entrapped tubular cells. Furthermore, @entity4 may contribute to the formation of @entity2 in the @entity1 .

title: Participation of @entity3 -positive cells in renomedullary XXXX .

answer: @entity6


abstract: The effect of @entity2 and the @entity4 -angiotensin system on metabolic coronary regulation in @entity3 was studied in 22 anesthetized open-chest @entity1 . Left circumflex coronary blood flow was measured with an electromagnetic flowmeter. @entity1 were ventilated with room air (n = 8) or 100% @entity0 (n = 7). A third group of @entity1 was ventilated with room air and bilaterally nephrectomized 5 h prior to starting the experimental protocol (n = 7). After control data had been obtained, @entity1 were bled from the femoral arteries into a pressurized reservoir which maintained blood pressure at 45 +/- 1 mmHg. The angiotensin II receptor blocker, @entity5 , was then infused i.v. (0.1, 1.0, 10.0 micrograms/kg per min). Coronary blood flow was reduced by @entity3 , and no significant difference existed in coronary flow during @entity3 among the three groups. Coronary sinus @entity0 saturation was diminished in control animals during @entity3 from 26% +/- 1% to 17% +/- 1% (P less than 0.05) but normal in 100% @entity0 ventilated animals (30% +/- 3%) and in nephrectomized @entity1 (34% +/- 4%). Coronary @entity0 extraction was reduced by @entity5 in intact but not in nephrectomized @entity1 . In six additional experiments, in which blood pressure was not artificially held constant during @entity5 infusion, @entity5 still significantly improved coronary sinus @entity0 saturation and thus reduced coronary @entity0 extraction. The data suggest that both @entity2 and the @entity4 -angiotensin system participate in the restriction of metabolic coronary regulation in @entity3 .

title: Deterioration of metabolic coronary regulation in @entity3 . Role of XXXX and the @entity4 -angiotensin system.

answer: @entity2


abstract: In @entity1 , the ratio of @entity5 : @entity3 production rate is decreased favouring the vasoconstrictive @entity3 . One of the rate-limiting steps in @entity4 synthesis is cyclooxygenase (COX) activity. Therefore, we investigated the expression of @entity6 and @entity2 in @entity0 placenta and placental bed. Tissue specimens from the 29th to 40th week of pregnancy were obtained from Caesarean sections after uncomplicated and pre-eclamptic pregnancies before the onset of labour. @entity6 and @entity2 were localized immunohistochemically with the identification of positive cells by double immunofluorescence staining. The protein and mRNA levels were analysed by immunoblotting and quantitative reverse transcriptase-polymerase chain reaction. Expression of both @entity6 and @entity2 could be observed in placenta and placental bed. @entity6 -like immunoreactivity was observed in most cell types with strongest staining in macrophages. Only macrophages, endothelium, vascular leiomyocytes and fibroblasts stained positively for @entity2 . In placenta, @entity7 expression was unchanged after @entity1 . In placental bed, protein and mRNA levels of @entity6 were increased in the pre-eclamptic group (P < 0.05), whereas @entity2 expression did not differ significantly from normal pregnancies. An increased expression of @entity6 could be involved in the pathophysiology of pre-eclamptic changes within the placental bed. A therapy with drugs inhibiting @entity6 might be beneficial in this condition.

title: Cyclooxygenase-1 and -2 in XXXX placenta and placental bed after normal and pre-eclamptic pregnancies.

answer: @entity0


abstract: BACKGROUND: The new method described here is highly efficient in transferring microinjected @entity0 eggs (MEs) through the bursa membrane of a surrogate mother @entity0 to the ampulla of the oviduct without damaging the blood vessels on the bursa membrane. RESULTS: This method causes no loss of blood, and it produces newborn pups/founders from approximately 70% of the transferred MEs, because only a small hole is made on the blood vessel-free area of the bursa membrane and ampulla of the surrogate mother @entity0 . The infundibulum remains intact. The small hole on the bursa membrane/ampulla may already heal up before the delivery of the new pups. The method described here consists of a simple operation with a home-assembled @entity1 head holding a self-closing fine forceps on one end, while the @entity1 head assembly body is hooked up with the light housing clamp of a dissecting light microscope. The @entity1 head assembly body can be alternatively hooked/tied up to an appropriate size of clamp (purchased from Home Depot) screwed to any light stand with folding segments. CONCLUSION: This system is able to steadily hold the self-closing fine forceps without shaking and to let the operator use their two hands to steadily hold and quickly insert the pipet carrying the MEs into the ampulla without any delay. Generally MEs stay alive for approximately 15  min at room temperature. The shorter the insertion time is, the more MEs that will survive. Thus, this method may produces more pups/founders.

title: Efficient method for transfer of microinjected eggs to @entity0 ampulla for generating XXXX .

answer: @entity0


abstract: AIMS: The effects on angiogenesis of a novel @entity3 ( @entity3 ) antagonist, @entity7 , derived from @entity0 stromal cell-derived factor-1beta (SDF-1beta), were examined in a model of hind limb ischaemia in @entity2 . METHODS AND RESULTS: The antagonistic activities of @entity7 against @entity3 were evaluated in vitro and in vivo and compared with @entity6 -buffered saline and @entity11 (a small bicyclam antagonist of @entity7 ). Angiogenesis, muscle regeneration and the expression of pro-angiogenic factors were evaluated in ischaemic gastrocnemius muscles. Distant toxic effects of @entity7 were evaluated by inflammatory and apoptotic markers. @entity7 induced @entity3 internalization and competitively inhibited the chemotaxis of SDF-1beta but did not mediate migration, @entity4 influx, or the phosphorylation of @entity5 and extracellular signal-regulated kinase in cultured @entity8 cells or H9C2 cells. @entity7 enhanced blood flow, angiogenesis, and muscle regeneration in ischaemic hind limbs, and the enhancement was significantly better than that of @entity11 . Markers of angiogenesis and progenitor cell migration, including phosphorylated @entity5 , @entity1 ( @entity1 ), @entity7 and @entity3 , were up-regulated by @entity7 and co-localized with @entity9 -positive cells. Neutralization of @entity1 with its specific antibody abolished @entity7 -induced blood reperfusion and angiogenesis. No apparent inflammatory and apoptotic effects were found in heart, liver, kidneys, and testes after @entity7 administration. CONCLUSION: Our findings indicate that the novel @entity3 antagonist, @entity7 , can efficiently enhance @entity10 , blood flow restoration, and muscle regeneration without apparent adverse effects, most likely through a @entity1 -dependent pathway.

title: A novel XXXX antagonist derived from @entity0 SDF-1beta enhances angiogenesis in ischaemic @entity2 .

answer: @entity3


abstract: BACKGROUND: Management of @entity5 has changed markedly since the introduction of @entity3 kinase inhibitors (TKIs). However @entity1 ( @entity1 ) remains a valid therapeutic modality especially in developing countries due to its relatively lower cost. We aim to compare between @entity6 and @entity1 as regard outcome in @entity5 in the pediatric age group. METHODS: Forty-eight @entity0 with newly diagnosed @entity5 in the chronic phase, aged 3 to 18 years were enrolled in this prospective study. @entity0 without a matched donor (Group I; N=30) were assigned to receive @entity6 at a dose of 340mg  m2  day, while @entity0 with a fully matched related donor (Group II; N=18), were offered @entity1 . Response (hematologic, cytogenetic and molecular), side effects and survival were analyzed. RESULTS: Complete hematologic response was obtained in 97% of the @entity0 in group I and 94% in group II. Major cytogenetic response (CyR) was obtained in 80% of @entity0 in group I and 100% in group II. Complete CyR was 57% in group I and 64% in group II. Major molecular response (MMR) was 36% in group I and 50% in group II with no significant difference between both groups. Six years @entity4 ( @entity4 ) was 87% in the 1st group and 61% in the 2nd group (p<0.01), while eventfree survival (EFS) was 66% in the 1st group and 50% in the 2nd group with a highly significant difference between both groups (p<0.01). Side effects were generally rare and mild in the @entity6 arm, while adverse events were more severe and common in the @entity1 group (55% had GVHD and 78% had @entity2 ). CONCLUSION: @entity6 has a superior @entity4 and EFS than @entity1 in @entity0 . It is generally safe and well tolerated. @entity6 should be the 1st line treatment of pediatric @entity0 with @entity5 in the chronic phase. KEY WORDS: @entity5 - @entity6 - @entity1 - Pediatrics.

