abstract: The @entity8 is an infrequently diagnosed impressive psychosomatosis. The @entity0 (exclusively female) suffering from this disorder are described as "angry young @entity0 ". They are considered hysterical, masochistic, @entity3 , hostile and timid. Physically the syndrome is characterized by atypical, @entity2 , apparently spontaneous skin bleeding in young @entity0 and these @entity0 look like they have been beaten, injured or are seriously ill. Besides @entity5 , @entity4 , uterine @entity4 , @entity1 or unconsciousness as well as numerous symptoms of conversion in the narrower sense of the word have been observed, e.g. loss speech, gait deviation, or feelings of discomfort. To this day the pathophysiological peculiarity that enables the @entity0 to transform subconscious @entity6 events into the specific temporary alteration in the permeability of the capillary walls being a constitutional variant characteristic of females suffering from @entity8 and activated by @entity6 stimuli. In the case history presented, the problem is the @entity6 working out of narcissistic injuries in the context of a borderline structure. These injuries turn into physical symptoms analogous to the process of conversion. Since, in this case, there is no question of a defense against @entity7 to speak of a "narcissistic conversion". Quite peculiar is the universally described resemblance of the @entity0 to one another. The syndrome, together with the character and psychodynamic features, is repeated in almost a stereotypical manner. An explanation for this phenomenon cannot be expected even from the discovery of a pathophysiological detail in the blood vessels. Rather, we are confronted with one of those extremely rare syndromes where, in a limited field, physical and @entity6 events are completely blended. The physical events such as affects and defense mechanisms for which they can be substituted at random and without mutual interference. It is as though these disorders had retained a phylogenetically lost unity and primeval capability of interchanging @entity6 and somatic structures and, so to speak, preserved them in the manner of a museum. These syndromes make us surmise that in processes of somatization a recourse to ancient, long-faded psychosomatic relationships may play a certain role.

title: [Borderline structure and @entity2 XXXX : a case of @entity8 ].

answer: @entity4


abstract: A significant number of @entity0 receive either an unlicensed or an off-label drug during their stay in hospital. Studies throughout Europe have shown that at least one-third of @entity0 in hospital and up to 90% of neonates in a neonatal intensive care unit receive such drug prescriptions. The medicines that are most frequently used off-label include analgesics, antibiotics and bronchodilators. The purpose of licensing a drug is to ensure safety, efficacy and quality. If a drug is used in a different manner, one would expect a greater risk of @entity1 . Only three studies have commented on the risk of @entity1 in relation to unlicensed or off-label drug use. Only one of these three studies prospectively tried to evaluate the risk associated with off-label and unlicensed drug prescription. This study suggested that the percentage of unlicensed and off-label drug use was significantly associated with the risk of an @entity1 . Two studies looking at @entity1 suggest that there is a greater risk of a severe @entity1 occurring in association with the off-label or unlicensed use of drugs. One study found that five out of eight severe @entity1 were associated with the off-label use of a medicine. The other study found that 14 of 19 drug prescriptions associated with 17 severe @entity1 were either unlicensed or off-label. The risk of prescribing off-label and unlicensed drugs in @entity0 is not clear from the limited data available.

title: Unlicensed and off-label drug use in XXXX : implications for safety.

answer: @entity0


abstract: Having identified a disease-associated @entity4 mutation in a @entity0 with @entity3 ( @entity3 ), the issue is to address the question of whether to offer genetic testing to at-risk family members. Two members of a South African (SA) family, one of whom suffers from @entity3 , as well as 54 unrelated SA @entity3 @entity0 from the same population group were investigated using single-stranded conformational polymorphism analysis followed by DNA sequencing. A rare homozygous mutation at the intron-exon boundary of exon 4 in the @entity4 gene was identified in the proband. One of his siblings was found to be heterozygous for the same mutation. The mutation was not detected in the 54 unrelated SA @entity3 @entity0 examined, 11 of whom were sporadic cases. A low incidence of @entity3 amongst heterozygous carriers of this mutation has been reported; however, in the past it has been unclear whether the mutation has an effect in single copy or dual copy. To the best of our knowledge, this is the first time that this mutation has been reported as homozygous in an affected individual, thereby resolving the issue and confirming that it is a recessive disease-associated mutation. This is also the first @entity2 -causing @entity4 mutation that has been identified in Southern Africa. Analysis of the extended pedigree indicated obligate heterozygous carriers of the mutation, without obvious signs of @entity1 in early adulthood. The extent to which potential heterozygous carriers should be pursued and clinically examined is discussed and the question is addressed as to whether to inform the family of these molecular findings.

title: A rare homozygous XXXX splice-site mutation: the issue of when and whether to offer presymptomatic testing.

answer: @entity4


abstract: Object The aim of this study was to investigate the incidence of CSF disturbances before and after intracranial surgery for pediatric @entity3 in a large, contemporary, single-institution consecutive series. Methods All pediatric @entity0 (those < 18 years old), from a well-defined population of 3.0 million inhabitants, who underwent craniotomies for @entity1 at Oslo University Hospital in Rikshospitalet between 2000 and 2010 were included. The @entity0 were identified from the authors' prospectively collected database. A thorough review of all medical charts was performed to validate all the database data. Results Included in the study were 381 consecutive craniotomies, performed on 302 @entity0 (50.1% male, 49.9% female). The mean age of the @entity0 in the study was 8.63 years (range 0-17.98 years). The follow-up rate was 100%. Primary craniotomies were performed in 282 cases (74%), while 99 cases (26%) were secondary craniotomies. @entity1 were located supratentorially in 249 cases (65.3%), in the posterior fossa in 105 (27.6%), and in the brainstem/diencephalon in 27 (7.1%). The surgical approach was supratentorial in 260 cases (68.2%) and infratentorial in 121 (31.8%). Preoperative @entity2 was found in 124 cases (32.5%), and 71 (86.6%) of 82 achieved complete cure with @entity1 resection only. New-onset postoperative @entity2 was observed in 9 (3.5%) of 257 cases. The rate of postoperative CSF leaks was 6.3%. Conclusions Preoperative @entity2 was found in 32.5% of pediatric @entity0 with @entity3 treated using craniotomies. Tumor resection alone cured preoperative @entity2 in 86.6% of cases and the incidence of new-onset @entity2 after craniotomy was only 3.5%.

title: Cerebrospinal fluid disturbances after 381 consecutive craniotomies for XXXX in pediatric @entity0 .

answer: @entity1


abstract: UNASSIGNED: PURPOSE OF THE STUDY The wear of articular surfaces is considered one of the most important factors limiting the life of @entity1 ( @entity1 ). It is assumed that the particles released from the surface of a softer material induce a complex inflammatory response, which will eventually result in osteolysis and @entity3 . Implant wear is related to a friction coefficient which depends on combination of the materials used, roughness of the articulating surfaces, internal clearance, and dimensions of the prosthesis. MATERIAL AND METHODS The selected parameters of the bearing couples tested were studied using an experimental device based on the principle of a pendulum. Bovine serum was used as a lubricant and the load corresponded to a @entity0 body mass of 75 kg. The friction coefficient was derived from a curve of slowdown of pendulum oscillations. Roughness was measured with a device working on the principle of interferometry. Clearance was assessed by measuring diameters of the acetabular and femoral heads with a 3D optical scanner. The specimens tested included unused metal-on-highly cross-linked @entity2 , ceramicon-highly cross-linked @entity2 and ceramic-on-ceramic bearing couples with the diameters of 28 mm and 36 mm. For each measured parameter, an arithmetic mean was calculated from 10 measurements. RESULTS 1) The roughness of @entity2 surfaces was higher by about one order of magnitude than the roughness of metal and ceramic components. The Protasul metal head had the least rough surface (0.003  m). 2) The ceramic-on-ceramic couples had the lowest clearance. Bearing couples with @entity2 acetabular liners had markedly higher clearances ranging from 150  m to 545  m. A clearance increased with large femoral heads (up to 4-fold in one of the couple tested). 3) The friction coefficient was related to the combination of materials; it was lowest in ceramic-on-ceramic surfaces (0.11 to 0.12) and then in ceramic-on- @entity2 implants (0.13 to 0.14). The friction coefficient is supposed to increase with a decreasing femoral head diameter. However, in the bearing couples with @entity2 liners manufactured by one company, paradoxically, the friction coefficient slightly increased with an increase in femoral head size from 28 mm to 36 mm. 4) The lowest friction moment (< 3.5 Nm) was found for ceramic-on-ceramic implants 28 mm in diameter; the highest values were recorded in metal-on- @entity2 bearing couples 36 mm in diameter (> 7 Nm). DISCUSSION Although our study confirmed that the bearing couples produced by different manufacturers varied to some extent in the parameters studied, in our opinion, this variability was not significant because it was not within an order of magnitude in any of the tests. CONCLUSIONS The study showed that both the friction coefficient and the friction moment are affected more by the combination of materials than by the diameter of a femoral head. The best results were achieved in ceramic-on-ceramic implants. Key words: @entity1 , bearing surfaces, wear, friction coefficient, friction moment, clearance.

title: [Determination of a Friction Coefficient for XXXX Bearing Couples].

answer: @entity1


abstract: A 66-year-old @entity0 developed paresthesia of the distal parts of the bilateral lower limbs a week after his upper @entity6 , followed by the weakness with the legs and paresthesia with the lip area, tongue and finger tips. Those symptoms gradually became worse to the point that he was unable to walk 10 days later. Although @entity7 , @entity1 , and lymph node swelling were not found, we made a diagnosis of @entity9 ( @entity9 ) because of clinical features of @entity3 , @entity11 , @entity4 , elevated plasma level of @entity2 ( @entity2 ) and @entity10 in his abdomen. Following intravenous immunoglobulin therapy (IVIg), he showed marked improvement. However, his neurologic symptoms deteriorated acutely just after open biopsy together with the elevation of @entity2 level, and a few days later he was in the state of flaccid @entity5 . We tried IVIg therapy again and his neurologic symptoms were markedly improved. We speculated that an elevated @entity2 , released from plasma cells induced by the bioprocedure, might have caused an increase in microvascular permeability and affected the blood-nerve-barrier, thereby his neurologic symptoms deteriorated. It is thought that this case may support the hypothesis that a significant role is played by @entity2 in the pathomechanism of the development of @entity9 . Additionally we experienced that IVIg was very effective to the neurologic symptoms, and we think that IVIg will be able to be one of the future therapy of the @entity9 . To our knowledge, there has been no report of @entity9 which manifested acute deterioration of his neurologic symptoms just after open biopsy with acute onset with @entity8 like symptoms.

title: [A case of XXXX with @entity10 : marked clinical deterioration following a biopsy to plasmacytoma].