title: Management of XXXX in the Pediatric Age Group: @entity6 or @entity1 .

answer: @entity5


abstract: PURPOSE: Thermobalancing therapy, provided by Therapeutic Device, which contains a natural thermoelement, and is applied topically in the projection ofthe prostate,was aimed to improve blood circulation in the affected organ. We evaluated the effectiveness of new Therapeutic Device for the treatment of @entity0 with @entity1 ( @entity1 ). MATERIALS AND METHODS: We performed a clinical non-randomized controlled trial before and after 6-month treatment. Therapeutic Device was administered to 124 @entity0 with @entity1 as mono-therapy. The dynamic of the @entity0 ' condition was assessed by the International Prostate Symptom Score (IPSS), ultrasound measurement of prostate volume (PV) and uroflowmetry. The control-group comprised 124 @entity0 who did not receive any treatment. The IPSS score, maximum flow rate (Qmax), and PV were compared between the groups. RESULTS: Baseline evaluation (pre-treatment) for both groups were comparable to each other with no clinically significant difference regarding age, IPSS score, Qmax and PV volume. Overall, thermobalancing therapy resulted in significant improvements from baseline to endpoint in IPSS (P = .001), IPSS storage and voiding subscores (both P = .001), and IPSS quality of life index (QoL) (P = .001) compared with control group. Moreover, comparison of parameters after 6 months treatment showed that thermobalancing therapy also improved the Qmax (P = .001), and PV (P = .001). CONCLUSION: Two years clinical trial demonstrated that thermobalancing therapy administered for 6 months provides a marked improvement in @entity0 presenting with symptomatic @entity1 not only on lower urinary tract symptoms (LUTS) but also in QoL and Qmax. Thus urologists should be aware about thermobalancing therapy as a non-invasive physiotherapeutic treatment option for treatment of @entity1 ._nbsp.

title: XXXX Treatment with New Physiotherapeutic Device.

answer: @entity1


abstract: BACKGROUND: This cross-sectional study was carried out in a population-based setting in Worcestershire to investigate the relationship between social deprivation and other potential prognostic factors. METHODS: A total of 762 female @entity1 diagnosed with primary @entity0 between 1 January 1998 and 31 December 1999 were selected. @entity0 included all new cases of primary @entity0 and @entity3 in situ. A total of 753 @entity1 were matched by their postcode of residence to enumeration district Townsend score and then divided into three groups based on Townsend quintiles (affluent n = 478; middle n = 157; deprived n = 118). Main outcome measures were relationships between social deprivation and @entity2 type, stage at presentation, @entity4 receptor status, @entity2 grade and treatment type. RESULTS: Compared with the most deprived @entity1 , affluent @entity1 were less likely to present with @entity2 (70.8 per cent versus 85.9 per cent, chi2 linear trend = 6.757, p = 0.009), @entity2 of higher grade (36.0 per cent versus 44.7 per cent, chi2 linear trend = 4.201, p = 0.040), and @entity4 receptor negative @entity2 (22.4 per cent versus 33.3 per cent, chi2 linear trend = 3.501, p = 0.061). There was no significant difference in stage or @entity2 size at presentation between deprivation groups. More deprived @entity1 with invasive @entity2 of less than 20 mm maximum diameter were significantly more likely to have mastectomies than affluent @entity1 (47.8 per cent versus 32.1 per cent, chi2 linear trend = 4.091, p = 0.043). CONCLUSIONS: This study suggests that level of social deprivation is associated with @entity2 type, grade and @entity4 receptor status. There was also a suggestion that increased level of deprivation was associated with increased risk of potentially unnecessary mastectomies.

title: Social deprivation and XXXX .

answer: @entity0


abstract: Nine @entity0 with @entity2 and @entity1 treated with IV @entity4 chemotherapy (30 mg/m2/30 min) entered this study. Plasma and peritoneal fluid levels were measured by an HPLC method with electrochemical detection. Plasma decay kinetics followed a triexponential function. A high variability of drug diffusion in @entity3 was noticed. Peak concentrations in @entity3 ranged from 1.6% to 20.5% of serum peak concentration. The concentration in peritoneal fluid reached a maximum level 6 h after the infusion ended. @entity4 was less slowly eliminated from @entity3 than from serum. The exposure of the inflammatory peritoneal fluid to the drug expressed by area under the concentration-time curve (AUC) was also subject to significant interindividual variation, ranging from 223 to 2332 micrograms/ml X min. However, the peritoneal AUC was correlated with serum AUC and with the systemic clearance of the drug. A significant relationship between gamma glutamyltranspeptidase and both systemic clearance and either the serum or the peritoneal AUC was found, suggesting that liver plays a role in drug disposition.

title: Pharmacokinetics of @entity4 ( @entity4 ) after IV administration in serum and XXXX of @entity0 with @entity2 .

answer: @entity1


abstract: The association between @entity1 and spontaneous @entity4 is now well established and thought to be responsible for @entity2 in up to 40% of cases. @entity4 that is due to @entity1 is refractory to the use of tocolytic agents. So the knowledge that @entity1 may be the cause is unhelpful once a @entity0 is admitted in spontaneous @entity4 , since by that time there may be irreversible changes in the uterine cervix, which renders futile those attempts to inhibit the process. It would be much more logical to use the association between @entity1 and spontaneous @entity4 to identify a group of @entity0 at risk and to intervene using antibiotic prophylaxis. It is important to record, that the earlier in gestation at which abnormal genital tract colonisation is detected, the greater is the risk of an adverse outcome. For example, @entity3 at 26-32 weeks gestation is associated with @entity2 with an odds ratio (OR) of 1.4 to 2, whereas @entity3 at 7-16 weeks gestation carries an OR of 5 to 7.5. Intervention studies have used different antibiotics in different dosage regimes by different routes of administration to @entity0 of differing risks at different gestational ages. Not surprisingly this has led to differing results. If intervention is to be successful, the antibiotics chosen should be active against @entity5 or @entity5 and should be used early in pregnancy in those @entity0 with the greatest degree of @entity3 . While there is logic in using intravaginal antibiotics to deliver a heavy antibiotic load to the vagina where heavy abnormal colonisation exists, there is also logic in considering systemic antibiotics to eradicate those organisms, which have already gained access to the decidua. It may be that the greatest chance of benefit would exist if both routes of administration were combined. Yet no study has evaluated the combination of both intravaginal and systemic antibiotics to eradicate @entity3 for the prevention of @entity2 .

title: Infection in the prediction and antibiotics in the prevention of spontaneous XXXX and @entity2 .

answer: @entity4


abstract: UNASSIGNED: @entity3 (P4) is capable of inducing acrosome reaction in many species. The objective of this study was to determine the activity of enzymes involved in metabolism that contribute to the redox state and supply energy for acrosome reaction in cryopreserved bull spermatozoa. To accomplish this aim, acrosome reaction was induced by P4 in capacitated and non-capacitated samples. @entity4 and @entity5 aminotransferases (ALT, AST) and @entity2 kinase (CK) activities were measured spectrophotometrically at 340nm after acrosome reaction with P4. @entity0 consumption was measured polarographically. ALT and AST activities increased by the addition of P4 capacitated and non-capacitated samples. P4 addition provoked an increase in CK activity in non-capacitated spermatozoa compared to heparin capacitated spermatozoa with or without P4 addition. P4 increased @entity0 consumption, the percentage of acrosome reacted spermatozoa as well as the absence of acrosome integrity in both capacitated and non-capacitated @entity1 spermatozoa, but @entity0 consumption in P4 samples was significantly lower than in heparin capacitated spermatozoa (P<0.05). Acrosome reaction induction by P4 required different @entity2 kinase activity with the same @entity0 consumption and transaminases level to maintain oxidative metabolism and redox state through reducing equivalents transfer between cytosolic and mitochondrial compartment. In conclusion, P4 induces a lower oxidative metabolism during acrosome reaction in @entity1 cryopreserved spermatozoa, compared to @entity6 induced capacitation process.