answer: @entity9


abstract: OBJECTIVE: The timing of antipsychotic discontinuation in @entity0 who have fully recovered from their initial episode of @entity2 is still open to discussion. We aimed to evaluate the risk of symptom recurrence during the 3 years after antipsychotic discontinuation in a sample of functionally recovered first-episode nonaffective @entity2 (FEP) @entity0 (DSM-IV criteria) with @entity1 spectrum disorder. METHOD: @entity0 in this open-label, nonrandomized, prospective study were drawn from an ongoing longitudinal intervention program of FEP from a university hospital setting in Spain. From July 2004 to February 2011, functionally recovered FEP individuals were eligible if they met the inclusion criteria of (1) a minimum of 18 months on antipsychotic treatment, (2) clinical remission for at least 12 months, (3) functional recovery for at least 6 months, and (4) stabilization at the lowest effective doses for at least 3 months. Forty-six individuals who were willing to discontinue medication were included in the discontinuation group (target group). Twenty-two individuals opted to stay on the prescribed antipsychotic medication and therefore were included in the maintenance group (control group). Primary outcome measures were relapse rate at 18 and 36 months and time to relapse. RESULTS: The rates of relapse over the 3-year period were 67.4% (31 of 46) in the discontinuation group and 31.8% (7 of 22) in the maintenance group. The mean time to relapse was 209 (median = 122) days and 608 (median = 607) days, respectively (log rank = 10.106, P = .001). The resumption of antipsychotic medication after the relapse occurred was associated with clinical stability and lack of further relapses. When the overall group of relapsed individuals from the 2 conditions (N = 38) was compared to those who remained asymptomatic after 3 years (N = 30), there were significant differences (P < .05) in total scores on the Scale for the Assessment of Negative Symptoms, the Clinical Global Impressions scale, and the Disability Assessment Schedule. CONCLUSIONS: Antipsychotic treatment discontinuation in individuals who had accomplished a functional recovery after a single @entity2 was associated with a high risk of symptom recurrence. Relapsed individuals had a greater severity of symptoms and lower functional status after 3 years. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02220504.

title: Clinical outcome after antipsychotic treatment discontinuation in functionally recovered first-episode nonaffective XXXX individuals: a 3-year naturalistic follow-up study.

answer: @entity2


abstract: UNASSIGNED: The present study aimed to evaluate the clinical outcome of using a hyoid osteomuscular flap to repair the laryngeal defect after extended vertical partial laryngectomy. A total of 26 glottic @entity1 @entity0 underwent reconstruction with osteomuscular hyoid flaps following @entity1 resections. Ipsilateral arytenoid cartilage was resected in all cases, and the upper region of the cricoid cartilage was resected in 11 cases. Selective ipsilateral level II, III and IV neck dissections were performed in node (N)-positive @entity0 and ipsilateral level II, and III neck dissections in N0 @entity0 . The bone grafts were then fixed to the cricoid and contralateral thyroid cartilages. Invasion of the thyroid cartilage endochorium was present in 12 cases and lymph nodes metastases was present in 11 cases. The extubation rate of the tracheostomy tube was 100%. The glottides of all @entity0 were almost symmetrical. @entity0 were followed up for 2-7 years. One @entity0 developed local recurrence, ipsilateral regional recurrence, contralateral regional recurrence and lung metastasis, respectively. The disease-free survival rates at 3 and 5 years were 100% (20/20) and 79% (11/14), respectively. Overall, laryngeal function recovered well upon hyoid osteomuscular flap reconstruction following extended vertical partial laryngectomy, with a high extubation rate and good sound quality.

title: Laryngeal function reconstruction with hyoid osteomuscular flap in partial laryngectomy for XXXX .

answer: @entity1


abstract: The suggested methods of the formation of intubation @entity2 as well as @entity1 in the area of posterior vocal ligament insertion have been controversial. One reason for divergent opinions is possibly based on different judgements of morphology in this region. The present study analyzed structures of the vocal ligament and vocalis muscle insertion at the vocal process by means of histological, immunohistochemical and electron microscopic methods. Investigations were performed in three planes on the vocal cords of 22 @entity0 and 19 @entity0 (aged 21-97 years). Inside the insertion zone of the vocal ligament at the vocal process three structures could be distinguished: hyaline cartilage at the base of arytenoid cartilage, elastic cartilage at its apex and the posterior elastic nodule in front of them. No perichondrium could be seen around the elastic nodule. In elastic nodules type I and type III collagen fibrils as well as elastic fibers formed a scissor-like meshwork around large fibroblasts. The vocalis muscle inserted at the perichondrium in the lateral part of the arytenoid skeleton by short tendons. At the insertion zone blood vessels of the vocalis muscle penetrated the perichondrium and reached the cartilaginous matrix. At the beginning of osteogenesis, the blood vessels connected with intraosseous blood vessels of the arytenoid. Connective tissue cells of the insertion zone and extracellular matrix components formed by these cells fulfilled a biomechanical function by equalizing the different elastic moduli of tendon, cartilage or bone. The lack of perichondrium around the lengthened posterior elastic nodule made formation of intubation @entity2 caused by @entity3 in this area impossible. Loosened perichondrium or periosteum in the area of the insertion of the vocalis muscle at the vocal process, ossification and associated vascularization of the arytenoid skeleton permitted invasion of @entity1 into the arytenoid.

title: Functional and clinical anatomy of the posterior insertion of the XXXX vocal ligament.

answer: @entity0


abstract: The effects of stimulating the intramural nerves on the membrane potential and tension in the uterine artery of virgin @entity0 were compared with the responses during pregnancy. In all tissues the amplitude of the excitatory junction potential (EJP) increased as the stimulus voltage was increased. The rate of increase in EJP amplitude in tissues from virgin animals greatly exceeded that recorded in late pregnant tissues. EJPs were abolished by @entity1 but were resistant to blockade by alpha-adrenoceptor antagonists. Stimulation of the nerves also evoked a slow depolarization and contraction which were abolished by both @entity1 and alpha-adrenoceptor antagonists. The amplitudes of the depolarizations and contractions were not correlated. The role of EJPs and alpha-adrenoceptor activation in the control of vascular function is discussed. Fluorescence histochemistry revealed a decrease in the density of the @entity2 innervation that was correlated with a decrease in @entity2 content as pregnancy progressed. In addition, there appeared to be a difference in the arrangement of the fluorescent varicosities, with a shift from varicosities that were close to the outer layer of smooth muscle in virgin tissues to those that were more distantly dispersed in the adventitia during late pregnancy. The changes would be expected to reduce the effectiveness of vasoconstrictor drive to the uterine artery as pregnancy progresses.

title: Pregnancy-induced decrease in evoked excitatory junction potentials in XXXX uterine artery.

answer: @entity0


abstract: UNASSIGNED: Background: The histopathology of the muscularis propria (MP) is unknown in @entity0 with @entity3 . Endocytoscopy (EC) was developed as an ultra-high magnification endoscopy, and the submucosal tunnel created during peroral endoscopic myotomy (POEM) not only provides access to the MP but also enables subsequent endoscopic assessment of the MP. @entity0 and methods: In seven @entity0 with @entity3 (mean  SD; 35  18.1 years; @entity0 : @entity0 , 4:3) who underwent POEM (myotomy length: 12  2.2cm), subsequent EC examination was performed from the mid-esophagus to the gastric side. EC images were compared to the results of histopathologic examination (two biopsies from the mid-esophagus and lower esophageal sphincter), which was the standard. Results: In all @entity0 , favorable EC images were obtained, and spindle-shaped smooth muscle cells were detected. In our series, we observed no notable features such as @entity1 or @entity2 of smooth muscle cells. In addition, the EC assessment was consistent with the results of biopsy. No complications were encountered during any of the procedures. Conclusion: In a clinical setting, real-time assessment of the MP using EC is feasible. This technique may play an important role in determining the pathology of @entity3 and other diseases that affect gastrointestinal function.

title: In vivo histopathological assessment of the muscularis propria in XXXX by using endocytoscopy (with video).

answer: @entity3


abstract: BACKGROUND: Reliable risk scoring systems that can predict the severity of @entity2 are necessary to implement effective management strategies in high risk @entity0 . @entity3 and with @entity1 and mortality risk are @entity0 who would benefit most from a change in @entity0 with high risk factors. Framingham Risk Score, the Prospective Cardiovascular M  nster score and Systematic Coronary Risk Evaluation risk scores are used for this purpose. The severity of the @entity2 as detected by coronary angiography can be estimated using the syntax score. In this study, it's aimed to assess the relation between syntax score and the Framingham, Prospective Cardiovascular M  nster and Systematic Coronary Risk Evaluation scores in the context of their utility for the determination of the severity of the @entity2 . METHODS: A total of 205 @entity0 with documented @entity2 who underwent coronary angiography due to a diagnosis of @entity4 were included in this study. Coronary risk scores were determined for each @entity0 . The relation between the syntax score and the results of coronary risk scoring systems were analyzed. RESULTS: A positive relation between the syntax score, which reflects the severity of the @entity2 and coronary risk scores was found. However, Framingham and Systematic Coronary Risk Evaluation were superior, ie, had more predictive value, in terms of their ability to predict the syntax score (p = 0.029, 0.033 and 0.002, respectively). CONCLUSIONS: Examination of the distribution of syntax score across low, intermediate and high risk groups showed a significantly higher predictive value of Systematic Coronary Risk Evaluation for high risk @entity0 (p=0.005).

title: Comparison of coronary risk scoring systems to predict the severity of XXXX using the SYNTAX score.

answer: @entity2


abstract: Studies have demonstrated that hyperhomocyst(e)inemia is present in renal transplant recipients and is correlated with @entity1 . It is still unclear whether hyperhomocyst(e)inemia observed in renal transplant recipients solely depends on the moderate reduction of renal function in these @entity0 or if additional mechanisms are operative in this @entity0 category. A recent study suggested that @entity2 (CsA) increased plasma homocyst(e)ine concentration in interfering with @entity6 -assisted remethylation of @entity5 . To confirm this hypothesis, we studied plasma homocyst(e)ine @entity6 and @entity7 concentrations in 122 renal transplant recipients (104 on CsA and 18 not receiving CsA). After adjusting for age, gender, transplant duration and serum @entity4 concentration, @entity0 with and without CsA had similar plasma homocyst(e)ine concentrations (17.9 +/- 6.1 mumol/l in CsA(+) @entity0 vs 17.1 +/- 5.6 mumol/l in CsA(-) @entity0 ; p = 0.3). Moreover, we found a significant inverse relationship between plasma homocyst(e)ine and @entity6 concentrations in both CsA(+) (r = 0.218; p < 0.01) and @entity3 (r = -0.678; p < 0.05) @entity0 . @entity0 with a past history of cardiovascular incidents had higher plasma homocyst(e)ine concentrations than those without cardiovascular antecedent (20.5 +/- 7.8 mumol/l vs. 18.01 +/- 9.9 mumol/l; p < 0.05. To conclude: 1, We did not find any influence of CsA on plasma homocyst(e)ine concentrations. 2. We demonstrated that as in other @entity0 category, plasma @entity6 and homocyst(e)ine concentrations are significantly correlated in CsA(+) @entity0 . 3. Homocyst(e)ine-lowering therapy would be prescribed in CsA(+) @entity0 to allow correction of hyperhomocyst(e)inemia.

title: Hyperhomocyst(e)inemia in renal transplant recipients with and without XXXX .

answer: @entity2


abstract: AIM: @entity1 ( @entity1 ) is often responsible for @entity2 , drug withdrawal, boxed warnings or drug non-approval. Therefore, we conducted a case-control study to determine the hepatotoxic risk of a wide range of drugs. METHODS: The Berlin Case-Control Surveillance Study FAKOS included all 51 Berlin hospitals in a hospital network. Between 2002 and 2011, 198 @entity0 with acute idiopathic @entity1 , 377 inpatient controls and 708 outpatient controls were ascertained. Case @entity0 were thoroughly validated using anamnestic, clinical, laboratory, and histological data. Drug exposure was obtained in a face-to-face interview. A possible drug aetiology was assessed in individual @entity0 by applying the updated Council for International Organizations of Medical Sciences (CIOMS) scale. Drug risks were further quantified [odds ratios (OR) with 95% confidence intervals (CI)] in a case-control design with unconditional logistic regression analysis. Drug intake in the last 28 days before index date was considered for the analysis. RESULTS: The study corroborated hepatotoxic risks for a number of drugs, including phenprocoumon (OR: 3.3, 95%CI: 1.5-6.7), @entity4 (OR: 5.5, 95%CI: 1.3-21.2), @entity3 (OR: 34.6, 95%CI: 2.8-824.9), and @entity5 (OR: 40.2, 95%CI: 5.5-856.9). Increased risks were also suggested for less commonly reported substances such as angiotensin II-receptor blockers, atypical antipsychotics and for biperiden, a drug never before reported to be hepatotoxic. CONCLUSIONS: Our study identified a large number of drugs as possible causes of hepatotoxicity. The observed risk for seldom reported substances highlights the need for further postauthorisation safety studies not exclusively focussing on drugs already labelled as potentially hepatotoxic.

title: XXXX : results from the hospital-based Berlin Case-Control Surveillance Study.

answer: @entity1


abstract: BACKGROUND: Various measures/scales have been used to assess oral health-related quality of life in @entity0 with @entity3 ( @entity3 ). However, there have been few reports on the validity of questionnaires, and even fewer assessments of their use in Japanese sociocultural conditions. OBJECTIVES: The objectives of the study were: (i) to develop and refine the number of questions concerning @entity1 -related limitations of daily function in the @entity4 questionnaire (LDF-TMDQ, 13 items) in Japanese @entity0 with @entity4 , (ii) to assess factor validity, and (iii) to determine convergent and discriminant validity of the LDF-TMDQ with the observed items within a multidimensional questionnaire. METHODS: Four hundred and fifty-six (85.9%) outpatients with @entity4 were enrolled. The subjects were allocated into two roughly equal groups--E-group (233) for exploratory factor analysis and C-group (223) for confirmatory factor analysis [ @entity2 ( @entity2 )]. RESULTS: The exploratory factor analysis extracted 10 items and three factors. @entity2 showed the revised model to accurately describe the relationships between the measured items. As to convergent validity, the factor 'limitation in executing a certain task' and 'limitation of mouth opening' showed significant correlations with the observed items within the multi-dimensional questionnaire. However, the factor 'limitation of sleeping', show no correlation with any item. As to discriminant validity, all three factors had correlation coefficients below 0.4 with the psychological scale, the personality scale, and the visual analog scale for @entity1 intensity. CONCLUSION: The LDF-TMDQ was reduced from 13 items to 10. The factor validity of the LDF-TMDQ, and the construct validity of 'limitation in executing a certain task' and 'limitation of mouth opening' were confirmed, while that of 'limitation of sleeping' remains to be determined.

title: Development of a new questionnaire to assess XXXX -related limitations of daily functions in Japanese @entity0 with @entity3 .

answer: @entity1


abstract: BACKGROUND: Early detection of @entity1 has a major impact on further management and outcome in acute @entity2 . The aim of this study was to evaluate the clinical value of ultrasonographically guided fine-needle aspiration cytology (FNAC) in @entity0 with @entity2 over an 8-year period. METHODS: From January 1988 to September 1996 193 (mean 2.0 (range 1-9) @entity3 per @entity0 ) prospectively assessed FNACs guided ultrasonographically were performed in 98 @entity0 with @entity2 proven by contrast-enhanced computed tomography. Aspirates were considered infected if either Gram stain and/or culture revealed micro-organisms. RESULTS: Ultrasonographically guided FNAC correctly diagnosed infection in 29 of 33 @entity0 with infected @entity1 a median of 13 days after onset of symptoms. Of 61 @entity0 with sterile @entity1 55 were identified correctly as sterile by FNAC. There were six false-positive and four false-negative aspirates of which nine occurred during the first week of the disease. In four @entity0 who did not undergo operation FNAC revealed Gram-negative organisms; however, in the absence of repeated @entity3 , the positive results remained unconfirmed. An overall sensitivity of 88 per cent and a specificity of 90 per cent was obtained. No difference was found in biochemical and clinical parameters indicating @entity4 before each FNAC between @entity0 with proven sterile or infected @entity1 . All @entity0 tolerated the procedure well and no major complications were observed. CONCLUSION: Ultrasonographically guided FNAC is a fast and reliable technique for the diagnosis of infected @entity1 . As complication rates are very low, the procedure can be repeated at short intervals to improve the diagnostic accuracy. Ultrasonographically guided FNAC is recommended for all @entity0 with @entity2 in whom @entity4 persists beyond the first week after onset of symptoms.

title: Role of ultrasonographically guided fine-needle aspiration cytology in the diagnosis of XXXX .

answer: @entity1


abstract: OBJECTIVES: To assess 12-month changes in nutritional status and quality of life (QoL) in @entity3 ( @entity3 ) @entity0 requiring @entity5 ( @entity5 ). METHOD: We conducted a retrospective, single-centre database analysis of @entity3 @entity0 regarding a 12-month period of @entity5 at an interdisciplinary University Unit/team for nutrition and @entity2 . Nutritional status was analysed by nutritional risk screening (NRS) and body mass index (BMI). QoL was evaluated using Short-Form Health Survey (SF-36) questionnaires. RESULTS: Between 2008 and 2013, daily nocturnal @entity5 was initiated in five consecutive @entity3 @entity0 (four females and one male, mean age 62.2  years) suffering severe @entity5 due to gastrointestinal tract (GIT) involvement. After 12  months of @entity5 , the mean NRS score decreased from 4.4 (range 4-5) to 1.4 (range 1-2), the mean BMI increased from 19.1 (range 17.4-20.3) to 21.0  kg/m(2) (range 18.3-23.4). QoL improved in all @entity0 , reflected by the summary of physical components with 33.92 points before vs. 67.72 points after 12  months of @entity5 , and the summary of mental components with 49.66 points before vs. 89.27 points after 12  months of @entity5 . Two @entity0 suffered one @entity4 each with subsequent surgical removal and reinsertion. CONCLUSIONS: @entity5 is a feasible method for improving anthropometric parameters and QoL in @entity3 @entity0 severely affected by @entity1 . We recommend @entity5 in malnourished, catabolic @entity3 @entity0 unable to otherwise maintain or improve their nutritional status.

title: Home parenteral nutrition is beneficial in @entity3 @entity0 with XXXX .

answer: @entity1


abstract: OBJECTIVE: To compare two treatment strategies in @entity0 undergoing surgery for @entity3 . DESIGN: Retrospective cohort study. SETTING: Tertiary care center. POPULATION: A total of 1166 @entity0 . Uterine biopsy/curettage was obtained in 1140 @entity0 , of whom 229 also had pelvic magnetic resonance imaging (MRI). METHODS: We compared two strategies: 1) routine pelvic lymphadenectomy, 2) selective pelvic lymphadenectomy for @entity0 with @entity2 according to preoperative histology and MRI. High-risk @entity2 included grade 1-2 @entity4 with >= 50% myometrial invasion, grade 3 @entity4 , and @entity2 . Others were considered @entity2 . MAIN OUTCOME MEASURES: Diagnostic indices, treatment algorithms. RESULTS: Of the @entity0 who underwent lymphadenectomy, positive pelvic nodes were found in 2.3% of @entity2 and 18.3% of @entity2 . The combination of preoperative histology and MRI detected @entity2 with a sensitivity of 85.7%, specificity of 75.0%, positive predictive value of 74.4%, and negative predictive value of 86.1%. Area under curve was 0.804. In the routine lymphadenectomy algorithm, 54.1% of lymphadenectomies were performed for @entity2 . In the selective lymphadenectomy algorithm, 14.3% of @entity0 with @entity2 did not receive lymphadenectomy. Missed positive pelvic nodes were estimated to occur in 2.1% of @entity0 in the selective strategy. Similarly, the estimated risk for isolated para-aortic @entity1 was 2.1%, regardless of treatment strategy. CONCLUSIONS: The combination of preoperative histology and MRI is moderately sensitive and specific in detecting high-risk @entity3 . The clinical utility of the method is hampered by the relatively high proportion of high-risk cases that remain unrecognized preoperatively. This article is protected by copyright. All rights reserved.

title: Combined use of endometrial sample and magnetic resonance imaging in the preoperative risk-stratification of XXXX .

answer: @entity3


abstract: 1. The antagonism at alpha-adrenoceptors by @entity3 and @entity2 of the response to @entity1 was investigated in the limb veins and arteries of @entity0 .2. Brachial artery infusions of @entity3 (40 mug/min) produced rises in resting arterial flow of up to 100%. When infused mixed with @entity1 , @entity3 (40 mug/min) attenuated the blood flow response to @entity1 . Blockade was of a similar degree to that which occurred following a 10 min infusion of @entity2 (40 mug/min).3. Local intravenous infusion of @entity3 (400-2,000 ng/min) mixed with @entity1 attenuated the venoconstrictor response to @entity1 . The degree of attenuation was similar to that seen after a 10 min infusion of @entity2 (500 ng/min). Blockade after @entity3 did not last longer than 16 minutes. Neither @entity3 nor @entity2 altered resting venous compliance.4. Local intravenous infusions of @entity3 (500 ng/min) and @entity2 (500 ng/min) abolished the sympathetically mediated venoconstriction produced by overbreathing.5. Systemic injection of @entity3 (0.1 mg/kg) did not block the reduction in forearm arterial flow produced by locally infused @entity1 . In two out of three experiments, however, it produced some antagonism of @entity1 induced venoconstriction. Systemic @entity2 (5 mg) blocked the effect of @entity1 in the arterial bed, but antagonized its actions in the veins in only one out of three experiments.

title: Comparison of blockade at alpha-adrenoceptors by @entity3 and XXXX in peripheral arteries and veins of @entity0 .

answer: @entity2


abstract: Although @entity9 (SAMe) has beneficial effects in many @entity2 , the effects of SAMe on acute @entity3 -induced @entity2 are unknown. In the present study, we investigated effects of SAMe on @entity2 in @entity0 induced by acute @entity3 administration. Male C57BL/6 @entity0 received @entity4 (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. SAMe (5 mg/kg BW) was administrated i.p. once a day for three days before @entity4 administration. Subsequent serum @entity8 level, hepatic lipid peroxidation, enzymatic activity of @entity10 and hepatic mitochondrial @entity6 levels were measured colorimetrically. Intracellular SAMe concentration was measured by high-performance liquid chromatography (HPLC). Histopathological changes were assessed by H_E staining. Our results showed that acute @entity4 administration caused prominent @entity5 with mild @entity1 and an elevation of serum @entity8 activity. SAMe treatment significantly attenuated the @entity2 . In association with the hepatocyte injury, acute @entity3 administration induced significant @entity2 and mitochondrial @entity7 levels along with enhanced lipid peroxidation. SAMe treatment attenuated hepatic SAMe and mitochondrial @entity7 depletion and lipid peroxidation following acute @entity3 exposure. These results demonstrate that SAMe protects against the @entity2 and attenuates the mitochondrial @entity7 depletion caused by acute @entity3 administration. SAMe may prove to be an effective therapeutic agent in many toxin-induced @entity2 including those induced by @entity3 .