title: @entity3 causes metabolic changes involving aminotransferases and XXXX kinase in cryopreserved @entity1 spermatozoa.

answer: @entity2


abstract: Background. Clinical trials indicate that the benefit of adding concurrent chemotherapy to radiotherapy of locally advanced @entity2 ( @entity2 ) for fit elderly is similar to the benefit for younger @entity0 . However, since elderly @entity0 are under-represented in most trials, the results might be due to selection bias, thus reports from a cohort of consecutively treated @entity0 are warranted. The current single institution study reports on the influence of age on survival of locally advanced @entity2 @entity0 treated with radiotherapy combined with or without concurrent chemotherapy. Material and methods. Altogether, 478 @entity0 completed radical radiotherapy in doses of 60-66 Gy/30-33 fractions from 1995 to June 2012; 137 of the @entity0 had concurrent chemotherapy. The data was analyzed in age groups < 60, 60-69, and >=  70 years. Results. In the analyses of overall and @entity1 specific survival the hazard ratio was related to the use of concurrent chemotherapy was 0.49 (95% CI 0.29; 0.82), 0.68 (95% CI 0.48; 0.98) and 1.01 (95% CI 0.67; 1.51) for the age groups < 60, 60-69, and >=  70, respectively. Conclusion. Use of concurrent chemotherapy to radiotherapy of locally advanced @entity2 was associated with a survival benefit in @entity0 younger than 70 years which was not the case for @entity0 older than 70 years, indicating the need to be careful when selecting elderly @entity0 for concurrent chemo-radiation.

title: Age dependent prognosis in concurrent chemo-radiation of locally advanced XXXX .

answer: @entity2


abstract: BACKGROUND: @entity11 , a @entity2 caused by @entity9 usually thought to cause relatively minor morbidity, can cause serious and often fatal reactions in @entity0 carrying very high levels of circulating @entity9 microfilariae (mf) following administration of microfilaricidal drugs. An experimental model of this condition would greatly aid the definition of the optimal management of this important clinical presentation. METHODOLOGY/PRINCIPLE FINDINGS: Fifteen @entity10 ( @entity7 ) were infected with 600 infective larvae (L3) isolated from Chrysops vector flies. Animals were observed for any clinical changes; blood samples were collected every 1-2 months for 22 months, and analysed for parasitological, hematological and biochemical profiles using standard techniques. All animals became patent but remained clinically normal throughout the study. The parasitological pre-patent period was between 4-8 months, with a majority (60%) of animals becoming patent by 5 months post infection (MPI); all animals were patent by 8 MPI. Microfilarial loads increased steadily in all animals and reached a peak at 18 MPI. By 10 MPI >70% of animals had mf >8,000 mf/mL, and at 18 MPI >70% of animals had mf >30,000mf/mL with 50% of these animals with mf >50,000mf/mL. Absolute eosinophil, @entity5 , @entity1 and @entity8 levels were generally above normal values (NV). Positive associations were seen between microfilariaemia and @entity6 , Hb, @entity1 , and gamma-GT values, whilst significant negative associations were seen between microfilariaemia and @entity4 , @entity3 and mononuclear leukocyte levels. CONCLUSIONS: Infection of splenectomised @entity10 with L. loa can induce levels of circulating microfilariae, and corresponding haematological profiles, which parallel those seen in those @entity0 in danger of the severe post-microfilariacide clinical responses. Utilization of this experimental model could contribute to the improved management of the loiasis related adverse responses in @entity0 .

title: Parasitological, Hematological and Biochemical Characteristics of a Model of Hyper-microfilariaemic XXXX ( @entity9 ) in the @entity7 ( @entity7 ).

answer: @entity11


abstract: PURPOSE: The aim of the present study was to examine the risk of lost workdays due to sick leave and disability pension by treatment modality and relapse in a population-based cohort of @entity1 survivors versus matched comparators. METHODS: We identified 1971 @entity1 @entity0 aged  <=60  years (median 42) at diagnosis in Sweden 2003-2009 and 9254 population comparators. Information on sociodemographic and clinical characteristics, sick leave, and disability pension was retrieved from nationwide prospective registers. Differences in the annual mean number of lost workdays were calculated by linear regression, and hazard ratios (HRs) of disability pension were calculated by Cox regression analysis, with follow-up through September 2013. RESULTS: Cervical @entity1 @entity0 had more lost workdays annually than comparators up to 8  years following diagnosis. Relapse-free @entity0 had more lost workdays than comparators up to 4  years. Risk of disability pension during follow-up was increased among the relapse-free @entity0 treated with hysterectomy ( @entity2 [95  % confidence interval (CI) 1.1-2.8]), hysterectomy plus chemotherapy and/or radiotherapy (HR 2.5 [95  % CI 1.2-5.4]), or chemotherapy and/or radiotherapy alone (HR 3.0 [95  % CI 1.3-6.8]), compared with the population. @entity0 treated with fertility-sparing surgery did not have more lost workdays than the population beyond the first year and were not at increased risk of disability pension. CONCLUSION: We observed a long-standing increased risk of lost workdays among @entity1 @entity0 , overall, as well as among relapse-free @entity0 . IMPLICATIONS FOR CANCER SURVIVORS: Extensive but not limited treatment was associated with increased risk of lost workdays, possibly reflecting an association between treatment side effects and work ability.

title: Lost workdays in uterine XXXX survivors compared to the general population: impact of treatment and relapse.

answer: @entity1


abstract: The optimum therapy for @entity0 with relapsed or @entity11 ( @entity11 ) not qualifying for @entity8 -based and/or high-dose chemotherapy is not known. We conducted a prospective phase II study evaluating a regimen consisting of @entity1 (1 g/m2, days 1 and 8), @entity9 (30 mg/m2, days 1 and 8) and @entity4 (100 mg/day, days 1-8) (GVP) given every 21 days. Fifteen @entity0 with a median age of 68 years and a median of three previous therapies were enrolled. Diagnoses included B lymphoblastic (n=1), diffuse large B cell (n=10), anaplastic large T cell (n=2) and peripheral T-cell @entity11 (n=2). The median international prognostic index score was 3 (six @entity0 with a score of 4 or 5). Five @entity0 achieved a complete remission and three @entity0 a partial remission. The median overall survival was 13.8 months, and the median time to next treatment was 4.4 months. @entity2 of World Health Organisation grades 3/4 were @entity10 in 58%, @entity7 in 33% and @entity6 in 17% of all courses. Three @entity0 had grade 3 @entity5 . There was no treatment-related mortality. GVP shows substantial activity in poor prognosis relapsed or @entity3 and is generally well tolerated, but haematological @entity2 is dose limiting.

title: @entity1 , XXXX and @entity4 for refractory or relapsed @entity3 , results of a phase II single center study.