title: @entity9 (SAMe) protects against acute @entity3 induced hepatotoxicity in XXXX .

answer: @entity0


abstract: Background. @entity1 results from autoimmune destruction of b-cells. Insulin-producing cells (IPCs) differentiated from mesenchymal stem cells (MSCs) in @entity0 tissues decrease blood @entity3 levels and improve survival in @entity1 @entity2 . We compared the differential ability and the curative effect of IPCs from three types of @entity0 tissue to determine the ideal source of cell therapy for @entity1 . Methods. We induced MSCs from Wharton's jelly (WJ), bone marrow (BM), and surgically resected pancreatic tissue to differentiate into IPCs. The in vitro differential function of these IPCs was compared by insulin-to-DNA ratios and C-peptide levels after @entity3 challenge. In vivo curative effects of IPCs transplanted into @entity1 @entity2 were monitored by weekly blood @entity3 measurement. Results. WJ-MSCs showed better proliferation and differentiation potential than pancreatic MSCs and BM-MSCs. In vivo, WJ-IPCs significantly reduced blood @entity3 levels at first week after transplantation and maintained significant decrease till week 8. BM-IPCs reduced blood @entity3 levels at first week but gradually increased since week 3. In resected pancreas-IPCs group, blood @entity3 levels were significantly reduced till two weeks after transplantation and gradually increased since week 4. Conclusion. WJ-MSCs are the most promising stem cell source for b-cell regeneration in @entity1 treatment.

title: Comparisons of Differentiation Potential in XXXX Mesenchymal Stem Cells from Wharton's Jelly, Bone Marrow, and Pancreatic Tissues.

answer: @entity0


abstract: UNASSIGNED: 61 Background: @entity0 survivor numbers are increasing due to population aging and improved treatment outcomes but many of their long-term health care needs are unmet. Integrated follow-up care strategies that enhance care coordination, education, and access to survivorship resources are needed to provide @entity1 with evidence-based care that addresses medical and psychosocial needs after @entity2 treatment. METHODS: In 2008, we established the Johns Hopkins @entity0 Survivorship Program with representation from the Schools of Nursing, Public Health, and Medicine to address the needs of @entity1 completing initial @entity2 treatment and transitioning to long-term follow-up. @entity1 educational resources were created within an interactive website ( http://bit.ly/hZfzFi ) including > 35 @entity1 /provider educational video clips, blogs and social media. Activities including provider educational events, educational folders, and trainee curriculum additions have been ongoing. Starting May 2011, Hopkins @entity1 were offered a one-time transition visit with a nurse practitioner focusing on individualized treatment summary/survivorship care plan activities (e.g., @entity2 screening/surveillance, medical intervention, psychosocial support, and care coordination with non- @entity2 providers). RESULTS: Our website is averaging 3,000 hits monthly. We have participated in 22 provider/trainee formal educational presentations. In the pilot phase of these transition visits (n=40), age/race breakdown of @entity1 were representative of our @entity0 population (median age 51, range 34-69; 17% African Americans). Our post-visit survey (n=37), 97% found the survivorship visit beneficial and all reported that this one-time consultation helped with transitioning away from treatment. CONCLUSIONS: A multidisciplinary @entity1 -centered approach to @entity0 survivorship allowed us to develop comprehensive clinical and educational service models to benefit @entity1 and their @entity2 /non- @entity2 providers. This program aims to enhance education, overcome the fragmentation of the health care system, and improve overall health and wellness of @entity0 survivors as they transition to long-term survivorship.

title: Making it work: XXXX survivorship care at Johns Hopkins.

answer: @entity0


abstract: OBJECTIVE: To observe the efficacy and safety of subconjunctival @entity4 injections in the treatment of @entity2 ( @entity2 ). METHODS: A retrospective case series study. The clinical data of @entity3 @entity0 with @entity2 were collected and analyzed at Peking Union Medical College Hospital from July 2009 to June 2014 with a minimum follow-up period of 6 months. The main outcome was @entity1 ( @entity1 ) measured by optical coherence tomography at the 1st and the 3rd month after injection. The secondary outcomes included best corrected visual acuity (BCVA) at the 1st and the 3rd month, recurrence rate and intraocular pressure (IOP) within 6 months after injection. RESULTS: Thirty two @entity0 (37 eyes) were included in the study. At the 1st month after the first injection, 24 of the 37 eyes (64.9%) showed an obvious reduction of @entity1 (at least 20%), among them 15 eyes (40.5%) showed a total resolution. The mean @entity1 decreased from (498.9    211.9)   m at baseline to (392.4    232.3)   m (t = -4.070, P < 0.01). The BCVA improved in 20 eyes (54.1%) and 15 eyes (40.5%) gained more than 0.2 log MAR unit. The mean BCVA increased from logMAR, 0.45    0.29 at baseline to logMAR, 0.33    0.30 (t = -4.835, P < 0.01). No statistically significant difference was found in mean @entity1 or BCVA in 23 eyes between the 1st and the 3rd month after injection. These eyes didn't receive any additional medications for improvement of the condition. Seven eyes (30.4%, 7/23) got a second injection because of relapse within 6 months after the first injection and the efficacy was good. The elevation of IOP over 21 mmHg (1 mmHg = 0.133 kPa) were observed in 9 eyes and 3 eyes after the first and the second injection respectively. All of them were well controlled by either topical IOP lowering drugs or removal of the subconjunctival TA deposition. CONCLUSION: Subconjunctival injection of @entity4 is an effective and safe method for @entity2 .

title: [The efficacy and safety of subconjunctival XXXX injections in treatment of @entity2 ].

answer: @entity4


abstract: In order to evaluate a structured support intervention programme, symptoms and quality of life (QOL) were studied in 61 consecutive @entity1 @entity0 with different @entity1 diagnoses in relation to intervention and follow-up. The majority of the @entity0 were female. The Edmonton symptom assessment scale (ESAS), the @entity4 and the hospital @entity2 and @entity3 scale (HADS) were used. Data were analysed according to ANOVA and Tukey's @entity5 ( @entity5 ) test. ESAS sickness score (P=0.0001), @entity3 (P=0.0001), @entity2 (P=0.0001) and QOL (P=0.0009) improved and the improvements in @entity3 and @entity2 were still significant after 3 months (P=0.02 respectively). Aspects of @entity4 also improved significantly in 7 of 11 questions after the intervention (P< or =0.04) but these improvements were not observed after 3 months. @entity2 according to the HADS questionnaire improved significantly after the intervention (P=0.0006). The majority of the @entity0 highly appreciated the possibility of sharing thoughts and troubles with others with similar experiences (59%). The programme was therefore found to improve QOL, and physical and psychological functions. Randomized studies in relation to immunological changes and follow-up are in progress.

title: Support group for XXXX @entity0 . Does it improve their physical and psychological wellbeing? A pilot study.

answer: @entity1


abstract: STUDY DESIGN: A cross-sectional and prospective study of @entity7 . OBJECTIVES: To investigate the correlation between @entity5 or history of @entity1 , back function, @entity3 , and @entity4 . BACKGROUND: It has been postulated that @entity6 may compromise blood flow to bone and soft tissues in the back, causing @entity2 and disability. Recent studies have presented conflicting results. METHODS: At baseline, information on back @entity2 and function, general functional status, cardiovascular history, and general lifestyle variables was obtained from 1492 elderly white @entity0 (mean age, 71 years) enrolled in the Study of @entity7 . Lateral radiographs of the lumbar and thoracic spine were obtained, and @entity5 was assessed. Follow-up information was obtained an average of 3.7 years later. RESULTS: At baseline, 82 @entity0 had @entity5 , 443 had a history of @entity1 , and 277 had @entity4 ; 58 @entity0 had one or more additional @entity4 during the follow-up period. After adjustment for age, @entity0 with @entity1 were more likely to have back @entity2 and disability as a result of the back @entity2 than @entity0 free of @entity1 ; at the follow-up examination, the back-related disability was more than twice as likely to have worsened in the @entity1 group. No correlation was found between @entity5 . Neither the prevalence of @entity4 at baseline, nor the incidence of @entity4 was associated with the presence of @entity5 or @entity1 . CONCLUSIONS: Results indicated that back problems in elderly @entity0 are associated with self-reported @entity1 , but not with objectively assessed @entity5 .

title: Back problems and @entity6 . The Study of XXXX .

answer: @entity7


abstract: BACKGROUND: More than 1 million @entity0 live, play, and work on farms, surrounded by animals and machinery. This symbiotic relationship between work and home exposes @entity0 to unique risks. METHODS: @entity0 presenting with a farm-related injury (November 1994 to August 2001, 82 months) were included. @entity1 registry parameters included @entity1 score (ISS); Glascow @entity4 Scale (GCS); time to presentation; season and day of @entity1 , intensive care unit, and total length of stay type; and mechanism of injury; and operations. RESULTS: A total of 1,832 pediatric @entity1 @entity0 were evaluated. Ninety-four @entity0 were identified with farm-related @entity1 . Mean age was 10.75 years. Mean ISS was 7.38. Three @entity0 died. Four @entity0 wore protective equipment. Forty-four percent of @entity1 occurred during summer, 31% during spring, and 55% on weekends. Average time to initial presentation was 39 minutes. A total of 177 minutes elapsed before transfer to regional @entity1 center. Seventy-two @entity0 required admission. LOS was 0 to 28 days, mean, 2.76 days. Twenty-six @entity0 (28%) required operations. Injuries included dislocations/ @entity3 (52%), lacerations/ @entity2 (38%), concussions (31%), contusions (30%), and burns (14%). Mechanism included animals (41%), falls (34%), motor vehicles (28%), all-terrain vehicles (20%), and firearms (4%). CONCLUSIONS: @entity1 occur most commonly during weekends, summer, and spring months, resulting in significant morbidity. Most @entity1 required hospitalization. Unless unstable, initial transfer to a regional pediatric @entity1 center should result in the most cost-effective, prompt, and highest quality of care.

title: Life on the farm- XXXX at risk.

answer: @entity0


abstract: INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible alternative to electroconvulsive therapy for the treatment of selected @entity0 with @entity3 , @entity2 and @entity1 . The aim of this study was to evaluate the evidence for the effectiveness of rTMS in @entity4 and @entity1 . METHODS: Studies were identified using MEDLINE (1966 to January 2000), EMBASE/Excerpta Medica (1980 to January 2000), Biological Abstracts and Index to Scientific and Technical Proceedings. A number of biomedical and TMS related websites were also searched. We estimated the number needed to treat to show beneficial effect of rTMS when compared with the placebo controlled group. RESULTS: Seven controlled trials of rTMS @entity3 were identified. Five of these were suitable for meta-analysis and show a beneficial effect of rTMS compared to placebo, with a number needed to treat of 2-3 with a 95 % confidence interval 1.6 to 4.0, total; 81 @entity0 . A single trial of rTMS has also been performed in @entity2 , which shows a beneficial effect of right hemisphere stimulation when compared with left hemisphere stimulation. A controlled trial in @entity1 failed to show any benefit of rTMS. DISCUSSION: rTMS has demonstrable beneficial effects in @entity3 . The extent and the duration of the anti-depressant effect of rTMS has yet to be defined. There now needs to be randomized controlled trials to compare rTMS directly with standardized electroconvulsive therapy in order to take this subject forward. With regard to the treatment of other @entity4 and @entity1 , we are at an early stage in the assessment of further studies that are needed to examine any potential role for rTMS.

title: Transcranial magnetic stimulation for XXXX and other psychiatric disorders.

answer: @entity3


abstract: 1. The detergent @entity4 activates @entity2 glucuronyltransferase from @entity0 liver in vitro six- to seven-fold with @entity5 as substrate. The enzyme activity when measured in the presence of @entity4 is increased significantly by pretreatment of male @entity0 with @entity1 for 4 days (90mg/kg each day intraperitoneally). If no @entity4 is applied in vitro such an increase could not be shown. In all further experiments the enzyme activity was measured after activation by @entity4 . 2. The K(m) of the enzyme for the substrate @entity5 does not change on @entity1 pretreatment. 3. When the microsomal fraction from the liver of untreated @entity0 is subfractionated on a @entity3 density gradient, 47% of the enzyme activity is recovered in the rough-surfaced microsomal fraction, which also has a higher specific activity than the smooth-surfaced fraction. 4. Of the increase in activity after the @entity1 pretreatment 50% occurs in the smooth-surfaced fraction, 19% in the rough-surfaced fraction and 31% in the fraction located between the smooth- and rough-surfaced microsomal fractions on the sucrose density gradient. 5. The latency of the enzyme in vitro, as shown by the effect of the detergent @entity4 , is discussed in relation to the proposed heterogeneity of @entity2 glucuronyltransferase.

title: The effect of XXXX on the submicrosomal distribution of @entity2 glucuronyltransferase from @entity0 liver.

answer: @entity1


abstract: UNASSIGNED: @entity2 is one of the most common diseases and is a leading cause of @entity0 in developing countries. This is often caused by contaminated food. Poor food hygiene standards are exacerbated by the presence of flies which can transmit a variety of infectious microorganisms, particularly through animal source foods. This fact becomes especially important in developing countries like Zambia, where fish is a highly valued source of protein. Our interest in this study was to identify if the flies that beset food markets in Zambia carry important pathogenic bacteria on their bodies, and subsequently if these bacteria carry resistance genes to commonly used antibiotics, which would indicate problems in eradicating these pathogens. The present study took into account fish vendors' and consumers' perception of flies and interest in interventions to reduce their numbers. We conducted semi-structured interviews with (1) traders (comprised of randomly selected males and females) and (2) consumers (including randomly selected males and females). Thereafter, we collected flies found on fish in markets in Mongu and Lusaka districts of Zambia. For the entire study, a total of 418 @entity1 samples were analyzed in the @entity4 spp. and enteropathogenic @entity3 were isolated from the flies. Further laboratory screening revealed that overall, 17.2% (72/418) (95% CI; 43.2%-65.5%) of total samples analyzed contained @entity5 (ESBL)-producing @entity3 . These significant findings call for a strengthening of the antibiotic administering policy in Zambia and the development of sustainable interventions to reduce @entity1 numbers in food markets and improve food safety and hygiene.

title: Antimicrobial Resistant Enteropathogenic XXXX and Salmonella spp. in Houseflies Infesting Fish in Food Markets in Zambia.

answer: @entity3


abstract: AIM: @entity5 @entity1 (BKVN) is an important complication in kidney transplantation. After immunosuppressive agents are reduced, some @entity0 experience a temporal increase in serum @entity4 (sCr) before viral clearance. The histological characteristics of re-biopsies were therefore investigated to evaluate the time course of remission. METHODS: sCr was measured and urinary cytology evaluated periodically in 14 @entity0 with biopsy-proven BKVN. Remission of BKVN was defined as re-biopsies negative for SV40 large T antigen (SV40-TAg) or for decoy cells on at least three consecutive cytology tests. Early changes in sCr were correlated with re-biopsy findings. RESULTS: Mean sCr was 1.6        0.6   mg/dL at diagnosis, increasing during the first 2 months to 2.6        2.0   mg/dL, and decreasing thereafter, to 2.3        1.2   mg/dL at 3-4 months. Two @entity0 who experienced further increases in sCr at 3 months showed early graft loss, while the others showed clinical or histological remission. Nineteen re-biopsies were obtained from eight @entity0 over 4 months. Banff i-scores were higher in re-biopsies obtained during the first 2 months than the index biopsies and re-biopsies at 2-4 months (P   =   0.02). SV40-TAg positivity was common in re-biopsies during the first 2 months (10/11 biopsies), but rarer at 2-4 months (2/8 biopsies, P   =   0.001). CONCLUSIONS: @entity3 and increased @entity2 , called immune reconstitution, were observed at 2 months. Later sCr reversal is associated with remission.

title: Temporal serum @entity4 increase and exacerbation of @entity2 during the first two months in resolving XXXX @entity1 .

answer: @entity5


abstract: UNASSIGNED: Neuronal stress or injury results in the activation of proteins, which regulate the balance between survival and apoptosis. However, the complex mechanism of cell signaling involving cell death and survival, activated in response to cellular stress is not yet completely understood. To bring more clarity about these mechanisms, a Boolean network was constructed that represented the apoptotic pathway in neuronal cells. @entity7 and @entity2 factor (NGF) were considered as inputs in the absence and presence of @entity5 proteins known to shift the balance toward survival by rescuing pro-apoptotic cells. The probabilities of survival, DNA repair and apoptosis as cellular fates, in the presence of either the growth factor or @entity7 , revealed a survival bias encoded in the network. Boolean predictions tested by measuring the mRNA level of @entity0 , @entity6 , and @entity4 in neuronal Neuro2a (N2a) cell line with NGF and @entity7 as external input, showed positive correlation with the observed experimental results for survival and apoptotic states. It was observed that @entity1 contributed more toward rescuing cells from apoptosis in comparison to @entity8 , @entity12 , and @entity13 . Overexpression of @entity1 in N2a transfected cells showed reversal of cellular fate from @entity7 -induced apoptosis to survival. Further, the pro-survival role of the proteins @entity3 , @entity10 , cFLIP, and NFkB determined by vertex perturbation analysis was experimentally validated through protein inhibition experiments using EM20-25, @entity9 and @entity11 , which resulted in 1.27-, 1.26-, and 1.46-fold increase in apoptosis of N2a cells. The existence of a one-to-one correspondence between cellular fates and attractor states shows that Boolean networks may be employed with confidence in qualitative analytical studies of biological networks.

title: XXXX mediates survival in apoptotic cells-Boolean network prediction and experimental validation.

answer: @entity1


abstract: UNASSIGNED: @entity6 means that one's kidney have unexpectedly stopped functioning, i.e., once chronic disease is exposed, the presence or degree of @entity2 and its progression must be assessed, and the underlying syndrome has to be diagnosed. Although the @entity0 's history and physical examination may denote good practice, some key information has to be obtained from valuation of the glomerular filtration rate, and the analysis of serum biomarkers. Indeed, chronic kidney sickness depicts @entity2 and/or its makeup, i.e., there is evidence that treatment may avoid or delay its progression, either by reducing and prevent the development of some associated complications, namely @entity5 , @entity3 , @entity1 , and @entity4 . @entity8 appears abruptly, with a rapid deterioration of the renal function, but is often reversible if it is recognized early and treated promptly. In both situations, i.e., @entity8 and @entity7 , an early intervention can significantly improve the prognosis. The assessment of these pathologies is therefore mandatory, although it is hard to do it with traditional methodologies and existing tools for problem solving. Hence, in this work, we will focus on the development of a hybrid decision support system, in terms of its knowledge representation and reasoning procedures based on Logic Programming, that will allow one to consider incomplete, unknown, and even contradictory information, complemented with an approach to computing centered on Artificial Neural Networks, in order to weigh the Degree-of-Confidence that one has on such a happening. The present study involved 558 @entity0 with an age average of 51.7  years and the @entity7 was observed in 175 cases. The dataset comprise twenty four variables, grouped into five main categories. The proposed model showed a good performance in the diagnosis of @entity7 , since the sensitivity and the specificity exhibited values range between 93.1 and 94.9 and 91.9-94.2  %, respectively.

title: A Soft Computing Approach to XXXX Evaluation.

answer: @entity2


abstract: Second @entity1 (SPMs) are issues for @entity0 with @entity2 ( @entity2 ). There may have been some limitations in prior studies, such as difficulties in a longer follow-up and absence of established screening methods. Therefore, we studied autopsied cases to overcome these limitations. This study aimed to examine SPMs using autopsy reports. Ninety-one cases of @entity2 autopsied at our institution from 1979 to 2013 were analyzed. Median age of autopsied @entity0 was 64.1 years, and proportion of male/female was 59/32. Autopsy was performed in 35.3% of @entity0 died of @entity2 . There were five cases of SPMs with a median confirmation time of 38 (12-132) months from the diagnosis of @entity2 . In three of the five @entity0 , the diagnosis of SPMs was established at autopsy. One case was of @entity3 , and the others were of non-hematological @entity1 . The annual risk of @entity4 estimated using the Kaplan-Meier method was approximately 1%. Three of five @entity4 cases were detected at autopsy. Analysis of autopsy may contribute to estimate the actual risk of SPMs in @entity2 .

title: Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary XXXX .

answer: @entity1


abstract: Young, specific-pathogen-free @entity2 were fed purified diets containing different sources of fat. Food intake was depressed and @entity2 lost weight when the diet contained either hydrogenated coconut oil ( @entity0 ) or medium-chain @entity4 (MCT). With an MCT preparation enriched in 8:0 (MCT8), @entity2 would not eat after first tasting the diet. When @entity2 were offered a choice of two high-fat diets, they chose the basal diet over a diet containing 30% @entity0 , by a ratio of 4.5:1. Low levels of MCT8 (5% or 10% by weight) were also rejected, whereas @entity2 did not reject 5% or 15% MCT12. @entity5 , at 0.1-1.0% of the diet, was rejected. In other studies, food intake and body weight decreased when @entity0 was added to a fat-free diet. @entity2 fed 25% or 35% @entity0 lost weight. When 5% safflower seed oil was added to the @entity0 diets, body weights and food intake improved, but were still less than optimal. These studies indicate that the food intake @entity1 in @entity2 fed dietary @entity0 and MCT is primarily a result of impalatability, and that the @entity3 moiety may be responsible for the aversion.

title: Aversion of the cat to dietary medium-chain @entity4 and XXXX .