answer: @entity9


abstract: OBJECTIVE: To investigate the patterns of hepatic involvement and the outcome of @entity0 with hepatic metastases from @entity4 . METHODS: Of 1665 @entity0 with @entity4 , 20 @entity0 with hepatic metastases were detected clinically during the course of the disease. Clinical presentation and detailed patterns of hepatic involvement were retrospectively reviewed for these @entity0 . Comparative analysis between patterns of heaptic metastases and survival data was also undertaken. RESULTS: Hepatic @entity1 from @entity4 were nearly always accompanied by uncontrolled locoregional diseases and/or extrahepatic metastases, whereas only 1 @entity0 developed an isolated hepatic @entity1 . Ninety percent of the hepatic metastases were metachronously detected. The median time from the appearance of @entity3 to detection of hepatic metastases was 39 months, but late metastases after 5 years were not uncommon. @entity1 in 16 @entity0 consisted of @entity2 distributed in either one or both anatomical lobes, whereas only 4 @entity0 had a solitary lesion confined to a single lobe. @entity0 with hepatic metastases were unlikely to survive 2 years with a median survival of 10 months. CONCLUSION: Favorable patterns of hepatic metastases in @entity0 with @entity4 were not major determinants of favorable survival if components of @entity5 were concomitantly present.

title: Hepatic metastases from XXXX .

answer: @entity4


abstract: In October 2000, 71,187 @entity0 were treated for @entity2 using @entity1 and @entity3 ( @entity4 ) or @entity4 alone in Leogane, Haiti. We documented the frequency of adverse reactions, severity and cost of treatment. Adverse reactions were classified as minor, moderate, or severe. Overall, 24% (17,421) of the treated @entity0 reported one or more adverse reactions. There were 15,916 (91%) minor and 1502 (9%) moderate adverse reaction reports. @entity0 outnumbered @entity0 2:1 in reporting moderate problems. Three @entity0 , representing roughly one in 25,000 @entity0 treated, were hospitalized with severe adverse reactions judged to be treatment-associated by physician review. The cost per @entity0 treated for adverse reactions was more than twice the cost per @entity0 treated for @entity2 (dollar 1.60 versus dollar 0.71). Severe adverse reactions to @entity2 treatment using @entity4 with or without @entity1 are uncommon. Minor and moderate reactions are more commonly reported and their management represents a challenge to @entity2 elimination programs.

title: Frequency, severity, and costs of adverse reactions following mass treatment for @entity2 using @entity3 and XXXX in Leogane, Haiti, 2000.

answer: @entity1


abstract: UNASSIGNED: Background. @entity3 is characterized by blockage of electrical impulses from the atrioventricular node (AV node) to the ventricles. This blockage can be caused by ion channel impairment that is the result of genetic variation. This study aimed to investigate the possible causative variants in a Thai family with complete @entity1 by using whole exome sequencing. Methods. Genomic DNA was collected from a family consisting of five family members in three generations in which one of three @entity0 in generation III had complete @entity1 . Whole exome sequencing was performed on one complete @entity1 affected @entity0 and one unaffected sibling. Bioinformatics was used to identify annotated and filtered variants. Candidate variants were validated and the segregation analysis of other family members was performed. Results. This study identified compound heterozygous variants, @entity5 and @entity6 , in the @entity2 gene and @entity7 in the @entity4 gene. Conclusions. Compound heterozygous variants in the @entity2 gene were found in the complete @entity1 affected @entity0 but these two variants were found only in the this affected sibling and were not found in other unaffected family members. Hence, these variants in the @entity2 gene were the most possible disease-causing variants in this family.

title: Exome Sequencing Identifies Compound Heterozygous Mutations in XXXX Associated with @entity3 in the Thai Population.

answer: @entity2


abstract: BACKGROUND: @entity4 is increasingly recognized as a treatable @entity1 . We report the first long-term, naturalistic follow-up of @entity0 with @entity4 , which examined the @entity2 over 1 year in a cohort that had completed up to 3 months of open-label treatment with @entity3 , 20 mg/day to 60 mg/day. In that trial, 17 (71%) of 24 subjects who met McElroy and colleagues' diagnostic criteria for @entity4 were responders (Clinical Global Impressions-Improvement scale rating of much or very much improved and Yale-Brown Obsessive Compulsive Scale-Shopping Version score decrease of >/= 50%). METHOD: Follow-up interviews occurred 3, 6, 9, and 12 months after study end. Data gathered included comorbid conditions, estimated total debt, 2-week spending, whether the @entity0 was taking @entity3 , and illness versus remission status. Remission was defined as no longer meeting diagnostic criteria for @entity4 . Data were gathered between March 2000 and January 2002. RESULTS: Of responders at trial end, 81% (13/16), 71% (10/14), 71% (10/14), and 73% (11/15) were in remission at 3, 6, 9, and 12 months. Mean 2-week compulsive shopping expenditures decreased from 773 US dollars (median = 500 US dollars) at baseline to 351 US dollars (median = 0 US dollars) at month 12, and mean total debt decreased from 17,833 US dollars (median = 20,000 US dollars) to 16,752 US dollars (median = 14,000 US dollars). No clear association was seen between taking @entity3 and remission status (p =.55, p =.08, p =.58, and p =.60 at 3, 6, 9, and 12 months, respectively; Fisher exact test). The majority of trial nonresponders remained ill at each follow-up point. CONCLUSION: An acute response to @entity3 predicts a greater likelihood of continued remission over 1 year, although the mechanisms that maintain remission require further investigation.

title: A 1-year naturalistic follow-up of XXXX with @entity4 .

answer: @entity0


abstract: @entity2 ( @entity2 ) progresses through three distinct clinical stages: chronic phase, accelerated phase, and @entity5 . The progression to accelerated phase and @entity5 is driven by activation of oncogenes, inactivation of @entity1 suppressor genes, and/or amplification of the @entity3 fusion gene, which causes the chronic phase of the disease. The cell of origin of @entity5 is a subject of speculation. Here, I develop a simple mathematical model of @entity2 to investigate whether blasts arise from leukemic stem cells or more differentiated leukemic cells. I use data of @entity0 treated with @entity4 and previous agents to estimate the effects of therapy on the rate of progression. @entity4 reduces the progression rate 10-fold as compared with previous (ineffective) therapies. If blasts were produced by leukemic stem cells, there would be no difference in the rate of progression between @entity0 treated with @entity4 and previous therapies, because @entity4 seems to be incapable of depleting leukemic stem cells. @entity4 does, however, deplete leukemic progenitors. Therefore, @entity2 blasts are likely to arise from leukemic progenitors. Disclosure of potential conflicts of interest is found at the end of this article.

title: XXXX @entity5 arises from progenitors.

answer: @entity2


abstract: INTRODUCTION: Situs inversus totalis with @entity7 represents a relatively rare @entity3 . CASE DESCRIPTION: The current report describes the case of a 56  year old @entity0 with an atrio-ventricular and ventricular-arterial discordance of the @entity2 without surgical correction, incidentally detected during hepatocellular @entity1 evaluation. The systemic venous blood arrived via the right atrium and a mitral valve in the morphologically left but pulmonary arterial ventricle that gave rise to a pulmonary trunk. The pulmonary venous blood passed the left atrium and the tricuspid valve into a morphologically right but systemic ventricle that gave rise to the aorta. DISCUSSION AND EVALUATION: The switched anatomy was incidentally detected on echocardiography. The @entity0 was referred to cardiac magnetic resonance imaging (CMR) including flow measurements, volumetry and late enhancement. CMR results showed a mildly impaired function and the switched anatomy. During a follow-up period of 2  years the @entity0 was suffering from only mild @entity4 and @entity6 . CONCLUSIONS: @entity4 symptoms and @entity5 can appear with increasing age in @entity0 with congenitally corrected transposition. Early CMR allows accurate diagnosis and timely introduction of adequate therapy thereby avoiding disease progression.

title: Situs inversus totalis with XXXX : insights from cardiac MRI.