answer: @entity5


abstract: AIMS: To evaluate the long-term safety and efficacy of a simplified basal-bolus regimen of once-daily insulin degludec/insulin aspart (IDeg @entity3 ) with additional IAsp vs. a standard basal-bolus insulin regimen of insulin detemir (IDet) with IAsp in adults with Type  1 @entity1 . METHODS: This was an open-label trial compromising a 26-week core phase followed by a 26-week extension phase. @entity0 were randomized to IDegAsp once daily at the main meal and IAsp at remaining meals (IDegAsp+IAsp), or IDet (once or twice daily) and IAsp at all meals (IDet+IAsp). Insulins were titrated to target plasma @entity2 of <  5  mmol/l (<  90  mg/dl) at pre-breakfast (IDegAsp and IDet) and at pre-meal (IAsp). RESULTS: After 52  weeks, the overall confirmed hypoglycaemia rate was 31.8  episodes/ @entity0 -years of exposure (PYE) with IDegAsp+ @entity3 and 36.7  episodes/PYE with IDet+IAsp, and the rate of nocturnal confirmed hypoglycaemia was significantly lower with IDegAsp+ @entity3 than with IDet+IAsp (3.1 vs. 5.4  episodes/PYE, respectively; P  <  0.05). Adverse event rates were comparable between groups. Mean HbA1c decreased from baseline by 0.7% (IDegAsp+IAsp) and 0.6% (IDet+IAsp), achieving 60 or 61  mmol/mol (7.6% or 7.7%, respectively), at Week 52. The mean total daily insulin dose was lower with IDegAsp+IAsp than with IDet+IAsp (ratio: 0.87; 95% CI 0.79-0.95; P  =  0.0026). CONCLUSIONS: Once-daily treatment with IDegAsp and IAsp as bolus insulin for remaining meals was associated with significantly lower risk of nocturnal confirmed hypoglycaemia, improved glycaemic control and showed non-inferiority compared with IDet+IAsp, the standard of care in Type  1 @entity1 . This article is protected by copyright. All rights reserved.

title: Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal-bolus treatment in XXXX with Type  1 @entity1 : 1-year results from a randomized clinical trial (BOOST(  ) T1).

answer: @entity0


abstract: @entity7 are macroscopically visible morphological changes of the mucosa that can develop focal @entity2 in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the @entity7 sequence were primarily based on DNA studies of exophytic, polypoid-type @entity3 . Not all colorectal lesions, however, display an exophytic phenotype and a presumed distinct @entity1 , the nonpolypoid @entity3 , was subsequently described as a precursor of @entity1 . The low incidence of @entity5 mutations in nonpolypoid @entity7 reported previously suggested a different genetic basis for the transformation process in these lesions. We have pursued the identification of genetic changes in benign sporadic nonpolypoid @entity7 in a selected Swedish @entity0 group with no family history of @entity1 . Mutation screening of the @entity6 ( @entity6 ), @entity5 , and @entity4 genes was conducted using the protein truncation test, heteroduplex-single-strand conformation polymorphism analysis, and denaturing gradient gel electrophoresis on PCR-amplified fragments. Fourteen mutations in the @entity6 gene were characterized in 10/20 samples. Mutations in the @entity5 and @entity4 genes were identified in 3/57 and 4/51 @entity3 , respectively. The mutation frequencies and distribution of mutations in @entity6 correlate with published data on exophytic @entity3 . The low mutation frequency of the @entity4 gene is consistent with the benign nature of the research material. @entity5 activation (an early event in polypoid @entity7 ) apparently does not play a significant role in nonpolypoid @entity3 development but may result in the development of a polypoid configuration. Genes Chromosomes Cancer 27:202-208, 2000.

title: Somatic mutations of the @entity6 , XXXX , and @entity4 genes in nonpolypoid @entity7 .

answer: @entity5


abstract: UNASSIGNED: Acute suprarenal aortic occlusion is a rare but often catastrophic event. Despite immediate treatment, mortality and morbidity are high. We present a case of acute suprarenal aortic occlusion presenting with @entity2 and @entity5 but without @entity1 . Diagnosis was initially not taken in consideration. The @entity0 required hemodialysis and temporary mechanical ventilation. After 13  days, an abdominal ultrasound was performed which revealed @entity3 of the suprarenal abdominal aorta. Suprarenal aortic thrombectomy was performed followed by aortobi-iliac bypass grafting. Diuresis returned 4  hr after surgery, and the @entity0 fully recovered. Thorough review of the literature revealed only 8 cases of acute suprarenal aortic occlusion. Only 3 @entity0 survived. To our knowledge, this is the first reported case of acute suprarenal occlusion, in which renal function could be restored after a 14-day period of @entity6 . The case illustrates that in select cases with prolonged @entity4 aortorenal revascularization can be performed successfully.

title: Recovery of Renal Function after Prolonged XXXX in Acute Suprarenal Aortic Occlusion.

answer: @entity6


abstract: UNASSIGNED: Current options for aortic valve replacements are non-viable and thus lack the ability to grow and remodel, which can be problematic for paediatric applications. Toward the development of living valve substitutes that can grow and remodel, porcine aortic valve interstitial cells (VICs) were isolated and encapsulated within proteolytically degradable and cell-adhesive @entity1 ( @entity2 ) hydrogels, in an effort to study their phenotypes and functions. The results showed that encapsulated VICs maintained high viability and proliferated within the hydrogels. The VICs actively remodelled the hydrogels via secretion of @entity3 ( @entity3 ) and deposition of new extracellular matrix (ECM) components, including collagens I and III. The soft hydrogels with compressive moduli of ~4.3 kPa quickly reverted VICs from an activated myofibroblastic phenotype to a quiescent, unactivated phenotype, evidenced by the loss of a-smooth muscle actin expression upon encapsulation. In an effort to promote VIC-mediated ECM production, @entity0 (AA) was supplemented in the medium to investigate its effects on VIC function and phenotype. AA treatment enhanced VIC spreading and proliferation, and inhibited apoptosis. AA treatment also promoted VIC-mediated ECM remodelling by increasing @entity3 activity and depositing collagens I and III. AA treatment did not significantly influence the expression of a-smooth muscle actin (myofibroblast activation marker) and alkaline phosphatase (osteogenic differentiation marker). No calcification or nodule formation was observed within the cell-laden hydrogels, with or without AA treatment. These results suggest the potential of this system and the beneficial effect of AA in heart valve tissue engineering. Copyright    2015 John Wiley _ Sons, Ltd.

title: XXXX promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds.

answer: @entity0


abstract: BACKGROUND: @entity3 misuse, abuse, and @entity2 is becoming a new problem in medicine used in Thailand. OBJECTIVE: Study the prevalence of @entity3 use, misuse, abuse, and @entity2 in Ubon Ratchathani province Thailand. MATERIAL AND METHOD: A cross-sectional household survey was conducted between October 2008 and June 2009. The target population were the @entity0 age 15 and above. A sample size of 2280 was selected from three stage stratified random sampling. @entity3 were identified with generic name and drug characteristics. The DSM-IV questionnaires were used to define misuse, abuse, and @entity2 . @entity2 was interpreted with judgment of a @entity1 nurse. For statistical analyses, prevalence was estimated with weight adjustment, variances estimated by Teylor Series Linearization method, and interpreted with 95% CI. RESULTS: There were 46,805 current users [3.9% (95% CI: 2.2-6.4)], 26,404 misuser [2.2% (95% CI: 1.6-6.2)], 7203 abuser [0.6% (95% CI: 0.1-4.1)] and 2402 dependent [0.2% (95% CI: O. 1-9.2)]. When considering the group of current user, the results showed that 57.2% of this group misused, 16.6% abused and 5.9% were dependent. CONCLUSION: Prevalence of use was higher than previously reported in Thailand while more than half of the current users misused Surveillance ofmisuse should be done in the group of current user Medical professional should give recommendations to @entity0 , focusing on harm of misuse. Furthermore, they should limit the amount of medicine when it is necessary to dispense.

title: Prevalence of XXXX misuse in Ubon Ratchathani province Thailand.

answer: @entity3


abstract: @entity2 is a distal metaplasia characterized by the transformation of squamous mucosa into columnar mucosa. This esophageal phenotype is a product not only of the chronic reflux of gastric acids, but also by microorganisms that colonize the oral cavity and stomach. Two classes of microbiota can be identified in @entity2 ; microbiota type I is associated with the normal esophagus and type II with an inflamed esophagus. The present study describes the gastric microbiota of a @entity0 with antral @entity10 concomitant with @entity2 with @entity6 . Gastric biopsies were obtained following the protocol of Sydney and following ethical practices. The isolates were cultivated under microaerophilic conditions on Columbia Agar supplemented with IsoVitaleX    and 7% sterile blood. Extracted DNA was sequenced using 454-GS and the results analyzed on the MG-RAST server. Gram negative isolates were found and bacteria resistant to @entity3 , @entity1 , @entity4 , @entity8 , and @entity11 . The phyla Bacteroidetes, Firmicutes, Fusobacteria and Proteobacteria, the genus @entity7 and the species group @entity7 were most abundant. Functionally, the metabolism of @entity9 , @entity5 , and to a lesser extent, the metabolism of cofactors and vitamins were most dominant, and of which the enzymes    -glucosidase (EC 3.2.1.21),    -galactosidase (EC 3.2.1.23) and    -N-acetylhexosaminidase (EC 3.2.1.52) were most dominant. The findings of this study, because they are of only one case may probably suggest a possible pathogenic role, previously undescribed for @entity7 , associated with @entity0 @entity10 when concomitant esophageal pathology exists.

title: Metagenomic analysis of the gastric microbiota cultivable from a XXXX with @entity10 concomitant with @entity2 .

answer: @entity0


abstract: OBJECTIVE: To investigate the feasibility of our self made inferior vena cave (IVC) stent. METHODS: Self-expanding, stainless steel, Z-shaped stents were deployed in the IVC of 14 @entity0 . They were randomly divided into four groups, four @entity0 in the first three groups, and 2 in the fourth group. IVC specimens were taken at 2, 4, 8 and 16 weeks following stent deployment. No anticoagulant or antiplatelet therapy was given. RESULTS: All stents were widely stretched out and so was the vessel lumen. No @entity1 was present and the patency was 100% in all groups. The stents were completely covered by @entity2 2 weeks after stent deployment. The neointimal thickness varied significantly: the thinnest at 2 weeks, the thickest at 4 weeks and becoming thinner at 8 weeks and stable until 16 weeks. The inflammatory reaction was gradually reduced. Under scanning electronic microscopy, the @entity2 was covered by a layer of endothelial cells 2 weeks following stenting, which were irregularly shaped and aligned. The cells became slender, spindle-shaped and aligned parallel to the direction of bolld flow 4 weeks afterwards. CONCLUSION: Experimental study indicated that our self-expanding IVC stent was feasible for clinical application.

title: An experimental study of inferior vena caval stent in XXXX .