answer: @entity7


abstract: OBJECTIVE: A decline in @entity4 function is often seen in elderly @entity0 , and @entity5 is common. Symptoms of both @entity4 and @entity5 include dysphoria, @entity3 , and low libido. The authors compared total @entity1 levels in three groups of elderly @entity0 . METHOD: Total @entity1 levels were measured in subjects who met DSM-IV criteria for @entity2 (N=13) or @entity5 (N=32) and a comparison group (N=175) who had participated in an epidemiological study of male aging and had scored below the median on the Center for Epidemiologic Studies Depression Scale, a well-validated, self-report @entity2 symptom inventory. RESULTS: There were no differences among the three groups in measured demographic variables, including age and weight. Median @entity1 levels varied for those with @entity5 (295 ng/dl), @entity2 (425 ng/dl), and no @entity2 (423 ng/dl). A test for differences in central tendency showed a statistically significant difference among the three groups. Post hoc pairwise comparisons revealed statistically significant differences between those with @entity5 and those with @entity2 and no @entity2 . CONCLUSIONS: Total @entity1 levels were lower in elderly @entity0 with @entity5 than in @entity0 with @entity2 and @entity0 without @entity2 symptoms. @entity5 in elderly @entity0 may be related to @entity4 .

title: Low @entity1 levels in elderly XXXX with @entity5 .

answer: @entity0


abstract: PURPOSE: To evaluate the efficiency of perforated punctal plug in acquired @entity2 . MATERIALS AND METHODS: Forty-five eyes of 33 @entity0 who had @entity5 due to @entity2 were included in this study. After biomicroscopic examination and lacrimal @entity1 was managed with the perforated punctal plugs in all @entity0 . In the following period @entity5 , plug tolerance, lacrimal drainage were evaluated and graded. Lacrimal drainage was evaluated with @entity3 dye disappearing test. RESULTS: The age of the @entity0 ranged between 31 and 80 (mean 55.78      13.11). Preoperatively punctal dilatation and lacrimal system irrigations were performed on all @entity0 . Lacrimal system irrigation was positive in all @entity0 . Perforated punctal plugs were placed in the inferior puncti in all @entity0 . The plugs were explanted 6  months after operation. The follow-up period ranged between 6 and 24  months. Plug tolerance was good in 97.8% of the eyes in the 1st month visit. @entity5 decreased remarkably in 88.9% of the @entity0 1  month after plug implantation, except one whose plug dropped off spontaneously in 2  weeks. @entity3 disappearing times were found under 3  min in 97.8% of the eyes after plug explanations. CONCLUSION: Punctum stenosis is one of the several disorders that cause lacrimal @entity4 . Perforated punctal plugs are found convenient and effective in managing @entity2 .

title: Management of acquired XXXX with perforated punctal plugs.

answer: @entity2


abstract: Though they are knowledgeable, foundation year one (FY1) doctors can lack skills and confidence in acute situations due to inexperience. This was witnessed when a new FY1 on call attended an acute @entity1 ( @entity1 ), a common emergency with a 10% in hospital mortality rate. We aimed to improve FY1s' ability to manage these critical @entity0 through simulation based teaching, before and after the introduction of an algorithm summarising current guidelines. After assessing the FY1s' perceived level of confidence in managing UGIBs, they individually attended a simulation session which evaluated specific aspects of their assessment and management plans. Immediate debriefing and subsequent teaching sessions reinforced learning points, with an algorithm instituted as an aide m  moire to improve efficiency. A repeat simulation session assessed improvements in both subjective confidence and objective management targets. All FY1s expressed improved confidence in managing @entity0 with UGIBs. There were improvements across the board in their assessment and management, notably: verbalisation of concern for @entity2 increased to 100% (from 60%), two points of intravenous access requested in 100% of cases (from 53%), and a 76 second reduction in time to call for senior support. Collectively, these individual aspects led to improved @entity0 care. Effective management of acute @entity0 is best learnt through exposure, and simulation based teaching provides a safe but powerful modality to aid transition from textbook theory to ward situations. Algorithms can streamline care and hasten the stabilisation of @entity0 . This project reinforces generic competencies that FY1s can translate to their management of not only UGIBs, but many acute presentations, providing a convincing argument for broader simulation use in FY1 teaching.

title: Promoting the management of acute upper XXXX among junior doctors: a quality improvement project.

answer: @entity1


abstract: OBJECTIVE: Localized @entity3 is a common disease for which minimally invasive treatment methods are being explored. Perineal prostatectomy, as a historical open procedure, is modified to incorporate contemporary surgical ideas. There is relatively little in the literature regarding modern adaptations of perineal prostatectomy. This method of anatomic radical perineal prostatectomy has been developed to accomplish a minimally invasive method of achieving goals of disease control and preservation of genito-urinary functions. METHODS: Prospective outcome data is accumulated on 508 consecutive radical perineal prostatectomies by a single surgeon. Pathologic stage and PSA detectability are measures of @entity1 control. Pad use and ability to complete intercourse measure urinary and sexual function. General complications and other outcome measures are evaluated. RESULTS: Freedom from PSA detectability by pathologic stage is 96.3%, 79.4%, and 69.4% for organ confined, specimen confined and margin positive in the absence of seminal vesical invasion with an average 4 years follow up (3-114 months). Margins are positive in 18% of cases. The average @entity1 size is 9.4g and 36% of cases have extracapsular invasion. By the first, third, sixth months and one year, 38%, 65%, 88% and 96% are free of pad use and report being dry. While over 80% of nerve-spared @entity0 enjoy the return of spontaneous erectile function, the @entity0 with bilateral nerve preservation note earlier and more complete return of function. There are no cardiopulmonary complications or @entity2 . Transfusions occurred in 1%, none in the past 400 cases. Average total hospital charges are USD 4889.00 in 1999 and 2000. @entity4 , anastomotic strictures and fecal urgency/stress flatus occur 2%, 2% and 2-4%, respectively. CONCLUSIONS: This method of prostatectomy is able to achieve complete @entity1 resection while preserving urinary and sexual function as well as laparoscopic or retropubic prostatectomy. The simplicity and minimally invasive nature of this procedure contribute to a short recovery and low overall cost of therapy. The anatomic radical perineal prostatectomy is a cost-efficient, outcome effective minimally invasive method of treating @entity0 with @entity3 .

title: Radical perineal prostatectomy: cost efficient, outcome effective, minimally invasive XXXX management.

answer: @entity3


abstract: BACKGROUND: Computed tomography perfusion (CTP) is increasingly being used in the setting of @entity1 ( @entity1 ). The aim of the current study was to compare the prognostic utility of, and inter-observer variation between, baseline appearances on non-contrast CT (using Alberta @entity1 Program Early CT score(ASPECTS)) and on CTP for predicting final @entity2 volume. We also assessed impact of training on interpretation of these images. METHODS: Retrospectively, plain head computed tomography (CT) and CTP images at presentation and CT or diffusion imaging on follow up of @entity0 with @entity1 were analyzed. The lesion volume on different CTP parameters was then correlated with the final @entity2 volume. This analysis was done by a Neuroradiologist, a @entity1 Neurologist and a medical student. Kappa statistics and Intra-class correlation coefficients were used for agreement between readers. Pearson correlation coefficients were used. RESULTS: Thirty eight @entity0 with @entity1 met all inclusion criteria. There was very good agreement among all readers for the CTP parameters. There was only fair agreement for ASPECT score. Correlation coefficient (r-square) between CTP parameters and final @entity2 volume showed that cerebral blood volume was the best parameter to predict the final @entity2 volume followed by cerebral blood flow and time to peak. The best reader to predict the final @entity2 volume on the initial CT perfusion study was the neuroradiologist followed by medical student and @entity1 neurologist. CONCLUSIONS: Cerebral blood volume defect correlated the best with the final @entity2 volume. There was a very good inter-observer agreement for all the CTP maps in predicting the final @entity2 volume despite the wide variation in the experience of the readers.

title: CT Perfusion in XXXX Predicts Final Infarct Volume- Inter-observer Study.

answer: @entity1


abstract: In the crystal structure of a calmodulin (CaM)-bound @entity7 domain of @entity0 inducible @entity2 synthase ( @entity5 ), the CaM-binding region together with CaM forms a hinge, and pivots on an R536( @entity5 )/E47(CaM) pair (Xia et al. J Biol Chem 284:30708-30717, 2009). Notably, isoform-specific @entity0 inducible @entity5 S562 and C563 residues form @entity6 bonds with the R536 residue through their backbone oxygens. In this study, we investigated the roles of the S562 and C563 residues in the @entity5 @entity7 - @entity3 interdomain electron transfer (IET), the rates of which can be used to probe the interdomain @entity7 / @entity3 alignment. @entity0 inducible @entity5 @entity8 and @entity9 mutants of an oxygenase/ @entity7 (oxyFMN) construct were made by introducing charged residues at these sites as found in @entity0 neuronal @entity5 and endothelial @entity5 isoforms, respectively. The IET rate constant of the @entity8 mutant is notably decreased by one third, and its @entity4 fluorescence intensity per micromole per liter is diminished by approximately 24  %. These results suggest that a positive charge at position 562 destabilizes the @entity6 -bond-mediated @entity5 /CaM alignment, resulting in slower @entity7 - @entity3 IET in the mutant. On the other hand, the IET rate constant of the @entity9 mutant is similar to that of the wild-type, indicating that the mutational effect is site-specific. Moreover, the @entity0 inducible @entity5 oxyFMN @entity10 mutant was constructed to disrupt the bridging CaM/ @entity5 interaction, and its @entity7 - @entity3 IET rate was decreased by 96  %. These results demonstrated a new role of the isoform-specific @entity1 residue of the key CaM/ @entity7 ( @entity5 ) bridging site in regulating the @entity7 - @entity3 IET (possibly by tuning the alignment of the @entity7 and @entity3 domains).

title: Role of an isoform-specific XXXX residue in @entity7 - @entity3 electron transfer in inducible @entity2 synthase.

answer: @entity1


abstract: We aimed to summarize the etiology, clinical characteristics, diagnosis, and possible treatment options of @entity3 in @entity1 @entity0 of both sexes. Details of dysfunction in @entity1 @entity0 are less conclusive than in @entity0 due to the lack of standardized evaluation of sexual function in @entity0 . Male @entity3 is a common complication of @entity1 , including abnormalities of orgasmic/ejaculatory function and desire/libido in addition to penile erection. The prevalence of @entity4 ( @entity4 ) among @entity1 @entity0 varies from 35% to 75%. @entity1 -induced @entity4 has a multifactorial etiology including metabolic, neurologic, vascular, hormonal, and psychological components. @entity4 should be regarded as the first sign of @entity2 because it can be present before development of symptomatic @entity6 , as larger coronary vessels better tolerate the same amount of plaque compared to smaller penile arteries. The diagnosis of @entity4 is based on validated questionnaires and determination of functional and @entity5 . First-, second- and third-line therapy may be applied. @entity8 ( @entity8 ) inhibitor treatment from the first-line options leads to smooth muscle relaxation in the corpus cavernosum and enhancement in blood flow, resulting in erection during sexual stimulus. The use of @entity8 inhibitors in the presence of oral @entity7 is strictly contraindicated in @entity1 @entity0 , as in nondiabetic subjects. All @entity8 inhibitors have been evaluated for @entity4 in @entity1 @entity0 with convincing efficacy data. Second-line therapy includes intracavernosal, trans- or intraurethral administration of vasoactive drugs or application of a vacuum device. Third-line therapies are the implantation of penile prosthesis and penile revascularization.

title: @entity3 in XXXX .

answer: @entity1


abstract: OBJECTIVES: This study sought to examine the treatment of @entity0 with @entity4 in a prospective sample of @entity0 referred to a tertiary center for @entity1 . BACKGROUND: Despite the wide diffusion of guidelines for @entity1 management in @entity0 , their application in general practice is far from optimal. METHODS: This prospective study analyzed previous @entity1 treatment by general practitioners in 151 consecutive @entity0 (F/M: 0.82; mean age 10.4 +/- 3.2 years) referred for @entity4 to the Lille University Hospital Neuropediatric department between October 1, 2003, and November 30, 2005. The physician completed a questionnaire according to the parents' responses to questions about previous advice about life-style adjustments (diet, exercise, and sleep hygiene) and abortive and prophylactic treatment. Questions about abortive treatment covered ergot derivatives, @entity3 , and 3 aspects of @entity5 use-appropriate dose (ie, more than 7.5 mg/kg), recommendation to administer the drug early in attacks, and warnings about @entity2 . Under the topic of prophylactic treatment, we asked about information from general practitioners about preventive therapy and advice to keep a @entity1 diary. RESULTS: Fewer than 15% of @entity0 had received advice about life-style adjustments. Only 30.3% had received @entity5 at a correct dose (more than 7.5 mg/kg); only 26.5% were told to use it early during the @entity1 ; and only 9.1% were warned about @entity2 . Ergot derivatives were prescribed to 4.6% of @entity0 and @entity3 to 9.1%. Families of 17.9% reported that the general practitioners gave them information about prophylactic treatment. Only 8.0% were advised to keep a @entity1 diary. CONCLUSION: This study shows the need to increase the role and the involvement of family doctors in the management of primary @entity1 in @entity0 in general, and of pediatric @entity4 in particular.

title: French general practitioners' management of @entity0 's XXXX .

answer: @entity4


abstract: BACKGROUND: Discovering an effective approach to provide cardioprotection against @entity3 has long been sought. We studied the cardioprotective effect of resistance training against @entity1 -reperfusion-induced injury. METHODS: Twenty male @entity0 were divided into trained and sedentary groups (n = 10 in each). The @entity0 were exercised in squat-training apparatus (12 repetitions/set, four sets/day and five days/week for 12 weeks). After the last training session, transient regional @entity1 of left anterior descending coronary artery (40 min) was followed by 80 min of reperfusion. Coronary flow, left ventricular developed pressure, diastolic pressure and @entity4 size were measured. RESULTS: After 35 min of @entity1 , coronary flow and developed pressure were higher in trained than untrained groups (10.37    0.96 vs 7.54    0.89 mL/min   g, p < 0.01 for coronary flow and 67.74    3.31 vs 52.39    4.28 mm Hg, p < 0.01 for developed pressure) and this difference persisted until 50 min of reperfusion (10.59    0.88 vs 7.71    0.73 mL/ /min   g, p < 0.01 for coronary flow and 58.12    4.07 vs 39.56    3.79 mm Hg, p < 0.01 for developed pressure). Diastolic pressure was significantly lower from 35 min of @entity1 (11.51    5.37 vs 24.53    5.44 mm Hg, p < 0.05) through 35 min of reperfusion in trained rather than sedentary @entity0 (30.62    3.19 vs 43    7.11 mm Hg, p < 0.01). Resistance exercise training reduced the @entity4 size statistically in trained @entity0 as compared with sedentary animals (39.32    4.09 vs 29.36    4.17 percentage of zone at risk, p < 0.05). CONCLUSIONS: These results show that chronic resistance exercise provides cardioprotection against @entity2 .

title: Role of 12-week resistance training in preserving the heart against XXXX -reperfusion-induced injury.