answer: @entity0


abstract: INTRODUCTION: @entity16 inhibitors (CIs) cause substantial long-term morbidity and mortality among orthotopic liver transplantation (OLT) @entity0 . Our aim was to evaluate the effectiveness and safety of @entity8 ( @entity14 ) among OLT @entity0 with CI-related side effects. @entity0 : Thirty three adult @entity0 , including 29 @entity0 and 4 @entity0 of mean age 57 years, underwent OLT between 1986 and 2000 under treatment with CIs (28 @entity3 and five @entity12 ). Mean follow-up after OLT was 59 months. Adverse effects were @entity1 in 26, @entity2 in 23, and @entity15 in two. @entity14 was added gradually while simultaneously reducing the dosage of CI. RESULTS: After a mean 15-months follow-up of @entity14 treatment, CIs had been withdrawn in 28 @entity0 (85%). The mean time from the initiation of @entity14 and CI withdrawal was 5 months. During the first year of follow-up chronic @entity1 improved in 16 of 26 @entity0 (61.6%) accompanied by a decreased serum @entity10 and @entity11 and an increase in @entity10 clearance. Among 13/23 (56.5%) @entity2 @entity0 , there was a significant @entity7 or the number of antihypertensive drugs (P<.05). One @entity0 with @entity15 improved. Twenty-two @entity0 (66%) displayed adverse events: five rejections (15%) including four acute episodes, controlled by CI re-introduction, and one chronic reaction. The most frequent adverse effects were @entity4 in 10 @entity0 (30%), @entity13 in nine (27%), @entity5 in five (15%) and @entity9 in four (12%). Nevertheless, only six @entity0 (19%) required @entity14 dose reduction, namely, three @entity0 with GI intolerance, two with repeated @entity4 , and one with @entity6 . CONCLUSIONS: @entity14 monotherapy improves renal function and blood pressure levels in more than 50% of @entity0 with chronic @entity1 and @entity2 after OLT. Many of the side effects of @entity14 were mild; it was safe accompanied by a low incidence of rejection reactions.

title: Effectiveness and safety of XXXX as monotherapy in liver transplantation.

answer: @entity8


abstract: UNASSIGNED: 1538 Background: @entity7 mellitus, a state of @entity4 intolerance associated with pregnancy is increasing in prevalence. Data regarding the risk associated with @entity7 is sparse and conflicting. The current study was conducted to examine the risk of incident over-all and site-specific @entity1 associated with a history of @entity2 in a historical cohort study of @entity0 in Maccabi Healthcare Services, a large health maintenance organization in Israel. METHODS: All @entity0 aged 15 to 50 years who underwent 50g @entity4 challenge tests between March 13, 1995 and May 27, 2009, without history of @entity1 , @entity2 or @entity3 were included. Clinical and demographic parameters at index date including age, socioeconomic level, BMI and parity were collected. @entity7 was based on the 100g oral @entity4 tolerance test using the standard Carpenter _ Coustan criteria. The main endpoint of the study was a diagnosis of @entity1 obtained from the Israel Cancer Register through linkage data. RESULTS: Among the 185,315 @entity0 who had undergone @entity4 challenge during the study period, 11,264 (6.1%) were diagnosed with gestational @entity2 . During a total follow-up period of 1.05 million @entity0 years, 2034 incident cases of @entity1 were identified. GDM was associated with a hazard ratio (HR) of 7.12 (95% CI: 1.71-29.67) for @entity5 and a HR of 1.69 (95% CI: 0.96-2.97) for @entity6 . The association between GDM and @entity6 was limited to @entity0 with five or more years of follow-up (HR=4.43; 1.79-10.96). CONCLUSIONS: @entity7 mellitus is strongly associated with an increased long-term risk of @entity5 and probably with @entity6 .

title: XXXX and risk of incident primary @entity1 : A large population-based cohort study in Israel.

answer: @entity7


abstract: PURPOSE: This study aimed to explore the value of IHC4 in predicting pathological response after neoadjuvant chemotherapy in @entity1 with @entity0 (BC). MATERIALS AND METHODS: In this retrospective exploratory study, data for 68 HR-positive BC @entity1 who received neoadjuvant chemotherapy were recorded. IHC4 scores were calculated based on @entity2 receptors/ @entity3 receptors, Ki-67 and @entity4 status. Logistic and ordinal regression analyses in addition to likelihood ratio test were used to explore associations of IHC4 scores and other clinico-pathological parameters with pathological complete response (pCR) and pathological stage. RESULTS: Taking the 25th percentile as the cut-off, a lower IHC4 score was associated with an increased probability of pCR (low; 52.9% vs. High; 21.6%, OR=4.1, 95% CI= 1.28-13.16, p=0.018) and a lower pathological stage (OR =3.9, 95% CI=1.34-11.33, p=0.012). When the IHC4 score was treated as a continuous variable, a lower score was again associated with an increased probability of pCR (OR=1.010, 95% CI=1.001-1.018, p=0.025) and lower pathological stage (OR=1.009, 95% CI= 1.002-1.017, P=0.008). Lower clinical stage was associated with a better pCR rate that was of borderline significance (P=0.056). When clinical stage and IHC4 score were incorporated together in a logistic model, the likelihood ratio test gave a P-value of 0.004 after removal of the IHC4 score and 0.011 after removal of the stage, indicating a more significant predictive value of the IHC4 score for pCR. CONCLUSIONS: This study suggests that the IHC4 score can predict pathological response to neoadjuvant chemotherapy in HR-positive BC @entity1 . This finding now needs to be validated in a larger cohort of @entity1 .

title: Predictive Value of IHC4 Score for Pathological Response to Neoadjuvant Chemotherapy in Hormone Receptor-Positive XXXX .

answer: @entity0


abstract: AIM OF THE STUDY: Internal @entity2 is an uncommon cause of @entity3 . The aim of this study was to retrospectively evaluate the diagnosis, the management, and the follow-up of the internal hernias operated over a 10-year period in our department of visceral surgery. METHODS: 14 spontaneous internal hernias were observed. The @entity0 were evaluated with respect to symptoms, radiological findings, time elapsed between the onset of symptoms and surgery, type of operation performed, postoperative morbidity and mortality, postoperative stay, and follow-up. RESULTS: There were 8 @entity0 and 6 @entity0 . The preoperative diagnosis was evoked in only one case. The mean time elapsed between the onset of the symptoms and surgery was 31.1 hours (range 6 to 72 hours). Two intestinal resection were performed. Mean postoperative hospital stay was 11.3 days (range 6 to 22 days). The morbidity was 21.4% with no mortality. Mean follow-up was 7 months (range 3 to 15 months); one @entity0 developed an incisional @entity2 . CONCLUSION: Since preoperative diagnosis of an internal @entity2 is difficult because of the lack of specific signs, morbidity and mortality can be decreased with early surgical intervention. Operative risks include @entity1 , especially to @entity2 neck vessels.

title: [Internal @entity2 : a rare cause of XXXX . Apropos of 14 cases].

answer: @entity3


abstract: PURPOSE: We determine the clinical characteristics, visual and anatomical outcomes, and factors associated with poor visual outcome and anatomical success in pediatric @entity2 ( @entity2 ). METHODS: The records of @entity0 aged 17  years and younger who had undergone surgical intervention after @entity2 between January 2000 and June 2010 were reviewed retrospectively. RESULTS: In total, 182 @entity0 were enrolled in the study (70.9  % males, 29.1  % females; mean age: 8.6        4.5  years [range 1-17  years]). @entity1 occurred mostly at home (45.1  %). Objects most often causing the @entity5 were sharp objects (74.1  %). Over one-third of the eyes (39.7  %) had final visual acuities of 20/200 or better. Anatomical success was achieved in 76.9  % of eyes. Time between primary globe repair and secondary surgical intervention was 61.4        144  days. Visual outcomes were poor in eyes with initial visual acuity less than for counting fingers, @entity3 , proliferative @entity4 , and @entity6 . Anatomical success rates were low with @entity3 . CONCLUSION: Visual outcomes seem to be poor in more than half of the @entity0 despite advanced microsurgical techniques.

title: XXXX : clinical characteristics and factors associated with poor visual and anatomical success.

answer: @entity2


abstract: BACKGROUND: Evaluation of the long-term impact of @entity7 on surviving @entity0 and their families is critical to fully comprehending the burden of @entity2 and to facilitating an evidence-based decision for the introduction of pneumococcal vaccine. This study was an investigation of the short- and long-term impacts of @entity7 among Bangladeshi @entity0 . METHODS: Case @entity0 with @entity7 who were hospitalized between January 2006 and March 2007 were subjected to short-term follow-up within 30-40 days of discharge. Case @entity0 discharged prior to January 2005 were selected for long-term follow-up at 6-24 months after the date of discharge. Both cohorts were enrolled from Dhaka Shishu Hospital, a pediatric hospital in Bangladesh. Healthy @entity0 matched for age, sex, socioeconomic status, and area of residence were recruited from the community as control subjects. During follow-up visits, case @entity0 and control subjects were assessed for their physical and neurodevelopmental status by use of a standardized protocol. The impact of @entity7 on siblings and the family as a whole was assessed by means of qualitative interviews. RESULTS: Neurodevelopmental assessments of the short-term follow-up cohort (n=51) revealed @entity6 in 33%, 8%, 41%, and 49% of the case @entity0 , respectively. These deficits were 18%, 4%, 41%, and 35% in the long-term follow-up cohort (n=51), respectively. @entity1 were seen in only 2% of the control subjects, none of whom had vision or @entity4 . CONCLUSIONS: In addition to the risk of @entity3 , @entity7 in @entity0 causes severe disabilities among survivors, as well as disruption of the life of other siblings and family members. This study demonstrated that high rates of sequelae are associated with @entity7 . Neurodevelopmental assessment during follow-up of @entity0 with @entity5 is critical to our understanding of the burden of the adverse consequences of @entity2 . These data, along with the fact of poor access to health care, provide a compelling argument in favor of the introduction of pneumococcal vaccine, specifically in a setting where access to health care is poor and disabled @entity0 remain incapacitated because of a lack of resources and facilities.

title: Neurodevelopmental sequelae in XXXX cases in Bangladesh: a comprehensive follow-up study.

answer: @entity7


abstract: UNASSIGNED: The @entity7 B2 receptor ( @entity8 ) plays a key role in the @entity2 process of @entity4 . @entity6 has also long been considered to be a catabolic factor that contributes to inflammatory response and the @entity3 pathology. Several studies have reported that the @entity8 +9/-9   bp polymorphisms are associated with transcription of the receptor. However, the roles of @entity8 polymorphisms in @entity2 in @entity4 remain unclear. This study enrolled 156 subjects with primary @entity5 and 58 healthy volunteers. @entity8 polymorphisms were genotyped, and the mRNA and protein levels of @entity8 in synovial tissues from @entity4 @entity0 were measured by quantitative real-time polymerase chain reaction and western blot analysis, respectively. @entity6 production in serum from @entity0 with @entity4 was measured using a @entity6 assay kit. We found that the mean @entity8 mRNA levels were significantly higher in Kallgren-Lawrence grade-4 @entity4 @entity0 than @entity0 with lower grade @entity4 . The +9/-9   bp polymorphisms significantly affected the @entity8 mRNA and protein expression levels in synovial tissues from @entity4 subjects. @entity4 @entity0 with +9/-9 and -9/-9 genotypes had higher @entity8 expression levels in synovial tissue and @entity6 production in serum. Moreover, positive correlation was found between the @entity8 levels in synovial tissue and @entity6 production. Compared with health controls, significant increases of @entity6 production in @entity4 were detected which were associated with increasing severity of @entity4 . Multiple linear regression analysis (adjusted for gender and age) showed serum @entity6 level was positively associated with @entity8 polymorphism and Kallgren-Lawrence grade and was inversely associated with @entity1 . Our findings showed that the @entity8 +9/-9   bp polymorphisms affected the gene expression and @entity6 production, which were associated with radiographic severity of @entity4 , suggesting that the @entity8 +9/-9   bp polymorphisms may act as a genetic modulator of @entity4 , and play an essential role in inflammatory process in @entity4 .

title: @entity8 +9/-9   bp polymorphisms influence @entity8 expression levels and NO production in XXXX .