answer: @entity1


abstract: OBJECTIVE: To investigate the feasibility and clinical characteristics of small partial laryngectomy without tracheotomy for @entity9 stage @entity4 . METHOD: Forty-five @entity0 with @entity7 in @entity9 stage received small partial laryngectomy without tracheotomy. RESULT: All @entity0 were primarily healed and were hospitalized for an average of 11.5 days post-operatively. In all @entity0 , the function of respiration and the reflection of cough were normal, and @entity8 did not happen. The only postoperative complication was @entity10 noted in 29 @entity0 . Among them, @entity10 extincted after 4-6 days in 26 patiens, only 3 patiens suffered from @entity5 because the @entity10 extincted after 2 weeks. Mild @entity10 did not affect the function of respiration and deglutition, healing of wound, and psychology of @entity0 . All @entity0 had been followed-up for 1-13 years. Only 2 @entity0 died of @entity2 recurrence or @entity1 . The function of respiration and deglutition were normal in the living @entity0 , and no implanting @entity1 on surface of @entity6 were found. CONCLUSION: The theoretical foundation of small partial laryngectomy without tracheotomy for @entity9 stage @entity4 has been well established. This surgical technique is feasible, safe and effective. It can significantly improve clinical outcome of @entity9 stage @entity4 with minimal invasiveness. Furthermore, it can obviously abate the surgical, physiological and psychological @entity3 on @entity0 .

title: [Small partial laryngectomy without tracheotomy for @entity9 stage XXXX ].

answer: @entity4


abstract: OBJECTIVES: The goal of this study was to assess the efficacy of minimally invasive interventional radiologic (IR) techniques in the management of uretero-enteric fistulae in comparison to established surgical modalities. MATERIALS AND METHODS: Twenty-five @entity0 (16 @entity0 , 9 @entity0 ) with a mean age of 47 (range: 19-77 years) with uretero-enteric fistulae were treated with percutaneous nephrostomy, double "J" stent, radiologic uretero-neocystostomy, and radiologic uretero-pyelocalicostomy. All @entity0 had a single @entity3 each. Uretero-enteric @entity3 were due to direct or iatrogenic @entity2 in 14 @entity0 (uretero-ileal @entity3 , n=6; uretero-colonic @entity3 , n=4; uretero-duodenal @entity3 , n=2; uretero-pancreatic @entity3 , n=1; uretero-fallopian tube, n=1), complications of @entity4 in 4 @entity0 (uretero-sigmoid @entity3 , n=4), @entity1 in 4 @entity0 (uretero-ileal @entity3 , n=2; uretero-sigmoid @entity3 , n=2), and @entity5 of renal transplants in 3 @entity0 (uretero-sigmoid @entity3 , n=3). RESULTS: Drainage by percutaneous nephrostomy and double "J" stent resulted in closure of 8 uretero-enteric fistulae over 7-16 weeks. Four uretero-enteric fistulae obliterated after re-routing urine flow using 3 radiologic uretero-neocystostomies and one IR pyelocalicostomy. In other @entity0 , flow through the fistulae was substantially decreased by five double "J" stents and 3 percutaneous nephrostomies. The duration of inpatient hospitalization was significantly less for @entity0 managed successfully by IR procedures than those treated by surgical modalities, 5.07 versus 10.5 days mean (P<0.05). CONCLUSIONS: IR procedures provided definitive treatment in 48% of uretero-enteric fistulae at significantly reduced inpatient hospitalization and cost. As palliative treatment, it improved the quality of life.

title: Minimally invasive radiologic techniques in the treatment of uretero-enteric XXXX .

answer: @entity3


abstract: BACKGROUND: Postoperative mortality rates have been published in relation to operative procedure or preexisting @entity4 . We analyzed our @entity0 for the effect of the @entity3 stage on perioperative mortality. @entity0 AND METHODS: Retrospective study of all thoracotomies for resections ( n=1281) in primary @entity1 from January 1987 to December 1997. Uni- and multivariate analysis was performed for operative procedure, mortality (30 and 90 days), @entity2 stage, sex, age, @entity2 localization, and completeness of resection. Radical resection was achieved in 91.9% of the @entity0 . RESULTS: Overall postoperative deaths occurred in 4% and 7.3% of @entity0 after 30 and 90 days respectively. Depending on the operative procedure the mortality after segmental resection ( n=116) was 0.9% and 1.7%, lobectomy ( n=621) 3.0% and 5.7%, sleeve lobectomy ( n=152) 5.3% and 7.9%, and pneumonectomy ( n=314) 6.7% and 12.5%, respectively. Within 30 and 90 days postoperatively deaths occurred, respectively, in 0.8% and 1.0% of stage I @entity0 ( n=493), 5.4% and 5.4% of stage II ( n=147), 4.9% and 8.8% of stage IIIa ( n=388), 7.2% and 16.6% of stage IIIb ( n=148), 8.9% and 20.5% and of stage IV ( n=114). Multivariate analysis showed @entity3 stage to be the factor most closely related to within the first 90 days. CONCLUSIONS: @entity2 stage but not type of resection is the strongest predictor of postoperative mortality in these subpopulations.

title: XXXX stage and early mortality for surgical resections in @entity1 .

answer: @entity2


abstract: BACKGROUND: We report an extremely rare case of concomitant huge exophytic @entity4 and @entity8 ( @entity8 ). CASE PRESENTATION: The @entity0 was a 67-year-old @entity0 experiencing abdominal distension since September 2006. A physical examination revealed a 25 x 30 cm hard mass that was palpable in the middle and lower left abdomen minimal intrinsic mobility and massive @entity5 . Since the admitted @entity0 was diagnosed with DIC, surgery could not be performed. The @entity0 received a platelet transfusion and the DIC was treated. Due to this treatment, the platelet count recovered to 7.0 x 10(4); @entity1 resection was performed at 16 days after admission. Laparotomy revealed a huge extraluminal @entity1 arising from the greater curvature of the stomach that measured 25 x 30 cm and had not ruptured into the peritoneal cavity or infiltrated other organs. Partial gastric resection was performed. The resected mass measured 25 x 25 x 20 cm. In cross section, the @entity1 appeared hard and homogenous with a small polycystic area. Histopathology of the resected specimen showed large spindle cell GIST with >5/50 @entity7 ( @entity7 ) mitotic activity. The postoperative course was uneventful, and the @entity6 improved rapidly. CONCLUSION: Since the characteristic of @entity1 in this case was hypervascularity with @entity3 and @entity2 , @entity6 was thought to be caused by the trapping of platelets within a large vasculized @entity1 mass.

title: A rare case of concomitant huge exophytic gastrointestinal stromal tumor of the stomach and XXXX .

answer: @entity8


abstract: AIM: The aim of this study was to evaluate the technical and oncological feasibility of laparoscopic total mesorectal excision (TME) with coloanal @entity3 for mid and low @entity1 . METHODS: During a 2-year period, 50 @entity0 underwent laparoscopic TME with coloanal @entity3 for @entity2 located at a median of 4.5 (range 2-11) cm from the anal verge. Pre-operative radiotherapy was used in 46 @entity0 . Intersphincteric dissection was combined with the laparoscopic procedure to achieve sphincter preservation. RESULTS: Conversion to a laparotomy was necessary in six @entity0 . Postoperative mortality and morbidity were 2% and 28%, respectively. Morbidity was lower in @entity0 operated on during the second part of the study, who had extraction of the rectal specimen through a small laparotomy incision, than in those operated on during the first part of the study when removal of the specimen was by transanal extraction. Oncological quality of excision was safe in 44 @entity0 with intact or almost intact rectal fascia in 88% and R0 resection in 90%. At a median follow-up of 18 months, there was no local or port-site recurrence. CONCLUSION: This study confirms our preliminary results of oncological feasibility of laparoscopic TME with sphincter preservation for mid and low @entity1 , and showed that morbidity can be decreased by using a standardized surgical procedure.

title: Technical and oncological feasibility of laparoscopic total mesorectal excision with pouch coloanal @entity3 for XXXX .

answer: @entity1


abstract: UNASSIGNED: Controlled transgene expression via a promoter is particularly triggered in response to pathogen infiltration. This is significant for eliciting disease-resistant features in crops through genetic engineering. The germins and germin-like proteins (GLPs) are known to be associated with plant and developmental stages. The 1107-bp @entity1 root GLP2 (OsRGLP2) gene promoter fused to a b-glucuronidase (GUS) reporter gene was transformed into @entity0 plants through an Agrobacterium-mediated transformation. The OsRGLP2 promoter was activated in response to @entity3 (Mart.) Sacc. and Alternaria solani Sorauer. Quantitative real-time PCR results revealed 4-5-fold increase in promoter activity every 24  h following infection. There was a 15-fold increase in OsRGLP2 promoter activity after 72  h of @entity3 (Mart.) Sacc. treatment and a 12-fold increase observed with A. solani Sorauer. Our results confirmed that the OsRGLP2 promoter activity was enhanced under fungal stress. Furthermore, a hyperaccumulation of @entity2 in transgenic plants is a clear signal for the involvement of OsRGLP2 promoter region in the activation of specific genes in the @entity0 genome involved in @entity2 -mediated defense response. The OsRGLP2 promoter evidently harbors copies of GT-I and Dof transcription factors (AAAG) that act in response to elicitors generated in the wake of pathogen infection.

title: Germin-like protein 2 gene promoter from XXXX is responsive to fungal pathogens in transgenic @entity0 plants.

answer: @entity1


abstract: UNASSIGNED: Infection by Shiga toxin (Stx)-producing enterohemorrhagic @entity4 (EHEC) results in severe @entity2 , @entity5 , and, occasionally, @entity10 ( @entity10 ). @entity10 is associated with an increase in pro-inflammatory cytokines and chemokines, many of which are produced by macrophages in the kidneys, indicating that localized host innate immunity likely plays a role in renal pathogenesis. EHEC serotypes may express one or two classes of serologically defined but structurally and functionally-related Shiga toxins called @entity11 and @entity12 . Of these, @entity12 appears to be linked to higher rates of @entity10 than @entity11 . To investigate a possible reason for this, we exposed @entity0 macrophage-like @entity9 cells to @entity11 or @entity12 and then used the Luminex multiplex system to assess cytokine/chemokine concentrations in culture supernatant solutions. This analysis revealed that, relative to @entity11 , @entity12 significantly caused increased expression of @entity7 , @entity8 , @entity6 and @entity3 in macrophage-like @entity9 cells. This was determined to not be due to a difference in @entity1 since both @entity11 and @entity12 displayed similar cytotoxic activities on macrophage-like @entity9 cells. These observations indicate that, in vitro, @entity12 can provoke a greater pro-inflammatory response than @entity11 in macrophages and provides a possible partial explanation for higher rates of @entity10 in @entity0 infected with EHEC strains expressing @entity12 . To begin to determine a mechanism for Shiga toxin-mediated cytokine production, we exposed macrophage-like @entity9 cells to @entity11 or @entity12 subunits. Luminex analysis of cytokines in cell culture supernatant solutions demonstrated that neither subunit alone induced a cytokine response in @entity9 cells.

title: The Effects of Shiga Toxin 1, 2 and Their Subunits on Cytokine and Chemokine Expression by XXXX Macrophage-Like @entity9 Cells.

answer: @entity0


abstract: @entity9 is a novel orally active nonpeptidal antihypertensive agent that specifically blocks the @entity8 . This paper compares the short- and long-term safety and tolerability of @entity9 with those of placebo. Approximately 3800 @entity0 with mild-to-severe essential @entity4 were enrolled in 16 double-masked and 4 open clinical trials worldwide. Of these, approximately 2900 were treated with @entity9 either alone or in combination with other antihypertensive drugs. These trials included @entity0 with @entity1 (n = 133). An additional 5 trials enrolled @entity4 @entity0 with compromised renal function (n = 115) or @entity5 (n = 220). @entity9 dosages primarily ranged from 10 to 150 mg once daily, with most @entity0 receiving 50 to 100 mg per day. @entity4 trials generally lasted 12 weeks. The most frequently reported adverse events were @entity3 , @entity7 , dizziness, and @entity6 /fatigue, but only dizziness occurred more frequently (> or = 1%) in the @entity9 -treated groups. Cough occurred in 3.1% of @entity0 treated with @entity9 and 2.6% of @entity0 treated with placebo. The overall incidence of clinical and laboratory adverse events in the @entity9 - and placebo-treated groups was similar among @entity0 with @entity4 and either @entity1 , @entity2 , or @entity5 . The data suggest that @entity9 can be safely administered in @entity4 @entity0 with concomitant illnesses. It can be considered for first-line therapy and is suitable as an alternative therapy in @entity0 already experiencing side effects with other agents.

title: Clinical safety and tolerability of XXXX .

answer: @entity9


abstract: UNASSIGNED: Intraocular pressure (IOP) is a critical risk factor in @entity2 , and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced @entity0 in @entity2 is at the optic nerve head (ONH). However, the mechanisms that cause IOP-induced damage at the ONH are far from understood. A possible sequence of events could originate with IOP-induced stress in the ONH connective tissue elements ( @entity4 , scleral canal and lamina cribrosa) that leads to an increase in biomechanical strain. In consequence, molecular signaling cascades might be activated that result in extracellular matrix turnover of the @entity4 , changing its biomechanical properties. @entity5 might induce reactive changes in ONH astrocytes and cause astrogliosis. The biological changes that are associated with ONH astrocyte reactivity could lead to withdrawal of trophic or metabolic support for optic nerve axons and cause their degeneration. Alternatively, the expression of @entity3 molecules might be induced. Unfortunately, direct experimental in vivo evidence for these or other scenarios is currently lacking. The pathogenic processes that cause @entity1 at the ONH in @entity2 need to be identified before any regenerative therapy is likely to succeed. Several topics and emerging techniques should be pursued to enhance our understanding of the mechanisms that are behind @entity1 . Among them are: Advanced imaging techniques, the development of in vivo markers to identify @entity0 , the generation of molecular approaches for in vivo detection of mechanosensitivity and for molecular manipulation of the ONH, a more complete characterization of retinal ganglion cells, the use of organ cultures, 3D-bioprinting, and the engineering of microdevices that can measure pressure. Questions that need to be answered relate to the specific roles of astrogliosis, neuroinflammation, blood flow and intracranial pressure in @entity1 at the ONH.

title: Biological aspects of @entity0 in XXXX : A brief review.

answer: @entity2


abstract: BACKGROUND _ AIMS: The incidence of @entity3 is lower in countries in the Mediterranean basin. Virgin olive oil, a key component of the Mediterranean Diet (MDiet), with recognised beneficial effects on metabolism and cardiovascular health, may decrease the risk of @entity3 . The aim to this study was to explore the effect of chronic consumption of total olive oil and its varieties on the risk of @entity1 -related @entity2 in a middle-aged and elderly Mediterranean population. METHODS: We included all @entity0 (n  =  870) recruited in the Reus (Spain) centre of the PREvenci  n con DIeta MEDiterr  nea (PREDIMED) trial. Individuals, aged 55-80  years at high cardiovascular risk, were randomized to a MedDiet supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or a low-fat diet. The present analysis was an observational cohort study nested in the trial. A validated food frequency questionnaire was used to assess dietary habits and olive oil consumption. Information on total @entity3 was obtained from a systematic review of medical records. The association between yearly repeated measurements of olive oil consumption and @entity2 risk was assessed by multivariate Cox proportional hazards. RESULTS: We documented 114 incident cases of @entity1 -related @entity2 during a median follow-up of 8.9 years. Treatment allocation had no effect on @entity2 risk. @entity0 in the highest tertile of extra-virgin olive oil consumption had a 51% lower risk of @entity2 (HR:0.49; 95% CI:0.29-0.81. P for trend  =  0.004) compared to those in the lowest tertile after adjusting for potential confounders. Total and @entity4 oil consumption was not associated with @entity2 risk. CONCLUSIONS: Higher consumption of extra-virgin olive oil is associated with a lower risk of @entity1 -related @entity2 in middle-aged and elderly Mediterranean population at high cardiovascular risk.

title: Extra virgin olive oil consumption reduces the risk of XXXX in the PREDIMED trial.

answer: @entity3