answer: @entity5


abstract: OBJECTIVE: Frail, elderly and immobile @entity0 frequently have difficulty in tolerating formal colonic investigations. @entity1 may account for up to 35% of @entity1 . Barium enema and colonoscopy have limitations in assessing this region. The aims of this study were to evaluate the accuracy of a minimal preparation CT technique (merely with prolonged oral contrast medium) in identifying @entity2 and to determine helpful radiological signs. MATERIALS AND METHODS: The CT technique involved helical acquisition following 2 days of preparation with oral contrast medium. The outcome of 4 years' experience (1995-1998) was reviewed. The gold-standards were pathological and @entity1 registration records, together with colonoscopy and barium enema where available, with a minimum of 15 months' follow-up. RESULTS: CT correctly identified 27 of 30 @entity2 , and missed three, in a total of 1077 CT studies in 1031 @entity0 (median age 80 years). There were also 21 false-positive cases in which CT incorrectly raised the possibility of a caecal @entity1 . The sensitivity, specificity, negative predictive value (NPV) and positive predictive value ( @entity3 ) were 90%, 98%, 99% and 56%, respectively. Serosal margin blurring, @entity1 length, presence of abnormal peri-colic fat and terminal ileal wall thickening were identified as useful radiological signs. CONCLUSIONS: Minimal preparation CT is able to identify @entity2 with fair accuracy. Such evaluation may become important given the increasing population age and evidence of a 'proximal shift' in the site of @entity1 in the elderly.

title: XXXX in the elderly: useful signs in minimal preparation CT.

answer: @entity2


abstract: UNASSIGNED: Herein, we present a simple and green method for the synthesis of gold nanoparticles (AuNPs) using the phytoproteins of @entity2 leaves. Under ambient sunlight irradiation, the isolated phytoprotein complex from @entity2 leaves reduces the gold @entity3 aqueous solution and stabilizes the formed AuNPs. As prepared nanoparticles were characterized by UV-visible spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, zeta potential, transmission electron microscopy (TEM) and @entity4 ( @entity4 ). The surface plasmon resonance (SPR) maximum for AuNPs was observed at 520nm. The zeta potential value estimated for the AuNPs is -27.0mV, indicating that the NPs are well separated. Transmission electron micrographs revealed that the particles are spherical in nature with the size range from 10 to 15nm. AuNPs act as a catalyst in the degradation of an @entity5 dye, @entity6 in an aqueous environment. The reduction rate was determined to be pseudo-first order. Electrocatalytic efficiency of the synthesized AuNPs via this green approach was studied by chronoamperometry using @entity1 and @entity0 as a model compound for oxidation and reduction, respectively. Electrocatalytic studies indicate that the gold nanoparticles can be used to detect @entity1 and @entity0 in micromolar concentrations with response time less than 3s.

title: Phytoproteins in green leaves as building blocks for photosynthesis of gold nanoparticles: An efficient electrocatalyst towards the oxidation of XXXX and the reduction of @entity0 .

answer: @entity1


abstract: OBJECTIVE: @entity0 ( @entity0 ) caused by @entity4 remains a worldwide burden. @entity8 is a promising new therapeutic avenue for the treatment of @entity0 , however reports show exogenous @entity9 has both vasodilator and vasoconstrictor effects depending on organ examined, and in vitro studies in animal models which are not resistant to developing @entity4 are limited. We sought to determine if @entity1 arteries constricted or dilated to @entity8 . MATERIAL AND METHODS: The aorta, carotid, renal and iliac arteries were harvested from New Zealand White @entity1 (n=4) and subjected to a concentration response curve to the fast @entity9 releaser @entity10 . In addition, a bolus dose of @entity10 was used to determine if further dilation was achievable after maximum dilation to @entity6 similar to @entity5 donors. Further, @entity10 was used to determine if @entity9 could impair @entity7 induced @entity2 . RESULTS: Blood vessels relaxed poorly to @entity10 and contracted at higher doses. A bolus dose of @entity10 relaxed then contracted the aorta, however a bolus dose of @entity10 after maximal relaxation to @entity6 caused marked contraction. @entity10 did not prevent @entity7 induced @entity3 . CONCLUSION: @entity10 at low doses caused minor relaxation of @entity1 blood vessels, indicating a possible therapeutic benefit for low dose @entity9 in the cellular milieu.

title: XXXX causes contraction and relaxation of major arteries of the @entity1 .

answer: @entity9


abstract: INTRODUCTION: @entity3 ( @entity3 ) is characterized by the deposition of tau and amyloid in the brain. Although the core cerebrospinal fluid (CSF) @entity3 biomarkers amyloid b peptide 1-42 (Ab1-42), total tau (t-tau) and phosphorylated tau 181 (p-tau181) show good diagnostic sensitivity and specificity, additional biomarkers that can aid in preclinical diagnosis or better track disease progression are needed. Activation of the complement system, a pivotal part of @entity1 , occurs at very early stages in the @entity3 brain. Therefore, CSF levels of complement proteins that could be linked to cognitive and structural changes in @entity3 may have diagnostic and prognostic value. METHODS: Using xMAP   technology based assays we measured complement 3 ( @entity7 ) and @entity6 ( @entity6 ) in the CSF of 110 controls (CN), 187 @entity2 ( @entity2 ) and 92  @entity3 subjects of the @entity3 Neuroimaging Initiative (ADNI) at baseline. All ADNI @entity0 underwent clinical follow-up at 12  month intervals and @entity2 subjects had additional visits at 6 and 18  months. The association between CSF biomarkers and different outcome measures were analyzed using Cox proportional hazard models (conversion from @entity2 to @entity3 ), logistic regression models (classification of clinical groups) and mixed-effects models adjusted for age, gender, education, t-tau/Ab1-42 and @entity5 presence (baseline and longitudinal association between biomarkers and cognitive scores). RESULTS: Although no association was found between the complement proteins and clinical diagnosis or cognitive measures, lower levels of @entity7 (b   =   -0.12, p   =   0.041) and @entity6 (b   =   -0.075, p   =   0.041) were associated with faster @entity2 in @entity2 subjects as measured by the @entity3 Assessment Scale-cognitive subscale (ADAS-Cog) test. Furthermore, lower @entity6 levels were associated with larger lateral ventricular volume (p   =   0.024), which is indicative of @entity4 . CONCLUSIONS: Our study confirms a lack of suitability of CSF C3 and @entity6 as diagnostic biomarkers of @entity3 , but points to their modest potential as prognostic biomarkers and therapeutic targets in @entity2 @entity0 .

title: Low levels of cerebrospinal fluid complement 3 and XXXX predict faster @entity2 in @entity2 .

answer: @entity6


abstract: The purpose of the present study was to investigate the prognostic significance of DNA ploidy, S-phase fraction and @entity6 oncoprotein expression in @entity0 with @entity2 and to correlate these factors with the clinical behavior of the @entity1 and their response to therapy. Of 79 @entity0 with @entity2 57% (45/79) had early stage disease. Forty-one percent (32/79) had @entity1 while 30% (24/79) of the @entity1 had a high (>10%) S-phase fraction. @entity6 oncoprotein expression was detected in 38% (30/79) of @entity1 . @entity0 with @entity1 had a worse prognosis than @entity0 with @entity1 (p=0.0002). Similarly, @entity0 with high S-phase fraction @entity1 had a shorter survival than those with low S-phase fraction @entity1 (p=0.005). No such difference was found between @entity5 raspositive and @entity5 ras-negative @entity1 subgroups. In early stage @entity2 , @entity4 was closely correlated with disease outcome (p=0.029). Early stage @entity0 with @entity1 who received radiotherapy and chemotherapy had a better prognosis than @entity0 with @entity1 . In conclusion, DNA ploidy is a significant and independent prognostic factor in @entity2 . @entity3 of the @entity6 oncoprotein are important in determining the biological aggressiveness of @entity2 . Furthermore, DNA ploidy may identify those subgroups of @entity0 with early stage disease who may benefit from more aggressive treatment.

title: Prognostic significance of DNA @entity4 and XXXX oncoprotein expression in @entity2 and their role in the determination of treatment modalities.

answer: @entity6


abstract: BACKGROUND: In @entity2 , mast cells, activated by cross-linking of allergen to mast cell-bound specific IgE, release both vasoactive mediators related to the early nasal symptoms and chemotactic mediators that attract inflammatory cells, such as eosinophils, related to the late-phase response. OBJECTIVE: We have analyzed, during and out of pollen season, in blood and nasal fluid from @entity0 allergic to grass pollen, @entity1 and tryptase to monitor the early phase markers and eosinophil and @entity3 ( @entity3 ) to monitor the late phase. METHODS: Twenty @entity0 were enrolled in the study. As a control, we studied 10 nonatopic subjects. Mediators and eosinophils were assessed in blood and nasal fluid. @entity1 was tested only in nasal fluid. RESULTS: During pollen season, tryptase but not @entity1 increased in nasal fluids from @entity0 (2.96 vs 0.22 U/ml, p = 0.001) and correlated with symptom scores (r(s) = 0.63, p = 0.003). Tryptase was not detected in serum. Eosinophils increased in nasal cytology (17.0% vs 2.0%, p = 0.001) and in the blood (265 vs 12.7 x 10(6) L, p = 0.001) from @entity0 , but they did not correlate with symptom scores. @entity3 increased only in the nasal lavage (1633 vs 1.30 ng/ml, p = 0.001) and correlated with symptom scores (r(s) = 0.53, p = 0.016). CONCLUSIONS: Both @entity3 and tryptase increase in nasal secretion in natural disease. Therefore the measurement of tryptase and @entity3 levels in nasal fluid might be a useful clinical test for monitoring disease activity and the effects of therapeutic agents.

title: XXXX to grass pollen: measurement of inflammatory mediators of mast cell and eosinophils in native nasal fluid lavage and in serum out of and during pollen season.

answer: @entity2


abstract: BACKGROUND: To compare the correlation of TANIS and 1997 UICC stage grouping with survival rate in @entity1 . METHODS: A series of 820 @entity0 affected by @entity2 of paranasal sinuses (43 @entity0 ), oral cavity (100 @entity0 ), oropharynx (64 @entity0 ), larynx (599 @entity0 ) and parotid gland (134 @entity0 ) was considered in this retrospective study for a minimum follow-up of 5 years. The data set was classified according to 1997 UICC T-category and then grouped as recommended by the two systems. Data were analyzed by means of survival analyses (Kaplan-Meier and Cox algorithms). RESULTS: The total disease-specific survival rate at 5 years was 44% for paranasal sinuses, 54% for oral cavity, 28% for oropharynx, 86% for larynx and 65% for parotid gland. Globally, univariate analysis by means of Log Rank Test yielded significant p-values both for TANIS and 1997 UICC systems. Multivariate analysis (Cox regression adjusted for age and gender) showed a significant correlation between the two staging systems with the mortality rate. However, TANIS resulted in a higher prognostic value in oral cavity, oropharynx and larynx that are three sites affected by a homogeneous histological type of @entity2 (i.e. @entity3 ). CONCLUSIONS: TANIS stage grouping better defines the prognosis for @entity1 than the 1997 UICC system.

title: [Stage grouping for XXXX : a meta-analysis].

answer: @entity1